Beta-hexosaminidase
|
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30033380 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 17Note: Hover over icons to view figure legend
Homology
BLAST of Beta-hexosaminidase vs. Ensembl Human
Match: HEXB (hexosaminidase subunit beta [Source:HGNC Symbol;Acc:HGNC:4879]) HSP 1 Score: 471.085 bits (1211), Expect = 2.613e-160 Identity = 232/506 (45.85%), Postives = 329/506 (65.02%), Query Frame = 1
Query: 133 PKPFYIYSGGNVFNLV-ENIKIQN-----PYPQCNLLNDAIKRFTKYLYNSIYINYEGPINQSISKISISMVTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGEDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDG---KKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETMNGGGTYCN 1623
P P + N+ +L EN I + P C LL +A +R+ Y++ ++E Q+ +++ ++ + T +P + ESY + V + + + VWG LR L+T Q+ Y+ S G INE+ + D RF RG+++DTSRH+LPV+ IL ++ M+ +K NV HWHIVDD+SFPYQS TFP+LS+KGS+ SHVYT DV ++++AR RGIRV+PEFD+PGH+LSWGKGQK+LLTPCYS SFGPI+PTL+ TY+FL FKE+ E+FPD +HLGGDEV F CW+SNP+I +F + GF DF KL+ +Y+ K+ +++ + + ++VWQEVFD+K ++ TI+ VWK + + +E++ VT S + +LS+ WYL+ ISYG DW KYY +P +F G +K L IGGEAC+WGEYVDATN+ R WPRAS V ERLWS++ V D++D +RL RCR+V G A+ + G YCN
Sbjct: 58 PLPLLVKMTPNLLHLAPENFYISHSPNSTAGPSCTLLEEAFRRYHGYIFGFYKWHHEPAEFQAKTQVQ-QLLVSITLQSECDAFPNISSDESYTLLVKEPVAVLKANRVWGALRGLETFSQLVYQDSYGTFTINESTIIDSPRFSHRGILIDTSRHYLPVKIILKTLDAMAFNKFNVLHWHIVDDQSFPYQSITFPELSNKGSY-SLSHVYTPNDVRMVIEYARLRGIRVLPEFDTPGHTLSWGKGQKDLLTPCYSRQNKLDSFGPINPTLNTTYSFLTTFFKEISEVFPDQFIHLGGDEVEFKCWESNPKIQDFMRQKGFGTDFKKLESFYIQKVLDIIATI-----NKGSIVWQEVFDDKAKLAPG-TIVEVWK-DSAYPEELSRVTASGFPVILSAPWYLDLISYGQDWRKYYKVEPLDFGGTQKQKQLFIGGEACLWGEYVDATNLTPRLWPRASAVGERLWSSKDVRDMDDAYDRLTRHRCRMVERGIAAQPLYAG--YCN 552
BLAST of Beta-hexosaminidase vs. Ensembl Human
Match: HEXA (hexosaminidase subunit alpha [Source:HGNC Symbol;Acc:HGNC:4878]) HSP 1 Score: 456.062 bits (1172), Expect = 9.095e-155 Identity = 228/477 (47.80%), Postives = 319/477 (66.88%), Query Frame = 1
Query: 208 PQCNLLNDAIKRFTKYLYNSIY--INYEGPINQSISK--ISISMVTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGED---KWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDG---KKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETMNGG 1608
P C++L++A +R+ L+ S Y ++ K + +S+VT + PT +E+Y + + D ++S+ VWG LR L+T Q+ ++ + G IN+T + D RF RGL+LDTSRH+LP+ +ILD +++M+ +KLNVFHWH+VDD SFPY+S TFP+L KGS++ +H+YT +DV ++++AR RGIRV+ EFD+PGH+LSWG G LLTPCYSGS+PSG+FGP++P+L+ TY F++ F EV +FPD LHLGGDEV+F CWKSNP I +F K GF DF +L+ +Y+ L ++V K + +VWQEVFDNK ++ Q TII VW+ ED + +E+ VTK+ + A+LS+ WYLN ISYG DW +Y +P F+G +K LVIGGEACMWGEYVD TN++ R WPRA VAERLWSN+ +DL RL FRC L+ G A+ +N G
Sbjct: 56 PGCSVLDEAFQRYRDLLFGSGSWPRPYLTGKRHTLEKNVLVVSVVTPGCNQ-----LPTLESVENYTLTINDDQCLLLSETVWGALRGLETFSQLVWKSAEGTFFINKTEIEDFPRFPHRGLLLDTSRHYLPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYNPVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSEPSGTFGPVNPSLNNTYEFMSTFFLEVSSVFPDFYLHLGGDEVDFTCWKSNPEIQDFMRKKGFGEDFKQLESFYIQTLLDIVSSYG---KGY--VVWQEVFDNKVKI-QPDTIIQVWR-EDIPVNYMKELELVTKAGFRALLSAPWYLNRISYGPDWKDFYIVEPLAFEGTPEQKALVIGGEACMWGEYVDNTNLVPRLWPRAGAVAERLWSNKLTSDLTFAYERLSHFRCELLRRGVQAQPLNVG 520
BLAST of Beta-hexosaminidase vs. Ensembl Human
Match: HEXA (hexosaminidase subunit alpha [Source:HGNC Symbol;Acc:HGNC:4878]) HSP 1 Score: 454.907 bits (1169), Expect = 3.347e-154 Identity = 225/490 (45.92%), Postives = 320/490 (65.31%), Query Frame = 1
Query: 208 PQCNLLNDAIKRFTKYLYNS-----------------IYINYEGPINQSISKISISMVTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGED---KWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDG---KKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETMNGG 1608
P C++L++A +R+ L+ S +++ + +++ +S+ + C PT +E+Y + + D ++S+ VWG LR L+T Q+ ++ + G IN+T + D RF RGL+LDTSRH+LP+ +ILD +++M+ +KLNVFHWH+VDD SFPY+S TFP+L KGS++ +H+YT +DV ++++AR RGIRV+ EFD+PGH+LSWG G LLTPCYSGS+PSG+FGP++P+L+ TY F++ F EV +FPD LHLGGDEV+F CWKSNP I +F K GF DF +L+ +Y+ L ++V K + +VWQEVFDNK ++ Q TII VW+ ED + +E+ VTK+ + A+LS+ WYLN ISYG DW +Y +P F+G +K LVIGGEACMWGEYVD TN++ R WPRA VAERLWSN+ +DL RL FRC L+ G A+ +N G
Sbjct: 56 PGCSVLDEAFQRYRDLLFGSGSWPRPYLTGWPHQAYPVFLGKRHTLEKNVLVVSV-VTPGCNQ------LPTLESVENYTLTINDDQCLLLSETVWGALRGLETFSQLVWKSAEGTFFINKTEIEDFPRFPHRGLLLDTSRHYLPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYNPVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSEPSGTFGPVNPSLNNTYEFMSTFFLEVSSVFPDFYLHLGGDEVDFTCWKSNPEIQDFMRKKGFGEDFKQLESFYIQTLLDIVSSYG---KGY--VVWQEVFDNKVKI-QPDTIIQVWR-EDIPVNYMKELELVTKAGFRALLSAPWYLNRISYGPDWKDFYIVEPLAFEGTPEQKALVIGGEACMWGEYVDNTNLVPRLWPRAGAVAERLWSNKLTSDLTFAYERLSHFRCELLRRGVQAQPLNVG 531
BLAST of Beta-hexosaminidase vs. Ensembl Human
Match: HEXA (hexosaminidase subunit alpha [Source:HGNC Symbol;Acc:HGNC:4878]) HSP 1 Score: 448.358 bits (1152), Expect = 4.466e-152 Identity = 224/465 (48.17%), Postives = 313/465 (67.31%), Query Frame = 1
Query: 208 PQCNLLNDAIKRFTKYLYNSIYIN--YEGPINQSISK--ISISMVTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGED---KWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDG---KKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLV 1572
P C++L++A +R+ L+ S Y ++ K + +S+VT + PT +E+Y + + D ++S+ VWG LR L+T Q+ ++ + G IN+T + D RF RGL+LDTSRH+LP+ +ILD +++M+ +KLNVFHWH+VDD SFPY+S TFP+L KGS++ +H+YT +DV ++++AR RGIRV+ EFD+PGH+LSWG G LLTPCYSGS+PSG+FGP++P+L+ TY F++ F EV +FPD LHLGGDEV+F CWKSNP I +F K GF DF +L+ +Y+ L ++V K + +VWQEVFDNK ++ Q TII VW+ ED + +E+ VTK+ + A+LS+ WYLN ISYG DW +Y +P F+G +K LVIGGEACMWGEYVD TN++ R WPRA VAERLWSN+ +DL RL FRC L+
Sbjct: 56 PGCSVLDEAFQRYRDLLFGSGSWPRPYLTGKRHTLEKNVLVVSVVTPGCNQ-----LPTLESVENYTLTINDDQCLLLSETVWGALRGLETFSQLVWKSAEGTFFINKTEIEDFPRFPHRGLLLDTSRHYLPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYNPVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSEPSGTFGPVNPSLNNTYEFMSTFFLEVSSVFPDFYLHLGGDEVDFTCWKSNPEIQDFMRKKGFGEDFKQLESFYIQTLLDIVSSYG---KGY--VVWQEVFDNKVKI-QPDTIIQVWR-EDIPVNYMKELELVTKAGFRALLSAPWYLNRISYGPDWKDFYIVEPLAFEGTPEQKALVIGGEACMWGEYVDNTNLVPRLWPRAGAVAERLWSNKLTSDLTFAYERLSHFRCELL 508
BLAST of Beta-hexosaminidase vs. Ensembl Human
Match: HEXB (hexosaminidase subunit beta [Source:HGNC Symbol;Acc:HGNC:4879]) HSP 1 Score: 382.489 bits (981), Expect = 7.192e-129 Identity = 181/337 (53.71%), Postives = 242/337 (71.81%), Query Frame = 1
Query: 622 MSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGEDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDG---KKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETMNGGGTYCN 1623
M+ +K NV HWHIVDD+SFPYQS TFP+LS+KGS+ SHVYT DV ++++AR RGIRV+PEFD+PGH+LSWGKGQK+LLTPCYS SFGPI+PTL+ TY+FL FKE+ E+FPD +HLGGDEV F CW+SNP+I +F + GF DF KL+ +Y+ K+ +++ + + ++VWQEVFD+K ++ TI+ VWK + + +E++ VT S + +LS+ WYL+ ISYG DW KYY +P +F G +K L IGGEAC+WGEYVDATN+ R WPRAS V ERLWS++ V D++D +RL RCR+V G A+ + G YCN
Sbjct: 1 MAFNKFNVLHWHIVDDQSFPYQSITFPELSNKGSYS-LSHVYTPNDVRMVIEYARLRGIRVLPEFDTPGHTLSWGKGQKDLLTPCYSRQNKLDSFGPINPTLNTTYSFLTTFFKEISEVFPDQFIHLGGDEVEFKCWESNPKIQDFMRQKGFGTDFKKLESFYIQKVLDIIATI-----NKGSIVWQEVFDDKAKLAPG-TIVEVWK-DSAYPEELSRVTASGFPVILSAPWYLDLISYGQDWRKYYKVEPLDFGGTQKQKQLFIGGEACLWGEYVDATNLTPRLWPRASAVGERLWSSKDVRDMDDAYDRLTRHRCRMVERGIAAQPLYAG--YCN 327
BLAST of Beta-hexosaminidase vs. Ensembl Celegans
Match: hex-1 (Beta-hexosaminidase A [Source:UniProtKB/Swiss-Prot;Acc:Q22492]) HSP 1 Score: 351.288 bits (900), Expect = 4.243e-114 Identity = 190/467 (40.69%), Postives = 269/467 (57.60%), Query Frame = 1
Query: 289 PINQSISKISISMVTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMA-YRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGP--IDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVN---FNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKG--EDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWH-----------KYYTCDPQNFDG---KKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTD-LNDMANRLHEFRCRLVINGFNAETMNGGGTYC 1620
P+ ++T DE P E Y + V+ I ++ VWG LRA+++L + Y S I ++D+ RF RG+M+D+SRHFL V I +E+MS++KLNV HWH+VD ESFPY S FP+L G++ HVY+++D+ ++ FAR RGIRV+PEFD PGH+ SW +G+K LT C+ K +F P +DP + + F+++ +EV E FPD LHLGGDEV+ CW+ N +I F + GF ND L+ Y+ KL +V+ L +K+ K + WQEVFDN + +I++WKG ++ +++ +T N+ ++S+CWYLNYI YG DW +YY CDP NF+G +K+LV GG A +WGE VD TN+ +R WPRAS AERLWS T D R+HE RCRLV G+ + N YC
Sbjct: 84 PVEMKTGGTEDFIITVTVKDECPSGPPVHGASEEYLLRVSLTEAVINAQTVWGALRAMESLSHLVFYDHKSQEYQIRTVEIFDKPRFPVRGIMIDSSRHFLSVNVIKRQLEIMSMNKLNVLHWHLVDSESFPYTSVKFPELHGVGAYSP-RHVYSREDIADVIAFARLRGIRVIPEFDLPGHTSSW-RGRKGFLTECFD-EKGVETFLPNLVDPMNEANFDFISEFLEEVTETFPDQFLHLGGDEVSDYIVECWERNKKIRKFMEEKGFGNDTVLLENYFFEKLYKIVENLKLKR---KPIFWQEVFDNN--IPDPNAVIHIWKGNTHEEIYEQVKNITSQNFPVIVSACWYLNYIKYGADWRDEIRGTAPSNSRYYYCDPTNFNGTVAQKELVWGGIAAIWGELVDNTNIEARLWPRASAAAERLWSPAEKTQRAEDAWPRMHELRCRLVSRGYRIQP-NNNPDYC 541
BLAST of Beta-hexosaminidase vs. Ensembl Celegans
Match: hex-1 (Beta-hexosaminidase A [Source:UniProtKB/Swiss-Prot;Acc:Q22492]) HSP 1 Score: 351.288 bits (900), Expect = 4.243e-114 Identity = 190/467 (40.69%), Postives = 269/467 (57.60%), Query Frame = 1
Query: 289 PINQSISKISISMVTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMA-YRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGP--IDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVN---FNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKG--EDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWH-----------KYYTCDPQNFDG---KKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTD-LNDMANRLHEFRCRLVINGFNAETMNGGGTYC 1620
P+ ++T DE P E Y + V+ I ++ VWG LRA+++L + Y S I ++D+ RF RG+M+D+SRHFL V I +E+MS++KLNV HWH+VD ESFPY S FP+L G++ HVY+++D+ ++ FAR RGIRV+PEFD PGH+ SW +G+K LT C+ K +F P +DP + + F+++ +EV E FPD LHLGGDEV+ CW+ N +I F + GF ND L+ Y+ KL +V+ L +K+ K + WQEVFDN + +I++WKG ++ +++ +T N+ ++S+CWYLNYI YG DW +YY CDP NF+G +K+LV GG A +WGE VD TN+ +R WPRAS AERLWS T D R+HE RCRLV G+ + N YC
Sbjct: 84 PVEMKTGGTEDFIITVTVKDECPSGPPVHGASEEYLLRVSLTEAVINAQTVWGALRAMESLSHLVFYDHKSQEYQIRTVEIFDKPRFPVRGIMIDSSRHFLSVNVIKRQLEIMSMNKLNVLHWHLVDSESFPYTSVKFPELHGVGAYSP-RHVYSREDIADVIAFARLRGIRVIPEFDLPGHTSSW-RGRKGFLTECFD-EKGVETFLPNLVDPMNEANFDFISEFLEEVTETFPDQFLHLGGDEVSDYIVECWERNKKIRKFMEEKGFGNDTVLLENYFFEKLYKIVENLKLKR---KPIFWQEVFDNN--IPDPNAVIHIWKGNTHEEIYEQVKNITSQNFPVIVSACWYLNYIKYGADWRDEIRGTAPSNSRYYYCDPTNFNGTVAQKELVWGGIAAIWGELVDNTNIEARLWPRASAAAERLWSPAEKTQRAEDAWPRMHELRCRLVSRGYRIQP-NNNPDYC 541
BLAST of Beta-hexosaminidase vs. Ensembl Celegans
Match: hex-1 (Beta-hexosaminidase A [Source:UniProtKB/Swiss-Prot;Acc:Q22492]) HSP 1 Score: 351.288 bits (900), Expect = 4.243e-114 Identity = 190/467 (40.69%), Postives = 269/467 (57.60%), Query Frame = 1
Query: 289 PINQSISKISISMVTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMA-YRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGP--IDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVN---FNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKG--EDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWH-----------KYYTCDPQNFDG---KKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTD-LNDMANRLHEFRCRLVINGFNAETMNGGGTYC 1620
P+ ++T DE P E Y + V+ I ++ VWG LRA+++L + Y S I ++D+ RF RG+M+D+SRHFL V I +E+MS++KLNV HWH+VD ESFPY S FP+L G++ HVY+++D+ ++ FAR RGIRV+PEFD PGH+ SW +G+K LT C+ K +F P +DP + + F+++ +EV E FPD LHLGGDEV+ CW+ N +I F + GF ND L+ Y+ KL +V+ L +K+ K + WQEVFDN + +I++WKG ++ +++ +T N+ ++S+CWYLNYI YG DW +YY CDP NF+G +K+LV GG A +WGE VD TN+ +R WPRAS AERLWS T D R+HE RCRLV G+ + N YC
Sbjct: 84 PVEMKTGGTEDFIITVTVKDECPSGPPVHGASEEYLLRVSLTEAVINAQTVWGALRAMESLSHLVFYDHKSQEYQIRTVEIFDKPRFPVRGIMIDSSRHFLSVNVIKRQLEIMSMNKLNVLHWHLVDSESFPYTSVKFPELHGVGAYSP-RHVYSREDIADVIAFARLRGIRVIPEFDLPGHTSSW-RGRKGFLTECFD-EKGVETFLPNLVDPMNEANFDFISEFLEEVTETFPDQFLHLGGDEVSDYIVECWERNKKIRKFMEEKGFGNDTVLLENYFFEKLYKIVENLKLKR---KPIFWQEVFDNN--IPDPNAVIHIWKGNTHEEIYEQVKNITSQNFPVIVSACWYLNYIKYGADWRDEIRGTAPSNSRYYYCDPTNFNGTVAQKELVWGGIAAIWGELVDNTNIEARLWPRASAAAERLWSPAEKTQRAEDAWPRMHELRCRLVSRGYRIQP-NNNPDYC 541
BLAST of Beta-hexosaminidase vs. Ensembl Fly
Match: Hexo1 (gene:FBgn0041630 transcript:FBtr0300774) HSP 1 Score: 212.231 bits (539), Expect = 1.650e-60 Identity = 148/472 (31.36%), Postives = 236/472 (50.00%), Query Frame = 1
Query: 289 PINQSISKISISMVTNC-TDDENTKLWPTENMIESYQMEVTKDG-----IFIMSKEVWGILRALQTLFQMAY--RISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKG-QKNLLTPCYSGSKPSGSF------GPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGF---PNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLT----IINVW-KGEDKWQQEMAE----VTKSNYTAVLSSCWYLNYISYG-------IDWHKYYTCDPQNFDGK-KDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETM 1599
P + +++ M N T DE T T + ESY +++ D I + +G L+TL Q+ I + D +++RGL+LDTSR++ V++I +E M++ KLN FHWHI D SFP + K P+L G++ + VYT++DV ++++ R RGIRV+PEFD+P H G+G Q +T C++ ++P SF G +DPT+++ Y L ++ + + F + H+GGDEV+ +CW S+ I + K G+ DF +L G++ + V +A ++W + +D+ L II +W G D +++ E + SNY A+ C +++ G I W K Y ++ G + V+G E +W E +D + +R WPRAS +AERLWSN + +RL R RLV NG AE M
Sbjct: 121 PDRKVLARGGYRMSVNINTPDEPTPARLTLDTDESYTLDIDTDASGHVLANITASNFFGARHGLETLAQLIVYDDIRREVQVTANATINDAPVYKWRGLLLDTSRNYYSVKSIKRTLEGMALVKLNTFHWHITDSHSFPLEVKKRPELHKLGAYSQ-RQVYTRRDVAEVVEYGRVRGIRVMPEFDAPAHV---GEGWQHKNMTACFN-AQPWKSFCVEPPCGQLDPTVNEMYDVLEDIYGTMFDQFNPDIFHMGGDEVSTSCWNSSQPIQQWMKKQGWGLETADFMRLWGHFQTEALGRVDKVA-NGTHTPIILWTSGLTEEPFIDEYLNPERYIIQIWTTGVDPKVKKILERGYKIIVSNYDALYLDCGGAGWVTDGNNWCSPYIGWQKVYDNSLKSIAGDYEHHVLGAEGAIWSEQIDEHTLDNRFWPRASALAERLWSNPA-EGWRQAESRLLLHRQRLVDNGLGAEAM 585
BLAST of Beta-hexosaminidase vs. Ensembl Fly
Match: Hexo1 (gene:FBgn0041630 transcript:FBtr0333567) HSP 1 Score: 212.231 bits (539), Expect = 1.650e-60 Identity = 148/472 (31.36%), Postives = 236/472 (50.00%), Query Frame = 1
Query: 289 PINQSISKISISMVTNC-TDDENTKLWPTENMIESYQMEVTKDG-----IFIMSKEVWGILRALQTLFQMAY--RISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKG-QKNLLTPCYSGSKPSGSF------GPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGF---PNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLT----IINVW-KGEDKWQQEMAE----VTKSNYTAVLSSCWYLNYISYG-------IDWHKYYTCDPQNFDGK-KDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETM 1599
P + +++ M N T DE T T + ESY +++ D I + +G L+TL Q+ I + D +++RGL+LDTSR++ V++I +E M++ KLN FHWHI D SFP + K P+L G++ + VYT++DV ++++ R RGIRV+PEFD+P H G+G Q +T C++ ++P SF G +DPT+++ Y L ++ + + F + H+GGDEV+ +CW S+ I + K G+ DF +L G++ + V +A ++W + +D+ L II +W G D +++ E + SNY A+ C +++ G I W K Y ++ G + V+G E +W E +D + +R WPRAS +AERLWSN + +RL R RLV NG AE M
Sbjct: 121 PDRKVLARGGYRMSVNINTPDEPTPARLTLDTDESYTLDIDTDASGHVLANITASNFFGARHGLETLAQLIVYDDIRREVQVTANATINDAPVYKWRGLLLDTSRNYYSVKSIKRTLEGMALVKLNTFHWHITDSHSFPLEVKKRPELHKLGAYSQ-RQVYTRRDVAEVVEYGRVRGIRVMPEFDAPAHV---GEGWQHKNMTACFN-AQPWKSFCVEPPCGQLDPTVNEMYDVLEDIYGTMFDQFNPDIFHMGGDEVSTSCWNSSQPIQQWMKKQGWGLETADFMRLWGHFQTEALGRVDKVA-NGTHTPIILWTSGLTEEPFIDEYLNPERYIIQIWTTGVDPKVKKILERGYKIIVSNYDALYLDCGGAGWVTDGNNWCSPYIGWQKVYDNSLKSIAGDYEHHVLGAEGAIWSEQIDEHTLDNRFWPRASALAERLWSNPA-EGWRQAESRLLLHRQRLVDNGLGAEAM 585
BLAST of Beta-hexosaminidase vs. Ensembl Fly
Match: Hexo1 (gene:FBgn0041630 transcript:FBtr0073237) HSP 1 Score: 212.231 bits (539), Expect = 1.650e-60 Identity = 148/472 (31.36%), Postives = 236/472 (50.00%), Query Frame = 1
Query: 289 PINQSISKISISMVTNC-TDDENTKLWPTENMIESYQMEVTKDG-----IFIMSKEVWGILRALQTLFQMAY--RISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKG-QKNLLTPCYSGSKPSGSF------GPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGF---PNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLT----IINVW-KGEDKWQQEMAE----VTKSNYTAVLSSCWYLNYISYG-------IDWHKYYTCDPQNFDGK-KDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETM 1599
P + +++ M N T DE T T + ESY +++ D I + +G L+TL Q+ I + D +++RGL+LDTSR++ V++I +E M++ KLN FHWHI D SFP + K P+L G++ + VYT++DV ++++ R RGIRV+PEFD+P H G+G Q +T C++ ++P SF G +DPT+++ Y L ++ + + F + H+GGDEV+ +CW S+ I + K G+ DF +L G++ + V +A ++W + +D+ L II +W G D +++ E + SNY A+ C +++ G I W K Y ++ G + V+G E +W E +D + +R WPRAS +AERLWSN + +RL R RLV NG AE M
Sbjct: 121 PDRKVLARGGYRMSVNINTPDEPTPARLTLDTDESYTLDIDTDASGHVLANITASNFFGARHGLETLAQLIVYDDIRREVQVTANATINDAPVYKWRGLLLDTSRNYYSVKSIKRTLEGMALVKLNTFHWHITDSHSFPLEVKKRPELHKLGAYSQ-RQVYTRRDVAEVVEYGRVRGIRVMPEFDAPAHV---GEGWQHKNMTACFN-AQPWKSFCVEPPCGQLDPTVNEMYDVLEDIYGTMFDQFNPDIFHMGGDEVSTSCWNSSQPIQQWMKKQGWGLETADFMRLWGHFQTEALGRVDKVA-NGTHTPIILWTSGLTEEPFIDEYLNPERYIIQIWTTGVDPKVKKILERGYKIIVSNYDALYLDCGGAGWVTDGNNWCSPYIGWQKVYDNSLKSIAGDYEHHVLGAEGAIWSEQIDEHTLDNRFWPRASALAERLWSNPA-EGWRQAESRLLLHRQRLVDNGLGAEAM 585
BLAST of Beta-hexosaminidase vs. Ensembl Fly
Match: Hexo1 (gene:FBgn0041630 transcript:FBtr0073235) HSP 1 Score: 211.846 bits (538), Expect = 2.726e-60 Identity = 148/472 (31.36%), Postives = 236/472 (50.00%), Query Frame = 1
Query: 289 PINQSISKISISMVTNC-TDDENTKLWPTENMIESYQMEVTKDG-----IFIMSKEVWGILRALQTLFQMAY--RISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKG-QKNLLTPCYSGSKPSGSF------GPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGF---PNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLT----IINVW-KGEDKWQQEMAE----VTKSNYTAVLSSCWYLNYISYG-------IDWHKYYTCDPQNFDGK-KDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETM 1599
P + +++ M N T DE T T + ESY +++ D I + +G L+TL Q+ I + D +++RGL+LDTSR++ V++I +E M++ KLN FHWHI D SFP + K P+L G++ + VYT++DV ++++ R RGIRV+PEFD+P H G+G Q +T C++ ++P SF G +DPT+++ Y L ++ + + F + H+GGDEV+ +CW S+ I + K G+ DF +L G++ + V +A ++W + +D+ L II +W G D +++ E + SNY A+ C +++ G I W K Y ++ G + V+G E +W E +D + +R WPRAS +AERLWSN + +RL R RLV NG AE M
Sbjct: 121 PDRKVLARGGYRMSVNINTPDEPTPARLTLDTDESYTLDIDTDASGHVLANITASNFFGARHGLETLAQLIVYDDIRREVQVTANATINDAPVYKWRGLLLDTSRNYYSVKSIKRTLEGMALVKLNTFHWHITDSHSFPLEVKKRPELHKLGAYSQ-RQVYTRRDVAEVVEYGRVRGIRVMPEFDAPAHV---GEGWQHKNMTACFN-AQPWKSFCVEPPCGQLDPTVNEMYDVLEDIYGTMFDQFNPDIFHMGGDEVSTSCWNSSQPIQQWMKKQGWGLETADFMRLWGHFQTEALGRVDKVA-NGTHTPIILWTSGLTEEPFIDEYLNPERYIIQIWTTGVDPKVKKILERGYKIIVSNYDALYLDCGGAGWVTDGNNWCSPYIGWQKVYDNSLKSIAGDYEHHVLGAEGAIWSEQIDEHTLDNRFWPRASALAERLWSNPA-EGWRQAESRLLLHRQRLVDNGLGAEAM 585
BLAST of Beta-hexosaminidase vs. Ensembl Fly
Match: Hexo2 (gene:FBgn0041629 transcript:FBtr0071249) HSP 1 Score: 201.83 bits (512), Expect = 1.266e-56 Identity = 138/450 (30.67%), Postives = 224/450 (49.78%), Query Frame = 1
Query: 364 WPTENMIESYQMEV--TKDGIF--IMSKEVWGILRALQTLFQMAY-RISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHS---LSWG--KGQKNLLTPCYSGS--------KPSGSFGPIDPTLDQTYTFLNKLFKEVIEI-FPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGF---PNDFAKLQGYYMIKLTNLVQGLAVK-----KKDFKTMVWQEVFDNKNEVDQKLT----IINVW-KGEDKWQQEMAEVTKSNYTAVLSS--CWYLNYISYG----IDWHKYYTCDPQNFDGKKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETM 1599
WPT+ ESY + V T+ F I + V+G A +TL + +S+G L + + D+ F RG++LDT+R+F+P++ I ++ M+ SKLNV HWH+VD SFP + P++ G++ S Y+++D L ++ +AR RGIR++ E D P H+ WG G N ++ C + S P G P++ D Y L ++F++V E+ P+ LH+GGDEV CW + I + G+ F +L + + N + + K+ ++W N ++ L II W + +D +E+ + Y ++S+ WYL++ +G +W Y+ KD V+GGE CMW EYVD ++ SR WPRA AER+WSN + L R + +R RL+ G +A+ +
Sbjct: 173 WPTD---ESYALVVRTTETATFVDIQATTVYGARHAFETLSNLVTGSLSNGLLMVTTANITDRPAFSHRGVLLDTARNFVPLKFIRSTLDAMAASKLNVLHWHVVDTHSFPLEITRVPEMQRYGAYSS-SQTYSRQDALNLVKYARLRGIRILIEIDGPSHAGNGWQWGPAAGLGN-MSVCLNQSPWRRFCVQPPCGQLNPLN---DHMYAVLKEIFEDVAEVGAPEETLHMGGDEVFLPCWNNTDEIRDGMRARGYDLSEQSFLRLWSQFHQRNLNAWDEINERMYPGIKEPKSVIIWSSHLTNPRYIETYLPKERFIIQTWVESQDALNREL---LQRGYRLIVSTKNAWYLDHGFWGSTSYYNWRTVYSSG-MPVGRSKDQVLGGEVCMWSEYVDQNSLESRIWPRAGAAAERMWSNPKSSALL-AQRRFYRYRERLLARGIHADAV 609
BLAST of Beta-hexosaminidase vs. Ensembl Zebrafish
Match: hexa (hexosaminidase A (alpha polypeptide) [Source:ZFIN;Acc:ZDB-GENE-050417-283]) HSP 1 Score: 482.256 bits (1240), Expect = 3.787e-165 Identity = 237/477 (49.69%), Postives = 318/477 (66.67%), Query Frame = 1
Query: 214 CNLLNDAIKR--------FTKYLYNSIYINYEGPINQSISKISISMVTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGEDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDG---KKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMA-NRLHEFRCRLVINGFNAETMNGG 1608
C++L+ A KR FTK + +++ + + +S+S+ T D +P E+ ESY + V++ + S VWG LR L++ Q+ YR GA +N+T + D RF FRGL+LDTSRH+LP+ IL ++ M+ SK NVFHWHIVDD SFPYQS+TFPDLS KG+FH F+H+YTQ DV+R+++ AR RGIRVVPEFDSPGH+ SWGKGQ +LLTPCY GSKPSG++GP+DPT+D TY F+ +L KEV +FPD+ +HLGGDEV+F CW+SNP + F K GF DF KL+ +YM + N+ L + ++VWQ+VFD + Q T++ +WKGE +Q E++++TK+ + +LS+ WY+N+I+YG DW Y PQNF G +K LVIGGE MWGEYVDATN+ R WPRA AERLWSN+ T D+A RL EFRC LV G AE + G
Sbjct: 65 CSVLDTAFKRYFSIIFPDFTKDALHDMWLEPKAFV------LSVSVKTRGCDG-----YPDEDSDESYNLSVSEGQAVLRSVTVWGALRGLESFSQLVYRDDYGAYFVNKTEIVDFPRFAFRGLLLDTSRHYLPLHAILKTLDAMAYSKFNVFHWHIVDDPSFPYQSRTFPDLSKKGAFHPFTHIYTQSDVMRVIEHARMRGIRVVPEFDSPGHTQSWGKGQPDLLTPCYKGSKPSGTYGPVDPTVDTTYRFMERLLKEVKFVFPDSYVHLGGDEVSFACWQSNPSVGKFMEKMGFGRDFTKLESFYMESIMNITAAL-----NKTSIVWQDVFDYHERIPQG-TVLEIWKGE-TYQTELSKMTKAGHRVLLSAPWYINHITYGQDWRNSYAVQPQNFSGTEEQKKLVIGGEVAMWGEYVDATNLNPRLWPRACAAAERLWSNEEKTLNADLAFPRLEEFRCELVRRGIQAEPLFVG 523
BLAST of Beta-hexosaminidase vs. Ensembl Zebrafish
Match: hexb (hexosaminidase B (beta polypeptide) [Source:ZFIN;Acc:ZDB-GENE-030131-2333]) HSP 1 Score: 460.299 bits (1183), Expect = 1.805e-156 Identity = 239/503 (47.51%), Postives = 330/503 (65.61%), Query Frame = 1
Query: 127 PLPKPFYIYSGGNVFNL------VENIKIQNPYPQCNLLNDAIKRFTKYLYNSIYINYEGPINQSISKISISMVTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGEDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNF---DGKKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETMNGG 1608
PLP+ + S F L + + K P C+LL +A +R+ +Y++ + + S +S V + D +P+ ESY + V + + + VWG LR L+T Q+ Y G IN+T + D RF RG++LD+SRHFLP++ IL N+E M+++K NVFHWHIVDD SFP+ S+TFP+LS KG++H F+HVYT DV +++FAR RGIRVV EFD+PGH+ SWG G K+LLTPCYSGS PSGSFGP++P L+ +Y F+ +LFKE+ +FPD +HLGGDEV+F+CWKSNP I F + GF D++KL+ +Y+ +L ++V A KK + MVWQEVFDN ++ T++ VWKG D ++E+ VT + +T +LS+ WYL+YISYG DW +YY +P +F D +K LVIGGEAC+WGEYVDATN+ R WPRAS VAERLWS+ SVTD+ + RL + RCR+V G AE + G
Sbjct: 39 PLPQKYQ--SSAVAFKLSAASFQIVHAKQSTAGPSCSLLENAFRRYFEYMFGELKRQEKSRKKAFDSDLSELQVWITSADPECDGYPSLRTDESYSLSVDETSAVLKAANVWGALRGLETFSQLVYEDDYGVRNINKTDISDFPRFAHRGILLDSSRHFLPLKVILANLEAMAMNKFNVFHWHIVDDPSFPFMSRTFPELSQKGAYHPFTHVYTPSDVKMVIEFARMRGIRVVAEFDTPGHTQSWGNGIKDLLTPCYSGSSPSGSFGPVNPILNSSYEFMAQLFKEISTVFPDAYIHLGGDEVDFSCWKSNPDIQKFMNQQGFGTDYSKLESFYIQRLLDIV---AATKKGY--MVWQEVFDNGVKLKDD-TVVEVWKGNDM-KEELQNVTGAGFTTILSAPWYLDYISYGQDWQRYYKVEPLDFTGTDAQKKLVIGGEACLWGEYVDATNLTPRLWPRASAVAERLWSDASVTDVGNAYTRLAQHRCRMVRRGIPAEPLFVG 532
BLAST of Beta-hexosaminidase vs. Ensembl Zebrafish
Match: hexa (hexosaminidase A (alpha polypeptide) [Source:ZFIN;Acc:ZDB-GENE-050417-283]) HSP 1 Score: 449.129 bits (1154), Expect = 2.591e-152 Identity = 229/477 (48.01%), Postives = 307/477 (64.36%), Query Frame = 1
Query: 214 CNLLNDAIKR--------FTKYLYNSIYINYEGPINQSISKISISMVTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGEDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDG---KKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMA-NRLHEFRCRLVINGFNAETMNGG 1608
C++L+ A KR FTK + +++ + + +S+S+ T D +P E+ ESY + V++ + S VWG LR L++ Q+ YR GA +N+T + D RF FRGL+LDTSRH+LP+ IL ++ M+ SK NVFHWHIVDD SFPYQS+TFPDLS KG+FH F+H+YTQ DV+R+++ AR RGIRVVPEFDSPGH+ SWGKGQ +LLTPCY GSKPSG++GP+DPT+D TY F+ +L KEV +FPD+ +HLGGDEV+F CW SNP + F K GF DF KL+ +YM + N+ L + ++VWQ+VFD +E + ++ VWK + + EM VTK+ +L++ +YL+ +W +YY P F G +K LVIGGE MWGEYVDATN+ R WPRA AERLWSN+ T D+A RL EFRC LV G AE + G
Sbjct: 65 CSVLDTAFKRYFSIIFPDFTKDALHDMWLEPKAFV------LSVSVKTRGCDG-----YPDEDSDESYNLSVSEGQAVLRSVTVWGALRGLESFSQLVYRDDYGAYFVNKTEIVDFPRFAFRGLLLDTSRHYLPLHAILKTLDAMAYSKFNVFHWHIVDDPSFPYQSRTFPDLSKKGAFHPFTHIYTQSDVMRVIEHARMRGIRVVPEFDSPGHTQSWGKGQPDLLTPCYKGSKPSGTYGPVDPTVDTTYRFMERLLKEVKFVFPDSYVHLGGDEVSFACWYSNPSVGKFMEKMGFGRDFTKLESFYMESIMNITAAL-----NKTSIVWQDVFDY-HERPRSQYVVEVWK-QGCYLCEMRRVTKAGLKVILAAPFYLDLPIPTQNWARYYGVRPLAFRGTEEQKKLVIGGEVAMWGEYVDATNLNPRLWPRACAAAERLWSNEEKTLNADLAFPRLEEFRCELVRRGIQAEPLFVG 523
BLAST of Beta-hexosaminidase vs. Ensembl Zebrafish
Match: hexb (hexosaminidase B (beta polypeptide) [Source:ZFIN;Acc:ZDB-GENE-030131-2333]) HSP 1 Score: 369.392 bits (947), Expect = 4.529e-122 Identity = 194/428 (45.33%), Postives = 277/428 (64.72%), Query Frame = 1
Query: 127 PLPKPFYIYSGGNVFNL------VENIKIQNPYPQCNLLNDAIKRFTKYLYNSIYINYEGPINQSISKISISMVTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGEDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDGK 1392
PLP+ + S F L + + K P C+LL +A +R+ +Y++ + + S +S V + D +P+ ESY + V + + + VWG LR L+T Q+ Y G IN+T + D RF RG++LD+SRHFLP++ IL N+E M+++K NVFHWHIVDD SFP+ S+TFP+LS KG++H F+HVYT DV +++FAR RGIRVV EFD+PGH+ SWG G K+LLTPCYSGS PSGSFGP++P L+ +Y F+ +LFKE+ +FPD +HLGGDEV+F+CWKSNP I F + GF D++KL+ +Y+ +L ++V A KK + MVWQEVFDN ++ T++ VWKG D ++E+ VT + +T +LS+ WYL+YISYG DW +YY +P +F G+
Sbjct: 39 PLPQKYQ--SSAVAFKLSAASFQIVHAKQSTAGPSCSLLENAFRRYFEYMFGELKRQEKSRKKAFDSDLSELQVWITSADPECDGYPSLRTDESYSLSVDETSAVLKAANVWGALRGLETFSQLVYEDDYGVRNINKTDISDFPRFAHRGILLDSSRHFLPLKVILANLEAMAMNKFNVFHWHIVDDPSFPFMSRTFPELSQKGAYHPFTHVYTPSDVKMVIEFARMRGIRVVAEFDTPGHTQSWGNGIKDLLTPCYSGSSPSGSFGPVNPILNSSYEFMAQLFKEISTVFPDAYIHLGGDEVDFSCWKSNPDIQKFMNQQGFGTDYSKLESFYIQRLLDIV---AATKKGY--MVWQEVFDNGVKLKDD-TVVEVWKGNDM-KEELQNVTGAGFTTILSAPWYLDYISYGQDWQRYYKVEPLDFTGQ 457
BLAST of Beta-hexosaminidase vs. Ensembl Zebrafish
Match: hexb (hexosaminidase B (beta polypeptide) [Source:ZFIN;Acc:ZDB-GENE-030131-2333]) HSP 1 Score: 298.13 bits (762), Expect = 5.245e-97 Identity = 154/272 (56.62%), Postives = 200/272 (73.53%), Query Frame = 1
Query: 793 GIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGEDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDG---KKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETM 1599
GIRVV EFD+PGH+ SWG G K+LLTPCYSGS PSGSFGP++P L+ +Y F+ +LFKE+ +FPD +HLGGDEV+F+CWKSNP I F + GF D++KL+ +Y+ +L ++V A KK + MVWQEVFDN ++ T I+VWKG ++Q EMA+VT + ++A+LS+ WYLN +SYG DW Y DPQNF+G +K LVIGGEAC+WGEYVDATN+ R WPRAS VAERLWS+ SVTD+ + RL + RCR+V G AE +
Sbjct: 2 GIRVVAEFDTPGHTQSWGNGIKDLLTPCYSGSSPSGSFGPVNPILNSSYEFMAQLFKEISTVFPDAYIHLGGDEVDFSCWKSNPDIQKFMNQQGFGTDYSKLESFYIQRLLDIV---AATKKGY--MVWQEVFDNGVKLKAD-TQIHVWKGRPQYQDEMAKVTAAGFSALLSTPWYLNRVSYGQDWVDIYKADPQNFNGTDAQKKLVIGGEACLWGEYVDATNLTPRLWPRASAVAERLWSDASVTDVGNAYTRLAQHRCRMVRRGIPAEPL 267
BLAST of Beta-hexosaminidase vs. Ensembl Xenopus
Match: hexb (hexosaminidase B (beta polypeptide) [Source:NCBI gene;Acc:100145770]) HSP 1 Score: 481.1 bits (1237), Expect = 2.694e-164 Identity = 235/473 (49.68%), Postives = 319/473 (67.44%), Query Frame = 1
Query: 214 CNLLNDAIKRFTKYLYNSIYINYEGPINQSISKISISMVTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGEDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDG---KKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETMNGGGTYCN 1623
C LL A +R+ Y++ + ++ V + D +PT ESY++ V ++ + + +VWG LR L+T Q+ Y GA IN++ + D RF RG++LDTSRH+LP++TI N++ M+ +K NVFHWHIVDD SFPYQS TFPDLSDKGS+H ++HVYT DV ++++AR RGIRVVPEFDSPGH+ SWGKGQ+NLLTPC++ + SG++GP++P L+ TY F+ F+E+ +FPD +HLGGDEV+F+CWKSNP + F +GF D+ KL+ YY+ ++ +V L KK + MVWQEVFDN +++ TII VWK E +Q+EMA VT + + A+LSS WYLN ISYG DW + Y +P NF+G +K LVIGGEACMWGE+VDATN+ R WPRAS VAERLWSNQ+VT + D NRL + RCR++ G AE + G YC+
Sbjct: 87 CVLLQSAFRRYYDYMFGYSKWKRASAKPSNAGQLLQLQVVILSKDHQCHRYPTVQSDESYELSVGENVAVLKANQVWGALRGLETFSQLIYEDRFGAFLINKSYIEDFPRFAHRGILLDTSRHYLPLKTIFLNLDAMAFNKFNVFHWHIVDDPSFPYQSVTFPDLSDKGSYHPYTHVYTPVDVRLVIEYARMRGIRVVPEFDSPGHTDSWGKGQQNLLTPCFNKGQLSGAYGPVNPILNDTYNFMYTFFQEISNVFPDQYIHLGGDEVDFSCWKSNPDVTKFMTDHGFGTDYCKLESYYIQQVLGIVSSL---KKGY--MVWQEVFDNNVKLNPD-TIIEVWK-EQLYQEEMAAVTAAGFQALLSSPWYLNRISYGQDWIQVYKVEPANFNGTAEQKQLVIGGEACMWGEFVDATNLTPRLWPRASAVAERLWSNQNVTSVGDAYNRLVKHRCRMLRRGIAAEPLYVG--YCD 550
BLAST of Beta-hexosaminidase vs. Ensembl Xenopus
Match: hexb (hexosaminidase B (beta polypeptide) [Source:NCBI gene;Acc:100145770]) HSP 1 Score: 477.633 bits (1228), Expect = 7.457e-163 Identity = 228/473 (48.20%), Postives = 321/473 (67.86%), Query Frame = 1
Query: 214 CNLLNDAIKRFTKYLYNSIYINYEGPINQSISKISISMVTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGEDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDG---KKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETMNGGGTYCN 1623
C LL A +R+ Y++ + ++ V + D +PT ESY++ V ++ + + +VWG LR L+T Q+ Y GA IN++ + D RF RG++LDTSRH+LP++TI N++ M+ +K NVFHWHIVDD SFPYQS TFPDLSDKGS+H ++HVYT DV ++++AR RGIRVVPEFDSPGH+ SWGKGQ+NLLTPC++ + SG++GP++P L+ TY F+ F+E+ +FPD +HLGGDEV+F+CWKSNP + F +GF D+ KL+ YY+ ++ +V L KK + MVWQEVFDN +++ TI+ VW G++ + +E+ +VT + + A++++ WYL+YISYG DW KYY +P +F+G +K LVIGGEACMWGE+VDATN+ R WPRAS VAERLWSNQ+VT + D NRL + RCR++ G AE + G YC+
Sbjct: 87 CVLLQSAFRRYYDYMFGYSKWKRASAKPSNAGQLLQLQVVILSKDHQCHRYPTVQSDESYELSVGENVAVLKANQVWGALRGLETFSQLIYEDRFGAFLINKSYIEDFPRFAHRGILLDTSRHYLPLKTIFLNLDAMAFNKFNVFHWHIVDDPSFPYQSVTFPDLSDKGSYHPYTHVYTPVDVRLVIEYARMRGIRVVPEFDSPGHTDSWGKGQQNLLTPCFNKGQLSGAYGPVNPILNDTYNFMYTFFQEISNVFPDQYIHLGGDEVDFSCWKSNPDVTKFMTDHGFGTDYCKLESYYIQQVLGIVSSL---KKGY--MVWQEVFDNNVKINPD-TIVEVWMGQNCY-EELYKVTAAGFPAIMAAPWYLDYISYGQDWQKYYKVEPLSFNGTAEQKQLVIGGEACMWGEFVDATNLTPRLWPRASAVAERLWSNQNVTSVGDAYNRLVKHRCRMLRRGIAAEPLYVG--YCD 550
BLAST of Beta-hexosaminidase vs. Ensembl Xenopus
Match: hexb (hexosaminidase B (beta polypeptide) [Source:NCBI gene;Acc:100145770]) HSP 1 Score: 468.003 bits (1203), Expect = 1.320e-160 Identity = 223/436 (51.15%), Postives = 308/436 (70.64%), Query Frame = 1
Query: 328 VTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGEDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDP-QNFDG---KKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETMNGGGTYCN 1623
V + D +PT ESY++ V ++ + + +VWG LR L+T Q+ Y GA IN++ + D RF RG++LDTSRH+LP++TI N++ M+ +K NVFHWHIVDD SFPYQS TFPDLSDKGS+H ++HVYT DV ++++AR RGIRVVPEFDSPGH+ SWGKGQ+NLLTPC++ + SG++GP++P L+ TY F+ F+E+ +FPD +HLGGDEV+F+CWKSNP + F +GF D+ KL+ YY+ ++ +V L KK + MVWQEVFDN +++ TI+ VW G++ + +E+ +VT + + A++++ WYL+YISYG DW KYY +P NF+G +K LVIGGEACMWGE+VDATN+ R WPRAS VAERLWSNQ+VT + D NRL + RCR++ G AE + G YC+
Sbjct: 25 VVILSKDHQCHRYPTVQSDESYELSVGENVAVLKANQVWGALRGLETFSQLIYEDRFGAFLINKSYIEDFPRFAHRGILLDTSRHYLPLKTIFLNLDAMAFNKFNVFHWHIVDDPSFPYQSVTFPDLSDKGSYHPYTHVYTPVDVRLVIEYARMRGIRVVPEFDSPGHTDSWGKGQQNLLTPCFNKGQLSGAYGPVNPILNDTYNFMYTFFQEISNVFPDQYIHLGGDEVDFSCWKSNPDVTKFMTDHGFGTDYCKLESYYIQQVLGIVSSL---KKGY--MVWQEVFDNNVKINPD-TIVEVWMGQNCY-EELYKVTAAGFPAIMAAPWYLDYISYGQDWQKYYKVEPLTNFNGTAEQKQLVIGGEACMWGEFVDATNLTPRLWPRASAVAERLWSNQNVTSVGDAYNRLVKHRCRMLRRGIAAEPLYVG--YCD 451
BLAST of Beta-hexosaminidase vs. Ensembl Xenopus
Match: hexb (hexosaminidase B (beta polypeptide) [Source:NCBI gene;Acc:100145770]) HSP 1 Score: 460.299 bits (1183), Expect = 1.443e-156 Identity = 223/473 (47.15%), Postives = 315/473 (66.60%), Query Frame = 1
Query: 214 CNLLNDAIKRFTKYLYNSIYINYEGPINQSISKISISMVTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGEDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDG---KKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETMNGGGTYCN 1623
C LL A +R+ Y++ + ++ V + D +PT ESY++ V ++ + + +VWG LR + S IN++ + D RF RG++LDTSRH+LP++TI N++ M+ +K NVFHWHIVDD SFPYQS TFPDLSDKGS+H ++HVYT DV ++++AR RGIRVVPEFDSPGH+ SWGKGQ+NLLTPC++ + SG++GP++P L+ TY F+ F+E+ +FPD +HLGGDEV+F+CWKSNP + F +GF D+ KL+ YY+ ++ +V L KK + MVWQEVFDN +++ TI+ VW G++ + +E+ +VT + + A++++ WYL+YISYG DW KYY +P +F+G +K LVIGGEACMWGE+VDATN+ R WPRAS VAERLWSNQ+VT + D NRL + RCR++ G AE + G YC+
Sbjct: 62 CVLLQSAFRRYYDYMFGYSKWKRASAKPSNAGQLLQLQVVILSKDHQCHRYPTVQSDESYELSVGENVAVLKANQVWGALRGYFFIPPKFILCSVKQFLINKSYIEDFPRFAHRGILLDTSRHYLPLKTIFLNLDAMAFNKFNVFHWHIVDDPSFPYQSVTFPDLSDKGSYHPYTHVYTPVDVRLVIEYARMRGIRVVPEFDSPGHTDSWGKGQQNLLTPCFNKGQLSGAYGPVNPILNDTYNFMYTFFQEISNVFPDQYIHLGGDEVDFSCWKSNPDVTKFMTDHGFGTDYCKLESYYIQQVLGIVSSL---KKGY--MVWQEVFDNNVKINPD-TIVEVWMGQNCY-EELYKVTAAGFPAIMAAPWYLDYISYGQDWQKYYKVEPLSFNGTAEQKQLVIGGEACMWGEFVDATNLTPRLWPRASAVAERLWSNQNVTSVGDAYNRLVKHRCRMLRRGIAAEPLYVG--YCD 525
BLAST of Beta-hexosaminidase vs. Ensembl Xenopus
Match: hexb (hexosaminidase B (beta polypeptide) [Source:NCBI gene;Acc:100145770]) HSP 1 Score: 460.685 bits (1184), Expect = 2.601e-156 Identity = 223/473 (47.15%), Postives = 315/473 (66.60%), Query Frame = 1
Query: 214 CNLLNDAIKRFTKYLYNSIYINYEGPINQSISKISISMVTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGEDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDG---KKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETMNGGGTYCN 1623
C LL A +R+ Y++ + ++ V + D +PT ESY++ V ++ + + +VWG LR + S IN++ + D RF RG++LDTSRH+LP++TI N++ M+ +K NVFHWHIVDD SFPYQS TFPDLSDKGS+H ++HVYT DV ++++AR RGIRVVPEFDSPGH+ SWGKGQ+NLLTPC++ + SG++GP++P L+ TY F+ F+E+ +FPD +HLGGDEV+F+CWKSNP + F +GF D+ KL+ YY+ ++ +V L KK + MVWQEVFDN +++ TI+ VW G++ + +E+ +VT + + A++++ WYL+YISYG DW KYY +P +F+G +K LVIGGEACMWGE+VDATN+ R WPRAS VAERLWSNQ+VT + D NRL + RCR++ G AE + G YC+
Sbjct: 87 CVLLQSAFRRYYDYMFGYSKWKRASAKPSNAGQLLQLQVVILSKDHQCHRYPTVQSDESYELSVGENVAVLKANQVWGALRGYFFIPPKFILCSVKQFLINKSYIEDFPRFAHRGILLDTSRHYLPLKTIFLNLDAMAFNKFNVFHWHIVDDPSFPYQSVTFPDLSDKGSYHPYTHVYTPVDVRLVIEYARMRGIRVVPEFDSPGHTDSWGKGQQNLLTPCFNKGQLSGAYGPVNPILNDTYNFMYTFFQEISNVFPDQYIHLGGDEVDFSCWKSNPDVTKFMTDHGFGTDYCKLESYYIQQVLGIVSSL---KKGY--MVWQEVFDNNVKINPD-TIVEVWMGQNCY-EELYKVTAAGFPAIMAAPWYLDYISYGQDWQKYYKVEPLSFNGTAEQKQLVIGGEACMWGEFVDATNLTPRLWPRASAVAERLWSNQNVTSVGDAYNRLVKHRCRMLRRGIAAEPLYVG--YCD 550
BLAST of Beta-hexosaminidase vs. Ensembl Mouse
Match: Hexb (hexosaminidase B [Source:MGI Symbol;Acc:MGI:96074]) HSP 1 Score: 478.789 bits (1231), Expect = 1.076e-163 Identity = 231/480 (48.12%), Postives = 318/480 (66.25%), Query Frame = 1
Query: 208 PQCNLLNDAIKRFTKYLYNSIYINYEGPINQSISKISISMVTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGEDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDG---KKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETMNGGGTYCNIPGEI 1638
P C+LL +A +R+ Y++ Y + GP ++ + T + + +P+ + E+Y + V + + + VWG LR L+T Q+ Y+ S G INE+ + D RF RG+++DTSRHFLPV+TIL ++ M+ +K NV HWHIVDD+SFPYQS TFP+LS+KGS+ SHVYT DV +L++AR RGIRV+PEFD+PGH+ SWGKGQKNLLTPCY+ + FGP+DPT++ TY F N FKE+ +FPD +HLGGDEV F CW SNP I F + GF +DF +L+ +Y+ K+ ++ L KK+ ++VWQEVFD+K E+ Q T++ VWK E + E+ +VT S + A+LS+ WYL+ ISYG DW YY +P NF+G +K LVIGGEAC+WGE+VDATN+ R WPRAS V ERLWS ++VTDL + RL RCR+V G A+ + G YCN +I
Sbjct: 68 PSCSLLQEAFRRYYNYVFG-FYKRHHGPARFRAEPQLQKLLVSITLESECESFPSLSSDETYSLLVQEPVAVLKANSVWGALRGLETFSQLVYQDSFGTFTINESSIADSPRFPHRGILIDTSRHFLPVKTILKTLDAMAFNKFNVLHWHIVDDQSFPYQSTTFPELSNKGSY-SLSHVYTPNDVRMVLEYARLRGIRVIPEFDTPGHTQSWGKGQKNLLTPCYNQKTKTQVFGPVDPTVNTTYAFFNTFFKEISSVFPDQFIHLGGDEVEFQCWASNPNIQGFMKRKGFGSDFRRLESFYIKKILEIISSL---KKN--SIVWQEVFDDKVEL-QPGTVVEVWKSE-HYSYELKQVTGSGFPAILSAPWYLDLISYGQDWKNYYKVEPLNFEGSEKQKQLVIGGEACLWGEFVDATNLTPRLWPRASAVGERLWSPKTVTDLENAYKRLAVHRCRMVSRGIAAQPLYTG--YCNYENKI 536
BLAST of Beta-hexosaminidase vs. Ensembl Mouse
Match: Hexa (hexosaminidase A [Source:MGI Symbol;Acc:MGI:96073]) HSP 1 Score: 441.81 bits (1135), Expect = 1.747e-149 Identity = 219/480 (45.62%), Postives = 314/480 (65.42%), Query Frame = 1
Query: 214 CNLLNDAIKRFTKYLYNS------IYINYEGPINQSISKISISMVTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGED--KWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDG---KKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETMNGGGTYC 1620
C +L++A +R+ L+ S + N + + ++I +S+ + C + +P +E+Y + + D + S+ VWG LR L+T Q+ ++ + G IN+T + D RF RG++LDTSRH+LP+ +ILD +++M+ +K NVFHWH+VDD SFPY+S TFP+L+ KGSF+ +H+YT +DV ++++AR RGIRV+ EFD+PGH+LSWG G LLTPCYSGS SG+FGP++P+L+ TY F++ LF E+ +FPD LHLGGDEV+F CWKSNP I F K GF DF +L+ +Y+ L ++V D +VWQEVFDNK +V TII VW+ E ++ EM ++T++ + A+LS+ WYLN + YG DW Y +P F G +K LVIGGEACMWGEYVD+TN++ R WPRA VAERLWS+ T+++ RL FRC LV G A+ ++ G YC
Sbjct: 58 CVVLDEAFRRYRNLLFGSGSWPRPSFSNKQQTLGKNILVVSV-VTAECNE------FPNLESVENYTLTINDDQCLLASETVWGALRGLETFSQLVWKSAEGTFFINKTKIKDFPRFPHRGVLLDTSRHYLPLSSILDTLDVMAYNKFNVFHWHLVDDSSFPYESFTFPELTRKGSFNPVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGPGAPGLLTPCYSGSHLSGTFGPVNPSLNSTYDFMSTLFLEISSVFPDFYLHLGGDEVDFTCWKSNPNIQAFMKKKGF-TDFKQLESFYIQTLLDIVSDY-----DKGYVVWQEVFDNKVKVRPD-TIIQVWREEMPVEYMLEMQDITRAGFRALLSAPWYLNRVKYGPDWKDMYKVEPLAFHGTPEQKALVIGGEACMWGEYVDSTNLVPRLWPRAGAVAERLWSSNLTTNIDFAFKRLSHFRCELVRRGIQAQPISVG--YC 521
BLAST of Beta-hexosaminidase vs. UniProt/SwissProt
Match: sp|P20060|HEXB_MOUSE (Beta-hexosaminidase subunit beta OS=Mus musculus OX=10090 GN=Hexb PE=1 SV=2) HSP 1 Score: 478.789 bits (1231), Expect = 7.527e-163 Identity = 231/480 (48.12%), Postives = 318/480 (66.25%), Query Frame = 1
Query: 208 PQCNLLNDAIKRFTKYLYNSIYINYEGPINQSISKISISMVTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGEDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDG---KKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETMNGGGTYCNIPGEI 1638
P C+LL +A +R+ Y++ Y + GP ++ + T + + +P+ + E+Y + V + + + VWG LR L+T Q+ Y+ S G INE+ + D RF RG+++DTSRHFLPV+TIL ++ M+ +K NV HWHIVDD+SFPYQS TFP+LS+KGS+ SHVYT DV +L++AR RGIRV+PEFD+PGH+ SWGKGQKNLLTPCY+ + FGP+DPT++ TY F N FKE+ +FPD +HLGGDEV F CW SNP I F + GF +DF +L+ +Y+ K+ ++ L KK+ ++VWQEVFD+K E+ Q T++ VWK E + E+ +VT S + A+LS+ WYL+ ISYG DW YY +P NF+G +K LVIGGEAC+WGE+VDATN+ R WPRAS V ERLWS ++VTDL + RL RCR+V G A+ + G YCN +I
Sbjct: 68 PSCSLLQEAFRRYYNYVFG-FYKRHHGPARFRAEPQLQKLLVSITLESECESFPSLSSDETYSLLVQEPVAVLKANSVWGALRGLETFSQLVYQDSFGTFTINESSIADSPRFPHRGILIDTSRHFLPVKTILKTLDAMAFNKFNVLHWHIVDDQSFPYQSTTFPELSNKGSY-SLSHVYTPNDVRMVLEYARLRGIRVIPEFDTPGHTQSWGKGQKNLLTPCYNQKTKTQVFGPVDPTVNTTYAFFNTFFKEISSVFPDQFIHLGGDEVEFQCWASNPNIQGFMKRKGFGSDFRRLESFYIKKILEIISSL---KKN--SIVWQEVFDDKVEL-QPGTVVEVWKSE-HYSYELKQVTGSGFPAILSAPWYLDLISYGQDWKNYYKVEPLNFEGSEKQKQLVIGGEACLWGEFVDATNLTPRLWPRASAVGERLWSPKTVTDLENAYKRLAVHRCRMVSRGIAAQPLYTG--YCNYENKI 536
BLAST of Beta-hexosaminidase vs. UniProt/SwissProt
Match: sp|P07686|HEXB_HUMAN (Beta-hexosaminidase subunit beta OS=Homo sapiens OX=9606 GN=HEXB PE=1 SV=3) HSP 1 Score: 471.085 bits (1211), Expect = 1.215e-159 Identity = 232/506 (45.85%), Postives = 329/506 (65.02%), Query Frame = 1
Query: 133 PKPFYIYSGGNVFNLV-ENIKIQN-----PYPQCNLLNDAIKRFTKYLYNSIYINYEGPINQSISKISISMVTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGEDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDG---KKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETMNGGGTYCN 1623
P P + N+ +L EN I + P C LL +A +R+ Y++ ++E Q+ +++ ++ + T +P + ESY + V + + + VWG LR L+T Q+ Y+ S G INE+ + D RF RG+++DTSRH+LPV+ IL ++ M+ +K NV HWHIVDD+SFPYQS TFP+LS+KGS+ SHVYT DV ++++AR RGIRV+PEFD+PGH+LSWGKGQK+LLTPCYS SFGPI+PTL+ TY+FL FKE+ E+FPD +HLGGDEV F CW+SNP+I +F + GF DF KL+ +Y+ K+ +++ + + ++VWQEVFD+K ++ TI+ VWK + + +E++ VT S + +LS+ WYL+ ISYG DW KYY +P +F G +K L IGGEAC+WGEYVDATN+ R WPRAS V ERLWS++ V D++D +RL RCR+V G A+ + G YCN
Sbjct: 58 PLPLSVKMTPNLLHLAPENFYISHSPNSTAGPSCTLLEEAFRRYHGYIFGFYKWHHEPAEFQAKTQVQ-QLLVSITLQSECDAFPNISSDESYTLLVKEPVAVLKANRVWGALRGLETFSQLVYQDSYGTFTINESTIIDSPRFSHRGILIDTSRHYLPVKIILKTLDAMAFNKFNVLHWHIVDDQSFPYQSITFPELSNKGSY-SLSHVYTPNDVRMVIEYARLRGIRVLPEFDTPGHTLSWGKGQKDLLTPCYSRQNKLDSFGPINPTLNTTYSFLTTFFKEISEVFPDQFIHLGGDEVEFKCWESNPKIQDFMRQKGFGTDFKKLESFYIQKVLDIIATI-----NKGSIVWQEVFDDKAKLAPG-TIVEVWK-DSAYPEELSRVTASGFPVILSAPWYLDLISYGQDWRKYYKVEPLDFGGTQKQKQLFIGGEACLWGEYVDATNLTPRLWPRASAVGERLWSSKDVRDMDDAYDRLTRHRCRMVERGIAAQPLYAG--YCN 552
BLAST of Beta-hexosaminidase vs. UniProt/SwissProt
Match: sp|P49614|HEXB_FELCA (Beta-hexosaminidase subunit beta OS=Felis catus OX=9685 GN=HEXB PE=2 SV=2) HSP 1 Score: 468.774 bits (1205), Expect = 5.216e-159 Identity = 231/475 (48.63%), Postives = 318/475 (66.95%), Query Frame = 1
Query: 208 PQCNLLNDAIKRFTKYLYNSIYINYEGPINQSISKISISMVTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGEDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDG---KKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETMNGGGTYCN 1623
P C+LL +A +R+ +Y++ S ++ +VT D E L+P ESY + V + F+ + VWG+LR L+T Q+ Y+ S G +NE+ + D RF RG+++DT+RHFLPV++IL ++ M+ +K NV HWHIVDD+SFPYQS TFP+LS+KGS+ SHVYT DV ++++AR RGIRV+PEFDSPGH+ SWGKGQK+LLTPCY+ K SG+FGPI+P L+ TY FL++ FKEV +FPD +HLGGDEV F CW+SNP I F + GF DF +L+ +Y+ KL +V VKK ++VWQEVFD+ ++ TI+ VWK + + +E+ EVT + + +LS+ WYL++ISYG DW YY DP +FDG +K LVIGGEAC+WGE+VDATN+ R WPRAS V ERLWS + +T + + NRL RCR+V G +AE + G YC+
Sbjct: 63 PTCSLLQEAFRRYHEYIFGFDKRQRRPAKPNSAIELQQLLVTVVLDSE-CDLFPNITSDESYTLLVKEPVAFLKANRVWGVLRGLETFSQLIYQDSYGTFTVNESDIIDSPRFPHRGILIDTARHFLPVKSILKTLDAMAFNKFNVLHWHIVDDQSFPYQSVTFPELSNKGSY-SLSHVYTPNDVHTVIEYARLRGIRVIPEFDSPGHTQSWGKGQKDLLTPCYNEHKQSGTFGPINPILNSTYNFLSQFFKEVSMVFPDHFVHLGGDEVEFQCWESNPEIQGFMKQKGFGKDFRRLESFYLQKLLGIVS--TVKK---GSIVWQEVFDDHVKLLPG-TIVQVWKNQ-VYTEELREVTAAGFPVILSAPWYLDWISYGQDWRNYYKVDPLHFDGSQEQKKLVIGGEACLWGEFVDATNLTPRLWPRASAVGERLWSPEDITSVGNAYNRLTVHRCRMVRRGISAEPLFTG--YCD 526
BLAST of Beta-hexosaminidase vs. UniProt/SwissProt
Match: sp|Q6AXR4|HEXB_RAT (Beta-hexosaminidase subunit beta OS=Rattus norvegicus OX=10116 GN=Hexb PE=2 SV=1) HSP 1 Score: 467.233 bits (1201), Expect = 2.337e-158 Identity = 230/489 (47.03%), Postives = 319/489 (65.24%), Query Frame = 1
Query: 181 ENIKIQNPY-----PQCNLLNDAIKRFTKYLYNSIYINYEGPINQSISKISISMVTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGEDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDG---KKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETMNGGGTYCN 1623
EN +I N P C+LL +A +R+ Y++ Y + GP ++ + +P+ + ESY + V + + + EVWG LR L+T Q+ Y+ + G INE+ + D RF RG+++DTSRH+LPV+TI ++ M+ +K NV HWHIVDD+SFPYQS TFP+LS+KGS+ SHVYT D+ +L++AR RGIRV+PEFDSPGH+ SWGKGQKNLLTPC+ + GP+DP+L+ TY F + FKE+ +FPD +HLGGDEV F CW SNP I NF K GF N+F +L+ +Y+ K+ +++ L KK ++VWQ+VFD++ E+ Q T++ VWK E+ + E+A+VT S + A+LS+ WYL+ ISYG DW YY +P NF+G +K LVIGGEAC+WGEYVDATN+I R WPRAS V ERLWS + +T+L + RL RCR+V G A+ + G YCN
Sbjct: 53 ENFQIDNSPNSTAGPSCSLLLEAFRRYYNYIFG-FYKRHHGPAKFQDKPQLEKLLVFINLEPQCDAFPSMSSDESYSLLVQEPVALLKANEVWGALRGLETFSQLVYQDAYGTFTINESTIADSPRFPHRGILIDTSRHYLPVKTIFKTLDAMAFNKFNVLHWHIVDDQSFPYQSITFPELSNKGSYS-LSHVYTPNDIHMVLEYARLRGIRVIPEFDSPGHTQSWGKGQKNLLTPCFIQKIRTQKVGPVDPSLNTTYVFFDTFFKEISRVFPDQFIHLGGDEVEFECWASNPNIQNFMKKKGFGNNFRRLESFYIKKILDIITSL---KKS--SIVWQDVFDDQVEL-QPGTVVEVWKSEN-YLNELAQVTASGFPAILSAPWYLDLISYGQDWRNYYKAEPLNFEGSEKQKQLVIGGEACLWGEYVDATNLIPRLWPRASAVGERLWSPRIITNLENAYRRLAVHRCRMVSRGIAAQPLFTG--YCN 530
BLAST of Beta-hexosaminidase vs. UniProt/SwissProt
Match: sp|Q0V8R6|HEXA_BOVIN (Beta-hexosaminidase subunit alpha OS=Bos taurus OX=9913 GN=HEXA PE=2 SV=1) HSP 1 Score: 464.922 bits (1195), Expect = 1.148e-157 Identity = 224/479 (46.76%), Postives = 323/479 (67.43%), Query Frame = 1
Query: 214 CNLLNDAIKRFTKYLYNSIYINYEGPINQSISKISISMVTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGE--DKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDG---KKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETMNGGGTYCNIPGE 1635
C++L++A +R+ L+ S+ + PI + + S+V +P+ +E+Y + + + ++S+ VWG LR L+T Q+ +R G +N+T + D RF RGL+LDTSRH+LP+ +ILD +++M+ +K NVFHWH+VDD SFPY+S TFP+L+ KGS++ +H+YT +DV ++++AR RGIRV+ EFD+PGH+LSWG G LLTPCYSGS PSG+FGP++P L+ TY F++ F E+ +FPD LHLGGDEV+F CWKSNP I F K GF +DF KL+ +Y+ L ++V K + +VWQEVFDNK +V TII VW+ E K+ +E+A VT++ + A+LS+ WYLN+I+YG DW + Y +P F+G +K LVIGGEACMWGEYVD+TN++ R WPRA VAERLWSN+ V++L+ RL FRC L+ G A+ ++ G YC++ E
Sbjct: 58 CSVLDEAFQRYRDLLFGSVAFRFPHPIEKRHTSEKNSLVVLVVT-PGCDQFPSLGSVENYTLTINDEQSLLLSETVWGALRGLETFSQLIWRSPEGTFYVNKTDIEDFPRFPHRGLLLDTSRHYLPLASILDTLDVMAYNKFNVFHWHLVDDSSFPYESFTFPELTKKGSYNPATHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGPGVPGLLTPCYSGSHPSGTFGPVNPALNNTYEFMSTFFLEISTVFPDFYLHLGGDEVDFTCWKSNPDIQAFMKKKGFGDDFKKLESFYIQTLLDIVSAYG---KGY--VVWQEVFDNKVKVRPD-TIIQVWREEIPVKYVKELALVTRAGFRALLSAPWYLNHITYGPDWKEIYLVEPLAFEGSPEQKALVIGGEACMWGEYVDSTNLVPRLWPRAGAVAERLWSNKMVSNLDFAFKRLAHFRCELLRRGVQAQPLSVG--YCDMEFE 527
BLAST of Beta-hexosaminidase vs. TrEMBL
Match: H3AAJ1 (Beta-hexosaminidase OS=Latimeria chalumnae OX=7897 GN=HEXB PE=3 SV=1) HSP 1 Score: 501.901 bits (1291), Expect = 2.993e-169 Identity = 242/510 (47.45%), Postives = 348/510 (68.24%), Query Frame = 1
Query: 127 PLPKPFYIYSGGNV------FNLVENIKIQNPYPQCNLLNDAIKRFTKYLYNSIYINY--EGPINQSISKISISMVTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGEDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDG---KKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETMNGGGTYCN 1623
PLP+ +SG V F +V + + P C +L DA +R+ +Y++ N+ EG +N + ++ +D E K +P+ E+YQ+ V++ G + +++VWG LR L+T Q+ Y G IN + + D RF RG++LDTSRH++PV+ IL N++ M+ +K NVFHWHIVDD SFPYQS T+PDLS+KG++H +HVYT DV R++ FAR RGIRV+PEFD+PGH+ SWG GQK+LLTPCY+G+KPSG++GP++P L+ TY F+ KLFKE+ +FPD +HLGGDEVNF+CW+SNP + F ++G D+ KL+ +Y+ +L ++V L K + M+WQEVFDNK ++ + T++ VW +++E+ +VT + +TA+LS+ WYL+YISYG DW KYY +P F+G +K LVIGGEAC+WGEYVDATN+ R WPRAS VAERLWS+++VT++ D +RLH+ RCR+V G AE + G YC+
Sbjct: 49 PLPQSV-KFSGAEVQLSRSRFQIVHSAG-SSAGPSCFILQDAFRRYYEYIFGFSKWNHQAEGFLNNGAELTELQVLITSSDPECDK-YPSIKSNEAYQLSVSQSGAVLKAEKVWGALRGLETFSQLVYENGYGTYLINASEIKDFPRFSHRGVLLDTSRHYVPVKVILANLDAMAFNKFNVFHWHIVDDPSFPYQSTTYPDLSNKGAYHPATHVYTATDVHRVIQFARSRGIRVIPEFDTPGHTQSWGNGQKDLLTPCYNGAKPSGTYGPVNPILNSTYEFMGKLFKEISNVFPDEYVHLGGDEVNFHCWQSNPYVTKFMTEHGLGKDYRKLESFYIQRLLDIVSSL---NKGY--MIWQEVFDNKVKIKPE-TVVGVWIA-STYREELKKVTSAGFTAILSAPWYLDYISYGQDWQKYYRVEPLAFNGTDAQKRLVIGGEACLWGEYVDATNLTPRLWPRASAVAERLWSSETVTNIGDAYSRLHKHRCRMVRRGIPAEPLFIG--YCD 546
BLAST of Beta-hexosaminidase vs. TrEMBL
Match: H2VDU0 (Beta-hexosaminidase OS=Takifugu rubripes OX=31033 GN=hexb PE=3 SV=1) HSP 1 Score: 501.516 bits (1290), Expect = 4.241e-169 Identity = 254/506 (50.20%), Postives = 340/506 (67.19%), Query Frame = 1
Query: 127 PLPKPFYIYS-----GGNVFNLVENIKIQNPYPQCNLLNDAIKRFTKYLYNSIYINYE------GPINQSISKISISMVTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKG-EDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNF---DGKKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETM 1599
PLP+ I G FN+V+ K + P C LL DA +R+ +Y++ + + + GP + + ++ I+ + D + +P+ ESY++ V + + + +VWG L L+T Q+ Y GA IN T + D RF RG++LDTSRHFLPV+ IL N+E M+++K+NVFHWHIVD+ SFPY SKTFP LS +G+FH ++HVYT DV +++FAR RGIRVV EFD+PGH+ SWGKGQK+LLTPCYSGSK SGSFGP++P L+ TYTF+ + FKEV +FPD +HLGGDEV+FNCWKSNP I F + GF D++KL+ +Y+ +L ++V A K + MVWQEVFDN ++ TII+VWKG ++++Q EMA VT S Y +LS+ WYLN ISYG DW +Y DPQ+F D +K LVIGGEAC+WGEYVD+TNV R WPRAS VAERLWS++ V D+ND NRL RCR+V G AE +
Sbjct: 48 PLPQKVQISQVSFKLTGFSFNIVD-AKQSSAGPSCALLQDAYRRYYEYMFGNAKRSGKNKSRRTGPTDLTELQVWIT-----SADSDCDAYPSVKSDESYELTVDQPFAVLKAPKVWGALHGLETFSQLIYEDDYGAKSINATSISDFPRFPHRGILLDTSRHFLPVKVILANLETMAMNKINVFHWHIVDEPSFPYMSKTFPQLSQQGAFHPYTHVYTPADVKMVIEFARLRGIRVVAEFDTPGHTQSWGKGQKDLLTPCYSGSKLSGSFGPVNPILNTTYTFMTQFFKEVSTVFPDGYVHLGGDEVDFNCWKSNPNITKFMDQQGFGRDYSKLESFYIQRLLDIV---ATTNKGY--MVWQEVFDNGVKLKPD-TIIHVWKGNQEQYQNEMANVTASGYQTLLSTPWYLNRISYGQDWQGHYKADPQDFKGTDAQKKLVIGGEACLWGEYVDSTNVTPRLWPRASAVAERLWSSKDVRDVNDAYNRLSGHRCRMVERGIPAEPL 541
BLAST of Beta-hexosaminidase vs. TrEMBL
Match: A0A3Q3G324 (Beta-hexosaminidase OS=Labrus bergylta OX=56723 PE=3 SV=1) HSP 1 Score: 501.516 bits (1290), Expect = 4.786e-169 Identity = 238/472 (50.42%), Postives = 329/472 (69.70%), Query Frame = 1
Query: 208 PQCNLLNDAIKRFTKYLYNSIYINYEGPINQ----SISKISISMVTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGED-KWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDG---KKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETM 1599
P C+LL DA +R+ +Y++ S + +N+ S+++ V + D + +P+ ESY++ V + + + +VWG LR L+T Q+ + GA +N T + D RF RG++LDTSRH+LP++ IL N+E M+++K+NVFHWHIVDD+SFPY S+TFP LS +G++H ++HVYT DV +++FAR RGIRV+PEFD+PGH+ SWGKGQK+LLTPCYSG+ PSG+FGP++P L+ TY F+++ FKE+ +FPD +HLGGDEV+FNCWKSNP I F + GF DF+KL+ +Y+ +L N+V KK + M+WQEVFDN ++ TII+VWKG ++Q EMA VT + Y +LS+ WYLN ISYG DW +Y DPQ+F+G +K LV+GGEAC+WGEYVDATN+ R WPRAS VAERLWS + VTD+ND NRL RCR+V G AE +
Sbjct: 79 PSCSLLKDAYRRYYEYMFGS---SKRQQLNKRRRTGPSELTELQVLITSPDSDCDGYPSVTSDESYELSVDQPYAVLRAPKVWGALRGLETFSQLVFEDDYGAKSVNATQISDFPRFAHRGILLDTSRHYLPIKVILANLETMAMNKINVFHWHIVDDQSFPYLSRTFPQLSQQGAYHPYTHVYTPADVKMVIEFARLRGIRVIPEFDTPGHTQSWGKGQKDLLTPCYSGATPSGTFGPVNPILNTTYDFMSQFFKEISTVFPDAYVHLGGDEVDFNCWKSNPDIQKFMAQQGFGQDFSKLESFYIQRLLNIVTS---TKKGY--MIWQEVFDNGVKLKPD-TIIHVWKGTQLQYQNEMANVTSAGYQTLLSTPWYLNRISYGQDWRGHYKADPQDFNGTDEQKKLVVGGEACLWGEYVDATNLTPRLWPRASAVAERLWSAKDVTDINDAFNRLSVHRCRMVERGIPAEPL 541
BLAST of Beta-hexosaminidase vs. TrEMBL
Match: G3PTM9 (Beta-hexosaminidase OS=Gasterosteus aculeatus OX=69293 PE=3 SV=1) HSP 1 Score: 499.975 bits (1286), Expect = 1.512e-168 Identity = 238/474 (50.21%), Postives = 325/474 (68.57%), Query Frame = 1
Query: 214 CNLLNDAIKRFTKYLYNSIYINYEGPINQSISKISISM-VTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKG-EDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDG---KKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETMNGGGTYC 1620
C+LL +A +R+ +Y++ + + ++ + + V + D + +P ESY++ V + + + +VWG LR L+T Q+ Y GA IN T + D RF RG++LDTSRHFLP++ IL N+E M+++K NVFHWHIVDD+SFPY S+TFP +S +G++H ++HVYT DV +++F R RGIRVVPEFD+PGH+ SWGKGQK+LLTPCYSG KPSGSFGP++P L+ TY F++K FKE+ +FPD +HLGGDEV+FNCWKSNP I F + GF DF+KL+ +Y+ KL ++V A +K + M+WQEVFDN ++ + II+VWKG ++++Q EMA VT S + +LS+ WYLN ISYG DW +Y DPQ+F G +K LVIGGEAC+WGEYVDATN+ R WPRAS V ERLWS VTD+ND +RL RCR+V G AE + +YC
Sbjct: 81 CSLLQNAYRRYYEYIFGGSRVQHGAEGRRAGPSVLTELQVLIVSADSECERFPAVTSDESYELTVDQPYAVLKAPKVWGALRGLETFSQLVYEDEYGAKSINSTTISDFPRFAHRGILLDTSRHFLPIKVILANLEAMAMNKFNVFHWHIVDDQSFPYMSRTFPHISQQGAYHPYTHVYTPADVKMVIEFGRLRGIRVVPEFDTPGHTQSWGKGQKDLLTPCYSGDKPSGSFGPVNPILNTTYDFMSKFFKEISGVFPDAYVHLGGDEVDFNCWKSNPDIQKFMEQQGFGQDFSKLESFYIQKLLDIV---ATTQKGY--MIWQEVFDNGVKLKADM-IIHVWKGNQEQYQSEMANVTSSGFQTLLSTPWYLNRISYGQDWQGHYKADPQDFKGTEAQKKLVIGGEACLWGEYVDATNLTPRLWPRASAVGERLWSAVDVTDINDAFSRLSVHRCRMVERGIPAEPLF--SSYC 546
BLAST of Beta-hexosaminidase vs. TrEMBL
Match: A0A3B5AMC6 (Beta-hexosaminidase OS=Stegastes partitus OX=144197 PE=3 SV=1) HSP 1 Score: 500.36 bits (1287), Expect = 4.039e-168 Identity = 246/511 (48.14%), Postives = 339/511 (66.34%), Query Frame = 1
Query: 133 PKPFYIYSGGNVFNL----VENIKIQNPYPQCNLLNDAIKRFTKYLYNS------IYINYEGPINQSISKISISMVTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKG-EDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDG---KKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETMNGGGTYCN 1623
P P + S + F L + + K + P CN+L +A +R+ +Y++ + + GP + + ++ I+ + D +P+ ESY++ V + + + +VWG L L+T Q+ Y GA +N T++ D RF+ RG++LDTSRHFLP++ IL N+E M+++K NVFHWHIVDD+SFPY S+TFP LS +GS+H ++HVYT DV +++FAR RGIRVVPEFD+PGH+ SWGKGQ +LLTPCYSG KPSG+FGP++P L+ TY F+ + FKE+ +FPD +HLGGDEV+F CWKSNP I F GF D++KL+ +Y+ KL ++V KK + M+WQEVFDN ++ TII+VWKG + ++Q EMA VT S Y +LS+ WYLN ISYG DW+ +Y DPQ+F G +K LVIGGEAC+WGEYVDATN+ R WPRAS V ERLWS++ VTD+ND NRL RCR+V G AE + +YC
Sbjct: 84 PLPQKLKSTQDAFKLTSFRIVDAKDSSAGPSCNILQNAYRRYYEYMFGAGQKQGVFKLRRSGPSDLTGLQVWIT-----SADSECDGYPSVKSDESYELSVIQPFAVLKAPKVWGALHGLETFSQLVYEDEYGAKSVNATIITDFPRFKHRGILLDTSRHFLPIKVILANLETMAMNKFNVFHWHIVDDQSFPYLSRTFPQLSQQGSYHPYTHVYTPADVKMVIEFARLRGIRVVPEFDTPGHTQSWGKGQPDLLTPCYSGPKPSGAFGPVNPILNTTYDFMTQFFKEISTVFPDGYVHLGGDEVDFTCWKSNPDIQRFMDAQGFGQDYSKLESFYIQKLLDIV---TTTKKGY--MIWQEVFDNGVKLKPD-TIIHVWKGNQQQYQSEMANVTSSGYQTLLSTPWYLNRISYGQDWNVFYKADPQDFKGTEKQKALVIGGEACLWGEYVDATNLTPRLWPRASAVGERLWSSKDVTDINDAFNRLSAHRCRMVERGIPAEPLF--SSYCQ 581
BLAST of Beta-hexosaminidase vs. Ensembl Cavefish
Match: hexb (hexosaminidase B (beta polypeptide) [Source:ZFIN;Acc:ZDB-GENE-030131-2333]) HSP 1 Score: 482.256 bits (1240), Expect = 1.975e-164 Identity = 241/503 (47.91%), Postives = 326/503 (64.81%), Query Frame = 1
Query: 127 PLPKPFYIYSGGNVFNL------VENIKIQNPYPQCNLLNDAIKRFTKYLYNSIYINYEGPINQSI--SKISISMVTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSD-KGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGEDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDG---KKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETM 1599
PLP+ I G F L + + P C+LL +A +R+ Y++ + +G Q + S++ V D +P ESYQ+EV + + + VWG LR L+T Q+ Y GA IN+T + D RF RG++LDTSRH+LP++ IL N+E M+++K NVFHWHIVDD SFP+ S+TFPDLS KG+FH ++HVYT DV +++FAR RGIRVV EFD+PGH+ SWGKGQ +LLTPC+SGS P+G+FGP++P L+ TY F+ + FKEV +FPD +HLGGDEV+F+CWKSNP I F + GF D+ KL+ YY+ +L ++V + K + MVWQEVFDN ++ T ++VWK ++Q EMA +T + + +LSS WYLN ISYG DW Y DPQNF+G +K LVIGGEAC+WGEYVD TN+ R WPRAS V ERLWS+++V D+N NRL + RCR+V G AE +
Sbjct: 86 PLPQKIQI--SGAAFQLSSAGFQITHANGSTAGPSCSLLQNAFRRYFDYIFGNA--RKQGKNQQKVFDSELQELQVLLTAKDPECDGYPNLKTDESYQLEVDQPTSVLKAANVWGALRGLETFSQLVYEDDYGAHKINKTSISDFPRFAHRGILLDTSRHYLPLKAILTNLEAMAMNKFNVFHWHIVDDHSFPFLSRTFPDLSQRKGAFHPYTHVYTPSDVKMVIEFARMRGIRVVAEFDTPGHTQSWGKGQPDLLTPCFSGSSPTGTFGPVNPILNSTYDFMTRFFKEVSTVFPDAYIHLGGDEVDFSCWKSNPDIQKFMDQQGFGQDYKKLESYYIQRLLDIV---SATNKGY--MVWQEVFDNGVKLKAD-TQLHVWKENPQYQDEMARITAAGFYTLLSSPWYLNRISYGQDWQAVYKADPQNFNGTAEQKKLVIGGEACLWGEYVDGTNLTPRLWPRASAVGERLWSDENVKDINSAYNRLAKHRCRMVQRGIPAEPL 578
BLAST of Beta-hexosaminidase vs. Ensembl Cavefish
Match: hexb (hexosaminidase B (beta polypeptide) [Source:ZFIN;Acc:ZDB-GENE-030131-2333]) HSP 1 Score: 473.396 bits (1217), Expect = 3.405e-161 Identity = 238/503 (47.32%), Postives = 325/503 (64.61%), Query Frame = 1
Query: 127 PLPKPFYIYSGGNVFNL------VENIKIQNPYPQCNLLNDAIKRFTKYLYNSIYINYEGPINQSI--SKISISMVTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSD-KGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGEDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDG---KKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETM 1599
PLP+ I G F L + + P C+LL +A +R+ Y++ + +G Q + S++ V D +P ESYQ+EV + + + VWG LR L+T Q+ Y GA IN+T + D RF RG++LDTSRH+LP++ IL N+E M+++K NVFHWHIVDD SFP+ S+TFPDLS KG+FH ++HVYT DV +++FAR RGIRVV EFD+PGH+ SWGKGQ +LLTPC+SGS P+G+FGP++P L+ TY F+ + FKEV +FPD +HLGGDEV+F+CWKSNP I F + GF D+ KL+ YY+ +L ++V + K + MVWQEVFDN ++ T++ VW + E+ +VT S +T +LS+ WYL+YISYG DW KYY +P +F G +K LVIGGEAC+WGEYVD TN+ R WPRAS V ERLWS+++V D+N NRL + RCR+V G AE +
Sbjct: 68 PLPQKIQI--SGAAFQLSSAGFQITHANGSTAGPSCSLLQNAFRRYFDYIFGNA--RKQGKNQQKVFDSELQELQVLLTAKDPECDGYPNLKTDESYQLEVDQPTSVLKAANVWGALRGLETFSQLVYEDDYGAHKINKTSISDFPRFAHRGILLDTSRHYLPLKAILTNLEAMAMNKFNVFHWHIVDDHSFPFLSRTFPDLSQRKGAFHPYTHVYTPSDVKMVIEFARMRGIRVVAEFDTPGHTQSWGKGQPDLLTPCFSGSSPTGTFGPVNPILNSTYDFMTRFFKEVSTVFPDAYIHLGGDEVDFSCWKSNPDIQKFMDQQGFGQDYKKLESYYIQRLLDIV---SATNKGY--MVWQEVFDNGVKLKGD-TVVEVWMNNNV-DGELQKVTGSGFTTILSAPWYLDYISYGQDWQKYYKVEPLSFQGTAEQKKLVIGGEACLWGEYVDGTNLTPRLWPRASAVGERLWSDENVKDINSAYNRLAKHRCRMVQRGIPAEPL 559
BLAST of Beta-hexosaminidase vs. Ensembl Cavefish
Match: hexb (hexosaminidase B (beta polypeptide) [Source:ZFIN;Acc:ZDB-GENE-030131-2333]) HSP 1 Score: 473.011 bits (1216), Expect = 8.253e-161 Identity = 238/503 (47.32%), Postives = 325/503 (64.61%), Query Frame = 1
Query: 127 PLPKPFYIYSGGNVFNL------VENIKIQNPYPQCNLLNDAIKRFTKYLYNSIYINYEGPINQSI--SKISISMVTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSD-KGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGEDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDG---KKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETM 1599
PLP+ I G F L + + P C+LL +A +R+ Y++ + +G Q + S++ V D +P ESYQ+EV + + + VWG LR L+T Q+ Y GA IN+T + D RF RG++LDTSRH+LP++ IL N+E M+++K NVFHWHIVDD SFP+ S+TFPDLS KG+FH ++HVYT DV +++FAR RGIRVV EFD+PGH+ SWGKGQ +LLTPC+SGS P+G+FGP++P L+ TY F+ + FKEV +FPD +HLGGDEV+F+CWKSNP I F + GF D+ KL+ YY+ +L ++V + K + MVWQEVFDN ++ T++ VW + E+ +VT S +T +LS+ WYL+YISYG DW KYY +P +F G +K LVIGGEAC+WGEYVD TN+ R WPRAS V ERLWS+++V D+N NRL + RCR+V G AE +
Sbjct: 86 PLPQKIQI--SGAAFQLSSAGFQITHANGSTAGPSCSLLQNAFRRYFDYIFGNA--RKQGKNQQKVFDSELQELQVLLTAKDPECDGYPNLKTDESYQLEVDQPTSVLKAANVWGALRGLETFSQLVYEDDYGAHKINKTSISDFPRFAHRGILLDTSRHYLPLKAILTNLEAMAMNKFNVFHWHIVDDHSFPFLSRTFPDLSQRKGAFHPYTHVYTPSDVKMVIEFARMRGIRVVAEFDTPGHTQSWGKGQPDLLTPCFSGSSPTGTFGPVNPILNSTYDFMTRFFKEVSTVFPDAYIHLGGDEVDFSCWKSNPDIQKFMDQQGFGQDYKKLESYYIQRLLDIV---SATNKGY--MVWQEVFDNGVKLKGD-TVVEVWMNNNV-DGELQKVTGSGFTTILSAPWYLDYISYGQDWQKYYKVEPLSFQGTAEQKKLVIGGEACLWGEYVDGTNLTPRLWPRASAVGERLWSDENVKDINSAYNRLAKHRCRMVQRGIPAEPL 577
BLAST of Beta-hexosaminidase vs. Ensembl Cavefish
Match: hexa (beta-hexosaminidase subunit alpha-like [Source:NCBI gene;Acc:103046771]) HSP 1 Score: 460.685 bits (1184), Expect = 7.794e-157 Identity = 226/477 (47.38%), Postives = 309/477 (64.78%), Query Frame = 1
Query: 214 CNLLNDAIKRFTKYLYNSIYINYEGP---INQSISKISISMVTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKG-EDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDG---KKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMA-NRLHEFRCRLVINGFNAETMNGGGTYC 1620
C++L+ A KR+ ++ ++ + +S+S+ + D +P E ESY + V + ++ VWG LR L++ Q+ Y+ +N+T + D RF+FRGL+LDTSRH+LP+ IL ++ M+ SK NVFHWHIVDD SFPYQS ++PDLS KG+FH +H+YTQ DV R++ AR RGIRV+PEFD+PGH+ SWGKGQ NLLTPCY G PSG+FGP++P LD TY F++ LFKE+ +FPD+ +HLGGDEVNF CWKSNP + F K GF +D+ KL+ YY+ + N+ L + +VWQ+VFD + + K T++ +WKG ++ E+A++T + Y +LS+ WY+N+ISYG DW YT PQNF G +K LVIGGE CMWGEYVDATN+ R WPRA AERLWSN+ +T D A RL +FRC L+ G AE + G YC
Sbjct: 63 CSVLDSAFKRYYSLIFPDAADGARFSNIWMDPTPFTVSVSVKSGECDG-----YPDEGSDESYNLSVAAGAAALKAQSVWGALRGLESFSQLVYQDKYNMYFVNKTEIQDFPRFEFRGLLLDTSRHYLPLNAILKTLDAMAYSKFNVFHWHIVDDPSFPYQSYSYPDLSSKGAFHPMTHIYTQSDVKRVISHARMRGIRVIPEFDTPGHTQSWGKGQPNLLTPCYKGDVPSGTFGPVNPILDSTYQFMSGLFKEMKSVFPDSYVHLGGDEVNFACWKSNPNVRAFMTKMGFGHDYTKLESYYIENIVNISSAL-----NKTPIVWQDVFDYRERI-PKDTVLEIWKGVPADYRTELAKITHAGYRVLLSAPWYINHISYGQDWRNSYTVQPQNFSGTDQQKALVIGGEVCMWGEYVDATNLHPRLWPRACAAAERLWSNEEMTSNVDQAFPRLEKFRCSLIRRGIQAEPLFVG--YC 526
BLAST of Beta-hexosaminidase vs. Ensembl Cavefish
Match: hexb (hexosaminidase B (beta polypeptide) [Source:ZFIN;Acc:ZDB-GENE-030131-2333]) HSP 1 Score: 428.328 bits (1100), Expect = 7.649e-144 Identity = 221/502 (44.02%), Postives = 299/502 (59.56%), Query Frame = 1
Query: 127 PLPKPFYIYSGGNVFNL------VENIKIQNPYPQCNLLNDAIKRFTKYLYNSIYINYEGPINQSI--SKISISMVTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGEDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDG---KKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETM 1599
PLP+ I G F L + + P C+LL +A +R+ Y++ + +G Q + S++ V D +P ESYQ+EV + + + VWG LR L+T Q+ Y GA E M+++K NVFHWHIVDD SFP+ S+TFPDLS +G+FH ++HVYT DV +++FAR RGIRVV EFD+PGH+ SWGKGQ +LLTPC+SGS P+G+FGP++P L+ TY F+ + FKEV +FPD +HLGGDEV+F+CWKSNP I F + GF D+ KL+ YY+ +L ++V + K + MVWQEVFDN ++ T ++VWK ++Q EMA +T + + +LSS WYLN ISYG DW Y DPQNF+G +K LVIGGEAC+WGEYVD TN+ R WPRAS V ERLWS+++V D+N NRL + RCR+V G AE +
Sbjct: 86 PLPQKIQI--SGAAFQLSSAGFQITHANGSTAGPSCSLLQNAFRRYFDYIFGNA--RKQGKNQQKVFDSELQELQVLLTAKDPECDGYPNLKTDESYQLEVDQPTSVLKAANVWGALRGLETFSQLVYEDDYGA-------------------------------------EAMAMNKFNVFHWHIVDDHSFPFLSRTFPDLSQRGAFHPYTHVYTPSDVKMVIEFARMRGIRVVAEFDTPGHTQSWGKGQPDLLTPCFSGSSPTGTFGPVNPILNSTYDFMTRFFKEVSTVFPDAYIHLGGDEVDFSCWKSNPDIQKFMDQQGFGQDYKKLESYYIQRLLDIV---SATNKGY--MVWQEVFDNGVKLKAD-TQLHVWKENPQYQDEMARITAAGFYTLLSSPWYLNRISYGQDWQAVYKADPQNFNGTAEQKKLVIGGEACLWGEYVDGTNLTPRLWPRASAVGERLWSDENVKDINSAYNRLAKHRCRMVQRGIPAEPL 540
BLAST of Beta-hexosaminidase vs. Ensembl Sea Lamprey
Match: hexa (hexosaminidase A (alpha polypeptide) [Source:ZFIN;Acc:ZDB-GENE-050417-283]) HSP 1 Score: 445.277 bits (1144), Expect = 6.291e-152 Identity = 221/487 (45.38%), Postives = 329/487 (67.56%), Query Frame = 1
Query: 214 CNLLNDAIKRFTKYLYN-SIYINYEGPINQ-------SISKISISMVTNCTDDENTKLWPTENMIE--SYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGA--LCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWK-GEDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDG---KKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETMNGGGTYCNI 1626
C +L+DA +R+ +++ S Y +++ ++ ++S+ V + + +P + + ++ V + + VWG LR L+T Q+AYR + + +N+T + D RF+ RGL+LDTSRH+LP+ IL+ ++ M+ +KLNVFHWHIVDD+SFPYQS+TFP+LS+KG+++ +YT+ DV ++ +AR RGIRV+PEFD+PGH+ SWGKG+ NLLTPCY+G +PSG FGP+ P + TY F+ KLF E+ FPD +HLGGDEV+F+CW+SNP I +F K F D+ KL+ YY+ ++ ++V A KK + MVWQEVFDN ++ T+++VWK + ++QEMA+VT + ++ +LS+ WY+N I+YG DW KYY +P +F G +K+LV+GGEAC+WGEYVD TN+ R WPRAS VAERLWS++SVTD+ND +RL + RCR+V G A+ + G +C+I
Sbjct: 24 CQVLDDAFRRYYNIIFSGSPYPGASSKLHRKPTTKTRAVGEVSLLSVLVQSSHNDCNDFPGLKCLSVLTDELSVQAGESLLQAPSVWGALRGLETFSQLAYRDDNDGNKILMNKTEVVDFPRFRHRGLLLDTSRHYLPLIVILETLDAMAYNKLNVFHWHIVDDQSFPYQSQTFPELSEKGAYNPSRAIYTETDVGAVIWYARERGIRVIPEFDTPGHTQSWGKGEPNLLTPCYNGKEPSGLFGPVHPVTNSTYDFMKKLFNEISNAFPDHYIHLGGDEVSFSCWQSNPDITSFMEKMSFGKDYKKLESYYIQQILDIV---ASYKKGY--MVWQEVFDNGVKLKPD-TVVHVWKFMAEHYKQEMADVTAAGFSTLLSAPWYINSIAYGQDWTKYYAVEPLDFHGTDKQKELVVGGEACLWGEYVDGTNLTPRLWPRASAVAERLWSDKSVTDVNDAYSRLAKHRCRMV-RGIAAQPLFVG--FCDI 501
BLAST of Beta-hexosaminidase vs. Ensembl Nematostella
Match: EDO49845 (Beta-hexosaminidase [Source:UniProtKB/TrEMBL;Acc:A7RET7]) HSP 1 Score: 409.838 bits (1052), Expect = 2.526e-137 Identity = 202/408 (49.51%), Postives = 267/408 (65.44%), Query Frame = 1
Query: 385 ESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSG-SKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGEDKWQQEMAEVTKS-NYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDG---KKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAE 1593
ESY + VT I + VWG LR L+T Q+ ++ G + D RF R M+DTSRH+L + I ++ MS +K NV HWH+VDD+SFP+QS+TFP LSD+GSF+ +HVY+ DV I+D+AR RGIRV+PEFD+PGH+ SW + NLLT C KP+GS GPIDPT+D Y FL F EV + FPD +HLGGDEV F CW+SNP I + K F +++KL+ YY KL N++ GL + ++WQEV DN +V T++NVWKG W E+A+VT + A+LSS WYLNYISYGIDW YY +P +F+G +K+LVIGG CMWGE+VD TN+++RTWPRA +AERLWS++S TD+ R+ E RCR ++ G AE
Sbjct: 130 ESYTLTVTAPQSSIYAYTVWGALRGLETFSQIVHQSEDGMYYAKGNKIEDYPRFHHRAFMIDTSRHYLKLSIIKKFLDAMSYAKFNVLHWHVVDDQSFPFQSQTFPSLSDQGSFNNKTHVYSPADVADIIDYARMRGIRVIPEFDTPGHTYSW-RSIPNLLTKCCDAKGKPTGSLGPIDPTIDSNYDFLKAFFGEVAKRFPDQYIHLGGDEVGFGCWQSNPNITAWMEKMRFGTNYSKLEEYYETKLLNIIGGLGK-----QYIIWQEVVDNDVKVLPD-TVVNVWKG--GWPAELAKVTGAKKLKAILSSPWYLNYISYGIDWPNYYKVEPTDFEGTDQEKELVIGGTGCMWGEFVDGTNILARTWPRALAIAERLWSSKSTTDMTSAYARIWEHRCRYLLRGIPAE 528
BLAST of Beta-hexosaminidase vs. Ensembl Nematostella
Match: EDO26761 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7TB56]) HSP 1 Score: 216.853 bits (551), Expect = 1.505e-65 Identity = 122/349 (34.96%), Postives = 189/349 (54.15%), Query Frame = 1
Query: 520 TVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTP---CYSGSKPSGSFGP-IDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGEDKWQQE--MAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDP----QNFDGKKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDM 1536
T + D RF +RGL++D +RHF PV I N+E ++ K+NVFHWH+ DD+ F +SK +P L + S + YTQ + ++ +A R GIRV+PE D PGH+ + L + Y+ + +G F P ++PT+D+TY FL LF EV +FPD H+GGDE W N ++ F K+ + LQ Y+ IKL ++ K M W E+ KN +I+ W+G + +E + E K Y +VLS+ +Y++ + + +Y DP + ++ V+GGEA MWGE V + SR WPR + +AER WS +++TD++ +
Sbjct: 1 TKISDTPRFLWRGLLIDAARHFQPVDVIKRNLEALAAVKMNVFHWHLTDDQGFRIESKVYPKLHELASDGLY---YTQHQIKDVVKYAARLGIRVIPEIDVPGHATAILTAYPELGSKDKYTYTLQRNAGIFDPTLNPTIDKTYEFLENLFAEVTSLFPDEYFHIGGDENEGKHWSENKKMTAFKKKHNLKTNH-DLQTYFNIKLEKILSKFGK-----KLMGWDEIM-TKNM--PTTAVIHSWRGTTEGLKESTLIEAAKKGYQSVLSNGYYIDRMQSVV---HHYKVDPIGNAKLTPAQRARVLGGEATMWGELVTPLTIDSRIWPRTAAIAERFWSPKNITDIDHL 334
BLAST of Beta-hexosaminidase vs. Ensembl Nematostella
Match: EDO29436 (Beta-hexosaminidase [Source:UniProtKB/TrEMBL;Acc:A7T3N0]) HSP 1 Score: 127.487 bits (319), Expect = 2.315e-31 Identity = 132/519 (25.43%), Postives = 217/519 (41.81%), Query Frame = 1
Query: 127 PLPKPFYIYSGGNVFNLVENIKIQNPYPQCNLLNDAIKRFTKYLYNSIYINYEGPINQSISKISISMVTNCTDDENTKLWPTENMIESYQMEVTKDG---IFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLS-WGKGQKNLLTPCYSG-----SKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGEDKWQQEMAEVTKSNYTAV--LSSCWYLNYISYGIDWHKYYTCDPQNFDGKK-DLVIGGEACMWGE---YV---------------------DAT---NVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCR 1566
PLP+ G +L I+ + + +L I R+ + + ++ +N S ++ + ++ +DDE+ N SY+ ++ D + + +G L ++T Q+ + G+L + D+ F RGLMLDT R F P+ + + ++ MS KLNV H+H+ D F +SK FPDL + S +YTQ DV ++ +AR RGIRV+PE + H+ G K L +SG + P G+ T + + E++ +FP+ + HLG DEV FT KN LQ + + +L+Q + W+E + V + T+I WK E + + A+ LSS +YLNY+ G+ + +T + + ++GGE MW + Y+ D T +V WPRA V A W+ S D++ EF R
Sbjct: 36 PLPRELEASGGPLPLSLAFTIQTSS---ESEILARGITRYLEIITTHLHTAARSRVNGS-KELEVLRISVKSDDESL------NEGTSYEYSLSFDSGPQATLTALTPYGALYGMETFSQL---VVDGSLVYTSVSISDKPSFVHRGLMLDTGRRFFPMDLLYNTLDAMSYVKLNVLHFHLSDLCRFSVESKLFPDLRNNE-----SEIYTQDDVRNLVAYARDRGIRVMPEVEGAAHANGLLGLKNKGLQFCNHSGYTQLYNDPQGN----------TLKTMKAILSEMVPLFPEQIFHLGLDEV-------------FTDKN---CTLQSLQSFELALQEHLLQLGKIPA------AWEEALSSTKSVTNR-TVIQAWKAEG-----IKTIVDLKQFAINSLSSHFYLNYM--GVTPLQLWTDIAVGLNETEVQYLLGGEMAMWTDNYCYILECAYPLSAKPSAYWMYDPLHDGTFTQSVAGIIWPRAVVGAGSFWNYNS-----DLSADSAEFNMR 491
BLAST of Beta-hexosaminidase vs. Ensembl Nematostella
Match: EDO46502 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RQ54]) HSP 1 Score: 107.842 bits (268), Expect = 1.774e-24 Identity = 107/483 (22.15%), Postives = 188/483 (38.92%), Query Frame = 1
Query: 376 NMIESYQMEVTKD-GIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFH---------------------RFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSW-----------------GKGQKNLLT----PCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPD----TLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFA----KLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFD--NKNEVDQKLTIINVWKGEDKWQQEMAEVTKSNYTAVLSSCWYLNY--------ISYGIDWHKYYT-------------------------------------CDPQNFDGKKDLVIGGEACMWGEYV-DATNVISRTWPRASVVAERLWSNQSVTDL 1527
N +E+Y+++V +D + I+ K G+ +QTL + I + + + D R+++RG+ LD R+F +T+ ++ M+ KLN FH+H+ +DE + + +L+ GS + Y+ D IL++A +R I V+PE D P HS + K QK LLT P S + I+P ++ TYTF+ + KE++ + + H GGDEV W ++ NF + G A KL+ Y++ ++ N+ + ++ ++ + F ++ + W+G Q + + Y +LS +L + G W +T C P N K + ++G +W E V A + S +PR +AER W S D+
Sbjct: 29 NSLEAYKLDVNEDPSVVIIGKGNAGVFYGIQTLLGI---IDTNNSIPSILTIRDSPRYEYRGMHLDVGRNFKTKETVKRLLDAMATYKLNKFHFHLTEDEGWRLEIPGLEELTSVGSKRCHDLKEQECLLPQLGSDPNGSKVKQFYSVLDYKEILEYAEKRHIEVIPEIDMPAHSRAAIKAMEARYQRFKKIGDDNKAQKYLLTEPGDPSRYISVQWFTDNAINPCMESTYTFVKHVVKEIVRMHQHFQKLKMFHFGGDEVAHGAWTNSTACKNFARRLGLKFSSADIVDKLKEYFVQRVANITKDESLDLGGWEDGMLGPKFVPYDRESIKSSQVFAYAWRGGG---QRAYNLANAGYKVILSQATHLYFDHPYEPEPEERGYYWAARFTDTRKTFGYLPEDLYANVKVTKWGEPLDRTALCKEPNSCPPLN---KTENILGMTGALWTETVRTADQMDSMVFPRLLALAERAWHKASWEDV 502
BLAST of Beta-hexosaminidase vs. Ensembl Nematostella
Match: EDO42823 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S0E8]) HSP 1 Score: 101.679 bits (252), Expect = 1.866e-22 Identity = 112/516 (21.71%), Postives = 193/516 (37.40%), Query Frame = 1
Query: 289 PINQSISKISISMVTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRF---------------------SHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSF---------------------GPIDPTLDQTYTFLNKLFKEV----IEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGF----PNDFAKLQGYYMIKLTNLV--QGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGEDKW--QQEMAEVTKSNYTAVLSSCWYLNY--------ISYGIDWHKYYTCDPQNF----------------------------DG------KKDLVIGGEACMWGEYV-DATNVISRTWPRASVVAERLWSNQSVTDLNDMANR 1545
P NQS ++ D N + S +++V + I + G+ +QTL +A + ++ + + D R+ +RG+ LD R+F+ +L ++ M+ K+N FH+H+ DDE + + +L+ GS + + Y+ D IL A I+V+PEFD PGH + K + S PS + I+P ++ TY F+ K+ EV +I P T+ H GGDEV W + + G+ + KL+GY++ ++ N+ GL++ + + EV N+ + W +W + + + Y V++ +L + G W +T + F +G KK+ +IG +W E V A + S +PR VAER W S D++D R
Sbjct: 225 PFNQS------KLIRLVKGDPNVTRGVASSEAYSLEIKVAEKEIKLTGSHASGVFYGVQTLIALADKENTVPMV----TIKDAPRYGYRGMHLDVGRNFMEKAAVLKLLDAMATYKMNKFHFHLTDDEGWRLEIPGLEELTTVGSKRCYDINTTRCILSQLGSGPSPSTSAQYYSVSDYKEILKRANDLHIQVIPEFDMPGHGYAAIKSMEARFKRL-KDSNPSEASKYILSDFNDTSKYLSIQYFTDNAINPCIESTYAFIEKVLTEVKSMHKDIQPLTVYHFGGDEVAHGAWTKSSACEQLAQRMGYNLTGSDIVDKLKGYFVERVANITVNDGLSLAGWEDGLLGHGEVPYNRKSFRNSNVMAYAWNNIWEWGSGKRAYLLANAGYKVVMTQATHLYFDFPYEPDPQERGYYWATRFTDTRKTFGFMPDNLFNNVEQKVTGEPLTREELCKTEGMCVELVKKENIIGMAGALWTETVRTADQMDSMIFPRLLAVAERAWHKASWEDISDKTER 729
BLAST of Beta-hexosaminidase vs. Ensembl Medaka
Match: hexb (hexosaminidase subunit beta [Source:NCBI gene;Acc:101158618]) HSP 1 Score: 491.886 bits (1265), Expect = 7.868e-169 Identity = 243/508 (47.83%), Postives = 331/508 (65.16%), Query Frame = 1
Query: 127 PLPKPFYIYS-----GGNVFNLVENIKIQNPYPQCNLLNDAIKRFTKYLYNSIYINYEGPINQSISK--------ISISMVTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKG-EDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDG---KKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETM 1599
PLP+ I G F + K P C+LL A +R+ Y++ GP Q +S+ ++ V+ + D +P+ ESY++ V + + VWG L L+T Q+ Y GA IN T + D RF RG++LD+SRHFLP++ +L N+E M+++K NVFHWHIVDD+SFPY S+TFP LS +G++H +SHVYT DV +++FAR RGIRV+PEFD+PGH+ SWGKGQ +LLTPC+SG+ PSGSFGP++P L+ TY F+++ FKEV ++FPD +HLGGDEV+F CWKSNP I F + GF D++KL+ +Y+ KL ++V KK + ++WQEVFDN ++ T+I+VWKG ++++Q EMA++T + Y +LSS WYLN ISYG DW Y DPQ+F G +K LVIGGEAC+WGEYVDATN+ R WPRAS VAERLWS + VTD+ND NRL RCR+V G AE +
Sbjct: 44 PLPQKVQISEVPLKLSGATFEFT-DAKGSTAGPSCSLLQSAYRRYYDYIFG-------GPKKQKMSRNRRAGPLELTELQVSITSPDSQCDGYPSVTSDESYELSVDVPVAVLKAPTVWGALHGLETFSQLVYEDDYGAKTINSTKVSDFPRFAHRGILLDSSRHFLPIKVLLANLETMAMNKFNVFHWHIVDDQSFPYLSRTFPQLSQQGAYHPYSHVYTPSDVKMVIEFARLRGIRVIPEFDTPGHTQSWGKGQMDLLTPCFSGATPSGSFGPVNPILNTTYDFMSRFFKEVSDVFPDGYVHLGGDEVDFTCWKSNPDIKKFMDRQGFGQDYSKLESFYIQKLLDIV---TTTKKGY--IIWQEVFDNGVKLKPD-TLIHVWKGNQEQYQNEMAKITSAGYQTLLSSPWYLNRISYGQDWQSTYKADPQDFKGTEEQKKLVIGGEACLWGEYVDATNLTPRLWPRASAVAERLWSAKDVTDINDAYNRLSAHRCRMVERGIPAEPL 537
BLAST of Beta-hexosaminidase vs. Ensembl Medaka
Match: hexb (hexosaminidase subunit beta [Source:NCBI gene;Acc:101158618]) HSP 1 Score: 485.337 bits (1248), Expect = 2.985e-166 Identity = 240/507 (47.34%), Postives = 327/507 (64.50%), Query Frame = 1
Query: 127 PLPKPFYIYS-----GGNVFNLVENIKIQNPYPQCNLLNDAIKRFTKYLYNSIYINYEGPINQSISK--------ISISMVTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGEDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDG---KKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETM 1599
PLP+ I G F + K P C+LL A +R+ Y++ GP Q +S+ ++ V+ + D +P+ ESY++ V + + VWG L L+T Q+ Y GA IN T + D RF RG++LD+SRHFLP++ +L N+E M+++K NVFHWHIVDD+SFPY S+TFP LS +G++H +SHVYT DV +++FAR RGIRV+PEFD+PGH+ SWGKGQ +LLTPC+SG+ PSGSFGP++P L+ TY F+++ FKEV ++FPD +HLGGDEV+F CWKSNP I F + GF D++KL+ +Y+ KL ++V KK + ++WQEVFDN ++ T+++VW G EM +VT + YT +LS+ WYL+YISY DW KYY +P NF+G +K LVIGGEAC+WGEYVDATN+ R WPRAS VAERLWS + VTD+ND NRL RCR+V G AE +
Sbjct: 44 PLPQKVQISEVPLKLSGATFEFT-DAKGSTAGPSCSLLQSAYRRYYDYIFG-------GPKKQKMSRNRRAGPLELTELQVSITSPDSQCDGYPSVTSDESYELSVDVPVAVLKAPTVWGALHGLETFSQLVYEDDYGAKTINSTKVSDFPRFAHRGILLDSSRHFLPIKVLLANLETMAMNKFNVFHWHIVDDQSFPYLSRTFPQLSQQGAYHPYSHVYTPSDVKMVIEFARLRGIRVIPEFDTPGHTQSWGKGQMDLLTPCFSGATPSGSFGPVNPILNTTYDFMSRFFKEVSDVFPDGYVHLGGDEVDFTCWKSNPDIKKFMDRQGFGQDYSKLESFYIQKLLDIV---TTTKKGY--IIWQEVFDNGVKLKPD-TVVHVWMGSGS-DAEMNKVTTAGYTTILSAPWYLDYISYAQDWQKYYKVEPLNFNGTEEQKKLVIGGEACLWGEYVDATNLTPRLWPRASAVAERLWSAKDVTDINDAYNRLSAHRCRMVERGIPAEPL 535
BLAST of Beta-hexosaminidase vs. Ensembl Medaka
Match: hexa (beta-hexosaminidase subunit alpha [Source:NCBI gene;Acc:101172329]) HSP 1 Score: 438.343 bits (1126), Expect = 2.583e-147 Identity = 215/458 (46.94%), Postives = 300/458 (65.50%), Query Frame = 1
Query: 214 CNLLNDAIKRFTKYLYNSIYINYEGPINQSIS-KISISMVTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGEDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDG---KKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMA-NRLHEFRCRLV 1572
C+LL+ A +R+ ++ Y G + + + S+ + T+ D EN +P ++ E Y + V+ + + VWGILR L+T Q+ Y+ G+ +NET + D RFQFRG++LDTSRH+LPV IL ++ MS SK NVFHWHIVDD SFPYQS++FP+LS KG+FH +H+YTQ DV R++ +AR RGIRV+PEFDSPGH+ SWGKGQ +LLTPCY G PSG+FGP++P L TY F+ FKEV +FPD+ +HLGGDEV+F+CW+SNP + F K GF DF KL+ +Y+ + N+ + ++VWQ+VFD +E L+++ VWK + ++ +VTK+ +L+S WYL+ +W +YYT P F G +K LVIGGE CMWGEYVDATN+ + WPRAS AERLWS++ T + A RL +FRC+L+
Sbjct: 70 CSLLDAAFRRYFLLIFPD-YTAENGQLEVAANNSFSLYISTDHNDCEN---YPNDDSSERYNLSVSAGQASLNAATVWGILRGLETFSQLVYQDDLGSYFVNETFIEDFPRFQFRGVLLDTSRHYLPVHAILKTLDAMSYSKFNVFHWHIVDDPSFPYQSRSFPELSKKGAFHPATHIYTQSDVRRVISYARMRGIRVLPEFDSPGHTGSWGKGQSHLLTPCYKGGAPSGTFGPVNPALQSTYQFMASFFKEVTSVFPDSYIHLGGDEVDFSCWRSNPHVRAFMQKMGFGGDFPKLEAFYIENIVNITSA-----NNKTSIVWQDVFD-YHERRSALSVVEVWK-HGCYLCKVRQVTKAGLRVILASPWYLDLPGPTHNWARYYTVWPLAFPGSEKQKRLVIGGEVCMWGEYVDATNLFPKLWPRASAAAERLWSDEKQTSSVEKAFPRLEDFRCKLL 516
BLAST of Beta-hexosaminidase vs. Planmine SMEST
Match: SMESG000037355.1 (SMESG000037355.1) HSP 1 Score: 1090.49 bits (2819), Expect = 0.000e+0 Identity = 522/522 (100.00%), Postives = 522/522 (100.00%), Query Frame = 1
Query: 73 MLRYFIGVCILLYVNAYDPLPKPFYIYSGGNVFNLVENIKIQNPYPQCNLLNDAIKRFTKYLYNSIYINYEGPINQSISKISISMVTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGEDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDGKKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETMNGGGTYCNIPGEI 1638
MLRYFIGVCILLYVNAYDPLPKPFYIYSGGNVFNLVENIKIQNPYPQCNLLNDAIKRFTKYLYNSIYINYEGPINQSISKISISMVTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGEDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDGKKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETMNGGGTYCNIPGEI
Sbjct: 1 MLRYFIGVCILLYVNAYDPLPKPFYIYSGGNVFNLVENIKIQNPYPQCNLLNDAIKRFTKYLYNSIYINYEGPINQSISKISISMVTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYSGSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNGFPNDFAKLQGYYMIKLTNLVQGLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGEDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDGKKDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETMNGGGTYCNIPGEI 522
BLAST of Beta-hexosaminidase vs. Planmine SMEST
Match: SMESG000002681.1 (SMESG000002681.1) HSP 1 Score: 344.354 bits (882), Expect = 6.625e-109 Identity = 177/448 (39.51%), Postives = 259/448 (57.81%), Query Frame = 1
Query: 328 VTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYS-GSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNG-FPNDFAKLQGYYMIKLTNLVQ--GLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGEDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDGK----------------KDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETMNGGG 1611
+ N + ++ WP+ M E+YQ+ V+ GIFI +KE WG LR L++L QM +R +G + INET + DQ RF+ RG+MLDT+RHF+P I+ N++ M ++K+NVFHWH+ DD+SFP ++ + + G++ VY + V I+++AR RGIRV+PE DSP H+LSW K ++T C K SG +GP++ TY L L+K++I +FPD +HLG DEV +C SN I ++ G F D L +Y KL N++ GL+ K +VWQE ++ +N V +K TI+ +WK + E A + K N + S+CWYL+ + YG W +Y CDP + G ++ ++GGEA MW E++DA NVI R WP AS AERLWS + + A+RL E RCR+ A +G G
Sbjct: 234 IVNIYVESDSHQWPSLYMNETYQISVSLKGIFISAKETWGALRGLESLSQMMWRTRAGRIFINETKVQDQPRFKHRGVMLDTARHFIPKDIIMKNLDAMVMNKMNVFHWHLTDDQSFPLITENHAEFALHGAYDPEHKVYRPEVVKEIIEYARVRGIRVIPEIDSPSHTLSWRKSHPEVMTRCIDMNGKWSGHYGPVNMAAASTYRLLTSLYKDIINLFPDQWIHLGSDEVATSCLSSNQAIQSWMRSRGMFSVD--SLIDFYTRKLQNIITQLGLSNNNKQRGFIVWQEAYE-RNSVLKKGTIVQLWKSQST--AEAATLAKQNIQVIYSACWYLDRLEYGAQWLNHYQCDPGDEYGNQMVMNDYVNVPVNDNWRENILGGEAAMWLEFLDADNVIPRIWPLASAAAERLWSPNFINNAEKAASRLEEMRCRMFSRSIPAGVASGAG 676
BLAST of Beta-hexosaminidase vs. Planmine SMEST
Match: SMESG000002681.1 (SMESG000002681.1) HSP 1 Score: 343.969 bits (881), Expect = 6.627e-109 Identity = 177/448 (39.51%), Postives = 259/448 (57.81%), Query Frame = 1
Query: 328 VTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYS-GSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNG-FPNDFAKLQGYYMIKLTNLVQ--GLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGEDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDGK----------------KDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETMNGGG 1611
+ N + ++ WP+ M E+YQ+ V+ GIFI +KE WG LR L++L QM +R +G + INET + DQ RF+ RG+MLDT+RHF+P I+ N++ M ++K+NVFHWH+ DD+SFP ++ + + G++ VY + V I+++AR RGIRV+PE DSP H+LSW K ++T C K SG +GP++ TY L L+K++I +FPD +HLG DEV +C SN I ++ G F D L +Y KL N++ GL+ K +VWQE ++ +N V +K TI+ +WK + E A + K N + S+CWYL+ + YG W +Y CDP + G ++ ++GGEA MW E++DA NVI R WP AS AERLWS + + A+RL E RCR+ A +G G
Sbjct: 218 IVNIYVESDSHQWPSLYMNETYQISVSLKGIFISAKETWGALRGLESLSQMMWRTRAGRIFINETKVQDQPRFKHRGVMLDTARHFIPKDIIMKNLDAMVMNKMNVFHWHLTDDQSFPLITENHAEFALHGAYDPEHKVYRPEVVKEIIEYARVRGIRVIPEIDSPSHTLSWRKSHPEVMTRCIDMNGKWSGHYGPVNMAAASTYRLLTSLYKDIINLFPDQWIHLGSDEVATSCLSSNQAIQSWMRSRGMFSVD--SLIDFYTRKLQNIITQLGLSNNNKQRGFIVWQEAYE-RNSVLKKGTIVQLWKSQST--AEAATLAKQNIQVIYSACWYLDRLEYGAQWLNHYQCDPGDEYGNQMVMNDYVNVPVNDNWRENILGGEAAMWLEFLDADNVIPRIWPLASAAAERLWSPNFINNAEKAASRLEEMRCRMFSRSIPAGVASGAG 660
BLAST of Beta-hexosaminidase vs. Planmine SMEST
Match: SMESG000002681.1 (SMESG000002681.1) HSP 1 Score: 343.969 bits (881), Expect = 7.026e-109 Identity = 177/448 (39.51%), Postives = 259/448 (57.81%), Query Frame = 1
Query: 328 VTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYS-GSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNG-FPNDFAKLQGYYMIKLTNLVQ--GLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGEDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDGK----------------KDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETMNGGG 1611
+ N + ++ WP+ M E+YQ+ V+ GIFI +KE WG LR L++L QM +R +G + INET + DQ RF+ RG+MLDT+RHF+P I+ N++ M ++K+NVFHWH+ DD+SFP ++ + + G++ VY + V I+++AR RGIRV+PE DSP H+LSW K ++T C K SG +GP++ TY L L+K++I +FPD +HLG DEV +C SN I ++ G F D L +Y KL N++ GL+ K +VWQE ++ +N V +K TI+ +WK + E A + K N + S+CWYL+ + YG W +Y CDP + G ++ ++GGEA MW E++DA NVI R WP AS AERLWS + + A+RL E RCR+ A +G G
Sbjct: 220 IVNIYVESDSHQWPSLYMNETYQISVSLKGIFISAKETWGALRGLESLSQMMWRTRAGRIFINETKVQDQPRFKHRGVMLDTARHFIPKDIIMKNLDAMVMNKMNVFHWHLTDDQSFPLITENHAEFALHGAYDPEHKVYRPEVVKEIIEYARVRGIRVIPEIDSPSHTLSWRKSHPEVMTRCIDMNGKWSGHYGPVNMAAASTYRLLTSLYKDIINLFPDQWIHLGSDEVATSCLSSNQAIQSWMRSRGMFSVD--SLIDFYTRKLQNIITQLGLSNNNKQRGFIVWQEAYE-RNSVLKKGTIVQLWKSQST--AEAATLAKQNIQVIYSACWYLDRLEYGAQWLNHYQCDPGDEYGNQMVMNDYVNVPVNDNWRENILGGEAAMWLEFLDADNVIPRIWPLASAAAERLWSPNFINNAEKAASRLEEMRCRMFSRSIPAGVASGAG 662
BLAST of Beta-hexosaminidase vs. Planmine SMEST
Match: SMESG000002681.1 (SMESG000002681.1) HSP 1 Score: 344.354 bits (882), Expect = 8.062e-109 Identity = 177/448 (39.51%), Postives = 259/448 (57.81%), Query Frame = 1
Query: 328 VTNCTDDENTKLWPTENMIESYQMEVTKDGIFIMSKEVWGILRALQTLFQMAYRISSGALCINETVLYDQARFQFRGLMLDTSRHFLPVQTILDNIELMSISKLNVFHWHIVDDESFPYQSKTFPDLSDKGSFHRFSHVYTQKDVLRILDFARRRGIRVVPEFDSPGHSLSWGKGQKNLLTPCYS-GSKPSGSFGPIDPTLDQTYTFLNKLFKEVIEIFPDTLLHLGGDEVNFNCWKSNPRIVNFTVKNG-FPNDFAKLQGYYMIKLTNLVQ--GLAVKKKDFKTMVWQEVFDNKNEVDQKLTIINVWKGEDKWQQEMAEVTKSNYTAVLSSCWYLNYISYGIDWHKYYTCDPQNFDGK----------------KDLVIGGEACMWGEYVDATNVISRTWPRASVVAERLWSNQSVTDLNDMANRLHEFRCRLVINGFNAETMNGGG 1611
+ N + ++ WP+ M E+YQ+ V+ GIFI +KE WG LR L++L QM +R +G + INET + DQ RF+ RG+MLDT+RHF+P I+ N++ M ++K+NVFHWH+ DD+SFP ++ + + G++ VY + V I+++AR RGIRV+PE DSP H+LSW K ++T C K SG +GP++ TY L L+K++I +FPD +HLG DEV +C SN I ++ G F D L +Y KL N++ GL+ K +VWQE ++ +N V +K TI+ +WK + E A + K N + S+CWYL+ + YG W +Y CDP + G ++ ++GGEA MW E++DA NVI R WP AS AERLWS + + A+RL E RCR+ A +G G
Sbjct: 232 IVNIYVESDSHQWPSLYMNETYQISVSLKGIFISAKETWGALRGLESLSQMMWRTRAGRIFINETKVQDQPRFKHRGVMLDTARHFIPKDIIMKNLDAMVMNKMNVFHWHLTDDQSFPLITENHAEFALHGAYDPEHKVYRPEVVKEIIEYARVRGIRVIPEIDSPSHTLSWRKSHPEVMTRCIDMNGKWSGHYGPVNMAAASTYRLLTSLYKDIINLFPDQWIHLGSDEVATSCLSSNQAIQSWMRSRGMFSVD--SLIDFYTRKLQNIITQLGLSNNNKQRGFIVWQEAYE-RNSVLKKGTIVQLWKSQST--AEAATLAKQNIQVIYSACWYLDRLEYGAQWLNHYQCDPGDEYGNQMVMNDYVNVPVNDNWRENILGGEAAMWLEFLDADNVIPRIWPLASAAAERLWSPNFINNAEKAASRLEEMRCRMFSRSIPAGVASGAG 674 The following BLAST results are available for this feature:
BLAST of Beta-hexosaminidase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Beta-hexosaminidase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 3
BLAST of Beta-hexosaminidase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Beta-hexosaminidase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Beta-hexosaminidase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Beta-hexosaminidase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 2
BLAST of Beta-hexosaminidase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Beta-hexosaminidase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Beta-hexosaminidase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Beta-hexosaminidase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 1
BLAST of Beta-hexosaminidase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Beta-hexosaminidase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Beta-hexosaminidase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 3
BLAST of Beta-hexosaminidase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30033380 ID=SMED30033380|Name=Beta-hexosaminidase|organism=Schmidtea mediterranea sexual|type=transcript|length=1762bpback to top protein sequence of SMED30033380-orf-1 >SMED30033380-orf-1 ID=SMED30033380-orf-1|Name=SMED30033380-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=523bp MLRYFIGVCILLYVNAYDPLPKPFYIYSGGNVFNLVENIKIQNPYPQCNLback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
|
