Leukotriene A-4 hydrolase

Query:  310 HFNWKLDFENEQISGSVVHNVKVLNSASKELILDVRNLEIKRIVIDNEDVLFQYVNGKL----GGKLVIPLSLGTKRSKFQVI-IEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSND---VRQHKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKM-LRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLNKFSRMLPDQRYYFFQVLND-----IQGVQLPESSLKVMGNIYGLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMHPIT 2064
            H    +DF    ++G+    V+      + L+LD ++L I+++VI+ ++V  +Y  G+     G  + I L +   +++  VI I + T+  S+ALQW+ PE T GK+H +L+SQ QAI+ R++ PCQDTP VK TY+A +  P +L  +MSA+R   T   +    + +KF QK+PIP YL+++  G L   +IGPR+ V+SE E  EK+  EF + E +L IAE+L GPY W   DLL+LPPSFPYGGMENPC+ F+TP LL GDKS  N IAHEISHSWTGNLVTN TWDHFW+NEGHT YLER I  +L   E +RH +   G  EL+  +      +G  H FTKLV +L   DPD ++S VPYEKG  LLFYLE L+G  ++ L +LK Y+  F  KS++TD+WK F + Y  +K  V    L  + W+ W Y PG  PI+ +   D ++   C  L + WI      +++ + LN F+    D +      LN+     +Q   LP   +K M  +Y      NSE+   W  LC++S +  A+    +    QGR+K+ + L+K L  +D +  + V  +   K +MHP+T
Sbjct:   23 HLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEV--KYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRL-FGEKFRHFNALGGWGELQNSVK----TFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDV----LNQVDWNAWLYSPGLPPIKPN--YDMTLTNACIALSQRWI------TAKEDDLNSFNAT--DLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVT 600          

Query:  403 ILDVRNLEIKRIVIDNEDVLFQYVNGKL----GGKLVIPLSLGTKRSKFQVI-IEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSND---VRQHKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKM-LRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLNKFSRMLPDQRYYFFQVLND-----IQGVQLPESSLKVMGNIYGLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMHPIT 2064
            +LD ++L I+++VI+ ++V  +Y  G+     G  + I L +   +++  VI I + T+  S+ALQW+ PE T GK+H +L+SQ QAI+ R++ PCQDTP VK TY+A +  P +L  +MSA+R   T   +    + +KF QK+PIP YL+++  G L   +IGPR+ V+SE E  EK+  EF + E +L IAE+L GPY W   DLL+LPPSFPYGGMENPC+ F+TP LL GDKS  N IAHEISHSWTGNLVTN TWDHFW+NEGHT YLER I  +L   E +RH +   G  EL+  +      +G  H FTKLV +L   DPD ++S VPYEKG  LLFYLE L+G  ++ L +LK Y+  F  KS++TD+WK F + Y  +K  V    L  + W+ W Y PG  PI+ +   D ++   C  L + WI      +++ + LN F+    D +      LN+     +Q   LP   +K M  +Y      NSE+   W  LC++S +  A+    +    QGR+K+ + L+K L  +D +  + V  +   K +MHP+T
Sbjct:   30 VLDTKDLTIEKVVINGQEV--KYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRL-FGEKFRHFNALGGWGELQNSVK----TFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDV----LNQVDWNAWLYSPGLPPIKPN--YDMTLTNACIALSQRWI------TAKEDDLNSFNAT--DLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVT 576          

Query:  403 ILDVRNLEIKRIVIDNEDVLFQYVNGKL----GGKLVIPLSLGTKRSKFQVI-IEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSND---VRQHKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKM-LRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLNKFS 1737
            +LD ++L I+++VI+ ++V  +Y  G+     G  + I L +   +++  VI I + T+  S+ALQW+ PE T GK+H +L+SQ QAI+ R++ PCQDTP VK TY+A +  P +L  +MSA+R   T   +    + +KF QK+PIP YL+++  G L   +IGPR+ V+SE E  EK+  EF + E +L IAE+L GPY W   DLL+LPPSFPYGGMENPC+ F+TP LL GDKS  N IAHEISHSWTGNLVTN TWDHFW+NEGHT YLER I  +L   E +RH +   G  EL+  +      +G  H FTKLV +L   DPD ++S VPYEKG  LLFYLE L+G  ++ L +LK Y+  F  KS++TD+WK F + Y  +K  V    L  + W+ W Y PG  PI+ +   D ++   C  L + WI      +++ + LN F+
Sbjct:   30 VLDTKDLTIEKVVINGQEV--KYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRL-FGEKFRHFNALGGWGELQNSVKT----FGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDV----LNQVDWNAWLYSPGLPPIKPN--YDMTLTNACIALSQRWI------TAKEDDLNSFN 464          

Query:  262 DKTSYANSEDFIVDKSHFNWKLDFE-------NEQISGSVVHNVKVLN-SASKELILD------VRNLEIKRIVIDNEDVLFQYVN------GKLGGKLVIPLSLGTKRS-KFQVIIEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSNDVRQHKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFED-IEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLH-GKDPDDSFSRVPYEKGSLLLFYLETLIG-KDKMLRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLNKFSRML---PDQRYYFFQVLNDI-QGVQLPESSLKVMGNIY-GLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDD-TKSRTVENFHIQKFAMHPITRGEIHKIIFPR 2097
            D  S +N   F +   H + + +F        +  +SG+ V +++ L    + EL LD      V    ++R    +E+   + V+         G  L +      + + + QV++ Y    +   + W+ PE T GKK  F+Y+Q QA+  R+ +PC DTP VK  YSA IE P     VMSA   S+       +  F+   PIPSYL+++A G LV +++GPRS V++EP L + A+ E+   IE+ L   E+L GPY W   DLL +PPSFP+GGMENPC+ F+TPCLL GD+S  + I HEISHSW GNLVTN+ W  FW+NEG T Y +R I   L  +  Y  L    G + L   ++    I G ++   KL   +  G DPDD+++  PYEKG   + YL  L+G +D+   +LK Y+  F+ +S+  D++  F+ +Y  E +K     + G ++D W   PG  P        DS+++   EL + W        +  EL  K    +   P + Y     L+ I Q   LP  ++K +G+ Y  ++N  N+EL   W  + L++ +     +V EFL++QG+ KY   LY  +    +  ++   E F      +H      + +I+ P+
Sbjct:   24 DVASASNFRAFELLHLHLDLRAEFGPPGPGAGSRGLSGTAVLDLRCLEPEGAAELRLDSHPCLEVTAAALRRERPGSEEPPAEPVSFYTQPFSHYGQALCVSFPQPCRAAERLQVLLTYRV-GEGPGVCWLAPEQTAGKKKPFVYTQGQAVLNRAFFPCFDTPAVKYKYSALIEVPDGFTAVMSA---STWEKRGPNKFFFQMCQPIPSYLIALAIGDLVSAEVGPRSRVWAEPCLIDAAKEEYNGVIEEFLATGEKLFGPYVWGRYDLLFMPPSFPFGGMENPCLTFVTPCLLAGDRSLADVIIHEISHSWFGNLVTNANWGEFWLNEGFTMYAQRRISTILFGAA-YTCLEAATGRALLRQHMD----ITGEENPLNKLRVKIEPGVDPDDTYNETPYEKGFCFVSYLAHLVGDQDQFDSFLKAYVHEFKFRSILADDFLDFYLEYFPELKKKRVDIIPGFEFDRWLNTPGWPPYLPDLSPGDSLMKPAEELAQLW--------AAEELDMKAIEAVAISPWKTYQLVYFLDKILQKSPLPPGNVKKLGDTYPSISNARNAELRLRWGQIVLKNDHQEDFWKVKEFLHNQGKQKYTLPLYHAMMGGSEVAQTLAKETFASTASQLHSNVVNYVQQIVAPK 648          

Query:  586 WMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSNDVRQHKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFED-IEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLH-GKDPDDSFSRVPYEKGSLLLFYLETLIG-KDKMLRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEK 1551
            W+ PE T GKK  F+Y+Q QA+  R+ +PC DTP VK  YSA IE P     VMSA   S+       +  F+   PIPSYL+++A G LV +++GPRS V++EP L + A+ E+   IE+ L   E+L GPY W   DLL +PPSFP+GGMENPC+ F+TPCLL GD+S  + I HEISHSW GNLVTN+ W  FW+NEG T Y +R I   L  +  Y  L    G + L   ++    I G ++   KL   +  G DPDD+++  PYEKG   + YL  L+G +D+   +LK Y+  F+ +S+  D++  F+ +Y  E +K
Sbjct:   21 WLAPEQTAGKKKPFVYTQGQAVLNRAFFPCFDTPAVKYKYSALIEVPDGFTAVMSA---STWEKRGPNKFFFQMCQPIPSYLIALAIGDLVSAEVGPRSRVWAEPCLIDAAKEEYNGVIEEFLATGEKLFGPYVWGRYDLLFMPPSFPFGGMENPCLTFVTPCLLAGDRSLADVIIHEISHSWFGNLVTNANWGEFWLNEGFTMYAQRRISTILFGAA-YTCLEAATGRALLRQHMD----ITGEENPLNKLRVKIEPGVDPDDTYNETPYEKGFCFVSYLAHLVGDQDQFDSFLKAYVHEFKFRSILADDFLDFYLEYFPELKK 337          

Query:  262 DKTSYANSEDFIVDKSHFNWKLDFENEQISGSVVHNVKVLNSASKELILDVRNLEIKRIVID--NEDVLFQYV---NGKLGGKLVIPLSLGTKRSKFQVIIEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSNDVRQ--HKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKD-KMLRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLNKFSRMLPDQRYYFFQVLNDIQGVQLPESSLKVMGNIYGLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMHPITRGEIHKII 2088
            D ++ AN E   V      WK+DFE + I+G V   + V    ++ ++LD R+L ++ + ++   E     +    N  LG KLVI         +  + I+Y ++N++ ALQ++  E T  +   +L+SQ QAINARS+ PC DTP VK+TY A +  P  L  +MSA+ + ST S   ++    F+Q + IPSYL++I  GHL   +I  R  V++EP   E +  EF + EKIL +AE++ GPY W   DL++LP +FP+GGMENPC+ F+TP LL GD+S +N IAHEISHSWTGNLVTN +W+HFW+NEG T +LER I  K+   E  R      G    E  +     ++GPDHE+TKLV NL   DPDD+FS VPYEKGS LLF +E  +G + +  ++L+ YI  +  K+VST+EWK + +    +K+ +    L+ I W+ W +K G  P   +   D + +Q C +L   W        ++ E+  K S           +V   + G ++P      +   Y L    N+EL   W +L L + + P VD    F  + GR+KY K +Y+ L+ W  T+ R +  F      MHPIT   I  ++
Sbjct:    8 DPSTAANYEQVTVSHYALKWKVDFEKKHIAGDVSITLDV-KQDTERIVLDTRDLSVQSVALNLNGEPKKAGFTLEDNQALGQKLVITTESLKSGDRPVLEIKYESSNNAAALQFLTAEQTTDRVAPYLFSQCQAINARSIVPCMDTPSVKSTYEAEVCVPIGLTCLMSAIGQGSTPSECGKRTIFSFKQPVSIPSYLLAIVVGHLERKEISERCAVWAEPSQAEASFYEFAETEKILKVAEDVAGPYVWGRYDLVVLPATFPFGGMENPCLTFITPTLLAGDRSLVNVIAHEISHSWTGNLVTNFSWEHFWLNEGFTVFLERKIHGKMY-GELERQFESESGYE--EALVRTVNDVFGPDHEYTKLVQNLGNADPDDAFSSVPYEKGSALLFTIEQALGDNSRFEQFLRDYIQKYAYKTVSTEEWKEYLYDSFTDKKVI----LDNIDWNLWLHKAGLPPKPKY---DSTPMQACKDLAAKWTTEGSEAPTDGEVFAKMSNSQKLAVLDAVRVNKTMFGDRMP-----ALTATYKLDQAKNAELKFSWLMLGLETKWSPIVDASLAFALAVGRMKYCKPIYRSLFGWSATRDRAISQFKANIPNMHPITVKAIQSLL 608          

Query:  262 DKTSYANSEDFIVDKSHFNWKLDFENEQISGSVVHNVKVLNSASKELILDVRNLEIKRIVID--NEDVLFQYV---NGKLGGKLVIPLSLGTKRSKFQVIIEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSNDVRQ--HKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKD-KMLRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLNKFSRMLPDQRYYFFQVLNDIQGVQLPESSLKVMGNIYGLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMHPITRGEIHKII 2088
            D ++ AN E   V      WK+DFE + I+G V   + V    ++ ++LD R+L ++ + ++   E     +    N  LG KLVI         +  + I+Y ++N++ ALQ++  E T  +   +L+SQ QAINARS+ PC DTP VK+TY A +  P  L  +MSA+ + ST S   ++    F+Q + IPSYL++I  GHL   +I  R  V++EP   E +  EF + EKIL +AE++ GPY W   DL++LP +FP+GGMENPC+ F+TP LL GD+S +N IAHEISHSWTGNLVTN +W+HFW+NEG T +LER I  K+   E  R      G    E  +     ++GPDHE+TKLV NL   DPDD+FS VPYEKGS LLF +E  +G + +  ++L+ YI  +  K+VST+EWK + +    +K+ +    L+ I W+ W +K G  P   +   D + +Q C +L   W        ++ E+  K S           +V   + G ++P      +   Y L    N+EL   W +L L + + P VD    F  + GR+KY K +Y+ L+ W  T+ R +  F      MHPIT   I  ++
Sbjct:    8 DPSTAANYEQVTVSHYALKWKVDFEKKHIAGDVSITLDV-KQDTERIVLDTRDLSVQSVALNLNGEPKKAGFTLEDNQALGQKLVITTESLKSGDRPVLEIKYESSNNAAALQFLTAEQTTDRVAPYLFSQCQAINARSIVPCMDTPSVKSTYEAEVCVPIGLTCLMSAIGQGSTPSECGKRTIFSFKQPVSIPSYLLAIVVGHLERKEISERCAVWAEPSQAEASFYEFAETEKILKVAEDVAGPYVWGRYDLVVLPATFPFGGMENPCLTFITPTLLAGDRSLVNVIAHEISHSWTGNLVTNFSWEHFWLNEGFTVFLERKIHGKMY-GELERQFESESGYE--EALVRTVNDVFGPDHEYTKLVQNLGNADPDDAFSSVPYEKGSALLFTIEQALGDNSRFEQFLRDYIQKYAYKTVSTEEWKEYLYDSFTDKKVI----LDNIDWNLWLHKAGLPPKPKY---DSTPMQACKDLAAKWTTEGSEAPTDGEVFAKMSNSQKLAVLDAVRVNKTMFGDRMP-----ALTATYKLDQAKNAELKFSWLMLGLETKWSPIVDASLAFALAVGRMKYCKPIYRSLFGWSATRDRAISQFKANIPNMHPITVKAIQSLL 608          

Query:  262 DKTSYANSEDFIVDKSHFNWKLDFENEQISGSVVHNVKVLNSASKELILDVRNLEIKRIVID--NEDVLFQYV---NGKLGGKLVIPLSLGTKRSKFQVIIEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSNDVRQ--HKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKD-KMLRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLNKFSRMLPDQRYYFFQVLNDIQGVQLPESSLKVMGNIYGLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMHPITRGEIHKII 2088
            D ++ AN E   V      WK+DFE + I+G V   + V    ++ ++LD R+L ++ + ++   E     +    N  LG KLVI         +  + I+Y ++N++ ALQ++  E T  +   +L+SQ QAINARS+ PC DTP VK+TY A +  P  L  +MSA+ + ST S   ++    F+Q + IPSYL++I  GHL   +I  R  V++EP   E +  EF + EKIL +AE++ GPY W   DL++LP +FP+GGMENPC+ F+TP LL GD+S +N IAHEISHSWTGNLVTN +W+HFW+NEG T +LER I  K+   E  R      G    E  +     ++GPDHE+TKLV NL   DPDD+FS VPYEKGS LLF +E  +G + +  ++L+ YI  +  K+VST+EWK + +    +K+ +    L+ I W+ W +K G  P   +   D + +Q C +L   W        ++ E+  K S           +V   + G ++P      +   Y L    N+EL   W +L L + + P VD    F  + GR+KY K +Y+ L+ W  T+ R +  F      MHPIT   I  ++
Sbjct:    8 DPSTAANYEQVTVSHYALKWKVDFEKKHIAGDVSITLDV-KQDTERIVLDTRDLSVQSVALNLNGEPKKAGFTLEDNQALGQKLVITTESLKSGDRPVLEIKYESSNNAAALQFLTAEQTTDRA-PYLFSQCQAINARSIVPCMDTPSVKSTYEAEVCVPIGLTCLMSAIGQGSTPSECGKRTIFSFKQPVSIPSYLLAIVVGHLERKEISERCAVWAEPSQAEASFYEFAETEKILKVAEDVAGPYVWGRYDLVVLPATFPFGGMENPCLTFITPTLLAGDRSLVNVIAHEISHSWTGNLVTNFSWEHFWLNEGFTVFLERKIHGKMY-GELERQFESESGYE--EALVRTVNDVFGPDHEYTKLVQNLGNADPDDAFSSVPYEKGSALLFTIEQALGDNSRFEQFLRDYIQKYAYKTVSTEEWKEYLYDSFTDKKVI----LDNIDWNLWLHKAGLPPKPKY---DSTPMQACKDLAAKWTTEGSEAPTDGEVFAKMSNSQKLAVLDAVRVNKTMFGDRMP-----ALTATYKLDQAKNAELKFSWLMLGLETKWSPIVDASLAFALAVGRMKYCKPIYRSLFGWSATRDRAISQFKANIPNMHPITVKAIQSLL 607          

Query:  262 DKTSYANSEDFIVDKSHFNWKLDFENEQISGSVVHNVKVLNSASKELILDVRNLEIKRIVID--NEDVLFQYV---NGKLGGKLVIPLSLGTKRSKFQVIIEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSNDVRQ--HKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKD-KMLRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLNKFSRMLPDQRYYFFQVLNDIQGVQLPESSLKVMGNIYGLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMHPITRGEIHKII 2088
            D ++ AN E   V      WK+DFE + I+G V   + V    ++ ++LD R+L ++ + ++   E     +    N  LG KLVI         +  + I+Y ++N++ ALQ++  E T  +   +L+SQ QAINARS+ PC DTP VK+TY A +  P  L  +MSA+ + ST S   ++    F+Q + IPSYL++I  GHL   +I  R  V++EP   E +  EF + EKIL +AE++ GPY W   DL++LP +FP+GGMENPC+ F+TP LL GD+S +N IAHEISHSWTGNLVTN +W+HFW+NEG T +LER I  K+   E  R      G    E  +     ++GPDHE+TKLV NL   DPDD+FS VPYEKGS LLF +E  +G + +  ++L+ YI  +  K+VST+EWK + +    +K+ +    L+ I W+ W +K G  P   +   D + +Q C +L   W        ++ E+  K S           +V   + G ++P      +   Y L    N+EL   W +L L + + P VD    F  + GR+KY K +Y+ L+ W  T+ R +  F      MHPIT   I  ++
Sbjct:    8 DPSTAANYEQVTVSHYALKWKVDFEKKHIAGDVSITLDV-KQDTERIVLDTRDLSVQSVALNLNGEPKKAGFTLEDNQALGQKLVITTESLKSGDRPVLEIKYESSNNAAALQFLTAEQTTDRA-PYLFSQCQAINARSIVPCMDTPSVKSTYEAEVCVPIGLTCLMSAIGQGSTPSECGKRTIFSFKQPVSIPSYLLAIVVGHLERKEISERCAVWAEPSQAEASFYEFAETEKILKVAEDVAGPYVWGRYDLVVLPATFPFGGMENPCLTFITPTLLAGDRSLVNVIAHEISHSWTGNLVTNFSWEHFWLNEGFTVFLERKIHGKMY-GELERQFESESGYE--EALVRTVNDVFGPDHEYTKLVQNLGNADPDDAFSSVPYEKGSALLFTIEQALGDNSRFEQFLRDYIQKYAYKTVSTEEWKEYLYDSFTDKKVI----LDNIDWNLWLHKAGLPPKPKY---DSTPMQACKDLAAKWTTEGSEAPTDGEVFAKMSNSQKLAVLDAVRVNKTMFGDRMP-----ALTATYKLDQAKNAELKFSWLMLGLETKWSPIVDASLAFALAVGRMKYCKPIYRSLFGWSATRDRAISQFKANIPNMHPITVKAIQSLL 607          

Query:  262 DKTSYANSEDFIVDKSHFNWKLDFENEQISGSVVHNVKVLNSASKELILDVRNLEIKRIVID--NEDVLFQYV---NGKLGGKLVIPLSLGTKRSKFQVIIEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSNDVRQ--HKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKD-KMLRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLNKFSRMLPDQRYYFFQVLNDIQGVQLPESSLKVMGNIYGLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMHPITRGEIHKII 2088
            D ++ AN E   V      WK+DFE + I+G V   + V    ++ ++LD R+L ++ + ++   E     +    N  LG KLVI         +  + I+Y ++N++ ALQ++  E T  +   +L+SQ QAINARS+ PC DTP VK+TY A +  P  L  +MSA+ + ST S   ++    F+Q + IPSYL++I  GHL   +I  R  V++EP   E +  EF + EKIL +AE++ GPY W   DL++LP +FP+GGMENPC+ F+TP LL GD+S +N IAHEISHSWTGNLVTN +W+HFW+NEG T +LER I  K+   E  R      G    E  +     ++GPDHE+TKLV NL   DPDD+FS VPYEKGS LLF +E  +G + +  ++L+ YI  +  K+VST+EWK + +    +K+ +    L+ I W+ W +K G  P   +   D + +Q C +L   W        ++ E+  K S           +V   + G ++P      +   Y L    N+EL   W +L L + + P VD    F  + GR+KY K +Y+ L+ W  T+ R +  F      MHPIT   I  ++
Sbjct:    8 DPSTAANYEQVTVSHYALKWKVDFEKKHIAGDVSITLDV-KQDTERIVLDTRDLSVQSVALNLNGEPKKAGFTLEDNQALGQKLVITTESLKSGDRPVLEIKYESSNNAAALQFLTAEQTTDRA-PYLFSQCQAINARSIVPCMDTPSVKSTYEAEVCVPIGLTCLMSAIGQGSTPSECGKRTIFSFKQPVSIPSYLLAIVVGHLERKEISERCAVWAEPSQAEASFYEFAETEKILKVAEDVAGPYVWGRYDLVVLPATFPFGGMENPCLTFITPTLLAGDRSLVNVIAHEISHSWTGNLVTNFSWEHFWLNEGFTVFLERKIHGKMY-GELERQFESESGYE--EALVRTVNDVFGPDHEYTKLVQNLGNADPDDAFSSVPYEKGSALLFTIEQALGDNSRFEQFLRDYIQKYAYKTVSTEEWKEYLYDSFTDKKVI----LDNIDWNLWLHKAGLPPKPKY---DSTPMQACKDLAAKWTTEGSEAPTDGEVFAKMSNSQKLAVLDAVRVNKTMFGDRMP-----ALTATYKLDQAKNAELKFSWLMLGLETKWSPIVDASLAFALAVGRMKYCKPIYRSLFGWSATRDRAISQFKANIPNMHPITVKAIQSLL 607          

Query:  262 DKTSYANSEDFIVDKSHFNWKLDFENEQISGSVVHNVKVLNSASKELILDVRNLEIKRIVI---DNEDVLFQYVNGK---LGGKLVIPLSLGTKRSKFQVIIEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSNDVRQHKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKMLR-WLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLN----KFSRMLPDQRYYFFQVLNDIQGVQLPESSLKVMGNIYGLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMHPITRGEIHK 2082
            D +SY+  +    + S  NWK+DF   +I GSV+H  KVL +   +++LDVR++ +    +    +E  +  +++     +G KL + L  GT +    V I+Y T++ ++ LQW+ P  T+GK+H +++SQ QAI+ARS+ PCQDTP VK TY AT+E PS+L  +MSA+        +  +  F+Q++PIP+YLV+IA G LV   +G  S+V++E  + +    EF +   +L  A ELCGPY W+  DLL++PPSFP+GGMENPC+ F+TP LL GDKS  + +AHEI+HSWTGNLVTN  ++HFW+NEG T ++E  I+ ++Q ++      +   +++L+  +   Q+   P  E TKLV +L    PDD+FS VPY KGS  L YLE L G   +   +L+ Y+  +  KS+ T ++++  + Y I+ +K +  KL  + WD W    G  P+  +   D+S+     EL   W        S  EL +    K +  +     +  +++     V L E  + ++ + Y L ++ N+E+    + L +R+  +  +D++ EF NS  R+K+ + +Y+ L  W + K   + NF   K  M  +    I K
Sbjct:    8 DPSSYSQPDLITTEHSALNWKIDFAATKIQGSVLHRFKVLTANLDKILLDVRDINVTNATLLAGGSELPINFFISDAVDDIGQKLTLELPSGTAKGSLNVRIDYETSSSASGLQWLNPTQTLGKEHPYMFSQCQAIHARSVIPCQDTPAVKFTYDATVEHPSELTALMSALIDK----KEPGKTLFKQEVPIPAYLVAIAIGKLVSRPLGENSSVWAEEAIVDACAEEFSETATMLKTATELCGPYVWKQYDLLVMPPSFPFGGMENPCLTFVTPTLLAGDKSLADVVAHEIAHSWTGNLVTNKNFEHFWLNEGFTVFVESKIVGRMQGAKEL-DFKMLSNLTDLQECIRT-QLNKTP--ELTKLVVDLSNCGPDDAFSSVPYIKGSTFLRYLEDLFGGPTVFEPFLRDYLKKYAYKSIETKDFQSALYDYFIDTDKKD--KLSAVDWDLWLKSEGMPPVIPN--FDESLANVTKELASLWSS-----KSVAELADSAEIKTTISIHQLIDFLGKLIESKDIVDLNEGKINLLESTYNLKSSKNAEVRFRLNRLIIRARLIKRLDEILEFANSNFRMKFCRPIYRDLAGWPEAKPAAIRNFVNVKDQMMAVCSHTIEK 608          

Query:  262 DKTSYANSEDFIVDKSHFNWKLDFENEQISGSVVHNVKVLNSASKELILDVRNLEIKRIVI---DNEDVLFQYVNGK---LGGKLVIPLSLGTKRSKFQVIIEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSNDVRQHKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKMLR-WLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLN----KFSRMLPDQRYYFFQVLNDIQGVQLPESSLKVMGNIYGLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMHPITRGEIHK 2082
            D +SY+  +    + S  NWK+DF   +I GSV+H  KVL +   +++LDVR++ +    +    +E  +  +++     +G KL + L  GT +    V I+Y T++ ++ LQW+ P  T+GK+H +++SQ QAI+ARS+ PCQDTP VK TY AT+E PS+L  +MSA+        +  +  F+Q++PIP+YLV+IA G LV   +G  S+V++E  + +    EF +   +L  A ELCGPY W+  DLL++PPSFP+GGMENPC+ F+TP LL GDKS  + +AHEI+HSWTGNLVTN  ++HFW+NEG T ++E  I+ ++Q ++      +   +++L+  +   Q+   P  E TKLV +L    PDD+FS VPY KGS  L YLE L G   +   +L+ Y+  +  KS+ T ++++  + Y I+ +K +  KL  + WD W    G  P+  +   D+S+     EL   W        S  EL +    K +  +     +  +++     V L E  + ++ + Y L ++ N+E+    + L +R+  +  +D++ EF NS  R+K+ + +Y+ L  W + K   + NF   K  M  +    I K
Sbjct:    8 DPSSYSQPDLITTEHSALNWKIDFAATKIQGSVLHRFKVLTANLDKILLDVRDINVTNATLLAGGSELPINFFISDAVDDIGQKLTLELPSGTAKGSLNVRIDYETSSSASGLQWLNPTQTLGKEHPYMFSQCQAIHARSVIPCQDTPAVKFTYDATVEHPSELTALMSALIDK----KEPGKTLFKQEVPIPAYLVAIAIGKLVSRPLGENSSVWAEEAIVDACAEEFSETATMLKTATELCGPYVWKQYDLLVMPPSFPFGGMENPCLTFVTPTLLAGDKSLADVVAHEIAHSWTGNLVTNKNFEHFWLNEGFTVFVESKIVGRMQGAKEL-DFKMLSNLTDLQECIRT-QLNKTP--ELTKLVVDLSNCGPDDAFSSVPYIKGSTFLRYLEDLFGGPTVFEPFLRDYLKKYAYKSIETKDFQSALYDYFIDTDKKD--KLSAVDWDLWLKSEGMPPVIPN--FDESLANVTKELASLWSS-----KSVAELADSAEIKTTISIHQLIDFLGKLIESKDIVDLNEGKINLLESTYNLKSSKNAEVRFRLNRLIIRARLIKRLDEILEFANSNFRMKFCRPIYRDLAGWPEAKPAAIRNFVNVKDQMMAVCSHTIEK 608          

Query:  262 DKTSYANSEDFIVDKSHFNWKLDFENEQISGSVVHNVKVLNSASKELILDVRNLEIKRIVI---DNEDVLFQYVNGK---LGGKLVIPLSLGTKRSKFQVIIEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSNDVRQHKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKMLR-WLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLN----KFSRMLPDQRYYFFQVLNDIQGVQLPESSLKVMGNIYGLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMHPITRGEIHK 2082
            D +SY+  +    + S  NWK+DF   +I GSV+H  KVL +   +++LDVR++ +    +    +E  +  +++     +G KL + L  GT +    V I+Y T++ ++ LQW+ P  T+GK+H +++SQ QAI+ARS+ PCQDTP VK TY AT+E PS+L  +MSA+         +    F+Q++PIP+YLV+IA G LV   +G  S+V++E  + +    EF +   +L  A ELCGPY W+  DLL++PPSFP+GGMENPC+ F+TP LL GDKS  + +AHEI+HSWTGNLVTN  ++HFW+NEG T ++E  I+ ++Q ++      +   +++L+  +   Q+   P  E TKLV +L    PDD+FS VPY KGS  L YLE L G   +   +L+ Y+  +  KS+ T ++++  + Y I+ +K +  KL  + WD W    G  P+  +   D+S+     EL   W        S  EL +    K +  +     +  +++     V L E  + ++ + Y L ++ N+E+    + L +R+  +  +D++ EF NS  R+K+ + +Y+ L  W + K   + NF   K  M  +    I K
Sbjct:   79 DPSSYSQPDLITTEHSALNWKIDFAATKIQGSVLHRFKVLTANLDKILLDVRDINVTNATLLAGGSELPINFFISDAVDDIGQKLTLELPSGTAKGSLNVRIDYETSSSASGLQWLNPTQTLGKEHPYMFSQCQAIHARSVIPCQDTPAVKFTYDATVEHPSELTALMSALIDKKEPGKTL----FKQEVPIPAYLVAIAIGKLVSRPLGENSSVWAEEAIVDACAEEFSETATMLKTATELCGPYVWKQYDLLVMPPSFPFGGMENPCLTFVTPTLLAGDKSLADVVAHEIAHSWTGNLVTNKNFEHFWLNEGFTVFVESKIVGRMQGAKEL-DFKMLSNLTDLQECIRT-QLNKTP--ELTKLVVDLSNCGPDDAFSSVPYIKGSTFLRYLEDLFGGPTVFEPFLRDYLKKYAYKSIETKDFQSALYDYFIDTDKKD--KLSAVDWDLWLKSEGMPPVIPN--FDESLANVTKELASLWSS-----KSVAELADSAEIKTTISIHQLIDFLGKLIESKDIVDLNEGKINLLESTYNLKSSKNAEVRFRLNRLIIRARLIKRLDEILEFANSNFRMKFCRPIYRDLAGWPEAKPAAIRNFVNVKDQMMAVCSHTIEK 679          

Query:  625 FLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSST--LSNDVRQHKFEQKIPIPSYLVSIACGHLVGSKIG-------PRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMEN-PCIIFLTPCLLTGDKSQL-----------NYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILE----KLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKMLRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPG 1608
             + +Q   ++AR  +PC D P +K  +S +I  P   ++ +S + KS +        +  FE    +P+YLV+    ++V S++        PR  +++ P+        ++ + K L   E+  G         L+  P F +  MEN   I F    LL  +  QL             IAHE++H W GNLVT   WD  W+ EG   Y+    LE    + QS +    L     + E + D   + I +  D   T  V  +        F  + Y KG++LL  L +++G        +  +  F   ++  D+      ++  E+  +          D W  +PG
Sbjct:  426 MISTQFSPVDARRAFPCFDRPDMKANFSISIVRPMQFKMALSNMPKSGSRRFRRGFIRDDFETTPKMPTYLVAFIVSNMVDSRLASQDSGLTPRVEIWTRPQFVGMTHYAYKMVRKFLPYYEDFFGIKNKLPKIDLVSVPDFGFAAMENWGLITFRDSALLVPEDLQLASSSEHMQVVAGIIAHELAHQWFGNLVTPKWWDDLWLKEGFACYMSYKALEHAHPEFQSMDTLTMLEFKESM-EHDADNTSHAISF--DVRSTNDVRRI--------FDPISYSKGTILLRMLNSIVGDVAFRSATRDLLKKFAYGNMDRDDLWAMLTRHGHEQGTLPKDLSVKQIMDSWITQPG 767          

Query:  625 FLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSST--LSNDVRQHKFEQKIPIPSYLVSIACGHLVGSKIG-------PRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMEN-PCIIFLTPCLLTGDKSQL-----------NYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILE----KLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKMLRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPG 1608
             + +Q   ++AR  +PC D P +K  +S +I  P   ++ +S + KS +        +  FE    +P+YLV+    ++V S++        PR  +++ P+        ++ + K L   E+  G         L+  P F +  MEN   I F    LL  +  QL             IAHE++H W GNLVT   WD  W+ EG   Y+    LE    + QS +    L     + E + D   + I +  D   T  V  +        F  + Y KG++LL  L +++G        +  +  F   ++  D+      ++  E+  +          D W  +PG
Sbjct:  315 MISTQFSPVDARRAFPCFDRPDMKANFSISIVRPMQFKMALSNMPKSGSRRFRRGFIRDDFETTPKMPTYLVAFIVSNMVDSRLASQDSGLTPRVEIWTRPQFVGMTHYAYKMVRKFLPYYEDFFGIKNKLPKIDLVSVPDFGFAAMENWGLITFRDSALLVPEDLQLASSSEHMQVVAGIIAHELAHQWFGNLVTPKWWDDLWLKEGFACYMSYKALEHAHPEFQSMDTLTMLEFKESM-EHDADNTSHAISF--DVRSTNDVRRI--------FDPISYSKGTILLRMLNSIVGDVAFRSATRDLLKKFAYGNMDRDDLWAMLTRHGHEQGTLPKDLSVKQIMDSWITQPG 656          

Query:  310 HFN--WKLDFENEQISGSVVHNVKVLNSASKELILDVRNLEIKRIVIDNEDVLFQYVNGK---LGGKLVIPLSLGTKRSKFQVI-IEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVR--KSSTLSNDVRQ-HKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKM-LRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWI-----GFHQFPSSENELLNKFSRMLPDQRYYFFQVLNDIQGVQLPESSLKVMGNIYGLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMHPIT 2064
            H N  + +DF+   + G V   V+VL      L LD ++L+I ++  + +   F+ +  K    G  L I L     R +  ++ IEY T+  +TALQW+ P+ T GKKH +L+SQ QA + R++ PCQDTP VK TY A +  P +L  +MSA+R  +    S+  R  ++F Q +P+PSYL++I  G L   +IGPRS V+SE E  ++A  EF + E +L  AE L GPY W   D+L+LPPSFPYGGMENPC+ F+TP +L GD+S    IAHEISHSWTGNLVTN TW+HFW+NEGHT Y+ER+I   ++  E  R      G  EL   +      +G ++  T LVPNLH  D D++FS VPYEKG  LL++LE L+G  ++ + ++K+YI  F   SV+T+EWK + F Y  +K  +    L  + W+ W + PG  P+      D +M   C  L + W+         F  ++ + LN        Q   F  +L  +Q   LP S +K MG +Y L N  N+E+   W  +C+++ +  AV    +    QGR+K+ + L+K +Y++       V+ F   + ++HP+T
Sbjct:   20 HLNLIYHVDFDRHVLKGKVALTVEVLEDKFSSLTLDSKDLKISKVSANGQAAKFE-LGAKHKFKGSPLEITLPFELSRGQHVIVEIEYETSPTATALQWLTPKQTAGKKHPYLFSQCQATHCRTMVPCQDTPSVKHTYYAQVSVPRELVALMSALRDGQEPDPSDSSRVIYRFRQPVPMPSYLIAIVVGALESREIGPRSRVWSEKEYVDEAAYEFAETETMLKTAESLAGPYVWGQYDVLVLPPSFPYGGMENPCLTFVTPTVLAGDRSLAGVIAHEISHSWTGNLVTNRTWEHFWLNEGHTVYIERMIARCME-GEQLRQFKGIGGWKELHESVKQ----FGANNVLTNLVPNLHEVDTDEAFSSVPYEKGFALLYHLEELMGGPEVFMGFVKSYIQLFAYGSVTTEEWKNYLFTYFKDKVDI----LNKVDWNAWMHTPGMAPVRPQ--YDTTMADACTSLCQKWVKAKEADLASFTEADVKQLNS------PQLIEFMALL--LQEDPLPLSHVKKMGEVYKLNNIKNAEVRFRWLRICVKAQWEEAVPLALKMATEQGRMKFTRPLFKEVYNFSKYSDEAVKTFKENRGSLHPVT 599          

Query:  310 HFN--WKLDFENEQISGSVVHNVKVLNSASKELILDVRNLEIKRIVIDNEDVLFQYVNGK---LGGKLVIPLSLGTKRSKFQVI-IEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVR--KSSTLSNDVRQ-HKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKM-LRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWI-----GFHQFPSSENELLNKFSRMLPDQRYYFFQVLNDIQGVQLPESSLKVMGNIYGLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMHPIT 2064
            H N  + +DF+   + G V   V+VL      L LD ++L+I ++  + +   F+ +  K    G  L I L     R +  ++ IEY T+  +TALQW+ P+ T GKKH +L+SQ QA + R++ PCQDTP VK TY A +  P +L  +MSA+R  +    S+  R  ++F Q +P+PSYL++I  G L   +IGPRS V+SE E  ++A  EF + E +L  AE L GPY W   D+L+LPPSFPYGGMENPC+ F+TP +L GD+S    IAHEISHSWTGNLVTN TW+HFW+NEGHT Y+ER+I   ++  E  R      G  EL   +      +G ++  T LVPNLH  D D++FS VPYEKG  LL++LE L+G  ++ + ++K+YI  F   SV+T+EWK + F Y  +K  +    L  + W+ W + PG  P+      D +M   C  L + W+         F  ++ + LN        Q   F  +L  +Q   LP S +K MG +Y L N  N+E+   W  +C+++ +  AV    +    QGR+K+ + L+K +Y++       V+ F   + ++HP+T
Sbjct:   20 HLNLIYHVDFDRHVLKGKVALTVEVLEDKFSSLTLDSKDLKISKVSANGQAAKFE-LGAKHKFKGSPLEITLPFELSRGQHVIVEIEYETSPTATALQWLTPKQTAGKKHPYLFSQCQATHCRTMVPCQDTPSVKHTYYAQVSVPRELVALMSALRDGQEPDPSDSSRVIYRFRQPVPMPSYLIAIVVGALESREIGPRSRVWSEKEYVDEAAYEFAETETMLKTAESLAGPYVWGQYDVLVLPPSFPYGGMENPCLTFVTPTVLAGDRSLAGVIAHEISHSWTGNLVTNRTWEHFWLNEGHTVYIERMIARCME-GEQLRQFKGIGGWKELHESVKQ----FGANNVLTNLVPNLHEVDTDEAFSSVPYEKGFALLYHLEELMGGPEVFMGFVKSYIQLFAYGSVTTEEWKNYLFTYFKDKVDI----LNKVDWNAWMHTPGMAPVRPQ--YDTTMADACTSLCQKWVKAKEADLASFTEADVKQLNS------PQLIEFMALL--LQEDPLPLSHVKKMGEVYKLNNIKNAEVRFRWLRICVKAQWEEAVPLALKMATEQGRMKFTRPLFKEVYNFSKYSDEAVKTFKEIRGSLHPVT 599          

Query:  262 DKTSYANSEDFIVDKSHFNWKLDFENEQISGSVVHNVKVLNSASKELILDVR-NLEIKRIVIDNE-------DVLFQYVNGKLGGKLVIPLSLGTKRSKFQVIIEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSNDVRQHKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFED-IEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLH-GKDPDDSFSRVPYEKGSLLLFYLETLIG-KDKMLRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLNKFSRMLPDQRYYFFQVLNDIQGVQLPESSLKVMGNIYG-LTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDW-DDTKSRTVENFHIQKFAMHPITRGEIHKII 2088
            D  + ++   F ++  H + K+DF  + ISG+    ++ +  +  EL LD+  +L +  I +          + L Q         LV   +  +   K Q+ I Y  T D   + W++PE T GK   ++++Q QA+  RS +PC DTP VK+TYSA ++ P     VMSA +     ++      F  + PIP+YLV++A G L  +++GPR+ V++EP L + A+ E+++ IE  L + E+L GPY W   D+L +PPSFP+GGMENPC+ F+TPCLL GD+S  + I HEI HSW GNLVTN+TW  FW+NEG T Y +R +  +L   E Y  L    G + L   ++      G DH   KL   +  G DPDD+++  PYEKG   + YL  L G + +   +LK Y+  F+ +SV  ++   F+ +Y  E ++    K+EG+ +D W   PG  P         ++++    L + W+  H     E+            Q  YF   +  ++   LP+ +LK +   Y  +  + N+EL   W+ +  ++ Y P    + +FL+SQG+ KY   +Y+ L++  ++TK+  +E F      +H   R  + KII
Sbjct:   16 DVATSSSFRQFKIEHFHLDLKVDFLQKSISGTETIELQCIQDSQSELQLDIHPSLSVHEITLSQNARDWTRTEFLTQDFTSYGTTLLVKFPTAFSSDDKLQLAIRYTAT-DGPGVCWLEPEQTAGKLKPYVFTQGQAVLNRSCFPCFDTPAVKSTYSAAVQVPDGFTAVMSANKWEQRKADGA--FLFTMEHPIPAYLVALAVGDLQSAEVGPRTRVWTEPCLLQAAKQEYDNVIEDFLSVGEKLFGPYVWGRYDVLFMPPSFPFGGMENPCLTFVTPCLLAGDRSLADVIVHEICHSWFGNLVTNATWGDFWLNEGFTMYAQRRVCRELY-GEAYTCLEAATGKALLRQHMDN----TGEDHPLNKLRVKIEPGVDPDDTYNETPYEKGFCFVSYLAHLTGDQSRFDTFLKAYVEKFKFRSVLAEDALEFYLEYFPELKERNVHKIEGLDFDSWLNVPGWPPYVPDLSAGQTLMKPAELLAEKWLS-HNL-DLESICKTDLKSWKTYQTVYFLDRI--LEKSPLPDGNLKKLEECYSQIIKSNNAELKVRWAQIVAKNQYSPGFQHIRDFLSSQGKQKYTLPVYRALWNGSEETKALAIEMFSATSGQLHVNVRNYVKKII 625          

Query:  262 DKTSYANSEDFIVDKSHFNWKLDFENEQISGSVVHNVKVLNSASKELILDVR-NLEIKRIVIDNE-------DVLFQYVNGKLGGKLVIPLSLGTKRSKFQVIIEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSNDVRQHKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFED-IEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLH-GKDPDDSFSRVPYEKGSLLLFYLETLIG-KDKMLRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLNKFSRMLPDQRYYFFQVLNDIQGVQLPESSLKVMGNIYG-LTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDW-DDTKSRTVENFHIQKFAMHPITRGEIHKII 2088
            D  + ++   F ++  H + K+DF  + ISG+    ++ +  +  EL LD+  +L +  I +          + L Q         LV   +  +   K Q+ I Y  T D   + W++PE T GK   ++++Q QA+  RS +PC DTP VK+TYSA ++ P     VMSA +     ++      F  + PIP+YLV++A G L  +++GPR+ V++EP L + A+ E+++ IE  L + E+L GPY W   D+L +PPSFP+GGMENPC+ F+TPCLL GD+S  + I HEI HSW GNLVTN+TW  FW+NEG T Y +R +  +L   E Y  L    G + L   ++      G DH   KL   +  G DPDD+++  PYEKG   + YL  L G + +   +LK Y+  F+ +SV  ++   F+ +Y  E ++    K+EG+ +D W   PG  P         ++++    L + W+  H     E+            Q  YF   +  ++   LP+ +LK +   Y  +  + N+EL   W+ +  ++ Y P    + +FL+SQG+ KY   +Y+ L++  ++TK+  +E F      +H   R  + KII
Sbjct:   16 DVATSSSFRQFKIEHFHLDLKVDFLQKSISGTETIELQCIQDSQSELQLDIHPSLSVHEITLSQNARDWTRTEFLTQDFTSYGTTLLVKFPTAFSSDDKLQLAIRYTAT-DGPGVCWLEPEQTAGKLKPYVFTQGQAVLNRSCFPCFDTPAVKSTYSAAVQVPDGFTAVMSANKWEQRKADGA--FLFTMEHPIPAYLVALAVGDLQSAEVGPRTRVWTEPCLLQAAKQEYDNVIEDFLSVGEKLFGPYVWGRYDVLFMPPSFPFGGMENPCLTFVTPCLLAGDRSLADVIVHEICHSWFGNLVTNATWGDFWLNEGFTMYAQRRVCRELY-GEAYTCLEAATGKALLRQHMDN----TGEDHPLNKLRVKIEPGVDPDDTYNETPYEKGFCFVSYLAHLTGDQSRFDTFLKAYVEKFKFRSVLAEDALEFYLEYFPELKERNVHKIEGLDFDSWLNVPGWPPYVPDLSAGQTLMKPAELLAEKWLS-HNL-DLESICKTDLKSWKTYQTVYFLDRI--LEKSPLPDGNLKKLEECYSQIIKSNNAELKVRWAQIVAKNQYSPGFQHIRDFLSSQGKQKYTLPVYRALWNGSEETKALAIEMFSATSGQLHVNVRNYVKKII 625          

Query:  262 DKTSYANSEDFIVDKSHFNWKLDFENEQISGSVVHNVKVLNSASKELILD------VRNLEIKRIVIDNEDVLFQYVNGKL------GGKLVIPLSLGTKR--SKFQVIIEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSNDVRQHKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFE-DIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLH-GKDPDDSFSRVPYEKGSLLLFYLETLIGKDKML-RWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLNKF--SRMLPDQRYYFFQVLNDIQGVQLPESSLKVMGNIY-GLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMHPITRGEIHKIIF 2091
            D  S +N   F +   H +  L+F  ++I+G  V  +  +    + LILD      + +++ K         +F  +  ++      G  L I L     R    F+V + Y TT D  A+ W+  E+T G+    +++Q  ++  RS +PC DTP VK+TYSAT+  P  + V+MSA R  S  S   R  +F  + P+P+YLV++  G L  + IGPRS V++EP +   A  +    +E+ L +AE L GPY W   DL+ LPPSFP   MENPC+ F+   +L   +  L  + HEI+H W GN VTN+TW+  W++EG   Y +R I  +    E +  L     +  L   + +     G ++  +KL      G +P    +   YEKG   + YL  L G  K    +L+ YI  FR  SV   +   FF  +  E ++   ++ EG++++ W    GP   E       ++      L   W       + + ++++ F  S     Q   F   L D     L +  + ++ + Y  L +  N+E+   W  + +R+ + P + +V  FL+      Y   LY+ L      K   VE F+  +  +HP  R  + +I+F
Sbjct:   36 DIASASNFHCFKLRHFHLDLHLNFAVKRITGWQVLELTPVQPGVQSLILDTHPSLLIHSVDCKVPGASGAPDVFLSLTYRVEPFTDYGSSLNITLPAAVIRPHRAFRVTVRYTTT-DGPAIWWLDAELTCGQTRPLVFTQGHSVCNRSFFPCFDTPAVKSTYSATVRVPEGVTVLMSASR--SAYSKQDRVFQFSMEYPVPAYLVALVAGDLQHADIGPRSRVWAEPCILTCAVSKLGGSVERWLNVAEGLFGPYVWGRYDLVFLPPSFPIVAMENPCLTFIISSILESQEFLLIDVIHEIAHGWFGNAVTNATWEEMWLSEGLATYAQRRITTE-AYGEAFTCLETVFRLDALHRQMRL----LGDNNPVSKLQAKFEPGVNPSSLMNLFTYEKGFCFVSYLSQLCGDIKRFDSFLRAYIEKFRFSSVIAQDLLDFFLGFFPELKEGCVAQREGLEFERWLNGCGPPLCEPDLSAGRTLTGPVQHLCDLWGN----DAPDTQVISTFDLSSWSTFQTVLFLDRLLDRS--PLSQEVMSLLSSCYAALLDDMNAEVQIRWLQIVVRNSFYPDLPRVRSFLHKHTSRMYTVPLYEDLCG-GVMKCFAVEVFYQTQARLHPNLRRTLQQILF 650          

Query:  262 DKTSYANSEDFIVDKSHFNWKLDFENEQISGSVVHNVKVLNSASKELILDVRNLEIKRIVIDNEDVLFQYVNGKL--GGKLVIPLSLGTKRSKFQVIIEYN--TTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTL-SNDVRQ--HKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKM-LRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLNKFSRMLPD-QRYYFFQVLND-IQGVQLPESSLKVMGNIYGLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMHPITRGEIHK 2082
            D +S+A+ E F +   +    +DF +  I+ S    V+ L  +   LILD ++L IK++ ++ +D  F         G  L I L     R + +VI+E +  T+  S+ALQW+  E T GK H +L+SQ QA + RS+ PCQDTP VK TY + +  P +L  +MSA+R    +  ND  +  + F Q +PIPSYL+++  G L G K GPR+T+++E EL E +  EF + EK+L  AE+L GPY W   DLLILPPSFPYGGMENPC+ F+TP +L GD+S    IAHEISHSWTGNLVTN TW++FW+NEGHT YLER I + L   E +R      G  EL+  +N     +G  +  T LVPNLH  D D +FS VPYEKG  LLFYLE L+G  ++ L +LK+YI  F  KSV+T++WK F + Y  +K  +    L+ + W  W + PG  P++     D ++   C  L + W+      + E++L +  +  + D   +   +VL   +    L  S +K M  +Y L +  NSE+   W  LC+R+     +    +    QGR+K+ + LY+ LY+++  +  TV  F   +  MHP+T   + K
Sbjct:    3 DPSSFASPEKFNIKHMNLKLHVDFASCVITASTSLTVRSLQDSLASLILDTKDLTIKKVAVNGKDAKFALGTSHSFKGTPLEITLPFSLTRGQ-EVIVEIDSVTSPKSSALQWLTAEQTAGKVHPYLFSQCQATHCRSIIPCQDTPSVKFTYCSQVSVPKELVALMSALRDGELVEQNDCSRKIYCFMQNVPIPSYLIALVVGALEGRKGGPRTTIWTEKELLEPSVYEFSETEKMLKYAEDLVGPYVWGQYDLLILPPSFPYGGMENPCLTFVTPTVLAGDRSLAGVIAHEISHSWTGNLVTNETWENFWLNEGHTVYLERRI-DGLLHGEEFRQFKALGGWKELQNSVN----TFGATNPLTNLVPNLHEIDVDAAFSSVPYEKGFALLFYLEQLLGGPEIFLGFLKSYIQMFAYKSVTTEQWKNFLYSYFKDKVDI----LDKVDWKGWMHTPGMPPVQPK--YDMTLANACIALSQKWVK-----AKESDLSSFNADDVKDLSSHQLIEVLTILLLEAPLTVSHVKRMQEVYNLNDVKNSEIRFRWLRLCIRAKCEDVIPLALKMATEQGRMKFTRPLYRDLYNFEKAREETVNTFLKNRSCMHPVTEMLVAK 602          

Query:  262 DKTSYANSEDFIVDKSHFNWKLDFENEQISGSVVHNVKVLNSASKELILDVRNLEIKRIVIDNEDVLFQYVNGKL--GGKLVIPLSLGTKRSKFQVIIEYN--TTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSNDVRQHKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKM-LRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLNKFSRMLPD-QRYYFFQVLND-IQGVQLPESSLKVMGNIYGLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMHPITRGEIHK 2082
            D +S+A+ E F +   +    +DF +  I+ S    V+ L  +   LILD ++L IK++ ++ +D  F         G  L I L     R + +VI+E +  T+  S+ALQW+  E T GK H +L+SQ QA + RS+ PCQDTP VK TY + +  P +L  +MSA+R                          + C H      GPR+T+++E EL E +  EF + EK+L  AE+L GPY W   DLLILPPSFPYGGMENPC+ F+TP +L      L  IAHEISHSWTGNLVTN TW++FW+NEGHT YLER I + L   E +R      G  EL+  +N     +G  +  T LVPNLH  D D +FS VPYEKG  LLFYLE L+G  ++ L +LK+YI  F  KSV+T++WK F + Y  +K  +    L+ + W  W + PG  P++     D ++   C  L + W+      + E++L +  +  + D   +   +VL   +    L  S +K M  +Y L +  NSE+   W  LC+R+     +    +    QGR+K+ + LY+ LY+++  +  TV  F   +  MHP+T   + K
Sbjct:    6 DPSSFASPEKFNIKHMNLKLHVDFASCVITASTSLTVRSLQDSLASLILDTKDLTIKKVAVNGKDAKFALGTSHSFKGTPLEITLPFSLTRGQ-EVIVEIDSVTSPKSSALQWLTAEQTAGKVHPYLFSQCQATHCRSIIPCQDTPSVKFTYCSQVSVPKELVALMSALRDGEL----------------------VDCIH-----GGPRTTIWTEKELLEPSVYEFSETEKMLKYAEDLVGPYVWGQYDLLILPPSFPYGGMENPCLTFVTPTVLVWSFFLLIVIAHEISHSWTGNLVTNETWENFWLNEGHTVYLERRI-DGLLHGEEFRQFKALGGWKELQNSVN----TFGATNPLTNLVPNLHEIDVDAAFSSVPYEKGFALLFYLEQLLGGPEIFLGFLKSYIQMFAYKSVTTEQWKNFLYSYFKDKVDI----LDKVDWKGWMHTPGMPPVQPK--YDMTLANACIALSQKWVK-----AKESDLSSFNADDVKDLSSHQLIEVLTILLLEAPLTVSHVKRMQEVYNLNDVKNSEIRFRWLRLCIRAKCEDVIPLALKMATEQGRMKFTRPLYRDLYNFEKAREETVNTFLKNRSCMHPVTEMLVAK 575          

Query:  262 DKTSYANSEDFIVDKSHFNWKLDFENEQISGSVVHNVKVLNSASKELILDVRNLEIKRIVIDNEDVLFQYVNGKL--GGKLVIPLSLGTKRSKFQVIIEYN--TTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSNDVRQHKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKM-LRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLNKFSRMLPDQRYYFFQVLNDIQGVQLPESSLKV-----MGNIYGLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMHPITRGEIHK 2082
            D +S+A+ E F +   +    +DF +  I+ S    V+ L  +   LILD ++L IK++ ++ +D  F         G  L I L     R + +VI+E +  T+  S+ALQW+  E T GK H +L+SQ QA + RS+ PCQDTP VK TY + +  P +L  +MSA+R                          + C H      GPR+T+++E EL E +  EF + EK+L  AE+L GPY W   DLLILPPSFPYGGMENPC+ F+TP +L      L  IAHEISHSWTGNLVTN TW++FW+NEGHT YLER I + L   E +R      G  EL+  +N     +G  +  T LVPNLH  D D +FS VPYEKG  LLFYLE L+G  ++ L +LK+YI  F  KSV+T++WK F + Y  +K  +    L+ + W  W + PG  P++ +              VK   G   F  ++   L+ F+    D +      L ++  + L E+ L V     M  +Y L +  NSE+   W  LC+R+     +    +    QGR+K+ + LY+ LY+++  +  TV  F   +  MHP+T   + K
Sbjct:    7 DPSSFASPEKFNIKHMNLKLHVDFASCVITASTSLTVRSLQDSLASLILDTKDLTIKKVAVNGKDAKFALGTSHSFKGTPLEITLPFSLTRGQ-EVIVEIDSVTSPKSSALQWLTAEQTAGKVHPYLFSQCQATHCRSIIPCQDTPSVKFTYCSQVSVPKELVALMSALRDGEL----------------------VDCIH-----GGPRTTIWTEKELLEPSVYEFSETEKMLKYAEDLVGPYVWGQYDLLILPPSFPYGGMENPCLTFVTPTVLVWSFFLLIVIAHEISHSWTGNLVTNETWENFWLNEGHTVYLERRI-DGLLHGEEFRQFKALGGWKELQNSVN----TFGATNPLTNLVPNLHEIDVDAAFSSVPYEKGFALLFYLEQLLGGPEIFLGFLKSYIQMFAYKSVTTEQWKNFLYSYFKDKVDI----LDKVDWKGWMHTPGMPPVQPN--------------VKILHGI--FSQAKESDLSSFNA--DDVKDLSSHQLIEVLTILLLEAPLTVSHVKRMQEVYNLNDVKNSEIRFRWLRLCIRAKCEDVIPLALKMATEQGRMKFTRPLYRDLYNFEKAREETVNTFLKNRSCMHPVTEMLVAK 568          

Query:  376 VLNSASKELILDVRNLEIKRIVIDNEDVLFQYVNGKL--GGKLVIPLSLGTKRSKFQVIIEYN--TTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTL-SNDVRQ--HKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKM-LRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLNKFSRMLPD-QRYYFFQVLND-IQGVQLPESSLKVMGNIYGLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMHPITRGEIHK 2082
            +L S  +  ILD ++L IK++ ++ +D  F         G  L I L     R + +VI+E +  T+  S+ALQW+  E T GK H +L+SQ QA + RS+ PCQDTP VK TY + +  P +L  +MSA+R    +  ND  +  + F Q +PIPSYL+++  G L G                      F   EK+L  AE+L GPY W   DLLILPPSFPYGGMENPC+ F+TP +L      L  IAHEISHSWTGNLVTN TW++FW+NEGHT YLER I + L   E +R      G  EL+  +N     +G  +  T LVPNLH  D D +FS VPYEKG  LLFYLE L+G  ++ L +LK+YI  F  KSV+T++WK F + Y  +K  +    L+ + W  W + PG  P++     D ++   C  L + W+      + E++L +  +  + D   +   +VL   +    L  S +K M  +Y L +  NSE+   W  LC+R+     +    +    QGR+K+ + LY+ LY+++  +  TV  F   +  MHP+T   + K
Sbjct:   20 ILESCLELHILDTKDLTIKKVAVNGKDAKFALGTSHSFKGTPLEITLPFSLTRGQ-EVIVEIDSVTSPKSSALQWLTAEQTAGKVHPYLFSQCQATHCRSIIPCQDTPSVKFTYCSQVSVPKELVALMSALRDGELVEQNDCSRKIYCFMQNVPIPSYLIALVVGALEGF---------------------FSFTEKMLKYAEDLVGPYVWGQYDLLILPPSFPYGGMENPCLTFVTPTVLVWSFFLLIVIAHEISHSWTGNLVTNETWENFWLNEGHTVYLERRI-DGLLHGEEFRQFKALGGWKELQNSVN----TFGATNPLTNLVPNLHEIDVDAAFSSVPYEKGFALLFYLEQLLGGPEIFLGFLKSYIQMFAYKSVTTEQWKNFLYSYFKDKVDI----LDKVDWKGWMHTPGMPPVQPK--YDMTLANACIALSQKWVK-----AKESDLSSFNADDVKDLSSHQLIEVLTILLLEAPLTVSHVKRMQEVYNLNDVKNSEIRFRWLRLCIRAKCEDVIPLALKMATEQGRMKFTRPLYRDLYNFEKAREETVNTFLKNRSCMHPVTEMLVAK 560          

Query:  376 VLNSASKELILDVRNLEIKRIVIDNEDVLFQYVNGKL--GGKLVIPLSLGTKRSKFQVIIEYN--TTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTL-SNDVRQ--HKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKM-LRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLNKFSRMLPDQRYYFFQVLNDIQGVQLPESSLKVMGNIYGLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMHPITRGEIHK 2082
            +L S  +  ILD ++L IK++ ++ +D  F         G  L I L     R + +VI+E +  T+  S+ALQW+  E T GK H +L+SQ QA + RS+ PCQDTP VK TY + +  P +L  +MSA+R    +  ND  +  + F Q +PIPSYL+++  G L G                      F   EK+L  AE+L GPY W   DLLILPPSFPYGGMENPC+ F+TP +L      L  IAHEISHSWTGNLVTN TW++FW+NEGHT YLER I + L   E +R      G  EL+  +N     +G  +  T LVPNLH  D D +FS VPYEKG  LLFYLE L+G  ++ L +LK+YI  F  KSV+T++WK F + Y   K+KV+   L+ + W  W + PG  P++     D ++   C  L + W+              K S +     +Y+   L       L  S +K M  +Y L +  NSE+   W  LC+R+     +    +    QGR+K+ + LY+ LY+++  +  TV  F   +  MHP+T   + K
Sbjct:   20 ILESCLELHILDTKDLTIKKVAVNGKDAKFALGTSHSFKGTPLEITLPFSLTRGQ-EVIVEIDSVTSPKSSALQWLTAEQTAGKVHPYLFSQCQATHCRSIIPCQDTPSVKFTYCSQVSVPKELVALMSALRDGELVEQNDCSRKIYCFMQNVPIPSYLIALVVGALEGF---------------------FSFTEKMLKYAEDLVGPYVWGQYDLLILPPSFPYGGMENPCLTFVTPTVLVWSFFLLIVIAHEISHSWTGNLVTNETWENFWLNEGHTVYLERRI-DGLLHGEEFRQFKALGGWKELQNSVNT----FGATNPLTNLVPNLHEIDVDAAFSSVPYEKGFALLFYLEQLLGGPEIFLGFLKSYIQMFAYKSVTTEQWKNFLYSYF--KDKVD--ILDKVDWKGWMHTPGMPPVQPK--YDMTLANACIALSQKWV--------------KVSGITCYVIHYYCAFLFQ---APLTVSHVKRMQEVYNLNDVKNSEIRFRWLRLCIRAKCEDVIPLALKMATEQGRMKFTRPLYRDLYNFEKAREETVNTFLKNRSCMHPVTEMLVAK 546          

Query:  310 HFNWKLDFENEQISGSVVHNVKVLNSASKELILDVRNLEIKRIVIDNEDVLFQYVNGKLGG------KLVIPLSLGTKRSKFQVIIEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSND---VRQHKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKM-LRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLNKFSRMLPDQRYYFFQVLND-----IQGVQLPESSLKVMGNIYGLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMHPIT 2064
            H    +DF    ++G+    V+      + L LD ++L I+++VI+ ++V  +Y  G+  G      ++ +P++L +K  +  + I + T+  S+ALQW+ PE T GK+H +L+SQ QAI+ R++ PCQDTP VK TY+A +  P +L  +MSA+R       +    + ++F Q++PIP YL+++  G L   +IGPR+ V+SE E  EK+  EF + E +L IAE+L GPY W   DLL+LPPSFPYGGMENPC+ F+TP LL GDKS  N IAHEISHSWTGNLVTN TWDHFW+NEGHT YLER I  +L   E +RH H   G  EL+  +      +G  H FTKLV +L   DPD ++S +PYEKG  LLFYLE L+G  ++ L +LK Y+  F  +SV+TD+WK+F + +   K+KV+   L  + W+ W Y PG  P++ +   D ++   C  L + W+      +++ E L+ FS  + D +      LN+     +Q   LP   +K M  +Y      NSE+   W  LC++S +  A+    +    QGR+K+ + L+K L  +D +  + V  +   K +MHP+T
Sbjct:   23 HLRCSVDFARRTLTGTAALTVQSQEENLRSLTLDTKDLTIEKVVINGQEV--KYTLGESQGYKGSPMEISLPIAL-SKNQEIVIEISFETSPKSSALQWLTPEQTSGKQHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGEAPDPEDPSRKIYRFNQRVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSANEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRL-FGEKFRHFHALGGWGELQNTIK----TFGESHPFTKLVVDLKDVDPDVAYSSIPYEKGFALLFYLEQLLGGPEVFLGFLKAYVKKFSYQSVTTDDWKSFLYSHF--KDKVD--LLNQVDWNTWLYAPGLPPVKPN--YDVTLTNACIALSQRWV------TAKEEDLSSFS--IADLKDLSSHQLNEFLAQVLQKAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEEAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVHTYQEHKASMHPVT 600          

Query:  532 KFQVIIEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSNDVRQHKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFED-IEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLH-GKDPDDSFSRVPYEKGSLLLFYLETLIG-KDKMLRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLNKFSRMLPDQRYYFFQVLNDIQGVQLPESSLKVMGNIY-GLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDD-TKSRTVENFHIQKFAMHPITRGEIHKIIFPR 2097
            +F++ + Y    +   + W+ PE T GKK  F+Y+Q QA+  R+ +PC DTP VK TYSA IE P     VMSA        N   +  F+   PIPSYL+++A G L  +++GPRS V++EP L E A+ E+   IE+ L   E+L GPY W   DLL +PPSFP+GGMENPC+ F+TPCLL GD+S  + I HEISHSW GNLVTN+ W  FW+NEG T Y +R I   L  +  Y  L    G + L   +N    + G ++   KL   +  G DPDD+++  PYEKG   + YL  L+G +D+  ++LK Y+  F+ +S+  +++  F+ +Y  E +K     + G ++D W   PG  P        DS+++   EL + W+     P  +       S     Q  YF   +  +Q   LP  ++K +G  Y  ++N  N+EL   W  + L++ Y     +V +FL SQG+ KY   LY  +    +  ++   + F      +H      + +I+ P+
Sbjct:  135 RFELELTYRV-GEGPGVCWLAPEQTAGKKKPFVYTQGQAVLNRAFFPCFDTPAVKCTYSALIEVPDGFTAVMSADTWEKRGPN---KFFFQMSHPIPSYLIALAIGDLASAEVGPRSRVWAEPCLIEAAKEEYSGVIEEFLATGEKLFGPYVWGRYDLLFMPPSFPFGGMENPCLTFVTPCLLAGDRSLADVIIHEISHSWFGNLVTNANWGEFWLNEGFTMYAQRRISTILFGAA-YTCLEAATGRALLRQHMN----VSGEENPLNKLRVKIEPGVDPDDTYNETPYEKGYCFVSYLAHLVGDQDQFDKFLKAYVDEFKFQSILAEDFLEFYLEYFPELKKKGVDSIPGFEFDRWLNTPGWPPYLPDLSPGDSLMKPAEELAELWVTSE--PDMQAIEAVAISTWKTYQLVYFLDKI--LQKSPLPPGNVKKLGETYPKISNAQNAELRLRWGQIILKNDYQEEFQKVKDFLQSQGKQKYTLPLYHAMMGGSEMARTLAKDTFAATASQLHSNVVNYVQQILAPK 648          

Query:  532 KFQVIIEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSNDVRQHKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLH-GKDPDDSFSRVPYEKGSLLLFYLETLIG-KDKMLRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLNKFSRMLPDQRYYFFQVLNDIQGVQLPESSLKVMGNIY-GLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDD-TKSRTVENFHIQKFAMHPITRGEIHKIIFPR 2097
            +F++ + Y    +   + W+ PE T GKK  F+Y+Q QA+  R+ +PC DTP VK TYSA IE P     VMSA        N   +  F+   PIPSYL+++A G L  +++GPR                                       DLL +PPSFP+GGMENPC+ F+TPCLL GD+S  + I HEISHSW GNLVTN+ W  FW+NEG T Y +R I   L  +  Y  L    G + L   +N    + G ++   KL   +  G DPDD+++  PYEKG   + YL  L+G +D+  ++LK Y+  F+ +S+  +++  F+ +Y  E +K     + G ++D W   PG  P        DS+++   EL + W+     P  +       S     Q  YF   +  +Q   LP  ++K +G  Y  ++N  N+EL   W  + L++ Y     +V +FL SQG+ KY   LY  +    +  ++   + F      +H      + +I+ P+
Sbjct:  135 RFELELTYRV-GEGPGVCWLAPEQTAGKKKPFVYTQGQAVLNRAFFPCFDTPAVKCTYSALIEVPDGFTAVMSADTWEKRGPN---KFFFQMSHPIPSYLIALAIGDLASAEVGPRY--------------------------------------DLLFMPPSFPFGGMENPCLTFVTPCLLAGDRSLADVIIHEISHSWFGNLVTNANWGEFWLNEGFTMYAQRRISTILFGAA-YTCLEAATGRALLRQHMN----VSGEENPLNKLRVKIEPGVDPDDTYNETPYEKGYCFVSYLAHLVGDQDQFDKFLKAYVDEFKFQSILAEDFLEFYLEYFPELKKKGVDSIPGFEFDRWLNTPGWPPYLPDLSPGDSLMKPAEELAELWVTSE--PDMQAIEAVAISTWKTYQLVYFLDKI--LQKSPLPPGNVKKLGETYPKISNAQNAELRLRWGQIILKNDYQEEFQKVKDFLQSQGKQKYTLPLYHAMMGGSEMARTLAKDTFAATASQLHSNVVNYVQQILAPK 609          

Query:  535 FQVIIEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSNDVRQHKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFED-IEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLH-GKDPDDSFSRVPYEKGSLLLFYLETLIGKDKML-RWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLNKFSRMLPDQRYYFFQVLNDIQGVQLPESSLKVMGNIY-GLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMHPITRGEIHKII 2088
            FQVI+ Y +T D+ A+ W+ PE+T G    F+++Q  ++  RS +PC DTP VK TYSA ++AP  ++V+MSA +  S    +   + F  + P+P+YLV++  G L  + IGPRS V++EP L   A  +    +E+ L  AE L GPY W   D++ LPPSFP   MENPC+ F+   +L  D+  +  + HE++HSW GN VTN+TW+  W++EG   Y +R I     ++E Y      L  +     L+    + G D   +KL   L  G +P    +   YEKG   ++YL  L G  +    +L+ Y+  ++  SV   +    F  +  E ++       G++++ W    GP   E       S+ +    L + W       ++ +      S+    Q   F   L D  G  LP+  +  +   Y  L ++ N+E+   W  + +R+ Y P + +V  FL SQ    Y   LY+ L      KS  +E F+  +  +HP  R  I +I+
Sbjct:  158 FQVILRYTST-DAPAIWWLDPELTYGNAKPFVFTQGHSVCNRSFFPCFDTPAVKCTYSAVVKAPLGVQVLMSATQ--SVYVEEEGLYHFHMEHPVPAYLVALVAGDLKPADIGPRSRVWAEPCLLPTATSKLSGAVEQWLSAAERLYGPYMWGRYDIVFLPPSFPIVAMENPCLTFIISSILESDEFLVIDVIHEVAHSWFGNAVTNATWEEMWLSEGLATYAQRRI-----TTETYGAAFTCLETAFRLDALHRQMRLLGEDSPVSKLQVKLEPGVNPSHLMNLFTYEKGYCFVYYLSQLCGGPQRFDDFLRAYVEKYKFTSVVAQDLLDSFLSFFPELKEQSVDCRAGLEFERWLNATGPPLAEPDLSQGSSLTRPVEALFQLWTAEPLEQAAASASAIDISKWRTFQTALFLDRLLD--GSPLPQEVVMSLSKCYSSLLDSMNAEIRIRWLQIVVRNDYYPDLHRVRRFLESQMSRMYTIPLYEDLCT-GALKSFALEVFYQTQGRLHPNLRRTIQQIL 668          

Query:  541 VIIEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSA--VRKSSTLSNDVRQHKFEQKIPIPS--YLVSIACGHLVGSKIGPRSTVYSE---PELNEKARLEFED-------------------------------------------IEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLN-YIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQI------------IYGPDHEFTKLVPNL------HGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKMLRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPG-PIPIEHHSLLDDS----MIQECNELVKAWIGFHQFPSSENELLNK--FSRMLPDQRYYFFQVLNDIQGVQLPESSLKVMGNIYGLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFL 1941
            + I Y T  +  ++ W     T       +Y+    IN R+L+PCQ+ P   +T+ AT+ A +   V+MS     K + L        +   +P+P+  + +++ C   +  K  P   + +E   P    +A L +++                                           I   L  A  + G + +   D+LI+P +FP  GM +P IIFL+   LTG        + HEI+HSW G  +    W   W++EG   +LE +   + Q   P    H  L   EL   L  +++            +  P+ E T  V         HG +P+  F +V Y KG  LL +L   +G+     +L+ ++  F  + + + ++     + + E +++  S    ++  DW    G P  ++     +D     + ++    V  WI  ++ P        +  F ++ PDQ     + L  ++   L   +L  +   Y L    ++E+ H W  L ++  Y  A +QV  FL
Sbjct:  136 IRIWYKTKPEGQSVAWT----TDQNGRPCVYTMGSPINNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGENSAKPTPLREGYMSWHYYVTMPMPASTFAIAVGCWTEMKPKASPPDDLMTEHSLPLSPSEADLRYDNTCNHMEYPCRFQSASAASQDIIPYRVFAPVCLEGACQEALLWLIPSCLSAAHSVLGTHPFSRLDILIVPTNFPSLGMASPHIIFLSQSTLTGTSHLCGTRLCHEIAHSWFGLAIGARDWTEEWLSEGFATHLEDIFWAEAQQLPP----HEALEQQELRACLRWHRLQDELRNSPEGMQVLRPNKEETGHVSASGASVVKHGLNPEKGFMQVHYLKGYFLLRFLTRTLGEKIYFPFLRKFVHLFHGQLILSQDFLQMLLENIPENKRLGLSVENIVR--DWLECSGIPKALQEERKAEDCSPSRLARQVGSEVAKWIRVNRRPRKRKRGKREVAFEKLSPDQIVLLLEWL--LEQKTLSPQTLHCLQQTYHLPE-QDAEVRHRWCELVIKHKYTKAYNQVERFL 665          

Query:  310 HFNWKLDFENEQISGSVVHNVKVLNSASKELILDVRNLEIKRIVIDNEDVLFQYVNGKL----GGKLVIPLSLGTKRSKFQVI-IEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSND---VRQHKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKM-LRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLNKFSRMLPDQRYYFFQVLND-----IQGVQLPESSLKVMGNIYGLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMHPIT 2064
            H    +DF    +SG+    ++      + LILD ++L I+++VI+ ++V  +Y  G+     G  + I L +   +++  VI I + T+  S+ALQW+ PE T GK+H +L+SQ QAI+ R++ PCQDTP VK TYSA +  P +L  +MSA+R       +    + ++F QK+PIP YL+++  G L   +IGPR+ V+SE E  EK+  EF + E +L IAE+L GPY W   DLL+LPPSFPYGGMENPC+ F+TP LL GDKS  N IAHEISHSWTGNLVTN TWDHFW+NEGHT YLER I  +L   E +RH H   G  EL+  +      +G  H FTKLV +L   DPD ++S VPYEKG  LLFYLE L+G  ++ L +LK Y+  F  KS++TD WK F + +  +K  +    L  + W+ W Y PG  P++ +   D ++   C  L + WI      +++++ LN FS    D + +    +N+     +Q   LP   +K M  +Y      NSE+   W  LC++S +  A+    +    QGR+K+ + L+K L  +D +  + +  +   K +MHP+T
Sbjct:   23 HLRCSIDFTRRVLSGTAALTIQSQEDNLRSLILDTKDLTIEKVVINGQEV--KYTLGERQSYKGSPIEISLPIALCKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYSAEVSVPKELVALMSAIRDGEAPDPEDPNRKIYRFSQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYIWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRL-FGEKFRHFHALGGWGELQNSIK----TFGETHPFTKLVVDLTNTDPDVAYSSVPYEKGFALLFYLEQLLGGPEVFLGFLKAYVEKFSYKSITTDNWKDFLYSHFKDKVDI----LNQVDWNTWLYSPGLPPVKPN--YDMTLTNACISLSQRWI------TAKDDDLNSFSSA--DLKDFSSHQVNEFLAQMLQNAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEEAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAIRTYKEHKASMHPVT 600          

Query:  310 HFNWKLDFENEQISGSVVHNVKVLNSASKELILDVRNLEIKRIVIDNEDVLFQYVNGKL----GGKLVIPLSLGTKRSKFQVI-IEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSND---VRQHKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKM-LRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLNKFSRMLPDQRYYFFQVLND-----IQGVQLPESSLKVMGNIYGLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMHPIT 2064
            H    +DF    ++G+    V+      + L+LD ++L I+++VI+ ++V  +Y  G+     G  + I L +   +++  VI I + T+  S+ALQW+ PE T GK+H +L+SQ QAI+ R++ PCQDTP VK TY+A +  P +L  +MSA+R   T   +    + +KF QK+PIP YL+++  G L   +IGPR+ V+SE E  EK+  EF + E +L IAE+L GPY W   DLL+LPPSFPYGGMENPC+ F+TP LL GDKS  N IAHEISHSWTGNLVTN TWDHFW+NEGHT YLER I  +L   E +RH +   G  EL+  +      +G  H FTKLV +L   DPD ++S VPYEKG  LLFYLE L+G  ++ L +LK Y+  F  KS++TD+WK F + Y  +K  V    L  + W+ W Y PG  PI+ +   D ++   C  L + WI      +++ + LN F+    D +      LN+     +Q   LP   +K M  +Y      NSE+   W  LC++S +  A+    +    QGR+K+ + L+K L  +D +  + V  +   K +MHP+T
Sbjct:   23 HLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEV--KYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRL-FGEKFRHFNALGGWGELQNSVK----TFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDV----LNQVDWNAWLYSPGLPPIKPN--YDMTLTNACIALSQRWI------TAKEDDLNSFNAT--DLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVT 600          

Query:  310 HFNWKLDFENEQISGSVVHNVKVLNSASKELILDVRNLEIKRIVIDNEDVLFQYVNGKL----GGKLVIPLSLGTKRSKFQVI-IEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSND---VRQHKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKM-LRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLNKFSRM-LPDQRY-----YFFQVLNDIQGVQLPESSLKVMGNIYGLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMHPIT 2064
            H    +DF +  ++G     ++      + L+LD + L I+++VI+ ++V  +Y  G+     G  + I L +   +++  VI I + T+  S+ALQW+ PE T GK+H +L+SQ QAI+ R++ PCQDTP VK TY+A +  P +L  +MSAVR   T   +    + +KF QK+PIP YL+++  G L   KIGPR+ V+SE E  EK+  EF + E +L IAE+L GPY W   DLL+LPPSFPYGGMENPC+ F+TP LL GDKS  N IAHEISHSWTGNLVTN TWDHFW+NEGHT YLER I  +L   E +RH H   G  EL+  +      +G  H FTKLV +L   DPD ++S VPYEKG  LLF+LE L+G  ++ L +LK Y+  F  KS++TD+WK F + +  +K  +    L  + W+ W Y PG  P++ +   D ++   C  L + WI      +++ E LN F+   L D        +  QVL   Q   LP   +K M  +Y      NSE+   W  LC++S +  A+    +    QGR+K+ + L+K L  +D +  + +  +   K +MHP+T
Sbjct:   23 HLRCSVDFSSRALTGIAALTIQSQEDNLRSLVLDTKALTIEKVVINGQEV--KYALGERQSYKGSPMEISLPIALSKNQEVVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAVLPCQDTPSVKLTYTAEVSVPKELVALMSAVRDGETPDPEDPSRKIYKFNQKVPIPCYLIALVVGALESRKIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRL-FGEKFRHFHALGGWGELQNTIK----TFGETHPFTKLVVDLTDVDPDVAYSSVPYEKGFALLFHLEQLLGGPEVFLGFLKAYVERFSYKSITTDDWKNFLYSHFKDKVDI----LNQVDWNAWLYSPGLPPVKPN--YDMTLTNACIALSQRWI------TAKEEDLNTFNATDLKDLSTHQVNEFLAQVL---QQAPLPLGHVKRMQEVYNFNAVNNSEIRFRWLRLCIQSKWEEAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAIRTYQAHKASMHPVT 600          

Query:  310 HFNWKLDFENEQISGSVVHNVKVLNSASKELILDVRNLEIKRIVIDNEDVLFQYVNGKLGG------KLVIPLSLGTKRSKFQVIIEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSND---VRQHKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKM-LRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLNKFSRMLPDQRYYFFQVLND-----IQGVQLPESSLKVMGNIYGLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMHPIT 2064
            H    +DF    ++G+    V+      + L LD ++L I+++VI+ ++V  +Y  G+  G      ++ +P++L +K  +  + I + T+  S+ALQW+ PE T GK+H +L+SQ QAI+ R++ PCQDTP VK TY+A +  P +L  +MSA+R       +    + ++F Q++PIP YL+++  G L   +IGPR+ V+SE E  EK+  EF + E +L IAE+L GPY W   DLL+LPPSFPYGGMENPC+ F+TP LL GDKS  N IAHEISHSWTGNLVTN TWDHFW+NEGHT YLER I  +L   E +RH H   G  EL+  +      +G  H FTKLV +L   DPD ++S +PYEKG  LLFYLE L+G  ++ L +LK Y+  F  +SV+TD+WK+F + +   K+KV+   L  + W+ W Y PG  P++ +   D ++   C  L + W+      +++ E L+ FS  + D +      LN+     +Q   LP   +K M  +Y      NSE+   W  LC++S +  A+    +    QGR+K+ + L+K L  +D +  + V  +   K +MHP+T
Sbjct:   23 HLRCSVDFARRTLTGTAALTVQSQEENLRSLTLDTKDLTIEKVVINGQEV--KYTLGESQGYKGSPMEISLPIAL-SKNQEIVIEISFETSPKSSALQWLTPEQTSGKQHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGEAPDPEDPSRKIYRFNQRVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSANEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRL-FGEKFRHFHALGGWGELQNTIK----TFGESHPFTKLVVDLKDVDPDVAYSSIPYEKGFALLFYLEQLLGGPEVFLGFLKAYVKKFSYQSVTTDDWKSFLYSHF--KDKVD--LLNQVDWNTWLYAPGLPPVKPN--YDVTLTNACIALSQRWV------TAKEEDLSSFS--IADLKDLSSHQLNEFLAQVLQKAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEEAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVHTYQEHKASMHPVT 600          

Query:  310 HFNWKLDFENEQISGSVVHNVKVLNSASKELILDVRNLEIKRIVIDNEDVLFQYVNGKL----GGKLVIPLSLGTKRSKFQVI-IEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVR--KSSTLSNDVRQ-HKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKM-LRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLNKFSRM-LPDQRY-----YFFQVLNDIQGVQLPESSLKVMGNIYGLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMHPIT 2064
            H    +DF    ++G     ++      + LILD ++L I+++VI+ ++V  +Y  G+     G  + I L +   +++  VI I + T+  S+ALQW+ PE T GK+H +L+SQ QAI+ R+  PCQDTP VK TY+A +  P +L  +MSA+R  ++   ++  R+ +KF QK+PIP YL+++  G L   KIGPR+ V+SE E  +K+  EF + E +L IAE+L GPY W   D L+LPPSF YGGMENPC+ F+TP LL GDKS  N IAHEISH+WTGNLVTN TWDHFW+NEGHT YLER I  +L   E +RH H   G  EL+  +       G    FTKLV +L   DPD ++S VPYEKG  LLF+LE L+G  ++ L +LK Y+  F  KS++TD+WK F F +  +K  +    L  + WD W Y PG  PI+ +   D ++   C  L + WI      +++ + LN FS   L D        +  QVL   Q   LP   +K M  +Y      NSE+   W  LC++S +  A+    +    QGR+K+ + L+K L  +D +  + ++ +H  K +MHP+T
Sbjct:   23 HLRCSVDFTRRALTGVAALTIQSQEDNLRSLILDTKDLTIEKVVINGQEV--KYALGEKQSYKGSPMEISLPIALSKNQEVVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAFLPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGEAPDPADPSRKIYKFSQKVPIPCYLIALVVGALESRKIGPRTLVWSEKEQVDKSAYEFSETESMLKIAEDLGGPYVWGQYDRLVLPPSFSYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHTWTGNLVTNKTWDHFWLNEGHTVYLERHICGRL-FGEKFRHFHALGGWGELQNTVK----TLGETQAFTKLVVDLTDTDPDVAYSSVPYEKGFALLFHLEQLLGGPEVFLGFLKAYVEKFSYKSITTDDWKNFLFSHFKDKVDI----LNQVDWDAWLYSPGLPPIKPN--YDMTLTNACIALSQRWI------TAKEKDLNTFSATDLKDLSSHQVNEFLAQVL---QRAPLPLGHVKRMQEVYNCNAINNSEIRFRWLRLCIQSKWEEAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAIQTYHAHKASMHPVT 600          

Query:  262 DKTSYANSEDFIVDKSHFNWKLDFENEQISGSVVHNVKVLN--SASKELILDVRNLEIKRIVIDNEDVLFQYVNGK---LGGKLVIPLSLGTKRSKFQVIIEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVR-KSSTLSNDVRQ---HKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKMLRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSE--------NELLNKFSRMLPDQRYYFFQVLNDIQGVQLPESSLKVMGNIYGLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMH 2055
            D +S AN+ D+      F+W +DF  + I G+ V  +K ++   A   LILD   L I+ + I   DV ++ V  K   LG   V+ +++ +   +F V I Y T+ +S+ALQW++PE+T  +K  F++SQ QAI+ARSL+PCQDTP VK T+ A + AP +  VVM  VR K  ++SN   Q   + +EQ IPIPSYLV+IACG L   ++GPRS+V++E  +  KA  EF DIEK+L  AE LCGPY W++ D+L+LPPSFPYGGMENPC+ F++P LL GDKS +N IAHEI+HSWTGN VTNS W+HFW+NEGHT YLERLI+E L  ++  RHL + +G  EL  ++       G  HEFT+LV  L G DPD S++R+PYEKGSLLL+YLET  G+DKM+ WLK Y+  F   ++ T+ W  F  K + E+ +      + + WD+W + PG +P        +  I +C+ LV        F S E          +L  +  + P QR    + LN  +  +L   +L+ +     L+   N+EL   WS  C+RSHY+PA+D   EFLNS GR++Y + LY+ L  W +  +R  EN+  Q+  MH
Sbjct:    6 DPSSSANASDYHTAHIKFDWNIDFTTKTIGGAAVLTIKRVSHEKAHPPLILDANELSIQAVKIHGNDVQWKCVPHKHPVLGS--VLEVTVPSSDPQFDVEIAYKTSPNSSALQWLEPELTADRKLPFMFSQCQAIHARSLFPCQDTPSVKATFEAVVHAPKEAVVVMGGVRTKQPSVSNRGDQWMTYHYEQTIPIPSYLVTIACGDLASERVGPRSSVWAERSVVAKAAKEFADIEKMLAAAEHLCGPYVWKVYDVLVLPPSFPYGGMENPCLTFVSPTLLAGDKSLVNVIAHEIAHSWTGNFVTNSNWEHFWLNEGHTIYLERLIMEYLHGTQ-MRHLLLAIGYEELLNEVKH----LGTTHEFTRLVTKLDGVDPDVSYNRIPYEKGSLLLYYLETKFGRDKMMHWLKAYVKHFGGSALDTNSWVEFLSKTLGEEAQ------KNVNWDEWLHAPG-MPSWKPKFEAEEAIAQCDSLVAL------FESDELSTKSAVTASVLKLWKELSPIQRELTMRRLN--KRPELKHENLRAIDAALELSKQQNAELRFEWSHACIRSHYLPALDSCLEFLNSTGRMRYTRPLYRSLKQWPEVLTRVHENYKNQRPFMH 598          

Query:  262 DKTSYANSEDFIVDKSHFNWKLDFENEQISGSVVHNVKVLN--SASKELILDVRNLEIKRIVIDNEDVLFQYVNGK---LGGKLVIPLSLGTKRSKFQVIIEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVR-KSSTLSNDVRQ---HKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKMLRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIG--FHQFPSSENELLNKFSRMLPDQRYYFFQVLNDIQGVQLPESSLKVMGNIYGLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMH 2055
            D +S AN+  +      F+W +DF  + I G+ V  +K ++       LILD   L I+ + I   DV ++ V  K   LG   V+ +++ +   +F V I Y T+ +S+ALQW++PE+T  +K  F++SQ QAI+ARSL+PCQDTP VK T+ A + AP +  VVM  VR K  ++SN   Q   + +EQ IPIPSYLV+IACG L   ++GPRS+V++E  +  KA  EF DIEK+L  AE LCGPY W++ D+L+LPPSFPYGGMENPC+ F++P LL GDKS +N IAHEI+HSWTGN VTNS W+HFW+NEGHT YLERLI+E L  ++  RHL + +G  EL  ++N      G  HEFT+LV  L G DPD S++R+PYEKGSLLL+YLET  G+DKM+ WLK Y+  F   ++ T+ W  F  K + E+     +K + + WD+W + PG +P        +  I +C+ LV  +         +    +L  +  + P QR    + LN  +  +L   +L+ +     L+   N+EL   WS  C+RSHY+PA+D   EFLNS GR++Y + LY+ L  W +  +R  EN+  Q+  MH
Sbjct:   73 DPSSSANASHYHTAHIKFDWNIDFTTKTIGGAAVLTIKRVSHEKTHPPLILDANELSIQAVKIHGNDVQWKCVPHKHPVLGS--VLEVTVPSSDPQFDVEIAYKTSPNSSALQWLEPELTADRKLPFMFSQCQAIHARSLFPCQDTPSVKATFEAVVHAPKEAVVVMGGVRTKQPSVSNRGDQWMIYHYEQTIPIPSYLVTIACGDLASERVGPRSSVWAERSVVAKAAKEFSDIEKMLAAAEHLCGPYVWKVYDVLVLPPSFPYGGMENPCLTFVSPTLLAGDKSLVNVIAHEIAHSWTGNFVTNSNWEHFWLNEGHTIYLERLIMEYLHGTQ-MRHLLLAIGYEELLNEVNH----LGTTHEFTRLVTKLDGVDPDVSYNRIPYEKGSLLLYYLETRFGRDKMMHWLKAYVKQFGGSALDTNSWVEFLSKTLGEE-----AKEKNVNWDEWLHAPG-MPSWKPKFEAEEAIAQCDSLVALFESDELSTKSAVTASVLKLWKELSPIQRELTMRRLN--KRPELKHENLRAIDAALELSKQQNAELRFEWSHACIRSHYLPALDSCLEFLNSTGRMRYTRPLYRSLKQWPEVLTRVHENYKNQRPFMH 666          

Query:  259 NDKTSYANSEDFIVDKSHFNWKLDFENEQISGSVVHNVKVLN---SASKELILDVRNLEIKRIVIDNEDVLFQYVNGK---LGGKLVIPLSLGTKRSKFQVIIEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSNDVRQ----HKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKMLRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIP-IEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLNKFSRMLPDQRYYFFQVLNDIQGVQLPESSLKVMGNIYGLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMHPITRGEIHKII 2088
             D +S +N E F+     F+WK+DF    +SG V  ++  L+   + S  L LD++++ +  + I+ +   F   NG    LG  L +   +G +RS F V+IEY+TT  S+ALQW+  +MT  KK  FL++Q QAI+ARSL+PCQDTP VK TY+A + AP  + V+MSA R +S    D  +    H F Q IPIPSYLV++ACG LV ++IG RS V++EP +  +A+LEF +++ ++  AE LCG YEW I D+L+LPPSFPYGGMENPC+ F+TP LL GD+S  + IAHEISHSWTGNLVTN++W+HFW+NEGHT Y+E L+LE L  ++ YR L I LG  EL+  L  ++      H   K+VP L G   DD+FS +PY+KGSLLL+YLE   GK  +L WLK+YI+ FR  S+ST  W  F   ++ +      + L+ + W++W Y  GPIP +        S++ +  E +++         S   +  ++  M+P QR   +Q L  ++ + L   +L+V+ ++  ++ + N+E+ + WSL+ L S Y+P VD   EFLNSQGR+K+ + +YK L  W   + + + NF   +  +HP T   + K I
Sbjct:   18 QDPSSQSNPELFVTQHVDFDWKVDFNARVLSGKVTLHMTPLDLYSADSVALKLDIKDINVLCVNINEKPAEFTIQNGSHPNLGNVLCV--DVGYQRSGFTVVIEYDTTPQSSALQWLDAQMTADKKCPFLFTQCQAIHARSLFPCQDTPRVKFTYTACVIAPPGVTVLMSAQRPTSPRHCDEPESPSMHFFTQDIPIPSYLVALACGELVSARIGSRSLVWAEPSVLPRAQLEFNEVDTLIAAAESLCGEYEWGIYDILVLPPSFPYGGMENPCLTFVTPTLLAGDRSLTSVIAHEISHSWTGNLVTNASWEHFWLNEGHTKYVEGLVLELLYGTD-YRELFIELGYEELQICLGEFK----EGHPLAKMVPCLTGVHTDDAFSVIPYQKGSLLLYYLEQTYGKAAILSWLKSYISHFRRHSLSTRTWMDFLAAHLGQ------TVLQEVNWNEWLYGSGPIPWVPKSDRKLSSVVDQVVERIRS-TPLGSDTDSAAYVRCQYELMIPLQRQLLWQRL--LKYIPLSHDNLRVLDSMLAVSRSQNAEIRYRWSLIVLYSQYLPGVDCALEFLNSQGRMKFTRPIYKALMAWPTIRQQAINNFKSHRPFLHPTTAKLVEKDI 622          

Query:  262 DKTSYANSEDFIVDKSHFNWKLDFENEQISGSVVHNVKVLN---SASKELILDVRNLEIKRIVIDNEDVLFQYVNG---KLGGKLVIPLSLGTKRSKFQVIIEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSA---VRKSSTLSNDVRQHKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKMLRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSEN---ELLNKFSRMLPDQRYYFFQVLNDIQGVQLPESSLKVMGNIYGLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMHPIT 2064
            D +S +N E F+    +F+W +DF  + ISG V + +   +   +  + L+ DV++LEI ++ I+  +  +   +G   +LG  L I   L  + + F + I Y T+  S ALQW+   +T  K+  FL++Q QAI+ARSL+PCQDTP VK TY+AT+ A   + V+MSA      +   S+    H FEQ IP+PSYLV++ CG L  ++IGPRS V++EP + E+A  EF ++++++  AE +CGPY+W   D+L+LPPSFP+GGMENPC+ F+TP LL GD+S +  IAHE SHSWTGNLVTN++W++FW+NEGHT YLE L+LE +   + YR LHI LG  EL+  L  ++      H FTKLVP L G DPDD FS +PY+KGSLLL++LE   GK  ML+WL+ Y+  FR  S+ST  W  F  K      ++ P+ L  + WDDWFYK   IP   +     S +  C+ +V A I      S  N    + + +  ++  QR    Q L  ++ V  P  +L+V+  ++ ++   NSE+ + WSL+CLRS Y+P +    EFLNSQGR+K+ + +YK L  W     + + NF  Q+  MHP T
Sbjct:   19 DPSSNSNPEYFLTRHVNFDWTIDFNTKTISGCVAYEMVAFDLSTAPDQMLVFDVKDLEISKVCINETETKWLVTDGPHPQLGSCLKI--HLPEQTASFTLHIGYQTSPQSPALQWLDAAITADKQKPFLFTQCQAIHARSLFPCQDTPRVKFTYTATVRADPCMTVLMSAKYCADSTECPSSGNPVHNFEQPIPVPSYLVALVCGDLRSAQIGPRSKVWAEPSVVERAAFEFGEVDQVISAAERICGPYQWGNYDILVLPPSFPFGGMENPCLTFVTPTLLAGDRSLICTIAHEASHSWTGNLVTNASWENFWLNEGHTKYLEGLVLEAMYGVD-YRELHIELGYEELQACLADFK----QGHPFTKLVPCLDGVDPDDCFSIIPYQKGSLLLYFLEQKYGKPAMLKWLRAYLDHFRGLSLSTRSWLDFLSK------QLGPNVLTEVNWDDWFYKTDAIPWVPNFTRKLSTV--CDSVVSA-ITKEDLRSDANVADSVRSTYEGLVSLQRQLVLQRL--LERVPFPHDNLRVLDQMFQISQAKNSEIRYRWSLICLRSQYLPGLHSALEFLNSQGRMKFTRPIYKALMSWPSVAEQAISNFKAQRQNMHPTT 613          

Query:  262 DKTSYANSEDFIVDKSHFNWKLDFENEQISGSVVHNV---KVLNSASKELILDVRNLEIKRIVIDNEDVLFQYVNG---KLGGKLVIPLSLGTKRSKFQVIIEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSA-----VRKSSTLSNDVRQHKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKMLRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIP-----IEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLNKFSRMLPDQRYYFFQVLNDIQGVQLPESSLKVMGNIYGLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMHPIT 2064
            D +S +N E F+    +F+W LDF  + IS  V + +    +  +  + L+ DV++LEI ++ I+  +  +   +G   +LG  L I L   T  + F + IEY T+  S+ALQW+   MT  K+  FL++Q QAI+ARSL+PCQDTP VK TY+AT+ A   + V+MSA      R+  +  N V  H FEQ IP+PSYLV++ CG L  ++IGPRS V++EP +  KA  EF ++++++  AE LCGPY+W   D+++LPPSFPYGGMENPC+ F+TPCLL GD+S ++ IAHE+SHSWTGNLVTN++W++FW+NEGHT YLE L+LE +   + YR LHI LG  EL+  L  +       H FTKLVP L G   DD FS +PY+KGSLLL++LE   GK  ML+WL+ Y+  FR  S+ST  W  F  K      ++ P+ L  + W+DWFYK G IP         S + DS++    + V         P+  + + + +  ++P QR    Q L  ++ V +   +L+V+  +  ++ + NSEL + WSL+CLRS Y+P +    EFLNSQGR+K+ + +YK L        + + NF  Q+  MHP T
Sbjct:   19 DPSSNSNPEYFLTRHVNFDWTLDFNTKTISARVAYEMIPFDLYTAPDQMLVFDVKDLEISKVSINETETKWLVTDGPHPQLGSCLKIHLPRQT--TSFTLHIEYRTSPQSSALQWLDAAMTADKQKPFLFTQCQAIHARSLFPCQDTPRVKFTYTATVRADPCMTVLMSAKYFADPRECPSSGNPV--HNFEQSIPVPSYLVALVCGDLRSAQIGPRSKVWAEPSVVGKAAFEFGEVDQMISAAERLCGPYQWGTYDIVVLPPSFPYGGMENPCLTFVTPCLLAGDRSLISTIAHEVSHSWTGNLVTNASWENFWLNEGHTKYLEGLVLEAMYGFD-YRELHIELGYEELQACLAEFT----EGHPFTKLVPCLDGVHTDDYFSIIPYQKGSLLLYFLEQKYGKPAMLKWLQAYLDHFRGLSLSTRSWLDFLSK------QLGPNVLTEVNWNDWFYKTGAIPWVPKFTRKLSTVCDSVVSAITKEV-----LINDPNVASFVRSTYESLMPLQRQLVLQRL--LERVPIHHDNLRVLDQMLQISQSKNSELRYRWSLICLRSQYLPGLHSALEFLNSQGRMKFTRPIYKALMSCQSIAEQAINNFKAQRQNMHPTT 613          

Query:  259 NDKTSYANSEDFIVDKSHFNWKLDFENEQISGSVVHNVKVLNSASKELILDVRNLEIKRIVIDNEDVLFQY--VNGKLGGKLVIPLSLGTKRSKFQVIIEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVR--KSSTLSNDVRQ-HKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKMLRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLNKFS----RMLPDQRYYFFQVLNDIQGVQLPESSLKVMGNIYGLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMHPITRGEIHK 2082
             D  S+++    +    + + + DF +  + G V   V+VL      L LD ++L+I ++  + +   F+    +G  G  L I L          V +EY T+  ++ALQW+ P  T GKKH +L+SQ QA + R++ PCQDTP VK TY A +  P +L  VMSAVR  + +  ++  R  ++F Q +P+PSYL+++  G L   +IGPRS V+SE E  ++   EF + E +L  AE L GPY W   DLL+LPPSFPYGGMENPC+ F+TP LL GD+S  N IAHEISHSWTGNLVTN TW+HF                                         ++Q  +G ++  T LV NL G +PD+ FS VPYEKG  LL++LE L+G    + ++K+YI  F   SV+T++WK + F Y  +K  +    L  + W+ W Y PG  P + +   D ++   CN L + W        +++  L+ FS    + L   +   F  L  +Q   LP S +K M  +Y   +  NSE +  W  LC++S +  AV    +    QGR+K+ + L+  +Y++   +   V+ F   +  MH +T   + K
Sbjct:    5 TDHCSFSSFSKCLTRHLNLSLQADFSSRVLRGRVALTVEVLEDKFSSLTLDTKDLKIFKVSANGQAAKFELGAQHGFKGSPLDITLPFELSGQHVIVEVEYETSPSASALQWLSPAQTAGKKHPYLFSQCQATHCRTMVPCQDTPSVKHTYYAQVSVPKELIAVMSAVRDGQEADPTDSSRVIYRFRQPVPMPSYLIALVVGALESREIGPRSRVWSEKEHVDQGAFEFTETETMLKTAESLAGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDRSLSNVIAHEISHSWTGNLVTNKTWEHF-----------------------------------------VHQ--FGANNAATNLVVNLEGVNPDECFSCVPYEKGFALLYHLEELMGGPVFMGFVKSYIQMFAYSSVTTEQWKDYLFTYFKDKVDI----LNKVDWNGWMYTPGMPPFKPY---DTTLADACNALAQRWT------KAKDADLSGFSEADIKQLSSHQLIEFLALLLLQD-PLPTSHVKRMQEVYKFNSINNSE-IRCWLRLCVKSEWEDAVPLALKMATEQGRMKFTRPLFD-VYNFAKFRDEAVKVFKEHRNEMHSVTAMLVAK 562          

Query:  259 NDKTSYANSEDFIVDKSHFNWKLDFENEQISGSVVHNVKVLNSASKELILDVRNLEIKRIVIDNEDVLFQY--VNGKLGGKLVIPLSLGTKRSKFQVI-IEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSNDVRQHKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKM-LRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLNKFS----RMLPDQRYYFFQVLNDIQGVQLPESSLKVMGNIYGLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMHPIT 2064
             D  S+++    +    + + + DF +  + G V   V+VL      L LD ++L+I ++  + +   F+    +G  G  L I L     R +  ++ +EY T+  ++ALQW+ P  T GKKH +L+SQ QA + R++ P   T             P+D   V+               ++F Q +P+PSYL+++  G L   +IGPRS V+SE E  ++   EF + E +L  AE L GPY W   DLL+LPPSFPYGGMENPC+ F+TP LL    +    IAHEISHSWTGNLVTN TW+HFW+NEGHT YLER+I    Q                           +G ++  T LV NL G +PD+ FS VPYEKG  LL++LE L+G  ++ + ++K+YI  F   SV+T++WK + F Y  +K  +    L  + W+ W Y PG  P +     D ++   CN L + W        +++  L+ FS    + L   +   F  L  +Q   LP S +K M  +Y   +  NSE+   W  LC++S +  AV    +    QGR+K+ + L++ +Y++   +   V+ F   +  MH +T
Sbjct:    5 TDHCSFSSFSKCLTRHLNLSLQADFSSRVLRGRVALTVEVLEDKFSSLTLDTKDLKIFKVSANGQAAKFELGAQHGFKGSPLDITLPFELSRGQHVIVEVEYETSPSASALQWLSPAQTAGKKHPYLFSQCQATHCRTMVPNLLTQTHIAVRDGQEADPTDSSRVI---------------YRFRQPVPMPSYLIALVVGALESREIGPRSRVWSEKEHVDQGAFEFTETETMLKTAESLAGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLVSTCNSPGVIAHEISHSWTGNLVTNKTWEHFWLNEGHTVYLERMIGRVHQ---------------------------FGANNAATNLVVNLEGVNPDECFSCVPYEKGFALLYHLEELMGGPEVFMGFVKSYIQMFAYSSVTTEQWKDYLFTYFKDKVDI----LNKVDWNGWMYTPGMPPFKPQ--YDTTLADACNALAQRWT------KAKDADLSGFSEADIKQLSSHQLIEFLALLLLQVDPLPTSHVKRMQEVYKFNSINNSEIRCRWLRLCVKSEWEDAVPLALKMATEQGRMKFTRPLFRDVYNFAKFRDEAVKVFKEHRNEMHSVT 560          

Query:  259 NDKTSYANSEDFIVDKSHFNWKLDFENEQISGSVVHNVKVLNSASKELILDVRNLEIKRIVIDNEDVLFQY--VNGKLGGKLVIPLSLGTKR-----SKFQVIIE--YNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSNDVRQHKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKM-LRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLNKFS----RMLPDQRYYFFQVLNDIQGVQLPESSLKVMGNIYGLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMHPIT 2064
             D  S+++    +    + + + DF +  + G V   V+VL      L LD ++L+I ++  + +   F+    +G  G  L I L     R     S   VI+E  Y T+  ++ALQW+ P  T GKKH +L+SQ QA + R++ P   T             P+D   V+               ++F Q +P+PSYL+++  G L   +IGPRS V+SE E  ++   EF + E +L  AE L GPY W   DLL+LPPSFPYGGMENPC+ F+TP LL         IAHEISHSWTGNLVTN TW+HFW+NEGHT YLER+I    Q                           +G ++  T LV NL G +PD+ FS VPYEKG  LL++LE L+G  ++ + ++K+YI  F   SV+T++WK + F Y  +K  +    L  + W+ W Y PG  P +     D ++   CN L + W        +++  L+ FS    + L   +   F  L  +Q   LP S +K M  +Y   +  NSE+   W  LC++S +  AV    +    QGR+K+ + L++ +Y++   +   V+ F   +  MH +T
Sbjct:    5 TDHCSFSSFSKCLTRHLNLSLQADFSSRVLRGRVALTVEVLEDKFSSLTLDTKDLKIFKVSANGQAAKFELGAQHGFKGSPLDITLPFELSRLCIFISGQHVIVEVEYETSPSASALQWLSPAQTAGKKHPYLFSQCQATHCRTMVPNLLTQTHIAVRDGQEADPTDSSRVI---------------YRFRQPVPMPSYLIALVVGALESREIGPRSRVWSEKEHVDQGAFEFTETETMLKTAESLAGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLV--------IAHEISHSWTGNLVTNKTWEHFWLNEGHTVYLERMIGRVHQ---------------------------FGANNAATNLVVNLEGVNPDECFSCVPYEKGFALLYHLEELMGGPEVFMGFVKSYIQMFAYSSVTTEQWKDYLFTYFKDKVDI----LNKVDWNGWMYTPGMPPFKPQ--YDTTLADACNALAQRWT------KAKDADLSGFSEADIKQLSSHQLIEFLALLLLQVDPLPTSHVKRMQEVYKFNSINNSEIRCRWLRLCVKSEWEDAVPLALKMATEQGRMKFTRPLFRDVYNFAKFRDEAVKVFKEHRNEMHSVT 558          

Query:  253 SQNDKTSYANSEDFIVDKSHFNWKLDFENEQISGSVVHNVKVLNSASKELILDVR-NLEIKRIVI--DNEDVLFQYVNGK----LGGKLVIPLSLG-TKRSKFQVIIEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSNDVRQHKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFED-IEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLH-GKDPDDSFSRVPYEKGSLLLFYLETLIGKDKML-RWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPG-PIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLNKFSRMLPD-----QRYYFFQVLNDIQGVQLPESSLKVMGNIYG-LTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDW-DDTKSRTVENFHIQKFAMHPITRGEIHKII 2088
            +  D  + ++   F ++  H + ++DF+   +SG+    V+    ++ EL+LD   +LE+  +    D  D      + +     G  LV+      +   +F + I+Y T +    + W+ PE T GK   ++++Q QA+  RS +PC DTP VK+TY+A I+ P     VMSA +     +++      EQ  PIP+YLV++A G LV +++GPRS V++EP L E A+ E++  IE+ L++ E L GPY W   D+L +PPSFP+GGMENPC+ F+TPCLL GD+S  + I HEI HSW GNLVTN+ W  FW+NEG T Y +R I ++L   E Y  L    G + L   ++      G DH   KL   +  G DPDD+++  PYEKG   + YL  L G  K    +LK Y+  F+ +SV  ++   FF ++  + +K    K+EG+++D W    G P+ +   S    S+++  ++L   W        +++  +   S++  +     Q  YF   +  I+   LP+ + +++   Y  +  + N+EL   W+ +  ++ + P    V  FL+ QG+ KY   +Y+ L+   ++ K+   E F      +H   R  + KI+
Sbjct:   12 TAEDVATSSSFRRFRIEHFHLDLQVDFDQRSLSGTESLRVRCALGSAAELLLDSHPSLELHEVSFSRDERDWTAAQFHSRDFTSYGSTLVVQFPTAWSSGDQFHLSIKY-TAHQGPGVCWLDPEQTAGKLRPYVFTQGQAVLNRSFFPCFDTPAVKSTYTAAIKVPDGFTAVMSATKWEHRKADNTFLFSMEQ--PIPAYLVALAVGDLVSAEVGPRSRVWTEPCLLEAAKKEYDGVIEEFLLVGERLFGPYVWGRYDVLFMPPSFPFGGMENPCLTFVTPCLLAGDRSLADVIIHEICHSWFGNLVTNANWGDFWLNEGFTMYAQRRICKELY-GEAYTCLEAATGRALLRQHMDN----TGEDHPLNKLRVKIKPGVDPDDTYNETPYEKGFCFVSYLAHLRGDQKRFDAFLKAYVDRFKFRSVIAEDALEFFLEFFPDLKKNSVHKIEGLEFDSWLNVSGWPLYLPDLS-AGQSLMKPADQLADLW-------GADSVDIAAISKINTEAWKTYQTVYFLDKI--IEKSPLPDGNTRMLEEQYPHMVKSNNAELRLRWAQIVAKNQHKPGYPHVRSFLSCQGKQKYTLPVYRALWSGTEEMKALATEIFSATSHQLHINVRNYVKKIM 624          

Query:  253 SQNDKTSYANSEDFIVDKSHFNWKLDFENEQISGSVVHNVKVLNSASKELILDVR-NLEIKRIVI--DNEDVLFQYVNGK----LGGKLVIPLSLG-TKRSKFQVIIEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSNDVRQHKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFED-IEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLH-GKDPDDSFSRVPYEKGSLLLFYLETLIGKDKML-RWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPG-PIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLNKFSRMLPD-----QRYYFFQVLNDIQGVQLPESSLKVMGNIYG-LTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYN 1968
            +  D  + ++   F ++  H + ++DF+   +SG+    V+    ++ EL+LD   +LE+  +    D  D      + +     G  LV+      +   +F + I+Y T +    + W+ PE T GK   ++++Q QA+  RS +PC DTP VK+TY+A I+ P     VMSA +     +++      EQ  PIP+YLV++A G LV +++GPRS V++EP L E A+ E++  IE+ L++ E L GPY W   D+L +PPSFP+GGMENPC+ F+TPCLL GD+S  + I HEI HSW GNLVTN+ W  FW+NEG T Y +R I ++L   E Y  L    G + L   ++      G DH   KL   +  G DPDD+++  PYEKG   + YL  L G  K    +LK Y+  F+ +SV  ++   FF ++  + +K    K+EG+++D W    G P+ +   S    S+++  ++L   W        +++  +   S++  +     Q  YF   +  I+   LP+ + +++   Y  +  + N+EL   W+ +  ++ + P    V  FL+ Q R  ++
Sbjct:   12 TAEDVATSSSFRRFRIEHFHLDLQVDFDQRSLSGTESLRVRCALGSAAELLLDSHPSLELHEVSFSRDERDWTAAQFHSRDFTSYGSTLVVQFPTAWSSGDQFHLSIKY-TAHQGPGVCWLDPEQTAGKLRPYVFTQGQAVLNRSFFPCFDTPAVKSTYTAAIKVPDGFTAVMSATKWEHRKADNTFLFSMEQ--PIPAYLVALAVGDLVSAEVGPRSRVWTEPCLLEAAKKEYDGVIEEFLLVGERLFGPYVWGRYDVLFMPPSFPFGGMENPCLTFVTPCLLAGDRSLADVIIHEICHSWFGNLVTNANWGDFWLNEGFTMYAQRRICKELY-GEAYTCLEAATGRALLRQHMDN----TGEDHPLNKLRVKIKPGVDPDDTYNETPYEKGFCFVSYLAHLRGDQKRFDAFLKAYVDRFKFRSVIAEDALEFFLEFFPDLKKNSVHKIEGLEFDSWLNVSGWPLYLPDLS-AGQSLMKPADQLADLW-------GADSVDIAAISKINTEAWKTYQTVYFLDKI--IEKSPLPDGNTRMLEEQYPHMVKSNNAELRLRWAQIVAKNQHKPGYPHVRSFLSCQVRRHFS 583          

Query:  643 QAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSS---TLSNDVRQHKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFW 1173
            QAI+ RS+ PCQDTP +K TY A +  P  L  +MSA+   S     + +   HKF+Q + IPSYL+++  G L   +IGPR+ V+SE E  E+A  EF + E +L  AEEL GPY W   DLL+LPPSFPYGGMENPC+ F+TP +L GDKS    +AHEISHSWTGNLVTN TW+HFW
Sbjct:    1 QAIHCRSMVPCQDTPSLKFTYDAKVSVPKSLVALMSALCDGSEPDPTNGEFTVHKFKQPVQIPSYLIALVVGALKSREIGPRTKVWSEKEFVEQAASEFSETETMLTTAEELVGPYVWGRYDLLVLPPSFPYGGMENPCLTFVTPTVLAGDKSLAGVVAHEISHSWTGNLVTNKTWEHFW 180          

Query: 1309 YGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLE-TLIGKDKMLRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFH--QFPSSENELLNKFSRMLPDQRYYFFQVLNDIQGVQLPESSLKVMGNIYGLTNTTNSEL 1869
            +GP+H FTKLVP L G DPDDSFS VPYEKG  LL++LE  L G D  + ++K YI  F   + +T+EWK + F+Y  +K  V    L+ + W  W Y PG  P++     D ++  +C+ L   W         S   + L  FS    +Q+  F  +L     + +   SL+ M  +Y L +  NSE+
Sbjct:    4 FGPEHGFTKLVPVLDGVDPDDSFSTVPYEKGFALLYHLEQALGGPDVFIGFVKAYIEKFAYSTATTEEWKAYLFEYFKDKADV----LQAVDWKAWIYSPGMPPVKLQ--YDTTLADDCSALATRWSQAKDADLASFSADDLKDFSS---NQKVEFLALLLLQPALPV--KSLQRMEEVYKLNSVKNSEI 182          

Query:  463 FQYVNGKLGGKLVIPLSL--GTKRSKFQVIIEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAV----RKSSTLSNDVRQHKFEQKIPIPSYLVSIACGHL----VGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCG-PYEWEICDLLILPPSFPYGGMEN-PCIIFLTPCLLTGDKSQLN--------YIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKL-------VPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKMLRWLKTYIAAFRLKSVSTDE-WKTF 1521
            F Y N      L  P +L  G+   K + + E N  +        K     G+      +Q +A +AR  +PC D P +K T+  T+  P D  V +S +    RK      ++ + ++ +   + +YL++   G        S  G    VY+    +E+ +   E   K L   ++    PY     DL+ +   F  G MEN   + +    LL   K+  +         + HE++H W GNLVT   W H W+NEG  +++E L ++           H +    E +         Y P  E   L       VP  H  + D+ F  + Y KG+ ++  L   IG +   + +  Y+  F+ K+ +T++ W++ 
Sbjct:   76 FNYQNEDEKVALSFPSTLEPGSGMLKIEFVGELN--DKMKGFYRSKYTAACGEARYAAVTQFEATDARRAFPCWDEPGIKATFDVTLIVPQD-RVALSNMNVLERKPHEADPELVEVRYARTPIMSTYLLAFVVGEFDFVEARSSDGVLVRVYTPLGKSEQGKFALEVATKTLPFYKDYFNVPYPLPKIDLIAIA-DFAAGAMENWGLVTYRETALLVDPKNSSSASKQWVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVD-----------HCF---PEFDIWTQFVSTDYAPALELDALDNSHPIEVPVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDEDFKKGMNMYLTKFQHKNAATEDLWESL 438          

Query:  634 SQSQAINARSLYPCQDTPFVKTTYSATI------EAPSDLEVVMSAVRKSSTLSNDVRQHKFEQKIPIPSYLVSIACGHL-----VGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCG-PYEWEICDLLILPPSFPYGGMEN-PCIIFLTPCLL-------TGDK-SQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDP--------------DDSFSRVPYEKGSLLLFYLETLIGKDKMLRWLKTYIAAFRL-KSVSTDEWK 1515
            SQ +  +AR  +PC D P +K T+  T+       A S++ VV   +  ++++  D    KF   + +P+YL++           V +K   R            A        KIL   EE    PY     D + +P  F  G MEN   + +    LL        G+K S    + HE++H W GNLVT   W   W+NEG  +YLE                  Y+G  E+E   N+  +I   D +    V  L    P              +  F  + Y KG+ +L    + + +   +  LK+Y+   +   +V  D W+
Sbjct:  210 SQMEPTDARKTFPCFDEPDMKATFDITLIHKAEHVALSNMPVVY--MSTATSIEEDWVHTKFNTSVVMPTYLLAFIISDFEKVEAVANKTLIRIWAKKTEIAAGNAEYALNITGKILNFFEEYYDVPYVLPKSDQIAIP-DFAAGAMENWGLVTYRETALLYNPDVSSNGNKESVATIVTHELAHQWFGNLVTMRWWSELWLNEGFASYLE------------------YIGTHEVEPSWNIKALIILNDLQRAMSVDALASSRPLSVPHSEVMTPAQANSMFDTISYSKGACILSMTSSFLTEPVFVAGLKSYLKEMQFGNAVHQDLWR 518          

Query:  610 GKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATI-EAPSDLEVVMSAVRKSSTLSNDVRQHKFEQKIPIPSYLVSIACGHLVG----SKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCG-PYEWEICDLLILPPSFPYGGMEN-PCIIFLTPCLLTGDKSQ--------LNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKMLRWLKTYIAAFRLKSVSTDE-WKTF 1521
            G       +Q +  +AR  +PC D P  K ++  +I    +   +    + ++ T  + + +  F+  + + +YLV+            +K G   ++Y+ P   ++     E+  K L   EEL    Y     DL+ +P  F  G MEN   + +    LL G K+            IAHE++H W GNLVT + W+  W+NEG   ++E +    L+    +  + ++L    +E    + Q      H  +     +      + F  V Y KG+ +L  L T +     +  ++ Y+      +  TD+ W++ 
Sbjct:  324 GSDRPLAVTQFEPTSARESFPCFDEPDFKASFDISIVRDAAHTTLSNMPLNETVTRKDGLLEDTFKGSVVMSTYLVAFIVSDFKSISNKTKHGTNVSIYTSPGKEQQGSFALENAIKFLDFYEELFNISYPLPKQDLVAIP-DFAAGAMENWGLVTYRETALLLGPKASGVRDTLWVAQVIAHELAHQWFGNLVTMNWWNDLWLNEGFATFMEFVATGSLKPD--WLMMDVFLTEVVMEA---LTQDSLPSSHAISSAA--VGTMQIGEMFDSVSYNKGASVLNMLRTFLTPAVFVDGIRDYLLVHSYGNAHTDDLWESL 635          

Query:  262 DKTSYANSEDFIVDKSHFNWKLDFENEQISGSVVHNVKVLNSA---SKELILDVRNLEIKRIVIDNEDVLFQYVNGK--LGGKLVIPLSLGTKRSKFQVIIEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSNDVRQHKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFE-DIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLH-GKDPDDSFSRVPYEKGSLLLFYLETLI-GKDKMLRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHH-SLLDDSMIQECNELVKAWIGFHQFPSSENELLNKFSRM-----LPDQRYYFFQVLN----------DIQGVQLPESSLKVMGNIY--GLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMHPITRGEIHK 2082
            D+++ +N +DF V  +  N  + FE   ISGSV   +K L+     S EL LD   L+++ + ID     FQ    K  LG +LVI  +  +    F + I++ TT+  TALQW+  + T G K  +++SQ +AI+ARSL+PC DTP VK+T++A+IE+P  L VV S +R   T S D   ++FEQK+PIP+YL+ IA G L  + IGPRSTVY+EP   +  + EFE D+EK +  AE++   YEW   D+L+   S+PYGGME+P + F TP L+  D+S ++ IAHE++HSW+GNLVTN +W+HFW+NEG T YLER I+  +   EP RH    +G S+L+  ++  +    P+  F+ LV NL+   DPDD+FS VPYEKG  LLF+LET++ GK +   +++ Y   F  KS+ T ++    +++  EK+++    L+ + W+ W YKPG  P  H  + L D++ Q    L   W+   Q   +  +  ++F+ +       +Q   F + L           D    + P +S + + +IY   +  + N+E++       + +        + ++L + GR+K+ +  Y+ L   D  +   +  F   K   HPI +  + +
Sbjct:   57 DQSTLSNYKDFAVLHTDLNLSVSFEKSAISGSVTFQLKKLHEGKNKSDELHLDTSYLDVQEVHIDGSKADFQIEQRKEPLGSRLVI--NNASCNDNFTLNIQFRTTDKCTALQWLNSKQTKGGK-PYVFSQLEAIHARSLFPCFDTPSVKSTFTASIESP--LPVVFSGIRIEDT-SKDTNIYRFEQKVPIPAYLIGIASGDLSSAPIGPRSTVYTEPFRLKDCQWEFENDVEKFIQTAEKIIFEYEWGTYDILVNVDSYPYGGMESPNMTFATPTLIAHDRSNIDVIAHELAHSWSGNLVTNCSWNHFWLNEGWTVYLERRIIGAIH-GEPTRHFSALIGWSDLQNSIDSMK---DPE-RFSTLVQNLNDNTDPDDAFSTVPYEKGFNLLFHLETILGGKAEFDPFIRHYFKKFAKKSLDTFQFLDTLYEFYPEKKEI----LDSVDWETWLYKPGMPPRPHFITALADNVYQ----LADKWVEMAQHLKTTEDFRSEFNAIDIKDFNSNQLVLFLETLTQNGHSNKKPKDFDWAKFPVAS-RALLDIYQDNIVKSQNAEVVFKMFKFQIFAKLQEEYKHLADWLGTVGRMKFVRPGYRLLNSVD--RRLALATFDKFKDTYHPICKALVKQ 667          

Query:  610 GKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSNDVRQHKFEQKIPIPSYLVSIACGHL--VGS---KIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCG-PYEWEICDLLILPPSFPYGGMENPCIIF--LTPCLLTGDKSQLN-------YIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKMLRWLKTYIAAFRLKSVST-DEW 1512
            G+      +Q +A +AR  +PC D P +K T++ T+ + S L  + +   ++ T+    +   F     + +YLV+     L  V S   +I  R  VYS P   +  +       + L   E+     Y     D++ +   F  G MEN  ++   +   LL  + S L+        I HE++H W GNLVT   W+  W+NEG   ++      K Q        ++      L+  LN+  +      E    VP  +  + +  F  + Y KGS LL  +   +G++  ++ +  Y+  F+  +  T D W
Sbjct:  121 GETKYMATTQMEATDARRAFPCFDEPNLKATFAVTLVSESFLTHLSNMDVRNETIKEGKKYTTFNTTPKMSTYLVAFIVADLRYVESNNFRIPVR--VYSTPGDEKFGQFAANLAARTLRFFEDTFNIEYPLPKMDMVAVH-EFSAGAMENWGLVTYRVIDLLLDIENSSLDRIQRVAEVIQHELAHQWFGNLVTMDWWEGLWLNEGFATWMSWYSCNKFQPEWKVWEQYV---TDNLQRALNLDSLRSSHPIE----VPVNNADEINQIFDAISYSKGSSLLRMISKWLGEETFIKGVSQYLNKFKYGNAKTGDLW 427          

Query:  610 GKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSNDVRQHKFEQKIPIPSYLVSIACGHL--VGSK---IGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCG-PYEWEICDLLILPPSFPYGGMENPCIIF--LTPCLLTGDKSQLNYIA-------HEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKMLRWLKTYIAAFRLKSVSTDE 1509
            G+      +Q +  +AR  +PC D P +K +++ T+ +   L  + +   K+  + +  +   F     + +YLV+     L  V SK   I  R  VY+ P   +  +   +   K L   E+  G  Y     D + +   F  G MEN  ++   +   LL  D S L+ I        HE++H W GNLVT   W+  W+NEG   ++      + Q        ++      L+  L++  +      E    VP     + +  F  + Y KG+ LL  +   +G++  ++ +  Y+  F+  +  T++
Sbjct:  217 GETKYMATTQMEPTDARRAFPCFDEPNLKASFAITLVSDPSLTHLSNMDVKNEYVKDGKKVTLFNTTPKMSTYLVAFIVAELKYVESKNFRIPVR--VYATPGNEKHGQFAADLTAKTLAFFEKTFGIQYPLPKMDNVAVH-EFSAGAMENWGLVTYRVVDLLLDKDNSTLDRIQRVAEVVQHELAHQWFGNLVTMDWWEGLWLNEGFATWMSWYSCNEFQPEWKVWEQYV---TDTLQHALSLDSLRSSHPIE----VPVKKADEINQIFDAISYSKGASLLRMISKWLGEETFIKGVSQYLNKFKYGNAKTED 521          

Query:  634 SQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSNDVRQH--KFEQKIPIPSYLVSIACGHLVGSKI-----GPRS---TVYSEPELNEKARLEFEDIEKILVIAEE-LCGPYEWEICDLLILPPSFPYGGMENPCII-------FLTPCLLTGD---KSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEK------LQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDP--DDSFSRVPYEKGSLLLFYLETLIGKDKMLRWLKT 1467
            +  Q  +A +++PC D P  K+T+   I   +  + V +   +     +  ++H  KF +   + + +   + G L   K      G R+   ++Y+  ++   A    + ++K L + E     PY     D ++LP       MEN  +I        + P  L  +   +     I HE+ H W GN ++  +W+  W NE    +L   ILE+        +SEPY    +   +     D+N   I         ++     G D    D F    Y KG ++L  L+   G+  + + L++
Sbjct:  152 THCQPFSASNIFPCIDEPSNKSTFQLNIATDAQYKAVSNTPVEMVEALDSSQKHLVKFAKTPLMTTSVFGFSIGDLEFLKTEIKLEGDRTIPVSIYAPWDI-ANAAFTLDTVQKYLPLLESYFKCPYPLPKLDFVLLP-YLSDMAMENFGMITIQLNHLLIPPNALANETVREQAQQLIVHELVHQWMGNYISFDSWESLWFNESFATWLACHILEQNGDLSHYWTSEPYLLQQVEPTMCRDAADVNGRSIF--------QIAQRNTGIDSQTSDIFDPEAYTKGIIMLRSLQLATGESHLQKGLES 448          

Query:  259 NDKTSYANSEDFIVDKSHFNWKLDFENEQISGSVVHNVKVLNSASKELILDVRNLEIKRIVI--DNEDVLFQYVNG--KLGGKLVIPLSLGTKR-SKFQVIIEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSN---DVRQHKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKMLR-WLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLNKFSRM------LPDQRYYFFQVLNDIQGVQLPESSLKVMGNIYGLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMHPITRGEIHK 2082
            +D  S++  E+ +     +N  +DF ++ +   V  +  V       L+LD R+L ++ + +   N+ + F   +     G  L I L  G K  ++  + I Y T+ D++ALQW+ PE T GKKH ++++Q QAI+ARS+ PCQD+P VK TYSA +  P DL  +MSA R  S L +   D+  ++FEQK+ IPSYL+++  G L G ++GPRS V++E E+ E+   EF ++E+++  AE L G Y W   DLLILPPSFPYGGMENPC+ F+TP LL GD+S    IAHEISHSWTGNLVTNSTW+HFW+NEG T +LER I+ +++  E  R      G   L   ++     +  +   TKLV +L   DPDD+FS VPYEKGS  L YLE L+G  ++   + + YI  ++ K+ +TDEWKTF F Y  +K  +    LE + W+ W  KPG  P+      D S+   C  L + WI      +SE E LN FS         P +  +  Q+L       L  + L+ M N Y   +  NSE+   W  LC+RS +  A     +FL SQGR+K+ + LY+ L+  + +K   V  F   +   HPI    + K
Sbjct:    2 SDPCSFSRPEECLCTNITWNVSVDFASKVLVCDVELDFLVKKDNVASLVLDTRDLNVQSVAVRPSNDQLTFSLGSKHKAFGTPLEISLPPGLKSGARLSIAISYRTSPDASALQWLTPEQTSGKKHPYMFTQCQAIHARSIIPCQDSPGVKATYSAKVSVPKDLVALMSAARTGSELDHQKQDLMTYQFEQKVAIPSYLIALVVGALKGRQVGPRSHVWTEQEMVEECAYEFAEMEQMISAAESLVGEYVWGPYDLLILPPSFPYGGMENPCLTFVTPTLLAGDRSLTGVIAHEISHSWTGNLVTNSTWEHFWLNEGFTVFLERKIIGRMK-GEQMRQFGFIGGWKTLMDAVSK----FADNMSLTKLVVSLKDTDPDDAFSSVPYEKGSCFLVYLEQLLGGPEVFEPFFRKYIDTYKYKTCTTDEWKTFLFDYFKDKTNI----LETVDWEAWLRKPGMPPVNMIERYDSSLADACISLCQKWIN-----ASEKE-LNSFSSQDIASFTSPQKVEFLAQLLAKTSSSPLSVAHLQAMQNAYQFNSYKNSEIKFRWLRLCVRSGWADAFQPTVDFLLSQGRMKFTRPLYEELFKCEKSKDLAVTTFKKHRAFYHPICSAMVAK 609          

Query:  541 VIIEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSA--VRKSSTLSNDVRQHKFEQKIPIPSYLVSIACGH---------LVGSKIGPRSTVYSE----PELNEKARLEFED-IEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEP------------YRHLHIYLGISEL--EGDLNMY----QIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKMLRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQF------PSSENELLNKFSRMLPD------QRYYFFQVLNDIQGVQLPESSLKVMGNIYGLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFL 1941
            V+I+Y+T+ +  +L W     T       ++S    IN RSL PCQ+ P   +T+ A I  P     +MS   V   +T ++  +       +P+P   +++A G+         +  +K GP   V       P + ++A  E    +   +  + EL GPY +   DLLILP  F   G++NP ++FL+  +L GD S    +AHEISH+W G L+    W   W++EG + Y+E  I  + +   P             R L  Y  +S    E D N+     +    P+ E        +G+     +++V Y KG  LL ++  ++G +   R+L  Y+  ++ + V++++    FF+Y + K       ++   + +W   PG +P     L       + N L+ A +   +F       +  N+ +N   R  P+             +   ++   L  ++L+ +   Y  + T N E+ H W  L +++ + P +D V  FL
Sbjct:   19 VVIKYHTSPEGQSLSWA----TDQDGRPCVFSPGAYINNRSLMPCQEPPIAMSTWQAAIHVPHGCMALMSGNPVTMETTATDTDKGRYCTMDVPLPCSTLAMAVGYFESMEGRSAICPTKDGPAEPVECRMIAVPSIIDRASDELLSYVPGFIEASCELLGPYPFSRLDLLILPKCFACMGLKNPNLVFLSQSVLAGDGSIRVRVAHEISHAWFGLLIGAKDWTEEWLSEGFSTYIEERIQARAEKVNPGCAKKKNNSLRELRQLLRYRALSAEMDETDENLQCLRSRASLSPNEEAKPFTVVKNGQICSKKWTQVHYLKGYFLLHHMAAMVGLENFERFLYEYVQHYQGQLVTSED----FFQYFVCKFPNVSQSVKDEFFLEWLESPG-LP---KCLRSKKFNVKENALIAAALKQFEFWRKQDNINKRNKTMNIKRRKQPEAEPLEHSEQIVLMLEKLVERDALMHTTLRQLNRCYNFS-TRNCEIRHRWCELVVKNKFTPFLDDVKHFL 518          

Query: 1309 YGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKMLR-WLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLNKFS 1737
            +  +   TKLV +L   DPDD+FS VPYEKGS  L YLE L+G  ++   + + YI  ++ K+ +TDEWKTF F Y  +K  +    LE + W+ W  KPG  P+      D S+   C  L + WI      +SE E LN FS
Sbjct:    4 FADNMSLTKLVVSLKDTDPDDAFSSVPYEKGSCFLVYLEQLLGGPEVFEPFFRKYIDTYKYKTCTTDEWKTFLFDYFKDKTNI----LETVDWEAWLRKPGMPPVNMIERYDSSLADACISLCQKWIN-----ASEKE-LNSFS 137          

Query:  298 VDKSHFNWKLDFENEQISGS---VVHNVKVLNSASKELILDVRNLEIKRIVIDNEDVLFQYVNGKLGGKLVIPLSLGTKRSKFQVIIEYNTTNDSTALQWMKPEMTM--GKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSNDVRQHKFEQKIPIPSYLVSIACGHL----VGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCG-PYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQ--------LNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKMLRWLKTYIAAFRLKSVSTDE-WKTF 1521
            +D+ HF+ K+D        +   +VHN +          L+V +++I++        + Q+   K     V+      + S + V I Y          + +   T   G++  F+ +Q + + AR  +PC D P +K T++ TI    D   + +     S + +  R   FEQ + + +YLV+   G        ++   +  VYS  E  +           +L + ++     Y     D++ LP   P G MEN  +I      L  +K             IAHE++H W GN+VT + WD  W+NE    +   +  +   ++EP  H+  +  +  +E  + +  +     H     VP +   +  + F  + Y KG+ +L  LE +IG D  +  L+ Y+      + +TD+ W++F
Sbjct:   45 LDRDHFHGKVDIYINVFKATKIIIVHNRR----------LNVSDIDIRKTGSQGSLGIRQHFPFKKNQFYVMEAEQSLEPSLYVVSISYKGFYSKGLRGFYRSSFTQNNGQRVYFVATQFEPVKAREAFPCFDEPGMKATFNITIAHRPDYVALSNMPIYQSKIIDGQRHDYFEQSVVMSTYLVAFTVGDFYYKETVTENNVKMRVYSRREALDTTEYAIRVGRDVLKLFDQYYDMGYSLTKLDMIGLPEFGP-GAMENWGLIKYRESYLLWNKESSEDAKYNVARIIAHELAHQWFGNIVTMAWWDDLWLNEA---FATLMAYKGADAAEPSWHVDQHFLVDTVEVAMTLDGL--ASSHPIR--VPVISPDEIGEIFDAISYSKGATVLRMLEYIIGNDTFIDGLRRYLKTHAYGNANTDDLWESF 453          

Query:  610 GKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIE-APSDLEVVMSAVRKSSTLSNDVRQHKFEQKIPIPSYLVS-IACGHLVGSKIGPRSTV---YSEPELNEKARLEFEDIEKILVIAEELCG-PYEWEICDLLILPPSFPYGGMENPCIIFL--TPCLLTGDKSQLNY-------IAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKMLRWLKTYIAAFRLKSVSTDE-WKTF 1521
            GK  +   +Q Q  +AR  +PC D P +K T++ TIE  P  + +    + K+ T +     H FE+ + +P+YL++ + C   V      R  +   Y+ P+  E+         KIL   E      Y     D++ +P  F  G MEN  ++    T  L     S  +Y       IAHE++H W GNLVT   WD  W+NEG  +++E   + K+   EP   +     I++ +   ++  ++    H   K+  N H  + ++ F  + Y KGS +L  LE  +G++K  + L  Y+      +  TD+ WK  
Sbjct:  207 GKNVTIATTQFQPTDARKAFPCLDEPALKATFNITIEHRPDFIAISNMPIWKNETRNGRTVDH-FEKTVVMPTYLLAMVVCDFGVKETKSARGVMMRYYAPPDKVEQLNYAASIGNKILDDFEHYYNISYPLPKADMIAIP-DFAAGAMENWGLMTYRETALLWKEGTSSESYKQRVAAVIAHELAHQWFGNLVTMEWWDDLWLNEGFASFVEYKGVNKV---EPTWGMDDQFVITDSDTAFSLDGLV--SSHPI-KVAVN-HPAEINEIFDSISYNKGSCILRMLEDFLGENKFKKGLTRYLKRHAYGNAETDDLWKAL 517          

Query:  259 NDKTSYANSEDFIVDKSHFNWKLDFENEQISGSVVHNVKVLNSASKELILDVRNLEIKRIVIDNEDVLFQYVNGKL--GGKLVIPLSLGTKRSKFQVI-IEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSNDVRQ---HKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKM-LRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLNKFSR-----MLPDQRYYFFQVLNDIQGVQLPESSLKVMGNIYGLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMHPITRGEIHK 2082
            +D  S+++    +    + + ++DF    I+G+V   V+ L      L LD R+L +  +  + +   F   +     G +L I L     R +  ++ + Y T+  ++ALQW+ PE T GKK  +L+SQ QA + RS+ PCQDTP VK TY A +  P DL  VMSAVR       +      ++F Q +P+PSYL++I  G L   +IGPRS V+SE E  +KA  EF + E +L  AE+L GPY W   D+L+LPPSFPYGGMENPC+ F TP LL GDKS    IAHEISHSWTGNLVTN TW+HFW+NEGHT YLER+I  ++   E +R      G  +L+  +N     +GP++  T LVP+L   DPDD+FS VPYEKG  LL++LE L+G  ++ + ++K+YI  +   SV+TD+WK + F Y   K++ E   L  + W+ W + PG  P++     D ++   C  L + W        + ++ L+ FS      +   Q   F  +L  +    LP + +K M  +YGL   TNSE+   W  LC+RS +  AV    +    QGR+K+ + L++ +++++  +   V+ F   + AMHP+T G + K
Sbjct:    2 SDPCSFSSPSRCVTKHLNLHLRVDFRRRVIAGTVELTVEALEDNFSLLTLDTRDLNVVSVSANQQPARFTLASKHSFKGTQLDITLPFHLSRGQHVIVQVVYETSPSASALQWLTPEQTAGKKQPYLFSQCQAHHCRSMVPCQDTPSVKHTYYAQVSVPKDLVAVMSAVRDGQEEDPEDSSRIVYRFRQPVPMPSYLIAIVVGALESREIGPRSRVWSEKEFVDKAAFEFSETETMLKTAEDLAGPYVWGQYDILVLPPSFPYGGMENPCLTFATPTLLAGDKSLSTVIAHEISHSWTGNLVTNKTWEHFWLNEGHTVYLERMIGRQMY-GEQFRQFKAMGGWKDLQDSVN----TFGPNNPLTNLVPSLQDVDPDDAFSSVPYEKGFALLYHLEELMGGPEVFMGFVKSYIQLYAYGSVTTDDWKNYLFTYF--KDQAE--ALNRVDWNAWMFTPGMPPVKPQ--YDTTLADACIALSQRWT------KAGDQDLDGFSESDVKTLSSHQLIEFLSLL--LHENPLPLTHVKKMQEVYGLNTCTNSEIRFRWLKLCVRSKWEEAVPLALKMATEQGRMKFTRPLFREVFNFNKYRDEAVQVFAAHRTAMHPVTAGLVAK 602          

Query:  328 DFENEQISGSVVHNVKVLNSASKELILDVRNLEIKRIVIDNED------VLFQYVNGKLGGKLVIPLSLGTKRSKFQVI-IEYNTTNDSTALQWMKPEMT--MGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVR-KSSTLSNDVRQHKFEQ-KIPIPSYLVSIACGHLVGSKIGPRST---VYSEPELNEKARLEFEDIEKILVIAEELCG-PYEWEICDLLILPPSFPYGGMEN-PCIIFLTPCLLTG-DKSQL------NYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLET-LIGKDKMLRWLKTYIAAFRLKSVSTD 1506
            D +N   +G  V N+ VL++ ++ ++L   NL I       +D       + QY   K   ++ +  +   K  ++ V+ + Y+    ST   +     T   G KH    +Q + ++AR  +PC D P  K T+   I    +   + +  + +S  L + + Q +FE+  + + +YLV+    +    +     T   VYS PE  E  R   E   K+L          Y  +  DL+ +P  F  G MEN   I F    LL G D S L      + +AHE++H W GNLVT   W+  W+NEG   Y++ L L+++        L + +    ++ D     +I         + P+      ++ F  V YEKG+ +L  L   L G+ +  + +  Y+  F   +  T+
Sbjct:  193 DLDNMTFAGIAVINMSVLHNTNR-IVLHGLNLNISNATFKIDDGPASNVTVLQY---KANQQIAVKFTEDLKAGQYCVLTLTYSANLSSTYDGFYSSSYTDKSGTKHILAATQFEPLSARKAFPCFDEPAFKATFLIKINRKQNYTTLSNMPQSESRLLPSGLFQDEFERTSVNMSTYLVAFVVANFSAVRKNVSETLVSVYSVPEKTEHTRYALEAASKLLEFYNTFFDIDYPLKKLDLVAIP-DFLAGAMENWGLITFRETTLLVGKDSSPLEKQVVASVVAHELAHQWFGNLVTMRWWNDLWLNEGFATYMQYLSLQRVFPELQAEILFLSVRFRVMDKD----ALISSHPVSTAVVTPD----QVEEMFDSVSYEKGASILLMLNAYLPGEQQFRKGIIQYLKQFSGSNTETN 596          

Query:  328 DFENEQISGSVVHNVKVLNSASKELILDVRNLEIKRIVIDNED------VLFQYVNGKLGGKLVIPLSLGTKRSKFQVI-IEYNTTNDSTALQWMKPEMT--MGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVR-KSSTLSNDVRQHKFEQ-KIPIPSYLVSIACGHLVGSKIGPRST---VYSEPELNEKARLEFEDIEKILVIAEELCG-PYEWEICDLLILPPSFPYGGMEN-PCIIFLTPCLLTG-DKSQL------NYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLET-LIGKDKMLRWLKTYIAAFRLKSVSTD 1506
            D +N   +G  V N+ VL++ ++ ++L   NL I       +D       + QY   K   ++ +  +   K  ++ V+ + Y+    ST   +     T   G KH    +Q + ++AR  +PC D P  K T+   I    +   + +  + +S  L + + Q +FE+  + + +YLV+    +    +     T   VYS PE  E  R   E   K+L          Y  +  DL+ +P  F  G MEN   I F    LL G D S L      + +AHE++H W GNLVT   W+  W+NEG   Y++ L L+++        L + +    ++ D     +I         + P+      ++ F  V YEKG+ +L  L   L G+ +  + +  Y+  F   +  T+
Sbjct:  194 DLDNMTFAGIAVINMSVLHNTNR-IVLHGLNLNISNATFKIDDGPASNVTVLQY---KANQQIAVKFTEDLKAGQYCVLTLTYSANLSSTYDGFYSSSYTDKSGTKHILAATQFEPLSARKAFPCFDEPAFKATFLIKINRKQNYTTLSNMPQSESRLLPSGLFQDEFERTSVNMSTYLVAFVVANFSAVRKNVSETLVSVYSVPEKTEHTRYALEAASKLLEFYNTFFDIDYPLKKLDLVAIP-DFLAGAMENWGLITFRETTLLVGKDSSPLEKQVVASVVAHELAHQWFGNLVTMRWWNDLWLNEGFATYMQYLSLQRVFPELQAEILFLSVRFRVMDKD----ALISSHPVSTAVVTPD----QVEEMFDSVSYEKGASILLMLNAYLPGEQQFRKGIIQYLKQFSGSNTETN 597          

Query:  643 QAINARSLYPCQDTPFVKTTYSATIEAPSDLEVV--MSAVRKSSTLSNDVRQHKFEQKIPIPSYLVSIACGHL-VGSKIGPRST---VYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDL-LILPPSFPYGGMEN-PCIIFLTPCLLTGDKSQ--------LNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHI---YLGISELEGDLNMYQII--YGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKMLRWLKTYIAAFRLKSVST-DEWKTF 1521
            +  +AR  +PC D P  K TY+ +I    D   +  M    K   L  +  +  F++ +P+ +YLV  A        KI  R     +Y++P     A       + I    EE    + + I  L  I  P F  G MEN   + +    LL  D+           + IAHE+ H W GN+VT   WD  W+NEG  ++ E + +EK + S   R + I    L +   +  L+ + II       E T +            F  + Y KG+ +L  LE  +G+D      + Y+  F  K+  T D W + 
Sbjct:  224 EPTDARKSFPCFDEPNKKATYNISITHHKDYRALSNMPQEVKCRLLPGNKLKTSFQKSVPMSTYLVCFAVHQFEFVEKISKRGIPLRIYAQPSQLGTAEFAANTTKVIFDYFEEYFDMF-YSISKLDQIAIPDFGTGAMENWGLVTYRETNLLYDDRESSSSNKQRVASVIAHELVHQWFGNIVTMDWWDDLWLNEGFASFFEYIGVEKAEPSWGMRDIMIISDVLPVMVNDALLSSHPIIVDVSTPAEITSV------------FDAISYSKGASVLRMLEDWMGRDAFRDGCRKYLKDFYFKNAKTADFWASL 525          

Query:  643 QAINARSLYPCQDTPFVKTTYSATIEAPSDLEVV--MSAVRKSSTLSNDVRQHKFEQKIPIPSYLVSIACGHL-VGSKIGPRST---VYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDL-LILPPSFPYGGMEN-PCIIFLTPCLLTGDKSQ--------LNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHI---YLGISELEGDLNMYQII--YGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKMLRWLKTYIAAFRLKSVST-DEWKTF 1521
            +  +AR  +PC D P  K TY+ +I    D   +  M    +   L  +  +  F++ +P+ +YLV  A        KI  R     +Y++P     A       + I    EE    + + I  L  I  P F  G MEN   + +    LL  D+           + IAHE+ H W GN+VT   WD  W+NEG  ++ E + +EK + S   R + I    L +   +  L+ + II       E T +            F  + Y KG+ +L  LE  +G+D      + Y+  F  K+  T D W + 
Sbjct:  224 EPTDARKSFPCFDEPNKKATYNISITHHKDYRALSNMPQEGQPEVLPGNKLKTSFQKSVPMSTYLVCFAVHQFEFVEKISKRGIPLRIYAQPSQLGTAEFAANTTKVIFDYFEEYFDMF-YSISKLDQIAIPDFGTGAMENWGLVTYRETNLLYDDRESSSSNKQRVASVIAHELVHQWFGNIVTMDWWDDLWLNEGFASFFEYIGVEKAEPSWGMRDIMIISDVLPVMVNDALLSSHPIIVDVSTPAEITSV------------FDAISYSKGASVLRMLEDWMGRDAFRDGCRKYLKDFYFKNAKTADFWASL 525          

Query:  244 MEFSQNDKTSYANSEDFIVDKSHFNWKLDFENEQISGSVVHNVKVLNSASKELILDVRNLEIKRIVIDNEDVLFQYVNGKLGGKLVIPLSLGTKRSKFQVIIEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSNDVRQHKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKMLRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLNKFSRMLPDQRYYFFQVLNDIQGVQLPESSLKVMGNIYGLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMHPITRGEIHKIIFPR 2097
            MEFSQNDKTSYANSEDFIVDKSHFNWKLDFENEQISGSVVHNVKVLNSASKELILDVRNLEIKRIVIDNEDVLFQYVNGKLGGKLVIPLSLGTKRSKFQVIIEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSNDVRQHKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKMLRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLN+FSRMLPDQRYYFFQVLN+IQGVQLPESSLKVMGNIYGLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMHPITRGEIHKIIFPR
Sbjct:    1 MEFSQNDKTSYANSEDFIVDKSHFNWKLDFENEQISGSVVHNVKVLNSASKELILDVRNLEIKRIVIDNEDVLFQYVNGKLGGKLVIPLSLGTKRSKFQVIIEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSSTLSNDVRQHKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKMLRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQFPSSENELLNRFSRMLPDQRYYFFQVLNEIQGVQLPESSLKVMGNIYGLTNTTNSELLHGWSLLCLRSHYMPAVDQVFEFLNSQGRLKYNKVLYKHLYDWDDTKSRTVENFHIQKFAMHPITRGEIHKIIFPR 618          

Query:  244 MEFSQNDKTSYANSEDFIVDKSHFNWKLDFENEQISGSVVHNVKVLNSASKELILDVRNLEIKRIVIDNEDVLFQYVNGK---LGGKLVIPLSLGTKRSKFQVIIEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVR-KSSTLSNDVRQHKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKMLRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPG 1608
            M  S ND  SYANSED++ +   F+W +DF+ + I GSV   +K L     +L LD + L+IK++ +   +  F  V+ K   LG  L IP+  G    KF V I+Y TT + TALQW+ PE T+GKKH +L+SQ QAI+ARSL+PCQD+P VK+TYSA ++AP+   V+MSA++ +  T   +   HKFEQK+ I SYLV+I CG+L G K+  RSTV+SEPE+ EKA  EF D E +L IAE +CG Y W I DLL+LPPSFPYGGMENPC+ F+TP LL GDKS +  +AHEI+HSWTGNLVTN TW+ FW+NEGHT Y+ERLI+EK   SE  RHL I +GI+EL+  LN     YG  H+F +LVP L   DPDDSFSRVPYEKGS LLF+LE + GKD+MLRWLK Y   ++ KS++TDEWK FF+KYMI+KE +  +KL+ + W   F + G
Sbjct:    1 MALSLNDPVSYANSEDYVTEHLDFDWIIDFDRKLIEGSVNLQLKNLTKKQADLKLDTKYLDIKKVSVKGTETRFDIVDCKIEALGSCLKIPI--GISDEKFSVCIQYATTANCTALQWLIPEATVGKKHPYLFSQCQAIHARSLFPCQDSPCVKSTYSAKVKAPNQFNVLMSAIKNEDPTKEGNHLIHKFEQKVNISSYLVAIVCGNLAGKKLSNRSTVWSEPEMVEKAAHEFADTENLLSIAESICGEYVWGIYDLLVLPPSFPYGGMENPCLTFVTPTLLVGDKSLVFVVAHEITHSWTGNLVTNKTWEDFWLNEGHTRYIERLIMEKYYDSELIRHLLISIGIAELQESLNA----YGEGHKFNQLVPVLVECDPDDSFSRVPYEKGSNLLFHLENICGKDQMLRWLKCYFEHYKYKSLTTDEWKAFFYKYMIDKENISKAKLDNVDWKKGFMEDG 453          

Query:  244 MEFSQNDKTSYANSEDFIVDKSHFNWKLDFENEQISGSVVHNVKVLNSASKELILDVRNLEIKRIVIDNEDVLFQYVNGK---LGGKLVIPLSLGTKRSKFQVIIEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVR-KSSTLSNDVRQHKFEQKIPIPSYLVSIACGHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGISELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKMLRWLKTYIAAFRLKSVSTDEWKTFFFKYMIEKEKVEPSKLEGIKWDDWFYKPGPIPIEHHSLLDDSMIQECNELVKAWIGFHQ--FPSSENELLNKFSRMLPDQRYYFFQV 1776
            M  S ND  SYANSED++ +   F+W +DF+ + I GSV   +K L     +L LD + L+IK++ +   +  F  V+ K   LG  L IP+  G    KF V I+Y TT + TALQW+ PE T+GKKH +L+SQ QAI+ARSL+PCQD+P VK+TYSA ++AP+   V+MSA++ +  T   +   HKFEQK+ I SYLV+I CG+L G K+  RSTV+SEPE+ EKA  EF D E +L IAE +CG Y W I DLL+LPPSFPYGGMENPC+ F+TP LL GDKS +  +AHEI+HSWTGNLVTN TW+ FW+NEGHT Y+ERLI+EK   SE  RHL I +GI+EL+  LN     YG  H+F +LVP L   DPDDSFSRVPYEKGS LLF+LE + GKD                                              W  WFY    IP++H    D     E   L   WI  +     S + +LL ++   LP Q+YYF QV
Sbjct:    1 MALSLNDPVSYANSEDYVTEHLDFDWIIDFDRKLIEGSVNLQLKNLTKKQADLKLDTKYLDIKKVSVKGTETRFDIVDCKIEALGSCLKIPI--GISDEKFSVCIQYATTANCTALQWLIPEATVGKKHPYLFSQCQAIHARSLFPCQDSPCVKSTYSAKVKAPNQFNVLMSAIKNEDPTKEGNHLIHKFEQKVNISSYLVAIVCGNLAGKKLSNRSTVWSEPEMVEKAAHEFADTENLLSIAESICGEYVWGIYDLLVLPPSFPYGGMENPCLTFVTPTLLVGDKSLVFVVAHEITHSWTGNLVTNKTWEDFWLNEGHTRYIERLIMEKYYDSELIRHLLISIGIAELQESLNA----YGEGHKFNQLVPVLVECDPDDSFSRVPYEKGSNLLFHLENICGKD----------------------------------------------WKKWFYGRWKIPVDHVLKRDHGDASE--RLADKWINLNPEISDSDQKDLLLEYESFLPHQKYYFLQV 463          

Query:  397 ELILDVRNLEIKRIVIDNEDVLFQYVNGKLGGKLVIPLS--LGTKRSKFQVIIEYNTTNDSTALQWMKPEMTMGKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSAVRKSST-LSNDVRQHKFEQKIPIPSYLVSIACGHL----VGSKIGPRSTVYSEPELNEKARLEFEDIEKIL-VIAEELCGPYEWEICDLLILPPSFPYGGMENPCIIFLTPCLLTGDKSQLN---------YIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSSEPYRHLHIYLGIS--ELEGDLNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKMLRWLKTYIAAFRLK-SVSTDEWKTF 1521
            E++L+  +L I   +++NE     YVN     +++IPLS  L   ++K  ++      ++         +    ++     +Q +A +AR  +PC D P +K T+  T+  P     + +   K  T +S  + + ++E+   + +YL++   G L         G R  VY+  + + + R   +   + L   A      Y     DL+ +P  F  G MEN  ++     +L  D+ + +          + HE +H W GNLVT   W   W+NEG   ++E L ++       Y    I+   S  E    LN+  +      + T   P+    + D+ F  + Y KG+ ++  L   +  +K  + L  Y+   R + +V+ D W   
Sbjct:   47 EIVLNATSLSITNAMVNNEKCSVTYVNEY--DRIIIPLSKPLLPGKAKLDLLFSGTLNDEMKGFYRSTYKTDSNEEIRMAVTQFEASDARRAFPCWDEPNIKATFDITLVVPKTKTALSNMPEKCRTEVSGSLVKIEYEKSPIMSTYLLAFVIGELDYVESHDSNGVRVRVYTAKDKSNRGRFALDVCCRTLPFYATYFDIVYPLPKMDLVAIP-DFAAGAMENWGLVTYRETMLLVDEHESSSLSKQIVALVVGHECAHMWFGNLVTMDWWTDLWLNEGFATWIEYLCVDYC-----YPEFDIWTNFSSDEYARALNLDALRSSHPIQVTVHKPS----EIDEIFDAISYSKGACVIRMLNDYLTNEKFKKGLSIYLKRHRYQNAVTADLWAAL 429          

Query:  610 GKKHSFLYSQSQAINARSLYPCQDTPFVKTTYSATIEAPSDLEVVMSA-VRKSSTLSNDVRQHKFEQKIPIPSYLVSIAC---------GHLVGSKIGPRSTVYSEPELNEKARLEFEDIEKILVIAEELCG-PYEWEICDLLILPPSFPYGGMENPCII---FLTPCL------LTGDKSQLNYIAHEISHSWTGNLVTNSTWDHFWVNEGHTNYLERLILEKLQSS-EPYRHLHIYLGISELEGD--LNMYQIIYGPDHEFTKLVPNLHGKDPDDSFSRVPYEKGSLLLFYLETLIGKDKMLRWLKTYIAAFRLKSVSTDE-WKTF 1521
            G + + + +  +   AR  +PC D P+ K  +S  +    D   + +  +R +  L+N +    +E  + + +YLV+            G+   +K   R  +Y+  +  +      E  +K+L   E L G  Y     D++ +P  F  G MEN  +I   F T  L      +    S    I+HEI+H W GN+VT   W+  W+NEG   Y E L  + +        H ++   +  L  D  LN + I           VP    ++ +  F ++ Y KG+ L+  LE ++G + +   LK Y+  +R ++  +D  W  F
Sbjct:  218 GVEKTLITTHMEPTFARQAFPCFDEPYFKANFSLRMVRDKDHHSLFNMPLRSTEKLANGLYCDSYETSVKMSTYLVAYMLLPLDYISLDGYASLNKTKIR--IYAPKDQKDYTSFALEIAQKVLPFFENLFGIDYPLPKLDMIAIP-DFSAGAMENWGLITYKFFTLLLNPKSPKIQHKTSIAKIISHEIAHQWFGNIVTMDWWNDLWLNEGFATYSEYLAGDYINREWGMIGHFYLEQFVDALNFDSLLNSHPI----------QVPVKDPQEIESIFDQISYGKGASLVRMLEGVLGLETLKVGLKIYLQRYRYQTAVSDNLWTAF 532