Ribosomal protein S6 kinase

Overview


Name	Ribosomal protein S6 kinase
Smed ID	SMED30033349
Length (bp)	2430

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Ribosomal protein S6 kinase (SMED30033349) t-SNE clustered cells

Violin plots show distribution of expression levels for Ribosomal protein S6 kinase (SMED30033349) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Ribosomal protein S6 kinase (SMED30033349) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Ribosomal protein S6 kinase (SMED30033349) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30033349

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 7

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
Smed sexual biotype	SMED30033349	h1SMcG0013596	Contig42223	newmark_ests	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30033349	h1SMcG0013596	Contig42223	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
protonephridia	SMED30033349	h1SMcG0013596	dd_Smed_v4_4316_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30033349	h1SMcG0013596	dd_Smed_v4_4316_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
posterior side	SMED30033349	h1SMcG0013596	dd_Smed_v4_4316_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
posterior muscle cell	SMED30033349	h1SMcG0013596	dd_Smed_v4_4316_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30033349	h1SMcG0013596	dd_Smed_v4_4316_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of Ribosomal protein S6 kinase vs. Ensembl Human
Match: RPS6KA1 (ribosomal protein S6 kinase A1 [Source:HGNC Symbol;Acc:HGNC:10430])

HSP 1 Score: 852.432 bits (2201), Expect = 0.000e+0
Identity = 433/697 (62.12%), Postives = 522/697 (74.89%), Query Frame = 2

Query:  218 EEATEVNAVDLVDEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKI-SGWQNIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKAL-LEKSLPNLAPVANSTLAKRRGQSKPKSS 2302
            +E +  + V    EK D SHFELL+VLGQGSFGKVFLVRKV+ P  G LYAMKVLKKA+LKV+DR RTKMERDILA + HPF+V LHYAFQ EGK+YLIL+FL+GGDLF+RLSKE MFTE+DVKFYLAELAL LDHLHSLGI+YRDLKPENILLDE+GHIKLTDFGLSKE+I  D   + +SFCGTVEYMAPEVVNR+GH  +ADWWS+GVLMFEMLTG LPFQG  RKETMT+ILKAKL MPQFLS+EAQ+LLR LFKRNP+NR+G GP G EEIK   F+  I+W  L  R++ PPFKP     DDT  FD++FTS+TPK+SP  P SA A+++FRGFS+VA  +++           + S  Q + G      D Y  +KE IG GS+S C R VHK T + YA+KVID +KRD  EE+EIL R+G HP+I+ LK+VY     V L+ E + GGELL  IL QK+FSE+EAS +L+ + +TV YLH+  VVHRDLKPSNILY  +  NPE L ICDFGFAKQ RAENGLLMTPCYTANFVAPEVLK+QGYD+  D+WSLG+LL+ ML+G TPF     D PEEIL RI    F L+GG W  +S  AKDL+ KMLH DP QR+T  Q+L H W+T +  LP ++++ + DL  VKGA+ ATY AL   K  P L P+ +S LA+RR +  P ++
Sbjct:   42 KEISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAI--DHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDSPGIPPSAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKNLVFSDGY-VVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQLS-HQDLQLVKGAMAATYSALNSSKPTPQLKPIESSILAQRRVRKLPSTT 734

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Query:  218 EEATEVNAVDLVDEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKI-SGWQNIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKAL-LEKSLPNLAPVANSTLAKRRGQSKPKSS 2302
            +E +  + V    EK D SHFELL+VLGQGSFGKVFLVRKV+ P  G LYAMKVLKKA+LKV+DR RTKMERDILA + HPF+V LHYAFQ EGK+YLIL+FL+GGDLF+RLSKE MFTE+DVKFYLAELAL LDHLHSLGI+YRDLKPENILLDE+GHIKLTDFGLSKE+I  D   + +SFCGTVEYMAPEVVNR+GH  +ADWWS+GVLMFEMLTG LPFQG  RKETMT+ILKAKL MPQFLS+EAQ+LLR LFKRNP+NR+G GP G EEIK   F+  I+W  L  R++ PPFKP     DDT  FD++FTS+TPK+SP  P SA A+++FRGFS+VA  +++           + S  Q + G      D Y  +KE IG GS+S C R VHK T + YA+KVID +KRD  EE+EIL R+G HP+I+ LK+VY     V L+ E + GGELL  IL QK+FSE+EAS +L+ + +TV YLH+  VVHRDLKPSNILY  +  NPE L ICDFGFAKQ RAENGLLMTPCYTANFVAPEVLK+QGYD+  D+WSLG+LL+ ML+G TPF     D PEEIL RI    F L+GG W  +S  AKDL+ KMLH DP QR+T  Q+L H W+T +  LP ++++ + DL  VKGA+ ATY AL   K  P L P+ +S LA+RR +  P ++
Sbjct:   42 KEISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAI--DHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDSPGIPPSAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKNLVFSDGY-VVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQLS-HQDLQLVKGAMAATYSALNSSKPTPQLKPIESSILAQRRVRKLPSTT 734

[Close]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Human
Match: RPS6KA1 (ribosomal protein S6 kinase A1 [Source:HGNC Symbol;Acc:HGNC:10430])

HSP 1 Score: 852.047 bits (2200), Expect = 0.000e+0
Identity = 433/697 (62.12%), Postives = 522/697 (74.89%), Query Frame = 2

Query:  218 EEATEVNAVDLVDEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKI-SGWQNIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKAL-LEKSLPNLAPVANSTLAKRRGQSKPKSS 2302
            +E +  + V    EK D SHFELL+VLGQGSFGKVFLVRKV+ P  G LYAMKVLKKA+LKV+DR RTKMERDILA + HPF+V LHYAFQ EGK+YLIL+FL+GGDLF+RLSKE MFTE+DVKFYLAELAL LDHLHSLGI+YRDLKPENILLDE+GHIKLTDFGLSKE+I  D   + +SFCGTVEYMAPEVVNR+GH  +ADWWS+GVLMFEMLTG LPFQG  RKETMT+ILKAKL MPQFLS+EAQ+LLR LFKRNP+NR+G GP G EEIK   F+  I+W  L  R++ PPFKP     DDT  FD++FTS+TPK+SP  P SA A+++FRGFS+VA  +++           + S  Q + G      D Y  +KE IG GS+S C R VHK T + YA+KVID +KRD  EE+EIL R+G HP+I+ LK+VY     V L+ E + GGELL  IL QK+FSE+EAS +L+ + +TV YLH+  VVHRDLKPSNILY  +  NPE L ICDFGFAKQ RAENGLLMTPCYTANFVAPEVLK+QGYD+  D+WSLG+LL+ ML+G TPF     D PEEIL RI    F L+GG W  +S  AKDL+ KMLH DP QR+T  Q+L H W+T +  LP ++++ + DL  VKGA+ ATY AL   K  P L P+ +S LA+RR +  P ++
Sbjct:   26 KEISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAI--DHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDSPGIPPSAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKNLVFSDGY-VVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQLS-HQDLQLVKGAMAATYSALNSSKPTPQLKPIESSILAQRRVRKLPSTT 718

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Query:  218 EEATEVNAVDLVDEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKI-SGWQNIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKAL-LEKSLPNLAPVANSTLAKRRGQSKPKSS 2302
            +E +  + V    EK D SHFELL+VLGQGSFGKVFLVRKV+ P  G LYAMKVLKKA+LKV+DR RTKMERDILA + HPF+V LHYAFQ EGK+YLIL+FL+GGDLF+RLSKE MFTE+DVKFYLAELAL LDHLHSLGI+YRDLKPENILLDE+GHIKLTDFGLSKE+I  D   + +SFCGTVEYMAPEVVNR+GH  +ADWWS+GVLMFEMLTG LPFQG  RKETMT+ILKAKL MPQFLS+EAQ+LLR LFKRNP+NR+G GP G EEIK   F+  I+W  L  R++ PPFKP     DDT  FD++FTS+TPK+SP  P SA A+++FRGFS+VA  +++           + S  Q + G      D Y  +KE IG GS+S C R VHK T + YA+KVID +KRD  EE+EIL R+G HP+I+ LK+VY     V L+ E + GGELL  IL QK+FSE+EAS +L+ + +TV YLH+  VVHRDLKPSNILY  +  NPE L ICDFGFAKQ RAENGLLMTPCYTANFVAPEVLK+QGYD+  D+WSLG+LL+ ML+G TPF     D PEEIL RI    F L+GG W  +S  AKDL+ KMLH DP QR+T  Q+L H W+T +  LP ++++ + DL  VKGA+ ATY AL   K  P L P+ +S LA+RR +  P ++
Sbjct:   26 KEISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAI--DHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDSPGIPPSAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKNLVFSDGY-VVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQLS-HQDLQLVKGAMAATYSALNSSKPTPQLKPIESSILAQRRVRKLPSTT 718

[Close]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Human
Match: RPS6KA1 (ribosomal protein S6 kinase A1 [Source:HGNC Symbol;Acc:HGNC:10430])

HSP 1 Score: 851.662 bits (2199), Expect = 0.000e+0
Identity = 433/697 (62.12%), Postives = 522/697 (74.89%), Query Frame = 2

Query:  218 EEATEVNAVDLVDEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKI-SGWQNIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKAL-LEKSLPNLAPVANSTLAKRRGQSKPKSS 2302
            +E +  + V    EK D SHFELL+VLGQGSFGKVFLVRKV+ P  G LYAMKVLKKA+LKV+DR RTKMERDILA + HPF+V LHYAFQ EGK+YLIL+FL+GGDLF+RLSKE MFTE+DVKFYLAELAL LDHLHSLGI+YRDLKPENILLDE+GHIKLTDFGLSKE+I  D   + +SFCGTVEYMAPEVVNR+GH  +ADWWS+GVLMFEMLTG LPFQG  RKETMT+ILKAKL MPQFLS+EAQ+LLR LFKRNP+NR+G GP G EEIK   F+  I+W  L  R++ PPFKP     DDT  FD++FTS+TPK+SP  P SA A+++FRGFS+VA  +++           + S  Q + G      D Y  +KE IG GS+S C R VHK T + YA+KVID +KRD  EE+EIL R+G HP+I+ LK+VY     V L+ E + GGELL  IL QK+FSE+EAS +L+ + +TV YLH+  VVHRDLKPSNILY  +  NPE L ICDFGFAKQ RAENGLLMTPCYTANFVAPEVLK+QGYD+  D+WSLG+LL+ ML+G TPF     D PEEIL RI    F L+GG W  +S  AKDL+ KMLH DP QR+T  Q+L H W+T +  LP ++++ + DL  VKGA+ ATY AL   K  P L P+ +S LA+RR +  P ++
Sbjct:   51 KEISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAI--DHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDSPGIPPSAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKNLVFSDGY-VVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQLS-HQDLQLVKGAMAATYSALNSSKPTPQLKPIESSILAQRRVRKLPSTT 743

[Close]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Celegans
Match: rskn-1 (Putative ribosomal protein S6 kinase alpha-1 [Source:UniProtKB/Swiss-Prot;Acc:Q21734])

HSP 1 Score: 768.459 bits (1983), Expect = 0.000e+0
Identity = 404/714 (56.58%), Postives = 505/714 (70.73%), Query Frame = 2

Query:  185 EEFSDNAFSQEEEATEVNA---VDLVD-----EKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKISGWQNIVGVKFQKVDHY---YTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYF-SEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNS----DLSSVKGAVKATYKALLEKSLPNLAPVANSTLAKRR 2278
            EEF++N   Q EE T+ ++   +D+ D     EK D   FELL+VLGQGSFGKVFLVRKV     G +YAMKVLKKA+LKV+DR+RTK+ER+ILA I HPFIV LHYAFQ EGK+YLIL+FL+GGDLF+RLSKE MFTEDDVKFYLAEL LAL+HLHSLGIVYRDLKPENILLD DGHIK+TDFGLSKE+I  D   +T+SFCGTVEYMAPEV+NR+GH  AAD+WS GVLMFEMLTG LPFQG  R +TMT ILKAKLSMP FL+ EAQ+LLR LFKRN  NR+G GP G+EEIK   FF  I++  LLN+++ PPFKP  + +D TS FD +FT +TPK+SP  PASA  +EIFRGFS+V+        NA +E+ K+   +++  V   K + +   Y + E+IG G+ SV ++   K T   YA+K++     D  EEV+IL R   H  +VKL +VY  +  + +I E  EGGELL  ++++K   SEKE + I+  L   V YLH+  V HRDL  +NIL++ KD +P +L I DFGFAKQ RAENG+LMTPCYTA FVAPEVL+KQGYD++ DVWSLGVLL  ML+G TPF    +D P++IL+R+      +T   W+ IS EAKDL+ KML  DP +R+T  Q L H WI  + +LP   I        D+ +VK A++ TYKA+       L PV +S LAKRR
Sbjct:    8 EEFAENEIEQGEEKTDSSSETEIDIGDVRKCGEKADPRQFELLKVLGQGSFGKVFLVRKVRGRDSGHVYAMKVLKKATLKVRDRQRTKLERNILAHISHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEDDVKFYLAELTLALEHLHSLGIVYRDLKPENILLDADGHIKVTDFGLSKEAI--DSEKKTYSFCGTVEYMAPEVINRRGHSMAADFWSLGVLMFEMLTGHLPFQGRDRNDTMTQILKAKLSMPHFLTQEAQSLLRALFKRNSQNRLGAGPDGVEEIKRHAFFAKIDFVKLLNKEIDPPFKPALSTVDSTSYFDPEFTKRTPKDSPALPASANGHEIFRGFSFVS--------NAVMEERKLIA-KSVRSVPTAKTNPFTDDYEILEKIGNGAHSVVHKCQMKATRRKYAVKIVKKAVFDATEEVDILLRHSHHQFVVKLFDVYEDETAIYMIEELCEGGELLDKLVNKKSLGSEKEVAAIMANLLNAVQYLHSQQVAHRDLTAANILFALKDGDPSSLRIVDFGFAKQSRAENGMLMTPCYTAQFVAPEVLRKQGYDRSCDVWSLGVLLHTMLTGCTPFAMGPNDTPDQILQRVGDGKISMTHPVWDTISDEAKDLVRKMLDVDPNRRVTAKQALQHKWIGQKEALPDRPIQSEQVGELDMQNVKVALEQTYKAIASAPSVQLRPVGSSALAKRR 710

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BLAST of Ribosomal protein S6 kinase vs. Ensembl Celegans
Match: rskn-1 (Putative ribosomal protein S6 kinase alpha-1 [Source:UniProtKB/Swiss-Prot;Acc:Q21734])

HSP 1 Score: 760.37 bits (1962), Expect = 0.000e+0
Identity = 405/733 (55.25%), Postives = 509/733 (69.44%), Query Frame = 2

Query:  122 MPLGPVTDSFHI--SNLNEVE--VDEEFSDNAFSQEEEATEVNAVDL--VDEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKISGWQNIVGVKFQKVDHY---YTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYF-SEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNS----DLSSVKGAVKATYKALLEKSLPNLAPVANSTLAKRR 2278
            MPL  + + F I  S++  V   +D+       +     TE++  D+    EK D   FELL+VLGQGSFGKVFLVRKV     G +YAMKVLKKA+LKV+DR+RTK+ER+ILA I HPFIV LHYAFQ EGK+YLIL+FL+GGDLF+RLSKE MFTEDDVKFYLAEL LAL+HLHSLGIVYRDLKPENILLD DGHIK+TDFGLSKE+I  D   +T+SFCGTVEYMAPEV+NR+GH  AAD+WS GVLMFEMLTG LPFQG  R +TMT ILKAKLSMP FL+ EAQ+LLR LFKRN  NR+G GP G+EEIK   FF  I++  LLN+++ PPFKP  + +D TS FD +FT +TPK+SP  PASA  +EIFRGFS+V+        NA +E+ K+   +++  V   K + +   Y + E+IG G+ SV ++   K T   YA+K++     D  EEV+IL R   H  +VKL +VY  +  + +I E  EGGELL  ++++K   SEKE + I+  L   V YLH+  V HRDL  +NIL++ KD +P +L I DFGFAKQ RAENG+LMTPCYTA FVAPEVL+KQGYD++ DVWSLGVLL  ML+G TPF    +D P++IL+R+      +T   W+ IS EAKDL+ KML  DP +R+T  Q L H WI  + +LP   I        D+ +VK A++ TYKA+       L PV +S LAKRR
Sbjct:    7 MPLAQLGEPFGITPSSIENVSPGIDQCKDHRMDTDSSSETEIDIGDVRKCGEKADPRQFELLKVLGQGSFGKVFLVRKVRGRDSGHVYAMKVLKKATLKVRDRQRTKLERNILAHISHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEDDVKFYLAELTLALEHLHSLGIVYRDLKPENILLDADGHIKVTDFGLSKEAI--DSEKKTYSFCGTVEYMAPEVINRRGHSMAADFWSLGVLMFEMLTGHLPFQGRDRNDTMTQILKAKLSMPHFLTQEAQSLLRALFKRNSQNRLGAGPDGVEEIKRHAFFAKIDFVKLLNKEIDPPFKPALSTVDSTSYFDPEFTKRTPKDSPALPASANGHEIFRGFSFVS--------NAVMEERKLIA-KSVRSVPTAKTNPFTDDYEILEKIGNGAHSVVHKCQMKATRRKYAVKIVKKAVFDATEEVDILLRHSHHQFVVKLFDVYEDETAIYMIEELCEGGELLDKLVNKKSLGSEKEVAAIMANLLNAVQYLHSQQVAHRDLTAANILFALKDGDPSSLRIVDFGFAKQSRAENGMLMTPCYTAQFVAPEVLRKQGYDRSCDVWSLGVLLHTMLTGCTPFAMGPNDTPDQILQRVGDGKISMTHPVWDTISDEAKDLVRKMLDVDPNRRVTAKQALQHKWIGQKEALPDRPIQSEQVGELDMQNVKVALEQTYKAIASAPSVQLRPVGSSALAKRR 728

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BLAST of Ribosomal protein S6 kinase vs. Ensembl Celegans
Match: rskn-1 (Putative ribosomal protein S6 kinase alpha-1 [Source:UniProtKB/Swiss-Prot;Acc:Q21734])

HSP 1 Score: 759.599 bits (1960), Expect = 0.000e+0
Identity = 403/729 (55.28%), Postives = 505/729 (69.27%), Query Frame = 2

Query:  140 TDSFHISNLNEVEVDEEFSDNAF--------SQEEEATEVNAVDLVDEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKISGWQNIVGVKFQKVDHY---YTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYF-SEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNS----DLSSVKGAVKATYKALLEKSLPNLAPVANSTLAKRR 2278
            T++FH S    + + +   +N F        S  E   ++  V    EK D   FELL+VLGQGSFGKVFLVRKV     G +YAMKVLKKA+LKV+DR+RTK+ER+ILA I HPFIV LHYAFQ EGK+YLIL+FL+GGDLF+RLSKE MFTEDDVKFYLAEL LAL+HLHSLGIVYRDLKPENILLD DGHIK+TDFGLSKE+I  D   +T+SFCGTVEYMAPEV+NR+GH  AAD+WS GVLMFEMLTG LPFQG  R +TMT ILKAKLSMP FL+ EAQ+LLR LFKRN  NR+G GP G+EEIK   FF  I++  LLN+++ PPFKP  + +D TS FD +FT +TPK+SP  PASA  +EIFRGFS+V+        NA +E+ K+   +++  V   K + +   Y + E+IG G+ SV ++   K T   YA+K++     D  EEV+IL R   H  +VKL +VY  +  + +I E  EGGELL  ++++K   SEKE + I+  L   V YLH+  V HRDL  +NIL++ KD +P +L I DFGFAKQ RAENG+LMTPCYTA FVAPEVL+KQGYD++ DVWSLGVLL  ML+G TPF    +D P++IL+R+      +T   W+ IS EAKDL+ KML  DP +R+T  Q L H WI  + +LP   I        D+ +VK A++ TYKA+       L PV +S LAKRR
Sbjct:   54 TNTFHSS----IHIIQPPPNNGFRLMNWKTDSSSETEIDIGDVRKCGEKADPRQFELLKVLGQGSFGKVFLVRKVRGRDSGHVYAMKVLKKATLKVRDRQRTKLERNILAHISHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEDDVKFYLAELTLALEHLHSLGIVYRDLKPENILLDADGHIKVTDFGLSKEAI--DSEKKTYSFCGTVEYMAPEVINRRGHSMAADFWSLGVLMFEMLTGHLPFQGRDRNDTMTQILKAKLSMPHFLTQEAQSLLRALFKRNSQNRLGAGPDGVEEIKRHAFFAKIDFVKLLNKEIDPPFKPALSTVDSTSYFDPEFTKRTPKDSPALPASANGHEIFRGFSFVS--------NAVMEERKLIA-KSVRSVPTAKTNPFTDDYEILEKIGNGAHSVVHKCQMKATRRKYAVKIVKKAVFDATEEVDILLRHSHHQFVVKLFDVYEDETAIYMIEELCEGGELLDKLVNKKSLGSEKEVAAIMANLLNAVQYLHSQQVAHRDLTAANILFALKDGDPSSLRIVDFGFAKQSRAENGMLMTPCYTAQFVAPEVLRKQGYDRSCDVWSLGVLLHTMLTGCTPFAMGPNDTPDQILQRVGDGKISMTHPVWDTISDEAKDLVRKMLDVDPNRRVTAKQALQHKWIGQKEALPDRPIQSEQVGELDMQNVKVALEQTYKAIASAPSVQLRPVGSSALAKRR 767

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BLAST of Ribosomal protein S6 kinase vs. Ensembl Celegans
Match: rskn-1 (Putative ribosomal protein S6 kinase alpha-1 [Source:UniProtKB/Swiss-Prot;Acc:Q21734])

HSP 1 Score: 753.821 bits (1945), Expect = 0.000e+0
Identity = 403/732 (55.05%), Postives = 505/732 (68.99%), Query Frame = 2

Query:  137 VTDSFHISNLNEVEVDEEFSDNAF--------SQEEEATEVNAVDLVDEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKISGWQNIVGVKFQKVDHY---YTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYF-SEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNS----DLSSVK--GAVKATYKALLEKSLPNLAPVANSTLAKRR 2278
             T++FH S    + + +   +N F        S  E   ++  V    EK D   FELL+VLGQGSFGKVFLVRKV     G +YAMKVLKKA+LKV+DR+RTK+ER+ILA I HPFIV LHYAFQ EGK+YLIL+FL+GGDLF+RLSKE MFTEDDVKFYLAEL LAL+HLHSLGIVYRDLKPENILLD DGHIK+TDFGLSKE+I  D   +T+SFCGTVEYMAPEV+NR+GH  AAD+WS GVLMFEMLTG LPFQG  R +TMT ILKAKLSMP FL+ EAQ+LLR LFKRN  NR+G GP G+EEIK   FF  I++  LLN+++ PPFKP  + +D TS FD +FT +TPK+SP  PASA  +EIFRGFS+V+        NA +E+ K+   +++  V   K + +   Y + E+IG G+ SV ++   K T   YA+K++     D  EEV+IL R   H  +VKL +VY  +  + +I E  EGGELL  ++++K   SEKE + I+  L   V YLH+  V HRDL  +NIL++ KD +P +L I DFGFAKQ RAENG+LMTPCYTA FVAPEVL+KQGYD++ DVWSLGVLL  ML+G TPF    +D P++IL+R+      +T   W+ IS EAKDL+ KML  DP +R+T  Q L H WI  + +LP   I        D+ +VK   A++ TYKA+       L PV +S LAKRR
Sbjct:   47 TTNTFHSS----IHIIQPPPNNGFRLMNWKTDSSSETEIDIGDVRKCGEKADPRQFELLKVLGQGSFGKVFLVRKVRGRDSGHVYAMKVLKKATLKVRDRQRTKLERNILAHISHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEDDVKFYLAELTLALEHLHSLGIVYRDLKPENILLDADGHIKVTDFGLSKEAI--DSEKKTYSFCGTVEYMAPEVINRRGHSMAADFWSLGVLMFEMLTGHLPFQGRDRNDTMTQILKAKLSMPHFLTQEAQSLLRALFKRNSQNRLGAGPDGVEEIKRHAFFAKIDFVKLLNKEIDPPFKPALSTVDSTSYFDPEFTKRTPKDSPALPASANGHEIFRGFSFVS--------NAVMEERKLIA-KSVRSVPTAKTNPFTDDYEILEKIGNGAHSVVHKCQMKATRRKYAVKIVKKAVFDATEEVDILLRHSHHQFVVKLFDVYEDETAIYMIEELCEGGELLDKLVNKKSLGSEKEVAAIMANLLNAVQYLHSQQVAHRDLTAANILFALKDGDPSSLRIVDFGFAKQSRAENGMLMTPCYTAQFVAPEVLRKQGYDRSCDVWSLGVLLHTMLTGCTPFAMGPNDTPDQILQRVGDGKISMTHPVWDTISDEAKDLVRKMLDVDPNRRVTAKQALQHKWIGQKEALPDRPIQSEQVGELDMQNVKFQVALEQTYKAIASAPSVQLRPVGSSALAKRR 763

[Close]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Celegans
Match: rskn-1 (Putative ribosomal protein S6 kinase alpha-1 [Source:UniProtKB/Swiss-Prot;Acc:Q21734])

HSP 1 Score: 704.516 bits (1817), Expect = 0.000e+0
Identity = 368/627 (58.69%), Postives = 454/627 (72.41%), Query Frame = 2

Query:  209 SQEEEATEVNAVDLVDEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKISGWQNIVGVKFQKVDHY---YTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYF-SEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCD 2077
            S  E   ++  V    EK D   FELL+VLGQGSFGKVFLVRKV     G +YAMKVLKKA+LKV+DR+RTK+ER+ILA I HPFIV LHYAFQ EGK+YLIL+FL+GGDLF+RLSKE MFTEDDVKFYLAEL LAL+HLHSLGIVYRDLKPENILLD DGHIK+TDFGLSKE+I  D   +T+SFCGTVEYMAPEV+NR+GH  AAD+WS GVLMFEMLTG LPFQG  R +TMT ILKAKLSMP FL+ EAQ+LLR LFKRN  NR+G GP G+EEIK   FF  I++  LLN+++ PPFKP  + +D TS FD +FT +TPK+SP  PASA  +EIFRGFS+V+        NA +E+ K+   +++  V   K + +   Y + E+IG G+ SV ++   K T   YA+K++     D  EEV+IL R   H  +VKL +VY  +  + +I E  EGGELL  ++++K   SEKE + I+  L   V YLH+  V HRDL  +NIL++ KD +P +L I DFGFAKQ RAENG+LMTPCYTA FVAPEVL+KQGYD++ DVWSLGVLL  ML+G TPF    +D P++IL+R+      +T   W+ IS EAKDL  K  HC+
Sbjct:   62 SSSETEIDIGDVRKCGEKADPRQFELLKVLGQGSFGKVFLVRKVRGRDSGHVYAMKVLKKATLKVRDRQRTKLERNILAHISHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEDDVKFYLAELTLALEHLHSLGIVYRDLKPENILLDADGHIKVTDFGLSKEAI--DSEKKTYSFCGTVEYMAPEVINRRGHSMAADFWSLGVLMFEMLTGHLPFQGRDRNDTMTQILKAKLSMPHFLTQEAQSLLRALFKRNSQNRLGAGPDGVEEIKRHAFFAKIDFVKLLNKEIDPPFKPALSTVDSTSYFDPEFTKRTPKDSPALPASANGHEIFRGFSFVS--------NAVMEERKLIA-KSVRSVPTAKTNPFTDDYEILEKIGNGAHSVVHKCQMKATRRKYAVKIVKKAVFDATEEVDILLRHSHHQFVVKLFDVYEDETAIYMIEELCEGGELLDKLVNKKSLGSEKEVAAIMANLLNAVQYLHSQQVAHRDLTAANILFALKDGDPSSLRIVDFGFAKQSRAENGMLMTPCYTAQFVAPEVLRKQGYDRSCDVWSLGVLLHTMLTGCTPFAMGPNDTPDQILQRVGDGKISMTHPVWDTISDEAKDLQNK--HCN 675

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BLAST of Ribosomal protein S6 kinase vs. Ensembl Fly
Match: S6kII (gene:FBgn0262866 transcript:FBtr0333715)

HSP 1 Score: 734.176 bits (1894), Expect = 0.000e+0
Identity = 393/720 (54.58%), Postives = 488/720 (67.78%), Query Frame = 2

Query:  257 EKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNAN----------------IEDMKISGWQNIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVID---------GTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWI--TFRSSLPSTK--IAMNSDLS-------------SVKGAVKATYKALLEKSLPNLAPVANSTLAKRRGQSK 2290
            +K D S FELLRVLG+GSFGKVFLVRK+     G LYAMKVLKKA+LKV+DR R+  ER ILA + H FIV LHYAFQ  GK+YLIL+FL+GGDLF+RLSKE MFTE+DVKFYLAELALA++HLH+LGI+YRDLKPENILLDE GHI LTDFGLSK+ +   D ++T+SFCGTVEYMAPE+VNRKGH  AADWWSFGVLM+EMLTG LPF G +R+ETM  IL++KL MP+ LS EAQ+LLR LFKRNP NR+G G +GI +IK+  FF  I+W  L  ++V PPF P A   DD   FD ++TSK+P++SP  P SA+A+EIFRGFS+VAP VL   Q A                 I    +   + + GV        Y L +E+G+G+FSVC    H+ +  +YA+KVI+          T  D  EEVEI+ R+G HP+IV L  VY    +  L+ME L+GGELL  IL+     E EAS +L  +   V YLH + VVHRDLKPSN++Y+     PE L +CD GFAKQ RA+NGLLMTPCYTANFVAPEVLK+QGYD A D+WSLGVLL+IMLSG+TPF    +D P+ ILKRI       T  +W  IS  AK+LL +MLH  P  R T  +IL H+W+   F   +  T+  +A  S LS             +++GAV AT++A+      N+ PV  S LAKRR + +
Sbjct:  192 DKADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVKDRVRSTNERKILADVGHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPL---DGSKTYSFCGTVEYMAPEIVNRKGHDFAADWWSFGVLMYEMLTGNLPFHGQTRQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFATIDWVRLERKQVRPPFIP-AVSRDDAFYFDVEYTSKSPRDSPGGPISASAHEIFRGFSFVAP-VLLEGQCAGSNMCSTSASPLHSIAPIPAAPVGAPRTLPGVLPGNFHAEYNLLQELGRGTFSVCRLCEHRASKKHYAVKVIEKAAVAAASTSTSADCWEEVEIMLRYGNHPNIVTLYSVYEDAGSAYLVMELLKGGELLDRILAVGQMCESEASAVLRTIASAVAYLHEHGVVHRDLKPSNMIYASMRQTPETLKLCDLGFAKQLRADNGLLMTPCYTANFVAPEVLKRQGYDLACDIWSLGVLLYIMLSGRTPFASTPNDSPDVILKRIGSGQIDFTSSRWALISVPAKELLRQMLHIVPENRPTAARILEHDWLREQFAGGVQLTEYAVAPGSQLSLGAQQQQQNHISMALRGAVDATFRAIAIPQAANVGPVELSMLAKRRAKDR 906

[Close]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Fly
Match: S6kII (gene:FBgn0262866 transcript:FBtr0077360)

HSP 1 Score: 734.176 bits (1894), Expect = 0.000e+0
Identity = 393/720 (54.58%), Postives = 488/720 (67.78%), Query Frame = 2

Query:  257 EKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNAN----------------IEDMKISGWQNIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVID---------GTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWI--TFRSSLPSTK--IAMNSDLS-------------SVKGAVKATYKALLEKSLPNLAPVANSTLAKRRGQSK 2290
            +K D S FELLRVLG+GSFGKVFLVRK+     G LYAMKVLKKA+LKV+DR R+  ER ILA + H FIV LHYAFQ  GK+YLIL+FL+GGDLF+RLSKE MFTE+DVKFYLAELALA++HLH+LGI+YRDLKPENILLDE GHI LTDFGLSK+ +   D ++T+SFCGTVEYMAPE+VNRKGH  AADWWSFGVLM+EMLTG LPF G +R+ETM  IL++KL MP+ LS EAQ+LLR LFKRNP NR+G G +GI +IK+  FF  I+W  L  ++V PPF P A   DD   FD ++TSK+P++SP  P SA+A+EIFRGFS+VAP VL   Q A                 I    +   + + GV        Y L +E+G+G+FSVC    H+ +  +YA+KVI+          T  D  EEVEI+ R+G HP+IV L  VY    +  L+ME L+GGELL  IL+     E EAS +L  +   V YLH + VVHRDLKPSN++Y+     PE L +CD GFAKQ RA+NGLLMTPCYTANFVAPEVLK+QGYD A D+WSLGVLL+IMLSG+TPF    +D P+ ILKRI       T  +W  IS  AK+LL +MLH  P  R T  +IL H+W+   F   +  T+  +A  S LS             +++GAV AT++A+      N+ PV  S LAKRR + +
Sbjct:  192 DKADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVKDRVRSTNERKILADVGHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPL---DGSKTYSFCGTVEYMAPEIVNRKGHDFAADWWSFGVLMYEMLTGNLPFHGQTRQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFATIDWVRLERKQVRPPFIP-AVSRDDAFYFDVEYTSKSPRDSPGGPISASAHEIFRGFSFVAP-VLLEGQCAGSNMCSTSASPLHSIAPIPAAPVGAPRTLPGVLPGNFHAEYNLLQELGRGTFSVCRLCEHRASKKHYAVKVIEKAAVAAASTSTSADCWEEVEIMLRYGNHPNIVTLYSVYEDAGSAYLVMELLKGGELLDRILAVGQMCESEASAVLRTIASAVAYLHEHGVVHRDLKPSNMIYASMRQTPETLKLCDLGFAKQLRADNGLLMTPCYTANFVAPEVLKRQGYDLACDIWSLGVLLYIMLSGRTPFASTPNDSPDVILKRIGSGQIDFTSSRWALISVPAKELLRQMLHIVPENRPTAARILEHDWLREQFAGGVQLTEYAVAPGSQLSLGAQQQQQNHISMALRGAVDATFRAIAIPQAANVGPVELSMLAKRRAKDR 906

[Close]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Fly
Match: JIL-1 (gene:FBgn0020412 transcript:FBtr0076237)

HSP 1 Score: 384.8 bits (987), Expect = 1.383e-117
Identity = 242/661 (36.61%), Postives = 359/661 (54.31%), Query Frame = 2

Query:  254 DEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRK---RTKMERDILAAI-RHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNR--KGHGTAADWWSFGVLMFEMLTGQLPFQGSS----RKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKI--SGWQNIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTK---RDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQG---YDKASDVWSLGVLLFIMLSGKTPFTQNEHD------PPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAM 2164
            DE +  + F+++RVLG G++G+VFLVRK++    G LYAMKVL K ++ VQ RK    TK ER +L AI R+PF+V+LHYAFQ+  K+YL+L+F  GG+LF+ L     F E  V+ Y+AE+ LAL+ LH LGI+YRD+K ENILLD +GHI L+DFGLSK  +  ++  R  SFCGT+EYMAPE++     GH +A DWWS GVL FE+LTG  PF  S     + E    I K +  +P   S+ A+  +  + ++NP  R+G   +   EIK  PFF  INW++L  ++   P+KP  T  DD   F ++FT + P++  C  A  +   +FRG++YVAP+ L+  +  N  +++   +G QNI      + D    L      G++  C+  V  +T + +  K+I  +K    +V   +        H +IV     + ++    ++MEYL G EL  +I       E    +I   L   V ++H+   +H DLKP NI++  ++     L+  DFG A            P YT ++  PE+L       Y  A D++ LG  L+ ML G  P+ QNE D         E+ KR+ + +F     +WE  S   + L+   L  DPA R T + IL   W+ + S+ P   I +
Sbjct:  253 DEAVSLNDFKIIRVLGTGAYGRVFLVRKLTRHDAGKLYAMKVLNKITV-VQKRKTAEHTKTERVVLEAIQRNPFLVSLHYAFQSSSKLYLVLDFANGGELFTHLYHSENFEESRVRVYIAEVVLALEQLHQLGIIYRDIKLENILLDGEGHIVLSDFGLSK-ILTAENEYRAHSFCGTLEYMAPEIIRTGPPGHDSAVDWWSVGVLTFELLTGASPFATSDGQVQQSEISRRIQKEQPMIPSSFSANARDFVLKMLEKNPKRRLGGNHRDASEIKEHPFFNGINWQELRTKRRKAPYKPTLTAEDDVQNFSNEFTDQVPEDPECD-APPSRIRLFRGYTYVAPEHLEQMRRDNHCEIQYFNTGLQNIPC----RPDD-LELGTRTSNGAYGTCHFVVDSSTDLVFLAKIIPLSKFRPSEVDALISCALDTTNHKNIVSYHGTFREKCETWIVMEYLSGPELTASI----RMDEDSCREIFLQLVMAVRHIHSKHFIHGDLKPENIMFENREDRTVKLI--DFGSACYNNRFKSWKDKPRYTLDYAPPEMLADANLVTYSPAVDIYGLGATLYTMLVGHRPYRQNEDDVDHSAAAHHELRKRMRRGTFNQRSMRWESASPAFRHLVSWCLQRDPADRPTLSDILDSEWLQYGSNDPDVDIIL 899

[Close]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Fly
Match: JIL-1 (gene:FBgn0020412 transcript:FBtr0332707)

HSP 1 Score: 384.8 bits (987), Expect = 1.383e-117
Identity = 242/661 (36.61%), Postives = 359/661 (54.31%), Query Frame = 2

Query:  254 DEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRK---RTKMERDILAAI-RHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNR--KGHGTAADWWSFGVLMFEMLTGQLPFQGSS----RKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKI--SGWQNIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTK---RDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQG---YDKASDVWSLGVLLFIMLSGKTPFTQNEHD------PPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAM 2164
            DE +  + F+++RVLG G++G+VFLVRK++    G LYAMKVL K ++ VQ RK    TK ER +L AI R+PF+V+LHYAFQ+  K+YL+L+F  GG+LF+ L     F E  V+ Y+AE+ LAL+ LH LGI+YRD+K ENILLD +GHI L+DFGLSK  +  ++  R  SFCGT+EYMAPE++     GH +A DWWS GVL FE+LTG  PF  S     + E    I K +  +P   S+ A+  +  + ++NP  R+G   +   EIK  PFF  INW++L  ++   P+KP  T  DD   F ++FT + P++  C  A  +   +FRG++YVAP+ L+  +  N  +++   +G QNI      + D    L      G++  C+  V  +T + +  K+I  +K    +V   +        H +IV     + ++    ++MEYL G EL  +I       E    +I   L   V ++H+   +H DLKP NI++  ++     L+  DFG A            P YT ++  PE+L       Y  A D++ LG  L+ ML G  P+ QNE D         E+ KR+ + +F     +WE  S   + L+   L  DPA R T + IL   W+ + S+ P   I +
Sbjct:  253 DEAVSLNDFKIIRVLGTGAYGRVFLVRKLTRHDAGKLYAMKVLNKITV-VQKRKTAEHTKTERVVLEAIQRNPFLVSLHYAFQSSSKLYLVLDFANGGELFTHLYHSENFEESRVRVYIAEVVLALEQLHQLGIIYRDIKLENILLDGEGHIVLSDFGLSK-ILTAENEYRAHSFCGTLEYMAPEIIRTGPPGHDSAVDWWSVGVLTFELLTGASPFATSDGQVQQSEISRRIQKEQPMIPSSFSANARDFVLKMLEKNPKRRLGGNHRDASEIKEHPFFNGINWQELRTKRRKAPYKPTLTAEDDVQNFSNEFTDQVPEDPECD-APPSRIRLFRGYTYVAPEHLEQMRRDNHCEIQYFNTGLQNIPC----RPDD-LELGTRTSNGAYGTCHFVVDSSTDLVFLAKIIPLSKFRPSEVDALISCALDTTNHKNIVSYHGTFREKCETWIVMEYLSGPELTASI----RMDEDSCREIFLQLVMAVRHIHSKHFIHGDLKPENIMFENREDRTVKLI--DFGSACYNNRFKSWKDKPRYTLDYAPPEMLADANLVTYSPAVDIYGLGATLYTMLVGHRPYRQNEDDVDHSAAAHHELRKRMRRGTFNQRSMRWESASPAFRHLVSWCLQRDPADRPTLSDILDSEWLQYGSNDPDVDIIL 899

[Close]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Fly
Match: JIL-1 (gene:FBgn0020412 transcript:FBtr0076236)

HSP 1 Score: 384.8 bits (987), Expect = 1.383e-117
Identity = 242/661 (36.61%), Postives = 359/661 (54.31%), Query Frame = 2

Query:  254 DEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRK---RTKMERDILAAI-RHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNR--KGHGTAADWWSFGVLMFEMLTGQLPFQGSS----RKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKI--SGWQNIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTK---RDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQG---YDKASDVWSLGVLLFIMLSGKTPFTQNEHD------PPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAM 2164
            DE +  + F+++RVLG G++G+VFLVRK++    G LYAMKVL K ++ VQ RK    TK ER +L AI R+PF+V+LHYAFQ+  K+YL+L+F  GG+LF+ L     F E  V+ Y+AE+ LAL+ LH LGI+YRD+K ENILLD +GHI L+DFGLSK  +  ++  R  SFCGT+EYMAPE++     GH +A DWWS GVL FE+LTG  PF  S     + E    I K +  +P   S+ A+  +  + ++NP  R+G   +   EIK  PFF  INW++L  ++   P+KP  T  DD   F ++FT + P++  C  A  +   +FRG++YVAP+ L+  +  N  +++   +G QNI      + D    L      G++  C+  V  +T + +  K+I  +K    +V   +        H +IV     + ++    ++MEYL G EL  +I       E    +I   L   V ++H+   +H DLKP NI++  ++     L+  DFG A            P YT ++  PE+L       Y  A D++ LG  L+ ML G  P+ QNE D         E+ KR+ + +F     +WE  S   + L+   L  DPA R T + IL   W+ + S+ P   I +
Sbjct:  253 DEAVSLNDFKIIRVLGTGAYGRVFLVRKLTRHDAGKLYAMKVLNKITV-VQKRKTAEHTKTERVVLEAIQRNPFLVSLHYAFQSSSKLYLVLDFANGGELFTHLYHSENFEESRVRVYIAEVVLALEQLHQLGIIYRDIKLENILLDGEGHIVLSDFGLSK-ILTAENEYRAHSFCGTLEYMAPEIIRTGPPGHDSAVDWWSVGVLTFELLTGASPFATSDGQVQQSEISRRIQKEQPMIPSSFSANARDFVLKMLEKNPKRRLGGNHRDASEIKEHPFFNGINWQELRTKRRKAPYKPTLTAEDDVQNFSNEFTDQVPEDPECD-APPSRIRLFRGYTYVAPEHLEQMRRDNHCEIQYFNTGLQNIPC----RPDD-LELGTRTSNGAYGTCHFVVDSSTDLVFLAKIIPLSKFRPSEVDALISCALDTTNHKNIVSYHGTFREKCETWIVMEYLSGPELTASI----RMDEDSCREIFLQLVMAVRHIHSKHFIHGDLKPENIMFENREDRTVKLI--DFGSACYNNRFKSWKDKPRYTLDYAPPEMLADANLVTYSPAVDIYGLGATLYTMLVGHRPYRQNEDDVDHSAAAHHELRKRMRRGTFNQRSMRWESASPAFRHLVSWCLQRDPADRPTLSDILDSEWLQYGSNDPDVDIIL 899

[Close]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Zebrafish
Match: rps6ka3a (ribosomal protein S6 kinase a, polypeptide 3a [Source:ZFIN;Acc:ZDB-GENE-030219-119])

HSP 1 Score: 858.596 bits (2217), Expect = 0.000e+0
Identity = 443/734 (60.35%), Postives = 533/734 (72.62%), Query Frame = 2

Query:  122 MPLGPVTDSFHISNLNEVEVDEE--FSDNAFSQEE----EATEVNAVDLVDEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKISGWQNIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKALLEKSLPNLAPVANSTLAKRRGQSKPKSST 2305
            MPL    D +    +  +E +++    D++   +E    E +  + V    EK D   FEL +VLGQGSFGKVFLV+K+S P  G LYAMKVLKKA+LKV+DR RTKMERDIL  + HPFIV LHYAFQ EGK+YLIL+FL+GGDLF+RLSKE MFTE+DVKFYLAELALALDHLH LGI+YRDLKPENILLD+DGHIKLTDFGLSKESI  D  N+ +SFCGTVEYMAPEVVNR+GH  +ADWWS+GVLMFEMLTG LPFQG  RKETMTMILKAKL MPQFLS EAQ+LLR LFKRNP NR+G GP G+E IK   FF  I+W  L  ++V PPFKP     DDT  FDS+FT+KTP++SP  P SA A+++FRGFS+VA  V + +Q+    ++ +S          Q  D  Y +KE+IG GS+SVC R V K+TG++YA+K+I   +RD  EEVEIL R+G HP+I+ LK+V+    +V L+ E ++GGELL  IL QK+FSE+EAS +LY +T+TV YLH   VVHRDLKPSNILY  +  NPE++ ICDFGFAKQ RAENGLLMTPCYTANFVAPEVLKKQGYD A D+WSLGVLL+ ML+G TPF     D PEEIL RI    F LTGG W  +S +AKDL+ KMLH DP +R+T  Q+L H WI  +  LP  ++        VKGA+ ATY AL     P L PV  STLA+RRG  K  S+ 
Sbjct:    1 MPLAQCADPWQKLPMGHLENEDDSMIEDDSLVHDEGSVKEISITHHVKEGSEKADPRQFELRKVLGQGSFGKVFLVKKISGPDAGQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHGLGIIYRDLKPENILLDDDGHIKLTDFGLSKESI--DHENKAYSFCGTVEYMAPEVVNRRGHTQSADWWSYGVLMFEMLTGALPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRNLFKRNPGNRLGAGPDGVEGIKRHSFFTRIDWNKLFRKEVPPPFKPAIKKPDDTFYFDSEFTAKTPRDSPGVPPSANAHQLFRGFSFVATGVEEESQSPIQSNINMSSILQSHRSTLQFTD-AYEVKEDIGVGSYSVCKRCVQKSTGMDYAVKIIKKERRDPTEEVEILLRYGQHPNIITLKDVFDDGRSVYLVTELMKGGELLDKILRQKFFSEREASAVLYTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKKQGYDAACDIWSLGVLLYTMLTGFTPFANGPEDTPEEILARIGSGKFSLTGGYWNSVSHDAKDLVSKMLHVDPHKRLTAAQVLRHPWIINKDQLPKYQLNRQDAPHLVKGAMAATYSALNRNVSPVLDPVGCSTLAQRRGLKKLTSTA 731

[Close]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Zebrafish
Match: rps6ka3a (ribosomal protein S6 kinase a, polypeptide 3a [Source:ZFIN;Acc:ZDB-GENE-030219-119])

HSP 1 Score: 857.44 bits (2214), Expect = 0.000e+0
Identity = 444/737 (60.24%), Postives = 535/737 (72.59%), Query Frame = 2

Query:  122 MPLGPVTDSFHISNLNEVEVDEE--FSDNAFSQEE----EATEVNAVDLVDEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQN---ANIEDMKISGWQNIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKALLEKSLPNLAPVANSTLAKRRGQSKPKSST 2305
            MPL    D +    +  +E +++    D++   +E    E +  + V    EK D   FEL +VLGQGSFGKVFLV+K+S P  G LYAMKVLKKA+LKV+DR RTKMERDIL  + HPFIV LHYAFQ EGK+YLIL+FL+GGDLF+RLSKE MFTE+DVKFYLAELALALDHLH LGI+YRDLKPENILLD+DGHIKLTDFGLSKESI  D  N+ +SFCGTVEYMAPEVVNR+GH  +ADWWS+GVLMFEMLTG LPFQG  RKETMTMILKAKL MPQFLS EAQ+LLR LFKRNP NR+G GP G+E IK   FF  I+W  L  ++V PPFKP     DDT  FDS+FT+KTP++SP  P SA A+++FRGFS+VA  V + +Q+   +NI    I    +   ++F      Y +KE+IG GS+SVC R V K+TG++YA+K+I   +RD  EEVEIL R+G HP+I+ LK+V+    +V L+ E ++GGELL  IL QK+FSE+EAS +LY +T+TV YLH   VVHRDLKPSNILY  +  NPE++ ICDFGFAKQ RAENGLLMTPCYTANFVAPEVLKKQGYD A D+WSLGVLL+ ML+G TPF     D PEEIL RI    F LTGG W  +S +AKDL+ KMLH DP +R+T  Q+L H WI  +  LP  ++        VKGA+ ATY AL     P L PV  STLA+RRG  K  S+ 
Sbjct:    1 MPLAQCADPWQKLPMGHLENEDDSMIEDDSLVHDEGSVKEISITHHVKEGSEKADPRQFELRKVLGQGSFGKVFLVKKISGPDAGQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHGLGIIYRDLKPENILLDDDGHIKLTDFGLSKESI--DHENKAYSFCGTVEYMAPEVVNRRGHTQSADWWSYGVLMFEMLTGALPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRNLFKRNPGNRLGAGPDGVEGIKRHSFFTRIDWNKLFRKEVPPPFKPAIKKPDDTFYFDSEFTAKTPRDSPGVPPSANAHQLFRGFSFVATGVEEESQSPIQSNINMSSILQQSHRSTLQFTDA---YEVKEDIGVGSYSVCKRCVQKSTGMDYAVKIIKKERRDPTEEVEILLRYGQHPNIITLKDVFDDGRSVYLVTELMKGGELLDKILRQKFFSEREASAVLYTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKKQGYDAACDIWSLGVLLYTMLTGFTPFANGPEDTPEEILARIGSGKFSLTGGYWNSVSHDAKDLVSKMLHVDPHKRLTAAQVLRHPWIINKDQLPKYQLNRQDAPHLVKGAMAATYSALNRNVSPVLDPVGCSTLAQRRGLKKLTSTA 732

[Close]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Zebrafish
Match: rps6ka1 (ribosomal protein S6 kinase a, polypeptide 1 [Source:ZFIN;Acc:ZDB-GENE-060929-516])

HSP 1 Score: 848.966 bits (2192), Expect = 0.000e+0
Identity = 435/702 (61.97%), Postives = 520/702 (74.07%), Query Frame = 2

Query:  218 EEATEVNAVDLV---DEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKISGW---QNIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKAL-LEKSLPNLAPVANSTLAKRRGQSKPKSS 2302
            EE  E+N   +V    EK D+S FELL+VLGQGSFGKVFLVRKV+ P    LYAMKVL+KA+LKV+DR RTKMERDILA + HPF+V LHYAFQ EGK+YLIL+FL+GGDLF+RLSKE MFTE+DVKFYLAELAL LDHLH LGI+YRDLKPENILLDE+GHIKLTDFGL KE+I  D   + +SFCGTVEYMAPEVVNR+GH  +ADWWSFGVLMFEMLTG LPFQG  RKETM +ILKA+L MPQFLSSEAQ+LLR LFKRNP+NR+G G  G EEIK   FF  I+W  L  R++ PPFKP     DDT  FDS+FTS+TPK+SP  P SA A+++FRGFS+VA  +L+  +    E  K       Q + G      D Y  +KE+IG GSFSVC R +HK T   YA+KVID T  D  EE+EIL R+G HP+I+ LK+VY     V L+ E + GGELL  IL QK+FSE+EAS +L+ +T+TV YLH+  VVHRDLKPSNILY  +  NPE+L ICDFGFAKQ RA+NGLLMTPCYTANFVAPEVLK+QGYD+  D+WSLGVLL+ M++G TPF     D PEEIL RI    F LTGG W+ +S  AKDL+ KMLH DP QR+T  Q+L H WI  R  LP++++  + D   VKGA+ ATY AL   +  P L P+ +S LA+RR +  P +S
Sbjct:   62 EEIKEINITHVVKEGSEKADASQFELLKVLGQGSFGKVFLVRKVTPPDNNQLYAMKVLRKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHGLGIIYRDLKPENILLDEEGHIKLTDFGLCKEAI--DHEKKAYSFCGTVEYMAPEVVNRQGHTHSADWWSFGVLMFEMLTGSLPFQGKDRKETMNLILKARLGMPQFLSSEAQSLLRALFKRNPTNRLGSGSDGAEEIKRHSFFMTIDWNKLFRREIKPPFKPAVARPDDTFYFDSEFTSRTPKDSPGVPPSAGAHQLFRGFSFVATAMLE--EEGKEEPSKPPPHPVVQQLHGKNILFSDGY-VMKEDIGMGSFSVCKRCIHKVTNTEYAVKVIDKTSTDPTEEIEILLRYGQHPNIITLKDVYDNGKQVYLVTELMRGGELLDRILKQKFFSEREASAVLHTITKTVEYLHSQGVVHRDLKPSNILYVDESGNPESLRICDFGFAKQLRADNGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGVLLYTMIAGFTPFANGPEDTPEEILSRIGSGRFTLTGGNWDAVSDAAKDLVSKMLHVDPHQRLTARQVLKHPWIVQRDKLPNSQL-QHQDAKLVKGAMAATYSALKSSQPPPELKPIESSFLAQRRVKKLPSTS 757

[Close]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Zebrafish
Match: rps6ka1 (ribosomal protein S6 kinase a, polypeptide 1 [Source:ZFIN;Acc:ZDB-GENE-060929-516])

HSP 1 Score: 848.581 bits (2191), Expect = 0.000e+0
Identity = 435/702 (61.97%), Postives = 520/702 (74.07%), Query Frame = 2

Query:  218 EEATEVNAVDLV---DEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKISGW---QNIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKAL-LEKSLPNLAPVANSTLAKRRGQSKPKSS 2302
            EE  E+N   +V    EK D+S FELL+VLGQGSFGKVFLVRKV+ P    LYAMKVL+KA+LKV+DR RTKMERDILA + HPF+V LHYAFQ EGK+YLIL+FL+GGDLF+RLSKE MFTE+DVKFYLAELAL LDHLH LGI+YRDLKPENILLDE+GHIKLTDFGL KE+I  D   + +SFCGTVEYMAPEVVNR+GH  +ADWWSFGVLMFEMLTG LPFQG  RKETM +ILKA+L MPQFLSSEAQ+LLR LFKRNP+NR+G G  G EEIK   FF  I+W  L  R++ PPFKP     DDT  FDS+FTS+TPK+SP  P SA A+++FRGFS+VA  +L+  +    E  K       Q + G      D Y  +KE+IG GSFSVC R +HK T   YA+KVID T  D  EE+EIL R+G HP+I+ LK+VY     V L+ E + GGELL  IL QK+FSE+EAS +L+ +T+TV YLH+  VVHRDLKPSNILY  +  NPE+L ICDFGFAKQ RA+NGLLMTPCYTANFVAPEVLK+QGYD+  D+WSLGVLL+ M++G TPF     D PEEIL RI    F LTGG W+ +S  AKDL+ KMLH DP QR+T  Q+L H WI  R  LP++++  + D   VKGA+ ATY AL   +  P L P+ +S LA+RR +  P +S
Sbjct:   59 EEIKEINITHVVKEGSEKADASQFELLKVLGQGSFGKVFLVRKVTPPDNNQLYAMKVLRKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHGLGIIYRDLKPENILLDEEGHIKLTDFGLCKEAI--DHEKKAYSFCGTVEYMAPEVVNRQGHTHSADWWSFGVLMFEMLTGSLPFQGKDRKETMNLILKARLGMPQFLSSEAQSLLRALFKRNPTNRLGSGSDGAEEIKRHSFFMTIDWNKLFRREIKPPFKPAVARPDDTFYFDSEFTSRTPKDSPGVPPSAGAHQLFRGFSFVATAMLE--EEGKEEPSKPPPHPVVQQLHGKNILFSDGY-VMKEDIGMGSFSVCKRCIHKVTNTEYAVKVIDKTSTDPTEEIEILLRYGQHPNIITLKDVYDNGKQVYLVTELMRGGELLDRILKQKFFSEREASAVLHTITKTVEYLHSQGVVHRDLKPSNILYVDESGNPESLRICDFGFAKQLRADNGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGVLLYTMIAGFTPFANGPEDTPEEILSRIGSGRFTLTGGNWDAVSDAAKDLVSKMLHVDPHQRLTARQVLKHPWIVQRDKLPNSQL-QHQDAKLVKGAMAATYSALKSSQPPPELKPIESSFLAQRRVKKLPSTS 754

[Close]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Zebrafish
Match: rps6ka1 (ribosomal protein S6 kinase a, polypeptide 1 [Source:ZFIN;Acc:ZDB-GENE-060929-516])

HSP 1 Score: 848.195 bits (2190), Expect = 0.000e+0
Identity = 441/741 (59.51%), Postives = 534/741 (72.06%), Query Frame = 2

Query:  122 MPLGPVTDSFHISNLNEVEVD-------EEFSDNAFSQEEEATEVNAVDLV---DEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKISGW---QNIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKAL-LEKSLPNLAPVANSTLAKRRGQSKPKSS 2302
            MPL  + + +    L ++E +       +  S +     EE  E+N   +V    EK D+S FELL+VLGQGSFGKVFLVRKV+ P    LYAMKVL+KA+LKV+DR RTKMERDILA + HPF+V LHYAFQ EGK+YLIL+FL+GGDLF+RLSKE MFTE+DVKFYLAELAL LDHLH LGI+YRDLKPENILLDE+GHIKLTDFGL KE+I  D   + +SFCGTVEYMAPEVVNR+GH  +ADWWSFGVLMFEMLTG LPFQG  RKETM +ILKA+L MPQFLSSEAQ+LLR LFKRNP+NR+G G  G EEIK   FF  I+W  L  R++ PPFKP     DDT  FDS+FTS+TPK+SP  P SA A+++FRGFS+VA  +L+  +    E  K       Q + G      D Y  +KE+IG GSFSVC R +HK T   YA+KVID T  D  EE+EIL R+G HP+I+ LK+VY     V L+ E + GGELL  IL QK+FSE+EAS +L+ +T+TV YLH+  VVHRDLKPSNILY  +  NPE+L ICDFGFAKQ RA+NGLLMTPCYTANFVAPEVLK+QGYD+  D+WSLGVLL+ M++G TPF     D PEEIL RI    F LTGG W+ +S  AKDL+ KMLH DP QR+T  Q+L H WI  R  LP++++  + D   VKGA+ ATY AL   +  P L P+ +S LA+RR +  P +S
Sbjct:    1 MPLAQLAEPWPKMELVQLETENGQSTTEDGVSSSVKEDGEEIKEINITHVVKEGSEKADASQFELLKVLGQGSFGKVFLVRKVTPPDNNQLYAMKVLRKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHGLGIIYRDLKPENILLDEEGHIKLTDFGLCKEAI--DHEKKAYSFCGTVEYMAPEVVNRQGHTHSADWWSFGVLMFEMLTGSLPFQGKDRKETMNLILKARLGMPQFLSSEAQSLLRALFKRNPTNRLGSGSDGAEEIKRHSFFMTIDWNKLFRREIKPPFKPAVARPDDTFYFDSEFTSRTPKDSPGVPPSAGAHQLFRGFSFVATAMLE--EEGKEEPSKPPPHPVVQQLHGKNILFSDGY-VMKEDIGMGSFSVCKRCIHKVTNTEYAVKVIDKTSTDPTEEIEILLRYGQHPNIITLKDVYDNGKQVYLVTELMRGGELLDRILKQKFFSEREASAVLHTITKTVEYLHSQGVVHRDLKPSNILYVDESGNPESLRICDFGFAKQLRADNGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGVLLYTMIAGFTPFANGPEDTPEEILSRIGSGRFTLTGGNWDAVSDAAKDLVSKMLHVDPHQRLTARQVLKHPWIVQRDKLPNSQL-QHQDAKLVKGAMAATYSALKSSQPPPELKPIESSFLAQRRVKKLPSTS 735

[Close]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Xenopus
Match: rps6ka1 (ribosomal protein S6 kinase A1 [Source:NCBI gene;Acc:100144704])

HSP 1 Score: 857.825 bits (2215), Expect = 0.000e+0
Identity = 436/705 (61.84%), Postives = 529/705 (75.04%), Query Frame = 2

Query:  191 FSDNAFSQEEEATEVNAVDLVDEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKISGWQNIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKAL-LEKSLPNLAPVANSTLAKRRGQSKPKSS 2302
            FSD    +E   T  + V    EK D SHF LL+VLGQGSFGKVFLVRK++ P    LYAMKVLKKA+LKV+DR RTKMERDILA + HPF+V LHYAFQ EGK+YLIL+FL+GGDLF+RLSKE MFTE+DVKFYLAELAL LDHLHSLGI+YRDLKPENILLDE+GHIKLTDFGLSKE+I  D   + +SFCGTVEYMAPEVVNR+GH  +ADWWS+GVLMFEMLTG LPFQG  RKETMT+ILKAKL MPQFLS+EAQ LLR LFKRNP+NR+G G +G EEIK  PFF  I+W  L  R ++PPFKP  T  DDT  FD++FTS+TPK+SP  P SA A+++FRGFS+VAP +++       ED K +    ++ VK       YT++E IG GS+SVC R VHK T + YA+KVID TKRD  EE+EIL R+G HP+I+ LK+VY + N++ L+ E + GGELL  IL QK+FSE+EA+ +L  + +TV YLH+  VVHRDLKPSNILY  +  NPE++ ICDFGFAKQ RAENGLLMTPCYTANFVAPEVLK+QGYD+  D+WSLG+L++ ML+G TPF     D PEEIL RI    F L GG W  +S  AKDL+ +MLH DP +R+T  Q+L H WIT R  LP +++    D+  VKGA+ ATY AL   K  P L P+ +S LA+RR +  P ++
Sbjct:   30 FSDEVVVKEIPIT--HHVKEGSEKADQSHFVLLKVLGQGSFGKVFLVRKITPPDANQLYAMKVLKKATLKVRDRVRTKMERDILADVHHPFVVRLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAI--DHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSNEAQGLLRSLFKRNPTNRLGSGVEGAEEIKRHPFFSTIDWNKLYRRDMSPPFKPAVTQPDDTYYFDTEFTSRTPKDSPGIPPSAGAHQLFRGFSFVAPVLVE-------EDAKKTSSPPVLSVKNVLFTDVYTVRETIGVGSYSVCKRCVHKGTNMEYAVKVIDKTKRDPSEEIEILRRYGQHPNIITLKDVYEEGNSIYLVTELMRGGELLDRILRQKFFSEREANLVLLTVCKTVEYLHSQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILVYTMLAGYTPFANGPGDTPEEILARIGSGKFTLRGGNWNTVSDSAKDLVSRMLHVDPHRRLTAKQVLQHEWITNRDLLPQSQLN-RQDVHLVKGAMAATYSALNSSKPTPQLQPIKSSILAQRRVKKLPSTT 722

[Close]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Xenopus
Match: rps6ka1 (ribosomal protein S6 kinase A1 [Source:NCBI gene;Acc:100144704])

HSP 1 Score: 851.277 bits (2198), Expect = 0.000e+0
Identity = 430/688 (62.50%), Postives = 521/688 (75.73%), Query Frame = 2

Query:  257 EKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKISGWQNIVGV-----KFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKAL-LEKSLPNLAPVANSTLAKRRGQSKPKSS 2302
            EK D SHF LL+VLGQGSFGKVFLVRK++ P    LYAMKVLKKA+LKV+DR RTKMERDILA + HPF+V LHYAFQ EGK+YLIL+FL+GGDLF+RLSKE MFTE+DVKFYLAELAL LDHLHSLGI+YRDLKPENILLDE+GHIKLTDFGLSKE+I  D   + +SFCGTVEYMAPEVVNR+GH  +ADWWS+GVLMFEMLTG LPFQG  RKETMT+ILKAKL MPQFLS+EAQ LLR LFKRNP+NR+G G +G EEIK  PFF  I+W  L  R ++PPFKP  T  DDT  FD++FTS+TPK+SP  P SA A+++FRGFS+VAP +++       ED K +    ++ V     K       YT++E IG GS+SVC R VHK T + YA+KVID TKRD  EE+EIL R+G HP+I+ LK+VY + N++ L+ E + GGELL  IL QK+FSE+EA+ +L  + +TV YLH+  VVHRDLKPSNILY  +  NPE++ ICDFGFAKQ RAENGLLMTPCYTANFVAPEVLK+QGYD+  D+WSLG+L++ ML+G TPF     D PEEIL RI    F L GG W  +S  AKDL+ +MLH DP +R+T  Q+L H WIT R  LP +++    D+  VKGA+ ATY AL   K  P L P+ +S LA+RR +  P ++
Sbjct:   14 EKADQSHFVLLKVLGQGSFGKVFLVRKITPPDANQLYAMKVLKKATLKVRDRVRTKMERDILADVHHPFVVRLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAI--DHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSNEAQGLLRSLFKRNPTNRLGSGVEGAEEIKRHPFFSTIDWNKLYRRDMSPPFKPAVTQPDDTYYFDTEFTSRTPKDSPGIPPSAGAHQLFRGFSFVAPVLVE-------EDAKKTSSPPVLSVPKTHSKNVLFTDVYTVRETIGVGSYSVCKRCVHKGTNMEYAVKVIDKTKRDPSEEIEILRRYGQHPNIITLKDVYEEGNSIYLVTELMRGGELLDRILRQKFFSEREANLVLLTVCKTVEYLHSQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILVYTMLAGYTPFANGPGDTPEEILARIGSGKFTLRGGNWNTVSDSAKDLVSRMLHVDPHRRLTAKQVLQHEWITNRDLLPQSQLN-RQDVHLVKGAMAATYSALNSSKPTPQLQPIKSSILAQRRVKKLPSTT 691

[Close]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Xenopus
Match: rps6ka1 (ribosomal protein S6 kinase A1 [Source:NCBI gene;Acc:100144704])

HSP 1 Score: 850.892 bits (2197), Expect = 0.000e+0
Identity = 430/688 (62.50%), Postives = 521/688 (75.73%), Query Frame = 2

Query:  257 EKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKISGWQNIVGV-----KFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKAL-LEKSLPNLAPVANSTLAKRRGQSKPKSS 2302
            EK D SHF LL+VLGQGSFGKVFLVRK++ P    LYAMKVLKKA+LKV+DR RTKMERDILA + HPF+V LHYAFQ EGK+YLIL+FL+GGDLF+RLSKE MFTE+DVKFYLAELAL LDHLHSLGI+YRDLKPENILLDE+GHIKLTDFGLSKE+I  D   + +SFCGTVEYMAPEVVNR+GH  +ADWWS+GVLMFEMLTG LPFQG  RKETMT+ILKAKL MPQFLS+EAQ LLR LFKRNP+NR+G G +G EEIK  PFF  I+W  L  R ++PPFKP  T  DDT  FD++FTS+TPK+SP  P SA A+++FRGFS+VAP +++       ED K +    ++ V     K       YT++E IG GS+SVC R VHK T + YA+KVID TKRD  EE+EIL R+G HP+I+ LK+VY + N++ L+ E + GGELL  IL QK+FSE+EA+ +L  + +TV YLH+  VVHRDLKPSNILY  +  NPE++ ICDFGFAKQ RAENGLLMTPCYTANFVAPEVLK+QGYD+  D+WSLG+L++ ML+G TPF     D PEEIL RI    F L GG W  +S  AKDL+ +MLH DP +R+T  Q+L H WIT R  LP +++    D+  VKGA+ ATY AL   K  P L P+ +S LA+RR +  P ++
Sbjct:   55 EKADQSHFVLLKVLGQGSFGKVFLVRKITPPDANQLYAMKVLKKATLKVRDRVRTKMERDILADVHHPFVVRLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAI--DHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSNEAQGLLRSLFKRNPTNRLGSGVEGAEEIKRHPFFSTIDWNKLYRRDMSPPFKPAVTQPDDTYYFDTEFTSRTPKDSPGIPPSAGAHQLFRGFSFVAPVLVE-------EDAKKTSSPPVLSVPKTHSKNVLFTDVYTVRETIGVGSYSVCKRCVHKGTNMEYAVKVIDKTKRDPSEEIEILRRYGQHPNIITLKDVYEEGNSIYLVTELMRGGELLDRILRQKFFSEREANLVLLTVCKTVEYLHSQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILVYTMLAGYTPFANGPGDTPEEILARIGSGKFTLRGGNWNTVSDSAKDLVSRMLHVDPHRRLTAKQVLQHEWITNRDLLPQSQLN-RQDVHLVKGAMAATYSALNSSKPTPQLQPIKSSILAQRRVKKLPSTT 732

[Close]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Xenopus
Match: rps6ka1 (ribosomal protein S6 kinase A1 [Source:NCBI gene;Acc:100144704])

HSP 1 Score: 850.892 bits (2197), Expect = 0.000e+0
Identity = 430/691 (62.23%), Postives = 522/691 (75.54%), Query Frame = 2

Query:  248 LVDEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKISGWQNIVGV-----KFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKAL-LEKSLPNLAPVANSTLAKRRGQSKPKSS 2302
            +  EK D SHF LL+VLGQGSFGKVFLVRK++ P    LYAMKVLKKA+LKV+DR RTKMERDILA + HPF+V LHYAFQ EGK+YLIL+FL+GGDLF+RLSKE MFTE+DVKFYLAELAL LDHLHSLGI+YRDLKPENILLDE+GHIKLTDFGLSKE+I  D   + +SFCGTVEYMAPEVVNR+GH  +ADWWS+GVLMFEMLTG LPFQG  RKETMT+ILKAKL MPQFLS+EAQ LLR LFKRNP+NR+G G +G EEIK  PFF  I+W  L  R ++PPFKP  T  DDT  FD++FTS+TPK+SP  P SA A+++FRGFS+VAP +++       ED K +    ++ V     K       YT++E IG GS+SVC R VHK T + YA+KVID TKRD  EE+EIL R+G HP+I+ LK+VY + N++ L+ E + GGELL  IL QK+FSE+EA+ +L  + +TV YLH+  VVHRDLKPSNILY  +  NPE++ ICDFGFAKQ RAENGLLMTPCYTANFVAPEVLK+QGYD+  D+WSLG+L++ ML+G TPF     D PEEIL RI    F L GG W  +S  AKDL+ +MLH DP +R+T  Q+L H WIT R  LP +++    D+  VKGA+ ATY AL   K  P L P+ +S LA+RR +  P ++
Sbjct:    1 MCSEKADQSHFVLLKVLGQGSFGKVFLVRKITPPDANQLYAMKVLKKATLKVRDRVRTKMERDILADVHHPFVVRLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAI--DHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSNEAQGLLRSLFKRNPTNRLGSGVEGAEEIKRHPFFSTIDWNKLYRRDMSPPFKPAVTQPDDTYYFDTEFTSRTPKDSPGIPPSAGAHQLFRGFSFVAPVLVE-------EDAKKTSSPPVLSVPKTHSKNVLFTDVYTVRETIGVGSYSVCKRCVHKGTNMEYAVKVIDKTKRDPSEEIEILRRYGQHPNIITLKDVYEEGNSIYLVTELMRGGELLDRILRQKFFSEREANLVLLTVCKTVEYLHSQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILVYTMLAGYTPFANGPGDTPEEILARIGSGKFTLRGGNWNTVSDSAKDLVSRMLHVDPHRRLTAKQVLQHEWITNRDLLPQSQLN-RQDVHLVKGAMAATYSALNSSKPTPQLQPIKSSILAQRRVKKLPSTT 681

[Close]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Xenopus
Match: rps6ka1 (ribosomal protein S6 kinase A1 [Source:NCBI gene;Acc:100144704])

HSP 1 Score: 850.121 bits (2195), Expect = 0.000e+0
Identity = 430/688 (62.50%), Postives = 521/688 (75.73%), Query Frame = 2

Query:  257 EKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKISGWQNIVGV-----KFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKAL-LEKSLPNLAPVANSTLAKRRGQSKPKSS 2302
            EK D SHF LL+VLGQGSFGKVFLVRK++ P    LYAMKVLKKA+LKV+DR RTKMERDILA + HPF+V LHYAFQ EGK+YLIL+FL+GGDLF+RLSKE MFTE+DVKFYLAELAL LDHLHSLGI+YRDLKPENILLDE+GHIKLTDFGLSKE+I  D   + +SFCGTVEYMAPEVVNR+GH  +ADWWS+GVLMFEMLTG LPFQG  RKETMT+ILKAKL MPQFLS+EAQ LLR LFKRNP+NR+G G +G EEIK  PFF  I+W  L  R ++PPFKP  T  DDT  FD++FTS+TPK+SP  P SA A+++FRGFS+VAP +++       ED K +    ++ V     K       YT++E IG GS+SVC R VHK T + YA+KVID TKRD  EE+EIL R+G HP+I+ LK+VY + N++ L+ E + GGELL  IL QK+FSE+EA+ +L  + +TV YLH+  VVHRDLKPSNILY  +  NPE++ ICDFGFAKQ RAENGLLMTPCYTANFVAPEVLK+QGYD+  D+WSLG+L++ ML+G TPF     D PEEIL RI    F L GG W  +S  AKDL+ +MLH DP +R+T  Q+L H WIT R  LP +++    D+  VKGA+ ATY AL   K  P L P+ +S LA+RR +  P ++
Sbjct:   56 EKADQSHFVLLKVLGQGSFGKVFLVRKITPPDANQLYAMKVLKKATLKVRDRVRTKMERDILADVHHPFVVRLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAI--DHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSNEAQGLLRSLFKRNPTNRLGSGVEGAEEIKRHPFFSTIDWNKLYRRDMSPPFKPAVTQPDDTYYFDTEFTSRTPKDSPGIPPSAGAHQLFRGFSFVAPVLVE-------EDAKKTSSPPVLSVPKTHSKNVLFTDVYTVRETIGVGSYSVCKRCVHKGTNMEYAVKVIDKTKRDPSEEIEILRRYGQHPNIITLKDVYEEGNSIYLVTELMRGGELLDRILRQKFFSEREANLVLLTVCKTVEYLHSQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILVYTMLAGYTPFANGPGDTPEEILARIGSGKFTLRGGNWNTVSDSAKDLVSRMLHVDPHRRLTAKQVLQHEWITNRDLLPQSQLN-RQDVHLVKGAMAATYSALNSSKPTPQLQPIKSSILAQRRVKKLPSTT 733

[Close]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Mouse
Match: Rps6ka1 (ribosomal protein S6 kinase polypeptide 1 [Source:MGI Symbol;Acc:MGI:104558])

HSP 1 Score: 854.358 bits (2206), Expect = 0.000e+0
Identity = 440/720 (61.11%), Postives = 531/720 (73.75%), Query Frame = 2

Query:  158 SNLNEVEVDEEF---SDNAFSQEEEATEVNAVDLVDEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKI-SGWQNIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKAL-LEKSLPNLAPVANSTLAKRRGQSKPKSS 2302
            ++   VE D  F    D A  +E   T  + V    EK D S FELL+VLGQGSFGKVFLVRKV+ P  G LYAMKVLKKA+LKV+DR RTKMERDILA + HPF+V LHYAFQ EGK+YLIL+FL+GGDLF+RLSKE MFTE+DVKFYLAELAL LDHLHSLGI+YRDLKPENILLDE+GHIKLTDFGLSKE+I  D   + +SFCGTVEYMAPEVVNR+GH  +ADWWS+GVLMFEMLTG LPFQG  RKETMT+ILKAKL MPQFLS+EAQ+LLR LFKRNP+NR+G GP G EEIK   F+  I+W  L  R++ PPFKP     DDT  FD++FTS+TP++SP  P SA A+++FRGFS+VA  +++           + S  Q + G      D Y  +KE IG GS+SVC R VHK T + YA+KVID +KRD  EE+EIL R+G HP+I+ LK+VY     V L+ E + GGELL  IL QK+FSE+EAS +L+ +++TV YLH+  VVHRDLKPSNILY  +  NPE L ICDFGFAKQ RAENGLLMTPCYTANFVAPEVLK+QGYD+  D+WSLG+LL+ ML+G TPF     D PEEIL RI    F L+GG W  +S  AKDL+ KMLH DP QR+T  Q+L H WIT +  LP ++++ + DL  VKGA+ ATY AL   K  P L P+ +S LA+RR +  P ++
Sbjct:    5 ADFPRVERDSGFYPRKDEAILKEISIT--HHVKAGSEKADPSQFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAI--DHEKKAYSFCGTVEYMAPEVVNRQGHTHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHIFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPRDSPGIPPSAGAHQLFRGFSFVATGLMEDDGKPRTTQAPLHSVVQQLHGKNLVFSDGY-VVKETIGVGSYSVCKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTISKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWITQKDKLPQSQLS-HQDLQLVKGAMAATYSALNSSKPTPQLKPIESSILAQRRVRKLPSTT 718

[Close]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Mouse
Match: Rps6ka1 (ribosomal protein S6 kinase polypeptide 1 [Source:MGI Symbol;Acc:MGI:104558])

HSP 1 Score: 853.973 bits (2205), Expect = 0.000e+0
Identity = 437/705 (61.99%), Postives = 526/705 (74.61%), Query Frame = 2

Query:  194 SDNAFSQEEEATEVNAVDLVDEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKI-SGWQNIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKAL-LEKSLPNLAPVANSTLAKRRGQSKPKSS 2302
            SD A  +E   T  + V    EK D S FELL+VLGQGSFGKVFLVRKV+ P  G LYAMKVLKKA+LKV+DR RTKMERDILA + HPF+V LHYAFQ EGK+YLIL+FL+GGDLF+RLSKE MFTE+DVKFYLAELAL LDHLHSLGI+YRDLKPENILLDE+GHIKLTDFGLSKE+I  D   + +SFCGTVEYMAPEVVNR+GH  +ADWWS+GVLMFEMLTG LPFQG  RKETMT+ILKAKL MPQFLS+EAQ+LLR LFKRNP+NR+G GP G EEIK   F+  I+W  L  R++ PPFKP     DDT  FD++FTS+TP++SP  P SA A+++FRGFS+VA  +++           + S  Q + G      D Y  +KE IG GS+SVC R VHK T + YA+KVID +KRD  EE+EIL R+G HP+I+ LK+VY     V L+ E + GGELL  IL QK+FSE+EAS +L+ +++TV YLH+  VVHRDLKPSNILY  +  NPE L ICDFGFAKQ RAENGLLMTPCYTANFVAPEVLK+QGYD+  D+WSLG+LL+ ML+G TPF     D PEEIL RI    F L+GG W  +S  AKDL+ KMLH DP QR+T  Q+L H WIT +  LP ++++ + DL  VKGA+ ATY AL   K  P L P+ +S LA+RR +  P ++
Sbjct:   42 SDEAILKEISIT--HHVKAGSEKADPSQFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAI--DHEKKAYSFCGTVEYMAPEVVNRQGHTHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHIFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPRDSPGIPPSAGAHQLFRGFSFVATGLMEDDGKPRTTQAPLHSVVQQLHGKNLVFSDGY-VVKETIGVGSYSVCKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTISKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWITQKDKLPQSQLS-HQDLQLVKGAMAATYSALNSSKPTPQLKPIESSILAQRRVRKLPSTT 740

[Close]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Mouse
Match: Rps6ka1 (ribosomal protein S6 kinase polypeptide 1 [Source:MGI Symbol;Acc:MGI:104558])

HSP 1 Score: 853.588 bits (2204), Expect = 0.000e+0
Identity = 442/736 (60.05%), Postives = 539/736 (73.23%), Query Frame = 2

Query:  101 CNIKSKVMPLGPVTDSFHISNLNEVEVDEEFSDNAFSQEEEATEVNAVDLVDEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKI-SGWQNIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKAL-LEKSLPNLAPVANSTLAKRRGQSKPKSS 2302
            C  ++  +  GP T + H  +L  + + +   D A  +E   T  + V    EK D S FELL+VLGQGSFGKVFLVRKV+ P  G LYAMKVLKKA+LKV+DR RTKMERDILA + HPF+V LHYAFQ EGK+YLIL+FL+GGDLF+RLSKE MFTE+DVKFYLAELAL LDHLHSLGI+YRDLKPENILLDE+GHIKLTDFGLSKE+I  D   + +SFCGTVEYMAPEVVNR+GH  +ADWWS+GVLMFEMLTG LPFQG  RKETMT+ILKAKL MPQFLS+EAQ+LLR LFKRNP+NR+G GP G EEIK   F+  I+W  L  R++ PPFKP     DDT  FD++FTS+TP++SP  P SA A+++FRGFS+VA  +++           + S  Q + G      D Y  +KE IG GS+SVC R VHK T + YA+KVID +KRD  EE+EIL R+G HP+I+ LK+VY     V L+ E + GGELL  IL QK+FSE+EAS +L+ +++TV YLH+  VVHRDLKPSNILY  +  NPE L ICDFGFAKQ RAENGLLMTPCYTANFVAPEVLK+QGYD+  D+WSLG+LL+ ML+G TPF     D PEEIL RI    F L+GG W  +S  AKDL+ KMLH DP QR+T  Q+L H WIT +  LP ++++ + DL  VKGA+ ATY AL   K  P L P+ +S LA+RR +  P ++
Sbjct:   10 CPGRAPRLQRGPHT-THHTPHLPALSLCQ---DEAILKEISIT--HHVKAGSEKADPSQFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAI--DHEKKAYSFCGTVEYMAPEVVNRQGHTHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHIFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPRDSPGIPPSAGAHQLFRGFSFVATGLMEDDGKPRTTQAPLHSVVQQLHGKNLVFSDGY-VVKETIGVGSYSVCKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTISKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWITQKDKLPQSQLS-HQDLQLVKGAMAATYSALNSSKPTPQLKPIESSILAQRRVRKLPSTT 735

[Close]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Mouse
Match: Rps6ka1 (ribosomal protein S6 kinase polypeptide 1 [Source:MGI Symbol;Acc:MGI:104558])

HSP 1 Score: 853.203 bits (2203), Expect = 0.000e+0
Identity = 431/684 (63.01%), Postives = 518/684 (75.73%), Query Frame = 2

Query:  257 EKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKI-SGWQNIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKAL-LEKSLPNLAPVANSTLAKRRGQSKPKSS 2302
            EK D S FELL+VLGQGSFGKVFLVRKV+ P  G LYAMKVLKKA+LKV+DR RTKMERDILA + HPF+V LHYAFQ EGK+YLIL+FL+GGDLF+RLSKE MFTE+DVKFYLAELAL LDHLHSLGI+YRDLKPENILLDE+GHIKLTDFGLSKE+I  D   + +SFCGTVEYMAPEVVNR+GH  +ADWWS+GVLMFEMLTG LPFQG  RKETMT+ILKAKL MPQFLS+EAQ+LLR LFKRNP+NR+G GP G EEIK   F+  I+W  L  R++ PPFKP     DDT  FD++FTS+TP++SP  P SA A+++FRGFS+VA  +++           + S  Q + G      D Y  +KE IG GS+SVC R VHK T + YA+KVID +KRD  EE+EIL R+G HP+I+ LK+VY     V L+ E + GGELL  IL QK+FSE+EAS +L+ +++TV YLH+  VVHRDLKPSNILY  +  NPE L ICDFGFAKQ RAENGLLMTPCYTANFVAPEVLK+QGYD+  D+WSLG+LL+ ML+G TPF     D PEEIL RI    F L+GG W  +S  AKDL+ KMLH DP QR+T  Q+L H WIT +  LP ++++ + DL  VKGA+ ATY AL   K  P L P+ +S LA+RR +  P ++
Sbjct:   55 EKADPSQFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAI--DHEKKAYSFCGTVEYMAPEVVNRQGHTHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHIFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPRDSPGIPPSAGAHQLFRGFSFVATGLMEDDGKPRTTQAPLHSVVQQLHGKNLVFSDGY-VVKETIGVGSYSVCKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTISKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWITQKDKLPQSQLS-HQDLQLVKGAMAATYSALNSSKPTPQLKPIESSILAQRRVRKLPSTT 734

[Close]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Mouse
Match: Rps6ka3 (ribosomal protein S6 kinase polypeptide 3 [Source:MGI Symbol;Acc:MGI:104557])

HSP 1 Score: 845.884 bits (2184), Expect = 0.000e+0
Identity = 431/686 (62.83%), Postives = 510/686 (74.34%), Query Frame = 2

Query:  257 EKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKISGWQNIVGVKFQKVDHY---YTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKALLEKSLPNLAPVANSTLAKRRGQSKPKSST 2305
            EK D S FELL+VLGQGSFGKVFLV+K+S      LYAMKVLKKA+LKV+DR RTKMERDIL  + HPFIV LHYAFQ EGK+YLIL+FL+GGDLF+RLSKE MFTE+DVKFYLAELALALDHLHSLGI+YRDLKPENILLDE+GHIKLTDFGLSKESI  D   + +SFCGTVEYMAPEVVNR+GH  +ADWWSFGVLMFEMLTG LPFQG  RKETMTMILKAKL MPQFLS EAQ+LLR+LFKRNP+NR+G GP G+EEIK   FF  I+W  L  R++ PPFKP     +DT  FD +FT+KTPK+SP  P SA A+++FRGFS+VA      +Q      M+  G  +IV    +    +   Y +KE+IG GS+SVC R +HK T + +A+K+ID +KRD  EE+EIL R+G HP+I+ LK+VY     V ++ E ++GGELL  IL QK+FSE+EAS +L+ +T+TV YLH   VVHRDLKPSNILY  +  NPE++ ICDFGFAKQ RAENGLLMTPCYTANFVAPEVLK+QGYD A D+WSLGVLL+ ML+G TPF     D PEEIL RI    F L+GG W  +S  AKDL+ KMLH DP QR+T   +L H WI     LP  ++        VKGA+ ATY AL     P L PV  STLA+RRG  K  S+ 
Sbjct:   61 EKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESI--DHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQA-----MQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTA 739

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BLAST of Ribosomal protein S6 kinase vs. UniProt/SwissProt
Match: sp|P18652|KS6AA_CHICK (Ribosomal protein S6 kinase 2 alpha OS=Gallus gallus OX=9031 GN=RPS6KA PE=2 SV=1)

HSP 1 Score: 858.596 bits (2217), Expect = 0.000e+0
Identity = 437/712 (61.38%), Postives = 532/712 (74.72%), Query Frame = 2

Query:  179 VDEEFSDNAFSQEEEATEVNAVDLV---DEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKISGWQNIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKAL-LEKSLPNLAPVANSTLAKRRGQSKPKSS 2302
            V+++  D+    E    E+N    V    EK D S FELL+VLGQGSFGKVFLVRK++ P    LYAMKVLKKA+LKV+DR RTK+ERDILA + HPF+V LHYAFQ EGK+YLIL+FL+GGDLF+RLSKE MFTE+DVKFYLAELAL LDHLHSLGI+YRDLKPENILLDE+GHIKLTDFGLSKE+I  D   + +SFCGTVEYMAPEVVNR+GH  +ADWWS+GVLMFEMLTG LPFQG  RKETMT+ILKAKL MPQFLS+EAQ+LLR LFKRNP+NR+G GP G EEIK  PF+  I+W  L  R++ PPFKP     DDT  FD++FTS+TPK+SP  P SA A+++FRGFS+VA  +++ ++    +    S  Q + G   Q  D Y  +KE IG GS+SVC R +HKTT + YA+KVID +KRD  EE+EIL R+G HP+I+ LK+VY     V L+ E + GGELL  IL QK+FSE+EAS +L+ + +TV YLH+  VVHRDLKPSNILY  +  NPE++ ICDFGFAKQ RAENGLLMTPCYTANFVAPEVLK+QGYD+  D+WSLGVLL+ ML+G TPF     D PEEIL RI    F + GG W+ IS  AKDL+ KMLH DP QR+T  Q+L H WIT + SLP +++    D+  VKGA+ ATY AL   K  P L P+ +S LA+RR +  P ++
Sbjct:   44 VEKDLVDSTDKGEGVVKEINITHHVKEGSEKADPSQFELLKVLGQGSFGKVFLVRKITPPDSNHLYAMKVLKKATLKVRDRVRTKIERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAI--DHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSAEAQSLLRALFKRNPANRLGSGPDGAEEIKRHPFYSTIDWNKLYRREIKPPFKPAVGQPDDTFYFDTEFTSRTPKDSPGIPPSAGAHQLFRGFSFVATGLMEDSKVKPAQPPLHSVVQQLHGKNIQFSDGY-VVKEAIGVGSYSVCKRCIHKTTNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKYVYLVTELMRGGELLDKILRQKFFSEREASSVLHTICKTVEYLHSQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGVLLYTMLAGCTPFANGPSDTPEEILTRIGGGKFSVNGGNWDTISDVAKDLVSKMLHVDPHQRLTAKQVLQHPWITQKDSLPQSQLNYQ-DVQLVKGAMAATYSALNSSKPSPQLKPIESSILAQRRVKKLPSTT 751

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BLAST of Ribosomal protein S6 kinase vs. UniProt/SwissProt
Match: sp|Q63531|KS6A1_RAT (Ribosomal protein S6 kinase alpha-1 OS=Rattus norvegicus OX=10116 GN=Rps6ka1 PE=1 SV=1)

HSP 1 Score: 858.596 bits (2217), Expect = 0.000e+0
Identity = 435/697 (62.41%), Postives = 523/697 (75.04%), Query Frame = 2

Query:  218 EEATEVNAVDLVDEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKI-SGWQNIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKAL-LEKSLPNLAPVANSTLAKRRGQSKPKSS 2302
            +E +  + V    EK D SHFELL+VLGQGSFGKVFLVRKV+ P  G LYAMKVLKKA+LKV+DR RTKMERDILA + HPF+V LHYAFQ EGK+YLIL+FL+GGDLF+RLSKE MFTE+DVKFYLAELAL LDHLHSLGI+YRDLKPENILLDE+GHIKLTDFGLSKE+I  D   + +SFCGTVEYMAPEVVNR+GH  +ADWWS+GVLMFEMLTG LPFQG  RKETMT+ILKAKL MPQFLS+EAQ+LLR LFKRNP+NR+G GP G EEIK   F+  I+W  L  R++ PPFKP     DDT  FD++FTS+TP++SP  P SA A+++FRGFS+VA  +++           + S  Q + G      D Y  +KE IG GS+SVC R VHK T + YA+KVID +KRD  EE+EIL R+G HP+I+ LK+VY     V L+ E + GGELL  IL QK+FSE+EAS +LY +++TV YLH+  VVHRDLKPSNILY  +  NPE L ICDFGFAKQ RAENGLLMTPCYTANFVAPEVLK+QGYD+  D+WSLGVLL+ ML+G TPF     D PEEIL RI    F L+GG W  +S  AKDL+ KMLH DP QR+T  Q+L H WIT +  LP ++++ + DL  VKG + ATY AL   K  P L P+ +S LA+RR +  P ++
Sbjct:   42 KEISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDNGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAI--DHEKKAYSFCGTVEYMAPEVVNRQGHTHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHIFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPRDSPGIPPSAGAHQLFRGFSFVATGLMEDDSKPRATQAPLHSVVQQLHGKNLVFSDGY-IVKETIGVGSYSVCKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDSKHVYLVTELMRGGELLDKILRQKFFSEREASFVLYTISKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGVLLYTMLAGYTPFANGPSDTPEEILTRISSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWITQKDKLPQSQLS-HQDLQLVKGGMAATYSALSSSKPTPQLKPIESSILAQRRVRKLPSTT 734

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BLAST of Ribosomal protein S6 kinase vs. UniProt/SwissProt
Match: sp|Q15418|KS6A1_HUMAN (Ribosomal protein S6 kinase alpha-1 OS=Homo sapiens OX=9606 GN=RPS6KA1 PE=1 SV=2)

HSP 1 Score: 852.432 bits (2201), Expect = 0.000e+0
Identity = 433/697 (62.12%), Postives = 522/697 (74.89%), Query Frame = 2

Query:  218 EEATEVNAVDLVDEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKI-SGWQNIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKAL-LEKSLPNLAPVANSTLAKRRGQSKPKSS 2302
            +E +  + V    EK D SHFELL+VLGQGSFGKVFLVRKV+ P  G LYAMKVLKKA+LKV+DR RTKMERDILA + HPF+V LHYAFQ EGK+YLIL+FL+GGDLF+RLSKE MFTE+DVKFYLAELAL LDHLHSLGI+YRDLKPENILLDE+GHIKLTDFGLSKE+I  D   + +SFCGTVEYMAPEVVNR+GH  +ADWWS+GVLMFEMLTG LPFQG  RKETMT+ILKAKL MPQFLS+EAQ+LLR LFKRNP+NR+G GP G EEIK   F+  I+W  L  R++ PPFKP     DDT  FD++FTS+TPK+SP  P SA A+++FRGFS+VA  +++           + S  Q + G      D Y  +KE IG GS+S C R VHK T + YA+KVID +KRD  EE+EIL R+G HP+I+ LK+VY     V L+ E + GGELL  IL QK+FSE+EAS +L+ + +TV YLH+  VVHRDLKPSNILY  +  NPE L ICDFGFAKQ RAENGLLMTPCYTANFVAPEVLK+QGYD+  D+WSLG+LL+ ML+G TPF     D PEEIL RI    F L+GG W  +S  AKDL+ KMLH DP QR+T  Q+L H W+T +  LP ++++ + DL  VKGA+ ATY AL   K  P L P+ +S LA+RR +  P ++
Sbjct:   42 KEISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAI--DHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDSPGIPPSAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKNLVFSDGY-VVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQLS-HQDLQLVKGAMAATYSALNSSKPTPQLKPIESSILAQRRVRKLPSTT 734

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BLAST of Ribosomal protein S6 kinase vs. UniProt/SwissProt
Match: sp|P10665|KS6AA_XENLA (Ribosomal protein S6 kinase 2 alpha OS=Xenopus laevis OX=8355 GN=rps6ka PE=1 SV=1)

HSP 1 Score: 848.195 bits (2190), Expect = 0.000e+0
Identity = 437/734 (59.54%), Postives = 536/734 (73.02%), Query Frame = 2

Query:  170 EVEVDEEFSDNAFSQEEEATEVNAVDLV--------------DEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKISGWQNIVGVK--------FQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKAL-LEKSLPNLAPVANSTLAKRRGQSKPKSS 2302
            EV V  E  +N     EE     + D V               EK D S F LL+VLGQGSFGKVFLVRK++ P    LYAMKVLKKA+LKV+DR RTKMERDILA + HPF+V LHYAFQ EGK+YLIL+FL+GGDLF+RLSKE MFTE+DVKFYLAELAL LDHLHSLGI+YRDLKPENILLDE+GHIKLTDFGLSKE+I  D   + +SFCGTVEYMAPEVVNR+GH  +ADWWS+GVLMFEMLTG LPFQG  RKETMT+ILKAKL MPQFLS+EAQ+LLR LFKRNP+NR+G   +G EEIK QPFF  I+W  L  R+++PPFKP  T  DDT  FD++FTS+TPK+SP  P SA A+++FRGFS+VAP +++       ED K +    ++ V         F  V   YT++E IG GS+SVC R VHK T + YA+KVID TKRD  EE+EIL R+G HP+I+ LK+VY + N++ ++ E + GGELL  IL QK+FSE+EAS +L+ + +TV  LH+  VVHRDLKPSNILY  +  +PE++ ICDFGFAKQ RA+NGLLMTPCYTANFVAPEVLK+QGYD+  D+WSLG+LL+ ML+G TPF     D PEEIL RI    F L GG W  +S+ AKDL+ +MLH DP +R+T  Q+L H WIT R +LP +++    D+  VKGA+ ATY AL   K  P L P+ +S LA+RR +  P ++
Sbjct:   12 EVAVVHEDPENGHGSPEEGGRHTSKDEVVVKEFPITHHVKEGSEKADQSDFVLLKVLGQGSFGKVFLVRKITPPDANQLYAMKVLKKATLKVRDRVRTKMERDILADVHHPFVVRLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAI--DHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSNEAQSLLRALFKRNPTNRLGSAMEGAEEIKRQPFFSTIDWNKLFRREMSPPFKPAVTQADDTYYFDTEFTSRTPKDSPGIPPSAGAHQLFRGFSFVAPALVE-------EDAKKTSSPPVLSVPKTHSKNILFMDV---YTVRETIGVGSYSVCKRCVHKGTNMEYAVKVIDKTKRDPSEEIEILRRYGQHPNIIALKDVYKEGNSIYVVTELMRGGELLDRILRQKFFSEREASSVLFTVCKTVENLHSQGVVHRDLKPSNILYVDESGDPESIRICDFGFAKQLRADNGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGLGDTPEEILARIGSGKFTLRGGNWNTVSAAAKDLVSRMLHVDPHKRLTAKQVLQHEWITKRDALPQSQLN-RQDVHLVKGAMAATYSALNSSKPTPLLQPIKSSILAQRRVKKLPSTT 732

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BLAST of Ribosomal protein S6 kinase vs. UniProt/SwissProt
Match: sp|P51812|KS6A3_HUMAN (Ribosomal protein S6 kinase alpha-3 OS=Homo sapiens OX=9606 GN=RPS6KA3 PE=1 SV=1)

HSP 1 Score: 847.04 bits (2187), Expect = 0.000e+0
Identity = 441/746 (59.12%), Postives = 529/746 (70.91%), Query Frame = 2

Query:  122 MPLGPVTDSFHI----SNLNEVEVDEEFSDNAFSQEEEATEVNAVDLVD-----------EKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKISGWQNIVGVKFQKVDHY---YTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKALLEKSLPNLAPVANSTLAKRRGQSKPKSST 2305
            MPL  + D +      S  +  E  ++  D    +EE   +   V + +           EK D S FELL+VLGQGSFGKVFLV+K+S      LYAMKVLKKA+LKV+DR RTKMERDIL  + HPFIV LHYAFQ EGK+YLIL+FL+GGDLF+RLSKE MFTE+DVKFYLAELALALDHLHSLGI+YRDLKPENILLDE+GHIKLTDFGLSKESI  D   + +SFCGTVEYMAPEVVNR+GH  +ADWWSFGVLMFEMLTG LPFQG  RKETMTMILKAKL MPQFLS EAQ+LLR+LFKRNP+NR+G GP G+EEIK   FF  I+W  L  R++ PPFKP     +DT  FD +FT+KTPK+SP  P SA A+++FRGFS+VA      +Q      M+  G  +IV    +    +   Y +KE+IG GS+SVC R +HK T + +A+K+ID +KRD  EE+EIL R+G HP+I+ LK+VY     V ++ E ++GGELL  IL QK+FSE+EAS +L+ +T+TV YLH   VVHRDLKPSNILY  +  NPE++ ICDFGFAKQ RAENGLLMTPCYTANFVAPEVLK+QGYD A D+WSLGVLL+ ML+G TPF     D PEEIL RI    F L+GG W  +S  AKDL+ KMLH DP QR+T   +L H WI     LP  ++        VKGA+ ATY AL     P L PV  STLA+RRG  K  S+ 
Sbjct:    1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESI--DHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQA-----MQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTA 739

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BLAST of Ribosomal protein S6 kinase vs. TrEMBL
Match: A0A2C9JCF0 (Ribosomal protein S6 kinase OS=Biomphalaria glabrata OX=6526 GN=106078255 PE=3 SV=1)

HSP 1 Score: 893.649 bits (2308), Expect = 0.000e+0
Identity = 446/705 (63.26%), Postives = 541/705 (76.74%), Query Frame = 2

Query:  212 QEEEATEVNAVDLVDEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKISGWQNIV---GVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKALLEKSL--PNLAPVANSTLAKRRGQSKPKSSTEI 2311
            + E   E+  V    EK D SHFELL+VLGQGSFGKVFLVRK++ P  G LYAMKVLKKA+LKV+DR+RTKMERDILA + HPFIV LHYAFQ EGK+YLILEFL+GGDLF+RLSKE MFTE+DVKFYLAELALALDHLHSLGI+YRDLKPENILLD +GHIKLTDFGLSKESI+ +  N+T+SFCGTVEYMAPEVVNRKGHGT ADWWS+GVLMFEMLTG LPFQG++RKETMT ILKAKL MP FLS+EAQ+LLR LFKRNP+NR+G  P G+EEIK  PFF  INW  L  R++ PPFKP     DD   FD +FTSKTPK+SP  P SATA+E+FRGFS++AP +L+        D  +    N+    GVK       Y LKE+IG GS+SVC R +HK +G ++A+K++D  KRD  EEVEIL RFG HP+++ L++VY   N V L+ E + GGELL  IL QK+FSE+EAS +L ++ +TV YLH+N VVHRDLKPSNILY+    +P++L ICDFGFAKQ RAENGLLMTPCYTANFVAPEVLK+QGYD + DVWSLGVLL+ ML+G TPF    +D P +IL RI +  F L GG W+ +S +AK+L+ +MLH DP  R+T +Q+L+H WI+ R SLP  ++ +  D   VKG+V AT+KAL  ++     L PV  S LA+RRG+ +PKSSTE+
Sbjct:   33 ESENEVEITNVSKSGEKADPSHFELLKVLGQGSFGKVFLVRKITLPDAGTLYAMKVLKKATLKVRDRQRTKMERDILADVNHPFIVRLHYAFQTEGKLYLILEFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDTEGHIKLTDFGLSKESIFEE--NKTYSFCGTVEYMAPEVVNRKGHGTPADWWSYGVLMFEMLTGALPFQGANRKETMTQILKAKLGMPPFLSAEAQSLLRALFKRNPANRLGSAPNGMEEIKKHPFFSTINWVKLFKRELQPPFKPAVVQTDDVFYFDKEFTSKTPKDSPGIPPSATAHELFRGFSFIAPALLESENPTPPPDHVLVNNNNLAKLPGVKTSLFSDDYELKEDIGIGSYSVCKRCIHKASGNSFAVKIMDKDKRDPSEEVEILLRFGRHPNVITLRDVYDNGNKVYLVTELMRGGELLDKILRQKFFSEREASAVLQIVAKTVDYLHSNGVVHRDLKPSNILYADDSGSPDSLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDASCDVWSLGVLLYTMLAGHTPFANGPNDTPNDILARIGEGKFSLVGGNWDSVSPQAKELVKRMLHIDPHSRLTASQVLNHPWISQRDSLPHLRLTLQ-DAQLVKGSVAATFKALNSQNFKQATLEPVGASRLAQRRGKPRPKSSTEL 734

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BLAST of Ribosomal protein S6 kinase vs. TrEMBL
Match: R7TKT4 (Ribosomal protein S6 kinase OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_229226 PE=3 SV=1)

HSP 1 Score: 893.264 bits (2307), Expect = 0.000e+0
Identity = 458/744 (61.56%), Postives = 555/744 (74.60%), Query Frame = 2

Query:  122 MPLGPVTDSFHISNLNEVEVD-----------EEFSDNAFSQEEEATEVNAVDLV---DEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKISGWQNIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKALLEKSLPNLAPVANSTLAKRRGQSKPKSSTEI 2311
            MPL P+ D +      +VEVD           E+ S +  +  E  +E+   D++    E++D+S FELL+VLGQGSFGKVFLVRKV     G LYAMKVLKKA+LKV+DR RTKMERDILA + HPFIV LHYAFQ EGK+YLIL+FL+GGDLF+RLSKE MFTE+DVKFYLAELALALDHLHSLGI+YRDLKPENILLD +GH+KLTDFGLSKESI+ +   +TFSFCGTVEYMAPEVVNRKGHGT ADWWS+GVLMFEMLTG LPFQG +RKETMTMILKAKL MPQFLS EAQ+LLR LFKRNP+NR+G GP GIE+IK   FF  I W  L+ R V PPFKP  + +D+   FD++FTS+TPK+SP  P SA A+E+FRGFSYVAP +++ +               + GVK +     Y L EE+G GS+S C + VHK  G  YA+K+I+  KRD  EEVEIL R+G H +I+ L +VY   + V L+ E L GGELL  IL QK+FSE+EAS +L ++T+T+HYLH+  VVHRDLKPSNILY+ +  NPE+L ICDFGFAKQ RAENGLLMTPCYTANFVAPEVLKKQGYD A DVWSLGVLL+ ML+G+TPF    +D P  IL RI +  FQL+GG WE +SS AKDL+ KMLH DP QRIT  Q+L H W+  R  LP  ++  + + S +KGA+KAT+KA+       LAPV  S+LA+RRG++KPK+STE+
Sbjct:    1 MPLAPLHDPWQ-----KVEVDPSPEGHEDMVIEDGSTDHQNDNETMSEIEVTDMMKKSSERVDASMFELLKVLGQGSFGKVFLVRKVKGDDVGNLYAMKVLKKATLKVRDRVRTKMERDILADVHHPFIVRLHYAFQTEGKLYLILQFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDSEGHVKLTDFGLSKESIFEE--KKTFSFCGTVEYMAPEVVNRKGHGTGADWWSYGVLMFEMLTGALPFQGQNRKETMTMILKAKLGMPQFLSPEAQSLLRALFKRNPANRLGAGPGGIEDIKRHAFFSTITWDKLMKRLVPPPFKPAVSRVDEAFYFDTEFTSRTPKDSPGVPPSAQAHELFRGFSYVAPLLIEGSVPPAKNTAGSVTLSRLPGVKTKPFTEDYDLGEELGVGSYSTCRKCVHKAKGKEYAVKIINREKRDPAEEVEILLRYGEHINIITLCDVYDNGSQVYLVSELLRGGELLDKILRQKFFSEREASAVLQIITKTIHYLHSQGVVHRDLKPSNILYADESGNPESLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKKQGYDAACDVWSLGVLLYTMLAGQTPFANGPNDTPNVILSRIGEGKFQLSGGNWESVSSLAKDLVGKMLHVDPHQRITVQQVLKHPWVANRDQLPQLRLT-HQEASLIKGAMKATFKAINNSPKALLAPVGASSLAQRRGKNKPKNSTEV 736

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BLAST of Ribosomal protein S6 kinase vs. TrEMBL
Match: A0A210QHD3 (Ribosomal protein S6 kinase OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT01224 PE=3 SV=1)

HSP 1 Score: 887.486 bits (2292), Expect = 0.000e+0
Identity = 454/743 (61.10%), Postives = 566/743 (76.18%), Query Frame = 2

Query:  122 MPLGPVTDSFH---------ISNLNEVEVDEEFSDNAFSQEEEATEVNAVDLVDEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLM---FEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQ-HAQNANIEDMKISGWQNIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKALLEKSLPNLAPVANSTLAKRRGQSKPKSSTEI 2311
            MPL  + D +           ++  ++ VDE+ +DN   +E    +V ++    E++ +S FELL+VLGQGSFGKVFLVRKV+    G LYAMKVLKKA+LKV+DR+RTKMERDILA + HPFIV L YAFQ EGK+YLILEFL+GGDLF+RLSKE MFTE+DVKFYLAELALALDHLHSLGIVYRDLKPENILLD DGHIKLTDFGLSKESI+  D  +T+SFCGTVEYMAPEVVNRKGHGTAADWWS+GVLM   FEMLTG LPFQG++RKETMT ILKAKL MPQFLS EAQ+LLR LFKRNP NR+G G  GIE+IK+QPFF  I++  L+ RK  PPFKP     DD   FD++FTS+TPK+SP  P SATA+E+FRGFS+VAP +L  +++  N  D +IS  + + GVK  +    Y +KE+IG GS+SVC R +HK TG ++A+K++D  KRD  EEVEIL RFG HP+I+ L++V+   N V ++ E ++GGELL  IL Q++FSE+EAS +L V+ +TV YLH+N VVHRDLKPSNILY+ +  +P++L ICDFGFAKQ RA+NGLLMTPCYTANFVAPEVLK+QGYD A D+WSLGVLL+ ML+G TPF     D P +IL RI    F L+GG W+ +S  AKDL+ KMLH DP  R+T  Q+L+++WI  R +LP  ++ +  D   VKGA+ AT++AL ++  P L PV  STLA+RRG+++PKSST +
Sbjct:    1 MPLAQLADPWRRMEMAHEAEAASTEDMLVDEQ-NDNEMDRE---IDVTSLMKDGERVSASDFELLKVLGQGSFGKVFLVRKVTGTDAGGLYAMKVLKKATLKVRDRQRTKMERDILADVNHPFIVKLDYAFQTEGKLYLILEFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIVYRDLKPENILLDTDGHIKLTDFGLSKESIF--DEKKTYSFCGTVEYMAPEVVNRKGHGTAADWWSYGVLMLSQFEMLTGALPFQGTNRKETMTQILKAKLGMPQFLSPEAQSLLRALFKRNPQNRLGMGVNGIEDIKTQPFFSTIDFDRLMTRKTNPPFKPAVVQTDDAFYFDTEFTSRTPKDSPGIPPSATAHELFRGFSFVAPALLHDNSEIPNPLDNEIS-LKKLPGVKSVQFSDEYEMKEDIGIGSYSVCKRCIHKLTGGSFAVKIMDKEKRDPSEEVEILLRFGHHPNIISLRDVFDNGNKVYMVTELMQGGELLDKILRQRFFSEREASAVLQVVAKTVEYLHSNGVVHRDLKPSNILYADESGSPDSLRICDFGFAKQLRADNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLAGHTPFANGPKDTPNDILSRIGTGKFTLSGGNWDSVSPAAKDLVQKMLHVDPQSRLTATQVLNNSWIAHRETLPHLRLTLQ-DAQLVKGAMHATFEALKDQPKPVLEPVGASTLAQRRGKNRPKSSTAV 735

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BLAST of Ribosomal protein S6 kinase vs. TrEMBL
Match: V4B8C1 (Ribosomal protein S6 kinase OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_236015 PE=3 SV=1)

HSP 1 Score: 884.789 bits (2285), Expect = 0.000e+0
Identity = 453/734 (61.72%), Postives = 556/734 (75.75%), Query Frame = 2

Query:  122 MPLGPVTDSF-HISNLNEVEVDEEFSDNAFSQEEEATEVNAVDLVDEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQN-ANIEDMKISGWQNIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKAL--LEKSLPNLAPVANSTLAKRRGQSKPKSSTEI 2311
            MPL P+ D +  +   NEVEV            E   EV+  +    K   S FELL+VLGQGSFGKVFLVRK++    G LYAMKVLKKA+LKVQDRKRTKMERDILA + HPFIV LHYAFQ EGK+YLILEFL+GGDLF+RLSKE MFTE+DVKFYLAELALALDHLHSLGI+YRDLKPENILLD +GHIKLTDFGLSKESI+ +   +T+SFCGTVEYMAPEVVNRKGH TAADWWS+G+LMFEMLTG LPFQG++RKETMT ILKAKL MP FL+ EAQ+LLR LFKRNP+NR+G GP GIE+IK+ PFF  I+W  L  R ++PPFKP     D+   FD++FT +TPK+SP  PASATA+E+F+GFS++AP +L   +   +  D +IS    + GVK    +  Y LKE+IG GS+SVC R VHK++G++YA+K++D  KRD  EE+EIL RFG H +I+ L++V+   N V ++ E ++GGELL  IL QK+FSE+EAS +L V+ +TV YLH+N VVHRDLKPSNILY+    +PE+L ICDFGFAKQ RAENGLLMTPCYTANFVAPEVLK+QGYD A D+WSLGVLL+ ML+G TPF    +D P +IL RI +  F L+GG W+ +S  AKDL+ +MLH DP+ RIT  Q+L+H WI  R SLP  ++++  D   VKGA+ AT+ AL    K  P L PV  S+LA+RRG++KPKSST +
Sbjct:    1 MPLAPLADPWKRMETSNEVEV--------ILNNESDIEVDITNCCKFKAQPSDFELLKVLGQGSFGKVFLVRKINGDDNGTLYAMKVLKKATLKVQDRKRTKMERDILADVSHPFIVELHYAFQTEGKLYLILEFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDAEGHIKLTDFGLSKESIFEE--KKTYSFCGTVEYMAPEVVNRKGHFTAADWWSYGILMFEMLTGALPFQGNNRKETMTQILKAKLGMPPFLTPEAQSLLRALFKRNPANRLGSGPNGIEDIKNHPFFASIDWVKLKKRSLSPPFKPAVVLSDEVFYFDTEFTMRTPKDSPGIPASATAHELFKGFSFIAPALLGETEKPVDPLDNQIS-LAKLPGVKTIPFNDEYDLKEDIGIGSYSVCKRCVHKSSGISYAVKIMDKDKRDPSEEIEILLRFGHHSNIITLRDVFDNGNKVYMVTELMKGGELLDKILRQKFFSEREASAVLQVVAKTVEYLHSNGVVHRDLKPSNILYADDSGSPESLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAAVDLWSLGVLLYTMLAGHTPFANGPNDTPNDILARIGQGKFSLSGGNWDSVSQPAKDLVQRMLHLDPSNRITATQVLNHPWIAQRDSLPHLRLSLQ-DAHLVKGAMAATFNALNGNTKLRPVLDPVGASSLAQRRGKNKPKSSTAV 722

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BLAST of Ribosomal protein S6 kinase vs. TrEMBL
Match: A0A1S3H586 (Ribosomal protein S6 kinase OS=Lingula unguis OX=7574 GN=LOC106152318 PE=3 SV=1)

HSP 1 Score: 882.093 bits (2278), Expect = 0.000e+0
Identity = 446/742 (60.11%), Postives = 552/742 (74.39%), Query Frame = 2

Query:  122 MPLGPVTDSFH---ISNLNEVEVDEEF--SDNAFSQEEEATEVNAVDLV--DEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHA----QNANIEDMKISGWQNIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKALLEKSLPNLAPVANSTLAKRRGQSKPK-SSTEI 2311
            MPL  + D +    + +L +    E+    D    +E +  E+    LV   EK +   FELL+VLGQGSFGKVFLVRK+S    G LYAMKVLKKA+LKV+DR RTKMERDILA + HPFIV LHYAFQ EGK+YLILEFL+GGDLF+RLSKE MFTE+DVKFYLAELAL+L+HLH +GI+YRDLKPEN+LLD DGH+KLTDFGLSKESI+ +   +T+SFCGTVEYMAPEVVNR+GHGTAADWWS+GVLMFEMLTGQLPFQG +RK+TMT ILKAKL MPQFLS EAQ+LLR LFKRNP+NR+G G  GIE+IK  PFF  I+W+ L+ R++ PPFKP  T  DD   FD++FTSKTPK+SP  P SATA+E+FRGFSY+AP +++      QN   E  K +    + GV  +     Y LKEEIG GS+S+C R VHK +G +YA+K+ID  KRD  EEVEIL R+G+HP+IV L++VY   N V L+ E ++GGELL  I  QK+FSE+EAS +L V+  TV +LH + VVHRDLKPSNILY+    +PE + ICDFGFAKQ RA+NGLLMTPCYTANFVAPEVLKKQGYD+A D+WS+GVLL+ ML+G TPF    +D P +IL RI +    LTGG W+ +S  AKDL+  MLH +P QR T  Q+L+H W+  R +LP  K+  + D+  VKGA+K  Y+AL       L PV  S+LA+RRG++KP+ +STE+
Sbjct:    1 MPLAQLADPWQRVEVQSLRQTPSTEDMLVDDQENDEEMQDQEIEVTTLVRKGEKCNPGDFELLKVLGQGSFGKVFLVRKISGHDAGTLYAMKVLKKATLKVRDRVRTKMERDILADVDHPFIVKLHYAFQTEGKLYLILEFLRGGDLFTRLSKEVMFTEEDVKFYLAELALSLNHLHQVGIIYRDLKPENVLLDADGHVKLTDFGLSKESIFEE--KKTYSFCGTVEYMAPEVVNRRGHGTAADWWSYGVLMFEMLTGQLPFQGQNRKDTMTQILKAKLGMPQFLSPEAQSLLRALFKRNPANRLGSGDDGIEDIKKHPFFSTISWEKLVKREINPPFKPAVTKADDAYYFDTEFTSKTPKDSPGVPPSATAHELFRGFSYIAPRLIEETVMEEQNPKPEPAKTTRKTILRGVNTKSFSEEYELKEEIGVGSYSLCKRCVHKLSGQSYAVKIIDKEKRDPSEEVEILLRYGSHPNIVTLRDVYDNGNKVYLVTELMKGGELLDKIYRQKFFSEREASAVLQVVARTVDHLHKSGVVHRDLKPSNILYADDSGDPEQIRICDFGFAKQLRADNGLLMTPCYTANFVAPEVLKKQGYDEACDIWSMGVLLYTMLAGYTPFATGPNDTPNDILARIGEGKISLTGGNWDSVSVAAKDLVKHMLHLNPRQRFTAEQVLNHPWVAKRENLPQLKLT-HQDVQLVKGAMKTMYRALNNSPKLMLEPVGASSLAQRRGKNKPRLNSTEV 739

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BLAST of Ribosomal protein S6 kinase vs. Ensembl Cavefish
Match: rps6ka2 (ribosomal protein S6 kinase A2 [Source:NCBI gene;Acc:103036630])

HSP 1 Score: 830.476 bits (2144), Expect = 0.000e+0
Identity = 424/686 (61.81%), Postives = 512/686 (74.64%), Query Frame = 2

Query:  257 EKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKISGWQNIVGVKFQKVDHY---YTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKAL-LEKSLPNLAPVANSTLAKRRGQSKPKSS 2302
            EK D S FELL+VLGQGS+GKVFLVRK+     G LYAMKVLKKA+LKV+DR R+KMERDILA + HPFIV LHYAFQ EGK+YLIL+FL+GGDLF+RLSKE MFTE+DVKFYLAELALALDHLHSLGI+YRDLKPENILLDEDGHIK+TDFGLSKE+I +D   R +SFCGT+EYMAPEVVNR+GH  +ADWWSFGVLMFEMLTG LPFQG  RKETM +ILKAKL MPQFLSSE Q+LLR LFKRNPSNR+G GP G+EEIK   FF  I+W  L  +++ PPFKP     +DT  FD +FTS+TP +SP  P SA A+++FRGFS+VA ++       +I D + +    IV        H+   Y +KE+IG GS+SVC R +H+ T V YA+K+I+ +K+D  EE+EIL R+G HP+I+ LK+VY     V L+ME + GGELL  IL QK FSE+EAS +L  +T+TV YLH+  VVHRDLKPSNILY  +  +PE++ ICDFGFAKQ RAENGLLMTPCYTANFVAPEVLKKQGYD A D+WSLG+LL+ ML+G TPF     D PEEIL RI    + L+GG W+ +S  AKD++ KMLH DP QR+T   +L H WI  R  L  + + +  D+  VKGA+ ATY AL      P L PV  S LA+RRG  +  S+
Sbjct:   52 EKADPSQFELLKVLGQGSYGKVFLVRKIKGSDTGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEDGHIKITDFGLSKEAIDHD--KRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSSEVQSLLRALFKRNPSNRLGAGPDGVEEIKRHHFFATIDWNKLYRKEIKPPFKPAVGRPEDTFHFDPEFTSRTPTDSPGVPPSANAHQLFRGFSFVATNL---RPEQSITDTRQNSVNPIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCIHRITSVEYAVKIIEKSKKDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQKGFSEREASAVLCTITKTVEYLHSQGVVHRDLKPSNILYVDETGDPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKKQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYILSGGNWDTVSDAAKDIVTKMLHVDPHQRLTAPLVLRHPWIVNRDELSQSHL-VRQDVQLVKGAMAATYSALNRTPQAPKLEPVLASGLAQRRGMKRLTST 731

[Close]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Cavefish
Match: rps6ka1 (ribosomal protein S6 kinase a, polypeptide 1 [Source:ZFIN;Acc:ZDB-GENE-060929-516])

HSP 1 Score: 805.438 bits (2079), Expect = 0.000e+0
Identity = 415/695 (59.71%), Postives = 506/695 (72.81%), Query Frame = 2

Query:  230 EVNAVDLVDE---KLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKISGWQNIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKAL-LEKSLPNLAPVANSTLAKRRGQSKPKSS 2302
            E+N   +V E   K D S FELL+VLGQGSFGKVFLVRK++ P    LYAMKVL+KA+LKV+DR RTKMER+ILA + HPF+V LHYAFQ EGK+YLIL+FL+GGDLF+RLSKE MFTE+DVKFYLAELAL LDHLHSLGI+YRDLKPENILLDE+GHIKLTDFGL KE+I  D   + +SFCGTVEYMAPEVVNR+GH  +ADWWSFGVLMFEMLTG LPFQG  RKETM +ILKA+L MPQFLS+EAQ+LLR LFKRNP+NR+G G  G EEIK   FF  I+W  L  R++ PPF+P     DDT  FDS+FTS+TPK+SP  P SA A+++FRGFS+VA  +L    +   E+        +V V  Q V      +++    S          +T   YA+KVID T  D  EE+EIL R+G HP+I+ LK+VY     V ++ E + GGELL  IL QK+FSE+EAS +L+ +T+TV YLH+  VVHRDLKPSNILY  +  NPE+L ICDFGFAKQ RA+NGLLMTPCYTANFVAPEVLK+QGYD+  D+WSLGVLL+ ML+G TPF     D PEEIL RI    F +TGG W+ +S  AK+L+ KMLH DP QR+T  Q+L H WI  R  LP++++  + D   VKGA+ ATY AL   +  P L P+ +S LA+RR +  P +S
Sbjct:   19 EINITHVVKEGAEKADPSQFELLKVLGQGSFGKVFLVRKITPPDSNQLYAMKVLRKATLKVRDRVRTKMERNILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLCKEAI--DLEKKAYSFCGTVEYMAPEVVNRQGHIHSADWWSFGVLMFEMLTGSLPFQGKDRKETMNLILKARLGMPQFLSAEAQSLLRALFKRNPTNRLGSGADGAEEIKRHAFFFTIDWNKLFRREIKPPFRPAVARPDDTFYFDSEFTSRTPKDSPGVPPSADAHKLFRGFSFVATAMLD---DVGGEETVQQPPHPVVQVSGQLVGSRCLFEDKQALYSIEHAVTDCGHSTNTEYAVKVIDKTSTDPSEEIEILLRYGQHPNIITLKDVYDNGKQVYVVTELMRGGELLDRILKQKFFSEREASAVLHTITKTVEYLHSQGVVHRDLKPSNILYVDESGNPESLRICDFGFAKQLRADNGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGVLLYTMLAGFTPFANGPEDTPEEILSRIGSGHFTVTGGNWDAVSDSAKELVSKMLHVDPHQRLTAKQVLKHPWIVHRDQLPNSQL-QHQDAQLVKGAMAATYSALKSSQPPPELKPIESSFLAQRRVKKLPSTS 707

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BLAST of Ribosomal protein S6 kinase vs. Ensembl Cavefish
Match: rps6ka1 (ribosomal protein S6 kinase a, polypeptide 1 [Source:ZFIN;Acc:ZDB-GENE-060929-516])

HSP 1 Score: 804.668 bits (2077), Expect = 0.000e+0
Identity = 415/695 (59.71%), Postives = 506/695 (72.81%), Query Frame = 2

Query:  230 EVNAVDLVDE---KLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKISGWQNIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKAL-LEKSLPNLAPVANSTLAKRRGQSKPKSS 2302
            E+N   +V E   K D S FELL+VLGQGSFGKVFLVRK++ P    LYAMKVL+KA+LKV+DR RTKMER+ILA + HPF+V LHYAFQ EGK+YLIL+FL+GGDLF+RLSKE MFTE+DVKFYLAELAL LDHLHSLGI+YRDLKPENILLDE+GHIKLTDFGL KE+I  D   + +SFCGTVEYMAPEVVNR+GH  +ADWWSFGVLMFEMLTG LPFQG  RKETM +ILKA+L MPQFLS+EAQ+LLR LFKRNP+NR+G G  G EEIK   FF  I+W  L  R++ PPF+P     DDT  FDS+FTS+TPK+SP  P SA A+++FRGFS+VA  +L    +   E+        +V V  Q V      +++    S          +T   YA+KVID T  D  EE+EIL R+G HP+I+ LK+VY     V ++ E + GGELL  IL QK+FSE+EAS +L+ +T+TV YLH+  VVHRDLKPSNILY  +  NPE+L ICDFGFAKQ RA+NGLLMTPCYTANFVAPEVLK+QGYD+  D+WSLGVLL+ ML+G TPF     D PEEIL RI    F +TGG W+ +S  AK+L+ KMLH DP QR+T  Q+L H WI  R  LP++++  + D   VKGA+ ATY AL   +  P L P+ +S LA+RR +  P +S
Sbjct:   53 EINITHVVKEGAEKADPSQFELLKVLGQGSFGKVFLVRKITPPDSNQLYAMKVLRKATLKVRDRVRTKMERNILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLCKEAI--DLEKKAYSFCGTVEYMAPEVVNRQGHIHSADWWSFGVLMFEMLTGSLPFQGKDRKETMNLILKARLGMPQFLSAEAQSLLRALFKRNPTNRLGSGADGAEEIKRHAFFFTIDWNKLFRREIKPPFRPAVARPDDTFYFDSEFTSRTPKDSPGVPPSADAHKLFRGFSFVATAMLD---DVGGEETVQQPPHPVVQVSGQLVGSRCLFEDKQALYSIEHAVTDCGHSTNTEYAVKVIDKTSTDPSEEIEILLRYGQHPNIITLKDVYDNGKQVYVVTELMRGGELLDRILKQKFFSEREASAVLHTITKTVEYLHSQGVVHRDLKPSNILYVDESGNPESLRICDFGFAKQLRADNGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGVLLYTMLAGFTPFANGPEDTPEEILSRIGSGHFTVTGGNWDAVSDSAKELVSKMLHVDPHQRLTAKQVLKHPWIVHRDQLPNSQL-QHQDAQLVKGAMAATYSALKSSQPPPELKPIESSFLAQRRVKKLPSTS 741

[Close]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Cavefish
Match: rps6ka1 (ribosomal protein S6 kinase a, polypeptide 1 [Source:ZFIN;Acc:ZDB-GENE-060929-516])

HSP 1 Score: 794.653 bits (2051), Expect = 0.000e+0
Identity = 413/695 (59.42%), Postives = 503/695 (72.37%), Query Frame = 2

Query:  230 EVNAVDLVDE---KLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKISGWQNIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKAL-LEKSLPNLAPVANSTLAKRRGQSKPKSS 2302
            E+N   +V E   K D S FELL+VLGQGSFGKVFLVRK++ P    LYAMKVL+KA+LKV+DR RTKMER+ILA + HPF+V LHYAFQ EGK+YLIL+FL+GGDLF+RLSKE MFTE+DVKFYLAELAL LDHLHSLGI+YRDLKPENILLDE+GHIKLTDFGL KE+I  D   + +SFCGTVEYMAPEVVNR+GH  +ADWWSFGVLMFEMLTG LPFQG  RKETM +ILKA+L MPQFLS+EAQ+LLR LFKRNP+NR+G G  G EEIK   FF  I+W  L  R++ PPF+P     DDT  FDS+FTS+TPK+SP  P SA A+++FRGFS+VA  +L    +   E+        +V V  Q V      +++         Y   H  T   +   VID T  D  EE+EIL R+G HP+I+ LK+VY     V ++ E + GGELL  IL QK+FSE+EAS +L+ +T+TV YLH+  VVHRDLKPSNILY  +  NPE+L ICDFGFAKQ RA+NGLLMTPCYTANFVAPEVLK+QGYD+  D+WSLGVLL+ ML+G TPF     D PEEIL RI    F +TGG W+ +S  AK+L+ KMLH DP QR+T  Q+L H WI  R  LP++++  + D   VKGA+ ATY AL   +  P L P+ +S LA+RR +  P +S
Sbjct:   23 EINITHVVKEGAEKADPSQFELLKVLGQGSFGKVFLVRKITPPDSNQLYAMKVLRKATLKVRDRVRTKMERNILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLCKEAI--DLEKKAYSFCGTVEYMAPEVVNRQGHIHSADWWSFGVLMFEMLTGSLPFQGKDRKETMNLILKARLGMPQFLSAEAQSLLRALFKRNPTNRLGSGADGAEEIKRHAFFFTIDWNKLFRREIKPPFRPAVARPDDTFYFDSEFTSRTPKDSPGVPPSADAHKLFRGFSFVATAMLD---DVGGEETVQQPPHPVVQVSGQLVGSRCLFEDK------QALYSIEHAVTDCGHC--VIDKTSTDPSEEIEILLRYGQHPNIITLKDVYDNGKQVYVVTELMRGGELLDRILKQKFFSEREASAVLHTITKTVEYLHSQGVVHRDLKPSNILYVDESGNPESLRICDFGFAKQLRADNGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGVLLYTMLAGFTPFANGPEDTPEEILSRIGSGHFTVTGGNWDAVSDSAKELVSKMLHVDPHQRLTAKQVLKHPWIVHRDQLPNSQL-QHQDAQLVKGAMAATYSALKSSQPPPELKPIESSFLAQRRVKKLPSTS 703

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BLAST of Ribosomal protein S6 kinase vs. Ensembl Cavefish
Match: rps6kal (ribosomal protein S6 kinase a, like [Source:NCBI gene;Acc:337670])

HSP 1 Score: 788.104 bits (2034), Expect = 0.000e+0
Identity = 411/684 (60.09%), Postives = 500/684 (73.10%), Query Frame = 2

Query:  257 EKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKISGWQNIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVK-GAVKATYKALLEKSL-PNLAPVANSTLAKRRGQSKPKSS 2302
            EK D S FELL+VLGQGSFGKVFLVRK+  P  G LYAMKVLKKASLKV+DR RTKMERDIL  + HPFIV LHYAFQ EGK+YLIL+FL+GGD+F+RLSKE MFTE+DVKFYLAELALALDHLH+LGIVYRDLKPENILLDE GHIKLTDFGLSKES+  D   + +SFCGTVEYMAPEVVNR+GH  +ADWWS GVLMFEMLTG LPFQG  R ETM MILKAKL MPQFLS EAQ+LLR+LFKRNP+NR+G GP G+EEIK   FF  I+W  L  +++ PPFKP A   DDT CFD +FT+KTPK+SP  P SA A+++F+GFS+VAP  L+ ++++    + I    +    +F  V   Y LKE+IG GS+S+C R +H+ T + +A+K+ID +KRD  EE+EIL R+G HP+I+ LK+VY +   V L+ E ++GGELL  IL QK+FSE+EAS +LY +T+TV YLH   VVHRDLKPSNILY     NP+++ ICDFGFAKQ R +NGLL+TPCYTANFVAPEVL +QGYD A D+WSLGVLL+ ML+G TPF    +D PEEIL RI    F L+GG W+ +S  +K                    + H + +   SL  +     S   S + GA+ ATY AL  K+  P L PVA S+LA+RR   K  S+
Sbjct:   53 EKADPSQFELLKVLGQGSFGKVFLVRKIMGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVMFTEEDVKFYLAELALALDHLHNLGIVYRDLKPENILLDEAGHIKLTDFGLSKESV--DQDRKAYSFCGTVEYMAPEVVNRRGHTQSADWWSLGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSLEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHAFFSTIDWNKLYRQELQPPFKPAAGKPDDTFCFDPEFTAKTPKDSPGIPPSANAHQLFKGFSFVAPASLEESKSSPFNILPIVQMHS-GAAQFSDV---YELKEDIGVGSYSICKRCIHRVTAMEFAVKIIDKSKRDPSEEIEILMRYGQHPNIITLKDVYDEGRFVYLVTELMKGGELLDKILRQKFFSEREASAVLYTITKTVDYLHCQGVVHRDLKPSNILYMDDSGNPDSIRICDFGFAKQLRGDNGLLLTPCYTANFVAPEVLMRQGYDAACDIWSLGVLLYTMLAGYTPFANGPNDTPEEILLRIGSGKFSLSGGNWDTVSDSSK--------------------VEHTFFSLSLSLSLSLSFFLSFFLSNEYGAMAATYSALNHKTCQPVLEPVAASSLAQRRSMKKLTST 710

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BLAST of Ribosomal protein S6 kinase vs. Ensembl Sea Lamprey
Match: RPS6KA3 (ribosomal protein S6 kinase A3 [Source:HGNC Symbol;Acc:HGNC:10432])

HSP 1 Score: 337.806 bits (865), Expect = 9.072e-111
Identity = 159/260 (61.15%), Postives = 192/260 (73.85%), Query Frame = 2

Query: 1352 YTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVI-DGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWIT 2128
            Y L+E+IG GS+SVC R +HKTT + YA+KVI D +KRD  EE+EIL R+G HP+++ LK+VY    +V L+ E ++GGELL  IL QK+FSE+EAS +L  +  TV YLH+  VVHRDLKPSNILY  +  NPE+L ICDFGFAKQ RAENGLLMTPCYTANFVAPEVLK+QGYD A D+WSLGVLL+ ML+G TPF     D P  IL RI    F L+GG W+ +S  AKDL+ KMLH DP QR T  Q+L H WI 
Sbjct:   12 YELREDIGVGSYSVCKRCIHKTTNMEYAVKVIIDKSKRDPSEEIEILLRYGQHPNVITLKDVYDDGKSVYLVTELMKGGELLDKILRQKFFSEREASAVLQTIARTVEYLHSQGVVHRDLKPSNILYVDESGNPESLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLAGHTPFANGPDDTPGVILTRIGSGRFLLSGGNWDTVSEAAKDLVKKMLHVDPHQRFTAAQVLRHPWIA 271

HSP 2 Score: 107.457 bits (267), Expect = 3.498e-26
Identity = 79/261 (30.27%), Postives = 138/261 (52.87%), Query Frame = 2

Query:  269 SSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENIL-LDEDGH---IKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFL---------SSEAQTLLRVLFKRNPSNR 1012
            S  +EL   +G GS+    + ++       + YA+KV+   S     R  ++    +L   +HP ++TL   + +   VYL+ E +KGG+L  ++ ++  F+E +    L  +A  +++LHS G+V+RDLKP NIL +DE G+   +++ DFG +K+     +     + C T  ++APEV+ R+G+  A D WS GVL++ ML G  PF  +   +T  +IL  ++   +FL         S  A+ L++ +   +P  R
Sbjct:    9 SDGYELREDIGVGSYS---VCKRCIHKTTNMEYAVKVIIDKS----KRDPSEEIEILLRYGQHPNVITLKDVYDDGKSVYLVTELMKGGELLDKILRQKFFSEREASAVLQTIARTVEYLHSQGVVHRDLKPSNILYVDESGNPESLRICDFGFAKQ--LRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLAGHTPF-ANGPDDTPGVIL-TRIGSGRFLLSGGNWDTVSEAAKDLVKKMLHVDPHQR 258

[Close]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004683.1 (pep scaffold:Pmarinus_7.0:GL488517:199:5283:1 gene:ENSPMAG00000004265.1 transcript:ENSPMAT00000004683.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 281.952 bits (720), Expect = 8.407e-91
Identity = 149/179 (83.24%), Postives = 161/179 (89.94%), Query Frame = 2

Query:  482 AFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIG 1018
            AFQ EGK+YLIL+FL+GGDLF+RLSKE MFTE+DVKFYLAELALALDHLHSLGI+YRDLKPENILLDE GHI LTDFGLSKESI  D   + +SFCGTVEYMAPEVVNRKGH  +ADWWSFGVLMFEMLTG LPFQG  RKETMTMILKAKL MPQFLS EAQ+LLR+LFKRNP NR+G
Sbjct:    1 AFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDESGHIGLTDFGLSKESI--DHEKKAYSFCGTVEYMAPEVVNRKGHTHSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSGEAQSLLRMLFKRNPGNRLG 177

HSP 2 Score: 96.2857 bits (238), Expect = 3.399e-23
Identity = 55/187 (29.41%), Postives = 99/187 (52.94%), Query Frame = 2

Query: 1532 VYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRI 2092
             +  +  + LI+++L GG+L T +  +  F+E++    L  L   + +LH+  +++RDLKP NIL  +      ++ + DFG +K+         + C T  ++APEV+ ++G+  ++D WS GVL+F ML+G  PF   +    +E +  I K       G  + +S EA+ LL  +   +P  R+
Sbjct:    1 AFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDESG----HIGLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRKGHTHSADWWSFGVLMFEMLTGTLPFQGKDR---KETMTMILKAKL----GMPQFLSGEAQSLLRMLFKRNPGNRL 176

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BLAST of Ribosomal protein S6 kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008480.1 (pep scaffold:Pmarinus_7.0:GL482122:191709:206473:1 gene:ENSPMAG00000007654.1 transcript:ENSPMAT00000008480.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 258.455 bits (659), Expect = 9.402e-78
Identity = 135/343 (39.36%), Postives = 204/343 (59.48%), Query Frame = 2

Query:  182 DEEFSDNAFSQEEEATEVNAVDLV----DEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDR-KRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFY-XXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESP 1192
            ++E  D   S  E+ +    +D +      K+  ++F+ L++LG+G+FGKV LVR   E   G  YAMK+LKK  +  +D    T  E  +L   +HPF+  L Y+FQ   ++  ++E++ GG+LF  LS+E +F+ED  +FY    ++          +VYRDLK EN++LD+DGHIK+ DFGL KE I +    +TF  CGT EY+APEV+    +G A DWW  GV+M+EM+ G+LPF     ++   +IL   +  P+ LS++A+ LL  L K++P  R+G G    +EI    FF  I W+D+ +RK+TPPFKP+     DT  FD +FT++T   +P
Sbjct:  114 EDETMDCKPSSPEDGSSTEQMDTILSKPKSKVTMNNFDYLKLLGKGTFGKVILVR---EKATGQYYAMKILKKEVIVAKDEVAHTLTENRVLQTTKHPFLTLLKYSFQTHDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHTEKNVVYRDLKLENLMLDKDGHIKIADFGLCKEGITDGATMKTF--CGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIRFPRTLSNDARALLSGLLKKDPKQRLGGGVDDAKEIMRHSFFAGIIWQDVYDRKMTPPFKPQVASETDTRYFDEEFTAQTITITP 451

HSP 2 Score: 119.013 bits (297), Expect = 1.674e-28
Identity = 81/267 (30.34%), Postives = 135/267 (50.56%), Query Frame = 2

Query: 1370 IGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVI---EEV------EILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNL-VVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRI-----TTNQILSHNWI 2125
            +GKG+F        K TG  YA+K++   K++VI   +EV        + +   HP +  LK  +   + +  +MEY+ GGEL  ++  ++ FSE         +   + YLHT   VV+RDLK  N++  K      ++ I DFG  K+   +   + T C T  ++APEVL+   Y +A D W LGV+++ M+ G+ PF   +H+   E++  +E   F  T      +S++A+ LL  +L  DP QR+        +I+ H++ 
Sbjct:  156 LGKGTFGKVILVREKATGQYYAMKIL---KKEVIVAKDEVAHTLTENRVLQTTKHPFLTLLKYSFQTHDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHTEKNVVYRDLKLENLMLDKDG----HIKIADFGLCKEGITDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI-LMEDIRFPRT------LSNDARALLSGLLKKDPKQRLGGGVDDAKEIMRHSFF 408

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BLAST of Ribosomal protein S6 kinase vs. Ensembl Sea Lamprey
Match: rps6ka5 (ribosomal protein S6 kinase, polypeptide 5 [Source:ZFIN;Acc:ZDB-GENE-130530-693])

HSP 1 Score: 244.202 bits (622), Expect = 1.221e-72
Identity = 157/439 (35.76%), Postives = 235/439 (53.53%), Query Frame = 2

Query: 1058 FFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKI-SGWQNIVGVKFQK---------VDHY-YTLKEE-IGKGSFSVCYRAVHKTTGVNYAIKVIDGTKR---DVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPP------EEILKRIEKKSFQLTGGQWEHISSEAKDLLL-KMLHCDPAQRITTNQILSHNWITFRSSLPS----TKIAMNSDLSSVKGAVKATYKAL--LEKSLPNLAPVANSTLAKRRGQSK 2290
            F +   W DL  +KV  PFKP      D S F  +FT   P  SP       ++ IF+G+S+VAP +L        + +++ SG +        +           HY   +KE  +G+GSFS+C R  HK TG  +A+K++  +KR   +   E+  L    AHP+IV + +VY       L+ME L+GGELL  I  + +FSE EAS+I+  L     ++H   VVHRDLKP N+L++  DT    + + DFGFA+ +  +N  L TPC+T  + APE+L+  GYD++ DVWSLGV+L+ MLSG+ PF    H  P       +I+++I++  F   G  W+++S  AKDL+  ++L  DP++R+  + +  + W+   S L S    T   + S  SSV    KAT+ A    ++    L  V N+ LAKRR   K
Sbjct:    2 FAKHKTWDDLAAKKVEAPFKPVIRDELDVSNFAEEFTDMDPTYSPAA-LPHNSDRIFKGYSFVAPSILFKRNAVTSDPLELQSGSERPATTAVARSAMMKDSPFFQHYEMDMKEPPLGEGSFSICRRCKHKKTGQEHAVKIV--SKRMEANTQREIAALKLCHAHPNIVNIIDVYHDTLHTYLVMELLKGGELLERIKKRSHFSETEASRIMRKLVSATSFMHDTGVVHRDLKPENLLFAD-DTEGAAIKVIDFGFARLKPQDNAPLKTPCFTLQYAAPELLQHAGYDESCDVWSLGVILYTMLSGQVPF--QSHGQPMTCSSATDIMRKIKEGDFSFEGEAWQNVSQAAKDLIQGRLLTVDPSKRVKMSGLRYNEWLQDGSQLSSNPLLTPDVLVSSGSSVNTYFKATFHAFNQCKREGFCLQKVDNAPLAKRRKMKK 434

HSP 2 Score: 116.701 bits (291), Expect = 7.612e-28
Identity = 83/259 (32.05%), Postives = 136/259 (52.51%), Query Frame = 2

Query:  296 LGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIR----HPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDED---GHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQG-------SSRKETMTMILKAKLSMP----QFLSSEAQTLLR-VLFKRNPSNRI 1015
            LG+GSF    + R+    + G  +A+K++ K       R     +R+I AA++    HP IV +   + +    YL++E LKGG+L  R+ K   F+E +    + +L  A   +H  G+V+RDLKPEN+L  +D     IK+ DFG ++    ++   +T   C T++Y APE++   G+  + D WS GV+++ ML+GQ+PFQ        SS  + M  I +   S      Q +S  A+ L++  L   +PS R+
Sbjct:  117 LGEGSFS---ICRRCKHKKTGQEHAVKIVSK-------RMEANTQREI-AALKLCHAHPNIVNIIDVYHDTLHTYLVMELLKGGELLERIKKRSHFSETEASRIMRKLVSATSFMHDTGVVHRDLKPENLLFADDTEGAAIKVIDFGFARLKPQDNAPLKTP--CFTLQYAAPELLQHAGYDESCDVWSLGVILYTMLSGQVPFQSHGQPMTCSSATDIMRKIKEGDFSFEGEAWQNVSQAAKDLIQGRLLTVDPSKRV 362

[Close]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006766.1 (pep scaffold:Pmarinus_7.0:GL478342:9725:27922:-1 gene:ENSPMAG00000006086.1 transcript:ENSPMAT00000006766.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 239.965 bits (611), Expect = 1.588e-71
Identity = 142/368 (38.59%), Postives = 211/368 (57.34%), Query Frame = 2

Query:  173 VEVDEEFSDNAFSQEEEATEVNAVDLVDEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKAS-LKVQDRKRTKMERDILAA-IRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASAT--------ANEIFRGFSYV 1246
            +++D   +      E +A  +N     + +   S F+ L VLG+GSFGKV L +  S+   GI YA+KV+KK+  L+ ++ K    ER++L   +RHPF+V LHY+FQ+  K+Y +++++ GG+LF  L ++  F E   +FY AE+  A+ +LHSL IVYRDLKPENILLD  GHI LTDFGL KE I  D  + T +FCGT EY+APEV+ +  +    DWW  G +++EML G  PF   + K+    IL   L +    ++ A ++L  L  ++P  R+G     I EIK+  FF  INW DL  +++  P+ P  +   D   FD  FT++    S  Q +  +        A + F GF+Y+
Sbjct:   57 LQLDNPRNQTQGPMENDADHINLGPSANLQAKPSDFDFLTVLGKGSFGKVLLAKHKSD---GIFYAVKVMKKSIILQKKEEKHIMAERNVLVKNVRHPFLVGLHYSFQSADKLYFVMDYVNGGELFFHLQRQGSFPESRAQFYAAEIGSAIGYLHSLNIVYRDLKPENILLDYQGHIVLTDFGLCKEGI--DPHSTTCTFCGTPEYLAPEVLKKHPYDRTVDWWCLGCVLYEMLYGLPPFYSKNLKQMYESILHQPLQLRPCTTNAAISVLEGLLHKDPHQRLG-ATSDILEIKNHVFFSTINWNDLDAKRIPSPYNPGVSGPCDLHNFDPAFTAEPLSMSMAQSSDTSSVCANVDEAADAFVGFTYM 418

HSP 2 Score: 127.102 bits (318), Expect = 1.531e-31
Identity = 82/255 (32.16%), Postives = 130/255 (50.98%), Query Frame = 2

Query: 1370 IGKGSFSVCYRAVHKTTGVNYAIKVIDGT-------KRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRI-TTNQIL 2110
            +GKGSF     A HK+ G+ YA+KV+  +       ++ ++ E  +L +   HP +V L   +   + +  +M+Y+ GGEL  ++  Q  F E  A      +   + YLH+  +V+RDLKP NIL   +     ++V+ DFG  K+    +    T C T  ++APEVLKK  YD+  D W LG +L+ ML G  PF        +++ + I  +  QL        ++ A  +L  +LH DP QR+  T+ IL
Sbjct:   98 LGKGSFGKVLLAKHKSDGIFYAVKVMKKSIILQKKEEKHIMAERNVLVKNVRHPFLVGLHYSFQSADKLYFVMDYVNGGELFFHLQRQGSFPESRAQFYAAEIGSAIGYLHSLNIVYRDLKPENILLDYQG----HIVLTDFGLCKEGIDPHSTTCTFCGTPEYLAPEVLKKHPYDRTVDWWCLGCVLYEMLYGLPPFYSKNL---KQMYESILHQPLQLR----PCTTNAAISVLEGLLHKDPHQRLGATSDIL 341

[Close]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Yeast
Match: TPK3 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication [Source:SGD;Acc:S000001649])

HSP 1 Score: 237.654 bits (605), Expect = 3.772e-71
Identity = 134/301 (44.52%), Postives = 193/301 (64.12%), Query Frame = 2

Query:  260 KLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASL-KVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPK-ATCLDDTSCFD 1156
            K   S F++LR LG GSFG+V L+R       G  YA+K LKK ++ K++  + T  ER +L+ + HPFI+ +   FQ+  +V++++++++GG+LFS L K   F     KFY AE+ LAL++LHS  I+YRDLKPENILLD++GHIK+TDFG +K   Y  D   T++ CGT +Y+APEVV+ K +  + DWWSFGVL++EML G  PF  S+  +T   IL A+L  P F   +AQ LL+ L  R+ S R+G    G E++K+ P+F  + W+ LL R +  P++P       DTS FD
Sbjct:   82 KYSLSDFQILRTLGTGSFGRVHLIRSN---HNGRFYALKTLKKHTIVKLKQVEHTNDERRMLSIVSHPFIIRMWGTFQDSQQVFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAK---YVPDV--TYTLCGTPDYIAPEVVSTKPYNKSVDWWSFGVLIYEMLAGYTPFYNSNTMKTYENILNAELKFPPFFHPDAQDLLKKLITRDLSERLGNLQNGSEDVKNHPWFNEVIWEKLLARYIETPYEPPIQQGQGDTSQFD 374

HSP 2 Score: 108.227 bits (269), Expect = 1.225e-25
Identity = 79/263 (30.04%), Postives = 129/263 (49.05%), Query Frame = 2

Query: 1370 IGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVE------ILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPF-TQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQ-----ILSHNW 2122
            +G GSF   +       G  YA+K +       +++VE       +    +HP I+++   +     V ++M+Y+EGGEL + +   + F    A      +   + YLH+  +++RDLKP NIL  K      ++ I DFGFAK       +  T C T +++APEV+  + Y+K+ D WS GVL++ ML+G TPF   N     E IL        +L    + H   +A+DLL K++  D ++R+   Q     + +H W
Sbjct:   94 LGTGSFGRVHLIRSNHNGRFYALKTLKKHTIVKLKQVEHTNDERRMLSIVSHPFIIRMWGTFQDSQQVFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNG----HIKITDFGFAKYVP---DVTYTLCGTPDYIAPEVVSTKPYNKSVDWWSFGVLIYEMLAGYTPFYNSNTMKTYENILNA------ELKFPPFFH--PDAQDLLKKLITRDLSERLGNLQNGSEDVKNHPW 341

[Close]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Yeast
Match: YPK1 (S/T protein kinase; phosphorylates, downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p by phosphorylation in response to compromised sphingolipid synthesis; involved in the TORC-dependent phosphorylation of ribosomal proteins Rps6a/b (S6); mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; human homolog SGK1 can complement a null mutant; human homolog SGK2 can complement a ypk1 ypk2 double mutant [Source:SGD;Acc:S000001609])

HSP 1 Score: 243.432 bits (620), Expect = 1.991e-70
Identity = 142/330 (43.03%), Postives = 204/330 (61.82%), Query Frame = 2

Query:  278 FELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDR-KRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPC-QPASATANEIFRGFSYVAPDVL 1261
            F+LL+V+G+GSFGKV  VRK    +   +YA+K ++K+ +  +     T  ER +LA +  PFIV L ++FQ+  K+Y +L F+ GG+LF  L KE  F     +FY AEL  ALD+LH L +VYRDLKPENILLD  GHI L DFGL K ++ +DD  +T +FCGT EY+APE++   G+  A DWW+ GVL++EMLTG  P+      +    IL+  L  P     +A+ LL  L  R+P+ R+G+   G +EI++ PFF  ++WK LL +   PP+KP  +   DTS FD +FT + P +S   +  S +  + F G++YV  + L
Sbjct:  347 FDLLKVIGKGSFGKVMQVRKKDTQK---VYALKAIRKSYIVSKSEVTHTLAERTVLARVDCPFIVPLKFSFQSPEKLYFVLAFINGGELFYHLQKEGRFDLSRARFYTAELLCALDNLHKLDVVYRDLKPENILLDYQGHIALCDFGLCKLNMKDDD--KTDTFCGTPEYLAPELLLGLGYTKAVDWWTLGVLLYEMLTGLPPYYDEDVPKMYKKILQEPLVFPDGFDRDAKDLLIGLLSRDPTRRLGY--NGADEIRNHPFFSQLSWKRLLMKGYIPPYKPAVSNSMDTSNFDEEFTREKPIDSVVDEYLSESVQKQFGGWTYVGNEQL 669

HSP 2 Score: 112.464 bits (280), Expect = 4.280e-26
Identity = 93/292 (31.85%), Postives = 141/292 (48.29%), Query Frame = 2

Query: 1352 YTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGT----KRDV---IEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTN---QILSHNWITFRSSLPSTKIAMNSDLSSVKGAV 2197
            + L + IGKGSF    +   K T   YA+K I  +    K +V   + E  +L R    P IV LK  +     +  ++ ++ GGEL  ++  +  F    A      L   +  LH   VV+RDLKP NIL   +     ++ +CDFG  K    ++    T C T  ++APE+L   GY KA D W+LGVLL+ ML+G  P+   + D P ++ K+I ++      G       +AKDLL+ +L  DP +R+  N   +I +H    F S L   ++ M   +   K AV
Sbjct:  347 FDLLKVIGKGSFGKVMQVRKKDTQKVYALKAIRKSYIVSKSEVTHTLAERTVLARVDC-PFIVPLKFSFQSPEKLYFVLAFINGGELFYHLQKEGRFDLSRARFYTAELLCALDNLHKLDVVYRDLKPENILLDYQG----HIALCDFGLCKLNMKDDDKTDTFCGTPEYLAPELLLGLGYTKAVDWWTLGVLLYEMLTGLPPYY--DEDVP-KMYKKILQEPLVFPDG----FDRDAKDLLIGLLSRDPTRRLGYNGADEIRNH---PFFSQLSWKRLLMKGYIPPYKPAV 623

[Close]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Yeast
Match: TPK1 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; phosphorylates and inhibits Whi3p to promote G1/S phase passage; partially redundant with Tpk2p and Tpk3p; phosphorylates pre-Tom40p, which impairs its import into mitochondria under non-respiratory conditions; TPK1 has a paralog, TPK3, that arose from the whole genome duplication [Source:SGD;Acc:S000003700])

HSP 1 Score: 232.261 bits (591), Expect = 3.061e-69
Identity = 132/319 (41.38%), Postives = 200/319 (62.70%), Query Frame = 2

Query:  206 FSQEEEATEVNAVDLVDEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKA-SLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPK-ATCLDDTSCFD 1156
            +++E+    +    +   K     F++LR LG GSFG+V L+R       G  YAMKVLKK   ++++  + T  ER +L+ + HPFI+ +   FQ+  ++++I+++++GG+LFS L K   F     KFY AE+ LAL++LHS  I+YRDLKPENILLD++GHIK+TDFG +K   Y  D   T++ CGT +Y+APEVV+ K +  + DWWSFG+L++EML G  PF  S+  +T   IL A+L  P F + + + LL  L  R+ S R+G    G E++K+ P+F+ + W+ LL+R +  P++P       DTS FD
Sbjct:   63 YNEEQYKQFIAQARVTSGKYSLQDFQILRTLGTGSFGRVHLIRSR---HNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAK---YVPDV--TYTLCGTPDYIAPEVVSTKPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPPFFNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWFKEVVWEKLLSRNIETPYEPPIQQGQGDTSQFD 373

HSP 2 Score: 112.079 bits (279), Expect = 5.971e-27
Identity = 78/265 (29.43%), Postives = 130/265 (49.06%), Query Frame = 2

Query: 1370 IGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVE------ILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPF-TQNEHDPPEEILK-RIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRI-----TTNQILSHNWI 2125
            +G GSF   +    +  G  YA+KV+       +++VE      ++     HP I+++   +     + +IM+Y+EGGEL + +   + F    A      +   + YLH+  +++RDLKP NIL  K      ++ I DFGFAK       +  T C T +++APEV+  + Y+K+ D WS G+L++ ML+G TPF   N     E+IL   +    F          + + KDLL +++  D +QR+      T  + +H W 
Sbjct:   93 LGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNG----HIKITDFGFAK---YVPDVTYTLCGTPDYIAPEVVSTKPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPPF---------FNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWF 341

[Close]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Yeast
Match: YPK2 (Protein kinase similar to S/T protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; involved in the TORC-dependent phosphorylation of ribosomal proteins Rps6a/b (S6); human homolog SGK2 can complement a ypk1 ypk2 double mutant [Source:SGD;Acc:S000004710])

HSP 1 Score: 238.039 bits (606), Expect = 1.338e-68
Identity = 140/330 (42.42%), Postives = 205/330 (62.12%), Query Frame = 2

Query:  278 FELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQ-DRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPC-QPASATANEIFRGFSYVAPDVL 1261
            F+LL+V+G+GSFGKV  VRK    +   +YA+K L+KA +  + +   T  ER +LA +  PFIV L ++FQ+  K+YL+L F+ GG+LF  L  E  F+    +FY+AEL  ALD LH L ++YRDLKPENILLD  GHI L DFGL K ++ ++D  +T +FCGT EY+APE++  +G+    DWW+ G+L++EM+TG  P+   +       IL+  L  P      A+ LL  L  R+PS R+G    G +EI++ PFF+ I+WK LL +   PP+KP      DT+ FD +FT + P +S   +  SA+  + F G++Y+  + L
Sbjct:  344 FDLLKVIGKGSFGKVMQVRKKDTQK---IYALKALRKAYIVSKCEVTHTLAERTVLARVDCPFIVPLKFSFQSPEKLYLVLAFINGGELFYHLQHEGRFSLARSRFYIAELLCALDSLHKLDVIYRDLKPENILLDYQGHIALCDFGLCKLNMKDND--KTDTFCGTPEYLAPEILLGQGYTKTVDWWTLGILLYEMMTGLPPYYDENVPVMYKKILQQPLLFPDGFDPAAKDLLIGLLSRDPSRRLGVN--GTDEIRNHPFFKDISWKKLLLKGYIPPYKPIVKSEIDTANFDQEFTKEKPIDSVVDEYLSASIQKQFGGWTYIGDEQL 666

HSP 2 Score: 114.005 bits (284), Expect = 1.467e-26
Identity = 79/258 (30.62%), Postives = 127/258 (49.22%), Query Frame = 2

Query: 1352 YTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAH--------PHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTN 2101
            + L + IGKGSF    +   K T   YA+K +   K  ++ + E+               P IV LK  +     + L++ ++ GGEL  ++  +  FS   +   +  L   +  LH   V++RDLKP NIL   +     ++ +CDFG  K    +N    T C T  ++APE+L  QGY K  D W+LG+LL+ M++G  P+  +E+ P   + K+I ++      G        AKDLL+ +L  DP++R+  N
Sbjct:  344 FDLLKVIGKGSFGKVMQVRKKDTQKIYALKAL--RKAYIVSKCEVTHTLAERTVLARVDCPFIVPLKFSFQSPEKLYLVLAFINGGELFYHLQHEGRFSLARSRFYIAELLCALDSLHKLDVIYRDLKPENILLDYQG----HIALCDFGLCKLNMKDNDKTDTFCGTPEYLAPEILLGQGYTKTVDWWTLGILLYEMMTGLPPY-YDENVP--VMYKKILQQPLLFPDG----FDPAAKDLLIGLLSRDPSRRLGVN 588

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BLAST of Ribosomal protein S6 kinase vs. Ensembl Yeast
Match: SCH9 (AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan [Source:SGD;Acc:S000001248])

HSP 1 Score: 235.728 bits (600), Expect = 9.304e-67
Identity = 148/348 (42.53%), Postives = 208/348 (59.77%), Query Frame = 2

Query:  278 FELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVL-KKASLKVQDRKRTKMERDIL---AAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPE-VVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQ-FLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTP----KESP---CQPASATANEIFRGFSYVAPDVLQHAQNAN 1282
            FE+LR+LG+G+FG+V+ V+K    +   +YAMKVL KK  +K  +   T  ER+IL   A+   PFIV L ++FQ    +YL+ +++ GG+LF  L KE  F+ED  KFY+AEL LAL+HLH   IVYRDLKPENILLD +G+I L DFGLSK  +     +RT +FCGT EY+APE +++  G+    D+WS GVL+FEM  G  PF   + ++    I   K+  P+  LS E ++ ++ L  RNP +R+G    G  E+++ PFF  I+W+ L  +K+ PPFKP      DTS FD +FT+ +     K  P     P S      F GF++V    +    N N
Sbjct:  412 FEVLRLLGKGTFGQVYQVKKKDTQR---IYAMKVLSKKVIVKKNEIAHTIGERNILVTTASKSSPFIVGLKFSFQTPTDLYLVTDYMSGGELFWHLQKEGRFSEDRAKFYIAELVLALEHLHDNDIVYRDLKPENILLDANGNIALCDFGLSKADL----KDRTNTFCGTTEYLAPELLLDETGYTKMVDFWSLGVLIFEMCCGWSPFFAENNQKMYQKIAFGKVKFPRDVLSQEGRSFVKGLLNRNPKHRLGAIDDG-RELRAHPFFADIDWEALKQKKIPPPFKPHLVSETDTSNFDPEFTTASTSYMNKHQPMMTATPLSPAMQAKFAGFTFVDESAIDEHVNNN 751

HSP 2 Score: 115.931 bits (289), Expect = 5.261e-27
Identity = 82/253 (32.41%), Postives = 127/253 (50.20%), Query Frame = 2

Query: 1370 IGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFG-----------AHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPE-VLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRI 2092
            +GKG+F   Y+   K T   YA+KV+  +K+ ++++ EI    G           + P IV LK  +     + L+ +Y+ GGEL  ++  +  FSE  A   +  L   + +LH N +V+RDLKP NIL    D N  N+ +CDFG +K    +     T C T  ++APE +L + GY K  D WSLGVL+F M  G +PF        E   K  +K +F       + +S E +  +  +L+ +P  R+
Sbjct:  418 LGKGTFGQVYQVKKKDTQRIYAMKVL--SKKVIVKKNEIAHTIGERNILVTTASKSSPFIVGLKFSFQTPTDLYLVTDYMSGGELFWHLQKEGRFSEDRAKFYIAELVLALEHLHDNDIVYRDLKPENILL---DAN-GNIALCDFGLSKADLKDR--TNTFCGTTEYLAPELLLDETGYTKMVDFWSLGVLIFEMCCGWSPFFA------ENNQKMYQKIAFGKVKFPRDVLSQEGRSFVKGLLNRNPKHRL 656

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BLAST of Ribosomal protein S6 kinase vs. Ensembl Nematostella
Match: EDO31895 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SWM6])

HSP 1 Score: 739.184 bits (1907), Expect = 0.000e+0
Identity = 376/597 (62.98%), Postives = 442/597 (74.04%), Query Frame = 2

Query:  257 EKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKISGWQNIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAK 2047
            +K D S FELL+VLGQGSFGKVFLVRKV     G LYAMKVLKKA+LKV+DR RT  ERDIL  ++HPFIV L+YAFQ EGKVYLIL+FL+GGDLF+RLSKE MFTE+DVKFYLAELALALDHLH LGI+YRDLKPENILLD  GH+ LTDFGLSKES ++    +T+SFCGTVEYMAPEVVNR+GH  AADWWS+GVLMFEMLTG LPFQG  RK+TM MILKAKL MPQFL+ EAQ+LLR LFKRNP NR+G G  GIE+IK  PFF  INW+ L  R++ PPFKP A   DD   FD +FTSKTP++SP  P SAT +++FRGFSYVAPD+++                    ++   +   Y +KEEIGKG++S C R V+K  G  YA+K+ +  K+D  EE+EIL RFG HP+IV L++ Y     V ++ME + GGELL  IL  K  SE+EA  I+Y LT T+ +LH   VVHRDLKPSNI+Y+     PE+L I DFGFAKQ RA NGLLMTPCYTANFVAPEVLKKQGYD A D+WSLGVLL+ MLSG TPF     D P  ILKRI +  + L GG W+  S  AK
Sbjct:    2 KKADPSQFELLKVLGQGSFGKVFLVRKVIGADAGTLYAMKVLKKATLKVRDRMRTMKERDILVDVQHPFIVRLNYAFQTEGKVYLILDFLRGGDLFTRLSKEIMFTEEDVKFYLAELALALDHLHGLGIIYRDLKPENILLDASGHVALTDFGLSKESEHD---QKTYSFCGTVEYMAPEVVNRRGHSQAADWWSYGVLMFEMLTGSLPFQGKDRKDTMNMILKAKLGMPQFLTPEAQSLLRQLFKRNPLNRLGAGDLGIEDIKKHPFFSTINWELLYKREIKPPFKPAAGRADDAFYFDPEFTSKTPQDSPAVPPSATCHQLFRGFSYVAPDIVEVETRGPA--------ARAFPIRTTCILDEYEIKEEIGKGAYSSCRRCVNKADGKEYAVKIFEKPKKDPSEEMEILLRFGHHPNIVHLRDAYEAGKQVYIVMELMRGGELLDRILKHKCLSEREAGNIMYTLTSTIAFLHEEGVVHRDLKPSNIMYADDSGTPESLRIVDFGFAKQMRATNGLLMTPCYTANFVAPEVLKKQGYDAACDIWSLGVLLYTMLSGLTPFAVGPEDTPSVILKRIGEGKYSLVGGPWDTASDLAK 587

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BLAST of Ribosomal protein S6 kinase vs. Ensembl Nematostella
Match: EDO39163 (Ribosomal protein S6 kinase [Source:UniProtKB/TrEMBL;Acc:A7SAZ2])

HSP 1 Score: 519.235 bits (1336), Expect = 4.623e-174
Identity = 303/722 (41.97%), Postives = 428/722 (59.28%), Query Frame = 2

Query:  233 VNAVDLVDEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASL--KVQDRKRTKMERDILAAIRH-PFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVV--NRKGHGTAADWWSFGVLMFEMLTGQLPF----QGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKISGWQNIVGVKFQK----VDH------------YYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKK----QGYDKASDVWSLGVLLFIMLSGKTPFTQNE---HDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDL------SSVKGAVKATYKAL--LEKSLPNLAPVANSTLAKRR 2278
            +N  +  DEK+   +FELLRVLG G++GKVFL RK      G L+AMKVLKKA++  K +  + T+ ER +L A+R  PF+VTLH+AFQ E K++LI++++ GG+LF+ L +   FTED+V+ Y+ E+ +ALDHLH LGI+YRD+K ENILLD+DGH+ LTDFGLSKE    +   R +SFCGT+EYMAPEVV    +GH  A DWWS GVLM+E+LTG  PF    + +S+ E    IL     MP  LS+EA  LL  L +++P  R+  G KG  E+K+ PFF+  +W DL  +++  PFKP+     D S F  +FT   P  SP      TA+ +FRG+S+VAP ++      N + ++     N V V+ +     VD+            Y    + +G GSFS C R VH  +G  YA+K+I   + D   EV+ L     HP+IV L +VY  +    L+ME L GGELL  I  +K F+E  AS I+  +   V ++H   VVHRDLKP N+L+     + E + I DFGFA   + E   L TPC+T ++ APEVL +     GYD++ D+WSLGV+L+ MLSG+ PF  +          +++RI +   +  G QW+ IS +AKDL+  +L  DP+QR+T  ++L H+W+   +SLP T +     L      + V+ A+  TY A    ++    L  V N+ LAKRR
Sbjct:    1 MNLTEAQDEKVGIENFELLRVLGTGAYGKVFLARKRGGHHDGRLFAMKVLKKATIVQKAKTAEHTRTERQVLEAVRRCPFLVTLHWAFQTEAKLHLIMDYVNGGELFTHLYQREKFTEDEVRLYIGEIVVALDHLHQLGIIYRDIKLENILLDKDGHVVLTDFGLSKEFAAPNSGERAYSFCGTIEYMAPEVVKGGSRGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQSEISKRILHNNPPMPHDLSAEAIDLLHKLLQKDPKKRL--GAKGAHELKAHPFFKAFDWADLAEKRIPAPFKPRIRDELDVSNFSEEFTDMAPTYSPA-AVPKTADRVFRGYSFVAPSIIFGENEFNQQPVQRKNEVNAVPVQRRPAQGLVDYASMFEGSHFFQNYRITSQVLGDGSFSTCRRCVHLRSGQEYAVKII-SRRCDHTREVQSLKMCHGHPNIVTLYDVYQDEFHTYLVMELLAGGELLERIRKKKMFTESAASVIMRKIVSAVEFMHQRGVVHRDLKPENLLFVDNSEDAE-IKIVDFGFAC-VKPEAQQLQTPCFTLSYAAPEVLDQTVSNSGYDESCDLWSLGVILYTMLSGQVPFQSSGSWYKSSTGFVMQRITQGDVRFDGQQWQSISPQAKDLIQGLLTVDPSQRLTVQEVLRHDWLRVETSLPHTPLVTPGILERGKKRTYVESALNVTYNAFNKAQRQGFTLMDVENAPLAKRR 716

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BLAST of Ribosomal protein S6 kinase vs. Ensembl Nematostella
Match: EDO41166 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S521])

HSP 1 Score: 351.673 bits (901), Expect = 1.139e-113
Identity = 191/378 (50.53%), Postives = 258/378 (68.25%), Query Frame = 2

Query:  167 NEVEVDEEFSDNAFSQE----EEATEV-----NAVDLVDEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASL--KVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPA-SATANEIFRGFSYVAPDVLQ 1264
            +E+  D+EF +     E    +E  E        V+  DEK+    FELL+VLG+G +GKVFLV+K     +  ++AMKVLKKA++    +D   TK ER+IL  ++HPFIV L YAFQ  GK+YLILE+L GG+LF +L +E +F ED   FYL+E+++AL+HLH  GIVYRDLKPENILLD +GH+KLTDFGL KESI+ +  + T +FCGT+EYMAPE++ R GHG A DWWS G LM++MLTG  PF   +RK+T+  ILK KL +P +L+ EA+  +R L KR+P  R+G        IK+  FF+ I W+DLL +KV PPF+P  +  +D S FDS+FT +TP +SP     S +A+ IF+GF+YVAP VL+
Sbjct:   19 DELSSDDEFDEGQVYDEPMDGDERMETLQLSEETVNPKDEKVGPESFELLKVLGKGGYGKVFLVKKNHGHSKEKIFAMKVLKKAAIIRSQKDTAHTKAERNILECVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFLEDTACFYLSEISMALEHLHKQGIVYRDLKPENILLDANGHVKLTDFGLCKESIFEN--SLTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMYDMLTGTPPFCADNRKKTIDKILKGKLIIPPYLTPEAKDFIRKLLKRHPQARLGGMAGDANPIKAHSFFRHICWEDLLAKKVEPPFRPSISGEEDVSQFDSKFTRQTPVDSPDDSMLSESASNIFQGFTYVAPSVLE 394

HSP 2 Score: 115.161 bits (287), Expect = 2.318e-27
Identity = 75/228 (32.89%), Postives = 118/228 (51.75%), Query Frame = 2

Query: 1454 TKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRI-----TTNQILSHNW 2122
             +R+++E V+       HP IV L   +     + LI+EYL GGEL   +  +  F E  A   L  ++  + +LH   +V+RDLKP NIL    D N  ++ + DFG  K+   EN L  T C T  ++APE+L + G+ KA D WSLG L++ ML+G  PF  +     ++ + +I K    +      +++ EAKD + K+L   P  R+       N I +H++
Sbjct:  116 AERNILECVK-------HPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFLEDTACFYLSEISMALEHLHKQGIVYRDLKPENILL---DAN-GHVKLTDFGLCKESIFENSLTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMYDMLTGTPPFCADNR---KKTIDKILKGKLIIP----PYLTPEAKDFIRKLLKRHPQARLGGMAGDANPIKAHSF 325

[Close]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Nematostella
Match: EDO37800 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SEW2])

HSP 1 Score: 244.202 bits (622), Expect = 4.860e-73
Identity = 139/357 (38.94%), Postives = 211/357 (59.10%), Query Frame = 2

Query:  221 EATEVNAVDLVDE---KLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKM-ERDILAA-IRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASAT--------ANEIFRGFSYVAP 1252
            +  +V  +DL +    K   S F  L+V+G+GSFGKVFL +   E +    YA+KVL K++++ ++  +  M ER++L   + HPF+V LHY+FQ + K+Y +L+++ GG+LF  L +E  F E   +FY AE+A A+ +LH L I+YRDLKPENILLD  GHI LTDFGL KE I  D +  T +FCGT EY+APEV+ ++ +  + DWW  G +++EM+ G  PF      E    IL   L +   +S  A+ +L  L +++ + R+G G    E+I++  FF+ INW+ L+ R + PP+ P  +   D   FD +F  +    S  + A +          ++ F GF+YVAP
Sbjct:   52 DDADVEKIDLGESNNPKAKPSDFLFLKVIGKGSFGKVFLSKNKQEDK---FYAIKVLNKSAIRKRNEAKHIMAERNVLVQNVTHPFLVGLHYSFQTKDKLYFVLDYVNGGELFFHLQRERYFPESRARFYAAEIASAIGYLHGLQIIYRDLKPENILLDSKGHIVLTDFGLCKEGI--DRSGTTSTFCGTPEYLAPEVLRKQDYDKSVDWWCLGAVLYEMMYGLPPFYSRDTAEMYDNILHKPLRLRTNISQSARHILEGLLQKDKTKRLGSGEGDFEDIRTHSFFRSINWQQLVARGIEPPYNPNVSGQLDLKHFDPEFVREPVPGSVGKSADSNFVSASVDDPDDAFVGFTYVAP 403

HSP 2 Score: 130.568 bits (327), Expect = 1.520e-32
Identity = 85/268 (31.72%), Postives = 140/268 (52.24%), Query Frame = 2

Query: 1370 IGKGSFSVCYRAVHKTTGVNYAIKVIDGT---KRD----VIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQ-----ILSHNWITFRS 2137
            IGKGSF   + + +K     YAIKV++ +   KR+    ++ E  +L +   HP +V L   +  ++ +  +++Y+ GGEL  ++  ++YF E  A      +   + YLH   +++RDLKP NIL   K     ++V+ DFG  K+    +G   T C T  ++APEVL+KQ YDK+ D W LG +L+ M+ G  PF   +     E+   I  K  +L      +IS  A+ +L  +L  D  +R+ + +     I +H++  FRS
Sbjct:   80 IGKGSFGKVFLSKNKQEDKFYAIKVLNKSAIRKRNEAKHIMAERNVLVQNVTHPFLVGLHYSFQTKDKLYFVLDYVNGGELFFHLQRERYFPESRARFYAAEIASAIGYLHGLQIIYRDLKPENILLDSKG----HIVLTDFGLCKEGIDRSGTTSTFCGTPEYLAPEVLRKQDYDKSVDWWCLGAVLYEMMYGLPPFYSRD---TAEMYDNILHKPLRLR----TNISQSARHILEGLLQKDKTKRLGSGEGDFEDIRTHSF--FRS 334

[Close]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Nematostella
Match: EDO35585 (Protein kinase C [Source:UniProtKB/TrEMBL;Acc:A7SL27])

HSP 1 Score: 244.202 bits (622), Expect = 4.935e-70
Identity = 138/340 (40.59%), Postives = 207/340 (60.88%), Query Frame = 2

Query:  251 VDEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKAS-LKVQDRKRTKMERDILA-AIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIE-EIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATAN---EIFRGFSYVAP 1252
            V  K+    F  ++VLG+GSFGKV L  +    +   +YA+K+LKK S L+  D + T +ER +LA +  HPF+ +LH +FQ   +++ ++E++ GGDL  ++ K   F E+  +FY AE+ LAL  LH  G++YRDLK +N+LLD DGHIKL DFG+ KE++       T +FCGT +Y+APE++  + +G + DWW+ GVLM+EM+ GQ PF+  + ++    IL   +  P +LS EA ++L+    +N   R+G  P   E  I+   FF+LIN++ L  R++ PPFKPK     D   FD+ FT + PK +P    +   N     FRGFS+V P
Sbjct:  374 VLRKMTLKDFTFIKVLGKGSFGKVLLAERKGTDE---VYAIKILKKESVLQDDDVECTMIERRVLALSAGHPFLTSLHSSFQTVERLFFVMEYVNGGDLMFQIQKSRKFDENRSRFYAAEVVLALQFLHQNGVIYRDLKLDNVLLDADGHIKLADFGMCKENMA--PGKTTTTFCGTPDYIAPEILQEQPYGFSVDWWALGVLMYEMMAGQPPFEAENEEDLFESILHDDVLYPVWLSREAVSILKGFMTKNYLKRLGCTPTSTESSIREHAFFRLINFEKLEARQINPPFKPKIRSRTDVGNFDTDFTKEEPKLTPTD-RNVIVNIDQREFRGFSFVNP 707

HSP 2 Score: 110.153 bits (274), Expect = 6.350e-25
Identity = 69/218 (31.65%), Postives = 110/218 (50.46%), Query Frame = 2

Query: 1352 YTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVI--------DGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPF-TQNEHDPPEEIL 1978
            +T  + +GKGSF     A  K T   YAIK++        D  +  +IE   +L     HP +  L   +     +  +MEY+ GG+L+  I   + F E  +      +   + +LH N V++RDLK  N+L         ++ + DFG  K+  A      T C T +++APE+L++Q Y  + D W+LGVL++ M++G+ PF  +NE D  E IL
Sbjct:  383 FTFIKVLGKGSFGKVLLAERKGTDEVYAIKILKKESVLQDDDVECTMIER-RVLALSAGHPFLTSLHSSFQTVERLFFVMEYVNGGDLMFQIQKSRKFDENRSRFYAAEVVLALQFLHQNGVIYRDLKLDNVLLDADG----HIKLADFGMCKENMAPGKTTTTFCGTPDYIAPEILQEQPYGFSVDWWALGVLMYEMMAGQPPFEAENEEDLFESIL 595

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BLAST of Ribosomal protein S6 kinase vs. Ensembl Medaka
Match: ENSORLT00000003187.2 (ribosomal protein S6 kinase alpha-3 [Source:NCBI gene;Acc:101165012])

HSP 1 Score: 855.514 bits (2209), Expect = 0.000e+0
Identity = 441/744 (59.27%), Postives = 533/744 (71.64%), Query Frame = 2

Query:  122 MPLGPVTDSFHI-----SNLNEVEVDEEFS---DNAFSQEEEATEVNAVDLV------DEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVA--PDVLQHAQNANIEDMKISGWQNIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKALLEKSLPNLAPVANSTLAKRRGQSKPKSST 2305
            MPL  + D +       ++  E   D+E S   D++ S   +   +  +++        EK D   FEL +VLGQGSFGKVFLVRK++ P  G LYAMKVLKKA+LKV+DR RTKMERDIL  + HPFIV LHYAFQ EGK+YLIL+FL+GGDLF+RLSKE MFTE+DVKFYLAELALALDHLH LGI+YRDLKPENILLDEDGHIKLTDFGLSKESI  D  N+ +SFCGTVEYMAPEVVNR+GH  +ADWWS+GVLMFEMLTG LPFQG  RKETMTMILKAKL MPQFLSSEAQ+LLR LFKRNP NR+G GP G+EEIK   FF  I+W  L  R++ PPFKP     DDT  FD +FT+KTP++SP  P SA A+++FRGFS+VA   +  Q   +A ++ +  +  Q             Y +KE+IG GS+S+C R +HK TG+ YA+K+I+  KRD  EEVEIL R+G HP+++ LK+VY    +V L+ E ++GGELL  IL QK+FSE+EAS +LY +T+TV YLH   VVHRDLKPSNILY  +  N E++ ICDFGF+KQ RAENGLLMTPCYTANFVAPEVLKKQGYD A D+WSLGVLL+ ML+G TPF     D PEEIL RI   +F LTGG W  +S+EAKDL+ KMLH DP +R+T  Q+L H W+  R  LP   +        VK A+ ATY AL     P L PV  S+LA+RRG  K  S+ 
Sbjct:    1 MPLAQLADPWQKMPVEGTSGEEAHPDQEDSVTEDDSMSTSTDDASIKEINITHHVKEGSEKGDPRQFELRKVLGQGSFGKVFLVRKITGPDAGQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHGLGIIYRDLKPENILLDEDGHIKLTDFGLSKESI--DHENKAYSFCGTVEYMAPEVVNRRGHTHSADWWSYGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSSEAQSLLRNLFKRNPGNRLGAGPDGVEEIKRHHFFHTIDWNKLFRREIYPPFKPAVGRPDDTFYFDPEFTAKTPRDSPGVPPSANAHQLFRGFSFVAITEEETQPLPHAIVQQLHRNNSQ---------FSDSYEIKEDIGVGSYSICKRCIHKATGMEYAVKIINKAKRDPTEEVEILLRYGQHPNVITLKDVYDDGRSVFLVTELMKGGELLDKILRQKFFSEREASAVLYTITKTVEYLHVQGVVHRDLKPSNILYVDESGNAESIRICDFGFSKQLRAENGLLMTPCYTANFVAPEVLKKQGYDAACDIWSLGVLLYTMLTGFTPFANGPEDTPEEILARIGSGNFSLTGGNWNTVSAEAKDLVSKMLHVDPHKRLTAGQVLRHPWVMHRDQLPKYTLNRQDTPLLVKAAMAATYSALSRNVPPVLEPVGCSSLARRRGAKKITSTA 733

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BLAST of Ribosomal protein S6 kinase vs. Ensembl Medaka
Match: rps6kal (highly divergent homeobox [Source:NCBI gene;Acc:101174679])

HSP 1 Score: 847.81 bits (2189), Expect = 0.000e+0
Identity = 434/708 (61.30%), Postives = 528/708 (74.58%), Query Frame = 2

Query:  197 DNAFSQEEEAT--EVNAVDLVDE---KLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKISGWQNIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKALLEK-SLPNLAPVANSTLAKRRGQSKPKSS 2302
            D+A ++E+E T  E+     V E   K D S FELL+VLGQGSFGKVFLVRK+  P    LYAMKVLKKASLKV+DR RTKMERDIL  + HPFIV LHYAFQ EGK+YLIL+FL+GGD+F+RLSKE MFTE+DVKFYLAELALALDHLHSLGIVYRDLKPENILLDE GHIKLTDFGLSKES+  D   + +SFCGTVEYMAPEVVNR+GH  +ADWWS GVLMFEMLTG LPFQG  R ETM MILKAKL MPQFLS EAQ+LLR+LFKRNP+NR+G G  G+EEIK   FF  I+W  L  R++ PPFKP A   DDT CFD +FT+KTPK+SP  P SA A+++F+GFS+VAP  +  ++++ +  +      +    KF  +   Y L+E+IG GS+S+C R VH+ + + YA+K+ID +KRD  EE+EIL R+G HP+I+ LK+VY +   V L+ E ++GGELL  IL QK+FSE+EAS +LY +T+TV YLH   VVHRDLKPSNILY     NP+++ ICDFGFAKQ R  NGLL+TPCYTANFVAPEVL +QGYD A D+WSLGVLL+ ML+G TPF    +D PEEIL RI    F LTGG W+ +S  +KDLL  MLH DP QR T  Q+L H+WIT +++LP  ++  +     VKGA+ ATY AL +K S P L PVA S+LA+RR   K  S+
Sbjct:   79 DDATTEEDEGTYKEIPITHHVKEGCEKADPSQFELLKVLGQGSFGKVFLVRKLVGPDASQLYAMKVLKKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIVYRDLKPENILLDEAGHIKLTDFGLSKESV--DADKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSLGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSLEAQSLLRMLFKRNPANRLGAGSDGVEEIKRHAFFSTIDWNKLYRRELQPPFKPAAGKPDDTFCFDPEFTAKTPKDSPGIPPSANAHQLFKGFSFVAPAPMDESKSSPMLSILPIVQMHGGSAKFSDL---YELQEDIGVGSYSICKRCVHQVSAMEYAVKIIDKSKRDPSEEIEILMRYGQHPNIITLKDVYDEGRYVYLVTELMKGGELLDRILRQKFFSEREASAVLYTITKTVDYLHCQGVVHRDLKPSNILYMDDSGNPDSIRICDFGFAKQLRGGNGLLLTPCYTANFVAPEVLMRQGYDAACDIWSLGVLLYTMLAGYTPFANGPNDTPEEILLRIGSGKFSLTGGNWDTVSDSSKDLLSHMLHVDPHQRYTAEQVLKHSWITCKNTLPHFQLTRHDAPHLVKGAMAATYSALSQKTSQPVLEPVAASSLAQRRSMKKLTST 781

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BLAST of Ribosomal protein S6 kinase vs. Ensembl Medaka
Match: rps6kal (highly divergent homeobox [Source:NCBI gene;Acc:101174679])

HSP 1 Score: 845.499 bits (2183), Expect = 0.000e+0
Identity = 433/711 (60.90%), Postives = 526/711 (73.98%), Query Frame = 2

Query:  173 VEVDEEFSDNAFSQEEEATEVNAVDLVDEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKISGWQNIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKALLEK-SLPNLAPVANSTLAKRRGQSKPKSS 2302
            +E  E FS+      +E    + V    EK D S FELL+VLGQGSFGKVFLVRK+  P    LYAMKVLKKASLKV+DR RTKMERDIL  + HPFIV LHYAFQ EGK+YLIL+FL+GGD+F+RLSKE MFTE+DVKFYLAELALALDHLHSLGIVYRDLKPENILLDE GHIKLTDFGLSKES+  D   + +SFCGTVEYMAPEVVNR+GH  +ADWWS GVLMFEMLTG LPFQG  R ETM MILKAKL MPQFLS EAQ+LLR+LFKRNP+NR+G G  G+EEIK   FF  I+W  L  R++ PPFKP A   DDT CFD +FT+KTPK+SP  P SA A+++F+GFS+VAP  +  ++++ +  +      +    KF  +   Y L+E+IG GS+S+C R VH+ + + YA+K+ID +KRD  EE+EIL R+G HP+I+ LK+VY +   V L+ E ++GGELL  IL QK+FSE+EAS +LY +T+TV YLH   VVHRDLKPSNILY     NP+++ ICDFGFAKQ R  NGLL+TPCYTANFVAPEVL +QGYD A D+WSLGVLL+ ML+G TPF    +D PEEIL RI    F LTGG W+ +S  +KDLL  MLH DP QR T  Q+L H+WIT +++LP  ++  +     VKGA+ ATY AL +K S P L PVA S+LA+RR   K  S+
Sbjct:   20 MEEGESFSNCDEGTYKEIPITHHVKEGCEKADPSQFELLKVLGQGSFGKVFLVRKLVGPDASQLYAMKVLKKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIVYRDLKPENILLDEAGHIKLTDFGLSKESV--DADKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSLGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSLEAQSLLRMLFKRNPANRLGAGSDGVEEIKRHAFFSTIDWNKLYRRELQPPFKPAAGKPDDTFCFDPEFTAKTPKDSPGIPPSANAHQLFKGFSFVAPAPMDESKSSPMLSILPIVQMHGGSAKFSDL---YELQEDIGVGSYSICKRCVHQVSAMEYAVKIIDKSKRDPSEEIEILMRYGQHPNIITLKDVYDEGRYVYLVTELMKGGELLDRILRQKFFSEREASAVLYTITKTVDYLHCQGVVHRDLKPSNILYMDDSGNPDSIRICDFGFAKQLRGGNGLLLTPCYTANFVAPEVLMRQGYDAACDIWSLGVLLYTMLAGYTPFANGPNDTPEEILLRIGSGKFSLTGGNWDTVSDSSKDLLSHMLHVDPHQRYTAEQVLKHSWITCKNTLPHFQLTRHDAPHLVKGAMAATYSALSQKTSQPVLEPVAASSLAQRRSMKKLTST 725

[Close]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Medaka
Match: rps6ka1 (ribosomal protein S6 kinase 2 alpha [Source:NCBI gene;Acc:101169648])

HSP 1 Score: 843.573 bits (2178), Expect = 0.000e+0
Identity = 435/739 (58.86%), Postives = 537/739 (72.67%), Query Frame = 2

Query:  122 MPLGPVTDSFHISNLNEVEVD------EEFSDNAFSQEEEATEVNAVDLV---DEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKISGWQNIVGVKFQKV--DHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKALL-EKSLPNLAPVANSTLAKRRGQSKPKSS 2302
            MPL  + + +    L ++E +      E+   NA  ++ +  E N  ++V    EK D+S FELL+VLGQGSFGKVFLVRKV+ P    LYAMKVLKKA+LKV+DR RTKMERDILA + HPF+V LHYAFQ EGK+YLIL+FL+GGDLF+RLSKE MFTE+DVKFYLAELAL LDHLHSLGI+YRDLKPENILLDE+GHIKLTDFGL KE+I  D   + +SFCGTVEYMAPEVVNR+GH  +ADWWSFGVLMFEMLTG LPFQG  RKETM +ILKA+L MPQFLS+EAQ+LLR LFKRNPSNR+G G  G EEIK   FF  I+W  L  +++ PPF+P     DDT  FDS+FTS+TPK+SP  P SA A+++FRGFS+VA  +L+  ++ ++E  +      +  +  + +     Y LKE+IG GSFSVC R +HK T   YA+KVID T  D  EE++IL R+G HP+I+ LK+VY     V L+ E + GGELL  IL QK+FSE+EAS +L+ +T+TV YLH+  VVHRDLKPSNILY  +  NPE++ ICDFGFAKQ RA NGLLMTPCYTANFVAPEVLK+QGYD+  D+WSLGVLL+ ML+G TPF     D P EIL RI    F L GG W+ +S  AKDL+ KMLH DP QR+T  Q+L H WI  R  LP++++  + D   VKGA+ ATY AL   +  P L P+ +S LA+RR +  P +S
Sbjct:    1 MPLAQIAEPWPQMELVQLETENGQSTTEDGVTNADKEDGDVKEYNITNVVKEGSEKADASQFELLKVLGQGSFGKVFLVRKVTPPDANQLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLCKEAI--DHEKKAYSFCGTVEYMAPEVVNRQGHTHSADWWSFGVLMFEMLTGALPFQGKDRKETMNLILKARLGMPQFLSAEAQSLLRALFKRNPSNRLGSGADGAEEIKRHGFFATIDWNKLFRKELKPPFRPAVARPDDTFYFDSEFTSRTPKDSPGVPPSAGAHQLFRGFSFVASTMLE--EDGSVEPPQPPPHPVVKQLHGKNLLFSDGYVLKEDIGMGSFSVCKRCIHKATNTEYAVKVIDKTSTDPSEEIDILLRYGQHPNIITLKDVYDNGKQVFLVTELMRGGELLDRILKQKFFSEREASAVLHTITKTVEYLHSQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRANNGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGVLLYTMLAGFTPFANGPEDTPNEILNRIGNGHFSLNGGNWDTVSDAAKDLVSKMLHVDPLQRLTAKQVLKHPWIVQREKLPNSQLP-HQDPKLVKGAMAATYSALKNSQPTPELKPIESSFLAQRRVKKLPSTS 734

[Close]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Medaka
Match: rps6ka1 (ribosomal protein S6 kinase 2 alpha [Source:NCBI gene;Acc:101169648])

HSP 1 Score: 840.877 bits (2171), Expect = 0.000e+0
Identity = 429/713 (60.17%), Postives = 527/713 (73.91%), Query Frame = 2

Query:  182 DEEFSDNAFSQEEEATEVNAVDLV---DEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKISGWQNIVGVKFQKV--DHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKALL-EKSLPNLAPVANSTLAKRRGQSKPKSS 2302
            D +   N ++++ +  E N  ++V    EK D+S FELL+VLGQGSFGKVFLVRKV+ P    LYAMKVLKKA+LKV+DR RTKMERDILA + HPF+V LHYAFQ EGK+YLIL+FL+GGDLF+RLSKE MFTE+DVKFYLAELAL LDHLHSLGI+YRDLKPENILLDE+GHIKLTDFGL KE+I  D   + +SFCGTVEYMAPEVVNR+GH  +ADWWSFGVLMFEMLTG LPFQG  RKETM +ILKA+L MPQFLS+EAQ+LLR LFKRNPSNR+G G  G EEIK   FF  I+W  L  +++ PPF+P     DDT  FDS+FTS+TPK+SP  P SA A+++FRGFS+VA  +L+  ++ ++E  +      +  +  + +     Y LKE+IG GSFSVC R +HK T   YA+KVID T  D  EE++IL R+G HP+I+ LK+VY     V L+ E + GGELL  IL QK+FSE+EAS +L+ +T+TV YLH+  VVHRDLKPSNILY  +  NPE++ ICDFGFAKQ RA NGLLMTPCYTANFVAPEVLK+QGYD+  D+WSLGVLL+ ML+G TPF     D P EIL RI    F L GG W+ +S  AKDL+ KMLH DP QR+T  Q+L H WI  R  LP++++  + D   VKGA+ ATY AL   +  P L P+ +S LA+RR +  P +S
Sbjct:   40 DTDEPTNLWTEDGDVKEYNITNVVKEGSEKADASQFELLKVLGQGSFGKVFLVRKVTPPDANQLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLCKEAI--DHEKKAYSFCGTVEYMAPEVVNRQGHTHSADWWSFGVLMFEMLTGALPFQGKDRKETMNLILKARLGMPQFLSAEAQSLLRALFKRNPSNRLGSGADGAEEIKRHGFFATIDWNKLFRKELKPPFRPAVARPDDTFYFDSEFTSRTPKDSPGVPPSAGAHQLFRGFSFVASTMLE--EDGSVEPPQPPPHPVVKQLHGKNLLFSDGYVLKEDIGMGSFSVCKRCIHKATNTEYAVKVIDKTSTDPSEEIDILLRYGQHPNIITLKDVYDNGKQVFLVTELMRGGELLDRILKQKFFSEREASAVLHTITKTVEYLHSQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRANNGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGVLLYTMLAGFTPFANGPEDTPNEILNRIGNGHFSLNGGNWDTVSDAAKDLVSKMLHVDPLQRLTAKQVLKHPWIVQREKLPNSQLP-HQDPKLVKGAMAATYSALKNSQPTPELKPIESSFLAQRRVKKLPSTS 747

[Close]

BLAST of Ribosomal protein S6 kinase vs. Planmine SMEST
Match: SMESG000059433.1 (SMESG000059433.1)

HSP 1 Score: 1481.46 bits (3834), Expect = 0.000e+0
Identity = 729/730 (99.86%), Postives = 729/730 (99.86%), Query Frame = 2

Query:  122 MPLGPVTDSFHISNLNEVEVDEEFSDNAFSQEEEATEVNAVDLVDEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKISGWQNIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKALLEKSLPNLAPVANSTLAKRRGQSKPKSSTEI 2311
            MPLGPVTDSFHISNLNEVEVDEEFSDNAFSQEEEATEVNAVDLVDEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYLAELALALDHLHSLGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQN NIEDMKISGWQNIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKALLEKSLPNLAPVANSTLAKRRGQSKPKSSTEI
Sbjct:    1 MPLGPVTDSFHISNLNEVEVDEEFSDNAFSQEEEATEVNAVDLVDEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYLAELALALDHLHSLGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNTNIEDMKISGWQNIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKALLEKSLPNLAPVANSTLAKRRGQSKPKSSTEI 730

[Close]

BLAST of Ribosomal protein S6 kinase vs. Planmine SMEST
Match: SMESG000077749.1 (SMESG000077749.1)

HSP 1 Score: 482.256 bits (1240), Expect = 4.660e-163
Identity = 244/470 (51.91%), Postives = 325/470 (69.15%), Query Frame = 2

Query:  941 MPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPK-ESPCQPASATANEIFRGFSYVAPDVLQHA---QNANIEDMKISG-------WQN-------IVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKAL-LEKSLPNLAPVANST-LAKRRGQSK 2290
            MPQFLS EAQ+LLR LFKRNP+NR+G+GP GI+++KS PFF  INW  L NR+++PPFKP  + LDD   FDS+F+ K  K +SP  P+SA+A ++F+GFS+VAP VL ++   QN N     IS        +QN         GVK +     Y +KE IG G++S+C + +HK T + YA+K+ID  + +  +EVEIL RF   P++V L++VY   + V ++ EYL GGELL  I+ QK+F+E+EAS I+ V+ +T+ +LH NLVVHRDLKPSN++Y+ +D NPE+L ICDFGFAKQ +AENGLLMTPCYTANFVAPEVLK QGY  A D+WSLGVLL+ ML G+TPF QN  D P  IL+RIE   F +TGG W+ IS   KDL+ KMLH DP+QR+T + IL+H WI     LP  ++ +  +   +K A+ AT+ AL L+ +   L PV++S  LAKRR + K
Sbjct:    1 MPQFLSPEAQSLLRALFKRNPTNRLGYGPNGIDDLKSHPFFCTINWTQLYNRQISPPFKPVCSPLDDAFYFDSEFSIKQLKTDSPGVPSSASATDLFKGFSFVAPIVLNNSNPEQNVNNHSNGISTNTSTIAQYQNGNSTLSKKSGVKTKPFLQDYDIKEVIGHGTYSLCRKCIHKQTNLVYAVKIIDRERCEPYDEVEILMRFHNLPNVVCLRDVYDNGSHVYIVTEYLRGGELLDKIIKQKFFAEREASSIIAVVAKTLSHLHQNLVVHRDLKPSNLVYADEDGNPESLKICDFGFAKQLKAENGLLMTPCYTANFVAPEVLKMQGYAAACDIWSLGVLLYTMLVGRTPFAQNNTDSPNTILRRIEGGEFNMTGGNWDAISPAGKDLVAKMLHVDPSQRLTADGILTHTWIKNGDQLPQYRLIIGQNGFEIKDAMHATFTALNLKSTSLQLEPVSSSGLLAKRREKKK 470

HSP 2 Score: 110.538 bits (275), Expect = 3.483e-25
Identity = 70/224 (31.25%), Postives = 123/224 (54.91%), Query Frame = 2

Query:  278 FELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRTKMERDILAAIRH---PFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILL-DEDGH---IKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILK 928
            +++  V+G G++    L RK    Q  ++YA+K++        DR+R +   ++   +R    P +V L   + N   VY++ E+L+GG+L  ++ K+  F E +    +A +A  L HLH   +V+RDLKP N++  DEDG+   +K+ DFG +K+     +     + C T  ++APEV+  +G+  A D WS GVL++ ML G+ PF  ++     T++ +
Sbjct:  156 YDIKEVIGHGTYS---LCRKCIHKQTNLVYAVKII--------DRERCEPYDEVEILMRFHNLPNVVCLRDVYDNGSHVYIVTEYLRGGELLDKIIKQKFFAEREASSIIAVVAKTLSHLHQNLVVHRDLKPSNLVYADEDGNPESLKICDFGFAKQ--LKAENGLLMTPCYTANFVAPEVLKMQGYAAACDIWSLGVLLYTMLVGRTPFAQNNTDSPNTILRR 366

[Close]

BLAST of Ribosomal protein S6 kinase vs. Planmine SMEST
Match: SMESG000068122.1 (SMESG000068122.1)

HSP 1 Score: 318.931 bits (816), Expect = 1.653e-100
Identity = 176/388 (45.36%), Postives = 250/388 (64.43%), Query Frame = 2

Query:  164 LNEVEVDEEFSDNAFSQEEEATEVNAVDLVDE-------KLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASL---KVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANE----IFRGFSYVAPDV-LQHAQNAN 1282
            +N +E++   SDN    E ++T   +VD+ +E       K+ S  F+LL+ LG+G +G+VFL +KV+    G  +AMKV+KKA L   K  D K    ER+IL A+ HPF+V L++AFQ    ++L+LE+L GG+LF +L ++   TED+ +FYLAE  LAL HLHS+G++YRDLK EN++LD  GH+KLTDFGLSKE   NDD   T SFCGTVEYMAPE++ R+GHG + DWWS G+L+++ML G  PF G +R + +  +  AKL +P+FL+   + LL+ L  +NP  R+G G K +EEIK   FF+ INW   L R++ PPF P+ +  DD S FD    S+     PC  +  T ++     F  FSYV+P V L+ ++N +
Sbjct:   25 INGIELEANDSDNLNKDEYDSTS-KSVDICEETVNPPGVKVTSHDFDLLKKLGKGGYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER--NDD-ELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGKHLLKNLLNKNPKARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSE-----PCMISPTTTDDSNCYWFENFSYVSPQVYLELSENGS 403

HSP 2 Score: 108.227 bits (269), Expect = 1.168e-24
Identity = 75/278 (26.98%), Postives = 139/278 (50.00%), Query Frame = 2

Query: 1313 NIVGVKFQKVDHYYTLKEEIGKGSFSVCYRAVH---KTTGVNYAIKVIDG---------------TKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRI 2092
            N  GVK     H + L +++GKG +   + A        G  +A+KV+                 T+R+++E V        HP +VKL   +   +++ L++EYL GGEL   +  Q   +E EA   L   T  + +LH+  V++RDLK  N++  +      ++ + DFG +K +R ++ L  + C T  ++APE+L+++G+  + D WS+G+LL+ ML G +PF         ++++++     ++       ++   K LL  +L+ +P  R+
Sbjct:   58 NPPGVKV--TSHDFDLLKKLGKGGYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVN-------HPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYG----HVKLTDFGLSK-ERNDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNR---SQVIQKVTNAKLKIP----RFLTDSGKHLLKNLLNKNPKARL 314

[Close]

BLAST of Ribosomal protein S6 kinase vs. Planmine SMEST
Match: SMESG000004478.1 (SMESG000004478.1)

HSP 1 Score: 320.857 bits (821), Expect = 6.592e-100
Identity = 178/392 (45.41%), Postives = 254/392 (64.80%), Query Frame = 2

Query:  143 DSFHISNLNEVEVDEEFSDNAFSQEEEATEVNAVDLVDE------KLDSSHFELLRVLGQGSFGKVFLVRKVSEPQ-QGILYAMKVLKKASL--KVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPF-QGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQL--INWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESP--CQPASATANEIFRGFSYVAPDVLQHAQN 1276
            D   +S  +E+ + ++F  N   + EE  ++ +V++         K+    F++L V+G+G +GKVFLV+K S    +  LYAMKVLKKA +    +D   TK ER+IL  IRHPF+V LHYAFQN+  +Y++L +  GG+LF+ L +E    E+   FY+AE++LA+ HLH  GI+YRDLKPEN+LLD+ GH+KLTDFGLSKES+     + T +FCGT+EYMAPE++ R GHG   DWWS G L+F+ML+G  PF Q   ++ET+T IL + ++ P++ SSE   L++ L KRNP  R+G     +E+IK+  FF+   INW D+ +R++ PPFKP+     D SCFDS FT + P  +P  C  A     ++F+GFSYVAP+V     N
Sbjct:   20 DFIRLSERDELSI-QQFIQNGPLKREEDDDIESVEICQSVVNPGVKISMEDFKVLNVIGRGGYGKVFLVQKSSSGHDENKLYAMKVLKKARIIRNEKDTAHTKSERNILEMIRHPFLVKLHYAFQNQSNLYIVLTYCSGGELFTYLEREGTLMENQACFYVAEISLAIGHLHKTGIIYRDLKPENVLLDKKGHVKLTDFGLSKESV-----SLTNTFCGTIEYMAPEILKRGGHGKEVDWWSLGTLLFDMLSGGPPFSQECDKQETITKILHSTIAYPKYFSSEVVRLIQGLLKRNPKERLGCK-NDVEDIKNHEFFKTHDINWSDVYHRRMDPPFKPELKSEMDVSCFDSTFTGQQPIMTPDDCNGAHILP-DLFQGFSYVAPNVASSVLN 403

HSP 2 Score: 116.316 bits (290), Expect = 8.494e-27
Identity = 88/298 (29.53%), Postives = 150/298 (50.34%), Query Frame = 2

Query: 1259 LQHAQNANIEDMKISGWQNIV--GVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVN----YAIKVIDGTK--------------RDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRI 2092
            L+  ++ +IE ++I   Q++V  GVK    D  + +   IG+G +   +     ++G +    YA+KV+   +              R+++E +        HP +VKL   +  Q+ + +++ Y  GGEL T +  +    E +A   +  ++  + +LH   +++RDLKP N+L  KK     ++ + DFG +K+  +   L  T C T  ++APE+LK+ G+ K  D WSLG LLF MLSG  PF+Q E D  E I K +       T    ++ SSE   L+  +L  +P +R+
Sbjct:   41 LKREEDDDIESVEIC--QSVVNPGVKISMED--FKVLNVIGRGGYGKVFLVQKSSSGHDENKLYAMKVLKKARIIRNEKDTAHTKSERNILEMIR-------HPFLVKLHYAFQNQSNLYIVLTYCSGGELFTYLEREGTLMENQACFYVAEISLAIGHLHKTGIIYRDLKPENVLLDKKG----HVKLTDFGLSKESVS---LTNTFCGTIEYMAPEILKRGGHGKEVDWWSLGTLLFDMLSGGPPFSQ-ECDKQETITKILHS-----TIAYPKYFSSEVVRLIQGLLKRNPKERL 314

[Close]

BLAST of Ribosomal protein S6 kinase vs. Planmine SMEST
Match: SMESG000039865.1 (SMESG000039865.1)

HSP 1 Score: 244.202 bits (622), Expect = 6.609e-72
Identity = 142/387 (36.69%), Postives = 224/387 (57.88%), Query Frame = 2

Query:  134 PVTDSFHISNLNEVEVD------EEFSDNAFSQEEEATEVNAVDLVDEKLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKK-ASLKVQDRKRTKMERDILAAIRHP-FIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYXXXXXXXXXXXXXXGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQP---ASATANEIFRGFSYVAPDVL 1261
            PV D  +++++ +++        EE  +   + E      N  D+      +S F  + VLG+GSFGKV L  +    +   LYA+K+LKK   ++  D + T +E+ +LA    P F+V LH  FQ   ++Y ++EF+ GGDL  R+ +E  F E    FY AE+A+ L  LHS GI+YRDLK +NI+LD +GHIK+ DFG+ KE I++D   RTF  CGT +Y+APE++  + +G + DWW++GV+++EML GQ PF G   +E    I +  +S P+ +S E+ ++ + L  ++P  R+G    G  +++   FF+ I+W+ +  R+V PP KPK     D S FD +FT +T + +P       +    E F GFS+V P+ +
Sbjct:  103 PVADDLNVASVADLKAKFEKSILEEKKNQQITNENNYINQNKQDIPR----ASDFNFILVLGKGSFGKVILAERKGTDE---LYAVKILKKDVIIQDDDVECTMIEKRVLALQEKPSFLVQLHSCFQTMDRLYFVMEFVNGGDLMYRIQQEGKFKEPVAVFYTAEIAIGLFFLHSKGIIYRDLKLDNIMLDHEGHIKIADFGMCKEGIFDDKTTRTF--CGTPDYIAPEIIKYQPYGKSVDWWAYGVILYEMLAGQAPFDGEDEEELFNAITEHNVSYPKSMSKESVSICKGLLTKDPKKRLGSNRYGDRDVREHLFFRRIDWEKINARQVQPPNKPKIKDPRDVSNFDQEFTKETAQLTPTDKLFIMNLDQTE-FSGFSFVNPEFI 479

HSP 2 Score: 103.99 bits (258), Expect = 4.078e-23
Identity = 72/255 (28.24%), Postives = 129/255 (50.59%), Query Frame = 2

Query: 1370 IGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVI---EEVEI------LFRFGAHPH-IVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLHCDPAQRITTNQ 2104
            +GKGSF     A  K T   YA+K++   K+DVI   ++VE       +      P  +V+L   +   + +  +ME++ GG+L+  I  +  F E  A      +   + +LH+  +++RDLK  NI+   +     ++ I DFG  K+   ++    T C T +++APE++K Q Y K+ D W+ GV+L+ ML+G+ PF   +    EE+   I + +        + +S E+  +   +L  DP +R+ +N+
Sbjct:  159 LGKGSFGKVILAERKGTDELYAVKIL---KKDVIIQDDDVECTMIEKRVLALQEKPSFLVQLHSCFQTMDRLYFVMEFVNGGDLMYRIQQEGKFKEPVAVFYTAEIAIGLFFLHSKGIIYRDLKLDNIMLDHEG----HIKIADFGMCKEGIFDDKTTRTFCGTPDYIAPEIIKYQPYGKSVDWWAYGVILYEMLAGQAPFDGEDE---EELFNAITEHNVSYP----KSMSKESVSICKGLLTKDPKKRLGSNR 399

The following BLAST results are available for this feature:

BLAST of Ribosomal protein S6 kinase vs. Ensembl Human
BLAST of Ribosomal protein S6 kinase vs. Ensembl Celegans
BLAST of Ribosomal protein S6 kinase vs. Ensembl Fly
BLAST of Ribosomal protein S6 kinase vs. Ensembl Zebrafish
BLAST of Ribosomal protein S6 kinase vs. Ensembl Xenopus
BLAST of Ribosomal protein S6 kinase vs. Ensembl Mouse
BLAST of Ribosomal protein S6 kinase vs. UniProt/SwissProt
BLAST of Ribosomal protein S6 kinase vs. TrEMBL
BLAST of Ribosomal protein S6 kinase vs. Ensembl Cavefish
BLAST of Ribosomal protein S6 kinase vs. Ensembl Sea Lamprey
BLAST of Ribosomal protein S6 kinase vs. Ensembl Yeast
BLAST of Ribosomal protein S6 kinase vs. Ensembl Nematostella
BLAST of Ribosomal protein S6 kinase vs. Ensembl Medaka
BLAST of Ribosomal protein S6 kinase vs. Planmine SMEST

BLAST of Ribosomal protein S6 kinase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
RPS6KA1	0.000e+0	62.12	ribosomal protein S6 kinase A1 [Source:HGNC Symbol...	[more]
RPS6KA1	0.000e+0	62.12	ribosomal protein S6 kinase A1 [Source:HGNC Symbol...	[more]
RPS6KA1	0.000e+0	62.12	ribosomal protein S6 kinase A1 [Source:HGNC Symbol...	[more]
RPS6KA1	0.000e+0	62.12	ribosomal protein S6 kinase A1 [Source:HGNC Symbol...	[more]
RPS6KA1	0.000e+0	62.12	ribosomal protein S6 kinase A1 [Source:HGNC Symbol...	[more]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
rskn-1	0.000e+0	56.58	Putative ribosomal protein S6 kinase alpha-1 [Sou...	[more]
rskn-1	0.000e+0	55.25	Putative ribosomal protein S6 kinase alpha-1 [Sou...	[more]
rskn-1	0.000e+0	55.28	Putative ribosomal protein S6 kinase alpha-1 [Sou...	[more]
rskn-1	0.000e+0	55.05	Putative ribosomal protein S6 kinase alpha-1 [Sou...	[more]
rskn-1	0.000e+0	58.69	Putative ribosomal protein S6 kinase alpha-1 [Sou...	[more]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
S6kII	0.000e+0	54.58	gene:FBgn0262866 transcript:FBtr0333715	[more]
S6kII	0.000e+0	54.58	gene:FBgn0262866 transcript:FBtr0077360	[more]
JIL-1	1.383e-117	36.61	gene:FBgn0020412 transcript:FBtr0076237	[more]
JIL-1	1.383e-117	36.61	gene:FBgn0020412 transcript:FBtr0332707	[more]
JIL-1	1.383e-117	36.61	gene:FBgn0020412 transcript:FBtr0076236	[more]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
rps6ka3a	0.000e+0	60.35	ribosomal protein S6 kinase a, polypeptide 3a [Sou...	[more]
rps6ka3a	0.000e+0	60.24	ribosomal protein S6 kinase a, polypeptide 3a [Sou...	[more]
rps6ka1	0.000e+0	61.97	ribosomal protein S6 kinase a, polypeptide 1 [Sour...	[more]
rps6ka1	0.000e+0	61.97	ribosomal protein S6 kinase a, polypeptide 1 [Sour...	[more]
rps6ka1	0.000e+0	59.51	ribosomal protein S6 kinase a, polypeptide 1 [Sour...	[more]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
rps6ka1	0.000e+0	61.84	ribosomal protein S6 kinase A1 [Source:NCBI gene;A...	[more]
rps6ka1	0.000e+0	62.50	ribosomal protein S6 kinase A1 [Source:NCBI gene;A...	[more]
rps6ka1	0.000e+0	62.50	ribosomal protein S6 kinase A1 [Source:NCBI gene;A...	[more]
rps6ka1	0.000e+0	62.23	ribosomal protein S6 kinase A1 [Source:NCBI gene;A...	[more]
rps6ka1	0.000e+0	62.50	ribosomal protein S6 kinase A1 [Source:NCBI gene;A...	[more]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Rps6ka1	0.000e+0	61.11	ribosomal protein S6 kinase polypeptide 1 [Source:...	[more]
Rps6ka1	0.000e+0	61.99	ribosomal protein S6 kinase polypeptide 1 [Source:...	[more]
Rps6ka1	0.000e+0	60.05	ribosomal protein S6 kinase polypeptide 1 [Source:...	[more]
Rps6ka1	0.000e+0	63.01	ribosomal protein S6 kinase polypeptide 1 [Source:...	[more]
Rps6ka3	0.000e+0	62.83	ribosomal protein S6 kinase polypeptide 3 [Source:...	[more]

BLAST of Ribosomal protein S6 kinase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|P18652\|KS6AA_CHICK	0.000e+0	61.38	Ribosomal protein S6 kinase 2 alpha OS=Gallus gall...	[more]
sp\|Q63531\|KS6A1_RAT	0.000e+0	62.41	Ribosomal protein S6 kinase alpha-1 OS=Rattus norv...	[more]
sp\|Q15418\|KS6A1_HUMAN	0.000e+0	62.12	Ribosomal protein S6 kinase alpha-1 OS=Homo sapien...	[more]
sp\|P10665\|KS6AA_XENLA	0.000e+0	59.54	Ribosomal protein S6 kinase 2 alpha OS=Xenopus lae...	[more]
sp\|P51812\|KS6A3_HUMAN	0.000e+0	59.12	Ribosomal protein S6 kinase alpha-3 OS=Homo sapien...	[more]

BLAST of Ribosomal protein S6 kinase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A2C9JCF0	0.000e+0	63.26	Ribosomal protein S6 kinase OS=Biomphalaria glabra...	[more]
R7TKT4	0.000e+0	61.56	Ribosomal protein S6 kinase OS=Capitella teleta OX...	[more]
A0A210QHD3	0.000e+0	61.10	Ribosomal protein S6 kinase OS=Mizuhopecten yessoe...	[more]
V4B8C1	0.000e+0	61.72	Ribosomal protein S6 kinase OS=Lottia gigantea OX=...	[more]
A0A1S3H586	0.000e+0	60.11	Ribosomal protein S6 kinase OS=Lingula unguis OX=7...	[more]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
rps6ka2	0.000e+0	61.81	ribosomal protein S6 kinase A2 [Source:NCBI gene;A...	[more]
rps6ka1	0.000e+0	59.71	ribosomal protein S6 kinase a, polypeptide 1 [Sour...	[more]
rps6ka1	0.000e+0	59.71	ribosomal protein S6 kinase a, polypeptide 1 [Sour...	[more]
rps6ka1	0.000e+0	59.42	ribosomal protein S6 kinase a, polypeptide 1 [Sour...	[more]
rps6kal	0.000e+0	60.09	ribosomal protein S6 kinase a, like [Source:NCBI g...	[more]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
RPS6KA3	9.072e-111	61.15	ribosomal protein S6 kinase A3 [Source:HGNC Symbol...	[more]
ENSPMAT00000004683.1	8.407e-91	83.24	pep scaffold:Pmarinus_7.0:GL488517:199:5283:1 gene...	[more]
ENSPMAT00000008480.1	9.402e-78	39.36	pep scaffold:Pmarinus_7.0:GL482122:191709:206473:1...	[more]
rps6ka5	1.221e-72	35.76	ribosomal protein S6 kinase, polypeptide 5 [Source...	[more]
ENSPMAT00000006766.1	1.588e-71	38.59	pep scaffold:Pmarinus_7.0:GL478342:9725:27922:-1 g...	[more]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5


Match Name	E-value	Identity	Description
TPK3	3.772e-71	44.52	cAMP-dependent protein kinase catalytic subunit; p...	[more]
YPK1	1.991e-70	43.03	S/T protein kinase; phosphorylates, downregulates ...	[more]
TPK1	3.061e-69	41.38	cAMP-dependent protein kinase catalytic subunit; p...	[more]
YPK2	1.338e-68	42.42	Protein kinase similar to S/T protein kinase Ypk1p...	[more]
SCH9	9.304e-67	42.53	AGC family protein kinase; functional ortholog of ...	[more]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO31895	0.000e+0	62.98	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO39163	4.623e-174	41.97	Ribosomal protein S6 kinase [Source:UniProtKB/TrE...	[more]
EDO41166	1.139e-113	50.53	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO37800	4.860e-73	38.94	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO35585	4.935e-70	40.59	Protein kinase C [Source:UniProtKB/TrEMBL;Acc:A7S...	[more]

BLAST of Ribosomal protein S6 kinase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSORLT00000003187.2	0.000e+0	59.27	ribosomal protein S6 kinase alpha-3 [Source:NCBI g...	[more]
rps6kal	0.000e+0	61.30	highly divergent homeobox [Source:NCBI gene;Acc:10...	[more]
rps6kal	0.000e+0	60.90	highly divergent homeobox [Source:NCBI gene;Acc:10...	[more]
rps6ka1	0.000e+0	58.86	ribosomal protein S6 kinase 2 alpha [Source:NCBI g...	[more]
rps6ka1	0.000e+0	60.17	ribosomal protein S6 kinase 2 alpha [Source:NCBI g...	[more]

BLAST of Ribosomal protein S6 kinase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000059433.1	0.000e+0	99.86	SMESG000059433.1	[more]
SMESG000077749.1	4.660e-163	51.91	SMESG000077749.1	[more]
SMESG000068122.1	1.653e-100	45.36	SMESG000068122.1	[more]
SMESG000004478.1	6.592e-100	45.41	SMESG000004478.1	[more]
SMESG000039865.1	6.609e-72	36.69	SMESG000039865.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30033349 ID=SMED30033349|Name=Ribosomal protein S6 kinase|organism=Schmidtea mediterranea sexual|type=transcript|length=2430bp
CAATTAAATTGACGATCAGTTGAAATAATTTGAGTCAATTTTTCTAATCC
ACTATTGAATTTTAACAATTACTATTTAACAACGTGTAATTATTACAAAT
TGCAACATTAAATCAAAAGTTATGCCACTGGGCCCCGTTACCGATTCATT
TCACATTTCAAATCTTAACGAAGTCGAAGTTGATGAAGAATTTTCCGATA
ATGCATTTTCACAAGAAGAAGAAGCAACAGAAGTAAATGCCGTTGATTTG
GTAGATGAAAAATTGGATTCATCACATTTCGAACTGTTAAGAGTTCTTGG
CCAAGGTTCCTTTGGCAAAGTCTTTTTAGTTCGTAAAGTCAGTGAACCTC
AACAAGGAATACTATATGCTATGAAAGTTTTGAAAAAAGCTTCTTTAAAA
GTTCAAGACAGAAAGAGAACTAAAATGGAAAGGGACATTTTAGCAGCTAT
TCGGCACCCATTTATTGTTACATTACATTATGCTTTTCAAAATGAAGGTA
AAGTCTATCTCATTCTCGAATTCCTAAAAGGAGGAGACTTATTTTCTCGT
TTATCCAAAGAGTTCATGTTCACTGAGGATGATGTCAAATTCTACCTAGC
AGAGTTGGCTCTGGCTCTCGACCACTTGCACAGCTTGGGAATAGTTTATC
GCGATTTGAAACCAGAAAATATTTTACTTGATGAAGATGGGCATATCAAA
TTGACAGATTTTGGATTGTCAAAGGAATCAATTTACAATGACGATGCGAA
TCGGACGTTTTCCTTTTGTGGAACAGTTGAGTATATGGCACCGGAAGTTG
TTAACCGAAAAGGTCATGGGACAGCTGCAGATTGGTGGAGTTTTGGAGTG
TTAATGTTTGAAATGCTTACTGGCCAATTACCATTTCAGGGTTCGTCACG
TAAGGAAACAATGACAATGATTTTAAAAGCTAAATTATCGATGCCACAGT
TTCTGAGTTCAGAGGCGCAAACATTGCTAAGAGTTCTGTTTAAGCGAAAT
CCATCAAACAGAATTGGATTTGGTCCAAAAGGCATTGAAGAAATTAAAAG
CCAACCATTTTTCCAATTAATAAACTGGAAGGATCTGTTAAATAGAAAAG
TAACTCCGCCATTTAAACCCAAAGCTACTTGCTTAGATGACACAAGCTGT
TTTGACTCTCAATTTACTTCTAAAACACCAAAAGAATCCCCCTGTCAGCC
AGCAAGTGCAACTGCCAATGAAATCTTTAGAGGATTCAGTTACGTTGCTC
CTGATGTACTACAACACGCTCAGAATGCAAACATCGAAGATATGAAAATT
TCAGGTTGGCAAAATATTGTTGGGGTAAAATTTCAAAAGGTCGACCATTA
TTACACGTTGAAAGAGGAAATTGGAAAAGGTTCTTTTTCTGTTTGTTATC
GGGCAGTACACAAAACTACAGGTGTAAATTATGCAATCAAGGTTATCGAT
GGAACTAAGAGGGATGTTATAGAAGAAGTGGAAATATTATTTCGATTTGG
GGCACATCCACATATAGTAAAATTAAAAGAAGTTTATGTACAACAAAATA
CAGTTTCACTCATCATGGAATATTTGGAAGGGGGAGAATTATTGACGAAT
ATTTTATCCCAGAAATATTTTTCAGAAAAAGAAGCTAGCAAAATTCTCTA
TGTATTAACGGAAACTGTGCATTATTTGCACACAAATCTGGTTGTCCATC
GAGATCTTAAACCGTCGAATATTTTATATTCCAAAAAGGATACCAATCCT
GAAAATCTTGTGATTTGCGATTTTGGTTTTGCTAAACAACAAAGAGCAGA
AAATGGGTTACTTATGACTCCATGTTATACTGCTAACTTTGTAGCTCCTG
AGGTCCTCAAGAAACAAGGATATGACAAAGCGTCCGACGTGTGGAGTTTA
GGTGTTTTATTGTTCATTATGTTATCAGGGAAAACTCCCTTCACCCAAAA
CGAACATGATCCGCCCGAAGAAATCTTAAAACGAATTGAAAAGAAAAGTT
TCCAGCTAACAGGTGGTCAATGGGAGCACATATCAAGTGAAGCAAAAGAT
TTGTTATTGAAAATGTTGCACTGTGATCCGGCTCAGAGAATCACGACAAA
TCAGATTTTATCTCACAATTGGATAACGTTCAGGTCCAGTCTTCCGTCTA
CTAAGATCGCCATGAATTCGGATCTGAGTTCTGTGAAGGGAGCTGTGAAA
GCCACATACAAAGCTCTTCTAGAAAAGAGTCTTCCTAATTTGGCTCCTGT
TGCAAATTCAACGTTAGCTAAAAGACGTGGTCAGTCGAAACCAAAGAGTT
CCACAGAAATTTAATATAATTATTGAAGATTTCTTCATTAGAAAGAAAAT
ATTATTTGGCATGCGTCTTTTAATTATCTGTAAAATTTTAATTTTCAATT
AAATGCTGTGAATGACTTTTTGTCTATTAA

protein sequence of SMED30033349-orf-1

>SMED30033349-orf-1 ID=SMED30033349-orf-1|Name=SMED30033349-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=731bp
MPLGPVTDSFHISNLNEVEVDEEFSDNAFSQEEEATEVNAVDLVDEKLDS
SHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASLKVQDRKRT
KMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMF
TEDDVKFYLAELALALDHLHSLGIVYRDLKPENILLDEDGHIKLTDFGLS
KESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLT
GQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGF
GPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTS
KTPKESPCQPASATANEIFRGFSYVAPDVLQHAQNANIEDMKISGWQNIV
GVKFQKVDHYYTLKEEIGKGSFSVCYRAVHKTTGVNYAIKVIDGTKRDVI
EEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYF
SEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICD
FGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIM
LSGKTPFTQNEHDPPEEILKRIEKKSFQLTGGQWEHISSEAKDLLLKMLH
CDPAQRITTNQILSHNWITFRSSLPSTKIAMNSDLSSVKGAVKATYKALL
EKSLPNLAPVANSTLAKRRGQSKPKSSTEI*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000020	protonephridia
PLANA:0000034	epidermis
PLANA:0000101	muscle cell
PLANA:0000142	posterior region of the whole animal
PLANA:0003116	parenchymal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR041906	RSK_N
IPR000719	Prot_kinase_dom
IPR000961	AGC-kinase_C
IPR016239	Ribosomal_S6_kinase_II
IPR017892	Pkinase_C
IPR008271	Ser/Thr_kinase_AS
IPR017441	Protein_kinase_ATP_BS
IPR011009	Kinase-like_dom_sf

Vocabulary: **biological process**
Term	Definition
GO:0006468	protein phosphorylation
GO:0035556	intracellular signal transduction
GO:0006915	apoptotic process
GO:0016310	phosphorylation
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:2000491	positive regulation of hepatic stellate cell activation

Vocabulary: **molecular function**
Term	Definition
GO:0005524	ATP binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0000287	magnesium ion binding
GO:0000166	nucleotide binding
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process

Vocabulary: **cellular component**
Term	Definition
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR000961	AGC-kinase, C-terminal	SMART	SM00133	pkinase_C_6	coord: 315..376 e-value: 1.0E-15 score: 68.2
IPR000961	AGC-kinase, C-terminal	PROSITE	PS51285	AGC_KINASE_CTER	coord: 315..384 score: 15.857
IPR000719	Protein kinase domain	SMART	SM00220	serkin_6	coord: 53..314 e-value: 1.6E-100 score: 349.9 coord: 411..668 e-value: 3.3E-94 score: 329.0
IPR000719	Protein kinase domain	PFAM	PF00069	Pkinase	coord: 411..668 e-value: 2.8E-70 score: 236.7 coord: 53..314 e-value: 1.9E-70 score: 237.3
IPR000719	Protein kinase domain	PROSITE	PS50011	PROTEIN_KINASE_DOM	coord: 411..668 score: 47.679
IPR000719	Protein kinase domain	PROSITE	PS50011	PROTEIN_KINASE_DOM	coord: 53..314 score: 54.209
None	No IPR available	GENE3D	G3DSA:1.10.510.10		coord: 448..668 e-value: 1.5E-95 score: 321.3
None	No IPR available	GENE3D	G3DSA:3.30.200.20		coord: 51..351 e-value: 3.3E-121 score: 406.0
None	No IPR available	GENE3D	G3DSA:3.30.200.20		coord: 413..484 e-value: 1.5E-95 score: 321.3
None	No IPR available	GENE3D	G3DSA:1.10.510.10		coord: 139..335 e-value: 3.3E-121 score: 406.0
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 711..730
None	No IPR available	PANTHER	PTHR24351	RIBOSOMAL PROTEIN S6 KINASE	coord: 22..397
None	No IPR available	PANTHER	PTHR24351:SF110	NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE	coord: 416..656
None	No IPR available	PANTHER	PTHR24351	RIBOSOMAL PROTEIN S6 KINASE	coord: 416..656
None	No IPR available	PANTHER	PTHR24351:SF110	NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE	coord: 22..397
None	No IPR available	CDD	cd14091	STKc_RSK_C	coord: 411..699 e-value: 1.07021E-176 score: 504.475
IPR017892	Protein kinase, C-terminal	PFAM	PF00433	Pkinase_C	coord: 339..374 e-value: 1.8E-6 score: 28.6
IPR016239	Ribosomal protein S6 kinase II	PIRSF	PIRSF000606	RPS6_kin_2	coord: 6..730 e-value: 1.6E-299 score: 993.2
IPR017441	Protein kinase, ATP binding site	PROSITE	PS00107	PROTEIN_KINASE_ATP	coord: 59..85
IPR017441	Protein kinase, ATP binding site	PROSITE	PS00107	PROTEIN_KINASE_ATP	coord: 417..440
IPR008271	Serine/threonine-protein kinase, active site	PROSITE	PS00108	PROTEIN_KINASE_ST	coord: 524..536
IPR008271	Serine/threonine-protein kinase, active site	PROSITE	PS00108	PROTEIN_KINASE_ST	coord: 174..186
IPR041906	Ribosomal S6 kinase, N-terminal catalytic domain	CDD	cd05582	STKc_RSK_N	coord: 57..375 e-value: 0.0 score: 640.602
IPR011009	Protein kinase-like domain superfamily	SUPERFAMILY	SSF56112	Protein kinase-like (PK-like)	coord: 389..670
IPR011009	Protein kinase-like domain superfamily	SUPERFAMILY	SSF56112	Protein kinase-like (PK-like)	coord: 51..376