5-hydroxytryptamine receptor
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30033325 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 3
Homology
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Human
Match: DRD2 (dopamine receptor D2 [Source:HGNC Symbol;Acc:HGNC:3023]) HSP 1 Score: 189.889 bits (481), Expect = 9.343e-53 Identity = 158/489 (32.31%), Postives = 225/489 (46.01%), Query Frame = 1
Query: 442 ALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTDINYLHRRTSS--RIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIR-------------YKRKKMKQNHCLSNTDHKSCTDQTKPTENTGQCPCNKRKIDEISYILNCEHCKLESLVIQNQNRKEWFDKHMSLLEFADEGENDSLSIQSNFYATTFANVKFENVDHVANVNCVGENDRNKAETMSNHSQKKINQTTNWSPKLIFYNYKAKLLNFKNDLSFKGSNKSSELQ-FNDDRSQSSLSFKDNKFNAMNSASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNV--AHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKIL 1854
A L +I + GNV V A+ E+ L+ +NYLI+SLAVADL+VA LVMP EV W CD++ DV+ CTASIL+L I+IDRY AV + R SS R+ +MI VW++S IS P F NNA+ CII ++ V+S++ +FY+P ++Y++IYI R R + + R +K N C D K CT K + G P N+R+ V+Q R+ A E E + LS S T ++ + + T+ + S ++ T + SP N AK K E+Q + ++++SL R K+ Q++E+KA + LAI+ G FIICWLPF I ++ H CN P + F WLGYVNS +NP+IYT F+ +FR AF KIL
Sbjct: 38 ATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGL--NNAD------QNECIIANP-AFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGN-CTHPEDMKLCTVIMK---SNGSFPVNRRR------------------VVQEAARR------------AQELEMEMLSSTSPPERTRYSPIP----------------PSHHQLTLPDPSHHGLHSTPD-SPAKPEKNGHAK--------DHPKIAKIFEIQTMPNGKTRTSLKTMS-----------RRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFT----WLGYVNSAVNPIIYTTFNIEFRKAFLKIL 443
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Human
Match: HTR1A (5-hydroxytryptamine receptor 1A [Source:HGNC Symbol;Acc:HGNC:5286]) HSP 1 Score: 186.808 bits (473), Expect = 6.271e-52 Identity = 103/228 (45.18%), Postives = 147/228 (64.47%), Query Frame = 1
Query: 436 ITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTD-INYLHRRTSSRIILMIIGVWLISVIISVPS----RFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHCLSNTDH-KSCTDQTKPTEN 1101
IT+L LG +I ++GN VVAAI LER+L+NV+NYLI SLAV DLMV++LV+P++A+ +V + W LG CDL+ DVL CT+SILHL IA+DRYWA+TD I+Y+++RT R +I WLI +IS+P R R++ + +C I++ YT++S GAFY+P+ M V+Y RI+ AR RIR KK+++ ++T H S Q K + N
Sbjct: 38 ITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPD--------ACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTG--ADTRHGASPAPQPKKSVN 255 HSP 2 Score: 83.1889 bits (204), Expect = 2.770e-16 Identity = 41/87 (47.13%), Postives = 53/87 (60.92%), Query Frame = 1
Query: 1594 ASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKIL 1854
A + K+ RERK +TL II G FI+CWLPF I + FC + L ++ WLGY NS LNPVIY F+ DF+ AF+KI+
Sbjct: 329 AEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKII 415
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Human
Match: HTR1B (5-hydroxytryptamine receptor 1B [Source:HGNC Symbol;Acc:HGNC:5287]) HSP 1 Score: 162.54 bits (410), Expect = 2.055e-43 Identity = 88/191 (46.07%), Postives = 117/191 (61.26%), Query Frame = 1
Query: 445 LFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTD-INYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIIN-ESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRI 1011
+ L I L T + N FV+A + R L +NYLI SLAV DL+V+ILVMPIS + V+ W LG +CD W D+ CTASILHL VIA+DRYWA+TD + Y +RT R +MI VW+ S+ IS+P F E + C++N + + YTV+S +GAFY P + +Y RIY+ ARSRI
Sbjct: 54 MLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEV-----SECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRI 239 HSP 2 Score: 78.9518 bits (193), Expect = 5.011e-15 Identity = 40/86 (46.51%), Postives = 56/86 (65.12%), Query Frame = 1
Query: 1603 RNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPC--GSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKIL 1854
+ K+ RERKA +TL II G FI+CWLPF I ++ C + C A+FD WLGY+NS +NP+IYT+ + DF+ AF K++
Sbjct: 301 KKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICK-DACWFHLAIFDFFT-WLGYLNSLINPIIYTMSNEDFKQAFHKLI 384
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Human
Match: HTR1D (5-hydroxytryptamine receptor 1D [Source:HGNC Symbol;Acc:HGNC:5289]) HSP 1 Score: 162.155 bits (409), Expect = 2.180e-43 Identity = 90/192 (46.88%), Postives = 119/192 (61.98%), Query Frame = 1
Query: 442 ALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTD-INYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIINES-VSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRI 1011
A+ L I L T++ N FV+ I+L R L +NYLI SLA DL+V+ILVMPIS ++ TW G LCD+W D+ CTASILHL VIA+DRYWA+TD + Y RRT+ MI VW IS+ IS+P F E + C++N S +SYT++S GAFY+P + ++Y RIY AR+RI
Sbjct: 42 AVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEM-----SDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRI 228 HSP 2 Score: 90.8929 bits (224), Expect = 5.635e-19 Identity = 49/110 (44.55%), Postives = 66/110 (60.00%), Query Frame = 1
Query: 1531 NDDRSQSSLSFKDNKFNAMNSASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPC--GSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKIL 1854
+ + S L F K +SA R ++ RERKA + L II G FIICWLPF + ++ C + C ALFD WLGY+NS +NP+IYTVF+ +FR AF+KI+
Sbjct: 264 HSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICR-DSCWIHPALFDFFT-WLGYLNSLINPIIYTVFNEEFRQAFQKIV 371
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Human
Match: CHRM3 (cholinergic receptor muscarinic 3 [Source:HGNC Symbol;Acc:HGNC:1952]) HSP 1 Score: 161.384 bits (407), Expect = 1.352e-41 Identity = 136/515 (26.41%), Postives = 248/515 (48.16%), Query Frame = 1
Query: 427 QFYITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVT-DINYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIIN--ESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHCLSNTDHKSCTDQ-TKPTENTGQCP-----------CNKRKIDEISYILNCEHCKL--ESLVIQNQNRKEW--FDKHMSLLEFADEGEND---------SLSIQSNFYATTFANVKFENVDHV-ANVNCVGEND-RNKAETMSNHSQKKINQTTNWSPKLIFYNYKAKLLNFKNDLSFKGSNKSSELQFNDDRSQSS--LSFKDNKFNAMNSASIRNKVEQK------RERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKILL 1857
Q A G + L TIIGN+ V+ + + + LK V+NY +LSLA ADL++ ++ M + + + W LG CDLW D ++ AS+++L+VI+ DRY+++T + Y +RT+ R +MI W+IS ++ P+ + R + G C I + T + + AFY+P+ M+++Y RIY + K+ K+ L + ++ T+ PT ++ C N+RK + + K E + + + W D SL A E D S+ ++ ++T + K + D++ +G D KA+ + +QK ++ ++ PK ++ + ++ + + K+S++ + +S ++ LSFK+ + R+++ ++ +E+KAA+TL+ I FII W P+ I + + FC++ C F +L WL Y+NS +NPV Y + + FRT F+ +LL
Sbjct: 67 QVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGK--RTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIY-------KETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKL--QAQKSVDDGGSF-PK----SFSKLPIQLESAVD---TAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDS--CIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLL 560
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Celegans
Match: dop-4 (Dopamine receptor 4 [Source:UniProtKB/Swiss-Prot;Acc:Q18775]) HSP 1 Score: 187.578 bits (475), Expect = 1.023e-51 Identity = 145/492 (29.47%), Postives = 235/492 (47.76%), Query Frame = 1
Query: 436 ITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSS-TWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTD-INYLHRRTSSRIILMIIGVWLISVIISVP-------SRFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHCLSNTDHKSCTDQTKPTENTGQCPCNKRKIDEISYILNCEHCKLESLVIQNQNRKEWFDKHMSLLEFADEGENDSLSIQSNFYATTFANVKFENVDHVANVNCVGENDRNKAETMSNHSQKKINQTTNWSPKLIFYNYKAKLLNFKNDLSFKGSNKSSELQFNDDRSQSSLSFKDNKFNAMNSASIRNKV---EQKR-------ERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKIL 1854
+ A+ L +I L T+ GN VV A+ ++ L+N + YLI+SLA+ADL+V ++VMP++++ E+++ TW G+ +CD++ D+L+ TASI +L VI++DRY A D I Y + + RI++ I+ VW++S I+S P S H + + ++ C+ +S Y FS+L +FY+P+ + Y ++YI A + R +K KS T E IL+ E ++ + F ++ S S F+A + + V+C NDR + + Q + T I ++ NF+ GSN SS L D + SLS +++ + S R K+ E+ R E++AARTL+I+ G FI+CW PF + AFC + + W G++NS LNP+IY+ FS DFR AF++IL
Sbjct: 44 LLAIALFSICLLTVAGNCLVVIAVCTKKYLRNPTGYLIISLAIADLIVGVIVMPMNSLFEIANHTWLFGLMMCDVFHAMDILASTASIWNLCVISLDRYMAGQDPIGYRDKVSKRRILMAILSVWVLSAILSFPGIIWWRTSSPHLYEDQSQ---------CLFTDSKMYVSFSSLVSFYIPLFLILFAYGKVYIIATRHSKGMRMGIKTVSIKKRNGKKSNT--------------------ETESILSSE------------------NEPTLRIHFGRGKQSSSSLRNSRFHARESTRLLLK------QVSCKSLNDRGEHNNNNTVRQPLLRGTEGCHSDSI---SRSSQRNFRGRNVTIGSNCSSTLLQVDQPDRMSLS-SNSQMVMTSPLSTRRKLNVREKSRQMMRYVHEQRAARTLSIVVGAFILCWTPFFVFTPLTAFCESCFSNKETIFTFVTWAGHLNSMLNPLIYSRFSRDFRRAFKQIL 478
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Celegans
Match: tyra-3 (TYRAmine receptor [Source:UniProtKB/TrEMBL;Acc:Q2L6V9]) HSP 1 Score: 187.193 bits (474), Expect = 3.012e-51 Identity = 147/483 (30.43%), Postives = 235/483 (48.65%), Query Frame = 1
Query: 442 ALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEV-SSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVT-DINYLHRRTSSRIILMIIGVWLISVIISVPS-------RFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHCLSNTDHKSCTDQTKPTENTGQCPCNKRKIDEISYILNCEHCKLESLVIQNQNRKEWFDKHMSLLEFADEGENDSLSIQSNFYATTFANVKFENVDHVANVNCVGENDRNKAETMSNHSQKKINQTTNWSPKLIFYNYKAKLLNFKNDLSFKGSNKSSELQFNDDRSQSSLSFKDNKFNAMNSASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALF---DSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKIL 1854
ALFL +IL TI GN+ VV ++V+ + ++ +N L+ SLA ADL+V ++VMP+S + + + W LG LC +W DVL CTASIL+L VI++DRY+A+T + Y R+ ++ VW IS ++ P F + NN + C + SV+Y ++S LG+FYLP+ M +Y +I+ A R R+ + LSN K+ + T P ++ ++ ++++ NC ++ NR E K S F DS + A T N+ V + + N + + +N E HS I + + + K + LS + ++ LQ N+ ++ ++ N S + K+ RERKA +T+ I+ FIICW+PF I + F + S ++ LWLGY NS LNP+IYT+++ DFR FR +L
Sbjct: 75 ALFLVMLILLTIFGNILVVLSVVVYKRMRTFTNILLTSLATADLLVGLIVMPMSLLDLLHNHRWPLGRFLCRMWATSDVLLCTASILNLCVISLDRYFAITSPLKYPRTRSRKMAAGLLTAVWAISFVVCSPPWVIPSWNLFIDNNNNTGSSE---DFKCAYSPSVAYRIYSALGSFYLPLLVMLFVYFKIFRVASEREALMRQSVGTCR-LSNRLTKTQQKNQRNNLRTASAPHSRTRV-QVNH--NCGRVNYSVRPVEYANRVENSLKP-SHERFDSTDCEDSPPNGDSLEAGTTCNISMSLVTN-SPPNGLQKEAKNSMER-ECHSLADIVNSADTPVR------KNTEVGVAPSLSKRARQCNARLQPNNLLQKAHEHYQINGPGKAVRGS-KEKMVYMRERKALKTIGIVVLGFIICWMPFFIMYLVEVFISDPVAESPIYRITSEFFLWLGYSNSVLNPIIYTMYNGDFRRCFRDLL 540
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Celegans
Match: tyra-3 (TYRAmine receptor [Source:UniProtKB/TrEMBL;Acc:Q2L6V9]) HSP 1 Score: 186.808 bits (473), Expect = 6.686e-51 Identity = 147/483 (30.43%), Postives = 235/483 (48.65%), Query Frame = 1
Query: 442 ALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEV-SSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTD-INYLHRRTSSRIILMIIGVWLISVIISVPS-------RFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHCLSNTDHKSCTDQTKPTENTGQCPCNKRKIDEISYILNCEHCKLESLVIQNQNRKEWFDKHMSLLEFADEGENDSLSIQSNFYATTFANVKFENVDHVANVNCVGENDRNKAETMSNHSQKKINQTTNWSPKLIFYNYKAKLLNFKNDLSFKGSNKSSELQFNDDRSQSSLSFKDNKFNAMNSASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALF---DSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKIL 1854
ALFL +IL TI GN+ VV ++V+ + ++ +N L+ SLA ADL+V ++VMP+S + + + W LG LC +W DVL CTASIL+L VI++DRY+A+T + Y R+ ++ VW IS ++ P F + NN + C + SV+Y ++S LG+FYLP+ M +Y +I+ A R R+ + LSN K+ + T P ++ ++ ++++ NC ++ NR E K S F DS + A T N+ V + + N + + +N E HS I + + + K + LS + ++ LQ N+ ++ ++ N S + K+ RERKA +T+ I+ FIICW+PF I + F + S ++ LWLGY NS LNP+IYT+++ DFR FR +L
Sbjct: 103 ALFLVMLILLTIFGNILVVLSVVVYKRMRTFTNILLTSLATADLLVGLIVMPMSLLDLLHNHRWPLGRFLCRMWATSDVLLCTASILNLCVISLDRYFAITSPLKYPRTRSRKMAAGLLTAVWAISFVVCSPPWVIPSWNLFIDNNNNTGSSE---DFKCAYSPSVAYRIYSALGSFYLPLLVMLFVYFKIFRVASEREALMRQSVGTCR-LSNRLTKTQQKNQRNNLRTASAPHSRTRV-QVNH--NCGRVNYSVRPVEYANRVENSLKP-SHERFDSTDCEDSPPNGDSLEAGTTCNISMSLVTN-SPPNGLQKEAKNSMER-ECHSLADIVNSADTPVR------KNTEVGVAPSLSKRARQCNARLQPNNLLQKAHEHYQINGPGKAVRGS-KEKMVYMRERKALKTIGIVVLGFIICWMPFFIMYLVEVFISDPVAESPIYRITSEFFLWLGYSNSVLNPIIYTMYNGDFRRCFRDLL 568
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Celegans
Match: tyra-3 (TYRAmine receptor [Source:UniProtKB/TrEMBL;Acc:Q2L6V9]) HSP 1 Score: 181.415 bits (459), Expect = 7.950e-50 Identity = 143/477 (29.98%), Postives = 231/477 (48.43%), Query Frame = 1
Query: 460 IILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEV-SSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTD-INYLHRRTSSRIILMIIGVWLISVIISVPS-------RFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHCLSNTDHKSCTDQTKPTENTGQCPCNKRKIDEISYILNCEHCKLESLVIQNQNRKEWFDKHMSLLEFADEGENDSLSIQSNFYATTFANVKFENVDHVANVNCVGENDRNKAETMSNHSQKKINQTTNWSPKLIFYNYKAKLLNFKNDLSFKGSNKSSELQFNDDRSQSSLSFKDNKFNAMNSASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALF---DSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKIL 1854
+IL TI GN+ VV ++V+ + ++ +N L+ SLA ADL+V ++VMP+S + + + W LG LC +W DVL CTASIL+L VI++DRY+A+T + Y R+ ++ VW IS ++ P F + NN + C + SV+Y ++S LG+FYLP+ M +Y +I+ A R R+ + LSN K+ + T P ++ ++ ++++ NC ++ NR E K S F DS + A T N+ V + + N + + +N E HS I + + + K + LS + ++ LQ N+ ++ ++ N S + K+ RERKA +T+ I+ FIICW+PF I + F + S ++ LWLGY NS LNP+IYT+++ DFR FR +L
Sbjct: 2 LILLTIFGNILVVLSVVVYKRMRTFTNILLTSLATADLLVGLIVMPMSLLDLLHNHRWPLGRFLCRMWATSDVLLCTASILNLCVISLDRYFAITSPLKYPRTRSRKMAAGLLTAVWAISFVVCSPPWVIPSWNLFIDNNNNTGSSE---DFKCAYSPSVAYRIYSALGSFYLPLLVMLFVYFKIFRVASEREALMRQSVGTCR-LSNRLTKTQQKNQRNNLRTASAPHSRTRV-QVNH--NCGRVNYSVRPVEYANRVENSLKP-SHERFDSTDCEDSPPNGDSLEAGTTCNISMSLVTN-SPPNGLQKEAKNSMER-ECHSLADIVNSADTPVR------KNTEVGVAPSLSKRARQCNARLQPNNLLQKAHEHYQINGPGKAVRGS-KEKMVYMRERKALKTIGIVVLGFIICWMPFFIMYLVEVFISDPVAESPIYRITSEFFLWLGYSNSVLNPIIYTMYNGDFRRCFRDLL 461
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Celegans
Match: ser-4 (SERotonin/octopamine receptor family; Serotonin receptor [Source:UniProtKB/TrEMBL;Acc:G5EGH0]) HSP 1 Score: 167.162 bits (422), Expect = 4.252e-45 Identity = 89/203 (43.84%), Postives = 130/203 (64.04%), Query Frame = 1
Query: 424 IQFYITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNY-LILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTDINYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKK 1029
+Q I A L +IL IGN+FV+ AI++ER L+ Y LI SLAVADL+V ++V P+ A V+ TW LG+ +CD W DVL CTASILHLV IA+DRYW++TDI Y+ RT RI LM+ +W S++IS+ + F ++ RV+ + C+I++ +SY VFS AFY+P+ + +Y +I A+ R + +R +
Sbjct: 49 VQTVILASVLLVLILSCFIGNLFVILAIIMERDLRGRPQYYLIFSLAVADLLVGMIVTPLGAWFTVTGTWNLGVVVCDFWISVDVLVCTASILHLVAIALDRYWSITDICYVQNRTPKRITLMLAVIWFTSLLISL-APFAGWKDEGFSDRVLKSHVCLISQQISYQVFSTATAFYIPLIAIICVYWKIMRAAKKRFKRERDR 250 HSP 2 Score: 96.2857 bits (238), Expect = 6.772e-21 Identity = 47/90 (52.22%), Postives = 60/90 (66.67%), Query Frame = 1
Query: 1615 EQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKILLGHYHTRRCL 1884
E KRERKA RTLAIITG F+ CW PF + ++ C + S + + + LWLGY+NS LNP+IYTVFS DFR AF++I+ R CL
Sbjct: 359 EMKRERKAWRTLAIITGTFVACWTPFFLVSIYRPICGCQ--ISPVLEQVTLWLGYLNSALNPIIYTVFSQDFRAAFKRII-----KRMCL 441
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Fly
Match: Oct-TyrR (gene:FBgn0004514 transcript:FBtr0078479) HSP 1 Score: 231.106 bits (588), Expect = 7.118e-67 Identity = 154/497 (30.99%), Postives = 253/497 (50.91%), Query Frame = 1
Query: 436 ITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTD-INYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGS-CIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNH-CLSNTDHKSCTDQTK-PTENTGQCPCNKRKIDEISYILNCEHCKLESLVIQNQNRKEWFDKHMSLLEFADEGENDSLSIQSNFYATTFANVKFENVDHVANVNCVGENDRNKAETMSNHSQKKINQTTNWSPKLIFYNYKAKLLNFKNDLSFK-GSNKSSELQFNDDRSQSSLSFK------DNKFNAMNSASIRNK-------VEQK------RERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKIL 1854
+TAL L II+ TIIGN+ V+ ++ + L+ V N+ I+SLAVADL VA+LV+P + + W GI LC LW DVL CT+SIL+L IA+DRYWA+TD INY +RT R++L+I GVWL+S++IS P + +W + + C + Y ++S+LG+F++P+A M+++Y+ I++ R R+R + + K N L +T+ + + + N+G +K ++ + + + +IQN + H +S Q + + + + D + + G + T H ++++ + ++S + GS+ +Q ++ S K A++ ++ K +E+K +ER+AARTL II G F+ICWLPF + V FC T C + F + WLGY+NSGLNPVIYT+F+ D+R AF+++L
Sbjct: 111 LTALVLSVIIVLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVAYSILGRWEFGIHLCKLWLTCDVLCCTSSILNLCAIALDRYWAITDPINYAQKRTVGRVLLLISGVWLLSLLISSPPLIGWN----DWPDEFTSATPCELTSQRGYVIYSSLGSFFIPLAIMTIVYIEIFVATRRRLRERARANKLNTIALKSTELEPMANSSPVAASNSG----SKSRLLASWLCCGRDRAQFATPMIQNDQESISSETHQPQDSSKAGPHGNSDPQQQHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQSSSTCEPHGEQQLLPAGGDGGSCQPGGGHSGGGKSDAEISTESGSDPKGCIQVCVTQADEQTSLKLTPPQSSTGVAAVSVTPLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIMGVFVICWLPFFLMYVILPFCQTC-CPTNKFKNFITWLGYINSGLNPVIYTIFNLDYRRAFKRLL 598
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Fly
Match: Oct-TyrR (gene:FBgn0004514 transcript:FBtr0301930) HSP 1 Score: 231.106 bits (588), Expect = 7.118e-67 Identity = 154/497 (30.99%), Postives = 253/497 (50.91%), Query Frame = 1
Query: 436 ITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTD-INYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGS-CIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNH-CLSNTDHKSCTDQTK-PTENTGQCPCNKRKIDEISYILNCEHCKLESLVIQNQNRKEWFDKHMSLLEFADEGENDSLSIQSNFYATTFANVKFENVDHVANVNCVGENDRNKAETMSNHSQKKINQTTNWSPKLIFYNYKAKLLNFKNDLSFK-GSNKSSELQFNDDRSQSSLSFK------DNKFNAMNSASIRNK-------VEQK------RERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKIL 1854
+TAL L II+ TIIGN+ V+ ++ + L+ V N+ I+SLAVADL VA+LV+P + + W GI LC LW DVL CT+SIL+L IA+DRYWA+TD INY +RT R++L+I GVWL+S++IS P + +W + + C + Y ++S+LG+F++P+A M+++Y+ I++ R R+R + + K N L +T+ + + + N+G +K ++ + + + +IQN + H +S Q + + + + D + + G + T H ++++ + ++S + GS+ +Q ++ S K A++ ++ K +E+K +ER+AARTL II G F+ICWLPF + V FC T C + F + WLGY+NSGLNPVIYT+F+ D+R AF+++L
Sbjct: 111 LTALVLSVIIVLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVAYSILGRWEFGIHLCKLWLTCDVLCCTSSILNLCAIALDRYWAITDPINYAQKRTVGRVLLLISGVWLLSLLISSPPLIGWN----DWPDEFTSATPCELTSQRGYVIYSSLGSFFIPLAIMTIVYIEIFVATRRRLRERARANKLNTIALKSTELEPMANSSPVAASNSG----SKSRLLASWLCCGRDRAQFATPMIQNDQESISSETHQPQDSSKAGPHGNSDPQQQHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQSSSTCEPHGEQQLLPAGGDGGSCQPGGGHSGGGKSDAEISTESGSDPKGCIQVCVTQADEQTSLKLTPPQSSTGVAAVSVTPLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIMGVFVICWLPFFLMYVILPFCQTC-CPTNKFKNFITWLGYINSGLNPVIYTIFNLDYRRAFKRLL 598
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Fly
Match: 5-HT1A (gene:FBgn0004168 transcript:FBtr0086577) HSP 1 Score: 214.927 bits (546), Expect = 2.215e-59 Identity = 107/210 (50.95%), Postives = 150/210 (71.43%), Query Frame = 1
Query: 376 NVTESQIAR--FSPRLSWIQFYITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTDINYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFA 999
NVT S++A F+ ++ +T++ LG +IL TIIGNVFV+AAI+LER L+NV+NYL+ SLAVADL VA LVMP+ A+ E+S W LG ELCD+WT DVL CTASILHLV IA+DRYWAVT+I+Y+H RTS+R+ +MI VW +VI+S+ +F + ++L+ I C++++ VSY VF+ FY+P+ + +Y +IY A
Sbjct: 209 NVTTSKVAEDDFT---QLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTNIDYIHSRTSNRVFMMIFCVWTAAVIVSLAPQF--GWKDPDYLQRIEQQKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIYQTA 413 HSP 2 Score: 105.145 bits (261), Expect = 4.868e-23 Identity = 52/98 (53.06%), Postives = 65/98 (66.33%), Query Frame = 1
Query: 1603 RNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCG-SALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKILLG-----HYHTRR 1878
+ +E KRERKAA+TLAIITG F++CWLPF + + C C S SL LWLGY NS LNPVIYT+FSP+FR AF++IL G HY + +
Sbjct: 738 KETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAA--CQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRILFGGHRPVHYRSGK 833
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Fly
Match: 5-HT1A (gene:FBgn0004168 transcript:FBtr0474126) HSP 1 Score: 214.542 bits (545), Expect = 2.757e-59 Identity = 107/210 (50.95%), Postives = 150/210 (71.43%), Query Frame = 1
Query: 376 NVTESQIAR--FSPRLSWIQFYITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTDINYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFA 999
NVT S++A F+ ++ +T++ LG +IL TIIGNVFV+AAI+LER L+NV+NYL+ SLAVADL VA LVMP+ A+ E+S W LG ELCD+WT DVL CTASILHLV IA+DRYWAVT+I+Y+H RTS+R+ +MI VW +VI+S+ +F + ++L+ I C++++ VSY VF+ FY+P+ + +Y +IY A
Sbjct: 209 NVTTSKVAEDDFT---QLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTNIDYIHSRTSNRVFMMIFCVWTAAVIVSLAPQF--GWKDPDYLQRIEQQKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIYQTA 413 HSP 2 Score: 105.145 bits (261), Expect = 5.827e-23 Identity = 55/107 (51.40%), Postives = 69/107 (64.49%), Query Frame = 1
Query: 1579 NAMNSASIRNK-VEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCG-SALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKILLG-----HYHTRR 1878
N M + R + +E KRERKAA+TLAIITG F++CWLPF + + C C S SL LWLGY NS LNPVIYT+FSP+FR AF++IL G HY + +
Sbjct: 729 NPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAA--CQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRILFGGHRPVHYRSGK 833
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Fly
Match: 5-HT1B (gene:FBgn0263116 transcript:FBtr0330055) HSP 1 Score: 206.068 bits (523), Expect = 6.160e-58 Identity = 106/222 (47.75%), Postives = 150/222 (67.57%), Query Frame = 1
Query: 424 IQFYITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTDINYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHCLSNTDHKSCTDQTK 1089
++ A+ LG +IL TIIGNVFV+AAI+LER L+NV+NYL+ SLAVADL VA LVMP+ A+ E+S+ W LG ELCD+WT DVL CTASILHLV IA DRYW VT+I+Y + RT R+ LMI VW ++I+S+ +F + ++++ I C++++ V Y +F+ FY+P+ + +Y +IYI AR RI+ +R + N L+ TD S + K
Sbjct: 88 VKMIAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNGWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTNIDYNNLRTPRRVFLMIFCVWFAALIVSLAPQFGW--KDPDYMKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKRIQ-RRAQKSFNVTLTETDCDSAVRELK 306 HSP 2 Score: 104.76 bits (260), Expect = 3.178e-23 Identity = 51/89 (57.30%), Postives = 64/89 (71.91%), Query Frame = 1
Query: 1594 ASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKILLG 1860
A R +E KRERKAA+TLAIITG F+ICWLPF + + + C +A+ SL LWLGY NS LNPVIYT+F+P+FR AF++IL G
Sbjct: 463 AKRRQLLEAKRERKAAQTLAIITGAFVICWLPFFVMALTMSLCKECEIHTAV-ASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRILFG 550
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Zebrafish
Match: drd2a (dopamine receptor D2a [Source:ZFIN;Acc:ZDB-GENE-021119-2]) HSP 1 Score: 194.512 bits (493), Expect = 1.105e-54 Identity = 150/492 (30.49%), Postives = 237/492 (48.17%), Query Frame = 1
Query: 427 QFYITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTDINYLHRRTSS--RIILMIIGVWLISVIISVPSRFHTHR--NNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHCLSNTDH----KSCTDQ------TKPTENTGQCPCNKRKIDEISYIL-NCEHCKLESLVIQNQNRKEWFDKHMSLLEFADEGENDSLSIQSNFYATTFANVKFENVDHVANVNCVGENDRNKAETMSNHSQKKINQTTNWSPKLIFYNYKAKLLNFKNDLSFKGSNKSSELQFND-DRSQSSLSFKDNKFNAMNSASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKIL 1854
Q+ A+ L +I + GNV V A+ E+ L+ +NYLI+SLAVADL+VA LVMP EV W CD++ DV+ CTASIL+L I+IDRY AV + R SS R+ +MI VW++S IS P F + + + L VI N ++ V+S++ +FY+P ++Y++IY+ R R KR K+ +++ D K CT T +++G CP N + + I ++ N + +++ + +N +R+ D+ + + +S + SN T + E A V + +RN N S K+ E+Q + ++Q+S+ + + K+ Q++E+KA + LAI+ G FIICWLPF I ++ + +C P L+ + WLGYVNS +NP+IYT F+ +FR AF KIL
Sbjct: 31 QYNYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSTIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISVVWILSFAISCPLLFGLNNTVTHDDALCVIANP--------AFVVYSSIVSFYVPFIITLLVYVQIYVVLRK--RRKRVNTKRTCPVTDMDMSSTIKKCTHPDDVKLCTVIVKSSGNCPVNNKNVIFIKEVVNNGDDIQMDEITNRNPSRQRKQDQ-------SGGSQQNSRLVNSNLRETDISPPSPE-----AGV----KPERN-----------------------------------GNTSSITKGAKAFEIQVSPTGKTQTSVKTLNKR-----------KISQQKEKKATQMLAIVLGVFIICWLPFFITHIVNTYCQVPP---ELYTAFT-WLGYVNSAVNPIIYTTFNIEFRKAFIKIL 446
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Zebrafish
Match: drd2a (dopamine receptor D2a [Source:ZFIN;Acc:ZDB-GENE-021119-2]) HSP 1 Score: 194.512 bits (493), Expect = 1.105e-54 Identity = 150/492 (30.49%), Postives = 237/492 (48.17%), Query Frame = 1
Query: 427 QFYITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTDINYLHRRTSS--RIILMIIGVWLISVIISVPSRFHTHR--NNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHCLSNTDH----KSCTDQ------TKPTENTGQCPCNKRKIDEISYIL-NCEHCKLESLVIQNQNRKEWFDKHMSLLEFADEGENDSLSIQSNFYATTFANVKFENVDHVANVNCVGENDRNKAETMSNHSQKKINQTTNWSPKLIFYNYKAKLLNFKNDLSFKGSNKSSELQFND-DRSQSSLSFKDNKFNAMNSASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKIL 1854
Q+ A+ L +I + GNV V A+ E+ L+ +NYLI+SLAVADL+VA LVMP EV W CD++ DV+ CTASIL+L I+IDRY AV + R SS R+ +MI VW++S IS P F + + + L VI N ++ V+S++ +FY+P ++Y++IY+ R R KR K+ +++ D K CT T +++G CP N + + I ++ N + +++ + +N +R+ D+ + + +S + SN T + E A V + +RN N S K+ E+Q + ++Q+S+ + + K+ Q++E+KA + LAI+ G FIICWLPF I ++ + +C P L+ + WLGYVNS +NP+IYT F+ +FR AF KIL
Sbjct: 31 QYNYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSTIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISVVWILSFAISCPLLFGLNNTVTHDDALCVIANP--------AFVVYSSIVSFYVPFIITLLVYVQIYVVLRK--RRKRVNTKRTCPVTDMDMSSTIKKCTHPDDVKLCTVIVKSSGNCPVNNKNVIFIKEVVNNGDDIQMDEITNRNPSRQRKQDQ-------SGGSQQNSRLVNSNLRETDISPPSPE-----AGV----KPERN-----------------------------------GNTSSITKGAKAFEIQVSPTGKTQTSVKTLNKR-----------KISQQKEKKATQMLAIVLGVFIICWLPFFITHIVNTYCQVPP---ELYTAFT-WLGYVNSAVNPIIYTTFNIEFRKAFIKIL 446
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Zebrafish
Match: htr1aa (5-hydroxytryptamine (serotonin) receptor 1A a [Source:ZFIN;Acc:ZDB-GENE-071203-1]) HSP 1 Score: 187.963 bits (476), Expect = 9.263e-53 Identity = 107/241 (44.40%), Postives = 153/241 (63.49%), Query Frame = 1
Query: 370 YENVTESQI----ARFSPRLSWIQFYITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTD-INYLHRRTSSRIILMIIGVWLISVIISVPS----RFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQ----NHCLS 1053
Y N TESQ A ++ I +LFL A+IL+ I+GN V+AAI LER+L+NV+NYLI SLAV DLMV++LV+P++A+ +V + W LG E+CD++ DVL CT+SILHL IA+DRYWA+TD I+Y+++RT R ++I WLI IS+P R R + + +C I++ YT++S GAFY+P+ M V+Y RI+ AR RIR KK ++ + CL+
Sbjct: 4 YNNTTESQDWSGNATSVSEVALSYQIIGSLFLAALILFAILGNACVIAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQEMCDIFISLDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAILISLTWLIGFSISIPPMLGWRKPEDRADPD--------ACTISQDHGYTIYSTFGAFYIPLILMLVLYGRIFRAARFRIRKTVKKTEKAKIADKCLA 236 HSP 2 Score: 78.1814 bits (191), Expect = 6.751e-15 Identity = 42/85 (49.41%), Postives = 51/85 (60.00%), Query Frame = 1
Query: 1603 RNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPC-GSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKIL 1854
+ KV RERK +TL II G FI CWLPF I + FC + C ++ WLGY NS LNPVIY F+ DF+ AF+KIL
Sbjct: 309 KRKVALARERKTVKTLGIIMGTFIFCWLPFFIVALVLPFC--QDCFMPEWLGAVINWLGYSNSLLNPVIYAYFNKDFQNAFKKIL 391
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Zebrafish
Match: drd2b (dopamine receptor D2b [Source:ZFIN;Acc:ZDB-GENE-030910-2]) HSP 1 Score: 186.422 bits (472), Expect = 9.579e-52 Identity = 144/483 (29.81%), Postives = 224/483 (46.38%), Query Frame = 1
Query: 427 QFYITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTDINYLHRRTSS--RIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHCLSNTDHKSCTDQTKPTENTGQCPCNKRKIDEISYILNCEHCKLESLVIQNQNRKEWFDKHMSLL-EFADEGENDSLSIQSNFYATTFANVKFEN---VDHVANVNCVGENDRNKAETMSNHSQKKINQTTNWSPKLIFYNYKAKLLNFKNDLSFKGSNKSSELQ-FNDDRSQSSLSFKDNKFNAMNSASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKIL 1854
Q+ A+ L +I + GNV V A+ E+ L+ +NYLI+SLAVADL+VA LVMP EV W CD++ DV+ CTASIL+L I+IDRY AV + R SS R+ +MI VW++S IS P F + +GS + ++ V+S++ +FY+P ++Y++IY+ R R RK++ TD D P + P E KL +++I+ +K L+ E +G + + + + + K + VD +A + AE SN +K + SPK K E Q + +++++++ +K K+ Q +E+KA + LAI+ G FIICWLPF I ++ C + ++++ WLGYVNS +NP+IYT F+ +FR AF KIL
Sbjct: 31 QYNYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSKIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISVVWVLSFAISCPLLFGLNNTATR------DGSVCEIANPAFVVYSSIMSFYVPFIITLLVYVQIYVVLRKR----RKRVNTKRSCQKTD----ADAQPPLKEKCTHP---------------EDVKLCTVIIKTNGGVPAKNKKAQLIKEVLHQGGDVGMEMVAG--TSPPEKKKLASSLVVDLLATPPSPNHGSPSHAEYQSNGDEKNGHAKDVQSPK---------------------ETKPVETQALPNGKTRTTVTKTMSK----------RKMSQHKEKKATQMLAIVLGVFIICWLPFFITHILKTHCTSCVVPLEMYNAFT-WLGYVNSAVNPIIYTTFNVEFRKAFIKIL 450
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Zebrafish
Match: drd2b (dopamine receptor D2b [Source:ZFIN;Acc:ZDB-GENE-030910-2]) HSP 1 Score: 186.422 bits (472), Expect = 9.579e-52 Identity = 144/483 (29.81%), Postives = 224/483 (46.38%), Query Frame = 1
Query: 427 QFYITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTDINYLHRRTSS--RIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHCLSNTDHKSCTDQTKPTENTGQCPCNKRKIDEISYILNCEHCKLESLVIQNQNRKEWFDKHMSLL-EFADEGENDSLSIQSNFYATTFANVKFEN---VDHVANVNCVGENDRNKAETMSNHSQKKINQTTNWSPKLIFYNYKAKLLNFKNDLSFKGSNKSSELQ-FNDDRSQSSLSFKDNKFNAMNSASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKIL 1854
Q+ A+ L +I + GNV V A+ E+ L+ +NYLI+SLAVADL+VA LVMP EV W CD++ DV+ CTASIL+L I+IDRY AV + R SS R+ +MI VW++S IS P F + +GS + ++ V+S++ +FY+P ++Y++IY+ R R RK++ TD D P + P E KL +++I+ +K L+ E +G + + + + + K + VD +A + AE SN +K + SPK K E Q + +++++++ +K K+ Q +E+KA + LAI+ G FIICWLPF I ++ C + ++++ WLGYVNS +NP+IYT F+ +FR AF KIL
Sbjct: 31 QYNYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSKIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISVVWVLSFAISCPLLFGLNNTATR------DGSVCEIANPAFVVYSSIMSFYVPFIITLLVYVQIYVVLRKR----RKRVNTKRSCQKTD----ADAQPPLKEKCTHP---------------EDVKLCTVIIKTNGGVPAKNKKAQLIKEVLHQGGDVGMEMVAG--TSPPEKKKLASSLVVDLLATPPSPNHGSPSHAEYQSNGDEKNGHAKDVQSPK---------------------ETKPVETQALPNGKTRTTVTKTMSK----------RKMSQHKEKKATQMLAIVLGVFIICWLPFFITHILKTHCTSCVVPLEMYNAFT-WLGYVNSAVNPIIYTTFNVEFRKAFIKIL 450
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Xenopus
Match: DRD2 (dopamine receptor D2 [Source:NCBI gene;Acc:100493063]) HSP 1 Score: 185.652 bits (470), Expect = 2.101e-51 Identity = 150/480 (31.25%), Postives = 224/480 (46.67%), Query Frame = 1
Query: 442 ALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTDINYLHRRTSS--RIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQN-HCLSNTDHKSCTDQTKPTENTGQCPCNKRKIDEISYILNCEHCKLESLVIQNQNRKEWFDKHMSLLEFADEGENDSLSIQSNFYATTFANVKFENVDHVANVNCVGENDRNKAETMSNHSQKKINQTTNWS-----PKLIFYNYKAKLLNFKNDLSFKGSNKSSELQ-FNDDRSQSSLSFKDNKFNAMNSASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKIL 1854
A+ L +I + GNV V A+ E+ L+ +NYLI+SLAVADL+VA LVMP EV W CD++ DV+ CTASIL+L I+IDRY AV + R SS R+ +MI VW++S IS P F L + CII+ ++ ++S++ +FY+P ++Y++IYI R R KR K+N H + HK D+ E+ C V N DK + E + E+ + + S+ E ++K+ + NH Q + T+N P + YKA+ D + K E+Q + ++++S+ + K+ Q +E+KA + LAI+ G FIICWLPF I ++ + CN AL+ + WLGYVNS +NP+IYT F+ +FR AF KIL
Sbjct: 32 AMLLTLLIFVIVFGNVLVCIAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYMEVVGEWRFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISVVWVLSFAISCPLLF--------GLNNTASKVCIIDNP-AFVIYSSIVSFYVPFIVTLLVYVQIYIVLRK--RRKRVNTKRNSHGVEVNAHK---DKCTHPEDVKLC-----------------------AVFVKSNGSFPTDKKKVVSEAGNHPEDMDVEMMSS--------------------TSPPEKTKHKSAS-PNHHQLAVPATSNQCNNANLPSPVDSPYKAEKNGHPKDSTKPA--KVFEIQTMPNGKTRTSIKTMS-----------KRKLSQHKEKKATQMLAIVLGVFIICWLPFFIIHILNMHCNCN-IPQALYSAFT-WLGYVNSAVNPIIYTTFNVEFRKAFIKIL 438
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Xenopus
Match: ENSXETT00000046867.1 (5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled [Source:NCBI gene;Acc:100488829]) HSP 1 Score: 177.563 bits (449), Expect = 9.972e-49 Identity = 99/219 (45.21%), Postives = 141/219 (64.38%), Query Frame = 1
Query: 367 EYENVTESQIARFSPRLSWIQFYITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTD-INYLHRRTSSRIILMIIGVWLISVIISVPSRF--HTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIR 1014
E NVTE ++A LS+ +T+LFLG +IL I GN V+AAI LER L+ V+NYLI SLAV DLMV++LV+P++A +V + W LG CD++ DVL CT+SILHL IA+DRYWA+TD I+Y+++RT R ++I W++ IS+P T + ++ +C I+E YT++S GAFY+P+ M V+Y +I+ AR RIR
Sbjct: 15 ETGNVTEEEVA-----LSYQ--IVTSLFLGTLILCAIFGNACVIAAIALERCLQTVANYLIGSLAVTDLMVSVLVLPMAAHNQVLNKWTLGQVTCDIFISLDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISITWIVGFSISIPPMLGWRTPEDRSD------PNACKISEDPGYTIYSTFGAFYIPLILMLVLYGKIFKAARFRIR 220 HSP 2 Score: 84.3445 bits (207), Expect = 8.957e-17 Identity = 43/84 (51.19%), Postives = 53/84 (63.10%), Query Frame = 1
Query: 1603 RNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKIL 1854
+ KV RERK +TL II G FI CWLPF I + FC T LFD + WLGY NS LNP+IY F+ DF++AF+KI+
Sbjct: 321 KRKVALARERKTVKTLGIIMGTFIFCWLPFFIVALVLPFCETCHMPHLLFDVIN-WLGYSNSLLNPIIYAYFNKDFQSAFKKII 403
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Xenopus
Match: ENSXETT00000048394.1 (pep primary_assembly:Xenopus_tropicalis_v9.1:5:59937956:59939943:1 gene:ENSXETG00000020181.1 transcript:ENSXETT00000048394.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 169.474 bits (428), Expect = 1.185e-44 Identity = 141/523 (26.96%), Postives = 242/523 (46.27%), Query Frame = 1
Query: 427 QFYITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVT-DINYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIIN---ESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRI--------------------RYKRKKMKQNHCL-------SNTDHKSCTDQTKPTENTGQCPCNKRKIDEISYILNCEHCKLESLVIQNQNRKEWFDKHMSLLEFADEGENDSLSIQSNFYATTFANVKFENVDHVANVNCVGENDRNKAETMSNHSQKKINQTTNWSPKLIFYNYKAKLLNFKNDLSFKGSNKSSELQFNDDRSQSS---------LSFKDNKFNAMNSASIRNKVEQK------RERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKILL 1857
Q ++ A F G I L T+IGN+ V+ A + + LK V+NY +LSLA ADL++ ++ M + + W +G CDLW D ++ AS+++L+VI+ DRY+++T + Y +RT+ R +MI W+IS I+ P+ + R + + C I E + T + + AFYLP++ M+++Y RIY R R K N+ + S T + CT + KP C +K++I+ Q+Q+ E ++ + + + G +D N A +K + V + + K+++ + + K Q + PK + + K LN + +L K + S L D S ++ +SFK+ +A RN++ ++ +E+KAA+TL+ I FII W P+ I + + FC E C ++ +L WL Y+NS +NP+ Y + + FRT F+ +LL
Sbjct: 48 QVFLIASFSGIIALVTVIGNILVILAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMDHWIMGSLACDLWLMIDYVASNASVMNLLVISFDRYFSITRPLTYRTKRTTKRAGIMIGLAWIISFILWAPAILFWQYFVGK--RTVPSDECFIQFFTEPI-ITFGTAIAAFYLPVSIMTILYWRIYKETEKRTKELAGLQASGGKLEVPGLSHRTGNAKGNSNYKIQRNIKFSSRTRYSWCTFRFKPK----MCKSDKKQIE------------------QDQSSSESWNHNDANASLDNSGTSDEEDAPENPRAIYSIVLKLPGHNSVLS--------KTKSQSSNQGNTSKGMQKSGPQPKELRF----KNLNSQRNLQNKDESISVSLSPQTDHSMNTSSKTTAPLPISFKEIALAKRFAAKTRNQITKRKRMSLIKEKKAAQTLSAILLAFIITWAPYNIMVLVNTFC--ESCIPRIYWNLGYWLCYINSTINPICYALCNKTFRTTFKILLL 531
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Xenopus
Match: HTR1D (5-hydroxytryptamine receptor 1D [Source:HGNC Symbol;Acc:HGNC:5289]) HSP 1 Score: 155.221 bits (391), Expect = 4.958e-41 Identity = 94/192 (48.96%), Postives = 124/192 (64.58%), Query Frame = 1
Query: 442 ALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTD-INYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIIN-ESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRI 1011
A+ L I L T++ NVFV+ IV+ R L +NYLI SLA DL+V+ILVMPIS V+ TW G +CD+W D+ CTASILHL VIA+DRYWA+TD + Y RT+ R +MI+ VW+IS+ IS+P F E L V C IN + +SYT++S GAFY+P + ++Y +IYI ARSRI
Sbjct: 38 AVLLSIITLATLLSNVFVIITIVMTRKLHTPANYLIGSLAFTDLLVSILVMPISIAYTVTHTWTFGQIVCDIWLLSDITCCTASILHLCVIALDRYWAITDALEYTKHRTARRAAVMILVVWIISICISIPPLFWRQAKAHEELTV-----CTINTDQISYTIYSTCGAFYIPTVLLILLYGKIYIAARSRI 224 HSP 2 Score: 87.4261 bits (215), Expect = 6.965e-18 Identity = 46/131 (35.11%), Postives = 71/131 (54.20%), Query Frame = 1
Query: 1462 AKLLNFKNDLSFKGSNKSSELQFNDDRSQSSLSFKDNKFNAMNSASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKIL 1854
A+L+ SF N + ++ + S++ + K +S R ++ RE+KA +TL II G FI+CWLPF + ++ C L WLGY+NS +NPVIYTVF+ DF+ AF+K++
Sbjct: 238 AQLIPGSTGSSFCSINANVHME-HPHTSETPVCINHIKIKLADSIIERKRLSAAREKKATKTLGIILGAFIVCWLPFFVVSLVLPICRDACWFDPLLFDFFTWLGYLNSLINPVIYTVFNEDFKKAFQKLI 367
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Xenopus
Match: adra2c (adrenoceptor alpha 2C [Source:NCBI gene;Acc:100145449]) HSP 1 Score: 156.377 bits (394), Expect = 5.626e-41 Identity = 88/229 (38.43%), Postives = 131/229 (57.21%), Query Frame = 1
Query: 442 ALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTD-INYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHCLSNTDH---KSCTDQTKPTENTGQCP 1116
A +G +I++TI+GNVFVV A++ R LK N ++SLA AD++VA LVMP S E+ W+ G CD++ DVL CT+SI+HL I++DRYW+VT + Y +RT RI +I+ VWLIS +IS P R+ + V C +N+ Y + S +G+F+ P M ++Y+RIY A+ R R +K S+T++ K T + + G CP
Sbjct: 35 AAIVGFLIIFTIVGNVFVVIAVLTSRALKAPQNLFLVSLASADILVAALVMPFSLANELMGYWYFGNVWCDIYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRIKGIIVTVWLISAVISFPPLISMDRDTED----DVYPQCKLNDDTWYILSSCIGSFFAPCIIMILVYIRIYQVAKLRTRTLSEKKPTRDGSSHTENGFSKGTTVKMPGDKENGHCP 259 HSP 2 Score: 73.559 bits (179), Expect = 3.837e-13 Identity = 35/83 (42.17%), Postives = 50/83 (60.24%), Query Frame = 1
Query: 1612 VEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPC--GSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKIL 1854
+ Q RE++ LA++ G F++CW PF + + C E C LF W+GY NS LNPVIYT+F+ DFR +F+KI+
Sbjct: 343 LSQAREKRFTFVLAVVMGVFVVCWFPFFFSYSLYGICR-EACEVPETLFKFF-FWIGYCNSSLNPVIYTIFNQDFRRSFKKII 423
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Mouse
Match: Adra2b (adrenergic receptor, alpha 2b [Source:MGI Symbol;Acc:MGI:87935]) HSP 1 Score: 187.193 bits (474), Expect = 5.663e-52 Identity = 139/473 (29.39%), Postives = 216/473 (45.67%), Query Frame = 1
Query: 460 IILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTD-INYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNG--SCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHC--LSNTDHKSCTDQTKPTENTGQCPCNKRKIDEISYILNCEHCKLESLVIQNQNRKEWFDKHMSLLEFADEGENDSLSIQSNFYATTFANVKFENVDHVANVNCVGENDRNKAETMSNHSQKKINQTTNWSPKLIFYNYKAKLLNFKNDLSFKGSNKSSELQFNDDRSQSSLSFKDNKFNAMNSASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTE---PCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKIL 1854
+IL+TI GN V+ A++ R+L+ N ++SLA AD++VA L++P S E+ W+ C+++ DVL CT+SI+HL I++DRYWAV+ + Y +RT RI +I+ VWLI+ +IS+P + E +G C +N+ Y + S++G+F+ P M ++YLRIY+ A K++HC L + KP G P + + +S L S+ N + K +K +EGE ++ ++ + D + G AE ++ QT SP +F + + S L R Q LS + R + + RE++ LA++ G F++CW PF + A C P G LF W+GY NS LNPVIYT+F+ DFR AFR+IL
Sbjct: 22 LILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQRPE-----PHGLPQCELNQEAWYILASSIGSFFAPCLIMILVYLRIYVIA-----------KRSHCRGLGAKRGSGEGESKKPHPAAGGVPASAKVPTLVS--------PLSSVGEANGHPKPPREK--------EEGETPE-DPEARALPPNWSALPRSVQDQKKGTS--GATAEKGAEEDEEEVEECEPQTLPASPASVF------------NPPLQQPQTSRVL--ATLRGQVLLS---KNVGVASGQWWRRRTQLSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGAICPQHCKVPHG--LFQ-FFFWIGYCNSSLNPVIYTIFNQDFRRAFRRIL 439
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Mouse
Match: Adra2b (adrenergic receptor, alpha 2b [Source:MGI Symbol;Acc:MGI:87935]) HSP 1 Score: 187.193 bits (474), Expect = 6.781e-52 Identity = 139/473 (29.39%), Postives = 216/473 (45.67%), Query Frame = 1
Query: 460 IILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTD-INYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNG--SCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHC--LSNTDHKSCTDQTKPTENTGQCPCNKRKIDEISYILNCEHCKLESLVIQNQNRKEWFDKHMSLLEFADEGENDSLSIQSNFYATTFANVKFENVDHVANVNCVGENDRNKAETMSNHSQKKINQTTNWSPKLIFYNYKAKLLNFKNDLSFKGSNKSSELQFNDDRSQSSLSFKDNKFNAMNSASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTE---PCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKIL 1854
+IL+TI GN V+ A++ R+L+ N ++SLA AD++VA L++P S E+ W+ C+++ DVL CT+SI+HL I++DRYWAV+ + Y +RT RI +I+ VWLI+ +IS+P + E +G C +N+ Y + S++G+F+ P M ++YLRIY+ A K++HC L + KP G P + + +S L S+ N + K +K +EGE ++ ++ + D + G AE ++ QT SP +F + + S L R Q LS + R + + RE++ LA++ G F++CW PF + A C P G LF W+GY NS LNPVIYT+F+ DFR AFR+IL
Sbjct: 27 LILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQRPE-----PHGLPQCELNQEAWYILASSIGSFFAPCLIMILVYLRIYVIA-----------KRSHCRGLGAKRGSGEGESKKPHPAAGGVPASAKVPTLVS--------PLSSVGEANGHPKPPREK--------EEGETPE-DPEARALPPNWSALPRSVQDQKKGTS--GATAEKGAEEDEEEVEECEPQTLPASPASVF------------NPPLQQPQTSRVL--ATLRGQVLLS---KNVGVASGQWWRRRTQLSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGAICPQHCKVPHG--LFQ-FFFWIGYCNSSLNPVIYTIFNQDFRRAFRRIL 444
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Mouse
Match: Htr1a (5-hydroxytryptamine (serotonin) receptor 1A [Source:MGI Symbol;Acc:MGI:96273]) HSP 1 Score: 185.652 bits (470), Expect = 1.089e-51 Identity = 102/234 (43.59%), Postives = 143/234 (61.11%), Query Frame = 1
Query: 436 ITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTD-INYLHRRTSSRIILMIIGVWLISVIISVPS----RFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHCLSNTDHKSCTDQTKP---TENTGQC 1113
IT+L LG +I ++GN VVAAI LER+L+NV+NYLI SLAV DLMV++LV+P++A+ +V + W LG CDL+ DVL CT+SILHL IA+DRYWA+TD I+Y+++RT R +I WLI +IS+P R R+N C I++ YT++S GAFY+P+ M V+Y RI+ AR RIR KK+++ ++ S K +G C
Sbjct: 38 ITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSNPN--------ECTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKKGAGTSFGTSSAPPPKKSLNGQPGSGDC 263 HSP 2 Score: 83.5741 bits (205), Expect = 1.564e-16 Identity = 41/88 (46.59%), Postives = 54/88 (61.36%), Query Frame = 1
Query: 1591 SASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKIL 1854
+A + K+ RERK +TL II G FI+CWLPF I + FC + L ++ WLGY NS LNPVIY F+ DF+ AF+KI+
Sbjct: 328 TAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPELLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKII 415
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Mouse
Match: Drd2 (dopamine receptor D2 [Source:MGI Symbol;Acc:MGI:94924]) HSP 1 Score: 167.162 bits (422), Expect = 7.731e-45 Identity = 144/487 (29.57%), Postives = 205/487 (42.09%), Query Frame = 1
Query: 442 ALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTDINYLHRRTSS--RIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSR------------IRYKRKKMKQNHCLSNTDHKSCTDQTKPTENTGQCPCNKRKIDEISYILNCEHCKLESLVIQNQNRKEWFDKHMSLLEFADEGENDSLSIQSNFYATTFANVKFENVDHVANVNCVGENDRNKAETMSNHSQKKINQTTNWSPKLIFYNYKAKLLNFKNDLSFKGSNKSSELQFNDDRSQSSLSFKDNKFNAMNSASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNV--AHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKIL 1854
A+ L +I + GNV V A+ E+ L+ +NYLI+SLAVADL+VA LVMP EV W CD++ DV+ CTASIL+L I+IDRY AV + R SS R+ +MI VW++S IS P F NN + CII ++ V+S++ +FY+P ++Y++IYI R R R K + +C D K CT K + G P N+R++D E L S + R L D + + N + A+ N K +N P++ + + N K S K ++ Q + ++ L+ I+ G FIICWLPF I ++ H CN P + F WLGYVNS +NP+IYT F+ +FR AF KIL
Sbjct: 38 AMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGL--NNTD------QNECIIANP-AFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMK---SNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHG-----------------------------LHSNPDSPAKPEKNGHAKIVN------PRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLA-------------------------------IVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFT----WLGYVNSAVNPIIYTTFNIEFRKAFMKIL 442
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Mouse
Match: Htr1b (5-hydroxytryptamine (serotonin) receptor 1B [Source:MGI Symbol;Acc:MGI:96274]) HSP 1 Score: 159.073 bits (401), Expect = 1.895e-42 Identity = 86/178 (48.31%), Postives = 112/178 (62.92%), Query Frame = 1
Query: 484 NVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTD-INYLHRRTSSRIILMIIGVWLISVIISVPSRF-HTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRI 1011
N FV+A + R L +NYLI SLAV DL+V+ILVMPIS + V+ W LG +CD W D+ CTASI+HL VIA+DRYWA+TD + Y +RT R +MI+ VW+ S+ IS+P F + E L VN + V YTV+S +GAFYLP + +Y RIY+ ARSRI
Sbjct: 63 NAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIMHLCVIALDRYWAITDAVEYSAKRTPKRAAIMIVLVWVFSISISLPPFFWRQAKAEEEMLDCFVN-----TDHVLYTVYSTVGAFYLPTLLLIALYGRIYVEARSRI 235 HSP 2 Score: 78.1814 bits (191), Expect = 6.109e-15 Identity = 40/86 (46.51%), Postives = 56/86 (65.12%), Query Frame = 1
Query: 1603 RNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPC--GSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKIL 1854
+ K+ RERKA +TL II G FI+CWLPF I ++ C + C A+FD WLGY+NS +NP+IYT+ + DF+ AF K++
Sbjct: 297 KKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICK-DACWFHMAIFDFFN-WLGYLNSLINPIIYTMSNEDFKQAFHKLI 380
BLAST of 5-hydroxytryptamine receptor vs. UniProt/SwissProt
Match: sp|Q25414|5HTR_LYMST (5-hydroxytryptamine receptor OS=Lymnaea stagnalis OX=6523 PE=2 SV=1) HSP 1 Score: 316.62 bits (810), Expect = 3.783e-99 Identity = 193/488 (39.55%), Postives = 261/488 (53.48%), Query Frame = 1
Query: 427 QFYITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTDINYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHCLSNTDHKSCTDQTKPTENTGQCPCNKRKIDEISYILNCEHCKLESLVIQNQNRKEWFDKHMSLLEFADEGENDSLSIQSNFYATTFANVKFENVDHVANVNCVGENDRNKAETMSNHSQKKINQTTNWSPKLIFYNYKAKLLN------FKNDLSFKGSNKSSELQFNDDRSQSSLSFKDNKFNAMNSASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALF-DSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKILLGHYH 1869
+T++ LG +L IIGN FV+AA++LER+L NV+NYLILSLAVADLMVA+LVMP+S + E+S W+L E+CD+W DVL CTASILHLV IA+DRYWAVT I+Y+ RR++ RI+LMI+ VW++++ IS+P F N + + G+CII++ YT+FS +GAFYLPM M +IY+RI++ ARSRIR + +M T TE T K E S + +C C + + R+ F + C +R K + KK+ + N + + K + F N + + S E Q N+ + SS N + R K+E KRERKAARTLAIITG F+ICWLPF I + F + E G F S LWLGY NS LNP+IYT+FSP+FR+AF+KIL G Y
Sbjct: 94 HLVLTSVILGLFVLCCIIGNCFVIAAVMLERSLHNVANYLILSLAVADLMVAVLVMPLSVVSEISKVWFLHSEVCDMWISVDVLCCTASILHLVAIAMDRYWAVTSIDYIRRRSARRILLMIMVVWIVALFISIPPLFGWRDPNNDPDK---TGTCIISQDKGYTIFSTVGAFYLPMLVMMIIYIRIWLVARSRIRKDKFQM--------------TKARLKTEETTLVASPK---TEYSVVSDCNGCNSPDSTTEKKKRRAPFKSY----------------------------------------GCSPRPERKK------NRAKKLPENANGVNSNSSSSERLKQIQIETAEAFANGCAEEASIAMLERQCNNGKKISS--------NDTPYSRTREKLELKRERKAARTLAIITGAFLICWLPFFIIALIGPFVDPE--GIPPFARSFVLWLGYFNSLLNPIIYTIFSPEFRSAFQKILFGKYR 505
BLAST of 5-hydroxytryptamine receptor vs. UniProt/SwissProt
Match: sp|P22270|OAR_DROME (Tyramine/octopamine receptor OS=Drosophila melanogaster OX=7227 GN=Oct-TyrR PE=2 SV=2) HSP 1 Score: 231.106 bits (588), Expect = 7.135e-66 Identity = 154/497 (30.99%), Postives = 253/497 (50.91%), Query Frame = 1
Query: 436 ITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTD-INYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGS-CIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNH-CLSNTDHKSCTDQTK-PTENTGQCPCNKRKIDEISYILNCEHCKLESLVIQNQNRKEWFDKHMSLLEFADEGENDSLSIQSNFYATTFANVKFENVDHVANVNCVGENDRNKAETMSNHSQKKINQTTNWSPKLIFYNYKAKLLNFKNDLSFK-GSNKSSELQFNDDRSQSSLSFK------DNKFNAMNSASIRNK-------VEQK------RERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKIL 1854
+TAL L II+ TIIGN+ V+ ++ + L+ V N+ I+SLAVADL VA+LV+P + + W GI LC LW DVL CT+SIL+L IA+DRYWA+TD INY +RT R++L+I GVWL+S++IS P + +W + + C + Y ++S+LG+F++P+A M+++Y+ I++ R R+R + + K N L +T+ + + + N+G +K ++ + + + +IQN + H +S Q + + + + D + + G + T H ++++ + ++S + GS+ +Q ++ S K A++ ++ K +E+K +ER+AARTL II G F+ICWLPF + V FC T C + F + WLGY+NSGLNPVIYT+F+ D+R AF+++L
Sbjct: 111 LTALVLSVIIVLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVAYSILGRWEFGIHLCKLWLTCDVLCCTSSILNLCAIALDRYWAITDPINYAQKRTVGRVLLLISGVWLLSLLISSPPLIGWN----DWPDEFTSATPCELTSQRGYVIYSSLGSFFIPLAIMTIVYIEIFVATRRRLRERARANKLNTIALKSTELEPMANSSPVAASNSG----SKSRLLASWLCCGRDRAQFATPMIQNDQESISSETHQPQDSSKAGPHGNSDPQQQHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQSSSTCEPHGEQQLLPAGGDGGSCQPGGGHSGGGKSDAEISTESGSDPKGCIQVCVTQADEQTSLKLTPPQSSTGVAAVSVTPLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIMGVFVICWLPFFLMYVILPFCQTC-CPTNKFKNFITWLGYINSGLNPVIYTIFNLDYRRAFKRLL 598
BLAST of 5-hydroxytryptamine receptor vs. UniProt/SwissProt
Match: sp|Q17232|OAR_BOMMO (Octopamine receptor OS=Bombyx mori OX=7091 PE=2 SV=1) HSP 1 Score: 226.098 bits (575), Expect = 4.091e-65 Identity = 151/487 (31.01%), Postives = 240/487 (49.28%), Query Frame = 1
Query: 439 TALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTD-INYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVI-VNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHCLSN-----------TDHKSCTDQTKPTENTGQCPCNKRKIDEISYILNCEHCKLESLVIQNQNRKEWFDKHMSLLEFADEGEND-SLSIQSNFYATTFANVKFENVDHVANVNCVGENDRNKAETMSNHSQKKINQTTNWSPKLIFYNYKAKLLNFKNDLSFKGSNKSSELQFNDDRSQSSLSFKDNKFNAMNSASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKILL 1857
TA+ L II+ T++GN+ V+ ++ + L+ V N+ I+SLAVADL VAILV+P++ + W GI +C +W D++ CT+SIL+L IA+DRYWA+TD INY +RT R++ MI VW++S++IS P + +W V + C + + +FS+ G+FY+P+ M+V+Y IY+ + R+R + K K + S D S + P E+ G R + E N + + L + + ++ ++ K D+ N + I SN + T EN + + N ++ N E ++ + KI + K + ++ QF +++ + SL+ RER+AARTL II G F++CWLPF + + FC C S F + WLGYVNS LNP+IYT+F+ DFR AF+K+L
Sbjct: 57 TAIILTMIIISTVVGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVAILVLPLNVAYSILGQWVFGIYVCKMWLTCDIMCCTSSILNLCAIALDRYWAITDPINYAQKRTLERVLFMIGIVWILSLVISSPPLLGWN----DWPEVFEPDTPCRLTSQPGFVIFSSSGSFYIPLVIMTVVYFEIYLATKKRLRDRAKATKISTISSGRNKYETKESDPNDQDSVSSDANPNEHQG----GTRLVAE-----NEKKHRTRKLTPKKKPKRRYWSKD-------DKSHNKLIIPILSNENSVTDIGENLENRNTSSESNSKETHEDNMIE-ITEAAPVKIQKRP------------------------KQNQTNAVYQFIEEKQRISLT---------------------RERRAARTLGIIMGVFVVCWLPFFVIYLVIPFC-VSCCLSNKFINFITWLGYVNSALNPLIYTIFNMDFRRAFKKLLF 476
BLAST of 5-hydroxytryptamine receptor vs. UniProt/SwissProt
Match: sp|Q25188|OAR_HELVI (Octopamine receptor OS=Heliothis virescens OX=7102 PE=2 SV=1) HSP 1 Score: 225.713 bits (574), Expect = 5.202e-65 Identity = 158/482 (32.78%), Postives = 246/482 (51.04%), Query Frame = 1
Query: 439 TALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTD-INYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVI-VNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMK-------QNHCLSNTDHKSCTDQTKPTENTGQCPCNKRKIDEISYILNCEHCKLESLVIQNQNRKEWFDKHMSLLEFADEGENDS-LSIQSNFYATTFANVKFENVDHVANVNCVGENDRNKAETMSNHSQKKINQTTNWSPKLIFYNYKAKLLNFKNDLSFKGSNKSSELQFNDDRSQSSLSFKDNKFNAMNSASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKIL 1854
TA+ L II+ TI+GN+ V+ ++ + L+ V N+ I+SLAVADL VAILV+P++ + W GI +C +W D++ CT+SIL+L IA+DRYWA+TD INY +RT R++LMI VW++S+IIS P + +W V + C + + +FS+ G+FY+P+ M+V+Y IY+ + R+R + K K QN + DH D N + R + + N + + L + + +++++ K D+ +N + I SN EN +V +GEN N+ T S + K+ ++ LI N + K + +S+ QF +++ + SL+ RER+AARTL II G F++CWLPF + + FC C S F + WLGY NS LNP+IYT+F+ DFR AF+K+L
Sbjct: 55 TAIVLTLIIISTIVGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVAILVLPLNVAYSILGQWVFGIYVCKMWLTCDIMCCTSSILNLCAIALDRYWAITDPINYAQKRTLERVLLMIGVVWVLSLIISSPPLLGWN----DWPDVFEPDTPCRLTSQPGFVIFSSSGSFYIPLVIMTVVYFEIYLATKKRLRDRAKATKISTISSGQNKYNNKDDHHD-QDSVSSEANHNEHQGVTRLVSD-----NEKKKRTRKLTPKKKPKRKYWSKD-------DKSQNKLIIPILSN-----------EN-----SVTDMGENLENR-NTSSESNSKETHED-----DLIEVNETVPVKTHHKKP--KPNQQSAVYQFIEEKQRISLT---------------------RERRAARTLGIIMGVFVVCWLPFFVIYLVIPFC-ASCCLSNKFINFITWLGYCNSALNPLIYTIFNMDFRRAFKKLL 473
BLAST of 5-hydroxytryptamine receptor vs. UniProt/SwissProt
Match: sp|P28285|5HT2A_DROME (5-hydroxytryptamine receptor 2A OS=Drosophila melanogaster OX=7227 GN=5-HT1A PE=2 SV=2) HSP 1 Score: 214.927 bits (546), Expect = 2.220e-58 Identity = 107/210 (50.95%), Postives = 150/210 (71.43%), Query Frame = 1
Query: 376 NVTESQIAR--FSPRLSWIQFYITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTDINYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFA 999
NVT S++A F+ ++ +T++ LG +IL TIIGNVFV+AAI+LER L+NV+NYL+ SLAVADL VA LVMP+ A+ E+S W LG ELCD+WT DVL CTASILHLV IA+DRYWAVT+I+Y+H RTS+R+ +MI VW +VI+S+ +F + ++L+ I C++++ VSY VF+ FY+P+ + +Y +IY A
Sbjct: 209 NVTTSKVAEDDFT---QLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTNIDYIHSRTSNRVFMMIFCVWTAAVIVSLAPQF--GWKDPDYLQRIEQQKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIYQTA 413 HSP 2 Score: 105.145 bits (261), Expect = 4.879e-22 Identity = 52/98 (53.06%), Postives = 65/98 (66.33%), Query Frame = 1
Query: 1603 RNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCG-SALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKILLG-----HYHTRR 1878
+ +E KRERKAA+TLAIITG F++CWLPF + + C C S SL LWLGY NS LNPVIYT+FSP+FR AF++IL G HY + +
Sbjct: 738 KETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAA--CQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRILFGGHRPVHYRSGK 833
BLAST of 5-hydroxytryptamine receptor vs. TrEMBL
Match: A0A193KU56 (GCR006 OS=Schmidtea mediterranea OX=79327 GN=gcr006 PE=2 SV=1) HSP 1 Score: 1061.21 bits (2743), Expect = 0.000e+0 Identity = 513/513 (100.00%), Postives = 513/513 (100.00%), Query Frame = 1
Query: 352 MVLFYEYENVTESQIARFSPRLSWIQFYITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTDINYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHCLSNTDHKSCTDQTKPTENTGQCPCNKRKIDEISYILNCEHCKLESLVIQNQNRKEWFDKHMSLLEFADEGENDSLSIQSNFYATTFANVKFENVDHVANVNCVGENDRNKAETMSNHSQKKINQTTNWSPKLIFYNYKAKLLNFKNDLSFKGSNKSSELQFNDDRSQSSLSFKDNKFNAMNSASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKILLGHYHTRRCLKC 1890
MVLFYEYENVTESQIARFSPRLSWIQFYITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTDINYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHCLSNTDHKSCTDQTKPTENTGQCPCNKRKIDEISYILNCEHCKLESLVIQNQNRKEWFDKHMSLLEFADEGENDSLSIQSNFYATTFANVKFENVDHVANVNCVGENDRNKAETMSNHSQKKINQTTNWSPKLIFYNYKAKLLNFKNDLSFKGSNKSSELQFNDDRSQSSLSFKDNKFNAMNSASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKILLGHYHTRRCLKC
Sbjct: 1 MVLFYEYENVTESQIARFSPRLSWIQFYITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTDINYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHCLSNTDHKSCTDQTKPTENTGQCPCNKRKIDEISYILNCEHCKLESLVIQNQNRKEWFDKHMSLLEFADEGENDSLSIQSNFYATTFANVKFENVDHVANVNCVGENDRNKAETMSNHSQKKINQTTNWSPKLIFYNYKAKLLNFKNDLSFKGSNKSSELQFNDDRSQSSLSFKDNKFNAMNSASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKILLGHYHTRRCLKC 513
BLAST of 5-hydroxytryptamine receptor vs. TrEMBL
Match: A0A193KUG6 (GCR020 OS=Schmidtea mediterranea OX=79327 GN=gcr020 PE=2 SV=1) HSP 1 Score: 317.39 bits (812), Expect = 2.593e-96 Identity = 204/566 (36.04%), Postives = 307/566 (54.24%), Query Frame = 1
Query: 388 SQIARFSPRLSWIQFYITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTDINYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRNN-AEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHCLSNTDHKSCTDQTKPTENTGQCPCNKRKI-----DEISYILNCEHCKLESLVIQNQNRKEWFDKHMSLLEFAD-EGENDS-------------------------------------LSIQSNFYATT--------------FANVKFENVDHVANVNCVGENDRNKAETMSNHSQKKINQTTNWSPKLIFYNYKAKLLNFKNDLSF---------------KGSNKSSELQFNDDRSQSSLSFKDNKFNAMNSASIR-NKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCG-SALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKILLG 1860
+Q ++ PR + +L L II+WTI GNV V+ IV E +KN SN+LI SLAV DL VA+ VMP+SAIKEVS WWLG+ELCD+W DVL+CTASI HLVVIAIDRY ++T + Y R++ MI W+ + ++S+PSRF+ RNN AE + V NG+C+INE SYT+ +N +F P+ M ++Y +I+IF + + + RK +K + S+ + +++T P + +I D+ I+ + ES V ++ + +W ++ S ++AD E EN S + S+ Y T+ +K++N D + + N ++++ + +++S+K + T +WSPKL F+ Y+ + KN +F K N S+ F ++Q S S DN F ++ ++R ++ QKRE K RTL IITG FIICWLPF INN+ A+ ++P + + DS+ LWLGYVNSGLNP+IYT+FS +F+ AF+KIL G
Sbjct: 8 TQPVQYEPRFQIWPMTLISLLLIIIIIWTIAGNVLVMVTIVTELNIKNSSNHLIFSLAVTDLFVAVAVMPLSAIKEVSIKWWLGLELCDIWIFTDVLTCTASIFHLVVIAIDRYLSITKLTYNRNRSTVSTTAMITSSWIAAALVSIPSRFYLQRNNTAERITVNYNGTCLINEGNSYTILANFLSFCFPLILMGIVYFKIFIFIKKQTK-NRKAIKNSVIGSDALSTTFASDICYSKSTAS-PFPQSEIWSSIYDDSKIII--DENSFESTVTESLEKTKWVNEECSNFQYADEEDENQSKSNNNLSENVTNKYLYCLDKSSTESFPMSSLYLNPLTMKTYSDIYTTSNLAKTETMSTIEGEIFPLKYQNKDILKSPN----SNKSIIKPSTSNSRKLKSPTLSWSPKLTFFPYRQSKPSIKNGFNFVEANYSLLSSISSPLKNHNHSNNEHF---QTQISDSLNDNSFASL---AVRVKRINQKREYKVVRTLFIITGLFIICWLPFAINNLLRAYVISDPSEINRIMDSIFLWLGYVNSGLNPIIYTIFSTEFQVAFKKILFG 559
BLAST of 5-hydroxytryptamine receptor vs. TrEMBL
Match: Q6TKQ2 (Type 1 serotonin receptor 5HT-1Hel OS=Planorbella trivolvis OX=283763 PE=2 SV=1) HSP 1 Score: 313.538 bits (802), Expect = 1.401e-95 Identity = 185/478 (38.70%), Postives = 254/478 (53.14%), Query Frame = 1
Query: 436 ITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTDINYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHCLSNTDHKSCTDQTKPTENTGQCPCNKRKIDEISYILNCEHCKLESLVIQNQNRKEWFDKHMSLLEFADEGENDSLSIQSNFYATTFANVKFENVDHVANVNCVGENDRNKAETMSNHSQKKINQTTNWSPKLIFYNYKAKLLNFKNDLSFKGSNKSSELQFNDDRSQSSLSFKDNKFNAMNSASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKILLGHYH 1869
+T++ LG +L IIGN FV+AA++LER+L NV+NYLILSLAVADLMVA+LVMP+S + E+S W+L E+CD+W DVL CTASILHLV IA+DRYWAVT I+Y+ RR++ RI+LMI+ VW++++ IS+P F N + + G CII++ YT+FS +GAFYLPM M +IY+RI++ ARSRIR D T TE T K E S + +C C + + R+ F + C +R K N ++K QT S + + K + + + G + + + + + + N+ + + R K+E KRERKAARTLAIITG F++CWLPF I + F P S LWLGY NS LNP+IYT+FSP+FR AF+KIL G Y
Sbjct: 93 VTSVILGLFVLCCIIGNCFVIAAVILERSLHNVANYLILSLAVADLMVAVLVMPLSVVSEISQVWFLHSEVCDMWISVDVLCCTASILHLVAIAMDRYWAVTSIDYIRRRSARRILLMIMVVWIVALFISIPPLFGWRDPNND---PAITGQCIISQDKGYTIFSTVGAFYLPMLVMMIIYIRIWLVARSRIR--------------KDKFQLTKARLKTEETTLVASPK---TEYSVVSDCNGCNSPESTAEKKKRRAPFKSY----------------------------------------GCSPRPERKK-----NRNKKLPEQTNGVSSSNSSCSERLKQIQIEPEGFTNGCAEEASIAMLERQCNNGKKISSNE--SAPYSRTREKLELKRERKAARTLAIITGAFLVCWLPFFIIALIGPFVGWIP---PFVRSFVLWLGYFNSLLNPIIYTIFSPEFRIAFQKILFGKYR 500
BLAST of 5-hydroxytryptamine receptor vs. TrEMBL
Match: Q8MX83 (G-protein-coupled 5-hydroxytryptamine receptor 2 OS=Aplysia californica OX=6500 PE=2 SV=1) HSP 1 Score: 312.768 bits (800), Expect = 1.704e-94 Identity = 187/480 (38.96%), Postives = 260/480 (54.17%), Query Frame = 1
Query: 427 QFYITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTDINYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHCLSNTDHKSCTDQTKPTENTGQCPCNKRKIDEISYILNCEHCKLESLVIQNQNRKEWFDKHMSLLEFADEGENDSLSIQSNFYATTFANVKFENVDHVANVNCVGENDRNKAETMSNHSQKKINQTTNWSPKLIFYNYKAKLLNFKNDLSFKGSNKSSELQFNDDRSQSSLSFKDNKFNAMNSASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKILLGHY 1866
+T++ LG +L IIGN FV+AA++LER+L NV+NYLILSLAVADLMVA+LVMP+S + E+S W+L E+CD+W DVL CTASILHLV IA+DRYWAVT I+Y+ RR++ I+LMI VW++++ I +P F N + + G CII++ YT+FS +GAFYLPMA M VIY RIY ARSRIR + K +Q T+ + K E S + +C C + + + R + K + +N + + + + + V+ E AN E+ N + + ++ Q + D G N + + + + ++ N + A R K+E KRERKAARTLAIITG F+ICWLPF I + F + E S LWLGY NS LNP+IYT+FSP+FR+AF+KIL G Y
Sbjct: 126 HLIVTSIILGLFVLCCIIGNCFVIAAVILERSLHNVANYLILSLAVADLMVAVLVMPLSVVSEISQVWFLHQEVCDMWISVDVLCCTASILHLVAIAMDRYWAVTSIDYIRRRSARCILLMITVVWIVALFICIPPIFGWRDPNND---SDITGKCIISQDKGYTIFSTVGAFYLPMAVMMVIYTRIYQVARSRIR--KDKFQQTKANMKTEETTLVASPK---------------TEYSVVSDCNGCSPRNDHEKKKRRAPF--KSYGCSPRPERKKNRNKKLTTAYAERSCTVVEPEPSSEQANGLSCSESADNALSASDSGNNIRLKQI------------------IEPDAFTNGCNDEANIAMLERQCKNGKKISANDLTPYSRA--REKLELKRERKAARTLAIITGAFLICWLPFFIIALIGPFVD-ERNIPIFARSFVLWLGYFNSLLNPIIYTIFSPEFRSAFQKILFGKY 562
BLAST of 5-hydroxytryptamine receptor vs. TrEMBL
Match: A0A433UE96 (G_PROTEIN_RECEP_F1_2 domain-containing protein OS=Elysia chlorotica OX=188477 GN=EGW08_000169 PE=3 SV=1) HSP 1 Score: 305.449 bits (781), Expect = 7.411e-92 Identity = 189/491 (38.49%), Postives = 263/491 (53.56%), Query Frame = 1
Query: 436 ITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTDINYLHRRTSSRIILMIIGVWLISVIISVPSRF--HTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHCLSNTDHKSCTDQTKP-TENTGQCPCNKRKIDEISYILNCEHCKLESLVIQNQNRKEWFDKHMSLLEFADEGENDSLSIQSNFYATTFANVKFENVDHVANVNCVGENDRNKAETMSNHSQKKINQTTNWSPKLIFYNYKAKLLNFKNDLSFKGSNKSSELQFNDDRSQSSLSFKDNKFNAMNSAS----------IRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKILLGHYH 1869
+T++ LG +L IIGN FV+AA++LER+L NV+NYLILSLAVADLMVA+LVMP+S + E+S W+L E+CD+W DVL CTASILHLVVIA+DRYWAVT I+Y+ RR++ RI+LMI VW++++ IS+P F N+ + G CII++ YT+FS +GAFYLPM M +IY RI+ ARSRIR + + +++P TE T K + +S NC C V + + K + + + A V+ ++ +NV+ E +N +Q + + P + K + K D++S + L + + N N +S R K+E KRERKAARTLAIITG F+ICWLPF + + F + S LWLGY NS LNP+IYT+FSP+FR+AF+KIL G Y
Sbjct: 102 LTSVILGLFVLCCIIGNCFVIAAVILERSLHNVANYLILSLAVADLMVAVLVMPLSVVSEISKVWFLHSEVCDMWISVDVLCCTASILHLVVIAMDRYWAVTSIDYIRRRSARRILLMITLVWIMALFISIPPLFGWRDPDNDPD-----ATGQCIISQDKGYTIFSTVGAFYLPMLVMMIIYTRIWQVARSRIRKDKFQ---------------GGKSRPKTEETTLVASPKTEYSMVS--ANCNGCGSPESVNGGKKKSRIRLKSYGCSPRPERKKKGQV-----------AKVQQQHSRCPSNVSVDLET--------TNGAQGSLGGSVASVPSMPSLPPTPKCEHLKQLPPVAIEPDPFTNGCEDEQSIAMLE-RHERTNGNNGSSATANYTPYSRTREKLELKRERKAARTLAIITGAFLICWLPFFVIALIGPFIDNPGNIPDFARSFVLWLGYFNSLLNPIIYTIFSPEFRSAFQKILFGKYR 550
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Cavefish
Match: drd2a (D(2)-like dopamine receptor [Source:NCBI gene;Acc:103036974]) HSP 1 Score: 184.111 bits (466), Expect = 5.085e-51 Identity = 154/492 (31.30%), Postives = 236/492 (47.97%), Query Frame = 1
Query: 427 QFYITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTDINYLHRRTSS--RIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHCLSNTDHKSCTDQTKPTENTGQCPCNKRKIDEISYILNCEH---CKLESLVIQNQNRKEWFDKHMSLLEFADEGENDSLSIQSNFYATTFANVKFENVDHVANVNCVGENDRNKAET---------MSNHSQKKINQTTNWSPKLIFYNYKAKLLNFKNDLSFKGSNKSSELQFNDD-RSQSSL-SFKDNKFNAMNSASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKIL 1854
Q+ A+ L +I + GNV V A+ E+ L+ +NYLI+SLAVADL+VA LVMP EV W CD++ DV+ CTASIL+L I+IDRY AV + R SS R+ +MI VW++S IS P F NN E + C+I ++ V+S++ +FY+P ++Y++IY+ R R RK++ T +T P+ + K+ C H KL ++++++ +K++ F E N++ +Q+ D V N + N R +T +S HS+ ++ T +P K N K+ E Q + ++QSS+ SF KF+ Q++E+KA + LAI+ G FIICWLPF I ++ + + N + L+ + WLGYVNS +NP+IYT F+ +FR AF KIL
Sbjct: 31 QYNYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSTIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSRRRVTVMISVVWILSFAISCPLLFGL--NNTESRD---DALCVIANP-AFVVYSSIVSFYVPFIITLLVYVQIYVVLRKR----RKRVS-------------TKRTFPSSTAERGTTLKK----------CTHPDDVKLCTVIVKSNGNFPVNNKNVI---FIKEVVNNADDVQA---------------DEVTNPEPL--NQRTLEQTGASQHGLLLVSTHSETEVLPTVPEAP--------IKPSRNGNTGDAPRVTKAFETQVSPSGKTQSSVKSFNKRKFS------------QQKEKKATQMLAIVLGVFIICWLPFFITHIVNTYYNVP---AELYTAFT-WLGYVNSAVNPIIYTTFNIEFRKAFIKIL 445
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Cavefish
Match: drd2b (D(2) dopamine receptor A [Source:NCBI gene;Acc:103035621]) HSP 1 Score: 182.185 bits (461), Expect = 3.355e-50 Identity = 147/485 (30.31%), Postives = 226/485 (46.60%), Query Frame = 1
Query: 427 QFYITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTDINYLHRRTSS--RIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIINESV------SYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHCLSNTDHKSCTDQTKPTENTGQCPCNKRKIDEISYILNCEHCKLESLVIQNQNRKEWFDKHMSLLEFADEGENDSLSIQSNFYATTFANVKFENVDHVANVNCVGENDRNKAETMSNHSQKKINQTTNWSPKLIFYNYKAKLLNFKNDLSFKGSNKSSELQ-FNDDRSQSSLSFKDNKFNAMNSASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKIL 1854
Q+ A+ L +I + GNV V A+ E+ L+ +NYLI+SLAVADL+VA LVMP EV W CD++ DV+ CTASIL+L I+IDRY AV + R SS R+ +MI VW++S IS P F +N + ++SV ++ V+S++ +FY+P ++Y++IY+ R R KR K+N C K+ + P + P E KL +++++ +K LL E ++ +T K + A VN + + A + H + W P N AK D KS E Q + +++++++ +K K+ Q +E+KA + LAI+ G FIICWLPF I ++ C + ++++ WLGYVNS +NP+IYT F+ +FR AF KIL
Sbjct: 31 QYNYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSKIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISVVWVLSFAISCPLLFG------------LNNTATRDDSVCEIANPAFVVYSSIMSFYVPFIITLLVYVQIYVVLRK--RRKRVNTKRN-C-----QKADAEPQPPLKEKCTHP---------------EDVKLCTVIVKTNGSLPVKNKKAQLL--IKEVVQPGTGVEMGLMTSTSPPEKMKLAAPPA-VNLLATQSPSHASPL--HEE--------WQPHDDEKNGHAK------DAQTPKETKSFETQALPNGKTRTTVTKTMSK----------RKMSQHKEKKATQMLAIVLGVFIICWLPFFITHILKTHCTSCYVPLEMYNAFT-WLGYVNSAVNPIIYTTFNVEFRKAFMKIL 450
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Cavefish
Match: drd2a (D(2)-like dopamine receptor [Source:NCBI gene;Acc:103036974]) HSP 1 Score: 179.874 bits (455), Expect = 1.449e-49 Identity = 152/483 (31.47%), Postives = 227/483 (47.00%), Query Frame = 1
Query: 427 QFYITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTDINYLHRRTSSR--IILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHCLSNTDHKSCTDQTKPTENTGQCPCNKRKIDEISYILNCEH---CKLESLVIQNQNRKEWFDKHMSLLEFADEGENDSLSIQSNFYATTFANVKFENVDHVANVNCVGENDRNKAETMSNHSQKKINQTTNWSPKLIFYNYKAKLLNFKNDLSFKGSNKSSELQFNDD-RSQSSL-SFKDNKFNAMNSASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKIL 1854
Q+ A+ L +I + GNV V A+ E+ L+ +NYLI+SLAVADL+VA LVMP EV W CD++ DV+ CTASIL+L I+IDRY AV + R SSR + +MI VW++S IS P F NN E + C+I ++ V+S++ +FY+P ++Y++IY+ R R RK++ T +T P N N K C H KL ++++++ +K++ ADE N Q T ++ +S HS+ ++ T +P K N K+ E Q + ++QSS+ SF KF+ Q++E+KA + LAI+ G FIICWLPF I ++ + + N + L+ + WLGYVNS +NP+IYT F+ +FR AF KIL
Sbjct: 21 QYNYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSTIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSRRRVTVMISVVWILSFAISCPLLFGL--NNTESRD---DALCVIANP-AFVVYSSIVSFYVPFIITLLVYVQIYVVLRKR----RKRVS-------------TKRTFPKFNVH---LNSPK---------CTHPDDVKLCTVIVKSNGNFPVNNKNVVCQISADEVTNPEPLNQRTLEQT--------------------GASQHGLLLVSTHSETEVLPTVPEAP--------IKPSRNGNTGDAPRVTKAFETQVSPSGKTQSSVKSFNKRKFS------------QQKEKKATQMLAIVLGVFIICWLPFFITHIVNTYYNVP---AELYTAFT-WLGYVNSAVNPIIYTTFNIEFRKAFIKIL 424
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Cavefish
Match: ENSAMXT00000026144.2 (pep primary_assembly:Astyanax_mexicanus-2.0:9:14357937:14360657:1 gene:ENSAMXG00000025418.2 transcript:ENSAMXT00000026144.2 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 175.252 bits (443), Expect = 1.790e-48 Identity = 100/215 (46.51%), Postives = 137/215 (63.72%), Query Frame = 1
Query: 373 ENVTESQIARFSPRLSWIQFYITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTD-INYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIIN-ESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRI 1011
+++TE A L +Q ++AL L + L T++ N FV+A I L R L +N+LI SLA+ DL+V+ILVMPIS + VS TW LG +CD+W D+ CTASILHL VIA+DRYWA+TD + Y RRT+ R LMI VW+IS+ IS+P F E L C++N + +SYT++S GAFY+P + ++Y RIY+ ARSRI
Sbjct: 7 QSLTEDSEAWDEATLLGLQISLSAL-LAVVTLATMLSNAFVIATIFLTRKLHTPANFLIGSLALTDLLVSILVMPISIVYTVSKTWTLGQIMCDIWLSSDITFCTASILHLCVIALDRYWAITDALEYSKRRTTRRAALMIGVVWVISISISIPPLFWRQAKAHEELT-----ECLVNTDQISYTLYSTFGAFYVPTILLVILYGRIYVAARSRI 215 HSP 2 Score: 83.5741 bits (205), Expect = 7.888e-17 Identity = 41/94 (43.62%), Postives = 57/94 (60.64%), Query Frame = 1
Query: 1573 KFNAMNSASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKIL 1854
K +S R ++ RE+KA +TL II G FI+CWLPF + + A C LFD WLGY+NS +NPVIYT F+ +F+ AF+K++
Sbjct: 272 KVKLADSVLERKRLCAAREKKATKTLGIILGAFIVCWLPFFVVTLVMAICKDCWFHPVLFDFFT-WLGYLNSLINPVIYTAFNDEFKQAFQKLI 364
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Cavefish
Match: htr1ab (5-hydroxytryptamine (serotonin) receptor 1A b [Source:ZFIN;Acc:ZDB-GENE-090409-2]) HSP 1 Score: 176.022 bits (445), Expect = 2.447e-48 Identity = 92/207 (44.44%), Postives = 134/207 (64.73%), Query Frame = 1
Query: 439 TALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTD-INYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNG-SCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHCLS 1053
T++ +GA+IL ++ GN VVAAI LER+L+NV+NYLI SLAV DLMV++LV+P++ + +V W LG CD++ D+L CT+SILHL IA+DRYWA+TD I+Y+ +RT R ++I WL+ IS+P I N +C+I+ YT++S AFY+P+ M V+Y RI+ AR RIR +K ++ CL+
Sbjct: 40 TSVLIGALILCSVFGNSCVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMACLYQVLDRWTLGQVTCDIFISLDILCCTSSILHLCAIALDRYWAITDPIDYMKKRTLKRAAVLIGVTWLVGFSISIPPMLIMKSQPKSKAEDIANPEACMISHDPWYTIYSTFCAFYIPLILMLVLYGRIFKAARFRIRKTVRKSEKVKCLT 246 HSP 2 Score: 83.1889 bits (204), Expect = 1.462e-16 Identity = 41/88 (46.59%), Postives = 55/88 (62.50%), Query Frame = 1
Query: 1603 RNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKILLGHY 1866
+ K+ RERK +TL II G FI+CWLPF I + FC + L D + WLGY NS LNP+IY F+ DF++AF+KI+ H+
Sbjct: 326 KRKLALARERKTVKTLGIIMGTFILCWLPFFIKALVMPFCPSCQMPVWLMDVIN-WLGYSNSLLNPIIYAYFNKDFQSAFKKIIKCHF 412
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009127.1 (pep scaffold:Pmarinus_7.0:GL478629:43196:44446:-1 gene:ENSPMAG00000008256.1 transcript:ENSPMAT00000009127.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 182.57 bits (462), Expect = 9.979e-52 Identity = 97/204 (47.55%), Postives = 137/204 (67.16%), Query Frame = 1
Query: 436 ITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTD-INYLHRRTSSRIILMIIGVWLISVIISVPSRF--HTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQ 1038
I++L L A+IL I GN V+AAI LERTL+NV+NYLI SLAV DL+V+ILV+P++A+ +V W LG +CD++ DVL CT+SILHL VIA+DRYWA+T+ I+Y+++RT R ++MI WL+ IS+P T + A+ +C I++ YT++S GAFY+P+ M V+Y RI+ AR RIR KK +
Sbjct: 38 ISSLCLTALILCAIFGNSCVIAAIALERTLQNVANYLIGSLAVTDLLVSILVLPMAALYQVLDRWTLGQVVCDIFIALDVLCCTSSILHLCVIALDRYWAITNPIDYVNKRTPRRAVIMISLTWLVGFSISIPPMLGWRTPEDRAD------PNACKISQDHGYTIYSTFGAFYIPLILMLVLYSRIFRAARFRIRKNVKKATE 235
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Sea Lamprey
Match: HTR1F (5-hydroxytryptamine receptor 1F [Source:HGNC Symbol;Acc:HGNC:5292]) HSP 1 Score: 169.474 bits (428), Expect = 1.306e-46 Identity = 92/192 (47.92%), Postives = 122/192 (63.54%), Query Frame = 1
Query: 484 NVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTD-INYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCII-NESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHCLS 1053
N V+AAI R L+ +NYLI SLAVADL+VA LVMP++A V+ W LG LCDLW DV CTASILHL IA+DR+WA+TD Y H+RT R LMI WL++ ISVP F R+ A+ CII ++ V YT++S GAFY+P+A + +Y RI+ A+ R+ Y++++ KQ LS
Sbjct: 65 NALVIAAISATRKLRQPANYLIGSLAVADLLVAALVMPVAAAYVVTGEWALGGALCDLWLSLDVTCCTASILHLCAIALDRFWAITDAAEYAHKRTPGRAALMIAASWLLAACISVPPLFWRRRDPAK-------PRCIIEHDHVLYTIYSTFGAFYVPLALLLALYCRIFRAAK-RL-YEKRESKQREKLS 247 HSP 2 Score: 85.8853 bits (211), Expect = 4.012e-18 Identity = 40/105 (38.10%), Postives = 64/105 (60.95%), Query Frame = 1
Query: 1540 RSQSSLSFKDNKFNAMNSASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKIL 1854
R S+ F + + ++ ++ RER+AA+TL +I G F++CWLPF I + C + + D L WLGY+NS +NP+IYT+F+ DF++AFRK++
Sbjct: 319 RPPRSVRFMSARLD-QRRPCLQERISGSRERRAAKTLGLILGAFVVCWLPFFIKELVVNLCKSCAVSPEVAD-LLTWLGYMNSLINPLIYTMFNEDFKSAFRKLV 421
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001357.1 (pep scaffold:Pmarinus_7.0:GL478256:17157:19157:1 gene:ENSPMAG00000001226.1 transcript:ENSPMAT00000001357.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 158.688 bits (400), Expect = 2.499e-43 Identity = 90/197 (45.69%), Postives = 131/197 (66.50%), Query Frame = 1
Query: 439 TALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTD-INYLHRRTSSRIILMIIGVWLISVIISVPS----RFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIR 1014
T+ LGA+I +I GN FV+AAI LER+L+ V+NYLI SLAV DL+V++LV+P++A+ +V W LG +CD + DVL CT+SILHL IA+DRYWA+TD ++Y+++RT R LMI W++ IS+P R R + + +C I++ + YT++S GAFY+P+ M V+Y +I+ AR RIR
Sbjct: 5 TSSALGALIACSIAGNAFVLAAIYLERSLQTVANYLIGSLAVTDLLVSVLVLPVAALYQVLGRWTLGQAVCDAFIALDVLCCTSSILHLCAIALDRYWAITDPVDYVNKRTPRRAALMIAITWVVGFSISIPPMLGWRQAEDRADPD--------ACNISQHLGYTIYSTFGAFYIPLVLMLVLYGKIFSAARFRIR 193
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008360.1 (pep scaffold:Pmarinus_7.0:GL477173:168532:170490:1 gene:ENSPMAG00000007563.1 transcript:ENSPMAT00000008360.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 130.568 bits (327), Expect = 1.319e-32 Identity = 76/201 (37.81%), Postives = 110/201 (54.73%), Query Frame = 1
Query: 460 IILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTD-INYLHRRTSSRIILMIIGVWLISVIISV---------PSRFHTHRN-----NAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRY 1017
IIL TI GN V A+ ++LK N ++SLA AD++VA LVMP S E+ W G C+++ DVL CT+SI+HL I++DRYW+VT + Y +RT R+ I+ VW+I+ +IS P+ H HR+ NA V +C +NE Y + S +F+ P M ++Y RIY A+ R R+
Sbjct: 43 IILVTIFGNSLVAIAVFTSKSLKAAQNLFLVSLAAADILVATLVMPFSLANELMGYWVFGSFWCEMYLALDVLFCTSSIVHLCAISLDRYWSVTQAVRYNMKRTPRRVKRAIVIVWVIAALISFPPLVGTGRPPANIHRHRHQGSGRNASSSPSSVLPTCKLNEETWYVLSSCTASFFTPCLIMLLVYARIYQVAKGRARH 243 HSP 2 Score: 69.3218 bits (168), Expect = 1.195e-12 Identity = 33/84 (39.29%), Postives = 43/84 (51.19%), Query Frame = 1
Query: 1603 RNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKIL 1854
R K+ RE++ LA++ G F+ CW PF + C W GY NS LNP+IYTVF+ DFR AF+ IL
Sbjct: 380 RRKLTAAREKRFTFVLAVVMGVFVACWFPFFFSYSLTKICEASCKPPEYLFKFFFWCGYCNSSLNPLIYTVFNQDFRRAFKNIL 463
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Sea Lamprey
Match: adra2c (adrenoceptor alpha 2C [Source:NCBI gene;Acc:266752]) HSP 1 Score: 130.183 bits (326), Expect = 1.400e-32 Identity = 70/210 (33.33%), Postives = 118/210 (56.19%), Query Frame = 1
Query: 412 RLSWIQFYITALFLGAIIL----WTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTD-INYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRK 1026
+L W + L L +++L T+ GN V+ A++ +LK N ++SLA AD++VA LV+P S E+ W+ G C+++ DVL CT+SI+HL I++DRYW+V+ + Y +RT RI +I+ VW I++ IS+P ++ N + + +C +N + Y + S +G+F+ P M ++Y RIY + R R+
Sbjct: 41 KLGWEYSVLAGLGLSSLVLILVFATVFGNCLVIIAVLTRPSLKAPQNLFLVSLATADILVATLVIPFSLFNELMGYWYFGRVWCEIYLALDVLFCTSSIVHLCAISLDRYWSVSQAVEYNIKRTPRRIKRIIVIVWFIAIAISLPPLISMNQKNRQQQEEVGRPNCELNTNTWYILGSCIGSFFAPCLIMVLVYARIYHLVKWRAAKLRR 250 HSP 2 Score: 90.1225 bits (222), Expect = 2.204e-19 Identity = 45/97 (46.39%), Postives = 55/97 (56.70%), Query Frame = 1
Query: 1588 NSASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCG--SALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKILLGHYHT 1872
N A R K+ Q RER+ L+++ G F+ICW PF A C+ E C LF W GY NS LNPVIYTVF+ DFR AF+KIL +H
Sbjct: 365 NKARERRKIAQARERRFTFVLSVMIGVFVICWFPFFFTYSLSALCSPESCAIPETLFKFF-FWFGYCNSCLNPVIYTVFNRDFRRAFKKILCMQFHA 460
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Nematostella
Match: EDO47619 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RLK3]) HSP 1 Score: 105.916 bits (263), Expect = 1.302e-25 Identity = 68/195 (34.87%), Postives = 110/195 (56.41%), Query Frame = 1
Query: 436 ITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPI-SAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTDINYLHRRTSS-RIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIR 1014
+ A F+ +I++T+IGNV V A+ L R L+ + NY ++SL+ AD++VA+L MP A++ S+ W G+EL W+C D+L TASI++L+ ++IDR+ A+T Y S + L I+ VWL ++ IS LR++ + Y + +F P+ M V+YLRIY+ AR ++R
Sbjct: 1 VAATFVAMLIVFTLIGNVLVCASFALFRELRTICNYFVVSLSAADILVALLAMPFWCALQVTSNMWMFGLELQLFWSCMDILCGTASIMNLMAVSIDRHIAITMPFYYETVMSPIKAKLTIMFVWLYAITISC-------------LRLVQWPG---KQGKVYMNIAAFASFLCPLTVMVVMYLRIYLVARYQVR 179 HSP 2 Score: 53.5286 bits (127), Expect = 6.917e-8 Identity = 29/75 (38.67%), Postives = 46/75 (61.33%), Query Frame = 1
Query: 1627 ERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCL--WLGYVNSGLNPVIYTVFSPDFRTAFR 1845
+ KAA+T+A++ G F+ CW PF + + +A P + +L + W+ Y+NS LNPVIYT + ++R AFR
Sbjct: 188 DVKAAKTIAVVIGVFVACWTPFFVIIICYA---HHPGFNVTKTTLNVVKWMEYLNSCLNPVIYTCLNRNYRRAFR 259
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Nematostella
Match: EDO35211 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SM55]) HSP 1 Score: 98.5969 bits (244), Expect = 1.186e-22 Identity = 67/193 (34.72%), Postives = 100/193 (51.81%), Query Frame = 1
Query: 451 LGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVT-DINYLHRRTSSRIILMIIGVWLISVIIS--------VPSRFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFAR 1002
L +I+ TI GN V AA L R L+ V+NY ++SLA+ADL+V + MP+ V E+ LW CFD+ + TASI++L VI++DR++A+T Y + T R L I+ VWL + +S +PSR + A++ S YT F +F++P+ M Y RI+ AR
Sbjct: 8 LALLIVGTIFGNSLVCAAFYLFRDLRTVTNYFVVSLAIADLLVGFVSMPLWFTYLVFQWPPQNSEIYALWLCFDIATATASIMNLAVISVDRFYAITLPFQYSQKITKKRACLAIVFVWLYAFAVSSSRAISFAIPSR----ESRAQF-------------SFGYTFFVATASFFVPLPVMIYCYTRIFSVAR 183 HSP 2 Score: 59.3066 bits (142), Expect = 1.500e-9 Identity = 33/79 (41.77%), Postives = 44/79 (55.70%), Query Frame = 1
Query: 1633 KAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCL-----WLGYVNSGLNPVIYTVFSPDFRTAFRKIL 1854
KAA+TLAI+ G F++CW P+ I + C P D L WL Y NS LNP+IYT + FR AF+++L
Sbjct: 229 KAAKTLAIVMGAFLLCWAPYIIALLLEVSC---PRCVPFQDKYTLAKAVKWLVYSNSALNPIIYTALNRAFRDAFKRVL 304
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Nematostella
Match: EDO47616 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RLJ6]) HSP 1 Score: 93.9745 bits (232), Expect = 2.009e-21 Identity = 65/198 (32.83%), Postives = 106/198 (53.54%), Query Frame = 1
Query: 436 ITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTW----WLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVT-DINYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIR 1014
+ +F+ ++L T+ GN V A+ L+ + NY I+SL+ +D+MVA+L MP + +++ LG W C D+L TASI++L ++ DR+ A+T +Y T R IL+I GVWL ++ +S LR++ I N+ SY VF + +F+LP+A M ++Y RIY+ A + R
Sbjct: 1 VAVIFVALLMLATLFGNFLVFASFYTFHDLRTICNYFIISLSASDIMVALLAMPFWLVLQLAPDMKYQTLLGRTEMSFWNCIDILCGTASIMNLAAVSADRHLAITAPYSYHELMTPVRAILVICGVWLYAITVSC-------------LRLV----SIPNKGYSYLVF--ITSFFLPLASMLIMYTRIYVVALRQAR 179 HSP 2 Score: 50.0618 bits (118), Expect = 1.239e-6 Identity = 28/82 (34.15%), Postives = 47/82 (57.32%), Query Frame = 1
Query: 1621 KRERKAARTLAIITGCFIICWLPFGINNVAHA----FCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKIL 1854
K + KAA+T+A++ G F ICWLPF + + A F + ++ ++ W Y+NS LNP+IY + +R AF+++
Sbjct: 188 KTDIKAAKTIAVVIGAFSICWLPFFVLIIGFAVRDDFITHK--SYQVYRAI-KWTHYLNSCLNPIIYCCLNRTYRRAFKRLF 266
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Nematostella
Match: EDO43835 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RXF3]) HSP 1 Score: 92.0485 bits (227), Expect = 4.179e-20 Identity = 68/222 (30.63%), Postives = 113/222 (50.90%), Query Frame = 1
Query: 460 IILWTIIGNVFVVAAIVLERTLKNV-SNYLILSLAVADLMVAILVMPISAIKEVSSTWWL-GIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTDINYLHRR----TSSRIILMIIGVWLISVIIS-VPSRFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHCL-----SNTDHKSCTDQTK 1089
+I TI+GN+ V AA+V+ L++V S+Y I+SLA++DL A MP ++S W G + C +WT +++ SIL+L+V++IDRY + D R T R ++ I+ +W S+ + VP H ++ + G+CI N + Y+V + F LPM M +Y +I+ A ++ R + + H + N + KS D K
Sbjct: 6 VITATIVGNLLVCAAVVVNANLRHVVSSYFIVSLAISDLATACFSMPFDMEYLITSGLWPRGEDFCIVWTTVYMIAIPTSILNLLVLSIDRYKTLKDPWDRFRESPFITKRRAVIAILVLWGYSLAFALVPITGVKHYPSS-----LYQGTCIFNMAPIYSVVGSFVNFVLPMLIMCCMYYKIFRIAHTKYRMPSRPKRDMHQVMQLPAMNEESKSPPDAEK 222 HSP 2 Score: 65.0846 bits (157), Expect = 2.805e-11 Identity = 39/133 (29.32%), Postives = 66/133 (49.62%), Query Frame = 1
Query: 1474 NFKNDLSFKGSNKSSELQFNDDR----SQSSLSFKDNKFNAMNSASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSAL---FDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKI 1851
N +N + KS++ N + K F +M +IR K + KAART+++I G F++CW PF + ++ C PC A+ + L +GY+NS +NP++++ + FR A+ KI
Sbjct: 229 NIRNSTKLRSRKKSAKKNNNSPEKAGLENAGFEEKPMNFGSMEDLTIRRKKYFVKNAKAARTISVIVGAFLLCWGPFVLFSIVMNIC-WMPCAMAVPYHVHHVFLLMGYINSMVNPLLFSYQNHQFRKAYWKI 360
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Nematostella
Match: EDO47699 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RLJ1]) HSP 1 Score: 89.7373 bits (221), Expect = 1.009e-19 Identity = 65/214 (30.37%), Postives = 111/214 (51.87%), Query Frame = 1
Query: 436 ITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVS-STWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAV-TDINYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHCLSNTDHKS 1071
I A F+ +I+ T+ GN V A+ R L+ + NY I+SL+V+D++VA++ MP ++S + W +L D W C D+L TASI++L+ ++ DR A+ T Y T R +++I VW + I S + W +Y + +F+LP++FM ++Y RIY+ A RY+ +++ +N+ TD K+
Sbjct: 32 IAATFVALLIVLTLGGNFIVCASFYTFRDLRTICNYFIISLSVSDILVALIAMPFWFTIQISDNKWRYSRKLKDYWDCMDILCGTASIMNLMAVSFDRQLAITTPFTYPKILTKRRALVIISFVWAYAATI---SGLRQLKAPPYW------------PFPNYLHLNATFSFFLPLSFMVMMYARIYLVA----RYQARRIGKNYA---TDIKA 223 HSP 2 Score: 63.1586 bits (152), Expect = 7.963e-11 Identity = 30/73 (41.10%), Postives = 45/73 (61.64%), Query Frame = 1
Query: 1633 KAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKI 1851
KAA+T+A++ G F CWLPF + + +A+ + S +L WL Y NS LNP+IYT + +R AFR++
Sbjct: 222 KAAKTIAVVVGVFAACWLPFFVIVLIYAWQGYDAGVSPQLFNLAKWLAYFNSCLNPIIYTCLNRTYRRAFRRL 294
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Medaka
Match: ENSORLT00000005282.2 (pep primary_assembly:ASM223467v1:9:8571029:8576106:1 gene:ENSORLG00000004220.2 transcript:ENSORLT00000005282.2 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 197.978 bits (502), Expect = 3.076e-56 Identity = 108/229 (47.16%), Postives = 151/229 (65.94%), Query Frame = 1
Query: 436 ITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTD-INYLHRRTSSRIILMIIGVWLISVIISVPS----RFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMK----QNHCLSNTD---HKSCTDQT 1086
IT+L LGA+IL +I GN VVAAI LER+L+NV+NYLI SLAV DLMV++LV+P++A+ +V + W LG E+CDL+ DVL CT+SILHL IA+DRYWA+TD I+Y+++RT R +L+I WLI IS+P R R N + +C+I++ YT++S GAFY+P+ M V+Y RI+ AR RIR KK++ + CL+ + HK Q+
Sbjct: 44 ITSLLLGALILCSIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQEICDLFISLDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPMRAVLLICATWLIGFSISIPPMLGWRSAEDRANPD--------ACMISQDPGYTIYSTFGAFYIPLILMLVLYGRIFRAARFRIRKTVKKIETAKVSDKCLAVSPAFFHKKSNGQS 264 HSP 2 Score: 83.9593 bits (206), Expect = 8.974e-17 Identity = 48/122 (39.34%), Postives = 65/122 (53.28%), Query Frame = 1
Query: 1504 SNKSSELQFNDDRSQSSLSFKDNKFNAMNSASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKILLGHYH 1869
SN + L + SS +++ N NS + R K+ RERK +TL II G FI CWLPF I + FC ++ WLGY NS LNP+IY F+ DF+ AF+KI+ +H
Sbjct: 302 SNSKTHLPLPNTPQSSSHGYEN--MNERNSGAKR-KLALSRERKTVKTLGIIMGTFIFCWLPFFIVALVLPFCPESCFMPDWLGAVINWLGYSNSLLNPIIYAYFNKDFQNAFKKIIKCKFH 420
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Medaka
Match: htr1ab (5-hydroxytryptamine (serotonin) receptor 1A b [Source:ZFIN;Acc:ZDB-GENE-090409-2]) HSP 1 Score: 180.259 bits (456), Expect = 5.706e-50 Identity = 95/204 (46.57%), Postives = 132/204 (64.71%), Query Frame = 1
Query: 436 ITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTD-INYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNG-SCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQN 1041
+T+ LGA+IL I GN VVAAIVLER+L+NV+NYLI SLAV DLMV++LV+P++A+ +V ++W LG CD++ DVL CT+SILHL IA+DRYWA+T+ I+Y+ +RT R ++I WL+ ISVP N C I + YT++S GAFY+P+ M V+Y RI+ AR RIR +K ++
Sbjct: 20 VTSFLLGALILCAIFGNACVVAAIVLERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNSWTLGQVPCDIFISLDVLCCTSSILHLCAIALDRYWAITEPIDYMKKRTPRRAAVLISVTWLVGFSISVPPMLVMRSQPGSMAEDRANPKQCKIRQDPWYTIYSTFGAFYIPLTLMLVLYGRIFKAARFRIRRTVRKTEKK 223 HSP 2 Score: 83.9593 bits (206), Expect = 8.094e-17 Identity = 39/88 (44.32%), Postives = 53/88 (60.23%), Query Frame = 1
Query: 1603 RNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKILLGHY 1866
+ K+ RERK +TL II G FI+CWLPF I + FC + + WLGY NS LNP+IY F+ DF++AF+KI+ H+
Sbjct: 313 KRKIALARERKTVKTLGIIMGTFILCWLPFFIVALVMPFCQESCYMPRWLEDVINWLGYSNSLLNPIIYAYFNKDFQSAFKKIIKCHF 400
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Medaka
Match: drd3 (dopamine receptor D3 [Source:NCBI gene;Acc:101163209]) HSP 1 Score: 180.644 bits (457), Expect = 1.419e-49 Identity = 144/484 (29.75%), Postives = 229/484 (47.31%), Query Frame = 1
Query: 442 ALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIEL-CDLWTCFDVLSCTASILHLVVIAIDRYWAVTDINYLHRRT---SSRIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIF---ARSRIRYKRKKMKQNHCLSNTDHKSCTDQTKPTENTGQCPCNKRKIDEISYILNCEHCKLESLVIQNQNRKEWFDKHMSLLEFADEGENDSLSIQSNFYATTFANVKFENVDHVANVNCVGENDRNKAETMSNHSQKKINQTTNWSPKLIFYNYKAKLLNFKNDLSFKGSNKSSEL-QFNDDRSQSSL-----SFKDNKFNAMNSASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKIL 1854
A+ +IL + GNV V A++ ER+L+ +NYL++SLAVADL+VA LVMP + EV WL L C+++ DV+ CTASIL+L I+IDRY AV + L+ T R+ MI VW+++ +S P F + + + I N + ++S++ +FYLP ++Y+RIY+F R RI + + + K ++ ++C + P K K D L + I+ Q+ + SLL + N + V +N +++ +C T + Q ++ Q + S N L + E+ + ++ R+ +SL S + +F +M++ RE+KA + LAI+ G F+ICWLPF + ++ + C T AL+ + WLGYVNS LNPVIYT F+ +FR AF KIL
Sbjct: 40 AMLYSLLILAIVFGNVLVCLAVLRERSLQTTTNYLVVSLAVADLLVASLVMPWAVYLEVVGGAWLFNRLYCNIFVTLDVMMCTASILNLCAISIDRYTAVV-MPVLYNTTHCSRKRVFAMIATVWVLAFAVSCPLLFGFNTTDDPMVCSISNP--------DFVIYSSVVSFYLPFIVTLLVYIRIYVFLRMRRKRIAFGQARGKVQPGSTHPSVETCLQEETP----------KAKQD------------LSPIRIKVQSVESSGTSKPSLLSGCLWRKRPKTGPAQN---SGLPPVDMQNYCSISHASC--------GRTEFDLEQGQVEQDASDS----------------NQLELPPIRMNCEVKELSNGRTHTSLRPISHSQNNPRFRSMHA----------REKKATQMLAIVLGVFLICWLPFFVTHILNTHCRTCQIPPALYGAFT-WLGYVNSALNPVIYTTFNIEFRRAFIKIL 454
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Medaka
Match: ENSORLT00000042787.1 (alpha-2B adrenergic receptor-like [Source:NCBI gene;Acc:101155866]) HSP 1 Score: 176.407 bits (446), Expect = 4.088e-48 Identity = 125/481 (25.99%), Postives = 224/481 (46.57%), Query Frame = 1
Query: 442 ALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVT-DINYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIR---YKRKKMKQNHCLSNTDHKSCTDQTKPTENTGQCPCNKRKIDEISYILNCEHCKLESLVIQNQNRKEWFDKHMSLLEFADEGENDSLSIQSNFYATTFANV-----KFENVDHVANVNCVGENDRNKAETMSNHSQKKINQTTNWSPKLIFYNYKAKLLNFKNDLSFKGSNKSSELQFNDDRSQSSLSFKDNKFNAMNSASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKILL 1857
++ + ++++ TI+GN+ V+ A+++ R+L+ N ++SLA AD++VA++V+P S E+ W C++ DVL CTASI+HL IA+DRY +++ ++Y R+ RI I+ VWLI+ ++S P + + V G C ++ Y ++S +G+F+ P M ++Y+RIY A+ + ++++ +T+ KS ++++ ++ GQ SL + + +W DK + E EG ++T N K E D V ++++T ++ SPK ++ +KN + K S+ + L + ++Q + R+K RE++ LA++ G F++CW PF + A C + W GY NS LNP+IYT+F+ DFRTAF++IL
Sbjct: 31 SIVMTSMMILTIVGNILVIIAVLMSRSLRGPQNLFLVSLAAADILVALIVVPFSMAYELLGCWVFSSIWCEIHKALDVLFCTASIVHLCAIALDRYLSISRPVSYGTTRSRRRIKSAIVMVWLIAAVVSFPPLLYLDTKDK------VKGKCEPDDKPWYILYSTIGSFFAPCVIMILVYIRIYQIAKRHMHCPPGEKRRSFYGAATDDTEMKSLPEESQ--KDVGQ---------------RAPAAPELSLTTVHTDCAQWNDKKPA--ESPTEGP--------PLFSTAVPNAARDLPKAEGEDAV-------HTSSSESDTELQSIEEGDRAGGGGSPKA---QVQSPTCRYKN--TIKTSSGTKLLPEDTAKTQ-------------ETPISRHKAMINREKRFTLVLAVVMGVFVVCWFPFFFSYSLKAVCPEKYQVPDPLFRFFFWSGYCNSCLNPIIYTIFNRDFRTAFKRILF 453
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Medaka
Match: adra2b (alpha-2B adrenergic receptor [Source:NCBI gene;Acc:101157221]) HSP 1 Score: 174.866 bits (442), Expect = 5.080e-47 Identity = 124/481 (25.78%), Postives = 224/481 (46.57%), Query Frame = 1
Query: 460 IILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTDINYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHCLSNTDHKSC----TDQTKPTENTGQCPCNKRK--IDEISYILNCEHCKLESLVIQNQNRKEWFD--------KHMSLLEFADEGENDSLSIQSNFYATTFANVKFENVDHVANVNCVGENDRNKAETMSNHSQKKINQTTNWSPKLIFYNYKAKLLNFKNDLSFKGSNKSSELQFNDDRSQSSLSFKDNKFNAMNSASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPC--GSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKIL 1854
++++TI+GN+ V+ A++ R+L+ N ++SLA AD++VA L++P S E+ W+ C+++ DVL CT+SI+HL I++DRY +++ + Y +RT RI I+ VWLIS +IS P +++ + C +N+ Y ++S +G+F+ P M ++Y+RIY A+ R R + +++ S T + + E+ P K+ + + + +S + N ++ +E + G ++ + T K + N N G++ ++ + + + + SP + A +FK L+ ++K + L + + +K + A+ R + + +R +I G F++CW PF + A C E C LF + W+GY NS LNPVIYT+F+ DFR AF+KIL
Sbjct: 54 MVIFTIVGNIMVIIAVLTSRSLRGPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFKSLWCEIYLALDVLFCTSSIVHLCAISLDRYLSISRVTYGRQRTPRRIKAAIVVVWLISSVISFPPLLSLNKSESNKSGNEKGPQCQLNDERWYILYSTVGSFFAPCLIMILVYVRIYQIAKQRTRCPPGEPRKDGIGSATPSQPPRHLKANGKDEDEDDSTPPSTKKTSNVRPPTLAVTPSPSLGDSQISPNPTANNLLQPPSPSSALSPVTSVETSPHGPSNPFPAPQSGPMTKEEAKKAKRQKAKKNDNNNGDSSSTDSDMEHSQGGGRGSTSMPGSPAGGGIHSPA---SFKRILA---TSKGARL----------VPGRKSKPESNPGAARRKAMVNREKRFTFVLAVVI-GVFVLCWFPFFFSYSLQAVC-PETCNVPKPLF-TFFFWIGYCNSSLNPVIYTIFNKDFRNAFKKIL 515
BLAST of 5-hydroxytryptamine receptor vs. Planmine SMEST
Match: SMESG000019254.1 (SMESG000019254.1) HSP 1 Score: 1058.51 bits (2736), Expect = 0.000e+0 Identity = 512/513 (99.81%), Postives = 512/513 (99.81%), Query Frame = 1
Query: 352 MVLFYEYENVTESQIARFSPRLSWIQFYITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTDINYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHCLSNTDHKSCTDQTKPTENTGQCPCNKRKIDEISYILNCEHCKLESLVIQNQNRKEWFDKHMSLLEFADEGENDSLSIQSNFYATTFANVKFENVDHVANVNCVGENDRNKAETMSNHSQKKINQTTNWSPKLIFYNYKAKLLNFKNDLSFKGSNKSSELQFNDDRSQSSLSFKDNKFNAMNSASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKILLGHYHTRRCLKC 1890
MVLFYEYENVTESQIARFSPRLSWIQFYITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTDINYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHCLSNTDHKSCTDQTKPTENTGQCPCNKRKIDEISYILNCEHCKLESLVIQNQNRKEWFDKHMSLLEFADEGENDSLSIQSNFYATTFANVKFENVDHVANVNCVGENDRNKAETMSNHSQKK NQTTNWSPKLIFYNYKAKLLNFKNDLSFKGSNKSSELQFNDDRSQSSLSFKDNKFNAMNSASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKILLGHYHTRRCLKC
Sbjct: 1 MVLFYEYENVTESQIARFSPRLSWIQFYITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTDINYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHCLSNTDHKSCTDQTKPTENTGQCPCNKRKIDEISYILNCEHCKLESLVIQNQNRKEWFDKHMSLLEFADEGENDSLSIQSNFYATTFANVKFENVDHVANVNCVGENDRNKAETMSNHSQKKTNQTTNWSPKLIFYNYKAKLLNFKNDLSFKGSNKSSELQFNDDRSQSSLSFKDNKFNAMNSASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKILLGHYHTRRCLKC 513
BLAST of 5-hydroxytryptamine receptor vs. Planmine SMEST
Match: SMESG000047237.1 (SMESG000047237.1) HSP 1 Score: 763.451 bits (1970), Expect = 0.000e+0 Identity = 365/368 (99.18%), Postives = 366/368 (99.46%), Query Frame = 1
Query: 787 MIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHCLSNTDHKSCTDQTKPTENTGQCPCNKRKIDEISYILNCEHCKLESLVIQNQNRKEWFDKHMSLLEFADEGENDSLSIQSNFYATTFANVKFENVDHVANVNCVGENDRNKAETMSNHSQKKINQTTNWSPKLIFYNYKAKLLNFKNDLSFKGSNKSSELQFNDDRSQSSLSFKDNKFNAMNSASIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKILLGHYHTRRCLKC 1890
MIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHCLSNTDHKSCTDQTKPTENTGQCPCNKRKIDEISYILNCEHCKLESLVIQNQNRKEWFDKHMSLLEFADEGENDSLSIQSNFYATTFANVKFENVDHVANVNCVGENDRNKAETMSN+SQKK NQTTNWSPKLIFYNYKAKLLNFKNDLSFKGSNKSSELQFNDDRSQSSLSFKDNKFNAMNS SIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKILLGHYHTRRCLKC
Sbjct: 1 MIIGVWLISVIISVPSRFHTHRNNAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHCLSNTDHKSCTDQTKPTENTGQCPCNKRKIDEISYILNCEHCKLESLVIQNQNRKEWFDKHMSLLEFADEGENDSLSIQSNFYATTFANVKFENVDHVANVNCVGENDRNKAETMSNYSQKKTNQTTNWSPKLIFYNYKAKLLNFKNDLSFKGSNKSSELQFNDDRSQSSLSFKDNKFNAMNSVSIRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKILLGHYHTRRCLKC 368
BLAST of 5-hydroxytryptamine receptor vs. Planmine SMEST
Match: SMESG000008878.1 (SMESG000008878.1) HSP 1 Score: 355.91 bits (912), Expect = 1.583e-115 Identity = 215/511 (42.07%), Postives = 293/511 (57.34%), Query Frame = 1
Query: 394 IARFSPRLSWIQFYITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTDINYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRN-NAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYK--RKKMKQNHCLSNTDHKSCTDQT----KPTENTGQCPCNKRKIDEISYILNCEHCKLESLVIQNQNRKEWFDKHMSLLEFADEGENDSLSIQSNFYATTFANVKFENVDHVANVNCVGENDRNKAETMSNHSQKKINQTTNWSPKLIFYNYKAKLLNFKNDLS----FKGSNKSSELQFNDDRSQSSLSFKDNKFNAMNSAS-----IRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKILLGHYHTRR 1878
++ F P+ W YIT+ L +IL T+IGN FV+AAI+LE+ L NVSNYLI+SLAVADLMVA LVM +S E+S W+LG+E+CDLW CFDVL C+ASILHLV IAIDRY AVT +Y+ RT+ RI +MI +WL+S++ISVP+RFH +RN E RV+ +G C+IN+ + +TVFS GAFYLPM F+ IY RIY AR+RIR + RK+++ H +S + CT +T ++ +C N K+ +L +N F D+ N S+++ + +T + + + + + + N+R S++ IN + K K+K L +L+ KG K+ R +++S +++ + M S S R K+EQKRERKA RTLAIITGCFI+CW PF I FC + L S LWLGY NS LNPVIYT+FSPDFR AF KIL G Y R
Sbjct: 18 VSTFRPKYGWTHIYITSGVLVVLILCTVIGNSFVIAAILLEKNLLNVSNYLIISLAVADLMVASLVMSLSVFHEISEAWFLGLEICDLWVCFDVLCCSASILHLVAIAIDRYMAVTKPDYVRTRTAKRIYIMIAIIWLLSIMISVPTRFHLNRNYTKEMQRVVYDGKCLINDEIGFTVFSTFGAFYLPMFFIIGIYTRIYQVARARIRRQAFRKRLRSQHHVSKRS-QPCTCKTGFINSKSDTHIECGNNGEKV-------------CHNLDEKNSLNSCNNSSDSDSCCFIDKMNNSSIALNCH-QDSTISYMLTDTISMSDDRKILNSNNRRLLN--SDYKTIHINHLRKYILK------KSKALKVNENLNSVSVIKGPTKT--------RLMNNISTHEHRPSRMMSQSERMEYKRQKLEQKRERKAVRTLAIITGCFIVCWQPFFIQATIVPFCGKKCQLPPLLSSFVLWLGYCNSLLNPVIYTIFSPDFRDAFHKILFGRYLVNR 497
BLAST of 5-hydroxytryptamine receptor vs. Planmine SMEST
Match: SMESG000008878.1 (SMESG000008878.1) HSP 1 Score: 356.295 bits (913), Expect = 1.778e-115 Identity = 215/511 (42.07%), Postives = 293/511 (57.34%), Query Frame = 1
Query: 394 IARFSPRLSWIQFYITALFLGAIILWTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTDINYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRN-NAEWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYK--RKKMKQNHCLSNTDHKSCTDQT----KPTENTGQCPCNKRKIDEISYILNCEHCKLESLVIQNQNRKEWFDKHMSLLEFADEGENDSLSIQSNFYATTFANVKFENVDHVANVNCVGENDRNKAETMSNHSQKKINQTTNWSPKLIFYNYKAKLLNFKNDLS----FKGSNKSSELQFNDDRSQSSLSFKDNKFNAMNSAS-----IRNKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCGSALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKILLGHYHTRR 1878
++ F P+ W YIT+ L +IL T+IGN FV+AAI+LE+ L NVSNYLI+SLAVADLMVA LVM +S E+S W+LG+E+CDLW CFDVL C+ASILHLV IAIDRY AVT +Y+ RT+ RI +MI +WL+S++ISVP+RFH +RN E RV+ +G C+IN+ + +TVFS GAFYLPM F+ IY RIY AR+RIR + RK+++ H +S + CT +T ++ +C N K+ +L +N F D+ N S+++ + +T + + + + + + N+R S++ IN + K K+K L +L+ KG K+ R +++S +++ + M S S R K+EQKRERKA RTLAIITGCFI+CW PF I FC + L S LWLGY NS LNPVIYT+FSPDFR AF KIL G Y R
Sbjct: 32 VSTFRPKYGWTHIYITSGVLVVLILCTVIGNSFVIAAILLEKNLLNVSNYLIISLAVADLMVASLVMSLSVFHEISEAWFLGLEICDLWVCFDVLCCSASILHLVAIAIDRYMAVTKPDYVRTRTAKRIYIMIAIIWLLSIMISVPTRFHLNRNYTKEMQRVVYDGKCLINDEIGFTVFSTFGAFYLPMFFIIGIYTRIYQVARARIRRQAFRKRLRSQHHVSKRS-QPCTCKTGFINSKSDTHIECGNNGEKV-------------CHNLDEKNSLNSCNNSSDSDSCCFIDKMNNSSIALNCH-QDSTISYMLTDTISMSDDRKILNSNNRRLLN--SDYKTIHINHLRKYILK------KSKALKVNENLNSVSVIKGPTKT--------RLMNNISTHEHRPSRMMSQSERMEYKRQKLEQKRERKAVRTLAIITGCFIVCWQPFFIQATIVPFCGKKCQLPPLLSSFVLWLGYCNSLLNPVIYTIFSPDFRDAFHKILFGRYLVNR 511
BLAST of 5-hydroxytryptamine receptor vs. Planmine SMEST
Match: SMESG000016680.1 (SMESG000016680.1) HSP 1 Score: 313.538 bits (802), Expect = 1.352e-98 Identity = 195/539 (36.18%), Postives = 292/539 (54.17%), Query Frame = 1
Query: 469 WTIIGNVFVVAAIVLERTLKNVSNYLILSLAVADLMVAILVMPISAIKEVSSTWWLGIELCDLWTCFDVLSCTASILHLVVIAIDRYWAVTDINYLHRRTSSRIILMIIGVWLISVIISVPSRFHTHRNNA-EWLRVIVNGSCIINESVSYTVFSNLGAFYLPMAFMSVIYLRIYIFARSRIRYKRKKMKQNHCLSNTDHKSCTDQTKPTENTGQCPCNKRKI-----DEISYILNCEHCKLESLVIQNQNRKEWFDKHMSLLEFAD-EGENDS-------------------------------------LSIQSNFYATT--------------FANVKFENVDHVANVNCVGENDRNKAETMSNHSQKKINQTTNWSPKLIFYNYKAKLLNFKNDLSF---------------KGSNKSSELQFNDDRSQSSLSFKDNKFNAMNSASIR-NKVEQKRERKAARTLAIITGCFIICWLPFGINNVAHAFCNTEPCG-SALFDSLCLWLGYVNSGLNPVIYTVFSPDFRTAFRKILLG 1860
WTI GNV V+ IV E +KN SN+LI SLAV DL VA+ VMP+SAIKEVS WWLG+ELCD+W DVL+CTASI HLVVIAIDRY ++T + Y R++ MI W+ + ++S+PSRF+ RNN E + V NG+C+INE SYT+ +N +F P+ M ++Y +I+IF + + + RK +K + S+ + +++T P + +I D+ I+ + ES V ++ + +W ++ S ++AD E EN S + S+ Y T+ +K++N D + + N ++++ + +++S+K + T +WSPKL F+ Y+ + KN +F K N S+ F ++Q S S DN F ++ ++R ++ QKRE K RTL IITG FIICWLPF INN+ A+ ++P + + DS+ LW GYVNSGLNP+IYT+FS +F+ AF+KIL G
Sbjct: 14 WTIAGNVLVMVTIVTELNIKNSSNHLIFSLAVTDLFVAVAVMPLSAIKEVSIKWWLGLELCDIWIFTDVLTCTASIFHLVVIAIDRYLSITKLTYNRNRSTVSTTAMITSSWIAAALVSIPSRFYLQRNNTVERITVNYNGTCLINEGNSYTILANFLSFCFPLILMGIVYFKIFIFIKKQTK-NRKAIKNSVIGSDALSTTFASDICYSKSTAS-PFPQSEIWSSIYDDSKIII--DENSFESTVTESLEKTKWVNEECSNFQYADEEDENQSKSNNNLSENVTNKYLYCLDKSSTESFPMSSLYLNPLTMKTYSDIYTTSNLAKTETMSTIEGEIFPLKYQNKDILKSPN----SNKSIIKPSTSNSRKLKSPTLSWSPKLTFFPYRQSKPSIKNGFNFVEANYSLLSSISSPLKNHNHSNNEHF---QTQISDSLNDNSFASL---AVRVKRINQKREYKVVRTLFIITGLFIICWLPFAINNLLRAYVISDPSEINRIMDSIFLWFGYVNSGLNPIIYTIFSTEFQVAFKKILFG 538 The following BLAST results are available for this feature:
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of 5-hydroxytryptamine receptor vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of 5-hydroxytryptamine receptor vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of 5-hydroxytryptamine receptor vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of 5-hydroxytryptamine receptor vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30033325 ID=SMED30033325|Name=5-hydroxytryptamine receptor|organism=Schmidtea mediterranea sexual|type=transcript|length=2019bpback to top protein sequence of SMED30033325-orf-1 >SMED30033325-orf-1 ID=SMED30033325-orf-1|Name=SMED30033325-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=514bp MVLFYEYENVTESQIARFSPRLSWIQFYITALFLGAIILWTIIGNVFVVAback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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