Retinoid isomerohydrolase

Overview
NameRetinoid isomerohydrolase
Smed IDSMED30033232
Length (bp)1362
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Retinoid isomerohydrolase (SMED30033232) t-SNE clustered cells

Violin plots show distribution of expression levels for Retinoid isomerohydrolase (SMED30033232) in cells (dots) of each of the 12 neoblast clusters.

 

back to top

 

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Retinoid isomerohydrolase (SMED30033232) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Retinoid isomerohydrolase (SMED30033232) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

back to top

 

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

back to top
Anatomical Expression

PAGE et. al., 2020



SMED30033232

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 7

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
head regionSMED30033232SMESG000054001.1 SmedASXL_013498SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
pharynxSMED30033232SMESG000054001.1 dd_Smed_v4_13185_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30033232SMESG000054001.1 dd_Smed_v4_13185_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30033232SMESG000054001.1 dd_Smed_v4_13185_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30033232SMESG000054001.1 dd_Smed_v4_13185_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30033232SMESG000054001.1 dd_Smed_v6_13185_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
epidermisSMED30033232SMESG000054001.1 dd_Smed_v4_13185_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Retinoid isomerohydrolase vs. Ensembl Human
Match: FAM81A (family with sequence similarity 81 member A [Source:HGNC Symbol;Acc:HGNC:28379])

HSP 1 Score: 82.8037 bits (203), Expect = 1.165e-16
Identity = 92/354 (25.99%), Postives = 187/354 (52.82%), Query Frame = 3 
Query:  153 IIPYNRMNSGINSDKIGEFEFRLDVQERTTQQLIDKAVQIKQNLIENLNFTQGTWMEEKEARELLQEHVRTITAVIRQMNXXXXXXXXXXXXXXXXNSGTXXXXXXXXXXXXXXXXXXXXXXXXCDSVSAKLANDIRLLGESVKAIGMDLGQTSNKTNEKLQNIELKNQDLFNKIERLNSDSNTNIRISVDETNKQLFELDNRTKFIFDDLRHQIKSFQMQSEVEKEKFETRMLTAFDKSFTSFEARLTKLEENMNSD-RHLKVILDRLENFENDYKNFRKDRIIFEKDLEKRMTDHSDRLYRQQIDDLSRFKREVRDSFAAVYETVNMMQSMFEKKQKLIEDNLRKEMGQLRK 1211
            + PY+ ++       + + E R+   E+TT  L++ A +IK +++ +L   Q     ++ AR  L+EH+R ITA+++Q+N++I+ ++  I+ ++  + GT++ ++ +E  Q+S + ++RGR+ RCD+  A+L+ + +   E ++ +  +          K+++ E +   L N+++   S+ +T +++S  ++N QL  LD + K   ++L +QI S +   + E+E+ E  +L   D+     +      E +M      +   LD++E  E   K F   R   E   E++M     +L  Q   ++   K EV   F AVYE++  ++ + E K KL  D L+K++  ++K
Sbjct:   21 MAPYSSVSL------VEQLEDRILCHEKTTAALVEHAFRIKDDIVNSLQKMQNKGGGDRLARLFLEEHIRNITAIVKQLNRDIEVLQEQIRARDNISYGTNSALKTLEMRQLSGLGDLRGRVARCDASIARLSAEHKTTYEGLQHLNKEQQAAKLILETKIKDAEGQISQLLNRVDLSISEQSTKLKMSHRDSNHQLQLLDTKFKGTVEELSNQILSARSWLQQEQERIEKELLQKIDQLSLIVKENSGASERDMEKKLSQMSARLDKIE--EGQKKTFDGQRTRQE---EEKMHGRITKLELQMNQNIKEMKAEVNAGFTAVYESIGSLRQVLEAKMKLDRDQLQKQIQLMQK 363
[Close]
BLAST of Retinoid isomerohydrolase vs. Ensembl Human
Match: FAM81B (family with sequence similarity 81 member B [Source:HGNC Symbol;Acc:HGNC:26335])

HSP 1 Score: 71.633 bits (174), Expect = 8.611e-13
Identity = 78/340 (22.94%), Postives = 185/340 (54.41%), Query Frame = 3 
Query:  201 GEFEFRLDVQERTTQQLIDKAVQIKQNLIENLNFTQGTWMEEKEARELLQEHVRTITAVIRQMNXXXXXXXXXXXXXXXXNSGTXXXXXXXXXXXXXXXXXXXXXXXXCDSVSAKLANDIRLLGESVKAIGMDLGQTSNKTNEKLQNIELKNQDLFNKIERLNSDSNTNIRISVDETNKQLFELDNRTKFIFDDLRHQIKSFQMQSEVEKEKFETRMLTAFDKSFTSFEARLTKLEENMNSDRHLKVILDRLENFENDYKNFRKDRIIFEKDLEKRMTDHSDRLYRQQIDDLSRFKREVRDSFAAVYETVNMMQSMFEKKQKLIEDNLRKEMGQLRKMVV 1220
            G+ E RL+ Q RT   L+++A +IK+++   L  T G   EE  AR+LL+ H++TIT++++++++ I+ +E  I+ ++   +GT+  + +I    +  + ++RGR+ RCDS   KL+ DI L  +  + I   + +         +N+++K   L  KIE  +S+  +N+++   +   ++  L+ +   +  +L  ++++ +  +E +  K+    L   ++     + +L K E  M  +  L  +  ++ENF N  K  ++ ++   K +E +++   +++ +Q   +L   + E +  F +++++++ +Q + + K  L +  ++K++ +L++ +V
Sbjct:  112 GQLEDRLNNQARTIAFLLEQAFRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSIVKKLSQNIEILEDQIRARDQAATGTNFAVHEINIKHLQGVGDLRGRVARCDSSIVKLSGDIHLFRQEHRQIEKAIQEFVPALETLSKNLDMKVMQLLGKIETASSEQTSNLKMVQGDYRHEMNLLEFKFHSLSSNLYEEVENNKKWTENQFLKYRKDHLGHINECLKVLQEKLEKSENKM--EEKLLQLSSKVENFINTQK--QETQLSKVKHMENKLSKKMEQMEKQIWGELETMQNEYQSGFKSIHDSLSSLQQIQKTKMDLEKYKVQKDLKKLQRKIV 447
[Close]
BLAST of Retinoid isomerohydrolase vs. Ensembl Human
Match: FAM81B (family with sequence similarity 81 member B [Source:HGNC Symbol;Acc:HGNC:26335])

HSP 1 Score: 49.2914 bits (116), Expect = 9.149e-7
Identity = 24/64 (37.50%), Postives = 44/64 (68.75%), Query Frame = 3 
Query:  201 GEFEFRLDVQERTTQQLIDKAVQIKQNLIENLNFTQGTWMEEKEARELLQEHVRTITAVIRQMN 392
            G+ E RL+ Q RT   L+++A +IK+++   L  T G   EE  AR+LL+ H++TIT+++++++
Sbjct:   58 GQLEDRLNNQARTIAFLLEQAFRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSIVKKLS 121
[Close]
BLAST of Retinoid isomerohydrolase vs. Ensembl Human
Match: FAM81B (family with sequence similarity 81 member B [Source:HGNC Symbol;Acc:HGNC:26335])

HSP 1 Score: 49.2914 bits (116), Expect = 3.004e-6
Identity = 24/64 (37.50%), Postives = 44/64 (68.75%), Query Frame = 3 
Query:  201 GEFEFRLDVQERTTQQLIDKAVQIKQNLIENLNFTQGTWMEEKEARELLQEHVRTITAVIRQMN 392
            G+ E RL+ Q RT   L+++A +IK+++   L  T G   EE  AR+LL+ H++TIT+++++++
Sbjct:   62 GQLEDRLNNQARTIAFLLEQAFRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSIVKKLS 125
[Close]
BLAST of Retinoid isomerohydrolase vs. Ensembl Human
Match: FAM81A (family with sequence similarity 81 member A [Source:HGNC Symbol;Acc:HGNC:28379])

HSP 1 Score: 46.595 bits (109), Expect = 6.159e-6
Identity = 22/65 (33.85%), Postives = 41/65 (63.08%), Query Frame = 3 
Query:  198 IGEFEFRLDVQERTTQQLIDKAVQIKQNLIENLNFTQGTWMEEKEARELLQEHVRTITAVIRQMN 392
            + + E R+   E+TT  L++ A +IK +++ +L   Q     ++ AR  L+EH+R ITA+++Q+N
Sbjct:   30 VEQLEDRILCHEKTTAALVEHAFRIKDDIVNSLQKMQNKGGGDRLARLFLEEHIRNITAIVKQLN 94
[Close]
BLAST of Retinoid isomerohydrolase vs. Ensembl Zebrafish
Match: fam81b (family with sequence similarity 81 member B [Source:ZFIN;Acc:ZDB-GENE-130530-586])

HSP 1 Score: 56.6102 bits (135), Expect = 3.566e-9
Identity = 46/152 (30.26%), Postives = 99/152 (65.13%), Query Frame = 3 
Query:  198 IGEFEFRLDVQERTTQQLIDKAVQIKQNLIENLNFTQGTWMEEKEARELLQEHVRTITAVIRQMNXXXXXXXXXXXXXXXXNSGTXXXXXXXXXXXXXXXXXXXXXXXXCDSVSAKLANDIRLLGESVKAIGMDLGQTSNKTNEKLQNIELK 653
            IG  E R+  QE T   L++KA++I+ +++  L+  QG+ + E  AR+LL+ H++ IT +++Q++K+I+ +E+ I E++   +GT+  ++ +++  +  I ++RGR+ RCD+  AKL++D+    + +  +  ++ +  +K   K++++ELK
Sbjct:    3 IGYMERRVTNQEHTLNSLLEKAMKIRDDVVTGLHAAQGSALMESSARKLLENHIQIITHIVKQLSKDIQVLEAQIMERDNLAAGTTFAVKSLDHKNMMGIGDLRGRVARCDASIAKLSSDVGAEQQDILKLKQEVNELHSKLELKMKDMELK 154
[Close]
BLAST of Retinoid isomerohydrolase vs. Ensembl Xenopus
Match: FAM81B (family with sequence similarity 81 member B [Source:NCBI gene;Acc:100498576])

HSP 1 Score: 58.9214 bits (141), Expect = 7.291e-9
Identity = 83/359 (23.12%), Postives = 187/359 (52.09%), Query Frame = 3 
Query:  177 SGINSDKIGEFEFRLDVQERTTQQLIDKAVQIKQNLIENLNFTQGT-WMEEKEARELLQEHVRTITAVIRQMNXXXXXXXXXXXXXXXXNSGTXXXXXXXXXXXXXXXXXXXXXXXXCDSVSAKLANDIRLLGESVKAIGMDLGQTSNKTNEKLQNIELKNQDLFNKIERLNSDSNTNIRISVDETNKQLFELDNRTKFIFDDLRHQIKSFQMQSEVEKEKFETRMLTAFDKSFTSFEARL----TKLEENMNSDRHLKVILD------RLENFENDYKNFRKDRIIFEKDLEKRMTDHSDRLYRQQIDDLSRFKREVRDSFAAVYETVNMMQSMFEKKQKLIEDNLRKEMGQLRKMVV 1220
              I+ +++   E RL  QE+TT  L+++A ++K + + +L    G+ W  +  A+ LL+ H++T+  +++Q++K+I+T+E+ I++++  ++GTS  ++ ++   +  I ++RGR+ RCD+  AKL+ D+      ++A   ++   +      ++  + K   L  K+E   S+ N  ++ +  E + ++  LD +   + +D++ QI++ +  +E + +K       + ++   + + ++     +L++N+   +HL + +D      RLE   N  K+        E  +  RM      ++    D+L   K E R  F ++ E++N +Q + E K  L    + +++ QLR+ +V
Sbjct:    7 PAIHMNRVDGLEGRLFNQEKTTNILLNQAFKLKDD-VSSLRGLHGSHW--DTVAQRLLENHMQTMAQIVKQLSKDIETLENQIRDRDQVSTGTSYAVQNLDKRHLYGIGDLRGRVARCDASIAKLSGDLANTKHELQAQEKEIRSINASLETHMKESDFKVMQLLGKMEASISEQNNKVKSAQGEQHHEIQLLDFKLGGLLNDIQGQIQNHRRWTESQIQKSSQEQAHSLEQLLGAIQQKMDISEKRLQDNI---QHLTIKVDKTVETQRLETKLNKLKH-------AEDKINARMNAIETEIW----DELENMKSEYRAGFQSIQESLNSLQQIQETKVNLETKKVHRDIKQLRRKIV 348
[Close]
BLAST of Retinoid isomerohydrolase vs. Ensembl Mouse
Match: Fam81a (family with sequence similarity 81, member A [Source:MGI Symbol;Acc:MGI:1924136])

HSP 1 Score: 78.1814 bits (191), Expect = 2.881e-15
Identity = 86/343 (25.07%), Postives = 181/343 (52.77%), Query Frame = 3 
Query:  153 IIPYNRMNSGINSDKIGEFEFRLDVQERTTQQLIDKAVQIKQNLIENLNFTQGTWMEEKEARELLQEHVRTITAVIRQMNXXXXXXXXXXXXXXXXNSGTXXXXXXXXXXXXXXXXXXXXXXXXCDSVSAKLANDIRLLGESVKAIGMDLGQTSNKTNEKLQNIELKNQDLFNKIERLNSDSNTNIRISVDETNKQLFELDNRTKFIFDDLRHQIKSFQMQSEVEKEKFETRMLTAFDKSFTSFEARLTKLEENMNSDRHLKVILDRLENFENDYK-NFRKDRIIFEKDLEKRMTDHSDRLYRQQIDDLSRFKREVRDSFAAVYETVNMMQSMFEKKQKLIED 1178
            + PY+ ++       + + E R+   E+TT  L++ A +IK +++ +L   Q     ++ AR  L+EH+R ITA+++Q+N++I+ ++  I+ ++  + GT++ ++ +E  Q+S + ++RGR+ RCD+  A+L+ + +   E ++ +  +          K+++ E +   L ++++   S+ +T +++S  ++N QL  LD + K   ++L +QI S +   + E+E+ E  +L   D    S   +        + ++ L  +  RL+  E   K N    R   E+ +  R++    +L  Q  +D+   K EV   F+A+YE++  ++ + E K KL  D
Sbjct:   18 MAPYSSVSL------VEQLEDRILCHEKTTAALVEHAFRIKDDIVSSLQKMQNKGGGDRLARLFLEEHIRNITAIVKQLNRDIEVLQEQIRARDNISYGTNSALKTLEMRQLSGLGDLRGRVARCDASIARLSAEHKSTYEGLQHLNKEQQAAKLILETKIKDAEGQISQLLSRVDLSISEQSTKLKMSHRDSNHQLQLLDTKFKGTVEELSNQILSARSWLQQEQERIEKELLQKID--HLSLIVKENSGANERDVEKKLSQMSARLDKIEESQKRNAEGQRKPDEEKVHGRIS----KLELQMTEDMKEMKAEVNAGFSAIYESIGSLRQVLEAKMKLDRD 348
[Close]
BLAST of Retinoid isomerohydrolase vs. Ensembl Mouse
Match: Fam81b (family with sequence similarity 81, member B [Source:MGI Symbol;Acc:MGI:2685122])

HSP 1 Score: 78.5666 bits (192), Expect = 3.391e-15
Identity = 83/355 (23.38%), Postives = 193/355 (54.37%), Query Frame = 3 
Query:  177 SGINSDKIGEFEFRLDVQERTTQQLIDKAVQIKQNLIENLNFTQGTWMEEKEARELLQEHVRTITAVIRQMNXXXXXXXXXXXXXXXXNSGTXXXXXXXXXXXXXXXXXXXXXXXXCDSVSAKLANDIRLLGESVKAIGMDLGQTSNKTNEKLQNIELKNQDLFNKIERLNSDSNTNIRISVDETNKQL----FELDNRTKFIFDDLRHQIKSFQMQSEVEKEKFETRMLTAFDKSFTSFEARLTKLEENMNSDRHLKVILDRLENFENDYKN---FRKDRIIFEKDLEKRMTDHSDRLYRQQIDDLSRFKREVRDSFAAVYETVNMMQSMFEKKQKLIEDNLRKEMGQLRKMVV 1220
              + S++  + E RL  QERT   L+++A +IK+++   L+ +QG   EE  AR+LL+ H++TIT++++++N+ I+ +E  I+ ++   +GT+  ++ +    I  + ++RGR+ RCDS   KL+ DI+ +    + +   + + ++      +N+++K   L  KIE   S+  +N+++   +   ++    F+ ++ +K I+++    +++ Q  +E +  K+    L+  ++     + +L K E  M  +  +  +  +LENF N  K      K + I E  + K+M+    R++     +L + + + +  F ++++++N +Q + + K  L +  ++K++ +L++ +V
Sbjct:   84 PAMPSNQTSQLEDRLSHQERTVAFLLEQAFRIKEDISACLHGSQGFRKEESLARKLLESHIQTITSIVKKLNQNIELLEDQIRIRDQVTTGTNFAVQDLNIKHIQGVGDLRGRVARCDSSIVKLSGDIQFIRHECRQMEKSVQELASALETISKNLDVKVMQLLGKIEASASEHTSNLKMVRGDYQHEMNLLEFKFNSLSKNIYEE----VETNQKWTENQFIKYGKDHLSHMNECLKVVQEKLEKSENKM--EEKMLQLSSKLENFMNSQKQEAEINKVKTI-ENKVSKKMSQLEKRIW----GELEKMQNDYQSGFKSIHDSLNSLQQIQKTKMDLEKHKVQKDLKKLQRKIV 427
[Close]
BLAST of Retinoid isomerohydrolase vs. UniProt/SwissProt
Match: sp|Q8TBF8|FA81A_HUMAN (Protein FAM81A OS=Homo sapiens OX=9606 GN=FAM81A PE=1 SV=3)

HSP 1 Score: 82.8037 bits (203), Expect = 5.595e-16
Identity = 92/354 (25.99%), Postives = 187/354 (52.82%), Query Frame = 3 
Query:  153 IIPYNRMNSGINSDKIGEFEFRLDVQERTTQQLIDKAVQIKQNLIENLNFTQGTWMEEKEARELLQEHVRTITAVIRQMNXXXXXXXXXXXXXXXXNSGTXXXXXXXXXXXXXXXXXXXXXXXXCDSVSAKLANDIRLLGESVKAIGMDLGQTSNKTNEKLQNIELKNQDLFNKIERLNSDSNTNIRISVDETNKQLFELDNRTKFIFDDLRHQIKSFQMQSEVEKEKFETRMLTAFDKSFTSFEARLTKLEENMNSD-RHLKVILDRLENFENDYKNFRKDRIIFEKDLEKRMTDHSDRLYRQQIDDLSRFKREVRDSFAAVYETVNMMQSMFEKKQKLIEDNLRKEMGQLRK 1211
            + PY+ ++       + + E R+   E+TT  L++ A +IK +++ +L   Q     ++ AR  L+EH+R ITA+++Q+N++I+ ++  I+ ++  + GT++ ++ +E  Q+S + ++RGR+ RCD+  A+L+ + +   E ++ +  +          K+++ E +   L N+++   S+ +T +++S  ++N QL  LD + K   ++L +QI S +   + E+E+ E  +L   D+     +      E +M      +   LD++E  E   K F   R   E   E++M     +L  Q   ++   K EV   F AVYE++  ++ + E K KL  D L+K++  ++K
Sbjct:   21 MAPYSSVSL------VEQLEDRILCHEKTTAALVEHAFRIKDDIVNSLQKMQNKGGGDRLARLFLEEHIRNITAIVKQLNRDIEVLQEQIRARDNISYGTNSALKTLEMRQLSGLGDLRGRVARCDASIARLSAEHKTTYEGLQHLNKEQQAAKLILETKIKDAEGQISQLLNRVDLSISEQSTKLKMSHRDSNHQLQLLDTKFKGTVEELSNQILSARSWLQQEQERIEKELLQKIDQLSLIVKENSGASERDMEKKLSQMSARLDKIE--EGQKKTFDGQRTRQE---EEKMHGRITKLELQMNQNIKEMKAEVNAGFTAVYESIGSLRQVLEAKMKLDRDQLQKQIQLMQK 363
[Close]
BLAST of Retinoid isomerohydrolase vs. UniProt/SwissProt
Match: sp|Q3UXZ6|FA81A_MOUSE (Protein FAM81A OS=Mus musculus OX=10090 GN=Fam81a PE=1 SV=2)

HSP 1 Score: 78.1814 bits (191), Expect = 2.015e-14
Identity = 86/343 (25.07%), Postives = 181/343 (52.77%), Query Frame = 3 
Query:  153 IIPYNRMNSGINSDKIGEFEFRLDVQERTTQQLIDKAVQIKQNLIENLNFTQGTWMEEKEARELLQEHVRTITAVIRQMNXXXXXXXXXXXXXXXXNSGTXXXXXXXXXXXXXXXXXXXXXXXXCDSVSAKLANDIRLLGESVKAIGMDLGQTSNKTNEKLQNIELKNQDLFNKIERLNSDSNTNIRISVDETNKQLFELDNRTKFIFDDLRHQIKSFQMQSEVEKEKFETRMLTAFDKSFTSFEARLTKLEENMNSDRHLKVILDRLENFENDYK-NFRKDRIIFEKDLEKRMTDHSDRLYRQQIDDLSRFKREVRDSFAAVYETVNMMQSMFEKKQKLIED 1178
            + PY+ ++       + + E R+   E+TT  L++ A +IK +++ +L   Q     ++ AR  L+EH+R ITA+++Q+N++I+ ++  I+ ++  + GT++ ++ +E  Q+S + ++RGR+ RCD+  A+L+ + +   E ++ +  +          K+++ E +   L ++++   S+ +T +++S  ++N QL  LD + K   ++L +QI S +   + E+E+ E  +L   D    S   +        + ++ L  +  RL+  E   K N    R   E+ +  R++    +L  Q  +D+   K EV   F+A+YE++  ++ + E K KL  D
Sbjct:   18 MAPYSSVSL------VEQLEDRILCHEKTTAALVEHAFRIKDDIVSSLQKMQNKGGGDRLARLFLEEHIRNITAIVKQLNRDIEVLQEQIRARDNISYGTNSALKTLEMRQLSGLGDLRGRVARCDASIARLSAEHKSTYEGLQHLNKEQQAAKLILETKIKDAEGQISQLLSRVDLSISEQSTKLKMSHRDSNHQLQLLDTKFKGTVEELSNQILSARSWLQQEQERIEKELLQKID--HLSLIVKENSGANERDVEKKLSQMSARLDKIEESQKRNAEGQRKPDEEKVHGRIS----KLELQMTEDMKEMKAEVNAGFSAIYESIGSLRQVLEAKMKLDRD 348
[Close]
BLAST of Retinoid isomerohydrolase vs. UniProt/SwissProt
Match: sp|Q0II90|FA81B_BOVIN (Protein FAM81B OS=Bos taurus OX=9913 GN=FAM81B PE=2 SV=1)

HSP 1 Score: 72.4034 bits (176), Expect = 1.979e-12
Identity = 89/373 (23.86%), Postives = 197/373 (52.82%), Query Frame = 3 
Query:  132 ARKNSGQIIPY----NRMNSGINSDKIGEFEFRLDVQERTTQQLIDKAVQIKQNLIENLNFTQGTWMEEKEARELLQEHVRTITAVIRQMNXXXXXXXXXXXXXXXXNSGTXXXXXXXXXXXXXXXXXXXXXXXXCDSVSAKLANDIRLLGESVKAIGMDLGQTSNKTNEKLQNIELKNQDLFNKIERLNSDSNTNIRISVDETNKQLFELDNRTKFIFDDLRHQIKSFQMQSEVEKEKFETRMLTAFDKSFTSFEARLTKLEENMNSDRHLKVILDRLENFENDYKNFRKDRIIFEKDL------EKRMTDHSDRLYRQQIDDLSRFKREVRDSFAAVYETVNMMQSMFEKKQKLIEDNLRKEMGQLRKMVV 1220
            + KNS  ++ Y    +     I + +  + E RL+ Q+RT   L+++A +IK+++   L  T G   EE  AR+LL+ H++TIT++++++++ I+ IE  IK ++   +GT+  ++ + N  +  + ++RGR+ RCDS   KL+ DI  +    + +   + +  +      +N++ K   L  KIE  +S+  +N+++   +   ++  L+ +   +  +L  ++++ Q ++E +  K+E   L+  ++     + +L   E+NM  +  L  +  +LENF N  K        +E DL      E +++    +L +Q  D+L + + E +  F ++++++N +Q + + K  L    ++K++ +L++ + 
Sbjct:   47 STKNSTDLVEYVDKGHSFLPAIPNTQRSQLEDRLNNQDRTIAFLLEQAFRIKEDISACLQGTHGFRKEESLARKLLENHIQTITSIVKKLSQNIEMIEEQIKARDLVATGTNFAVQDLSNKHLQGVGDLRGRVARCDSSIMKLSGDIHFIRNEHQQLEKTIQEMISSLQTVSKNLDTKVMQLLEKIEASSSEQISNLKMVQGDYRHEMNLLEFKFNSLSLNLYEEMENHQKRTENQLIKYEQEQLSRANQCLALLQEKLDMSEKNM--EEKLLKLSSKLENFINTEK--------YEADLNKIKHTENKLSKKMSQLEKQIWDELEKMQDEYQSGFKSIHDSLNSLQRIQKTKMDLENYKVQKDLKKLQRKIA 409
[Close]
BLAST of Retinoid isomerohydrolase vs. UniProt/SwissProt
Match: sp|Q96LP2|FA81B_HUMAN (Protein FAM81B OS=Homo sapiens OX=9606 GN=FAM81B PE=1 SV=4)

HSP 1 Score: 71.633 bits (174), Expect = 4.135e-12
Identity = 78/340 (22.94%), Postives = 185/340 (54.41%), Query Frame = 3 
Query:  201 GEFEFRLDVQERTTQQLIDKAVQIKQNLIENLNFTQGTWMEEKEARELLQEHVRTITAVIRQMNXXXXXXXXXXXXXXXXNSGTXXXXXXXXXXXXXXXXXXXXXXXXCDSVSAKLANDIRLLGESVKAIGMDLGQTSNKTNEKLQNIELKNQDLFNKIERLNSDSNTNIRISVDETNKQLFELDNRTKFIFDDLRHQIKSFQMQSEVEKEKFETRMLTAFDKSFTSFEARLTKLEENMNSDRHLKVILDRLENFENDYKNFRKDRIIFEKDLEKRMTDHSDRLYRQQIDDLSRFKREVRDSFAAVYETVNMMQSMFEKKQKLIEDNLRKEMGQLRKMVV 1220
            G+ E RL+ Q RT   L+++A +IK+++   L  T G   EE  AR+LL+ H++TIT++++++++ I+ +E  I+ ++   +GT+  + +I    +  + ++RGR+ RCDS   KL+ DI L  +  + I   + +         +N+++K   L  KIE  +S+  +N+++   +   ++  L+ +   +  +L  ++++ +  +E +  K+    L   ++     + +L K E  M  +  L  +  ++ENF N  K  ++ ++   K +E +++   +++ +Q   +L   + E +  F +++++++ +Q + + K  L +  ++K++ +L++ +V
Sbjct:  112 GQLEDRLNNQARTIAFLLEQAFRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSIVKKLSQNIEILEDQIRARDQAATGTNFAVHEINIKHLQGVGDLRGRVARCDSSIVKLSGDIHLFRQEHRQIEKAIQEFVPALETLSKNLDMKVMQLLGKIETASSEQTSNLKMVQGDYRHEMNLLEFKFHSLSSNLYEEVENNKKWTENQFLKYRKDHLGHINECLKVLQEKLEKSENKM--EEKLLQLSSKVENFINTQK--QETQLSKVKHMENKLSKKMEQMEKQIWGELETMQNEYQSGFKSIHDSLSSLQQIQKTKMDLEKYKVQKDLKKLQRKIV 447
[Close]
BLAST of Retinoid isomerohydrolase vs. TrEMBL
Match: A0A1S3JNF2 (protein FAM81A OS=Lingula unguis OX=7574 GN=LOC106174461 PE=4 SV=1)

HSP 1 Score: 205.297 bits (521), Expect = 6.015e-58
Identity = 127/347 (36.60%), Postives = 234/347 (67.44%), Query Frame = 3 
Query:  186 NSDKIGEFEFRLDVQERTTQQLIDKAVQIKQNLIENLNFTQGTWMEEKEARELLQEHVRTITAVIRQMNXXXXXXXXXXXXXXXXNSGTXXXXXXXXXXXXXXXXXXXXXXXXCDSVSAKLANDIRLLGESVKAIGMDLGQTSNKTNEKLQNIELKNQDLFNKIERLNSDSNTNIRISVDETNKQLFELDNRTKFIFDDLRHQIKSFQMQSEVEKEKFETRMLTAFDKSFTSFEARLTKLEENMNSDRHLKVILDRLENFENDYKNFRKDRIIFEKDLEKRMTDHSDRLYRQQIDDLSRFKREVRDSFAAVYETVNMMQSMFEKKQKLIEDNLRKEMGQLRKMVVLI 1226
            ++ ++   E RL  QERTTQ L++KAV+IK+++++N ++T GTW  EK ARELLQ+H+RTIT V+++++ +IK +E  ++ K+++ S  S  ++ +E + ++ ++++RGR+ RCD+  AKLA+D +   ES+K++  +    + K  EKLQ+IE K  ++ N+++++N +    I+    ++++QL  LD +T+ +F++LRH + + +   E E+EK E+R+ T  D+S TS + RL K+E+ +  D    V+  +L+  E++    R+  I  E+  E R + H D   R+Q +++S+ K+E R++FA ++E++  M+S+ + K+KL+E+ +RKE+GQ+RKMVVL+
Sbjct:   49 SASRVEHLEERLAHQERTTQALLEKAVRIKEDILDNTSYTHGTWQNEKRARELLQDHIRTITDVVKKLDWDIKIVEDQLRMKDSSTSQASAAVKNLEVHHVAGLTDLRGRVARCDASIAKLASDSKACFESIKSLNTEHQNLNTKLMEKLQDIENKMAEINNRLDKVNIEHTLKIKHMEGDSSQQLSHLDTKTRALFEELRHTLTASKAVEEAEREKMESRLFTHLDRSSTSRDGRLDKMEKKV--DEWFHVVEKKLQKMEDEMIRDRERTIKTEQAFESRFSQHVDVSIRKQNEEISKVKKECREAFATLHESIVSMKSVQDGKRKLLEEQIRKEIGQIRKMVVLL 393
[Close]
BLAST of Retinoid isomerohydrolase vs. TrEMBL
Match: A0A267GVP9 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig013284g1 PE=4 SV=1)

HSP 1 Score: 199.134 bits (505), Expect = 1.130e-55
Identity = 130/390 (33.33%), Postives = 234/390 (60.00%), Query Frame = 3 
Query:   66 RSPNRNDYLPPIKSMYDDSYGSARKNSGQIIPYNRMNSGINSDKIGEFEFRLDVQERTTQQLIDKAVQIKQNLIENLNFTQGTWMEEKEARELLQEHVRTITAVIRQMNXXXXXXXXXXXXXXXXNSGTXXXXXXXXXXXXXXXXXXXXXXXXCDSVSAKLANDIRLLGESVKAIGMDLGQTSNKTNEKLQNIELKNQDLFNKIERLNSDSNTNIRISVDETNKQLFELDNRTKFIFDDLRHQIKSFQMQSEVEKEKFETRMLTAFDKSFTSFEARLTKLEENMNSDRHL---KVILDRLENFENDYKNFRKDRIIFEKDLEKRMTDHSDRLYRQQIDDLSRFKREVRDSFAAVYETVNMMQSMFEKKQKLIEDNLRKEMGQLRKMVVLI 1226
            RS +R   LP +++ YDDSY          + Y     G   +++ + E RL   E + + L++K+V++K  ++EN+ +T G+W EEK+ARELLQ+H++T+TAV++QM K+IK +E  IK+++   +G S  ++ +E + ++ I+++RGR+ RCD+   KLA D++  GE+V+ +     +   +  ++L  +E    +L + +ER+  ++   ++ S + ++K + +LD +T+ +  +L HQ+++       E EK ETR+    DK   + +AR+ K+E +     HL   K +  RL   E D++  +       ++LE ++    D  YR Q  +L + KRE+R+ F+ V+ETV+ M+S+ E K KL+E++LRK++ Q+RKMVVLI
Sbjct:    5 RSQSRGGILPHLRTTYDDSYQPT-------VRYAGGGGGGGGNRLEDLEARLVQAESSLRSLLEKSVKMKSEIMENMTYTHGSWQEEKDARELLQDHIKTVTAVVKQMGKDIKHLEDEIKQRDQGITGQSTALKTLETHHVAGITDLRGRVARCDASIGKLAADLKQNGETVRMLSQSENEEHQRLKDRLAQMERSMAELHSFMERVGMENTMQVKASEETSSKNISQLDVKTRQVIAELTHQLENLSKHVNAEVEKLETRVYAYLDKHIAARDARMDKIEAD-----HLDFEKSMFARLAALEEDHQKHKSTTARAHQELESKVQQFYDSFYRAQNSELVKLKRELREGFSTVHETVSSMRSVTEGKIKLLEESLRKDIAQIRKMVVLI 382
[Close]
BLAST of Retinoid isomerohydrolase vs. TrEMBL
Match: A0A267G9B3 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig013284g3 PE=4 SV=1)

HSP 1 Score: 197.978 bits (502), Expect = 2.760e-55
Identity = 133/391 (34.02%), Postives = 234/391 (59.85%), Query Frame = 3 
Query:   66 RSPNRNDYLPPIKSMYDDSY-GSARKNSGQIIPYNRMNSGINSDKIGEFEFRLDVQERTTQQLIDKAVQIKQNLIENLNFTQGTWMEEKEARELLQEHVRTITAVIRQMNXXXXXXXXXXXXXXXXNSGTXXXXXXXXXXXXXXXXXXXXXXXXCDSVSAKLANDIRLLGESVKAIGMDLGQTSNKTNEKLQNIELKNQDLFNKIERLNSDSNTNIRISVDETNKQLFELDNRTKFIFDDLRHQIKSFQMQSEVEKEKFETRMLTAFDKSFTSFEARLTKLEENMNSDRHL---KVILDRLENFENDYKNFRKDRIIFEKDLEKRMTDHSDRLYRQQIDDLSRFKREVRDSFAAVYETVNMMQSMFEKKQKLIEDNLRKEMGQLRKMVVLI 1226
            RS +R   LP +++ YDDSY  + R   G     NR+          + E RL   E + + L++K+V++K  ++EN+ +T GTW EEK+ARELLQ+H++T+TAV++QM K+IK +E  IK+++   +G S  ++ +E + ++ I+++RGR+ RCD+   KLA D++  GE+V+ +     +   +  ++L  +E    +L + +ER+  ++   ++ S + ++K + +LD +T+ +  +L HQ+++       E EK ETR+    DK   + +AR+ K+E +     HL   K +  RL   E D++  +       ++LE ++    D  YR Q  +L + KRE+R+ F+ V+ETV+ M+S+ E K KL+E++LRK++ Q+RKMVVLI
Sbjct:    5 RSQSRGGILPHLRTTYDDSYQPTVRYAGGGGGGGNRLE---------DLEARLVQAESSLRSLLEKSVKMKSEIMENMTYTHGTWQEEKDARELLQDHIKTVTAVVKQMGKDIKHLEDEIKQRDQGITGQSTALKTLETHHVAGITDLRGRVARCDASIGKLAADLKQNGETVRMLSQSENEEHQRLKDRLAQMERSMAELHSFMERVGMENTMQVKASEETSSKNISQLDVKTRQVIAELTHQLENLSKHVNAEVEKLETRVYAYLDKHIAARDARMDKIEAD-----HLDFEKSMFARLAALEEDHQKHKSTTARAHQELESKVQQFYDSFYRAQNSELVKLKRELREGFSTVHETVSSMRSVTEGKIKLLEESLRKDIAQIRKMVVLI 381
[Close]
BLAST of Retinoid isomerohydrolase vs. TrEMBL
Match: A0A267GXK0 (Uncharacterized protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig013284g2 PE=4 SV=1)

HSP 1 Score: 198.364 bits (503), Expect = 3.579e-55
Identity = 133/396 (33.59%), Postives = 236/396 (59.60%), Query Frame = 3 
Query:   51 ILEMSRSPNRNDYLPPIKSMYDDSY-GSARKNSGQIIPYNRMNSGINSDKIGEFEFRLDVQERTTQQLIDKAVQIKQNLIENLNFTQGTWMEEKEARELLQEHVRTITAVIRQMNXXXXXXXXXXXXXXXXNSGTXXXXXXXXXXXXXXXXXXXXXXXXCDSVSAKLANDIRLLGESVKAIGMDLGQTSNKTNEKLQNIELKNQDLFNKIERLNSDSNTNIRISVDETNKQLFELDNRTKFIFDDLRHQIKSFQMQSEVEKEKFETRMLTAFDKSFTSFEARLTKLEENMNSDRHL---KVILDRLENFENDYKNFRKDRIIFEKDLEKRMTDHSDRLYRQQIDDLSRFKREVRDSFAAVYETVNMMQSMFEKKQKLIEDNLRKEMGQLRKMVVLI 1226
            ++   RS +R   LP +++ YDDSY  + R   G     NR+          + E RL   E + + L++K+V++K  ++EN+ +T GTW EEK+ARELLQ+H++T+TAV++QM K+IK +E  IK+++   +G S  ++ +E + ++ I+++RGR+ RCD+   KLA D++  GE+V+ +     +   +  ++L  +E    +L + +ER+  ++   ++ S + ++K + +LD +T+ +  +L HQ+++       E EK ETR+    DK   + +AR+ K+E +     HL   K +  RL   E D++  +       ++LE ++    D  YR Q  +L + KRE+R+ F+ V+ETV+ M+S+ E K KL+E++LRK++ Q+RKMVVLI
Sbjct:   16 VMTSPRSQSRGGILPHLRTTYDDSYQPTVRYAGGGGGGGNRLE---------DLEARLVQAESSLRSLLEKSVKMKSEIMENMTYTHGTWQEEKDARELLQDHIKTVTAVVKQMGKDIKHLEDEIKQRDQGITGQSTALKTLETHHVAGITDLRGRVARCDASIGKLAADLKQNGETVRMLSQSENEEHQRLKDRLAQMERSMAELHSFMERVGMENTMQVKASEETSSKNISQLDVKTRQVIAELTHQLENLSKHVNAEVEKLETRVYAYLDKHIAARDARMDKIEAD-----HLDFEKSMFARLAALEEDHQKHKSTTARAHQELESKVQQFYDSFYRAQNSELVKLKRELREGFSTVHETVSSMRSVTEGKIKLLEESLRKDIAQIRKMVVLI 397
[Close]
BLAST of Retinoid isomerohydrolase vs. TrEMBL
Match: R7UIM2 (Uncharacterized protein OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_149793 PE=4 SV=1)

HSP 1 Score: 192.2 bits (487), Expect = 3.734e-53
Identity = 131/382 (34.29%), Postives = 227/382 (59.42%), Query Frame = 3 
Query:  129 SARKNSGQIIPY-------NRMNSGINSDKIGEFEFRLDVQERTTQQLIDKAVQIKQNLIENLNFTQGTWMEEKEARELLQEHVRTITAVIRQMNXXXXXXXXXXXXXXXXNSGTXXXXXXXXXXXXXXXXXXXXXXXXCDSVSAKLANDIRLLGESVKAIGMDLGQTSNKTNEKLQNIELKNQDLFNKIERLNSDSNTNIRISVDETNKQLFELDNRTKFIFDDLRHQIKSFQMQSEVEKEKFETRMLTAFDKSFTSFEARLTK----LEENMNSDRHLKVILDRLENFENDYKNFRKDRII-----FEKDLEKRMTDHSDRLYRQQIDDLSRFKREVRDSFAAVYETVNMMQSMFEKKQKLIEDNLRKEMGQLRKMVVLI 1226
            S R  +G ++P            S     ++   E RL  QERTT  L+D+A +IK+++I+NLN T GTW EEK +R+LLQEH+RTIT V+R+++++I  +E  IK +E  + GT + ++ +E + ++ ++++RGR+ RCD+  A+L+ D++   ++ KA+     +   +  EKLQ++E++  D+  ++++ +S     IR   +E+ + +  LD+RT+   ++ + +I   +     E+EK E R+ T  DK     + +  K    LE+ +N    L V L R E    D     +DRI+     +E  +   + DHS    R+Q +DL++ KRE+R+ FAAV+E+++ M+ + + K+KL+E+ LRKE+GQ+RKMVVLI
Sbjct:    4 SGRGQNGALLPLRAGGGEEQAWQSPRAPSRLDHLEERLVSQERTTHGLVDRAYKIKEDIIDNLNITHGTWQEEKRSRQLLQEHIRTITDVVRKLSRDIMFLEEQIKSREGYSEGTQSAVKNLEMHHVAGVTDLRGRVARCDAAIARLSGDLKACHDATKALSQQQLENQQRVTEKLQSLEVRTGDILGRLDKWSSQCEIQIRHVENESGQNINALDSRTRLQLEEAQREIGQLKSSEVNEREKLEMRISTTLDKLMQQRDIKTDKTTKSLEDAVN---FLSVRLQRHE----DESALERDRIMAGRQAYESKVTAMLQDHS----RRQAEDLAKLKREMREGFAAVHESISNMKQILDGKRKLLEEQLRKEIGQIRKMVVLI 374
[Close]
BLAST of Retinoid isomerohydrolase vs. Ensembl Cavefish
Match: fam81b (family with sequence similarity 81 member B [Source:ZFIN;Acc:ZDB-GENE-130530-586])

HSP 1 Score: 47.3654 bits (111), Expect = 2.634e-6
Identity = 36/133 (27.07%), Postives = 81/133 (60.90%), Query Frame = 3 
Query:  252 IDKAVQIKQNLIENLNFTQGTWMEEKEARELLQEHVRTITAVIRQMNXXXXXXXXXXXXXXXXNSGTXXXXXXXXXXXXXXXXXXXXXXXXCDSVSAKLANDIRLLGESVKAIGMDLGQTSNKTNEKLQNIEL 650
            + +A QIK+ ++ +L+ TQG+ + E  AR+LL+ H++TIT +++Q++K+I+ +E+ I ++++  SGT     Q  +++  +          CD+  AKL+ D++   + +  +  ++G+  +    +L+++EL
Sbjct:    1 MQQAFQIKEEMVSSLHATQGSVLMEASARKLLENHIQTITHIVKQLSKDIQVLEAQIVQRDSVASGT-TFAVQKLDHKNLTGIGDLRGRVACDASIAKLSGDVKAGEQEISQLLKEMGEMRSGIELRLKDLEL 132
[Close]
BLAST of Retinoid isomerohydrolase vs. Ensembl Nematostella
Match: EDO31612 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SXE7])

HSP 1 Score: 122.479 bits (306), Expect = 4.024e-31
Identity = 107/376 (28.46%), Postives = 205/376 (54.52%), Query Frame = 3 
Query:  129 SARKNSGQIIPYNRMNSGINSDKI-GEFEFRLDV-------QERTTQQLIDKAVQIKQNLIENLNFTQGTWMEEKEARELLQEHVRTITAVIRQMNXXXXXXXXXXXXXXXXNSGTXXXXXXXXXXXXXXXXXXXXXXXXCDSVSAKLANDIRLLGESVKAIGMDLGQTSNKTNEKLQNIELKNQDLFNKIERLNSDSNTNIRISVDETNKQLFELDNRTKFIFDDLRHQIKSFQMQSEVEKEKFETRMLTAFDKSFTSFEARLTKLEENM--NSDRHLKVILDRLENFENDYKNFRKDRIIFEKDLEKRMTDHSDRLYRQQIDDLSRFKREVRDSFAAVYETVNMMQSMFEKKQKLIEDNLRKEMGQLRKMVVLI 1226
            S+R  S +      + +G N+  + GE   R+DV       QE+TT+ LID+A+++K++++E+L+  Q  W  EK AR LLQEH+RTIT+V++++++EI+ +E  ++ KE+  +G +   + +E + ++ ++++RGR+ RCD    ++ +D+R + E++  +      ++ + NE+ Q ++    DL  K E+ N++ +T+I     + + Q+  LD++TK   +D+R  I S +  +E E  K    +   F      FE  +   +E +    D +L  I   +   ++ Y N  + R+       K      D + R   D  +  ++E R  F  V+E++  +Q + E K KL+ED+L+K +  + +MVVL+
Sbjct:    5 SSRTRSPKRTSLPAITNGDNTLALRGETLSRMDVLEDRIYNQEKTTRSLIDRALRVKEDIVESLSIAQVNWQGEKRARALLQEHIRTITSVVKRLSREIEVLEDELRSKESKVAGNATAFKNLELHHVAGVTDLRGRVARCDHAIERMVSDLRAIAEALNELRQRQENSTKENNERFQGLQSSINDLVMKFEKYNTEQHTSIEKLKGQADDQVTRLDSKTKSAVEDVRANITSTRQWTESEYFK----LTKEFQGRLERFEGVIINRQEKLEFKVDSYLSKIEKMISEEKDKYFNLWEVRL-------KETKSEQDHVLR---DTCAGLRQEYRLGFNTVHESMTTLQKVLEAKLKLVEDDLKKSINNILRMVVLV 366
[Close]
BLAST of Retinoid isomerohydrolase vs. Planmine SMEST
Match: SMESG000054001.1 (SMESG000054001.1)

HSP 1 Score: 692.575 bits (1786), Expect = 0.000e+0
Identity = 388/389 (99.74%), Postives = 388/389 (99.74%), Query Frame = 3 
Query:   60 MSRSPNRNDYLPPIKSMYDDSYGSARKNSGQIIPYNRMNSGINSDKIGEFEFRLDVQERTTQQLIDKAVQIKQNLIENLNFTQGTWMEEKEARELLQEHVRTITAVIRQMNXXXXXXXXXXXXXXXXNSGTXXXXXXXXXXXXXXXXXXXXXXXXCDSVSAKLANDIRLLGESVKAIGMDLGQTSNKTNEKLQNIELKNQDLFNKIERLNSDSNTNIRISVDETNKQLFELDNRTKFIFDDLRHQIKSFQMQSEVEKEKFETRMLTAFDKSFTSFEARLTKLEENMNSDRHLKVILDRLENFENDYKNFRKDRIIFEKDLEKRMTDHSDRLYRQQIDDLSRFKREVRDSFAAVYETVNMMQSMFEKKQKLIEDNLRKEMGQLRKMVVLI 1226
            MSRSPNRNDYLPPIKSMYDDSYGSARKNSGQIIPYNRMNSGINSDKIGEFEFRLDVQERTTQQLIDKAVQIKQNLIENLNFTQGTWMEEKEARELLQEHVRTITAVIRQMNKEIKTIESTIKEKETTNSGTSNIIRQIENNQISSISEIRGRIGRCDSVSAKLANDIRLLGESVKAIGMDLGQTSNKTNEKLQNIELKNQDLFNKIERLNSDSNTNIRISVDETNKQLFELDNRTKFIFDDLRHQIKSFQMQSEVEKEKFETRMLTAFDKSFTSFEARLTKLEENMNSDRHLKVILDRLENFENDYKNFRKDRI FEKDLEKRMTDHSDRLYRQQIDDLSRFKREVRDSFAAVYETVNMMQSMFEKKQKLIEDNLRKEMGQLRKMVVLI
Sbjct:    1 MSRSPNRNDYLPPIKSMYDDSYGSARKNSGQIIPYNRMNSGINSDKIGEFEFRLDVQERTTQQLIDKAVQIKQNLIENLNFTQGTWMEEKEARELLQEHVRTITAVIRQMNKEIKTIESTIKEKETTNSGTSNIIRQIENNQISSISEIRGRIGRCDSVSAKLANDIRLLGESVKAIGMDLGQTSNKTNEKLQNIELKNQDLFNKIERLNSDSNTNIRISVDETNKQLFELDNRTKFIFDDLRHQIKSFQMQSEVEKEKFETRMLTAFDKSFTSFEARLTKLEENMNSDRHLKVILDRLENFENDYKNFRKDRIGFEKDLEKRMTDHSDRLYRQQIDDLSRFKREVRDSFAAVYETVNMMQSMFEKKQKLIEDNLRKEMGQLRKMVVLI 389
The following BLAST results are available for this feature:
BLAST of Retinoid isomerohydrolase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
FAM81A1.165e-1625.99family with sequence similarity 81 member A [Sourc... [more]
FAM81B8.611e-1322.94family with sequence similarity 81 member B [Sourc... [more]
FAM81B9.149e-737.50family with sequence similarity 81 member B [Sourc... [more]
FAM81B3.004e-637.50family with sequence similarity 81 member B [Sourc... [more]
FAM81A6.159e-633.85family with sequence similarity 81 member A [Sourc... [more]
back to top
BLAST of Retinoid isomerohydrolase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
back to top
BLAST of Retinoid isomerohydrolase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
back to top
BLAST of Retinoid isomerohydrolase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
fam81b3.566e-930.26family with sequence similarity 81 member B [Sourc... [more]
back to top
BLAST of Retinoid isomerohydrolase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1
Match NameE-valueIdentityDescription
FAM81B7.291e-923.12family with sequence similarity 81 member B [Sourc... [more]
back to top
BLAST of Retinoid isomerohydrolase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Fam81a2.881e-1525.07family with sequence similarity 81, member A [Sour... [more]
Fam81b3.391e-1523.38family with sequence similarity 81, member B [Sour... [more]
back to top
BLAST of Retinoid isomerohydrolase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 4
Match NameE-valueIdentityDescription
sp|Q8TBF8|FA81A_HUMAN5.595e-1625.99Protein FAM81A OS=Homo sapiens OX=9606 GN=FAM81A P... [more]
sp|Q3UXZ6|FA81A_MOUSE2.015e-1425.07Protein FAM81A OS=Mus musculus OX=10090 GN=Fam81a ... [more]
sp|Q0II90|FA81B_BOVIN1.979e-1223.86Protein FAM81B OS=Bos taurus OX=9913 GN=FAM81B PE=... [more]
sp|Q96LP2|FA81B_HUMAN4.135e-1222.94Protein FAM81B OS=Homo sapiens OX=9606 GN=FAM81B P... [more]
back to top
BLAST of Retinoid isomerohydrolase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1S3JNF26.015e-5836.60protein FAM81A OS=Lingula unguis OX=7574 GN=LOC106... [more]
A0A267GVP91.130e-5533.33Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A267G9B32.760e-5534.02Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A267GXK03.579e-5533.59Uncharacterized protein (Fragment) OS=Macrostomum ... [more]
R7UIM23.734e-5334.29Uncharacterized protein OS=Capitella teleta OX=283... [more]
back to top
BLAST of Retinoid isomerohydrolase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
fam81b2.634e-627.07family with sequence similarity 81 member B [Sourc... [more]
back to top
BLAST of Retinoid isomerohydrolase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
back to top
BLAST of Retinoid isomerohydrolase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
back to top
BLAST of Retinoid isomerohydrolase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO316124.024e-3128.46Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
back to top
BLAST of Retinoid isomerohydrolase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 0
Match NameE-valueIdentityDescription
back to top
BLAST of Retinoid isomerohydrolase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000054001.10.000e+099.74SMESG000054001.1[more]
back to top
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30033232 ID=SMED30033232|Name=Retinoid isomerohydrolase|organism=Schmidtea mediterranea sexual|type=transcript|length=1362bp
GTTTAATCTATTAAACCTTGACAACTGTTAATCGCTGGTATTTTAAATAA
ATACTTGAAATGTCAAGAAGTCCAAATCGAAATGATTATTTACCACCGAT
CAAATCAATGTATGACGATAGTTATGGATCAGCAAGAAAGAATTCTGGAC
AAATTATTCCTTATAATCGAATGAATAGTGGGATAAATAGTGACAAAATC
GGTGAATTCGAATTTAGACTAGACGTACAAGAACGAACTACCCAACAATT
AATTGACAAAGCTGTTCAAATAAAACAAAACTTAATTGAAAATTTAAATT
TCACCCAAGGAACCTGGATGGAAGAAAAAGAAGCCCGCGAATTGCTACAG
GAGCATGTCAGAACAATCACGGCTGTAATTAGGCAAATGAATAAAGAAAT
AAAGACAATCGAGTCGACTATCAAAGAAAAAGAAACTACAAATTCCGGAA
CAAGCAATATAATTCGACAAATTGAAAACAATCAGATATCGTCAATTAGT
GAAATAAGGGGCCGGATAGGTCGATGCGACTCGGTGTCGGCAAAATTGGC
AAATGACATTAGACTGCTTGGAGAATCTGTAAAGGCAATTGGAATGGATC
TAGGTCAAACATCAAATAAAACTAATGAAAAGCTGCAGAACATTGAATTA
AAGAATCAAGACTTGTTCAACAAAATCGAGCGCTTGAACTCCGACAGCAA
TACAAACATCCGGATTTCTGTTGATGAAACAAATAAGCAGTTATTTGAGC
TCGACAATCGCACAAAATTTATCTTTGATGATCTTCGGCACCAAATCAAA
AGTTTCCAGATGCAATCAGAAGTTGAAAAAGAAAAATTTGAAACGAGAAT
GTTAACGGCATTTGATAAATCATTCACATCCTTTGAAGCGAGATTGACAA
AGTTGGAAGAAAATATGAATTCAGATCGCCATTTAAAAGTTATATTGGAC
AGACTGGAAAATTTTGAGAATGACTACAAAAATTTCCGAAAGGATCGAAT
CATATTCGAGAAAGATCTCGAAAAGCGAATGACAGATCATTCCGATAGAC
TTTATCGACAACAAATTGATGATCTGTCGAGATTCAAACGGGAAGTTCGG
GACAGTTTTGCTGCAGTTTATGAGACAGTGAACATGATGCAATCAATGTT
TGAAAAGAAACAAAAATTAATTGAAGATAACCTAAGGAAAGAAATGGGAC
AATTGAGGAAAATGGTCGTCCTTATTTGATTGGATACTGCCTCGGTGTTG
TAGATGCCCACTGCCTACGTTGGAAATGGCAGAATTTATCATATAATTCC
ATCGGAATCTGACTAGTAAACATCTTTCCTCAATCGATTTCATATAGATG
CTTATTTTTATA
back to top

protein sequence of SMED30033232-orf-1

>SMED30033232-orf-1 ID=SMED30033232-orf-1|Name=SMED30033232-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=390bp
MSRSPNRNDYLPPIKSMYDDSYGSARKNSGQIIPYNRMNSGINSDKIGEF
EFRLDVQERTTQQLIDKAVQIKQNLIENLNFTQGTWMEEKEARELLQEHV
RTITAVIRQMNKEIKTIESTIKEKETTNSGTSNIIRQIENNQISSISEIR
GRIGRCDSVSAKLANDIRLLGESVKAIGMDLGQTSNKTNEKLQNIELKNQ
DLFNKIERLNSDSNTNIRISVDETNKQLFELDNRTKFIFDDLRHQIKSFQ
MQSEVEKEKFETRMLTAFDKSFTSFEARLTKLEENMNSDRHLKVILDRLE
NFENDYKNFRKDRIIFEKDLEKRMTDHSDRLYRQQIDDLSRFKREVRDSF
AAVYETVNMMQSMFEKKQKLIEDNLRKEMGQLRKMVVLI*
back to top
Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0016787hydrolase activity
GO:0003674molecular_function
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000034epidermis
PLANA:0000099neuron
PLANA:0000418head
Vocabulary: INTERPRO
TermDefinition
IPR029619FAM81
IPR013083Znf_RING/FYVE/PHD
Vocabulary: cellular component
TermDefinition
GO:0005575cellular_component
Vocabulary: biological process
TermDefinition
GO:0008150biological_process
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 292..319
NoneNo IPR availableCOILSCoilCoilcoord: 107..127
NoneNo IPR availableCOILSCoilCoilcoord: 185..212
IPR029619Protein FAM81PANTHERPTHR22420UNCHARACTERIZEDcoord: 42..388