Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30033121 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 14
Homology
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Human
Match: TPTE2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 [Source:HGNC Symbol;Acc:HGNC:17299]) HSP 1 Score: 319.701 bits (818), Expect = 8.745e-102 Identity = 173/449 (38.53%), Postives = 261/449 (58.13%), Query Frame = 2
Query: 341 LAFGFSCIFLIEIILRLHGIGIKTYFCNWINLVDFLVVFVTSVISIV----DITLETSTXXXXXXXXXXXXXXXXXXXXXXNYKKFI-KSSRHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDYRSDVSLLQFAYQCPTIIINCHFLFRLSLSREQLDNPHKKTTWNIYNSEFKVDIFF 1672
++ FL++++LR+ G + YF + N++D ++ + ++ ++ DI L + + L + I L + K+ + K R + SENKRR+ G+DLDL YVT+R+IAMSFPSSG + YRN I +V +F + K+ +Y++YNLC ERAYD K F+++V R M+ DHNVP L E++ F K EW+ + +NI+A+HCKGGKGRTGTM+C LI S +F AE L YFG+RRT+ KFQGVETPSQNRYVGYF +K ++ +P ++L I++ I + C + ++ ++ ++ + +LG+ C + D E+ + + I + D P L+DDVK++FF+ N +P+ YD C FFFWF+T FI++ RL L R +LDNPHK+ W IY EF V+I F
Sbjct: 111 ISLAIGLFFLMDVLLRVFVEGRQQYFSDLFNILDTAIIVIPLLVDVIYIFFDIKLLRNIPRWTHLVRLLRLIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVME---------KKVVFSSTSLGN---CSILHDIETDK--ILINVYDGPPLYDDVKVQFFSSN--LPKYYDNCPFFFWFNTSFIQNN------------------------RLCLPRNELDNPHKQKAWKIYPPEFAVEILF 519
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Human
Match: TPTE2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 [Source:HGNC Symbol;Acc:HGNC:17299]) HSP 1 Score: 308.916 bits (790), Expect = 4.305e-99 Identity = 157/365 (43.01%), Postives = 223/365 (61.10%), Query Frame = 2
Query: 578 KKFIKSSRHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDYRSDVSLLQFAYQCPTIIINCHFLFRLSLSREQLDNPHKKTTWNIYNSEFKVDIFF 1672
++ K R + SENKRR+ G+DLDL YVT+R+IAMSFPSSG + YRN I +V +F + K+ +Y++YNLC ERAYD K F+++V R M+ DHNVP L E++ F K EW+ + +NI+A+HCKGGKGRTGTM+C LI S +F AE L YFG+RRT+ KFQGVETPSQNRYVGYF +K ++ +P ++L I++ I + C + ++ ++ ++ + +LG+ C + D E+ + + I + D P L+DDVK++FF+ N +P+ YD C FFFWF+T FI++ RL L R +LDNPHK+ W IY EF V+I F
Sbjct: 84 RQLEKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVME---------KKVVFSSTSLGN---CSILHDIETDK--ILINVYDGPPLYDDVKVQFFSSN--LPKYYDNCPFFFWFNTSFIQNN------------------------RLCLPRNELDNPHKQKAWKIYPPEFAVEILF 408
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Human
Match: TPTE2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 [Source:HGNC Symbol;Acc:HGNC:17299]) HSP 1 Score: 309.686 bits (792), Expect = 6.968e-99 Identity = 157/365 (43.01%), Postives = 223/365 (61.10%), Query Frame = 2
Query: 578 KKFIKSSRHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDYRSDVSLLQFAYQCPTIIINCHFLFRLSLSREQLDNPHKKTTWNIYNSEFKVDIFF 1672
++ K R + SENKRR+ G+DLDL YVT+R+IAMSFPSSG + YRN I +V +F + K+ +Y++YNLC ERAYD K F+++V R M+ DHNVP L E++ F K EW+ + +NI+A+HCKGGKGRTGTM+C LI S +F AE L YFG+RRT+ KFQGVETPSQNRYVGYF +K ++ +P ++L I++ I + C + ++ ++ ++ + +LG+ C + D E+ + + I + D P L+DDVK++FF+ N +P+ YD C FFFWF+T FI++ RL L R +LDNPHK+ W IY EF V+I F
Sbjct: 118 RQLEKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVME---------KKVVFSSTSLGN---CSILHDIETDK--ILINVYDGPPLYDDVKVQFFSSN--LPKYYDNCPFFFWFNTSFIQNN------------------------RLCLPRNELDNPHKQKAWKIYPPEFAVEILF 442
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Human
Match: TPTE2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 [Source:HGNC Symbol;Acc:HGNC:17299]) HSP 1 Score: 309.686 bits (792), Expect = 6.968e-99 Identity = 157/365 (43.01%), Postives = 223/365 (61.10%), Query Frame = 2
Query: 578 KKFIKSSRHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDYRSDVSLLQFAYQCPTIIINCHFLFRLSLSREQLDNPHKKTTWNIYNSEFKVDIFF 1672
++ K R + SENKRR+ G+DLDL YVT+R+IAMSFPSSG + YRN I +V +F + K+ +Y++YNLC ERAYD K F+++V R M+ DHNVP L E++ F K EW+ + +NI+A+HCKGGKGRTGTM+C LI S +F AE L YFG+RRT+ KFQGVETPSQNRYVGYF +K ++ +P ++L I++ I + C + ++ ++ ++ + +LG+ C + D E+ + + I + D P L+DDVK++FF+ N +P+ YD C FFFWF+T FI++ RL L R +LDNPHK+ W IY EF V+I F
Sbjct: 118 RQLEKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVME---------KKVVFSSTSLGN---CSILHDIETDK--ILINVYDGPPLYDDVKVQFFSSN--LPKYYDNCPFFFWFNTSFIQNN------------------------RLCLPRNELDNPHKQKAWKIYPPEFAVEILF 442
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Human
Match: TPTE2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 [Source:HGNC Symbol;Acc:HGNC:17299]) HSP 1 Score: 309.686 bits (792), Expect = 2.047e-98 Identity = 157/365 (43.01%), Postives = 223/365 (61.10%), Query Frame = 2
Query: 578 KKFIKSSRHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDYRSDVSLLQFAYQCPTIIINCHFLFRLSLSREQLDNPHKKTTWNIYNSEFKVDIFF 1672
++ K R + SENKRR+ G+DLDL YVT+R+IAMSFPSSG + YRN I +V +F + K+ +Y++YNLC ERAYD K F+++V R M+ DHNVP L E++ F K EW+ + +NI+A+HCKGGKGRTGTM+C LI S +F AE L YFG+RRT+ KFQGVETPSQNRYVGYF +K ++ +P ++L I++ I + C + ++ ++ ++ + +LG+ C + D E+ + + I + D P L+DDVK++FF+ N +P+ YD C FFFWF+T FI++ RL L R +LDNPHK+ W IY EF V+I F
Sbjct: 155 RQLEKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVME---------KKVVFSSTSLGN---CSILHDIETDK--ILINVYDGPPLYDDVKVQFFSSN--LPKYYDNCPFFFWFNTSFIQNN------------------------RLCLPRNELDNPHKQKAWKIYPPEFAVEILF 479
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Celegans
Match: daf-18 (Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18 [Source:UniProtKB/Swiss-Prot;Acc:G5EE01]) HSP 1 Score: 129.798 bits (325), Expect = 3.653e-31 Identity = 67/184 (36.41%), Postives = 104/184 (56.52%), Query Frame = 2
Query: 599 RHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGP-NYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKK 1147
R S N+ R + DLD Y+TDR+IA+ +P++G A +RNS +F ++G N K++NL YD F+ V + + DH+ P LE + F + ++EWL D+++IAVHCK GKGRTG MIC LI + + L Y+ +++ K +GV PSQ RY+ Y+ +++
Sbjct: 50 RTAVSSNRCRTEYQNIDLDCAYITDRIIAIGYPATGIEANFRNSKVQTQQFLTRRHGKGNVKVFNLRGGYYYDADNFDGNVICFDMTDHHPPSLELMAPFCREAKEWLEADDKHVIAVHCKAGKGRTGVMICALLIYINFYPSPRQILDYYS-----IIRTKNNKGVTIPSQRRYIYYYHKLRE 228
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Fly
Match: Pten (gene:FBgn0026379 transcript:FBtr0089902) HSP 1 Score: 175.252 bits (443), Expect = 1.440e-48 Identity = 116/363 (31.96%), Postives = 179/363 (49.31%), Query Frame = 2
Query: 599 RHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSG-FTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKL-LKIEKIEITGAQKFYCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDY---RSDVSLLQFAYQCPTIIINCHFLFRLSLSREQLDNPHKKTTWNIYNSEFKVDIFF 1672
R+V S+ + R++ GYDLDL Y+ D +IAM +P+ L+RN + DV K + +YKIYNLC ER+YD F +V Y DHN P +E I F WL + N++AVHCK GKGRTGTMIC +L+ SG+ +A+ L ++ ++RT K +GV PSQ RYV YF + S +P K+ L + +I + + E S+ + + + P + + K +LTI P++ +K F KK P DK FW +T F+ +Y SD ++ ++ + +LS+ ++D+ HK + ++ EFK+ I F
Sbjct: 13 RNVVSKKRIRYKEKGYDLDLTYINDNIIAMGYPAPDKLEGLFRNRLEDVFKLLEENHAQHYKIYNLCSERSYDVAKFRGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKKSADEALAWYDEKRT-----KDRKGVTIPSQRRYVQYFSKLVCS---SVPYSKVSLNVCEIRFSESSCVQNLGMVECSISVLHDSATE----------NAKPDRLKTLPIDFQKSFVLTIK----PSIPVSGDVK-FELTKKSP---DKIICHFWLNTFFVRNYSPCESDGTVNKYIH---------------TLSKSEIDDVHKDSEHKRFSEEFKISIVF 334
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Fly
Match: Pten (gene:FBgn0026379 transcript:FBtr0300562) HSP 1 Score: 173.326 bits (438), Expect = 4.260e-47 Identity = 116/363 (31.96%), Postives = 179/363 (49.31%), Query Frame = 2
Query: 599 RHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSG-FTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKL-LKIEKIEITGAQKFYCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDY---RSDVSLLQFAYQCPTIIINCHFLFRLSLSREQLDNPHKKTTWNIYNSEFKVDIFF 1672
R+V S+ + R++ GYDLDL Y+ D +IAM +P+ L+RN + DV K + +YKIYNLC ER+YD F +V Y DHN P +E I F WL + N++AVHCK GKGRTGTMIC +L+ SG+ +A+ L ++ ++RT K +GV PSQ RYV YF + S +P K+ L + +I + + E S+ + + + P + + K +LTI P++ +K F KK P DK FW +T F+ +Y SD ++ ++ + +LS+ ++D+ HK + ++ EFK+ I F
Sbjct: 13 RNVVSKKRIRYKEKGYDLDLTYINDNIIAMGYPAPDKLEGLFRNRLEDVFKLLEENHAQHYKIYNLCSERSYDVAKFRGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKKSADEALAWYDEKRT-----KDRKGVTIPSQRRYVQYFSKLVCS---SVPYSKVSLNVCEIRFSESSCVQNLGMVECSISVLHDSATE----------NAKPDRLKTLPIDFQKSFVLTIK----PSIPVSGDVK-FELTKKSP---DKIICHFWLNTFFVRNYSPCESDGTVNKYIH---------------TLSKSEIDDVHKDSEHKRFSEEFKISIVF 334
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Fly
Match: Pten (gene:FBgn0026379 transcript:FBtr0301521) HSP 1 Score: 173.326 bits (438), Expect = 4.260e-47 Identity = 116/363 (31.96%), Postives = 179/363 (49.31%), Query Frame = 2
Query: 599 RHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSG-FTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKL-LKIEKIEITGAQKFYCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDY---RSDVSLLQFAYQCPTIIINCHFLFRLSLSREQLDNPHKKTTWNIYNSEFKVDIFF 1672
R+V S+ + R++ GYDLDL Y+ D +IAM +P+ L+RN + DV K + +YKIYNLC ER+YD F +V Y DHN P +E I F WL + N++AVHCK GKGRTGTMIC +L+ SG+ +A+ L ++ ++RT K +GV PSQ RYV YF + S +P K+ L + +I + + E S+ + + + P + + K +LTI P++ +K F KK P DK FW +T F+ +Y SD ++ ++ + +LS+ ++D+ HK + ++ EFK+ I F
Sbjct: 13 RNVVSKKRIRYKEKGYDLDLTYINDNIIAMGYPAPDKLEGLFRNRLEDVFKLLEENHAQHYKIYNLCSERSYDVAKFRGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKKSADEALAWYDEKRT-----KDRKGVTIPSQRRYVQYFSKLVCS---SVPYSKVSLNVCEIRFSESSCVQNLGMVECSISVLHDSATE----------NAKPDRLKTLPIDFQKSFVLTIK----PSIPVSGDVK-FELTKKSP---DKIICHFWLNTFFVRNYSPCESDGTVNKYIH---------------TLSKSEIDDVHKDSEHKRFSEEFKISIVF 334
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Fly
Match: Pten (gene:FBgn0026379 transcript:FBtr0089900) HSP 1 Score: 173.326 bits (438), Expect = 4.260e-47 Identity = 116/363 (31.96%), Postives = 179/363 (49.31%), Query Frame = 2
Query: 599 RHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSG-FTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKL-LKIEKIEITGAQKFYCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDY---RSDVSLLQFAYQCPTIIINCHFLFRLSLSREQLDNPHKKTTWNIYNSEFKVDIFF 1672
R+V S+ + R++ GYDLDL Y+ D +IAM +P+ L+RN + DV K + +YKIYNLC ER+YD F +V Y DHN P +E I F WL + N++AVHCK GKGRTGTMIC +L+ SG+ +A+ L ++ ++RT K +GV PSQ RYV YF + S +P K+ L + +I + + E S+ + + + P + + K +LTI P++ +K F KK P DK FW +T F+ +Y SD ++ ++ + +LS+ ++D+ HK + ++ EFK+ I F
Sbjct: 13 RNVVSKKRIRYKEKGYDLDLTYINDNIIAMGYPAPDKLEGLFRNRLEDVFKLLEENHAQHYKIYNLCSERSYDVAKFRGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKKSADEALAWYDEKRT-----KDRKGVTIPSQRRYVQYFSKLVCS---SVPYSKVSLNVCEIRFSESSCVQNLGMVECSISVLHDSATE----------NAKPDRLKTLPIDFQKSFVLTIK----PSIPVSGDVK-FELTKKSP---DKIICHFWLNTFFVRNYSPCESDGTVNKYIH---------------TLSKSEIDDVHKDSEHKRFSEEFKISIVF 334
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Fly
Match: Pten (gene:FBgn0026379 transcript:FBtr0089904) HSP 1 Score: 173.326 bits (438), Expect = 4.260e-47 Identity = 116/363 (31.96%), Postives = 179/363 (49.31%), Query Frame = 2
Query: 599 RHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSG-FTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKL-LKIEKIEITGAQKFYCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDY---RSDVSLLQFAYQCPTIIINCHFLFRLSLSREQLDNPHKKTTWNIYNSEFKVDIFF 1672
R+V S+ + R++ GYDLDL Y+ D +IAM +P+ L+RN + DV K + +YKIYNLC ER+YD F +V Y DHN P +E I F WL + N++AVHCK GKGRTGTMIC +L+ SG+ +A+ L ++ ++RT K +GV PSQ RYV YF + S +P K+ L + +I + + E S+ + + + P + + K +LTI P++ +K F KK P DK FW +T F+ +Y SD ++ ++ + +LS+ ++D+ HK + ++ EFK+ I F
Sbjct: 13 RNVVSKKRIRYKEKGYDLDLTYINDNIIAMGYPAPDKLEGLFRNRLEDVFKLLEENHAQHYKIYNLCSERSYDVAKFRGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKKSADEALAWYDEKRT-----KDRKGVTIPSQRRYVQYFSKLVCS---SVPYSKVSLNVCEIRFSESSCVQNLGMVECSISVLHDSATE----------NAKPDRLKTLPIDFQKSFVLTIK----PSIPVSGDVK-FELTKKSP---DKIICHFWLNTFFVRNYSPCESDGTVNKYIH---------------TLSKSEIDDVHKDSEHKRFSEEFKISIVF 334
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Zebrafish
Match: tpte (transmembrane phosphatase with tensin homology [Source:ZFIN;Acc:ZDB-GENE-030131-5503]) HSP 1 Score: 331.257 bits (848), Expect = 1.379e-106 Identity = 180/452 (39.82%), Postives = 267/452 (59.07%), Query Frame = 2
Query: 332 LDYLAFGFSCIFLIEIILRLHGIGIKTYFCNWINLVDFLVVFVTSVISIV----DITLETSTXXXXXXXXXXXXXXXXXXXXXXNYKKFI-KSSRHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDYRSDVSLLQFAYQCPTIIINCHFLFRLSLSREQLDNPHKKTTWNIYNSEFKVDIFF 1672
L+ ++ S FLI+++LR++ G K YF + +N+VD +V +T V++++ D + + L L + L + K+ + K +R + SENKRR+Q G+DLDL YVT+RVIAMSFPSSG ALYRN I +V +F ++K+ +YK++NLC E+ YD K F+ +VER M+ DHNVP L+++L + R+W+ +N+IA+HCKGGKGRTGTM+C LIDS F++A+ L YFG+RRTD KFQGVETPSQ+RYVGY+E +K + ++P K LKI+ I I + S++ L+I ++ ++ + C V D S + + I + D P + DVK+ F + +P+ Y+ C F+FWF+T F+E+Y RL LSRE+LDNPHK TW+IY +F V + F
Sbjct: 90 LETVSLVISFFFLIDVLLRVYVEGFKVYFSSKLNIVDACIVVITLVVTMIYAFSDFSGASLIPRVVTFLRSLRILILVRIFRLASQKRELEKVTRRMVSENKRRYQKDGFDLDLTYVTERVIAMSFPSSGKQALYRNPIREVVRFLDTKHMDHYKVFNLCSEKGYDPKFFHYRVERVMIDDHNVPSLDDMLRYTACVRDWMAADSRNVIAIHCKGGKGRTGTMVCTWLIDSDQFESAQESLDYFGERRTDKSMSSKFQGVETPSQSRYVGYYEIMKNQYNRQLPPRKSLKIKSIRIHSIAGVGKGNGSDLKLKII------VKHELVFQCVCAKQHNCTVFPDTGS--NAVVISLQDGPIVTGDVKV-MFESSAGLPKGYEDCPFYFWFNTSFVENY------------------------RLFLSREELDNPHKPKTWDIYKEDFGVTLSF 508
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Zebrafish
Match: tpte (transmembrane phosphatase with tensin homology [Source:ZFIN;Acc:ZDB-GENE-030131-5503]) HSP 1 Score: 331.257 bits (848), Expect = 1.379e-106 Identity = 180/452 (39.82%), Postives = 267/452 (59.07%), Query Frame = 2
Query: 332 LDYLAFGFSCIFLIEIILRLHGIGIKTYFCNWINLVDFLVVFVTSVISIV----DITLETSTXXXXXXXXXXXXXXXXXXXXXXNYKKFI-KSSRHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDYRSDVSLLQFAYQCPTIIINCHFLFRLSLSREQLDNPHKKTTWNIYNSEFKVDIFF 1672
L+ ++ S FLI+++LR++ G K YF + +N+VD +V +T V++++ D + + L L + L + K+ + K +R + SENKRR+Q G+DLDL YVT+RVIAMSFPSSG ALYRN I +V +F ++K+ +YK++NLC E+ YD K F+ +VER M+ DHNVP L+++L + R+W+ +N+IA+HCKGGKGRTGTM+C LIDS F++A+ L YFG+RRTD KFQGVETPSQ+RYVGY+E +K + ++P K LKI+ I I + S++ L+I ++ ++ + C V D S + + I + D P + DVK+ F + +P+ Y+ C F+FWF+T F+E+Y RL LSRE+LDNPHK TW+IY +F V + F
Sbjct: 90 LETVSLVISFFFLIDVLLRVYVEGFKVYFSSKLNIVDACIVVITLVVTMIYAFSDFSGASLIPRVVTFLRSLRILILVRIFRLASQKRELEKVTRRMVSENKRRYQKDGFDLDLTYVTERVIAMSFPSSGKQALYRNPIREVVRFLDTKHMDHYKVFNLCSEKGYDPKFFHYRVERVMIDDHNVPSLDDMLRYTACVRDWMAADSRNVIAIHCKGGKGRTGTMVCTWLIDSDQFESAQESLDYFGERRTDKSMSSKFQGVETPSQSRYVGYYEIMKNQYNRQLPPRKSLKIKSIRIHSIAGVGKGNGSDLKLKII------VKHELVFQCVCAKQHNCTVFPDTGS--NAVVISLQDGPIVTGDVKV-MFESSAGLPKGYEDCPFYFWFNTSFVENY------------------------RLFLSREELDNPHKPKTWDIYKEDFGVTLSF 508
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Zebrafish
Match: ptenb (phosphatase and tensin homolog B [Source:ZFIN;Acc:ZDB-GENE-030616-47]) HSP 1 Score: 181.03 bits (458), Expect = 8.985e-51 Identity = 119/372 (31.99%), Postives = 190/372 (51.08%), Query Frame = 2
Query: 599 RHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQGYS---EDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCP---TLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDYRSDVSLLQF--------AYQCPTIIINCHFLFRLSLSREQLDNPHKKTTWNIYNSEFKVDIFF 1672
+ S NKRR+Q G+DLDL Y+ +IAM FP+ +YRN+I DV +F +SK+ +YKIYNLC ER YDT FN +V +Y +DHN P+LE I F + +WL+++D ++ A+HCK GKGRTG MIC +L+ G F A+ L ++ + RT + +GV PSQ RYV Y+ + ++ K+E + K E ++ +F G + + + ++ ++++ +P+ + +E K M + P + D+K++FF K K+ +K + F FW +T FI ++ Q N L+LS+ LD +K ++ FKV +FF
Sbjct: 6 KEFVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKDHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDKWLSENDNHVAAIHCKAGKGRTGVMICAYLLHRGKFKKAQEALDFYDEVRT-----RDKKGVTIPSQRRYVYYYSYLLRN--------------KLEYKPVALLFHKMVFE-TVPMFSGGTCNPQFVVYQLKVKIHTSNPAHTR----REEK-----YMFFEFPQPLPVCGDIKVEFFHKQNKMMKK--EKMFHFWVNTFFIPGSEESTEKVENGGLVKDLDGIQTAERGENDKDYLILTLSKTDLDKANKDKANRYFSPNFKVKMFF 346
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Zebrafish
Match: ptena (phosphatase and tensin homolog A [Source:ZFIN;Acc:ZDB-GENE-030131-3776]) HSP 1 Score: 179.874 bits (455), Expect = 4.443e-50 Identity = 109/312 (34.94%), Postives = 172/312 (55.13%), Query Frame = 2
Query: 599 RHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFE-TIKKSPDFKIPNGKLLK------IEKIEITGAQKFYCKSESEISLQIFQGYS-----EDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFI 1498
+ + S NKRR+Q G+DLDL Y+ +IAM FP+ +YRN+I DV +F +SK+ +YKIYNLC ER YD FN +V +Y +DHN P+LE I F + +WL++ + ++ A+HCK GKGRTG MIC +L+ F A+ L ++G+ RT + +GV PSQ RYV Y+ +K D+K P L + + K+ SE++ Q F+ S + + ++ ++++ +P+ + ++H++ P D+K++FF K K+ +K DK F FW +T FI
Sbjct: 6 KEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDASKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDENHVAAIHCKAGKGRTGVMICAYLLHRKKFAEAQEALDFYGEVRT-----RDKKGVTIPSQRRYVYYYSYLLKNKLDYK-PVALLFHKMVFQTLPMFSGGTCRDSTVKNRSEVNPQGFKKGSWHWDPQFVVYQLKVKIHTSNPAHT-----RREEKHMIFEFPQPLPVC-GDIKVEFFHKQSKMMKK-DKM-FHFWINTFFI 303
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Zebrafish
Match: ptena (phosphatase and tensin homolog A [Source:ZFIN;Acc:ZDB-GENE-030131-3776]) HSP 1 Score: 179.874 bits (455), Expect = 4.443e-50 Identity = 109/312 (34.94%), Postives = 172/312 (55.13%), Query Frame = 2
Query: 599 RHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFE-TIKKSPDFKIPNGKLLK------IEKIEITGAQKFYCKSESEISLQIFQGYS-----EDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFI 1498
+ + S NKRR+Q G+DLDL Y+ +IAM FP+ +YRN+I DV +F +SK+ +YKIYNLC ER YD FN +V +Y +DHN P+LE I F + +WL++ + ++ A+HCK GKGRTG MIC +L+ F A+ L ++G+ RT + +GV PSQ RYV Y+ +K D+K P L + + K+ SE++ Q F+ S + + ++ ++++ +P+ + ++H++ P D+K++FF K K+ +K DK F FW +T FI
Sbjct: 6 KEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDASKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDENHVAAIHCKAGKGRTGVMICAYLLHRKKFAEAQEALDFYGEVRT-----RDKKGVTIPSQRRYVYYYSYLLKNKLDYK-PVALLFHKMVFQTLPMFSGGTCRDSTVKNRSEVNPQGFKKGSWHWDPQFVVYQLKVKIHTSNPAHT-----RREEKHMIFEFPQPLPVC-GDIKVEFFHKQSKMMKK-DKM-FHFWINTFFI 303
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Xenopus
Match: tpte2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 [Source:NCBI gene;Acc:548705]) HSP 1 Score: 311.227 bits (796), Expect = 1.636e-99 Identity = 171/438 (39.04%), Postives = 257/438 (58.68%), Query Frame = 2
Query: 374 EIILRLHGIGIKTYFCNWINLVDFLVVFVTSVISIV----DITLETSTXXXXXXXXXXXXXXXXXXXXXXNYKKFI-KSSRHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDYRSDVSLLQFAYQCPTIIINCHFLFRLSLSREQLDNPHKKTTWNIYNSEFKVDIFF 1672
+++L + G + YF + +N+ D ++V VT ++++V D + ++ L + I L L + K+ + K +R + SENKRR+Q G+DLDL Y+TDR+IAMSFPSSG + YRN I +VA+F +SK+ +YKIYNLC E+ YD K F+ +VER + DHNVP L ++L F S R W+ + QN+IA+HCKGGKGRTGTM+C +L+DS F++A L YFG+RRTD KFQGVETPSQ+RYV Y+E +K ++P K LKI I I Q + +++ +QI +++ ++ + C++ D + + + I + CP + D+KI+ F + +P+ YD CAF+FWF+T FIE+ RL LS+ +LDNPHK+ + IY F V++ F
Sbjct: 45 DVLLHIFVEGFRQYFSSKLNIFDAVIVIVTLLVTLVYAFTDFSGASNIPRMVNFLRALRIIILIRILRLASQKRQLEKVTRRLVSENKRRYQKDGFDLDLTYITDRIIAMSFPSSGKQSFYRNPIEEVARFLDSKHQDHYKIYNLCSEKGYDPKYFHYRVERVFIDDHNVPVLADMLTFTASVRAWMAEDPQNVIAIHCKGGKGRTGTMVCTYLVDSDQFESAVESLDYFGERRTDTSVSTKFQGVETPSQSRYVAYYEVLKNKFSRQLPPEKQLKIRSIRIYSIQGVGRSNGTDLKVQII------MKKEVVFQCVCETQGNCKLFFD--AGNNSIVISLDGCPVISGDIKIR-FESSANIPKGYDDCAFYFWFNTSFIENS------------------------RLYLSKNELDNPHKEKSGKIYKENFAVELNF 449
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Xenopus
Match: tpte2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 [Source:NCBI gene;Acc:548705]) HSP 1 Score: 311.227 bits (796), Expect = 3.194e-99 Identity = 171/438 (39.04%), Postives = 257/438 (58.68%), Query Frame = 2
Query: 374 EIILRLHGIGIKTYFCNWINLVDFLVVFVTSVISIV----DITLETSTXXXXXXXXXXXXXXXXXXXXXXNYKKFI-KSSRHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDYRSDVSLLQFAYQCPTIIINCHFLFRLSLSREQLDNPHKKTTWNIYNSEFKVDIFF 1672
+++L + G + YF + +N+ D ++V VT ++++V D + ++ L + I L L + K+ + K +R + SENKRR+Q G+DLDL Y+TDR+IAMSFPSSG + YRN I +VA+F +SK+ +YKIYNLC E+ YD K F+ +VER + DHNVP L ++L F S R W+ + QN+IA+HCKGGKGRTGTM+C +L+DS F++A L YFG+RRTD KFQGVETPSQ+RYV Y+E +K ++P K LKI I I Q + +++ +QI +++ ++ + C++ D + + + I + CP + D+KI+ F + +P+ YD CAF+FWF+T FIE+ RL LS+ +LDNPHK+ + IY F V++ F
Sbjct: 66 DVLLHIFVEGFRQYFSSKLNIFDAVIVIVTLLVTLVYAFTDFSGASNIPRMVNFLRALRIIILIRILRLASQKRQLEKVTRRLVSENKRRYQKDGFDLDLTYITDRIIAMSFPSSGKQSFYRNPIEEVARFLDSKHQDHYKIYNLCSEKGYDPKYFHYRVERVFIDDHNVPVLADMLTFTASVRAWMAEDPQNVIAIHCKGGKGRTGTMVCTYLVDSDQFESAVESLDYFGERRTDTSVSTKFQGVETPSQSRYVAYYEVLKNKFSRQLPPEKQLKIRSIRIYSIQGVGRSNGTDLKVQII------MKKEVVFQCVCETQGNCKLFFD--AGNNSIVISLDGCPVISGDIKIR-FESSANIPKGYDDCAFYFWFNTSFIENS------------------------RLYLSKNELDNPHKEKSGKIYKENFAVELNF 470
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Xenopus
Match: tpte2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 [Source:NCBI gene;Acc:548705]) HSP 1 Score: 311.227 bits (796), Expect = 9.781e-99 Identity = 171/438 (39.04%), Postives = 257/438 (58.68%), Query Frame = 2
Query: 374 EIILRLHGIGIKTYFCNWINLVDFLVVFVTSVISIV----DITLETSTXXXXXXXXXXXXXXXXXXXXXXNYKKFI-KSSRHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDYRSDVSLLQFAYQCPTIIINCHFLFRLSLSREQLDNPHKKTTWNIYNSEFKVDIFF 1672
+++L + G + YF + +N+ D ++V VT ++++V D + ++ L + I L L + K+ + K +R + SENKRR+Q G+DLDL Y+TDR+IAMSFPSSG + YRN I +VA+F +SK+ +YKIYNLC E+ YD K F+ +VER + DHNVP L ++L F S R W+ + QN+IA+HCKGGKGRTGTM+C +L+DS F++A L YFG+RRTD KFQGVETPSQ+RYV Y+E +K ++P K LKI I I Q + +++ +QI +++ ++ + C++ D + + + I + CP + D+KI+ F + +P+ YD CAF+FWF+T FIE+ RL LS+ +LDNPHK+ + IY F V++ F
Sbjct: 103 DVLLHIFVEGFRQYFSSKLNIFDAVIVIVTLLVTLVYAFTDFSGASNIPRMVNFLRALRIIILIRILRLASQKRQLEKVTRRLVSENKRRYQKDGFDLDLTYITDRIIAMSFPSSGKQSFYRNPIEEVARFLDSKHQDHYKIYNLCSEKGYDPKYFHYRVERVFIDDHNVPVLADMLTFTASVRAWMAEDPQNVIAIHCKGGKGRTGTMVCTYLVDSDQFESAVESLDYFGERRTDTSVSTKFQGVETPSQSRYVAYYEVLKNKFSRQLPPEKQLKIRSIRIYSIQGVGRSNGTDLKVQII------MKKEVVFQCVCETQGNCKLFFD--AGNNSIVISLDGCPVISGDIKIR-FESSANIPKGYDDCAFYFWFNTSFIENS------------------------RLYLSKNELDNPHKEKSGKIYKENFAVELNF 507
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Xenopus
Match: tpte2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 [Source:NCBI gene;Acc:548705]) HSP 1 Score: 274.633 bits (701), Expect = 7.484e-85 Identity = 160/438 (36.53%), Postives = 244/438 (55.71%), Query Frame = 2
Query: 374 EIILRLHGIGIKTYFCNWINLVDFLVVFVTSVISIV----DITLETSTXXXXXXXXXXXXXXXXXXXXXXNYKKFI-KSSRHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDYRSDVSLLQFAYQCPTIIINCHFLFRLSLSREQLDNPHKKTTWNIYNSEFKVDIFF 1672
+++L + G + YF + +N+ D ++V VT ++++V D + ++ L + I L L + K+ + K +R + SENKRR+Q G+DLDL Y+TDR+IAMSFPSSG + YRN I + + +CE + YD K F+ +VER + DHNVP L ++L F S R W+ + QN+IA+HCKGGKGRTGTM+C +L+DS F++A L YFG+RRTD KFQGVETPSQ+RYV Y+E +K ++P K LKI I I Q + +++ +QI +++ ++ + C++ D + + + I + CP + D+KI+ F + +P+ YD CAF+FWF+T FIE+ RL LS+ +LDNPHK+ + IY F V++ F
Sbjct: 99 DVLLHIFVEGFRQYFSSKLNIFDAVIVIVTLLVTLVYAFTDFSGASNIPRMVNFLRALRIIILIRILRLASQKRQLEKVTRRLVSENKRRYQKDGFDLDLTYITDRIIAMSFPSSGKQSFYRNPIEVYL----------HMAFRICE-KGYDPKYFHYRVERVFIDDHNVPVLADMLTFTASVRAWMAEDPQNVIAIHCKGGKGRTGTMVCTYLVDSDQFESAVESLDYFGERRTDTSVSTKFQGVETPSQSRYVAYYEVLKNKFSRQLPPEKQLKIRSIRIYSIQGVGRSNGTDLKVQII------MKKEVVFQCVCETQGNCKLFFD--AGNNSIVISLDGCPVISGDIKIR-FESSANIPKGYDDCAFYFWFNTSFIENS------------------------RLYLSKNELDNPHKEKSGKIYKENFAVELNF 492
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Xenopus
Match: tpte2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 [Source:NCBI gene;Acc:548705]) HSP 1 Score: 239.965 bits (611), Expect = 1.955e-71 Identity = 126/321 (39.25%), Postives = 184/321 (57.32%), Query Frame = 2
Query: 710 TALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDYRSDVSLLQFAYQCPTIIINCHFLFRLSLSREQLDNPHKKTTWNIYNSEFKVDIFF 1672
T Y +VA+F +SK+ +YKIYNLC E+ YD K F+ +VER + DHNVP L ++L F S R W+ + QN+IA+HCKGGKGRTGTM+C +L+DS F++A L YFG+RRTD KFQGVETPSQ+RYV Y+E +K ++P K LKI I I Q + +++ +QI +++ ++ + C++ D + + + I + CP + D+KI+ F + +P+ YD CAF+FWF+T FIE+ RL LS+ +LDNPHK+ + IY F V++ F
Sbjct: 222 TEFYHLFSQEVARFLDSKHQDHYKIYNLCSEKGYDPKYFHYRVERVFIDDHNVPVLADMLTFTASVRAWMAEDPQNVIAIHCKGGKGRTGTMVCTYLVDSDQFESAVESLDYFGERRTDTSVSTKFQGVETPSQSRYVAYYEVLKNKFSRQLPPEKQLKIRSIRIYSIQGVGRSNGTDLKVQII------MKKEVVFQCVCETQGNCKLFFD--AGNNSIVISLDGCPVISGDIKIR-FESSANIPKGYDDCAFYFWFNTSFIENS------------------------RLYLSKNELDNPHKEKSGKIYKENFAVELNF 509
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Mouse
Match: Tpte (transmembrane phosphatase with tensin homology [Source:MGI Symbol;Acc:MGI:2446460]) HSP 1 Score: 302.753 bits (774), Expect = 7.248e-94 Identity = 176/454 (38.77%), Postives = 262/454 (57.71%), Query Frame = 2
Query: 332 LDY--LAFGFSCIFLIEIILRLHGIGIKTYFCNWINLVDFLVVFVTSVI----SIVDITLETSTXXXXXXXXXXXXXXXXXXXXXXNYKKFIKS-SRHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDYRSDVSLLQFAYQCPTIIINCHFLFRLSLSREQLDNPHKKTTWNIYNSEFKVDIFF 1672
LDY ++ + FL++++LR+ G + YF + +N +D +V+ VT V+ ++ D ++ L L I L L + K+ ++ +R + S NKRR++ G+DLDL YVT+R+IAMSFPSSG + YRN I +V +F ++K+ +Y++YNLC ERAYD K F+ +V R M+ DHNVP LEE+L F+K W+ + +N++A+HCKGGKGRTGTM+C LI S + NA+ L +FG+RRTD KFQG+ETPSQNRYV YFE +K + +P K+L I+++ + S++ +QI + E + + + C + D E+ + I + CP L+DDVK+KF + N +P+ YD C FFFWFHT FI++ RL L R +LDN HK TW IY +F V++ F
Sbjct: 244 LDYRSISLAIALFFLVDVLLRVSVEGRRRYFSDVLNTLDAVVIGVTVVVAVIYALYDKHFLRDIPRLAVLLRPLRLLILIRILQLAHQKRQLERLTRKLVSGNKRRYKKDGFDLDLTYVTERIIAMSFPSSGRESFYRNPIKEVVRFLDTKHPNHYQVYNLCSERAYDPKHFHYRVRRIMIDDHNVPTLEEMLLFSKEVNNWMAQDPENVVAIHCKGGKGRTGTMVCACLIASEIVLNAKESLYFFGERRTDKSNSSKFQGIETPSQNRYVKYFEKLKINYQLTLPPKKVLVIKRLVVYSIHGVGKGDGSDLEVQIIM-WQETV-------FSFCNSRNCMIFHDPETDRAI--INVFHCPALYDDVKVKFLSPN--LPKYYDDCPFFFWFHTSFIKNN------------------------RLYLPRNELDNTHKPKTWKIYGEKFAVEVDF 661
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Mouse
Match: Tpte (transmembrane phosphatase with tensin homology [Source:MGI Symbol;Acc:MGI:2446460]) HSP 1 Score: 236.884 bits (603), Expect = 1.398e-69 Identity = 132/316 (41.77%), Postives = 199/316 (62.97%), Query Frame = 2
Query: 332 LDY--LAFGFSCIFLIEIILRLHGIGIKTYFCNWINLVDFLVVFVTSVI----SIVDITLETSTXXXXXXXXXXXXXXXXXXXXXXNYKKFIKS-SRHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQI 1258
LDY ++ + FL++++LR+ G + YF + +N +D +V+ VT V+ ++ D ++ L L I L L + K+ ++ +R + S NKRR++ G+DLDL YVT+R+IAMSFPSSG + YRN I +V +F ++K+ +Y++YNLC ERAYD K F+ +V R M+ DHNVP LEE+L F+K W+ + +N++A+HCKGGKGRTGTM+C LI S + NA+ L +FG+RRTD KFQG+ETPSQNRYV YFE +K + +P K+L I+++ + S++ +QI
Sbjct: 244 LDYRSISLAIALFFLVDVLLRVSVEGRRRYFSDVLNTLDAVVIGVTVVVAVIYALYDKHFLRDIPRLAVLLRPLRLLILIRILQLAHQKRQLERLTRKLVSGNKRRYKKDGFDLDLTYVTERIIAMSFPSSGRESFYRNPIKEVVRFLDTKHPNHYQVYNLCSERAYDPKHFHYRVRRIMIDDHNVPTLEEMLLFSKEVNNWMAQDPENVVAIHCKGGKGRTGTMVCACLIASEIVLNAKESLYFFGERRTDKSNSSKFQGIETPSQNRYVKYFEKLKINYQLTLPPKKVLVIKRLVVYSIHGVGKGDGSDLEVQI 559
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Mouse
Match: Pten (phosphatase and tensin homolog [Source:MGI Symbol;Acc:MGI:109583]) HSP 1 Score: 181.8 bits (460), Expect = 5.201e-51 Identity = 122/371 (32.88%), Postives = 191/371 (51.48%), Query Frame = 2
Query: 599 RHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFE-TIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCP---TLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDYRSDVSLLQFAYQCPTIIINCHFLFR---------LSLSREQLDNPHKKTTWNIYNSEFKVDIFF 1672
+ + S NKRR+Q G+DLDL Y+ +IAM FP+ +YRN+I DV +F +SK+ +YKIYNLC ER YDT FN +V +Y +DHN P+LE I F + +WL++ D ++ A+HCK GKGRTG MIC +L+ G F A+ L ++G+ RT + +GV PSQ RYV Y+ +K D++ P L E ++ +F G + + + ++ ++ + S + +E K M + P + D+K++FF K K+ +K DK F FW +T FI ++ C I + + R L+L++ LD +K ++ FKV ++F
Sbjct: 6 KEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRT-----RDKKGVTIPSQRRYVYYYSYLLKNHLDYR-PVALLFHKMMFE---------------TIPMFSGGTCN-PQFVVCQLKVKIYSSNSGPTRREDK-----FMYFEFPQPLPVCGDIKVEFFHKQNKMLKK-DK-MFHFWVNTFFIPGPEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYF 347
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Mouse
Match: Tns1 (tensin 1 [Source:MGI Symbol;Acc:MGI:104552]) HSP 1 Score: 112.464 bits (280), Expect = 3.021e-25 Identity = 70/207 (33.82%), Postives = 110/207 (53.14%), Query Frame = 2
Query: 647 DLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQG 1267
+LDL YVT+R+IA+SFPS+ +R+++ +VA+ SK+G NY ++NL E+R TK+ + +V + D + P LE+I K+ WL N++ +H KG +GR G +I +L S + +A+ L F +R K + PSQ RYV YF + S K+ N K L + + + G F K L+I+Q
Sbjct: 139 ELDLVYVTERIIAVSFPSTANEENFRSNLREVAQMLKSKHGGNYLLFNLSEQRPDITKL-HAKVLEFGWPDLHTPALEKICSVCKAMDTWLNADPHNVVVLHNKGNRGRIGVVIAAYLHYSNISASADQALDRFAMKR---FYEDKIVPIGQPSQRRYVHYFSGL-LSGSIKM-NNKPLFLHHVIMHGIPNFESKGGCRPFLRIYQA 339
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Mouse
Match: Tns1 (tensin 1 [Source:MGI Symbol;Acc:MGI:104552]) HSP 1 Score: 112.464 bits (280), Expect = 3.042e-25 Identity = 70/207 (33.82%), Postives = 110/207 (53.14%), Query Frame = 2
Query: 647 DLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQG 1267
+LDL YVT+R+IA+SFPS+ +R+++ +VA+ SK+G NY ++NL E+R TK+ + +V + D + P LE+I K+ WL N++ +H KG +GR G +I +L S + +A+ L F +R K + PSQ RYV YF + S K+ N K L + + + G F K L+I+Q
Sbjct: 183 ELDLVYVTERIIAVSFPSTANEENFRSNLREVAQMLKSKHGGNYLLFNLSEQRPDITKL-HAKVLEFGWPDLHTPALEKICSVCKAMDTWLNADPHNVVVLHNKGNRGRIGVVIAAYLHYSNISASADQALDRFAMKR---FYEDKIVPIGQPSQRRYVHYFSGL-LSGSIKM-NNKPLFLHHVIMHGIPNFESKGGCRPFLRIYQA 383
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. UniProt/SwissProt
Match: sp|Q6XPS3|TPTE2_HUMAN (Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 OS=Homo sapiens OX=9606 GN=TPTE2 PE=1 SV=2) HSP 1 Score: 319.701 bits (818), Expect = 4.200e-101 Identity = 173/449 (38.53%), Postives = 261/449 (58.13%), Query Frame = 2
Query: 341 LAFGFSCIFLIEIILRLHGIGIKTYFCNWINLVDFLVVFVTSVISIV----DITLETSTXXXXXXXXXXXXXXXXXXXXXXNYKKFI-KSSRHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDYRSDVSLLQFAYQCPTIIINCHFLFRLSLSREQLDNPHKKTTWNIYNSEFKVDIFF 1672
++ FL++++LR+ G + YF + N++D ++ + ++ ++ DI L + + L + I L + K+ + K R + SENKRR+ G+DLDL YVT+R+IAMSFPSSG + YRN I +V +F + K+ +Y++YNLC ERAYD K F+++V R M+ DHNVP L E++ F K EW+ + +NI+A+HCKGGKGRTGTM+C LI S +F AE L YFG+RRT+ KFQGVETPSQNRYVGYF +K ++ +P ++L I++ I + C + ++ ++ ++ + +LG+ C + D E+ + + I + D P L+DDVK++FF+ N +P+ YD C FFFWF+T FI++ RL L R +LDNPHK+ W IY EF V+I F
Sbjct: 111 ISLAIGLFFLMDVLLRVFVEGRQQYFSDLFNILDTAIIVIPLLVDVIYIFFDIKLLRNIPRWTHLVRLLRLIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVME---------KKVVFSSTSLGN---CSILHDIETDK--ILINVYDGPPLYDDVKVQFFSSN--LPKYYDNCPFFFWFNTSFIQNN------------------------RLCLPRNELDNPHKQKAWKIYPPEFAVEILF 519
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. UniProt/SwissProt
Match: sp|Q4R6N0|TPTE2_MACFA (Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 OS=Macaca fascicularis OX=9541 GN=TPTE2 PE=2 SV=1) HSP 1 Score: 293.893 bits (751), Expect = 1.317e-90 Identity = 159/397 (40.05%), Postives = 238/397 (59.95%), Query Frame = 2
Query: 341 LAFGFSCIFLIEIILRLHGIGIKTYFCNWINLVDFLVVFVTSVISIV----DITLETSTXXXXXXXXXXXXXXXXXXXXXXNYKKFI-KSSRHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQGYSEDIRERMII--EMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDYR 1510
++ + FL++++LR+ G + YF + +N++D ++ ++ +V DI + + L + I L + K+ + K R + SENKRR+ G+DLDL YVT+R+IAMSFPSSG + YRN I +V +F + K+ +Y++YNLC ERAYD K F+++V R M+ DHNVP L E++ F K EW+ + NI+A+HCKGGKGRTGTMIC LI S +F AE L YFG+RRTD KFQGVETPSQNRYVGYF +K ++ +P ++L I++ I + ++ ++I + E+ ++ +LG+ C + D E+ L I + P L+DDVK++FF+ N +P+ YD C FFFWF+T FI+ R
Sbjct: 173 ISLAIALFFLMDVLLRVFVEGRQHYFSDLLNVLDTAIIVTPLLVDVVYIFFDIKFLRNIPRWIHLVRLLRLIILIRIFHLIHQKRELEKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHPNHYRVYNLCSERAYDPKYFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDPANIVAIHCKGGKGRTGTMICAFLIASEIFLTAEESLYYFGERRTDKTNSSKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFIIYSIRGVGTGGVCDLKVRI-------VMEKKVVFSSTSLGN---CSILHDIETDRVL--IDVFSGPPLYDDVKVQFFSSN--LPKYYDNCPFFFWFNTSFIQSNR 555
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. UniProt/SwissProt
Match: sp|P56180|TPTE_HUMAN (Putative tyrosine-protein phosphatase TPTE OS=Homo sapiens OX=9606 GN=TPTE PE=1 SV=3) HSP 1 Score: 283.108 bits (723), Expect = 1.233e-86 Identity = 164/453 (36.20%), Postives = 252/453 (55.63%), Query Frame = 2
Query: 341 LAFGFSCIFLIEIILRLHGIGIKTYFCNWINLVDFLVVFVTSVISIV----DITLETSTXXXXXXXXXXXXXXXXXXXXXXNYKKFI-KSSRHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQV----TSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDYRSDVSLLQFAYQCPTIIINCHFLFRLSLSREQLDNPHKKTTWNIYNSEFKVDIFF 1672
++ + FL++++LR+ + YF + N++D ++ + ++ +V DI L + + L + + L + K+ + K R SENKRR+ G+DLDL YVT+R+IAMSFPSSG + YRN I +V +F + K+ +Y++YNLC ERAYD K F+++V R M+ DHNVP L +++ F K EW+ + +NI+A+HCKGG RTGTM+C LI S + A+ L YFG+RRTD +KFQGV+TPSQ RYV YF +K ++ +P ++L I+ I ++ + +I ++ ++ + ++LG KC V T+DK + I + D L+DDVK++FF N +P YD C+F+FW HT FIE+ RL L + +LDN HK+ IY S+F V+I F
Sbjct: 129 ISLAIALFFLMDVLLRVFVERRQQYFSDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLLRLIILLRIFHLFHQKRQLEKLIRRRVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLIASEICSTAKESLYYFGERRTDKTHSEKFQGVKTPSQKRYVAYFAQVKHLYNWNLPPRRILFIKHFIIYSIPRYVRDLKIQIEME---------KKVVFSTISLG---KCSVLDNITTDK------ILIDVFDGLPLYDDVKVQFFYSN--LPTYYDNCSFYFWLHTSFIENN------------------------RLYLPKNELDNLHKQKARRIYPSDFAVEILF 537
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. UniProt/SwissProt
Match: sp|O08586|PTEN_MOUSE (Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Mus musculus OX=10090 GN=Pten PE=1 SV=1) HSP 1 Score: 181.8 bits (460), Expect = 3.638e-50 Identity = 122/371 (32.88%), Postives = 191/371 (51.48%), Query Frame = 2
Query: 599 RHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFE-TIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCP---TLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDYRSDVSLLQFAYQCPTIIINCHFLFR---------LSLSREQLDNPHKKTTWNIYNSEFKVDIFF 1672
+ + S NKRR+Q G+DLDL Y+ +IAM FP+ +YRN+I DV +F +SK+ +YKIYNLC ER YDT FN +V +Y +DHN P+LE I F + +WL++ D ++ A+HCK GKGRTG MIC +L+ G F A+ L ++G+ RT + +GV PSQ RYV Y+ +K D++ P L E ++ +F G + + + ++ ++ + S + +E K M + P + D+K++FF K K+ +K DK F FW +T FI ++ C I + + R L+L++ LD +K ++ FKV ++F
Sbjct: 6 KEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRT-----RDKKGVTIPSQRRYVYYYSYLLKNHLDYR-PVALLFHKMMFE---------------TIPMFSGGTCN-PQFVVCQLKVKIYSSNSGPTRREDK-----FMYFEFPQPLPVCGDIKVEFFHKQNKMLKK-DK-MFHFWVNTFFIPGPEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYF 347
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. UniProt/SwissProt
Match: sp|P60484|PTEN_HUMAN (Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Homo sapiens OX=9606 GN=PTEN PE=1 SV=1) HSP 1 Score: 181.8 bits (460), Expect = 3.909e-50 Identity = 122/371 (32.88%), Postives = 191/371 (51.48%), Query Frame = 2
Query: 599 RHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFE-TIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCP---TLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDYRSDVSLLQFAYQCPTIIINCHFLFR---------LSLSREQLDNPHKKTTWNIYNSEFKVDIFF 1672
+ + S NKRR+Q G+DLDL Y+ +IAM FP+ +YRN+I DV +F +SK+ +YKIYNLC ER YDT FN +V +Y +DHN P+LE I F + +WL++ D ++ A+HCK GKGRTG MIC +L+ G F A+ L ++G+ RT + +GV PSQ RYV Y+ +K D++ P L E ++ +F G + + + ++ ++ + S + +E K M + P + D+K++FF K K+ +K DK F FW +T FI ++ C I + + R L+L++ LD +K ++ FKV ++F
Sbjct: 6 KEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRT-----RDKKGVTIPSQRRYVYYYSYLLKNHLDYR-PVALLFHKMMFE---------------TIPMFSGGTCN-PQFVVCQLKVKIYSSNSGPTRREDK-----FMYFEFPQPLPVCGDIKVEFFHKQNKMLKK-DK-MFHFWVNTFFIPGPEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYF 347
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. TrEMBL
Match: A0A267DMK1 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig032453g1 PE=4 SV=1) HSP 1 Score: 377.867 bits (969), Expect = 2.456e-121 Identity = 194/453 (42.83%), Postives = 283/453 (62.47%), Query Frame = 2
Query: 335 DYLAFGFSCIFLIEIILRLHGIGIKTYFCNWINLVDFLVVFVTSVISIVDI-------TLETSTXXXXXXXXXXXXXXXXXXXXXXNYKKFIKSSRHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDYRSDVSLLQFAYQCPTIIINCHFLFRLSLSREQLDNPHKKTTWNIYNSEFKVDIFF 1672
DY+ +F+IE+ +R+ +G + +F NWI ++DF VV +T ++S+V + T + IRL RL ++ + L K K++RHV S+NK+R++ G+DLDLCY+T++VIAMS+PSSG A+YRN I +VAKF + K+ YK+YNLC ER YD+ F+D+VERY++ DHNVPRL ++++FA S R+WL +QNII VHCKGGKGRTGTMIC +++DS +++NA+ CL +FG +RTD QG KFQGVETPSQNRYVGYFET+KK ++++P L + KI I G S+ +IF+G + + E +LG C +E+ ++T+ + PT+ +DVK FF++N+ VP Y+ CAFFFW +T FI+D ++ L R QLDNPHK TW +++ F V++ F
Sbjct: 84 DYVGLVIVILFVIEVGVRIFALGPEKFFSNWIMVLDFAVVILTFIVSVVFMSVPDLSDTAKLGKLVVLARLIRLPRLVALVRVFLTERKNLTKATRHVVSQNKKRYEDDGFDLDLCYITEKVIAMSYPSSGLMAMYRNPIKEVAKFLDLKHYNRYKVYNLCSERYYDSSFFHDRVERYLIDDHNVPRLSDMVKFANSVRDWLAAHEQNIIVVHCKGGKGRTGTMICTYMVDSDIYENAKECLDFFGLKRTDYQQGIKFQGVETPSQNRYVGYFETVKKEFNYEMPPDTPLIVRKIIIHGISSIGNGDGSDFWFRIFEG------GKQVGEFDLGINKNCMAEFSRETDSAVVTLR--NPPTVLNDVKFSFFSRNRNVPTAYENCAFFFWIYTYFIQD------------------------LKIKLDRTQLDNPHKSKTWKVWHENFAVEVLF 504
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. TrEMBL
Match: A0A267DEJ3 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig032453g2 PE=4 SV=1) HSP 1 Score: 377.096 bits (967), Expect = 4.349e-121 Identity = 194/453 (42.83%), Postives = 283/453 (62.47%), Query Frame = 2
Query: 335 DYLAFGFSCIFLIEIILRLHGIGIKTYFCNWINLVDFLVVFVTSVISIVDI-------TLETSTXXXXXXXXXXXXXXXXXXXXXXNYKKFIKSSRHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDYRSDVSLLQFAYQCPTIIINCHFLFRLSLSREQLDNPHKKTTWNIYNSEFKVDIFF 1672
DY+ +F+IE+ +R+ +G + +F NWI ++DF VV +T ++S+V + T + IRL RL ++ + L K K++RHV S+NK+R++ G+DLDLCY+T++VIAMS+PSSG A+YRN I +VAKF + K+ YK+YNLC ER YD+ F+D+VERY++ DHNVPRL ++++FA S R+WL +QNII VHCKGGKGRTGTMIC +++DS +++NA+ CL +FG +RTD QG KFQGVETPSQNRYVGYFET+KK ++++P L + KI I G S+ +IF+G + + E +LG C +E+ ++T+ + PT+ +DVK FF++N+ VP Y+ CAFFFW +T FI+D ++ L R QLDNPHK TW +++ F V++ F
Sbjct: 84 DYVGLVIVILFVIEVGVRIFALGPEKFFSNWIMVLDFAVVLLTFIVSVVFMSVPDLSDTAKLGKLVVLARLIRLPRLVALVRVFLTERKNLTKATRHVVSQNKKRYEDDGFDLDLCYITEKVIAMSYPSSGLMAMYRNPIKEVAKFLDLKHYNRYKVYNLCSERYYDSSFFHDRVERYLIDDHNVPRLSDMVKFANSVRDWLAAHEQNIIVVHCKGGKGRTGTMICTYMVDSDIYENAKECLDFFGLKRTDYQQGIKFQGVETPSQNRYVGYFETVKKEFNYEMPPDTPLIVRKIIIHGISSIGNGDGSDFWFRIFEG------GKQVGEFDLGINKNCIAEFSRETDSAVVTLR--NPPTVLNDVKFSFFSRNRNVPTAYENCAFFFWIYTYFIQD------------------------LKIKLDRTQLDNPHKSKTWKVWHENFAVEVLF 504
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. TrEMBL
Match: A0A267FVM4 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig032453g3 PE=4 SV=1) HSP 1 Score: 377.096 bits (967), Expect = 5.280e-121 Identity = 194/453 (42.83%), Postives = 282/453 (62.25%), Query Frame = 2
Query: 335 DYLAFGFSCIFLIEIILRLHGIGIKTYFCNWINLVDFLVVFVTSVISIVDI-------TLETSTXXXXXXXXXXXXXXXXXXXXXXNYKKFIKSSRHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDYRSDVSLLQFAYQCPTIIINCHFLFRLSLSREQLDNPHKKTTWNIYNSEFKVDIFF 1672
DY+ +F+IE+ +R+ +G + +F NWI ++DF VV +T ++S+V + T + IRL RL ++ + L K K++RHV S+NK+R++ G+DLDLCY+T++VIAMS+PSSG A+YRN I +VAKF + K+ YK+YNLC ER YD+ F+D+VERY++ DHNVPRL ++++FA S R+WL +QNII VHCKGGKGRTGTMIC +++DS +++NA+ CL +FG +RTD QG KFQGVETPSQNRYVGYFET+KK ++++P L + KI I G S+ +IF+G + + E +LG C +E+ ++T+ + PT+ +DVK FF++N+ VP Y+ CAFFFW +T FI+D ++ L R QLDNPHK TW ++ F V++ F
Sbjct: 84 DYVGLVIVILFVIEVGVRIFALGPEKFFSNWIMVLDFAVVLLTFIVSVVFMSVPDLSDTAKLGKLVVLARLIRLPRLVALVRVFLTERKNLTKATRHVVSQNKKRYEDDGFDLDLCYITEKVIAMSYPSSGLMAMYRNPIKEVAKFLDLKHYNRYKVYNLCSERYYDSSFFHDRVERYLIDDHNVPRLSDMVKFANSVRDWLAAHEQNIIVVHCKGGKGRTGTMICTYMVDSDIYENAKECLDFFGLKRTDYQQGIKFQGVETPSQNRYVGYFETVKKEFNYEMPPDTPLIVRKIIIHGISSIGNGDGSDFWFRIFEGVKQ------VGEFDLGINKNCMAEFSRETDSAVVTLR--NPPTVLNDVKFSFFSRNRNVPTAYENCAFFFWIYTYFIQD------------------------LKIKLDRTQLDNPHKTKTWKAWHENFAVEVLF 504
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. TrEMBL
Match: A0A4Y2BQI5 (Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 OS=Araneus ventricosus OX=182803 GN=TPTE2 PE=4 SV=1) HSP 1 Score: 369.007 bits (946), Expect = 2.741e-117 Identity = 178/452 (39.38%), Postives = 275/452 (60.84%), Query Frame = 2
Query: 317 LDEKELDYLAFGFSCIFLIEIILRLHGIGIKTYFCNWINLVDFLVVFVTSVISIVDITLETSTXXXXXXXXXXXXXXXXXXXXXXNYKKFIKSSRHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDYRSDVSLLQFAYQCPTIIINCHFLFRLSLSREQLDNPHKKTTWNIYNSEFKVDIFF 1672
+ EK + A F C FL+E+ +R+ G++ +F W N+VD +V+ V+ +++++ +++ ++ L L K +K +R + S+NKRR+Q G+DLDL YVT+RVIAMSFPS G +LYRN I +VA+F + K+ +YK+YNLC E+ YD F+ +VER+++ DHNVP + +++ F K+ REW + N+IAVHCKGGKGRTGTMIC+ L+++G+F +AE L YFG RRTDL + KFQGVETPSQNRYVGYF+ IK+ P L++ +I+IT + S+++ +++ G S+ + E + G CQ ++ +S+ +L + +L+CP LH DVK++F ++ VP+ Y+ C F+FWFHT FIE+ R + R+ LDNPHK TW ++ +F +++FF
Sbjct: 126 VQEKAFEVTALCFVCYFLLEVSIRIAAKGVRQFFNEWFNVVDLVVIIVSFIVTVIYTSVDLGLGYAKLVVAGRLIRIVTFVRLYTERKHLVKGARQMVSQNKRRYQKDGFDLDLTYVTERVIAMSFPSRGKMSLYRNPIQEVARFLDFKHKDHYKVYNLCSEKTYDDTYFHGRVERFIIDDHNVPSVTDMIRFVKNVREWFDQDKSNVIAVHCKGGKGRTGTMICIWLVEAGLFGSAEASLDYFGNRRTDLSKSSKFQGVETPSQNRYVGYFQEIKEKFGGVPPEEIPLRLRQIKITALAGIGKGNGSDLTCEVYNGRSK------VFECDFGINKNCQ--AEYKSEADVLEVTVLNCPILHGDVKLRFQCSSRGVPKGYENCPFYFWFHTSFIENN------------------------RFYVQRDYLDNPHKPKTWKVFREKFSIELFF 545
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. TrEMBL
Match: R7TQR5 (Uncharacterized protein (Fragment) OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_62994 PE=4 SV=1) HSP 1 Score: 360.918 bits (925), Expect = 2.393e-115 Identity = 191/451 (42.35%), Postives = 275/451 (60.98%), Query Frame = 2
Query: 332 LDYLAFGFSCIFLIEIILRLHGIGIKTYFCNWINLVDFLVVFVTSVISIVDITLET---STXXXXXXXXXXXXXXXXXXXXXXNYKKFIK-SSRHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDYRSDVSLLQFAYQCPTIIINCHFLFRLSLSREQLDNPHKKTTWNIYNSEFKVDIFF 1672
L+ ++ F+IEI+LR+ GIK + W +VD +++ + V ++V + T S+ A + + L I+ + L KK ++ ++R S+NKRR+Q G+DLDLCY+T+R+IAMSFPSSG +LYRN I +V F +K+ +Y+IYNLC ER+YD +F++ VER + DHNVP++ E+L++AK++R+WL ++NIIAVHCKGGKGRTGTMICV L++SG FD A+ L+YFG RRTDL G+KFQGVETPSQ+RYVGYFE KK + ++P LK++ I + ++S ++ I E I E N G S C+V D ++ +T+ D P L D+K+ F + + KVP+ YD CAF+FWFHT FIE+ L L RE+LDNPHK+ TWN++ F V + F
Sbjct: 43 LEIISLFIMTYFMIEIVLRVFAFGIKHFVSKWYEVVDAVIIVASFVFAVVLTAINTHGNSSLAFARLVVAGRLLRIILLVRLIGEKKHLQQATRLAVSQNKRRYQKDGFDLDLCYITNRLIAMSFPSSGAHSLYRNPIKEVVNFMKTKHENHYRIYNLCSERSYDESLFDNNVERIRIDDHNVPKVAEMLDYAKNARQWLEADEENIIAVHCKGGKGRTGTMICVWLVESGAFDEAKESLEYFGDRRTDLSVGRKFQGVETPSQSRYVGYFEKAKKQFNGELPPSVTLKLKTITVQNLSGVAKGDGRDLSCKV-------ITESKIWEYNFGSQSDCRVACDSDTVS--VTVTPDDMPVLCGDIKVMFHSSSPKVPKNYDDCAFYFWFHTSFIENN------------------------GLWLPREELDNPHKEKTWNVFKEGFGVMLQF 460
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Cavefish
Match: ENSAMXT00000007968.2 (phosphatase and tensin homolog [Source:NCBI gene;Acc:103025186]) HSP 1 Score: 179.489 bits (454), Expect = 3.317e-50 Identity = 119/369 (32.25%), Postives = 189/369 (51.22%), Query Frame = 2
Query: 605 VTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQGYSED---IRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCP---TLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDYR-------SDVSLLQFAYQCPTIIINCHFLFRLSLSREQLDNPHKKTTWNIYNSEFKVDIFF 1672
+ S NKRR+Q G+DLDL Y+ +IAM FP+ +YRN+I DV +F +SK+ +YKIYNLC ER YDT FN +V +Y +DHN P+LE I F + +WL + D ++ A+HCK GKGRTG MIC +L+ G F A+ L ++G+ RT + +GV PSQ RYV Y+ + K+ K++ + K E ++ +F G + + + ++ ++++ +P + +K M + P + D+K++FF + K+ +K DK F FW +T FI D+ Q N L+L++ LD +K +++ FKV ++F
Sbjct: 8 MVSRNKRRYQEDGFDLDLTYIYPNLIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIRPFCEDLDKWLGEHDNHVAAIHCKAGKGRTGVMICAYLLHQGKFKKAQEALDFYGEVRT-----RDKKGVTIPSQRRYVYYYSYLLKN--------------KLDYKPVALLFHKMMFE-TVPMFSGGNCNPHFVVYQLKVKIHTSNPGNTRREDNK--------CMHFEFPQPLPVCGDIKVEFFNRQNKMLKK-DK-MFHFWVNTFFIPGPEKLEKVENGDLPKELDEIQSLEKGENDKDYLILTLTKHDLDKANKDKANRLFSPNFKVKLYF 346
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Cavefish
Match: ENSAMXT00000043891.1 (phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [Source:NCBI gene;Acc:103046962]) HSP 1 Score: 177.563 bits (449), Expect = 4.053e-49 Identity = 108/303 (35.64%), Postives = 168/303 (55.45%), Query Frame = 2
Query: 599 RHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQGYS---EDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFI 1498
+ + S NKRR+Q G+DLDL Y+ +IAM FP+ +YRN+I DV +F +SK+ +YKIYNLC ER YD FN +V +Y +DHN P+LE I F + +WL++ + ++ A+HCK GKGRTG MIC +L+ F A+ L ++G+ RT + +GV PSQ RYV Y+ + K+ ++E + K E +L +F G + + + ++ ++++ +PS + +E K H+ P D+K++FF K K+ +K DK F FW +T FI
Sbjct: 6 KEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHRNHYKIYNLCAERHYDAAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDENHVAAIHCKAGKGRTGVMICAYLLHRQKFMEAQEALDFYGEVRT-----RDKKGVTIPSQRRYVYYYSHLLKN--------------QLEYKPVALLFHKMVFE-TLPMFSGGTCNPQFVVYQLKVKIHTSNPSHTR----REDK-HMFFEFPQPLPVC-GDIKVEFFHKQNKMMKK-DKM-FHFWVNTFFI 280
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Cavefish
Match: ENSAMXT00000055423.1 (phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [Source:NCBI gene;Acc:103046962]) HSP 1 Score: 176.022 bits (445), Expect = 2.268e-48 Identity = 112/311 (36.01%), Postives = 171/311 (54.98%), Query Frame = 2
Query: 599 RHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIE----ITGA--QKFYCKSESEISLQIFQ--GYSED---IRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFI 1498
+ + S NKRR+Q G+DLDL Y+ +IAM FP+ +YRN+I DV +F +SK+ +YKIYNLC ER YD FN +V +Y +DHN P+LE I F + +WL++ + ++ A+HCK GKGRTG MIC +L+ F A+ L ++G+ RT + +GV PSQ RYV Y+ + K+ P L E +G + K+ SE + Q F+ + D + ++ ++++ +PS + +E K H+ P D+K++FF K K+ +K DK F FW +T FI
Sbjct: 6 KEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHRNHYKIYNLCAERHYDAAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDENHVAAIHCKAGKGRTGVMICAYLLHRQKFMEAQEALDFYGEVRT-----RDKKGVTIPSQRRYVYYYSHLLKNQLEYKPVALLFHKMVFETLPMFSGGTCRDSTVKNRSEANPQGFKKGNWHWDPQFVVYQLKVKIHTSNPSHTR----REDK-HMFFEFPQPLPVC-GDIKVEFFHKQNKMMKK-DKM-FHFWVNTFFI 303
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Cavefish
Match: ENSAMXT00000038725.1 (phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [Source:NCBI gene;Acc:103046962]) HSP 1 Score: 112.079 bits (279), Expect = 1.723e-26 Identity = 99/371 (26.68%), Postives = 164/371 (44.20%), Query Frame = 2
Query: 599 RHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQGYS---EDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDYRSDVSLLQFAYQCPTIIINCH----------FLFRLSLSREQLDNPHKKTTWNIYNSEFKVDIFF 1672
+ + S NKRR+Q G+DLDL Y+ +IAM T A +T+++ E Y +DHN P+LE I F + +WL++ + ++ A+HCK GKGRTG MIC +L+ F A+ L ++G+ RT + +GV PSQ RYV Y+ + K+ ++E + K E +L +F G + + + ++ ++++ +PS + +E K H+ P D+K++FF K K+ +K DK F FW +T FI + I N +L L+L++ LD +K ++ FKV ++F
Sbjct: 6 KEIVSRNKRRYQEDGFDLDLTYIYPNIIAMVHLQHVHTP------------------------------AQNTRVYQ---EEYPFEDHNPPQLELIKPFCEDLDQWLSEDENHVAAIHCKAGKGRTGVMICAYLLHRQKFMEAQEALDFYGEVRT-----RDKKGVTIPSQRRYVYYYSHLLKN--------------QLEYKPVALLFHKMVFE-TLPMFSGGTCNPQFVVYQLKVKIHTSNPSHTR----REDK-HMFFEFPQPLPVC-GDIKVEFFHKQNKMMKK-DKM-FHFWVNTFFIPGPEESPEKWENGSVVNDIDSNSSQTGAPDADRDYLI-LTLTKNDLDKANKDKANRYFSPNFKVKLYF 314
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Cavefish
Match: ENSAMXT00000055284.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02001063.1:312263:351370:1 gene:ENSAMXG00000032162.1 transcript:ENSAMXT00000055284.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 113.235 bits (282), Expect = 2.931e-26 Identity = 84/291 (28.87%), Postives = 136/291 (46.74%), Query Frame = 2
Query: 641 GYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMIC--VHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDY 1507
GY+LDL YVT+R+IA+SFP S Y +++ DV + SK+ NY + NL E+R +D N + D + P L++I K+ WL +++ +HC+GGKGR G +IC VH D + +A+ L F R+ K + TPSQ RYV ++ S K+ N L + I + G F ++++Q + + + ++ G H + I++ L D+ +K F +K P + + F FHTG ++DY
Sbjct: 4 GYELDLTYVTERIIAVSFPQSCSEETYLHNLKDVTRMLKSKHADNYLVINLSEKR-HDLTRMNPKTLDTGWPDLHAPPLDKICTICKAMENWLNADPLHVVVIHCRGGKGRIGVVICSFVHFTD--ISASADQALDRFAMRK---FYDDKVSALMTPSQKRYVWILNSL-LSGSMKM-NASPLFLHCIILHGIPNFDNSGVCRPFIKVYQAM-QAVYYSGVYQIGPG-------------HRHKVCIVLEPAQLLKGDIMVKCF--HKSSPSQRE-IIFRLQFHTGAVQDY 269
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Sea Lamprey
Match: TNS1 (tensin 1 [Source:HGNC Symbol;Acc:HGNC:11973]) HSP 1 Score: 96.6709 bits (239), Expect = 4.672e-21 Identity = 52/169 (30.77%), Postives = 89/169 (52.66%), Query Frame = 2
Query: 638 GGYDLDLCYVTDRVIAMSFPSSGFTAL-YRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETI 1141
GG DL+L Y+T+R+I++ P+ G + + Y + DVA+ +SK+ Y + NL E R +D + FN V + D + P L+ + K+ WL +++ +HCKG K RTG ++ ++ +G+ +A L + ++ K + PSQ RYV YF +
Sbjct: 9 GGRDLELTYITERIISLCAPTGGDSHVAYHQQMRDVARMLHSKHANGYLVINLSERR-HDIEKFNVHVRDFGWPDLHAPPLDVLCSICKAMDSWLNADPAHVVVIHCKGNKCRTGVVVASYMYYNGICASASQALDRYAMKK---FYDDKVAKLSQPSQRRYVSYFSEL 173
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005736.1 (pep scaffold:Pmarinus_7.0:GL478791:38400:53446:1 gene:ENSPMAG00000005201.1 transcript:ENSPMAT00000005736.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 90.5077 bits (223), Expect = 5.350e-20 Identity = 60/209 (28.71%), Postives = 94/209 (44.98%), Query Frame = 2
Query: 641 GYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQG 1267
G +LDL Y+T+R+IA+S+P G Y I NL E R +D + N QV+ + D + P L+ + K+ WL Q+++ +HCKG KGRTG ++ ++ + + +A L + ++ K V PSQ RYV YF + S K+ N L + I + G F L+I+Q
Sbjct: 10 GQELDLTYITERIIAVSYPPGGSQLTY--------------------ILNLSERR-HDIEKLNPQVKDFGWPDLHAPPLDILCSLCKAMDSWLNADPQHVVVIHCKGNKGRTGVVVASYMYYNSICASAHQALDRYAMKK---FYDDKVAAVSQPSQKRYVTYFSEL-LSGKTKVNNMPLF-LHHIVVQGLPNFEANGGCRPFLKIYQA 192
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007420.1 (pep scaffold:Pmarinus_7.0:GL480034:173278:177354:1 gene:ENSPMAG00000006694.1 transcript:ENSPMAT00000007420.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 85.8853 bits (211), Expect = 8.277e-20 Identity = 52/142 (36.62%), Postives = 83/142 (58.45%), Query Frame = 2
Query: 323 EKELDYLAFGFSCIFLIEIILRLHGIGIKTYFCNWINLVDFLVVFVTSVISIVDITLETSTXXXX-----XXXXXXXXXXXXXXXXXXNYKKFIKSSRHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSI 733
+ L + S FL+++ LR+ G ++YF +N+ D +V +T V+SIV +++ S A ++ + L + + L+ K+SR + S+NKRR++ G+DLDL YVT+RVIAMSFPSSG ++YRN I
Sbjct: 30 SRALSASSLAISVFFLVDVALRVFVSGFRSYFREKLNIADAGIVVITLVVSIVYTSIDLSGTALLPRYNKVLRVLRLIMIIRVWRLVSQRHHLEKASRQMVSQNKRRYRKDGFDLDLTYVTERVIAMSFPSSGTQSMYRNPI 171
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009584.1 (pep scaffold:Pmarinus_7.0:GL480473:6650:34123:1 gene:ENSPMAG00000008668.1 transcript:ENSPMAT00000009584.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 90.5077 bits (223), Expect = 3.657e-19 Identity = 45/138 (32.61%), Postives = 71/138 (51.45%), Query Frame = 2
Query: 647 DLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRR 1060
DLD+ Y+T RV MS+P+ G + ++N I DV + +S++ +Y ++NLC +R Y F+++V Y P L + F K WL + +NI VHC G+ + +C L +F AE L + RR
Sbjct: 6 DLDISYITTRVAVMSYPAEGVESAFKNHIEDVRAYLDSRHPDHYAVFNLC-QRGYRPARFHNRVSEYAFPTRRAPNLGCLYTFCKDLLVWLKQDPKNICVVHCLDGRAVSAVAVCSFLCFCRLFSTAEAALYMYSLRR 142
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010485.1 (pep scaffold:Pmarinus_7.0:GL477590:24098:49109:-1 gene:ENSPMAG00000009496.1 transcript:ENSPMAT00000010485.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 87.0409 bits (214), Expect = 7.788e-19 Identity = 57/212 (26.89%), Postives = 99/212 (46.70%), Query Frame = 2
Query: 644 YDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGA----QKFYCKSESEISLQIFQG 1267
++ DL Y+T+R+IA + P +++S+ D+A SK+ Y I NL R ++ N QV + + P L+ + K+ WL ++ +HC G G G +I + S + +A+ L F +R + +KF + PSQ RYV YF + S K+ N + + I + GA + +S + L+++QG
Sbjct: 5 FEFDLTYITERIIATTLPPGIAEHAHQSSLRDIAGMLTSKHADKYLIINLSGRRNEMLQL-NPQVLDFGWPSRHAPHLDTLCSICKAIDSWLNSHPLHVAVLHCAGNSGSAGVVIAAFMHYSAICASADQALDRFAMKRFYV---EKFASLTQPSQQRYVYYFNGL-LSGSIKM-NSAPVYLSHILLHGAWGPPPRLDTRSVKRVFLRVYQG 210
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Nematostella
Match: EDO47071 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RN45]) HSP 1 Score: 330.102 bits (845), Expect = 9.643e-109 Identity = 166/361 (45.98%), Postives = 224/361 (62.05%), Query Frame = 2
Query: 590 KSSRHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDYRSDVSLLQFAYQCPTIIINCHFLFRLSLSREQLDNPHKKTTWNIYNSEFKVDIFF 1672
+++R + S+NKRR+Q G+DLDL YVT+RVIAMSFPSSG +YRN I++VA+F ++K+ +YK+YNLC ER+YD IF++QVER ++ DHNVPRL ++L F + REWL K N+IAVHCKGGKGRTGT IC LI SG F+ A+ L+YFG RRTD GK +QGV+TPSQ RYVGY E I + ++P LK++ I+I G ++ L++ I ++ M+ + Q D + + ++ + DCP+L D+KIKF++ N VP YD CAF+FWFHT FIE+Y RL L RE+LDNPHK W +Y F VDI F
Sbjct: 26 RATRRMISQNKRRYQQDGFDLDLTYVTERVIAMSFPSSGKHKMYRNPISEVARFLDTKHSDHYKVYNLCSERSYDPSIFHNQVERILIDDHNVPRLSQLLYFCHNVREWLDKDPSNVIAVHCKGGKGRTGTAICAWLIASGQFEQAQHSLEYFGVRRTDYSVGKTYQGVQTPSQGRYVGYLEQIFTKLNRRMPPAVTLKLKTIKIDGIGGVGNGDGKDLRLEVI------INSSVVCHMSCSEGQPGQYFEDLD--KLVIAVGETDCPSLTGDIKIKFYSNNPNVPVGYDHCAFYFWFHTSFIENY------------------------RLFLRREELDNPHKPKVWKVYKETFAVDITF 354
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Nematostella
Match: EDO32901 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7STQ6]) HSP 1 Score: 173.326 bits (438), Expect = 4.310e-49 Identity = 119/364 (32.69%), Postives = 176/364 (48.35%), Query Frame = 2
Query: 599 RHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLK-IEKIEITGAQKFYCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDYRSDVSLLQFAYQCPTIII-----NCHFLFRLSLSREQLDNPHKKTTWNIYNSEFKVDIFF 1672
+ + S+ KRRFQ G+DLDL Y+ ++AM FPS +YRN + +V +F K+ +YK+YNLC ER YD F+++V Y DHN P E I F EWL S+ N+ +HCK GKGRTG MIC +L+ +G F + + ++Y+G RT + +GV PSQ RYV Y+ + ++ +P LL+ E I I Q C I Y I +IE SK TS K L I D+K++FF K+ ++ F FWF+T FI + ++ PTI N + ++ ++ +D HK +++ +FKV F
Sbjct: 5 KQLVSKKKRRFQEDGFDLDLTYIKPNIVAMGFPSEKLEGVYRNHMDEVYRFLEQKHKDSYKVYNLCSERQYDPMRFHNRVATYPFDDHNAPPFELIKPFCDDVDEWLKASNLNVAIIHCKAGKGRTGVMICAYLLHNGHFKDTKEAMEYYGNART-----RNAKGVTIPSQRRYVEYYGYLLRNCLTYVPTMVLLRGFEIITIPNMQGGNC-----CPFYIIWQYKVKIHTSKLIES-----SKKGDTSIKLELSQPLPIC--------GDIKVEFFHKDTFGRKER---MFQFWFNTFFIS---TGANMTDSREGEPTIHTFKESRNSDVRW-FAIPKQFVDKAHKDNKCKVFSPDFKVSNVF 338
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Nematostella
Match: EDO45782 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRM0]) HSP 1 Score: 142.124 bits (357), Expect = 7.216e-38 Identity = 102/304 (33.55%), Postives = 143/304 (47.04%), Query Frame = 2
Query: 599 RHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKN--KKVPEKYDKCAFFFWFHTGFIED 1504
RHV E +DLDL Y+T+R+IAMSFP +G + YRN++ DVAK K+ Y ++NL E R YD N QV + DH P LE + KS WL Q+++ VHCKGGKGRTG +I ++ S + + E L +F +R K GV PSQ RYV YF + K+ + + + + + G F K + L+++ G + + VT D E + I I LH DV IK + KN V + +C FHTG I+D
Sbjct: 9 RHVDHE---------FDLDLTYITERIIAMSFPGTGLESTYRNNLRDVAKMLQRKHQDKYMVFNLSERR-YDISKLNHQVLDFGWPDHLAPPLERLCSIIKSIDSWLKTDPQHVVVVHCKGGKGRTGVVISAYMHFSKMCSSPEAALDWFAIKR---FYDDKLGGVTQPSQRRYVHYFSDYLEG-KIKLSSEPMF-LHHVIVHGIPNFDSKGGCKPFLRVYDGLKLVYTSGVFL-----------VTQDMER----VCITIEGGLILHGDVLIKCYHKNTLSSVRDIIFRCQ----FHTGAIKD 278
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Nematostella
Match: EDO43926 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RX98]) HSP 1 Score: 99.3673 bits (246), Expect = 7.981e-22 Identity = 84/307 (27.36%), Postives = 133/307 (43.32%), Query Frame = 2
Query: 617 NKRRFQS-GGY---DLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKF-YCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCP---TLHDDVKIKFF----TKNKKVPEKYDKC-AFFFWFHTGFI 1498
+ + FQS GY DLDL Y+T R+I MSFP+ G + Y+N+I DV +F +K+ Y + N+ R Y + +V + +P LE I+ + WL K +I +HC G+ +G ++ + +F N F RR + Q TPSQ RY+ Y + +P K P L I+ + + F ++ ++++QG +R++ V ++ +E L+ + P TL DV I + T KV K F FHTGFI
Sbjct: 390 SNKAFQSMAGYVKNDLDLSYITSRIIVMSFPAEGIESTYKNNIDDVREFLEAKHYEQYFVVNV-SPRNYRADKLSTRVLHQCWPVNRLPPLESIISLCRKIFVWLKKDSSRVIVIHCMDGRVASGVLVSAFFVFCKLFKNPNGAADMFSIRRCGIGQKVAL----TPSQERYLLYIAELINNPSMK-PQKNSLYIKSVTLNPVPAFNKARNGCRPFIEMYQG-----NQRVL----------TTVQEIEKMREFTLSDGKVTFPVNLTLQGDVTIIVYHGRSTLGGKVQGKMASMRVFLLQFHTGFI 675
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Nematostella
Match: EDO29614 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T353]) HSP 1 Score: 58.151 bits (139), Expect = 4.327e-11 Identity = 26/66 (39.39%), Postives = 35/66 (53.03%), Query Frame = 2
Query: 770 PNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGK 967
P+ ++ C ER YD F+++V Y DHN P E I F EWL S+ N+ +HCK GK
Sbjct: 4 PSRSLHFSCSERQYDPMRFHNRVATYPFDDHNAPPFELIKPFCDDVDEWLKASNLNVAIIHCKAGK 69
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Medaka
Match: tpte (phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 [Source:NCBI gene;Acc:101172265]) HSP 1 Score: 313.538 bits (802), Expect = 5.295e-100 Identity = 176/459 (38.34%), Postives = 267/459 (58.17%), Query Frame = 2
Query: 326 KELDYLAFGFSCIFLIEIILRLHGIGIKTYFCNWINLVD---------FLVVFVTSVISIVDITLETSTXXXXXXXXXXXXXXXXXXXXXXNYKKFIKSSRHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDYRSDVSLLQFAYQCPTIIINCHFLFRLSLSREQLDNPHKKTTWNIYNSEFKVDIFFI 1675
K L+ ++ S FL +++LR++ G K YF + +N+VD +V+ S +S V + RF+ I L+R+ R+ K+ K +R + SENKRR+Q G+DLDL YVTDRVIAMSFPSSG A YRN I +VA+F ++K+ +YK++NLC E+ YD + F+ +VER + DHNVP LE++L+F S REW++ QN+IA+HCKGGKGRTGTM+C LIDS F++A+ L+YFG+RRTD + KFQGVETPSQ+RYVGY+E +K + ++P + L+I+ + I S++ ++I +R ++ + C V D S ++++ + P + DVK+ F + +P+ Y+ F+FWF+T F+E +L RE+LDNPHK TWN+Y +F + ++F+
Sbjct: 68 KALEAVSLSISFFFLADVLLRVYVEGFKVYFRSKLNIVDACVVVLTLVVTMVYTFSDLSGVSLIPRVVNFFRFLRIIILVRVFRLAAQK----KELEKVTRRMISENKRRYQKDGFDLDLTYVTDRVIAMSFPSSGKQAFYRNPIKEVARFLDTKHEGHYKVFNLCSEKGYDPQHFHYRVERVFIDDHNVPALEDMLKFTASVREWMSADPQNVIAIHCKGGKGRTGTMVCTWLIDSDQFESAQDSLEYFGERRTDKTRSSKFQGVETPSQSRYVGYYEVMKNKFNRQLPPPQSLRIKSLRIHSIAGVGRGDGSDLKVKII------VRGELVFQCVCAQQENCTVFPDAGSNAAVISLQ--NGPVVEGDVKV-MFESSAGLPKGYEDVPFYFWFNTSFVEHN------------------------KLFFPREELDNPHKPKTWNLYKEDFGITVYFL 489
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Medaka
Match: tpte (phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 [Source:NCBI gene;Acc:101172265]) HSP 1 Score: 313.538 bits (802), Expect = 8.605e-100 Identity = 176/459 (38.34%), Postives = 267/459 (58.17%), Query Frame = 2
Query: 326 KELDYLAFGFSCIFLIEIILRLHGIGIKTYFCNWINLVD---------FLVVFVTSVISIVDITLETSTXXXXXXXXXXXXXXXXXXXXXXNYKKFIKSSRHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDYRSDVSLLQFAYQCPTIIINCHFLFRLSLSREQLDNPHKKTTWNIYNSEFKVDIFFI 1675
K L+ ++ S FL +++LR++ G K YF + +N+VD +V+ S +S V + RF+ I L+R+ R+ K+ K +R + SENKRR+Q G+DLDL YVTDRVIAMSFPSSG A YRN I +VA+F ++K+ +YK++NLC E+ YD + F+ +VER + DHNVP LE++L+F S REW++ QN+IA+HCKGGKGRTGTM+C LIDS F++A+ L+YFG+RRTD + KFQGVETPSQ+RYVGY+E +K + ++P + L+I+ + I S++ ++I +R ++ + C V D S ++++ + P + DVK+ F + +P+ Y+ F+FWF+T F+E +L RE+LDNPHK TWN+Y +F + ++F+
Sbjct: 87 KALEAVSLSISFFFLADVLLRVYVEGFKVYFRSKLNIVDACVVVLTLVVTMVYTFSDLSGVSLIPRVVNFFRFLRIIILVRVFRLAAQK----KELEKVTRRMISENKRRYQKDGFDLDLTYVTDRVIAMSFPSSGKQAFYRNPIKEVARFLDTKHEGHYKVFNLCSEKGYDPQHFHYRVERVFIDDHNVPALEDMLKFTASVREWMSADPQNVIAIHCKGGKGRTGTMVCTWLIDSDQFESAQDSLEYFGERRTDKTRSSKFQGVETPSQSRYVGYYEVMKNKFNRQLPPPQSLRIKSLRIHSIAGVGRGDGSDLKVKII------VRGELVFQCVCAQQENCTVFPDAGSNAAVISLQ--NGPVVEGDVKV-MFESSAGLPKGYEDVPFYFWFNTSFVEHN------------------------KLFFPREELDNPHKPKTWNLYKEDFGITVYFL 508
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Medaka
Match: tpte (phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 [Source:NCBI gene;Acc:101172265]) HSP 1 Score: 308.916 bits (790), Expect = 1.665e-98 Identity = 152/366 (41.53%), Postives = 224/366 (61.20%), Query Frame = 2
Query: 578 KKFIKSSRHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDYRSDVSLLQFAYQCPTIIINCHFLFRLSLSREQLDNPHKKTTWNIYNSEFKVDIFFI 1675
K+ K +R + SENKRR+Q G+DLDL YVTDRVIAMSFPSSG A YRN I +VA+F ++K+ +YK++NLC E+ YD + F+ +VER + DHNVP LE++L+F S REW++ QN+IA+HCKGGKGRTGTM+C LIDS F++A+ L+YFG+RRTD + KFQGVETPSQ+RYVGY+E +K + ++P + L+I+ + I S++ ++I +R ++ + C V D S ++++ + P + DVK+ F + +P+ Y+ F+FWF+T F+E +L RE+LDNPHK TWN+Y +F + ++F+
Sbjct: 136 KELEKVTRRMISENKRRYQKDGFDLDLTYVTDRVIAMSFPSSGKQAFYRNPIKEVARFLDTKHEGHYKVFNLCSEKGYDPQHFHYRVERVFIDDHNVPALEDMLKFTASVREWMSADPQNVIAIHCKGGKGRTGTMVCTWLIDSDQFESAQDSLEYFGERRTDKTRSSKFQGVETPSQSRYVGYYEVMKNKFNRQLPPPQSLRIKSLRIHSIAGVGRGDGSDLKVKII------VRGELVFQCVCAQQENCTVFPDAGSNAAVISLQ--NGPVVEGDVKV-MFESSAGLPKGYEDVPFYFWFNTSFVEHN------------------------KLFFPREELDNPHKPKTWNLYKEDFGITVYFL 468
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Medaka
Match: PTEN (phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [Source:NCBI gene;Acc:101173689]) HSP 1 Score: 196.438 bits (498), Expect = 2.534e-56 Identity = 130/372 (34.95%), Postives = 196/372 (52.69%), Query Frame = 2
Query: 599 RHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIE-----DYR---------SDVSLLQFAYQCPTIIINCHFLFRLSLSREQLDNPHKKTTWNIYNSEFKVDIFF 1672
+ + S NKRRFQ G+DLDL Y+ +IAM FP+ +YRN+I DV +F +SK+ +YKIYNLC ER YDT FN +V +Y +DHN P+LE I F + +WL++++ ++ A+HCK GKGRTG MIC +L+ G F A+ L ++G+ RT + +GV PSQ RYV Y+ + K+ P L E SES S + + + ++ ++++ +P+ + +E K LL + D+K++FF K KV +K + F FW +T FI Y+ SDVS YQ P + FL L+L++ +LD +K ++ FKV +FF
Sbjct: 7 KEIVSRNKRRFQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTTKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSENEHHVAAIHCKAGKGRTGVMICAYLLHRGKFREAQEALDFYGEVRT-----RDKKGVTIPSQRRYVVYYNYLLKNRLQYKPVALLFHKMMFETVPMFTVGTCSESG-SGPPLHAHPQFVVYQLKVKIHTSNPAHTR----REDK--LLLFEFPQPLPVCGDIKVEFFHKQNKVMKK--EKMFHFWINTFFIPGPEEASYKLENGSAAPNSDVS--DRTYQNPGDANDKDFLV-LTLTKNELDKANKDKANKNFSPNFKVRLFF 361
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Medaka
Match: ENSORLT00000007833.2 (phosphatase and tensin homolog [Source:NCBI gene;Acc:101171856]) HSP 1 Score: 180.259 bits (456), Expect = 3.200e-50 Identity = 111/305 (36.39%), Postives = 168/305 (55.08%), Query Frame = 2
Query: 599 RHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIE----ITGAQKFYCKSESEISLQIFQGYSEDIRERMII-EMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFI 1498
+ + S NKRR+Q G+DLDL Y+ +IAM FP+ +YRN+I DV +F +SK+ +YKIYNLC ER YD FN +V +Y +DHN P+LE I F + +WL++ D ++ A+HCK GKGRTG MIC +L+ G F A+ L ++G+ RT + +GV PSQ RYV Y+ + K+ P L E +G K+ SE + Q F+ + + ++ ++ + + + + +E K H+ P D+K++FF K K+ +K DK F FW +T FI
Sbjct: 6 KEMVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDAAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLEAQEALDFYGEVRT-----RDKKGVTIPSQRRYVCYYSYLLKNQLEYKPVALLFHKMVFETLPMFSGGTCRDVKNRSEPTPQGFKKGNWHWDPQFVVYQLKVKIHTSNPLHTRREDK-HMYFEFPQPLPVC-GDIKVEFFHKQNKMMKK-DK-MFHFWVNTFFI 301
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Planmine SMEST
Match: SMESG000060206.1 (SMESG000060206.1) HSP 1 Score: 892.108 bits (2304), Expect = 0.000e+0 Identity = 488/518 (94.21%), Postives = 489/518 (94.40%), Query Frame = 2
Query: 140 MENKQIYHVTFDEVDKGLNRDCVDKSKAAARQLTDNXXXXXXXXXXXXXXXXXXXTSFILDEKELDYLAFGFSCIFLIEIILRLHGIGIKTYFCNWINLVDFLVVFVTSVISIVDITLETSTXXXXXXXXXXXXXXXXXXXXXXNYKKFIKSSRHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKFYCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLLTIMILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDYRSDVSLLQFAYQCPTIIINCHFLFRLSLSREQLDNPHKKTTWNIYNSEFKVDIFFINDSLVD 1693
MENKQIYHVTFDEVDKGLNRDCVDKSKAAARQLTDNIAFRIIIIFLILADIGILI SFILD+KELDYLAFGFSCIFLIEIILRLHGIGIKTYFCNWINLVDFLVVFVTSVISIVDITLETSTRARFIIAIRLLRLPRIIGLLLRNYKKFIKSSRHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYG NYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQK YCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLL I ILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDY RLSLSREQLDNPHKKTTWNIYNSEFKVDIFFINDSLVD
Sbjct: 1 MENKQIYHVTFDEVDKGLNRDCVDKSKAAARQLTDNIAFRIIIIFLILADIGILIASFILDKKELDYLAFGFSCIFLIEIILRLHGIGIKTYFCNWINLVDFLVVFVTSVISIVDITLETSTRARFIIAIRLLRLPRIIGLLLRNYKKFIKSSRHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGSNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKSPDFKIPNGKLLKIEKIEITGAQKLYCKSESEISLQIFQGYSEDIRERMIIEMNLGDPSKCQVTSDKESKEHLLKIKILDCPTLHDDVKIKFFTKNKKVPEKYDKCAFFFWFHTGFIEDY------------------------RLSLSREQLDNPHKKTTWNIYNSEFKVDIFFINDSLVD 494
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Planmine SMEST
Match: SMESG000072902.1 (SMESG000072902.1) HSP 1 Score: 154.066 bits (388), Expect = 4.514e-41 Identity = 77/184 (41.85%), Postives = 111/184 (60.33%), Query Frame = 2
Query: 599 RHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFETIKKS 1150
R + S+ KRR++ G++LDL YVT R+IAM FP+ F ALYRN I DV+KFF + YKIYNLC ER ++ F+ ++ R+ DHN P +++ ++L N++A++CK GKGRTG ++C LI +A LQ +G+ RT L GK GV PSQ RY+ Y++ K+
Sbjct: 6 RTIVSKKKRRYKKQGFNLDLSYVTSRIIAMGFPAEKFEALYRNDIDDVSKFFEVNHCGKYKIYNLCRERNFNASKFSGEIARFPFDDHNAPIFTDLVACVNDIAQFLDSCPDNVVAINCKAGKGRTGVIVCCTLIHCENNKDATTALQDYGKSRT--LNGK---GVTIPSQIRYIFYYDHFVKN 184
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Planmine SMEST
Match: SMESG000043909.1 (SMESG000043909.1) HSP 1 Score: 147.517 bits (371), Expect = 3.171e-38 Identity = 75/181 (41.44%), Postives = 108/181 (59.67%), Query Frame = 2
Query: 599 RHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIF--NDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFE 1135
+ + S+ K R+ G+DLDL Y+T R+IAM FP+ + +YRN I DV FF+ K+ +Y+IYNLC ER D + F N +Y DHN P +++E K +++L NI+A+ CK GKGRTG ++C L+ +A LQ++G+RRT GK GV PSQ R++ YFE
Sbjct: 6 KELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRT--TNGK---GVTIPSQIRFIYYFE 181
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Planmine SMEST
Match: SMESG000081891.1 (SMESG000081891.1) HSP 1 Score: 66.2402 bits (160), Expect = 4.875e-11 Identity = 59/215 (27.44%), Postives = 93/215 (43.26%), Query Frame = 2
Query: 647 DLDLCYVTDRVIAMSFPS-SGFTALYRNSITDVAKFFNSKYGPNYKIYNLCEERAYDTKIFNDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYF-----ETIKKSPDFKIPNGKLLKIEKIEITGAQKF-YCKSESEISLQIFQGY 1270
DL++ YVT R+I M P SG AL R+ I DV F + ++ Y IYNL R+ T+ FND+V + ++ WL +N+I + C G+ +G + L + D + + RR D +F T SQ RY+ Y +S +IP+ ++K+ IE+ F K+ ++IF Y
Sbjct: 459 DLNITYVTSRIIMMPTPGESGIDALTRDKIEDVQTFLDFRHPNQYYIYNLSL-RSIKTERFNDRVMQLGFDSMKPMSFNNLVSVCIHQLSWLLADAKNVIVIQCTDGRIGSGLNVAALLCFCRLVDTSSAAVNIVKFRRGDC----QF----TSSQLRYIDYICRLMHNISNQSIGPEIPHKFIVKLTGIELEPVPIFNRAKTGVRPYVEIFNDY 664 The following BLAST results are available for this feature:
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 1
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 4
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30033121 ID=SMED30033121|Name=Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2|organism=Schmidtea mediterranea sexual|type=transcript|length=1782bpback to top protein sequence of SMED30033121-orf-1 >SMED30033121-orf-1 ID=SMED30033121-orf-1|Name=SMED30033121-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=519bp MENKQIYHVTFDEVDKGLNRDCVDKSKAAARQLTDNIAFRIIIIFLILADback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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