Dvl-2

Overview
NameDvl-2 (ADZ58512.1)
Smed IDSMED30033103
Length (bp)3159
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Dvl-2 (SMED30033103) t-SNE clustered cells

Violin plots show distribution of expression levels for Dvl-2 (SMED30033103) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Dvl-2 (SMED30033103) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Dvl-2 (SMED30033103) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30033103

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 11

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
pharynxSMED30033103SMESG000010246.1 EU130788.1smed_ncbi_20200123PMID:21282632
Almuedo-Castillo et al., 2011
whole organism asexual adult colorimetric in situ hybridization evidence
cephalic gangliaSMED30033103SMESG000010246.1 EU130788.1smed_ncbi_20200123PMID:21282632
Almuedo-Castillo et al., 2011
whole organism asexual adult colorimetric in situ hybridization evidence
ventral nerve cordSMED30033103SMESG000010246.1 EU130788.1smed_ncbi_20200123PMID:21282632
Almuedo-Castillo et al., 2011
whole organism asexual adult colorimetric in situ hybridization evidence
whole organismSMED30033103SMESG000010246.1 EU130788.1smed_ncbi_20200123PMID:21282632
Almuedo-Castillo et al., 2011
whole organism asexual adult colorimetric in situ hybridization evidence
parenchymal cellSMED30033103SMESG000010246.1 EU130788.1smed_ncbi_20200123PMID:21282632
Almuedo-Castillo et al., 2011
whole organism asexual adult colorimetric in situ hybridization evidence
head regionSMED30033103SMESG000060422.1 OX_Smed_1.0.13377ox_Smed_v2PMID:24238224
Kao et al., 2013
whole organism asexual adult RNA-sequencing evidence
pharynxSMED30033103SMESG000010246.1 EU130788.1smed_ncbi_20200123PMID:18063757
Gurley et al., 2008
whole organism asexual adult colorimetric in situ hybridization evidence
cephalic gangliaSMED30033103SMESG000010246.1 EU130788.1smed_ncbi_20200123PMID:18063757
Gurley et al., 2008
whole organism asexual adult colorimetric in situ hybridization evidence
esophagusSMED30033103SMESG000010246.1 EU130788.1smed_ncbi_20200123PMID:18063757
Gurley et al., 2008
whole organism asexual adult colorimetric in situ hybridization evidence
ventral nerve cordSMED30033103SMESG000010246.1 EU130788.1smed_ncbi_20200123PMID:18063757
Gurley et al., 2008
whole organism asexual adult colorimetric in situ hybridization evidence
whole organismSMED30033103SMESG000010246.1 EU130788.1smed_ncbi_20200123PMID:18063757
Gurley et al., 2008
whole organism asexual adult colorimetric in situ hybridization evidence
Note: Hover over icons to view figure legend
Homology
BLAST of Dvl-2 vs. Ensembl Human
Match: DVL3 (dishevelled segment polarity protein 3 [Source:HGNC Symbol;Acc:HGNC:3087])

HSP 1 Score: 210.69 bits (535), Expect = 1.717e-56
Identity = 96/126 (76.19%), Postives = 109/126 (86.51%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTA 1228
            LNI+TV LNM+   FLGISIVGQSN+ GDGGIY+GSIMKGGAVA DGRIEPGDM+L+VN+I+FE+MSNDDAVR LRE V KPGPI L VAKCWDP+P+G FT+PR EP+RPIDP AWV HT AMT 
Sbjct:  245 LNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNEINFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPRGCFTLPRSEPIRPIDPAAWVSHTAAMTG 370          

HSP 2 Score: 163.696 bits (413), Expect = 4.892e-41
Identity = 73/134 (54.48%), Postives = 105/134 (78.36%), Query Frame = 2
Query: 1535 ESERYQEELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRLSLDQVESVSEVGVNGPHHLAALPPP 1936
            ++ER  ++ HL+ ++D+  I++ ++ P+SGL++RDR+WLKIT+PNAFIGS++VDWLY ++EGF+DR+EARKYA+NLLK G+I+HTVNK+TFSEQCYY+ G+   NM+ LSL   +  S  G +    LA LP P
Sbjct:  397 DTERL-DDFHLSIHSDMAAIVKAMASPESGLEVRDRMWLKITIPNAFIGSDVVDWLYHNVEGFTDRREARKYASNLLKAGFIRHTVNKITFSEQCYYIFGDLCGNMANLSLHDHDGSS--GASDQDTLAPLPHP 527          

HSP 3 Score: 136.346 bits (342), Expect = 3.604e-32
Identity = 59/82 (71.95%), Postives = 70/82 (85.37%), Query Frame = 2
Query:  104 ETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALNRPHYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGS 349
            ET+IIYH+D +ETPYL+KL +  ++VTL D K  L RP YK+FFKSMDDDFGVVKEEI+DD AKLPCF GRV+SWLV+AEGS
Sbjct:    3 ETKIIYHLDGQETPYLVKLPLPAERVTLADFKGVLQRPSYKFFFKSMDDDFGVVKEEISDDNAKLPCFNGRVVSWLVSAEGS 84          
BLAST of Dvl-2 vs. Ensembl Human
Match: DVL1 (dishevelled segment polarity protein 1 [Source:HGNC Symbol;Acc:HGNC:3084])

HSP 1 Score: 204.527 bits (519), Expect = 8.646e-55
Identity = 93/127 (73.23%), Postives = 107/127 (84.25%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTAG 1231
            LNIVTV LNM+   FLGISIVGQSN  GDGGIY+GSIMKGGAVA DGRIEPGDM+L+VND++FE+MSNDDAVR LRE V + GPI+L VAKCWDP P+ YFT+PR +PVRPIDP AW+ HT A+T  
Sbjct:  247 LNIVTVTLNMERHHFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLREIVSQTGPISLTVAKCWDPTPRSYFTVPRADPVRPIDPAAWLSHTAALTGA 373          

HSP 2 Score: 156.377 bits (394), Expect = 8.029e-39
Identity = 72/132 (54.55%), Postives = 99/132 (75.00%), Query Frame = 2
Query: 1544 RYQ-EELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRLSLDQVESVSEVGVNGPHHLAALPPP 1936
            RY+ EE  LT  +D+  ++RV+  PDSGL+IRDR+WLKIT+ NA IG+++VDWLY H+EGF +R+EARKYA++LLK G+++HTVNK+TFSEQCYYV G+   N++ L+L+   S    G +    LA LP P
Sbjct:  376 RYELEEAPLTVKSDMSAVVRVMQLPDSGLEIRDRMWLKITIANAVIGADVVDWLYTHVEGFKERREARKYASSLLKHGFLRHTVNKITFSEQCYYVFGDLCSNLATLNLNSGSS----GTSDQDTLAPLPHP 503          

HSP 3 Score: 135.191 bits (339), Expect = 6.595e-32
Identity = 62/85 (72.94%), Postives = 72/85 (84.71%), Query Frame = 2
Query:  104 ETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNAL-NRP--HYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGS 349
            ET+IIYH+DEEETPYL+KL ++P++VTL D KN L NRP   YK+FFKSMD DFGVVKEEI DD AKLPCF GRV+SWLV AEG+
Sbjct:    3 ETKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDFGVVKEEIFDDNAKLPCFNGRVVSWLVLAEGA 87          
BLAST of Dvl-2 vs. Ensembl Human
Match: DVL2 (dishevelled segment polarity protein 2 [Source:HGNC Symbol;Acc:HGNC:3086])

HSP 1 Score: 205.682 bits (522), Expect = 9.254e-55
Identity = 92/126 (73.02%), Postives = 109/126 (86.51%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTA 1228
            LNI+TV LNM+   FLGISIVGQSN+ GDGGIY+GSIMKGGAVA DGRIEPGDM+L+VND++FE+MSNDDAVR LR+ V KPGPI L VAKCWDP+P+ YFT+PR EP++PIDP AWV H+ A+T 
Sbjct:  263 LNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDMNFENMSNDDAVRVLRDIVHKPGPIVLTVAKCWDPSPQAYFTLPRNEPIQPIDPAAWVSHSAALTG 388          

HSP 2 Score: 151.369 bits (381), Expect = 6.539e-37
Identity = 64/111 (57.66%), Postives = 90/111 (81.08%), Query Frame = 2
Query: 1505 SIVTTSSSLPESERYQEELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGN 1837
            S +T+ SSLP+     E   L+ +TD+ ++ + ++ P+SGL++RDR+WLKIT+PNAF+GS++VDWLY H+EGF +R+EARKYA+ LLK G I+HTVNK+TFSEQCYYV G+
Sbjct:  400 STITSGSSLPDG---CEGRGLSVHTDMASVTKAMAAPESGLEVRDRMWLKITIPNAFLGSDVVDWLYHHVEGFPERREARKYASGLLKAGLIRHTVNKITFSEQCYYVFGD 507          

HSP 3 Score: 126.331 bits (316), Expect = 5.765e-29
Identity = 53/81 (65.43%), Postives = 69/81 (85.19%), Query Frame = 2
Query:  104 ETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALNRPH-YKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAE 343
            ET++IYH+DEEETPYL+K+ +  +++TLGD K+ L RP   KYFFKSMD DFGVVKEEI+DD A+LPCF GRV+SWLV+++
Sbjct:   13 ETKVIYHLDEEETPYLVKIPVPAERITLGDFKSVLQRPAGAKYFFKSMDQDFGVVKEEISDDNARLPCFNGRVVSWLVSSD 93          
BLAST of Dvl-2 vs. Ensembl Human
Match: DVL2 (dishevelled segment polarity protein 2 [Source:HGNC Symbol;Acc:HGNC:3086])

HSP 1 Score: 205.682 bits (522), Expect = 9.299e-55
Identity = 92/126 (73.02%), Postives = 109/126 (86.51%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTA 1228
            LNI+TV LNM+   FLGISIVGQSN+ GDGGIY+GSIMKGGAVA DGRIEPGDM+L+VND++FE+MSNDDAVR LR+ V KPGPI L VAKCWDP+P+ YFT+PR EP++PIDP AWV H+ A+T 
Sbjct:  257 LNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDMNFENMSNDDAVRVLRDIVHKPGPIVLTVAKCWDPSPQAYFTLPRNEPIQPIDPAAWVSHSAALTG 382          

HSP 2 Score: 150.984 bits (380), Expect = 7.126e-37
Identity = 64/111 (57.66%), Postives = 90/111 (81.08%), Query Frame = 2
Query: 1505 SIVTTSSSLPESERYQEELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGN 1837
            S +T+ SSLP+     E   L+ +TD+ ++ + ++ P+SGL++RDR+WLKIT+PNAF+GS++VDWLY H+EGF +R+EARKYA+ LLK G I+HTVNK+TFSEQCYYV G+
Sbjct:  394 STITSGSSLPDG---CEGRGLSVHTDMASVTKAMAAPESGLEVRDRMWLKITIPNAFLGSDVVDWLYHHVEGFPERREARKYASGLLKAGLIRHTVNKITFSEQCYYVFGD 501          

HSP 3 Score: 125.946 bits (315), Expect = 6.371e-29
Identity = 53/81 (65.43%), Postives = 69/81 (85.19%), Query Frame = 2
Query:  104 ETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALNRPH-YKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAE 343
            ET++IYH+DEEETPYL+K+ +  +++TLGD K+ L RP   KYFFKSMD DFGVVKEEI+DD A+LPCF GRV+SWLV+++
Sbjct:   13 ETKVIYHLDEEETPYLVKIPVPAERITLGDFKSVLQRPAGAKYFFKSMDQDFGVVKEEISDDNARLPCFNGRVVSWLVSSD 93          
BLAST of Dvl-2 vs. Ensembl Human
Match: DVL1 (dishevelled segment polarity protein 1 [Source:HGNC Symbol;Acc:HGNC:3084])

HSP 1 Score: 204.527 bits (519), Expect = 1.484e-54
Identity = 93/127 (73.23%), Postives = 107/127 (84.25%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTAG 1231
            LNIVTV LNM+   FLGISIVGQSN  GDGGIY+GSIMKGGAVA DGRIEPGDM+L+VND++FE+MSNDDAVR LRE V + GPI+L VAKCWDP P+ YFT+PR +PVRPIDP AW+ HT A+T  
Sbjct:  247 LNIVTVTLNMERHHFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLREIVSQTGPISLTVAKCWDPTPRSYFTVPRADPVRPIDPAAWLSHTAALTGA 373          

HSP 2 Score: 155.221 bits (391), Expect = 2.704e-38
Identity = 70/128 (54.69%), Postives = 96/128 (75.00%), Query Frame = 2
Query: 1553 EELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRLSLDQVESVSEVGVNGPHHLAALPPP 1936
            EE  LT  +D+  ++RV+  PDSGL+IRDR+WLKIT+ NA IG+++VDWLY H+EGF +R+EARKYA++LLK G+++HTVNK+TFSEQCYYV G+   N++ L+L+   S    G +    LA LP P
Sbjct:  405 EEAPLTVKSDMSAVVRVMQLPDSGLEIRDRMWLKITIANAVIGADVVDWLYTHVEGFKERREARKYASSLLKHGFLRHTVNKITFSEQCYYVFGDLCSNLATLNLNSGSS----GTSDQDTLAPLPHP 528          

HSP 3 Score: 135.191 bits (339), Expect = 7.319e-32
Identity = 62/85 (72.94%), Postives = 72/85 (84.71%), Query Frame = 2
Query:  104 ETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNAL-NRP--HYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGS 349
            ET+IIYH+DEEETPYL+KL ++P++VTL D KN L NRP   YK+FFKSMD DFGVVKEEI DD AKLPCF GRV+SWLV AEG+
Sbjct:    3 ETKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDFGVVKEEIFDDNAKLPCFNGRVVSWLVLAEGA 87          
BLAST of Dvl-2 vs. Ensembl Celegans
Match: dsh-1 (DiSHevelled related [Source:UniProtKB/TrEMBL;Acc:A0A0K3AWU4])

HSP 1 Score: 163.696 bits (413), Expect = 4.585e-43
Identity = 82/127 (64.57%), Postives = 99/127 (77.95%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIP---RQEPVRPIDPRAWVLHTNAM 1222
            L+++TV LNMDTV FLGISIVGQ++  GD GIYV +IMKGGAVA DGRIE GDMIL+VN+ SFE+ +ND AV  LRE V + GPI L VAK ++ N +  FTIP   R+EPVRPID +AW+ HTNAM
Sbjct:  103 LDVITVNLNMDTVNFLGISIVGQTSNCGDNGIYVANIMKGGAVALDGRIEAGDMILQVNETSFENFTNDQAVDVLREAVSRRGPIKLTVAKSFE-NGQSCFTIPRNSREEPVRPIDTQAWIQHTNAM 228          

HSP 2 Score: 125.946 bits (315), Expect = 2.444e-30
Identity = 61/137 (44.53%), Postives = 90/137 (65.69%), Query Frame = 2
Query: 1466 PMGMPGQFSQG---AGSIVTTSSSLPESERYQEELH--LTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRL 1861
            P  +PG++  G   + S VT++ S  ++       H  L  +TD   ++ +++ P SGLDI++R WLKI +P +F+GS+LV+WL  H+EG  +RK AR +AA+LLK  YI H VNKVTF+EQCYYVLG+   + +R 
Sbjct:  240 PTPIPGEWPHGRPPSSSTVTSNGSNGQNTVVGGGAHIILDIHTDKKKVVEIMAMPGSGLDIKNRTWLKIPIPMSFLGSDLVEWLLDHVEGLRERKTARNFAADLLKLKYIAHVVNKVTFTEQCYYVLGDECSDYARF 376          
BLAST of Dvl-2 vs. Ensembl Celegans
Match: dsh-1 (DiSHevelled related [Source:UniProtKB/TrEMBL;Acc:A0A0K3AWU4])

HSP 1 Score: 164.081 bits (414), Expect = 1.135e-42
Identity = 82/127 (64.57%), Postives = 99/127 (77.95%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIP---RQEPVRPIDPRAWVLHTNAM 1222
            L+++TV LNMDTV FLGISIVGQ++  GD GIYV +IMKGGAVA DGRIE GDMIL+VN+ SFE+ +ND AV  LRE V + GPI L VAK ++ N +  FTIP   R+EPVRPID +AW+ HTNAM
Sbjct:  103 LDVITVNLNMDTVNFLGISIVGQTSNCGDNGIYVANIMKGGAVALDGRIEAGDMILQVNETSFENFTNDQAVDVLREAVSRRGPIKLTVAKSFE-NGQSCFTIPRNSREEPVRPIDTQAWIQHTNAM 228          

HSP 2 Score: 125.946 bits (315), Expect = 5.400e-30
Identity = 61/137 (44.53%), Postives = 90/137 (65.69%), Query Frame = 2
Query: 1466 PMGMPGQFSQG---AGSIVTTSSSLPESERYQEELH--LTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRL 1861
            P  +PG++  G   + S VT++ S  ++       H  L  +TD   ++ +++ P SGLDI++R WLKI +P +F+GS+LV+WL  H+EG  +RK AR +AA+LLK  YI H VNKVTF+EQCYYVLG+   + +R 
Sbjct:  240 PTPIPGEWPHGRPPSSSTVTSNGSNGQNTVVGGGAHIILDIHTDKKKVVEIMAMPGSGLDIKNRTWLKIPIPMSFLGSDLVEWLLDHVEGLRERKTARNFAADLLKLKYIAHVVNKVTFTEQCYYVLGDECSDYARF 376          
BLAST of Dvl-2 vs. Ensembl Celegans
Match: dsh-1 (DiSHevelled related [Source:UniProtKB/TrEMBL;Acc:A0A0K3AWU4])

HSP 1 Score: 164.081 bits (414), Expect = 6.731e-42
Identity = 82/127 (64.57%), Postives = 99/127 (77.95%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIP---RQEPVRPIDPRAWVLHTNAM 1222
            L+++TV LNMDTV FLGISIVGQ++  GD GIYV +IMKGGAVA DGRIE GDMIL+VN+ SFE+ +ND AV  LRE V + GPI L VAK ++ N +  FTIP   R+EPVRPID +AW+ HTNAM
Sbjct:  299 LDVITVNLNMDTVNFLGISIVGQTSNCGDNGIYVANIMKGGAVALDGRIEAGDMILQVNETSFENFTNDQAVDVLREAVSRRGPIKLTVAKSFE-NGQSCFTIPRNSREEPVRPIDTQAWIQHTNAM 424          

HSP 2 Score: 125.561 bits (314), Expect = 1.966e-29
Identity = 61/137 (44.53%), Postives = 90/137 (65.69%), Query Frame = 2
Query: 1466 PMGMPGQFSQG---AGSIVTTSSSLPESERYQEELH--LTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRL 1861
            P  +PG++  G   + S VT++ S  ++       H  L  +TD   ++ +++ P SGLDI++R WLKI +P +F+GS+LV+WL  H+EG  +RK AR +AA+LLK  YI H VNKVTF+EQCYYVLG+   + +R 
Sbjct:  436 PTPIPGEWPHGRPPSSSTVTSNGSNGQNTVVGGGAHIILDIHTDKKKVVEIMAMPGSGLDIKNRTWLKIPIPMSFLGSDLVEWLLDHVEGLRERKTARNFAADLLKLKYIAHVVNKVTFTEQCYYVLGDECSDYARF 572          

HSP 3 Score: 73.559 bits (179), Expect = 5.153e-13
Identity = 39/87 (44.83%), Postives = 56/87 (64.37%), Query Frame = 2
Query:  107 TRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALNRPHYKYFFKSMDDDFGV-VKEEITDDEAKL-PCFKGRVISWLVTAEGSTVSD 361
            T++  HID+E  PY++++ + PD +TLGDLK  L R ++KY+ K++D D G  VK EI DD  +L P        +L+T EGST SD
Sbjct:   72 TKVYCHIDDETDPYMLEVHVPPDLITLGDLKRVLMRTNFKYYRKALDPDSGYEVKAEIRDDSQRLTPSPNNLFELFLLTIEGSTHSD 158          
BLAST of Dvl-2 vs. Ensembl Celegans
Match: dsh-1 (DiSHevelled related [Source:UniProtKB/TrEMBL;Acc:A0A0K3AWU4])

HSP 1 Score: 164.466 bits (415), Expect = 9.258e-42
Identity = 82/127 (64.57%), Postives = 99/127 (77.95%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIP---RQEPVRPIDPRAWVLHTNAM 1222
            L+++TV LNMDTV FLGISIVGQ++  GD GIYV +IMKGGAVA DGRIE GDMIL+VN+ SFE+ +ND AV  LRE V + GPI L VAK ++ N +  FTIP   R+EPVRPID +AW+ HTNAM
Sbjct:  299 LDVITVNLNMDTVNFLGISIVGQTSNCGDNGIYVANIMKGGAVALDGRIEAGDMILQVNETSFENFTNDQAVDVLREAVSRRGPIKLTVAKSFE-NGQSCFTIPRNSREEPVRPIDTQAWIQHTNAM 424          

HSP 2 Score: 125.946 bits (315), Expect = 2.559e-29
Identity = 61/137 (44.53%), Postives = 90/137 (65.69%), Query Frame = 2
Query: 1466 PMGMPGQFSQG---AGSIVTTSSSLPESERYQEELH--LTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRL 1861
            P  +PG++  G   + S VT++ S  ++       H  L  +TD   ++ +++ P SGLDI++R WLKI +P +F+GS+LV+WL  H+EG  +RK AR +AA+LLK  YI H VNKVTF+EQCYYVLG+   + +R 
Sbjct:  436 PTPIPGEWPHGRPPSSSTVTSNGSNGQNTVVGGGAHIILDIHTDKKKVVEIMAMPGSGLDIKNRTWLKIPIPMSFLGSDLVEWLLDHVEGLRERKTARNFAADLLKLKYIAHVVNKVTFTEQCYYVLGDECSDYARF 572          

HSP 3 Score: 73.559 bits (179), Expect = 4.715e-13
Identity = 39/87 (44.83%), Postives = 56/87 (64.37%), Query Frame = 2
Query:  107 TRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALNRPHYKYFFKSMDDDFGV-VKEEITDDEAKL-PCFKGRVISWLVTAEGSTVSD 361
            T++  HID+E  PY++++ + PD +TLGDLK  L R ++KY+ K++D D G  VK EI DD  +L P        +L+T EGST SD
Sbjct:   72 TKVYCHIDDETDPYMLEVHVPPDLITLGDLKRVLMRTNFKYYRKALDPDSGYEVKAEIRDDSQRLTPSPNNLFELFLLTIEGSTHSD 158          
BLAST of Dvl-2 vs. Ensembl Celegans
Match: dsh-1 (DiSHevelled related [Source:UniProtKB/TrEMBL;Acc:A0A0K3AWU4])

HSP 1 Score: 166.007 bits (419), Expect = 1.092e-41
Identity = 82/127 (64.57%), Postives = 99/127 (77.95%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIP---RQEPVRPIDPRAWVLHTNAM 1222
            L+++TV LNMDTV FLGISIVGQ++  GD GIYV +IMKGGAVA DGRIE GDMIL+VN+ SFE+ +ND AV  LRE V + GPI L VAK ++ N +  FTIP   R+EPVRPID +AW+ HTNAM
Sbjct:  578 LDVITVNLNMDTVNFLGISIVGQTSNCGDNGIYVANIMKGGAVALDGRIEAGDMILQVNETSFENFTNDQAVDVLREAVSRRGPIKLTVAKSFE-NGQSCFTIPRNSREEPVRPIDTQAWIQHTNAM 703          

HSP 2 Score: 126.331 bits (316), Expect = 3.260e-29
Identity = 61/137 (44.53%), Postives = 90/137 (65.69%), Query Frame = 2
Query: 1466 PMGMPGQFSQG---AGSIVTTSSSLPESERYQEELH--LTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRL 1861
            P  +PG++  G   + S VT++ S  ++       H  L  +TD   ++ +++ P SGLDI++R WLKI +P +F+GS+LV+WL  H+EG  +RK AR +AA+LLK  YI H VNKVTF+EQCYYVLG+   + +R 
Sbjct:  715 PTPIPGEWPHGRPPSSSTVTSNGSNGQNTVVGGGAHIILDIHTDKKKVVEIMAMPGSGLDIKNRTWLKIPIPMSFLGSDLVEWLLDHVEGLRERKTARNFAADLLKLKYIAHVVNKVTFTEQCYYVLGDECSDYARF 851          
BLAST of Dvl-2 vs. Ensembl Fly
Match: dsh (gene:FBgn0000499 transcript:FBtr0073454)

HSP 1 Score: 226.868 bits (577), Expect = 5.076e-63
Identity = 104/129 (80.62%), Postives = 116/129 (89.92%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTAGAS 1237
            LNI+TV +NM+ V FLGISIVGQSN+GGDGGIYVGSIMKGGAVA DGRIEPGDMIL+VND++FE+M+ND+AVR LRE VQKPGPI LVVAKCWDPNPKGYFTIPR EPVRPIDP AWV HT A+T+  S
Sbjct:  248 LNIITVSINMEAVNFLGISIVGQSNRGGDGGIYVGSIMKGGAVALDGRIEPGDMILQVNDVNFENMTNDEAVRVLREVVQKPGPIKLVVAKCWDPNPKGYFTIPRTEPVRPIDPGAWVAHTQALTSHDS 376          

HSP 2 Score: 122.479 bits (306), Expect = 2.685e-28
Identity = 57/89 (64.04%), Postives = 69/89 (77.53%), Query Frame = 2
Query:  104 ETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALNRPH--YKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGSTVSDN 364
            ET++IYHID+E TPYL+K+ I   +VTL D K  LN+ +  YKYFFKSMD DFGVVKEEI DD   LPCF GRV+SWLV+A+G+  SDN
Sbjct:   10 ETKVIYHIDDETTPYLVKIPIPSAQVTLRDFKLVLNKQNNNYKYFFKSMDADFGVVKEEIADDSTILPCFNGRVVSWLVSADGTNQSDN 98          

HSP 3 Score: 119.013 bits (297), Expect = 3.231e-27
Identity = 47/80 (58.75%), Postives = 68/80 (85.00%), Query Frame = 2
Query: 1592 ILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVL 1831
            I++ +++PDSGL+IRDR+WLKIT+PNAFIG++ V+W+  ++E   DR+EAR+  + +L+  YIKHTVNK+TFSEQCYYV+
Sbjct:  397 IVKAMTKPDSGLEIRDRMWLKITIPNAFIGADAVNWVLENVEDVQDRREARRIVSAMLRSNYIKHTVNKLTFSEQCYYVV 476          
BLAST of Dvl-2 vs. Ensembl Fly
Match: baz (gene:FBgn0000163 transcript:FBtr0111000)

HSP 1 Score: 53.1434 bits (126), Expect = 1.514e-6
Identity = 26/69 (37.68%), Postives = 42/69 (60.87%), Query Frame = 2
Query:  932 GDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQV-----QKPGPINLVVAK 1123
            GD GI+V +++ GGA ++DGR+   D +L VN +S    +N +A+ TLR  +     + PG I L+V +
Sbjct:  687 GDLGIFVKNVIHGGAASRDGRLRMNDQLLSVNGVSLRGQNNAEAMETLRRAMVNTPGKHPGTITLLVGR 755          
BLAST of Dvl-2 vs. Ensembl Fly
Match: baz (gene:FBgn0000163 transcript:FBtr0343763)

HSP 1 Score: 53.1434 bits (126), Expect = 1.672e-6
Identity = 26/69 (37.68%), Postives = 42/69 (60.87%), Query Frame = 2
Query:  932 GDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQV-----QKPGPINLVVAK 1123
            GD GI+V +++ GGA ++DGR+   D +L VN +S    +N +A+ TLR  +     + PG I L+V +
Sbjct:  666 GDLGIFVKNVIHGGAASRDGRLRMNDQLLSVNGVSLRGQNNAEAMETLRRAMVNTPGKHPGTITLLVGR 734          
BLAST of Dvl-2 vs. Ensembl Fly
Match: baz (gene:FBgn0000163 transcript:FBtr0343764)

HSP 1 Score: 53.1434 bits (126), Expect = 1.757e-6
Identity = 26/69 (37.68%), Postives = 42/69 (60.87%), Query Frame = 2
Query:  932 GDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQV-----QKPGPINLVVAK 1123
            GD GI+V +++ GGA ++DGR+   D +L VN +S    +N +A+ TLR  +     + PG I L+V +
Sbjct:  687 GDLGIFVKNVIHGGAASRDGRLRMNDQLLSVNGVSLRGQNNAEAMETLRRAMVNTPGKHPGTITLLVGR 755          
BLAST of Dvl-2 vs. Ensembl Fly
Match: baz (gene:FBgn0000163 transcript:FBtr0074388)

HSP 1 Score: 53.1434 bits (126), Expect = 1.782e-6
Identity = 26/69 (37.68%), Postives = 42/69 (60.87%), Query Frame = 2
Query:  932 GDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQV-----QKPGPINLVVAK 1123
            GD GI+V +++ GGA ++DGR+   D +L VN +S    +N +A+ TLR  +     + PG I L+V +
Sbjct:  666 GDLGIFVKNVIHGGAASRDGRLRMNDQLLSVNGVSLRGQNNAEAMETLRRAMVNTPGKHPGTITLLVGR 734          
BLAST of Dvl-2 vs. Ensembl Zebrafish
Match: dvl1a (dishevelled segment polarity protein 1a [Source:ZFIN;Acc:ZDB-GENE-090312-40])

HSP 1 Score: 210.69 bits (535), Expect = 9.515e-58
Identity = 94/126 (74.60%), Postives = 109/126 (86.51%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTA 1228
            LNI+TV LNM+   FLGISIVGQSN  GDGGIY+GSIMKGGAVA DGRIEPGDM+L+VN+++FE+MSNDDAVR LRE V KPGPI+L VAKCWDP+P+ YFTIPR EPVRPIDP AW+ HT A++ 
Sbjct:   90 LNIITVTLNMEKYNFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNEVNFENMSNDDAVRILREIVSKPGPISLTVAKCWDPSPRSYFTIPRAEPVRPIDPAAWITHTTALSG 215          

HSP 2 Score: 154.066 bits (388), Expect = 1.100e-38
Identity = 79/163 (48.47%), Postives = 110/163 (67.48%), Query Frame = 2
Query: 1454 FFGYPMGMPGQFSQGAGSIV-TTSSSLPESERYQEELHLT-KNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRLSLDQVESVSEVGVNGPHHLAALPPP 1936
            +F  P   P +    A  I  TT+ S P      ++L L+   TD+ TI++V+  PDSGL+IRDR+WLKIT+ NA IG+++VDWL+  +EGF DR++ARKYA++LLK GY++HTVNK+TFSEQCYY  G+   NM+ L+L++  S      +G   LA LPPP
Sbjct:  189 YFTIPRAEPVRPIDPAAWITHTTALSGPYPHYEFDDLPLSVSKTDMATIVKVMQLPDSGLEIRDRMWLKITIANAVIGADVVDWLFSRVEGFKDRRDARKYASSLLKHGYLRHTVNKITFSEQCYYTFGDLCQNMASLNLNEGSSGGGSDQDG---LAPLPPP 348          
BLAST of Dvl-2 vs. Ensembl Zebrafish
Match: dvl2 (dishevelled segment polarity protein 2 [Source:ZFIN;Acc:ZDB-GENE-041118-20])

HSP 1 Score: 213.772 bits (543), Expect = 1.576e-57
Identity = 96/127 (75.59%), Postives = 110/127 (86.61%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTAG 1231
            LNI+TV LNM+   FLGISIVGQSN+ GDGGIY+GSIMKGGAVA DGRIEPGDM+L+VNDI+FE+MSNDDAVR LRE V KPGPI L VAKCWDP+P+GYFT+PR EP+RPIDP AWV H+ A+T  
Sbjct:  249 LNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDINFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPQGYFTLPRNEPIRPIDPAAWVNHSVALTGA 375          

HSP 2 Score: 155.221 bits (391), Expect = 2.101e-38
Identity = 71/135 (52.59%), Postives = 102/135 (75.56%), Query Frame = 2
Query: 1541 ERYQEELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLG---NTTLNMSRLSLDQVESVSEVGVNGPHHLAALPPP 1936
            ER+ +E +L+  +D+ ++ + ++ P+SGL++RDR+WLKIT+PNAF+GS++V+WLY HI+GF DR+EARKYA+NLLK G+I+HTVNK+TFSEQCYY+ G   N    M+ LSL+  +  S  G +    LA LP P
Sbjct:  394 ERF-DEFNLSLRSDMASVAKAMASPESGLEVRDRMWLKITIPNAFLGSDVVEWLYHHIDGFQDRREARKYASNLLKAGFIRHTVNKITFSEQCYYIFGDFSNCENYMANLSLNDNDGSS--GASDQDTLAPLPLP 525          

HSP 3 Score: 135.191 bits (339), Expect = 5.849e-32
Identity = 57/80 (71.25%), Postives = 71/80 (88.75%), Query Frame = 2
Query:  104 ETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALNRPHYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAE 343
            ET+IIYHIDEEETPYL+K+ I+ +K+TL D K  LN+P+YK+FFKSMD DFGVVKEEI+DD AKLPCF GRV+SWLV+++
Sbjct:    3 ETKIIYHIDEEETPYLVKIPIAAEKITLLDFKQVLNKPNYKFFFKSMDQDFGVVKEEISDDSAKLPCFNGRVVSWLVSSD 82          
BLAST of Dvl-2 vs. Ensembl Zebrafish
Match: dvl3b (dishevelled segment polarity protein 3b [Source:ZFIN;Acc:ZDB-GENE-121101-2])

HSP 1 Score: 212.616 bits (540), Expect = 2.143e-57
Identity = 97/127 (76.38%), Postives = 108/127 (85.04%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTAG 1231
            LNI+TV LNM+   FLGISIVGQSN+ GDGGIY+GSIMKGGAVA DGRIEPGDM+L+VNDI+FE+MSNDDAVR LRE V KPGPI L VAKCWDPNP+  FT+PR EP+RPIDP AWV HT AMT  
Sbjct:  255 LNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDINFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPNPRSCFTLPRSEPIRPIDPAAWVSHTAAMTGA 381          

HSP 2 Score: 168.318 bits (425), Expect = 9.434e-43
Identity = 74/134 (55.22%), Postives = 104/134 (77.61%), Query Frame = 2
Query: 1535 ESERYQEELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRLSLDQVESVSEVGVNGPHHLAALPPP 1936
            E+ER+ E+ HL+ ++D+  + + ++ P+SGL++RDR+WLKIT+PNAFIGS++VDWLY  +EGF+DR+EARKYA+NLLK GYI+HTVNK+TFSEQCYY+ G+   NM+ L+L   +  S  G +    LA LP P
Sbjct:  407 ETERF-EDFHLSIHSDMAAVAKAMASPESGLEVRDRMWLKITIPNAFIGSDVVDWLYHRVEGFTDRREARKYASNLLKAGYIRHTVNKITFSEQCYYIFGDVCGNMASLTLHDHDGSS--GASDQDTLAPLPHP 537          

HSP 3 Score: 144.05 bits (362), Expect = 7.667e-35
Identity = 64/86 (74.42%), Postives = 75/86 (87.21%), Query Frame = 2
Query:  104 ETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALNRPHYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGSTVSD 361
            ET+IIYH+DE+ETPYLIKL I  + VTL D KN LN+P+YK+FFKSMDDDFGVVKEEI+DD AKLPCF GRV+SWLV+A+GS  SD
Sbjct:    3 ETKIIYHLDEQETPYLIKLPIPAENVTLADFKNVLNKPNYKFFFKSMDDDFGVVKEEISDDNAKLPCFNGRVVSWLVSADGSHGSD 88          
BLAST of Dvl-2 vs. Ensembl Zebrafish
Match: dvl1b (dishevelled segment polarity protein 1b [Source:ZFIN;Acc:ZDB-GENE-071004-1])

HSP 1 Score: 209.534 bits (532), Expect = 1.937e-56
Identity = 95/126 (75.40%), Postives = 108/126 (85.71%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTA 1228
            LNI+TV LNM+   FLGISIVGQSN  GDGGIY+GSIMKGGAVA DGRIEPGDM+L+VND++FE+MSNDDAVR LRE V K GPI+L VAKCWDP+P+ YFTIPR EPVRPIDP AW+ HT A+T 
Sbjct:  241 LNIITVTLNMEKYNFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRILREIVSKNGPISLTVAKCWDPSPRSYFTIPRAEPVRPIDPAAWISHTTALTG 366          

HSP 2 Score: 154.066 bits (388), Expect = 4.231e-38
Identity = 86/174 (49.43%), Postives = 117/174 (67.24%), Query Frame = 2
Query: 1454 FFGYPMGMPGQFSQGAGSIVTTSS---SLPESERYQEELHLTK-NTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRLSLDQVESVSEVGVNGPHHLAALPPPNFSSNKQPI 1963
            +F  P   P +    A  I  T++   S P++E   +EL LT   TD+ TI++V+  PDSGL+IRDR+WLKIT+ NA IG ++VDWLY  +EGF DR++ARKYA++LLK GY++HTVNK+TFSEQCYY  G+   NM+ L+L+  E  S  G +    LA LPPP  S+N  P+
Sbjct:  340 YFTIPRAEPVRPIDPAAWISHTTALTGSYPQNEF--DELPLTMGKTDMATIVKVMQLPDSGLEIRDRMWLKITIANAVIGGDVVDWLYSRVEGFKDRRDARKYASSLLKHGYLRHTVNKITFSEQCYYTFGDLCQNMATLNLN--EGSSGAG-SEQDTLAPLPPP--STNPWPM 506          

HSP 3 Score: 138.272 bits (347), Expect = 4.702e-33
Identity = 64/85 (75.29%), Postives = 73/85 (85.88%), Query Frame = 2
Query:  104 ETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNAL-NRP--HYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGS 349
            ET+IIYHIDEEETPYL+KLS++P+KVTL D KN L NRP   YK+FFKSMD DFGVVKEE++DD AKLPCF GRV+SWLV AE S
Sbjct:    3 ETKIIYHIDEEETPYLVKLSVAPEKVTLADFKNVLSNRPVNSYKFFFKSMDQDFGVVKEEVSDDNAKLPCFNGRVVSWLVLAESS 87          
BLAST of Dvl-2 vs. Ensembl Zebrafish
Match: dvl1b (dishevelled segment polarity protein 1b [Source:ZFIN;Acc:ZDB-GENE-071004-1])

HSP 1 Score: 209.534 bits (532), Expect = 2.376e-56
Identity = 95/126 (75.40%), Postives = 108/126 (85.71%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTA 1228
            LNI+TV LNM+   FLGISIVGQSN  GDGGIY+GSIMKGGAVA DGRIEPGDM+L+VND++FE+MSNDDAVR LRE V K GPI+L VAKCWDP+P+ YFTIPR EPVRPIDP AW+ HT A+T 
Sbjct:  250 LNIITVTLNMEKYNFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRILREIVSKNGPISLTVAKCWDPSPRSYFTIPRAEPVRPIDPAAWISHTTALTG 375          

HSP 2 Score: 154.066 bits (388), Expect = 4.902e-38
Identity = 86/174 (49.43%), Postives = 117/174 (67.24%), Query Frame = 2
Query: 1454 FFGYPMGMPGQFSQGAGSIVTTSS---SLPESERYQEELHLTK-NTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRLSLDQVESVSEVGVNGPHHLAALPPPNFSSNKQPI 1963
            +F  P   P +    A  I  T++   S P++E   +EL LT   TD+ TI++V+  PDSGL+IRDR+WLKIT+ NA IG ++VDWLY  +EGF DR++ARKYA++LLK GY++HTVNK+TFSEQCYY  G+   NM+ L+L+  E  S  G +    LA LPPP  S+N  P+
Sbjct:  349 YFTIPRAEPVRPIDPAAWISHTTALTGSYPQNEF--DELPLTMGKTDMATIVKVMQLPDSGLEIRDRMWLKITIANAVIGGDVVDWLYSRVEGFKDRRDARKYASSLLKHGYLRHTVNKITFSEQCYYTFGDLCQNMATLNLN--EGSSGAG-SEQDTLAPLPPP--STNPWPM 515          

HSP 3 Score: 138.272 bits (347), Expect = 5.073e-33
Identity = 64/85 (75.29%), Postives = 73/85 (85.88%), Query Frame = 2
Query:  104 ETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNAL-NRP--HYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGS 349
            ET+IIYHIDEEETPYL+KLS++P+KVTL D KN L NRP   YK+FFKSMD DFGVVKEE++DD AKLPCF GRV+SWLV AE S
Sbjct:    3 ETKIIYHIDEEETPYLVKLSVAPEKVTLADFKNVLSNRPVNSYKFFFKSMDQDFGVVKEEVSDDNAKLPCFNGRVVSWLVLAESS 87          
BLAST of Dvl-2 vs. Ensembl Xenopus
Match: dvl1 (dishevelled segment polarity protein 1 [Source:NCBI gene;Acc:100144639])

HSP 1 Score: 212.616 bits (540), Expect = 2.730e-58
Identity = 96/127 (75.59%), Postives = 109/127 (85.83%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTAG 1231
            LNI+TV LNM+   FLGISIVGQSN  GDGGIY+GSIMKGGAVA DGRIEPGDM+L+VND++FE+MSNDDAVR LRE V KPGPI+L VAKCWDP P+ YFTIPR EPVRPIDP AW+ HT+A+T  
Sbjct:  249 LNIITVTLNMEKYNFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLREIVSKPGPISLTVAKCWDPTPRSYFTIPRAEPVRPIDPAAWITHTSALTGA 375          

HSP 2 Score: 159.073 bits (401), Expect = 3.900e-40
Identity = 74/135 (54.81%), Postives = 104/135 (77.04%), Query Frame = 2
Query: 1532 PESERYQEELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRLSLDQVESVSEVGVNGPHHLAALPPP 1936
            PESE+ QE+  L+  +D+ TI++V+  PDSGL+IRDR+WLKIT+ NA IG+++VDWLY H+EGF +R+EARKYA+++LK GY++HTVNK+TFSEQCYYV G+   N++ L+L++  S    G +    LA LP P
Sbjct:  400 PESEK-QEDSPLSVKSDMATIVKVMQLPDSGLEIRDRMWLKITISNAVIGADVVDWLYTHVEGFKERREARKYASSMLKHGYLRHTVNKITFSEQCYYVFGDLCGNVAALNLNEGSS----GTSDQDTLAPLPHP 529          

HSP 3 Score: 137.887 bits (346), Expect = 3.247e-33
Identity = 65/85 (76.47%), Postives = 72/85 (84.71%), Query Frame = 2
Query:  104 ETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNAL-NRP--HYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGS 349
            ET+IIYHIDEEETPYL+KL + P+KVTL D KN L NRP  HYK+FFKSMD DFGVVKEEI+DD AKLPCF GRV+SWLV AE S
Sbjct:    3 ETKIIYHIDEEETPYLVKLPVPPEKVTLADFKNVLSNRPVHHYKFFFKSMDQDFGVVKEEISDDNAKLPCFNGRVVSWLVLAESS 87          
BLAST of Dvl-2 vs. Ensembl Xenopus
Match: dvl1 (dishevelled segment polarity protein 1 [Source:NCBI gene;Acc:100144639])

HSP 1 Score: 212.231 bits (539), Expect = 2.817e-57
Identity = 96/127 (75.59%), Postives = 109/127 (85.83%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTAG 1231
            LNI+TV LNM+   FLGISIVGQSN  GDGGIY+GSIMKGGAVA DGRIEPGDM+L+VND++FE+MSNDDAVR LRE V KPGPI+L VAKCWDP P+ YFTIPR EPVRPIDP AW+ HT+A+T  
Sbjct:  234 LNIITVTLNMEKYNFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLREIVSKPGPISLTVAKCWDPTPRSYFTIPRAEPVRPIDPAAWITHTSALTGA 360          

HSP 2 Score: 158.688 bits (400), Expect = 1.518e-39
Identity = 74/135 (54.81%), Postives = 104/135 (77.04%), Query Frame = 2
Query: 1532 PESERYQEELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRLSLDQVESVSEVGVNGPHHLAALPPP 1936
            PESE+ QE+  L+  +D+ TI++V+  PDSGL+IRDR+WLKIT+ NA IG+++VDWLY H+EGF +R+EARKYA+++LK GY++HTVNK+TFSEQCYYV G+   N++ L+L++  S    G +    LA LP P
Sbjct:  385 PESEK-QEDSPLSVKSDMATIVKVMQLPDSGLEIRDRMWLKITISNAVIGADVVDWLYTHVEGFKERREARKYASSMLKHGYLRHTVNKITFSEQCYYVFGDLCGNVAALNLNEGSS----GTSDQDTLAPLPHP 514          

HSP 3 Score: 139.428 bits (350), Expect = 2.530e-33
Identity = 66/85 (77.65%), Postives = 72/85 (84.71%), Query Frame = 2
Query:  104 ETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNAL-NRP--HYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGS 349
            ETRIIYHIDEEETPYL+KL + P+KVTL D KN L NRP  HYK+FFKSMD DFGVVKEEI+DD AKLPCF GRV+SWLV AE S
Sbjct:    3 ETRIIYHIDEEETPYLVKLPVPPEKVTLADFKNVLSNRPVHHYKFFFKSMDQDFGVVKEEISDDNAKLPCFNGRVVSWLVLAESS 87          
BLAST of Dvl-2 vs. Ensembl Xenopus
Match: dvl1 (dishevelled segment polarity protein 1 [Source:NCBI gene;Acc:100144639])

HSP 1 Score: 212.231 bits (539), Expect = 4.266e-57
Identity = 96/127 (75.59%), Postives = 109/127 (85.83%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTAG 1231
            LNI+TV LNM+   FLGISIVGQSN  GDGGIY+GSIMKGGAVA DGRIEPGDM+L+VND++FE+MSNDDAVR LRE V KPGPI+L VAKCWDP P+ YFTIPR EPVRPIDP AW+ HT+A+T  
Sbjct:  249 LNIITVTLNMEKYNFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLREIVSKPGPISLTVAKCWDPTPRSYFTIPRAEPVRPIDPAAWITHTSALTGA 375          

HSP 2 Score: 159.073 bits (401), Expect = 1.590e-39
Identity = 74/135 (54.81%), Postives = 104/135 (77.04%), Query Frame = 2
Query: 1532 PESERYQEELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRLSLDQVESVSEVGVNGPHHLAALPPP 1936
            PESE+ QE+  L+  +D+ TI++V+  PDSGL+IRDR+WLKIT+ NA IG+++VDWLY H+EGF +R+EARKYA+++LK GY++HTVNK+TFSEQCYYV G+   N++ L+L++  S    G +    LA LP P
Sbjct:  400 PESEK-QEDSPLSVKSDMATIVKVMQLPDSGLEIRDRMWLKITISNAVIGADVVDWLYTHVEGFKERREARKYASSMLKHGYLRHTVNKITFSEQCYYVFGDLCGNVAALNLNEGSS----GTSDQDTLAPLPHP 529          

HSP 3 Score: 138.272 bits (347), Expect = 7.856e-33
Identity = 65/85 (76.47%), Postives = 72/85 (84.71%), Query Frame = 2
Query:  104 ETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNAL-NRP--HYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGS 349
            ET+IIYHIDEEETPYL+KL + P+KVTL D KN L NRP  HYK+FFKSMD DFGVVKEEI+DD AKLPCF GRV+SWLV AE S
Sbjct:    3 ETKIIYHIDEEETPYLVKLPVPPEKVTLADFKNVLSNRPVHHYKFFFKSMDQDFGVVKEEISDDNAKLPCFNGRVVSWLVLAESS 87          
BLAST of Dvl-2 vs. Ensembl Xenopus
Match: dvl3 (dishevelled segment polarity protein 3 [Source:NCBI gene;Acc:100144702])

HSP 1 Score: 207.994 bits (528), Expect = 5.005e-56
Identity = 95/126 (75.40%), Postives = 107/126 (84.92%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTA 1228
            LNI+TV LNM+   FLGISIVGQSN+ GDGGIY+GSIMKGGAVA DGRIEPGDM+L+VND +FE+MSNDDAVR LRE V KPGPI L VAKCWDP+P+  FT+PR EP+RPIDP AWV HT AMT 
Sbjct:  218 LNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDTNFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPRNCFTLPRSEPIRPIDPAAWVSHTAAMTG 343          

HSP 2 Score: 160.999 bits (406), Expect = 2.055e-40
Identity = 72/128 (56.25%), Postives = 101/128 (78.91%), Query Frame = 2
Query: 1553 EELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRLSLDQVESVSEVGVNGPHHLAALPPP 1936
            ++  L+ ++D+ TI++ +  P+SGL++RDR+WLKIT+PNAFIGS++VDWLY H+EGF+DR+EARKYA+NLLK GYI+HTVNK+TFSEQCYY+ G+   +M+ LSL+  +  S  G +    LA LP P
Sbjct:  351 DDFQLSIHSDMVTIVKAMRSPESGLEVRDRMWLKITIPNAFIGSDVVDWLYHHVEGFTDRREARKYASNLLKAGYIRHTVNKITFSEQCYYIFGD-LCDMANLSLNDHDGSS--GTSDQDTLAPLPHP 475          

HSP 3 Score: 144.05 bits (362), Expect = 6.600e-35
Identity = 64/103 (62.14%), Postives = 82/103 (79.61%), Query Frame = 2
Query:  104 ETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALNRPHYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGSTVSDNVDSNGILDKNESRMLP 412
            ET++IYH+DE+ETPYL+KL +  +KVTLGD KN LN+P+YK+FFKSMDDDFGVVKEEI+DD AKLPCF GRV+ WLV+A+GS      D+  +   N+S + P
Sbjct:    3 ETKVIYHLDEQETPYLVKLPVPAEKVTLGDFKNVLNKPNYKFFFKSMDDDFGVVKEEISDDNAKLPCFNGRVVCWLVSADGS----QSDAGSVCADNQSDLPP 101          
BLAST of Dvl-2 vs. Ensembl Xenopus
Match: dvl3 (dishevelled segment polarity protein 3 [Source:NCBI gene;Acc:100144702])

HSP 1 Score: 208.379 bits (529), Expect = 7.743e-56
Identity = 95/126 (75.40%), Postives = 107/126 (84.92%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTA 1228
            LNI+TV LNM+   FLGISIVGQSN+ GDGGIY+GSIMKGGAVA DGRIEPGDM+L+VND +FE+MSNDDAVR LRE V KPGPI L VAKCWDP+P+  FT+PR EP+RPIDP AWV HT AMT 
Sbjct:  244 LNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDTNFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPRNCFTLPRSEPIRPIDPAAWVSHTAAMTG 369          

HSP 2 Score: 169.474 bits (428), Expect = 7.034e-43
Identity = 76/134 (56.72%), Postives = 106/134 (79.10%), Query Frame = 2
Query: 1535 ESERYQEELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRLSLDQVESVSEVGVNGPHHLAALPPP 1936
            E+ER+ ++  L+ ++D+ TI++ +  P+SGL++RDR+WLKIT+PNAFIGS++VDWLY H+EGF+DR+EARKYA+NLLK GYI+HTVNK+TFSEQCYY+ G+   NM+ LSL+  +  S  G +    LA LP P
Sbjct:  396 ETERF-DDFQLSIHSDMVTIVKAMRSPESGLEVRDRMWLKITIPNAFIGSDVVDWLYHHVEGFTDRREARKYASNLLKAGYIRHTVNKITFSEQCYYIFGDLCGNMANLSLNDHDGSS--GTSDQDTLAPLPHP 526          

HSP 3 Score: 144.436 bits (363), Expect = 9.062e-35
Identity = 64/103 (62.14%), Postives = 82/103 (79.61%), Query Frame = 2
Query:  104 ETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALNRPHYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGSTVSDNVDSNGILDKNESRMLP 412
            ET++IYH+DE+ETPYL+KL +  +KVTLGD KN LN+P+YK+FFKSMDDDFGVVKEEI+DD AKLPCF GRV+ WLV+A+GS      D+  +   N+S + P
Sbjct:    3 ETKVIYHLDEQETPYLVKLPVPAEKVTLGDFKNVLNKPNYKFFFKSMDDDFGVVKEEISDDNAKLPCFNGRVVCWLVSADGS----QSDAGSVCADNQSDLPP 101          
BLAST of Dvl-2 vs. Ensembl Mouse
Match: Dvl3 (dishevelled segment polarity protein 3 [Source:MGI Symbol;Acc:MGI:108100])

HSP 1 Score: 211.075 bits (536), Expect = 9.419e-57
Identity = 96/126 (76.19%), Postives = 109/126 (86.51%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTA 1228
            LNI+TV LNM+   FLGISIVGQSN+ GDGGIY+GSIMKGGAVA DGRIEPGDM+L+VN+I+FE+MSNDDAVR LRE V KPGPI L VAKCWDP+P+G FT+PR EP+RPIDP AWV HT AMT 
Sbjct:  245 LNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNEINFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPRGCFTLPRSEPIRPIDPAAWVSHTAAMTG 370          

HSP 2 Score: 163.696 bits (413), Expect = 3.573e-41
Identity = 73/134 (54.48%), Postives = 105/134 (78.36%), Query Frame = 2
Query: 1535 ESERYQEELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRLSLDQVESVSEVGVNGPHHLAALPPP 1936
            ++ER  ++ HL+ ++D+  I++ ++ P+SGL++RDR+WLKIT+PNAFIGS++VDWLY ++EGF+DR+EARKYA+NLLK G+I+HTVNK+TFSEQCYY+ G+   NM+ LSL   +  S  G +    LA LP P
Sbjct:  397 DTERL-DDFHLSIHSDMAAIVKAMASPESGLEVRDRMWLKITIPNAFIGSDVVDWLYHNVEGFTDRREARKYASNLLKAGFIRHTVNKITFSEQCYYIFGDLCGNMANLSLHDHDGSS--GASDQDTLAPLPHP 527          

HSP 3 Score: 136.346 bits (342), Expect = 2.434e-32
Identity = 59/82 (71.95%), Postives = 70/82 (85.37%), Query Frame = 2
Query:  104 ETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALNRPHYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGS 349
            ET+IIYH+D +ETPYL+KL +  ++VTL D K  L RP YK+FFKSMDDDFGVVKEEI+DD AKLPCF GRV+SWLV+AEGS
Sbjct:    3 ETKIIYHLDGQETPYLVKLPLPAERVTLADFKGVLQRPSYKFFFKSMDDDFGVVKEEISDDNAKLPCFNGRVVSWLVSAEGS 84          
BLAST of Dvl-2 vs. Ensembl Mouse
Match: Dvl3 (dishevelled segment polarity protein 3 [Source:MGI Symbol;Acc:MGI:108100])

HSP 1 Score: 210.69 bits (535), Expect = 1.024e-56
Identity = 96/126 (76.19%), Postives = 109/126 (86.51%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTA 1228
            LNI+TV LNM+   FLGISIVGQSN+ GDGGIY+GSIMKGGAVA DGRIEPGDM+L+VN+I+FE+MSNDDAVR LRE V KPGPI L VAKCWDP+P+G FT+PR EP+RPIDP AWV HT AMT 
Sbjct:  245 LNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNEINFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPRGCFTLPRSEPIRPIDPAAWVSHTAAMTG 370          

HSP 2 Score: 164.081 bits (414), Expect = 3.125e-41
Identity = 73/134 (54.48%), Postives = 105/134 (78.36%), Query Frame = 2
Query: 1535 ESERYQEELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRLSLDQVESVSEVGVNGPHHLAALPPP 1936
            ++ER  ++ HL+ ++D+  I++ ++ P+SGL++RDR+WLKIT+PNAFIGS++VDWLY ++EGF+DR+EARKYA+NLLK G+I+HTVNK+TFSEQCYY+ G+   NM+ LSL   +  S  G +    LA LP P
Sbjct:  397 DTERL-DDFHLSIHSDMAAIVKAMASPESGLEVRDRMWLKITIPNAFIGSDVVDWLYHNVEGFTDRREARKYASNLLKAGFIRHTVNKITFSEQCYYIFGDLCGNMANLSLHDHDGSS--GASDQDTLAPLPHP 527          

HSP 3 Score: 136.346 bits (342), Expect = 2.286e-32
Identity = 59/82 (71.95%), Postives = 70/82 (85.37%), Query Frame = 2
Query:  104 ETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALNRPHYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGS 349
            ET+IIYH+D +ETPYL+KL +  ++VTL D K  L RP YK+FFKSMDDDFGVVKEEI+DD AKLPCF GRV+SWLV+AEGS
Sbjct:    3 ETKIIYHLDGQETPYLVKLPLPAERVTLADFKGVLQRPSYKFFFKSMDDDFGVVKEEISDDNAKLPCFNGRVVSWLVSAEGS 84          
BLAST of Dvl-2 vs. Ensembl Mouse
Match: Dvl2 (dishevelled segment polarity protein 2 [Source:MGI Symbol;Acc:MGI:106613])

HSP 1 Score: 206.068 bits (523), Expect = 4.807e-55
Identity = 94/134 (70.15%), Postives = 111/134 (82.84%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTAGASEPPSS 1252
            LNI+TV LNM+   FLGISIVGQSN+ GDGGIY+GSIMKGGAVA DGRIEPGDM+L+VND++FE+MSNDDAVR LR+ V KPGPI L VAKCWDP+P+ YFT+PR EP++PIDP AWV H+ A+T      P S
Sbjct:  263 LNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDMNFENMSNDDAVRVLRDIVHKPGPIVLTVAKCWDPSPQAYFTLPRNEPIQPIDPAAWVSHSAALTGAFPAYPGS 396          

HSP 2 Score: 149.058 bits (375), Expect = 2.401e-36
Identity = 63/111 (56.76%), Postives = 89/111 (80.18%), Query Frame = 2
Query: 1505 SIVTTSSSLPESERYQEELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGN 1837
            S +T+ SSLP+     E   L+ + D+ ++ + ++ P+SGL++RDR+WLKIT+PNAF+GS++VDWLY H+EGF +R+EARKYA+ LLK G I+HTVNK+TFSEQCYYV G+
Sbjct:  400 STITSGSSLPDG---CEGRGLSVHMDMASVTKAMAAPESGLEVRDRMWLKITIPNAFLGSDVVDWLYHHVEGFPERREARKYASGLLKAGLIRHTVNKITFSEQCYYVFGD 507          

HSP 3 Score: 126.331 bits (316), Expect = 3.992e-29
Identity = 53/81 (65.43%), Postives = 69/81 (85.19%), Query Frame = 2
Query:  104 ETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALNRPH-YKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAE 343
            ET++IYH+DEEETPYL+K+ +  +++TLGD K+ L RP   KYFFKSMD DFGVVKEEI+DD A+LPCF GRV+SWLV+++
Sbjct:   13 ETKVIYHLDEEETPYLVKIPVPAERITLGDFKSVLQRPAGAKYFFKSMDQDFGVVKEEISDDNARLPCFNGRVVSWLVSSD 93          
BLAST of Dvl-2 vs. Ensembl Mouse
Match: Dvl2 (dishevelled segment polarity protein 2 [Source:MGI Symbol;Acc:MGI:106613])

HSP 1 Score: 206.068 bits (523), Expect = 4.807e-55
Identity = 94/134 (70.15%), Postives = 111/134 (82.84%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTAGASEPPSS 1252
            LNI+TV LNM+   FLGISIVGQSN+ GDGGIY+GSIMKGGAVA DGRIEPGDM+L+VND++FE+MSNDDAVR LR+ V KPGPI L VAKCWDP+P+ YFT+PR EP++PIDP AWV H+ A+T      P S
Sbjct:  263 LNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDMNFENMSNDDAVRVLRDIVHKPGPIVLTVAKCWDPSPQAYFTLPRNEPIQPIDPAAWVSHSAALTGAFPAYPGS 396          

HSP 2 Score: 149.058 bits (375), Expect = 2.401e-36
Identity = 63/111 (56.76%), Postives = 89/111 (80.18%), Query Frame = 2
Query: 1505 SIVTTSSSLPESERYQEELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGN 1837
            S +T+ SSLP+     E   L+ + D+ ++ + ++ P+SGL++RDR+WLKIT+PNAF+GS++VDWLY H+EGF +R+EARKYA+ LLK G I+HTVNK+TFSEQCYYV G+
Sbjct:  400 STITSGSSLPDG---CEGRGLSVHMDMASVTKAMAAPESGLEVRDRMWLKITIPNAFLGSDVVDWLYHHVEGFPERREARKYASGLLKAGLIRHTVNKITFSEQCYYVFGD 507          

HSP 3 Score: 126.331 bits (316), Expect = 3.992e-29
Identity = 53/81 (65.43%), Postives = 69/81 (85.19%), Query Frame = 2
Query:  104 ETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALNRPH-YKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAE 343
            ET++IYH+DEEETPYL+K+ +  +++TLGD K+ L RP   KYFFKSMD DFGVVKEEI+DD A+LPCF GRV+SWLV+++
Sbjct:   13 ETKVIYHLDEEETPYLVKIPVPAERITLGDFKSVLQRPAGAKYFFKSMDQDFGVVKEEISDDNARLPCFNGRVVSWLVSSD 93          
BLAST of Dvl-2 vs. Ensembl Mouse
Match: Dvl2 (dishevelled segment polarity protein 2 [Source:MGI Symbol;Acc:MGI:106613])

HSP 1 Score: 206.068 bits (523), Expect = 4.807e-55
Identity = 94/134 (70.15%), Postives = 111/134 (82.84%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTAGASEPPSS 1252
            LNI+TV LNM+   FLGISIVGQSN+ GDGGIY+GSIMKGGAVA DGRIEPGDM+L+VND++FE+MSNDDAVR LR+ V KPGPI L VAKCWDP+P+ YFT+PR EP++PIDP AWV H+ A+T      P S
Sbjct:  263 LNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDMNFENMSNDDAVRVLRDIVHKPGPIVLTVAKCWDPSPQAYFTLPRNEPIQPIDPAAWVSHSAALTGAFPAYPGS 396          

HSP 2 Score: 149.058 bits (375), Expect = 2.401e-36
Identity = 63/111 (56.76%), Postives = 89/111 (80.18%), Query Frame = 2
Query: 1505 SIVTTSSSLPESERYQEELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGN 1837
            S +T+ SSLP+     E   L+ + D+ ++ + ++ P+SGL++RDR+WLKIT+PNAF+GS++VDWLY H+EGF +R+EARKYA+ LLK G I+HTVNK+TFSEQCYYV G+
Sbjct:  400 STITSGSSLPDG---CEGRGLSVHMDMASVTKAMAAPESGLEVRDRMWLKITIPNAFLGSDVVDWLYHHVEGFPERREARKYASGLLKAGLIRHTVNKITFSEQCYYVFGD 507          

HSP 3 Score: 126.331 bits (316), Expect = 3.992e-29
Identity = 53/81 (65.43%), Postives = 69/81 (85.19%), Query Frame = 2
Query:  104 ETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALNRPH-YKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAE 343
            ET++IYH+DEEETPYL+K+ +  +++TLGD K+ L RP   KYFFKSMD DFGVVKEEI+DD A+LPCF GRV+SWLV+++
Sbjct:   13 ETKVIYHLDEEETPYLVKIPVPAERITLGDFKSVLQRPAGAKYFFKSMDQDFGVVKEEISDDNARLPCFNGRVVSWLVSSD 93          
BLAST of Dvl-2 vs. UniProt/SwissProt
Match: sp|P51140|DSH_DROME (Segment polarity protein dishevelled OS=Drosophila melanogaster OX=7227 GN=dsh PE=1 SV=2)

HSP 1 Score: 226.868 bits (577), Expect = 5.089e-62
Identity = 104/129 (80.62%), Postives = 116/129 (89.92%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTAGAS 1237
            LNI+TV +NM+ V FLGISIVGQSN+GGDGGIYVGSIMKGGAVA DGRIEPGDMIL+VND++FE+M+ND+AVR LRE VQKPGPI LVVAKCWDPNPKGYFTIPR EPVRPIDP AWV HT A+T+  S
Sbjct:  248 LNIITVSINMEAVNFLGISIVGQSNRGGDGGIYVGSIMKGGAVALDGRIEPGDMILQVNDVNFENMTNDEAVRVLREVVQKPGPIKLVVAKCWDPNPKGYFTIPRTEPVRPIDPGAWVAHTQALTSHDS 376          

HSP 2 Score: 122.479 bits (306), Expect = 2.692e-27
Identity = 57/89 (64.04%), Postives = 69/89 (77.53%), Query Frame = 2
Query:  104 ETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALNRPH--YKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGSTVSDN 364
            ET++IYHID+E TPYL+K+ I   +VTL D K  LN+ +  YKYFFKSMD DFGVVKEEI DD   LPCF GRV+SWLV+A+G+  SDN
Sbjct:   10 ETKVIYHIDDETTPYLVKIPIPSAQVTLRDFKLVLNKQNNNYKYFFKSMDADFGVVKEEIADDSTILPCFNGRVVSWLVSADGTNQSDN 98          

HSP 3 Score: 119.013 bits (297), Expect = 3.239e-26
Identity = 47/80 (58.75%), Postives = 68/80 (85.00%), Query Frame = 2
Query: 1592 ILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVL 1831
            I++ +++PDSGL+IRDR+WLKIT+PNAFIG++ V+W+  ++E   DR+EAR+  + +L+  YIKHTVNK+TFSEQCYYV+
Sbjct:  397 IVKAMTKPDSGLEIRDRMWLKITIPNAFIGADAVNWVLENVEDVQDRREARRIVSAMLRSNYIKHTVNKLTFSEQCYYVV 476          
BLAST of Dvl-2 vs. UniProt/SwissProt
Match: sp|Q61062|DVL3_MOUSE (Segment polarity protein dishevelled homolog DVL-3 OS=Mus musculus OX=10090 GN=Dvl3 PE=1 SV=2)

HSP 1 Score: 210.69 bits (535), Expect = 7.165e-56
Identity = 96/126 (76.19%), Postives = 109/126 (86.51%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTA 1228
            LNI+TV LNM+   FLGISIVGQSN+ GDGGIY+GSIMKGGAVA DGRIEPGDM+L+VN+I+FE+MSNDDAVR LRE V KPGPI L VAKCWDP+P+G FT+PR EP+RPIDP AWV HT AMT 
Sbjct:  245 LNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNEINFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPRGCFTLPRSEPIRPIDPAAWVSHTAAMTG 370          

HSP 2 Score: 164.081 bits (414), Expect = 2.186e-40
Identity = 73/134 (54.48%), Postives = 105/134 (78.36%), Query Frame = 2
Query: 1535 ESERYQEELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRLSLDQVESVSEVGVNGPHHLAALPPP 1936
            ++ER  ++ HL+ ++D+  I++ ++ P+SGL++RDR+WLKIT+PNAFIGS++VDWLY ++EGF+DR+EARKYA+NLLK G+I+HTVNK+TFSEQCYY+ G+   NM+ LSL   +  S  G +    LA LP P
Sbjct:  397 DTERL-DDFHLSIHSDMAAIVKAMASPESGLEVRDRMWLKITIPNAFIGSDVVDWLYHNVEGFTDRREARKYASNLLKAGFIRHTVNKITFSEQCYYIFGDLCGNMANLSLHDHDGSS--GASDQDTLAPLPHP 527          

HSP 3 Score: 136.346 bits (342), Expect = 1.599e-31
Identity = 59/82 (71.95%), Postives = 70/82 (85.37%), Query Frame = 2
Query:  104 ETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALNRPHYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGS 349
            ET+IIYH+D +ETPYL+KL +  ++VTL D K  L RP YK+FFKSMDDDFGVVKEEI+DD AKLPCF GRV+SWLV+AEGS
Sbjct:    3 ETKIIYHLDGQETPYLVKLPLPAERVTLADFKGVLQRPSYKFFFKSMDDDFGVVKEEISDDNAKLPCFNGRVVSWLVSAEGS 84          
BLAST of Dvl-2 vs. UniProt/SwissProt
Match: sp|Q92997|DVL3_HUMAN (Segment polarity protein dishevelled homolog DVL-3 OS=Homo sapiens OX=9606 GN=DVL3 PE=1 SV=2)

HSP 1 Score: 210.69 bits (535), Expect = 8.246e-56
Identity = 96/126 (76.19%), Postives = 109/126 (86.51%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTA 1228
            LNI+TV LNM+   FLGISIVGQSN+ GDGGIY+GSIMKGGAVA DGRIEPGDM+L+VN+I+FE+MSNDDAVR LRE V KPGPI L VAKCWDP+P+G FT+PR EP+RPIDP AWV HT AMT 
Sbjct:  245 LNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNEINFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPRGCFTLPRSEPIRPIDPAAWVSHTAAMTG 370          

HSP 2 Score: 163.696 bits (413), Expect = 2.349e-40
Identity = 73/134 (54.48%), Postives = 105/134 (78.36%), Query Frame = 2
Query: 1535 ESERYQEELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRLSLDQVESVSEVGVNGPHHLAALPPP 1936
            ++ER  ++ HL+ ++D+  I++ ++ P+SGL++RDR+WLKIT+PNAFIGS++VDWLY ++EGF+DR+EARKYA+NLLK G+I+HTVNK+TFSEQCYY+ G+   NM+ LSL   +  S  G +    LA LP P
Sbjct:  397 DTERL-DDFHLSIHSDMAAIVKAMASPESGLEVRDRMWLKITIPNAFIGSDVVDWLYHNVEGFTDRREARKYASNLLKAGFIRHTVNKITFSEQCYYIFGDLCGNMANLSLHDHDGSS--GASDQDTLAPLPHP 527          

HSP 3 Score: 136.346 bits (342), Expect = 1.731e-31
Identity = 59/82 (71.95%), Postives = 70/82 (85.37%), Query Frame = 2
Query:  104 ETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALNRPHYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGS 349
            ET+IIYH+D +ETPYL+KL +  ++VTL D K  L RP YK+FFKSMDDDFGVVKEEI+DD AKLPCF GRV+SWLV+AEGS
Sbjct:    3 ETKIIYHLDGQETPYLVKLPLPAERVTLADFKGVLQRPSYKFFFKSMDDDFGVVKEEISDDNAKLPCFNGRVVSWLVSAEGS 84          
BLAST of Dvl-2 vs. UniProt/SwissProt
Match: sp|B1WAP7|DVL3_XENTR (Segment polarity protein dishevelled homolog DVL-3 OS=Xenopus tropicalis OX=8364 GN=dvl3 PE=2 SV=1)

HSP 1 Score: 208.379 bits (529), Expect = 4.102e-55
Identity = 95/126 (75.40%), Postives = 107/126 (84.92%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTA 1228
            LNI+TV LNM+   FLGISIVGQSN+ GDGGIY+GSIMKGGAVA DGRIEPGDM+L+VND +FE+MSNDDAVR LRE V KPGPI L VAKCWDP+P+  FT+PR EP+RPIDP AWV HT AMT 
Sbjct:  244 LNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDTNFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPRNCFTLPRSEPIRPIDPAAWVSHTAAMTG 369          

HSP 2 Score: 169.474 bits (428), Expect = 3.727e-42
Identity = 76/134 (56.72%), Postives = 106/134 (79.10%), Query Frame = 2
Query: 1535 ESERYQEELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRLSLDQVESVSEVGVNGPHHLAALPPP 1936
            E+ER+ ++  L+ ++D+ TI++ +  P+SGL++RDR+WLKIT+PNAFIGS++VDWLY H+EGF+DR+EARKYA+NLLK GYI+HTVNK+TFSEQCYY+ G+   NM+ LSL+  +  S  G +    LA LP P
Sbjct:  396 ETERF-DDFQLSIHSDMVTIVKAMRSPESGLEVRDRMWLKITIPNAFIGSDVVDWLYHHVEGFTDRREARKYASNLLKAGYIRHTVNKITFSEQCYYIFGDLCGNMANLSLNDHDGSS--GTSDQDTLAPLPHP 526          

HSP 3 Score: 144.436 bits (363), Expect = 4.801e-34
Identity = 64/103 (62.14%), Postives = 82/103 (79.61%), Query Frame = 2
Query:  104 ETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALNRPHYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGSTVSDNVDSNGILDKNESRMLP 412
            ET++IYH+DE+ETPYL+KL +  +KVTLGD KN LN+P+YK+FFKSMDDDFGVVKEEI+DD AKLPCF GRV+ WLV+A+GS      D+  +   N+S + P
Sbjct:    3 ETKVIYHLDEQETPYLVKLPVPAEKVTLGDFKNVLNKPNYKFFFKSMDDDFGVVKEEISDDNAKLPCFNGRVVCWLVSADGS----QSDAGSVCADNQSDLPP 101          
BLAST of Dvl-2 vs. UniProt/SwissProt
Match: sp|Q05AS8|DVL2_XENTR (Segment polarity protein dishevelled homolog DVL-2 OS=Xenopus tropicalis OX=8364 GN=dvl2 PE=2 SV=1)

HSP 1 Score: 208.379 bits (529), Expect = 5.093e-55
Identity = 93/126 (73.81%), Postives = 110/126 (87.30%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTA 1228
            LNI+TV LNM+   FLGISIVGQSN+ GDGGIY+GSIMKGGAVA DGRIEPGDM+L+VNDI+FE+MSNDDAVR LR+ V KPGPI L VAKCWDP+P+GYFT+PR EP++PIDP AWV H+ A++ 
Sbjct:  246 LNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDINFENMSNDDAVRVLRDIVHKPGPIILTVAKCWDPSPQGYFTLPRNEPIQPIDPAAWVSHSAALSG 371          

HSP 2 Score: 155.221 bits (391), Expect = 1.714e-37
Identity = 71/130 (54.62%), Postives = 99/130 (76.15%), Query Frame = 2
Query: 1565 LTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTL---NMSRLSLDQVESVSEVGVNGPHHLAALPPPNFS 1945
            L+ +TD+ ++ +V++ P+SGL++RDR+WLKIT+PNAF+GS++VDWLY H+EGF DR+EARK+A+NLLK G I+HTVNK+TFSEQCYY+ G+ T     M+ LSL+  +  S  G +    LA LP P  S
Sbjct:  408 LSVHTDLASVAKVMASPESGLEVRDRMWLKITIPNAFLGSDMVDWLYHHVEGFQDRREARKFASNLLKAGLIRHTVNKITFSEQCYYIFGDLTGCENYMANLSLNDNDGSS--GASDQDTLAPLPLPGAS 535          

HSP 3 Score: 127.102 bits (318), Expect = 1.454e-28
Identity = 54/82 (65.85%), Postives = 68/82 (82.93%), Query Frame = 2
Query:  104 ETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALNRPHYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGS 349
            ET++IYH+DEEETPYL+K+ +  +++ L D K AL R H KYFFK+MD DFGVVKEEI+DD AKLPCF GRV+SWLV++E S
Sbjct:    3 ETKVIYHLDEEETPYLVKVPVPANEIRLRDFKAALGRGHAKYFFKAMDQDFGVVKEEISDDNAKLPCFNGRVVSWLVSSETS 84          
BLAST of Dvl-2 vs. TrEMBL
Match: F2WMR5 (Dvl-2 OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 1229.16 bits (3179), Expect = 0.000e+0
Identity = 773/775 (99.74%), Postives = 773/775 (99.74%), Query Frame = 2
Query:   65 MTNCATSGNVISDETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALNRPHYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGSTVSDNVDSNGILDKNESRMLPFQESHFPLINNIKASGGTTTNESXXXXXXXXXXXSVYSAAQDRVGPLRSFHDYKQAGRVAAHANRVNTNTPNGQNPIYETNXXXXXXXXXXXXXXXXXXXXXXXXXXTCTTMXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTAGASEPPSSVNGVHPQVSNLVAPSMQSLLSGGTMLXXXXXXXXXXXXXXYMPQPQNINQNTASVSTVGGPPGASVGFFGYPMGMPGQFSQGAGSIVTTSSSLPESERYQEELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRLSLDQVESVSEVGVNGPHHLAALPPPNFSSNKQPISSCINQPPLNINPQLTATSEPLPXXXXXXXXXXXXXXXQYSVVGPLPCXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXASSVSNMISKNPPPKIPPRTIASVSTNSTNPIISGFQNRGQSSVSQ 2389
            MTNCATSGNVISDETRIIYHIDEEETPYLIKLSISPDKVTLGDLKN LNRPHYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGSTVSDNVDSNGILDKNESRMLPFQESHFPLINNIKASGGTTTNESDTICDTCTDTDSVYSAAQDRVGP RSFHDYKQAGRVAAHANRVNTNTPNGQNPIYETNSSMMSSDLESTSFFDSEDESSRFSTTTCTTMSSRYGRQKQQRRRRRPPAISRASSFSSITDSTMSLNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTAGASEPPSSVNGVHPQVSNLVAPSMQSLLSGGTMLAGTSAATFNAAAFGYMPQPQNINQNTASVSTVGGPPGASVGFFGYPMGMPGQFSQGAGSIVTTSSSLPESERYQEELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRLSLDQVESVSEVGVNGPHHLAALPPPNFSSNKQPISSCINQPPLNINPQLTATSEPLPSNNANVATATASSNSQYSVVGPLPCSQPSQHASSNASASAIKKSGSCNSLSGSSSSTSSSSSSNRSNTRINGNASSVSNMISKNPPPKIPPRTIASVSTNSTNPIISGFQNRGQSSVSQ
Sbjct:    1 MTNCATSGNVISDETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNTLNRPHYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGSTVSDNVDSNGILDKNESRMLPFQESHFPLINNIKASGGTTTNESDTICDTCTDTDSVYSAAQDRVGPPRSFHDYKQAGRVAAHANRVNTNTPNGQNPIYETNSSMMSSDLESTSFFDSEDESSRFSTTTCTTMSSRYGRQKQQRRRRRPPAISRASSFSSITDSTMSLNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTAGASEPPSSVNGVHPQVSNLVAPSMQSLLSGGTMLAGTSAATFNAAAFGYMPQPQNINQNTASVSTVGGPPGASVGFFGYPMGMPGQFSQGAGSIVTTSSSLPESERYQEELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRLSLDQVESVSEVGVNGPHHLAALPPPNFSSNKQPISSCINQPPLNINPQLTATSEPLPSNNANVATATASSNSQYSVVGPLPCSQPSQHASSNASASAIKKSGSCNSLSGSSSSTSSSSSSNRSNTRINGNASSVSNMISKNPPPKIPPRTIASVSTNSTNPIISGFQNRGQSSVSQ 775          
BLAST of Dvl-2 vs. TrEMBL
Match: B1NWV9 (Dishevelled-like protein (Fragment) OS=Schmidtea mediterranea OX=79327 GN=Dvl-b PE=2 SV=1)

HSP 1 Score: 913.294 bits (2359), Expect = 0.000e+0
Identity = 543/545 (99.63%), Postives = 543/545 (99.63%), Query Frame = 2
Query:  170 PDKVTLGDLKNALNRPHYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGSTVSDNVDSNGILDKNESRMLPFQESHFPLINNIKASGGTTTNESXXXXXXXXXXXSVYSAAQDRVGPLRSFHDYKQAGRVAAHANRVNTNTPNGQNPIYETNXXXXXXXXXXXXXXXXXXXXXXXXXXTCTTMXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTAGASEPPSSVNGVHPQVSNLVAPSMQSLLSGGTMLXXXXXXXXXXXXXXYMPQPQNINQNTASVSTVGGPPGASVGFFGYPMGMPGQFSQGAGSIVTTSSSLPESERYQEELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVT 1804
            PDKVTLGDLKN LNRPHYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGSTVSDNVDSNGILDKNESRMLPFQESHFPLINNIKASGGTTTNESDTICDTCTDTDSVYSAAQDRVGP RSFHDYKQAGRVAAHANRVNTNTPNGQNPIYETNSSMMSSDLESTSFFDSEDESSRFSTTTCTTMSSRYGRQKQQRRRRRPPAISRASSFSSITDSTMSLNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTAGASEPPSSVNGVHPQVSNLVAPSMQSLLSGGTMLAGTSAATFNAAAFGYMPQPQNINQNTASVSTVGGPPGASVGFFGYPMGMPGQFSQGAGSIVTTSSSLPESERYQEELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVT
Sbjct:    1 PDKVTLGDLKNTLNRPHYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGSTVSDNVDSNGILDKNESRMLPFQESHFPLINNIKASGGTTTNESDTICDTCTDTDSVYSAAQDRVGPPRSFHDYKQAGRVAAHANRVNTNTPNGQNPIYETNSSMMSSDLESTSFFDSEDESSRFSTTTCTTMSSRYGRQKQQRRRRRPPAISRASSFSSITDSTMSLNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTAGASEPPSSVNGVHPQVSNLVAPSMQSLLSGGTMLAGTSAATFNAAAFGYMPQPQNINQNTASVSTVGGPPGASVGFFGYPMGMPGQFSQGAGSIVTTSSSLPESERYQEELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVT 545          
BLAST of Dvl-2 vs. TrEMBL
Match: D3J1K0 (Dishevelled (Fragment) OS=Schmidtea polychroa OX=50054 GN=dvl PE=2 SV=1)

HSP 1 Score: 628.246 bits (1619), Expect = 0.000e+0
Identity = 317/318 (99.69%), Postives = 317/318 (99.69%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTAGASEPPSSVNGVHPQVSNLVAPSMQSLLSGGTMLXXXXXXXXXXXXXXYMPQPQNINQNTASVSTVGGPPGASVGFFGYPMGMPGQFSQGAGSIVTTSSSLPESERYQEELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVT 1804
            LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTAGASEPPSSVNGVHPQVSNLVAPSMQSLLSGGTMLAGTSAATFNAAAFGYMPQPQNINQNTASVSTVGGPPG SVGFFGYPMGMPGQFSQGAGSIVTTSSSLPESERYQEELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVT
Sbjct:  216 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTAGASEPPSSVNGVHPQVSNLVAPSMQSLLSGGTMLAGTSAATFNAAAFGYMPQPQNINQNTASVSTVGGPPGTSVGFFGYPMGMPGQFSQGAGSIVTTSSSLPESERYQEELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVT 533          

HSP 2 Score: 308.145 bits (788), Expect = 9.140e-90
Identity = 159/162 (98.15%), Postives = 159/162 (98.15%), Query Frame = 2
Query:  170 PDKVTLGDLKNALNRPHYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGSTVSDNVDSNGILDKNESRMLPFQESHFPLINNIKASGGTTTNESXXXXXXXXXXXSVYSAAQDRVGPLRSFHDYKQAGRVAAHANRVNTNTPNGQNPIYETN 655
            PDKVTLGDLKNALNRPHYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGSTVSDN DSNGILDKNESRMLPFQESHFPL NNIKASGGTTTNESDTICDTCTDTDSVYSAAQDRVGPLRSFHDYKQAGRVAAHANRVNTNTPNG NPIYETN
Sbjct:    1 PDKVTLGDLKNALNRPHYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGSTVSDNADSNGILDKNESRMLPFQESHFPLTNNIKASGGTTTNESDTICDTCTDTDSVYSAAQDRVGPLRSFHDYKQAGRVAAHANRVNTNTPNGPNPIYETN 162          
BLAST of Dvl-2 vs. TrEMBL
Match: A0A4Z2DKF8 (Putative Dishevelled segment polarity protein DVL-3 OS=Schistosoma japonicum OX=6182 GN=EWB00_000072 PE=4 SV=1)

HSP 1 Score: 535.798 bits (1379), Expect = 1.289e-170
Identity = 355/670 (52.99%), Postives = 422/670 (62.99%), Query Frame = 2
Query:   89 NVISDETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALNRPHYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGSTVSD---------------------NVDSNGILDKNESR----MLPFQESHFPLINNIKASGGTTTNESXXXXXXXXXXXSVYSAAQDRVGPLRSF--------HDYKQAG--RVAAHANRVNTNTPN----GQNPIYETNXXXXXXXXXXXXXXXXXXXXXXXXXXTCTTMXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNP-KGYFTIPRQEPVRPIDPRAWVLHTNAMT-----AGASEPPSSVNG--------------------VHPQVSNLVAPSMQSLLSGGTMLXXXXXXXXXXXXXXYMPQPQNINQNTASVSTVGGPPGASVGFFGYPMGMPGQFSQGAGSIVTTSSSLPESERYQEELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRLSLDQVESVSEVGVN 1903
            N    ET+ IY+IDEEETPYL+KL+I+P+KVTLGD KNALNRPH K+FFKS+DDDFGVVKEEI +D A LPCF GRVISWLVTAE S  SD                     N+D      +NE +    +L    +  P  ++  A+ G   N             SV+SA QDR+ PLR+F        H Y   G   +   AN  N+   +      +  YET S M S    ++     E+ S   S T  T  S RY R +++RRRRRPP ISRASSFSSITDSTMSLNIV+V LNMDTV FLGISIVGQSNK GDGGIYVGSIMKGGAVAQDGRIEPGDMILE N ISFE+MSNDDAVRTLREQVQ+PGPI LVVAKCWDPNP + YFTIPRQEPV PIDPRAWVLHTNAMT     A   +P   VNG                    + P +S     S Q+ +  GT  A  + A   AA+     Q             +  P   S      P G   Q    A SIVT SSSLPE ERY + + L+ +T + T++R + QPDSGLDIRDR+WLK+T+PNAFIGS+LVDWL+RH+EG +DR+EARKYA+NLLK GYI+H VNK+TFSEQCYYV  + +  MS LSL++V+SVSEVG +
Sbjct:    5 NSFVGETKFIYYIDEEETPYLVKLNIAPEKVTLGDFKNALNRPHSKFFFKSLDDDFGVVKEEIFEDNAPLPCFNGRVISWLVTAEESIASDPGVLSPSIETNTNANNNKYPPNLDLESSNTRNECKGSSCVLQPHTTAAP-ADSTSANLGHGRNTGQNYDTETE---SVHSANQDRIAPLRNFHHYKSSGRHHYTMGGSSHLVQQANHNNSRHRHYRHLASSSTYETPSMMSSDLESTSFLDSEEESSRFSSVTGTTLSSRRYSRARRRRRRRRPPPISRASSFSSITDSTMSLNIVSVTLNMDTVNFLGISIVGQSNKSGDGGIYVGSIMKGGAVAQDGRIEPGDMILEANGISFEEMSNDDAVRTLREQVQRPGPITLVVAKCWDPNPAERYFTIPRQEPVHPIDPRAWVLHTNAMTTPDSHAQGGDPHRHVNGASMTGASSGGESSSTLSPPGLTPGMSMGTLTSGQTSMPLGTSAAAFNMAALLAASKQKQEQELQQQNLLQQRIHLSQPTCYSASNMLLPHGYTQQI---APSIVTVSSSLPEIERYSDPIPLSLSTSIPTVIRAMLQPDSGLDIRDRVWLKLTVPNAFIGSDLVDWLFRHLEGLTDRREARKYASNLLKLGYIRHIVNKLTFSEQCYYVFRDISERMSCLSLEEVDSVSEVGAH 667          
BLAST of Dvl-2 vs. TrEMBL
Match: A0A5K4EAL9 (Putative dishevelled OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 528.48 bits (1360), Expect = 5.685e-169
Identity = 366/704 (51.99%), Postives = 445/704 (63.21%), Query Frame = 2
Query:  101 DETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALNRPHYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGSTVSDNVDSNGILDKNESRMLPFQESHFPLIN----NIKASGGT-----------TTNESXXXXXXXXXXXSVYSAAQDRVGPLRSFHDYKQAGRVAAHANRVNTNTPNGQNPIYETNXXXXXXXXXXXXXXXXXXXXXXXXXXTCTTMXXXXXXXXXXXXXXX-----XXXXXXXXXXXXXXXXXXXLNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTAGASEPPSSVNGVHPQVSNLVAPSMQSLLSGGTMLXXXXXXXXXXXXXXYMPQ---PQNI---------NQNTASVSTVGGPPG---------ASVGFFGYPMGMPGQFSQGAGSIVTTSS---SLPESERYQEELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRLSLDQVESVSEVGVNG--------------PHHLAALPPPNFSSNKQPISSCINQ--PPLNINPQLTATSEPLP 2032
            D+T+IIYHID+EETPYL+K+++ P+ VTLGD KNALNRP+YK+FFKS+D DFGVVKEEI DD+A+LPCF G+VISWLV+A+ ST SDN  S G  + +    LP Q  +    N    NI +               TT      CDTC +TDSVYS   DRV PL++FH+YK   R+A    R+       QN  YET+SSMMSSDLESTSFFDSEDESSRFST T TTMSS    + +++RR R           A+SFSS+TDSTMSLNI+TV LNMD+V FLGISIVGQSNK GDGGIYVGSIM+GGAVAQDGRIEPGDMILEVN ISFEDMSND+AVR LRE+VQKPGPI LVVAKCWDP+PK YFTIPRQEPVRPIDPRAWVLHTNAMT     P    +G  P   +    +  +++ G  M    S+     +    MP    P ++         N  T S+  V    G         AS G  G P       S+  G     +    SL      +    LT  +D+ +++  +   DSGL+IRDR WLKIT+PNAFIGS LVDWL+ H++GF+DR++AR+YA+NLL +GYI HTVNK TFSEQCYY  G+    +S L+LD+V+SVSE+G N               PH    LP    S +   +SS  NQ  PP   NP L   S P+P
Sbjct:    2 DDTKIIYHIDDEETPYLVKIAVCPNAVTLGDFKNALNRPNYKFFFKSVDADFGVVKEEIADDDARLPCFNGKVISWLVSADSSTKSDN-HSTGTGENH----LPGQNKNSTNFNKAPDNIHSVSKNEIPSEQEHAIGTTGHGLEECDTCVETDSVYSG--DRVPPLKNFHNYKHGSRLAKLGQRI-------QN--YETSSSMMSSDLESTSFFDSEDESSRFSTATGTTMSSAKYPRHRRQRRHRRILPIRRTSEDATSFSSVTDSTMSLNIITVTLNMDSVNFLGISIVGQSNKAGDGGIYVGSIMRGGAVAQDGRIEPGDMILEVNRISFEDMSNDEAVRVLREEVQKPGPITLVVAKCWDPSPKNYFTIPRQEPVRPIDPRAWVLHTNAMTGALGTP--GFDGNTPFFGSGSPAAGMAMIPGHFMGMTPSSGLSVPSMPPGMPPLILPPSMAGINAIPSSNMTTKSLPEVADGDGGGYHRSRGPASSGVVGGPGSTKTNGSRSGGETTVDAKGTQSLLSGANGKSSTSLTVASDMASVVHDMLMSDSGLEIRDRTWLKITIPNAFIGSELVDWLFTHVDGFADRRDARRYASNLLHYGYICHTVNKSTFSEQCYYTFGDIATTLSHLNLDEVDSVSEIGANSSSHTGTHPMMPQMYPHVHHVLPDAPGSGSATGLSSVQNQNAPP---NPNLGLMSSPIP 684          
BLAST of Dvl-2 vs. Ensembl Cavefish
Match: dvl2 (dishevelled segment polarity protein 2 [Source:NCBI gene;Acc:103045219])

HSP 1 Score: 214.157 bits (544), Expect = 1.011e-57
Identity = 96/126 (76.19%), Postives = 110/126 (87.30%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTA 1228
            LNI+TV LNM+   FLGISIVGQSN+ GDGGIY+GSIMKGGAVA DGRIEPGDM+L+VNDI+FE+MSNDDAVR LRE V KPGPI L VAKCWDP+P+GYFT+PR EP+RPIDP AWV H+ A+T 
Sbjct:  252 LNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDINFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPQGYFTLPRNEPIRPIDPAAWVSHSVALTG 377          

HSP 2 Score: 154.451 bits (389), Expect = 3.393e-38
Identity = 69/131 (52.67%), Postives = 101/131 (77.10%), Query Frame = 2
Query: 1553 EELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTL---NMSRLSLDQVESVSEVGVNGPHHLAALPPP 1936
            +E +L+ ++D+ ++ + ++ P+SGL++RDR+WLKIT+PNAF+GS++V+WLY HIEGF DR+EARKYA+NLLK G+I+HTVNK+TFSEQCYY+ G+ +     M+ LSL+  +  S  G +    LA LP P
Sbjct:  400 DEFNLSLHSDMASVAKAMASPESGLEVRDRMWLKITIPNAFLGSDVVEWLYHHIEGFQDRREARKYASNLLKAGFIRHTVNKITFSEQCYYIFGDFSDCENYMANLSLNDNDGSS--GASDQDTLAPLPLP 528          

HSP 3 Score: 134.035 bits (336), Expect = 1.270e-31
Identity = 57/80 (71.25%), Postives = 70/80 (87.50%), Query Frame = 2
Query:  104 ETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALNRPHYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAE 343
            ET+IIYHIDEEETPYL+K+ I  +K+TL D K  LN+P+YK+FFKSMD DFGVVKEEI+DD AKLPCF GRV+SWLV+++
Sbjct:    3 ETKIIYHIDEEETPYLVKIPIPAEKITLLDFKQVLNKPNYKFFFKSMDQDFGVVKEEISDDSAKLPCFNGRVVSWLVSSD 82          
BLAST of Dvl-2 vs. Ensembl Cavefish
Match: dvl1a (segment polarity protein dishevelled homolog DVL-1 [Source:NCBI gene;Acc:103035729])

HSP 1 Score: 213.772 bits (543), Expect = 1.041e-57
Identity = 96/126 (76.19%), Postives = 109/126 (86.51%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTA 1228
            LNI+TV LNM+   FLGISIVGQSN  GDGGIY+GSIMKGGAVA DGRIEPGDM+L+VND++FE+MSNDDAVR LRE V KPGPI+L VAKCWDP+P+ YFTIPR EPVRPIDP AW+ HT A+T 
Sbjct:  251 LNIITVTLNMEKYNFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRILREIVSKPGPISLTVAKCWDPSPRSYFTIPRAEPVRPIDPAAWISHTTALTG 376          

HSP 2 Score: 146.747 bits (369), Expect = 8.401e-36
Identity = 65/121 (53.72%), Postives = 90/121 (74.38%), Query Frame = 2
Query: 1574 NTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRLSLDQVESVSEVGVNGPHHLAALPPP 1936
             TD+ TI +V+  P+SGL+IRDR+WLKIT+ NA IG+++VDWL+  +EGF DR++ARKYA++LLK GY++HTVNK+TFSEQCYY  G+   NM+ L+L++  S           +A LPPP
Sbjct:  392 KTDMATIAKVMQLPESGLEIRDRMWLKITIANAVIGADVVDWLFSRVEGFKDRRDARKYASSLLKHGYLRHTVNKITFSEQCYYTFGDLCQNMASLNLNEGSSGGGGSEQDT--VAPLPPP 510          

HSP 3 Score: 136.732 bits (343), Expect = 1.593e-32
Identity = 66/89 (74.16%), Postives = 75/89 (84.27%), Query Frame = 2
Query:  104 ETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNAL-NRP--HYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGSTVSD 361
            ET+IIYH+DEEETPYL+KLS+SPD+VTL D K+ L NRP   YK+FFKSMD DFGVVKEEI+DD AKLPCF GRV+SWLV  E ST SD
Sbjct:    3 ETKIIYHVDEEETPYLVKLSVSPDRVTLADFKHVLSNRPTNSYKFFFKSMDQDFGVVKEEISDDNAKLPCFNGRVVSWLVLTE-STHSD 90          
BLAST of Dvl-2 vs. Ensembl Cavefish
Match: dvl1b (segment polarity protein dishevelled homolog DVL-1-like [Source:NCBI gene;Acc:103046093])

HSP 1 Score: 209.92 bits (533), Expect = 1.750e-56
Identity = 95/126 (75.40%), Postives = 108/126 (85.71%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTA 1228
            LNI+TV LNM+   FLGISIVGQSN  GDGGIY+GSIMKGGAVA DGRIEPGDM+L+VND++FE+MSNDDAVR LRE V K GPI+L VAKCWDP+P+ YFTIPR EPVRPIDP AW+ HT A+T 
Sbjct:  247 LNIITVTLNMEKYNFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRILREIVSKTGPISLTVAKCWDPSPRSYFTIPRAEPVRPIDPAAWISHTTALTG 372          

HSP 2 Score: 149.058 bits (375), Expect = 1.869e-36
Identity = 79/172 (45.93%), Postives = 113/172 (65.70%), Query Frame = 2
Query: 1454 FFGYPMGMPGQFSQGAGSIVTTSSSLPESERYQ-EELHLT-KNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRLSLDQVESVSEVGVNGPHHLAALPPPNFSSNKQPI 1963
            +F  P   P +    A  I  T++      +Y+ ++L LT   TD+ T+++V+  PDSGL+IRDR+WLKIT+ NA IG ++VDWLY  +EGF DR++ARKYA+ +LK GY++HTVNK+TFSEQCYY  G+   NM+ L+L++    S  G +    LA LPP   S+N  P+
Sbjct:  346 YFTIPRAEPVRPIDPAAWISHTTALTGSYPQYEFDDLPLTVGKTDMATLVKVMQLPDSGLEIRDRMWLKITIANAVIGGDVVDWLYSRVEGFKDRRDARKYASTMLKHGYLRHTVNKITFSEQCYYTFGDICQNMASLNLNE---GSSGGGSEQDTLAPLPP---STNPWPM 511          

HSP 3 Score: 138.658 bits (348), Expect = 3.969e-33
Identity = 65/85 (76.47%), Postives = 72/85 (84.71%), Query Frame = 2
Query:  104 ETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALN-RP--HYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGS 349
            ET+IIYHIDEEETPYL+KL ++PDKVTL D KN LN RP   YK+FFKSMD DFGVVKEEI+DD AKLPCF GRV+SWLV AE S
Sbjct:    3 ETKIIYHIDEEETPYLVKLPVAPDKVTLADFKNVLNNRPVNSYKFFFKSMDQDFGVVKEEISDDNAKLPCFNGRVVSWLVLAESS 87          
BLAST of Dvl-2 vs. Ensembl Cavefish
Match: dvl3a (segment polarity protein dishevelled homolog DVL-3-like [Source:NCBI gene;Acc:103042896])

HSP 1 Score: 206.453 bits (524), Expect = 1.228e-55
Identity = 93/126 (73.81%), Postives = 106/126 (84.13%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTA 1228
            LNI+TV LNM+   FLGISIVGQSN+ GDGGIY+GSIMKGGAVA DGRIEPGDM+L+VNDI+FE+M NDDAVR LR+ V KPGP++L VAKCWDPNP   F +PR EP+RPIDP AWV HT AMT 
Sbjct:  246 LNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDINFENMCNDDAVRVLRDIVHKPGPVSLTVAKCWDPNPNSCFALPRSEPIRPIDPAAWVSHTAAMTG 371          

HSP 2 Score: 170.244 bits (430), Expect = 1.434e-43
Identity = 76/136 (55.88%), Postives = 109/136 (80.15%), Query Frame = 2
Query: 1466 PMGMPGQFSQGAGSIVTTSSSLPESERYQEELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRLSLDQ 1873
            P GM    S    +  + SSS+PE+ER+ ++ HL+ ++D+ T+ + ++ PDSGL++RDR+WLKIT+ NAFIGS++VDWL+ H+EGF+DR+EARKYA+NLLK G+I+HTVNK+TFSEQCYYV G+ + NM+ LSL +
Sbjct:  375 PYGMSPSMSTVTSTSSSISSSIPETERF-DDYHLSVHSDMATVAKAMACPDSGLEVRDRMWLKITIANAFIGSDVVDWLFHHVEGFADRREARKYASNLLKAGFIRHTVNKITFSEQCYYVFGDLSGNMAHLSLHE 509          

HSP 3 Score: 139.813 bits (351), Expect = 1.058e-33
Identity = 58/82 (70.73%), Postives = 75/82 (91.46%), Query Frame = 2
Query:  104 ETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALNRPHYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGS 349
            ET++IYH+DE+ETPYL+KL++  ++VTL DLKNAL +P++K+FFKSMDDDFGVVKEEITDD AKLPC+ GRV+ WLV+A+GS
Sbjct:    3 ETKVIYHLDEQETPYLVKLAVPAERVTLSDLKNALKKPNHKFFFKSMDDDFGVVKEEITDDNAKLPCYNGRVVCWLVSADGS 84          
BLAST of Dvl-2 vs. Ensembl Cavefish
Match: dvl3b (dishevelled segment polarity protein 3b [Source:ZFIN;Acc:ZDB-GENE-121101-2])

HSP 1 Score: 196.438 bits (498), Expect = 2.515e-52
Identity = 89/113 (78.76%), Postives = 98/113 (86.73%), Query Frame = 2
Query:  893 FLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTAG 1231
             LGISIVGQSN+ GDGGIY+GSIMKGGAVA DGRIEPGDM+L+VNDI+FE+MSNDDAVR LRE V KPGPI L VAKCWDPNP+G FT+PR EP+RPIDP AWV HT AMT  
Sbjct:  240 LLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDINFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPNPRGCFTLPRSEPIRPIDPAAWVSHTAAMTGA 352          

HSP 2 Score: 173.326 bits (438), Expect = 1.083e-44
Identity = 77/134 (57.46%), Postives = 106/134 (79.10%), Query Frame = 2
Query: 1535 ESERYQEELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRLSLDQVESVSEVGVNGPHHLAALPPP 1936
            E+ER+ EE HL+ ++D+ TI + ++ P+SGL++RDR+WLKIT+PNAFIGS++VDWL+ H+EGF+DR+EARKYA+NLLK GYI+HTVNK+TFSEQCYY+ G+   NM+ L+L   +  S  G +    LA LP P
Sbjct:  378 ETERF-EEFHLSIHSDMATIAKAMASPESGLEVRDRMWLKITIPNAFIGSDVVDWLFHHVEGFTDRREARKYASNLLKAGYIRHTVNKITFSEQCYYIFGDLCGNMANLTLHDHDGSS--GASDQDTLAPLPHP 508          

HSP 3 Score: 142.124 bits (357), Expect = 1.728e-34
Identity = 63/98 (64.29%), Postives = 80/98 (81.63%), Query Frame = 2
Query:  104 ETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALNRPHYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGSTVSDNVDSNGILDKNE 397
            ET+IIYH+D++ETPYL+KL I  ++VTL D K+ LN+P+YK+FFKSMDDDFGVVKEEI+DD AKLPCF GRV+SWLV+A+GS  SD   + G   + E
Sbjct:    3 ETKIIYHLDDQETPYLVKLPIPAERVTLADFKHVLNKPNYKFFFKSMDDDFGVVKEEISDDNAKLPCFNGRVVSWLVSADGSHGSDGGSACGAESQAE 100          
BLAST of Dvl-2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001371.1 (pep scaffold:Pmarinus_7.0:GL492828:1505:4356:1 gene:ENSPMAG00000001236.1 transcript:ENSPMAT00000001371.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 154.066 bits (388), Expect = 1.500e-43
Identity = 67/129 (51.94%), Postives = 96/129 (74.42%), Query Frame = 2
Query: 1451 GFFGYPMGMPGQFSQGAGSIVTTSSSLPESERYQEELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGN 1837
            G+F  P   P +    A  +  T++         +ELHL+ ++D+ T+++ ++ P+SGL++RDR+WLKIT+PNAFIGS+LVDWL+ H+EGF DR++ARKYA NLLK G I+HTVNK+TFSEQCYY+ G+
Sbjct:   25 GYFTIPRSEPVRPIDPAAWVSHTAAMTGAYPYGFDELHLSIHSDMATVVKAMASPESGLEVRDRMWLKITIPNAFIGSDLVDWLFNHLEGFQDRRDARKYACNLLKAGLIRHTVNKITFSEQCYYIFGD 153          

HSP 2 Score: 85.5001 bits (210), Expect = 1.370e-19
Identity = 38/72 (52.78%), Postives = 48/72 (66.67%), Query Frame = 2
Query: 1100 PINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTAGASEPPSSVNGVHPQVSNLVAPSMQSLLS 1315
            PI L VAKCWDP P+GYFTIPR EPVRPIDP AWV HT AMT      P   + +H  + + +A  ++++ S
Sbjct:   10 PITLTVAKCWDPTPRGYFTIPRSEPVRPIDPAAWVSHTAAMTGAY---PYGFDELHLSIHSDMATVVKAMAS 78          
BLAST of Dvl-2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002205.1 (pep scaffold:Pmarinus_7.0:GL477144:51012:68257:1 gene:ENSPMAG00000001988.1 transcript:ENSPMAT00000002205.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 54.6842 bits (130), Expect = 9.706e-8
Identity = 34/82 (41.46%), Postives = 48/82 (58.54%), Query Frame = 2
Query:  896 LGISIVGQSNKGG--DGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQV----QKPGPINLVVAK 1123
            LG+S+ G  ++ G  D GIYV SI+ GGA A+DGR+  GD ++ VN       SN  A+ TLR  +     + G I+L VA+
Sbjct:  527 LGVSVKGNRSRDGAHDLGIYVKSIIAGGAAAKDGRLRIGDQLVAVNREPLLGRSNAAAMETLRRCMATDGSERGRIHLAVAR 608          
BLAST of Dvl-2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008444.1 (pep scaffold:Pmarinus_7.0:GL479496:14395:17295:-1 gene:ENSPMAG00000007646.1 transcript:ENSPMAT00000008444.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 47.3654 bits (111), Expect = 5.260e-7
Identity = 25/71 (35.21%), Postives = 42/71 (59.15%), Query Frame = 2
Query:  119 YHIDEEETPYLIKLSISPDKVTLGDLKNALNRP-HYKYFFKSMDDDF--GVVKEEITDDEAKLPCFKGRVI 322
            Y+   E  PY  +  +  D +TL   K  L +  +Y+++FK   ++F  GVV EE+ DD+A LP ++G+V+
Sbjct:   14 YYFCGEPIPY--RSRVRGDSLTLAHFKELLTKKGNYRFYFKKASEEFECGVVFEEVRDDKALLPLYQGKVV 82          
BLAST of Dvl-2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009066.1 (pep scaffold:Pmarinus_7.0:GL479913:2065:18580:1 gene:ENSPMAG00000008193.1 transcript:ENSPMAT00000009066.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 50.8322 bits (120), Expect = 1.484e-6
Identity = 28/71 (39.44%), Postives = 40/71 (56.34%), Query Frame = 2
Query:  866 VRLNMDTVKFLGISIVGQSN-KGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTL 1075
            V++N+   + LG SIV     +  + GIY+ SI+KGGA   DGRI  GD +L +N  S   +S   AV  +
Sbjct:  628 VQINLQKRQGLGFSIVAAKGPRQANIGIYIKSIIKGGAADLDGRIARGDQLLSINGTSLIGISEKRAVEIM 698          
BLAST of Dvl-2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006056.1 (pep scaffold:Pmarinus_7.0:GL477535:225:55869:1 gene:ENSPMAG00000005437.1 transcript:ENSPMAT00000006056.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 50.8322 bits (120), Expect = 1.601e-6
Identity = 30/82 (36.59%), Postives = 48/82 (58.54%), Query Frame = 2
Query:  896 LGISIVGQSNK--GGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQK----PGPINLVVAK 1123
            LG+S+ G  ++    D GI++ +I+ GGA A+DGR+   D ++ VN  S    SN +A+ +LR  + +    P  I LVVA+
Sbjct:  553 LGVSVKGTKDRRTNADLGIFIKTIIAGGAAAKDGRLRVDDQLIAVNRESLLGRSNLEAMESLRCAMSRDAGDPSLIQLVVAR 634          
BLAST of Dvl-2 vs. Ensembl Yeast
Match: IML1 (GTPase-activating protein (GAP) subunit of the Iml1p/SEACIT complex; SEACIT (Iml1p-Npr2p-Npr3p) is a subcomplex of the SEA complex, a coatomer-related complex that associates dynamically with the vacuole; Iml1p functions in the SEACIT complex as a GAP for the Rag family GTPase Gtr1p (EGOC subunit), resulting in the inhibition of TORC1 signaling in response to amino acid deprivation; the Iml1p/SEACIT complex is required for non-nitrogen-starvation (NNS)-induced autophagy [Source:SGD;Acc:S000003899])

HSP 1 Score: 48.1358 bits (113), Expect = 7.474e-6
Identity = 22/87 (25.29%), Postives = 43/87 (49.43%), Query Frame = 2
Query: 1565 LTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYY 1825
            L +N ++  +   + + +  + + +R W        F+GS +V+WL R+      R++A KY   ++K G   H +NK  F +  Y+
Sbjct: 1182 LNRNVELSKLAYQIQRGEDRITLVNRKWHWKKHEKCFVGSEMVNWLIRNFSDIDTREDAIKYGQKVMKEGLFVHVLNKHNFLDGHYF 1268          
BLAST of Dvl-2 vs. Ensembl Nematostella
Match: EDO39599 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S9L8])

HSP 1 Score: 212.616 bits (540), Expect = 1.485e-58
Identity = 96/130 (73.85%), Postives = 109/130 (83.85%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTAGASE 1240
            LNI+T+ LNMD V FLGISIVGQSNK GDGGIYVGS+MKGGAV  DGR+EPGDM+L+VND++FE+MSNDDAVR LRE V KPGPI L VAKCWDP PKGYFT+P  +PVRPID  AWV HT AM   A++
Sbjct:  245 LNIITITLNMDKVNFLGISIVGQSNKKGDGGIYVGSVMKGGAVDLDGRVEPGDMLLQVNDVNFENMSNDDAVRVLREMVHKPGPITLTVAKCWDPTPKGYFTLPHSDPVRPIDTSAWVQHTTAMNQFAAQ 374          

HSP 2 Score: 176.022 bits (445), Expect = 3.895e-46
Identity = 84/151 (55.63%), Postives = 109/151 (72.19%), Query Frame = 2
Query: 1532 PESERYQE---ELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRLSLDQVESVSEVGVNGPHHLAALP-----PPNFSSNKQP 1960
            PES+RY E      LT NTD+ T+++ ++ PDSGLDIRDR+WLKIT+PNAFIGS++VDWLY H+EGF DR+EARKYA NLLK GYI+HTVNK+TFSEQCYYV G+   N++ LSL++ E   +     P    A+P     PP +  ++ P
Sbjct:  405 PESDRYTEIPEGEALTINTDMSTVVKAMAAPDSGLDIRDRMWLKITIPNAFIGSDVVDWLYTHVEGFMDRREARKYACNLLKAGYIRHTVNKITFSEQCYYVFGDLCGNLAALSLNENEGDQDTLGPLPPQQQAIPWMTGGPPAYGYHQMP 555          

HSP 3 Score: 147.517 bits (371), Expect = 7.685e-37
Identity = 64/90 (71.11%), Postives = 78/90 (86.67%), Query Frame = 2
Query:  101 DETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALNRPHYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGSTVSDNVD 370
            DET++IYHID+E+TPYL+KL  +PD VTLGD KN LNRP+YK+FFKSMDDDFGVVKEEI+DDE  LPCF GRV++WLVT++ S+VS   D
Sbjct:    2 DETKVIYHIDDEDTPYLVKLGKTPDIVTLGDFKNVLNRPNYKFFFKSMDDDFGVVKEEISDDETHLPCFNGRVVAWLVTSDTSSVSGGGD 91          
BLAST of Dvl-2 vs. Ensembl Nematostella
Match: EDO39598 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S9L7])

HSP 1 Score: 167.933 bits (424), Expect = 1.797e-42
Identity = 85/135 (62.96%), Postives = 98/135 (72.59%), Query Frame = 2
Query:  881 DTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTAGAS-------EPPSSVNGV 1264
            D V FLGISIVGQSNK GDGGIYVGS+MKGGAV  DGR+EPGDM+L+VND++FE+MSNDDAVR LRE V KPGPI L VAKCWDP PKGYFT+P +     ID R     + +M  G +       E PSS  G+
Sbjct:  167 DKVNFLGISIVGQSNKKGDGGIYVGSVMKGGAVDLDGRVEPGDMLLQVNDVNFENMSNDDAVRVLREMVHKPGPITLTVAKCWDPTPKGYFTLPHKLLEVRID-RKITNWSGSMAIGVTTANPSMIEIPSSATGL 300          
BLAST of Dvl-2 vs. Ensembl Nematostella
Match: EDO46059 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RR65])

HSP 1 Score: 60.077 bits (144), Expect = 3.799e-10
Identity = 34/81 (41.98%), Postives = 52/81 (64.20%), Query Frame = 2
Query:  890 KFLGISIVGQSNKG---GDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAK 1123
            K LG SI G S      GD GIY+  I++GGA  QDGR++ GD I+ VN  + ED+S++DAV+ L+   ++   + +VV++
Sbjct:  109 KGLGFSIAGGSGNQHVPGDNGIYITKIIEGGAAQQDGRLQVGDKIISVNLQNLEDVSHEDAVQVLKATKER---VTIVVSR 186          
BLAST of Dvl-2 vs. Ensembl Nematostella
Match: EDO45887 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRU6])

HSP 1 Score: 59.6918 bits (143), Expect = 5.607e-9
Identity = 45/141 (31.91%), Postives = 70/141 (49.65%), Query Frame = 2
Query:  866 VRLNMDTVKFLGISIVGQ---SNKGGDG----GIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQK----PGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTAGASEPPSSV 1255
            + LNM     LG+S+ G+   ++ G D     GI+V S++ GGA  +DGR++  D +L VN++SF  ++N +A+  LR  +Q        I   VA+  DP      T+ R   V    P+   +     T    EPP+SV
Sbjct:  429 IPLNMSGAAGLGVSVKGKVADTDSGRDSPIDMGIFVKSVIAGGAAFKDGRLKAEDQLLSVNNVSFMRLTNTEAIDGLRRAMQNTRLGQAFIETTVARERDPQ-NDIGTVVRSHEVLKAPPQERSIEGGDHTPTRVEPPTSV 568          
BLAST of Dvl-2 vs. Ensembl Nematostella
Match: EDO37929 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SEC9])

HSP 1 Score: 54.6842 bits (130), Expect = 1.133e-7
Identity = 20/52 (38.46%), Postives = 39/52 (75.00%), Query Frame = 2
Query:  179 VTLGDLKNALNRPH-YKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWL 331
            +TL D K+  +RP  Y++ FK++D +FG VKEE+ +D+  +P ++G++++W+
Sbjct:  294 ITLRDFKHMFDRPGPYRFHFKALDPEFGTVKEEVIEDDDIIPGWEGKIVAWV 345          
BLAST of Dvl-2 vs. Ensembl Medaka
Match: dvl2 (dishevelled segment polarity protein 2 [Source:NCBI gene;Acc:101163770])

HSP 1 Score: 213.001 bits (541), Expect = 1.555e-57
Identity = 96/127 (75.59%), Postives = 111/127 (87.40%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTAG 1231
            LNI+TV LNM+   FLGISIVGQSN+ GDGGIY+GSIMKGGAVA DGRIEPGDM+L+VNDI+FE+MSNDDAVR LRE V KPGPI L VAKCWDP+P+GYFT+PR EP+RPIDP AWV H+ A++ G
Sbjct:  239 LNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDINFENMSNDDAVRVLREIVHKPGPIILTVAKCWDPSPQGYFTLPRNEPIRPIDPAAWVSHSVAVSGG 365          

HSP 2 Score: 159.073 bits (401), Expect = 1.075e-39
Identity = 72/132 (54.55%), Postives = 105/132 (79.55%), Query Frame = 2
Query: 1541 ERYQEELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRLSLDQVESVSEVGVNGPHHLAALPPP 1936
            ER+ ++ +L+ ++D+ ++ + ++ P+SGL++RDR+WLKIT+PNAF+GS++V+WL+ HIEGF DR+EARKYA+NLLK G+I+HTVNK+TFSEQCYYV G+  LNM+ LSL+  +  S  G +    LA LP P
Sbjct:  388 ERF-DDFNLSLHSDMASVAKAMASPESGLEVRDRMWLKITIPNAFLGSDVVEWLFHHIEGFQDRREARKYASNLLKAGFIRHTVNKITFSEQCYYVFGD--LNMANLSLNDNDGSS--GASDQDTLAPLPLP 514          

HSP 3 Score: 128.257 bits (321), Expect = 6.770e-30
Identity = 54/76 (71.05%), Postives = 66/76 (86.84%), Query Frame = 2
Query:  104 ETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALNRPHYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWL 331
            ET+IIYHIDEEETPYL+K+ I+ + +TL D K  LN+P+YK+FFKSMD DFGVVKEEI+DD AKLPCF GRV+SW+
Sbjct:    3 ETKIIYHIDEEETPYLVKIPIAAENITLLDFKQVLNKPNYKFFFKSMDQDFGVVKEEISDDSAKLPCFNGRVVSWV 78          
BLAST of Dvl-2 vs. Ensembl Medaka
Match: dvl2 (dishevelled segment polarity protein 2 [Source:NCBI gene;Acc:101163770])

HSP 1 Score: 212.616 bits (540), Expect = 3.893e-57
Identity = 96/127 (75.59%), Postives = 111/127 (87.40%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTAG 1231
            LNI+TV LNM+   FLGISIVGQSN+ GDGGIY+GSIMKGGAVA DGRIEPGDM+L+VNDI+FE+MSNDDAVR LRE V KPGPI L VAKCWDP+P+GYFT+PR EP+RPIDP AWV H+ A++ G
Sbjct:  253 LNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDINFENMSNDDAVRVLREIVHKPGPIILTVAKCWDPSPQGYFTLPRNEPIRPIDPAAWVSHSVAVSGG 379          

HSP 2 Score: 152.91 bits (385), Expect = 1.115e-37
Identity = 70/135 (51.85%), Postives = 104/135 (77.04%), Query Frame = 2
Query: 1541 ERYQEELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTL---NMSRLSLDQVESVSEVGVNGPHHLAALPPP 1936
            ER+ ++ +L+ ++D+ ++ + ++ P+SGL++RDR+WLKIT+PNAF+GS++V+WL+ HIEGF DR+EARKYA+NLLK G+I+HTVNK+TFSEQCYYV G+ +     M+ LSL+  +  S  G +    LA LP P
Sbjct:  402 ERF-DDFNLSLHSDMASVAKAMASPESGLEVRDRMWLKITIPNAFLGSDVVEWLFHHIEGFQDRREARKYASNLLKAGFIRHTVNKITFSEQCYYVFGDLSDCENYMANLSLNDNDGSS--GASDQDTLAPLPLP 533          

HSP 3 Score: 132.88 bits (333), Expect = 3.157e-31
Identity = 56/80 (70.00%), Postives = 70/80 (87.50%), Query Frame = 2
Query:  104 ETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALNRPHYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAE 343
            ET+IIYHIDEEETPYL+K+ I+ + +TL D K  LN+P+YK+FFKSMD DFGVVKEEI+DD AKLPCF GRV+SWLV+++
Sbjct:    3 ETKIIYHIDEEETPYLVKIPIAAENITLLDFKQVLNKPNYKFFFKSMDQDFGVVKEEISDDSAKLPCFNGRVVSWLVSSD 82          
BLAST of Dvl-2 vs. Ensembl Medaka
Match: dvl1a (dishevelled segment polarity protein 1 [Source:NCBI gene;Acc:101165393])

HSP 1 Score: 209.92 bits (533), Expect = 4.914e-57
Identity = 95/126 (75.40%), Postives = 108/126 (85.71%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTA 1228
            LNI+TV LNM+   FLGISIVGQSN  GDGGIY+GSIMKGGAVA DGRIEPGDM+L+VND++FE+MSNDDAVR LRE V K GPI+L VAKCWDP+P+ YFTIPR EPVRPIDP AW+ HT A+T 
Sbjct:  207 LNIITVTLNMEKYNFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRILREIVSKTGPISLTVAKCWDPSPRSYFTIPRAEPVRPIDPAAWISHTTALTG 332          

HSP 2 Score: 150.599 bits (379), Expect = 2.378e-37
Identity = 68/119 (57.14%), Postives = 92/119 (77.31%), Query Frame = 2
Query: 1577 TDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRLSLDQVESVSEVGVNGPHHLAALPP 1933
            TD+ TI++V+  PDSGL+IRDR+WLKIT+ NA IG+++VDWLY  +EGF DR++ARKYA++LLK GY++HTVNK+TFSEQCYY  G+   NM+ L+L++    S  G +    LA LPP
Sbjct:  349 TDMATIVKVMQLPDSGLEIRDRMWLKITIANAVIGADVVDWLYSRVEGFKDRRDARKYASSLLKHGYLRHTVNKITFSEQCYYTFGDLCQNMASLNLNE---GSSGGGSEQDTLAPLPP 464          

HSP 3 Score: 138.658 bits (348), Expect = 2.046e-33
Identity = 65/85 (76.47%), Postives = 73/85 (85.88%), Query Frame = 2
Query:  104 ETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALN-RP--HYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGS 349
            ET+IIYHIDEEETPYL+KLS+SP+KVTL D KN LN RP   YK+FFKSMD DFGVVKEEI+DD AKLPCF GRV+SWLV AE +
Sbjct:    3 ETKIIYHIDEEETPYLVKLSVSPEKVTLADFKNVLNNRPVNSYKFFFKSMDQDFGVVKEEISDDNAKLPCFNGRVVSWLVLAESA 87          
BLAST of Dvl-2 vs. Ensembl Medaka
Match: dvl1a (dishevelled segment polarity protein 1 [Source:NCBI gene;Acc:101165393])

HSP 1 Score: 211.075 bits (536), Expect = 7.566e-57
Identity = 95/126 (75.40%), Postives = 108/126 (85.71%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTA 1228
            LNI+TV LNM+   FLGISIVGQSN  GDGGIY+GSIMKGGAVA DGRIEPGDM+L+VND++FE+MSNDDAVR LRE V K GPI+L VAKCWDP+P+ YFTIPR EPVRPIDP AW+ HT A+T 
Sbjct:  252 LNIITVTLNMEKYNFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRILREIVSKTGPISLTVAKCWDPSPRSYFTIPRAEPVRPIDPAAWISHTTALTG 377          

HSP 2 Score: 151.369 bits (381), Expect = 2.737e-37
Identity = 68/119 (57.14%), Postives = 92/119 (77.31%), Query Frame = 2
Query: 1577 TDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRLSLDQVESVSEVGVNGPHHLAALPP 1933
            TD+ TI++V+  PDSGL+IRDR+WLKIT+ NA IG+++VDWLY  +EGF DR++ARKYA++LLK GY++HTVNK+TFSEQCYY  G+   NM+ L+L++    S  G +    LA LPP
Sbjct:  394 TDMATIVKVMQLPDSGLEIRDRMWLKITIANAVIGADVVDWLYSRVEGFKDRRDARKYASSLLKHGYLRHTVNKITFSEQCYYTFGDLCQNMASLNLNE---GSSGGGSEQDTLAPLPP 509          

HSP 3 Score: 139.428 bits (350), Expect = 2.076e-33
Identity = 65/85 (76.47%), Postives = 73/85 (85.88%), Query Frame = 2
Query:  104 ETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALN-RP--HYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGS 349
            ET+IIYHIDEEETPYL+KLS+SP+KVTL D KN LN RP   YK+FFKSMD DFGVVKEEI+DD AKLPCF GRV+SWLV AE +
Sbjct:    3 ETKIIYHIDEEETPYLVKLSVSPEKVTLADFKNVLNNRPVNSYKFFFKSMDQDFGVVKEEISDDNAKLPCFNGRVVSWLVLAESA 87          
BLAST of Dvl-2 vs. Ensembl Medaka
Match: dvl3a (dishevelled segment polarity protein 3 [Source:NCBI gene;Acc:101157324])

HSP 1 Score: 208.379 bits (529), Expect = 2.866e-56
Identity = 95/126 (75.40%), Postives = 107/126 (84.92%), Query Frame = 2
Query:  851 LNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTA 1228
            LNI+TV LNM+   FLGISIVGQSN+ GDGGIY+GSIMKGGAVA DGRIEPGDM+L+VNDI+FE+MSNDDAVR LR+ V KPGPI L VAKCWDPNP+  F +PR EP+RPIDP AWV HT AMT 
Sbjct:  243 LNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDINFENMSNDDAVRVLRDIVHKPGPITLTVAKCWDPNPRSCFALPRSEPIRPIDPAAWVSHTAAMTG 368          

HSP 2 Score: 169.088 bits (427), Expect = 3.888e-43
Identity = 82/157 (52.23%), Postives = 115/157 (73.25%), Query Frame = 2
Query: 1466 PMGMPGQFSQGAGSIVTTSSSLPESERYQEELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRLSLDQVESVSEVGVNGPHHLAALPPP 1936
            P GM    S    +  + SSS+PE+ER+ ++ HL+ ++D+ T+ + ++ P+SGL++RDR+WLKIT+ NAFIGS++VDWL+ H+EGFSDR+EARKYA+NLLK G+I+HTVNK+TFSEQCYYV G+   NM+ LSL   +  S  G +    L  LP P
Sbjct:  372 PYGMSPSMSTVTSTSSSISSSIPETERF-DDFHLSIHSDMATVAKAMACPESGLEVRDRMWLKITIANAFIGSDVVDWLFHHVEGFSDRREARKYASNLLKAGFIRHTVNKITFSEQCYYVFGDLCGNMAHLSLHDHDG-SSGGASDQDTLPPLPHP 526          

HSP 3 Score: 138.658 bits (348), Expect = 3.097e-33
Identity = 60/98 (61.22%), Postives = 78/98 (79.59%), Query Frame = 2
Query:  104 ETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALNRPHYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGSTVSDNVDSNGILDKNE 397
            ET+IIYH+D++ETPYL+KLS+  D+VTL D KN + +P+YK+FFKSMDDDFGVVKEEI+DD AKLPCF GRV+SWLV+ +G     + D+  + D  E
Sbjct:    3 ETKIIYHLDDQETPYLVKLSVPADRVTLADFKNVIKKPNYKFFFKSMDDDFGVVKEEISDDNAKLPCFNGRVVSWLVSGDGG----HADTGSVADSLE 96          
BLAST of Dvl-2 vs. Planmine SMEST
Match: SMESG000010246.1 (SMESG000010246.1)

HSP 1 Score: 1234.94 bits (3194), Expect = 0.000e+0
Identity = 775/775 (100.00%), Postives = 775/775 (100.00%), Query Frame = 2
Query:   65 MTNCATSGNVISDETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALNRPHYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGSTVSDNVDSNGILDKNESRMLPFQESHFPLINNIKASGGTTTNESXXXXXXXXXXXSVYSAAQDRVGPLRSFHDYKQAGRVAAHANRVNTNTPNGQNPIYETNXXXXXXXXXXXXXXXXXXXXXXXXXXTCTTMXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTAGASEPPSSVNGVHPQVSNLVAPSMQSLLSGGTMLXXXXXXXXXXXXXXYMPQPQNINQNTASVSTVGGPPGASVGFFGYPMGMPGQFSQGAGSIVTTSSSLPESERYQEELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRLSLDQVESVSEVGVNGPHHLAALPPPNFSSNKQPISSCINQPPLNINPQLTATSEPLPXXXXXXXXXXXXXXXQYSVVGPLPCXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXASSVSNMISKNPPPKIPPRTIASVSTNSTNPIISGFQNRGQSSVSQ 2389
            MTNCATSGNVISDETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALNRPHYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGSTVSDNVDSNGILDKNESRMLPFQESHFPLINNIKASGGTTTNESDTICDTCTDTDSVYSAAQDRVGPLRSFHDYKQAGRVAAHANRVNTNTPNGQNPIYETNSSMMSSDLESTSFFDSEDESSRFSTTTCTTMSSRYGRQKQQRRRRRPPAISRASSFSSITDSTMSLNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTAGASEPPSSVNGVHPQVSNLVAPSMQSLLSGGTMLAGTSAATFNAAAFGYMPQPQNINQNTASVSTVGGPPGASVGFFGYPMGMPGQFSQGAGSIVTTSSSLPESERYQEELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRLSLDQVESVSEVGVNGPHHLAALPPPNFSSNKQPISSCINQPPLNINPQLTATSEPLPSNNANVATATASSNSQYSVVGPLPCSQPSQHASSNASASAIKKSGSCNSLSGSSSSTSSSSSSNRSNTRINGNASSVSNMISKNPPPKIPPRTIASVSTNSTNPIISGFQNRGQSSVSQ
Sbjct:    1 MTNCATSGNVISDETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALNRPHYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGSTVSDNVDSNGILDKNESRMLPFQESHFPLINNIKASGGTTTNESDTICDTCTDTDSVYSAAQDRVGPLRSFHDYKQAGRVAAHANRVNTNTPNGQNPIYETNSSMMSSDLESTSFFDSEDESSRFSTTTCTTMSSRYGRQKQQRRRRRPPAISRASSFSSITDSTMSLNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTAGASEPPSSVNGVHPQVSNLVAPSMQSLLSGGTMLAGTSAATFNAAAFGYMPQPQNINQNTASVSTVGGPPGASVGFFGYPMGMPGQFSQGAGSIVTTSSSLPESERYQEELHLTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRLSLDQVESVSEVGVNGPHHLAALPPPNFSSNKQPISSCINQPPLNINPQLTATSEPLPSNNANVATATASSNSQYSVVGPLPCSQPSQHASSNASASAIKKSGSCNSLSGSSSSTSSSSSSNRSNTRINGNASSVSNMISKNPPPKIPPRTIASVSTNSTNPIISGFQNRGQSSVSQ 775          
BLAST of Dvl-2 vs. Planmine SMEST
Match: SMESG000049876.1 (SMESG000049876.1)

HSP 1 Score: 208.764 bits (530), Expect = 9.083e-56
Identity = 169/268 (63.06%), Postives = 203/268 (75.75%), Query Frame = 2
Query:  515 SVYSAAQDRVGPLRSFHDYKQAGRVAAHANRVNTN--------------------TPNGQNPIYETNXXXXXXXXXXXXXXXXXXXXXXXXXXTCTTMXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXLNIVTVRLNMDTVKFLGISIVGQSN---KGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTAGASEPP 1246
            S+Y+  +D+V PLR F D+K + ++    N   ++                     P  Q PIYE++SSMMSSDL++TSFFDSED+SSRFS+ T TTMSS+YG+Q++Q RRRR    +SRASSFSS+TDST+SLNI+TV LNMDTV FLGISIVGQ+N   + GDGGIYVGSIMKGGAVA DGRIEPGDMILEVN ISFE++SN++AVRTLREQVQK GP+ LVVAK WDPNP GY  +P+Q+PVRPIDPRAWVLHT AM  G   PP
Sbjct:  172 SIYN--EDKVPPLRKFSDFKHSVKLKKLRNAQGSHGNSNSSSNNNNSNSNNASNNAPAKQQPIYESSSSMMSSDLDTTSFFDSEDDSSRFSSATETTMSSKYGKQRRQLRRRRKMPHLSRASSFSSMTDSTVSLNIITVTLNMDTVPFLGISIVGQTNGNQENGDGGIYVGSIMKGGAVALDGRIEPGDMILEVNGISFENVSNEEAVRTLREQVQKLGPVTLVVAKSWDPNPTGYM-LPQQDPVRPIDPRAWVLHTQAM--GNMAPP 434          

HSP 2 Score: 150.214 bits (378), Expect = 8.091e-37
Identity = 69/105 (65.71%), Postives = 88/105 (83.81%), Query Frame = 2
Query:  101 DETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALNRPHYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGSTVSDNVDSNG----ILDKNESR 403
            +ETRIIY++D+EETPYLIK    P+++TLGD KNALNRP+YK+FFKS+DDDFGVVKEEITDD+AKLP   GRV+SWLV +EGST SDN  S+G    ++D ++S+
Sbjct:    2 EETRIIYYVDDEETPYLIKFHSPPEQITLGDFKNALNRPNYKFFFKSLDDDFGVVKEEITDDDAKLPYVNGRVVSWLVVSEGSTQSDNHSSSGKEVLLVDSDKSK 106          

HSP 3 Score: 149.443 bits (376), Expect = 1.312e-36
Identity = 68/112 (60.71%), Postives = 90/112 (80.36%), Query Frame = 2
Query: 1565 LTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRLSLD-QVESVSEVG 1897
            LT N +   I+R ++Q DSGL IRDRLWLKIT+ NAFIGS+LVDWLY H++GF+DRK+ARK+A NLLK G+I+HTVNK +FSEQCYYVL +    +S ++L+ +++SVS V 
Sbjct:  484 LTTNHEPSVIIRAMAQADSGLPIRDRLWLKITIYNAFIGSDLVDWLYSHVQGFTDRKDARKFATNLLKMGFIRHTVNKSSFSEQCYYVLNDMMGALSVMNLESEIDSVSVVA 595          
BLAST of Dvl-2 vs. Planmine SMEST
Match: SMESG000049876.1 (SMESG000049876.1)

HSP 1 Score: 209.149 bits (531), Expect = 2.083e-55
Identity = 169/268 (63.06%), Postives = 203/268 (75.75%), Query Frame = 2
Query:  515 SVYSAAQDRVGPLRSFHDYKQAGRVAAHANRVNTN--------------------TPNGQNPIYETNXXXXXXXXXXXXXXXXXXXXXXXXXXTCTTMXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXLNIVTVRLNMDTVKFLGISIVGQSN---KGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLVVAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTAGASEPP 1246
            S+Y+  +D+V PLR F D+K + ++    N   ++                     P  Q PIYE++SSMMSSDL++TSFFDSED+SSRFS+ T TTMSS+YG+Q++Q RRRR    +SRASSFSS+TDST+SLNI+TV LNMDTV FLGISIVGQ+N   + GDGGIYVGSIMKGGAVA DGRIEPGDMILEVN ISFE++SN++AVRTLREQVQK GP+ LVVAK WDPNP GY  +P+Q+PVRPIDPRAWVLHT AM  G   PP
Sbjct:  172 SIYN--EDKVPPLRKFSDFKHSVKLKKLRNAQGSHGNSNSSSNNNNSNSNNASNNAPAKQQPIYESSSSMMSSDLDTTSFFDSEDDSSRFSSATETTMSSKYGKQRRQLRRRRKMPHLSRASSFSSMTDSTVSLNIITVTLNMDTVPFLGISIVGQTNGNQENGDGGIYVGSIMKGGAVALDGRIEPGDMILEVNGISFENVSNEEAVRTLREQVQKLGPVTLVVAKSWDPNPTGYM-LPQQDPVRPIDPRAWVLHTQAM--GNMAPP 434          

HSP 2 Score: 150.599 bits (379), Expect = 1.002e-36
Identity = 69/105 (65.71%), Postives = 88/105 (83.81%), Query Frame = 2
Query:  101 DETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALNRPHYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGSTVSDNVDSNG----ILDKNESR 403
            +ETRIIY++D+EETPYLIK    P+++TLGD KNALNRP+YK+FFKS+DDDFGVVKEEITDD+AKLP   GRV+SWLV +EGST SDN  S+G    ++D ++S+
Sbjct:    2 EETRIIYYVDDEETPYLIKFHSPPEQITLGDFKNALNRPNYKFFFKSLDDDFGVVKEEITDDDAKLPYVNGRVVSWLVVSEGSTQSDNHSSSGKEVLLVDSDKSK 106          

HSP 3 Score: 149.828 bits (377), Expect = 1.520e-36
Identity = 68/112 (60.71%), Postives = 90/112 (80.36%), Query Frame = 2
Query: 1565 LTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHIEGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRLSLD-QVESVSEVG 1897
            LT N +   I+R ++Q DSGL IRDRLWLKIT+ NAFIGS+LVDWLY H++GF+DRK+ARK+A NLLK G+I+HTVNK +FSEQCYYVL +    +S ++L+ +++SVS V 
Sbjct:  484 LTTNHEPSVIIRAMAQADSGLPIRDRLWLKITIYNAFIGSDLVDWLYSHVQGFTDRKDARKFATNLLKMGFIRHTVNKSSFSEQCYYVLNDMMGALSVMNLESEIDSVSVVA 595          
BLAST of Dvl-2 vs. Planmine SMEST
Match: SMESG000056186.1 (SMESG000056186.1)

HSP 1 Score: 53.5286 bits (127), Expect = 1.010e-6
Identity = 27/74 (36.49%), Postives = 43/74 (58.11%), Query Frame = 2
Query:  857 IVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLR 1078
            + TV +     K LGIS++G+    G  G+Y+  ++KGG    DGR++PGD ILE+N   F + + + A   L+
Sbjct:  666 VSTVEITKKPSKGLGISVIGRE---GAKGVYICDVVKGGVADVDGRLKPGDQILEINGEDFRNETQEIAATRLK 736          
BLAST of Dvl-2 vs. Planmine SMEST
Match: SMESG000056186.1 (SMESG000056186.1)

HSP 1 Score: 53.1434 bits (126), Expect = 1.122e-6
Identity = 27/74 (36.49%), Postives = 43/74 (58.11%), Query Frame = 2
Query:  857 IVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIMKGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLR 1078
            + TV +     K LGIS++G+    G  G+Y+  ++KGG    DGR++PGD ILE+N   F + + + A   L+
Sbjct:  465 VSTVEITKKPSKGLGISVIGRE---GAKGVYICDVVKGGVADVDGRLKPGDQILEINGEDFRNETQEIAATRLK 535          
The following BLAST results are available for this feature:
BLAST of Dvl-2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
DVL31.717e-5676.19dishevelled segment polarity protein 3 [Source:HGN... [more]
DVL18.646e-5573.23dishevelled segment polarity protein 1 [Source:HGN... [more]
DVL29.254e-5573.02dishevelled segment polarity protein 2 [Source:HGN... [more]
DVL29.299e-5573.02dishevelled segment polarity protein 2 [Source:HGN... [more]
DVL11.484e-5473.23dishevelled segment polarity protein 1 [Source:HGN... [more]
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BLAST of Dvl-2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
dsh-14.585e-4364.57DiSHevelled related [Source:UniProtKB/TrEMBL;Acc:... [more]
dsh-11.135e-4264.57DiSHevelled related [Source:UniProtKB/TrEMBL;Acc:... [more]
dsh-16.731e-4264.57DiSHevelled related [Source:UniProtKB/TrEMBL;Acc:... [more]
dsh-19.258e-4264.57DiSHevelled related [Source:UniProtKB/TrEMBL;Acc:... [more]
dsh-11.092e-4164.57DiSHevelled related [Source:UniProtKB/TrEMBL;Acc:... [more]
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BLAST of Dvl-2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
dsh5.076e-6380.62gene:FBgn0000499 transcript:FBtr0073454[more]
baz1.514e-637.68gene:FBgn0000163 transcript:FBtr0111000[more]
baz1.672e-637.68gene:FBgn0000163 transcript:FBtr0343763[more]
baz1.757e-637.68gene:FBgn0000163 transcript:FBtr0343764[more]
baz1.782e-637.68gene:FBgn0000163 transcript:FBtr0074388[more]
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BLAST of Dvl-2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
dvl1a9.515e-5874.60dishevelled segment polarity protein 1a [Source:ZF... [more]
dvl21.576e-5775.59dishevelled segment polarity protein 2 [Source:ZFI... [more]
dvl3b2.143e-5776.38dishevelled segment polarity protein 3b [Source:ZF... [more]
dvl1b1.937e-5675.40dishevelled segment polarity protein 1b [Source:ZF... [more]
dvl1b2.376e-5675.40dishevelled segment polarity protein 1b [Source:ZF... [more]
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BLAST of Dvl-2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
dvl12.730e-5875.59dishevelled segment polarity protein 1 [Source:NCB... [more]
dvl12.817e-5775.59dishevelled segment polarity protein 1 [Source:NCB... [more]
dvl14.266e-5775.59dishevelled segment polarity protein 1 [Source:NCB... [more]
dvl35.005e-5675.40dishevelled segment polarity protein 3 [Source:NCB... [more]
dvl37.743e-5675.40dishevelled segment polarity protein 3 [Source:NCB... [more]
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BLAST of Dvl-2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Dvl39.419e-5776.19dishevelled segment polarity protein 3 [Source:MGI... [more]
Dvl31.024e-5676.19dishevelled segment polarity protein 3 [Source:MGI... [more]
Dvl24.807e-5570.15dishevelled segment polarity protein 2 [Source:MGI... [more]
Dvl24.807e-5570.15dishevelled segment polarity protein 2 [Source:MGI... [more]
Dvl24.807e-5570.15dishevelled segment polarity protein 2 [Source:MGI... [more]
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BLAST of Dvl-2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P51140|DSH_DROME5.089e-6280.62Segment polarity protein dishevelled OS=Drosophila... [more]
sp|Q61062|DVL3_MOUSE7.165e-5676.19Segment polarity protein dishevelled homolog DVL-3... [more]
sp|Q92997|DVL3_HUMAN8.246e-5676.19Segment polarity protein dishevelled homolog DVL-3... [more]
sp|B1WAP7|DVL3_XENTR4.102e-5575.40Segment polarity protein dishevelled homolog DVL-3... [more]
sp|Q05AS8|DVL2_XENTR5.093e-5573.81Segment polarity protein dishevelled homolog DVL-2... [more]
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BLAST of Dvl-2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
F2WMR50.000e+099.74Dvl-2 OS=Schmidtea mediterranea OX=79327 PE=2 SV=1[more]
B1NWV90.000e+099.63Dishevelled-like protein (Fragment) OS=Schmidtea m... [more]
D3J1K09.140e-9099.69Dishevelled (Fragment) OS=Schmidtea polychroa OX=5... [more]
A0A4Z2DKF81.289e-17052.99Putative Dishevelled segment polarity protein DVL-... [more]
A0A5K4EAL95.685e-16951.99Putative dishevelled OS=Schistosoma mansoni OX=618... [more]
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BLAST of Dvl-2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
dvl21.011e-5776.19dishevelled segment polarity protein 2 [Source:NCB... [more]
dvl1a1.041e-5776.19segment polarity protein dishevelled homolog DVL-1... [more]
dvl1b1.750e-5675.40segment polarity protein dishevelled homolog DVL-1... [more]
dvl3a1.228e-5573.81segment polarity protein dishevelled homolog DVL-3... [more]
dvl3b2.515e-5278.76dishevelled segment polarity protein 3b [Source:ZF... [more]
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BLAST of Dvl-2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSPMAT00000001371.11.500e-4351.94pep scaffold:Pmarinus_7.0:GL492828:1505:4356:1 gen... [more]
ENSPMAT00000002205.19.706e-841.46pep scaffold:Pmarinus_7.0:GL477144:51012:68257:1 g... [more]
ENSPMAT00000008444.15.260e-735.21pep scaffold:Pmarinus_7.0:GL479496:14395:17295:-1 ... [more]
ENSPMAT00000009066.11.484e-639.44pep scaffold:Pmarinus_7.0:GL479913:2065:18580:1 ge... [more]
ENSPMAT00000006056.11.601e-636.59pep scaffold:Pmarinus_7.0:GL477535:225:55869:1 gen... [more]
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BLAST of Dvl-2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
IML17.474e-625.29GTPase-activating protein (GAP) subunit of the Iml... [more]
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BLAST of Dvl-2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO395991.485e-5873.85Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO395981.797e-4262.96Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO460593.799e-1041.98Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO458875.607e-931.91Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO379291.133e-738.46Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Dvl-2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
dvl21.555e-5775.59dishevelled segment polarity protein 2 [Source:NCB... [more]
dvl23.893e-5775.59dishevelled segment polarity protein 2 [Source:NCB... [more]
dvl1a4.914e-5775.40dishevelled segment polarity protein 1 [Source:NCB... [more]
dvl1a7.566e-5775.40dishevelled segment polarity protein 1 [Source:NCB... [more]
dvl3a2.866e-5675.40dishevelled segment polarity protein 3 [Source:NCB... [more]
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BLAST of Dvl-2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000010246.10.000e+0100.00SMESG000010246.1[more]
SMESG000049876.19.083e-5663.06SMESG000049876.1[more]
SMESG000049876.12.083e-5563.06SMESG000049876.1[more]
SMESG000056186.11.010e-636.49SMESG000056186.1[more]
SMESG000056186.11.122e-636.49SMESG000056186.1[more]
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Cross References
External references for this transcript
DatabaseAccession
SmedGD GBrowseSMED30033103
GenBankADZ58512.1
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30033103 ID=SMED30033103|Name=Dvl-2|organism=Schmidtea mediterranea sexual|type=transcript|length=3159bp
TGTTGTTTGTTTAATTATAAAACCATAAATATTCATATTAAAATACTTAC
TGTAAACAGATAATATGACAAATTGTGCCACTAGTGGCAATGTTATTTCA
GATGAAACGAGAATTATCTATCACATAGACGAAGAAGAAACTCCATACTT
AATAAAATTATCAATCTCGCCTGATAAGGTCACTTTAGGAGATTTAAAAA
ATGCTCTCAATCGACCTCATTATAAATACTTTTTCAAATCGATGGACGAT
GATTTCGGAGTTGTTAAAGAAGAAATCACAGACGATGAAGCAAAATTGCC
GTGTTTCAAAGGCCGAGTTATTTCCTGGCTGGTTACAGCTGAAGGAAGCA
CAGTTTCCGATAATGTCGATTCTAATGGGATTTTGGATAAAAATGAATCT
CGCATGTTACCATTTCAGGAATCTCATTTCCCGTTGATAAACAATATCAA
AGCCAGTGGTGGAACCACAACTAATGAAAGTGATACGATTTGTGATACTT
GTACGGACACGGACTCGGTTTACAGTGCTGCTCAAGACAGAGTTGGTCCA
CTAAGAAGTTTCCACGATTATAAACAAGCCGGCCGGGTTGCTGCTCATGC
CAATCGCGTCAATACAAATACCCCAAACGGTCAGAATCCCATCTATGAAA
CCAATTCTTCAATGATGAGCTCCGACCTTGAATCAACCAGTTTTTTTGAT
TCGGAGGATGAATCTAGCAGGTTTTCGACTACTACATGTACAACTATGTC
TTCAAGATACGGGCGGCAGAAACAACAGAGACGCAGACGAAGGCCACCGG
CAATTAGCAGAGCCTCCTCATTCAGCAGTATTACAGACTCTACGATGTCT
CTCAATATCGTTACTGTTAGATTAAATATGGATACAGTTAAATTTCTTGG
TATCAGTATAGTTGGTCAATCTAATAAAGGTGGTGATGGCGGAATTTATG
TCGGTTCCATAATGAAAGGTGGTGCAGTAGCTCAGGACGGCAGAATCGAA
CCCGGTGATATGATTCTGGAAGTCAATGACATCAGTTTTGAAGACATGAG
CAATGATGATGCAGTACGCACTTTAAGAGAACAAGTCCAAAAACCAGGAC
CGATAAATCTAGTCGTTGCCAAATGTTGGGATCCTAATCCCAAGGGATAT
TTTACTATTCCTCGACAGGAACCTGTGAGACCTATAGATCCTAGAGCTTG
GGTCTTGCATACAAATGCCATGACAGCTGGTGCCAGTGAGCCCCCGTCCT
CAGTAAATGGAGTCCATCCACAAGTATCCAATTTGGTTGCACCTAGTATG
CAAAGTCTTTTATCTGGTGGCACAATGTTAGCGGGCACAAGTGCTGCTAC
ATTTAATGCTGCTGCATTTGGATACATGCCTCAACCACAGAATATTAATC
AGAATACCGCCTCAGTAAGTACTGTTGGAGGACCACCAGGAGCATCTGTA
GGTTTCTTTGGGTATCCAATGGGTATGCCAGGACAGTTTTCACAGGGTGC
CGGAAGTATTGTAACCACTTCGAGTTCTTTGCCTGAGTCAGAACGCTATC
AAGAAGAATTACATCTCACCAAAAACACGGACGTTGGAACTATATTAAGA
GTTTTATCACAACCCGATTCTGGCCTTGATATCCGGGATAGACTTTGGCT
GAAAATAACTCTTCCAAACGCTTTTATTGGCTCAAATCTCGTAGACTGGT
TATACAGGCATATTGAAGGGTTTTCTGATCGAAAAGAAGCTCGGAAATAC
GCCGCGAATCTGCTCAAATTTGGTTATATAAAGCACACAGTAAATAAAGT
CACGTTTTCAGAACAATGTTATTATGTCCTTGGTAATACTACCCTTAATA
TGAGTCGTCTCAGCCTCGATCAAGTAGAGAGCGTCTCTGAAGTAGGAGTT
AATGGTCCACATCATTTAGCCGCTCTTCCTCCTCCAAACTTCTCATCCAA
TAAGCAGCCTATATCATCATGTATCAATCAGCCTCCATTAAATATAAATC
CACAATTAACTGCAACATCAGAACCTCTACCTAGCAACAATGCTAATGTA
GCAACAGCAACTGCTAGTTCAAATAGTCAGTATAGTGTTGTTGGACCTTT
GCCGTGTTCTCAGCCATCACAACATGCATCGTCTAATGCATCTGCCTCAG
CCATTAAAAAATCCGGAAGTTGCAATAGCCTCTCTGGTAGCAGTTCTAGT
ACATCTTCATCTTCAAGTAGCAATAGAAGTAACACCAGAATCAACGGTAA
TGCCTCATCAGTCAGCAATATGATCTCAAAAAATCCACCTCCAAAGATAC
CACCAAGGACGATTGCTAGTGTTTCAACGAACTCCACAAATCCAATTATA
TCAGGATTTCAAAATCGTGGTCAGTCTTCAGTTAGTCAATAAAATCAGAT
CTACTCAAGATATCCAACTTGCAAATAACCATTTATTGACTTTAATAAGT
TTTATATTTAATTTCGTTTTACCATTGTGACGAAACTCGGTAAAGGAAAC
GCCAAAATCTATCAGAATCTATATTAATATGATCTTTCAAGTGTCATACA
GTTAGTGTGCCACCAAATTCATTATTATTATCCTAATCATATTATTATCA
TAATAATACTGTTGATAATAATAATAATAATTGTTGTTATTATTATTATT
ATTGATTATCGCCATCGGTGAATGTTTATAATGATCGATCAAATTTGTGA
TAACGCGACTTCGTTGCAATTTTTAATTTCAGTTTTAAATATTTTGATCA
GCTGTCGGTTATTATTTGTGAATAGACATGTTTTGTATATTTGAATGGGT
TATTAATACTATTGTTAATATCTGATCGGATACTGTGCGTTCTATTGCGT
GACTCTCCCCGTGTGTTTGAATGGCTGCTGCAGCTGCTGTTTTCGTGCAT
TGGTTTGTACTTGAGAATGGGTGGTGCGGTGTAACAGGCGTGAAATCAAT
TGTAATAGTTTGTTTGCCAGATTTGCATTACATAGTACCATAGTTCTCTT
TTCTTCTTTCTTTTTTTCTAATCGTGTCTATACATTAGACTTCCACATGA
ACATTCTTGATCTTTTCTATATATCATGTTTTTTCGCATGTCTAGCATTT
TATATGGAAGATTTATTGTAATTTCTTTTCTACCGATTTTGTGTCAACTG
GAAATCGGG
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protein sequence of SMED30033103-orf-1

>SMED30033103-orf-1 ID=SMED30033103-orf-1|Name=SMED30033103-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=776bp
MTNCATSGNVISDETRIIYHIDEEETPYLIKLSISPDKVTLGDLKNALNR
PHYKYFFKSMDDDFGVVKEEITDDEAKLPCFKGRVISWLVTAEGSTVSDN
VDSNGILDKNESRMLPFQESHFPLINNIKASGGTTTNESDTICDTCTDTD
SVYSAAQDRVGPLRSFHDYKQAGRVAAHANRVNTNTPNGQNPIYETNSSM
MSSDLESTSFFDSEDESSRFSTTTCTTMSSRYGRQKQQRRRRRPPAISRA
SSFSSITDSTMSLNIVTVRLNMDTVKFLGISIVGQSNKGGDGGIYVGSIM
KGGAVAQDGRIEPGDMILEVNDISFEDMSNDDAVRTLREQVQKPGPINLV
VAKCWDPNPKGYFTIPRQEPVRPIDPRAWVLHTNAMTAGASEPPSSVNGV
HPQVSNLVAPSMQSLLSGGTMLAGTSAATFNAAAFGYMPQPQNINQNTAS
VSTVGGPPGASVGFFGYPMGMPGQFSQGAGSIVTTSSSLPESERYQEELH
LTKNTDVGTILRVLSQPDSGLDIRDRLWLKITLPNAFIGSNLVDWLYRHI
EGFSDRKEARKYAANLLKFGYIKHTVNKVTFSEQCYYVLGNTTLNMSRLS
LDQVESVSEVGVNGPHHLAALPPPNFSSNKQPISSCINQPPLNINPQLTA
TSEPLPSNNANVATATASSNSQYSVVGPLPCSQPSQHASSNASASAIKKS
GSCNSLSGSSSSTSSSSSSNRSNTRINGNASSVSNMISKNPPPKIPPRTI
ASVSTNSTNPIISGFQNRGQSSVSQ*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000044cephalic ganglia
PLANA:0000062esophagus
PLANA:0000097ventral nerve cord
PLANA:0000136whole organism
PLANA:0000418head
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR036034PDZ_sf
IPR038207DIX_dom_sf
IPR036388WH-like_DNA-bd_sf
IPR026542Dsh
IPR015506Dsh/Dvl-rel
IPR036390WH_DNA-bd_sf
IPR008339Dishevelled_fam
IPR001478PDZ
IPR000591DEP_dom
IPR001158DIX
IPR011991WHTH_DNA-bd_dom
IPR003351Dishevelled_protein_dom
IPR029071Ubiquitin-like_domsf
Vocabulary: biological process
TermDefinition
GO:0016055Wnt signaling pathway
GO:0035556intracellular signal transduction
Vocabulary: molecular function
TermDefinition
GO:0005515protein binding
Vocabulary: cellular component
TermDefinition
GO:0005622intracellular
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR008339Dishevelled familyPRINTSPR01760DISHEVELLEDcoord: 342..356
score: 72.55
coord: 376..388
score: 56.11
IPR000591DEP domainSMARTSM00049DEP_3coord: 517..591
e-value: 1.8E-22
score: 90.7
IPR000591DEP domainPFAMPF00610DEPcoord: 520..587
e-value: 1.3E-14
score: 54.0
IPR000591DEP domainPROSITEPS50186DEPcoord: 517..591
score: 27.045
IPR001478PDZ domainSMARTSM00228pdz_newcoord: 276..355
e-value: 2.2E-16
score: 70.4
IPR001478PDZ domainPFAMPF00595PDZcoord: 268..351
e-value: 1.6E-17
score: 63.6
IPR001478PDZ domainPROSITEPS50106PDZcoord: 267..339
score: 19.199
IPR001158DIX domainSMARTSM00021dax_2coord: 12..93
e-value: 2.7E-47
score: 173.1
IPR001158DIX domainPFAMPF00778DIXcoord: 14..90
e-value: 2.5E-30
score: 104.1
IPR001158DIX domainPROSITEPS50841DIXcoord: 12..93
score: 28.713
IPR003351Dishevelled protein domainPFAMPF02377Dishevelledcoord: 138..263
e-value: 4.6E-34
score: 118.2
IPR036034PDZ superfamilyGENE3DG3DSA:2.30.42.10coord: 260..359
e-value: 3.9E-30
score: 105.9
IPR036034PDZ superfamilySUPERFAMILYSSF50156PDZ domain-likecoord: 244..356
IPR038207DIX domain superfamilyGENE3DG3DSA:3.10.20.380coord: 12..91
e-value: 1.6E-36
score: 126.0
IPR036388Winged helix-like DNA-binding domain superfamilyGENE3DG3DSA:1.10.10.10coord: 486..591
e-value: 1.8E-30
score: 106.7
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 749..775
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 703..775
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 206..253
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 206..233
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 703..739
NoneNo IPR availableCDDcd04438DEP_dishevelledcoord: 509..590
e-value: 4.24145E-48
score: 162.512
NoneNo IPR availableCDDcd00992PDZ_signalingcoord: 265..352
e-value: 2.77726E-20
score: 83.7702
IPR026542Dishevelled DshPANTHERPTHR10878:SF25SEGMENT POLARITY PROTEIN DISHEVELLEDcoord: 14..736
IPR015506Dishevelled-related proteinPANTHERPTHR10878SEGMENT POLARITY PROTEIN DISHEVELLEDcoord: 14..736
IPR029071Ubiquitin-like domain superfamilySUPERFAMILYSSF54236Ubiquitin-likecoord: 13..91
IPR036390Winged helix DNA-binding domain superfamilySUPERFAMILYSSF46785"Winged helix" DNA-binding domaincoord: 501..605