Phosphatidylinositol-4,5-bisphosphate 4-phosphatase

Overview
NamePhosphatidylinositol-4,5-bisphosphate 4-phosphatase
Smed IDSMED30033014
Length (bp)900
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase (SMED30033014) t-SNE clustered cells

Violin plots show distribution of expression levels for Phosphatidylinositol-4,5-bisphosphate 4-phosphatase (SMED30033014) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase (SMED30033014) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Phosphatidylinositol-4,5-bisphosphate 4-phosphatase (SMED30033014) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30033014

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 6

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
pharynxSMED30033014h1SMcG0011534 Contig1068GPL15192PMID:23079596
Forsthoefel et al., 2012		whole organism asexual adult colorimetric in situ hybridization evidence
gutSMED30033014h1SMcG0011534 Contig1068GPL15192PMID:23079596
Forsthoefel et al., 2012		whole organism asexual adult colorimetric in situ hybridization evidence
intestinal phagocyteSMED30033014h1SMcG0011534 Contig1068GPL15192PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
gutSMED30033014h1SMcG0011534 dd_Smed_v4_1079_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30033014h1SMcG0011534 dd_Smed_v4_1079_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30033014h1SMcG0011534 dd_Smed_v4_1079_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Human
Match: PIP4P2 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 [Source:HGNC Symbol;Acc:HGNC:25452])

HSP 1 Score: 130.568 bits (327), Expect = 9.234e-36
Identity = 86/208 (41.35%), Postives = 132/208 (63.46%), Query Frame = 1 
Query:  190 INCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQ--SVRVTCVNCSSAFIISVQKQKKF-MVAKCPHCQKNSSIGPWYARIRWXXXXXXXXXXXXXXXXVTVGXXXXXXXXXXXXVAYVGLFLSGIILFVKGSFYCCMPISTIETSLS 804
            INC+VC+++I+LD K++  VVKC  CNEATPIK  P GKKYVRC CN LLICK +S R+GCPRP+C+ +INL      + ++    +Q  L  Q    RV C +C + F+     + +F  +AKCPHC+K SS+G    R R   Y+ +G+I I +G+G+TVGT   + ++++ YV++   +L G+I  ++  ++  + +S  E S +
Sbjct:   56 INCRVCQSLINLDGKLHQHVVKCTVCNEATPIKNPPTGKKYVRCPCNCLLICKDTSRRIGCPRPNCRRIINLGPV---MLISEEQPAQPALPIQPEGTRVVCGHCGNTFL---WMELRFNTLAKCPHCKKISSVGSALPRRRCCAYITIGMICIFIGVGLTVGTPDFARRFRATYVSWAIAYLLGLICLIRACYWGAIRVSYPEHSFA 257
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Human
Match: PIP4P2 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 [Source:HGNC Symbol;Acc:HGNC:25452])

HSP 1 Score: 128.642 bits (322), Expect = 5.103e-35
Identity = 83/195 (42.56%), Postives = 126/195 (64.62%), Query Frame = 1 
Query:  190 INCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQ--SVRVTCVNCSSAFIISVQKQKKF-MVAKCPHCQKNSSIGPWYARIRWXXXXXXXXXXXXXXXXVTVGXXXXXXXXXXXXVAYVGLFLSGIILFVKGSFY 765
            INC+VC+++I+LD K++  VVKC  CNEATPIK  P GKKYVRC CN LLICK +S R+GCPRP+C+ +INL      + ++    +Q  L  Q    RV C +C + F+     + +F  +AKCPHC+K SS+G    R R   Y+ +G+I I +G+G+TVGT   + ++++ YV++   +L G+I  ++  ++
Sbjct:   62 INCRVCQSLINLDGKLHQHVVKCTVCNEATPIKNPPTGKKYVRCPCNCLLICKDTSRRIGCPRPNCRRIINLGPV---MLISEEQPAQPALPIQPEGTRVVCGHCGNTFL---WMELRFNTLAKCPHCKKISSVGSALPRRRCCAYITIGMICIFIGVGLTVGTPDFARRFRATYVSWAIAYLLGLICLIRACYW 250
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Human
Match: PIP4P1 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 [Source:HGNC Symbol;Acc:HGNC:19299])

HSP 1 Score: 126.331 bits (316), Expect = 7.456e-34
Identity = 83/198 (41.92%), Postives = 117/198 (59.09%), Query Frame = 1 
Query:  190 INCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQSVRVTCVNCSSAFIISVQKQKKFMVAKCPHCQKNSSIGPWYARIRWXXXXXXXXXXXXXXXXVTVGXXXXXXXXXXXXVAYVGLFLSGIILFVKGSFYCCMPIS 783
            I C+VC+++I+++ KM+  VVKC  CNEATPIK APPGKKYVRC CN LLICK +S R+ CPRP+CK +INL        V  G  S        VRV C +C + F+ +    +   +A+CPHC+K SSIG  Y R R I   +LGL+      G+  GT+  + +Y   Y A+  + L  ++   +  ++ CM +S
Sbjct:   82 ITCRVCQSLINVEGKMHQHVVKCGVCNEATPIKNAPPGKKYVRCPCNCLLICKVTSQRIACPRPYCKRIINLGP------VHPGPLSPEP-QPMGVRVICGHCKNTFLWTEFTDR--TLARCPHCRKVSSIGRRYPRKRCICCFLLGLLLAVTATGLAFGTWKHARRYGGIYAAWAFVILLAVLCLGRALYWACMKVS 270
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Human
Match: PIP4P1 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 [Source:HGNC Symbol;Acc:HGNC:19299])

HSP 1 Score: 126.331 bits (316), Expect = 7.709e-34
Identity = 83/198 (41.92%), Postives = 117/198 (59.09%), Query Frame = 1 
Query:  190 INCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQSVRVTCVNCSSAFIISVQKQKKFMVAKCPHCQKNSSIGPWYARIRWXXXXXXXXXXXXXXXXVTVGXXXXXXXXXXXXVAYVGLFLSGIILFVKGSFYCCMPIS 783
            I C+VC+++I+++ KM+  VVKC  CNEATPIK APPGKKYVRC CN LLICK +S R+ CPRP+CK +INL        V  G  S        VRV C +C + F+ +    +   +A+CPHC+K SSIG  Y R R I   +LGL+      G+  GT+  + +Y   Y A+  + L  ++   +  ++ CM +S
Sbjct:   89 ITCRVCQSLINVEGKMHQHVVKCGVCNEATPIKNAPPGKKYVRCPCNCLLICKVTSQRIACPRPYCKRIINLGP------VHPGPLSPEP-QPMGVRVICGHCKNTFLWTEFTDR--TLARCPHCRKVSSIGRRYPRKRCICCFLLGLLLAVTATGLAFGTWKHARRYGGIYAAWAFVILLAVLCLGRALYWACMKVS 277
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Human
Match: PIP4P2 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 [Source:HGNC Symbol;Acc:HGNC:25452])

HSP 1 Score: 108.227 bits (269), Expect = 3.543e-28
Identity = 55/111 (49.55%), Postives = 75/111 (67.57%), Query Frame = 1 
Query:  190 INCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQ--SVRVTCVNCSSAFII 516
            INC+VC+++I+LD K++  VVKC  CNEATPIK  P GKKYVRC CN LLICK +S R+GCPRP+C+ +INL      + ++    +Q  L  Q    RV C +C + F++
Sbjct:   56 INCRVCQSLINLDGKLHQHVVKCTVCNEATPIKNPPTGKKYVRCPCNCLLICKDTSRRIGCPRPNCRRIINLGPV---MLISEEQPAQPALPIQPEGTRVVCGHCGNTFLL 163
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Celegans
Match: Y71H2AM.2 (Phosphatidylinositol-4,5-bisphosphate 4-phosphatase [Source:UniProtKB/TrEMBL;Acc:Q9BL29])

HSP 1 Score: 118.627 bits (296), Expect = 1.169e-31
Identity = 62/138 (44.93%), Postives = 88/138 (63.77%), Query Frame = 1 
Query:  187 SINCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQSVRVTCVNCSSAFIISVQKQKKFMVAKCPHCQKNSSIGPWYAR 600
            ++ C+VC   +SL+ +    VVKC++C+EATPI+ APPGKKYVRC CN LLICK+SS+R+ CPR +C+ VI LA   D     T + + TG    S RV C +C+  F+ +        +A CPHC+K S++G +  R
Sbjct:   58 TVLCRVCDVAVSLEGRNQQHVVKCHSCDEATPIRPAPPGKKYVRCPCNCLLICKASSTRIACPRNNCRRVITLAGQRDP---GTAIRAPTG----SCRVKCNHCNEIFLFNTLTNA---LANCPHCKKYSTVGSFARR 185
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Fly
Match: CG6707 (gene:FBgn0036058 transcript:FBtr0076358)

HSP 1 Score: 135.961 bits (341), Expect = 2.013e-38
Identity = 88/220 (40.00%), Postives = 130/220 (59.09%), Query Frame = 1 
Query:  142 IPLPDSQENGNTLTNSINCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQSVRVTCVNCSSAFIISVQKQKKFMVAKCPHCQKNSSIGPWYARIRWXXXXXXXXXXXXXXXXVTVGXXXXXXXXXXXXVAYVGLFLSGIILFVKGSFYCCMPISTIETSL 801
            +P P  Q         + C+VC+++I +  K    VVKC +CNEATPI+ AP GKKYVRC CN LLICKSSS R+ CPRP+CK +INLA +     V   V +  G+     RVTC +CS  F+ +        +A+CPHC+K SS+G  +A  R +++ I+ L+F+  GI VT+GTY+ +  +   Y  YV LF+    +  + ++Y  + +S I+  +
Sbjct:   23 LPPPYQQSTNTGGVPMVTCRVCQHMIDITTKREQHVVKCTHCNEATPIRNAPAGKKYVRCPCNCLLICKSSSQRIACPRPNCKRIINLAPSP----VTPPVPTMPGM----CRVTCGHCSDTFLFNTYHNA---LARCPHCRKVSSVGSRFANSRAVMFAIVALVFLITGIAVTIGTYSIASDHGGMYFLYVALFVISGCMLARSAYYFRLKVSAIDGPM 231
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Fly
Match: CG6707 (gene:FBgn0036058 transcript:FBtr0076357)

HSP 1 Score: 135.961 bits (341), Expect = 5.464e-38
Identity = 88/220 (40.00%), Postives = 130/220 (59.09%), Query Frame = 1 
Query:  142 IPLPDSQENGNTLTNSINCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQSVRVTCVNCSSAFIISVQKQKKFMVAKCPHCQKNSSIGPWYARIRWXXXXXXXXXXXXXXXXVTVGXXXXXXXXXXXXVAYVGLFLSGIILFVKGSFYCCMPISTIETSL 801
            +P P  Q         + C+VC+++I +  K    VVKC +CNEATPI+ AP GKKYVRC CN LLICKSSS R+ CPRP+CK +INLA +     V   V +  G+     RVTC +CS  F+ +        +A+CPHC+K SS+G  +A  R +++ I+ L+F+  GI VT+GTY+ +  +   Y  YV LF+    +  + ++Y  + +S I+  +
Sbjct:   58 LPPPYQQSTNTGGVPMVTCRVCQHMIDITTKREQHVVKCTHCNEATPIRNAPAGKKYVRCPCNCLLICKSSSQRIACPRPNCKRIINLAPSP----VTPPVPTMPGM----CRVTCGHCSDTFLFNTYHNA---LARCPHCRKVSSVGSRFANSRAVMFAIVALVFLITGIAVTIGTYSIASDHGGMYFLYVALFVISGCMLARSAYYFRLKVSAIDGPM 266
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Fly
Match: CG6707 (gene:FBgn0036058 transcript:FBtr0076356)

HSP 1 Score: 135.961 bits (341), Expect = 5.464e-38
Identity = 88/220 (40.00%), Postives = 130/220 (59.09%), Query Frame = 1 
Query:  142 IPLPDSQENGNTLTNSINCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQSVRVTCVNCSSAFIISVQKQKKFMVAKCPHCQKNSSIGPWYARIRWXXXXXXXXXXXXXXXXVTVGXXXXXXXXXXXXVAYVGLFLSGIILFVKGSFYCCMPISTIETSL 801
            +P P  Q         + C+VC+++I +  K    VVKC +CNEATPI+ AP GKKYVRC CN LLICKSSS R+ CPRP+CK +INLA +     V   V +  G+     RVTC +CS  F+ +        +A+CPHC+K SS+G  +A  R +++ I+ L+F+  GI VT+GTY+ +  +   Y  YV LF+    +  + ++Y  + +S I+  +
Sbjct:   58 LPPPYQQSTNTGGVPMVTCRVCQHMIDITTKREQHVVKCTHCNEATPIRNAPAGKKYVRCPCNCLLICKSSSQRIACPRPNCKRIINLAPSP----VTPPVPTMPGM----CRVTCGHCSDTFLFNTYHNA---LARCPHCRKVSSVGSRFANSRAVMFAIVALVFLITGIAVTIGTYSIASDHGGMYFLYVALFVISGCMLARSAYYFRLKVSAIDGPM 266
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Zebrafish
Match: pip4p2 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 [Source:ZFIN;Acc:ZDB-GENE-060503-854])

HSP 1 Score: 132.109 bits (331), Expect = 1.531e-36
Identity = 88/208 (42.31%), Postives = 132/208 (63.46%), Query Frame = 1 
Query:  190 INCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQ--SVRVTCVNCSSAFIISVQKQKKF-MVAKCPHCQKNSSIGPWYARIRWXXXXXXXXXXXXXXXXVTVGXXXXXXXXXXXXVAYVGLFLSGIILFVKGSFYCCMPISTIETSLS 804
            INC+VC+++I+LD K++  VVKC  CNEATPIK  P GKKYVRC CN LLICK +S R+GCPRP+C+ +INL+     + +     +Q  L  Q   +RV C +C + F+     + +F  +AKCPHC+K SS+G    R R   Y+ +G+I I +GIG+TVGT   + +Y + YV++   +L G+I  V+  ++  + +S  E + +
Sbjct:   56 INCRVCQSLITLDGKLHQHVVKCTVCNEATPIKNPPTGKKYVRCPCNCLLICKDTSRRIGCPRPNCRRIINLSPV---MVIPEEQPAQPALPVQPEGMRVVCGHCGNTFL---WMELRFNTLAKCPHCKKISSVGSALPRRRCCAYITVGMICIFIGIGLTVGTQDFARRYHATYVSWAFAYLLGLICLVRACYWGAIKVSYPENTFA 257
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Zebrafish
Match: pip4p2 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 [Source:ZFIN;Acc:ZDB-GENE-060503-854])

HSP 1 Score: 132.109 bits (331), Expect = 1.531e-36
Identity = 88/208 (42.31%), Postives = 132/208 (63.46%), Query Frame = 1 
Query:  190 INCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQ--SVRVTCVNCSSAFIISVQKQKKF-MVAKCPHCQKNSSIGPWYARIRWXXXXXXXXXXXXXXXXVTVGXXXXXXXXXXXXVAYVGLFLSGIILFVKGSFYCCMPISTIETSLS 804
            INC+VC+++I+LD K++  VVKC  CNEATPIK  P GKKYVRC CN LLICK +S R+GCPRP+C+ +INL+     + +     +Q  L  Q   +RV C +C + F+     + +F  +AKCPHC+K SS+G    R R   Y+ +G+I I +GIG+TVGT   + +Y + YV++   +L G+I  V+  ++  + +S  E + +
Sbjct:   56 INCRVCQSLITLDGKLHQHVVKCTVCNEATPIKNPPTGKKYVRCPCNCLLICKDTSRRIGCPRPNCRRIINLSPV---MVIPEEQPAQPALPVQPEGMRVVCGHCGNTFL---WMELRFNTLAKCPHCKKISSVGSALPRRRCCAYITVGMICIFIGIGLTVGTQDFARRYHATYVSWAFAYLLGLICLVRACYWGAIKVSYPENTFA 257
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Zebrafish
Match: pip4p1b (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1b [Source:NCBI gene;Acc:553253])

HSP 1 Score: 129.413 bits (324), Expect = 1.832e-35
Identity = 99/251 (39.44%), Postives = 140/251 (55.78%), Query Frame = 1 
Query:   55 DIMSKEKLVDFEEIPEFSNPQNFQNTFVTIPL-----PDSQENGNTLTNS---INCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQSVRVTCVNCSSAFIISVQKQKKFMVAKCPHCQKNSSIGPWYARIRWXXXXXXXXXXXXXXXXVTVGXXXXXXXXXXXXVAYVGLFLSGIILFVKGSFYCCMPIS 783
            D M+   L D E     S PQNF       P+     P     G+  ++S   I+C+VC+++IS++ K++  VVKC  CNEATPIK AP GKKYVRC CN LLICK +S R+ CPRP+CK VINL       G  +     TG      RV+C +C+  F+ +    +   +A+CPHC+K SSIG  Y R R +I  +L LIF+    G+  GT+  + +YK  Y ++V   +  ++  V+   + CM IS
Sbjct:   15 DGMTGLSLGD-EPYRPISKPQNFAVFPSAPPMLGEAPPPYSPLGSPESSSAPVISCRVCQSLISVEGKIHQHVVKCGVCNEATPIKNAPAGKKYVRCPCNCLLICKVTSQRIACPRPYCKRVINLGPVNP--GAGSPNPQPTG-----ARVSCGHCAKTFLWTEFTDR--TLARCPHCRKVSSIGQRYPRKRSLICFLLCLIFVITTAGLIAGTWLKAQKYKGIYASWVFFIVLVLVTLVRALHWACMKIS 255
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Zebrafish
Match: pip4p1a (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1a [Source:NCBI gene;Acc:556136])

HSP 1 Score: 126.716 bits (317), Expect = 2.789e-34
Identity = 78/186 (41.94%), Postives = 107/186 (57.53%), Query Frame = 1 
Query:   55 DIMSKEKLVDFEEIPEFSNPQNF--QNTFVTIPLPDSQENGNTLTNSINCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQSVRVTCVNCSSAFIISVQKQKKFMVAKCPHCQKNSSIGPWYARIR 606
             + +  K   F   P  + P     +N     PL  S E+G+     I+C+VC+++IS++ K++  VVKC  CNEATPIK AP GKKYVRC CN LLICK +S R+ CPRP+CK +INL       G A+      G      RV+C +CS+ F+ +    +   +A+CPHC+K SSIG  Y R R
Sbjct:   31 SLGAPNKPQSFPPFPSSTQPPVLLSENPPPYSPL-TSPESGSAPV--ISCRVCQSLISVEGKIHQHVVKCGVCNEATPIKNAPAGKKYVRCPCNCLLICKVTSQRIACPRPYCKRIINLGPV--HPGPASPDPQPAG-----ARVSCGHCSNTFLWTEFTDR--TLARCPHCRKVSSIGQRYPRRR 204
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Zebrafish
Match: pip4p1a (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1a [Source:NCBI gene;Acc:556136])

HSP 1 Score: 126.716 bits (317), Expect = 2.789e-34
Identity = 78/186 (41.94%), Postives = 107/186 (57.53%), Query Frame = 1 
Query:   55 DIMSKEKLVDFEEIPEFSNPQNF--QNTFVTIPLPDSQENGNTLTNSINCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQSVRVTCVNCSSAFIISVQKQKKFMVAKCPHCQKNSSIGPWYARIR 606
             + +  K   F   P  + P     +N     PL  S E+G+     I+C+VC+++IS++ K++  VVKC  CNEATPIK AP GKKYVRC CN LLICK +S R+ CPRP+CK +INL       G A+      G      RV+C +CS+ F+ +    +   +A+CPHC+K SSIG  Y R R
Sbjct:   31 SLGAPNKPQSFPPFPSSTQPPVLLSENPPPYSPL-TSPESGSAPV--ISCRVCQSLISVEGKIHQHVVKCGVCNEATPIKNAPAGKKYVRCPCNCLLICKVTSQRIACPRPYCKRIINLGPV--HPGPASPDPQPAG-----ARVSCGHCSNTFLWTEFTDR--TLARCPHCRKVSSIGQRYPRRR 204
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Xenopus
Match: pip4p2 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 [Source:NCBI gene;Acc:448483])

HSP 1 Score: 129.028 bits (323), Expect = 3.785e-35
Identity = 85/208 (40.87%), Postives = 128/208 (61.54%), Query Frame = 1 
Query:  190 INCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQ--SVRVTCVNCSSAFIISVQKQKKF-MVAKCPHCQKNSSIGPWYARIRWXXXXXXXXXXXXXXXXVTVGXXXXXXXXXXXXVAYVGLFLSGIILFVKGSFYCCMPISTIETSLS 804
            INC+VC+++I+LD K++  VVKC  CNEATPIK  P GKKYVRC CN LLICK  S R+GCPRP+C+ +INL      + +     +Q  L  Q    RV C +C + F+     + +F  +AKCPHC+K SS+G    R R   Y+ +G+I I +G+G+TVGT   + ++ + YV++   +L G++  ++  ++  +  S  E S +
Sbjct:   55 INCRVCQSLINLDGKLHQHVVKCTVCNEATPIKTPPLGKKYVRCPCNCLLICKDISRRIGCPRPNCRRIINLGPV---MLIPEEQPAQPALPVQPEGTRVVCGHCGNTFL---WMELRFNTLAKCPHCKKISSVGSALPRRRCCTYITMGMICIFIGVGLTVGTQDFARRFHATYVSWAVAYLVGLVCLIRACYWGAIKFSYPEHSFA 256
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Xenopus
Match: pip4p1 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 [Source:NCBI gene;Acc:100170610])

HSP 1 Score: 120.553 bits (301), Expect = 2.465e-31
Identity = 70/150 (46.67%), Postives = 93/150 (62.00%), Query Frame = 1 
Query:  157 SQENGNTLTNSINCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQSVRVTCVNCSSAFIISVQKQKKFMVAKCPHCQKNSSIGPWYARIR 606
            S E+G+     I C+VC+++I+++ KM+  VVKC  CNEATPIK AP GKKYVRC CN LLICK +S R+ CPRP+CK +INL       G  +      G     VRV C +C + F+ +    +   +A+CPHC+K SSIG  Y R R
Sbjct:  123 SPESGSAPM--ITCRVCQSLINVEGKMHQHVVKCGVCNEATPIKNAPQGKKYVRCPCNCLLICKVTSQRIACPRPYCKRIINLGPV--HAGPLSPEPQPVG-----VRVICGHCKNNFLWTEFTDR--ALARCPHCRKVSSIGMRYPRKR 261
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Xenopus
Match: pip4p2 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 [Source:NCBI gene;Acc:448483])

HSP 1 Score: 117.857 bits (294), Expect = 9.071e-31
Identity = 85/228 (37.28%), Postives = 128/228 (56.14%), Query Frame = 1 
Query:  190 INCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQ--SVRVTCVNCSSAFIISVQKQKKF-MVAKCPHCQK--------------------NSSIGPWYARIRWXXXXXXXXXXXXXXXXVTVGXXXXXXXXXXXXVAYVGLFLSGIILFVKGSFYCCMPISTIETSLS 804
            INC+VC+++I+LD K++  VVKC  CNEATPIK  P GKKYVRC CN LLICK  S R+GCPRP+C+ +INL      + +     +Q  L  Q    RV C +C + F+     + +F  +AKCPHC+K                     SS+G    R R   Y+ +G+I I +G+G+TVGT   + ++ + YV++   +L G++  ++  ++  +  S  E S +
Sbjct:   55 INCRVCQSLINLDGKLHQHVVKCTVCNEATPIKTPPLGKKYVRCPCNCLLICKDISRRIGCPRPNCRRIINLGPV---MLIPEEQPAQPALPVQPEGTRVVCGHCGNTFL---WMELRFNTLAKCPHCKKMNCQVPRIQGKNGSAPGKAFRSSVGSALPRRRCCTYITMGMICIFIGVGLTVGTQDFARRFHATYVSWAVAYLVGLVCLIRACYWGAIKFSYPEHSFA 276
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Mouse
Match: Pip4p2 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 [Source:MGI Symbol;Acc:MGI:1919769])

HSP 1 Score: 129.798 bits (325), Expect = 1.372e-35
Identity = 85/208 (40.87%), Postives = 129/208 (62.02%), Query Frame = 1 
Query:  190 INCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQ--SVRVTCVNCSSAFIISVQKQKKF-MVAKCPHCQKNSSIGPWYARIRWXXXXXXXXXXXXXXXXVTVGXXXXXXXXXXXXVAYVGLFLSGIILFVKGSFYCCMPISTIETSLS 804
            INC+VC+++I+LD K++  VVKC  CNEATPIK  P GKKYVRC CN LLICK +S R+GCPRP+C+ +INL      + ++    +Q  L  Q    RV C +C + F+     + +F  +AKCPHC+K SS+G    R R   Y+ +G+I I + +G+TVGT   S ++ + YV++   +L G+I  ++  ++  + +S  E   +
Sbjct:   56 INCRVCQSLINLDGKLHQHVVKCTVCNEATPIKTPPTGKKYVRCPCNCLLICKDTSRRIGCPRPNCRRIINLGPV---MLISEEQPAQPALPIQPEGTRVVCGHCGNTFL---WMELRFNTLAKCPHCKKISSVGSALPRRRCCAYVTIGMICIFIAVGLTVGTQDFSRRFHATYVSWAIAYLLGLICLIRACYWGAIRVSYPEHGFA 257
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Mouse
Match: Pip4p1 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 [Source:MGI Symbol;Acc:MGI:2448501])

HSP 1 Score: 125.176 bits (313), Expect = 1.404e-33
Identity = 84/198 (42.42%), Postives = 116/198 (58.59%), Query Frame = 1 
Query:  190 INCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQSVRVTCVNCSSAFIISVQKQKKFMVAKCPHCQKNSSIGPWYARIRWXXXXXXXXXXXXXXXXVTVGXXXXXXXXXXXXVAYVGLFLSGIILFVKGSFYCCMPIS 783
            I C+VC++ I+++ KM+  VVKC  CNEATPIK APPGKKYVRC CN LLICK +S R+ CPRP+CK +INL        V  G  S        VRV C +C + F+ +    +   +A+CPHC+K SSIG  Y R R I   +LGL+      G+  GT+  + QY   Y A+  + L  ++   +  ++ CM +S
Sbjct:   82 ITCRVCQSPINVEGKMHQHVVKCGVCNEATPIKNAPPGKKYVRCPCNCLLICKVTSQRIACPRPYCKRIINLGP------VHPGPLSPEP-QPMGVRVICGHCKNTFLWTEFTDR--TLARCPHCRKVSSIGRRYPRKRCICCFLLGLLLAVTATGLAFGTWKHAQQYGGIYAAWAFVILLAVLCLGRALYWACMKVS 270
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Mouse
Match: Pip4p1 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 [Source:MGI Symbol;Acc:MGI:2448501])

HSP 1 Score: 125.176 bits (313), Expect = 1.435e-33
Identity = 84/198 (42.42%), Postives = 116/198 (58.59%), Query Frame = 1 
Query:  190 INCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQSVRVTCVNCSSAFIISVQKQKKFMVAKCPHCQKNSSIGPWYARIRWXXXXXXXXXXXXXXXXVTVGXXXXXXXXXXXXVAYVGLFLSGIILFVKGSFYCCMPIS 783
            I C+VC++ I+++ KM+  VVKC  CNEATPIK APPGKKYVRC CN LLICK +S R+ CPRP+CK +INL        V  G  S        VRV C +C + F+ +    +   +A+CPHC+K SSIG  Y R R I   +LGL+      G+  GT+  + QY   Y A+  + L  ++   +  ++ CM +S
Sbjct:   89 ITCRVCQSPINVEGKMHQHVVKCGVCNEATPIKNAPPGKKYVRCPCNCLLICKVTSQRIACPRPYCKRIINLGP------VHPGPLSPEP-QPMGVRVICGHCKNTFLWTEFTDR--TLARCPHCRKVSSIGRRYPRKRCICCFLLGLLLAVTATGLAFGTWKHAQQYGGIYAAWAFVILLAVLCLGRALYWACMKVS 277
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Mouse
Match: Pip4p1 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 [Source:MGI Symbol;Acc:MGI:2448501])

HSP 1 Score: 107.457 bits (267), Expect = 7.054e-27
Identity = 56/109 (51.38%), Postives = 71/109 (65.14%), Query Frame = 1 
Query:  190 INCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQSVRVTCVNCSSAFII 516
            I C+VC++ I+++ KM+  VVKC  CNEATPIK APPGKKYVRC CN LLICK +S R+ CPRP+CK +INL        V  G  S        VRV C +C + F++
Sbjct:   89 ITCRVCQSPINVEGKMHQHVVKCGVCNEATPIKNAPPGKKYVRCPCNCLLICKVTSQRIACPRPYCKRIINLGP------VHPGPLSPEP-QPMGVRVICGHCKNTFLV 190
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Mouse
Match: Pip4p1 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 [Source:MGI Symbol;Acc:MGI:2448501])

HSP 1 Score: 94.7449 bits (234), Expect = 1.233e-22
Identity = 43/66 (65.15%), Postives = 53/66 (80.30%), Query Frame = 1 
Query:  190 INCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHC 387
            I C+VC++ I+++ KM+  VVKC  CNEATPIK APPGKKYVRC CN LLICK +S R+ CPRP+C
Sbjct:   82 ITCRVCQSPINVEGKMHQHVVKCGVCNEATPIKNAPPGKKYVRCPCNCLLICKVTSQRIACPRPYC 147
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. UniProt/SwissProt
Match: sp|Q3SZ48|PP4P2_BOVIN (Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase OS=Bos taurus OX=9913 GN=PIP4P2 PE=2 SV=1)

HSP 1 Score: 131.339 bits (329), Expect = 2.400e-35
Identity = 86/208 (41.35%), Postives = 131/208 (62.98%), Query Frame = 1 
Query:  190 INCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQ--SVRVTCVNCSSAFIISVQKQKKF-MVAKCPHCQKNSSIGPWYARIRWXXXXXXXXXXXXXXXXVTVGXXXXXXXXXXXXVAYVGLFLSGIILFVKGSFYCCMPISTIETSLS 804
            INC+VC+++I+LD K++  VVKC  CNEATPIK  P GKKYVRC CN LLICK +S R+GCPRP+C+ +INL      + V+    +Q  L  Q    RV C +C + F+     + +F  +AKCPHC+K SS+G    R R   Y+ +G++ I +GIG+TVGT   + ++ + YV++   +L G++  ++  ++  + +S  E S +
Sbjct:   56 INCRVCQSLINLDGKLHQHVVKCTVCNEATPIKNPPAGKKYVRCPCNCLLICKDTSRRIGCPRPNCRRIINLGPV---MLVSEEQPAQPALPVQPEGTRVVCGHCGNTFL---WMELRFNTLAKCPHCKKISSVGSALPRRRCCAYITIGMMCIFIGIGLTVGTQDFARRFHATYVSWAIAYLLGLVCLIRACYWGAIRVSYPEHSFA 257
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. UniProt/SwissProt
Match: sp|Q8N4L2|PP4P2_HUMAN (Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase OS=Homo sapiens OX=9606 GN=PIP4P2 PE=1 SV=1)

HSP 1 Score: 130.568 bits (327), Expect = 4.434e-35
Identity = 86/208 (41.35%), Postives = 132/208 (63.46%), Query Frame = 1 
Query:  190 INCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQ--SVRVTCVNCSSAFIISVQKQKKF-MVAKCPHCQKNSSIGPWYARIRWXXXXXXXXXXXXXXXXVTVGXXXXXXXXXXXXVAYVGLFLSGIILFVKGSFYCCMPISTIETSLS 804
            INC+VC+++I+LD K++  VVKC  CNEATPIK  P GKKYVRC CN LLICK +S R+GCPRP+C+ +INL      + ++    +Q  L  Q    RV C +C + F+     + +F  +AKCPHC+K SS+G    R R   Y+ +G+I I +G+G+TVGT   + ++++ YV++   +L G+I  ++  ++  + +S  E S +
Sbjct:   56 INCRVCQSLINLDGKLHQHVVKCTVCNEATPIKNPPTGKKYVRCPCNCLLICKDTSRRIGCPRPNCRRIINLGPV---MLISEEQPAQPALPIQPEGTRVVCGHCGNTFL---WMELRFNTLAKCPHCKKISSVGSALPRRRCCAYITIGMICIFIGVGLTVGTPDFARRFRATYVSWAIAYLLGLICLIRACYWGAIRVSYPEHSFA 257
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. UniProt/SwissProt
Match: sp|Q9CZX7|PP4P2_MOUSE (Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase OS=Mus musculus OX=10090 GN=Pip4p2 PE=1 SV=1)

HSP 1 Score: 129.798 bits (325), Expect = 9.598e-35
Identity = 85/208 (40.87%), Postives = 129/208 (62.02%), Query Frame = 1 
Query:  190 INCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQ--SVRVTCVNCSSAFIISVQKQKKF-MVAKCPHCQKNSSIGPWYARIRWXXXXXXXXXXXXXXXXVTVGXXXXXXXXXXXXVAYVGLFLSGIILFVKGSFYCCMPISTIETSLS 804
            INC+VC+++I+LD K++  VVKC  CNEATPIK  P GKKYVRC CN LLICK +S R+GCPRP+C+ +INL      + ++    +Q  L  Q    RV C +C + F+     + +F  +AKCPHC+K SS+G    R R   Y+ +G+I I + +G+TVGT   S ++ + YV++   +L G+I  ++  ++  + +S  E   +
Sbjct:   56 INCRVCQSLINLDGKLHQHVVKCTVCNEATPIKTPPTGKKYVRCPCNCLLICKDTSRRIGCPRPNCRRIINLGPV---MLISEEQPAQPALPIQPEGTRVVCGHCGNTFL---WMELRFNTLAKCPHCKKISSVGSALPRRRCCAYVTIGMICIFIAVGLTVGTQDFSRRFHATYVSWAIAYLLGLICLIRACYWGAIRVSYPEHGFA 257
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. UniProt/SwissProt
Match: sp|Q4V888|PP4P2_RAT (Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase OS=Rattus norvegicus OX=10116 GN=Pip4p2 PE=1 SV=1)

HSP 1 Score: 129.413 bits (324), Expect = 1.224e-34
Identity = 86/208 (41.35%), Postives = 130/208 (62.50%), Query Frame = 1 
Query:  190 INCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQ--SVRVTCVNCSSAFIISVQKQKKF-MVAKCPHCQKNSSIGPWYARIRWXXXXXXXXXXXXXXXXVTVGXXXXXXXXXXXXVAYVGLFLSGIILFVKGSFYCCMPISTIETSLS 804
            INC+VC+++I+LD K++  VVKC  CNEATPIK  P GKKYVRC CN LLICK +S R+GCPRP+C+ +INL      + ++    +Q  L  Q    RV C +C + F+     + +F  +AKCPHC+K SS+G    R R   Y+ +G+I I +G+G+TVGT   S ++ + YV++   +L G+I  ++  ++  + +S  E   +
Sbjct:   56 INCRVCQSLINLDGKLHQHVVKCTVCNEATPIKTPPTGKKYVRCPCNCLLICKDTSRRIGCPRPNCRRIINLGPI---MLISEEQPAQPALPVQPEGTRVVCGHCGNTFL---WMELRFNTLAKCPHCKKISSVGSALPRRRCCAYVTIGMICIFIGVGLTVGTQDFSRRFHATYVSWAIAYLLGLICLIRACYWGAIRVSYPEHGFA 257
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. UniProt/SwissProt
Match: sp|Q66I51|T55BB_DANRE (Type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase-B OS=Danio rerio OX=7955 GN=tmem55bb PE=2 SV=2)

HSP 1 Score: 129.413 bits (324), Expect = 1.383e-34
Identity = 99/251 (39.44%), Postives = 140/251 (55.78%), Query Frame = 1 
Query:   55 DIMSKEKLVDFEEIPEFSNPQNFQNTFVTIPL-----PDSQENGNTLTNS---INCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQSVRVTCVNCSSAFIISVQKQKKFMVAKCPHCQKNSSIGPWYARIRWXXXXXXXXXXXXXXXXVTVGXXXXXXXXXXXXVAYVGLFLSGIILFVKGSFYCCMPIS 783
            D M+   L D E     S PQNF       P+     P     G+  ++S   I+C+VC+++IS++ K++  VVKC  CNEATPIK AP GKKYVRC CN LLICK +S R+ CPRP+CK VINL       G  +     TG      RV+C +C+  F+ +    +   +A+CPHC+K SSIG  Y R R +I  +L LIF+    G+  GT+  + +YK  Y ++V   +  ++  V+   + CM IS
Sbjct:   15 DGMTGLSLGD-EPYRPISKPQNFAVFPSAPPMLGEAPPPYSPLGSPESSSAPVISCRVCQSLISVEGKIHQHVVKCGVCNEATPIKNAPAGKKYVRCPCNCLLICKVTSQRIACPRPYCKRVINLGPVNP--GAGSPNPQPTG-----ARVSCGHCAKTFLWTEFTDR--TLARCPHCRKVSSIGQRYPRKRSLICFLLCLIFVITTAGLIAGTWLKAQKYKGIYASWVFFIVLVLVTLVRALHWACMKIS 255
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. TrEMBL
Match: A0A1B6G0B3 (Phosphatidylinositol-4,5-bisphosphate 4-phosphatase (Fragment) OS=Cuerna arida OX=1464854 GN=g.40207 PE=4 SV=1)

HSP 1 Score: 159.458 bits (402), Expect = 3.279e-44
Identity = 99/218 (45.41%), Postives = 135/218 (61.93%), Query Frame = 1 
Query:  148 LPDSQENGNTLTNSINCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQSVRVTCVNCSSAFIISVQKQKKFMVAKCPHCQKNSSIGPWYARIRWXXXXXXXXXXXXXXXXVTVGXXXXXXXXXXXXVAYVGLFLSGIILFVKGSFYCCMPISTIETSL 801
            LP   +        + C+VC+ +I +  K +  VVKCN CNEATPI+ APPGKKYVRC CN LLICKSSS R+ CPRP+CK +INLA +     V   V +Q GL     RV+CV+C   F+ +        +A+CPHC+K SS+GP +AR R I ++I G I + L IGVT G+Y  +     YYVAYVG F+  ++ F + ++YC M +S I+  +
Sbjct:   12 LPPPYQAALQGGPMVTCRVCQAMIDVSGKKDQHVVKCNTCNEATPIRNAPPGKKYVRCPCNCLLICKSSSQRIACPRPNCKRIINLAPSP----VTPPVPNQPGL----CRVSCVHCHDTFLFNTLTNA---LARCPHCRKVSSVGPDFARGRGIFFIIGGTIMLLLAIGVTAGSYAYALHNGGYYVAYVGAFIIALLCFFRSAYYCTMKVSVIDGPM 218
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. TrEMBL
Match: A0A1B6IFY4 (Phosphatidylinositol-4,5-bisphosphate 4-phosphatase OS=Homalodisca liturata OX=320908 GN=g.28620 PE=4 SV=1)

HSP 1 Score: 160.229 bits (404), Expect = 4.438e-44
Identity = 97/204 (47.55%), Postives = 132/204 (64.71%), Query Frame = 1 
Query:  190 INCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQSVRVTCVNCSSAFIISVQKQKKFMVAKCPHCQKNSSIGPWYARIRWXXXXXXXXXXXXXXXXVTVGXXXXXXXXXXXXVAYVGLFLSGIILFVKGSFYCCMPISTIETSL 801
            + C+VC+ +I +  K +  VVKCN CNEATPI+ APPGKKYVRC CN LLICKSSS R+ CPRP+CK +INLA +     V   V +Q GL     RV+CV+C   F+ +        +A+CPHC+K SS+GP +AR R I ++I G I + L IGVT G+Y  +     YYVAYVG F+  ++ F + ++YC M +S I+  +
Sbjct:   61 VTCRVCQAMIDVSGKKDQHVVKCNTCNEATPIRNAPPGKKYVRCPCNCLLICKSSSQRIACPRPNCKRIINLAPSP----VTPPVPNQPGL----CRVSCVHCHDTFLFNTLTNA---LARCPHCRKVSSVGPDFARGRGIFFIIGGTIMLLLAIGVTAGSYAYALHNGGYYVAYVGAFIIALLCFFRSAYYCTMKVSVIDGPM 253
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. TrEMBL
Match: R7TMJ2 (Phosphatidylinositol-4,5-bisphosphate 4-phosphatase OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_225202 PE=4 SV=1)

HSP 1 Score: 160.229 bits (404), Expect = 5.463e-44
Identity = 94/201 (46.77%), Postives = 130/201 (64.68%), Query Frame = 1 
Query:  190 INCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQSVRVTCVNCSSAFIISVQKQKKFMVAKCPHCQKNSSIGPWYARIRWXXXXXXXXXXXXXXXXVTVGXXXXXXXXXXXXVAYVGLFLSGIILFVKGSFYCCMPISTIE 792
            INC+VC+++I++D K +  VVKCN CNEATPIKAAPPGKKYVRC CN LLICK SS R+ CPRP+CK +INL      + +     S         RV C +C   F+ ++  +    +A+CPHC++ SS+G  YAR R I +  +G++F +LGIG+TVGT   + ++    V Y G F+ GIIL +K  +Y  M +S+IE
Sbjct:   66 INCKVCQSMINIDGKTHQHVVKCNLCNEATPIKAAPPGKKYVRCPCNCLLICKGSSQRIACPRPNCKRIINLGPAAAAVSMRPPGMS---------RVLCAHCGDTFLFNIMNKA---LARCPHCRRVSSVGVQYARRRAIFFACVGVMFFALGIGITVGTSMYANKHGGIIVVYCGAFIFGIILLIKAIYYAAMKVSSIE 254
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. TrEMBL
Match: A0A1B6M4A9 (Phosphatidylinositol-4,5-bisphosphate 4-phosphatase OS=Graphocephala atropunctata OX=36148 GN=g.31916 PE=4 SV=1)

HSP 1 Score: 159.458 bits (402), Expect = 1.058e-43
Identity = 97/204 (47.55%), Postives = 131/204 (64.22%), Query Frame = 1 
Query:  190 INCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQSVRVTCVNCSSAFIISVQKQKKFMVAKCPHCQKNSSIGPWYARIRWXXXXXXXXXXXXXXXXVTVGXXXXXXXXXXXXVAYVGLFLSGIILFVKGSFYCCMPISTIETSL 801
            + C+VC+ +I +  K +  VVKCN CNEATPI+ APPGKKYVRC CN LLICKSSS R+ CPRP+CK +INLA +     V   V +Q GL     RV CV+C   F+ +        +A+CPHC+K SS+GP +AR R I ++I G I + L IGVT G+Y  +     YYVAYVG F+  ++ F + ++YC M +S I+  +
Sbjct:   61 VTCRVCQAMIDVSGKKDQHVVKCNTCNEATPIRNAPPGKKYVRCPCNCLLICKSSSQRIACPRPNCKRIINLAPSP----VTPPVPNQPGL----CRVGCVHCHDTFLFNTLTNA---LARCPHCRKVSSVGPDFARGRGIFFIIGGTIMLLLAIGVTAGSYAYALHNGGYYVAYVGAFIIALLCFFRSAYYCTMKVSVIDGPM 253
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. TrEMBL
Match: A0A1D2MC84 (Phosphatidylinositol-4,5-bisphosphate 4-phosphatase OS=Orchesella cincta OX=48709 GN=Ocin01_16129 PE=4 SV=1)

HSP 1 Score: 155.992 bits (393), Expect = 1.326e-42
Identity = 93/201 (46.27%), Postives = 128/201 (63.68%), Query Frame = 1 
Query:  190 INCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQSVRVTCVNCSSAFIISVQKQKKFMVAKCPHCQKNSSIGPWYARIRWXXXXXXXXXXXXXXXXVTVGXXXXXXXXXXXXVAYVGLFLSGIILFVKGSFYCCMPISTIE 792
            + C+VC+  I +  K    VVKC +C+EATPI+  PPGKKYVRC CN LLIC++SS R+ CPRP+CK +INLA +     V  G+           RV C +C+ +F+ +        +A+CPHC+K SS+GP +AR R I +L+L  IF+ +GIGVTVGTY  + +    +VAY+G FL  +  FV+  +YC M ISTIE
Sbjct:   48 VTCRVCQASIDITDKREQHVVKCGSCSEATPIRNPPPGKKYVRCPCNCLLICRASSQRIACPRPNCKRIINLAPSPALPAVPLGMA----------RVNCAHCADSFLFNTLNNS---LARCPHCRKLSSVGPDFARSRGIFHLVLAFIFLLIGIGVTVGTYQVATRKGGLFVAYLGAFLVALFFFVRTIYYCTMKISTIE 235
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Cavefish
Match: ENSAMXT00000052119.1 (type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase-B-like [Source:NCBI gene;Acc:103040625])

HSP 1 Score: 128.257 bits (321), Expect = 3.412e-35
Identity = 68/139 (48.92%), Postives = 89/139 (64.03%), Query Frame = 1 
Query:  190 INCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQSVRVTCVNCSSAFIISVQKQKKFMVAKCPHCQKNSSIGPWYARIR 606
            I+C+VC+++IS++ KM+  VVKC  CNEATPIK AP GKKYVRC CN LLICK SS ++ CPRP+CK VINL      +G     T          RV+C +C + F+ +    +   +A+CPHC+K SSIG  Y R R
Sbjct:   60 ISCRVCQSLISVEGKMHQHVVKCGVCNEATPIKNAPAGKKYVRCPCNCLLICKVSSQKIACPRPYCKRVINLGPVHPAVGSPAHPT--------GARVSCGHCGNTFLWTEFTNR--TLARCPHCRKVSSIGQRYPRRR 188
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Cavefish
Match: pip4p2 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 [Source:NCBI gene;Acc:103040016])

HSP 1 Score: 127.102 bits (318), Expect = 1.920e-34
Identity = 90/227 (39.65%), Postives = 134/227 (59.03%), Query Frame = 1 
Query:  190 INCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQ--SVRVTCVNCSSAFIISVQKQK--------------KFM------VAKCPHCQKNSSIGPWYARIRWXXXXXXXXXXXXXXXXVTVGXXXXXXXXXXXXVAYVGLFLSGIILFVKGSFYCCMPISTIETSLS 804
            INC+VC+++I+LD K++  VVKC  CNEATPIK  P GKKYVRC CN LLICK +S R+GCPRP+C+ +INL+     + +     +Q  L  Q   +RV C +C + F+ S    +              K+M      +AKCPHC+K SS+G    R R   Y+ +G+I I +GIG+TVGT   + +Y + YV++   +L G+I  V+  ++  + +S  E + +
Sbjct:   58 INCRVCQSLINLDGKLHQHVVKCTVCNEATPIKNPPTGKKYVRCPCNCLLICKDTSRRIGCPRPNCRRIINLSPV---MVIPEEQPAQPALPVQPEGMRVVCGHCGNTFLGSDAASQSASGLRIDGASAPFKWMELRFNTLAKCPHCKKISSVGSALPRRRCCAYITVGMICIFIGIGLTVGTQDFASRYHATYVSWAFAYLLGLICLVRACYWGAIKVSYPENTFA 281
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Cavefish
Match: pip4p1a (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 [Source:NCBI gene;Acc:103033991])

HSP 1 Score: 125.946 bits (315), Expect = 4.140e-34
Identity = 72/150 (48.00%), Postives = 97/150 (64.67%), Query Frame = 1 
Query:  157 SQENGNTLTNSINCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQSVRVTCVNCSSAFIISVQKQKKFMVAKCPHCQKNSSIGPWYARIR 606
            S E+G+     I+C+VC+++IS++ K++  VVKC  CNEATPIK AP GKKYVRC CN LLICK +S R+ CPRP+CK +INL       G A+     TG      RV+C +CS+ F+ +    +   +A+CPHC+K SSIG  Y R R
Sbjct:   67 SPESGSAPV--ISCRVCQSLISVEGKIHQHVVKCGVCNEATPIKNAPAGKKYVRCPCNCLLICKVTSQRIACPRPYCKRIINLGPV--HPGPASPDPQPTG-----ARVSCGHCSNTFLWTEFTDR--TLARCPHCRKVSSIGQRYPRRR 205
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Cavefish
Match: pip4p2 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 [Source:NCBI gene;Acc:103040016])

HSP 1 Score: 124.405 bits (311), Expect = 3.233e-33
Identity = 68/142 (47.89%), Postives = 93/142 (65.49%), Query Frame = 1 
Query:  190 INCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQ--SVRVTCVNCSSAFIISVQKQKKF-MVAKCPHCQKNSSIGPWYARIR 606
            INC+VC+++I+LD K++  VVKC  CNEATPIK  P GKKYVRC CN LLICK +S R+GCPRP+C+ +INL+     + +     +Q  L  Q   +RV C +C + F+     + +F  +AKCPHC+K SS+G    R R
Sbjct:   58 INCRVCQSLINLDGKLHQHVVKCTVCNEATPIKNPPTGKKYVRCPCNCLLICKDTSRRIGCPRPNCRRIINLSPV---MVIPEEQPAQPALPVQPEGMRVVCGHCGNTFL---WMELRFNTLAKCPHCKKISSVGSALPRRR 193
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Cavefish
Match: ENSAMXT00000050101.1 (type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase-B-like [Source:NCBI gene;Acc:103040625])

HSP 1 Score: 118.627 bits (296), Expect = 2.202e-31
Identity = 65/153 (42.48%), Postives = 89/153 (58.17%), Query Frame = 1 
Query:  112 PQNFQNTFVTIPLPDSQENGNTLTNSINCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQSVRVTCVNCSSAFIISVQKQKKFMVAKCPHCQK 570
            P      +  +  PDS       +  I+C+VC+++IS++ KM+  VVKC  CNEATPIK AP GKKYVRC CN LLICK SS ++ CPRP+CK VINL      +G     T          RV+C +C + F+ +    +   +A+CPHC+K
Sbjct:   57 PGEAPPPYSPLASPDSSS-----SPVISCRVCQSLISVEGKMHQHVVKCGVCNEATPIKNAPAGKKYVRCPCNCLLICKVSSQKIACPRPYCKRVINLGPVHPAVGSPAHPT--------GARVSCGHCGNTFLWTEFTNR--TLARCPHCRK 194
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Nematostella
Match: EDO49196 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RHB1])

HSP 1 Score: 147.902 bits (372), Expect = 1.304e-43
Identity = 85/221 (38.46%), Postives = 132/221 (59.73%), Query Frame = 1 
Query:  142 IPLPDSQENGNT-LTNSINCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQSVRVTCVNCSSAFIISVQKQKKFMVAKCPHCQKNSSIGPWYARIRWXXXXXXXXXXXXXXXXVTVGXXXXXXXXXXXXVAYVGLFLSGIILFVKGSFYCCMPISTIETSL 801
            +P P S   G      S+ C+VC+ +I +  + +  VVKC+NC EATPIK  P GKKY+RC CN LL CK +S+R+ CPRP+CK +INLA     +       +  G      RV C +C+  F+          +A+CPHC++ SS+GP +A+ R  I+ ++G +F++ G+GVTVGT   + +    YV ++G F++GI+  ++  +YC M +S+IE  +
Sbjct:    2 MPPPYSPSTGAMNAEPSVICRVCQQIIYIRGREHQRVVKCSNCQEATPIKPPPSGKKYIRCPCNALLTCKVTSTRISCPRPNCKRIINLATQPSTLPTVDATPNARGRF----RVNCGHCNEVFVFHTTSH----LARCPHCRRVSSVGPSFAKTRATIFAVVGFLFLAAGVGVTVGTLEYAEKSGGIYVVWIGAFVAGILNLIRSCYYCTMTVSSIEEEV 214
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Medaka
Match: pip4p2 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 [Source:NCBI gene;Acc:101166147])

HSP 1 Score: 131.724 bits (330), Expect = 1.869e-36
Identity = 87/208 (41.83%), Postives = 132/208 (63.46%), Query Frame = 1 
Query:  190 INCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQ--SVRVTCVNCSSAFIISVQKQKKF-MVAKCPHCQKNSSIGPWYARIRWXXXXXXXXXXXXXXXXVTVGXXXXXXXXXXXXVAYVGLFLSGIILFVKGSFYCCMPISTIETSLS 804
            INC+VC+++I+LD K++  VVKC  CNEATPIK  P GKKYVRC CN LLICK +S R+GCPRP+C+ +INL+     + +     +Q  L  Q   +RV C +C + F+     + +F  +AKCPHC+K SS+G    R R   Y+ +G+I I +G+G+TVGT   + +Y + YV++   +L G+I  ++  ++  + +S  E S +
Sbjct:   56 INCRVCQSLINLDGKLHQHVVKCTVCNEATPIKNPPTGKKYVRCPCNCLLICKDTSRRIGCPRPNCRRIINLSPV---MVIPEEQPAQPALPIQPEGMRVVCGHCGNTFL---WMELRFNTLAKCPHCKKISSVGSALPRRRCCAYITVGMICIFIGVGLTVGTRGFARRYNATYVSWAFAYLLGLICLIRACYWGAIKVSYPENSFA 257
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Medaka
Match: pip4p2 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 [Source:NCBI gene;Acc:101166147])

HSP 1 Score: 127.487 bits (319), Expect = 1.565e-34
Identity = 89/230 (38.70%), Postives = 135/230 (58.70%), Query Frame = 1 
Query:  190 INCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQ--SVRVTCVNCSSAFIISVQ-----------------KQKKFM------VAKCPHCQKNSSIGPWYARIRWXXXXXXXXXXXXXXXXVTVGXXXXXXXXXXXXVAYVGLFLSGIILFVKGSFYCCMPISTIETSLS 804
            INC+VC+++I+LD K++  VVKC  CNEATPIK  P GKKYVRC CN LLICK +S R+GCPRP+C+ +INL+     + +     +Q  L  Q   +RV C +C + F+ S                    Q+++M      +AKCPHC+K SS+G    R R   Y+ +G+I I +G+G+TVGT   + +Y + YV++   +L G+I  ++  ++  + +S  E S +
Sbjct:   56 INCRVCQSLINLDGKLHQHVVKCTVCNEATPIKNPPTGKKYVRCPCNCLLICKDTSRRIGCPRPNCRRIINLSPV---MVIPEEQPAQPALPIQPEGMRVVCGHCGNTFLGSEDARSSQPMSGLSRDGSPPAQQQWMELRFNTLAKCPHCKKISSVGSALPRRRCCAYITVGMICIFIGVGLTVGTRGFARRYNATYVSWAFAYLLGLICLIRACYWGAIKVSYPENSFA 282
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Medaka
Match: pip4p1a (type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase-A [Source:NCBI gene;Acc:101161334])

HSP 1 Score: 125.176 bits (313), Expect = 1.744e-33
Identity = 71/150 (47.33%), Postives = 96/150 (64.00%), Query Frame = 1 
Query:  157 SQENGNTLTNSINCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQSVRVTCVNCSSAFIISVQKQKKFMVAKCPHCQKNSSIGPWYARIR 606
            S E+G+     I+C+VC+++IS++ K++  VVKC  CNEATPIK AP GKKYVRC CN LLICK +S R+ CPRP+CK +INL       G A+      G      RV+C +CS+ F+ +    +   +A+CPHC+K SSIG  Y R R
Sbjct:   92 SPESGSAPV--ISCRVCQSLISVEGKIHQHVVKCGVCNEATPIKNAPAGKKYVRCPCNCLLICKVTSQRIACPRPYCKRIINLGPV--HPGPASPDPQPAG-----ARVSCGHCSNTFLWTEFTDR--TLARCPHCRKVSSIGQRYPRRR 230
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Medaka
Match: pip4p2 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 [Source:NCBI gene;Acc:101166147])

HSP 1 Score: 124.79 bits (312), Expect = 2.471e-33
Identity = 86/217 (39.63%), Postives = 129/217 (59.45%), Query Frame = 1 
Query:  190 INCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQ--SVRVTCVNCSSAFIISVQ-----------------KQKKFM------VAKCPHCQKNSSIGPWYARIRWXXXXXXXXXXXXXXXXVTVGXXXXXXXXXXXXVAYVGLFLSGIILFVKGSFY 765
            INC+VC+++I+LD K++  VVKC  CNEATPIK  P GKKYVRC CN LLICK +S R+GCPRP+C+ +INL+     + +     +Q  L  Q   +RV C +C + F+ S                    Q+++M      +AKCPHC+K SS+G    R R   Y+ +G+I I +G+G+TVGT   + +Y + YV++   +L G+I  ++  ++
Sbjct:   56 INCRVCQSLINLDGKLHQHVVKCTVCNEATPIKNPPTGKKYVRCPCNCLLICKDTSRRIGCPRPNCRRIINLSPV---MVIPEEQPAQPALPIQPEGMRVVCGHCGNTFLGSEDARSSQPMSGLSRDGSPPAQQQWMELRFNTLAKCPHCKKISSVGSALPRRRCCAYITVGMICIFIGVGLTVGTRGFARRYNATYVSWAFAYLLGLICLIRACYW 269
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Medaka
Match: pip4p1b (type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase-B [Source:NCBI gene;Acc:101159467])

HSP 1 Score: 118.627 bits (296), Expect = 1.889e-31
Identity = 75/181 (41.44%), Postives = 106/181 (58.56%), Query Frame = 1 
Query:   88 EEIPEF-SNPQN---FQNTFVT-IPLPDSQENGNTLTNS---INCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQSVRVTCVNCSSAFIISVQKQKKFMVAKCPHCQKNSSIGPWYARIR 606
            E  P F S PQ+   F ++ V+  P P     G+  + S   ++C+VC++ IS++ K +  VVKCN C+EATPIK AP GKKYVRC CN LLICK +S ++ CPR +CK +INL      +G  +       +    +RVTC +C   F+ +    +   +A+CPHC+K SSIG  Y R R
Sbjct:   24 EMSPGFLSKPQSLAPFPSSVVSGEPPPPYSPQGSPDSGSAAFVSCRVCQSAISVEGKAHQHVVKCNICSEATPIKNAPVGKKYVRCPCNCLLICKVTSQKIACPRTYCKRIINLGPV--HVGTDSPEPQHQPV---GIRVTCGHCYHPFLWTEFSDR--TLARCPHCRKVSSIGRRYPRRR 197
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Planmine SMEST
Match: SMESG000063221.1 (SMESG000063221.1)

HSP 1 Score: 446.817 bits (1148), Expect = 2.569e-160
Identity = 250/251 (99.60%), Postives = 251/251 (100.00%), Query Frame = 1 
Query:   61 MSKEKLVDFEEIPEFSNPQNFQNTFVTIPLPDSQENGNTLTNSINCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQSVRVTCVNCSSAFIISVQKQKKFMVAKCPHCQKNSSIGPWYARIRWXXXXXXXXXXXXXXXXVTVGXXXXXXXXXXXXVAYVGLFLSGIILFVKGSFYCCMPISTIETSLSPRI 813
            MSKEKLVDFEEIPEFSNPQNFQN+FVTIPLPDSQENGNTLTNSINCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQSVRVTCVNCSSAFIISVQKQKKFMVAKCPHCQKNSSIGPWYARIRWIIYLILGLIFISLGIGVTVGTYTSSYQYKSYYVAYVGLFLSGIILFVKGSFYCCMPISTIETSLSPRI
Sbjct:    1 MSKEKLVDFEEIPEFSNPQNFQNSFVTIPLPDSQENGNTLTNSINCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQSVRVTCVNCSSAFIISVQKQKKFMVAKCPHCQKNSSIGPWYARIRWIIYLILGLIFISLGIGVTVGTYTSSYQYKSYYVAYVGLFLSGIILFVKGSFYCCMPISTIETSLSPRI 251
[Close]
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Planmine SMEST
Match: SMESG000025924.1 (SMESG000025924.1)

HSP 1 Score: 87.4261 bits (215), Expect = 1.134e-19
Identity = 69/278 (24.82%), Postives = 118/278 (42.45%), Query Frame = 1 
Query:  115 QNFQNTFVTIPLPDSQE--NGNTLTNSINCQVCRNVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSSRVGCPRPHCKAVI----------------------------------------------NLAATT-----DEIGVATGVTSQTGLLAQSVRVTCVNCSSAFIISVQKQKKFMVAKCPHCQKNSSIGPWYARIRWXXXXXXXXXXXXXXXXVTVGXXXXXXXXXXXXVAYVGLFLSGIILFVKGSFYCCMPISTI 789
            QN  +  +  P+  SQ   +  T+  S+ CQVC N+I +    N + V+C+ C+EATPIK  P G+ + RC C+ LLI + +SS+V C R  C  ++                                              NL++ T     +E+G           + + + + C  C   F+I  ++      A+CPHC   +S+G  +AR +WI+ L    +   L    ++ +   +    +  V  +G     I L ++  +YC MP+ST+
Sbjct:   17 QNGMDEIIYSPVHPSQPIYSPGTIFKSVICQVCLNIIEISGLQNQIAVQCSFCHEATPIKNPPAGQHFFRCPCDCLLIVRVTSSQVVCSRRRCGKLLKLSNGNIDSVFKTKVDTVREVTFENRPPTFSDKTTENTSTMEKKRSNLSSGTNRFDDNELGRRISTIGMKHNVTKGIIIKCGKCGLRFVI--EELAYNTAARCPHCMSETSVGVKFARRKWILLLAFAAMLWFLLCVPSIYSIVRTNANGNIKVISLGPLFIVIALLLRACYYCLMPVSTV 292
The following BLAST results are available for this feature:
BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
PIP4P29.234e-3641.35phosphatidylinositol-4,5-bisphosphate 4-phosphatas... [more]
PIP4P25.103e-3542.56phosphatidylinositol-4,5-bisphosphate 4-phosphatas... [more]
PIP4P17.456e-3441.92phosphatidylinositol-4,5-bisphosphate 4-phosphatas... [more]
PIP4P17.709e-3441.92phosphatidylinositol-4,5-bisphosphate 4-phosphatas... [more]
PIP4P23.543e-2849.55phosphatidylinositol-4,5-bisphosphate 4-phosphatas... [more]
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BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
Y71H2AM.21.169e-3144.93Phosphatidylinositol-4,5-bisphosphate 4-phosphatas... [more]
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BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3
Match NameE-valueIdentityDescription
CG67072.013e-3840.00gene:FBgn0036058 transcript:FBtr0076358[more]
CG67075.464e-3840.00gene:FBgn0036058 transcript:FBtr0076357[more]
CG67075.464e-3840.00gene:FBgn0036058 transcript:FBtr0076356[more]
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BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
pip4p21.531e-3642.31phosphatidylinositol-4,5-bisphosphate 4-phosphatas... [more]
pip4p21.531e-3642.31phosphatidylinositol-4,5-bisphosphate 4-phosphatas... [more]
pip4p1b1.832e-3539.44phosphatidylinositol-4,5-bisphosphate 4-phosphatas... [more]
pip4p1a2.789e-3441.94phosphatidylinositol-4,5-bisphosphate 4-phosphatas... [more]
pip4p1a2.789e-3441.94phosphatidylinositol-4,5-bisphosphate 4-phosphatas... [more]
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BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 3
Match NameE-valueIdentityDescription
pip4p23.785e-3540.87phosphatidylinositol-4,5-bisphosphate 4-phosphatas... [more]
pip4p12.465e-3146.67phosphatidylinositol-4,5-bisphosphate 4-phosphatas... [more]
pip4p29.071e-3137.28phosphatidylinositol-4,5-bisphosphate 4-phosphatas... [more]
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BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Pip4p21.372e-3540.87phosphatidylinositol-4,5-bisphosphate 4-phosphatas... [more]
Pip4p11.404e-3342.42phosphatidylinositol-4,5-bisphosphate 4-phosphatas... [more]
Pip4p11.435e-3342.42phosphatidylinositol-4,5-bisphosphate 4-phosphatas... [more]
Pip4p17.054e-2751.38phosphatidylinositol-4,5-bisphosphate 4-phosphatas... [more]
Pip4p11.233e-2265.15phosphatidylinositol-4,5-bisphosphate 4-phosphatas... [more]
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BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q3SZ48|PP4P2_BOVIN2.400e-3541.35Type 2 phosphatidylinositol 4,5-bisphosphate 4-pho... [more]
sp|Q8N4L2|PP4P2_HUMAN4.434e-3541.35Type 2 phosphatidylinositol 4,5-bisphosphate 4-pho... [more]
sp|Q9CZX7|PP4P2_MOUSE9.598e-3540.87Type 2 phosphatidylinositol 4,5-bisphosphate 4-pho... [more]
sp|Q4V888|PP4P2_RAT1.224e-3441.35Type 2 phosphatidylinositol 4,5-bisphosphate 4-pho... [more]
sp|Q66I51|T55BB_DANRE1.383e-3439.44Type I phosphatidylinositol 4,5-bisphosphate 4-pho... [more]
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BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1B6G0B33.279e-4445.41Phosphatidylinositol-4,5-bisphosphate 4-phosphatas... [more]
A0A1B6IFY44.438e-4447.55Phosphatidylinositol-4,5-bisphosphate 4-phosphatas... [more]
R7TMJ25.463e-4446.77Phosphatidylinositol-4,5-bisphosphate 4-phosphatas... [more]
A0A1B6M4A91.058e-4347.55Phosphatidylinositol-4,5-bisphosphate 4-phosphatas... [more]
A0A1D2MC841.326e-4246.27Phosphatidylinositol-4,5-bisphosphate 4-phosphatas... [more]
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BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSAMXT00000052119.13.412e-3548.92type I phosphatidylinositol 4,5-bisphosphate 4-pho... [more]
pip4p21.920e-3439.65phosphatidylinositol-4,5-bisphosphate 4-phosphatas... [more]
pip4p1a4.140e-3448.00phosphatidylinositol-4,5-bisphosphate 4-phosphatas... [more]
pip4p23.233e-3347.89phosphatidylinositol-4,5-bisphosphate 4-phosphatas... [more]
ENSAMXT00000050101.12.202e-3142.48type I phosphatidylinositol 4,5-bisphosphate 4-pho... [more]
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BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO491961.304e-4338.46Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
pip4p21.869e-3641.83phosphatidylinositol-4,5-bisphosphate 4-phosphatas... [more]
pip4p21.565e-3438.70phosphatidylinositol-4,5-bisphosphate 4-phosphatas... [more]
pip4p1a1.744e-3347.33type I phosphatidylinositol 4,5-bisphosphate 4-pho... [more]
pip4p22.471e-3339.63phosphatidylinositol-4,5-bisphosphate 4-phosphatas... [more]
pip4p1b1.889e-3141.44type I phosphatidylinositol 4,5-bisphosphate 4-pho... [more]
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BLAST of Phosphatidylinositol-4,5-bisphosphate 4-phosphatase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000063221.12.569e-16099.60SMESG000063221.1[more]
SMESG000025924.11.134e-1924.82SMESG000025924.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30033014 ID=SMED30033014|Name=Phosphatidylinositol-4,5-bisphosphate 4-phosphatase|organism=Schmidtea mediterranea sexual|type=transcript|length=900bp
GGCGAATTTTTAAAACAGTTCAAAATTCCTAAAAATATAAAATTAATTAA
TTAAGATATAATGTCTAAAGAAAAGTTAGTTGATTTCGAAGAAATTCCAG
AATTTTCAAATCCACAAAACTTTCAAAACACATTTGTCACTATTCCTCTG
CCTGATTCACAGGAAAATGGTAACACTCTTACAAACAGCATTAATTGTCA
AGTTTGTAGAAATGTCATAAGTTTGGATCAAAAAATGAATAATCTTGTTG
TTAAATGTAATAACTGTAATGAAGCAACTCCTATAAAAGCCGCTCCGCCC
GGTAAGAAATATGTTCGATGTACATGTAATGGATTGTTAATCTGCAAATC
AAGCTCATCCAGAGTAGGATGCCCGCGACCTCATTGCAAAGCTGTCATTA
ATCTAGCAGCGACAACTGATGAAATTGGCGTTGCTACCGGTGTTACTAGT
CAAACAGGATTATTAGCTCAATCTGTCCGAGTTACTTGTGTCAATTGCAG
TAGTGCATTTATAATCAGTGTCCAGAAACAAAAGAAATTTATGGTAGCAA
AATGTCCACACTGTCAGAAAAATAGCAGTATCGGTCCTTGGTATGCTCGT
ATAAGATGGATAATTTATTTGATTTTGGGATTAATATTCATTAGTCTCGG
TATTGGAGTAACGGTTGGTACTTATACCTCCAGTTATCAATATAAAAGTT
ATTATGTTGCATATGTTGGTTTGTTTCTAAGTGGAATTATACTATTTGTC
AAAGGATCATTTTATTGCTGCATGCCCATAAGCACAATTGAGACCTCATT
ATCACCCAGAATCTGATTGACATCGAAGGACAACAAAAATAATTTTTTAA
TCATTAATGATTATTTTAATTAATAAAAAAGTTGTGAATTTCAAAAAAAA
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protein sequence of SMED30033014-orf-1

>SMED30033014-orf-1 ID=SMED30033014-orf-1|Name=SMED30033014-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=252bp
MSKEKLVDFEEIPEFSNPQNFQNTFVTIPLPDSQENGNTLTNSINCQVCR
NVISLDQKMNNLVVKCNNCNEATPIKAAPPGKKYVRCTCNGLLICKSSSS
RVGCPRPHCKAVINLAATTDEIGVATGVTSQTGLLAQSVRVTCVNCSSAF
IISVQKQKKFMVAKCPHCQKNSSIGPWYARIRWIIYLILGLIFISLGIGV
TVGTYTSSYQYKSYYVAYVGLFLSGIILFVKGSFYCCMPISTIETSLSPR
I*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: cellular component
TermDefinition
GO:0005764lysosome
GO:0005765lysosomal membrane
GO:0005768endosome
GO:0031902late endosome membrane
GO:0016020membrane
GO:0016021integral component of membrane
Vocabulary: molecular function
TermDefinition
GO:0016787hydrolase activity
GO:0034597phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000026gut
PLANA:0000070intestinal phagocyte
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR019178PtdIns-P2-Ptase
Vocabulary: biological process
TermDefinition
GO:0046856phosphatidylinositol dephosphorylation
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR019178Phosphatidylinositol 4,5-bisphosphate 4-phosphatasePFAMPF09788Tmemb_55Acoord: 36..241
e-value: 6.0E-66
score: 222.0
IPR019178Phosphatidylinositol 4,5-bisphosphate 4-phosphatasePANTHERPTHR21014UNCHARACTERIZEDcoord: 34..246
NoneNo IPR availablePANTHERPTHR21014:SF6PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 4-PHOSPHATASEcoord: 34..246
NoneNo IPR availableTMHMMTMhelixcoord: 215..237
NoneNo IPR availableTMHMMTMhelixcoord: 183..205