slc6a-8
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30032979 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 12
Homology
BLAST of slc6a-8 vs. Ensembl Human
Match: ARRB1 (arrestin beta 1 [Source:HGNC Symbol;Acc:HGNC:711]) HSP 1 Score: 476.093 bits (1224), Expect = 1.369e-155 Identity = 253/449 (56.35%), Postives = 314/449 (69.93%), Query Frame = 3
Query: 156 SKVFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFGTSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRLTG 1502
++VFKK+SPNGK+T YLGKRDF+D++D VDPVDGVVL+DP+YLK+R+V+V + AFRYGREDLDVLGLTFRKDL++A+ Q +PP + DK P LTRLQERLIKKLG +AYPF FE+P N P SVTLQPGP D GK CGVDYE+K + A+N +EK HKRNSV+L IRK+ YAP++P PQP+AE + F+MS L LEASLDKE YYHGE ISVNV V NN+NKT+KKIKI+VRQ+ADICL+N YKC V E +D + + +CKVY + P L+NNR+KRGLALDGKLKHEDTNLASST++ E N+E LGIIV YKVKV+LV+ G D+++ELPFTL HPKP +E P H + ++P +D +LI+LDT+ DDD++FEDFAR RL G
Sbjct: 6 TRVFKKASPNGKLTVYLGKRDFVDHIDLVDPVDGVVLVDPEYLKERRVYVTLTCAFRYGREDLDVLGLTFRKDLFVANVQSFPPAPE---DKKP------LTRLQERLIKKLGEHAYPFTFEIPPNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGPQPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAMEEADD---TVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLVVSRG-GDVAVELPFTLMHPKPKEEPP----------HREVPENETP--------------------------VDTNLIELDTN---------------DDDIVFEDFARQRLKG 390
BLAST of slc6a-8 vs. Ensembl Human
Match: ARRB1 (arrestin beta 1 [Source:HGNC Symbol;Acc:HGNC:711]) HSP 1 Score: 475.707 bits (1223), Expect = 2.234e-155 Identity = 254/456 (55.70%), Postives = 316/456 (69.30%), Query Frame = 3
Query: 156 SKVFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFG-------TSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRLTG 1502
++VFKK+SPNGK+T YLGKRDF+D++D VDPVDGVVL+DP+YLK+R+V+V + AFRYGREDLDVLGLTFRKDL++A+ Q +PP + DK P LTRLQERLIKKLG +AYPF FE+P N P SVTLQPGP D GK CGVDYE+K + A+N +EK HKRNSV+L IRK+ YAP++P PQP+AE + F+MS L LEASLDKE YYHGE ISVNV V NN+NKT+KKIKI+VRQ+ADICL+N YKC V E +D + + +CKVY + P L+NNR+KRGLALDGKLKHEDTNLASST++ E N+E LGIIV YKVKV+LV+ G +SD+++ELPFTL HPKP +E P H + ++P +D +LI+LDT+ DDD++FEDFAR RL G
Sbjct: 6 TRVFKKASPNGKLTVYLGKRDFVDHIDLVDPVDGVVLVDPEYLKERRVYVTLTCAFRYGREDLDVLGLTFRKDLFVANVQSFPPAPE---DKKP------LTRLQERLIKKLGEHAYPFTFEIPPNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGPQPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAMEEADD---TVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLVVSRGGLLGDLASSDVAVELPFTLMHPKPKEEPP----------HREVPENETP--------------------------VDTNLIELDTN---------------DDDIVFEDFARQRLKG 398
BLAST of slc6a-8 vs. Ensembl Human
Match: ARRB2 (arrestin beta 2 [Source:HGNC Symbol;Acc:HGNC:712]) HSP 1 Score: 468.003 bits (1203), Expect = 1.489e-152 Identity = 250/458 (54.59%), Postives = 316/458 (69.00%), Query Frame = 3
Query: 144 EKETSKVFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFGTSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRLTGGDKND 1517
EK ++VFKKSSPN K+T YLGKRDF+D+LD VDPVDGVVL+DPDYLKDRKVFV + AFRYGREDLDVLGL+FRKDL++A+ Q + R TRLQ+RL++KLG +A+PF+F +P N P SVTLQPGP D GK CGVD+E++ + A + +EK+HKRNSV+L IRK+ +AP+KP PQPSAE + F+MS SL LEASLDKE YYHGE ++VNV V NNS KT+KKIK++VRQ+ADICL++ YKC V +LE +D S + +CKVY + PLLS+NR+KRGLALDGKLKHEDTNLASSTI+ E NKE LGI+V Y+VKV+LV+ G D+S+ELPF L HPKP D P + P+ E++VP +D +LI+ DT+ + DDD++FEDFARLRL G +D
Sbjct: 3 EKPGTRVFKKSSPNCKLTVYLGKRDFVDHLDKVDPVDGVVLVDPDYLKDRKVFVTLTCAFRYGREDLDVLGLSFRKDLFIATYQAF---------PPVPNPPRPPTRLQDRLLRKLGQHAHPFFFTIPQNLPCSVTLQPGPEDTGKACGVDFEIRAFCAKSLEEKSHKRNSVRLVIRKVQFAPEKPGPQPSAETTRHFLMSDRSLHLEASLDKELYYHGEPLNVNVHVTNNSTKTVKKIKVSVRQYADICLFSTAQYKCPVAQLEQDDQV---SPSSTFCKVYTITPLLSDNREKRGLALDGKLKHEDTNLASSTIVKEGANKEVLGILVSYRVKVKLVVSRG-GDVSVELPFVLMHPKPHDHIP----------------LPRPQ-----SAAPETDVP-----------VDTNLIEFDTN------------YATDDDIVFEDFARLRLKGMKDDD 403
BLAST of slc6a-8 vs. Ensembl Human
Match: ARRB2 (arrestin beta 2 [Source:HGNC Symbol;Acc:HGNC:712]) HSP 1 Score: 456.062 bits (1172), Expect = 8.452e-148 Identity = 250/479 (52.19%), Postives = 316/479 (65.97%), Query Frame = 3
Query: 144 EKETSKVFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFE---------------------LPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFGTSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRLTGGDKND 1517
EK ++VFKKSSPN K+T YLGKRDF+D+LD VDPVDGVVL+DPDYLKDRKVFV + AFRYGREDLDVLGL+FRKDL++A+ Q + R TRLQ+RL++KLG +A+PF+F +P N P SVTLQPGP D GK CGVD+E++ + A + +EK+HKRNSV+L IRK+ +AP+KP PQPSAE + F+MS SL LEASLDKE YYHGE ++VNV V NNS KT+KKIK++VRQ+ADICL++ YKC V +LE +D S + +CKVY + PLLS+NR+KRGLALDGKLKHEDTNLASSTI+ E NKE LGI+V Y+VKV+LV+ G D+S+ELPF L HPKP D P + P+ E++VP +D +LI+ DT+ + DDD++FEDFARLRL G +D
Sbjct: 3 EKPGTRVFKKSSPNCKLTVYLGKRDFVDHLDKVDPVDGVVLVDPDYLKDRKVFVTLTCAFRYGREDLDVLGLSFRKDLFIATYQAF---------PPVPNPPRPPTRLQDRLLRKLGQHAHPFFFTVRMPLPSEGQGAGAGTVSGVGIPQNLPCSVTLQPGPEDTGKACGVDFEIRAFCAKSLEEKSHKRNSVRLVIRKVQFAPEKPGPQPSAETTRHFLMSDRSLHLEASLDKELYYHGEPLNVNVHVTNNSTKTVKKIKVSVRQYADICLFSTAQYKCPVAQLEQDDQV---SPSSTFCKVYTITPLLSDNREKRGLALDGKLKHEDTNLASSTIVKEGANKEVLGILVSYRVKVKLVVSRG-GDVSVELPFVLMHPKPHDHIP----------------LPRPQ-----SAAPETDVP-----------VDTNLIEFDTN------------YATDDDIVFEDFARLRLKGMKDDD 424
BLAST of slc6a-8 vs. Ensembl Human
Match: ARRB2 (arrestin beta 2 [Source:HGNC Symbol;Acc:HGNC:712]) HSP 1 Score: 432.18 bits (1110), Expect = 4.566e-139 Identity = 237/458 (51.75%), Postives = 302/458 (65.94%), Query Frame = 3
Query: 144 EKETSKVFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFGTSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRLTGGDKND 1517
EK ++VFKKSSPN K+T YLGKRDF+D+LD VDPV VFV + AFRYGREDLDVLGL+FRKDL++A+ Q + R TRLQ+RL++KLG +A+PF+F +P N P SVTLQPGP D GK CGVD+E++ + A + +EK+HKRNSV+L IRK+ +AP+KP PQPSAE + F+MS SL LEASLDKE YYHGE ++VNV V NNS KT+KKIK++VRQ+ADICL++ YKC V +LE +D S + +CKVY + PLLS+NR+KRGLALDGKLKHEDTNLASSTI+ E NKE LGI+V Y+VKV+LV+ G D+S+ELPF L HPKP D P L +S + E++VP +D +LI+ DT+ + DDD++FEDFARLRL G +D
Sbjct: 3 EKPGTRVFKKSSPNCKLTVYLGKRDFVDHLDKVDPV---------------VFVTLTCAFRYGREDLDVLGLSFRKDLFIATYQAF---------PPVPNPPRPPTRLQDRLLRKLGQHAHPFFFTIPQNLPCSVTLQPGPEDTGKACGVDFEIRAFCAKSLEEKSHKRNSVRLVIRKVQFAPEKPGPQPSAETTRHFLMSDRSLHLEASLDKELYYHGEPLNVNVHVTNNSTKTVKKIKVSVRQYADICLFSTAQYKCPVAQLEQDDQV---SPSSTFCKVYTITPLLSDNREKRGLALDGKLKHEDTNLASSTIVKEGANKEVLGILVSYRVKVKLVVSRG-GDVSVELPFVLMHPKPHDHIP---------LPRPQSAPTPTPPLPVPPAAPETDVP-----------VDTNLIEFDTN------------YATDDDIVFEDFARLRLKGMKDDD 400
BLAST of slc6a-8 vs. Ensembl Celegans
Match: arr-1 (Beta-arrestin arr-1 [Source:UniProtKB/Swiss-Prot;Acc:P51485]) HSP 1 Score: 451.44 bits (1160), Expect = 2.918e-146 Identity = 264/483 (54.66%), Postives = 322/483 (66.67%), Query Frame = 3
Query: 111 LDDIKKQGTSKEKETSKVFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKD-RKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVA---DNPDEKAHKR---NSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFGTSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRLTGGDKNDP*PRPAP 1538
+D+ KK GT +VFKK+SPNGKIT YLGKRDFID DYVD +DG+VLID +Y+KD RKV H+LAAFRYGREDLDVLGLTFRKDL + QVYP +K IS R L+RLQERL +KLG NA+PF+FE+ + +SVTLQP P D GKPCGVDYELKT+VA + EK K N+V+LAIRKLTYAP + PQP ++ K F+MS G L +E SLDKE YYHGESISVNV + NNSNKT+KK+KI + Q ADICL+ SY C V +E +GFP+ T KV+ VCPLLSNN+DKRGLALDG+LKHEDTNLASSTI++ T+KE+LGI+VQY+VKVR VLG ++ ELPFTL+H KP +SPE T+ +P+ + + S +D DLIQL + R DDDLIFEDFAR+RL G D D +P+P
Sbjct: 2 VDEDKKSGT-------RVFKKTSPNGKITTYLGKRDFIDRGDYVDLIDGMVLIDEEYIKDNRKVTAHLLAAFRYGREDLDVLGLTFRKDLISETFQVYPQTDK-------SIS-RPLSRLQERLKRKLGANAFPFWFEVAPKSASSVTLQPAPGDTGKPCGVDYELKTFVAVTDGSSGEKPKKSALSNTVRLAIRKLTYAPFESRPQPMVDVSKYFMMSSGLLHMEVSLDKEMYYHGESISVNVHIQNNSNKTVKKLKIYIIQVADICLFTTASYSCEVARIESNEGFPVGPGGT-LSKVFAVCPLLSNNKDKRGLALDGQLKHEDTNLASSTILDSKTSKESLGIVVQYRVKVRAVLGPLNGELFAELPFTLTHSKPP---------------------ESPE-------RTDRGLPSIE-ATNGSEPVDIDLIQLHEELEPR----------YDDDLIFEDFARMRLHGNDSED---QPSP 426
BLAST of slc6a-8 vs. Ensembl Celegans
Match: dat-1 (Sodium-dependent dopamine transporter [Source:UniProtKB/Swiss-Prot;Acc:Q03614]) HSP 1 Score: 350.903 bits (899), Expect = 1.908e-106 Identity = 190/395 (48.10%), Postives = 262/395 (66.33%), Query Frame = 2
Query: 1982 DESKNLENHSDPQTRKHWASQLDFLFSIIGFAVDFSNVFRFPYICFQNGGGAFLIPYFVTLLLCALPMFYIELLFGQYMRCGGLTIW-KICPLFKGVGYASVLLNFYVALYYNVIIAWSLYYLFVSFSPTLPWTVCDKWWNSENCY--FISNYLSLLEKNNNTNMFTD---SATEYLENNVLMVNQSSG--------IGNLGPLKWNMAXXXXXXXXXXXXXXFKGVKFLGKAVWVTAILPYVVLAALLIRGVMLEGAVEGIKYFITPNFKMLLKPDVWIAAATQIFFSVGVGFSVHIAYASYNNFHTPVHNNCLIAAAVNSLTSLFSGFVIFAYLGYMSHQMRKPLEKVVNGNLTLIFIVYPLALSTLPGGNFWAVIFFLMLFNLGLDSSVRAS 3124
D N E DP R+ W+ +LDFL S++GFAVD N++RFPY+CF+NGGG FLIPY + +LL +P+FY+EL GQY R G +T W +ICPLFKG+GY +L FYV +YNVI+AW L+YL+ SFS LPW C+ +NS CY S + + ++ N ++ + +A EY L +++++ + +LG ++W++ALSL ++Y+I Y ++KG+ GK VW TA+ PYVVL L IRGV L G GI+Y++ PNF+ML +P VW AATQ+FFS+G GF V +AY+SYN+FH V+ + L + +N TS SGFVIF+ LGYMS + KP+E V L+F+VYP ALST+P FW+V+FFLML LGLDSS S
Sbjct: 28 DGPVNTE-PKDP-AREQWSGKLDFLLSVVGFAVDLGNIWRFPYLCFKNGGGVFLIPYSIMVLLTGVPLFYMELCLGQYYRKGAITTWGRICPLFKGIGYCVILTAFYVDFFYNVILAWGLHYLYTSFSFNLPWASCNNSYNSPACYEPHWSEDGTAMCRSANQSVSAEKISAAEEYFYKGFLGLHEANAPNSHVIRSVTDLGNVRWDIALSLFVVYLICYFSMWKGIHTSGKVVWFTALFPYVVLGILFIRGVTLPGWQNGIEYYLRPNFEMLKRPSVWQDAATQVFFSLGPGFGVLMAYSSYNDFHNNVYVDALFTSFINCATSFLSGFVIFSVLGYMSCKSGKPIEAVAQEGPGLVFVVYPEALSTMPYAPFWSVLFFLMLMTLGLDSSFGGS 420
BLAST of slc6a-8 vs. Ensembl Celegans
Match: mod-5 (Transporter [Source:UniProtKB/TrEMBL;Acc:Q9N3C7]) HSP 1 Score: 323.168 bits (827), Expect = 1.202e-102 Identity = 170/376 (45.21%), Postives = 253/376 (67.29%), Query Frame = 2
Query: 2003 NHSDPQTRKHWASQLDFLFSIIGFAVDFSNVFRFPYICFQNGGGAFLIPYFVTLLLCALPMFYIELLFGQYMRCGGLTIW-KICPLFKGVGYASVLLNFYVALYYNVIIAWSLYYLFVSFSP----TLPWTVCDKWWNSENCYFISNYLSLLEKNNNTNMFTDSATEYLENNVLMVNQSSGIGNLGPLKWNMAXXXXXXXXXXXXXXFKGVKFLGKAVWVTAILPYVVLAALLIRGVMLEGAVEGIKYFITPNFKMLLKPDVWIAAATQIFFSVGVGFSVHIAYASYNNFHTPVHNNCLIAAAVNSLTSLFSGFVIFAYLGYMSHQMRKPLEKVV-NGNLTLIFIVYPLALSTLPGGNFWAVIFFLMLFNLGLDSS 3112
R WA++++FL +++G+AVD N++RFP +C+++GGGAFLIPYF+ L++ LPMFY+EL+ GQ+ R G ++IW K+CPLF+G+GY + ++A++YN IIA ++Y+ VS S +PW C WN+ C S+ L++ N T + T S EY VL V +S+G +LG +K +MA+ LL ++I++Y L+KG + GK VWVTA PY++L+ LLIRG++L GA G+ Y++TP+F+ L P VW AAATQIFFS+G GF V +A +SYN+F+ + + + + +N TS FSG V+F+ LGYMS KP+ +VV + +LIFIVYP AL+T+ FW+ IFF+ML LG+DS+
Sbjct: 93 RRRSSMVRDKWATKMEFLLAVVGYAVDLGNIWRFPSVCYKHGGGAFLIPYFIMLMIGGLPMFYMELVLGQFHRSGCVSIWRKVCPLFRGIGYGICCICTFIAIFYNAIIAQAVYFAIVSLSKIWDSEVPWASCGNPWNTPRC---SDDLNVTISRNGTPLTTPSE-EYYLYKVLEVQKSTGFDDLGGVKTSMAVCLLAVFIMVYFALWKGPQSSGKIVWVTATAPYIILSILLIRGLLLPGAKNGLYYYVTPDFEKLKDPAVWSAAATQIFFSLGPGFGVLLALSSYNDFNNNCYRDAVTTSIINCATSFFSGCVVFSTLGYMSLLTNKPINEVVGEHDASLIFIVYPQALATMDYSCFWSFIFFVMLITLGIDST 464 HSP 2 Score: 71.633 bits (174), Expect = 1.202e-102 Identity = 46/141 (32.62%), Postives = 69/141 (48.94%), Query Frame = 1
Query: 3157 FGALEALLTGILDEFDFVFKKMKYKREITTAVMLTILYFLSLPNTTYGGFFLIQLYDKYSAGPSLLAVSLLECIGFIWIYGIDNTADIIKQMNGFDLHIIFRILFKYITPFAILAITIAQLFTDEIFTVNLGTRTYTYPQW 3579
F +EA +TG DE F+ K K+ V+ I YFLS P +YGG F+I D+Y S+L + E I W YG+D + I+ M GF I +R+ + +P I I I ++ + + +YT+P W
Sbjct: 465 FAGIEAFITGFCDESRFLSKNRKW----FVLVICIIYYFLSFPAISYGGQFVIPFLDEYGVSLSVLFIVTCEMIAVCWFYGVDQFSKDIRAMLGFYPGIYWRVCWT-CSPVFISVIFIMTVYNSSFKPIQMA--SYTFPWW 598
BLAST of slc6a-8 vs. Ensembl Celegans
Match: snf-11 (Transporter [Source:UniProtKB/TrEMBL;Acc:G5EF43]) HSP 1 Score: 295.049 bits (754), Expect = 2.981e-95 Identity = 165/399 (41.35%), Postives = 247/399 (61.90%), Query Frame = 2
Query: 2024 RKHWASQLDFLFSIIGFAVDFSNVFRFPYICFQNGGGAFLIPYFVTLLLCALPMFYIELLFGQYMRCGGLTIWKICPLFKGVGYASVLLNFYVALYYNVIIAWSLYYLFVSFSPT-LPWTVCDKWWNSENCYFISNYLSLLEKNNNT--------NMFTDSATEYLEN---------------------------NVLMVNQSSGIGNLGPLKWNMAXXXXXXXXXXXXXXFKGVKFLGKAVWVTAILPYVVLAALLIRGVMLEGAVEGIKYFITPNFKMLLKPDVWIAAATQIFFSVGVGFSVHIAYASYNNFHTPVHNNCLIAAAVNSLTSLFSGFVIFAYLGYMSHQMRKPLEKVVNGNLTLIFIVYPLALSTLPGGNFWAVIFFLMLFNLGLDSS 3112
R+ W+S DF+ S IG+A+ NV+RFPY+C+QNGGGAFLIPY ++L+ C P+F +E +GQ M GGL ++KICP+FKGVG A+ ++ F++ +YY V+++W+ YL+ SF+ + +PW CD WN+ NC S Y+ + +N T + D EY + N ++ SSG+ N G ++W++AL LLL++II YLC+FKGVK+ GK V++TA PY++L LLIRG+ LEGA G+++++ P+F LL+ VW+ A TQ+FFS G+G +A SYN F+ V+ L VNS TS+F+GFVIF+++G+M+ Q K + +V L+F+ YP + LP FW+ +FFLM+ LG+DS
Sbjct: 10 REQWSSWADFIMSCIGYAIGLGNVWRFPYLCYQNGGGAFLIPYCISLVFCGAPLFILETSWGQLMSVGGLGMFKICPIFKGVGIAAAVMAFWLNIYYIVVLSWAATYLYNSFTMSDVPWKNCDHAWNTPNCR--SEYVKIPCDSNRTIAEFFNVKVLTHDHIHEYKKQFFVGEKMNWTVCSAADLSVVSPVKEFWNHRVLGISSGLENPGGIRWDLALFLLLVWIICYLCIFKGVKWTGKVVYITASFPYMMLFCLLIRGLTLEGAGVGLEFYLKPDFSKLLESKVWVDAVTQVFFSYGLGLGALVALGSYNKFNNNVYKQALTVCFVNSGTSVFAGFVIFSFIGFMATQQEKSVAEVAQAGPGLLFLAYPSGILQLPYTQFWSCLFFLMVLFLGVDSQ 406 HSP 2 Score: 75.485 bits (184), Expect = 2.981e-95 Identity = 47/143 (32.87%), Postives = 71/143 (49.65%), Query Frame = 1
Query: 3154 QFGALEALLTGILDEFDFVFKKMKYKREITTAVMLTILYFLSLPNTTYGGFFLIQLYDKYSA-GPSLLAVSLLECIGFIWIYGIDNTADIIKQMNGFDLHIIFRILFKYITPFAILAITIAQLFTDEIFTVNLGTRTYTYPQW 3579
QF +E T I+DEF + +K KY REI V+ I Y + L T GGF++ QL+D Y+A G +LL + ECI W GID + +K M G+ ++ + + TP + + L + ++ Y YP W
Sbjct: 406 QFCTMEGFFTAIIDEFPQIRRK-KYGREIFVGVICVISYLIGLTTVTEGGFYVFQLFDFYAASGWALLWLLFFECIAISWSLGIDRWYEHMKSMIGYYPSAWWKFCWVFATPSVCFGVLLFGLIKYQPLRID--AYNYDYPVW 545
BLAST of slc6a-8 vs. Ensembl Celegans
Match: snf-3 (Sodium- and chloride-dependent betaine transporter [Source:UniProtKB/Swiss-Prot;Acc:G5EBN9]) HSP 1 Score: 271.552 bits (693), Expect = 2.294e-78 Identity = 143/390 (36.67%), Postives = 224/390 (57.44%), Query Frame = 2
Query: 1967 LAENSDESKNLEN--HSDPQTRKHWASQLDFLFSIIGFAVDFSNVFRFPYICFQNGGGAFLIPYFVTLLLCALPMFYIELLFGQYMRCGGLTIWKICPLFKGVGYASVLLNFYVALYYNVIIAWSLYYLFVSFSPTLPWTVCDKWWNSENCYFISNYLSLLEK-----NNNTNMFTDSATEYLENNVLMVNQSSGIGNLGPLKWNMAXXXXXXXXXXXXXXFKGVKFLGKAVWVTAILPYVVLAALLIRGVMLEGAVEGIKYFITPNFKMLLKPDVWIAAATQIFFSVGVGFSVHIAYASYNNFHTPVHNNCLIAAAVNSLTSLFSGFVIFAYLGYMSHQMRKPLEKVVNGNLTLIFIVYPLALSTLPGGNFWAVIFFLMLFNLGLDSSV 3115
L + ++K LE HS+ R W + DFL S++ +AV NV+RFPY+C++NGGG+FL+ Y + L A+P+F +E+ GQY++ G + +W +CPLF+GVG +V++ F Y+ VI+AW+++Y+ S + PW C+ +WN C + L + + S ++ E VL + + I G ++W + + ++I+Y L+KG+ K V+ A+ PYV++ LLIRG+ LEGA GI +++ PN LL VW A TQ+F+S GVGF IA S+N F+ + + +N TS+ +GF +F+ LGYMSH +K + ++V + L F+ YP S LP +AV+FFLM+ LGLDS V
Sbjct: 9 LPTDEAKAKELEQSQHSEEPDRGQWTGKFDFLMSMVAYAVGLGNVWRFPYLCYKNGGGSFLVVYMIFFCLAAVPIFLMEVTVGQYLQKGAMEMWLMCPLFRGVGIGNVVIAFMCIAYFCVIVAWAMFYMISSIAWVFPWETCNNYWNDATCVTGKENFTELARIKALVASAGGHTQTSVEQFWEKRVL--HDTGDISEFGGIQWELFFIMAAAWLIVYFALWKGITQARKFVYFCALFPYVLIFILLIRGLTLEGAGTGIYFYLKPNATRLLDTAVWKDAGTQVFYSYGVGFGALIALGSHNKFNHNCFKDAITMCFINGCTSITAGFAVFSILGYMSHVAQKDISEIVKPGVGLAFLAYPEVASNLPMKQVFAVLFFLMITILGLDSQV 396
BLAST of slc6a-8 vs. Ensembl Fly
Match: krz (gene:FBgn0040206 transcript:FBtr0305268) HSP 1 Score: 464.922 bits (1195), Expect = 9.536e-151 Identity = 254/463 (54.86%), Postives = 321/463 (69.33%), Query Frame = 3
Query: 135 TSKEKETSKVFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLG--FGTSDISLELPFTLSHPKPADEE-PNMSNFTFEDLHSNKSKIQSP--EIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRLTGGD 1508
S ++ ++VFKKSS NGKIT YLGKRDF+D++ +VDP+DGVV IDP+Y+KDRKVF VLAAFRYGREDLDVLGLTFRKDLYLA +Q+YPP+ +R +TRLQERLIKKLG NA+PFYFE+P PASV+LQP P D GK CGVDYELK +V +N ++K HKRNSV+L IRK+ YAP K QPS E+ K+F+M P + LEA+LDKE Y+HGE ISVNV V NNSN+T+KKIK+ VRQ ADICL++ YK +V E+E EDG + T KV+++CPLL+NN+DK GLALDG+LKHEDTNLASST+I +E+LGI+V YKVKV+L++ D+ ELPFTL HPKP +EE P + S ++ + ++S +D TES + + +LIQLD + DDD+IFEDFARLRL G +
Sbjct: 40 ASSRRQATRVFKKSSSNGKITVYLGKRDFVDHVTHVDPIDGVVFIDPEYVKDRKVFGQVLAAFRYGREDLDVLGLTFRKDLYLAHEQIYPPMQ----------LDRPMTRLQERLIKKLGPNAHPFYFEVPPYCPASVSLQPAPGDVGKSCGVDYELKAFVGENVEDKPHKRNSVRLTIRKVMYAPSKVGEQPSIEVSKEFMMKPNKIHLEATLDKELYHHGEKISVNVHVANNSNRTVKKIKVCVRQFADICLFSTAQYKSVVAEIESEDGCQVAPGFT-LSKVFELCPLLANNKDKWGLALDGQLKHEDTNLASSTLITNPAQRESLGIMVHYKVKVKLLISSPLLNGDLVAELPFTLMHPKPEEEEHPLLGE------RSPRASLAGGGLPLVSMSDGETESATGGQDVPTTT------NLIQLDDD------------EAQDDDIIFEDFARLRLKGAE 467
BLAST of slc6a-8 vs. Ensembl Fly
Match: krz (gene:FBgn0040206 transcript:FBtr0085877) HSP 1 Score: 464.922 bits (1195), Expect = 9.536e-151 Identity = 254/463 (54.86%), Postives = 321/463 (69.33%), Query Frame = 3
Query: 135 TSKEKETSKVFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLG--FGTSDISLELPFTLSHPKPADEE-PNMSNFTFEDLHSNKSKIQSP--EIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRLTGGD 1508
S ++ ++VFKKSS NGKIT YLGKRDF+D++ +VDP+DGVV IDP+Y+KDRKVF VLAAFRYGREDLDVLGLTFRKDLYLA +Q+YPP+ +R +TRLQERLIKKLG NA+PFYFE+P PASV+LQP P D GK CGVDYELK +V +N ++K HKRNSV+L IRK+ YAP K QPS E+ K+F+M P + LEA+LDKE Y+HGE ISVNV V NNSN+T+KKIK+ VRQ ADICL++ YK +V E+E EDG + T KV+++CPLL+NN+DK GLALDG+LKHEDTNLASST+I +E+LGI+V YKVKV+L++ D+ ELPFTL HPKP +EE P + S ++ + ++S +D TES + + +LIQLD + DDD+IFEDFARLRL G +
Sbjct: 40 ASSRRQATRVFKKSSSNGKITVYLGKRDFVDHVTHVDPIDGVVFIDPEYVKDRKVFGQVLAAFRYGREDLDVLGLTFRKDLYLAHEQIYPPMQ----------LDRPMTRLQERLIKKLGPNAHPFYFEVPPYCPASVSLQPAPGDVGKSCGVDYELKAFVGENVEDKPHKRNSVRLTIRKVMYAPSKVGEQPSIEVSKEFMMKPNKIHLEATLDKELYHHGEKISVNVHVANNSNRTVKKIKVCVRQFADICLFSTAQYKSVVAEIESEDGCQVAPGFT-LSKVFELCPLLANNKDKWGLALDGQLKHEDTNLASSTLITNPAQRESLGIMVHYKVKVKLLISSPLLNGDLVAELPFTLMHPKPEEEEHPLLGE------RSPRASLAGGGLPLVSMSDGETESATGGQDVPTTT------NLIQLDDD------------EAQDDDIIFEDFARLRLKGAE 467
BLAST of slc6a-8 vs. Ensembl Fly
Match: DAT (gene:FBgn0034136 transcript:FBtr0087125) HSP 1 Score: 367.851 bits (943), Expect = 6.646e-119 Identity = 192/408 (47.06%), Postives = 267/408 (65.44%), Query Frame = 2
Query: 2000 ENHSDPQTRKHWASQLDFLFSIIGFAVDFSNVFRFPYICFQNGGGAFLIPYFVTLLLCALPMFYIELLFGQYMRCGGLTIW-KICPLFKGVGYASVLLNFYVALYYNVIIAWSLYYLFVSFSPTLPWTVCDKWWNSENCY-----------FISNYLSLLEKNNNTNM---------------------FTDSATEYLENNVLMVNQSSGIGNLGPLKWNMAXXXXXXXXXXXXXXFKGVKFLGKAVWVTAILPYVVLAALLIRGVMLEGAVEGIKYFITPNFKMLLKPDVWIAAATQIFFSVGVGFSVHIAYASYNNFHTPVHNNCLIAAAVNSLTSLFSGFVIFAYLGYMSHQMRKPLEKVVNGNLTLIFIVYPLALSTLPGGNFWAVIFFLMLFNLGLDSSVRAS 3124
+N+S R+ W+ ++DFL S+IGFAVD +NV+RFPY+C++NGGGAFL+PY + L++ +P+FY+EL GQ+ R G +T W ++ PLFKG+GYA VL+ FYV YYNVIIAWSL + F SF+ +LPWT C+ WN+ NC I NY L N + + F +A+EY +L +N+S GI +LG +KW+MAL LL++Y+I Y L+KG+ GK VW TA+ PY VL LLIRG+ L G+ GI+Y++TPNF + K +VW+ AATQ+FFS+G GF V +AYASYN +H V+ + L+ + +NS TS +GFVIF+ LGYM+H + +E V L+F+VYP A++T+P FWA+IFF+ML LGLDSS S
Sbjct: 19 DNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFWALIFFMMLLTLGLDSSFGGS 426 HSP 2 Score: 81.6481 bits (200), Expect = 6.646e-119 Identity = 46/142 (32.39%), Postives = 74/142 (52.11%), Query Frame = 1
Query: 3154 QFGALEALLTGILDEFDFVFKKMKYKREITTAVMLTILYFLSLPNTTYGGFFLIQLYDKYSAGPSLLAVSLLECIGFIWIYGIDNTADIIKQMNGFDLHIIFRILFKYITPFAILAITIAQLFTDEIFTVNLGTRTYTYPQW 3579
FG EA++T + DEF K+K RE+ A + ++ + + L + T GGF+ L D+Y+AG S+L E I WIYG + ++ I+ M GF +++ ++++ P +L IT+ L E T Y YP W
Sbjct: 422 SFGGSEAIITALSDEF----PKIKRNRELFVAGLFSLYFVVGLASCTQGGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYGLIGYEPLTY----ADYVYPSW 555
BLAST of slc6a-8 vs. Ensembl Fly
Match: DAT (gene:FBgn0034136 transcript:FBtr0330002) HSP 1 Score: 367.466 bits (942), Expect = 9.988e-119 Identity = 192/408 (47.06%), Postives = 267/408 (65.44%), Query Frame = 2
Query: 2000 ENHSDPQTRKHWASQLDFLFSIIGFAVDFSNVFRFPYICFQNGGGAFLIPYFVTLLLCALPMFYIELLFGQYMRCGGLTIW-KICPLFKGVGYASVLLNFYVALYYNVIIAWSLYYLFVSFSPTLPWTVCDKWWNSENCY-----------FISNYLSLLEKNNNTNM---------------------FTDSATEYLENNVLMVNQSSGIGNLGPLKWNMAXXXXXXXXXXXXXXFKGVKFLGKAVWVTAILPYVVLAALLIRGVMLEGAVEGIKYFITPNFKMLLKPDVWIAAATQIFFSVGVGFSVHIAYASYNNFHTPVHNNCLIAAAVNSLTSLFSGFVIFAYLGYMSHQMRKPLEKVVNGNLTLIFIVYPLALSTLPGGNFWAVIFFLMLFNLGLDSSVRAS 3124
+N+S R+ W+ ++DFL S+IGFAVD +NV+RFPY+C++NGGGAFL+PY + L++ +P+FY+EL GQ+ R G +T W ++ PLFKG+GYA VL+ FYV YYNVIIAWSL + F SF+ +LPWT C+ WN+ NC I NY L N + + F +A+EY +L +N+S GI +LG +KW+MAL LL++Y+I Y L+KG+ GK VW TA+ PY VL LLIRG+ L G+ GI+Y++TPNF + K +VW+ AATQ+FFS+G GF V +AYASYN +H V+ + L+ + +NS TS +GFVIF+ LGYM+H + +E V L+F+VYP A++T+P FWA+IFF+ML LGLDSS S
Sbjct: 19 DNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFWALIFFMMLLTLGLDSSFGGS 426 HSP 2 Score: 81.6481 bits (200), Expect = 9.988e-119 Identity = 46/142 (32.39%), Postives = 74/142 (52.11%), Query Frame = 1
Query: 3154 QFGALEALLTGILDEFDFVFKKMKYKREITTAVMLTILYFLSLPNTTYGGFFLIQLYDKYSAGPSLLAVSLLECIGFIWIYGIDNTADIIKQMNGFDLHIIFRILFKYITPFAILAITIAQLFTDEIFTVNLGTRTYTYPQW 3579
FG EA++T + DEF K+K RE+ A + ++ + + L + T GGF+ L D+Y+AG S+L E I WIYG + ++ I+ M GF +++ ++++ P +L IT+ L E T Y YP W
Sbjct: 422 SFGGSEAIITALSDEF----PKIKRNRELFVAGLFSLYFVVGLASCTQGGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYGLIGYEPLTY----ADYVYPSW 555
BLAST of slc6a-8 vs. Ensembl Fly
Match: SerT (gene:FBgn0010414 transcript:FBtr0072362) HSP 1 Score: 363.614 bits (932), Expect = 5.016e-117 Identity = 183/366 (50.00%), Postives = 254/366 (69.40%), Query Frame = 2
Query: 2018 QTRKHWASQLDFLFSIIGFAVDFSNVFRFPYICFQNGGGAFLIPYFVTLLLCALPMFYIELLFGQYMRCGGLTIWK-ICPLFKGVGYASVLLNFYVALYYNVIIAWSLYYLFVSFSPTLPWTVCDKWWNSENCYFISNYLSLLEKNNNTNMFTDSATEYLENNVLMVNQSSGIGNLGPLKWNMAXXXXXXXXXXXXXXFKGVKFLGKAVWVTAILPYVVLAALLIRGVMLEGAVEGIKYFITPNFKMLLKPDVWIAAATQIFFSVGVGFSVHIAYASYNNFHTPVHNNCLIAAAVNSLTSLFSGFVIFAYLGYMSHQMRKPLEKVVNGNLTLIFIVYPLALSTLPGGNFWAVIFFLMLFNLGLDSS 3112
+TR+ W + +FL ++IGFAVD NV+RFPYIC+QNGGGAFL+PY + L+ LP+FY+EL GQ+ RCG L+IWK ICP KGVGYA L++ Y+ +YYN II W++YYLF SF+ LPWT CD WN+ENC +++ N T + T A E+ E VL + +G+ +GP+K +AL + +++++Y L+KGV+ GK VWVTA+ PYVVL LL+RGV L GA EGIKY++TP + L VWI AA+QIFFS+G GF +A +SYN F+ + + LI +++N LTS +GFVIF+ LGYM++ + ++KV L+FIVYP A++T+ G FW++IFFLML LGLDS+
Sbjct: 72 RTRETWGQKAEFLLAVIGFAVDLGNVWRFPYICYQNGGGAFLVPYCLFLIFGGLPLFYMELALGQFHRCGCLSIWKRICPALKGVGYAICLIDIYMGMYYNTIIGWAVYYLFASFTSKLPWTSCDNPWNTENCMQVTS-------ENFTELATSPAKEFFERKVLESYKGNGLDFMGPVKPTLALCVFGVFVLVYFSLWKGVRSAGKVVWVTALAPYVVLIILLVRGVSLPGADEGIKYYLTPEWHKLKNSKVWIDAASQIFFSLGPGFGTLLALSSYNKFNNNCYRDALITSSINCLTSFLAGFVIFSVLGYMAYVQKTSIDKVGLEGPGLVFIVYPEAIATMSGSVFWSIIFFLMLITLGLDST 430 HSP 2 Score: 80.1073 bits (196), Expect = 5.016e-117 Identity = 47/141 (33.33%), Postives = 75/141 (53.19%), Query Frame = 1
Query: 3157 FGALEALLTGILDEFDFVFKKMKYKREITTAVMLTILYFLSLPNTTYGGFFLIQLYDKYSAGPSLLAVSLLECIGFIWIYGIDNTADIIKQMNGFDLHIIFRILFKYITPFAILAITIAQLFTDEIFTVNLGTRTYTYPQW 3579
FG LEA++T + DE+ V + +RE+ ++L ++ +LP TYGG L+ + Y G ++L V +E G W YG+D + ++QM G + +RI + YI+P +L I I F+ + LG Y YP W
Sbjct: 431 FGGLEAMITALCDEYPRVIGR---RRELFVLLLLAFIFLCALPTMTYGGVVLVNFLNVYGPGLAILFVVFVEAAGVFWFYGVDRFSSDVEQMLGSKPGLFWRICWTYISPVFLLTIFI---FSIMGYKEMLG-EEYYYPDW 564
BLAST of slc6a-8 vs. Ensembl Zebrafish
Match: arrb2b (arrestin, beta 2b [Source:ZFIN;Acc:ZDB-GENE-040426-1332]) HSP 1 Score: 483.411 bits (1243), Expect = 1.248e-158 Identity = 259/453 (57.17%), Postives = 320/453 (70.64%), Query Frame = 3
Query: 144 EKETSKVFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFGTSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRLTG 1502
+K ++VFKKSSPN K+T YLGKRDF+D+LD+VDPVDGV+LIDP+YLKDRKVFV + AFRYGREDLDVLGL+FRKDL+++S Q YPPL PD + L+RLQERL+KKLG NAYPF F +P N P SVTLQPGP D GK CGVD+E++ + A DEK HKRNSV+L IRK+ YAP+KP PQP E + F+MS SL LEASLDKE YYHGE ISVNV V NNS KT+K++KI+VRQ+ADICL++ YKC V ++E +D SS + +CKVY + P LSNNR+KRGLALDG+LKHEDTNLASSTI+ + +NKE LGI+V Y+VKV+LV+ G D+S+ELPF L HPKP+ E+PN S+ QS E++VP +D +LI+ +T N S DDD +FEDFARLRL G
Sbjct: 3 DKAGTRVFKKSSPNCKLTVYLGKRDFVDHLDHVDPVDGVLLIDPEYLKDRKVFVTLTCAFRYGREDLDVLGLSFRKDLFISSFQAYPPL--------PD-ERKPLSRLQERLLKKLGQNAYPFNFTIPQNLPCSVTLQPGPEDTGKACGVDFEVRAFCAKTVDEKTHKRNSVRLVIRKVQYAPEKPGPQPMVETTRSFLMSDRSLHLEASLDKELYYHGEPISVNVHVTNNSTKTVKRVKISVRQYADICLFSTAQYKCPVAQVEADDQV---SSSSTFCKVYTLTPTLSNNREKRGLALDGQLKHEDTNLASSTIVKDVSNKEVLGILVSYRVKVKLVVSRG-GDVSVELPFVLMHPKPS-EQPN-------------SRPQS--------AVPETDVP-----------VDANLIEFET-----------NNFSQDDDFVFEDFARLRLKG 398
BLAST of slc6a-8 vs. Ensembl Zebrafish
Match: arrb1 (arrestin, beta 1 [Source:ZFIN;Acc:ZDB-GENE-060824-1]) HSP 1 Score: 474.552 bits (1220), Expect = 3.631e-155 Identity = 255/457 (55.80%), Postives = 311/457 (68.05%), Query Frame = 3
Query: 156 SKVFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFG-------TSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRLTGG 1505
++VFKK+SPNGK+T YLGKRDF+D++D V+PVDGVVLIDP+YLK+RKVFV + AFRYGREDLDVLGLTFRKDL++A+ Q +PP+ + + LTRLQERLIKKLG +AYPF FE+P N P SVTLQPGP D GK CGVD+E+K + A+N +EK HKRNSV+L IRK+ YAP+KP PQP AE + F+MS L LEASLDKE YYHGE ISVNV V NN+NKT+KKIKI+VRQ+ADICL+N YKC V E +D I + +CKVY + P L+NNR+KRGLALDGKLKHEDTNLASST++ E NKE LGIIV YKVKV+LV+ G +SD+++ELPFTL HPKP +E + D N + ID +LI+ DT+ DDD+IFEDFAR RL G
Sbjct: 6 TRVFKKASPNGKLTVYLGKRDFVDHVDLVEPVDGVVLIDPEYLKERKVFVTLTCAFRYGREDLDVLGLTFRKDLFVANIQAFPPVPE---------EKKSLTRLQERLIKKLGEHAYPFTFEIPPNLPCSVTLQPGPEDTGKACGVDFEVKAFCAENVEEKIHKRNSVRLVIRKVQYAPEKPGPQPMAETTRQFLMSDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAIEESDD---IVAPSATFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLREGANKEILGIIVSYKVKVKLVVSRGGLLGDLASSDVAVELPFTLMHPKPLEES------IYRDAPENDAP------------------------------IDTNLIEFDTN---------------DDDIIFEDFARQRLIGA 399
BLAST of slc6a-8 vs. Ensembl Zebrafish
Match: arrb2a (arrestin, beta 2a [Source:ZFIN;Acc:ZDB-GENE-030131-29]) HSP 1 Score: 466.848 bits (1200), Expect = 2.201e-152 Identity = 248/453 (54.75%), Postives = 317/453 (69.98%), Query Frame = 3
Query: 144 EKETSKVFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFGTSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRLTG 1502
+K ++VFKKSSPN K+T YLGKRDF+D+LD+VDPVDGV+L+DP+YLKDRKVFV + AFRYGREDLDVLGL+FRKDLY+ + Q YPP+ + ++ +RLQERL+KKLG NAYPF+F +P N P SVTLQPGP D GK CGVD+E++ + A + +EK HKRNSV+L IRK+ YAP+KP PQP E + F+MS SL LEASLDKE YYHGE ISVNV V NNS KT+K++KI+VRQ+ADICL++ YKC V ++E +D +S + +CKVY + P L+NNR+KRGLALDGKLKHEDTNLASSTI+ + +NKE LG++V Y+VKV+LV+ G D+S+ELPF L HPKP+ + ++ S VP +L+ ID +LI+ DT N L DDD++FEDFARLRL G
Sbjct: 3 DKAGTRVFKKSSPNCKVTVYLGKRDFVDHLDHVDPVDGVILVDPEYLKDRKVFVTLTCAFRYGREDLDVLGLSFRKDLYIFTFQAYPPIPE---------ESKPHSRLQERLLKKLGQNAYPFHFSIPQNLPCSVTLQPGPEDTGKACGVDFEIRAFCAKSMEEKNHKRNSVRLVIRKVQYAPEKPGPQPMVETTRSFLMSDRSLHLEASLDKELYYHGEPISVNVHVTNNSTKTVKRVKISVRQYADICLFSTAQYKCPVAQIEADDQV---ASSSTFCKVYTLTPTLNNNREKRGLALDGKLKHEDTNLASSTIVKDVSNKEVLGVLVSYRVKVKLVVSRG-GDVSVELPFVLMHPKPS---------------------------ESSLSHSTSAVP---MLDPP---IDTNLIEFDT-----------NSLIPDDDIVFEDFARLRLKG 398
BLAST of slc6a-8 vs. Ensembl Zebrafish
Match: arrb2a (arrestin, beta 2a [Source:ZFIN;Acc:ZDB-GENE-030131-29]) HSP 1 Score: 464.151 bits (1193), Expect = 3.169e-151 Identity = 248/460 (53.91%), Postives = 317/460 (68.91%), Query Frame = 3
Query: 144 EKETSKVFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFG-------TSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRLTG 1502
+K ++VFKKSSPN K+T YLGKRDF+D+LD+VDPVDGV+L+DP+YLKDRKVFV + AFRYGREDLDVLGL+FRKDLY+ + Q YPP+ + ++ +RLQERL+KKLG NAYPF+F +P N P SVTLQPGP D GK CGVD+E++ + A + +EK HKRNSV+L IRK+ YAP+KP PQP E + F+MS SL LEASLDKE YYHGE ISVNV V NNS KT+K++KI+VRQ+ADICL++ YKC V ++E +D +S + +CKVY + P L+NNR+KRGLALDGKLKHEDTNLASSTI+ + +NKE LG++V Y+VKV+LV+ G D+S+ELPF L HPKP+ + ++ S VP +L+ ID +LI+ DT N L DDD++FEDFARLRL G
Sbjct: 3 DKAGTRVFKKSSPNCKVTVYLGKRDFVDHLDHVDPVDGVILVDPEYLKDRKVFVTLTCAFRYGREDLDVLGLSFRKDLYIFTFQAYPPIPE---------ESKPHSRLQERLLKKLGQNAYPFHFSIPQNLPCSVTLQPGPEDTGKACGVDFEIRAFCAKSMEEKNHKRNSVRLVIRKVQYAPEKPGPQPMVETTRSFLMSDRSLHLEASLDKELYYHGEPISVNVHVTNNSTKTVKRVKISVRQYADICLFSTAQYKCPVAQIEADDQV---ASSSTFCKVYTLTPTLNNNREKRGLALDGKLKHEDTNLASSTIVKDVSNKEVLGVLVSYRVKVKLVVSRGGLLSSLLERDVSVELPFVLMHPKPS---------------------------ESSLSHSTSAVP---MLDPP---IDTNLIEFDT-----------NSLIPDDDIVFEDFARLRLKG 406
BLAST of slc6a-8 vs. Ensembl Zebrafish
Match: slc6a2 (solute carrier family 6 member 2 [Source:ZFIN;Acc:ZDB-GENE-110408-4]) HSP 1 Score: 360.147 bits (923), Expect = 1.007e-121 Identity = 190/419 (45.35%), Postives = 270/419 (64.44%), Query Frame = 2
Query: 1871 KMQNIELNESKLI--KSHXXXXXXXXXXCRTIALLAENSDESKNLENHSDPQTRKHWASQLDFLFSIIGFAVDFSNVFRFPYICFQNGGGAFLIPYFVTLLLCALPMFYIELLFGQYMRCGGLTIWKICPLFKGVGYASVLLNFYVALYYNVIIAWSLYYLFVSFSPTLPWTVCDKWWNSENCYFISNYLSLLEKNNNT--NMFTDSATEYLENNVLMVNQSSGIGNLGPLKWNMAXXXXXXXXXXXXXXFKGVKFLGKAVWVTAILPYVVLAALLIRGVMLEGAVEGIKYFITPNFKMLLKPDVWIAAATQIFFSVGVGFSVHIAYASYNNFHTPVHNNCLIAAAVNSLTSLFSGFVIFAYLGYMSHQMRKPLEKVVNGNLTLIFIVYPLALSTLPGGNFWAVIFFLMLFNLGLDSSV 3115
K N+E E +LI K N + N S + + A S + +E R+ W ++DFL S+IGFAVD +NV+RFPY+C++NGGGAFLIPY + L + +P+FY+EL GQY R G T+WKICP+FKGVGY +++ YV YYNVIIAWSLYYL+ S + LPW C+ WNS NC + + N + A E+ E VL ++S GIG+LG +W + + L+++ I+Y L+KGVK GK V++TA +PY+VL LLIRG+ L GA+ GI+ ++ + K L P VWI AATQIFFS+G GF V IA++SYN F+ + + ++ + +N +TS FSGF IF+ LGYM+ Q + ++ V L+F++YP A+STLPG F+A++FF+ML LG+DSS+
Sbjct: 18 KQFNVEKKEVELILVKEQNGVQYTNSSVVASPSSRACTSASGEEIE-------RETWGKKMDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLIPYVLFLFIAGMPLFYMELALGQYNREGAATLWKICPVFKGVGYTVIVIALYVGFYYNVIIAWSLYYLYASLTSELPWLHCNNPWNSPNCTEPKDINGTVLGNGTSYAKYKNTPAAEFYERGVLHSHESKGIGDLGLPRWELTICLVVVAFILYFSLWKGVKSSGKVVYITATMPYIVLLVLLIRGITLPGAMNGIRAYLHIDLKKLNNPQVWIDAATQIFFSLGAGFGVLIAFSSYNKFNNNCYRDAILTSTINCVTSFFSGFAIFSVLGYMAEQHKVNIKDVATEGAGLVFVIYPEAISTLPGATFFAIVFFIMLLTLGIDSSM 429 HSP 2 Score: 99.3673 bits (246), Expect = 1.007e-121 Identity = 65/208 (31.25%), Postives = 119/208 (57.21%), Query Frame = 1
Query: 3154 QFGALEALLTGILDEFDFVFKKMKYKREITTAVMLTILYFLSLPNTTYGGFFLIQLYDKYSAGPSLLAVSLLECIGFIWIYGIDNTADIIKQMNGFDLHIIFRILFKYITPFAILAITIAQLFTDEIFTVNLGTRTYTYPQWXXXXXXXXXXXXXXXXXXFGGVVLYRIKATSWKERICLSISPNWEHRDIRSKTQFNRLKINHWITV 3777
G +EA+LTG+ D+F K +K R++ T + + ++L T GG +++ L DKY+AG S+L L E IG W YG+D ++ I++M GF I +R+ +K+++P +L + IA + T T + Y +P W+ ++G I+LSS++ +P + + + +S+KER+ ++P EH + ++ + K+ HW+T+
Sbjct: 428 SMGGMEAVLTGLSDDF----KILKRNRKLFTFATVVGTFLMALLCVTNGGIYVLTLLDKYAAGTSILFGVLFEAIGVSWFYGVDRFSEDIERMMGFKPGIYWRLCWKFVSPAFLLLVVIASIVTSGRLTYD----EYVFPYWADMLGWSIALSSMLFVPFYAIYKFFSVP-SSFKERLAYCVTPEHEHH-LVAEGNVRQFKLKHWLTI 625
BLAST of slc6a-8 vs. Ensembl Xenopus
Match: ARRB1 (arrestin beta 1 [Source:NCBI gene;Acc:100486349]) HSP 1 Score: 427.172 bits (1097), Expect = 3.468e-137 Identity = 248/447 (55.48%), Postives = 307/447 (68.68%), Query Frame = 3
Query: 162 VFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFGTSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRLTG 1502
V +S P +T YLGKRDF+D++D VDPVDGVVL+DP+YLK+RKVFV + AFRYGREDLDVLGLTFRKDL++A+ Q +PP+ + +K P LTRLQERLIKKLG +AYPF FE+P N P SVTLQPGP D GK CGVDYE+K + A+N +EK HKRNSV+L IRK+ YAP++P PQP AE + F+MS L LEASLDKE YYHGE I+VNV V NN+NKT+KKIKI+VRQ+ADICL+N YKC V E ++ + + + +CKVY + P L+NNR+KRGLALDGKLKHEDTNLASST++ + NKE LGIIV YKVKV+LV+ G D+++ELPFTL HPKP EEP LH + ++P ID +LI+ DT+ DDD++FEDFAR RL G
Sbjct: 3 VSGRSCPPVALTVYLGKRDFVDHIDVVDPVDGVVLVDPEYLKERKVFVTLTCAFRYGREDLDVLGLTFRKDLFVANIQAFPPVPE---EKKP------LTRLQERLIKKLGEHAYPFTFEIPPNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGPQPMAETTRQFLMSDKPLHLEASLDKEIYYHGEPINVNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAVEEADND--VVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLRDGANKEILGIIVSYKVKVKLVVSRG-GDVAVELPFTLMHPKPT-EEP---------LHREVPENEAP--------------------------IDTNLIEFDTN---------------DDDIVFEDFARQRLKG 386
BLAST of slc6a-8 vs. Ensembl Xenopus
Match: ARRB1 (arrestin beta 1 [Source:NCBI gene;Acc:100486349]) HSP 1 Score: 424.476 bits (1090), Expect = 3.373e-136 Identity = 245/437 (56.06%), Postives = 303/437 (69.34%), Query Frame = 3
Query: 192 ITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFGTSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRLTG 1502
+T YLGKRDF+D++D VDPVDGVVL+DP+YLK+RKVFV + AFRYGREDLDVLGLTFRKDL++A+ Q +PP+ + +K P LTRLQERLIKKLG +AYPF FE+P N P SVTLQPGP D GK CGVDYE+K + A+N +EK HKRNSV+L IRK+ YAP++P PQP AE + F+MS L LEASLDKE YYHGE I+VNV V NN+NKT+KKIKI+VRQ+ADICL+N YKC V E ++ + + + +CKVY + P L+NNR+KRGLALDGKLKHEDTNLASST++ + NKE LGIIV YKVKV+LV+ G D+++ELPFTL HPKP EEP LH + ++P ID +LI+ DT+ DDD++FEDFAR RL G
Sbjct: 13 LTVYLGKRDFVDHIDVVDPVDGVVLVDPEYLKERKVFVTLTCAFRYGREDLDVLGLTFRKDLFVANIQAFPPVPE---EKKP------LTRLQERLIKKLGEHAYPFTFEIPPNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGPQPMAETTRQFLMSDKPLHLEASLDKEIYYHGEPINVNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAVEEADND--VVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLRDGANKEILGIIVSYKVKVKLVVSRG-GDVAVELPFTLMHPKPT-EEP---------LHREVPENEAP--------------------------IDTNLIEFDTN---------------DDDIVFEDFARQRLKG 386
BLAST of slc6a-8 vs. Ensembl Xenopus
Match: ARRB1 (arrestin beta 1 [Source:NCBI gene;Acc:100486349]) HSP 1 Score: 424.861 bits (1091), Expect = 5.127e-136 Identity = 245/438 (55.94%), Postives = 304/438 (69.41%), Query Frame = 3
Query: 189 KITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFGTSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRLTG 1502
++T YLGKRDF+D++D VDPVDGVVL+DP+YLK+RKVFV + AFRYGREDLDVLGLTFRKDL++A+ Q +PP+ + +K P LTRLQERLIKKLG +AYPF FE+P N P SVTLQPGP D GK CGVDYE+K + A+N +EK HKRNSV+L IRK+ YAP++P PQP AE + F+MS L LEASLDKE YYHGE I+VNV V NN+NKT+KKIKI+VRQ+ADICL+N YKC V E ++ + + + +CKVY + P L+NNR+KRGLALDGKLKHEDTNLASST++ + NKE LGIIV YKVKV+LV+ G D+++ELPFTL HPKP EEP LH + ++P ID +LI+ DT+ DDD++FEDFAR RL G
Sbjct: 32 QLTVYLGKRDFVDHIDVVDPVDGVVLVDPEYLKERKVFVTLTCAFRYGREDLDVLGLTFRKDLFVANIQAFPPVPE---EKKP------LTRLQERLIKKLGEHAYPFTFEIPPNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGPQPMAETTRQFLMSDKPLHLEASLDKEIYYHGEPINVNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAVEEADND--VVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLRDGANKEILGIIVSYKVKVKLVVSRG-GDVAVELPFTLMHPKPT-EEP---------LHREVPENEAP--------------------------IDTNLIEFDTN---------------DDDIVFEDFARQRLKG 406
BLAST of slc6a-8 vs. Ensembl Xenopus
Match: ARRB1 (arrestin beta 1 [Source:NCBI gene;Acc:100486349]) HSP 1 Score: 424.476 bits (1090), Expect = 6.137e-136 Identity = 247/445 (55.51%), Postives = 306/445 (68.76%), Query Frame = 3
Query: 189 KITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFG-------TSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRLTG 1502
K+T YLGKRDF+D++D VDPVDGVVL+DP+YLK+RKVFV + AFRYGREDLDVLGLTFRKDL++A+ Q +PP+ + +K P LTRLQERLIKKLG +AYPF FE+P N P SVTLQPGP D GK CGVDYE+K + A+N +EK HKRNSV+L IRK+ YAP++P PQP AE + F+MS L LEASLDKE YYHGE I+VNV V NN+NKT+KKIKI+VRQ+ADICL+N YKC V E ++ + + + +CKVY + P L+NNR+KRGLALDGKLKHEDTNLASST++ + NKE LGIIV YKVKV+LV+ G +SD+++ELPFTL HPKP EEP LH + ++P ID +LI+ DT+ DDD++FEDFAR RL G
Sbjct: 25 KLTVYLGKRDFVDHIDVVDPVDGVVLVDPEYLKERKVFVTLTCAFRYGREDLDVLGLTFRKDLFVANIQAFPPVPE---EKKP------LTRLQERLIKKLGEHAYPFTFEIPPNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGPQPMAETTRQFLMSDKPLHLEASLDKEIYYHGEPINVNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAVEEADND--VVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLRDGANKEILGIIVSYKVKVKLVVSRGGLLGDLASSDVAVELPFTLMHPKPT-EEP---------LHREVPENEAP--------------------------IDTNLIEFDTN---------------DDDIVFEDFARQRLKG 407
BLAST of slc6a-8 vs. Ensembl Xenopus
Match: ARRB1 (arrestin beta 1 [Source:NCBI gene;Acc:100486349]) HSP 1 Score: 424.476 bits (1090), Expect = 9.674e-136 Identity = 246/445 (55.28%), Postives = 306/445 (68.76%), Query Frame = 3
Query: 189 KITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFG-------TSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRLTG 1502
++T YLGKRDF+D++D VDPVDGVVL+DP+YLK+RKVFV + AFRYGREDLDVLGLTFRKDL++A+ Q +PP+ + +K P LTRLQERLIKKLG +AYPF FE+P N P SVTLQPGP D GK CGVDYE+K + A+N +EK HKRNSV+L IRK+ YAP++P PQP AE + F+MS L LEASLDKE YYHGE I+VNV V NN+NKT+KKIKI+VRQ+ADICL+N YKC V E ++ + + + +CKVY + P L+NNR+KRGLALDGKLKHEDTNLASST++ + NKE LGIIV YKVKV+LV+ G +SD+++ELPFTL HPKP EEP LH + ++P ID +LI+ DT+ DDD++FEDFAR RL G
Sbjct: 32 QLTVYLGKRDFVDHIDVVDPVDGVVLVDPEYLKERKVFVTLTCAFRYGREDLDVLGLTFRKDLFVANIQAFPPVPE---EKKP------LTRLQERLIKKLGEHAYPFTFEIPPNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGPQPMAETTRQFLMSDKPLHLEASLDKEIYYHGEPINVNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAVEEADND--VVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLRDGANKEILGIIVSYKVKVKLVVSRGGLLGDLASSDVAVELPFTLMHPKPT-EEP---------LHREVPENEAP--------------------------IDTNLIEFDTN---------------DDDIVFEDFARQRLKG 414
BLAST of slc6a-8 vs. Ensembl Mouse
Match: Arrb1 (arrestin, beta 1 [Source:MGI Symbol;Acc:MGI:99473]) HSP 1 Score: 473.011 bits (1216), Expect = 1.367e-154 Identity = 252/449 (56.12%), Postives = 313/449 (69.71%), Query Frame = 3
Query: 156 SKVFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFGTSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRLTG 1502
++VFKK+SPNGK+T YLGKRDF+D++D VDPVDGVVL+DP+YLK+R+V+V + AFRYGREDLDVLGLTFRKDL++A+ Q +PP + DK P LTRLQERLIKKLG +A PF FE+P N P SVTLQPGP D GK CGVDYE+K + A+N +EK HKRNSV+L IRK+ YAP++P PQP+AE + F+MS L LEASLDKE YYHGE ISVNV V NN+NKT+KKIKI+VRQ+ADICL+N YKC V E +D + + +CKVY + P L+NNR+KRGLALDGKLKHEDTNLASST++ E N+E LGIIV YKVKV+LV+ G D+++ELPFTL HPKP +E P H + ++P +D +LI+LDT+ DDD++FEDFAR RL G
Sbjct: 6 TRVFKKASPNGKLTVYLGKRDFVDHIDLVDPVDGVVLVDPEYLKERRVYVTLTCAFRYGREDLDVLGLTFRKDLFVANVQSFPPAPE---DKKP------LTRLQERLIKKLGEHACPFTFEIPPNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGPQPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAMEEADDNV---APSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLVVSRG-GDVAVELPFTLMHPKPKEEPP----------HREVPESETP--------------------------VDTNLIELDTN---------------DDDIVFEDFARQRLKG 390
BLAST of slc6a-8 vs. Ensembl Mouse
Match: Arrb1 (arrestin, beta 1 [Source:MGI Symbol;Acc:MGI:99473]) HSP 1 Score: 473.011 bits (1216), Expect = 1.944e-154 Identity = 253/456 (55.48%), Postives = 315/456 (69.08%), Query Frame = 3
Query: 156 SKVFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFG-------TSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRLTG 1502
++VFKK+SPNGK+T YLGKRDF+D++D VDPVDGVVL+DP+YLK+R+V+V + AFRYGREDLDVLGLTFRKDL++A+ Q +PP + DK P LTRLQERLIKKLG +A PF FE+P N P SVTLQPGP D GK CGVDYE+K + A+N +EK HKRNSV+L IRK+ YAP++P PQP+AE + F+MS L LEASLDKE YYHGE ISVNV V NN+NKT+KKIKI+VRQ+ADICL+N YKC V E +D + + +CKVY + P L+NNR+KRGLALDGKLKHEDTNLASST++ E N+E LGIIV YKVKV+LV+ G +SD+++ELPFTL HPKP +E P H + ++P +D +LI+LDT+ DDD++FEDFAR RL G
Sbjct: 6 TRVFKKASPNGKLTVYLGKRDFVDHIDLVDPVDGVVLVDPEYLKERRVYVTLTCAFRYGREDLDVLGLTFRKDLFVANVQSFPPAPE---DKKP------LTRLQERLIKKLGEHACPFTFEIPPNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGPQPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAMEEADDNV---APSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLVVSRGGLLGDLASSDVAVELPFTLMHPKPKEEPP----------HREVPESETP--------------------------VDTNLIELDTN---------------DDDIVFEDFARQRLKG 398
BLAST of slc6a-8 vs. Ensembl Mouse
Match: Arrb1 (arrestin, beta 1 [Source:MGI Symbol;Acc:MGI:99473]) HSP 1 Score: 471.085 bits (1211), Expect = 7.918e-154 Identity = 253/457 (55.36%), Postives = 314/457 (68.71%), Query Frame = 3
Query: 156 SKVFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVL--------GFGTSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRLTG 1502
++VFKK+SPNGK+T YLGKRDF+D++D VDPVDGVVL+DP+YLK+R+V+V + AFRYGREDLDVLGLTFRKDL++A+ Q +PP + DK P LTRLQERLIKKLG +A PF FE+P N P SVTLQPGP D GK CGVDYE+K + A+N +EK HKRNSV+L IRK+ YAP++P PQP+AE + F+MS L LEASLDKE YYHGE ISVNV V NN+NKT+KKIKI+VRQ+ADICL+N YKC V E +D + + +CKVY + P L+NNR+KRGLALDGKLKHEDTNLASST++ E N+E LGIIV YKVKV+LV+ G SD+++ELPFTL HPKP +E P H + ++P +D +LI+LDT+ DDD++FEDFAR RL G
Sbjct: 6 TRVFKKASPNGKLTVYLGKRDFVDHIDLVDPVDGVVLVDPEYLKERRVYVTLTCAFRYGREDLDVLGLTFRKDLFVANVQSFPPAPE---DKKP------LTRLQERLIKKLGEHACPFTFEIPPNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGPQPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAMEEADDNV---APSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLVVSRGGLAGRGVCFSDVAVELPFTLMHPKPKEEPP----------HREVPESETP--------------------------VDTNLIELDTN---------------DDDIVFEDFARQRLKG 399
BLAST of slc6a-8 vs. Ensembl Mouse
Match: Arrb2 (arrestin, beta 2 [Source:MGI Symbol;Acc:MGI:99474]) HSP 1 Score: 460.685 bits (1184), Expect = 9.006e-150 Identity = 250/462 (54.11%), Postives = 317/462 (68.61%), Query Frame = 3
Query: 144 EKETSKVFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMS-PGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFGTSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEI---ISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRLTGGDKND 1517
EK ++VFKKSSPN K+T YLGKRDF+D+LD VDPVDGVVL+DPDYLKDRKVFV + AFRYGREDLDVLGL+FRKDL++A+ Q + R TRLQ+RL+KKLG +A+PF+F +P N P SVTLQPGP D GK CGVD+E++ + A + +EK+HKRNSV+L IRK+ +AP+ P PQPSAE + F+MS SL LEASLDKE YYHGE ++VNV V NNS KT+KKI+++VRQ+ADICL++ YKC V +LE +D S + +CKVY + PLLS+NR+KRGLALDG+LKHEDTNLASSTI+ E NKE LGI+V Y+VKV+LV+ G D+S+ELPF L HPKP D H + QS I + E++VP +D +LI+ DT+ + DDD++FEDFARLRL G +D
Sbjct: 3 EKPGTRVFKKSSPNCKLTVYLGKRDFVDHLDKVDPVDGVVLVDPDYLKDRKVFVTLTCAFRYGREDLDVLGLSFRKDLFIATYQAF---------PPMPNPPRPPTRLQDRLLKKLGQHAHPFFFTIPQNLPCSVTLQPGPEDTGKACGVDFEIRAFCAKSIEEKSHKRNSVRLIIRKVQFAPETPGPQPSAETTRHFLMSDRRSLHLEASLDKELYYHGEPLNVNVHVTNNSAKTVKKIRVSVRQYADICLFSTAQYKCPVAQLEQDDQV---SPSSTFCKVYTITPLLSDNREKRGLALDGQLKHEDTNLASSTIVKEGANKEVLGILVSYRVKVKLVVSRG-GDVSVELPFVLMHPKPHD-------------HITLPRPQSAPIHPPLLCPSAPRETDVP-----------VDTNLIEFDTN------------YATDDDIVFEDFARLRLKGMKDDD 415
BLAST of slc6a-8 vs. Ensembl Mouse
Match: Arrb2 (arrestin, beta 2 [Source:MGI Symbol;Acc:MGI:99474]) HSP 1 Score: 460.685 bits (1184), Expect = 9.006e-150 Identity = 250/462 (54.11%), Postives = 317/462 (68.61%), Query Frame = 3
Query: 144 EKETSKVFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMS-PGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFGTSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEI---ISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRLTGGDKND 1517
EK ++VFKKSSPN K+T YLGKRDF+D+LD VDPVDGVVL+DPDYLKDRKVFV + AFRYGREDLDVLGL+FRKDL++A+ Q + R TRLQ+RL+KKLG +A+PF+F +P N P SVTLQPGP D GK CGVD+E++ + A + +EK+HKRNSV+L IRK+ +AP+ P PQPSAE + F+MS SL LEASLDKE YYHGE ++VNV V NNS KT+KKI+++VRQ+ADICL++ YKC V +LE +D S + +CKVY + PLLS+NR+KRGLALDG+LKHEDTNLASSTI+ E NKE LGI+V Y+VKV+LV+ G D+S+ELPF L HPKP D H + QS I + E++VP +D +LI+ DT+ + DDD++FEDFARLRL G +D
Sbjct: 3 EKPGTRVFKKSSPNCKLTVYLGKRDFVDHLDKVDPVDGVVLVDPDYLKDRKVFVTLTCAFRYGREDLDVLGLSFRKDLFIATYQAF---------PPMPNPPRPPTRLQDRLLKKLGQHAHPFFFTIPQNLPCSVTLQPGPEDTGKACGVDFEIRAFCAKSIEEKSHKRNSVRLIIRKVQFAPETPGPQPSAETTRHFLMSDRRSLHLEASLDKELYYHGEPLNVNVHVTNNSAKTVKKIRVSVRQYADICLFSTAQYKCPVAQLEQDDQV---SPSSTFCKVYTITPLLSDNREKRGLALDGQLKHEDTNLASSTIVKEGANKEVLGILVSYRVKVKLVVSRG-GDVSVELPFVLMHPKPHD-------------HITLPRPQSAPIHPPLLCPSAPRETDVP-----------VDTNLIEFDTN------------YATDDDIVFEDFARLRLKGMKDDD 415
BLAST of slc6a-8 vs. UniProt/SwissProt
Match: sp|Q4R562|ARRB1_MACFA (Beta-arrestin-1 OS=Macaca fascicularis OX=9541 GN=ARRB1 PE=2 SV=1) HSP 1 Score: 476.863 bits (1226), Expect = 3.277e-155 Identity = 256/449 (57.02%), Postives = 315/449 (70.16%), Query Frame = 3
Query: 156 SKVFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFGTSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRLTG 1502
++VFKK+SPNGK+T YLGKRDF+D++D VDPVDGVVL+DP+YLK+R+V+V + AFRYGREDLDVLGLTFRKDL++A+ Q +PP + DK P LTRLQERLIKKLG +AYPF FE+P N P SVTLQPGP D GK CGVDYE+K + A+N +EK HKRNSV+L IRK+ YAP++P PQP+AE + F+MS L LEASLDKE YYHGE ISVNV V NN+NKT+KKIKI+VRQ+ADICL+N YKC V E +D + + +CKVY + P L+NNR+KRGLALDGKLKHEDTNLASST++ E N+E LGIIV YKVKV+LV+ G D+++ELPFTL HPKP EEP LH + Q+P +D +LI+LDT+ DDD++FEDFAR RL G
Sbjct: 6 TRVFKKASPNGKLTVYLGKRDFVDHIDLVDPVDGVVLVDPEYLKERRVYVTLTCAFRYGREDLDVLGLTFRKDLFVANVQSFPPAPE---DKKP------LTRLQERLIKKLGEHAYPFTFEIPPNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGPQPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAMEEADD---TVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLVVSRG-GDVAVELPFTLMHPKPK-EEP---------LHREVPENQTP--------------------------VDTNLIELDTN---------------DDDIVFEDFARQRLKG 390
BLAST of slc6a-8 vs. UniProt/SwissProt
Match: sp|P29066|ARRB1_RAT (Beta-arrestin-1 OS=Rattus norvegicus OX=10116 GN=Arrb1 PE=1 SV=1) HSP 1 Score: 475.707 bits (1223), Expect = 9.454e-155 Identity = 254/456 (55.70%), Postives = 316/456 (69.30%), Query Frame = 3
Query: 156 SKVFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFG-------TSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRLTG 1502
++VFKK+SPNGK+T YLGKRDF+D++D VDPVDGVVL+DP+YLK+R+V+V + AFRYGREDLDVLGLTFRKDL++A+ Q +PP + DK P LTRLQERLIKKLG +AYPF FE+P N P SVTLQPGP D GK CGVDYE+K + A+N +EK HKRNSV+L IRK+ YAP++P PQP+AE + F+MS L LEASLDKE YYHGE ISVNV V NN+NKT+KKIKI+VRQ+ADICL+N YKC V E +D + + +CKVY + P L+NNR+KRGLALDGKLKHEDTNLASST++ E N+E LGIIV YKVKV+LV+ G +SD+++ELPFTL HPKP +E P H + ++P +D +LI+LDT+ DDD++FEDFAR RL G
Sbjct: 6 TRVFKKASPNGKLTVYLGKRDFVDHIDLVDPVDGVVLVDPEYLKERRVYVTLTCAFRYGREDLDVLGLTFRKDLFVANVQSFPPAPE---DKKP------LTRLQERLIKKLGEHAYPFTFEIPPNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGPQPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAMEEADD---TVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLVVSRGGLLGDLASSDVAVELPFTLMHPKPKEEPP----------HREVPESETP--------------------------VDTNLIELDTN---------------DDDIVFEDFARQRLKG 398
BLAST of slc6a-8 vs. UniProt/SwissProt
Match: sp|P49407|ARRB1_HUMAN (Beta-arrestin-1 OS=Homo sapiens OX=9606 GN=ARRB1 PE=1 SV=2) HSP 1 Score: 475.707 bits (1223), Expect = 1.073e-154 Identity = 254/456 (55.70%), Postives = 316/456 (69.30%), Query Frame = 3
Query: 156 SKVFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFG-------TSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRLTG 1502
++VFKK+SPNGK+T YLGKRDF+D++D VDPVDGVVL+DP+YLK+R+V+V + AFRYGREDLDVLGLTFRKDL++A+ Q +PP + DK P LTRLQERLIKKLG +AYPF FE+P N P SVTLQPGP D GK CGVDYE+K + A+N +EK HKRNSV+L IRK+ YAP++P PQP+AE + F+MS L LEASLDKE YYHGE ISVNV V NN+NKT+KKIKI+VRQ+ADICL+N YKC V E +D + + +CKVY + P L+NNR+KRGLALDGKLKHEDTNLASST++ E N+E LGIIV YKVKV+LV+ G +SD+++ELPFTL HPKP +E P H + ++P +D +LI+LDT+ DDD++FEDFAR RL G
Sbjct: 6 TRVFKKASPNGKLTVYLGKRDFVDHIDLVDPVDGVVLVDPEYLKERRVYVTLTCAFRYGREDLDVLGLTFRKDLFVANVQSFPPAPE---DKKP------LTRLQERLIKKLGEHAYPFTFEIPPNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGPQPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAMEEADD---TVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLVVSRGGLLGDLASSDVAVELPFTLMHPKPKEEPP----------HREVPENETP--------------------------VDTNLIELDTN---------------DDDIVFEDFARQRLKG 398
BLAST of slc6a-8 vs. UniProt/SwissProt
Match: sp|P17870|ARRB1_BOVIN (Beta-arrestin-1 OS=Bos taurus OX=9913 GN=ARRB1 PE=1 SV=1) HSP 1 Score: 474.552 bits (1220), Expect = 2.573e-154 Identity = 253/456 (55.48%), Postives = 316/456 (69.30%), Query Frame = 3
Query: 156 SKVFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFG-------TSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRLTG 1502
++VFKK+SPNGK+T YLGKRDF+D++D V+PVDGVVL+DP+YLK+R+V+V + AFRYGREDLDVLGLTFRKDL++A+ Q +PP + DK P LTRLQERLIKKLG +AYPF FE+P N P SVTLQPGP D GK CGVDYE+K + A+N +EK HKRNSV+L IRK+ YAP++P PQP+AE + F+MS L LEASLDKE YYHGE ISVNV V NN+NKT+KKIKI+VRQ+ADICL+N YKC V E +D + + +CKVY + P L+NNR+KRGLALDGKLKHEDTNLASST++ E N+E LGIIV YKVKV+LV+ G +SD+++ELPFTL HPKP +E P H + ++P +D +LI+LDT+ DDD++FEDFAR RL G
Sbjct: 6 TRVFKKASPNGKLTVYLGKRDFVDHIDLVEPVDGVVLVDPEYLKERRVYVTLTCAFRYGREDLDVLGLTFRKDLFVANVQSFPPAPE---DKKP------LTRLQERLIKKLGEHAYPFTFEIPPNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGPQPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAMEEADD---TVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLVVSRGGLLGDLASSDVAVELPFTLMHPKPKEEPP----------HREVPEHETP--------------------------VDTNLIELDTN---------------DDDIVFEDFARQRLKG 398
BLAST of slc6a-8 vs. UniProt/SwissProt
Match: sp|Q8BWG8|ARRB1_MOUSE (Beta-arrestin-1 OS=Mus musculus OX=10090 GN=Arrb1 PE=1 SV=1) HSP 1 Score: 473.011 bits (1216), Expect = 1.360e-153 Identity = 253/456 (55.48%), Postives = 315/456 (69.08%), Query Frame = 3
Query: 156 SKVFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFG-------TSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRLTG 1502
++VFKK+SPNGK+T YLGKRDF+D++D VDPVDGVVL+DP+YLK+R+V+V + AFRYGREDLDVLGLTFRKDL++A+ Q +PP + DK P LTRLQERLIKKLG +A PF FE+P N P SVTLQPGP D GK CGVDYE+K + A+N +EK HKRNSV+L IRK+ YAP++P PQP+AE + F+MS L LEASLDKE YYHGE ISVNV V NN+NKT+KKIKI+VRQ+ADICL+N YKC V E +D + + +CKVY + P L+NNR+KRGLALDGKLKHEDTNLASST++ E N+E LGIIV YKVKV+LV+ G +SD+++ELPFTL HPKP +E P H + ++P +D +LI+LDT+ DDD++FEDFAR RL G
Sbjct: 6 TRVFKKASPNGKLTVYLGKRDFVDHIDLVDPVDGVVLVDPEYLKERRVYVTLTCAFRYGREDLDVLGLTFRKDLFVANVQSFPPAPE---DKKP------LTRLQERLIKKLGEHACPFTFEIPPNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGPQPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAMEEADDNV---APSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLVVSRGGLLGDLASSDVAVELPFTLMHPKPKEEPP----------HREVPESETP--------------------------VDTNLIELDTN---------------DDDIVFEDFARQRLKG 398
BLAST of slc6a-8 vs. TrEMBL
Match: A0A0H3YK12 (Slc6a-8 OS=Schmidtea mediterranea OX=79327 GN=slc6a-8 PE=2 SV=1) HSP 1 Score: 825.083 bits (2130), Expect = 0.000e+0 Identity = 435/435 (100.00%), Postives = 435/435 (100.00%), Query Frame = 2
Query: 1874 MQNIELNESKLIKSHXXXXXXXXXXCRTIALLAENSDESKNLENHSDPQTRKHWASQLDFLFSIIGFAVDFSNVFRFPYICFQNGGGAFLIPYFVTLLLCALPMFYIELLFGQYMRCGGLTIWKICPLFKGVGYASVLLNFYVALYYNVIIAWSLYYLFVSFSPTLPWTVCDKWWNSENCYFISNYLSLLEKNNNTNMFTDSATEYLENNVLMVNQSSGIGNLGPLKWNMAXXXXXXXXXXXXXXFKGVKFLGKAVWVTAILPYVVLAALLIRGVMLEGAVEGIKYFITPNFKMLLKPDVWIAAATQIFFSVGVGFSVHIAYASYNNFHTPVHNNCLIAAAVNSLTSLFSGFVIFAYLGYMSHQMRKPLEKVVNGNLTLIFIVYPLALSTLPGGNFWAVIFFLMLFNLGLDSSVRASIILNFELIYFSSEPLKLY 3178
MQNIELNESKLIKSHNNINNENPSNCRTIALLAENSDESKNLENHSDPQTRKHWASQLDFLFSIIGFAVDFSNVFRFPYICFQNGGGAFLIPYFVTLLLCALPMFYIELLFGQYMRCGGLTIWKICPLFKGVGYASVLLNFYVALYYNVIIAWSLYYLFVSFSPTLPWTVCDKWWNSENCYFISNYLSLLEKNNNTNMFTDSATEYLENNVLMVNQSSGIGNLGPLKWNMALSLLLLYIIIYLCLFKGVKFLGKAVWVTAILPYVVLAALLIRGVMLEGAVEGIKYFITPNFKMLLKPDVWIAAATQIFFSVGVGFSVHIAYASYNNFHTPVHNNCLIAAAVNSLTSLFSGFVIFAYLGYMSHQMRKPLEKVVNGNLTLIFIVYPLALSTLPGGNFWAVIFFLMLFNLGLDSSVRASIILNFELIYFSSEPLKLY
Sbjct: 1 MQNIELNESKLIKSHNNINNENPSNCRTIALLAENSDESKNLENHSDPQTRKHWASQLDFLFSIIGFAVDFSNVFRFPYICFQNGGGAFLIPYFVTLLLCALPMFYIELLFGQYMRCGGLTIWKICPLFKGVGYASVLLNFYVALYYNVIIAWSLYYLFVSFSPTLPWTVCDKWWNSENCYFISNYLSLLEKNNNTNMFTDSATEYLENNVLMVNQSSGIGNLGPLKWNMALSLLLLYIIIYLCLFKGVKFLGKAVWVTAILPYVVLAALLIRGVMLEGAVEGIKYFITPNFKMLLKPDVWIAAATQIFFSVGVGFSVHIAYASYNNFHTPVHNNCLIAAAVNSLTSLFSGFVIFAYLGYMSHQMRKPLEKVVNGNLTLIFIVYPLALSTLPGGNFWAVIFFLMLFNLGLDSSVRASIILNFELIYFSSEPLKLY 435
BLAST of slc6a-8 vs. TrEMBL
Match: A0A1I8FTU6 (Arrestin_C domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig004557g1 PE=4 SV=1) HSP 1 Score: 587.415 bits (1513), Expect = 0.000e+0 Identity = 304/481 (63.20%), Postives = 362/481 (75.26%), Query Frame = 3
Query: 93 NNHDVDLDDI----KKQGTSKEKETSKVFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELP-HNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENT-NKENLGIIVQYKVKVRLVLGFGTSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRLTGGDKND 1517
NN DV+ K Q +++ ++VFKKSSPNGKITAYLGKRDF+D+L +VDP+DGVVL+DPDY+KDRKV+ HVLAAFRYGREDLDVLGLTFRKDLY+A QVYPP+ + + LTRLQERLIKKLG NA+PF+FELP +PASVTLQPGPND+GKPCGVDYELKTYVA+ D K+HKR++V+LAIRKLTYAP++P PQPSAE K+FIMS G LRLEASLDKEKYYHGESI++NVLVDNN++KT+KK++I+VRQ ADICL++ SYKC V ELE E+GFPI SQTGWCKVY VCPLL+NNRDKRGLALDG+LKHEDTNLASSTI+ + + +KENLGI+V Y+VKVRLVLGFG+SD+ +ELPF L+HPKP + EDL S + T +DS I+D DLI LD D + L DDDLIFEDFARLRL G + D
Sbjct: 21 NNGDVNQSSTDPSAKSQQAQSQRQGTRVFKKSSPNGKITAYLGKRDFVDHLTHVDPIDGVVLVDPDYMKDRKVYAHVLAAFRYGREDLDVLGLTFRKDLYIACMQVYPPIKD---------NAKPLTRLQERLIKKLGDNAHPFFFELPPQQSPASVTLQPGPNDSGKPCGVDYELKTYVAETADGKSHKRSTVRLAIRKLTYAPEQPGPQPSAETTKEFIMSAGCLRLEASLDKEKYYHGESIAINVLVDNNTSKTVKKVRISVRQIADICLFSPNSYKCGVAELESEEGFPIGPSQTGWCKVYHVCPLLANNRDKRGLALDGQLKHEDTNLASSTILKDASQSKENLGIVVNYRVKVRLVLGFGSSDVCVELPFVLTHPKPCE----------EDL-SEAGDAPAAASAGSTSKAAAPEPAAAAAAAADSDILDTDLIHLDAGSDGARSLH----LHPDDDLIFEDFARLRLQGHGEED 477
BLAST of slc6a-8 vs. TrEMBL
Match: A0A1I8J0I0 (Arrestin_C domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig010879g1 PE=4 SV=1) HSP 1 Score: 587.03 bits (1512), Expect = 0.000e+0 Identity = 304/481 (63.20%), Postives = 362/481 (75.26%), Query Frame = 3
Query: 93 NNHDVDLDDI----KKQGTSKEKETSKVFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELP-HNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENT-NKENLGIIVQYKVKVRLVLGFGTSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRLTGGDKND 1517
NN DV+ K Q +++ ++VFKKSSPNGKITAYLGKRDF+D+L +VDP+DGVVL+DPDY+KDRKV+ HVLAAFRYGREDLDVLGLTFRKDLY+A QVYPP+ + + LTRLQERLIKKLG NA+PF+FELP +PASVTLQPGPND+GKPCGVDYELKTYVA+ D K+HKR++V+LAIRKLTYAP++P PQPSAE K+FIMS G LRLEASLDKEKYYHGESI++NVLVDNN++KT+KK++I+VRQ ADICL++ SYKC V ELE E+GFPI SQTGWCKVY VCPLL+NNRDKRGLALDG+LKHEDTNLASSTI+ + + +KENLGI+V Y+VKVRLVLGFG+SD+ +ELPF L+HPKP + EDL S + T +DS I+D DLI LD D + L DDDLIFEDFARLRL G + D
Sbjct: 21 NNGDVNQSSTDPSAKTQQAQSQRQGTRVFKKSSPNGKITAYLGKRDFVDHLTHVDPIDGVVLVDPDYMKDRKVYAHVLAAFRYGREDLDVLGLTFRKDLYIACMQVYPPIKD---------NAKPLTRLQERLIKKLGDNAHPFFFELPPQQSPASVTLQPGPNDSGKPCGVDYELKTYVAETADGKSHKRSTVRLAIRKLTYAPEQPGPQPSAETTKEFIMSAGCLRLEASLDKEKYYHGESIAINVLVDNNTSKTVKKVRISVRQIADICLFSPNSYKCGVAELESEEGFPIGPSQTGWCKVYHVCPLLANNRDKRGLALDGQLKHEDTNLASSTILKDASQSKENLGIVVNYRVKVRLVLGFGSSDVCVELPFVLTHPKPCE----------EDL-SEAGDAPAAASAGSTSKAAAPEPAAAAAAAADSDILDTDLIHLDAGSDGARSLH----LHPDDDLIFEDFARLRLQGHGEED 477
BLAST of slc6a-8 vs. TrEMBL
Match: A0A1V1FN69 (Beta-arrestin OS=Ambigolimax valentianus OX=1338344 PE=2 SV=1) HSP 1 Score: 582.408 bits (1500), Expect = 0.000e+0 Identity = 299/469 (63.75%), Postives = 353/469 (75.27%), Query Frame = 3
Query: 114 DDIKKQGTSKEKETSKVFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFGTSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILS-ADDDLIFEDFARLRLTGGDKND 1517
D KKQGT +VFKKS PNGK+T YLGKRDFID+L ++DP+DGV+L+DPDYLKDRKVF H+LAAFRYGREDLDVLGLTFRKDLYL+S QVYPP+ + ++ LTRLQERLIKKLG NAYPF+FELP N+PASVTLQP P D GKPCGVDYELKT+VADN DEK HKRNSV+LAIRKLTYAP++P+PQP+AE +KDFIMSPGS+RLEASLDKEKYYHGESI++NVLVDNN+NKT+KKIKI+VRQ ADICL++ YKC V +LE E+GFPI SSQTG+CKV+ + PLLSNNRDKRGLALDGKLKHEDTNLASSTI+ E + KE+LGI+V Y+VKV+L++GF + ++++ELPFTL+HPKP D S + S P E D +LIQLD TN E DDD IFEDFARLRL G + +D
Sbjct: 17 DQQKKQGT-------RVFKKSCPNGKVTTYLGKRDFIDHLSHIDPIDGVILVDPDYLKDRKVFAHILAAFRYGREDLDVLGLTFRKDLYLSSMQVYPPVKDSK-------ESKPLTRLQERLIKKLGPNAYPFFFELPPNSPASVTLQPAPGDTGKPCGVDYELKTFVADNIDEKPHKRNSVRLAIRKLTYAPEEPAPQPNAEALKDFIMSPGSMRLEASLDKEKYYHGESIAINVLVDNNTNKTVKKIKISVRQFADICLFSTAQYKCTVADLESEEGFPIQSSQTGFCKVFHMTPLLSNNRDKRGLALDGKLKHEDTNLASSTIMTEKSQKESLGIVVSYRVKVKLIMGFTSGELAVELPFTLTHPKPPD--------------------------SPAPSRSASTAPP----EGGDASFDTNLIQLD--------TNGEAFYGDKDDDFIFEDFARLRLKGHEGDD 433
BLAST of slc6a-8 vs. TrEMBL
Match: A0A2T7NC68 (Arrestin_C domain-containing protein OS=Pomacea canaliculata OX=400727 GN=C0Q70_21283 PE=4 SV=1) HSP 1 Score: 580.482 bits (1495), Expect = 0.000e+0 Identity = 299/454 (65.86%), Postives = 351/454 (77.31%), Query Frame = 3
Query: 162 VFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRK-LTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFGTSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILS-ADDDLIFEDFARLRLTGGDKND 1517
VFKKSSPNGKIT YLGKRDFID+L ++DP+DGVVL+DP+YLKDRKV+ H+LAAFRYGREDLDVLGLTFRKDLYL+S QVYPP+ D S K LTRLQERLIKKLG NAYPFYFELP N PASVTLQP P D GKPCGVDYELKTYVADN DEK HKRNSV+LAIRKLTYAP++P+PQPSAE VKDF+MSPGS+RLEASLDKEKYYHGESI++NVLVDNN+NKT+KK+K++VRQ ADICL++ YKC V E+E E+GFPI SQTG+CKVY +CPLL+NNRDKRGLALDGKLKHEDTNLASSTI+ E + KENLGI+V Y+VKV+L+LGFG+ D+S+ELPFTL+HPKP + P + ++++P +D +LI+LD TN E + DDD IFEDFARLRL G + +D
Sbjct: 183 VFKKSSPNGKITTYLGKRDFIDHLTHIDPIDGVVLVDPEYLKDRKVYAHILAAFRYGREDLDVLGLTFRKDLYLSSMQVYPPVK--------DHSEPKPLTRLQERLIKKLGPNAYPFYFELPPNAPASVTLQPAPGDTGKPCGVDYELKTYVADNVDEKPHKRNSVRLAIRKLTYAPEEPAPQPSAEAVKDFMMSPGSIRLEASLDKEKYYHGESIALNVLVDNNTNKTVKKVKLSVRQFADICLFSTAQYKCTVAEMESEEGFPIQPSQTGFCKVYHLCPLLTNNRDKRGLALDGKLKHEDTNLASSTIMTEKSQKENLGIVVSYRVKVKLILGFGSGDLSVELPFTLTHPKPIESPPPSRPPS-----MVPPEVETP--------------------------VDANLIKLD--------TNGEPFYADKDDDFIFEDFARLRLKGHEGDD 589
BLAST of slc6a-8 vs. Ensembl Cavefish
Match: arrb2a (arrestin red cell [Source:NCBI gene;Acc:103028079]) HSP 1 Score: 474.167 bits (1219), Expect = 4.138e-155 Identity = 249/460 (54.13%), Postives = 314/460 (68.26%), Query Frame = 3
Query: 144 EKETSKVFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFG-------TSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRLTG 1502
+K ++VFKKSSPN KIT YLGKRDF+D+LD VDPVDGV+L+DP+YLKDRKVFV + AFRYGREDLDVLGL+FRKDLY+++ Q +PP+ + ++ P+ +RLQERL+KKLG A+PF+F +P N P SVTLQPGP D GK CGVDYE++ + A + +EK HKRNSV+L IRK+ YAP+KP PQP E + F+MS SL LEASLDKE YYHGE ISVNV V NNS KT+K++KI+VRQ+ADICL++ YKC V ++E +D SS + +CKVY + P L+NNR+KRGLALDGKLKHEDTNLASSTI+ E NKE LG++V Y+VKV+LV+ G D+S+ELPF L HPKP DL +++ PE+ D N LI+ +T N + DDDL+FEDFARLRL G
Sbjct: 3 DKAGTRVFKKSSPNCKITVYLGKRDFVDHLDQVDPVDGVILVDPEYLKDRKVFVTLTCAFRYGREDLDVLGLSFRKDLYISTFQAFPPIQE---ERKPN------SRLQERLLKKLGQQAHPFHFTIPQNLPCSVTLQPGPEDTGKACGVDYEIRAFCARSVEEKIHKRNSVRLVIRKVQYAPEKPGPQPMVETTRSFLMSDRSLHLEASLDKELYYHGEPISVNVHVTNNSTKTVKRVKISVRQYADICLFSTAQYKCPVAQIEADDQV---SSSSTFCKVYTLTPTLNNNREKRGLALDGKLKHEDTNLASSTIVKEGCNKEVLGVLVSYRVKVKLVVSRGGLLSSLLERDVSVELPFVLMHPKPI------------DLSTSRPASAVPEVDPPIDTN---------------------LIEFET-----------NSFAQDDDLVFEDFARLRLKG 406
BLAST of slc6a-8 vs. Ensembl Cavefish
Match: arrb1 (arrestin, beta 1 [Source:ZFIN;Acc:ZDB-GENE-060824-1]) HSP 1 Score: 464.537 bits (1194), Expect = 4.651e-152 Identity = 232/358 (64.80%), Postives = 281/358 (78.49%), Query Frame = 3
Query: 159 KVFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFGTSDISLELPFTLSHPKPADE 1232
+VFKK+SPNGK+T YLGKRDF+D++D V+PVDGVVLIDP+YLK+RKVFV + AFRYGREDLDVLGLTFRKDL++A+ Q +PP+ + + LTRLQERLIKKLG +AYPF FE+P N P SVTLQPGP D GK CGVD+E+K + A+N +EK HKRNSV+L IRK+ YAP+KP PQP AE + F+MS L LEASLDKE YYHGE ISVNV V NN+NKT+KK+KI+VRQ+ADICL+N YKC V E +D I + +CKVY + P L+NNR+KRGLALDGKLKHEDTNLASST++ E NKE LGIIV YKVKV+LV+ G D+++ELPFTL HPKP +E
Sbjct: 17 RVFKKASPNGKLTVYLGKRDFVDHVDLVEPVDGVVLIDPEYLKERKVFVTLTCAFRYGREDLDVLGLTFRKDLFVANIQAFPPVPE---------EKKGLTRLQERLIKKLGEHAYPFTFEIPPNLPCSVTLQPGPEDTGKACGVDFEVKAFCAENVEEKIHKRNSVRLIIRKVQYAPEKPGPQPMAETTRQFLMSDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKMKISVRQYADICLFNTAQYKCPVATEESDD---IVAPSATFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLREGANKEILGIIVSYKVKVKLVVSRG-GDVAVELPFTLMHPKPVEE 361
BLAST of slc6a-8 vs. Ensembl Cavefish
Match: arrb2a (arrestin red cell [Source:NCBI gene;Acc:103028079]) HSP 1 Score: 458.373 bits (1178), Expect = 1.109e-148 Identity = 250/489 (51.12%), Postives = 317/489 (64.83%), Query Frame = 3
Query: 144 EKETSKVFKKSSPNGK------------------------------------ITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFGTSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRLTG 1502
+K ++VFKKSSPN K IT YLGKRDF+D+LD VDPVDGV+L+DP+YLKDRKVFV + AFRYGREDLDVLGL+FRKDLY+++ Q +PP+ + ++ P+ +RLQERL+KKLG A+PF+F +P N P SVTLQPGP D GK CGVDYE++ + A + +EK HKRNSV+L IRK+ YAP+KP PQP E + F+MS SL LEASLDKE YYHGE ISVNV V NNS KT+K++KI+VRQ+ADICL++ YKC V ++E +D SS + +CKVY + P L+NNR+KRGLALDGKLKHEDTNLASSTI+ E NKE LG++V Y+VKV+LV+ G D+S+ELPF L HPKP DL +++ PE+ + P ID +LI+ +T N + DDDL+FEDFARLRL G
Sbjct: 3 DKAGTRVFKKSSPNCKVNFTAYFQFFFEHLSLFLFVIVFIMHELIMHSVLFQITVYLGKRDFVDHLDQVDPVDGVILVDPEYLKDRKVFVTLTCAFRYGREDLDVLGLSFRKDLYISTFQAFPPIQE---ERKPN------SRLQERLLKKLGQQAHPFHFTIPQNLPCSVTLQPGPEDTGKACGVDYEIRAFCARSVEEKIHKRNSVRLVIRKVQYAPEKPGPQPMVETTRSFLMSDRSLHLEASLDKELYYHGEPISVNVHVTNNSTKTVKRVKISVRQYADICLFSTAQYKCPVAQIEADDQ---VSSSSTFCKVYTLTPTLNNNREKRGLALDGKLKHEDTNLASSTIVKEGCNKEVLGVLVSYRVKVKLVVSRG-GDVSVELPFVLMHPKPI------------DLSTSRPASAVPEV----------DPP-----------IDTNLIEFET-----------NSFAQDDDLVFEDFARLRLKG 434
BLAST of slc6a-8 vs. Ensembl Cavefish
Match: arrb2b (arrestin, beta 2b [Source:ZFIN;Acc:ZDB-GENE-040426-1332]) HSP 1 Score: 432.95 bits (1112), Expect = 6.222e-140 Identity = 217/358 (60.61%), Postives = 275/358 (76.82%), Query Frame = 3
Query: 159 KVFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFGTSDISLELPFTLSHPKPADE 1232
+VFKKSSPN K+T YLGKRDF+D+LD+VDPVDGV+LIDP+YLKDRKVFV + AFRYGREDLDVLGL+FRKDLY+++ Q +PPL + ++ L+RLQERL+KKLG +A+PF F +P N P SVTLQPGP D GK CGVD+E++ + A + +EK HKR V+ YAP+KP PQP E + F+MS SL LEASLDKE YYHGE ISVNV V NNS KT+K++KI+VRQ+ADICL++ YKC V ++E +D S + +CKVY + P L+NNR+KRGLALDGKLKHEDTNLASSTI+ + +NKE LGI+V Y+VKV+LV+ G D+S+ELPF L HPKP+++
Sbjct: 8 RVFKKSSPNCKLTVYLGKRDFVDHLDHVDPVDGVLLIDPEYLKDRKVFVTLTCAFRYGREDLDVLGLSFRKDLYISTFQAFPPLPE---------EHKPLSRLQERLLKKLGQHAHPFNFTIPQNLPCSVTLQPGPEDTGKACGVDFEIRAFCAKSVEEKIHKRCRVQ-------YAPEKPGPQPMVETTRSFLMSDRSLHLEASLDKELYYHGEPISVNVHVTNNSTKTVKRVKISVRQYADICLFSTAQYKCPVAQVEADDQV---SPSSTFCKVYTLTPTLNNNREKRGLALDGKLKHEDTNLASSTIVKDVSNKEVLGILVSYRVKVKLVVSRG-GDVSVELPFVLMHPKPSEQ 345
BLAST of slc6a-8 vs. Ensembl Cavefish
Match: slc6a3 (solute carrier family 6 member 3 [Source:NCBI gene;Acc:103026128]) HSP 1 Score: 379.407 bits (973), Expect = 8.296e-117 Identity = 192/404 (47.52%), Postives = 266/404 (65.84%), Query Frame = 2
Query: 2000 ENHSDPQTRKHWASQLDFLFSIIGFAVDFSNVFRFPYICFQNGGGAFLIPYFVTLLLCALPMFYIELLFGQYMRCGGLTIWKICPLFKGVGYASVLLNFYVALYYNVIIAWSLYYLFVSFSPTLPWTVCDKWWNSENCYFISNYLSLLEKNNNTNMFTDS-----ATEYLENNVLMVNQSSGIGNLGPLKWNMAXXXXXXXXXXXXXXFKGVKFLGKAVWVTAILPYVVLAALLIRGVMLEGAVEGIKYFITPNFKMLLKPDVWIAAATQIFFSVGVGFSVHIAYASYNNFHTPVHNNCLIAAAVNSLTSLFSGFVIFAYLGYMSHQMRKPLEKVVNGNLTLIFIVYPLALSTLPGGNFWAVIFFLMLFNLGLDS------SVRASIILNFELIYFSSEPLKLY 3178
+ H + R+ W ++DFL S+IGFAVD +NV+RFPY+C++NGGGAFL+PY + +++ +P+FY+EL GQY R G +WKICP+FKGVG+ +L++ YV YYNVIIAW+L+YLF SFS LPW C+ WNS NC + N + DS A EY E VL + S GI +LG +W + L ++ +++Y L+KGVK GK VW+TA +PYVVL LL+RGV L GA++GIK +++ +F L VWI AATQI FS+GVGF V IA++SYN F + + +I +++NSLTS FSGFVIF++LGYMS + L+KV L+FI+YP A++TLPG + WAVIFF+ML LG+DS SV +I F+ ++ E L+
Sbjct: 53 QTHPSGEQRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQYNREGAAGVWKICPVFKGVGFTVILISLYVGFYYNVIIAWALFYLFSSFSGELPWVNCNNTWNSANC-----------SDLNATLLNDSHKVTPALEYFERGVLHMQDSRGIDDLGLPRWQLTCCLAVVIVVLYFSLWKGVKTSGKVVWITATMPYVVLTVLLLRGVTLPGAIDGIKAYLSVDFLRLCDAQVWIEAATQICFSLGVGFGVLIAFSSYNKFSNNCYRDAIITSSINSLTSFFSGFVIFSFLGYMSQKHNVALDKVATDGPGLVFIIYPEAIATLPGSSVWAVIFFIMLLTLGIDSAMGGMESVITGLIDEFKFLHRHRELFTLF 445 HSP 2 Score: 82.0333 bits (201), Expect = 2.422e-15 Identity = 56/206 (27.18%), Postives = 116/206 (56.31%), Query Frame = 1
Query: 3160 GALEALLTGILDEFDFVFKKMKYKREITTAVMLTILYFLSLPNTTYGGFFLIQLYDKYSAGPSLLAVSLLECIGFIWIYGIDNTADIIKQMNGFDLHIIFRILFKYITPFAILAITIAQLFTDEIFTVNLGTRTYTYPQWXXXXXXXXXXXXXXXXXXFGGVVLYRIKATSWKERICLSISPNWEHRDIRSKTQFNRLKINHWITV 3777
G +E+++TG++DEF F+ + RE+ T ++ + + +SL T GG ++ L D ++AG S+L L+E IG W YG+D +D I++M G + +R+ +K+++P +L + + T +Y +P W+ ++G +S+SS++M+P++ + + S+ ++ +I+P EH + + + + ++HW+ V
Sbjct: 419 GGMESVITGLIDEFKFLHRH----RELFTLFIVVLTFLISLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGIAWFYGVDRFSDDIQEMIGHRPGLYWRLCWKFVSPCFLLFMVVVSFATFNPPKYG----SYYFPTWANMVGWCLSISSMIMVPLY-AIYKFCTLPGSFCAKLAYAITPETEHHLVE-RGEVRQFTLHHWLVV 614
BLAST of slc6a-8 vs. Ensembl Sea Lamprey
Match: slc6a1a (solute carrier family 6 member 1a [Source:ZFIN;Acc:ZDB-GENE-060519-23]) HSP 1 Score: 317.005 bits (811), Expect = 9.906e-103 Identity = 166/371 (44.74%), Postives = 246/371 (66.31%), Query Frame = 2
Query: 2003 NHSDPQTRKHWASQLDFLFSIIGFAVDFSNVFRFPYICFQNGGGAFLIPYFVTLLLCALPMFYIELLFGQYMRCGGLTIWKICPLFKGVGYASVLLNFYVALYYNVIIAWSLYYLFVSFSPTLPWTVCDKWWNSENCYFISNYLSLLEKNNNTNMFTDSATEYLENNVLMVNQSSGIGNLGPLKWNMAXXXXXXXXXXXXXXFKGVKFLGKAVWVTAILPYVVLAALLIRGVMLEGAVEGIKYFITPNFKMLLKPDVWIAAATQIFFSVGVGFSVHIAYASYNNFHTPVHN-NCLIAAAVNSLTSLFSGFVIFAYLGYMSHQMRKPLEKVVNGNLTLIFIVYPLALSTLPGGNFWAVIFFLMLFNLGLDSS 3112
+ R W + DFL S +G+A+ NV+RFPY+C +NGGGAFLIPYF+TL+ +P+F +E GQY GGL +WK+ P+FKGVG ASV+++FY+ +YY VII+W++YYL+ SF+ LPW C+ WN++ C+ SNY S+L+ N T + E+ E N M SSG+ G ++ +A++L + ++++Y C++KGV + GK V+ +A PYV+L L RG+ L GA EGI ++ITP+F+ L VW+ AATQIFFS G+G +A SYN FH V+N + +I +NS+TS+F+GFVIF+ +G+MSH +KP++++ L F+ YP A++ LP W+++FF ML LGLDS
Sbjct: 3 KKKELPVRGAWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLVFAGIPLFLLETSLGQYTSVGGLGVWKLAPMFKGVGLASVVISFYLNIYYIVIISWAIYYLYNSFTSMLPWQDCNNPWNTDKCF--SNY-SILDTTN----LTSTVVEFWERN--MHQLSSGLDEPGQVRGPLAITLAISWVMVYFCIWKGVAWTGKVVYFSATFPYVMLFVLFFRGITLPGAKEGILFYITPDFRRLTDSAVWLDAATQIFFSYGLGLGSLVALGSYNPFHNNVYNRDSIIVCCINSVTSVFAGFVIFSIVGFMSHITKKPVKELAASGPGLAFLAYPQAVTQLPISPLWSILFFSMLLMLGLDSQ 364 HSP 2 Score: 76.6406 bits (187), Expect = 9.906e-103 Identity = 47/143 (32.87%), Postives = 77/143 (53.85%), Query Frame = 1
Query: 3154 QFGALEALLTGILDEFDFVFKKMKYKREITTAVMLTILYFLSLPNTTYGGFFLIQLYDKYSA-GPSLLAVSLLECIGFIWIYGIDNTADIIKQMNGFDLHIIFRILFKYITPFAILAITIAQLFTDEIFTVNLGTRTYTYPQW 3579
QF +E +T + DE+ + ++ +EI AV+ I Y + L N T GG ++ +++D YSA G SLL + E I W YG+D D I +M G +H + I + + TP ++ + + + E+ + LG +YTYP W
Sbjct: 364 QFCTVEGFVTALSDEYP---QYLRGHKEIFIAVICVISYIIGLANITQGGLYVFKMFDYYSASGMSLLFLVFFETIAISWCYGVDRFNDNICEMIGHKVHKWWNICWVFFTPLVVVGVFMFSVV--EMTPLTLG--SYTYPMW 499
BLAST of slc6a-8 vs. Ensembl Sea Lamprey
Match: slc6a4b (solute carrier family 6 member 4b [Source:ZFIN;Acc:ZDB-GENE-060314-2]) HSP 1 Score: 292.738 bits (748), Expect = 4.970e-94 Identity = 159/331 (48.04%), Postives = 219/331 (66.16%), Query Frame = 2
Query: 2132 GAFLIPYFVTLLLCALPMFYIELLFGQYMRCGGLTIWK-ICPLFKGVGYASVLLNFYVALYYNVIIAWSLYYLFVSFSPTLPWTVCDKWWNSENC--YFISNYLSLLEKNNNTNMFTDSATEYLENNVLMVNQSSGIGNLGPLKWNMAXXXXXXXXXXXXXXFKGVKFLGKAVWVTAILPYVVLAALLIRGVMLEGAVEGIKYFITPNFKMLLKPDVWIAAATQIFFSVGVGFSVHIAYASYNNFHTPVHNNCLIAAAVNSLTSLFSGFVIFAYLGYMSHQMRKPLEKVVNG-NLTLIFIVYPLALSTLPGGNFWAVIFFLMLFNLGLDSS 3112
GAFLIPY + + +P+FY+EL GQ+ R G ++IW+ ICP+FKGVG+A ++NFYVA YYN IIAW+LYYL+ SF+ TLPWT CD WN+ NC YF + ++ + + + A E+ NVL + S G+G +G L+W + L L L++ I+Y L+KGVK GK VWVTA PYVVL LLIRG L GA G+ +++ PN+K LL +VW+ AA QIFFS+G GF V +A ASYN F+ + + L+ ++VN TS SGFVIF LGYM+ +E V +L+FI YP A++ + G FWA++FF+M+ LGLDS+
Sbjct: 1 GAFLIPYCLMAVFGGIPLFYMELALGQFHRNGAISIWRRICPIFKGVGFAICIINFYVAFYYNTIIAWALYYLYSSFTSTLPWTKCDNPWNTVNCTSYFDTTGVAWGKHSRS------PAEEFYTRNVLEIQYSKGLGGVGGLRWQLLLCLFLIFTIVYFSLWKGVKTSGKVVWVTATFPYVVLFILLIRGATLPGAWRGVLFYLKPNWKKLLTTEVWVDAAAQIFFSLGPGFGVLLALASYNKFNNNCYRDALVTSSVNCFTSFMSGFVIFTVLGYMAEMRNVEVEDVAKDMGPSLLFITYPEAIANMMGSTFWAILFFMMMITLGLDST 325 HSP 2 Score: 72.0182 bits (175), Expect = 4.970e-94 Identity = 42/141 (29.79%), Postives = 74/141 (52.48%), Query Frame = 1
Query: 3157 FGALEALLTGILDEFDFVFKKMKYKREITTAVMLTILYFLSLPNTTYGGFFLIQLYDKYSAGPSLLAVSLLECIGFIWIYGIDNTADIIKQMNGFDLHIIFRILFKYITPFAILAITIAQLFTDEIFTVNLGTRTYTYPQW 3579
FG LEA++T ++DE+ +F K +RE ++TI + +L TYGG ++++L +++ +G S++ + LLE I W YG+ I M GF +R+ + I+P + I ++ L + L Y +P W
Sbjct: 326 FGGLEAIITAVMDEYPSLFSK---RREYFVLGLVTICFMGALSTLTYGGAYIVKLLEEFGSGCSIIGIVLLEAIAVSWFYGVKRFCADIHSMLGFSPGYFWRLCWVAISPLFLSFIVVSFLTGSK----PLKLFDYDFPDW 459
BLAST of slc6a-8 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008631.1 (pep scaffold:Pmarinus_7.0:GL483327:11244:21649:-1 gene:ENSPMAG00000007785.1 transcript:ENSPMAT00000008631.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 226.098 bits (575), Expect = 1.306e-72 Identity = 144/335 (42.99%), Postives = 210/335 (62.69%), Query Frame = 2
Query: 2132 GAFLIPYFVTLLLCALPMFYIELLFGQYMRCGGLTIWKICPLFKGVGYASVLLNFYVALYYNVIIAWSLYYLFVSFSPT-LPWTVCDKWWNSENCYFISNYLSLLEKNNNTNM-------FTDSATEYLENNVLMVNQSSGIGNLGPLKWNMAXXXXXXXXXXXXXXFKGVKFLGKAVWVTAILPYVVLAALLIRGVMLEGAVEGIKYFITPNFKMLLKPDVWIAAATQIFFSVGVGFSVHIAYASYNNFHTPVHNNCLIAAAVNSLTSLFSGFVIFAYLGYMSHQMRKPLEKVVNGNLTLIFIVYPLALSTLPGGNFWAVIFFLMLFNLGLDSS 3112
GAFL+PY +T++ +P+F++E+ GQ + G + +WKI PLF GVG AS+++ F LYY V++AWSLYYL S + LPWT C WW + C S+ L +N + T A E+ E NVL V SSG+ +LG + W M L LL +++++Y ++KG+KF GK V+VT +PYV+L LL++GVML GA++GI Y++ P++ L P VW+ A+TQ+F+ GVGF V A SYN FH + + +I +NS TS FSGFV+F++LG+M+ + + V L+F+VYP A+S LP WA + F+ML LG+DS
Sbjct: 1 GAFLVPYGLTVVCVGIPLFFLEVALGQLTQQGTIGVWKIVPLFTGVGVASMVVVFLSDLYYIVVLAWSLYYLLHSLTTAQLPWTHCQGWWATAAC---SDTLGTSRAASNASEGASACQDTTSPAVEFWERNVLRV--SSGMHDLGSVNWEMLLCLLAVWLLVYFSVWKGIKFSGKVVYVTGSVPYVLLLVLLVQGVMLPGALDGITYYLQPDWAKLATPQVWVEASTQVFYCYGVGFGVLPALGSYNKFHNNCYRDSIILTIINSATSFFSGFVVFSFLGFMAQEQGVDISHVAETGPGLVFVVYPRAISLLPVPALWATLLFIMLLLLGVDSE 330 HSP 2 Score: 67.0106 bits (162), Expect = 1.306e-72 Identity = 43/143 (30.07%), Postives = 65/143 (45.45%), Query Frame = 1
Query: 3154 QFGALEALLTGILDEFDFVFKKMKYKREITTAVMLTILYFLSLPNTTYGGFFLIQLYDKYSA-GPSLLAVSLLECIGFIWIYGIDNTADIIKQMNGFDLHIIFRILFKYITPFAILAITIAQLFTDEIFTVNLGTRTYTYPQW 3579
+F +E +TG+ D F K +RE T + + + LS+ T GG ++ QL+D Y+A G S+L + ECI W+YG + + M GF H + ++P L I + L E N Y YP W
Sbjct: 330 EFAGMEGFVTGLTDLFPSQLSG-KRRREAFTGLCCLVSFLLSVTMVTQGGIYVFQLFDSYAASGISMLWLMGWECIAVAWVYGANRFMQDLTAMLGFRPHAWVWWCWSVVSPAVCLGIFVFHLVHYERLVYN---GRYEYPGW 468
BLAST of slc6a-8 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004302.1 (pep scaffold:Pmarinus_7.0:GL490722:800:6194:-1 gene:ENSPMAG00000003892.1 transcript:ENSPMAT00000004302.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 199.519 bits (506), Expect = 9.142e-59 Identity = 107/196 (54.59%), Postives = 137/196 (69.90%), Query Frame = 3
Query: 588 GVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQH-ADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFG 1172
G++ ++ N + +RNSV+L IRK+ +AP+KP PQP AE + F+MS L LEASLDK YYHGE I+VNV V NNS KT+KKIK+ V++ ADICL+N YKC V E+G + CKVY + PLL++NRDKRGLALDGKLKHEDTNLASSTI+ + NKE LGI+V Y+VKV+L++ G
Sbjct: 1 GIEQVNRSSAPANTVHHSRRRNSVRLVIRKVQFAPEKPGPQPMAETTRQFLMSDKPLHLEASLDKMIYYHGEPINVNVHVTNNSTKTVKKIKMTVKEFFADICLFNTAQYKCPVAT---EEGDDTVGPSSTLCKVYTLTPLLASNRDKRGLALDGKLKHEDTNLASSTIVQDGANKEVLGILVSYRVKVKLIVSRG 193
BLAST of slc6a-8 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001684.1 (pep scaffold:Pmarinus_7.0:GL482707:4904:15978:1 gene:ENSPMAG00000001516.1 transcript:ENSPMAT00000001684.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 199.134 bits (505), Expect = 9.984e-58 Identity = 112/259 (43.24%), Postives = 163/259 (62.93%), Query Frame = 2
Query: 2009 SDPQTRKHWASQLDFLFSIIGFAVDFSNVFRFPYICFQNGGGAFLIPYFVTLLLCALPMFYIELLFGQYMRCGGLTIWKICPLFKGVGYASVLLNFYVALYYNVIIAWSLYYLFVSFSPTLPWTVCDKWWNS-ENCYFISNYLSLLEKNNNTNMFTDSATEYLEN-NVLMVNQSSGIGNLGPLKWNMAXXXXXXXXXXXXXXFKGVKFLGKAVWVTAILPYVVLAALLIRGVMLEGAVEGIKYFI--TPNFKMLLKPDV 2773
+ R +WAS+ +++ S+IG AV N++RFPY+ ++NGGGAFLIPY + L LP+F++E GQ+ G +TIWK+ PL KG+G+ V+ + +ALYYN IIA+ L+YLF SF+ LPW+ C KWW + ENC+ S S L + N +++ + T + N + +S + G + W++AL+LLL +I+ L KG+K GK V+ TAI PYVVL LLIRG L GA+ GI+Y+I NF L +V
Sbjct: 1 DENAERGNWASKSEYMLSMIGNAVGLGNLWRFPYLAYKNGGGAFLIPYIIMLAFVGLPLFFLECSIGQFASLGPITIWKVVPLLKGLGWMMVITSSLIALYYNSIIAYGLFYLFASFTSELPWSSCKKWWGADENCFDRSVCNSSLAEGNCSSVNSSKQTPSEQYWNKYALRRSESMDETGDVVWHLALTLLLSWIVTCAALVKGIKSSGKVVYFTAIFPYVVLIILLIRGATLPGAILGIEYYIGRQSNFTKLQSAEV 259
BLAST of slc6a-8 vs. Ensembl Nematostella
Match: EDO43535 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RYJ9]) HSP 1 Score: 400.979 bits (1029), Expect = 1.537e-129 Identity = 204/302 (67.55%), Postives = 243/302 (80.46%), Query Frame = 3
Query: 189 KITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKD-RKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTI 1091
+IT YLGKRDFID++ ++DP+DGVVL+DP+Y+KD +KVF HVLAAFRYGREDLDVLGLTFRKDL+LA+ QVYPP KT D + LTRLQERL+KKLG NAYPF FELP +P+SVTLQP P D GKPCGVDYELKTYVA++ +EK HKR++V+LAIRKLTYA ++P PQP +E KDF+MS L +EASLDK YYHGE+I+VNV++ N S++ KKIKI VRQ ADICL++ YKC V LE EDGFP++ S T KVY + PLL NRDKRGLALDGKLKHEDTNLASST+
Sbjct: 13 QITTYLGKRDFIDHVKHIDPIDGVVLVDPEYVKDGKKVFAHVLAAFRYGREDLDVLGLTFRKDLFLATVQVYPP-------KTDD--QKALTRLQERLLKKLGSNAYPFKFELPPGSPSSVTLQPAPGDTGKPCGVDYELKTYVAESLEEKPHKRDTVRLAIRKLTYATEQPQPQPFSEGEKDFMMSQHPLHVEASLDKGLYYHGETIAVNVIISNRSSRNCKKIKITVRQFADICLFSTAQYKCPVASLESEDGFPVHPSGT-LTKVYCLTPLLGENRDKRGLALDGKLKHEDTNLASSTM 304
BLAST of slc6a-8 vs. Ensembl Nematostella
Match: EDO31545 (Transporter [Source:UniProtKB/TrEMBL;Acc:A7SXK0]) HSP 1 Score: 329.717 bits (844), Expect = 3.294e-107 Identity = 176/394 (44.67%), Postives = 249/394 (63.20%), Query Frame = 2
Query: 2024 RKHWASQLDFLFSIIGFAVDFSNVFRFPYICFQNGGGAFLIPYFVTLLLCALPMFYIELLFGQYMRCGGLTIW-KICPLFKGVGYASVLLNFYVALYYNVIIAWSLYYLFVSFSPTLPWTVCDKWWNSENCYF----ISNYLSLLEKNNN-----------------TNMFTDS---------ATEYLENNVLMVNQSSGIGNLGPLKWNMAXXXXXXXXXXXXXXFKGVKFLGKAVWVTAILPYVVLAALLIRGVMLEGAVEGIKYFITPNFKMLLKPDVWIAAATQIFFSVGVGFSVHIAYASYNNFHTPVHNNCLIAAAVNSLTSLFSGFVIFAYLGYMSHQMRKPLEKVVNGNLTLIFIVYPLALSTLPGGNFWAVIFFLMLFNLGLDSS 3112
R+ W + DFL S IGFAV NV+RFPY+C+ NGGGAFL+PY + L+LC +PMF++EL GQY G + +W ICPLF+G+G+AS++++F V +YYNVIIAW LY+L VSF + W CD WWN++NCY S SL +NN TN T+ + E+ EN +L + S GIG G ++W + + L+L ++ +Y C++KGVK GK V+ TA PY+VL L +RGV L GA +GI +++ P + L P VW+AAATQIF+S+G+GF +A SYN FH + + + + +N TS+F+GFVIF+ LG+MSH + KP+E+V N L F+VYP A++ +P WA++FF M+ LGLDS
Sbjct: 6 RETWGKKADFLLSCIGFAVGLGNVWRFPYLCYANGGGAFLLPYLIMLVLCGMPMFFMELSAGQYFSLGPIGVWGAICPLFRGIGFASIVISFLVCVYYNVIIAWCLYFLAVSFRSEVLWKHCDNWWNTDNCYAGRIPESMSCSLGSGSNNSLVNSTLANATVLAANATNATTECLFPENQVSPSLEFWENYILRL--SDGIGEAGEIRWQILVCLILAWVGVYFCMWKGVKSSGKVVYFTATFPYLVLFILFVRGVTLPGADKGIAFYLKPEWHRLKDPKVWVAAATQIFYSLGIGFGSLVAMGSYNKFHNNIFKDAISISLINCGTSVFAGFVIFSTLGFMSHVLNKPIEEVANSGPGLAFVVYPEAIAQMPISPLWAILFFFMILTLGLDSQ 397 HSP 2 Score: 79.7221 bits (195), Expect = 3.294e-107 Identity = 47/142 (33.10%), Postives = 72/142 (50.70%), Query Frame = 1
Query: 3154 QFGALEALLTGILDEFDFVFKKMKYKREITTAVMLTILYFLSLPNTTYGGFFLIQLYDKYSAGPSLLAVSLLECIGFIWIYGIDNTADIIKQMNGFDLHIIFRILFKYITPFAILAITIAQLFTDEIFTVNLGTRTYTYPQW 3579
QFG +EA++TGI+DE+ K+ +E+ AV + + L + N T GG +++ L+D S G SLL + E + WIYG D + I+ M G +R +K+ P + I F IF + +Y YPQW
Sbjct: 397 QFGMMEAVITGIIDEYPVCRKR----KELFIAVACFLCFLLGITNVTQGGAYVLNLFDYQSGGVSLLFLGFFETVCLAWIYGADRFSKDIEDMVGSRPAAWWRFTWKFCAPTVMAGI----FFYSIIFWQGVSYGSYKYPQW 530
BLAST of slc6a-8 vs. Ensembl Nematostella
Match: EDO39707 (Transporter [Source:UniProtKB/TrEMBL;Acc:A7S977]) HSP 1 Score: 315.849 bits (808), Expect = 3.855e-105 Identity = 161/388 (41.49%), Postives = 246/388 (63.40%), Query Frame = 2
Query: 1970 AENSDESKNLENHSDPQTRKHWASQLDFLFSIIGFAVDFSNVFRFPYICFQNGGGAFLIPYFVTLLLCALPMFYIELLFGQYMRCGGLTIWK-ICPLFKGVGYASVLLNFYVALYYNVIIAWSLYYLFVSFSPTLPWTVCDKWWNSENCY------FISNYLSLLEKNNNTNMFTDSATEYLENNVLMVNQSSGIGNLGPLKWNMAXXXXXXXXXXXXXXFKGVKFLGKAVWVTAILPYVVLAALLIRGVMLEGAVEGIKYFITPNFKMLLKPDVWIAAATQIFFSVGVGFSVHIAYASYNNFHTPVHNNCLIAAAVNSLTSLFSGFVIFAYLGYMSHQMRKPLEKVVNGNLTLIFIVYPLALSTLPGGNFWAVIFFLMLFNLGLDSS 3112
+S++S ++ + QTR W+S+ +F+ S +G+ V F NV+RFPY+C++NGG FLIPYF+ L++ +P+F++EL GQ+ G + +WK ICPL KG+GYA ++++ +YY VI+AW+ YYLF+SF +PW CD WN++ C + N L N T T + E+ NNVL + + I + G ++W + + +L +I++Y CLFKG+K GK V+ TA P++VL L+IRG LEG+++G+ Y++ P+++ L P VWI AATQI++S+GVGF I + SYN F+ VH + L+ + N TS F+GFV+F+ LG+M+ + + KV L F+ YP A+S +P WAV+FF ML LGLDS
Sbjct: 22 TSSSEDSPQIDVEEE-QTRDKWSSKAEFMLSSLGYCVGFGNVWRFPYLCYKNGGATFLIPYFIMLIVNGIPLFFLELAIGQWFSSGVIGVWKSICPLLKGIGYAICMISYLCCIYYIVILAWTFYYLFMSFQAVVPWKTCDNPWNTKFCRAKRSGDLLLNCTELDLPQNCTAKPTSPSGEFWSNNVLEMTED--ISDFGDMRWPLFGTFILSWIVVYFCLFKGIKSSGKVVYFTATFPFIVLFILMIRGATLEGSLDGVIYYLNPDWERLADPQVWIYAATQIYWSLGVGFGALITFGSYNKFNNNVHKDALVISIANCSTSFFAGFVVFSVLGFMALTLDTTVAKVATSGPGLAFVAYPEAISQMPVSTLWAVLFFFMLITLGLDSQ 406 HSP 2 Score: 86.2705 bits (212), Expect = 3.855e-105 Identity = 66/187 (35.29%), Postives = 105/187 (56.15%), Query Frame = 1
Query: 3154 QFGALEALLTGILDEFDFVFKKMKYKREITTAVMLTILYFLSLPNTTYGGFFLIQLYDKYSAGPSLLAVSLLECIGFIWIYGIDNTADIIKQMNGFDLHIIFRILFKYITPFAILAITIAQLFTDEIFTVNLGTRTYTYPQWXXXXXXXXXXXXXXXXXXFGGVVLYRIKATSWKERICLSISPNWE 3714
QF +EA++T I+DE+ +V + K+++ + ++ L L LP GG ++ L D AG SLL V+LLE I WIYG+D +D ++ M G FRI +KY++P LAI +A L + N YP W+ +IG ++ LSS++MIP F +Y+ ++ + +ERI + P+ E
Sbjct: 406 QFATIEAVITAIVDEYPWV-RGTKWRKPVFVLILCISLCILGLPCVFQGGMWIFNLMDYQVAGLSLLIVALLEIITIGWIYGVDRFSDDVEYMTGRRPMRWFRICWKYVSPLCTLAIILANLIQWKGVKYN----GKPYPGWAELIGWMLMLSSVLMIPAFAIHEIYK-RSGTLRERITFLLKPDEE 586
BLAST of slc6a-8 vs. Ensembl Nematostella
Match: EDO32356 (Transporter [Source:UniProtKB/TrEMBL;Acc:A7SVA2]) HSP 1 Score: 313.538 bits (802), Expect = 1.010e-102 Identity = 156/365 (42.74%), Postives = 232/365 (63.56%), Query Frame = 2
Query: 2024 RKHWASQLDFLFSIIGFAVDFSNVFRFPYICFQNGGGAFLIPYFVTLLLCALPMFYIELLFGQYMRCGGLTIWKICPLFKGVGYASVLLNFYVALYYNVIIAWSLYYLFVSFSPTLPWTVCDKWWNSENCYFISNYLSLLEKNNNTNMFTDSATEYLENNVL--MVNQSSGIGNLGPLKWNMAXXXXXXXXXXXXXXFKGVKFLGKAVWVTAILPYVVLAALLIRGVMLEGAVEGIKYFITPNFKMLLKPDVWIAAATQIFFSVGVGFSVHIAYASYNNFHTPVHNNCLIAAAVNSLTSLFSGFVIFAYLGYMSHQMRKPLEKVVNGNLTLIFIVYPLALSTLPGGNFWAVIFFLMLFNLGLDSS 3112
R+ W +LDF+ ++IGF+V N++RFPY+C++NGGG FLIPY + LLL +P+ +E+ GQ+M GG+T WKICPLF+G+GYASV++ Y+ +YY VI+ W+ YY+F SF LPW+ CD WN+E C+ ++ + + + L + ++N S G+ +G + W MAL LL +I+ YLC+FKGVK G+ V+ TA PYV+L + +R V L GA EGI++++ P++ L VW+ AATQ+FFS +G IA SYN F + +C+I A VNS TS + GFVIF+ LG+M+ + P+++V L FI YP A++ +P W+++FF M+ LGLDS
Sbjct: 9 RETWVGKLDFILALIGFSVGLGNIWRFPYLCYKNGGGCFLIPYLICLLLAGVPLLILEVCLGQFMSQGGITAWKICPLFQGIGYASVVIVQYLNIYYIVILGWAFYYMFHSFQAVLPWSHCDNDWNTEKCHVGRKMITTFNSGSKCCQLFIKSFKCLWKDAADYVLNISGGLDQIGTINWQMALCLLFAWIVCYLCVFKGVKSTGRVVYFTATFPYVLLTIICVRAVTLPGAREGIRFYLEPDWSRLQDGSVWLQAATQVFFSYSIGLGTLIALGSYNKFKNNCYRDCIIFACVNSGTSFYGGFVIFSVLGFMAEKQGVPIQEVAESGPGLAFIAYPAAVAEMPISPLWSILFFFMVILLGLDSE 373 HSP 2 Score: 80.8777 bits (198), Expect = 1.010e-102 Identity = 51/143 (35.66%), Postives = 75/143 (52.45%), Query Frame = 1
Query: 3154 QFGALEALLTGILDEFDFVFKKMKYKREITTAVMLTILYFLSLPNTTYGGFFLIQLYDKYSA-GPSLLAVSLLECIGFIWIYGIDNTADIIKQMNGFDLHIIFRILFKYITPFAILAITIAQLFTDEIFTVNLGTRTYTYPQW 3579
+F +E +T I+D F ++ Y++EI A T +F+ L T GG ++ QL+D YSA G LL +SL E IG W+YG + + M GF ++ ++ + + TP LA+ I L E T NL TY YP W
Sbjct: 373 EFVGVEGFVTAIVDMFPGYLRR-GYRKEIFIAACSTFWFFIGLVMVTEGGMYVFQLFDNYSASGICLLWISLFESIGIGWVYGAERFYQNMTDMIGFRINPYLKVCWIFCTPIFCLAVFIFSLVNYEPLTYNL---TYKYPVW 511
BLAST of slc6a-8 vs. Ensembl Nematostella
Match: EDO40151 (Transporter [Source:UniProtKB/TrEMBL;Acc:A7S7X6]) HSP 1 Score: 320.472 bits (820), Expect = 1.649e-101 Identity = 172/385 (44.68%), Postives = 253/385 (65.71%), Query Frame = 2
Query: 1976 NSDESKNLENHSDP-----QTRKHWASQLDFLFSIIGFAVDFSNVFRFPYICFQNGGGAFLIPYFVTLLLCALPMFYIELLFGQYMRCGGLTIW-KICPLFKGVGYASVLLNFYVALYYNVIIAWSLYYLFVSFSPTLPWTVCDKWWNSENCYFISNYLSLLEKNNNTNMFTDSATEYLENNVLMVNQSSGIGNLGPLKWNMAXXXXXXXXXXXXXXFKGVKFLGKAVWVTAILPYVVLAALLIRGVMLEGAVEGIKYFITPNFKMLLKPDVWIAAATQIFFSVGVGFSVHIAYASYNNFHTPVHNNCLIAAAVNSLTSLFSGFVIFAYLGYMSHQMRKPLEKVVNGNLTLIFIVYPLALSTLPGGNFWAVIFFLMLFNLGLDSS 3112
+D +K L+N ++R+ W +++FLF+ IGFAV + N +RFPY+CF+NGGGAFLIPY + L L +P+F++EL GQ ++ G + W KICPLF G+G+AS++++F V++YYNVI+AWSLY+L+ SF +PW C WN+ +CY + + N + S+ E+L NVL + +S I G L ++ L LL+ +I++Y +++G++ GK V+VTA LPY++L I+GV L GA++G+ YFITP + L P VWI AA+QI +S+ +GF V I +ASYN V ++ L+ + +N TS+F+GFVIFA +GYM+H K + +V + L+FIVYP A+S LP WAVIFFLML LGLDS
Sbjct: 2 TADSNKPLKNDEKKDLVTVESRERWDRKIEFLFACIGFAVGYGNFWRFPYMCFKNGGGAFLIPYVLFLCLGGIPLFFMELSLGQLLQEGPIKAWQKICPLFSGIGFASIVISFIVSIYYNVILAWSLYFLYNSFFADIPWVGCHHSWNTPDCY-------VYNASANASG-VSSSREFLVKNVLEITKS--IEEPGGLSVHLTLCLLVAWILVYFSIWRGIRTTGKVVYVTATLPYIILVIFFIKGVTLPGAIDGVLYFITPQWDRLQDPKVWIDAASQILYSLTIGFGVLIGFASYNPRKNNVFSDALLISVINCATSVFAGFVIFAIVGYMAHVQEKSVPEVASQGPGLVFIVYPAAISQLPFPQIWAVIFFLMLIALGLDSQ 376 HSP 2 Score: 69.707 bits (169), Expect = 1.649e-101 Identity = 43/142 (30.28%), Postives = 70/142 (49.30%), Query Frame = 1
Query: 3154 QFGALEALLTGILDEFDFVFKKMKYKREITTAVMLTILYFLSLPNTTYGGFFLIQLYDKYSAGPSLLAVSLLECIGFIWIYGIDNTADIIKQMNGFDLHIIFRILFKYITPFAILAITIAQLFTDEIFTVNLGTRTYTYPQW 3579
QFG +E + +++++ +++ RE+ V+ +++ L L + GG F+ L+D +S G SLL V E + WIYG AD I QM G + + I +KYI+P +L I + L + T YP W
Sbjct: 376 QFGQVEVVAAALIEQWP---RQLHKHRELVVLVICFVMFLLGLSCVSKGGMFVFNLFDSFSCGLSLLFVVCFELLVIGWIYGARRYADNISQMIGRPVLQWWVICWKYISPIMVLGIFVFSLAKYKRIT----YENVPYPAW 510
BLAST of slc6a-8 vs. Ensembl Medaka
Match: arrb2a (arrestin beta 2 [Source:NCBI gene;Acc:101159286]) HSP 1 Score: 469.544 bits (1207), Expect = 1.595e-153 Identity = 249/454 (54.85%), Postives = 316/454 (69.60%), Query Frame = 3
Query: 144 EKETSKVFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFGTSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRLTGG 1505
+K ++VFKKSSPN K+T YLGKRDF+D+LD+VDPVDGV+L+DP+YLKDRKVFV + AFRYGREDLDVLGL+FRKDLY+++ Q +PP+ + ++ P+ +RLQ+RL+KKLG +A+PFYF +P N P SVTLQPGP D GK CGVD+E++ + A + +EK HKRNSV+L IRK+ YAP+KP PQP E + F+MS SL LEASLDKE YYHGE ISVNV V NNS KT+K++KI+VRQ+ADICL++ YKC V +LE +D SS + +CKVY + P L NR+KRGLALDGKLKHEDTNLASSTI+ + TNKE LGI+V Y+VKV+LV+ G D+S+ELPF L HPKP EP +S P + E D ID +LI+ +T+ +S DDD +FEDFARLRL G
Sbjct: 3 DKAGTRVFKKSSPNCKLTVYLGKRDFVDHLDHVDPVDGVILVDPEYLKDRKVFVTLTCAFRYGREDLDVLGLSFRKDLYISTFQAFPPVPE---ERKPN------SRLQDRLLKKLGQHAHPFYFTIPQNLPCSVTLQPGPEDTGKACGVDFEIRAFCAKSIEEKIHKRNSVRLVIRKVQYAPEKPGPQPMVETTRSFLMSDRSLHLEASLDKELYYHGEPISVNVHVTNNSTKTVKRVKISVRQYADICLFSTAQYKCPVAQLEADDQV---SSSSTFCKVYTLTPTLDKNREKRGLALDGKLKHEDTNLASSTIVKDVTNKEVLGILVSYRVKVKLVVSRG-GDVSVELPFILMHPKPV--EPPLSR------------------------------PQSAVPEMDPP-IDTNLIEFETN------------VSQDDDFVFEDFARLRLKGA 398
BLAST of slc6a-8 vs. Ensembl Medaka
Match: arrb1 (arrestin beta 1 [Source:NCBI gene;Acc:101163309]) HSP 1 Score: 466.848 bits (1200), Expect = 7.410e-152 Identity = 231/369 (62.60%), Postives = 285/369 (77.24%), Query Frame = 3
Query: 159 KVFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFGT-----------SDISLELPFTLSHPKPADE 1232
+VFKK+SPNGK+T YLGKRDF+D++D+VDPVDGV+LIDP+YLK+RKVFV + AFRYGREDLDVLGLTFRKDL+LA+ Q +PPL + + LTRLQERLIKKLG +AYPF FE+P N P SVTLQPGP D GK CGVD+E+K + A+N +EK HKRNSV+L IRK+ YAP+KP PQP+AE + F+MS L LEASLDKE YYHGE ISVNV V NN+NKT+K++KI+VRQHADICL+N YKC V E +D + + + +CKV+ + P L+NN++KRGLALDGKLKHEDTNLASST++ + NKE LGI+V YKVKV+LV+ G SD+S+ELPFTL HPKP +E
Sbjct: 7 RVFKKASPNGKLTVYLGKRDFVDHVDFVDPVDGVILIDPEYLKERKVFVTLTCAFRYGREDLDVLGLTFRKDLFLANIQAFPPLPE---------EKKSLTRLQERLIKKLGEHAYPFIFEIPLNLPCSVTLQPGPEDTGKACGVDFEVKAFCAENAEEKIHKRNSVRLVIRKVQYAPEKPGPQPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKRMKISVRQHADICLFNTAQYKCPVAVEESDD---VVAPSSTFCKVFTLTPFLANNQEKRGLALDGKLKHEDTNLASSTLLRDGANKEILGILVSYKVKVKLVVSRGGSPVMHLNLLCFSDVSVELPFTLMHPKPLEE 363
BLAST of slc6a-8 vs. Ensembl Medaka
Match: arrb2a (arrestin beta 2 [Source:NCBI gene;Acc:101159286]) HSP 1 Score: 463.766 bits (1192), Expect = 2.646e-151 Identity = 247/450 (54.89%), Postives = 314/450 (69.78%), Query Frame = 3
Query: 156 SKVFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFGTSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRLTGG 1505
S+VFKKSSPN K+T YLGKRDF+D+LD+VDPVDGV+L+DP+YLKDRKVFV + AFRYGREDLDVLGL+FRKDLY+++ Q +PP+ + ++ P+ +RLQ+RL+KKLG +A+PFYF +P N P SVTLQPGP D GK CGVD+E++ + A + +EK HKRNSV+L IRK+ YAP+KP PQP E + F+MS SL LEASLDKE YYHGE ISVNV V NNS KT+K++KI+VRQ+ADICL++ YKC V +LE +D SS + +CKVY + P L NR+KRGLALDGKLKHEDTNLASSTI+ + TNKE LGI+V Y+VKV+LV+ G D+S+ELPF L HPKP EP +S P+ T S + +L+ ++T +H +S DDD +FEDFARLRL G
Sbjct: 7 SRVFKKSSPNCKLTVYLGKRDFVDHLDHVDPVDGVILVDPEYLKDRKVFVTLTCAFRYGREDLDVLGLSFRKDLYISTFQAFPPVPE---ERKPN------SRLQDRLLKKLGQHAHPFYFTIPQNLPCSVTLQPGPEDTGKACGVDFEIRAFCAKSIEEKIHKRNSVRLVIRKVQYAPEKPGPQPMVETTRSFLMSDRSLHLEASLDKELYYHGEPISVNVHVTNNSTKTVKRVKISVRQYADICLFSTAQYKCPVAQLEADDQV---SSSSTFCKVYTLTPTLDKNREKRGLALDGKLKHEDTNLASSTIVKDVTNKEVLGILVSYRVKVKLVVSRG-GDVSVELPFILMHPKPV--EPPLSR---------------PQSGRSTRRRHYSGL---------------ELVSMET-----DH------VSQDDDFVFEDFARLRLKGA 400
BLAST of slc6a-8 vs. Ensembl Medaka
Match: slc6a2 (solute carrier family 6 member 2 [Source:NCBI gene;Acc:101172721]) HSP 1 Score: 358.221 bits (918), Expect = 1.358e-119 Identity = 198/420 (47.14%), Postives = 272/420 (64.76%), Query Frame = 2
Query: 1871 KMQNIELNESKLI--KSHXXXXXXXXXXCRTIALLAENSDESKNLENHSDPQTRKHWASQLDFLFSIIGFAVDFSNVFRFPYICFQNGGGAFLIPYFVTLLLCALPMFYIELLFGQYMRCGGLTIWKICPLFKGVGYASVLLNFYVALYYNVIIAWSLYYLFVSFSPTLPWTVCDKWWNSENCYFISNY-LSLLEKNNN--TNMFTDSATEYLENNVLMVNQSSGIGNLGPLKWNMAXXXXXXXXXXXXXXFKGVKFLGKAVWVTAILPYVVLAALLIRGVMLEGAVEGIKYFITPNFKMLLKPDVWIAAATQIFFSVGVGFSVHIAYASYNNFHTPVHNNCLIAAAVNSLTSLFSGFVIFAYLGYMSHQMRKPLEKVVNGNLTLIFIVYPLALSTLPGGNFWAVIFFLMLFNLGLDSSV 3115
K N+E E +LI K N + N + T A A S ++E R+ W ++DFL S+IGFAVD +NV+RFPY+C++NGGGAFLIPY + L++ +P+FY+EL GQY R G T+WKICP+FKGVGYA +++ YV YYNVIIAWSLYYL+ S + LPW C WNS NC + S +KN + N FT A+EY E VL +++S GI +LG + + L L+++ I+Y L+KGVK GK V++TA +PYVVL LLIRG+ L GA+ GIK ++ + L VWI AATQIF+S+G GF V IA++SYN F + + ++ +AVN +TS SGF IF+ LGYM+ + ++ V L+FI+YP A+STLPG FWA++FF+ML LG+DSS+
Sbjct: 18 KQCNVEKKEVELILVKDQNGVQYTNSTIIPTAARCAGPHGTSTDIE-------RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLIPYILFLVIAGMPLFYMELALGQYNREGAATVWKICPVFKGVGYAVIVIALYVGFYYNVIIAWSLYYLYSSMTAELPWLKCGHSWNSINCTDPQHINASFFDKNTSYANNKFT-PASEYYERGVLHLHESKGIEDLGLPRLELTLCLVVVVFILYFSLWKGVKSSGKVVYITATMPYVVLFVLLIRGITLPGALNGIKAYLNFSLSELNNLQVWIDAATQIFYSLGAGFGVLIAFSSYNKFDNNCYRDAILTSAVNCITSFVSGFAIFSVLGYMAQKYNMDIKAVATDGPGLVFIIYPEAISTLPGSTFWAIVFFIMLLTLGIDSSM 429 HSP 2 Score: 93.9745 bits (232), Expect = 1.358e-119 Identity = 61/208 (29.33%), Postives = 114/208 (54.81%), Query Frame = 1
Query: 3154 QFGALEALLTGILDEFDFVFKKMKYKREITTAVMLTILYFLSLPNTTYGGFFLIQLYDKYSAGPSLLAVSLLECIGFIWIYGIDNTADIIKQMNGFDLHIIFRILFKYITPFAILAITIAQLFTDEIFTVNLGTRTYTYPQWXXXXXXXXXXXXXXXXXXFGGVVLYRIKATSWKERICLSISPNWEHRDIRSKTQFNRLKINHWITV 3777
G +EA++TG+ D+F F +K R++ T + ++L T GG +++ L DKY+AG S+L L+E IG W YG+D ++ I+QM GF + +R+ +K+++P +L + IA T L Y +P + ++G +++SS++ +P + + ++ T + ERI I+P EH + ++ + K+ HW+ +
Sbjct: 428 SMGGMEAVITGLSDDFKF----LKRNRKLFTFATAFGTFLMALICVTNGGIYVLTLLDKYAAGTSILFAVLIEAIGVSWFYGVDRFSEDIEQMMGFKPGLYWRLCWKFVSPVFLLFVVIASTVTSS----GLKYGDYVFPNGANLLGWGVAMSSMLFVPFYAIYKFFSVRGT-FTERIAYCITPEHEHHKV-AEGNVRQFKLKHWLAI 625
BLAST of slc6a-8 vs. Ensembl Medaka
Match: slc6a2 (solute carrier family 6 member 2 [Source:NCBI gene;Acc:101172721]) HSP 1 Score: 358.221 bits (918), Expect = 1.358e-119 Identity = 198/420 (47.14%), Postives = 272/420 (64.76%), Query Frame = 2
Query: 1871 KMQNIELNESKLI--KSHXXXXXXXXXXCRTIALLAENSDESKNLENHSDPQTRKHWASQLDFLFSIIGFAVDFSNVFRFPYICFQNGGGAFLIPYFVTLLLCALPMFYIELLFGQYMRCGGLTIWKICPLFKGVGYASVLLNFYVALYYNVIIAWSLYYLFVSFSPTLPWTVCDKWWNSENCYFISNY-LSLLEKNNN--TNMFTDSATEYLENNVLMVNQSSGIGNLGPLKWNMAXXXXXXXXXXXXXXFKGVKFLGKAVWVTAILPYVVLAALLIRGVMLEGAVEGIKYFITPNFKMLLKPDVWIAAATQIFFSVGVGFSVHIAYASYNNFHTPVHNNCLIAAAVNSLTSLFSGFVIFAYLGYMSHQMRKPLEKVVNGNLTLIFIVYPLALSTLPGGNFWAVIFFLMLFNLGLDSSV 3115
K N+E E +LI K N + N + T A A S ++E R+ W ++DFL S+IGFAVD +NV+RFPY+C++NGGGAFLIPY + L++ +P+FY+EL GQY R G T+WKICP+FKGVGYA +++ YV YYNVIIAWSLYYL+ S + LPW C WNS NC + S +KN + N FT A+EY E VL +++S GI +LG + + L L+++ I+Y L+KGVK GK V++TA +PYVVL LLIRG+ L GA+ GIK ++ + L VWI AATQIF+S+G GF V IA++SYN F + + ++ +AVN +TS SGF IF+ LGYM+ + ++ V L+FI+YP A+STLPG FWA++FF+ML LG+DSS+
Sbjct: 18 KQCNVEKKEVELILVKDQNGVQYTNSTIIPTAARCAGPHGTSTDIE-------RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLIPYILFLVIAGMPLFYMELALGQYNREGAATVWKICPVFKGVGYAVIVIALYVGFYYNVIIAWSLYYLYSSMTAELPWLKCGHSWNSINCTDPQHINASFFDKNTSYANNKFT-PASEYYERGVLHLHESKGIEDLGLPRLELTLCLVVVVFILYFSLWKGVKSSGKVVYITATMPYVVLFVLLIRGITLPGALNGIKAYLNFSLSELNNLQVWIDAATQIFYSLGAGFGVLIAFSSYNKFDNNCYRDAILTSAVNCITSFVSGFAIFSVLGYMAQKYNMDIKAVATDGPGLVFIIYPEAISTLPGSTFWAIVFFIMLLTLGIDSSM 429 HSP 2 Score: 93.9745 bits (232), Expect = 1.358e-119 Identity = 61/208 (29.33%), Postives = 114/208 (54.81%), Query Frame = 1
Query: 3154 QFGALEALLTGILDEFDFVFKKMKYKREITTAVMLTILYFLSLPNTTYGGFFLIQLYDKYSAGPSLLAVSLLECIGFIWIYGIDNTADIIKQMNGFDLHIIFRILFKYITPFAILAITIAQLFTDEIFTVNLGTRTYTYPQWXXXXXXXXXXXXXXXXXXFGGVVLYRIKATSWKERICLSISPNWEHRDIRSKTQFNRLKINHWITV 3777
G +EA++TG+ D+F F +K R++ T + ++L T GG +++ L DKY+AG S+L L+E IG W YG+D ++ I+QM GF + +R+ +K+++P +L + IA T L Y +P + ++G +++SS++ +P + + ++ T + ERI I+P EH + ++ + K+ HW+ +
Sbjct: 428 SMGGMEAVITGLSDDFKF----LKRNRKLFTFATAFGTFLMALICVTNGGIYVLTLLDKYAAGTSILFAVLIEAIGVSWFYGVDRFSEDIEQMMGFKPGLYWRLCWKFVSPVFLLFVVIASTVTSS----GLKYGDYVFPNGANLLGWGVAMSSMLFVPFYAIYKFFSVRGT-FTERIAYCITPEHEHHKV-AEGNVRQFKLKHWLAI 625
BLAST of slc6a-8 vs. Planmine SMEST
Match: SMESG000037193.1 (SMESG000037193.1) HSP 1 Score: 961.829 bits (2485), Expect = 0.000e+0 Identity = 478/478 (100.00%), Postives = 478/478 (100.00%), Query Frame = 3
Query: 87 MSNNHDVDLDDIKKQGTSKEKETSKVFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFGTSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRLTGGDKNDP 1520
MSNNHDVDLDDIKKQGTSKEKETSKVFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTIKKIKIAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFGTSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRLTGGDKNDP
Sbjct: 1 MSNNHDVDLDDIKKQGTSKEKETSKVFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTIKKIKIAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFGTSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRLTGGDKNDP 478
BLAST of slc6a-8 vs. Planmine SMEST
Match: SMESG000006894.1 (SMESG000006894.1) HSP 1 Score: 512.686 bits (1319), Expect = 6.271e-170 Identity = 268/470 (57.02%), Postives = 328/470 (69.79%), Query Frame = 3
Query: 105 VDLDDIKKQGTSKEKETSKVFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFGTSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRLTGGDKN 1514
+D+D +GT K K ++VFKKSSPN KIT YLGKRDF+D VDP++G+VL+D DY+KD+KVF+HVLA FRYGR+DLDVLGLTFRKDL+L++QQ+YPP N + P LT+LQERLI KLGHNA PF F++PH TPASVTLQP P DNGKPCGVDYELK Y++D PD K HKRNSV+L IRKLT+A P PQ E+ KDF M G +RLE SLDKEKYYHGESI+VNV VDN SNK I+KI++ V Q ADI L+ YKC+VDE+E +DGFPI Q GWCK++ +CPLLSNNRDKRGLALDG L++EDTNLASST++NEN++ EN+GIIV+Y ++VRL+LGFGTSDI LE+PF L+HP P +D ++V ND L DS ID D +L +++ IFEDFARLRL G + N
Sbjct: 2 IDMD----EGTEK-KLGTRVFKKSSPNNKITIYLGKRDFLDKNGLVDPIEGIVLLDSDYVKDKKVFIHVLALFRYGRDDLDVLGLTFRKDLFLSTQQIYPPTNSI----IP-----SLTKLQERLIGKLGHNAIPFIFQIPHMTPASVTLQPDPEDNGKPCGVDYELKVYMSDGPDGKTHKRNSVRLLIRKLTFATSDPGPQQFQEVTKDFKMCGGKIRLETSLDKEKYYHGESIAVNVTVDNTSNKIIRKIRLHVVQLADIMLFTRAMYKCVVDEMEIDDGFPISPGQIGWCKIFHMCPLLSNNRDKRGLALDGLLRYEDTNLASSTVLNENSDLENMGIIVKYFIRVRLILGFGTSDIQLEIPFILTHPNP-----------------------------DSDFRIPNSVSND-LNPLDSNGIDTDFNKLQ--------------FKQEEEFIFEDFARLRLYGNETN 413
BLAST of slc6a-8 vs. Planmine SMEST
Match: SMESG000006894.1 (SMESG000006894.1) HSP 1 Score: 512.686 bits (1319), Expect = 6.611e-170 Identity = 266/462 (57.58%), Postives = 324/462 (70.13%), Query Frame = 3
Query: 129 QGTSKEKETSKVFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNKVEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFGTSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRLTGGDKN 1514
+GT K K ++VFKKSSPN KIT YLGKRDF+D VDP++G+VL+D DY+KD+KVF+HVLA FRYGR+DLDVLGLTFRKDL+L++QQ+YPP N + P LT+LQERLI KLGHNA PF F++PH TPASVTLQP P DNGKPCGVDYELK Y++D PD K HKRNSV+L IRKLT+A P PQ E+ KDF M G +RLE SLDKEKYYHGESI+VNV VDN SNK I+KI++ V Q ADI L+ YKC+VDE+E +DGFPI Q GWCK++ +CPLLSNNRDKRGLALDG L++EDTNLASST++NEN++ EN+GIIV+Y ++VRL+LGFGTSDI LE+PF L+HP P +D ++V ND L DS ID D +L +++ IFEDFARLRL G + N
Sbjct: 3 EGTEK-KLGTRVFKKSSPNNKITIYLGKRDFLDKNGLVDPIEGIVLLDSDYVKDKKVFIHVLALFRYGRDDLDVLGLTFRKDLFLSTQQIYPPTNSI----IP-----SLTKLQERLIGKLGHNAIPFIFQIPHMTPASVTLQPDPEDNGKPCGVDYELKVYMSDGPDGKTHKRNSVRLLIRKLTFATSDPGPQQFQEVTKDFKMCGGKIRLETSLDKEKYYHGESIAVNVTVDNTSNKIIRKIRLHVVQLADIMLFTRAMYKCVVDEMEIDDGFPISPGQIGWCKIFHMCPLLSNNRDKRGLALDGLLRYEDTNLASSTVLNENSDLENMGIIVKYFIRVRLILGFGTSDIQLEIPFILTHPNP-----------------------------DSDFRIPNSVSND-LNPLDSNGIDTDFNKLQ--------------FKQEEEFIFEDFARLRLYGNETN 410
BLAST of slc6a-8 vs. Planmine SMEST
Match: SMESG000078454.1 (SMESG000078454.1) HSP 1 Score: 471.47 bits (1212), Expect = 5.795e-154 Identity = 253/452 (55.97%), Postives = 314/452 (69.47%), Query Frame = 3
Query: 147 KETSKVFKKSSPNGKITAYLGKRDFIDYLDYVDPVDGVVLIDPDYLKDRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASQQVYPPLNK--VEFDKTPDISNRKLTRLQERLIKKLGHNAYPFYFELPHNTPASVTLQPGPNDNGKPCGVDYELKTYVADNPDEKAHKRNSVKLAIRKLTYAPDKPSPQPSAEIVKDFIMSPGSLRLEASLDKEKYYHGESISVNVLVDNNSNKTXXXXXXAVRQHADICLYNATSYKCLVDELEFEDGFPIYSSQTGWCKVYKVCPLLSNNRDKRGLALDGKLKHEDTNLASSTIINENTNKENLGIIVQYKVKVRLVLGFGTSDISLELPFTLSHPKPADEEPNMSNFTFEDLHSNKSKIQSPEIISKTDVNTESNVPNDKLLESDSRIIDPDLIQLDTSCDNRNHTNKENILSADDDLIFEDFARLRL 1496
K ++VFKKSS NGKIT Y+GKRD+++ D++DP+DGVVLIDPDY+KDR+VFVHVLAAFRYGREDLDVLGLTFRKDLYL QQ+YP + + DK D SN LTRLQ RL++KLG NAY FYF LP N+PASVTLQP P D GKPCGVDYELK YVA + ++K KR+ VKLAIRKLT+A + P+ P+ EI+K+F +S G + ++ASLDK+ Y+HGESISV V VDN+S KTIKKIK+ V Q ADI L+ YKC++DE+E E FPI QTGW + +CPLLSNNR KRGLALDGKL+HEDTNLASST++ N E+LGIIV YKV+++L+LGF +SDI LELPF L+HP P E +++ T++ L K+ + T DN + + DDDLIF DFARL+L
Sbjct: 8 KGGTRVFKKSSLNGKITVYIGKRDYLERNDHIDPIDGVVLIDPDYVKDRRVFVHVLAAFRYGREDLDVLGLTFRKDLYLDYQQLYPKIENENCDLDKQQDQSN-SLTRLQARLMQKLGTNAYAFYFNLPRNSPASVTLQPAPEDVGKPCGVDYELKVYVAKSFEDKTQKRSCVKLAIRKLTFAFNGPNIPPTDEIIKEFRLSSGKVIMDASLDKQTYFHGESISVTVSVDNSSTKTIKKIKLQVLQIADIMLFTRAVYKCVIDEVESEKFFPINPGQTGWNVTFSMCPLLSNNRHKRGLALDGKLRHEDTNLASSTVVQSKDNIEDLGIIVSYKVRIKLILGFTSSDIQLELPFNLTHPNP---EEDLTVNTYDGLDIFKNSL--------------------------------------TFTDNYEPISSQ--AEQDDDLIFVDFARLKL 415
BLAST of slc6a-8 vs. Planmine SMEST
Match: SMESG000072792.1 (SMESG000072792.1) HSP 1 Score: 350.903 bits (899), Expect = 2.969e-114 Identity = 178/354 (50.28%), Postives = 252/354 (71.19%), Query Frame = 2
Query: 2060 SIIGFAVDFSNVFRFPYICFQNGGGAFLIPYFVTLLLCALPMFYIELLFGQYMRCGGLTIWKICPLFKGVGYASVLLNFYVALYYNVIIAWSLYYLFVSFSPTLPWTVCDKWWNSENCYFISNYLSLLEKNNNTNM--FTDSATEYLENNVLMVNQSSGIGNLGPLKWNMAXXXXXXXXXXXXXXFKGVKFLGKAVWVTAILPYVVLAALLIRGVMLEGAVEGIKYFITPNFKMLLKPDVWIAAATQIFFSVGVGFSVHIAYASYNNFHTPVHNNCLIAAAVNSLTSLFSGFVIFAYLGYMSHQMRKPLEKVVNGNLTLIFIVYPLALSTLPGGNFWAVIFFLMLFNLGLDSSV 3115
SIIGFAVD +NV+RFPYICF+NGGGAFLIPYF L+ A+P+FY+EL+ GQ+ + G + IWKICPLF+GVG A +++F VALYYNVI W Y+LF SF+ +LPW C ++ +C + +YL N++ ++ S+ EY E VL V++SSGIG+LG +W + L +++I+Y+ + +G+K GK V+VT +LPYV+L LLI G+ML GA GI FITPNF +L +VWI AA QIF+SVG GF VH+AYASYN + +C+ VNS TSL +GFV+F+YLGY+S+ ++ ++ VV +L+F +YP A++T+ G +FW+++FFL+L NLGLDS++
Sbjct: 2 SIIGFAVDLANVWRFPYICFKNGGGAFLIPYFAMLVFGAVPLFYMELILGQFHQKGAIGIWKICPLFQGVGVAQNMISFIVALYYNVINGWCFYFLFKSFTYSLPWMTCHPNISTSHCINMEDYLMKNYSRNSSGAVNYSISSLEYFERVVLQVHKSSGIGDLGLPRWELVSCTLGVFVILYITIRRGIKSSGKVVYVTVLLPYVLLIVLLINGLMLPGAKNGIVRFITPNFSILAHTEVWIEAAVQIFYSVGAGFGVHLAYASYNRLNNKCFRDCVATVIVNSGTSLLAGFVVFSYLGYISYLLKDDIDNVVTHGPSLVFQIYPFAIATIRGSSFWSIMFFLLLINLGLDSAM 355 HSP 2 Score: 83.1889 bits (204), Expect = 2.969e-114 Identity = 69/213 (32.39%), Postives = 118/213 (55.40%), Query Frame = 1
Query: 3160 GALEALLTGILDEFDFVFKKMKYKREITTAVMLTILYFLSLPNTTYGGFFLIQLYDKYSAGPSLLAVSLLECIGFIWIYGIDNTADIIKQMNGFDLHIIFRILFKYITPFAILAITIAQLFTDE-------IFTVNLGTRTYTYPQWXXXXXXXXXXXXXXXXXXFGGVVLYRIKATSWKERICLSISPNWEHRDIRSKTQFNRLKINHWITV 3777
G +E+++TG+ D +K +K +R++ + ++L + S+P T GG ++ L D+++AG SLL +L++ IG W YG++ KQM G+ I +RI +K++ P ILAI I + F L + Y +P WS+IIG ISLSS++MIPIF + I ++ + +I+P WE + ++ R ++ HWI++
Sbjct: 356 GGIESVVTGLHDVIPIHWKIIK-RRDVLSLIVLIFAFLGSIPVVTNGGIYVFTLLDRHAAGTSLLFGALMQAIGVAWFYGLNQFCSDCKQMLGYSPSIFWRICWKFLAPSFILAIVICSTVSMTRLSYPFGCFHPELNMKEYEFPSWSVIIGWGISLSSMIMIPIFA--IWNWIHYKNFYK----AITPIWEQD--QKFERYKRKRLAHWISM 559 The following BLAST results are available for this feature:
BLAST of slc6a-8 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of slc6a-8 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of slc6a-8 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of slc6a-8 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of slc6a-8 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of slc6a-8 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of slc6a-8 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of slc6a-8 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of slc6a-8 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of slc6a-8 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of slc6a-8 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of slc6a-8 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of slc6a-8 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of slc6a-8 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Cross References
External references for this transcript
Sequences
The following sequences are available for this feature:
transcript sequence >SMED30032979 ID=SMED30032979|Name=slc6a-8|organism=Schmidtea mediterranea sexual|type=transcript|length=4025bpback to top protein sequence of SMED30032979-orf-1 >SMED30032979-orf-1 ID=SMED30032979-orf-1|Name=SMED30032979-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=436bp MQNIELNESKLIKSHNNINNENPSNCRTIALLAENSDESKNLENHSDPQTback to top protein sequence of SMED30032979-orf-2 >SMED30032979-orf-2 ID=SMED30032979-orf-2|Name=SMED30032979-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=479bp MSNNHDVDLDDIKKQGTSKEKETSKVFKKSSPNGKITAYLGKRDFIDYLDback to top protein sequence of SMED30032979-orf-3 >SMED30032979-orf-3 ID=SMED30032979-orf-3|Name=SMED30032979-orf-3|organism=Schmidtea mediterranea sexual|type=polypeptide|length=187bp MKYKREITTAVMLTILYFLSLPNTTYGGFFLIQLYDKYSAGPSLLAVSLLback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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