Williams-Beuren syndrome chromosomal region 16 protein isoform X1
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30032953 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 2
Homology
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Human
Match: RCC1L (RCC1 like [Source:HGNC Symbol;Acc:HGNC:14948]) HSP 1 Score: 204.527 bits (519), Expect = 1.945e-59 Identity = 138/403 (34.24%), Postives = 216/403 (53.60%), Query Frame = 2
Query: 239 VFGVASTGALGIKRLI----NNERIKNLHIARRVYPLYYFNDLVNFQKISIRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGL-QPHSSNINGFPILMEPSEIPLP---EKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIK-FDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKS-KVVRVACGVKYSAAITSYGSLYVWGNDI-----VSGAYNQTFPVRMPA-TFHAKT 1399
V+G + +GALG+ + RR+ P+ Y +L QKIS AA GYGFTL S K++ V+G G+N DSQLG + G+ ++EPS + LP + + ++CG HS+++ T+ + ++++GNN +GQCGR++++NEIY S +H ++ FD + QV CG+ + LT+ G VY CG GQ SS ++ G + V Q++ + LA++ DG ++GWGN+E+ + S D + P L+ +GKV Q + G T CA+L+ +G + WG I+G GPN + P +IP FG L + N +V R+ CG+ + AA+T+ G L+VWG +I + +Q FP R PA + AKT
Sbjct: 63 VWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELD--QKIS--SAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVSCGRAHSLVL-------TDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHF-SGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFG----LTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRAPAPSASAKT 449
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Human
Match: RCC1L (RCC1 like [Source:HGNC Symbol;Acc:HGNC:14948]) HSP 1 Score: 204.142 bits (518), Expect = 3.648e-59 Identity = 136/413 (32.93%), Postives = 217/413 (52.54%), Query Frame = 2
Query: 239 VFGVASTGALGIKRLI----NNERIKNLHIARRVYPLYYFNDLVNFQKISIRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGL-QPHSSNINGFPILMEPSEIPLP---EKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIK-FDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKS-KVVRVACGVKYSAAITSYGSLYVWGNDI-----VSGAYNQTFPVRMPATFHAKTLYMGADHSIIV 1432
V+G + +GALG+ + RR+ P+ Y +L QKIS AA GYGFTL S K++ V+G G+N DSQLG + G+ ++EPS + LP + + ++CG HS+++ T+ + ++++GNN +GQCGR++++NEIY S +H ++ FD + QV CG+ + LT+ G VY CG GQ SS ++ G + V Q++ + LA++ DG ++GWGN+E+ + S D + P L+ +GKV Q + G T CA+L+ +G + WG I+G GPN + P +IP FG L + N +V R+ CG+ + AA+T+ G L+VWG +I + +Q FP R+ + G DH + +
Sbjct: 63 VWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELD--QKIS--SAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVSCGRAHSLVL-------TDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHF-SGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFG----LTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEPVDVACGVDHMVTL 459
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Human
Match: RCC1L (RCC1 like [Source:HGNC Symbol;Acc:HGNC:14948]) HSP 1 Score: 153.68 bits (387), Expect = 2.075e-41 Identity = 102/303 (33.66%), Postives = 163/303 (53.80%), Query Frame = 2
Query: 239 VFGVASTGALGIKRLI----NNERIKNLHIARRVYPLYYFNDLVNFQKISIRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGL-QPHSSNINGFPILMEPSEIPLP---EKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIK-FDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDD 1120
V+G + +GALG+ + RR+ P+ Y +L QKIS AA GYGFTL S K++ V+G G+N DSQLG + G+ ++EPS + LP + + ++CG HS+++ T+ + ++++GNN +GQCGR++++NEIY S +H ++ FD + QV CG+ + LT+ G VY CG GQ SS ++ G + V Q++ + LA++ DG ++GWGN+E+ + S D + P L+ +GKV Q + G T CA+L+D
Sbjct: 63 VWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLEL--DQKIS--SAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVSCGRAHSLVL-------TDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHF-SGVGKVRQAACGGTGCAVLND 353
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Human
Match: RCC1L (RCC1 like [Source:HGNC Symbol;Acc:HGNC:14948]) HSP 1 Score: 91.2781 bits (225), Expect = 4.142e-21 Identity = 46/130 (35.38%), Postives = 77/130 (59.23%), Query Frame = 2
Query: 362 FQKISIRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGL-QPHSSNINGFPILMEPSEIPLP---EKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIK 739
Q+ I AA GYGFTL S K++ V+G G+N DSQLG + G+ ++EPS + LP + + ++CG HS+++ T+ + ++++GNN +GQCGR++++NEIY S +H ++
Sbjct: 31 LQQGQISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVSCGRAHSLVL-------TDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQ 153
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Human
Match: RPGR (retinitis pigmentosa GTPase regulator [Source:HGNC Symbol;Acc:HGNC:10295]) HSP 1 Score: 82.4185 bits (202), Expect = 1.219e-16 Identity = 73/255 (28.63%), Postives = 120/255 (47.06%), Query Frame = 2
Query: 575 IACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAI-FSDEDHSCTFKPIRLNLPETIGKVIQ-VSAGSTTCAILDDKGQLHTWGMYIVG-LG-PNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWG 1327
++CG HS +V T N +Y G+N +GQ G + + + +K +K ++ CG T + TE G+VY G N GQL D ++F I+ +KQ+S NT ALTEDG ++ WG+N I + + C + + TIGK + +S G A + G+L+ +G G LG PN+++ T +L+ KV++VACG +++ +T ++Y +G
Sbjct: 40 LSCGDEHSAVV-------TGNNKLYMFGSNNWGQLG--LGSKSAISKPTCVKALKPEK-VKLAACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQV------TIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRT----------PQLVSEIPEKVIQVACGGEHTVVLTE-NAVYTFG 267
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Celegans
Match: W09G3.7 (pep chromosome:WBcel235:I:13797345:13802259:-1 gene:WBGene00012370.1 transcript:W09G3.7a.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:W09G3.7) HSP 1 Score: 144.05 bits (362), Expect = 7.623e-38 Identity = 112/412 (27.18%), Postives = 195/412 (47.33%), Query Frame = 2
Query: 245 GVASTGALGIKRLINNERIKNLHIARRVYPLYYFNDLVNFQKISIRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGLQPHSSNINGFP---ILMEPSEIPLPEKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGS--SVIHGIKF--DKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLN----LPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGNDIVSG-----AYNQTFPVRMPATFHAKTLYMGADHSIIV 1432
G++++GAL I +L+ N AR + YFN SI+ ++G+GF+LF+ K+ +YG G+N+ Q+G Q +NIN + I + IP E ++ I+ G HS+I N ++ +G+N FGQCGR + + GS S + + F +PI + C T+F++ G+V+ G N+ GQ + G ++ G +E ++++S +T+LA +E+GE++ WG E+ D I+LN + ++G +I V + ++ + +G + WG+ ++G+GP K PT + P F G V V+ G +AI G L++WG + S Q FP ++ + +G DHS+ +
Sbjct: 30 GLSASGALAIPKLVANSDDVTAGEARFPKRIAYFN------TKSIKFISSGFGFSLFASKN----RLYGAGINNRFQIGGQ--LTNINKYQDYYISAKKINIPGDEILE----ISSGRAHSLI--------RTNLGVFAIGDNNFGQCGRNPENMDYVVGSEESPLLPLSFPTSEPIISIHCSMDTSFVVDSSGAVFSFGLNEDGQCGNEAYGIQWEPAKVRGDVEGSKIQKVSGSTDTLLACSENGEIFIWGQTEYGQAAGATDE------IQLNTSRHVANSLGPIICVDSTQSSVVARNSRGNVFVWGVGVLGMGPEAESLKTPTQMDQPLFDG---------KMVTSVSAGNSCMSAINEDGRLFIWGENRYSSLGLGHQKRQLFPYQLFLPGDVRKAALGPDHSLFL 402
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Celegans
Match: W09G3.7 (pep chromosome:WBcel235:I:13797345:13802221:-1 gene:WBGene00012370.1 transcript:W09G3.7a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:W09G3.7) HSP 1 Score: 144.05 bits (362), Expect = 7.623e-38 Identity = 112/412 (27.18%), Postives = 195/412 (47.33%), Query Frame = 2
Query: 245 GVASTGALGIKRLINNERIKNLHIARRVYPLYYFNDLVNFQKISIRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGLQPHSSNINGFP---ILMEPSEIPLPEKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGS--SVIHGIKF--DKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLN----LPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGNDIVSG-----AYNQTFPVRMPATFHAKTLYMGADHSIIV 1432
G++++GAL I +L+ N AR + YFN SI+ ++G+GF+LF+ K+ +YG G+N+ Q+G Q +NIN + I + IP E ++ I+ G HS+I N ++ +G+N FGQCGR + + GS S + + F +PI + C T+F++ G+V+ G N+ GQ + G ++ G +E ++++S +T+LA +E+GE++ WG E+ D I+LN + ++G +I V + ++ + +G + WG+ ++G+GP K PT + P F G V V+ G +AI G L++WG + S Q FP ++ + +G DHS+ +
Sbjct: 30 GLSASGALAIPKLVANSDDVTAGEARFPKRIAYFN------TKSIKFISSGFGFSLFASKN----RLYGAGINNRFQIGGQ--LTNINKYQDYYISAKKINIPGDEILE----ISSGRAHSLI--------RTNLGVFAIGDNNFGQCGRNPENMDYVVGSEESPLLPLSFPTSEPIISIHCSMDTSFVVDSSGAVFSFGLNEDGQCGNEAYGIQWEPAKVRGDVEGSKIQKVSGSTDTLLACSENGEIFIWGQTEYGQAAGATDE------IQLNTSRHVANSLGPIICVDSTQSSVVARNSRGNVFVWGVGVLGMGPEAESLKTPTQMDQPLFDG---------KMVTSVSAGNSCMSAINEDGRLFIWGENRYSSLGLGHQKRQLFPYQLFLPGDVRKAALGPDHSLFL 402
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Celegans
Match: herc-1 (HECT and RCC domain E3 ubiquitin ligase [Source:UniProtKB/TrEMBL;Acc:W6RY72]) HSP 1 Score: 81.6481 bits (200), Expect = 5.067e-16 Identity = 55/194 (28.35%), Postives = 92/194 (47.42%), Query Frame = 2
Query: 752 IRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGND 1333
+ V CGE T LT+DG ++ GSN GQL S I + + QIS + +++T+DG V+ WG+NEH + + + P R+ + I ++QV++GS C LD+ G++ WG G ++ P P L G +VRV G ++ A+++ G+++ WG +
Sbjct: 43 VTSVTCGEQHTVFLTKDGKMWSVGSNMDGQLGRGSRTEGSFSIYPVSWTSSAKIIQISAGRSHTVSVTDDGRVFAWGSNEHGQLGMESKFTWQGTPRRV---QEINDIVQVASGSNHCIALDEGGRVFVWGEQADGRCIHR---------PEPV-----EQLSG--VPIVRVLAGARHCLALSASGAVFTWGQN 217 HSP 2 Score: 70.4774 bits (171), Expect = 1.906e-12 Identity = 89/360 (24.72%), Postives = 145/360 (40.28%), Query Frame = 2
Query: 443 VYGCGVNHDSQLGLQPHSSNINGFPILMEPSEIPLPEKVKG---------INFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKF--DKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKV-----VKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVG-LGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGNDIV------SGAYNQTFPVRMPATF--HAKTLYMGADHSIIV--GAP 1441
+ GCG + QLG++ + S I +PE++ G + + CG H+V + T + ++++G+N GQ GR GS I+ + + I Q+ G T +T+DG V+ GSN++GQL G S F G +V + Q++ N +AL E G V+ WG D C +P + + +++V AG+ C L G + TWG G LG + + + G G VV ACG ++ +T G + +G+D + +T P + H + GA H+I + GAP
Sbjct: 5 LLGCGHTGEGQLGVR------------LSESTIQVPERIIGAPNDMDGTAVTSVTCGEQHTVFL-------TKDGKMWSVGSNMDGQLGR----GSRTEGSFSIYPVSWTSSAKIIQISAGRSHTVSVTDDGRVFAWGSNEHGQL-----GMESKFTW--QGTPRRVQEINDIVQVASGSNHCIALDEGGRVFVWGEQA--------DGRCIHRPEPVEQLSGV-PIVRVLAGARHCLALSASGAVFTWGQNNSGELGIDDLRPQTSVQHVHQMDGLG----------VVEAACGDNHTVLLTHCGRTFSFGSDALGQCGFGKKVEKRTNPTAVSDLIGSHVTRIAAGACHTIAICKGAP 315
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Celegans
Match: herc-1 (HECT and RCC domain E3 ubiquitin ligase [Source:UniProtKB/TrEMBL;Acc:W6RY72]) HSP 1 Score: 81.6481 bits (200), Expect = 5.067e-16 Identity = 55/194 (28.35%), Postives = 92/194 (47.42%), Query Frame = 2
Query: 752 IRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGND 1333
+ V CGE T LT+DG ++ GSN GQL S I + + QIS + +++T+DG V+ WG+NEH + + + P R+ + I ++QV++GS C LD+ G++ WG G ++ P P L G +VRV G ++ A+++ G+++ WG +
Sbjct: 43 VTSVTCGEQHTVFLTKDGKMWSVGSNMDGQLGRGSRTEGSFSIYPVSWTSSAKIIQISAGRSHTVSVTDDGRVFAWGSNEHGQLGMESKFTWQGTPRRV---QEINDIVQVASGSNHCIALDEGGRVFVWGEQADGRCIHR---------PEPV-----EQLSG--VPIVRVLAGARHCLALSASGAVFTWGQN 217 HSP 2 Score: 70.4774 bits (171), Expect = 1.906e-12 Identity = 89/360 (24.72%), Postives = 145/360 (40.28%), Query Frame = 2
Query: 443 VYGCGVNHDSQLGLQPHSSNINGFPILMEPSEIPLPEKVKG---------INFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKF--DKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKV-----VKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVG-LGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGNDIV------SGAYNQTFPVRMPATF--HAKTLYMGADHSIIV--GAP 1441
+ GCG + QLG++ + S I +PE++ G + + CG H+V + T + ++++G+N GQ GR GS I+ + + I Q+ G T +T+DG V+ GSN++GQL G S F G +V + Q++ N +AL E G V+ WG D C +P + + +++V AG+ C L G + TWG G LG + + + G G VV ACG ++ +T G + +G+D + +T P + H + GA H+I + GAP
Sbjct: 5 LLGCGHTGEGQLGVR------------LSESTIQVPERIIGAPNDMDGTAVTSVTCGEQHTVFL-------TKDGKMWSVGSNMDGQLGR----GSRTEGSFSIYPVSWTSSAKIIQISAGRSHTVSVTDDGRVFAWGSNEHGQL-----GMESKFTW--QGTPRRVQEINDIVQVASGSNHCIALDEGGRVFVWGEQA--------DGRCIHRPEPVEQLSGV-PIVRVLAGARHCLALSASGAVFTWGQNNSGELGIDDLRPQTSVQHVHQMDGLG----------VVEAACGDNHTVLLTHCGRTFSFGSDALGQCGFGKKVEKRTNPTAVSDLIGSHVTRIAAGACHTIAICKGAP 315
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Celegans
Match: glo-4 (X-linked retinitis pigmentosa GTPase regulator homolog [Source:UniProtKB/Swiss-Prot;Acc:Q5DX34]) HSP 1 Score: 69.3218 bits (168), Expect = 4.352e-12 Identity = 74/277 (26.71%), Postives = 111/277 (40.07%), Query Frame = 2
Query: 563 GINFIACGLGHSVIVAEIDAID-------------------TNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQL-ASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPNKIVCKQPTVIPAPFFG--GGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWG 1327
G F CG+GHS +A + +D ++ ++T G +GQ G +N + ++G+ + Q+ CG T +LT+ G V CGS YGQ+ DI +F + G V+ I+ + +TED V+ WG N P L + + K I+ A L + + G P ++ P IP G LDGN +V VACG+ +SA ITS G+LY WG
Sbjct: 796 GNRFGQCGVGHSFRIANLHQVDGDWPAIEKIACGQFHSAFICSDGSLWTFGWGVWGQLGHGGRNNSNQLVPTRVNGLICK--VTQIACGRAHTVVLTDTGRVLVCGSGSYGQMGVDDDIKKVFAFTPLPLGPLR--VRDIATHYYHSICITEDNRVFEWGRN----------------PQELKMRMFVMKKIR-------SAQLKNTEDPSSPSPSTNGSTP-RVNLNLPAEIPREDLGLREVKHFLDGN---IVSVACGLSHSALITSEGTLYTWG 1041
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Fly
Match: CG3862 (gene:FBgn0031286 transcript:FBtr0078038) HSP 1 Score: 204.527 bits (519), Expect = 1.209e-59 Identity = 135/441 (30.61%), Postives = 217/441 (49.21%), Query Frame = 2
Query: 188 TEIYDYS--TNPPKNSYLGVFGVASTGALGIKRLINNERIKNLHIARRVYPLYYFNDLVNFQKISIRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGLQ--PHSSNINGFPILMEPSEIPLPEKVKG-------INFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIK------FDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFK-PIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGNDI-----VSGAYNQTFPVRMPATFHAKTLYMGADHSIIVGAP 1441
++I +YS T + V+G TGALG++ + + + + L + N+ I A GYGFT+++ G ++G G+N DSQLG Q + ++ +++ P+ I LP +V+G + ++ G H V++ T N I+TLGNN +GQCGR II+ E Y S++IH I + + QVECG+ + LT+ G +Y CG GQ + I G +E + + ++SC + VLAL E G+ +GWGN+E+ + E P L L ++IGK+ V+AG + C L+D+G ++TWG I+G GP +P + P FG R N++ VV + CGV + A+ S G L++WG + + +Q FP + + G DH+I + P
Sbjct: 29 SKIKEYSPKTTDSHEHRVYVWGFQETGALGLQTNVKKAKERYTEMVHHPTRLQFSNN------NEITDVAAGYGFTVYAVNRDDGETLFGSGLNTDSQLGFQVKGNPNDPANLDVIIYPTAIKLP-RVQGETDEDMRVKSMSAGRAHLVVL-------TQNGTIFTLGNNSYGQCGRSIIEEERYSKSALIHRISQEDICGKEDEVVQVECGQDHSMFLTKKGRIYTCGWGADGQTGQGNYHTAGQITLIGGDVEKEKIVRLSCSSDCVLALNEAGDAFGWGNSEYGQLDDSELAETQINIPRALKLTKSIGKIKDVAAGGSFCMALNDQGLVYTWGFGILGFGPFVEQTSKPQHLLPPLFG---RNDFSNETTVVSIGCGVFHMGAVNSDGDLFMWGKNRFGHLGLGHKKDQFFPFKAAINGKVTKVAYGVDHTIALCKP 452
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Fly
Match: Herc4 (gene:FBgn0035207 transcript:FBtr0310555) HSP 1 Score: 80.4925 bits (197), Expect = 1.755e-15 Identity = 74/259 (28.57%), Postives = 118/259 (45.56%), Query Frame = 2
Query: 644 IYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLAS---SDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKP--IRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVG-LG---PNKIV-CKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGNDI-----VSGAYNQTFPVRM 1375
+Y G+ GQ G I++E S I D ++QV CG T LT G VY CGSN Y QL + S F+ I +++ V+ QI C LAL++ G+V WG+N+ + D P +R + +T V+Q++ G+ L G+L++WG I G LG PN + C P RL + +ACG +S I+ G+++ WG + ++ N+++P ++
Sbjct: 7 LYCWGSTSHGQLGLGGIEDEQILTPSQIPWTP-DTAVQQVACGHRHTLFLTATGKVYACGSNDYSQLGHDLPTKRPRMSPFLLIP-ELQDYVIIQICCGSRHSLALSDWGQVLSWGDNDCGQLGHATDKEIVQLPKVVRQLVTKT---VVQIACGNNHSLALTSCGELYSWGSNIYGQLGVNSPNDLTHCNYPL-----------RLTTLLGIPLAAIACGGNHSFLISKSGAVFGWGRNNCGQLGLNDETNRSYPTQL 249 HSP 2 Score: 77.0258 bits (188), Expect = 1.997e-14 Identity = 86/329 (26.14%), Postives = 151/329 (45.90%), Query Frame = 2
Query: 374 SIRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGLQPHSSNINGFPILMEPSEIPLPEKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQL---ASSDIGCCSSFIQITG--GIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHT-----WGMYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAIT-SYGSLYVWG 1327
++++ A G+ TLF + VY CG N SQLG + P L+ P L + V I I CG HS+ +++ + + G+N GQ G D EI + V+ + K + Q+ CG + LT G +Y GSN YGQL + +D+ C+ +++T GI + I+C N +++ G V+GWG N + +++ + ++ P +L T+G V V+ G L ++G + T +G G N+++ + +++ S + +VACG +++ A+ S G +Y +G
Sbjct: 41 AVQQVACGHRHTLFLTATG---KVYACGSNDYSQLGHDLPTKRPRMSPFLLIPE---LQDYV--IIQICCGSRHSLALSDWGQ-------VLSWGDNDCGQLG-HATDKEIVQLPKVVRQL-VTKTVVQIACGNNHSLALTSCGELYSWGSNIYGQLGVNSPNDLTHCNYPLRLTTLLGIP---LAAIACGGNHSFLISKSGAVFGWGRNNCGQLGLNDETNRSY-PTQLKTLRTLG-VRFVACGDEFSVFLTNEGGVFTCGAGAYGQLGHGFSSNEMLPRM--------------VMELMGSTITQVACGNRHTLALVPSRGRVYAFG 333
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Fly
Match: HERC2 (gene:FBgn0031107 transcript:FBtr0301344) HSP 1 Score: 80.1073 bits (196), Expect = 2.495e-15 Identity = 77/258 (29.84%), Postives = 112/258 (43.41%), Query Frame = 2
Query: 554 KVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECG--EVTTFILTEDGSVYGCGSNQYGQLA--SSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIG-----KVIQVSAGSTTCAILDDKGQLHTWGMYIVGL--GPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAA 1294
+ K I +ACG HS AI + ++ YT G ++G+ G DN ++ + + + QV CG + T LTEDG+V+ G +G+L S+ I+ GI V QI C LALT GEVW WG ++ + D + P+ IG +VI V+ G+ C + D GQ++ WG G N V K+P ++ LD V RVACG +S A
Sbjct: 3123 RAKKIRDVACGSSHSA------AISSQGEL-YTWGLGEYGRLGHG--DNTTQLKPKLVTALA-GRRVVQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEGSDTPHEIERLSGIG---VVQIECGAQFSLALTRAGEVWTWGKGDYYRLGHGGDQ-------HVRKPQPIGGLRGRRVIHVAVGALHCLAVTDAGQVYAWGDNDHGQQGSGNTFVNKKPALVIG---------LDA--VFVNRVACGSSHSIA 3349 HSP 2 Score: 67.3958 bits (163), Expect = 2.790e-11 Identity = 83/324 (25.62%), Postives = 138/324 (42.59%), Query Frame = 2
Query: 353 LVNFQKISIRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGLQPHSSNINGFPILMEPSEIPLPEKVKGINF--IACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECG--EVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNE-HNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVG-LGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSK-VVRVACGVKYSAAITS 1303
L + Q + ++K A G ++ G VY G D +LG H + M L E + G++ IACG HS AI + ++ T G ++G+ G D+E ++ + + I + CG + T +T+D +V+ G YG+L C +I VVK + C +ALT+ G V+ WG + H DH +P ++ + K+I ++ GS C D G+++TWG G LG + T I P RL+ + K +V+V CG ++ A+++
Sbjct: 4128 LGSLQHVFVKKVAVNSGGKHCLALTTEG-EVYAWGEGEDGKLG---HGNR-------MSYDRPKLVEHLNGMSVADIACGSAHSA------AITASGHVL-TWGKGRYGRLGHG--DSEDQLRPKLVEALLGYRAI-DIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVK-VECGSQFSVALTKSGAVYTWGKGDFHRLGHGSVDH--VRRPKKVAALQG-KKIISIATGSLHCVACSDSGEVYTWGDNDEGQLGDGTV-----TAIQRP------RLVAALQGKHIVKVTCGSAHTLALST 4415 HSP 3 Score: 65.4698 bits (158), Expect = 9.461e-11 Identity = 59/202 (29.21%), Postives = 95/202 (47.03%), Query Frame = 2
Query: 746 KPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRC--NTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGM---YIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVK--YSAAITSYGSLYVWGN 1330
+PI + G + FI+++DG VY CG G+L Q+ + VVK+++ LALT DG+V+ WG E + + T RL K+ V+ GS+ A + +G+L+TWG+ +G G N K P ++ A L G +VV+VACG + + A+T G+++ WG+
Sbjct: 3020 RPI-HIAGGSKSLFIVSQDGKVYACGEGTNGRLGLGVTHNVPLPHQLP-VLRQYVVKKVAVHSGGKHALALTLDGKVFSWGEGEDGKL--GHGNRTTLDKPRLVEALRAKKIRDVACGSSHSAAISSQGELYTWGLGEYGRLGHGDNTTQLK-PKLVTA---------LAGR--RVVQVACGSRDAQTLALTEDGAVFSWGD 3205 HSP 4 Score: 51.9878 bits (123), Expect = 1.707e-6 Identity = 39/132 (29.55%), Postives = 67/132 (50.76%), Query Frame = 2
Query: 944 LALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPNKIVCKQPTVIPAPFFGGG-SRLLDGNKSK-VVRVACGVKYSAAITSYGSLYVWGND 1333
LALT +G V+ WG+ ++ + + + + + +PI L E++ +V +V AGS L +GQL+TWG K C ++ G RL+ + K +V VA V + A++S G ++ WG +
Sbjct: 735 LALTSEGLVFAWGDGDYGKL-GNGNCNGSLQPI---LVESLPRVQRVFAGSQFSVALSSEGQLYTWG---------KATCLGHQLVERSVQGCSVPRLVSSLQHKRIVDVAVSVAHCLALSSSGEVFGWGRN 853
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Fly
Match: Herc4 (gene:FBgn0035207 transcript:FBtr0072670) HSP 1 Score: 79.7221 bits (195), Expect = 2.932e-15 Identity = 72/256 (28.12%), Postives = 116/256 (45.31%), Query Frame = 2
Query: 644 IYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKP--IRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVG-LG---PNKIV-CKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGNDI-----VSGAYNQTFPVRM 1375
+Y G+ GQ G I++E S I D ++QV CG T LT G VY CGSN Y QL D+ + +++ V+ QI C LAL++ G+V WG+N+ + D P +R + +T V+Q++ G+ L G+L++WG I G LG PN + C P RL + +ACG +S I+ G+++ WG + ++ N+++P ++
Sbjct: 7 LYCWGSTSHGQLGLGGIEDEQILTPSQIPWTP-DTAVQQVACGHRHTLFLTATGKVYACGSNDYSQLG-HDLPTKRPL--LIPELQDYVIIQICCGSRHSLALSDWGQVLSWGDNDCGQLGHATDKEIVQLPKVVRQLVTKT---VVQIACGNNHSLALTSCGELYSWGSNIYGQLGVNSPNDLTHCNYPL-----------RLTTLLGIPLAAIACGGNHSFLISKSGAVFGWGRNNCGQLGLNDETNRSYPTQL 244 HSP 2 Score: 73.559 bits (179), Expect = 2.503e-13 Identity = 85/329 (25.84%), Postives = 149/329 (45.29%), Query Frame = 2
Query: 374 SIRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGLQPHSSNINGFPILMEPSEIPLPEKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQL---ASSDIGCCSSFIQITG--GIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHT-----WGMYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAIT-SYGSLYVWG 1327
++++ A G+ TLF + VY CG N SQLG + P P IP + I I CG HS+ +++ + + G+N GQ G D EI + V+ + K + Q+ CG + LT G +Y GSN YGQL + +D+ C+ +++T GI + I+C N +++ G V+GWG N + +++ + ++ P +L T+G V V+ G L ++G + T +G G N+++ + +++ S + +VACG +++ A+ S G +Y +G
Sbjct: 41 AVQQVACGHRHTLFLTATG---KVYACGSNDYSQLG--------HDLPT-KRPLLIPELQDYVIIQ-ICCGSRHSLALSDWGQ-------VLSWGDNDCGQLG-HATDKEIVQLPKVVRQL-VTKTVVQIACGNNHSLALTSCGELYSWGSNIYGQLGVNSPNDLTHCNYPLRLTTLLGIP---LAAIACGGNHSFLISKSGAVFGWGRNNCGQLGLNDETNRSY-PTQLKTLRTLG-VRFVACGDEFSVFLTNEGGVFTCGAGAYGQLGHGFSSNEMLPRM--------------VMELMGSTITQVACGNRHTLALVPSRGRVYAFG 328
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Fly
Match: Herc4 (gene:FBgn0035207 transcript:FBtr0072671) HSP 1 Score: 79.7221 bits (195), Expect = 2.932e-15 Identity = 72/256 (28.12%), Postives = 116/256 (45.31%), Query Frame = 2
Query: 644 IYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKP--IRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVG-LG---PNKIV-CKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGNDI-----VSGAYNQTFPVRM 1375
+Y G+ GQ G I++E S I D ++QV CG T LT G VY CGSN Y QL D+ + +++ V+ QI C LAL++ G+V WG+N+ + D P +R + +T V+Q++ G+ L G+L++WG I G LG PN + C P RL + +ACG +S I+ G+++ WG + ++ N+++P ++
Sbjct: 7 LYCWGSTSHGQLGLGGIEDEQILTPSQIPWTP-DTAVQQVACGHRHTLFLTATGKVYACGSNDYSQLG-HDLPTKRPL--LIPELQDYVIIQICCGSRHSLALSDWGQVLSWGDNDCGQLGHATDKEIVQLPKVVRQLVTKT---VVQIACGNNHSLALTSCGELYSWGSNIYGQLGVNSPNDLTHCNYPL-----------RLTTLLGIPLAAIACGGNHSFLISKSGAVFGWGRNNCGQLGLNDETNRSYPTQL 244 HSP 2 Score: 73.559 bits (179), Expect = 2.503e-13 Identity = 85/329 (25.84%), Postives = 149/329 (45.29%), Query Frame = 2
Query: 374 SIRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGLQPHSSNINGFPILMEPSEIPLPEKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQL---ASSDIGCCSSFIQITG--GIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHT-----WGMYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAIT-SYGSLYVWG 1327
++++ A G+ TLF + VY CG N SQLG + P P IP + I I CG HS+ +++ + + G+N GQ G D EI + V+ + K + Q+ CG + LT G +Y GSN YGQL + +D+ C+ +++T GI + I+C N +++ G V+GWG N + +++ + ++ P +L T+G V V+ G L ++G + T +G G N+++ + +++ S + +VACG +++ A+ S G +Y +G
Sbjct: 41 AVQQVACGHRHTLFLTATG---KVYACGSNDYSQLG--------HDLPT-KRPLLIPELQDYVIIQ-ICCGSRHSLALSDWGQ-------VLSWGDNDCGQLG-HATDKEIVQLPKVVRQL-VTKTVVQIACGNNHSLALTSCGELYSWGSNIYGQLGVNSPNDLTHCNYPLRLTTLLGIP---LAAIACGGNHSFLISKSGAVFGWGRNNCGQLGLNDETNRSY-PTQLKTLRTLG-VRFVACGDEFSVFLTNEGGVFTCGAGAYGQLGHGFSSNEMLPRM--------------VMELMGSTITQVACGNRHTLALVPSRGRVYAFG 328
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Zebrafish
Match: rcc1l (RCC1 like [Source:ZFIN;Acc:ZDB-GENE-060526-370]) HSP 1 Score: 204.142 bits (518), Expect = 1.750e-59 Identity = 136/437 (31.12%), Postives = 224/437 (51.26%), Query Frame = 2
Query: 158 KRATKDYIRNTEIYDY-STNPPKNSYLGVFGVASTGALGIKRLINNERIKNLHIARRVYPLYYFNDLVNFQKISIRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGLQP---HSSNINGFPILMEPSEIPL--PEKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIK-FDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGNDI-----VSGAYNQTFPVRMPATFHAKTLYMGADHSIIV 1432
KR +D + +Y Y N + V+G + TGALGI + + + ++ P L QKIS AA GYGFTL + + ++G G+N DSQLG Q S + + P +PL P++ + + ++CG HS+++ T+++ ++++G+N FGQCGR+I+++E+Y GS V+H I+ FD + QV CG+ + LT+ GSV+ CG GQ S + + G + V+Q++ + LA++ DG+V+GWGN+E+ + S + + P L L + +G++ Q + G T A+L++ G + WG I+G GP P +PA FFG R KV + CG+ + AA+T G L+VWG ++ + +Q FP R+ H + G DH + +
Sbjct: 31 KREQQD---DVPVYQYVGQNRKPQGKVFVWGFSYTGALGIPSFVVPDSGRKKPRKTQLTPYC----LDTEQKIS--SAACGYGFTLLASNTKDLTKLWGMGLNKDSQLGFQRTQHDKSKSYDYVLEASPVSLPLLNPQETRVLQ-VSCGRAHSLVL-------TDSEGVFSMGSNTFGQCGRKIVEDEVYSGSHVVHKIEGFDSRVIQVACGQDHSLFLTDRGSVFACGWGADGQTGLGHHNKASCPVPVGGDLAGVTVQQVATYGDCSLAVSTDGQVFGWGNSEYLQLASVTESTQISSPRLLPL-KGVGRIRQAACGGTQVAVLNEDGDVFVWGFGILGKGPKLSESAIPERVPATFFG---RSEFNPTVKVASIRCGLSHFAAVTDGGELFVWGKNVRGCLGIGKHDDQYFPWRVTVPGHVTDVACGVDHMVAL 446
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Zebrafish
Match: rcbtb2 (regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 [Source:ZFIN;Acc:ZDB-GENE-071016-3]) HSP 1 Score: 78.5666 bits (192), Expect = 5.531e-15 Identity = 83/298 (27.85%), Postives = 133/298 (44.63%), Query Frame = 2
Query: 443 VYGCGVNHDSQLGLQPHSSNINGFPILMEPSEIPLPEKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVG-LGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRV-ACGVKY-SAAITSYGSLYVWG 1327
V+ G N LGL S I EP I + K I+ ++ G G V++A D +Y G+N + Q G ++ + +++ K + +V CG T LT DG VY G N GQ+ S + +++ ++NKVV I+C +A+ ++GE +GWG N N ++ P R+ + I +IQV+ G L D+G +++WG G LG K +P L++ +K ++V V AC + SAA T G + +WG
Sbjct: 43 VFALGTNCSGCLGLGDTQSTI-------EPRRIDILCGKKIIS-LSYGTGPHVVIATADGE------VYAWGHNGYSQLGNGTTNHGL--TPALVSTNLIGKRVTEVSCGSHHTIALTTDGEVYAWGYNNSGQVGSGSTANQPTPRRVSSCLQNKVVVNIACGQLCSMAVLDNGETYGWGYN-CNGQLGLGNNGNQQTPCRIAALQGI-NIIQVACGYAHTLALTDEGFVYSWGANSYGQLGTGN---KSNQAVPT--------LINMDKERMVEVAACHTSHTSAAKTQSGQVLMWG 311
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Zebrafish
Match: herc2 (HECT and RLD domain containing E3 ubiquitin protein ligase 2 [Source:ZFIN;Acc:ZDB-GENE-070718-6]) HSP 1 Score: 79.337 bits (194), Expect = 6.512e-15 Identity = 80/297 (26.94%), Postives = 128/297 (43.10%), Query Frame = 2
Query: 443 VYGCGVNHDSQLGLQPHSSNIN-GFPILMEPSEIPLPEKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECG--EVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETI-----GKVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPN--KIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITS 1303
V+ G D +LG H S +N P L+E K K I IACG HS + T++ +Y+ G ++G+ G DN ++ + + QV CG + T LT++G V+ G +G+L C+ Q + + V QI C LALT+ G VW WG ++ + D + + P+ + K++ V+ G+ C + + GQ+ WG G N V ++PT++ L+G K + RVACG +S A T+
Sbjct: 3062 VFSWGEGDDGKLG---HFSRMNCDKPRLIEAL------KTKRIRDIACGSSHSAAI-------TSSGELYSWGLGEYGRLGHG--DNTTQLRPKLVK-VLLGHRVVQVACGSRDAQTLALTDEGMVFSWGDGDFGKLGRGGSEGCN-IPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGTD-------VHVRKPQMVEGLRGKKIVHVAVGALHCLAVTETGQVFAWGDNDHGQQGNGTTTVNRKPTLVQG---------LEGQK--ITRVACGSSHSVAWTT 3320 HSP 2 Score: 71.633 bits (174), Expect = 1.541e-12 Identity = 62/255 (24.31%), Postives = 114/255 (44.71%), Query Frame = 2
Query: 560 KGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECG--EVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWG-----MYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITS 1303
K + IACG +S + T + ++T G +G+ G +E ++ +K K I V CG + T +TE+G V+ G YG+L C + ++ +++ + ++ C +ALT+DG+V+ WG ++ + D + + +L +V+ ++ GST C L ++G++H+WG + L NK KQP +P N +V ++CG S + +S
Sbjct: 541 KQVVHIACGSTYSAAI-------TADGELHTWGRGNYGRLGHG--SSEDQTTPMLVTALKGLKVI-DVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKT-PKLVEKLQDLDIVKVCCGSQFSVALTKDGQVYTWGKGDNQRLGHGTDEHVRYPKLLDSLQGK--RVVDIAVGSTHCLALTEEGEVHSWGSNDKLQHFDTLFSNK---KQPKALPGL-----------NSKHIVGISCGPGQSFSWSS 768 HSP 3 Score: 70.4774 bits (171), Expect = 3.437e-12 Identity = 86/325 (26.46%), Postives = 142/325 (43.69%), Query Frame = 2
Query: 353 LVNFQKISIRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGLQPHSSNINGFPILMEPSEIP-LPEKVKGINF--IACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECG--EVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAI-FSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVG-LGPNKI-VCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITS 1303
L + Q + IRK A G SS G +Y G D +LG H + P + P + E ++G+ IA G HS + T + +YT G ++G+ G D+E ++ ++ + I V CG + T LT+D V+ G YG+L C ++I VVK + C +ALT+ G V+ WG +++ + +DH +P ++ + KVI ++ GS C + G+++TWG G LG ++P ++ A L G K+ RVACG ++ A ++
Sbjct: 4027 LESIQHVFIRKVAVNSGGKHCLALSSEG-ELYSWGEAEDGKLG---HGNR--------SPCDRPRVIESLRGVEVVDIAAGGAHSACI-------TASGELYTWGKGRYGRLGHG--DSEDQLKPKLVEALQGHRVI-DVACGSGDAQTLCLTDDDMVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVK-VECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDH--VRRPRQVQGLQG-KKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAA---------LQGK--KINRVACGSAHTLAWST 4314 HSP 4 Score: 67.781 bits (164), Expect = 2.960e-11 Identity = 75/324 (23.15%), Postives = 130/324 (40.12%), Query Frame = 2
Query: 443 VYGCGVNHDSQLGLQPHSSNINGFPILMEPSEIPLPEKVKGI-NFIACGL-----GHSVIVAEIDAIDTNNQIIYTLG---NNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVK--------QISC--RCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGK-----VIQVSAGSTTCAILDDKGQLHTWG---MYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGND 1333
VY CG + +LGL + IP+P ++ + N++ + G + +D +++ G + K G R D +I +K K IR + CG + +T G +Y G +YG+L D T + K+VK Q++C R LALT++G V+ WG+ + + C N+P+ I + V Q+ G+ L G + TWG + +G G + + ++P ++ L G K+V VA G + A+T G ++ WG++
Sbjct: 3007 VYACGEATNGRLGLG------------LSSGTIPIPRQISALSNYVVKKVAVHSGGRHAMALTVDGK------VFSWGEGDDGKLGHFSRMNCDK-----PRLIEALK-TKRIRDIACGSSHSAAITSSGELYSWGLGEYGRLGHGD---------NTTQLRPKLVKVLLGHRVVQVACGSRDAQTLALTDEGMVFSWGDGDFGKLGRGGSEGC-------NIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGTD-VHVRKPQMVEG---------LRGK--KIVHVAVGALHCLAVTETGQVFAWGDN 3278 HSP 5 Score: 67.3958 bits (163), Expect = 3.546e-11 Identity = 59/215 (27.44%), Postives = 96/215 (44.65%), Query Frame = 2
Query: 719 SVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIEN--KVVKQISCRCNT----VLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGM---YIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSK-VVRVACGVKYSAAITSYGSLYVWGND 1333
SV G K + + CG + +T DG ++ G YG+L G SS Q T + K +K I C + LA+TE+G+VW WG+ ++ + C + L + +++V GS L GQ++TWG +G G ++ V + P +LLD + K VV +A G + A+T G ++ WG++
Sbjct: 532 SVFSGRPVGKQVVHIACGSTYSAAITADGELHTWGRGNYGRL-----GHGSSEDQTTPMLVTALKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLVEKLQDL--DIVKVCCGSQFSVALTKDGQVYTWGKGDNQRLGHGTDEHV-RYP------------KLLDSLQGKRVVDIAVGSTHCLALTEEGEVHSWGSN 726 HSP 6 Score: 57.7658 bits (138), Expect = 3.201e-8 Identity = 53/191 (27.75%), Postives = 81/191 (42.41%), Query Frame = 2
Query: 803 GSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVK--------------QISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVG-LG-PNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWG 1327
G++YG G N GQL GGIE VK Q+ T+ A+T DG+++ G + S + + ++ + + V++G C L +G+L++WG G LG N+ C +P VI + L G +VV +A G +SA IT+ G LY WG
Sbjct: 3948 GTIYGWGHNHRGQL---------------GGIEGAKVKVPTPTEALATLRPVQLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIRKVAVNSGGKHCLALSSEGELYSWGEAEDGKLGHGNRSPCDRPRVIES---------LRG--VEVVDIAAGGAHSACITASGELYTWG 4112 HSP 7 Score: 55.0694 bits (131), Expect = 2.253e-7 Identity = 55/189 (29.10%), Postives = 84/189 (44.44%), Query Frame = 2
Query: 791 LTEDGSVYGCGSNQYGQLASSDIGCCSSFIQIT---GGIENKVVKQISCRCNTVLALTEDGEV--WGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAIL--DDKGQLHTWG---MYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWG 1327
L+ +G V+ G G+L D I+ G K V I+C A+T DGE+ WG GN S ED + P+ + + + KVI V+ GS L + GQ+ +WG +G G + CK P ++ +L D + +V+V CG ++S A+T G +Y WG
Sbjct: 500 LSVNGEVFSWGCGDGGRLGHGDTTYLEEPTMISVFSGRPVGKQVVHIACGSTYSAAITADGELHTWGRGNYGRLGHGSSEDQT---TPMLVTALKGL-KVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSD-GCKTPKLV--------EKLQDLD---IVKVCCGSQFSVALTKDGQVYTWG 672 HSP 8 Score: 53.9138 bits (128), Expect = 5.033e-7 Identity = 66/277 (23.83%), Postives = 111/277 (40.07%), Query Frame = 2
Query: 644 IYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRC--NTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIG--KVIQVSAGSTTCAILDDKGQLHTWGMYIVG----------LGPNKIVCKQP-TVIPAPFFGGGSRLL------------DGNKSK----------------------VVRVACGVKYSAAITSYGSLYVWG 1327
IY G+N GQ G I+ + + + +P+ Q+ GE T F +T DG +Y G G+L S+ + I++ +++++ LAL+ +GE++ WG E + C R + E++ +V+ ++AG A + G+L+TWG G L P + Q VI G ++ L DG+ K VV+V CG ++S A+T G++Y WG
Sbjct: 3950 IYGWGHNHRGQLGG--IEGAKVKVPTPTEALATLRPV-QLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVST-PTLLESIQHVFIRKVAVNSGGKHCLALSSEGELYSWGEAEDGKLGHGNRSPCD----RPRVIESLRGVEVVDIAAGGAHSACITASGELYTWGKGRYGRLGHGDSEDQLKPKLVEALQGHRVIDVACGSGDAQTLCLTDDDMVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWG 4218 HSP 9 Score: 53.1434 bits (126), Expect = 8.625e-7 Identity = 51/223 (22.87%), Postives = 92/223 (41.26%), Query Frame = 2
Query: 761 VECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCN--TVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWG---MYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGND----IVSGAYNQTFPVRMPATFHAKTL 1402
+ G + +T G +Y G +YG+L D ++ ++ V ++C L LT+D VW WG+ ++ + C P++++ +G V++V GS L G ++TWG + +G G + V ++P + L G K V+ +A G + T G +Y WG++ + G N R+ A K +
Sbjct: 4092 IAAGGAHSACITASGELYTWGKGRYGRLGHGD-SEDQLKPKLVEALQGHRVIDVACGSGDAQTLCLTDDDMVWSWGDGDYGKLGRGGSDGCKV-PMKIDSLTGLG-VVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHV-RRPRQVQG---------LQGKK--VIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKI 4299
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Zebrafish
Match: rpgrb (retinitis pigmentosa GTPase regulator b [Source:ZFIN;Acc:ZDB-GENE-081015-2]) HSP 1 Score: 78.1814 bits (191), Expect = 8.265e-15 Identity = 71/260 (27.31%), Postives = 118/260 (45.38%), Query Frame = 2
Query: 575 IACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAI-FSDEDHSCTFKPIRLNLPETIGK-VIQVSAGSTTCAILDDKGQLHTWGMY---IVGLGPNKI----VCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWG 1327
I+CG H+ +V E N ++ G+N +GQ G + + + +K ++ ++ CG T + T G++Y CG N GQL D +SF + + +K ++ NT ALT+DG ++ WG+N I E ++ T + + ++GK V VS G A + G L+T+G +GL K+ V +Q T IP +VV+VACG ++ A+T +Y +G
Sbjct: 41 ISCGDEHTALVTE-------NGKLFMFGSNNWGQLG--LGTKTTVNKPTCVKALKSER-VKLTACGRTHTLVFTSRGNLYACGGNNEGQLGLGDCNDRTSFHLVEFFNKQGPIKMLAAGSNTSAALTQDGRLYMWGDNSEGQIGLGKESNALTPQEV------SVGKRVFWVSCGYYHSAFVTVDGALYTFGEKDSGKLGLSTEKLANHKVPQQVTDIP---------------DRVVQVACGGGHTVALTE-NEVYSFG 268 HSP 2 Score: 62.7734 bits (151), Expect = 5.885e-10 Identity = 58/204 (28.43%), Postives = 96/204 (47.06%), Query Frame = 2
Query: 734 IKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQIT--GGIENKVVKQISCRCNTVLALTEDGEVWG-WGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYI---VGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWG 1327
+K D P+R + CG+ T ++TE+G ++ GSN +GQL +G ++ + T ++++ VK +C L T G ++ GNNE D + +F + + G + ++AGS T A L G+L+ WG +GLG K+ + G R V V+CG +SA +T G+LY +G
Sbjct: 33 LKNDVPLR-ISCGDEHTALVTENGKLFMFGSNNWGQLG---LGTKTTVNKPTCVKALKSERVKLTACGRTHTLVFTSRGNLYACGGNNEGQLGLGDCNDRTSFHLVEFFNKQ--GPIKMLAAGSNTSAALTQDGRLYMWGDNSEGQIGLG------KESNALTPQEVSVGKR--------VFWVSCGYYHSAFVTVDGALYTFG 216
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Zebrafish
Match: rpgrb (retinitis pigmentosa GTPase regulator b [Source:ZFIN;Acc:ZDB-GENE-081015-2]) HSP 1 Score: 75.485 bits (184), Expect = 9.871e-14 Identity = 71/260 (27.31%), Postives = 118/260 (45.38%), Query Frame = 2
Query: 575 IACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAI-FSDEDHSCTFKPIRLNLPETIGK-VIQVSAGSTTCAILDDKGQLHTWGMY---IVGLGPNKI----VCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWG 1327
I+CG H+ +V E N ++ G+N +GQ G + + + +K ++ ++ CG T + T G++Y CG N GQL D +SF + + +K ++ NT ALT+DG ++ WG+N I E ++ T + + ++GK V VS G A + G L+T+G +GL K+ V +Q T IP +VV+VACG ++ A+T +Y +G
Sbjct: 41 ISCGDEHTALVTE-------NGKLFMFGSNNWGQLG--LGTKTTVNKPTCVKALKSER-VKLTACGRTHTLVFTSRGNLYACGGNNEGQLGLGDCNDRTSFHLVEFFNKQGPIKMLAAGSNTSAALTQDGRLYMWGDNSEGQIGLGKESNALTPQEV------SVGKRVFWVSCGYYHSAFVTVDGALYTFGEKDSGKLGLSTEKLANHKVPQQVTDIP---------------DRVVQVACGGGHTVALTE-NEVYSFG 268 HSP 2 Score: 61.2326 bits (147), Expect = 2.757e-9 Identity = 58/204 (28.43%), Postives = 96/204 (47.06%), Query Frame = 2
Query: 734 IKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQIT--GGIENKVVKQISCRCNTVLALTEDGEVWG-WGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYI---VGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWG 1327
+K D P+R + CG+ T ++TE+G ++ GSN +GQL +G ++ + T ++++ VK +C L T G ++ GNNE D + +F + + G + ++AGS T A L G+L+ WG +GLG K+ + G R V V+CG +SA +T G+LY +G
Sbjct: 33 LKNDVPLR-ISCGDEHTALVTENGKLFMFGSNNWGQLG---LGTKTTVNKPTCVKALKSERVKLTACGRTHTLVFTSRGNLYACGGNNEGQLGLGDCNDRTSFHLVEFFNKQ--GPIKMLAAGSNTSAALTQDGRLYMWGDNSEGQIGLG------KESNALTPQEVSVGKR--------VFWVSCGYYHSAFVTVDGALYTFG 216
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Xenopus
Match: rcc1l (RCC1 like [Source:NCBI gene;Acc:493236]) HSP 1 Score: 201.83 bits (512), Expect = 1.727e-58 Identity = 132/415 (31.81%), Postives = 218/415 (52.53%), Query Frame = 2
Query: 239 VFGVASTGALGIKRLINNERIKNLHIARRVYPLYYFNDLVNFQKISIRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGL-QPHSSNINGFPILMEPSEIPLP----EKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIK-FDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPET-----IGKVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKS-KVVRVACGVKYSAAITSYGSLYVWGNDIV----SGAY-NQTFPVRMPATFHAKTLYMGADHSIIV 1432
V+G + TGALGI + E + ++ P D +KIS AA GYGFTL S K++ ++G G+N DSQ+G + G+ ++EPS IPLP ++ K + ++CG HS+I+ T+ + +++LGNN +GQC R++I+ EIY S +IH ++ D + QV CG+ + TE G VY CG GQ CS+ ++ G + + Q++ + LA++E+G+++GWGN+E+ + +C +++L + +GKV V+ G T C ++ G + WG I+G GPN + +QP +IP FG L D N +V +V G+ + AA+ + G L+VWG ++ +G + +Q FP R+ + G DH + +
Sbjct: 54 VWGFSHTGALGIPSFVIPETGRKKPKKFQLTPYRLDMD----EKIS--SAACGYGFTLLSSKTANITKIWGMGLNKDSQIGFHRSRRDRTKGYEYILEPSPIPLPLDKPQETKVLQ-VSCGRAHSLIL-------TDKEGVFSLGNNSYGQCAREVIEGEIYSESQLIHRVRELDSRVVQVACGQDHSLFRTEKGEVYSCGWGADGQTGLGHFNVCSNPTKLGGDMAGVNIVQVATYGDCCLAVSEEGQLYGWGNSEYLQL------ACVTDSTQVSLGQCTTFQHVGKVKHVACGGTGCIAVNGDGSVFVWGYGILGKGPNFLEAQQPEIIPQSLFG----LSDFNPDIRVTKVFSGLGHFAALNNRGELFVWGKNLRGCLGTGRFEDQYFPWRVTVPGEVVDVSCGVDHMVAL 444
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Xenopus
Match: rcc1l (RCC1 like [Source:NCBI gene;Acc:493236]) HSP 1 Score: 165.236 bits (417), Expect = 4.039e-46 Identity = 100/320 (31.25%), Postives = 171/320 (53.44%), Query Frame = 2
Query: 506 NGFPILMEPSEIPLP----EKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIK-FDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKS-KVVRVACGVKYSAAITSYGSLYVWGNDIV----SGAY-NQTFPVRMPATFHAKTLYMGADHSIIV 1432
G+ ++EPS IPLP ++ K + ++CG HS+I+ T+ + +++LGNN +GQC R++I+ EIY S +IH ++ D + QV CG+ + TE G VY CG GQ CS+ ++ G + + Q++ + LA++E+G+++GWGN+E+ + D + + + + +GKV V+ G T C ++ G + WG I+G GPN + +QP +IP FG L D N +V +V G+ + AA+ + G L+VWG ++ +G + +Q FP R+ + G DH + +
Sbjct: 10 KGYEYILEPSPIPLPLDKPQETKVLQ-VSCGRAHSLIL-------TDKEGVFSLGNNSYGQCAREVIEGEIYSESQLIHRVRELDSRVVQVACGQDHSLFRTEKGEVYSCGWGADGQTGLGHFNVCSNPTKLGGDMAGVNIVQVATYGDCCLAVSEEGQLYGWGNSEYLQLACVTDST---QVSQCTTFQHVGKVKHVACGGTGCIAVNGDGSVFVWGYGILGKGPNFLEAQQPEIIPQSLFG----LSDFNPDIRVTKVFSGLGHFAALNNRGELFVWGKNLRGCLGTGRFEDQYFPWRVTVPGEVVDVSCGVDHMVAL 314
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Xenopus
Match: ENSXETT00000039329.1 (HECT and RLD domain containing E3 ubiquitin protein ligase 3 [Source:NCBI gene;Acc:100488790]) HSP 1 Score: 85.8853 bits (211), Expect = 5.940e-17 Identity = 92/323 (28.48%), Postives = 145/323 (44.89%), Query Frame = 2
Query: 377 IRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGLQPHSSNINGFPILMEPSEIPLPEKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAI-FSDE---DHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVG-LGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAA-ITSYGSLYVWG 1327
+++ A G TLF + VY CG N + QLG ++ L E + I IACG H++ A+ Q +Y+ G+ GQ G +++ R +I + K I+QV CG L +DG ++ G N +GQL + S Q +E + Q++ + AL+ G V+GWGNN + +DE + C KP+R + KVI +S G AIL G L T+G G LG + + + P R+L+ S+V ++ACG +++ A + S G+LY +G
Sbjct: 36 VKEVACGGKHTLFLLEDG---QVYSCGWNGEGQLGHDHEGTDPVQVTTLTE----------EHITHIACGQSHNL------ALSYQGQ-LYSWGSGNDGQLGHATVEHS-SRIPRIIKKLNQQK-IQQVSCGNDHCMALGDDGQLFTWGQNLHGQLGLGNGFLSQSSPQRVKSLEGIPLAQVTAGGSHSFALSLSGAVFGWGNNSAGQLGLNDEKVRETPCHVKPLRTH------KVIYISCGEEHTAILTKAGGLFTFGAGGSGQLGHDSL---NNEINP-------RRVLELMGSEVSQIACGRQHTLAFVPSSGTLYAFG 320 HSP 2 Score: 77.7962 bits (190), Expect = 1.885e-14 Identity = 68/233 (29.18%), Postives = 109/233 (46.78%), Query Frame = 2
Query: 656 GNNKFGQCGRQIIDNEIYRGS---SVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGN-NEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYI---VGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGND 1333
G++ FGQ G + ++GS + +++V CG T L EDG VY CG N GQL G + +Q+T E + I+C + LAL+ G+++ WG+ N+ + +HS I L + K+ QVS G+ C L D GQL TWG + +GLG + P + + L+G + +V G +S A++ G+++ WGN+
Sbjct: 5 GHSTFGQLG----NGHSFQGSVSDPCVCRFSLAACVKEVACGGKHTLFLLEDGQVYSCGWNGEGQLGHDHEG--TDPVQVTTLTEEHIT-HIACGQSHNLALSYQGQLYSWGSGNDGQLGHATVEHSSRIPRIIKKLNQQ--KIQQVSCGNDHCMALGDDGQLFTWGQNLHGQLGLGNGFLSQSSPQRVKS---------LEG--IPLAQVTAGGSHSFALSLSGAVFGWGNN 217
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Xenopus
Match: ENSXETT00000027632.1 (HECT and RLD domain containing E3 ubiquitin protein ligase 3 [Source:NCBI gene;Acc:100488790]) HSP 1 Score: 85.8853 bits (211), Expect = 6.072e-17 Identity = 92/323 (28.48%), Postives = 145/323 (44.89%), Query Frame = 2
Query: 377 IRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGLQPHSSNINGFPILMEPSEIPLPEKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAI-FSDE---DHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVG-LGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAA-ITSYGSLYVWG 1327
+++ A G TLF + VY CG N + QLG ++ L E + I IACG H++ A+ Q +Y+ G+ GQ G +++ R +I + K I+QV CG L +DG ++ G N +GQL + S Q +E + Q++ + AL+ G V+GWGNN + +DE + C KP+R + KVI +S G AIL G L T+G G LG + + + P R+L+ S+V ++ACG +++ A + S G+LY +G
Sbjct: 36 VKEVACGGKHTLFLLEDG---QVYSCGWNGEGQLGHDHEGTDPVQVTTLTE----------EHITHIACGQSHNL------ALSYQGQ-LYSWGSGNDGQLGHATVEHS-SRIPRIIKKLNQQK-IQQVSCGNDHCMALGDDGQLFTWGQNLHGQLGLGNGFLSQSSPQRVKSLEGIPLAQVTAGGSHSFALSLSGAVFGWGNNSAGQLGLNDEKVRETPCHVKPLRTH------KVIYISCGEEHTAILTKAGGLFTFGAGGSGQLGHDSL---NNEINP-------RRVLELMGSEVSQIACGRQHTLAFVPSSGTLYAFG 320 HSP 2 Score: 77.7962 bits (190), Expect = 2.081e-14 Identity = 68/233 (29.18%), Postives = 109/233 (46.78%), Query Frame = 2
Query: 656 GNNKFGQCGRQIIDNEIYRGS---SVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGN-NEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYI---VGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGND 1333
G++ FGQ G + ++GS + +++V CG T L EDG VY CG N GQL G + +Q+T E + I+C + LAL+ G+++ WG+ N+ + +HS I L + K+ QVS G+ C L D GQL TWG + +GLG + P + + L+G + +V G +S A++ G+++ WGN+
Sbjct: 5 GHSTFGQLG----NGHSFQGSVSDPCVCRFSLAACVKEVACGGKHTLFLLEDGQVYSCGWNGEGQLGHDHEG--TDPVQVTTLTEEHIT-HIACGQSHNLALSYQGQLYSWGSGNDGQLGHATVEHSSRIPRIIKKLNQQ--KIQQVSCGNDHCMALGDDGQLFTWGQNLHGQLGLGNGFLSQSSPQRVKS---------LEG--IPLAQVTAGGSHSFALSLSGAVFGWGNN 217
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Xenopus
Match: ENSXETT00000039331.1 (HECT and RLD domain containing E3 ubiquitin protein ligase 3 [Source:NCBI gene;Acc:100488790]) HSP 1 Score: 85.8853 bits (211), Expect = 6.477e-17 Identity = 92/323 (28.48%), Postives = 145/323 (44.89%), Query Frame = 2
Query: 377 IRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGLQPHSSNINGFPILMEPSEIPLPEKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAI-FSDE---DHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVG-LGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAA-ITSYGSLYVWG 1327
+++ A G TLF + VY CG N + QLG ++ L E + I IACG H++ A+ Q +Y+ G+ GQ G +++ R +I + K I+QV CG L +DG ++ G N +GQL + S Q +E + Q++ + AL+ G V+GWGNN + +DE + C KP+R + KVI +S G AIL G L T+G G LG + + + P R+L+ S+V ++ACG +++ A + S G+LY +G
Sbjct: 36 VKEVACGGKHTLFLLEDG---QVYSCGWNGEGQLGHDHEGTDPVQVTTLTE----------EHITHIACGQSHNL------ALSYQGQ-LYSWGSGNDGQLGHATVEHS-SRIPRIIKKLNQQK-IQQVSCGNDHCMALGDDGQLFTWGQNLHGQLGLGNGFLSQSSPQRVKSLEGIPLAQVTAGGSHSFALSLSGAVFGWGNNSAGQLGLNDEKVRETPCHVKPLRTH------KVIYISCGEEHTAILTKAGGLFTFGAGGSGQLGHDSL---NNEINP-------RRVLELMGSEVSQIACGRQHTLAFVPSSGTLYAFG 320 HSP 2 Score: 77.7962 bits (190), Expect = 1.982e-14 Identity = 68/233 (29.18%), Postives = 109/233 (46.78%), Query Frame = 2
Query: 656 GNNKFGQCGRQIIDNEIYRGS---SVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGN-NEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYI---VGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGND 1333
G++ FGQ G + ++GS + +++V CG T L EDG VY CG N GQL G + +Q+T E + I+C + LAL+ G+++ WG+ N+ + +HS I L + K+ QVS G+ C L D GQL TWG + +GLG + P + + L+G + +V G +S A++ G+++ WGN+
Sbjct: 5 GHSTFGQLG----NGHSFQGSVSDPCVCRFSLAACVKEVACGGKHTLFLLEDGQVYSCGWNGEGQLGHDHEG--TDPVQVTTLTEEHIT-HIACGQSHNLALSYQGQLYSWGSGNDGQLGHATVEHSSRIPRIIKKLNQQ--KIQQVSCGNDHCMALGDDGQLFTWGQNLHGQLGLGNGFLSQSSPQRVKS---------LEG--IPLAQVTAGGSHSFALSLSGAVFGWGNN 217
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Mouse
Match: Rcc1l (reculator of chromosome condensation 1 like [Source:MGI Symbol;Acc:MGI:2137600]) HSP 1 Score: 207.608 bits (527), Expect = 1.157e-60 Identity = 136/442 (30.77%), Postives = 225/442 (50.90%), Query Frame = 2
Query: 158 KRATKDYIRNTEIYDY-STNPPKNSYLGVFGVASTGALGIKRLINNER----IKNLHIARRVYPLYYFNDLVNFQKISIRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGL-QPHSSNINGFPILMEPSEIPLP----EKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIK-FDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKS-KVVRVACGVKYSAAITSYGSLYVWGNDI-----VSGAYNQTFPVRMPATFHAKTLYMGADHSIIV 1432
+R + + ++ Y + + V+G + +GALG+ + L RR+ P+ Y +L + I AA GYGFTL S K+ V+G G+N DSQLG + G+ ++EPS +PLP ++ K + ++CG HS+++ T+ + ++++GNN GQCGR+++++E+Y S +H ++ FD + QV CG+ + LT+ G VY CG GQ S+ ++ G + V Q++ + LAL+ DG V+GWGN+E+ + S D + P L +GKV QV+ G T CA+L+ +G + WG I+G GP + P +IP FG L + N +V ++ CG+ + AA+T+ G L+VWG +I + +Q FP R+ + G DH + +
Sbjct: 32 RREAAEAEADVPVFQYVGERAARADRVFVWGFSFSGALGVPSFVVPSSGPGPRAGLRPRRRIQPVPYRLELDH----KISSAACGYGFTLLSSKTKDVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVPLPLDRPQETKVLQ-VSCGRAHSLVL-------TDREGVFSMGNNSHGQCGRKVVEDEVYSESHKVHRMQDFDGQVVQVVCGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSTPSKLGGDLAGVTVVQVATYGDCCLALSADGGVFGWGNSEYLQLASVTDSTQVNVPRCLPF-SGVGKVKQVACGGTGCAVLNAEGHVFVWGYGILGKGPKLLETAIPEMIPPTLFG----LTEFNPEVQVSQIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEPVDVACGVDHMVTL 456
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Mouse
Match: Rpgr (retinitis pigmentosa GTPase regulator [Source:MGI Symbol;Acc:MGI:1344037]) HSP 1 Score: 85.8853 bits (211), Expect = 3.884e-17 Identity = 74/246 (30.08%), Postives = 115/246 (46.75%), Query Frame = 2
Query: 575 IACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAI-FSDEDHSCTFKPIRLNLPETIGKVIQ-VSAGSTTCAILDDKGQLHTWGMYIVG-LG-PNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAIT 1300
++CG H+ IV T N +Y G+N +GQ G + + I +K +K ++ CG T + T+ G VY G N GQL D +F QI +KQ+S NT ALTEDG+++ WG+N I D+ + C + T+GK I +S G A + G+L+T+G G LG PN+++ + R+L G +V++VACG ++ +T
Sbjct: 78 LSCGDEHTAIV-------TGNNKLYMFGSNNWGQLG--LGSKAAIIKPTCIKALKPEK-VKLAACGRNHTLVSTDTGGVYAAGGNNEGQLGLGDTDDRDTFHQIVFFTPADTIKQLSAGANTSAALTEDGKLFMWGDNSEGQIGLEDKSNVCIPHEV------TVGKPISWISCGYYHSAFVTMDGELYTFGEPENGKLGLPNELLMNHRSP---------QRVL-GIPERVIQVACGGGHTVVLT 297 HSP 2 Score: 53.9138 bits (128), Expect = 3.755e-7 Identity = 54/193 (27.98%), Postives = 90/193 (46.63%), Query Frame = 2
Query: 443 VYGCGVNHDSQLGLQPHSSNINGFPILMEPSEIPLPEKV---KGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEI---YRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAI 1003
++ G N + Q+GL+ + S + +P +V K I++I+CG HS V T + +YT G + G+ G + NE+ +R + GI + + QV CG T +LTE VY G Q+GQL +S +I I+++ + ISC N +TE G ++ +G+ H +
Sbjct: 199 LFMWGDNSEGQIGLE-------------DKSNVCIPHEVTVGKPISWISCGYYHSAFV-------TMDGELYTFGEPENGKLG---LPNELLMNHRSPQRVLGIP--ERVIQVACGGGHTVVLTEK-VVYAFGLGQFGQLGLGTFLFETSEPKIIERIKDQKICHISCGENHTALMTELGLLYTFGDGRHGKL 365
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Mouse
Match: Rpgr (retinitis pigmentosa GTPase regulator [Source:MGI Symbol;Acc:MGI:1344037]) HSP 1 Score: 85.5001 bits (210), Expect = 4.173e-17 Identity = 74/246 (30.08%), Postives = 115/246 (46.75%), Query Frame = 2
Query: 575 IACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAI-FSDEDHSCTFKPIRLNLPETIGKVIQ-VSAGSTTCAILDDKGQLHTWGMYIVG-LG-PNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAIT 1300
++CG H+ IV T N +Y G+N +GQ G + + I +K +K ++ CG T + T+ G VY G N GQL D +F QI +KQ+S NT ALTEDG+++ WG+N I D+ + C + T+GK I +S G A + G+L+T+G G LG PN+++ + R+L G +V++VACG ++ +T
Sbjct: 78 LSCGDEHTAIV-------TGNNKLYMFGSNNWGQLG--LGSKAAIIKPTCIKALKPEK-VKLAACGRNHTLVSTDTGGVYAAGGNNEGQLGLGDTDDRDTFHQIVFFTPADTIKQLSAGANTSAALTEDGKLFMWGDNSEGQIGLEDKSNVCIPHEV------TVGKPISWISCGYYHSAFVTMDGELYTFGEPENGKLGLPNELLMNHRSP---------QRVL-GIPERVIQVACGGGHTVVLT 297 HSP 2 Score: 53.9138 bits (128), Expect = 4.545e-7 Identity = 54/193 (27.98%), Postives = 90/193 (46.63%), Query Frame = 2
Query: 443 VYGCGVNHDSQLGLQPHSSNINGFPILMEPSEIPLPEKV---KGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEI---YRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAI 1003
++ G N + Q+GL+ + S + +P +V K I++I+CG HS V T + +YT G + G+ G + NE+ +R + GI + + QV CG T +LTE VY G Q+GQL +S +I I+++ + ISC N +TE G ++ +G+ H +
Sbjct: 199 LFMWGDNSEGQIGLE-------------DKSNVCIPHEVTVGKPISWISCGYYHSAFV-------TMDGELYTFGEPENGKLG---LPNELLMNHRSPQRVLGIP--ERVIQVACGGGHTVVLTEK-VVYAFGLGQFGQLGLGTFLFETSEPKIIERIKDQKICHISCGENHTALMTELGLLYTFGDGRHGKL 365
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Mouse
Match: Rpgr (retinitis pigmentosa GTPase regulator [Source:MGI Symbol;Acc:MGI:1344037]) HSP 1 Score: 85.8853 bits (211), Expect = 4.229e-17 Identity = 76/255 (29.80%), Postives = 119/255 (46.67%), Query Frame = 2
Query: 575 IACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAI-FSDEDHSCTFKPIRLNLPETIGKVIQ-VSAGSTTCAILDDKGQLHTWGMYIVG-LG-PNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWG 1327
++CG H+ IV T N +Y G+N +GQ G + + I +K +K ++ CG T + T+ G VY G N GQL D +F QI +KQ+S NT ALTEDG+++ WG+N I D+ + C + T+GK I +S G A + G+L+T+G G LG PN+++ + R+L G +V++VACG ++ +T +Y +G
Sbjct: 78 LSCGDEHTAIV-------TGNNKLYMFGSNNWGQLG--LGSKAAIIKPTCIKALKPEK-VKLAACGRNHTLVSTDTGGVYAAGGNNEGQLGLGDTDDRDTFHQIVFFTPADTIKQLSAGANTSAALTEDGKLFMWGDNSEGQIGLEDKSNVCIPHEV------TVGKPISWISCGYYHSAFVTMDGELYTFGEPENGKLGLPNELLMNHRSP---------QRVL-GIPERVIQVACGGGHTVVLTEK-VVYAFG 305 HSP 2 Score: 53.5286 bits (127), Expect = 5.598e-7 Identity = 54/193 (27.98%), Postives = 90/193 (46.63%), Query Frame = 2
Query: 443 VYGCGVNHDSQLGLQPHSSNINGFPILMEPSEIPLPEKV---KGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEI---YRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAI 1003
++ G N + Q+GL+ + S + +P +V K I++I+CG HS V T + +YT G + G+ G + NE+ +R + GI + + QV CG T +LTE VY G Q+GQL +S +I I+++ + ISC N +TE G ++ +G+ H +
Sbjct: 199 LFMWGDNSEGQIGLE-------------DKSNVCIPHEVTVGKPISWISCGYYHSAFV-------TMDGELYTFGEPENGKLG---LPNELLMNHRSPQRVLGIP--ERVIQVACGGGHTVVLTEK-VVYAFGLGQFGQLGLGTFLFETSEPKIIERIKDQKICHISCGENHTALMTELGLLYTFGDGRHGKL 365
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Mouse
Match: Rpgr (retinitis pigmentosa GTPase regulator [Source:MGI Symbol;Acc:MGI:1344037]) HSP 1 Score: 84.7297 bits (208), Expect = 1.123e-16 Identity = 76/255 (29.80%), Postives = 119/255 (46.67%), Query Frame = 2
Query: 575 IACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAI-FSDEDHSCTFKPIRLNLPETIGKVIQ-VSAGSTTCAILDDKGQLHTWGMYIVG-LG-PNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWG 1327
++CG H+ IV T N +Y G+N +GQ G + + I +K +K ++ CG T + T+ G VY G N GQL D +F QI +KQ+S NT ALTEDG+++ WG+N I D+ + C + T+GK I +S G A + G+L+T+G G LG PN+++ + R+L G +V++VACG ++ +T +Y +G
Sbjct: 78 LSCGDEHTAIV-------TGNNKLYMFGSNNWGQLG--LGSKAAIIKPTCIKALKPEK-VKLAACGRNHTLVSTDTGGVYAAGGNNEGQLGLGDTDDRDTFHQIVFFTPADTIKQLSAGANTSAALTEDGKLFMWGDNSEGQIGLEDKSNVCIPHEV------TVGKPISWISCGYYHSAFVTMDGELYTFGEPENGKLGLPNELLMNHRSP---------QRVL-GIPERVIQVACGGGHTVVLTE-KVVYAFG 305 HSP 2 Score: 51.9878 bits (123), Expect = 1.795e-6 Identity = 54/193 (27.98%), Postives = 90/193 (46.63%), Query Frame = 2
Query: 443 VYGCGVNHDSQLGLQPHSSNINGFPILMEPSEIPLPEKV---KGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEI---YRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAI 1003
++ G N + Q+GL+ S+ + +P +V K I++I+CG HS V T + +YT G + G+ G + NE+ +R + GI + + QV CG T +LTE VY G Q+GQL +S +I I+++ + ISC N +TE G ++ +G+ H +
Sbjct: 199 LFMWGDNSEGQIGLEDKSN-------------VCIPHEVTVGKPISWISCGYYHSAFV-------TMDGELYTFGEPENGKLG---LPNELLMNHRSPQRVLGIP--ERVIQVACGGGHTVVLTEK-VVYAFGLGQFGQLGLGTFLFETSEPKIIERIKDQKICHISCGENHTALMTELGLLYTFGDGRHGKL 365
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. UniProt/SwissProt
Match: sp|Q9CYF5|RCC1L_MOUSE (RCC1-like G exchanging factor-like protein OS=Mus musculus OX=10090 GN=Rcc1l PE=1 SV=1) HSP 1 Score: 207.608 bits (527), Expect = 8.096e-60 Identity = 136/442 (30.77%), Postives = 225/442 (50.90%), Query Frame = 2
Query: 158 KRATKDYIRNTEIYDY-STNPPKNSYLGVFGVASTGALGIKRLINNER----IKNLHIARRVYPLYYFNDLVNFQKISIRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGL-QPHSSNINGFPILMEPSEIPLP----EKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIK-FDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKS-KVVRVACGVKYSAAITSYGSLYVWGNDI-----VSGAYNQTFPVRMPATFHAKTLYMGADHSIIV 1432
+R + + ++ Y + + V+G + +GALG+ + L RR+ P+ Y +L + I AA GYGFTL S K+ V+G G+N DSQLG + G+ ++EPS +PLP ++ K + ++CG HS+++ T+ + ++++GNN GQCGR+++++E+Y S +H ++ FD + QV CG+ + LT+ G VY CG GQ S+ ++ G + V Q++ + LAL+ DG V+GWGN+E+ + S D + P L +GKV QV+ G T CA+L+ +G + WG I+G GP + P +IP FG L + N +V ++ CG+ + AA+T+ G L+VWG +I + +Q FP R+ + G DH + +
Sbjct: 32 RREAAEAEADVPVFQYVGERAARADRVFVWGFSFSGALGVPSFVVPSSGPGPRAGLRPRRRIQPVPYRLELDH----KISSAACGYGFTLLSSKTKDVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVPLPLDRPQETKVLQ-VSCGRAHSLVL-------TDREGVFSMGNNSHGQCGRKVVEDEVYSESHKVHRMQDFDGQVVQVVCGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSTPSKLGGDLAGVTVVQVATYGDCCLALSADGGVFGWGNSEYLQLASVTDSTQVNVPRCLPF-SGVGKVKQVACGGTGCAVLNAEGHVFVWGYGILGKGPKLLETAIPEMIPPTLFG----LTEFNPEVQVSQIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEPVDVACGVDHMVTL 456
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. UniProt/SwissProt
Match: sp|Q96I51|RCC1L_HUMAN (RCC1-like G exchanging factor-like protein OS=Homo sapiens OX=9606 GN=RCC1L PE=1 SV=2) HSP 1 Score: 204.142 bits (518), Expect = 2.070e-58 Identity = 136/413 (32.93%), Postives = 217/413 (52.54%), Query Frame = 2
Query: 239 VFGVASTGALGIKRLI----NNERIKNLHIARRVYPLYYFNDLVNFQKISIRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGL-QPHSSNINGFPILMEPSEIPLP---EKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIK-FDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKS-KVVRVACGVKYSAAITSYGSLYVWGNDI-----VSGAYNQTFPVRMPATFHAKTLYMGADHSIIV 1432
V+G + +GALG+ + RR+ P+ Y +L QKIS AA GYGFTL S K++ V+G G+N DSQLG + G+ ++EPS + LP + + ++CG HS+++ T+ + ++++GNN +GQCGR++++NEIY S +H ++ FD + QV CG+ + LT+ G VY CG GQ SS ++ G + V Q++ + LA++ DG ++GWGN+E+ + S D + P L+ +GKV Q + G T CA+L+ +G + WG I+G GPN + P +IP FG L + N +V R+ CG+ + AA+T+ G L+VWG +I + +Q FP R+ + G DH + +
Sbjct: 63 VWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELD--QKIS--SAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVSCGRAHSLVL-------TDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHF-SGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFG----LTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEPVDVACGVDHMVTL 459
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. UniProt/SwissProt
Match: sp|Q9N1T2|RPGR_CANLF (X-linked retinitis pigmentosa GTPase regulator OS=Canis lupus familiaris OX=9615 GN=RPGR PE=2 SV=1) HSP 1 Score: 97.0561 bits (240), Expect = 8.531e-20 Identity = 79/256 (30.86%), Postives = 122/256 (47.66%), Query Frame = 2
Query: 572 FIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAI-FSDEDHSCTFKPIRLNLPETIGKVIQ-VSAGSTTCAILDDKGQLHTWGMYIVG-LG-PNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWG 1327
F++CG H+ +V T N +Y G+N +GQ G + + + +K +K ++ CG T + TE G VY G N GQL D S+F I+ + +KQ+S NT ALTEDGE++ WG+N I + + C + + T+GK I +S G A + +GQL+T+G G LG PN+++ P P G KVV+VACG ++ +T ++Y +G
Sbjct: 39 FLSCGDEHTAVV-------TGNNKLYMFGSNNWGQLG--LGSKSTVSKPTCVKALKPEK-VKFAACGRNHTLVSTEGGKVYAAGGNNEGQLGLGDTEERSTFHLISFFTSQRKIKQLSAGSNTSAALTEDGELFMWGDNSEGQIGLENVTNVCVPQQV------TVGKPISWISCGYYHSAFVTTEGQLYTFGEPECGKLGLPNQLLVNHRMPQPVPGIPG----------KVVQVACGGGHTVVLTEK-AVYTFG 267
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. UniProt/SwissProt
Match: sp|Q9R0X5|RPGR_MOUSE (X-linked retinitis pigmentosa GTPase regulator OS=Mus musculus OX=10090 GN=Rpgr PE=1 SV=2) HSP 1 Score: 84.3445 bits (207), Expect = 1.073e-15 Identity = 76/255 (29.80%), Postives = 119/255 (46.67%), Query Frame = 2
Query: 575 IACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAI-FSDEDHSCTFKPIRLNLPETIGKVIQ-VSAGSTTCAILDDKGQLHTWGMYIVG-LG-PNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWG 1327
++CG H+ IV T N +Y G+N +GQ G + + I +K +K ++ CG T + T+ G VY G N GQL D +F QI +KQ+S NT ALTEDG+++ WG+N I D+ + C + T+GK I +S G A + G+L+T+G G LG PN+++ + R+L G +V++VACG ++ +T +Y +G
Sbjct: 40 LSCGDEHTAIV-------TGNNKLYMFGSNNWGQLG--LGSKAAIIKPTCIKALKPEK-VKLAACGRNHTLVSTDTGGVYAAGGNNEGQLGLGDTDDRDTFHQIVFFTPADTIKQLSAGANTSAALTEDGKLFMWGDNSEGQIGLEDKSNVCIPHEV------TVGKPISWISCGYYHSAFVTMDGELYTFGEPENGKLGLPNELLMNHRSP---------QRVL-GIPERVIQVACGGGHTVVLTE-KVVYAFG 267
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. UniProt/SwissProt
Match: sp|Q4U2R1|HERC2_MOUSE (E3 ubiquitin-protein ligase HERC2 OS=Mus musculus OX=10090 GN=Herc2 PE=1 SV=3) HSP 1 Score: 83.5741 bits (205), Expect = 2.652e-15 Identity = 82/297 (27.61%), Postives = 129/297 (43.43%), Query Frame = 2
Query: 443 VYGCGVNHDSQLGLQPHSSNIN-GFPILMEPSEIPLPEKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECG--EVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETI-----GKVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPN--KIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITS 1303
V+ G D +LG H S +N P L+E K K I IACG HS + T++ +YT G ++G+ G DN ++ + + QV CG + T LT++G V+ G +G+L C+ Q + + V QI C LALT+ G VW WG ++ + D + + P+ + K++ V+ G+ C + D GQ++ WG G N V ++PT++ L+G K + RVACG +S A T+
Sbjct: 3069 VFSWGEGDDGKLG---HFSRMNCDKPRLIEAL------KTKRIRDIACGSSHSAAL-------TSSGELYTWGLGEYGRLGHG--DNTTQLKPKMVK-VLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCN-IPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSD-------VHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQG---------LEGQK--ITRVACGSSHSVAWTT 3327 HSP 2 Score: 75.8702 bits (185), Expect = 6.786e-13 Identity = 91/367 (24.80%), Postives = 155/367 (42.23%), Query Frame = 2
Query: 245 GVASTGALGIKRLINNERIKNLHIARRVYPLYYFNDLVNFQKIS-------IRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGLQPHSSNINGFPILMEPSEIPL---PEKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECG--EVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGM--YIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITS 1303
G+AS G + + +R L RVY Y +D++ Q + ++ AA G + ++ + +GCG +LG H + L EP I + K + IACG +S + T +YT G +G+ G ++E ++ G+K K I V CG + T +TE+G V+ G YG+L C + ++ +++ V ++ C +ALT+DG+V+ WG ++ + + + + L KVI V+AGST C L + ++H+WG ++ +PT +P LD +V +ACG S A +S
Sbjct: 448 GLASLGVMQVA--CAEKRFLILSRNGRVYTQAYNSDMLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCG--DGGRLG---HGDTVP----LEEPKVISAFSGKQAGKHVVHIACGSTYSAAI-------TAEGELYTWGRGNYGRLGHGSSEDEAI--PMLVAGLKGLKVI-DVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKT-PKLIEKLQDLDVIKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGK--KVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVTKPEPTALPG---------LD--SKHIVGIACGPAQSFAWSS 779 HSP 3 Score: 72.0182 bits (175), Expect = 9.461e-12 Identity = 87/325 (26.77%), Postives = 142/325 (43.69%), Query Frame = 2
Query: 353 LVNFQKISIRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGLQPHSSNINGFPILMEPSEIP-LPEKVKGINFI--ACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECG--EVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAI-FSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVG-LGPNKI-VCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITS 1303
L + Q + I+K A G SS G VY G D +LG H + P + P + E ++GI + A G HS V T +YT G ++G+ G D+E ++ ++ + I + CG + T LT+D +V+ G YG+L C ++I VVK + C +ALT+ G V+ WG +++ + +DH +P ++ + KVI ++ GS C + G+++TWG G LG ++P ++ A L G KV RVACG ++ A ++
Sbjct: 4033 LESIQHVFIKKVAVNSGGKHCLALSSEG-EVYSWGEAEDGKLG---HGNR--------SPCDRPRVIESLRGIEVVDVAAGGAHSACV-------TAAGDLYTWGKGRYGRLGHS--DSEDQLKPKLVEALQGHRVI-DIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVK-VECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDH--VRRPRQVQGLQG-KKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAA---------LQGK--KVNRVACGSAHTLAWST 4320 HSP 4 Score: 70.0922 bits (170), Expect = 3.891e-11 Identity = 78/325 (24.00%), Postives = 131/325 (40.31%), Query Frame = 2
Query: 443 VYGCGVNHDSQLGLQPHSSNINGFPILMEPSEIPLPEKVKGIN-------FIACGLGHSVIVAEIDAIDTNNQIIYTLG---NNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVK--------QISC--RCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGK-----VIQVSAGSTTCAILDDKGQLHTWG---MYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGND 1333
VY CG + +LGL M +P+P ++ ++ + G H+ + T + +++ G + K G R D +I +K K IR + CG + LT G +Y G +YG+L D T ++ K+VK Q++C R LALT++G V+ WG+ + + C N+P+ I + V Q+ G+ L G + TWG + +G G + + ++P V+ L G K+V VA G + A+T G +Y WG++
Sbjct: 3014 VYSCGEATNGRLGLG------------MSSGTVPIPRQITALSSYVVKKVAVHSGGRHATAL-------TVDGKVFSWGEGDDGKLGHFSRMNCDK-----PRLIEALK-TKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGD---------NTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGC-------NIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSD-VHVRKPQVVEG---------LRGK--KIVHVAVGALHCLAVTDSGQVYAWGDN 3285 HSP 5 Score: 63.929 bits (154), Expect = 2.870e-9 Identity = 54/214 (25.23%), Postives = 94/214 (43.93%), Query Frame = 2
Query: 719 SVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQL---ASSDIGCCSSFIQITGGIENKVVKQISCRCN--TVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGM---YIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDG-NKSKVVRVACGVKYSAAITSYGSLYVWGND 1333
S G + K + + CG + +T +G +Y G YG+L +S D + + G++ V ++C LA+TE+G+VW WG+ ++ + C + L + VI+V GS L GQ+++WG +G G + V + P +LL+G KV+ VA G + A+T ++ WG++
Sbjct: 543 SAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSED----EAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDL--DVIKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHV-RYP------------KLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSN 737 HSP 6 Score: 55.4546 bits (132), Expect = 1.167e-6 Identity = 59/242 (24.38%), Postives = 99/242 (40.91%), Query Frame = 2
Query: 644 IYTLG---NNKFGQCGRQIIDN----EIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCN--TVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWG---MYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGND 1333
+Y+ G + K G R D E RG V+ V G + +T G +Y G +YG+L SD ++ ++ V I+C L LT+D VW WG+ ++ + C P++++ +G V++V GS L G ++TWG + +G G + V ++P + L G K V+ +A G + T G +Y WG++
Sbjct: 4062 VYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVV----------DVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSD-SEDQLKPKLVEALQGHRVIDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKV-PMKIDSLTGLG-VVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHV-RRPRQVQG---------LQGKK--VIAIATGSLHCVCCTEDGEVYTWGDN 4278 HSP 7 Score: 54.6842 bits (130), Expect = 2.374e-6 Identity = 69/275 (25.09%), Postives = 109/275 (39.64%), Query Frame = 2
Query: 644 IYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRC--NTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVG----------LGPNKIVCKQP-TVIPAPFFGGGSRLL------------DGNKSK----------------------VVRVACGVKYSAAITSYGSLYVWG 1327
IY G+N GQ G I+ + + + +P+ Q+ GE T F +T DG +Y G G+L S+ + I++ +K+++ LAL+ +GEV+ WG E + C +P + I +V+ V+AG A + G L+TWG G L P + Q VI G ++ L DG+ K VV+V CG ++S A+T G++Y WG
Sbjct: 3956 IYGWGHNHRGQLGG--IEGAKVKVPTPCEALATLRPV-QLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVST-PTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCD-RPRVIESLRGI-EVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVIDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWG 4224
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. TrEMBL
Match: T1G3K3 (Uncharacterized protein OS=Helobdella robusta OX=6412 GN=20215651 PE=4 SV=1) HSP 1 Score: 248.44 bits (633), Expect = 3.807e-73 Identity = 142/408 (34.80%), Postives = 230/408 (56.37%), Query Frame = 2
Query: 242 FGVASTGALGIKRLINNERIKNLHIARRVYPLYYFNDLVNFQKISIRKAATGYGFTLFSGK--SSIGWHVYGCGVNHDSQLGLQPHSSNING-FPILMEPSEIPLPEKVKG--INFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAI-FSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGNDIVS----GAYN-QTFPVRMPATFHAKTLYMGADHSIIV 1432
+G ASTGALG+K L+ E+ + R+V +++ +K+ ++ GYGFT+F+ + S+ HVYG G+N DSQ+G + +L+EPSEI LP + + I +ACG H+VIV T+ + ++TLGNN GQCGR+II++EI+RGS +++ I F + I+QV CG+ T +LT+DG ++ CG + GQ C +F ++ G ++ + + Q+S + +TVLA++E G+++GWGNNE++ + D + P + L +G V + +TCAIL+ KG ++TWG I+G GP P VIP FG + V + CG+ + A+T G LY WG + ++ G N Q FP++ K ++ G DH++++
Sbjct: 40 WGSASTGALGVKTLVRPEKHQK---TRKVQLTPLKIEIMAKRKLKVKAMGCGYGFTVFACEDGSTGQMHVYGTGLNTDSQIGYHEYPRRSGRVLELLIEPSEIQLPLQNRSTRITHVACGRAHTVIV-------TDGEGVFTLGNNSLGQCGRKIIESEIFRGSQLVNRIDFKEKIKQVVCGQDHTLLLTDDGRLFACGLSTDGQTGQGHYECVENFEEVVGDVKGEKIVQVSSKADTVLAVSEKGDLFGWGNNEYDQLEIVAPDETQLHTPRHVRLRPDVGPVKKTCTAGSTCAILNRKGLVYTWGYGILGRGPTVDRSAVPHVIPPILFGNTD--YKTGDAAVTDLQCGLHFFTALTCSGDLYTWGRNRLACLGLGHVNDQYFPLKTHIPAEVKQVHCGVDHAVVL 435
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. TrEMBL
Match: A0A1W4WGP9 (Williams-Beuren syndrome chromosomal region 16 protein homolog OS=Agrilus planipennis OX=224129 GN=LOC108733084 PE=4 SV=1) HSP 1 Score: 236.884 bits (603), Expect = 1.231e-68 Identity = 145/452 (32.08%), Postives = 232/452 (51.33%), Query Frame = 2
Query: 122 KNFFNQIRSFGVKR---ATKDYIRNTEIYDYSTNPPKNSYLGVFGVASTGALGIKRLINNERIKNLHIARRVYPLYYFNDLVNFQKISIRKAATGYGFTLFS-GKSSIGWHVYGCGVNHDSQLGLQPHSSNINGFPILMEPSEI--PLPEKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIK-FDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGNDI-----VSGAYNQTFPVRMPATFHAKTLYMGADHSIIVGAP 1441
K FFNQIR + VKR + + ++ Y + + + V+G TGAL + + E+ ++ P+ Y L + + A G+GF++FS ++ +YG G+N DSQ+G N I+ P I PL EK IN IA G H++++ ++ ++T GNN +GQCGR II +E Y S +H I D I+ VECG+ + ILTE G VY CG GQ S F ++ G I N+ + ++S R + VLA+ + GEV+GWGN E+ + + D + + +GK++ ++AG + C IL++ GQ+ +WG ++G GP K+P ++P FG D SKV+++ G+ ++AAI++YG+LY+WG + + +Q FP R+ + K + G DHSI + P
Sbjct: 5 KQFFNQIRGYAVKRKYPVNPEDAKKLPVFGYGISKASYNRIFVWGCRETGALAVPQKKEEEKF------HKISPIKYPKRLFFAENHEVTNVACGFGFSIFSVNPNNDNSRLYGTGINSDSQIGYHAIREN-KPLEIIFSPVAIHLPLKEKKTRINKIAAGRAHTLVLT--------SEGLFTFGNNAYGQCGRMIITDEDYSNSHYVHKISNVDDTIKDVECGQDHSLILTESGQVYSCGWGADGQTGLGHFNSESRFTRVLGDIANENIVKVSGRSDFVLAINDKGEVFGWGNTEYAQLDTPNDLQQVCNATFIEKCKGLGKIVDIAAGGSFCLILNEDGQVFSWGYGLLGAGPKVQYSKKPVLLPEILFGKNEFQTD---SKVIKIKAGIGHAAAISNYGNLYMWGRNRSGCLGMGHDKDQPFPFRVSVSGLVKDVSCGFDHSIALCKP 438
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. TrEMBL
Match: A0A0L8GIM0 (Uncharacterized protein OS=Octopus bimaculoides OX=37653 GN=OCBIM_22033421mg PE=4 SV=1) HSP 1 Score: 237.269 bits (604), Expect = 1.742e-68 Identity = 152/438 (34.70%), Postives = 230/438 (52.51%), Query Frame = 2
Query: 158 KRATKDYIRNTEIYDYSTNPPK--NSYLGVFGVASTGALGIKRLINNERIKNLHIA--RRVYPLYYFNDLVNFQKISIRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGLQPHSSNINGF-PILMEPS--EIPL--PEKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIK-FDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGNDI-----VSGAYNQTFPVRMPATFHAKTLYMGADHSI 1426
KR K + Y+ N L +G ++TGALGIK + +K H++ R L +F++ Q + + A GYGFTLF + G G+N DSQ+G + + F ++EP+ EIPL P K K I +A G H++I+ T+ + +++LGNN FGQCGR I++ E YRGSS I I+ I++V CG+ TF LT+ G VY CG + GQ S Q+ G IE +KQI+C + VLAL+++G ++GWGN+E+N + DH+ P L ++GK+ QV++G + C L+ G++ TWG I+G GP PT +P P FG LD K+ VV + CG+ + AA+T++G LY WG + + +Q FP+R+ ++ G DH +
Sbjct: 35 KRIAKQQAIEETVVQYTAEDVSHLNERLYAWGFSATGALGIKSYLR-PGVKQTHLSFMHRPARLKFFDE----QHLKVGHVACGYGFTLFQSSLQGSSVLLGTGINTDSQIGCYQMQKDSDRFLDYIIEPTNIEIPLLHPTKTKIIG-MAGGRAHAIIL-------TDQEGVFSLGNNSFGQCGRPIVETEKYRGSSTITKIRHLPDNIKEVVCGQDHTFFLTQSGEVYSCGLSSDGQTGLGHYKNVSQATQVKGDIEGVNIKQIACSGDCVLALSDEGNLFGWGNSEYNQLALITDHTQVHTPKHFKLSASLGKITQVASGGSICGFLNASGEVFTWGFGILGRGPKVQSSTVPTKLPTPLFGANE--LDPAKT-VVSLKCGIYHFAALTNHGDLYTWGKNKQGYLGLGDRNDQFFPLRVSMPVEVINVWCGVDHMV 456
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. TrEMBL
Match: B5X3R9 (Williams-Beuren syndrome chromosomal region 16 protein homolog OS=Salmo salar OX=8030 GN=WBS16 PE=2 SV=1) HSP 1 Score: 227.254 bits (578), Expect = 7.563e-65 Identity = 141/435 (32.41%), Postives = 230/435 (52.87%), Query Frame = 2
Query: 161 RATKDYIRNTEIYDYSTNPPK-NSYLGVFGVASTGALGIKRLINNERIKNLHIARRVYPLYYFNDLVNFQKISIRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGLQ-PHSSNINGFPILMEPSEIPLP---EKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIK-FDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGNDI-----VSGAYNQTFPVRMPATFHAKTLYMGADHSIIV 1432
R +++ ++ Y K N + V+G + TGALGI + + + R Y L + L Q+IS AA GYGFTL S + V+G G+N DSQLG Q + ++EPS +PLP + + +ACG HS+++ T+++ +++LGNN +GQCGR+++++E+Y S +IH ++ FD P+ QV CG+ + LTE G VY CG GQ C+ + + G + V+Q++ + +A+++DG+++GWGN+E+ + S + + P RL E +GKV QV+ G T AIL+++G++ WG I+G GPN + P ++P FG R V R+ CG+ + AA+T G L+VWG ++ + +Q FP R+ H + G DH + +
Sbjct: 28 RRSRELKDEGPVFQYVGKQRKPNHKVFVWGFSYTGALGIPSFVIPDSGRK---KPRKYQLTPYR-LETEQQIS--SAACGYGFTLLSSSTKDLTKVWGMGLNRDSQLGFQRTQQDRHKSYDYVLEPSPVPLPLARPQQTRVVQVACGRAHSLVL-------TDSEGVFSLGNNAYGQCGRKMVEDEVYSASHIIHKMEGFDSPVTQVVCGQDHSLFLTETGKVYACGWGADGQTGLGHHNMCARPVAVGGDLAGVRVQQVTTYGDCSMAVSQDGQLYGWGNSEYLQLSSVTEATQINSP-RLLPFERVGKVTQVACGGTQVAILNERGEVFVWGYGILGKGPNLSESQTPELVPPALFG---RSEFNPAVTVSRIHCGLNHFAAVTDRGELFVWGKNVRGCLGIGKKEDQYFPWRVTVPGHVVDVACGVDHMVAL 445
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. TrEMBL
Match: V5GWG5 (Williams-Beuren syndrome chromosomal region protein (Fragment) OS=Anoplophora glabripennis OX=217634 GN=WBS16 PE=4 SV=1) HSP 1 Score: 227.639 bits (579), Expect = 7.683e-65 Identity = 140/437 (32.04%), Postives = 229/437 (52.40%), Query Frame = 2
Query: 176 YIRNTEIYDYSTNPPKNSYLGVFGVASTGALGIKRLINNER---IKNLHIARRVYPLYYFNDLVNFQKISIRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGLQPHSSNINGFPILMEPSEIPLP----EKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGI-KFD-KPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVV-RVACGVKYSAAITSYGSLYVWGNDI-----VSGAYNQTFPVRMPATFHAKTLYMGADHSIIVGAP 1441
++ ++ Y+ + + +G TGALG+ + NN+ I+ L RR+ ++ + AA G+GFT++ S +YG G+N DSQ+G I+ P IPLP EK K I +A G HSV++ + + I+TLGNN +GQCGR++I NE Y S+ IH I K + K I +ECG+ + LTEDG+VY CG GQ + F ++ G IEN+ + +++C+ + LAL + G+V+GWGN E+N I P +++ + IGK+ +++ T C +++++G +++WG ++G+GPN K P IP FG L D + +V +V CG+ Y+ A+T+ G L+ WG + + G +Q FP+++ H ++ GADHS+ + P
Sbjct: 57 HVEKLPVFQYTVSKKNYRRVFAWGNLETGALGVPYVENNKNKDIIRCLSFPRRI---------TFGEQFEVVSAACGFGFTIYGVNSDTNIKIYGTGINTDSQIGYH-EVRQYKPLGIIFRPQPIPLPFLNPEKTK-ILKLAAGRAHSVVLTD--------EGIFTLGNNSYGQCGRKVIPNEDYSMSNYIHHISKLEGKNIVDIECGQDHSLALTEDGNVYSCGWGADGQTGLNHFDNVEQFTRVKGDIENEKIVKLACKADFTLALNDKGDVFGWGNTEYNQITLPGGDQQLSVPSYIDMLKKIGKITSIASSGTLCIVVNEQGHVYSWGYGLLGVGPNIQQSKLPIKIPETLFG----LNDFQPNNIVQKVVCGLNYAVAVTNGGDLFAWGRNKHGCLGLGGDKDQYFPLKVSLGGHVDEIFCGADHSVTICKP 470
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Cavefish
Match: rcc1l (RCC1 like [Source:ZFIN;Acc:ZDB-GENE-060526-370]) HSP 1 Score: 188.734 bits (478), Expect = 8.987e-54 Identity = 135/409 (33.01%), Postives = 213/409 (52.08%), Query Frame = 2
Query: 239 VFGVASTGALGIKRLINNERIKNLHIARRVYPLYYFNDLVNFQKISIRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGLQ-PHSSNINGFPILMEPSEIPLP---EKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIK-FDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQ-LASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGNDI-----VSGAYNQTFPVRMPATFHAKTLYMGADHSIIV 1432
V+G + TGALG+ + + + R Y L + L QKIS AA GYGFTL + + V+G G+N DSQLG Q + ++EPS + LP + + ++CG HS+++ + + +++GNN +GQCGR+I++NE+Y GS ++H I+ F+ + QV CG+ + LTE GSVY CG GQ L D + + G + ++Q+S + LA++ +G+++GWGN+E+ + S + + P L L + +GKV Q + G T AIL++ G++ WG I+G GPN + P +PA FG R KV + CG+ AAIT G L+VWG ++ + +Q FP R+ H + G DH + +
Sbjct: 56 VWGFSCTGALGVPSFVVPDSGRK---KLRKYQLTPYR-LDTEQKIS--SAACGYGFTLLASNTKDLTKVWGMGLNKDSQLGFQRTQHYRDKSYDYVLEPSPVSLPLVNPQETRVLQVSCGRAHSLVLTDSEG--------FSIGNNVYGQCGRKIVENEVY-GSHLVHKIEGFESRVVQVACGQDHSLFLTETGSVYACGWGADGQTLGHHDKTAIP--VLVGGDLAGVKIQQVSTYGDCSLAVSTEGQLFGWGNSEYLQLASVTETTQISSPRLLPL-DGVGKVTQAACGGTQVAILNE-GEMFVWGYGILGKGPNLSESEMPEKVPATLFG---RSEFSPTVKVSHIRCGLTNFAAITR-GELFVWGKNVRGCLGIGKRDDQYFPWRVTVPGHVVDVACGVDHMVAL 441
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Cavefish
Match: RPGR (retinitis pigmentosa GTPase regulator [Source:HGNC Symbol;Acc:HGNC:10295]) HSP 1 Score: 75.485 bits (184), Expect = 5.852e-14 Identity = 67/257 (26.07%), Postives = 115/257 (44.75%), Query Frame = 2
Query: 572 FIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYI---VGLGPNKIV-CKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGN 1330
I+CG HS V E + ++ G+N GQ G + + +K ++ +R CG T + T G ++ G N GQL +SF Q+ + +KQ+S CNT ALTEDG ++ WG+N + ++ F P L + + V +S G A++ D G ++T+G +GL +++ +QP + G+ V++V+CG ++ A+T LY +G+
Sbjct: 67 LISCGHSHSAFVTE-------HGRLFVFGSNSSGQLG--LESKGPITKPVCVKALKHER-VRFTACGTNHTLVSTSRGEIFAAGRNSEGQLGLGHCEERTSFQQLHPFCDGAPLKQLSAGCNTSAALTEDGRLFMWGDNSVGQLGLGSENLVLF-PKLLKVDRS---VTGISCGLNHSALITDIGDVYTFGEAADGRLGLSADQLANHRQPQRV-------------GSLEGVLQVSCGGTHTLALTE-NELYAFGH 295
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Cavefish
Match: rcbtb1 (regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 [Source:ZFIN;Acc:ZDB-GENE-030131-7951]) HSP 1 Score: 74.3294 bits (181), Expect = 1.052e-13 Identity = 71/271 (26.20%), Postives = 122/271 (45.02%), Query Frame = 2
Query: 545 LPEKVKGIN-----FIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVG-LGP-NKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVAC--GVKYSAAITSYGSLYVWGN 1330
+P K+ G++ ++ G G V++A T +Y G+N + Q G + + ++ +K + +V CG + LT DG V+ G N GQ+ S + +++ ++NK V I+C + +A++++GEV+GWG N N ++ P RL + + V+Q+++G L D+G L+ WG G LG NK P + A K ++V +A SAA T G +Y+WG
Sbjct: 124 VPRKLDGLSGKKVVSLSYGSGPHVLLA------TEEGDMYAWGHNGYSQLGNGTTNQGVC--PVLVSTNLQNKRVIEVACGSHHSLALTHDGEVFAWGYNNCGQVGSGSTANQPTPRKVSNCLQNKAVVSIACGQTSSMAVSDNGEVYGWGYNG-NGQLGLGNNGNQLTPCRLAALQGLC-VLQIASGYAHSLALTDEGLLYAWGANTYGQLGTGNKSNQLSPVQVMA------------EKERIVEIAACHSTHTSAAKTQSGQVYMWGQ 372
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Cavefish
Match: herc2 (HECT and RLD domain containing E3 ubiquitin protein ligase 2 [Source:ZFIN;Acc:ZDB-GENE-070718-6]) HSP 1 Score: 74.3294 bits (181), Expect = 1.888e-13 Identity = 80/297 (26.94%), Postives = 128/297 (43.10%), Query Frame = 2
Query: 443 VYGCGVNHDSQLGLQPHSSNIN-GFPILMEPSEIPLPEKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECG--EVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETI-----GKVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPN--KIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITS 1303
V+ G D +LG H S +N P L+E K K I IACG HS + T++ +Y+ G ++G+ G DN ++ + + QV CG + T LT++G V+ G +G+L C+ Q + + V QI C LALT+ G VW WG ++ + D + + P+ + K++ V+ G+ C + + GQ+ WG G N V ++PT++ L+G K + RVACG +S A T+
Sbjct: 3061 VFSWGEGDDGKLG---HFSRMNCDKPRLIEAL------KTKRIRDIACGSSHSAAI-------TSSGELYSWGLGEYGRLGHG--DNTTQLRPKLVK-VLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCN-IPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGTD-------VHVRKPQMVEGLRGKKIVHVAVGALHCLAVTETGQVFAWGDNDHGQQGNGTTTVNRKPTLVQG---------LEGQK--ITRVACGSSHSVAWTT 3319 HSP 2 Score: 69.707 bits (169), Expect = 4.970e-12 Identity = 64/255 (25.10%), Postives = 114/255 (44.71%), Query Frame = 2
Query: 560 KGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECG--EVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWG-----MYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITS 1303
K + IACG +S + T + ++T G +G+ G +++ ++ +K K I V CG + T +TE+G V+ G YG+L C S ++ +++ + ++ C +ALT+DG+V+ WG ++ + D + + +L KV+ ++ GST C L + G++H+WG + L NK KQP +P N +V ++CG S A +S
Sbjct: 550 KHVVHIACGSTYSAAI-------TADGELFTWGRGNYGRLGHGSSEDQTT--PMLVTALKGLKVI-DVACGSGDAQTLSVTENGQVWSWGDGDYGKLGRGGSDGCKS-PKLVEKLQDLDIVKVCCGSQFSVALTKDGQVYTWGKGDNQRLGHGTDEHVRYPKLLDSLQGK--KVVDIAVGSTHCLALTEDGEVHSWGSNDKLQHFDTLFSNK---KQPKALPGL-----------NSKHIVGISCGPGQSFAWSS 777 HSP 3 Score: 67.781 bits (164), Expect = 2.508e-11 Identity = 87/325 (26.77%), Postives = 142/325 (43.69%), Query Frame = 2
Query: 353 LVNFQKISIRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGLQPHSSNINGFPILMEPSEIP-LPEKVKGINF--IACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECG--EVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAI-FSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVG-LGPNKI-VCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITS 1303
L + Q + IRK A G SS G VY G D +LG H + P + P + E ++G+ IA G HS + T + +YT G ++G+ G D+E ++ ++ + I V CG + T LT+D V+ G YG+L C ++I VVK + C +ALT+ G V+ WG +++ + +DH +P ++ + KVI ++ GS C + G+++TWG G LG ++P ++ A L G K+ RVACG ++ A ++
Sbjct: 4026 LESIQHVFIRKVAVNSGGKHCLALSSEG-EVYSWGEAEDGKLG---HGNR--------SPCDRPRVIESLRGVEVVDIAAGGAHSACI-------TASGELYTWGKGRYGRLGHG--DSEDQLKPKLVDALQGHRVI-DVACGSGDAQTLCLTDDDMVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVK-VECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDH--VRRPRQVQGLQG-KKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAA---------LQGK--KINRVACGSAHTLAWST 4313 HSP 4 Score: 62.7734 bits (151), Expect = 8.721e-10 Identity = 77/324 (23.77%), Postives = 130/324 (40.12%), Query Frame = 2
Query: 443 VYGCGVNHDSQLGLQPHSSNINGFPILMEPSEIPLPEKVKGI-NFIACGL-----GHSVIVAEIDAIDTNNQIIYTLG---NNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVK--------QISC--RCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGK-----VIQVSAGSTTCAILDDKGQLHTWGM---YIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGND 1333
VY CG + +LGL S I P+P +V + N++ + G + +D +++ G + K G R D +I +K K IR + CG + +T G +Y G +YG+L D T + K+VK Q++C R LALT++G V+ WG+ + + C N+P+ I + V Q+ G+ L G + TWG + +G G + + ++P ++ L G K+V VA G + A+T G ++ WG++
Sbjct: 3006 VYACGEATNGRLGLGLSSGTI------------PIPRQVSALSNYVVKKVAVHSGGRHAMALTVDGK------VFSWGEGDDGKLGHFSRMNCDK-----PRLIEALK-TKRIRDIACGSSHSAAITSSGELYSWGLGEYGRLGHGD---------NTTQLRPKLVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGC-------NIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGTD-VHVRKPQMVEG---------LRGK--KIVHVAVGALHCLAVTETGQVFAWGDN 3277 HSP 5 Score: 59.6918 bits (143), Expect = 8.038e-9 Identity = 56/215 (26.05%), Postives = 96/215 (44.65%), Query Frame = 2
Query: 719 SVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIEN--KVVKQISCRCNT----VLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGM---YIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNK-SKVVRVACGVKYSAAITSYGSLYVWGND 1333
+ G + K + + CG + +T DG ++ G YG+L G SS Q T + K +K I C + L++TE+G+VW WG+ ++ + C + L + +++V GS L GQ++TWG +G G ++ V + P +LLD + KVV +A G + A+T G ++ WG++
Sbjct: 541 AAFSGKQVGKHVVHIACGSTYSAAITADGELFTWGRGNYGRL-----GHGSSEDQTTPMLVTALKGLKVIDVACGSGDAQTLSVTENGQVWSWGDGDYGKLGRGGSDGCKSPKLVEKLQDL--DIVKVCCGSQFSVALTKDGQVYTWGKGDNQRLGHGTDEHV-RYP------------KLLDSLQGKKVVDIAVGSTHCLALTEDGEVHSWGSN 735 HSP 6 Score: 53.9138 bits (128), Expect = 4.726e-7 Identity = 58/213 (27.23%), Postives = 95/213 (44.60%), Query Frame = 2
Query: 722 VIHGIKFDKPIRQVECGEVTTFI-LTEDGSVYGCGSNQYGQLASSDIGCCSSFIQI---TGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIF--SDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILD--DKGQLHTWGMYIVG-LGPN-KIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGN 1330
++HG+ K ++ E ++ L+ +G V+ G G+L D I +G K V I+C A+T DGE++ WG + + S ED + P+ + + + KVI V+ GS L + GQ+ +WG G LG CK P ++ +L D + +V+V CG ++S A+T G +Y WG
Sbjct: 485 LVHGLSSRKIVKLAAHPEGQHYLALSANGEVFSWGCGDGGRLGHGDTTYLEEPTMIAAFSGKQVGKHVVHIACGSTYSAAITADGELFTWGRGNYGRLGHGSSEDQTT---PMLVTALKGL-KVIDVACGSGDAQTLSVTENGQVWSWGDGDYGKLGRGGSDGCKSPKLV--------EKLQDLD---IVKVCCGSQFSVALTKDGQVYTWGK 682 HSP 7 Score: 51.9878 bits (123), Expect = 1.524e-6 Identity = 52/192 (27.08%), Postives = 81/192 (42.19%), Query Frame = 2
Query: 803 GSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVK--------------QISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVG-LGP-NKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGN 1330
G++YG G N GQL GGIE VK Q+ T+ A+T DG+++ G + S + + ++ + + V++G C L +G++++WG G LG N+ C +P VI + L G +VV +A G +SA IT+ G LY WG
Sbjct: 3947 GTIYGWGHNHRGQL---------------GGIEGAKVKVPTPTEALATLRPVQLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIRKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIES---------LRG--VEVVDIAAGGAHSACITASGELYTWGK 4112 HSP 8 Score: 51.9878 bits (123), Expect = 1.646e-6 Identity = 67/278 (24.10%), Postives = 111/278 (39.93%), Query Frame = 2
Query: 644 IYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRC--NTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIG--KVIQVSAGSTTCAILDDKGQLHTWGMYIVG----------LGPNKIVCKQ-PTVIPAPFFGGGSRLL------------DGNKSK----------------------VVRVACGVKYSAAITSYGSLYVWGN 1330
IY G+N GQ G I+ + + + +P+ Q+ GE T F +T DG +Y G G+L S+ + I++ +++++ LAL+ +GEV+ WG E + C R + E++ +V+ ++AG A + G+L+TWG G L P + Q VI G ++ L DG+ K VV+V CG ++S A+T G++Y WG
Sbjct: 3949 IYGWGHNHRGQLGG--IEGAKVKVPTPTEALATLRPV-QLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPT-LLESIQHVFIRKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCD----RPRVIESLRGVEVVDIAAGGAHSACITASGELYTWGKGRYGRLGHGDSEDQLKPKLVDALQGHRVIDVACGSGDAQTLCLTDDDMVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGK 4218 HSP 9 Score: 51.2174 bits (121), Expect = 3.098e-6 Identity = 48/164 (29.27%), Postives = 80/164 (48.78%), Query Frame = 2
Query: 557 VKGINFI--ACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVY--GCGSNQ-YGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEH----NAIFSDEDH 1021
+KG+ I ACG G A+ ++ N Q+ ++ G+ +G+ GR D + ++ ++ D I +V CG + LT+DG VY G G NQ G + + ++ ++ K V I+ LALTEDGEV WG+N+ + +FS++
Sbjct: 599 LKGLKVIDVACGSGD----AQTLSVTENGQV-WSWGDGDYGKLGRGGSDG--CKSPKLVEKLQ-DLDIVKVCCGSQFSVALTKDGQVYTWGKGDNQRLGHGTDEHV----RYPKLLDSLQGKKVVDIAVGSTHCLALTEDGEVHSWGSNDKLQHFDTLFSNKKQ 750 HSP 10 Score: 49.6766 bits (117), Expect = 8.485e-6 Identity = 61/269 (22.68%), Postives = 106/269 (39.41%), Query Frame = 2
Query: 644 IYTLG---NNKFGQCGRQIIDN----EIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCN--TVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGM---YIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGND----IVSGAYNQTFPVRMPATFHAKTL 1402
+Y+ G + K G R D E RG V+ + G + +T G +Y G +YG+L D ++ ++ V ++C L LT+D VW WG+ ++ + C P++++ +G V++V GS L G ++TWG + +G G + V ++P + L G K V+ +A G + T G +Y WG++ + G N R+ A K +
Sbjct: 4055 VYSWGEAEDGKLGHGNRSPCDRPRVIESLRGVEVV----------DIAAGGAHSACITASGELYTWGKGRYGRLGHGD-SEDQLKPKLVDALQGHRVIDVACGSGDAQTLCLTDDDMVWSWGDGDYGKLGRGGSDGCKV-PMKIDSLTGLG-VVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHV-RRPRQVQG---------LQGKK--VIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKI 4298
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Cavefish
Match: NEK9 (NIMA related kinase 9 [Source:NCBI gene;Acc:103037873]) HSP 1 Score: 72.4034 bits (176), Expect = 5.884e-13 Identity = 75/288 (26.04%), Postives = 123/288 (42.71%), Query Frame = 2
Query: 548 PEKV-----KGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFD----KPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLA--SSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAI------------FSDEDHSCTFKPIRLNLPETIG--KVIQVSAGSTTCAILDDKGQLHTWGMYIVG-LGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVV-RVACGVKYSAAITSYGSLYVWGN 1330
P KV K I +ACG A+ A T+ +Y G++ +G G ++NE+ G V+ + + +P+RQV CG+ +LT G +Y G ++G+L D +++ G + + C + LTE G+V GNN+ N + F + + L L + + K+ ++ G T A +D++G+L T+G G LG Q I FGG KVV +V+CG ++ A T ++ WGN
Sbjct: 404 PRKVERLQGKAIRQVACG-------ADFTACVTDEDQMYMFGSDYYGCIG---VENEM--GMEVLEPVLLEFFEERPVRQVSCGDNHVVVLTHSGDIYSWGCGEHGRLGLDCEDDFASPMLVEVPKGAS---IDSVYCGSDGTFFLTESGKVLACGNNDLNKLGLNQGITGIKNHFREGSQEIPYTTT-LTLVKQLARFKIQIIAPGKTHTAAIDERGRLMTFGCNKYGQLGVKDFKRHQGVQILLGPFGG----------KVVSKVSCGDGFTIAATEDNQIFAWGN 665 HSP 2 Score: 53.9138 bits (128), Expect = 3.847e-7 Identity = 66/253 (26.09%), Postives = 109/253 (43.08%), Query Frame = 2
Query: 620 AIDTNNQIIYTL-----GNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQL-ASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSD-EDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKS----------KVVRVACGVKYSAAITSYGSLYVWG 1327
A+ T + +YT G GQ G D YR + ++ K IRQV CG T +T++ +Y GS+ YG + +++G + E + V+Q+SC N V+ LT G+++ WG EH + D ED + P+ + +P+ + V GS L + G++ G + NK+ Q F GS+ + + K+ +A G ++AAI G L +G
Sbjct: 369 AVVTVEKELYTWASVQGGAKMVGQLGHG--DQASYRQPRKVERLQ-GKAIRQVACGADFTACVTDEDQMYMFGSDYYGCIGVENEMGMEVLEPVLLEFFEERPVRQVSCGDNHVVVLTHSGDIYSWGCGEHGRLGLDCEDDFAS--PMLVEVPKG-ASIDSVYCGSDGTFFLTESGKVLACGNNDL----NKLGLNQGITGIKNHFREGSQEIPYTTTLTLVKQLARFKIQIIAPGKTHTAAIDERGRLMTFG 611
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Sea Lamprey
Match: rcc1l (RCC1 like [Source:ZFIN;Acc:ZDB-GENE-060526-370]) HSP 1 Score: 203.756 bits (517), Expect = 2.706e-60 Identity = 128/413 (30.99%), Postives = 215/413 (52.06%), Query Frame = 2
Query: 239 VFGVASTGALGIKRLINNERIKNLHIARRVYPLYYFNDLVNFQKISIRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGL-QPHSSNINGFPILMEPSEIPLP---EKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIK-FDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETI-----GKVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGNDI-----VSGAYNQTFPVRMPATFHAKTLYMGADHSIIV 1432
V+G TGALGI ++ + H R++ + + L KI AA GYGFTL + K+ ++G G+N DSQ+G + S + ++EPS +PLP + + +ACG HS+++ + N ++++GNN +GQCGR II++E+Y+GS +IH I+ + + +V CG+ + TE G +Y CG GQ CS+ ++ G + + V Q++ + LA++E GE++GWGN+E+ + + D +++N+P+ I GKV +AG T C IL+++G++ WG I+G GP + P IP FG R +V + CG+ + AA+ + G L+ WG ++ + +Q FP R+ + G DHS+ +
Sbjct: 31 VWGFTFTGALGIPNFVSP--VSKRHKPRKIQ--FTPHRLETDDKII--SAACGYGFTLLASKTKDLTKLWGAGLNIDSQIGFHRSRSDRTKSYDYILEPSPVPLPLVEHQQTRVLQVACGRAHSLVLTD------NEGAVFSMGNNAYGQCGRVIIEDEVYKGSRLIHKIEGIEGKVVEVVCGQDHSLFRTEKGELYACGWGADGQTGLGSYEMCSTPKRLGGDLSGEPVAQVASYGDFCLAVSESGELFGWGNSEYRQLAAITD------AVQINVPKHIPLKNVGKVKMAAAGGTICGILNEEGEVFVWGYGILGKGPRLSETETPEQIPPSLFG---RTEFDPDIRVKTLRCGLHHFAAVNTRGELFSWGKNMRGCLGIGRPDDQYFPWRVTVAGEVVDVACGVDHSVAL 422
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001275.1 (pep scaffold:Pmarinus_7.0:GL476529:184068:212443:-1 gene:ENSPMAG00000001140.1 transcript:ENSPMAT00000001275.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 68.5514 bits (166), Expect = 1.992e-12 Identity = 82/344 (23.84%), Postives = 142/344 (41.28%), Query Frame = 2
Query: 443 VYGCGVNHDSQLGLQPHSSNINGFPILMEPSEIPLPEKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGE-VWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGM-YIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGNDIVS--GAYNQTFPVRMPAT------FHAKTLYMGADHSIIVGAPP 1444
V CG +LGL ++ + EP VK I+ GH++ V T +++ G+ +G+ G + Y +I G K + V G + +TEDG +Y G +G+L D + + I N V Q++C + +A+++DG VW +G + N D + +KP + + + + +V AGS + L GQL+ WG +G G ++ +P +I D +++V ++CG + A+T +Y WGN+ + G + T PV P + + G HS+ A P
Sbjct: 431 VRACGKGSYGRLGLGDSNNQSTLKKLTFEPQR-----AVKKISSSRGSDGHTLAV-------TMEGEVFSWGDGDYGKLGHGNSSTQKY--PKLIQGPLQGKVVVCVSAGYRHSASVTEDGELYTWGEGDFGRLGHGDSNS-RNIPTLVKDISN--VGQVACGSSHTIAVSQDGRIVWSFGGGD-NGKLGHGDTNRVYKPKVIEALQGM-FIRKVCAGSQSSLALTSTGQLYAWGCGACLGCGSSEATALRPKLIE-----------DLACTRIVDISCGDSHCLALTHDNEVYAWGNNSMGQCGQGHSTSPVTKPKKVMGMDGISVQQISAGTSHSLAWTALP 744 HSP 2 Score: 64.6994 bits (156), Expect = 3.758e-11 Identity = 70/236 (29.66%), Postives = 104/236 (44.07%), Query Frame = 2
Query: 755 RQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNT--VLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQ-VSAGSTTCAILDDKGQLHTWGMYIVG-LG---------PN---------KIVCKQPTVIPAP-------FFGGGS--RLLDGNKSKV-------------VRVAC-GVKYSAAITSYGSLYVWG 1327
+ +E G+ TF++ DGSV CG YG+L D S+ ++T + V K S R + LA+T +GEV+ WG+ ++ + +S T K +L GKV+ VSAG A + + G+L+TWG G LG P ++ C I FGGG +L G+ ++V +R C G + S A+TS G LY WG
Sbjct: 413 QTIEAGQYCTFVIAVDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPQRAVKKISSSRGSDGHTLAVTMEGEVFSWGDGDYGKL--GHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSASVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVGQVACGSSHTIAVSQDGRIVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQLYAWG 646
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Sea Lamprey
Match: rcc2 (regulator of chromosome condensation 2 [Source:NCBI gene;Acc:406455]) HSP 1 Score: 52.7582 bits (125), Expect = 1.260e-7 Identity = 64/273 (23.44%), Postives = 103/273 (37.73%), Query Frame = 2
Query: 578 ACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIG-----------CC-------SSFIQITGG-----IENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWG 1327
ACG H++ + T+ +Y G N+ GQ G + N+ S + + + +V CG + + DG+++ G +YGQL + G C + FI+ T + VV+ ++C N +AL G V+ WG + + E + L V V AG + ++ G L+ WG + + PT+ P D + V +ACG K S ITS S WG
Sbjct: 112 ACGRSHTLCL-------TDTGTVYAFGENRLGQLG---LGNQTDAVPSPTQIVYSGRQVVKVACGAEFSVFIDCDGNLFSFGCPEYGQLGHNTDGRYIVRAQRIEFVCELAPRRLARFIEKTRDGQVLTVRGVVVRDVACGANHTIALDTRGRVFTWGFGGYGRLGHAEQKDELLPRLVKLLDRPAPAVNSVRAGYSCTFAINVVGTLYFWG--------STNTSRDPTMYPKAVH-------DLCGTHVRSLACG-KSSILITSDESTMSWG 358 HSP 2 Score: 48.1358 bits (113), Expect = 2.937e-6 Identity = 50/211 (23.70%), Postives = 84/211 (39.81%), Query Frame = 2
Query: 767 CGEVTTFILTEDGSVYGCGSNQYGQLA-SSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNL-----PETIGKVIQ-----------------VSAGSTTCAILDDKGQLHTWGMYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGN 1330
CG T LT+ G+VY G N+ GQL + S QI + V +++C + + DG ++ +G E+ + + D + R+ P + + I+ V+ G+ LD +G++ TWG G G ++ ++P +LLD V V G + AI G+LY WG+
Sbjct: 113 CGRSHTLCLTDTGTVYAFGENRLGQLGLGNQTDAVPSPTQIV--YSGRQVVKVACGAEFSVFIDCDGNLFSFGCPEYGQLGHNTDGRYIVRAQRIEFVCELAPRRLARFIEKTRDGQVLTVRGVVVRDVACGANHTIALDTRGRVFTWGFG--GYGRLGHAEQKDELLPRLV-----KLLDRPAPAVNSVRAGYSCTFAINVVGTLYFWGS 314
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Sea Lamprey
Match: NEK9 (NIMA related kinase 9 [Source:HGNC Symbol;Acc:HGNC:18591]) HSP 1 Score: 52.7582 bits (125), Expect = 1.389e-7 Identity = 48/165 (29.09%), Postives = 74/165 (44.85%), Query Frame = 2
Query: 656 GNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSF-IQITGGIENKV-----VKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQL 1132
G GQ G + D YR + + +RQV CG+ T LTE G V+ GS+ YG + GC +++ + + V QISC V+ALT G V+ WG E+ + + D + F P R+ L K+ +V G+ L +G++
Sbjct: 380 GTKMVGQLGHK--DKASYRQPKRVDKL-LGLAVRQVACGDEFTVCLTEQGEVFSFGSDYYGCM-----GCNGELGVEVLEPMPVQFFNINPVTQISCGDCHVMALTRSGAVYAWGCGEYGRLGLETD-ATEFYPKRVPLSNRW-KITEVCCGTDGTFFLTAQGKV 534 HSP 2 Score: 47.3654 bits (111), Expect = 7.500e-6 Identity = 71/312 (22.76%), Postives = 131/312 (41.99%), Query Frame = 2
Query: 371 ISIRKAATGYGFTLFSGKS----SIGWHVYGCGVNHDSQLGLQPHSSNINGFPILMEPSEIPLPEKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSS---------FIQITGGIENKVVKQISC-RCNTV-------LALTEDGEVWGWGNNEHNAIFSDEDHSCTFKP---IRLNLPETIGKVI-QVSAGS-TTCAILDDKGQLHTWGMY---IVGLGPNKIVCKQPTVIPAPFFG 1219
+++R+ A G FT+ + S G YGC + + +LG++ ++EP + + + I+CG H + + T + +Y G ++G+ G + E Y + I +V CG TF LT G V CG+N++ +L + C+S F ++ + +VKQ+S + ++ + G + +G+N+H + + + FK I L+ +GK+I VS G T A + ++ WG +G+ P++ P +P P FG
Sbjct: 407 LAVRQVACGDEFTVCLTEQGEVFSFGSDYYGC-MGCNGELGVE-----------VLEPMPVQFF-NINPVTQISCGDCHVMAL-------TRSGAVYAWGCGEYGRLGLETDATEFYPKRVPLSN---RWKITEVCCGTDGTFFLTAQGKVLACGNNEFNKLG---LNQCTSGLRNRETSVFHEVIMKLMPTLVKQLSIYKIRSISGGKTHSAVIDVCGRLLTFGHNKHGQLGTGD-----FKKHLGIVLHKGPLVGKLITMVSCGDGFTIAATEADNHIYAWGNTDNGRLGVMPSEKPGNSPLALPRPIFG 687
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Sea Lamprey
Match: rcc1 (regulator of chromosome condensation 1 [Source:ZFIN;Acc:ZDB-GENE-040426-2216]) HSP 1 Score: 48.9062 bits (115), Expect = 1.884e-6 Identity = 69/294 (23.47%), Postives = 106/294 (36.05%), Query Frame = 2
Query: 506 NGFPILMEPS-EIPLPEKVK---GINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGR--QIIDNEIYRGSSVIHGIKFDKPIR-----------QVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMY---IVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWG 1327
NG L+EP + PLP K+ I +A G H V+++E ++ IYTLG + GQ GR ++ N R + + ++ V CG TF L+ DGS+YG G + Y QL ++ K S +L E+ E W +++ G LD G++++ G +GLG PT++P P S + +ACG S A+T G + WG
Sbjct: 150 NGIIGLLEPMMKCPLPTKLTLDTRIVKVASGNDHLVLLSE-------SRQIYTLGCGEQGQLGRVAEMFANRGGRRGLLRLLVPEQVRVKARRGHSHVEFLDVFCGSYFTFALSTDGSLYGFGLSNYHQLGTA--------------------KPDSAFVPNLLTSFENSETW----------------------------------LELCGGQHHSLCLDSGGKVYSLGRADYGRLGLGKGACDVALPTLVPTP-------------SHINSIACGASVSYAVTKDGRAFSWG 369
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Yeast
Match: SRM1 (Nucleotide exchange factor for Gsp1p; localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p; human homolog of the RAN GEF, RCC1, can complement a temperature sensitive point mutant [Source:SGD;Acc:S000003065]) HSP 1 Score: 55.4546 bits (132), Expect = 1.097e-8 Identity = 73/283 (25.80%), Postives = 114/283 (40.28%), Query Frame = 2
Query: 548 PEKVKGINFIACGLGHSVI-VAEIDAIDT---NNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKP------IRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHN--AIFSD-EDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWG---MYIVGLGPN-------KIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWG 1327
P K+ +F GH V+ +A D + +N +Y G + C I+ Y+ I + P I Q+ G+ L E+G V+ G+ Q QL + + VK I+ N ALT+D ++ WG N+ + D ED + KP RL LP+ + + ++AG IL G L++ G M+ VG+ + K V + +P P ++L N K VA G +S A+ G Y WG
Sbjct: 150 PAKIPRESFPPLAEGHKVVQLAATDNMSCALFSNGEVYAWGTFR---CNEGILG--FYQDKIKIQKTPWKVPTFSKYNIVQLAPGKDHILFLDEEGMVFAWGNGQQNQLGRKVMERFRLKTLDPRPFGLRHVKYIASGENHCFALTKDNKLVSWGLNQFGQCGVSEDVEDGALVTKPKRLALPDNV-VIRSIAAGEHHSLILSQDGDLYSCGRLDMFEVGIPKDNLPEYTYKDVHGKARAVPLP-----TKL--NNVPKFKSVAAGSHHSVAVAQNGIAYSWG 419 HSP 2 Score: 51.2174 bits (121), Expect = 2.092e-7 Identity = 52/233 (22.32%), Postives = 98/233 (42.06%), Query Frame = 2
Query: 362 FQKISIRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGLQPHSSNINGFPILMEPSEI----PLPEKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKP----IRQVECGEVTTFILTEDGSVYGCG----------SNQYGQLASSDIGCCSSFIQITGGIEN-KVVKQISCRCNTVLALTEDGEVWGWGNNEHNAI 1003
F K +I + A G LF + + V+ G +QLG + +ME + P P ++ + +IA G H A+ +N+++ + G N+FGQCG + ++ G+ V + P IR + GE + IL++DG +Y CG + + D+ + + + + N K ++ + +A+ ++G + WG E A+
Sbjct: 218 FSKYNIVQLAPGKDHILFLDEEGM---VFAWGNGQQNQLGRK-----------VMERFRLKTLDPRPFGLRHVKYIASGENHCF------ALTKDNKLV-SWGLNQFGQCG---VSEDVEDGALVTKPKRLALPDNVVIRSIAAGEHHSLILSQDGDLYSCGRLDMFEVGIPKDNLPEYTYKDVHGKARAVPLPTKLNNVPKFKSVAAGSHHSVAVAQNGIAYSWGFGETYAV 426
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Nematostella
Match: EDO46355 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RQF3]) HSP 1 Score: 84.7297 bits (208), Expect = 1.002e-17 Identity = 71/272 (26.10%), Postives = 116/272 (42.65%), Query Frame = 2
Query: 530 PSEIPLP---EKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDK--PIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAI--FSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVW 1324
P I LP EK + I IACG H++++ T+++ ++ +G N GQCG + +++ S H D I +V CG + +L+ DG V+ CG GQ Q+ G + +K IS + LA++EDG+V+ WGN+E+ I SDE G +++WG ++G G + K+P I A +D ++ + CG+ ++A T G L+VW
Sbjct: 93 PRSIDLPVFCEKTR-ITQIACGRSHALVL-------TDSEGVFVIGGNSQGQCGFGGVTDKV---KSFQHLPLPDATGAIVKVVCGMDHSLLLSCDGKVFSCGWGADGQTGLGFFDDAVKVSQLEGELSGVKIKDISSAVDCCLAVSEDGDVFSWGNSEYAQIGLMSDEKQ---------------------------------DGSMYSWGYGVLGHGSDVTFSKEPIRIQA---------VDDVSERITELYCGLDHAAFTTESGKLFVW 311
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Nematostella
Match: EDO44704 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RV05]) HSP 1 Score: 83.1889 bits (204), Expect = 2.374e-17 Identity = 83/295 (28.14%), Postives = 132/295 (44.75%), Query Frame = 2
Query: 575 IACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVG-LGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGN------DIVSGAYNQTFPVRMP--ATFHAKTLYMGADHSIIV 1432
++CG HS +V T N +YT G N +GQ G + + Y SV+ +K +K + V CG T TE G +Y G GQL D S +I G++ + K ++C + A+TE+GE++ WG+ ED T P RL+L GKV VS G A++ + G L+ G G LG + + + + + + +VV ACG +++A +T GS+Y +G + S FP R+P A+T+ G + ++
Sbjct: 40 LSCGDEHSAVV-------TANGKLYTFGCNDWGQLGHG--NTKSYTKPSVVKKLKPEK-VYMVACGRNHTIAATESGHLYSFGCGGDGQLGHGDAE-DSHVPKIIEGLDVQKYKHLACGSDFSAAITENGELYTWGSCGEGQNGLGED---TEIPTRLHLH---GKVRMVSCGYYHMAVVTEDGSLYMCGEKEGGKLGLDHEQLDNTSQL---------QKIKSIEDQVVVAACGAEFTAVVTKNGSVYTFGQGNQGQLGLGSSMMETEFPERIPLFEKVKARTVSCGESFTAVI 308 HSP 2 Score: 56.6102 bits (135), Expect = 9.582e-9 Identity = 85/346 (24.57%), Postives = 144/346 (41.62%), Query Frame = 2
Query: 131 FNQIRSFGVKRATKDYIRNTEIY------DYSTNPPKNSYLGVFGVASTGALGIKRLINNERIKNLHIARRVYPLYYFNDLVNFQKISIRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGL-QPHSSNINGFPILMEPSEIPLPEKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLA-SSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWG 1144
F + R F A K +IR+ + ++S N L FG G LG N + + +++ P +K+ + A G T+ + +S H+Y G D QLG S++ P ++E ++ +K K +ACG ++ A T N +YT G+ GQ N + + + + +R V CG ++TEDGS+Y CG + G+L + +S +Q IE++VV +C +T++G V+ +G + T P R+ L E + K VS G + A++ G L+T+G
Sbjct: 17 FGKTR-FADNLANKFWIRDDAVVNLSCGDEHSAVVTANGKLYTFGCNDWGQLGHG---NTKSYTKPSVVKKLKP----------EKVYM--VACGRNHTIAATESG---HLYSFGCGGDGQLGHGDAEDSHV---PKIIEGLDV---QKYK---HLACG-------SDFSAAITENGELYTWGSCGEGQ-------NGLGEDTEIPTRLHLHGKVRMVSCGYYHMAVVTEDGSLYMCGEKEGGKLGLDHEQLDNTSQLQKIKSIEDQVV-VAACGAEFTAVVTKNGSVYTFGQGNQGQLGLGSSMMETEFPERIPLFEKV-KARTVSCGESFTAVITKHGNLYTFG 318 HSP 3 Score: 55.8398 bits (133), Expect = 1.722e-8 Identity = 54/199 (27.14%), Postives = 91/199 (45.73%), Query Frame = 2
Query: 743 DKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQ--ITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPNKIVCKQPTVIPAPFFGGGSRL-LDGNKSKVVRVACGVKYSAAITSYGSLYVWGN 1330
D + + CG+ + ++T +G +Y G N +GQL G S+ + + ++ + V ++C N +A TE G ++ +G + + I L + K ++ GS A + + G+L+TWG G G N + + T IP +RL L G KV V+CG + A +T GSLY+ G
Sbjct: 34 DDAVVNLSCGDEHSAVVTANGKLYTFGCNDWGQLGH---GNTKSYTKPSVVKKLKPEKVYMVACGRNHTIAATESGHLYSFGCGGDGQLGHGDAEDSHVPKIIEGLD--VQKYKHLACGSDFSAAITENGELYTWGS--CGEGQNGL--GEDTEIP-------TRLHLHG---KVRMVSCGYYHMAVVTEDGSLYMCGE 213
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Nematostella
Match: EDO37196 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SGI6]) HSP 1 Score: 77.411 bits (189), Expect = 8.942e-15 Identity = 88/324 (27.16%), Postives = 142/324 (43.83%), Query Frame = 2
Query: 353 LVNFQKISIRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGLQPHSS-NINGFPILMEPSEIPLPEKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECG--EVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAI-FSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWG---MYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITS 1303
L + Q + +RK A G S+ G VY G D +LG H + N P ++E + KG+ I+CG HS + T N +YT G ++G+ G D+E V+ ++ ++ I V CG + T LT+D V+ G YG+L C +++ I V K + C +ALT G V+ WG ++ + +DH +P R+ + KVI ++ GS C D G+++TWG +G G + + P ++ A L G K+ RVACG ++ A ++
Sbjct: 3433 LESLQHVVVRKVAVHSGGKHAMALSADG-DVYSWGEGDDGKLG---HGNRNSCDRPRVIEAL------RGKGVIDISCGGSHSACI-------TQNHELYTWGKGRYGRLGHG--DSEDQLLPKVVEALRGNRVI-DVACGSGDAQTLCLTDDDCVWSWGDGDYGKLGRGGSDGCKIPMKVESLIGLGVSK-VECGSQFSVALTRSGAVYTWGKGDYYRLGHGVDDH--VRRPKRVAALQG-KKVITIATGSLHCVASTDTGEVYTWGDNDEGQLGDGTTNAIAR-PRLVTA---------LQGK--KISRVACGSAHTIAWST 3720 HSP 2 Score: 71.2478 bits (173), Expect = 7.215e-13 Identity = 78/256 (30.47%), Postives = 113/256 (44.14%), Query Frame = 2
Query: 575 IACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECG--EVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAI-FSDEDHSCTFKPIRLNLPETI-GK-VIQVSAGSTTCAILDDKGQLHTWGMYIVG-LGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSK-VVRVACGVKYSAAITSYGSLYV 1321
I+CG HS V T+ +YT G +G+ G ++++ ++ G++ I V CG + T +DG+V+ G YG+L C + I ++ V ++ C LALT DG VW WG E + EDH K L E + GK V+ VS GS C L D G+++ WG G LG I C+ + P P L+ G SK +V +ACG S A + G V
Sbjct: 74 ISCGSTHSAAV-------TSEGELYTWGRGNYGRLGHGSSEDQLV--PVLVSGLR-GHHIIDVACGSGDAHTLAAADDGTVWSWGDGDYGKLGRGGSDGCKNPKSIER-LQGLGVCKVYCGAQFSLALTRDGSVWTWGKGEGFRLGHGTEDHVRHPK-----LVEALDGKHVVDVSVGSIHCLALTDAGEVYCWGRNDQGQLG--DIDCQ---IRPEP------TLVSGLASKGIVGIACGPAQSFAWSCAGQWSV 302 HSP 3 Score: 67.781 bits (164), Expect = 7.200e-12 Identity = 81/331 (24.47%), Postives = 135/331 (40.79%), Query Frame = 2
Query: 443 VYGCGVNHDSQLGLQPHSSNINGFPILMEPSEIPLPEKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLG---NNKFGQCGRQIIDN----EIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISC--RCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGK-----VIQVSAGSTTCAILDDKGQLHTWG---MYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNK-SKVVRVACGVKYSAAITSYGSLYVWG-NDIVSGAYNQTFPVRMP 1378
V+ CG + + +LGL P S+N+ P +E + KV + G H++ + T +++ G + K G R D+ + ++ S V R + CG + + G +Y G +YG+L D ++ ++V+ I+C R LALT+DG VW WG+ + + C+ +P + K V +V+ G+ L G + TWG Y +G G N ++P ++ DG + K+V VA G + A+T G ++ WG ND N T R P
Sbjct: 2475 VFACGESTNGRLGLGPLSANVT-VPRQIENLSSFMVRKVS----VHSGGRHAMAL-------TIEGKLFSWGEGEDGKLGHGNRMNCDHPKLIDTFKSSCV----------RDMSCGSSHSAAILSSGELYTWGLGEYGRLGHGDNYTHLKPKKVQSFTSHRVI-DIACGSRDAQTLALTDDGTVWSWGDGDFGKLGRGGSEGCS-------VPNPVEKLQGQGVCKVACGAQFSLALSTSGLVWTWGKGDYYRLGHG-NDTHVRKPQIV------------DGLRGKKIVDVAVGALHCLAVTDSGQVFAWGDNDHGQQGNNTTTVNRRP 2762 HSP 4 Score: 66.6254 bits (161), Expect = 1.953e-11 Identity = 62/249 (24.90%), Postives = 108/249 (43.37%), Query Frame = 2
Query: 575 IACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECG--EVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIG-----KVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPNKI--VCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAA 1294
++CG HS AI ++ ++ YT G ++G+ G DN + + + I + CG + T LT+DG+V+ G +G+L CS + ++ + V +++C LAL+ G VW WG ++ + D + P+ + K++ V+ G+ C + D GQ+ WG G N V ++P ++ L+G K + RVACG +S A
Sbjct: 2566 MSCGSSHSA------AILSSGEL-YTWGLGEYGRLGHG--DNYTHLKPKKVQSFTSHRVI-DIACGSRDAQTLALTDDGTVWSWGDGDFGKLGRGGSEGCSVPNPVEK-LQGQGVCKVACGAQFSLALSTSGLVWTWGKGDYYRLGHGND-------THVRKPQIVDGLRGKKIVDVAVGALHCLAVTDSGQVFAWGDNDHGQQGNNTTTVNRRPQLVNG---------LEGQK--ITRVACGSSHSIA 2785 HSP 5 Score: 60.4622 bits (145), Expect = 1.430e-9 Identity = 60/239 (25.10%), Postives = 101/239 (42.26%), Query Frame = 2
Query: 644 IYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQ----ITGGIENKVVKQISCRCNT--VLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGM---YIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGND 1333
+Y+ G+ G+ G D +++ G+ + IR + CG + +T +G +Y G YG+L G SS Q + G+ + ++C LA +DG VW WG+ ++ + C P + + +G V +V G+ L G + TWG + +G G V + P ++ A LDG VV V+ G + A+T G +Y WG +
Sbjct: 38 VYSWGSGDGGKLGHG--DTSPREEPTLVTGLAGKQVIR-ISCGSTHSAAVTSEGELYTWGRGNYGRL-----GHGSSEDQLVPVLVSGLRGHHIIDVACGSGDAHTLAAADDGTVWSWGDGDYGKLGRGGSDGCK-NPKSIERLQGLG-VCKVYCGAQFSLALTRDGSVWTWGKGEGFRLGHGTEDHV-RHPKLVEA---------LDGK--HVVDVSVGSIHCLALTDAGEVYCWGRN 254 HSP 6 Score: 59.3066 bits (142), Expect = 3.257e-9 Identity = 61/243 (25.10%), Postives = 98/243 (40.33%), Query Frame = 2
Query: 644 IYTLG---NNKFGQCGRQIIDN----EIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCN--TVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIG-KVIQVSAGSTTCAILDDKGQLHTWG---MYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGND 1333
+Y+ G + K G R D E RG VI + CG + +T++ +Y G +YG+L D ++ + V ++C L LT+D VW WG+ ++ + C I + + IG V +V GS L G ++TWG Y +G G + V ++P + A L G K V+ +A G + A T G +Y WG++
Sbjct: 3462 VYSWGEGDDGKLGHGNRNSCDRPRVIEALRGKGVI----------DISCGGSHSACITQNHELYTWGKGRYGRLGHGD-SEDQLLPKVVEALRGNRVIDVACGSGDAQTLCLTDDDCVWSWGDGDYGKLGRGGSDGCK---IPMKVESLIGLGVSKVECGSQFSVALTRSGAVYTWGKGDYYRLGHGVDDHV-RRPKRVAA---------LQGKK--VITIATGSLHCVASTDTGEVYTWGDN 3678 HSP 7 Score: 59.3066 bits (142), Expect = 3.519e-9 Identity = 49/203 (24.14%), Postives = 93/203 (45.81%), Query Frame = 2
Query: 752 IRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENK---VVKQISCRCNT--VLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGM---YIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVK--YSAAITSYGSLYVWGN 1330
++Q+ G T F ++ DG V+ CG + G+L +G S+ + + IEN +V+++S +ALT +G+++ WG E + +C + + V +S GS+ A + G+L+TWG+ +G G N K ++ +V+ +ACG + + A+T G+++ WG+
Sbjct: 2456 VQQIAGGSKTLFAVSHDGKVFACGESTNGRLG---LGPLSANVTVPRQIENLSSFMVRKVSVHSGGRHAMALTIEGKLFSWGEGEDGKLGHGNRMNCDHPKLIDTFKSSC--VRDMSCGSSHSAAILSSGELYTWGLGEYGRLGHGDNYTHLKP------------KKVQSFTSHRVIDIACGSRDAQTLALTDDGTVWSWGD 2641 HSP 8 Score: 55.8398 bits (133), Expect = 4.005e-8 Identity = 70/277 (25.27%), Postives = 116/277 (41.88%), Query Frame = 2
Query: 644 IYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRC--NTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETI-GK-VIQVSAGSTTCAILDDKGQLHTWGMYIVG-LGPN--------KIV--CKQPTVIPAPFFGGGSRLL------------DGNKSK----------------------VVRVACGVKYSAAITSYGSLYVWG 1327
IY G+N GQ G ++ + I + +P+ Q+ GE T F +T +G VY G G+L +S I++ +++ VV++++ +AL+ DG+V+ WG + + +SC R + E + GK VI +S G + A + +L+TWG G LG K+V + VI G ++ L DG+ K V +V CG ++S A+T G++Y WG
Sbjct: 3356 IYGWGHNHRGQLGS--LEGAKVKLPQTIEALASIRPV-QIVGGEQTLFAVTAEGKVYATGYGHGGRLGLGGTDTVTS-IKMLESLQHVVVRKVAVHSGGKHAMALSADGDVYSWGEGDDGKLGHGNRNSCD----RPRVIEALRGKGVIDISCGGSHSACITQNHELYTWGKGRYGRLGHGDSEDQLLPKVVEALRGNRVIDVACGSGDAQTLCLTDDDCVWSWGDGDYGKLGRGGSDGCKIPMKVESLIGLGVSKVECGSQFSVALTRSGAVYTWG 3624 HSP 9 Score: 54.6842 bits (130), Expect = 8.876e-8 Identity = 57/187 (30.48%), Postives = 83/187 (44.39%), Query Frame = 2
Query: 791 LTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIF--SDEDHSCTFKPIRLNLPETIGKVIQVSAGST---TCAILDDKGQLHTWG---MYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWG 1327
LT +G VY GS G+L D +TG + K V +ISC A+T +GE++ WG + + S ED P+ ++ +I V+ GS T A DD G + +WG +G G + CK P I RL V +V CG ++S A+T GS++ WG
Sbjct: 32 LTREGEVYSWGSGDGGKLGHGDTSPREEPTLVTG-LAGKQVIRISCGSTHSAAVTSEGELYTWGRGNYGRLGHGSSEDQ---LVPVLVSGLRG-HHIIDVACGSGDAHTLAAADD-GTVWSWGDGDYGKLGRGGSD-GCKNPKSI--------ERL---QGLGVCKVYCGAQFSLALTRDGSVWTWG 200 HSP 10 Score: 51.2174 bits (121), Expect = 1.115e-6 Identity = 49/177 (27.68%), Postives = 76/177 (42.94%), Query Frame = 2
Query: 803 GSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVG-LG-PNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWG 1327
G++YG G N GQL S + G Q + + QI T+ A+T +G+V+ G + + T + +L + + + V +G L G +++WG G LG N+ C +P VI A G G V+ ++CG +SA IT LY WG
Sbjct: 3354 GTIYGWGHNHRGQLGSLE-GAKVKLPQTIEALASIRPVQIVGGEQTLFAVTAEGKVYATGYGHGGRLGLGGTDTVTSIKMLESLQHVVVRKVAVHSGGKHAMALSADGDVYSWGEGDDGKLGHGNRNSCDRPRVIEA-LRGKG----------VIDISCGGSHSACITQNHELYTWG 3518
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Nematostella
Match: EDO49099 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RI68]) HSP 1 Score: 73.559 bits (179), Expect = 8.303e-14 Identity = 82/299 (27.42%), Postives = 128/299 (42.81%), Query Frame = 2
Query: 587 LGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISC---RCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVG-LGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGNDIVS--GA-----------YNQTFPVRMPATFHAKTLYMGADHSIIV 1432
LG + + + DA D IYT G G G E + V+ + K IR+V CG T L++DG V+ GS G+L + + I+I G +E+ + Q++C V A ++ G ++ +G N++ + ED T I+ + K+ +V+ GS A L + G L WG G LG T +P+ G D V+ VACG ++SA IT G ++ G++ GA YN VR+P F + G H+ +V
Sbjct: 195 LGQATVHVKEDACD-----IYTWGEGTNGMLGHGEDTQEAH--PHVVEAL-LGKDIRKVACGATHTLALSKDGEVFSWGSGYGGRLGQGHLRDRFTPIRICG-LESLNLTQVACNEFHSAAVCACSKQGALFSFGENDYGQLGIPEDKLLT-SYIQCVSSLSEHKISRVACGSFHSAALAEHGSLWLWGCNESGQLGNGNYT---STSLPSLLEAGN----DLRHDAVMEVACGDQHSAFITKKGRMFCCGDNTYGQLGAHLNDNQDDHVTYNVAVRVRVPTDFRCVHVACGDSHTAVV 476 HSP 2 Score: 60.8474 bits (146), Expect = 7.553e-10 Identity = 58/262 (22.14%), Postives = 114/262 (43.51%), Query Frame = 2
Query: 560 KGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFIL---TEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETI--GKVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGN 1330
K I +ACG H++ +++ + +++ G+ G+ G+ + + I G++ + QV C E + + ++ G+++ G N YGQL + +S+IQ + + +++C AL E G +W WG NE + + +++ T P L + V++V+ G A + KG++ G G + Q + + R+ + V VACG ++A +T G ++ WG
Sbjct: 240 KDIRKVACGATHTLALSK-------DGEVFSWGSGYGGRLGQGHLRDRFT--PIRICGLE-SLNLTQVACNEFHSAAVCACSKQGALFSFGENDYGQLGIPEDKLLTSYIQCVSSLSEHKISRVACGSFHSAALAEHGSLWLWGCNESGQL-GNGNYTSTSLPSLLEAGNDLRHDAVMEVACGDQHSAFITKKGRMFCCGDNTYGQLGAHLNDNQDDHVT---YNVAVRVRVPTDFRCVHVACGDSHTAVVTDGGEIFTWGR 487
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Nematostella
Match: EDO34592 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SNX9]) HSP 1 Score: 73.559 bits (179), Expect = 9.100e-14 Identity = 60/236 (25.42%), Postives = 101/236 (42.80%), Query Frame = 2
Query: 644 IYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIG-----KVIQVSAGSTTCAILDDKGQLHTWGMYIVG-LGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGND 1333
++ G GQ G + E ++ ++F +R+V CG T L +DG+VY CGSN++GQL + IE + +++C +A+++ G V+ WG+N + I K +P+ + V+Q++ G L G L WG G LG K PAP +L N + ++ G +S A++S G+L+ WG +
Sbjct: 1 MFCWGKCSEGQLGVGETEQEFISTPRLLENLEFSSNVREVSCGWNHTAFLCKDGTVYTCGSNEFGQLGQEKSHTNPESVH---AIETFTITKVTCGKAHTVAVSDQGLVFAWGDNSYGQI----GLGSKVKEKVQTIPKMLKGLAKMSVVQIACGCNHSMALTISGHLFCWGDNSSGQLGIGKTHSSMSE--PAP-------VLSLNGVPFMLISAGGAHSFALSSSGALFGWGKN 220 HSP 2 Score: 62.7734 bits (151), Expect = 2.572e-10 Identity = 79/327 (24.16%), Postives = 128/327 (39.14%), Query Frame = 2
Query: 374 SIRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGLQPHSSNINGFPILMEPSEIPLPEKVKGINF-----IACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGR-QIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGK-VIQVSAGSTTCAILDDKGQLHTWGMYIVG-LGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAIT-SYGSLYVWG 1327
++R+ + G+ T F K VY CG N QLG + +N PE V I + CG H+V V ++ +++ G+N +GQ G + ++ ++ G+ + Q+ CG + LT G ++ G N GQL S + IS AL+ G ++GWG NE+ + H T +P+ L + V VS G A+L G + T+G G LG N P ++ + S V ++ACG ++ A+ S G +Y +G
Sbjct: 36 NVREVSCGWNHTAFLCKDGT---VYTCGSNEFGQLGQEKSHTN---------------PESVHAIETFTITKVTCGKAHTVAV-------SDQGLVFAWGDNSYGQIGLGSKVKEKVQTIPKMLKGLA-KMSVVQIACGCNHSMALTISGHLFCWGDNSSGQLGIGKTHSSMSEPAPVLSLNGVPFMLISAGGAHSFALSSSGALFGWGKNEYGQLGV---HDTTDRPLPTLLKSLRSQGVCYVSCGEKHTAVLTSDGGVFTFGCGTSGQLGHNS---NHHEYTP-------RKVFELMGSVVTQIACGRAHTLALVPSSGRVYTFG 323
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Medaka
Match: rcc1l (RCC1 like [Source:NCBI gene;Acc:101155627]) HSP 1 Score: 209.149 bits (531), Expect = 2.256e-61 Identity = 136/410 (33.17%), Postives = 212/410 (51.71%), Query Frame = 2
Query: 239 VFGVASTGALGIKRLI--NNERIKNLHIARRVYPLYYFNDLVNFQKISIRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGLQ-PHSSNINGFPILMEPSEIPLPEK---VKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIK-FDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGNDI-----VSGAYNQTFPVRMPATFHAKTLYMGADHSIIV 1432
V+G + TGALGI + ++ R K Y L +I AA GYGFTL + + V+G G+N DSQLG Q S + + ++EPS + LP K + +ACG HS+I+ T+ + +++LGNN FGQCGR+I+ +E+Y S VIH ++ F + QV CG+ + +LTE G V+ CG GQ S+ +++ G + V+Q+S + LA++ DG+++GWGN+E+ + S + + P L L + G V+Q + G T A+L++KG++ WG I+G GPN P +IP FG R + V R+ CG+ + AA+T G L+VWG +I + +Q FP R+ + G DH + +
Sbjct: 56 VWGFSFTGALGIPSFVVPDSGRKKPRKCQLTPYRLETAE--------TISSAACGYGFTLLASSTKDVSKVWGMGLNKDSQLGFQRTQRSRHHSYHYVLEPSPVALPLKEPLQTRVVQVACGRAHSLIL-------TDREGVFSLGNNAFGQCGRRIVRDEVYSDSHVIHKMEGFGDKVVQVSCGQDHSLLLTESGRVFACGWGADGQTGLGHHNISSTPVEVGGDLSGVEVQQVSTYGDCSLAVSRDGQLFGWGNSEYRQLSSVTESTQMNSPRHLPL-KGCGTVVQAACGGTQVAVLNEKGEVFVWGYGILGKGPNLSESSTPELIPPTLFG---RSEFSPSAAVSRIRCGLGHFAAVTEGGELFVWGKNIRGCLGIGKRDDQFFPWRVTVPGRVVDVACGVDHMVAL 446
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Medaka
Match: rcc1l (RCC1 like [Source:NCBI gene;Acc:101155627]) HSP 1 Score: 205.297 bits (521), Expect = 1.108e-59 Identity = 133/391 (34.02%), Postives = 206/391 (52.69%), Query Frame = 2
Query: 239 VFGVASTGALGIKRLI--NNERIKNLHIARRVYPLYYFNDLVNFQKISIRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGLQ-PHSSNINGFPILMEPSEIPLPEK---VKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIK-FDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGNDI-----VSGAYNQTFPVRM 1375
V+G + TGALGI + ++ R K Y L +I AA GYGFTL + + V+G G+N DSQLG Q S + + ++EPS + LP K + +ACG HS+I+ T+ + +++LGNN FGQCGR+I+ +E+Y S VIH ++ F + QV CG+ + +LTE G V+ CG GQ S+ +++ G + V+Q+S + LA++ DG+++GWGN+E+ + S + + P L L + G V+Q + G T A+L++KG++ WG I+G GPN P +IP FG R + V R+ CG+ + AA+T G L+VWG +I + +Q FP R+
Sbjct: 56 VWGFSFTGALGIPSFVVPDSGRKKPRKCQLTPYRLETAE--------TISSAACGYGFTLLASSTKDVSKVWGMGLNKDSQLGFQRTQRSRHHSYHYVLEPSPVALPLKEPLQTRVVQVACGRAHSLIL-------TDREGVFSLGNNAFGQCGRRIVRDEVYSDSHVIHKMEGFGDKVVQVSCGQDHSLLLTESGRVFACGWGADGQTGLGHHNISSTPVEVGGDLSGVEVQQVSTYGDCSLAVSRDGQLFGWGNSEYRQLSSVTESTQMNSPRHLPL-KGCGTVVQAACGGTQVAVLNEKGEVFVWGYGILGKGPNLSESSTPELIPPTLFG---RSEFSPSAAVSRIRCGLGHFAAVTEGGELFVWGKNIRGCLGIGKRDDQFFPWRV 427
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Medaka
Match: rcc1l (RCC1 like [Source:NCBI gene;Acc:101155627]) HSP 1 Score: 177.178 bits (448), Expect = 6.495e-50 Identity = 123/406 (30.30%), Postives = 188/406 (46.31%), Query Frame = 2
Query: 239 VFGVASTGALGIKRLI--NNERIKNLHIARRVYPLYYFNDLVNFQKISIRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGLQPHSSNINGFPILMEPSEIPLPEKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIK-FDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGNDI-----VSGAYNQTFPVRMPATFHAKTLYMGADHSIIV 1432
V+G + TGALGI + ++ R K Y L +I AA GYGFTL + + V+G G+N DSQLG Q T +++LGNN FGQCGR+I+ +E+Y S VIH ++ F + QV CG+ + +LTE G V+ CG GQ S+ +++ G + V+Q+S + LA++ DG+++GWGN+E+ + S + + P L L + G V+Q + G T A+L++KG++ WG I+G GPN P +IP FG R + V R+ CG+ + AA+T G L+VWG +I + +Q FP R+ + G DH + +
Sbjct: 56 VWGFSFTGALGIPSFVVPDSGRKKPRKCQLTPYRLETAE--------TISSAACGYGFTLLASSTKDVSKVWGMGLNKDSQLGFQ----------------------------------------------RTQRSRLFSLGNNAFGQCGRRIVRDEVYSDSHVIHKMEGFGDKVVQVSCGQDHSLLLTESGRVFACGWGADGQTGLGHHNISSTPVEVGGDLSGVEVQQVSTYGDCSLAVSRDGQLFGWGNSEYRQLSSVTESTQMNSPRHLPL-KGCGTVVQAACGGTQVAVLNEKGEVFVWGYGILGKGPNLSESSTPELIPPTLFG---RSEFSPSAAVSRIRCGLGHFAAVTEGGELFVWGKNIRGCLGIGKRDDQFFPWRVTVPGRVVDVACGVDHMVAL 403
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Medaka
Match: rcbtb1 (RCC1 and BTB domain-containing protein 1 [Source:NCBI gene;Acc:101165789]) HSP 1 Score: 85.8853 bits (211), Expect = 2.243e-17 Identity = 95/338 (28.11%), Postives = 147/338 (43.49%), Query Frame = 2
Query: 329 YPLYYFNDLVNFQKISIRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGLQPHSSNINGFPILMEPSEIPLPEKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVG-LGP-NKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVAC--GVKYSAAITSYGSLYVWGN 1330
+PL F+ L + + S+R+A + S G V+ G+N + LG + S I P ++ + K ++ ++ G G V++A N ++ G+N + Q G + E+ +I G DK + +V CG + L EDG V+ G N GQ+ S +ITGG++ K+ I+C + +AL GEV+ WG N N ++ P RL + + V ++ AG C L D+G L+ WG G LG NK P I A +K +VV VA SAA T G +Y+WG
Sbjct: 7 WPL--FSLLSSEDRASVRQACVFGTSANEAVYVSHGNEVFAFGLNSNGCLGTGDYCSTI-------VPKKLNFLQGKKVVS-LSYGSGPHVLLA------AENGQLFAWGHNGYSQLGNGTTNQEL--SPVLISGHLQDKKVTKVACGSHHSMALMEDGEVFAWGYNNCGQVGSGSTANQPYPRRITGGLQGKLAVDITCGQTSSMALVNSGEVYAWGYNG-NGQLGIGNNGNQPSPSRLAAFQGLC-VQRIVAGYGHCLALTDEGALYAWGANTFGQLGTGNKSNHLSPVRIMA------------DKERVVEVAACHSTHISAAKTRTGEVYMWGQ 312 HSP 2 Score: 68.1662 bits (165), Expect = 1.023e-11 Identity = 59/226 (26.11%), Postives = 100/226 (44.25%), Query Frame = 2
Query: 785 FILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMY---IVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGNDI-----VSGAYNQTFPVRMPATFHAKTLYMGADHSIIVGA 1438
+ E+G ++ G N Y QL + S + I+G +++K V +++C + +AL EDGEV+ WG N + S + + P R+ + ++ G T+ L + G+++ WG +G+G N QP+ SRL V R+ G + A+T G+LY WG + N PVR+ A + + + A HS + A
Sbjct: 88 LLAAENGQLFAWGHNGYSQLGNGTTNQELSPVLISGHLQDKKVTKVACGSHHSMALMEDGEVFAWGYNNCGQVGSGSTANQPY-PRRITGGLQGKLAVDITCGQTSSMALVNSGEVYAWGYNGNGQLGIGNNG---NQPSP---------SRLAAFQGLCVQRIVAGYGHCLALTDEGALYAWGANTFGQLGTGNKSNHLSPVRIMAD-KERVVEVAACHSTHISA 299
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Medaka
Match: rcbtb1 (RCC1 and BTB domain-containing protein 1 [Source:NCBI gene;Acc:101165789]) HSP 1 Score: 85.8853 bits (211), Expect = 2.454e-17 Identity = 95/338 (28.11%), Postives = 147/338 (43.49%), Query Frame = 2
Query: 329 YPLYYFNDLVNFQKISIRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGLQPHSSNINGFPILMEPSEIPLPEKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVG-LGP-NKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVAC--GVKYSAAITSYGSLYVWGN 1330
+PL F+ L + + S+R+A + S G V+ G+N + LG + S I P ++ + K ++ ++ G G V++A N ++ G+N + Q G + E+ +I G DK + +V CG + L EDG V+ G N GQ+ S +ITGG++ K+ I+C + +AL GEV+ WG N N ++ P RL + + V ++ AG C L D+G L+ WG G LG NK P I A +K +VV VA SAA T G +Y+WG
Sbjct: 65 WPL--FSLLSSEDRASVRQACVFGTSANEAVYVSHGNEVFAFGLNSNGCLGTGDYCSTI-------VPKKLNFLQGKKVVS-LSYGSGPHVLLA------AENGQLFAWGHNGYSQLGNGTTNQEL--SPVLISGHLQDKKVTKVACGSHHSMALMEDGEVFAWGYNNCGQVGSGSTANQPYPRRITGGLQGKLAVDITCGQTSSMALVNSGEVYAWGYNG-NGQLGIGNNGNQPSPSRLAAFQGLC-VQRIVAGYGHCLALTDEGALYAWGANTFGQLGTGNKSNHLSPVRIMA------------DKERVVEVAACHSTHISAAKTRTGEVYMWGQ 370 HSP 2 Score: 68.1662 bits (165), Expect = 1.053e-11 Identity = 59/226 (26.11%), Postives = 100/226 (44.25%), Query Frame = 2
Query: 785 FILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMY---IVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGNDI-----VSGAYNQTFPVRMPATFHAKTLYMGADHSIIVGA 1438
+ E+G ++ G N Y QL + S + I+G +++K V +++C + +AL EDGEV+ WG N + S + + P R+ + ++ G T+ L + G+++ WG +G+G N QP+ SRL V R+ G + A+T G+LY WG + N PVR+ A + + + A HS + A
Sbjct: 146 LLAAENGQLFAWGHNGYSQLGNGTTNQELSPVLISGHLQDKKVTKVACGSHHSMALMEDGEVFAWGYNNCGQVGSGSTANQPY-PRRITGGLQGKLAVDITCGQTSSMALVNSGEVYAWGYNGNGQLGIGNNG---NQPSP---------SRLAAFQGLCVQRIVAGYGHCLALTDEGALYAWGANTFGQLGTGNKSNHLSPVRIMAD-KERVVEVAACHSTHISA 357
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Planmine SMEST
Match: SMESG000016759.1 (SMESG000016759.1) HSP 1 Score: 915.99 bits (2366), Expect = 0.000e+0 Identity = 445/448 (99.33%), Postives = 445/448 (99.33%), Query Frame = 2
Query: 104 MKRLFSKNFFNQIRSFGVKRATKDYIRNTEIYDYSTNPPKNSYLGVFGVASTGALGIKRLINNERIKNLHIARRVYPLYYFNDLVNFQKISIRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGLQPHSSNINGFPILMEPSEIPLPEKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGNDIVSGAYNQTFPVRMPATFHAKTLYMGADHSIIVGAPPA 1447
MKRLFSKNFFNQIRSFGVKRAT DYIRNTEIYDYSTNPPKNSYLGVFGVASTGALGIKRLINNERIKNLHIARRVYPLYYFNDLVNFQKISIRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGLQPHSSNINGFPILMEPSEIPLPEKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETI KVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGNDIVSGAYNQTFPV MPATFHAKTLYMGADHSIIVGAPPA
Sbjct: 1 MKRLFSKNFFNQIRSFGVKRATNDYIRNTEIYDYSTNPPKNSYLGVFGVASTGALGIKRLINNERIKNLHIARRVYPLYYFNDLVNFQKISIRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGLQPHSSNINGFPILMEPSEIPLPEKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETICKVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGNDIVSGAYNQTFPVLMPATFHAKTLYMGADHSIIVGAPPA 448
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Planmine SMEST
Match: SMESG000033544.1 (SMESG000033544.1) HSP 1 Score: 100.138 bits (248), Expect = 1.075e-22 Identity = 83/343 (24.20%), Postives = 158/343 (46.06%), Query Frame = 2
Query: 332 PLYYFNDLVNFQKISIRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGLQPHSSNINGFPILMEPSEIPLPEKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGNDIVSGAYNQT 1360
P+ F + +F++ I Y F ++ +G+ V + + + ++ I PI + + PL K ++ ++CG HS+I I ++ I ++GNN FGQC DN I +++ KF I Q++CG + +LT +G VY CG + GQ + F +I+ +K++S + +T LALTE+ ++ WGNNE+ +F + KP+ L + ++ + A + C +L ++ WG+ P + +PT I G +++D ++++++ V Y+ T G ++ GN + + Q+
Sbjct: 36 PISKFGENYDFRQYGIFDDQKDYKILNF--EAGVGYLVTALEIQKEICIFKHLFNNAIENKPISNKLTHFPL----KNVHKLSCGRDHSLIYVSIKDFSLSSLI--SMGNNTFGQCSSP--DNAIILLDNIV---KFPLVINQIQCGLDHSLVLTSNGKVYSCGLSTDGQTGLETYENVNQFTEISFEDPTIKIKKVSSQADTNLALTENNRIFCWGNNEYGQVFVNSCEIQMNKPVELTFNGST-EIKDMLALGSFCLVLTKANKVMVWGLCKNQGDPVSYI--RPTEI--QLLGVDGKIVD---EEIIQLSGSVHYAVLQTVTGRMFFIGNCPIDKCHAQS 357
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Planmine SMEST
Match: SMESG000033544.1 (SMESG000033544.1) HSP 1 Score: 85.1149 bits (209), Expect = 2.138e-18 Identity = 62/236 (26.27%), Postives = 113/236 (47.88%), Query Frame = 2
Query: 653 LGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGNDIVSGAYNQT 1360
+GNN FGQC DN I +++ KF I Q++CG + +LT +G VY CG + GQ + F +I+ +K++S + +T LALTE+ ++ WGNNE+ +F + KP+ L + ++ + A + C +L ++ WG+ P + +PT I G +++D ++++++ V Y+ T G ++ GN + + Q+
Sbjct: 1 MGNNTFGQCSSP--DNAIILLDNIV---KFPLVINQIQCGLDHSLVLTSNGKVYSCGLSTDGQTGLETYENVNQFTEISFEDPTIKIKKVSSQADTNLALTENNRIFCWGNNEYGQVFVNSCEIQMNKPVELTFNGST-EIKDMLALGSFCLVLTKANKVMVWGLCKNQGDPVSYI--RPTEI--QLLGVDGKIVD---EEIIQLSGSVHYAVLQTVTGRMFFIGNCPIDKCHAQS 223
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Planmine SMEST
Match: SMESG000033113.1 (SMESG000033113.1) HSP 1 Score: 84.7297 bits (208), Expect = 6.477e-17 Identity = 98/367 (26.70%), Postives = 154/367 (41.96%), Query Frame = 2
Query: 242 FGVASTGALGIKRLINNERIKNLHIARRVYPLYYFNDLVNFQKIS---IRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGLQPHSSNINGFPILMEPSEIPLPEKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVG-LGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAA-ITSYGSLYVWG 1327
FG AS G LGI + R K+ Y++ KIS I K + G+ TLF K+ +Y CG N +LG + N F +P++I + + K I+ + G H+ +V ++ +++T G N FG+ GR + + + + G I QV CG T LT++ ++ G+N GQL D S Q + N +K I+ LT G ++ WG+N + + D S P+ + ++ VS G A L G + TWG G LG N K I G SKV ++ CG+ ++ A + S G++Y +G
Sbjct: 139 FGAASYGQLGI-----DPRNKD-----------YYSYPQKIDKISSSDIEKISCGFDHTLFLLKNG---KLYSCGNNEFKKLG-----HDCNKF----KPNQIQMLDAHKLID-ASAGYDHNAVVTDLG-------LVFTWGKNSFGELGRDKLSDFSIKLVQSLTG----HFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRK-QPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLG----------SKVSQIECGMNHTLAYMVSTGTVYAFG 454 HSP 2 Score: 56.225 bits (134), Expect = 5.907e-8 Identity = 55/235 (23.40%), Postives = 98/235 (41.70%), Query Frame = 2
Query: 644 IYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFI--QITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYI---VGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGND 1333
I++ G +GQ G + + Y I I I ++ CG T L ++G +Y CG+N++ +L C+ F QI +K++ S + +T+ G V+ WG N + D+ + K ++ T ++QV+ G L ++ +WG +GLG N + P I + + + + G K+S +T G LY WG++
Sbjct: 136 IFSFGAASYGQLGIDPRNKDYYSYPQKIDKIS-SSDIEKISCGFDHTLFLLKNGKLYSCGNNEFKKLGHD----CNKFKPNQIQMLDAHKLIDA-SAGYDHNAVVTDLGLVFTWGKNSFGELGRDKLSDFSIKLVQ---SLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIK-----------NLSNLPIKSITAGDKFSFVLTPSGFLYSWGSN 350
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Planmine SMEST
Match: SMESG000033113.1 (SMESG000033113.1) HSP 1 Score: 84.7297 bits (208), Expect = 6.973e-17 Identity = 98/367 (26.70%), Postives = 153/367 (41.69%), Query Frame = 2
Query: 242 FGVASTGALGIKRLINNERIKNLHIARRVYPLYYFNDLVNFQKIS---IRKAATGYGFTLFSGKSSIGWHVYGCGVNHDSQLGLQPHSSNINGFPILMEPSEIPLPEKVKGINFIACGLGHSVIVAEIDAIDTNNQIIYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFIQITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYIVG-LGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAA-ITSYGSLYVWG 1327
FG AS G LGI + R K+ Y++ KIS I K + G+ TLF K+ +Y CG N +LG H N +P++I + + K I+ + G H+ +V ++ +++T G N FG+ GR + + + + G I QV CG T LT++ ++ G+N GQL D S Q + N +K I+ LT G ++ WG+N + + D S P+ + ++ VS G A L G + TWG G LG N K I G SKV ++ CG+ ++ A + S G++Y +G
Sbjct: 7 FGAASYGQLGI-----DPRNKD-----------YYSYPQKIDKISSSDIEKISCGFDHTLFLLKNG---KLYSCGNNEFKKLG---HDCN------KFKPNQIQMLDAHKLID-ASAGYDHNAVVTDLG-------LVFTWGKNSFGELGRDKLSDFSIKLVQSLTG----HFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRK-QPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLG----------SKVSQIECGMNHTLAYMVSTGTVYAFG 322 HSP 2 Score: 56.225 bits (134), Expect = 4.918e-8 Identity = 55/235 (23.40%), Postives = 98/235 (41.70%), Query Frame = 2
Query: 644 IYTLGNNKFGQCGRQIIDNEIYRGSSVIHGIKFDKPIRQVECGEVTTFILTEDGSVYGCGSNQYGQLASSDIGCCSSFI--QITGGIENKVVKQISCRCNTVLALTEDGEVWGWGNNEHNAIFSDEDHSCTFKPIRLNLPETIGKVIQVSAGSTTCAILDDKGQLHTWGMYI---VGLGPNKIVCKQPTVIPAPFFGGGSRLLDGNKSKVVRVACGVKYSAAITSYGSLYVWGND 1333
I++ G +GQ G + + Y I I I ++ CG T L ++G +Y CG+N++ +L C+ F QI +K++ S + +T+ G V+ WG N + D+ + K ++ T ++QV+ G L ++ +WG +GLG N + P I + + + + G K+S +T G LY WG++
Sbjct: 4 IFSFGAASYGQLGIDPRNKDYYSYPQKIDKIS-SSDIEKISCGFDHTLFLLKNGKLYSCGNNEFKKLGHD----CNKFKPNQIQMLDAHKLIDA-SAGYDHNAVVTDLGLVFTWGKNSFGELGRDKLSDFSIKLVQ---SLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIK-----------NLSNLPIKSITAGDKFSFVLTPSGFLYSWGSN 218 The following BLAST results are available for this feature:
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 1
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Williams-Beuren syndrome chromosomal region 16 protein isoform X1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30032953 ID=SMED30032953|Name=Williams-Beuren syndrome chromosomal region 16 protein isoform X1|organism=Schmidtea mediterranea sexual|type=transcript|length=1565bpback to top protein sequence of SMED30032953-orf-1 >SMED30032953-orf-1 ID=SMED30032953-orf-1|Name=SMED30032953-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=449bp MKRLFSKNFFNQIRSFGVKRATKDYIRNTEIYDYSTNPPKNSYLGVFGVAback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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