Integrator complex subunit 3-like protein

Overview
NameIntegrator complex subunit 3-like protein
Smed IDSMED30032950
Length (bp)1434
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Integrator complex subunit 3-like protein (SMED30032950) t-SNE clustered cells

Violin plots show distribution of expression levels for Integrator complex subunit 3-like protein (SMED30032950) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Integrator complex subunit 3-like protein (SMED30032950) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Integrator complex subunit 3-like protein (SMED30032950) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30032950

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 1

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30032950SMESG000033343.1 SMESG000033340.1 SmedASXL_017444SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Integrator complex subunit 3-like protein vs. Ensembl Human
Match: INTS3 (integrator complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:26153])

HSP 1 Score: 158.303 bits (399), Expect = 2.964e-44
Identity = 87/233 (37.34%), Postives = 129/233 (55.36%), Query Frame = 3 
Query:  405 CKQVGRDLLFTLTQVSNIPEFNKLWSEMNSSLEKLSNQYTNIGEVFSMGTNKIVIATAIPFDMENWILWTMRNVHHCSTNPYKRYQDLFNKRFFSTVESQNLRPFLIRYIIRAFYPDNEMIGSTLISRWATISWLIVQASSPTVVANCKLALIYDWLFYDKQYDCIMDIEPAILAIMHNLNSDSDISVTLVDFLVK-TANLYFPL---------------VKDQVIGCIRYGL 1055
            C  +GRDL+  L  V+ IPEF  LW ++  + + LS Q+T I ++    T++  +A  +  DME  +L+    V        KRYQD F +++ ST +SQ+LR  LIRYI    +P NE++ S ++ RWA I WL+   +S    +N KLAL YDWLF+    D IM+IEPAIL + H++     I+ TL+DF+ +   N Y PL               V+ +V+ C +Y L
Sbjct:   39 CLMIGRDLVRLLQNVARIPEFELLWKDIIHNPQALSPQFTGILQLLQSRTSRKFLACRLTPDMETKLLFMTSRVRF---GQQKRYQDWFQRQYLSTPDSQSLRCDLIRYICGVVHPSNEVLSSDILPRWAIIGWLLTTCTSNVAASNAKLALFYDWLFFSPDKDSIMNIEPAILVMHHSMKPHPAITATLLDFMCRIIPNFYPPLEGHVRQGVFSSLNHIVEKRVLACKKYWL 268
[Close]
BLAST of Integrator complex subunit 3-like protein vs. Ensembl Human
Match: INTS3 (integrator complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:26153])

HSP 1 Score: 158.303 bits (399), Expect = 2.964e-44
Identity = 87/233 (37.34%), Postives = 129/233 (55.36%), Query Frame = 3 
Query:  405 CKQVGRDLLFTLTQVSNIPEFNKLWSEMNSSLEKLSNQYTNIGEVFSMGTNKIVIATAIPFDMENWILWTMRNVHHCSTNPYKRYQDLFNKRFFSTVESQNLRPFLIRYIIRAFYPDNEMIGSTLISRWATISWLIVQASSPTVVANCKLALIYDWLFYDKQYDCIMDIEPAILAIMHNLNSDSDISVTLVDFLVK-TANLYFPL---------------VKDQVIGCIRYGL 1055
            C  +GRDL+  L  V+ IPEF  LW ++  + + LS Q+T I ++    T++  +A  +  DME  +L+    V        KRYQD F +++ ST +SQ+LR  LIRYI    +P NE++ S ++ RWA I WL+   +S    +N KLAL YDWLF+    D IM+IEPAIL + H++     I+ TL+DF+ +   N Y PL               V+ +V+ C +Y L
Sbjct:   39 CLMIGRDLVRLLQNVARIPEFELLWKDIIHNPQALSPQFTGILQLLQSRTSRKFLACRLTPDMETKLLFMTSRVRF---GQQKRYQDWFQRQYLSTPDSQSLRCDLIRYICGVVHPSNEVLSSDILPRWAIIGWLLTTCTSNVAASNAKLALFYDWLFFSPDKDSIMNIEPAILVMHHSMKPHPAITATLLDFMCRIIPNFYPPLEGHVRQGVFSSLNHIVEKRVLACKKYWL 268
[Close]
BLAST of Integrator complex subunit 3-like protein vs. Ensembl Human
Match: INTS3 (integrator complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:26153])

HSP 1 Score: 164.466 bits (415), Expect = 4.827e-43
Identity = 87/232 (37.50%), Postives = 130/232 (56.03%), Query Frame = 3 
Query:  405 CKQVGRDLLFTLTQVSNIPEFNKLWSEMNSSLEKLSNQYTNIGEVFSMGTNKIVIATAIPFDMENWILWTMRNVHHCSTNPYKRYQDLFNKRFFSTVESQNLRPFLIRYIIRAFYPDNEMIGSTLISRWATISWLIVQASSPTVVANCKLALIYDWLFYDKQYDCIMDIEPAILAIMHNLNSDSDISVTLVDFLVKTANLYFPLVKDQVIGCIRYGLNDAFRVSVFRSLAPL 1100
            C  +GRDL+  L  V+ IPEF  LW ++  + + LS Q+T I ++    T++  +A  +  DME  +L+    V        KRYQD F +++ ST +SQ+LR  LIRYI    +P NE++ S ++ RWA I WL+   +S    +N KLAL YDWLF+    D IM+IEPAIL + H++     I+ TL+DF+ +    ++P ++  V   +   LN      V   LAPL
Sbjct:   41 CLMIGRDLVRLLQNVARIPEFELLWKDIIHNPQALSPQFTGILQLLQSRTSRKFLACRLTPDMETKLLFMTSRVRF---GQQKRYQDWFQRQYLSTPDSQSLRCDLIRYICGVVHPSNEVLSSDILPRWAIIGWLLTTCTSNVAASNAKLALFYDWLFFSPDKDSIMNIEPAILVMHHSMKPHPAITATLLDFMCRIIPNFYPPLEGHVRQGVFSSLNHIVEKRVLAHLAPL 269
[Close]
BLAST of Integrator complex subunit 3-like protein vs. Ensembl Human
Match: INTS3 (integrator complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:26153])

HSP 1 Score: 164.466 bits (415), Expect = 4.827e-43
Identity = 87/232 (37.50%), Postives = 130/232 (56.03%), Query Frame = 3 
Query:  405 CKQVGRDLLFTLTQVSNIPEFNKLWSEMNSSLEKLSNQYTNIGEVFSMGTNKIVIATAIPFDMENWILWTMRNVHHCSTNPYKRYQDLFNKRFFSTVESQNLRPFLIRYIIRAFYPDNEMIGSTLISRWATISWLIVQASSPTVVANCKLALIYDWLFYDKQYDCIMDIEPAILAIMHNLNSDSDISVTLVDFLVKTANLYFPLVKDQVIGCIRYGLNDAFRVSVFRSLAPL 1100
            C  +GRDL+  L  V+ IPEF  LW ++  + + LS Q+T I ++    T++  +A  +  DME  +L+    V        KRYQD F +++ ST +SQ+LR  LIRYI    +P NE++ S ++ RWA I WL+   +S    +N KLAL YDWLF+    D IM+IEPAIL + H++     I+ TL+DF+ +    ++P ++  V   +   LN      V   LAPL
Sbjct:   41 CLMIGRDLVRLLQNVARIPEFELLWKDIIHNPQALSPQFTGILQLLQSRTSRKFLACRLTPDMETKLLFMTSRVRF---GQQKRYQDWFQRQYLSTPDSQSLRCDLIRYICGVVHPSNEVLSSDILPRWAIIGWLLTTCTSNVAASNAKLALFYDWLFFSPDKDSIMNIEPAILVMHHSMKPHPAITATLLDFMCRIIPNFYPPLEGHVRQGVFSSLNHIVEKRVLAHLAPL 269
[Close]
BLAST of Integrator complex subunit 3-like protein vs. Ensembl Human
Match: INTS3 (integrator complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:26153])

HSP 1 Score: 164.081 bits (414), Expect = 7.135e-43
Identity = 87/232 (37.50%), Postives = 130/232 (56.03%), Query Frame = 3 
Query:  405 CKQVGRDLLFTLTQVSNIPEFNKLWSEMNSSLEKLSNQYTNIGEVFSMGTNKIVIATAIPFDMENWILWTMRNVHHCSTNPYKRYQDLFNKRFFSTVESQNLRPFLIRYIIRAFYPDNEMIGSTLISRWATISWLIVQASSPTVVANCKLALIYDWLFYDKQYDCIMDIEPAILAIMHNLNSDSDISVTLVDFLVKTANLYFPLVKDQVIGCIRYGLNDAFRVSVFRSLAPL 1100
            C  +GRDL+  L  V+ IPEF  LW ++  + + LS Q+T I ++    T++  +A  +  DME  +L+    V        KRYQD F +++ ST +SQ+LR  LIRYI    +P NE++ S ++ RWA I WL+   +S    +N KLAL YDWLF+    D IM+IEPAIL + H++     I+ TL+DF+ +    ++P ++  V   +   LN      V   LAPL
Sbjct:  247 CLMIGRDLVRLLQNVARIPEFELLWKDIIHNPQALSPQFTGILQLLQSRTSRKFLACRLTPDMETKLLFMTSRVRF---GQQKRYQDWFQRQYLSTPDSQSLRCDLIRYICGVVHPSNEVLSSDILPRWAIIGWLLTTCTSNVAASNAKLALFYDWLFFSPDKDSIMNIEPAILVMHHSMKPHPAITATLLDFMCRIIPNFYPPLEGHVRQGVFSSLNHIVEKRVLAHLAPL 475
[Close]
BLAST of Integrator complex subunit 3-like protein vs. Ensembl Fly
Match: IntS3 (gene:FBgn0262117 transcript:FBtr0111268)

HSP 1 Score: 150.984 bits (380), Expect = 1.118e-38
Identity = 87/260 (33.46%), Postives = 144/260 (55.38%), Query Frame = 3 
Query:  414 VGRDLLFTLTQVSNIPEFNKLWSEMNSSLEKLSNQYTNIGEVFSMGTNKIVIATAIPFDMENWILWTMRNVHHCSTNPYKRYQDLFNKRFFSTVESQNLRPFLIRYIIRAFYPDNEMIGSTLISRWATISWLIVQASSPTVVANCKLALIYDWLFYDKQYDCIMDIEPAILAIMHNLNSDSDISVTLVDFLVKTANLYFPLVKDQVIGCIRYGLNDAFRVSVFRSLAPLHEVLRHHIELYKQFVELIGDTSNAYPHTPMN 1193
            +GRD +  L  V+ IPEF +LW ++  + + L   +  I ++  + T++  +   +  +ME  I +   +V   +    KRYQD F  ++F+T ES +LR  LIR+II   +P N+M+ S +I RWA I WLI   ++P   AN KL+L YDWLF+D   D IM+IEP IL + H++ +   +S TL+DFL +    +F   +D+    IR G+ ++ ++ + + + P  + L    +L ++   LI D    +   P N
Sbjct:  227 LGRDFVRLLQNVARIPEFEQLWRDILFNPKMLHQTFNGIWQLLHIRTSRRFLQCRLLPEMERKISFLASSVKFGNQ---KRYQDWFQDKYFATPESHSLRSDLIRFIINVIHPTNDMLCSDIIPRWAIIGWLISSCTNPIASANAKLSLFYDWLFFDPAKDNIMNIEPGILVMYHSIRNHPFVSSTLLDFLCRITKNFFVKHEDK----IRIGVYNSLKLILEKQVIPNLQPLFESPKLDRELRNLIRDNFREFLSPPAN 479
[Close]
BLAST of Integrator complex subunit 3-like protein vs. Ensembl Zebrafish
Match: ints3 (integrator complex subunit 3 [Source:NCBI gene;Acc:560575])

HSP 1 Score: 167.933 bits (424), Expect = 2.377e-44
Identity = 89/232 (38.36%), Postives = 133/232 (57.33%), Query Frame = 3 
Query:  405 CKQVGRDLLFTLTQVSNIPEFNKLWSEMNSSLEKLSNQYTNIGEVFSMGTNKIVIATAIPFDMENWILWTMRNVHHCSTNPYKRYQDLFNKRFFSTVESQNLRPFLIRYIIRAFYPDNEMIGSTLISRWATISWLIVQASSPTVVANCKLALIYDWLFYDKQYDCIMDIEPAILAIMHNLNSDSDISVTLVDFLVKTANLYFPLVKDQVIGCIRYGLNDAFRVSVFRSLAPL 1100
            C  +GRDL+  L  V+ IPE   +W ++  S + LS Q+T I ++ +  T++  +A  +  DME  +L+    V        KRYQD F +++ ST ESQ+LR  LIRYI    +P NE++ S ++ RWA I WL+   +S    +N KLAL YDWLF++ + D IM+IEPAIL + H++     I+ TL+DF+ +    +FP ++ QV   +   LN      V   LAPL
Sbjct:  224 CFIIGRDLVRLLQNVARIPEMELVWRDLLHSPQTLSPQFTGILQLLTSRTSRKFLACRLTPDMETKLLFMTSRVRF---GQQKRYQDWFQRQYLSTAESQSLRCDLIRYICGVVHPSNEVLSSDILPRWAIIGWLLTTCTSNVAASNAKLALFYDWLFFNPEKDSIMNIEPAILVMHHSMKPHPAITATLLDFMCRIIPHFFPPLEGQVRQGVFNSLNFIMEKRVLAHLAPL 452
[Close]
BLAST of Integrator complex subunit 3-like protein vs. Ensembl Mouse
Match: Ints3 (integrator complex subunit 3 [Source:MGI Symbol;Acc:MGI:2140050])

HSP 1 Score: 165.236 bits (417), Expect = 2.085e-43
Identity = 87/232 (37.50%), Postives = 131/232 (56.47%), Query Frame = 3 
Query:  405 CKQVGRDLLFTLTQVSNIPEFNKLWSEMNSSLEKLSNQYTNIGEVFSMGTNKIVIATAIPFDMENWILWTMRNVHHCSTNPYKRYQDLFNKRFFSTVESQNLRPFLIRYIIRAFYPDNEMIGSTLISRWATISWLIVQASSPTVVANCKLALIYDWLFYDKQYDCIMDIEPAILAIMHNLNSDSDISVTLVDFLVKTANLYFPLVKDQVIGCIRYGLNDAFRVSVFRSLAPL 1100
            C  +GRDL+  L  V+ IPEF  LW ++  + + LS Q+T I ++    T++  +A  +  DME  +L+    V        KRYQD F +++ ST +SQ+LR  LIRYI    +P NE++ S ++ RWA I WL+   +S    +N KLAL YDWLF+  + D IM+IEPAIL + H++     I+ TL+DF+ +    ++P ++  V   +   LN      V   LAPL
Sbjct:  246 CLMIGRDLVRLLQNVARIPEFELLWKDIIHNPQALSPQFTGILQLLQSRTSRKFLACRLTPDMETKLLFMTSRVRF---GQQKRYQDWFQRQYLSTPDSQSLRCDLIRYICGVVHPSNEVLSSDILPRWAIIGWLLTTCTSNVAASNAKLALFYDWLFFSPEKDSIMNIEPAILVMHHSMKPHPAITATLLDFMCRIIPNFYPPLEGHVRQGVFSSLNHIVEKRVLAHLAPL 474
[Close]
BLAST of Integrator complex subunit 3-like protein vs. Ensembl Mouse
Match: Ints3 (integrator complex subunit 3 [Source:MGI Symbol;Acc:MGI:2140050])

HSP 1 Score: 165.236 bits (417), Expect = 2.085e-43
Identity = 87/232 (37.50%), Postives = 131/232 (56.47%), Query Frame = 3 
Query:  405 CKQVGRDLLFTLTQVSNIPEFNKLWSEMNSSLEKLSNQYTNIGEVFSMGTNKIVIATAIPFDMENWILWTMRNVHHCSTNPYKRYQDLFNKRFFSTVESQNLRPFLIRYIIRAFYPDNEMIGSTLISRWATISWLIVQASSPTVVANCKLALIYDWLFYDKQYDCIMDIEPAILAIMHNLNSDSDISVTLVDFLVKTANLYFPLVKDQVIGCIRYGLNDAFRVSVFRSLAPL 1100
            C  +GRDL+  L  V+ IPEF  LW ++  + + LS Q+T I ++    T++  +A  +  DME  +L+    V        KRYQD F +++ ST +SQ+LR  LIRYI    +P NE++ S ++ RWA I WL+   +S    +N KLAL YDWLF+  + D IM+IEPAIL + H++     I+ TL+DF+ +    ++P ++  V   +   LN      V   LAPL
Sbjct:  246 CLMIGRDLVRLLQNVARIPEFELLWKDIIHNPQALSPQFTGILQLLQSRTSRKFLACRLTPDMETKLLFMTSRVRF---GQQKRYQDWFQRQYLSTPDSQSLRCDLIRYICGVVHPSNEVLSSDILPRWAIIGWLLTTCTSNVAASNAKLALFYDWLFFSPEKDSIMNIEPAILVMHHSMKPHPAITATLLDFMCRIIPNFYPPLEGHVRQGVFSSLNHIVEKRVLAHLAPL 474
[Close]
BLAST of Integrator complex subunit 3-like protein vs. Ensembl Mouse
Match: Ints3 (integrator complex subunit 3 [Source:MGI Symbol;Acc:MGI:2140050])

HSP 1 Score: 165.236 bits (417), Expect = 2.115e-43
Identity = 87/232 (37.50%), Postives = 131/232 (56.47%), Query Frame = 3 
Query:  405 CKQVGRDLLFTLTQVSNIPEFNKLWSEMNSSLEKLSNQYTNIGEVFSMGTNKIVIATAIPFDMENWILWTMRNVHHCSTNPYKRYQDLFNKRFFSTVESQNLRPFLIRYIIRAFYPDNEMIGSTLISRWATISWLIVQASSPTVVANCKLALIYDWLFYDKQYDCIMDIEPAILAIMHNLNSDSDISVTLVDFLVKTANLYFPLVKDQVIGCIRYGLNDAFRVSVFRSLAPL 1100
            C  +GRDL+  L  V+ IPEF  LW ++  + + LS Q+T I ++    T++  +A  +  DME  +L+    V        KRYQD F +++ ST +SQ+LR  LIRYI    +P NE++ S ++ RWA I WL+   +S    +N KLAL YDWLF+  + D IM+IEPAIL + H++     I+ TL+DF+ +    ++P ++  V   +   LN      V   LAPL
Sbjct:  246 CLMIGRDLVRLLQNVARIPEFELLWKDIIHNPQALSPQFTGILQLLQSRTSRKFLACRLTPDMETKLLFMTSRVRF---GQQKRYQDWFQRQYLSTPDSQSLRCDLIRYICGVVHPSNEVLSSDILPRWAIIGWLLTTCTSNVAASNAKLALFYDWLFFSPEKDSIMNIEPAILVMHHSMKPHPAITATLLDFMCRIIPNFYPPLEGHVRQGVFSSLNHIVEKRVLAHLAPL 474
[Close]
BLAST of Integrator complex subunit 3-like protein vs. UniProt/SwissProt
Match: sp|Q1LXC9|INT3_DANRE (Integrator complex subunit 3 OS=Danio rerio OX=7955 GN=ints3 PE=2 SV=1)

HSP 1 Score: 167.933 bits (424), Expect = 1.794e-43
Identity = 89/232 (38.36%), Postives = 133/232 (57.33%), Query Frame = 3 
Query:  405 CKQVGRDLLFTLTQVSNIPEFNKLWSEMNSSLEKLSNQYTNIGEVFSMGTNKIVIATAIPFDMENWILWTMRNVHHCSTNPYKRYQDLFNKRFFSTVESQNLRPFLIRYIIRAFYPDNEMIGSTLISRWATISWLIVQASSPTVVANCKLALIYDWLFYDKQYDCIMDIEPAILAIMHNLNSDSDISVTLVDFLVKTANLYFPLVKDQVIGCIRYGLNDAFRVSVFRSLAPL 1100
            C  +GRDL+  L  V+ IPE   +W ++  S + LS Q+T I ++ +  T++  +A  +  DME  +L+    V        KRYQD F +++ ST ESQ+LR  LIRYI    +P NE++ S ++ RWA I WL+   +S    +N KLAL YDWLF++ + D IM+IEPAIL + H++     I+ TL+DF+ +    +FP ++ QV   +   LN      V   LAPL
Sbjct:  224 CFIIGRDLVRLLQNVARIPEMELVWRDLLHSPQTLSPQFTGILQLLTSRTSRKFLACRLTPDMETKLLFMTSRVRF---GQQKRYQDWFQRQYLSTAESQSLRCDLIRYICGVVHPSNEVLSSDILPRWAIIGWLLTTCTSNVAASNAKLALFYDWLFFNPEKDSIMNIEPAILVMHHSMKPHPAITATLLDFMCRIIPHFFPPLEGQVRQGVFNSLNFIMEKRVLAHLAPL 452
[Close]
BLAST of Integrator complex subunit 3-like protein vs. UniProt/SwissProt
Match: sp|Q7TPD0|INT3_MOUSE (Integrator complex subunit 3 OS=Mus musculus OX=10090 GN=Ints3 PE=1 SV=2)

HSP 1 Score: 165.236 bits (417), Expect = 1.459e-42
Identity = 87/232 (37.50%), Postives = 131/232 (56.47%), Query Frame = 3 
Query:  405 CKQVGRDLLFTLTQVSNIPEFNKLWSEMNSSLEKLSNQYTNIGEVFSMGTNKIVIATAIPFDMENWILWTMRNVHHCSTNPYKRYQDLFNKRFFSTVESQNLRPFLIRYIIRAFYPDNEMIGSTLISRWATISWLIVQASSPTVVANCKLALIYDWLFYDKQYDCIMDIEPAILAIMHNLNSDSDISVTLVDFLVKTANLYFPLVKDQVIGCIRYGLNDAFRVSVFRSLAPL 1100
            C  +GRDL+  L  V+ IPEF  LW ++  + + LS Q+T I ++    T++  +A  +  DME  +L+    V        KRYQD F +++ ST +SQ+LR  LIRYI    +P NE++ S ++ RWA I WL+   +S    +N KLAL YDWLF+  + D IM+IEPAIL + H++     I+ TL+DF+ +    ++P ++  V   +   LN      V   LAPL
Sbjct:  246 CLMIGRDLVRLLQNVARIPEFELLWKDIIHNPQALSPQFTGILQLLQSRTSRKFLACRLTPDMETKLLFMTSRVRF---GQQKRYQDWFQRQYLSTPDSQSLRCDLIRYICGVVHPSNEVLSSDILPRWAIIGWLLTTCTSNVAASNAKLALFYDWLFFSPEKDSIMNIEPAILVMHHSMKPHPAITATLLDFMCRIIPNFYPPLEGHVRQGVFSSLNHIVEKRVLAHLAPL 474
[Close]
BLAST of Integrator complex subunit 3-like protein vs. UniProt/SwissProt
Match: sp|Q5RE70|INT3_PONAB (Integrator complex subunit 3 OS=Pongo abelii OX=9601 GN=INTS3 PE=2 SV=1)

HSP 1 Score: 164.466 bits (415), Expect = 3.181e-42
Identity = 87/232 (37.50%), Postives = 130/232 (56.03%), Query Frame = 3 
Query:  405 CKQVGRDLLFTLTQVSNIPEFNKLWSEMNSSLEKLSNQYTNIGEVFSMGTNKIVIATAIPFDMENWILWTMRNVHHCSTNPYKRYQDLFNKRFFSTVESQNLRPFLIRYIIRAFYPDNEMIGSTLISRWATISWLIVQASSPTVVANCKLALIYDWLFYDKQYDCIMDIEPAILAIMHNLNSDSDISVTLVDFLVKTANLYFPLVKDQVIGCIRYGLNDAFRVSVFRSLAPL 1100
            C  +GRDL+  L  V+ IPEF  LW ++  + + LS Q+T I ++    T++  +A  +  DME  +L+    V        KRYQD F +++ ST +SQ+LR  LIRYI    +P NE++ S ++ RWA I WL+   +S    +N KLAL YDWLF+    D IM+IEPAIL + H++     I+ TL+DF+ +    ++P ++  V   +   LN      V   LAPL
Sbjct:  248 CLMIGRDLVRLLQNVARIPEFELLWKDIIHNPQALSPQFTGILQLLQSRTSRKFLACRLTPDMETKLLFMTSRVRF---GQQKRYQDWFQRQYLSTPDSQSLRCDLIRYICGVVHPSNEVLSSDILPRWAIIGWLLTACTSNVAASNAKLALFYDWLFFSPDKDSIMNIEPAILVMHHSMKPHPAITATLLDFMCRIIPNFYPPLEGHVRQGVFSSLNHIVEKRVLAHLAPL 476
[Close]
BLAST of Integrator complex subunit 3-like protein vs. UniProt/SwissProt
Match: sp|Q68E01|INT3_HUMAN (Integrator complex subunit 3 OS=Homo sapiens OX=9606 GN=INTS3 PE=1 SV=1)

HSP 1 Score: 164.466 bits (415), Expect = 3.211e-42
Identity = 87/232 (37.50%), Postives = 130/232 (56.03%), Query Frame = 3 
Query:  405 CKQVGRDLLFTLTQVSNIPEFNKLWSEMNSSLEKLSNQYTNIGEVFSMGTNKIVIATAIPFDMENWILWTMRNVHHCSTNPYKRYQDLFNKRFFSTVESQNLRPFLIRYIIRAFYPDNEMIGSTLISRWATISWLIVQASSPTVVANCKLALIYDWLFYDKQYDCIMDIEPAILAIMHNLNSDSDISVTLVDFLVKTANLYFPLVKDQVIGCIRYGLNDAFRVSVFRSLAPL 1100
            C  +GRDL+  L  V+ IPEF  LW ++  + + LS Q+T I ++    T++  +A  +  DME  +L+    V        KRYQD F +++ ST +SQ+LR  LIRYI    +P NE++ S ++ RWA I WL+   +S    +N KLAL YDWLF+    D IM+IEPAIL + H++     I+ TL+DF+ +    ++P ++  V   +   LN      V   LAPL
Sbjct:  248 CLMIGRDLVRLLQNVARIPEFELLWKDIIHNPQALSPQFTGILQLLQSRTSRKFLACRLTPDMETKLLFMTSRVRF---GQQKRYQDWFQRQYLSTPDSQSLRCDLIRYICGVVHPSNEVLSSDILPRWAIIGWLLTTCTSNVAASNAKLALFYDWLFFSPDKDSIMNIEPAILVMHHSMKPHPAITATLLDFMCRIIPNFYPPLEGHVRQGVFSSLNHIVEKRVLAHLAPL 476
[Close]
BLAST of Integrator complex subunit 3-like protein vs. UniProt/SwissProt
Match: sp|Q7PRB8|INT3_ANOGA (Integrator complex subunit 3 homolog OS=Anopheles gambiae OX=7165 GN=AGAP002539 PE=3 SV=5)

HSP 1 Score: 158.688 bits (400), Expect = 2.283e-40
Identity = 87/245 (35.51%), Postives = 137/245 (55.92%), Query Frame = 3 
Query:  414 VGRDLLFTLTQVSNIPEFNKLWSEMNSSLEKLSNQYTNIGEVFSMGTNKIVIATAIPFDMENWILWTMRNVHHCSTNPYKRYQDLFNKRFFSTVESQNLRPFLIRYIIRAFYPDNEMIGSTLISRWATISWLIVQASSPTVVANCKLALIYDWLFYDKQYDCIMDIEPAILAIMHNLNSDSDISVTLVDFLVKTANLYFPLVKDQVIGCIRYGLNDAFRVSVFRSLAPLHEVLRHHIELYKQFVE 1148
            +GR+ +  L  V  IPEF++LW +M  + + L   +  + ++    T++  +   +  D+E  I +   NV   +    KRYQD F +R+F+T ESQ+LR  LIR+II A +P N+M+ S +I RWA I WL+   ++   +AN KLAL YDWLF+D   D IM++EP IL + H++ +   +S TL+DFL +    ++P  +D++   I   L     + V  +L PL E  +   EL     E
Sbjct:  226 LGREFVRLLQNVGRIPEFDQLWKDMLYNPKSLCPTFNGVWQLLQTRTSRRFLRGRLTPDIERKIHFLTSNVKFGNQ---KRYQDWFQERYFNTPESQSLRCDLIRFIISAIHPTNDMLCSDIIPRWAIIGWLLTSCTNAVTLANAKLALFYDWLFFDPAKDNIMNVEPGILVMYHSIKNHPLVSCTLLDFLCRIMKNFYPKWEDRIRTGIYNSLRKILEMKVIPNLVPLFESPKLDRELKGMLRE 467
[Close]
BLAST of Integrator complex subunit 3-like protein vs. TrEMBL
Match: A0A2P1E6J6 (Integrator complex subunit 3-like protein (Fragment) OS=Schmidtea mediterranea OX=79327 GN=ints3 PE=2 SV=1)

HSP 1 Score: 531.176 bits (1367), Expect = 2.123e-179
Identity = 252/272 (92.65%), Postives = 257/272 (94.49%), Query Frame = 3 
Query:  408 KQVGRDLLFTLTQVSNIPEFNKLWSEMNSSLEKLSNQYTNIGEVFSMGTNKIVIATAIPFDMENWILWTMRNVHHCSTNPYKRYQDLFNKRFFSTVESQNLRPFLIRYIIRAFYPDNEMIGSTLISRWATISWLIVQASSPTVVANCKLALIYDWLFYDKQYDCIMDIEPAILAIMHNLNSDSDISVTLVDFLVKTANLYFPLVKDQVIGCIRYGLNDAFRVSVFRSLAPLHEVLRHHIELYKQFVELIGDTSNAYPHTPMNGVTFTISVEN 1223
            KQVGRDLLFTLTQVSNIPEFNKLWSEMNSSLEKLSNQYTNIGEVFSMGTNKIVIATAIPFDMENWILWTMRNVHHCSTNPYKRYQDLFNKRFFSTVESQNLRPFLIRYIIRAFYPDNEMIGSTLISRWATISWLIVQASSPTVVANCKLALIYDWLFYDKQYDCIMDIEPAILAIMHNL   S +S+TLVDFLVKTANLYFPLVKDQ+I C R+GLNDAFRVSVFRSLAPLHEVLRHHIELYKQFVELIGDTSN YP  P+N V     VEN
Sbjct:    1 KQVGRDLLFTLTQVSNIPEFNKLWSEMNSSLEKLSNQYTNIGEVFSMGTNKIVIATAIPFDMENWILWTMRNVHHCSTNPYKRYQDLFNKRFFSTVESQNLRPFLIRYIIRAFYPDNEMIGSTLISRWATISWLIVQASSPTVVANCKLALIYDWLFYDKQYDCIMDIEPAILAIMHNLTKYSHVSITLVDFLVKTANLYFPLVKDQIISCCRFGLNDAFRVSVFRSLAPLHEVLRHHIELYKQFVELIGDTSNVYPQIPLNNVPIPKPVEN 272
[Close]
BLAST of Integrator complex subunit 3-like protein vs. TrEMBL
Match: A0A504YW20 (SOSS complex subunit A OS=Fasciola gigantica OX=46835 GN=FGIG_08409 PE=4 SV=1)

HSP 1 Score: 232.646 bits (592), Expect = 5.549e-63
Identity = 116/257 (45.14%), Postives = 168/257 (65.37%), Query Frame = 3 
Query:  393 FDECCKQVGRDLLFTLTQVSNIPEFNKLWSEMNSSLEKLSNQYTNIGEVFSMGTNKIVIATAIPFDMENWILWTMRNVHHCSTNPYKRYQDLFNKRFFSTVESQNLRPFLIRYIIRAFYPDNEMIGSTLISRWATISWLIVQASSPTVVANCKLALIYDWLFYDKQYDCIMDIEPAILAIMHNLNSDSD-ISVTLVDFLVKTANLYFPLVKDQVIGCIRYGLNDAFRVSVFRSLAPLHEVL-RHHIELYKQFVELIG 1157
            FD C  Q+GRD +  L  V+ +     LW+++ +++  L++ YT+I E+  + T +    T IP +ME W  W M+NVH     P  RYQD F ++FFST ESQ+LR  L+RYI+  FYPDNEM+ STLI RW  ISW++ Q++ P V AN KLAL YDWLF+ K  DCIM++EPA+LAIM++L   S  I+++L DFLVK A  Y+P + D++I  +R GL +  R+ V +++ PL E+L R   +L++    L+G
Sbjct:   90 FDRCA-QIGRDFVRLLHGVARLDPIKTLWNDILTNISSLTSYYTDISEILEITTPQYFTQTVIPHEMEQWARWMMKNVHCIPRVPVNRYQDFFQRKFFSTPESQSLRVNLLRYIVTFFYPDNEMLASTLIPRWNVISWILSQSTCPVVTANAKLALFYDWLFF-KPNDCIMNLEPALLAIMNHLTPRSQPIALSLTDFLVKIAASYYPPLTDRIITGVRTGLEEMIRLGVVKNINPLFEMLHRTSPDLFRSLRMLLG 344
[Close]
BLAST of Integrator complex subunit 3-like protein vs. TrEMBL
Match: A0A4E0RAK7 (Integrator complex subunit 3 OS=Fasciola hepatica OX=6192 GN=D915_006174 PE=4 SV=1)

HSP 1 Score: 231.106 bits (588), Expect = 1.831e-62
Identity = 115/257 (44.75%), Postives = 167/257 (64.98%), Query Frame = 3 
Query:  393 FDECCKQVGRDLLFTLTQVSNIPEFNKLWSEMNSSLEKLSNQYTNIGEVFSMGTNKIVIATAIPFDMENWILWTMRNVHHCSTNPYKRYQDLFNKRFFSTVESQNLRPFLIRYIIRAFYPDNEMIGSTLISRWATISWLIVQASSPTVVANCKLALIYDWLFYDKQYDCIMDIEPAILAIMHNLNSDSD-ISVTLVDFLVKTANLYFPLVKDQVIGCIRYGLNDAFRVSVFRSLAPLHEVL-RHHIELYKQFVELIG 1157
            FD C  Q+GRD +  L  V+ +     LW+++ +++  L++ Y +I E+  + T +    T IP +ME W  W M+NVH     P  RYQD F ++FFST ESQ+LR  L+RYI+  FYPDNEM+ STLI RW  ISW++ Q++ P V AN KLAL YDWLF+ K  DCIM++EPA+LAIM++L   S  I+++L DFLVK A  Y+P + D++I  +R GL +  R+ V +++ PL E+L R   +L++    L+G
Sbjct:  228 FDRCA-QIGRDFVRLLHGVARLDPIKTLWNDILTNISSLTSYYADISEILEITTPQYFTQTVIPHEMEQWARWMMKNVHCIPRVPVNRYQDFFQRKFFSTPESQSLRVNLLRYIVTFFYPDNEMLASTLIPRWNVISWILSQSTCPVVTANAKLALFYDWLFF-KPNDCIMNLEPALLAIMNHLTPRSQPIALSLTDFLVKIAASYYPPLTDRIITGVRNGLEEMIRLGVVKNINPLFEMLHRTSPDLFRSLRMLLG 482
[Close]
BLAST of Integrator complex subunit 3-like protein vs. TrEMBL
Match: A0A0V0J9L4 (Uncharacterized protein OS=Schistocephalus solidus OX=70667 GN=TR117168 PE=4 SV=1)

HSP 1 Score: 228.794 bits (582), Expect = 1.356e-61
Identity = 119/257 (46.30%), Postives = 162/257 (63.04%), Query Frame = 3 
Query:  393 FDECCKQVGRDLLFTLTQVSNIPEFNKLWSEMNSSLEKLSNQYTNIGEVFSMGTNKIVIATAIPFDMENWILWTMRNVHHCSTNPYKRYQDLFNKRFFSTVESQNLRPFLIRYIIRAFYPDNEMIGSTLISRWATISWLIVQASSPTVVANCKLALIYDWLFYDKQYDCIMDIEPAILAIMHNLNSDSD-ISVTLVDFLVKTANLYFPLVKDQVIGCIRYGLNDAFRVSVFRSLAPLHE-VLRHHIELYKQFVELIG 1157
            FD C  Q+GRDL+  L  V+    F + WS++ + L  +S  + NI  V  + T +  + T IP +ME WI W +RNVH     P +RYQ+ F+++FF T ESQ+LR  L RYI+  FYPDNEM+ S+LI RW  ISWLI Q   P    N K+AL +DWLF+ K  DCIM++EPAILAI +NL++ S   +++LVDFL K A  + P + D++   IR GL D  R+ V RSL PL + +LR   E+Y+ F  LIG
Sbjct:  236 FDRCA-QLGRDLIRMLHIVARYEPFQRFWSDILNDLPSMSCHHKNIASVLDIITPQYFVQTLIPHEMEQWIRWMLRNVHCVPPFPVRRYQEFFHRKFFLTPESQSLRVCLTRYIVNYFYPDNEMLASSLIPRWNVISWLISQCVCPIANYNIKMALFFDWLFF-KPNDCIMNVEPAILAITNNLSARSQPFALSLVDFLTKVATTFHPPLNDRISASIRAGLEDMLRLGVIRSLNPLMDFLLRAFPEVYRSFSALIG 490
[Close]
BLAST of Integrator complex subunit 3-like protein vs. TrEMBL
Match: A0A183PJ68 (Uncharacterized protein OS=Schistosoma mattheei OX=31246 GN=SMTD_LOCUS14404 PE=4 SV=1)

HSP 1 Score: 218.009 bits (554), Expect = 6.837e-61
Identity = 106/241 (43.98%), Postives = 157/241 (65.15%), Query Frame = 3 
Query:  393 FDECCKQVGRDLLFTLTQVSNIPEFNKLWSEMNSSLEKLSNQYTNIGEVFSMGTNKIVIATAIPFDMENWILWTMRNVHHCSTNPYKRYQDLFNKRFFSTVESQNLRPFLIRYIIRAFYPDNEMIGSTLISRWATISWLIVQASSPTVVANCKLALIYDWLFYDKQYDCIMDIEPAILAIMHNLNSDSD-ISVTLVDFLVKTANLYFPLVKDQVIGCIRYGLNDAFRVSVFRSLAPLHEVL 1112
            FD C  Q+GRD +  L  V+ +    +LW ++  ++  LS+ +++  E+  + T +    T IP +ME W+ W M+NVH     P  RYQD F ++FFST ESQ+LR  L+RY++  FYPDNEM+ STLI RW  +SW++ Q++ P    N KLAL YDWLF+ K  DCIM++EPA+LAIM++LN  S  I+ +LVDFL+K    Y+P + ++++  +R GL +  R+ V +S+APL E L
Sbjct:    2 FDRCA-QIGRDFIRLLHGVARLEPMKRLWDDILQNISSLSSHFSSPAEILEITTPQCFTQTLIPHEMEQWVRWMMKNVHCVPRVPVHRYQDFFQRKFFSTPESQSLRVCLLRYVVTYFYPDNEMLASTLIPRWNVVSWILSQSTCPVATVNAKLALFYDWLFF-KPNDCIMNLEPALLAIMNHLNPRSQLIAFSLVDFLIKIVGTYYPPMTERIVMGVRSGLEEMIRLGVVKSIAPLFEFL 240
[Close]
BLAST of Integrator complex subunit 3-like protein vs. Ensembl Cavefish
Match: ints3 (integrator complex subunit 3 [Source:NCBI gene;Acc:560575])

HSP 1 Score: 166.777 bits (421), Expect = 5.352e-44
Identity = 88/232 (37.93%), Postives = 133/232 (57.33%), Query Frame = 3 
Query:  405 CKQVGRDLLFTLTQVSNIPEFNKLWSEMNSSLEKLSNQYTNIGEVFSMGTNKIVIATAIPFDMENWILWTMRNVHHCSTNPYKRYQDLFNKRFFSTVESQNLRPFLIRYIIRAFYPDNEMIGSTLISRWATISWLIVQASSPTVVANCKLALIYDWLFYDKQYDCIMDIEPAILAIMHNLNSDSDISVTLVDFLVKTANLYFPLVKDQVIGCIRYGLNDAFRVSVFRSLAPL 1100
            C  +GRDL+  L  V+ IPE   LW ++  + + LS Q+T + ++ +  T++  +A  +  DME  +L+    V        KRYQD F +++ ST ESQ+LR  LIRYI    +P NE++ S ++ RWA I WL+   +S    +N KLAL YDWLF++ + D IM+IEPAIL + H++     I+ TL+DF+ +    +FP ++ QV   +   LN      V   LAPL
Sbjct:  180 CFIIGRDLVRLLQNVARIPEMELLWRDLLHNPQTLSPQFTGLLQLLTSRTSRKFLACRLTPDMETKLLFMTSRVRF---GQQKRYQDWFQRQYLSTAESQSLRCDLIRYICGVVHPSNEVLSSDILPRWAIIGWLLTTCTSNVAASNAKLALFYDWLFFNPEKDSIMNIEPAILVMHHSMKPHPAITATLLDFMCRIIPHFFPPLEGQVRQGVFNSLNFIMEKRVLAHLAPL 408
[Close]
BLAST of Integrator complex subunit 3-like protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009493.1 (pep scaffold:Pmarinus_7.0:GL478527:1630:39614:1 gene:ENSPMAG00000008569.1 transcript:ENSPMAT00000009493.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 173.326 bits (438), Expect = 5.985e-47
Identity = 102/295 (34.58%), Postives = 155/295 (52.54%), Query Frame = 3 
Query:  405 CKQVGRDLLFTLTQVSNIPEFNKLWSEMNSSLEKLSNQYTNIGEVFSMGTNKIVIATAIPFDMENWILWTMRNVHHCSTNPYKRYQDLFNKRFFSTVESQNLRPFLIRYIIRAFYPDNEMIGSTLISRWATISWLIVQASSPTVVANCKLALIYDWLFYDKQYDCIMDIEPAILAIMHNLNSDSDISVTLVDFLVKTANLYFPLVKDQVIGCIRYGLNDAFRVSVFRSLAPLHEVLRHHIELYKQFVELIGDTSNAYPHTPMNGVT---FTISVENGYHQT*GVNKKELNHSCCF 1280
            C  +GRDL+  L  V+ IPE  KLW +M  + + LS Q+T I ++  M T++  +A  +  DME  +L+ M  V        KRYQD F +++ ST +SQ+LR  LIRYI    +P NE++ S ++ RWA I WL+   +S     N KL+L YDWLF+    D IM+IEPAIL + H++     I+ TL+DF+ +    ++P ++  V   +   L       V +SL+PL +  +   EL     E   + +++ P  PM  V       ++E   H   G   K+    CCF
Sbjct:  201 CTMIGRDLVRLLQNVARIPEIEKLWRDMLHNPQSLSPQFTGILQLLQMRTSRKFLACRLTPDMETKLLFMMSKVRF---GQQKRYQDWFQRQYLSTPDSQSLRCDLIRYICGVVHPSNEVLCSDILPRWALIGWLLTTCTSNVAATNAKLSLFYDWLFFQPDKDSIMNIEPAILVMHHSMRPHPAITATLLDFMCRIMPNFYPPLESLVRQGVYSSLRSILEKRVLQSLSPLFDNPKLDRELRSMIRENFSEFTSS-PSPPMEAVKADDLPSTMEPDNHV--GERGKD---ECCF 486
[Close]
BLAST of Integrator complex subunit 3-like protein vs. Ensembl Nematostella
Match: EDO31965 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SWE7])

HSP 1 Score: 170.244 bits (430), Expect = 7.921e-46
Identity = 88/232 (37.93%), Postives = 135/232 (58.19%), Query Frame = 3 
Query:  405 CKQVGRDLLFTLTQVSNIPEFNKLWSEMNSSLEKLSNQYTNIGEVFSMGTNKIVIATAIPFDMENWILWTMRNVHHCSTNPYKRYQDLFNKRFFSTVESQNLRPFLIRYIIRAFYPDNEMIGSTLISRWATISWLIVQASSPTVVANCKLALIYDWLFYDKQYDCIMDIEPAILAIMHNLNSDSDISVTLVDFLVKTANLYFPLVKDQVIGCIRYGLNDAFRVSVFRSLAPL 1100
            C Q+GRDL+  L  V  IPEF  LW +M    + LS Q+T + ++  + T++  +A  +  +MEN +L+    V        KRYQD F++ + S+ ES++L P LIR+I+   +P NE++ S +I RWA I WL+    +    AN KLAL YDWLFY    D IM+IEPAIL + H++ S   I+ TL+DF+ +  + + P ++ +V   +R G     +  V  SL+P+
Sbjct:  212 CIQIGRDLVRLLQSVGRIPEFQALWRDMLHKPQSLSPQFTGLSQLMRIRTSRKFLACRLTPEMENKMLFLTSKVKF---GQQKRYQDWFHRMYLSSPESRSLIPDLIRFIVGVVHPSNEVLCSDIIPRWAIIGWLLTSCQTAVASANSKLALFYDWLFYQPDKDNIMNIEPAILLMHHSIKSHPAITKTLLDFICRLMSSFCPSLEKEVRQGVRNGFRTIQKKKVVMSLSPV 440
[Close]
BLAST of Integrator complex subunit 3-like protein vs. Ensembl Medaka
Match: ints3 (integrator complex subunit 3 [Source:NCBI gene;Acc:101171678])

HSP 1 Score: 166.777 bits (421), Expect = 4.500e-44
Identity = 88/232 (37.93%), Postives = 134/232 (57.76%), Query Frame = 3 
Query:  405 CKQVGRDLLFTLTQVSNIPEFNKLWSEMNSSLEKLSNQYTNIGEVFSMGTNKIVIATAIPFDMENWILWTMRNVHHCSTNPYKRYQDLFNKRFFSTVESQNLRPFLIRYIIRAFYPDNEMIGSTLISRWATISWLIVQASSPTVVANCKLALIYDWLFYDKQYDCIMDIEPAILAIMHNLNSDSDISVTLVDFLVKTANLYFPLVKDQVIGCIRYGLNDAFRVSVFRSLAPL 1100
            C+ +GRDL+  L  V+ IPE   LW ++  + + LS Q+T I ++ +  T++  +A  +  DME  +L+    V        KRYQD F +++ ST ESQ+LR  LIRYI    +P NE++ S ++ RWA I WL+   +S    +N KLAL YDWLF++ + D IM+IEPAIL + H++     I+ TL+DF+ +    ++P ++ QV   +   LN      V   LAPL
Sbjct:  224 CQIIGRDLVRLLQNVARIPEMELLWRDLLHNPQVLSPQFTGILQLLTARTSRKFLACRLTPDMETKLLFMTSRVRF---GQQKRYQDWFQRQYLSTAESQSLRCDLIRYICGVVHPSNEVLSSDILPRWAIIGWLLTTCTSNVAASNAKLALFYDWLFFNPEKDSIMNIEPAILVMHHSMKPHPAITATLLDFMCRIILHFYPPLESQVRQGVFNSLNFIMEKRVLAHLAPL 452
[Close]
BLAST of Integrator complex subunit 3-like protein vs. Planmine SMEST
Match: SMESG000033343.1 (SMESG000033343.1)

HSP 1 Score: 544.273 bits (1401), Expect = 0.000e+0
Identity = 256/277 (92.42%), Postives = 262/277 (94.58%), Query Frame = 3 
Query:  393 FDECCKQVGRDLLFTLTQVSNIPEFNKLWSEMNSSLEKLSNQYTNIGEVFSMGTNKIVIATAIPFDMENWILWTMRNVHHCSTNPYKRYQDLFNKRFFSTVESQNLRPFLIRYIIRAFYPDNEMIGSTLISRWATISWLIVQASSPTVVANCKLALIYDWLFYDKQYDCIMDIEPAILAIMHNLNSDSDISVTLVDFLVKTANLYFPLVKDQVIGCIRYGLNDAFRVSVFRSLAPLHEVLRHHIELYKQFVELIGDTSNAYPHTPMNGVTFTISVEN 1223
            FDECCKQVGRDLLFTLTQVSNIPEFNKLWSEMNSSLEKLSNQYTNIGEVFSMGTNKIVIATAIPFDMENWILWTMRNVHHCSTNPYKRYQDLFNKRFFSTVESQNLRPFLIRYIIRAFYPDNEMIGSTLISRWATISWLIVQASSPTVVANCKLALIYDWLFYDKQYDCIMDIEPAILAIMHNL   S +S+TLVDFLVKTANLYFPLVKDQ+I C R+GLNDAFRVSVFRSLAPLHEVLRHHIELYKQF+ELIGDTSN YP  P+N V     VEN
Sbjct:  215 FDECCKQVGRDLLFTLTQVSNIPEFNKLWSEMNSSLEKLSNQYTNIGEVFSMGTNKIVIATAIPFDMENWILWTMRNVHHCSTNPYKRYQDLFNKRFFSTVESQNLRPFLIRYIIRAFYPDNEMIGSTLISRWATISWLIVQASSPTVVANCKLALIYDWLFYDKQYDCIMDIEPAILAIMHNLTKYSHVSITLVDFLVKTANLYFPLVKDQIISCCRFGLNDAFRVSVFRSLAPLHEVLRHHIELYKQFLELIGDTSNVYPQIPLNNVPIPKPVEN 491
[Close]
BLAST of Integrator complex subunit 3-like protein vs. Planmine SMEST
Match: SMESG000033340.1 (SMESG000033340.1)

HSP 1 Score: 475.322 bits (1222), Expect = 1.240e-165
Identity = 226/230 (98.26%), Postives = 228/230 (99.13%), Query Frame = 3 
Query:  393 FDECCKQVGRDLLFTLTQVSNIPEFNKLWSEMNSSLEKLSNQYTNIGEVFSMGTNKIVIATAIPFDMENWILWTMRNVHHCSTNPYKRYQDLFNKRFFSTVESQNLRPFLIRYIIRAFYPDNEMIGSTLISRWATISWLIVQASSPTVVANCKLALIYDWLFYDKQYDCIMDIEPAILAIMHNLNSDSDISVTLVDFLVKTANLYFPLVKDQVIGCIRYGLNDAFRVSVF 1082
            FDECCKQVGR+LLF LTQVSNIPEFNKLWSEMNSSLEKLSNQYTNIGEVFSMGTNKIVIATAIPFDMENWILWTMRNVHHCSTNPYKRYQDLFNKRFFSTVESQNLRPFLIRYIIR F+PDNEMIGSTLISRWATISWLIVQASSPTVVANCKLALIYDWLFYDKQYDCIMDIEPAILAIMHNLNSDSDISVTLVDFLVKTANLYFPLVKDQVIGCIRYGLNDAFRVSVF
Sbjct:  215 FDECCKQVGRNLLFALTQVSNIPEFNKLWSEMNSSLEKLSNQYTNIGEVFSMGTNKIVIATAIPFDMENWILWTMRNVHHCSTNPYKRYQDLFNKRFFSTVESQNLRPFLIRYIIRVFHPDNEMIGSTLISRWATISWLIVQASSPTVVANCKLALIYDWLFYDKQYDCIMDIEPAILAIMHNLNSDSDISVTLVDFLVKTANLYFPLVKDQVIGCIRYGLNDAFRVSVF 444
The following BLAST results are available for this feature:
BLAST of Integrator complex subunit 3-like protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
INTS32.964e-4437.34integrator complex subunit 3 [Source:HGNC Symbol;A... [more]
INTS32.964e-4437.34integrator complex subunit 3 [Source:HGNC Symbol;A... [more]
INTS34.827e-4337.50integrator complex subunit 3 [Source:HGNC Symbol;A... [more]
INTS34.827e-4337.50integrator complex subunit 3 [Source:HGNC Symbol;A... [more]
INTS37.135e-4337.50integrator complex subunit 3 [Source:HGNC Symbol;A... [more]
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BLAST of Integrator complex subunit 3-like protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Integrator complex subunit 3-like protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
IntS31.118e-3833.46gene:FBgn0262117 transcript:FBtr0111268[more]
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BLAST of Integrator complex subunit 3-like protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ints32.377e-4438.36integrator complex subunit 3 [Source:NCBI gene;Acc... [more]
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BLAST of Integrator complex subunit 3-like protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Integrator complex subunit 3-like protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Ints32.085e-4337.50integrator complex subunit 3 [Source:MGI Symbol;Ac... [more]
Ints32.085e-4337.50integrator complex subunit 3 [Source:MGI Symbol;Ac... [more]
Ints32.115e-4337.50integrator complex subunit 3 [Source:MGI Symbol;Ac... [more]
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BLAST of Integrator complex subunit 3-like protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q1LXC9|INT3_DANRE1.794e-4338.36Integrator complex subunit 3 OS=Danio rerio OX=795... [more]
sp|Q7TPD0|INT3_MOUSE1.459e-4237.50Integrator complex subunit 3 OS=Mus musculus OX=10... [more]
sp|Q5RE70|INT3_PONAB3.181e-4237.50Integrator complex subunit 3 OS=Pongo abelii OX=96... [more]
sp|Q68E01|INT3_HUMAN3.211e-4237.50Integrator complex subunit 3 OS=Homo sapiens OX=96... [more]
sp|Q7PRB8|INT3_ANOGA2.283e-4035.51Integrator complex subunit 3 homolog OS=Anopheles ... [more]
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BLAST of Integrator complex subunit 3-like protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A2P1E6J62.123e-17992.65Integrator complex subunit 3-like protein (Fragmen... [more]
A0A504YW205.549e-6345.14SOSS complex subunit A OS=Fasciola gigantica OX=46... [more]
A0A4E0RAK71.831e-6244.75Integrator complex subunit 3 OS=Fasciola hepatica ... [more]
A0A0V0J9L41.356e-6146.30Uncharacterized protein OS=Schistocephalus solidus... [more]
A0A183PJ686.837e-6143.98Uncharacterized protein OS=Schistosoma mattheei OX... [more]
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BLAST of Integrator complex subunit 3-like protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ints35.352e-4437.93integrator complex subunit 3 [Source:NCBI gene;Acc... [more]
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BLAST of Integrator complex subunit 3-like protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ENSPMAT00000009493.15.985e-4734.58pep scaffold:Pmarinus_7.0:GL478527:1630:39614:1 ge... [more]
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BLAST of Integrator complex subunit 3-like protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Integrator complex subunit 3-like protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO319657.921e-4637.93Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Integrator complex subunit 3-like protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ints34.500e-4437.93integrator complex subunit 3 [Source:NCBI gene;Acc... [more]
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BLAST of Integrator complex subunit 3-like protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000033343.10.000e+092.42SMESG000033343.1[more]
SMESG000033340.11.240e-16598.26SMESG000033340.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30032950 ID=SMED30032950|Name=Integrator complex subunit 3-like protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1434bp
TATATATATATATATATATATAGTATTTACACGTTGTAAACTTTATACAT
TTTGTTTGACTGATGTGAAGTTGTACCTTGTAATTCATATATTTACCTGA
TGAACTCAGCAAACAAGTTAGTAGATGTGTGTTATTTTCTCTCACGTGAG
TTTCCTATATTCCTAAAATTATTGCCAACATTAAAGACCCTTTCAATGAA
AACCTTGAATAATAAAACGACCTGATTATTAATGGAATTAAGTTCTATAA
AATTAACTCTTAATAATCTGTATTTGAAGTTCATAAACAATTTTTCATCA
TTGATAGAATTGTCACGTTTTATAAACTTTTAATATTTTGTTTGTGATGT
TATTTTCAAATTGAAGTTTTGCCTCTGTAATTCCTGTATTAGTTTGACGA
ATGCTGTAAGCAAGTTGGGAGAGATTTGCTATTTACTCTCACACAAGTTT
CCAACATTCCTGAATTCAATAAATTATGGTCAGAAATGAACTCGAGTTTA
GAAAAACTATCAAATCAATATACTAATATCGGTGAAGTATTCAGTATGGG
TACAAATAAAATTGTCATTGCCACTGCCATTCCATTTGATATGGAGAATT
GGATCCTCTGGACTATGAGAAATGTCCATCATTGTTCCACAAATCCATAC
AAAAGATATCAAGACCTTTTTAACAAACGATTTTTTTCTACTGTCGAAAG
TCAAAACCTACGTCCCTTTTTGATTCGCTACATCATTAGAGCTTTTTACC
CTGACAATGAAATGATCGGTTCCACCTTAATATCCAGATGGGCAACAATT
TCATGGTTAATTGTCCAAGCATCTTCTCCTACAGTTGTGGCAAATTGTAA
ACTTGCCCTCATATATGATTGGCTGTTCTACGACAAACAATATGACTGTA
TCATGGACATCGAGCCAGCTATTCTTGCAATTATGCACAATTTAAATAGT
GATTCCGATATTTCTGTTACTTTGGTCGACTTCTTAGTTAAGACAGCCAA
TCTTTATTTTCCACTCGTAAAGGATCAAGTAATCGGTTGTATTCGATATG
GATTAAACGATGCATTCAGAGTTAGTGTATTCAGATCACTTGCTCCACTT
CACGAGGTCTTGAGACATCACATAGAACTTTATAAGCAGTTTGTTGAATT
AATAGGTGATACGTCCAATGCTTATCCACATACACCAATGAATGGTGTCA
CATTTACTATATCTGTAGAAAACGGATATCATCAAACATAAGGTGTCAAT
AAAAAAGAATTGAATCATTCGTGTTGTTTTATGTCTCACTATTATAATTA
TGTAACTCATGTGAGACGACAACTCACAGTTGGACGTGGATGAAATTCAA
TCTTTGCTTTATTTGCAATTACATTTTGTGTTTAGTCAATTGGATTTTCA
TTCAAATACATTTTATTATTTGTTTTAAAAAAAA
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protein sequence of SMED30032950-orf-1

>SMED30032950-orf-1 ID=SMED30032950-orf-1|Name=SMED30032950-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=252bp
MNSSLEKLSNQYTNIGEVFSMGTNKIVIATAIPFDMENWILWTMRNVHHC
STNPYKRYQDLFNKRFFSTVESQNLRPFLIRYIIRAFYPDNEMIGSTLIS
RWATISWLIVQASSPTVVANCKLALIYDWLFYDKQYDCIMDIEPAILAIM
HNLNSDSDISVTLVDFLVKTANLYFPLVKDQVIGCIRYGLNDAFRVSVFR
SLAPLHEVLRHHIELYKQFVELIGDTSNAYPHTPMNGVTFTISVENGYHQ
T*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000101muscle cell
PLANA:0002109X1 cell
PLANA:0003001lateral region of the whole animal
Vocabulary: INTERPRO
TermDefinition
IPR019333Int_cplx_su3
IPR019791Haem_peroxidase_animal
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
GO:0070876SOSS complex
Vocabulary: biological process
TermDefinition
GO:0006281DNA repair
GO:0006974cellular response to DNA damage stimulus
GO:0007093mitotic cell cycle checkpoint
GO:0010212response to ionizing radiation
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR019333Integrator complex subunit 3PFAMPF10189Ints3coord: 5..209
e-value: 2.1E-56
score: 190.8
IPR019333Integrator complex subunit 3PANTHERPTHR13587FAMILY NOT NAMEDcoord: 7..224