FMRFamide-activated amiloride-sensitive sodium channel

Query:  288 LIIKFCSNSSIRGLSRISANQNFSLKSIWLIFXXXXXXXXXXXXXXXXFEYLEYNTLINSRENHEMITIFPGITLCNHYPFHMDANKLWQSAEVLSPLKFNSIIRQMVK-DNYLKNFSLAKLLFTSDTITSYFETIGSFKAQMISHN-SSQIMYCLLLLKNSKIRVGHNNE-CGII-IKTVPNSQFLTC------QNIRIHSNYSTNAVALGLIIHMDDLSKHLNTLELGLVQDVFKQAHGLRILLHEPDTLADFSLDGFNVEPGKFTDVKFSAVKWIKINTPKEPCWSQEIIXXXXXXXXXXXXYTYDTCKNEEIGKLIYKQCNCYSSKYPLPFDIDENNVTFCSKINLSDSLEVIKRLSCLDQLESLE-----PIKQIMSENK----------------CIRRCTYMTYECHLSTAHWALSNWKL----------------YWLMTMNDALNAL--ESNKHESINSA--KSIFQQYISQSETNLSKNVTNLIKTS--------DDLFLVINRQ 1655
            +I +  S S+  GL++I  +++   K IW + +++     T+    L  +YL++  +  S     M   +P +++CN  P          S   +  + FN+  + ++    +++ F   +  F  ++I +++E +G   A+ +SHN    +M+C             N E C +    T  +  +  C      Q +++H+    N ++L   +  DD      T  +    +    + G+R+++H P ++      G ++ PG  + V   A+   ++  P   C +  +           + YT+  C      +LI ++C C SS  P   ++   N TFC  I   D  E+ +  S  D  +S E     P   +  E +                C + C+  +Y   +S ++W L  ++L                +++ T  + L  L   S KH + N +    I  +  S SE  ++K  ++LI+ +        +DL +V  RQ
Sbjct:   42 IIAELGSESNAHGLAKIVTSRDTKRKVIWALLVIAGFTAATLQLSLLVRKYLQFQVVELSEIKDSMPVQYPSVSICNIEPI---------SLRTIRRMYFNNESQNLITWLRFIQKFRFEQDSFM-NSIRAFYENLGQ-DAKKLSHNLEDMLMHCRF-----------NRELCHVSNFSTFFDGNYFNCFTFNSGQRLQMHATGPENGLSLIFSVEKDDPLP--GTYGVYNFDNNILHSAGVRVVVHAPGSMPSPVDHGIDIPPGYSSSVGLKAILHTRLPYPYGNCTNDML------NGIKQYKYTFFACLQLCKQRLIIQRCGCKSSALP---EVPSYNATFCGVIK--DWQEINRNHSNEDHNQSEEDRAFIPTPYLACEEREQKNLNNDRTYELSCGCFQPCSETSYLKSVSLSYWPLEFYQLSAVERFFKQERQAGQNHFMKTAYEYLEKLAHPSQKHLARNDSHMDDILSKSYSLSEKEMAKEASDLIRQNMLRLNIYLEDLSVVEYRQ 521          

Query:  273 QKRESLIIKFCSNSSIRGLSRISANQNFSLKSIWLIFXXXXXXXXXXXXXXXXFEYLEYNTLINSRENHEMITIFPGITLCNHYPFHMDANKLWQSAEVLSPLKFNSIIRQMVKDNYLKN-FSLAKLLFTSDTITSYFETIGSFKAQMISHNSSQIMYCLLLLKNSKIRVGHNNEC----GIIIKTVPNSQFLTCQNIRIHSNYSTNAVA-LGLIIHMDDLSKHLNTLELGLVQDVFKQAHGLRILLHEPDTLADFSLDGFNVEPGKFTDVKFSAVKWIKINTPKEPCWSQEIIXXXXXXXXXXXXYTYDTCKNEEIGKLIYKQCNCYSSKYPLP-FDIDENNVTFCSKI-NLSDSLEVIKRLSCLDQLESLEPIKQIMSENKCIRRCTYMTYECHLSTAHWALSNWKLYWLMTMNDALNA----LESNKHESINS--AKSIFQQYISQ 1577
            Q+  S  + FC  +++RGL ++     F L+ IW IF++SM  +L +  L L  ++L Y+  +++R   +  + FP +T+C+HYPF + A KLWQ  +VLSP +FN  +R +   + L N  + A+ +   D+++ Y++ +   +A+ + H+    + C+ +   + I     ++C    G  +K   + Q+L C      S+      + L LI+ M    +     E   + D+F+QA GLR+++HEP T  D    G + EPGK  ++ +  VKW K+NTP  PC+       + K  +  ++YT++ C      K I  +C CY    P P F  +E    +C K+    D+ E ++RL+C++   ++  +KQ      C  +C Y TY+  +S   W    W+LYWL     A+       E+N + SI       ++Q+Y+S+
Sbjct:   16 QRLRSAFMLFCRCTTVRGLGKLWQGPKF-LRIIWAIFVVSMMSVLIISVLFLIIDFLNYDVGVHTRLLLDEPSPFPSLTICHHYPFSLQARKLWQEKKVLSPGQFNRYMRNLTWTSLLNNDVNAAEAITFYDSLSVYYQNLKPEEARALGHDHKIFLNCMRVASQTNII---EDDCRVLSGYKVKQFSHHQYLNCHTFEPESHLEALRTSFLSLIVSMGP-KESFGPDEQAFLPDIFEQAKGLRVVVHEPGTYPDLEKFGLHAEPGKLNEIGYEPVKWTKMNTPTRPCFH---TGPQYKDLDEVYNYTHEQCILLHQQKEIIDECGCYYVMNPRPSFPTEEK--PYCGKMWPRMDTEEFVRRLNCIEAKLNIS-VKQKYDGTVCQPQCEYYTYDSTISITKWRAHPWQLYWLRVQTQAVRLAKAFAENNTNASITESLGYKMWQRYLSE 453          

Query:  225 QIVKYQNNTTVHAKKLQKRESLIIK-FCSNSSIRGLSRISANQNFSLKSIWLIFXXXXXXXXXXXXXXXXFEYLEYNTLINSRENHEMITIFPGITLCNHYPFHMDANKLWQSAE-VLSPLKFNSIIRQMVKDNYLK-NFSLAKLLFTSDTITSYFETIGSFKAQMISHNSSQ-IMYCLLLLKNSKIRVGHNNECGIIIKTVPNSQFLTCQNIR-IHSNYSTNAVALGLIIHMDDLSKHLNTLELGLVQDVFKQAHGLRILLHEPDTLADFSLDGFNVEPGKFTDVKFSAVKWIKI-NTPKEPC---WSQEIIXXXXXXXXXXXXYTYDTCKNEEIGKLIYKQCNCYSSKYPLPFDIDENNVTFCSKINLSDSLEVIKRLSCLDQL-ESLEPIKQ---------IMSENKCIRRCTYMTYECHLSTAHWALSNWKLYWLMTMNDALNALE--SNKHESINSAKSIFQQYISQSETNL--------SKNVTNLIKTSDDL--FLVINRQSFMTLEKVE 1682
            ++ +   ++++ AK + +  + I + FCS+SS+RG+ +I       L+ +WL+F+L+M +LL   S  +   Y EY+  + +       + FP IT+C+HYPF   A ++WQ  +  L+P  FN  +RQ+ +      N  LA  L   D + +Y++ +       + H+  + +++C++ + N  + VG  +EC +  + V + ++  C  ++   ++ S    A+ LI+++   S+  +  E   V DVF QA+GLR+LLHE +        G ++EPGK  ++ F  V W +  ++P + C   W   I     +   N + Y+Y  CK   + KL   +C C  S++P P  +  N + +C     S+   +  RL CL+++ E    + Q         +  +++C +RCT  +Y+  LS   W  S+++L+W++  +D+   L   +N+ E  +  ++I     + + T L         +    L  +++D   ++V+ R+SF TL++ E
Sbjct: 1300 ELTRLNADSSLPAKPVPQPSANIRQLFCSSSSLRGVPKICRADTTFLRILWLVFVLAMFILLVYSSTRVLMNYREYDVSVQTSVIGNDPSDFPAITICSHYPFSPRAARMWQQCDGQLAPATFNRRLRQLTRQLLFSGNLRLANTLLFYDKVNTYYQNLDPNVTVSMGHSVDEFLLHCMIAIGNY-VMVGKASECQLTFQLVSHPKYFNCYTVKPTQADKSQAMSAVYLIVNLGSNSRQ-HPWEQAFVMDVFDQAYGLRLLLHEANLYPGIENAGVHIEPGKMVEIAFDTVLWKETQDSPMDRCHDGWRPAI-----EDLQNRYRYSYQACKEAHMNKLFIAKCQCLLSRFPRPAGLPSNQIPYCGDFRTSNISIIESRLRCLEEIGEHQSKMPQPAAAAAAAAVADDSQCRKRCTRYSYDQELSITRWRASSYQLHWMLHQSDSWKRLREVNNESEKRHLLRNILDYLGADNLTRLPVSYQQQERQQQATLTDSAEDTYAYVVVRRKSFDTLKREE 1809          

Query:  285 SLIIKFCSNSSIRGLSRISANQNFSLKSIWLIFXXXXXXXXXXXXXXXXFEYLEYNTLINSRENHEMITIFPGITLCNHYPFHMDANKLWQSAEVLSPLKFNSIIRQMVKDNYLKN-FSLAKLLFTSDTITSYFETIGSFKAQMISHNSSQIMYCLLLLKNSKIRVGHNNEC----GIIIKTVPNSQFLTCQNIRIHSNYSTNAVA-LGLIIHMDDLSKHLNTLELGLVQDVFKQAHGLRILLHEPDTLADFSLDGFNVEPGKFTDVKFSAVKWIKINTPKEPCWSQEIIXXXXXXXXXXXXYTYDTCKNEEIGKLIYKQCNCYSSKYPLPFDIDENNVTFCSKI--NLSDSLEVIKRLSCL-DQLESLEPIKQIMSENKCIRRCTYMTYECHLSTAHWALSNWKLYWLMTMNDALNALESNKHESINSAKSI 1556
            +  + FC  +++RGL ++     F L+ IW IF++SM  +L +  + L  ++L Y+  +++R   +  + FP +T+C+HYPF M A KLWQ  +VLSP +FN  +R +   N L N  S A+ +   D+++ Y++ +   +A+ + H+    + C+ +   + I     ++C    G +++   + Q+L C              + L L++ M    +  +  E   + D+F+QA GLR+++HEP T  D    G + EPGK  ++ +  V+W K+NTP  PC+ +     K       ++YT++ C      K I + C CY    P P  +  N   +C ++  NL D  + + RL+CL D+L+    +K+      C+ RC Y TY+  +S   W    W+LYWL     A+  ++       NS K I
Sbjct:   20 TAFVLFCRCTTVRGLGKLWQGPTF-LRIIWAIFVVSMMCVLLISVVLLILDFLAYDVGVHTRLLLDDPSPFPALTVCHHYPFSMQARKLWQEKKVLSPGQFNRYMRNLTWTNLLNNDVSAAEAITFYDSLSVYYQNLSPEEAKALGHDHRIFLNCMRVSSQTSI---FEDDCRLLKGYLVRQFSHHQYLNCHTFEPADQKEALETSFLSLMVSMGP-KESSDPDEQAFLPDIFEQAKGLRVVVHEPGTYPDLEKFGLHAEPGKLNEIGYEPVRWTKMNTPTRPCFHK---AEKYHDLEGVYNYTHEQCLLLYQQKEIIEDCGCYYVMNPRP-SLPTNEKPYCGRMWPNL-DIEKFVNRLACLRDKLDIA--VKRKYDGRVCLPRCEYYTYDSAISITKWRAHMWQLYWLRVQTQAVRLVQEFTQS--NSGKDI 438          

Query:  285 SLIIKFCSNSSIRGLSRISANQNFSLKSIWLIFXXXXXXXXXXXXXXXXFEYLEYNTLINSRENHEMITIFPGITLCNHYPFHMDANKLWQSAEVLSPLKFNSIIRQMVKDNYLKN-FSLAKLLFTSDTITSYFETIGSFKAQMISHNSSQIMYCLLLLKNSKIRVGHNNEC----GIIIKTVPNSQFLTCQNIRIHSNYSTNAVA-LGLIIHMDDLSKHLNTLELGLVQDVFKQAHGLRILLHEPDTLADFSLDGFNVEPGKFTDVKFSAVKWIKINTPKEPCWSQEIIXXXXXXXXXXXXYTYDTCKNEEIGKLIYKQCNCYSSKYPLPFDIDENNVTFCSKI--NLSDSLEVIKRLSCL-DQLESLEPIKQIMSENKCIRRCTYMTYECHLSTAHWALSNWKLYWLMTMNDALNALESNKHESINSAKSI 1556
            +  + FC  +++RGL ++     F L+ IW IF++SM  +L +  + L  ++L Y+  +++R   +  + FP +T+C+HYPF M A KLWQ  +VLSP +FN  +R +   N L N  S A+ +   D+++ Y++ +   +A+ + H+    + C+ +   + I     ++C    G +++   + Q+L C              + L L++ M    +  +  E   + D+F+QA GLR+++HEP T  D    G + EPGK  ++ +  V+W K+NTP  PC+ +     K       ++YT++ C      K I + C CY    P P  +  N   +C ++  NL D  + + RL+CL D+L+    +K+      C+ RC Y TY+  +S   W    W+LYWL     A+  ++       NS K I
Sbjct:   20 TAFVLFCRCTTVRGLGKLWQGPTF-LRIIWAIFVVSMMCVLLISVVLLILDFLAYDVGVHTRLLLDDPSPFPALTVCHHYPFSMRARKLWQEKKVLSPGQFNRYMRNLTWTNLLNNDVSAAEAITFYDSLSVYYQNLSPEEAKALGHDHRIFLNCMRVSSQTSI---FEDDCRLLKGYLVRQFSHHQYLNCHTFEPADQKEALETSFLSLMVSMGP-KESSDPDEQAFLPDIFEQAKGLRVVVHEPGTYPDLEKFGLHAEPGKLNEIGYEPVRWTKMNTPTRPCFYK---AEKYHDLEGVYNYTHEQCLLLYQQKEIIEDCGCYYVMNPRP-SLPTNEKPYCGRMWPNL-DIEKFVNRLACLRDKLDIA--VKRKYDGRVCLPRCEYYTYDSAISITKWRAHMWQLYWLRVQTQAVRLVQEFTQS--NSGKDI 438          

Query:  285 SLIIKFCSNSSIRGLSRISANQNFSLKSIWLIFXXXXXXXXXXXXXXXXFEYLEYNTLINSRENHEMITIFPGITLCNHYPFHMDANKLWQSAEVLSPLKFNSIIRQMVKDNYLKN-FSLAKLLFTSDTITSYFETIGSFKAQMISHNSSQIMYCLLLLKNSKIRVGHNNEC----GIIIKTVPNSQFLTCQNIR-IHSNYSTNAVALGLIIHMDDLSKHLNTLELGLVQDVFKQAHGLRILLHEPDTLADFSLDGFNVEPGKFTDVKFSAVKWIKINTPKEPCWSQEIIXXXXXXXXXXXXYTYDTCKNEEIGKLIYKQCNCYSSKYPLPFDIDENNVTFCSKI--NLSDSLEVIKRLSCL-DQLESLEPIKQIMSENKCIRRCTYMTYECHLSTAHWALSNWKLYWLMTMNDALNA----LESNKHESINS--AKSIFQQYISQSETNLS 1595
            +  + FC  +++RGL ++     F L+ IW IF++SM  +L +  + L  ++L Y+  +++R   +  + FP +T+C+HYPF M A KLWQ  +VLSP +FN  +R +   N L N  S A+ +   D+++ Y++ +   +A+ + H+    + C+ +   + I     ++C    G  ++   + Q+L C     +    +     L LI+ M    +  +  E   + D+F+QA GLR+++HEP T  D    G + EPGK  ++ +  V+W K+NTP  PC+ +     K    +  ++YT++ C      K I + C CY    P P     N   +C ++  NL D  + + RL CL D+L     +K+    + C+ RC Y TY+  +S   W    W+LYWL     A+      ++ N   +I       ++++Y+  SE NLS
Sbjct:   20 TAFVLFCRCTTVRGLGKLWQGPTF-LRIIWAIFVVSMMCVLLISVVLLILDFLAYDVGVHTRLLLDDPSPFPALTVCHHYPFSMRARKLWQERKVLSPGRFNRYMRNLTWTNLLNNDVSAAEAITFYDSLSVYYQNLSPEEAKSLGHDHRIFLNCMRVSSQTSI---FEDDCRLLKGYRVRQFSHHQYLNCHTFEPVDQKEALETSFLSLIVSMGP-KESSDPDEQAFLPDIFEQAKGLRVVVHEPGTYPDLEKFGLHAEPGKLNEIGYQPVRWTKMNTPTRPCFHE---AEKYYDLDGIYNYTHEQCLLLYQQKEIIEDCGCYYVMNPRP-SFPTNEKPYCGRMWPNL-DIEKFVNRLECLRDKLNIA--VKRKYDGSVCLPRCEYYTYDSAISITKWRAQMWQLYWLRVQTQAVRLTQEFMQHNSSRNITESLGYRMWKRYL--SERNLS 457          

Query:  162 MTKPEKIYVRNGIIAFHTKGKQIVKYQNNTTVHAKKLQKRESLIIKFCSNSSIRGLSRISANQNFSLKSIWLIFXXXXXXXXXXXXXXXXFEYLEYNTLINSRENHEMITIFPGITLCNHYPFHMDANKLWQSAEVLSPLKFNSIIRQMVKDNYLKNFSLAKLLFTSDTITSYFETIGSFKAQMISHNSSQIMYCLLLLKNSKIRVGHNNECGIIIKTVPNSQFLTCQNIRIHSNYSTNAVALGLIIHMDDLSKHLNTLELGLVQDVFKQAHGLRILLHEPDTLADFSLDGFNVEPGKFTDVKFSAVKWIKINTPKEPCWSQEIIXXXXXXXXXXXXYTYDTCKNEEIGKLIYKQCNCYSSKYPLPFDIDENNVTFCSKINLSDSLEVIKRLSCLDQLESLEPIKQIMSENKCIRRCTYMTYECHLSTAHWALSNWKLYWLMTMNDALNALESNKHESINSAKSIFQQYISQSETNLSKNVTNLIKTSDDLFLVINRQSFMTLEKVEVFXXXXXXXXXXXXXXXXXXXXXXFTTIFEIAEFLITFFQGIQFRNIKNLRRS 1841
            MTKPEKIYVRNGIIAFHTKGKQIVKYQNNTTVHAKKLQKRESLIIKFCSNSSIRGLSRISANQNFSLKSIWLIFLLSMSVLLTVGSLSLTFEYLEYNTLINSRENHEMITIFPGITLCNHYPFHMDANKLWQSAEVLSPLKFNSIIRQMVKDNYLKNFSLAKLLFTSDTITSYFETIGSFKAQMISHNSSQIMYCLLLLKNSKIRVGH+NECGIIIKTVPNSQFLTCQNIRIHSNYSTNAVALGLIIHMDDLSKHLNTLELGLVQDVFKQAHGLRILLHEPDTLADFSLDGFNVEPGKFTDVKFSAVKWIKINTPKEPCWSQEIIKSKDKKFNNNFSYTYDTCKNEEIGKLIYKQCNCYSSKYPLPFDIDENNVTFCSKINLSDSLEVIKRLSCLDQLESLEPIKQIMSENKCIRRCTYMTYECHLSTAHWALSNWKLYWLMTMNDALNALESN HESINSAKSIFQQYISQSETNLSKNVTNLIKTSDDLFLVINRQSFMTLEKVEVFSLTRSALLSRLGGLSSITLGITFTTIFEIAEFLITFFQGIQFRNIKNLRRS
Sbjct:    1 MTKPEKIYVRNGIIAFHTKGKQIVKYQNNTTVHAKKLQKRESLIIKFCSNSSIRGLSRISANQNFSLKSIWLIFLLSMSVLLTVGSLSLTFEYLEYNTLINSRENHEMITIFPGITLCNHYPFHMDANKLWQSAEVLSPLKFNSIIRQMVKDNYLKNFSLAKLLFTSDTITSYFETIGSFKAQMISHNSSQIMYCLLLLKNSKIRVGHHNECGIIIKTVPNSQFLTCQNIRIHSNYSTNAVALGLIIHMDDLSKHLNTLELGLVQDVFKQAHGLRILLHEPDTLADFSLDGFNVEPGKFTDVKFSAVKWIKINTPKEPCWSQEIIKSKDKKFNNNFSYTYDTCKNEEIGKLIYKQCNCYSSKYPLPFDIDENNVTFCSKINLSDSLEVIKRLSCLDQLESLEPIKQIMSENKCIRRCTYMTYECHLSTAHWALSNWKLYWLMTMNDALNALESNNHESINSAKSIFQQYISQSETNLSKNVTNLIKTSDDLFLVINRQSFMTLEKVEVFSLTRSALLSRLGGLSSITLGITFTTIFEIAEFLITFFQGIQFRNIKNLRRS 560          

Query:  264 KKLQKRESLIIKFCSNSSIRGLSRISANQNFSLKSIWLIFXXXXXXXXXXXXXXXXFEYLEYNTLINSRENHEMITIFPGITLCNHYPFHMDANKLWQSAEVLSPLKFNSIIRQMVKDNYLKNFSLAKLLFTSDTITSYFETIGSFKAQMISHNSSQIMYCLLLLKNSKIRVGHNNEC----GIIIKTVPNSQFLTCQNIRIHS-NYSTNAVALGLIIHMDDLSKHLNTLELGLVQDVFKQAHGLRILLHEPDTLADFSLDGFNVEPGKFTDVKFSAVKWIKINTPKEPCW----SQEIIXXXXXXXXXXXXYTYDTCKNEEIGKLIYKQCNCYSSKYPLPFDIDENNVTFCSKINLSDSL-EVIKRLSCLDQLESLEPIKQIMSENKCIRRCTYMTYECHLSTAHWALSNWKLYWLMTMNDALNALESN-KHESINSAKSIFQQYISQ---SETNLSKNVTNLIKTSDDL-FLVINRQSFMTLEKVE 1682
            KKL K ES++  FC   +IRG++++++  +F L+ +W +F+L M+++L   +  L  +Y +Y+  ++ R+  +  T FP IT+C+H+PF  DA KLW S +VLSP  FN  +RQ       ++   A   +  D+I  Y++ +   ++  + H  + ++YCL   + +  ++   N+C      +IK + + Q   C      + + S +     LI+ +          E   + DVF+QA GLR ++HEP T+ D   +G +VEPGK  ++ F  V  +K++TPK PC     S ++I       ++ ++YT+    N E   LI K C C    YP P       V +C K+     L E   R++C+     +   ++I  E KC  RC+Y TYE  +S   W    W+L+WL   ++A  AL +N   ES  +AK+ ++ Y+ +   S  N++ +  +L    DD  ++V+ ++S +  E+ E
Sbjct:   34 KKLVKDESILELFCRCMTIRGVNKMTSASSF-LRYLWSVFVLLMTIILVGATCLLILDYFKYDVTLHQRDLQKNST-FPAITICHHHPFSKDAYKLWDSKKVLSPSLFNLYMRQNALHYLNQDDKFANNFYYFDSIDIYYQNLLYNESIALGHKYTIVLYCL---RRNDYQIDFENDCQQFDSYVIKRLSHPQHFNCYTFEPRNISVSVSTRFFSLIVSLGRPEPDYANHEQAFLIDVFEQAKGLRAVVHEPGTIPDIEREGLHVEPGKLNEINFQPVLNLKLDTPKRPCIPDNESSKLI-----DLDSKYNYTFYEYINLEKQYLIVKHCKCMYILYPRPL-YPTKEVPYCGKLWPKIDLDEFTTRINCVSNYLKMSLTEEI--EKKCRPRCSYYTYEATVSITKWRAKQWQLHWLSLQSNAQKALNANISAESYQNAKNSWKSYLERRDLSNVNIADSRKSLNLDGDDFAYVVLKKKSSILKERSE 508          

Query:  276 KRESLIIKFCSNSSIRGLSRISANQNFSLKSIWLIFXXXXXXXXXXXXXXXXFEYLEYNTLINSRENHEMITIFPGITLCNHYPFHMDANKLWQSAEVLSPLKFNSIIRQMVKDNYLKNFSL-AKLLFTSDTITSYFETIGSFKAQMISHNSSQIMYCLLLLKNSKIRVGHNNECGII----IKTVPNSQFLTCQNIRIHSNYSTNAVALGLIIHMDDLSKHLNTLELGLVQDVFKQAHGLRILLHEPDTLADFSLDGFNVEPGKFTDVKFSAVKWIKINTPKEPCWSQEIIXXXXXXXXXXXXYTYDTCKNEEIGKLIYKQCNC---YSSKYPLPFDIDENNVTFCSK-INLSDSLEVIKRLSCLDQLESLEPIKQIMSENKCIRRCTYMTYECHLSTAHWALSNWKLYWLMTMNDALNALESNKHESINSAKSI-FQQYISQSETNLSKNVTNLIKTSDD-----------LFLVINRQSFMTLEKVEVFXXXXXXXXXXXXXXXXXXXXXXFTTIFEIAEFLITFFQG 1805
            K +++ I FCS +S++G+++I+      L+ +WL F+++MS +L V S  L  +++ Y+  IN        T FP IT+C+H+PF M+A K W+  ++LSP  FN  +R +   N + N  + A+ +   D I+ Y++ IG   + +I H     + C+LL  N    + +   C  +    +K   + +   C       +  T    LG+I+ M     +  T E   + D F+QA GL++++HEP    D    G +VEPGK  ++ +  V+W   NTP +PC++ +I K +       ++YT D C + E  K I  +C+C   Y+ +  +P       + +C   +  SD  E+  R+ CL  ++     K+ +   KC +RCTYMTYE  +S   W  + W L+W+         L++N    IN+ +S  F+Q++         N TNL    +D            ++V+ R+S  ++ K E   ++   L+SR+GGL S T+GIT +   EI EFL  ++Q 
Sbjct:   74 KTKNVFILFCSTTSMKGMNKITRGPK-PLRFLWLSFVMTMSTVLIVSSCLLVRDFMLYDVNINIEVRLASQTPFPSITICHHHPFSMEAYKYWRENKILSPSTFNRKMRNLTHSNLMGNRVMEAEGISNYDVISVYYQNIGYNDSMLIGHQKDIFLSCMLLRNNM---ISYEENCSKLEEYEVKMFSHHEHFNCYTFEAKVDKIT---TLGIIVSMGPPPDYSAT-EQAFIVDTFRQAQGLKVIVHEPGVPPDIDNGGVHVEPGKLNEISYRPVEWKLENTPTKPCFN-DIKKERYNDLERFYNYTQDMCLSSEEQKRIIDECHCIFIYNPRLQIP----TKKLPYCGNFLEDSDLSELNHRIECLTNIQEDVNFKKKLESEKCFQRCTYMTYETSISITKWRATEWHLHWIRLQLLTFRQLKNNPQ--INATESTYFKQWLKYW------NATNLTVIDEDRKERFLANDNFAYIVLRRESDNSVRKYERLVISPYVLVSRIGGLCSFTVGITASFFVEILEFLYLYYQS 583          

Query:  246 NTTVHAKKLQKR---ESLIIKFCSNSSIRGLSRISANQNFSLKSIWLIFXXXXXXXXXXXXXXXXFEYLEYNTLINSRENHEMITIFPGITLCNHYPFHMDANKLWQSAEVLSPLKFNSIIRQMVKDNYLKN-FSLAKLLFTSDTITSYFETIGSFKAQMISHNSSQIMYCLLLLKNSKIRVGHNNECGII----IKTVPNSQFLTCQNIR-IHSNYSTNAVALGLIIHMDDLSKHLNTLELGLVQDVFKQAHGLRILLHEPDTLADFSLDGFNVEPGKFTDVKFSAVKWIKINTPKEPCWSQEIIXXXXXXXXXXXXYTYDTCKNEEIGKLIYKQCNCYSSKYPLPFDIDENNVTFCSKI----NLSDSLEVIKRLSCLDQLESLEPIKQIMSENKCIRRCTYMTYECHLSTAHWALSNWKLYWL----MTMNDALNALESNKHESINSAKSIFQQYISQSETNLSKNVTN----LIKTSDDLFLVINRQSFMTLEKVE 1682
            N+  H K ++K    ++  I FCS  SIRG+++I       L+ +WL F+L MS +L   S  L  +++ Y+  IN++   + +T FP +T+C+H+PF     ++W+S + +SP  FN  +R +  D  L N    A+ +   D I+ Y++ +   +A  + HNSS  + C+ LL+N +I    N  C  +    IK + + +   C        + S+N   LG+I+ +    KH + +E   + D F+QA GL++++HE  TL D    G +VEPGK  ++ +   +W   NTP +PC + +  +       N ++YT   C      + I  QC+C     P P   +E ++ +C  I    NLS+    +K   CL  + + +  +Q   + KC  RC YMT++  +S   W  + W LYWL     ++ +    L++N + ++  +++     I  ++ +L K        L+K  +  ++V+ R+S  +++K E
Sbjct:   43 NSISHGKIIKKDFQPKNFFILFCSTISIRGINKIIKGPR-PLRLLWLCFVLIMSAILITSSCLLVRDFMLYDVNINTKLEIDSMTPFPALTVCHHHPFSHRGYRMWKSGKAMSPSYFNRKMRNLTLDQLLLNDVESAETISYYDGISIYYQNLPYEQAIQMGHNSSIFLTCMYLLEN-QIYFAEN--CTKLEFYRIKLLSHHEHFNCYTFEPTQPHVSSNLDMLGIIVSLGPEPKHFD-MEQSFIIDTFRQAQGLKVIVHESGTLPDIDEAGLHVEPGKMNEIIYRPNQWQLTNTPAKPCIN-DTSRIAYVDLANTYNYTKHLCLKYAEQEDIMNQCHCMFIYNPRPMMPNE-SMPYCGSILKDFNLSNIYSYVK---CLSDVLNQKSKRQQWEKEKCFHRCNYMTFDSTISITKWRATEWHLYWLRQQITSLGEMKQFLKANPNRNVTESQAFKTWLIYGNKKDLRKTGLKANEFLLKDDNFAYIVLRRESKDSVKKYE 532          

Query:  246 NTTVHAKKLQKRESLIIKFCSNSSIRGLSRISANQNFSLKSIWLIFXXXXXXXXXXXXXXXXFEYLEYNTLINSRENHEMITIFPGITLCNHYPFHMDANKLWQSAEVLSPLKFNSIIR--------QMVKDNYLK---NFSLAKLLFT-SDTITSYFETIGSFKAQMISHNSSQIMYCLLLLKNSKIRVGHNNECGIIIKTVPNSQFLTCQNIRIHSNYSTNAVALGLIIHMDDLSKHLNTLELGLVQDVFKQAHGLRILLHEPDTLADFSLDGFNVEPGKFTDVKFSAVKWIKINTPKEPCWSQEIIXXXXXXXXXXXXYTYDTCKNEEIGKLIYKQCNCYSSKYPLPFDIDENNVTFCSKINLSDSLEVIKRLSCLDQL--ESLEPIKQIMSENKCIRRCTYMTYECHLSTAHWALSNWKLYWLMTMNDALNALESNKHESIN--------SAKSIFQQYISQSETNLS-KNVTNLIKTSDDL-------FLVINRQSFMTLEKVE 1682
            N+ +  KK ++   +I KF +N+SIRG SRI  ++   L+++W++F++S    L V    +  +Y +Y+  I +    +  T FP +T CNH PF   A +LW+ ++V+SP +FN + R         MV+        +F+    L T +D ++ Y++ + +  +  + HN S I  C+           H  +  +I+K + +  +  C  +  H  Y++    LGLII +    +       G + D+F+QA+GLR+++HEP++  +   +G  +EPG+  ++ +     IK++T ++PC ++       +  +N F Y  D C N E+ + I  +C C    YP  +      + +C  +      +++ R +C+ ++  E+ +    + ++ KCI  C+ + Y    S   W  ++W+LYWL  + DA     +    +IN        + + + Q   S+ ET  + KN++  I  S+ L       F+V+ R++  T  K E
Sbjct:    2 NSVIGNKKNKQCFEVIRKFFANTSIRGFSRIVKSETTFLRTLWILFVVSTITFLIVSIFKVVIDYRQYSVNIQTYIQIDNATPFPALTFCNHQPFSERAYQLWEESKVMSPTQFNELFRSEALKQFKDMVRTKMTPKDSDFNHPLFLTTINDRLSVYYQNLPTTVSSELGHNISIIKNCVWSYGQHMAFDNHCQDDMLIVKNISHPSYFNCFTVEPHPKYASIFSRLGLIIWLGPDEQTNIKHRQGFLFDIFEQAYGLRVIIHEPNSYPNIESEGVQIEPGRLNELNYQPELNIKVDTERKPCINEP--DRIYRDLDNVFKYDIDLCFNMELQQRIITECKCIYGYYPR-YLHPSKELPYCGYLEPEKYHDLLFRKNCITKIFNEAPDIKSNLKADKKCIHSCSSIEYTTTTSVTKWRPTDWQLYWLKEVLDAWAQYYNLMARNINIPSNNMTTTDRIMLQNLTSRIETFFTRKNLSEFIPESEKLLFNERYTFVVVKRKANNTFIKEE 507