Neurotrypsin
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30032823 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 51Note: Hover over icons to view figure legend
Homology
BLAST of Neurotrypsin vs. Ensembl Human
Match: PRSS12 (serine protease 12 [Source:HGNC Symbol;Acc:HGNC:9477]) HSP 1 Score: 303.908 bits (777), Expect = 8.077e-86 Identity = 199/551 (36.12%), Postives = 285/551 (51.72%), Query Frame = 1 Query: 2101 NCGDNSDE-IDCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDSH-WCGASILSEDWIIGAAHCYAR---PKSDYRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPN-SKCLVSGWGDTLSTYPEKLLAAEVPLIKHERCFEFYKGRLTERMQCAG--YEAGGIDTCQGDSGGPLVCKVNG-VYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQTGL 3726 NCG D + CT +T IRL G +EG++EV Y+G+WG VCDDG+ VVC+QLGF ++ + N F ++ P + +D++ C+G E +C W H+C E D + C G + V L DG + K GRVE+ G GT+CDD + DKDAAVICR L G A+A FGEG G I +DN+KCTG E +L +C G H C H ED GVIC D + + K ++ CG R + ++ R++GG ++ G +PWQV +R K D CGA++LS W++ AAHC+ R Y VR GD+ +++E+ ++++++H + DYD AL++++ + +F+++V P CLP P S C ++GWGDT Y L A +PL+ C E YKGR T RM CAG +E +D+CQGDSGGPL+C+ G + ++G TSWG GC +PGVY K+ + WIK T L Sbjct: 368 NCGHKEDAGVSCTPLT--DGVIRLAGGKGSHEGRLEVYYRGQWGTVCDDGWTELNTYVVCRQLGFKYGKQA---SANHFEESTGP-IWLDDVSCSGKETRFLQCSRRQWGRHDCSHRE--------------------------------DVSIACYPGGEGHRLSLGFPVRLMDGENKKEGRVEVFINGQWGTICDDGWTDKDAAVICRQLGYKGPARARTMAYFGEGKGPIHVDNVKCTGNERSLADCIKQDIGRHNCRHSEDAGVIC---DYFGKKASGNSNKESLSS--VCGLRLLHRRQKRIIGGKNSLRGGWPWQVSLRLKSSHGDGRLLCGATLLSSCWVLTAAHCFKRYGNSTRSYAVRVGDYHTLVPEEFEEEIGVQQIVIHREYRPDRSDYDIALVRLQGPEEQCARFSSHVLPACLPLWRERPQKTASNCYITGWGDTGRAYSRTLQQAAIPLLPKRFCEERYKGRFTGRMLCAGNLHEHKRVDSCQGDSGGPLMCERPGESWVVYGVTSWGYGCGVKDSPGVYTKVSAFVPWIKSVTKL 875 HSP 2 Score: 140.969 bits (354), Expect = 7.255e-33 Identity = 90/262 (34.35%), Postives = 130/262 (49.62%), Query Frame = 1 Query: 2125 IDCTTVTFPPFEI-RLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVIC 2907 + C+ P F I RL G + +EG+VE+ + G+WG VCDD +D AEV+C+QLG G ++ H A FG+ P +++DE++CTG E S+E+C S W HNC E AGV C +DG + LA G + GR+E+ G GTVCDD + + + V+CR L QA + F E G I LD++ C+G+E C +WG H C+H+ED+ + C Sbjct: 267 VTCSFSHGPTFPIIRLAGGSSVHEGRVELYHAGQWGTVCDDQWDDADAEVICRQLGLSGIAKAWHQAY--FGEGSGP-VMLDEVRCTGNELSIEQCPKSSWGEHNCGHKEDAGVSC-----------------------------TPLTDGV----------IRLAGGKGSHEGRLEVYYRGQWGTVCDDGWTELNTYVVCRQLGFKYGKQASAN-HFEESTGPIWLDDVSCSGKETRFLQCSRRQWGRHDCSHREDVSIAC 485 HSP 3 Score: 129.028 bits (323), Expect = 4.306e-29 Identity = 93/275 (33.82%), Postives = 121/275 (44.00%), Query Frame = 1 Query: 2107 GDNSDEIDCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICG-LPDEVV 2928 GD ++D +RL G N++EG VEV G WG VC +D A V+C QL G + + + G + ++C G E ++ C+ W+ C A V C T R LA G GRVEL G GTVCDD +DD DA VICR L + G A+A FGEG+G ++LD ++CTG EL++E CP WGEH C HKED GV C L D V+ Sbjct: 152 GDARGKVDWGYCDCRHGSVRLRGGKNEFEGTVEVYASGVWGTVCSSHWDDSDASVICHQLQLGGKGIAKQTPFSGLGLI---PIYWSNVRCRGDEENILLCEKDIWQGGVCPQKMAAAVTCSFSHGPTFPIIR------------------------------------LAGGSSVHEGRVELYHAGQWGTVCDDQWDDADAEVICRQLGLSGIAKAWHQAYFGEGSGPVMLDEVRCTGNELSIEQCPKSSWGEHNCGHKEDAGVSCTPLTDGVI 387 HSP 4 Score: 70.8626 bits (172), Expect = 3.189e-11 Identity = 48/109 (44.04%), Postives = 62/109 (56.88%), Query Frame = 1 Query: 358 IIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPHDS--TSYCSGKS-AGVSC 675 IIRL G +++ +EGRVE+Y + WG VCDD W+ DA V CRQLG A+ A Q +G G V + +++CTGNE S+ CP S C K AGVSC Sbjct: 279 IIRLAGGSSV--HEGRVELYHAGQ--WGTVCDDQWDDADAEVICRQLGLSGIAK-AWHQAYFGEGSGPV---MLDEVRCTGNELSIEQCPKSSWGEHNCGHKEDAGVSC 379 HSP 5 Score: 65.0846 bits (157), Expect = 1.798e-9 Identity = 38/86 (44.19%), Postives = 50/86 (58.14%), Query Frame = 1 Query: 367 LRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDC 624 + GEN EGRVEV+ + WG +CDD W DA V CRQLG++ AR T +G G ++ V ++CTGNE+SL DC Sbjct: 503 MDGENK---KEGRVEVFINGQ--WGTICDDGWTDKDAAVICRQLGYKGPARART-MAYFGEGKGPIH---VDNVKCTGNERSLADC 579 HSP 6 Score: 53.1434 bits (126), Expect = 8.528e-6 Identity = 32/94 (34.04%), Postives = 46/94 (48.94%), Query Frame = 1 Query: 343 PESPQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDC 624 P + +IRL G ++EGR+EVY WG VCDD W L+ V CRQLGF+ + + G ++D + C+G E + C Sbjct: 381 PLTDGVIRLAGGKG--SHEGRLEVYYRGQ--WGTVCDDGWTELNTYVVCRQLGFKYGKQASANHFEESTGPIWLDD-----VSCSGKETRFLQC 465
BLAST of Neurotrypsin vs. Ensembl Human
Match: TMPRSS2 (transmembrane serine protease 2 [Source:HGNC Symbol;Acc:HGNC:11876]) HSP 1 Score: 173.711 bits (439), Expect = 3.480e-45 Identity = 137/432 (31.71%), Postives = 212/432 (49.07%), Query Frame = 1 Query: 2455 AGVVCK-VDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLE--NCPFFKWGEHK--CTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDSHWCGASILSEDWIIGAAHCYARPKSD--YRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPNSKCLVSGWGDT--LSTYPEKLLAAEVPLIKHERCFE--FYKGRLTERMQCAGYEAGGIDTCQGDSGGPLVCKVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQ 3717 AG++ K + C+NS C CI+ S CD + C G DE +C V++ GP+ +V S+ VC DD+++ CR + K+ + + IV D+ + +LN N +K H C+ K + + C + CG ++ R+VGG A+ GA+PWQV + + + H CG SI++ +WI+ AAHC +P ++ + S Y +++E++I HPN+++ + D AL+K+++ + FN+ V+PVCLP GM+ P C +SGWG T E L AA+V LI+ +RC Y +T M CAG+ G +D+CQGDSGGPLV N ++ + G TSWG+GCA+ PGVY + + DWI Q Sbjct: 102 AGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDE--NRC-VRLY---GPNFIL-QVYSSQRKSWHPVCQDDWNENYGRAACRDM-------GYKNNFYS--SQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRC----------------------IACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQ----NVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQK----PLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQ 487
BLAST of Neurotrypsin vs. Ensembl Human
Match: TMPRSS2 (transmembrane serine protease 2 [Source:HGNC Symbol;Acc:HGNC:11876]) HSP 1 Score: 173.711 bits (439), Expect = 3.480e-45 Identity = 137/432 (31.71%), Postives = 212/432 (49.07%), Query Frame = 1 Query: 2455 AGVVCK-VDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLE--NCPFFKWGEHK--CTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDSHWCGASILSEDWIIGAAHCYARPKSD--YRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPNSKCLVSGWGDT--LSTYPEKLLAAEVPLIKHERCFE--FYKGRLTERMQCAGYEAGGIDTCQGDSGGPLVCKVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQ 3717 AG++ K + C+NS C CI+ S CD + C G DE +C V++ GP+ +V S+ VC DD+++ CR + K+ + + IV D+ + +LN N +K H C+ K + + C + CG ++ R+VGG A+ GA+PWQV + + + H CG SI++ +WI+ AAHC +P ++ + S Y +++E++I HPN+++ + D AL+K+++ + FN+ V+PVCLP GM+ P C +SGWG T E L AA+V LI+ +RC Y +T M CAG+ G +D+CQGDSGGPLV N ++ + G TSWG+GCA+ PGVY + + DWI Q Sbjct: 102 AGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDE--NRC-VRLY---GPNFIL-QVYSSQRKSWHPVCQDDWNENYGRAACRDM-------GYKNNFYS--SQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRC----------------------IACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQ----NVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQK----PLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQ 487
BLAST of Neurotrypsin vs. Ensembl Human
Match: TMPRSS2 (transmembrane serine protease 2 [Source:HGNC Symbol;Acc:HGNC:11876]) HSP 1 Score: 173.711 bits (439), Expect = 3.533e-45 Identity = 137/432 (31.71%), Postives = 212/432 (49.07%), Query Frame = 1 Query: 2455 AGVVCK-VDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLE--NCPFFKWGEHK--CTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDSHWCGASILSEDWIIGAAHCYARPKSD--YRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPNSKCLVSGWGDT--LSTYPEKLLAAEVPLIKHERCFE--FYKGRLTERMQCAGYEAGGIDTCQGDSGGPLVCKVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQ 3717 AG++ K + C+NS C CI+ S CD + C G DE +C V++ GP+ +V S+ VC DD+++ CR + K+ + + IV D+ + +LN N +K H C+ K + + C + CG ++ R+VGG A+ GA+PWQV + + + H CG SI++ +WI+ AAHC +P ++ + S Y +++E++I HPN+++ + D AL+K+++ + FN+ V+PVCLP GM+ P C +SGWG T E L AA+V LI+ +RC Y +T M CAG+ G +D+CQGDSGGPLV N ++ + G TSWG+GCA+ PGVY + + DWI Q Sbjct: 102 AGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDE--NRC-VRLY---GPNFIL-QVYSSQRKSWHPVCQDDWNENYGRAACRDM-------GYKNNFYS--SQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRC----------------------IACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQ----NVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQK----PLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQ 487
BLAST of Neurotrypsin vs. Ensembl Human
Match: TMPRSS2 (transmembrane serine protease 2 [Source:HGNC Symbol;Acc:HGNC:11876]) HSP 1 Score: 174.096 bits (440), Expect = 6.487e-45 Identity = 137/432 (31.71%), Postives = 212/432 (49.07%), Query Frame = 1 Query: 2455 AGVVCK-VDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLE--NCPFFKWGEHK--CTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDSHWCGASILSEDWIIGAAHCYARPKSD--YRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPNSKCLVSGWGDT--LSTYPEKLLAAEVPLIKHERCFE--FYKGRLTERMQCAGYEAGGIDTCQGDSGGPLVCKVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQ 3717 AG++ K + C+NS C CI+ S CD + C G DE +C V++ GP+ +V S+ VC DD+++ CR + K+ + + IV D+ + +LN N +K H C+ K + + C + CG ++ R+VGG A+ GA+PWQV + + + H CG SI++ +WI+ AAHC +P ++ + S Y +++E++I HPN+++ + D AL+K+++ + FN+ V+PVCLP GM+ P C +SGWG T E L AA+V LI+ +RC Y +T M CAG+ G +D+CQGDSGGPLV N ++ + G TSWG+GCA+ PGVY + + DWI Q Sbjct: 139 AGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDE--NRC-VRLY---GPNFIL-QVYSSQRKSWHPVCQDDWNENYGRAACRDM-------GYKNNFYS--SQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRC----------------------IACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQ----NVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQK----PLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQ 524
BLAST of Neurotrypsin vs. Ensembl Celegans
Match: svh-1 (HGF/MSP/plasminogen-like protein [Source:UniProtKB/TrEMBL;Acc:Q17800]) HSP 1 Score: 196.823 bits (499), Expect = 1.217e-50 Identity = 141/435 (32.41%), Postives = 199/435 (45.75%), Query Frame = 1 Query: 2425 RSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLE-NCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDSHWCGASILSEDWIIGAAHCYARPK--SDYRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPNSKCLVSGWGDTLSTYPEKLLAAEVPLIKHERCFEFYK--GRLTERMQCAGYEAGGIDTCQGDSGGPLVCKV-NGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIK 3711 R NC I+ C+ R C++ + D CI ++C+ DC G DE + L +G D SG +E+ +C D + K + IC + R GE + + +G +N + +C + CT I I +Q +V+ K + RVVGGFE V GAFPW +R K +H CGASIL + +I AAHC+ + S Y V GDWDN D EQ+F ++ + +P + + I I GI+FN Y QP+CLP V P +C+VSGWG Y E+L AA +P+I C + ++ CAGY GGID+CQGDSGGP C+ +G + + G SWG+GCAQ K PG+Y + L WI Sbjct: 541 REPNCTSTVIS--TCEPIR-CSHCQQAACGDGSCIRFDQLCNGQIDCQSGEDEDYCRAN-SFRLTNGSDT-SGYLEVLFRSRWEPICADHLNGKISNSICDAM------------RLGEHGFILSTNATISSGYNVNCDVDCSIRR--SSSCTRHARISCISQNGMSSASQCGLRYVEVNARDAAK-------SRIARVVGGFETVPGAFPWTAALRNKATK--AHHCGASILDKTHLITAAHCFEEDERVSSYEVVVGDWDNNQTDGNEQIFYLQRIHFYPLYKDIFSHD----IAILEIPYPGIEFNEYAQPICLPSKDFVYTPGRQCVVSGWGSMGLRYAERLQAALIPIINRFDCVNSSQIYSSMSRSAFCAGYLEGGIDSCQGDSGGPFACRREDGAFVLAGVISWGDGCAQKKQPGIYTMVAPYLSWIS 943
BLAST of Neurotrypsin vs. Ensembl Celegans
Match: try-1 (TRYpsin-like protease [Source:UniProtKB/TrEMBL;Acc:Q23528]) HSP 1 Score: 128.257 bits (321), Expect = 5.459e-32 Identity = 84/243 (34.57%), Postives = 122/243 (50.21%), Query Frame = 1 Query: 3013 RVVGGFEAVYGAFPWQVGVRQKVDDYDSHWCGASILSEDWIIGAAHCYA--RPKSDYRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPNSKCLVSGWGDTL---STYPEKLLAAEVPLIKHERCFEF--YKGRL-TERMQCAGYEAGGIDTCQGDSGGPLVCKVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQ 3717 R++GG E+ ++PW V Q + H CG S++ ++++ AAHC+A R + Y VR G + S + + + +HP W N + Y + + V + +P+CLP L V N C+V+GWG T+ S L VPL+ C Y GR+ M CAGY G ID+CQGDSGGPL+C +G + + G SWG GCA+P PGVY + WI + Sbjct: 57 RLIGGSESSPHSWPWTV---QLLSRLGHHRCGGSLIDPNFVLTAAHCFAKDRRPTSYSVRVGGHRSGSGSPHR----VTAVSIHP-WYNIGFPSSYDFAIMRIHPPVNT--STTARPICLPSLPAVE--NRLCVVTGWGSTIEGSSLSAPTLREIHVPLLSTLFCSSLPNYIGRIHLPSMLCAGYSYGKIDSCQGDSGGPLMCARDGHWELTGVVSWGIGCARPGMPGVYGNVHSASTWINLE 287
BLAST of Neurotrypsin vs. Ensembl Celegans
Match: try-3 (TRYpsin-like protease [Source:UniProtKB/TrEMBL;Acc:Q94176]) HSP 1 Score: 72.4034 bits (176), Expect = 7.117e-13 Identity = 82/273 (30.04%), Postives = 127/273 (46.52%), Query Frame = 1 Query: 2986 HRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDSHWCGASILSEDWIIGAAHCYARPKSDYRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERN-DGVGIKFNNYVQPVCLPKLGMVPDPNSKCL-------VSGWGDTLS---------TYPEKLLAAEVPLIKHERCFEFYKGRLTERMQCAGYE--AGGI--DTCQGDSGGPLVC-KVNGVYTIFGATSWG----NGCA-QPKNPGVYAKIQMQLDWIKEQTG 3723 ++PI R++GG GA W + D+ CGA+++ + W++ AAHC + ++ R+ + + E+ F ++E +H +NN D D AL++I + +GIK PVCL V D +SK L V G+G TL + L + VP+I + C + ++ ++ GY+ AG T GDSGGPL+ K NG Y G TS+G +G Q K PGVY +I + WI+ G Sbjct: 30 YKPIF--SFRIIGGNSIDDGA-NWMAKLVSYGDNGQGILCGATVIDDFWLVTAAHCALQLQT----RSFVYVREPKNNRERSFSVKEAYIHSGYNNQTADNDIALLRISSDLSKLGIK------PVCL-----VHD-DSKLLKQYKNGVVIGYGLTLGEDSSGEPKLINSQTLQSTSVPIISDDDCVKTWRFLSLLSVKITGYQICAGAYLHGTAPGDSGGPLLIHKSNGEYVQIGITSYGADGLDGVIDQGKFPGVYTRISKYVPWIQGVIG 283
BLAST of Neurotrypsin vs. Ensembl Celegans
Match: lrp-2 (Low-density lipoprotein RecePtor related [Source:UniProtKB/TrEMBL;Acc:O01768]) HSP 1 Score: 74.3294 bits (181), Expect = 1.347e-12 Identity = 57/197 (28.93%), Postives = 83/197 (42.13%), Query Frame = 1 Query: 1546 QCIPKNEVCDKIPHCLGKEDEDHGFCKKYLCKENEFFCASDMFCILKTHVCDGKRNCADGSDEKNCTVLD-ESALLKVYDKTDSKILDVSDKLDYIDIPIDKCAEKCKILFHQFACKSFNYLPPHESRTHSECRLLTKLASEEPYKLIAITYPGAHYSMKSDCTAEQFKCTRGMCIELSKKCDHRDNCGDNSDEIDC 2133 QC+ +++CD + C G +DE+ FC+ + C E +F C CI T VCD +++C DGSDE NC + + ++ T I KC K +F C + P + +EP I +CT EQF+CT G CI ++CD +C D SDE C Sbjct: 3544 QCLYASKLCDGVKDCSGGDDEEPAFCENFECTEAQFKCGDKKKCIPLTSVCDKEKDCDDGSDELNCEITSCKPDFFACFNGT----------------AISKCIPK------EFYCDGEDDCPEGQ---------------DEPDSCFGI----------GECTHEQFQCTSGKCIPKRRQCDGTLDCRDGSDEKGC 3693 HSP 2 Score: 63.5438 bits (153), Expect = 2.328e-9 Identity = 97/396 (24.49%), Postives = 146/396 (36.87%), Query Frame = 1 Query: 1537 YNRQCIPKNEVCDKIPHCLGKEDEDHGFCKKYLCKENEFFCASDMFCILKTHVCDGKRNCADGSDEKNCTVLDESALLKVYDKTDSK-----ILDVSDKLDYIDIPIDKCAEKCKILFHQFACKSFNYLPPHESRTHSECRLLT---------KLASEEPYKLIAITYPGAHYSMKSDCTAE-QFKC--TRGMCIELSKKCDHRDNCGDNSDEIDCTTVTFPPFEIRLTGSVN--KYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAME-SIHSAVNRFGK--------NRSPNLLVDEIKCTGTENSLEECKHSPWRSHN---CRPDEIAGVVC----------------KVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDE 2583 ++ +CI + CD+ C +DED +C +C+ F C + + CI + VC+ +CA+ +DE NCT + + SK + D +D D I P C+ A F T S+C + S+E + G S C A+ QF C TR C+ +CD + +C D SDE +C FE S E K + R C DG D E C G + H + + + + +L DE+ C S H P R + E+ V+C +DR C +E+ C + CI ++CD + DC DGSDE Sbjct: 2648 HSDRCIRYEDTCDRYNDCPMFDDEDTKYCSTRVCRPGYFNCGNGL-CIPEQKVCNRINDCANFADESNCTCNENEFRCQSGACIPSKARCNHMQDCNDASDEIGCPFRNCS----------ALNEFGMTGLINCATTSQCIHPSWKCDGTNDCYDGSDEKDCFVEFDATGGSVSAPRSCDAKTQFACLATR-TCMPKHWQCDGQPDCADGSDEKNCDAKKCTSFEFSCESSKKCIPLEQKCDGRRD------CPDGEDEHQCETECDSKGGNATFRCTNHRCIPMAWRCDGTDDCMDNAKSLGSDEVDCAAGRTSF----HVPSRCADETCVVACELTAVLCDGIQDCSDGFDEKNCASLDRQCKPNEWMCDSGQ-CIDSGRLCDASVDCVDGSDE 3020 HSP 3 Score: 57.3806 bits (137), Expect = 1.791e-7 Identity = 58/217 (26.73%), Postives = 89/217 (41.01%), Query Frame = 1 Query: 1543 RQCIPKNEVCDKIPHCLGKEDEDHGFCKKYLCKENEFFCASDMFCILKTHVCDGKRNCADGSDEKNC-TVLDESALLKVYDKTDSKILDVSDKLDYIDIPIDKCAEKCKILFHQFACKSFNYLPPHESRTHSECRLLTKLASEEPYKLIAITYPGAH-----------YSMKSDCTAEQFKCTRGMCIELSKKCDHRDNCGDNSDE-IDCTTVTFPP 2154 R C+PK+ CD P C DE + C C EF C S CI CDG+R+C DG DE C T D + T+ + + ++ + D D +D A ++ ++P S C T + + E L A+ G S+ C ++ C G CI+ + CD +C D SDE ++ +++ PP Sbjct: 2827 RTCMPKHWQCDGQPDCADGSDEKN--CDAKKCTSFEFSCESSKKCIPLEQKCDGRRDCPDGEDEHQCETECDSKGGNATFRCTNHRCIPMAWRCDGTDDCMDNAKSLGSDEVDCAAGRTSFHVP-------SRCADETCVVACE---LTAVLCDGIQDCSDGFDEKNCASLDRQCKPNEWMCDSGQCIDSGRLCDASVDCVDGSDEWVEICSLSEPP 3031 HSP 4 Score: 52.7582 bits (125), Expect = 4.634e-6 Identity = 65/247 (26.32%), Postives = 100/247 (40.49%), Query Frame = 1 Query: 1498 CQSIQYHCPSMISYNRQCIPKNEVCDKIPHCLGKEDEDHGFC-KKYLCKENEFFCASDMFCILKTHVCDGKRNCADGSDEKNCTVLDESALLKVYDKTDSK--ILDVSDKLDYI---DIPIDKCAEKCK-------ILFHQFACKSFNYLPPHESRTHSECRLLTKLASEEPYKLIAITYPGAHYSMKSDCTAEQFKCTRGM-CIELSKKCDHRDNCGDNSDEIDCTTVTFPPFEIRLTGSVNKYEG 2196 C Q+ C +CI K++ C+ + C DE+ C + LC +EF C + + CI ++ VCDGK C DG DE++C ++ + + + K LD+ + D + + D+ E CK +QF C +C +L P L SM T C G CI +CD D+CGDNSDE CT + +R + + +G Sbjct: 1013 CSVSQFQCSKT-----KCIIKSKRCNGVQECDNGADEED--CPRSKLCDPDEFRCGTGL-CIKQSQVCDGKMQCLDGLDEEHCNEEEKCLQGRQFRCANGKSTCLDLIFRCDGVADCEDSSDESDEFCKGNSSSTCGKMNQFMC------------ADGKCLRSFQLCDGFPDCLTGEDETECPPSMCDSTT--HLSCLNGQKCISKQLECDGVDDCGDNSDEKHCTEIRLDEAALRCQSPMYQCDG 1237
BLAST of Neurotrypsin vs. Ensembl Celegans
Match: try-3 (TRYpsin-like protease [Source:UniProtKB/TrEMBL;Acc:Q94176]) HSP 1 Score: 69.3218 bits (168), Expect = 3.268e-12 Identity = 73/234 (31.20%), Postives = 112/234 (47.86%), Query Frame = 1 Query: 3103 CGASILSEDWIIGAAHCYARPKSDYRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERN-DGVGIKFNNYVQPVCLPKLGMVPDPNSKCL-------VSGWGDTLS---------TYPEKLLAAEVPLIKHERCFEFYKGRLTERMQCAGYE--AGGI--DTCQGDSGGPLVC-KVNGVYTIFGATSWG----NGCA-QPKNPGVYAKIQMQLDWIKEQTG 3723 CGA+++ + W++ AAHC + ++ R+ + + E+ F ++E +H +NN D D AL++I + +GIK PVCL V D +SK L V G+G TL + L + VP+I + C + ++ ++ GY+ AG T GDSGGPL+ K NG Y G TS+G +G Q K PGVY +I + WI+ G Sbjct: 16 CGATVIDDFWLVTAAHCALQLQT----RSFVYVREPKNNRERSFSVKEAYIHSGYNNQTADNDIALLRISSDLSKLGIK------PVCL-----VHD-DSKLLKQYKNGVVIGYGLTLGEDSSGEPKLINSQTLQSTSVPIISDDDCVKTWRFLSLLSVKITGYQICAGAYLHGTAPGDSGGPLLIHKSNGEYVQIGITSYGADGLDGVIDQGKFPGVYTRISKYVPWIQGVIG 233
BLAST of Neurotrypsin vs. Ensembl Fly
Match: teq (gene:FBgn0023479 transcript:FBtr0076525) HSP 1 Score: 335.88 bits (860), Expect = 3.066e-93 Identity = 217/624 (34.78%), Postives = 313/624 (50.16%), Query Frame = 1 Query: 2044 FKCTRGMCIELSKKCDHRDNCGDNSDEIDCTTVTFPP--FEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVD-RACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKC--TVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKP------------------TAKVDPAAGL-----KCGHRP-------------IVHKRGRVVGGFEAVYGAFPWQVGVRQK-VDDYDSHWCGASILSEDWIIGAAHC-YARPKSDYRVRTGD-WDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPNSKCLVSGWGDT---LSTYPEKLLAAEVPLIKHERCFE--FYKGRLTERMQCAGYEAGGIDTCQGDSGGPLVCKVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQTGL*LVVRKLNDKLVQF 3768 F C G C++ + CD + NC + DE +C PP +E+RL+G + G++EV+ G+WG+VCDD F +K A+VVC++LGF + + + N+ N L+DE++C G E L +C W HNC DE+AGV CKV C N+ + C K CI + VCD T DC+D SDE C V+ L G ++ GR+E+ G+ G+VCDDD++ K A V C + G A+ I+ FG G I LD + C G E +++ C + WGEH C H ED+ + C PP+ T K GL K H P H+ RVV G A G PWQ +R + SHWCGA ++S+ ++ AAHC Y PK Y VR GD + N ++ F IE LH N+ + + + + + +KF++YVQP+CLP + KC +SGWG +ST + L +AE+P++ C + Y ++E M CAG +D C+GDSGGPLVC + T++G SWG C PGVY ++ +DWI E K+N+ L++F Sbjct: 851 FDCGNGQCLKKEEICDGKKNCPNGKDEANC-----PPSDYEVRLSGGESPNMGRIEVKANGQWGYVCDDKFGLKDADVVCRELGFQMGAQEVRGSSFYAPPNQDFNYLMDEVECHGNETKLGQCAFKGWGVHNCGVDEVAGVTCKVPVMKCPNNYWLCHTSKECIPPAFVCDNTPDCADKSDECAAVCQAPVQYRLEGGRNSNEGRLEVKHHGVWGSVCDDDFNLKSAQVACNSMGFFGPAK-IEKNIFGNSNGPIWLDQVMCFGNETSIDQCNHWNWGEHNCNHTEDVALHCS-----AGPPPRSQRYSQTQIKGGRSLGRETTPKTYSQIGLWERSSKAVHTPRRCGIFKDDLTDEYAHREERVVRGNVAQRGRHPWQATIRTRGRGGISSHWCGAVVISKRHLLTAAHCLYGSPKGAYFVRVGDHYANIAESSEVDSF-IENWYLHENFRKGTHMNNDIALVVLK---TPLKFSDYVQPICLPDKNAELVEDRKCTISGWGSIKSGVSTPAQVLGSAELPILADHVCKQSNVYGSAMSEGMFCAGSMDESVDACEGDSGGPLVCSDDDGETLYGLISWGQHCGFKNRPGVYVRVNHYIDWIYE---------KINESLLRF 1450 HSP 2 Score: 122.479 bits (306), Expect = 3.242e-27 Identity = 94/348 (27.01%), Postives = 148/348 (42.53%), Query Frame = 1 Query: 1561 NEVCDKIPHCLGKEDEDHGFCKKYLCKENEFFCASDMFCILKTHVCDGKRNCADGSDEKNCTVLDESALLKVYDKTDSKILDVSDKLDYIDIPIDKCAEK-----CKILFHQFACKSFN----YLPPHESRTH----SECRLLTKLASEEPYKLIAITYPGAHYSMKSDCTAEQFKC--------TRGMCIELSKKCDHRDNCGDNSDEIDCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSK 2541 N+ D +P+ +E + + +F C + C+ K +CDGK+NC +G DE NC D L + + ++V + + DK K C+ L Q + Y PP++ + EC + +K + G C KC T CI + CD+ +C D SDE C V P + RL G N EG++EV++ G WG VCDD F++K+A+V C +GF G + N FG + P + +D++ C G E S+++C H W HNC E + C + + ++ K SL + Sbjct: 821 NDDWDLLPNSNAEEVTPKLATRSSFNTQCDFDCGNGQ-CLKKEEICDGKKNCPNGKDEANCPPSDYEVRLSGGESPNMGRIEVKANGQWGYVCDDKFGLKDADVVCRELGFQMGAQEVRGSSFYAPPNQDFNYLMDEVECHGNETKLGQCAFKGWGVHNCGVDEVAGVTCKVPVMKCPNNYWLCHTSKECIPPAFVCDNTPDCADKSDE--CAAVCQAPVQYRLEGGRNSNEGRLEVKHHGVWGSVCDDDFNLKSAQVACNSMGFFGPAK---IEKNIFGNSNGP-IWLDQVMCFGNETSIDQCNHWNWGEHNCNHTEDVALHCSAGPPPRSQRYSQTQIKGGRSLGR 1161 HSP 3 Score: 69.707 bits (169), Expect = 3.825e-11 Identity = 50/165 (30.30%), Postives = 73/165 (44.24%), Query Frame = 1 Query: 2434 NCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPE-GKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGA---IVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLP 2916 N +E+ + T +F C + C+ ++CD +C +G DE +V L+ G GR+E+ G G VCDD + KDA V+CR L AQ ++ F ++D ++C G E L C F WG H C E GV C +P Sbjct: 829 NSNAEEVTPKLATRSSFNTQCDFDCGNGQ-CLKKEEICDGKKNCPNGKDEANCPPSDYEVRLSGGESPNMGRIEVKANGQWGYVCDDKFGLKDADVVCRELGFQMGAQEVRGSSFYAPPNQDFNYLMDEVECHGNETKLGQCAFKGWGVHNCGVDEVAGVTCKVP 992 HSP 4 Score: 61.2326 bits (147), Expect = 1.390e-8 Identity = 43/125 (34.40%), Postives = 63/125 (50.40%), Query Frame = 1 Query: 343 PESPQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPHDSTSYCS---GKSAGVSC-VYNLGCPNGW 705 P S +RL G + N GR+EV + WG VCDD + + DA+V CR+LGF+ A+E Y + N Y + +++C GNE L C + + AGV+C V + CPN + Sbjct: 881 PPSDYEVRLSG--GESPNMGRIEVKANGQ--WGYVCDDKFGLKDADVVCRELGFQMGAQEVRGSSFYAPPNQDFN-YLMDEVECHGNETKLGQCAFKGWGVHNCGVDEVAGVTCKVPVMKCPNNY 1000
BLAST of Neurotrypsin vs. Ensembl Fly
Match: teq (gene:FBgn0023479 transcript:FBtr0344980) HSP 1 Score: 337.806 bits (865), Expect = 1.064e-92 Identity = 217/624 (34.78%), Postives = 313/624 (50.16%), Query Frame = 1 Query: 2044 FKCTRGMCIELSKKCDHRDNCGDNSDEIDCTTVTFPP--FEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVD-RACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCT--VKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKP------------------TAKVDPAAGL-----KCGHRP-------------IVHKRGRVVGGFEAVYGAFPWQVGVRQK-VDDYDSHWCGASILSEDWIIGAAHC-YARPKSDYRVRTGD-WDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPNSKCLVSGWGDT---LSTYPEKLLAAEVPLIKHERCFE--FYKGRLTERMQCAGYEAGGIDTCQGDSGGPLVCKVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQTGL*LVVRKLNDKLVQF 3768 F C G C++ + CD + NC + DE +C PP +E+RL+G + G++EV+ G+WG+VCDD F +K A+VVC++LGF + + + N+ N L+DE++C G E L +C W HNC DE+AGV CKV C N+ + C K CI + VCD T DC+D SDE C V+ L G ++ GR+E+ G+ G+VCDDD++ K A V C + G A+ I+ FG G I LD + C G E +++ C + WGEH C H ED+ + C PP+ T K GL K H P H+ RVV G A G PWQ +R + SHWCGA ++S+ ++ AAHC Y PK Y VR GD + N ++ F IE LH N+ + + + + + +KF++YVQP+CLP + KC +SGWG +ST + L +AE+P++ C + Y ++E M CAG +D C+GDSGGPLVC + T++G SWG C PGVY ++ +DWI E K+N+ L++F Sbjct: 1780 FDCGNGQCLKKEEICDGKKNCPNGKDEANC-----PPSDYEVRLSGGESPNMGRIEVKANGQWGYVCDDKFGLKDADVVCRELGFQMGAQEVRGSSFYAPPNQDFNYLMDEVECHGNETKLGQCAFKGWGVHNCGVDEVAGVTCKVPVMKCPNNYWLCHTSKECIPPAFVCDNTPDCADKSDECAAVCQAPVQYRLEGGRNSNEGRLEVKHHGVWGSVCDDDFNLKSAQVACNSMGFFGPAK-IEKNIFGNSNGPIWLDQVMCFGNETSIDQCNHWNWGEHNCNHTEDVALHCS-----AGPPPRSQRYSQTQIKGGRSLGRETTPKTYSQIGLWERSSKAVHTPRRCGIFKDDLTDEYAHREERVVRGNVAQRGRHPWQATIRTRGRGGISSHWCGAVVISKRHLLTAAHCLYGSPKGAYFVRVGDHYANIAESSEVDSF-IENWYLHENFRKGTHMNNDIALVVLKTP---LKFSDYVQPICLPDKNAELVEDRKCTISGWGSIKSGVSTPAQVLGSAELPILADHVCKQSNVYGSAMSEGMFCAGSMDESVDACEGDSGGPLVCSDDDGETLYGLISWGQHCGFKNRPGVYVRVNHYIDWIYE---------KINESLLRF 2379 HSP 2 Score: 122.094 bits (305), Expect = 5.162e-27 Identity = 89/310 (28.71%), Postives = 135/310 (43.55%), Query Frame = 1 Query: 1675 CILKTHVCDGKRNCADGSDEKNCTVLDESALLKVYDKTDSKILDVSDKLDYIDIPIDKCAEK-----CKILFHQFACK----SFNYLPPHESRTH----SECRLLTKLASEEPYKLIAITYPGAHYSMKSDCTAEQFKC--------TRGMCIELSKKCDHRDNCGDNSDEIDCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSK 2541 C+ K +CDGK+NC +G DE NC D L + + ++V + + DK K C+ L Q + S Y PP++ + EC + +K + G C KC T CI + CD+ +C D SDE C V P + RL G N EG++EV++ G WG VCDD F++K+A+V C +GF G + N FG + P + +D++ C G E S+++C H W HNC E + C + + ++ K SL + Sbjct: 1787 CLKKEEICDGKKNCPNGKDEANCPPSDYEVRLSGGESPNMGRIEVKANGQWGYVCDDKFGLKDADVVCRELGFQMGAQEVRGSSFYAPPNQDFNYLMDEVECHGNETKLGQCAFKGWGVHNCGVDEVAGVTCKVPVMKCPNNYWLCHTSKECIPPAFVCDNTPDCADKSDE--CAAVCQAPVQYRLEGGRNSNEGRLEVKHHGVWGSVCDDDFNLKSAQVACNSMGFFGPAK---IEKNIFGNSNGP-IWLDQVMCFGNETSIDQCNHWNWGEHNCNHTEDVALHCSAGPPPRSQRYSQTQIKGGRSLGR 2090 HSP 3 Score: 70.0922 bits (170), Expect = 3.320e-11 Identity = 50/165 (30.30%), Postives = 73/165 (44.24%), Query Frame = 1 Query: 2434 NCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPE-GKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGA---IVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLP 2916 N +E+ + T +F C + C+ ++CD +C +G DE +V L+ G GR+E+ G G VCDD + KDA V+CR L AQ ++ F ++D ++C G E L C F WG H C E GV C +P Sbjct: 1758 NSNAEEVTPKLATRSSFNTQCDFDCGNGQ-CLKKEEICDGKKNCPNGKDEANCPPSDYEVRLSGGESPNMGRIEVKANGQWGYVCDDKFGLKDADVVCRELGFQMGAQEVRGSSFYAPPNQDFNYLMDEVECHGNETKLGQCAFKGWGVHNCGVDEVAGVTCKVP 1921 HSP 4 Score: 62.003 bits (149), Expect = 9.551e-9 Identity = 47/134 (35.07%), Postives = 67/134 (50.00%), Query Frame = 1 Query: 316 PMRKVRDGAPESPQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPHD--STSYCS-GKSAGVSC-VYNLGCPNGW 705 P K P S +RL G + N GR+EV +N + WG VCDD + + DA+V CR+LGF+ A+E Y + N Y + +++C GNE L C C + AGV+C V + CPN + Sbjct: 1801 PNGKDEANCPPSDYEVRLSG--GESPNMGRIEV-KANGQ-WGYVCDDKFGLKDADVVCRELGFQMGAQEVRGSSFYAPPNQDFN-YLMDEVECHGNETKLGQCAFKGWGVHNCGVDEVAGVTCKVPVMKCPNNY 1929
BLAST of Neurotrypsin vs. Ensembl Fly
Match: teq (gene:FBgn0023479 transcript:FBtr0344981) HSP 1 Score: 337.421 bits (864), Expect = 2.125e-92 Identity = 217/624 (34.78%), Postives = 313/624 (50.16%), Query Frame = 1 Query: 2044 FKCTRGMCIELSKKCDHRDNCGDNSDEIDCTTVTFPP--FEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVD-RACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKC--TVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKP------------------TAKVDPAAGL-----KCGHRP-------------IVHKRGRVVGGFEAVYGAFPWQVGVRQK-VDDYDSHWCGASILSEDWIIGAAHC-YARPKSDYRVRTGD-WDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPNSKCLVSGWGDT---LSTYPEKLLAAEVPLIKHERCFE--FYKGRLTERMQCAGYEAGGIDTCQGDSGGPLVCKVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQTGL*LVVRKLNDKLVQF 3768 F C G C++ + CD + NC + DE +C PP +E+RL+G + G++EV+ G+WG+VCDD F +K A+VVC++LGF + + + N+ N L+DE++C G E L +C W HNC DE+AGV CKV C N+ + C K CI + VCD T DC+D SDE C V+ L G ++ GR+E+ G+ G+VCDDD++ K A V C + G A+ I+ FG G I LD + C G E +++ C + WGEH C H ED+ + C PP+ T K GL K H P H+ RVV G A G PWQ +R + SHWCGA ++S+ ++ AAHC Y PK Y VR GD + N ++ F IE LH N+ + + + + + +KF++YVQP+CLP + KC +SGWG +ST + L +AE+P++ C + Y ++E M CAG +D C+GDSGGPLVC + T++G SWG C PGVY ++ +DWI E K+N+ L++F Sbjct: 2193 FDCGNGQCLKKEEICDGKKNCPNGKDEANC-----PPSDYEVRLSGGESPNMGRIEVKANGQWGYVCDDKFGLKDADVVCRELGFQMGAQEVRGSSFYAPPNQDFNYLMDEVECHGNETKLGQCAFKGWGVHNCGVDEVAGVTCKVPVMKCPNNYWLCHTSKECIPPAFVCDNTPDCADKSDECAAVCQAPVQYRLEGGRNSNEGRLEVKHHGVWGSVCDDDFNLKSAQVACNSMGFFGPAK-IEKNIFGNSNGPIWLDQVMCFGNETSIDQCNHWNWGEHNCNHTEDVALHCS-----AGPPPRSQRYSQTQIKGGRSLGRETTPKTYSQIGLWERSSKAVHTPRRCGIFKDDLTDEYAHREERVVRGNVAQRGRHPWQATIRTRGRGGISSHWCGAVVISKRHLLTAAHCLYGSPKGAYFVRVGDHYANIAESSEVDSF-IENWYLHENFRKGTHMNNDIALVVLKTP---LKFSDYVQPICLPDKNAELVEDRKCTISGWGSIKSGVSTPAQVLGSAELPILADHVCKQSNVYGSAMSEGMFCAGSMDESVDACEGDSGGPLVCSDDDGETLYGLISWGQHCGFKNRPGVYVRVNHYIDWIYE---------KINESLLRF 2792 HSP 2 Score: 122.094 bits (305), Expect = 5.912e-27 Identity = 89/310 (28.71%), Postives = 135/310 (43.55%), Query Frame = 1 Query: 1675 CILKTHVCDGKRNCADGSDEKNCTVLDESALLKVYDKTDSKILDVSDKLDYIDIPIDKCAEK-----CKILFHQFACK----SFNYLPPHESRTH----SECRLLTKLASEEPYKLIAITYPGAHYSMKSDCTAEQFKC--------TRGMCIELSKKCDHRDNCGDNSDEIDCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSK 2541 C+ K +CDGK+NC +G DE NC D L + + ++V + + DK K C+ L Q + S Y PP++ + EC + +K + G C KC T CI + CD+ +C D SDE C V P + RL G N EG++EV++ G WG VCDD F++K+A+V C +GF G + N FG + P + +D++ C G E S+++C H W HNC E + C + + ++ K SL + Sbjct: 2200 CLKKEEICDGKKNCPNGKDEANCPPSDYEVRLSGGESPNMGRIEVKANGQWGYVCDDKFGLKDADVVCRELGFQMGAQEVRGSSFYAPPNQDFNYLMDEVECHGNETKLGQCAFKGWGVHNCGVDEVAGVTCKVPVMKCPNNYWLCHTSKECIPPAFVCDNTPDCADKSDE--CAAVCQAPVQYRLEGGRNSNEGRLEVKHHGVWGSVCDDDFNLKSAQVACNSMGFFGPAK---IEKNIFGNSNGP-IWLDQVMCFGNETSIDQCNHWNWGEHNCNHTEDVALHCSAGPPPRSQRYSQTQIKGGRSLGR 2503 HSP 3 Score: 70.0922 bits (170), Expect = 3.143e-11 Identity = 50/165 (30.30%), Postives = 73/165 (44.24%), Query Frame = 1 Query: 2434 NCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPE-GKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGA---IVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLP 2916 N +E+ + T +F C + C+ ++CD +C +G DE +V L+ G GR+E+ G G VCDD + KDA V+CR L AQ ++ F ++D ++C G E L C F WG H C E GV C +P Sbjct: 2171 NSNAEEVTPKLATRSSFNTQCDFDCGNGQ-CLKKEEICDGKKNCPNGKDEANCPPSDYEVRLSGGESPNMGRIEVKANGQWGYVCDDKFGLKDADVVCRELGFQMGAQEVRGSSFYAPPNQDFNYLMDEVECHGNETKLGQCAFKGWGVHNCGVDEVAGVTCKVP 2334 HSP 4 Score: 62.003 bits (149), Expect = 9.320e-9 Identity = 47/134 (35.07%), Postives = 67/134 (50.00%), Query Frame = 1 Query: 316 PMRKVRDGAPESPQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPHD--STSYCS-GKSAGVSC-VYNLGCPNGW 705 P K P S +RL G + N GR+EV +N + WG VCDD + + DA+V CR+LGF+ A+E Y + N Y + +++C GNE L C C + AGV+C V + CPN + Sbjct: 2214 PNGKDEANCPPSDYEVRLSG--GESPNMGRIEV-KANGQ-WGYVCDDKFGLKDADVVCRELGFQMGAQEVRGSSFYAPPNQDFN-YLMDEVECHGNETKLGQCAFKGWGVHNCGVDEVAGVTCKVPVMKCPNNY 2342
BLAST of Neurotrypsin vs. Ensembl Fly
Match: CG31954 (gene:FBgn0051954 transcript:FBtr0077563) HSP 1 Score: 152.91 bits (385), Expect = 1.497e-40 Identity = 99/244 (40.57%), Postives = 136/244 (55.74%), Query Frame = 1 Query: 3010 GRVVGGFEAVYGAFPWQVGVRQKVDDYDSHWCGASILSEDWIIGAAHC-YARPKSDYRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPNSKCLVSGWGDT--LSTYPEKLLAAEVPLIKHERCFEFYK--GRLTERMQCAGYEAGGIDTCQGDSGGPLVCKVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQTGL 3726 GR+VGG P QV ++ SH CG SI+SE+WI+ AAHC Y + +VR G + A Q+ +++++ H +N N DYD++L+++ IKF+ + V LP+ M C VSGWG+T L E L EVPL+ E C E YK G +TERM CAG+ GG D CQGDSGGP+V + + G SWG GCA+P PGVY+++ DWIKE +G+ Sbjct: 49 GRIVGGHRINITDAPHQVSLQT-----SSHICGGSIISEEWILTAAHCTYGKTADRLKVRLGTSEFARSG---QLLRVQKIVQHAQFNYTNVDYDFSLLQLAHP----IKFDETKKAVKLPESQMKYMDGEACFVSGWGNTQNLLESREWLRQVEVPLVNQELCSEKYKQYGGVTERMICAGFLEGGKDACQGDSGGPMVSESG---ELVGVVSWGYGCAKPDYPGVYSRVSFARDWIKEHSGV 277
BLAST of Neurotrypsin vs. Ensembl Fly
Match: CG8172 (gene:FBgn0033362 transcript:FBtr0301191) HSP 1 Score: 149.058 bits (375), Expect = 3.567e-38 Identity = 92/262 (35.11%), Postives = 141/262 (53.82%), Query Frame = 1 Query: 2962 PAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDSHWCGASILSEDWIIGAAHCYAR-PKSDYRVRTGDWDNASDDKY--EQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPNSKCLVSGWGDTL---STYPEKLLAAEVPLIKHERCFEFYK--GR---LTERMQCAGYEAGGIDTCQGDSGGPLVCKVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKE 3714 P CG + + R+VGG +G+ PWQV + + CG +++S W+I AAHC A P S+ ++R G+WD ++ + + IE +HP++N A++ D ALI+++RN + + ++ PVCLP V+GWG T ST P L +V +I ++RC +++ GR + + CAGY+ GG D+CQGDSGGPL ++G T+ G SWG GC + PGVY IQ + WI + Sbjct: 110 PVNNTSCGE--VYTRSNRIVGGHSTGFGSHPWQVALIKSGFLTRKLSCGGALISNRWVITAAHCVASTPNSNMKIRLGEWDVRGQEERLNHEEYGIERKEVHPHYNPADFVNDVALIRLDRN----VVYKQHIIPVCLPP-STTKLTGKMATVAGWGRTRHGQSTVPSVLQEVDVEVISNDRCQRWFRAAGRREAIHDVFLCAGYKDGGRDSCQGDSGGPLTLTMDGRKTLIGLVSWGIGCGREHLPGVYTNIQRFVPWINK 364
BLAST of Neurotrypsin vs. Ensembl Zebrafish
Match: prss12 (serine protease 12 [Source:ZFIN;Acc:ZDB-GENE-090313-45]) HSP 1 Score: 304.679 bits (779), Expect = 3.706e-88 Identity = 206/596 (34.56%), Postives = 315/596 (52.85%), Query Frame = 1 Query: 1984 IAITYPGAHYSMKSD-CTAEQFKCTRG-MCIELSKKCDHRDNCGDNSDEIDCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDSHW-CGASILSEDWIIGAAHCYARPKSD---YRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERN------DGVGIKFNNYVQPVCLP-KLGMVPDPNSKCLVSGWGDTLSTYPEKLLAAEVPLIKHERCFEFYKGRLTERMQCAG--YEAGGIDTCQGDSGGPLVC-KVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQTG 3723 IA + GA++ S ++ CT + IE K ++ D++++ + V +RL G V YEG++EV Y+G+WG VCDDG+ +VVC+QLGF ES+ + RFG P +L+D+++CTG E ++ C W H+C + +VC +CS+ + SL V L G + + GRVE+ GG GTVCDD + D+DA V+CR L G A+A FGEG G I +DN+KCTG E +L +C +G H C H ED GVIC Q P K A G CG R ++ R++GG ++ G +PWQ VR + D CGA+++S WI+ +AHC+ R + Y+VR GD+ + ++YE+ + +E+++LHP ++ + DYD AL+++ + G + + V P CLP + VP + C ++GWGDT Y + L A + ++ +C + Y + T RM CAG ++A +D+C+GDSGGPLVC + +G + ++G TSWG+ C + PGVY K+ + WIK+ G Sbjct: 113 IAKAWVGAYFGAGSGRVFLDEVSCTGNELSIEQCPKTAWGEHNCDHTEDAGVSCVPLTDGAVRLVGGVKGYEGRLEVHYRGQWGTVCDDGWTQTNTQVVCRQLGFRSG-ESV--SAGRFGIAAGP-VLLDDVRCTGKEPTVTHCSRRGWFKHDCTHRQDVAIVCSP---------QCSRHGVPNSL-----------------------PVRLVGGENEREGRVEILVGGQWGTVCDDGWTDRDAEVVCRQLGYSGLAKARVMAYFGEGEGPIHIDNVKCTGGEHSLTDCIKQPFGTHNCRHSEDAGVICNYG----LQQDSPGVK--EAVGSMCGLRLSHTRQKRIIGGENSLRGGWPWQAAVRLRGSQADGRLVCGATLISSCWILTSAHCFKRYGNSTGLYKVRVGDYHSLVPEEYEEEYAVEKIVLHPRYHADSSDYDLALLRVSGHRAHRGVTGQCVTLSRSVLPACLPVRREKVPKGIANCYITGWGDTGRAYSKTLQQASISVLSKRQCEQRYSEQFTNRMLCAGSSHDAQRVDSCRGDSGGPLVCERPSGSWVVYGVTSWGHACRLQEAPGVYTKVSAFVPWIKKVIG 666 HSP 2 Score: 139.428 bits (350), Expect = 5.343e-33 Identity = 89/257 (34.63%), Postives = 130/257 (50.58%), Query Frame = 1 Query: 2137 TVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVIC 2907 T F P +RL+G + YEG+VEV + G+WG VCDD +D AEVVC+QLG G ++ A G R + +DE+ CTG E S+E+C + W HNC E AGV C+ L +DG+ V L G GR+E+ G GTVCDD + + V+CR L +++ RFG AG ++LD+++CTG+E + +C W +H CTH++D+ ++C Sbjct: 61 TSVFVP--VRLSGGPSAYEGRVEVYHAGQWGTVCDDQWDDNDAEVVCRQLGLGGIAKAWVGAYFGAGSGR---VFLDEVSCTGNELSIEQCPKTAWGEHNCDHTEDAGV-------------------SCVPL----------TDGA----------VRLVGGVKGYEGRLEVHYRGQWGTVCDDGWTQTNTQVVCRQLGFR-SGESVSAGRFGIAAGPVLLDDVRCTGKEPTVTHCSRRGWFKHDCTHRQDVAIVC 272 HSP 3 Score: 95.1301 bits (235), Expect = 4.720e-19 Identity = 64/179 (35.75%), Postives = 80/179 (44.69%), Query Frame = 1 Query: 2371 IKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVIC 2907 + C G E+ L +C + W C + A V C E V V L+ GP A GRVE+ G GTVCDD +DD DA V+CR L + G A+A FG G+G + LD + CTG EL++E CP WGEH C H ED GV C Sbjct: 24 VGCEGQEDDLLQCNRTVWNGGECENRQAAAVSCM------------------------------------PVETSVFVPVRLSGGPSAYEGRVEVYHAGQWGTVCDDQWDDNDAEVVCRQLGLGGIAKAWVGAYFGAGSGRVFLDEVSCTGNELSIEQCPKTAWGEHNCDHTEDAGVSC 166 HSP 4 Score: 67.3958 bits (163), Expect = 1.763e-10 Identity = 46/122 (37.70%), Postives = 61/122 (50.00%), Query Frame = 1 Query: 331 RDGAPESPQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDC---PHDSTSYCSGKSAGVSCVYNL 687 R G P S + + GEN EGRVE+ WG VCDD W DA V CRQLG+ A+ A +G G+ ++ + ++CTG E SL DC P + + + AGV C Y L Sbjct: 278 RHGVPNSLPVRLVGGENE---REGRVEILVGGQ--WGTVCDDGWTDRDAEVVCRQLGYSGLAK-ARVMAYFGEGEGPIH---IDNVKCTGGEHSLTDCIKQPFGTHNCRHSEDAGVICNYGL 390 HSP 5 Score: 61.2326 bits (147), Expect = 1.302e-8 Identity = 45/114 (39.47%), Postives = 59/114 (51.75%), Query Frame = 1 Query: 346 ESPQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPHDS--TSYC-SGKSAGVSCV 678 E+ + +R +A EGRVEVY + WG VCDD W+ DA V CRQLG A+ A +G G V + ++ CTGNE S+ CP + C + AGVSCV Sbjct: 60 ETSVFVPVRLSGGPSAYEGRVEVYHAGQ--WGTVCDDQWDDNDAEVVCRQLGLGGIAK-AWVGAYFGAGSGRV---FLDEVSCTGNELSIEQCPKTAWGEHNCDHTEDAGVSCV 167 HSP 6 Score: 53.1434 bits (126), Expect = 4.975e-6 Identity = 32/95 (33.68%), Postives = 47/95 (49.47%), Query Frame = 1 Query: 340 APESPQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDC 624 P + +RL G + EGR+EV+ WG VCDD W + V CRQLGFR + E+ R+G + + ++CTG E ++ C Sbjct: 167 VPLTDGAVRLVG--GVKGYEGRLEVHYRGQ--WGTVCDDGWTQTNTQVVCRQLGFR--SGESVSAGRFG---IAAGPVLLDDVRCTGKEPTVTHC 252
BLAST of Neurotrypsin vs. Ensembl Zebrafish
Match: prss12 (serine protease 12 [Source:ZFIN;Acc:ZDB-GENE-090313-45]) HSP 1 Score: 306.605 bits (784), Expect = 2.440e-87 Identity = 205/596 (34.40%), Postives = 315/596 (52.85%), Query Frame = 1 Query: 1984 IAITYPGAHYSMKSD-CTAEQFKCTRG-MCIELSKKCDHRDNCGDNSDEIDCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDSHW-CGASILSEDWIIGAAHCYARPKSD---YRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERN------DGVGIKFNNYVQPVCLP-KLGMVPDPNSKCLVSGWGDTLSTYPEKLLAAEVPLIKHERCFEFYKGRLTERMQCAG--YEAGGIDTCQGDSGGPLVC-KVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQTG 3723 IA + GA++ S ++ CT + IE K ++ D++++ + V +RL G V YEG++EV Y+G+WG VCDDG+ +VVC+QLGF ES+ + RFG P +L+D+++CTG E ++ C W H+C + +VC +CS+ + SL V L G + + GRVE+ GG GTVCDD + D+DA V+CR L G A+A FGEG G I +DN+KCTG E +L +C +G H C H ED GVIC Q P KV GL+ H ++ R++GG ++ G +PWQ VR + D CGA+++S WI+ +AHC+ R + Y+VR GD+ + ++YE+ + +E+++LHP ++ + DYD AL+++ + G + + V P CLP + VP + C ++GWGDT Y + L A + ++ +C + Y + T RM CAG ++A +D+C+GDSGGPLVC + +G + ++G TSWG+ C + PGVY K+ + WIK+ G Sbjct: 264 IAKAWVGAYFGAGSGRVFLDEVSCTGNELSIEQCPKTAWGEHNCDHTEDAGVSCVPLTDGAVRLVGGVKGYEGRLEVHYRGQWGTVCDDGWTQTNTQVVCRQLGFRSG-ESV--SAGRFGIAAGP-VLLDDVRCTGKEPTVTHCSRRGWFKHDCTHRQDVAIVCSP---------QCSRHGVPNSL-----------------------PVRLVGGENEREGRVEILVGGQWGTVCDDGWTDRDAEVVCRQLGYSGLAKARVMAYFGEGEGPIHIDNVKCTGGEHSLTDCIKQPFGTHNCRHSEDAGVICNYG----LQQDSPGVKVGSMCGLRLSHT----RQKRIIGGENSLRGGWPWQAAVRLRGSQADGRLVCGATLISSCWILTSAHCFKRYGNSTGLYKVRVGDYHSLVPEEYEEEYAVEKIVLHPRYHADSSDYDLALLRVSGHRAHRGVTGQCVTLSRSVLPACLPVRREKVPKGIANCYITGWGDTGRAYSKTLQQASISVLSKRQCEQRYSEQFTNRMLCAGSSHDAQRVDSCRGDSGGPLVCERPSGSWVVYGVTSWGHACRLQEAPGVYTKVSAFVPWIKKVIG 815 HSP 2 Score: 139.813 bits (351), Expect = 1.059e-32 Identity = 89/257 (34.63%), Postives = 130/257 (50.58%), Query Frame = 1 Query: 2137 TVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVIC 2907 T F P +RL+G + YEG+VEV + G+WG VCDD +D AEVVC+QLG G ++ A G R + +DE+ CTG E S+E+C + W HNC E AGV C+ L +DG+ V L G GR+E+ G GTVCDD + + V+CR L +++ RFG AG ++LD+++CTG+E + +C W +H CTH++D+ ++C Sbjct: 212 TSVFVP--VRLSGGPSAYEGRVEVYHAGQWGTVCDDQWDDNDAEVVCRQLGLGGIAKAWVGAYFGAGSGR---VFLDEVSCTGNELSIEQCPKTAWGEHNCDHTEDAGV-------------------SCVPL----------TDGA----------VRLVGGVKGYEGRLEVHYRGQWGTVCDDGWTQTNTQVVCRQLGFR-SGESVSAGRFGIAAGPVLLDDVRCTGKEPTVTHCSRRGWFKHDCTHRQDVAIVC 423 HSP 3 Score: 129.028 bits (323), Expect = 2.504e-29 Identity = 89/266 (33.46%), Postives = 119/266 (44.74%), Query Frame = 1 Query: 2110 DNSDEIDCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVIC 2907 +N ID +RL G +K +G VEV G WG +C +G+D + A VVC+QLG H+ ++ + + + C G E+ L +C + W C + A V C E V V L+ GP A GRVE+ G GTVCDD +DD DA V+CR L + G A+A FG G+G + LD + CTG EL++E CP WGEH C H ED GV C Sbjct: 91 NNRGRIDWGYCDCKQGSLRLQGGRSKLDGTVEVYLNGVWGTICSNGWDDQDAAVVCRQLG---QGYRAHARMSPLSRLVVSVVHWQTVGCEGQEDDLLQCNRTVWNGGECENRQAAAVSCM------------------------------------PVETSVFVPVRLSGGPSAYEGRVEVYHAGQWGTVCDDQWDDNDAEVVCRQLGLGGIAKAWVGAYFGAGSGRVFLDEVSCTGNELSIEQCPKTAWGEHNCDHTEDAGVSC 317 HSP 4 Score: 65.4698 bits (158), Expect = 8.514e-10 Identity = 46/122 (37.70%), Postives = 61/122 (50.00%), Query Frame = 1 Query: 331 RDGAPESPQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDC---PHDSTSYCSGKSAGVSCVYNL 687 R G P S + + GEN EGRVE+ WG VCDD W DA V CRQLG+ A+ A +G G+ ++ + ++CTG E SL DC P + + + AGV C Y L Sbjct: 429 RHGVPNSLPVRLVGGENE---REGRVEILVGGQ--WGTVCDDGWTDRDAEVVCRQLGYSGLAK-ARVMAYFGEGEGPIH---IDNVKCTGGEHSLTDCIKQPFGTHNCRHSEDAGVICNYGL 541 HSP 5 Score: 60.4622 bits (145), Expect = 2.423e-8 Identity = 44/114 (38.60%), Postives = 59/114 (51.75%), Query Frame = 1 Query: 346 ESPQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPHDSTSYCS---GKSAGVSCV 678 E+ + +R +A EGRVEVY + WG VCDD W+ DA V CRQLG A+ A +G G V + ++ CTGNE S+ CP + + + AGVSCV Sbjct: 211 ETSVFVPVRLSGGPSAYEGRVEVYHAGQ--WGTVCDDQWDDNDAEVVCRQLGLGGIAK-AWVGAYFGAGSGRV---FLDEVSCTGNELSIEQCPKTAWGEHNCDHTEDAGVSCV 318 HSP 6 Score: 53.5286 bits (127), Expect = 3.591e-6 Identity = 31/78 (39.74%), Postives = 38/78 (48.72%), Query Frame = 1 Query: 1192 SDCYEDNGLD--YRGRISRTVQGSSCAKWTD-PAATVNPQTNPEAGLGDHNFCRNPDNDLQPWCWTNPTNGV--YGYC 1410 +DC + G Y G I T G C W+D P Q GLGDH FCRNPD ++PWC+ G +GYC Sbjct: 27 TDCVQSKGKAGFYEGSIDSTESGVKCMNWSDVPGVRERYQGK---GLGDHTFCRNPDGRIRPWCFFTNNRGRIDWGYC 101
BLAST of Neurotrypsin vs. Ensembl Zebrafish
Match: BX511095.2 (serine protease 12 [Source:NCBI gene;Acc:566809]) HSP 1 Score: 306.605 bits (784), Expect = 2.533e-87 Identity = 205/596 (34.40%), Postives = 315/596 (52.85%), Query Frame = 1 Query: 1984 IAITYPGAHYSMKSD-CTAEQFKCTRG-MCIELSKKCDHRDNCGDNSDEIDCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDSHW-CGASILSEDWIIGAAHCYARPKSD---YRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERN------DGVGIKFNNYVQPVCLP-KLGMVPDPNSKCLVSGWGDTLSTYPEKLLAAEVPLIKHERCFEFYKGRLTERMQCAG--YEAGGIDTCQGDSGGPLVC-KVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQTG 3723 IA + GA++ S ++ CT + IE K ++ D++++ + V +RL G V YEG++EV Y+G+WG VCDDG+ +VVC+QLGF ES+ + RFG P +L+D+++CTG E ++ C W H+C + +VC +CS+ + SL V L G + + GRVE+ GG GTVCDD + D+DA V+CR L G A+A FGEG G I +DN+KCTG E +L +C +G H C H ED GVIC Q P KV GL+ H ++ R++GG ++ G +PWQ VR + D CGA+++S WI+ +AHC+ R + Y+VR GD+ + ++YE+ + +E+++LHP ++ + DYD AL+++ + G + + V P CLP + VP + C ++GWGDT Y + L A + ++ +C + Y + T RM CAG ++A +D+C+GDSGGPLVC + +G + ++G TSWG+ C + PGVY K+ + WIK+ G Sbjct: 264 IAKAWVGAYFGAGSGRVFLDEVSCTGNELSIEQCPKTAWGEHNCDHTEDAGVSCVPLTDGAVRLVGGVKGYEGRLEVHYRGQWGTVCDDGWTQTNTQVVCRQLGFRSG-ESV--SAGRFGIAAGP-VLLDDVRCTGKEPTVTHCSRRGWFKHDCTHRQDVAIVCSP---------QCSRHGVPNSL-----------------------PVRLVGGENEREGRVEILVGGQWGTVCDDGWTDRDAEVVCRQLGYSGLAKARVMAYFGEGEGPIHIDNVKCTGGEHSLTDCIKQPFGTHNCRHSEDAGVICNYG----LQQDSPGVKVGSMCGLRLSHT----RQKRIIGGENSLRGGWPWQAAVRLRGSQADGRLVCGATLISSCWILTSAHCFKRYGNSTGLYKVRVGDYHSLVPEEYEEEYAVEKIVLHPRYHADSSDYDLALLRVSGHRAHRGVTGQCVTLSRSVLPACLPVRREKVPKGIANCYITGWGDTGRAYSKTLQQASISVLSKRQCEQRYSEQFTNRMLCAGSSHDAQRVDSCRGDSGGPLVCERPSGSWVVYGVTSWGHACRLQEAPGVYTKVSAFVPWIKKVIG 815 HSP 2 Score: 139.813 bits (351), Expect = 1.014e-32 Identity = 89/257 (34.63%), Postives = 130/257 (50.58%), Query Frame = 1 Query: 2137 TVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVIC 2907 T F P +RL+G + YEG+VEV + G+WG VCDD +D AEVVC+QLG G ++ A G R + +DE+ CTG E S+E+C + W HNC E AGV C+ L +DG+ V L G GR+E+ G GTVCDD + + V+CR L +++ RFG AG ++LD+++CTG+E + +C W +H CTH++D+ ++C Sbjct: 212 TSVFVP--VRLSGGPSAYEGRVEVYHAGQWGTVCDDQWDDNDAEVVCRQLGLGGIAKAWVGAYFGAGSGR---VFLDEVSCTGNELSIEQCPKTAWGEHNCDHTEDAGV-------------------SCVPL----------TDGA----------VRLVGGVKGYEGRLEVHYRGQWGTVCDDGWTQTNTQVVCRQLGFR-SGESVSAGRFGIAAGPVLLDDVRCTGKEPTVTHCSRRGWFKHDCTHRQDVAIVC 423 HSP 3 Score: 129.028 bits (323), Expect = 2.504e-29 Identity = 89/266 (33.46%), Postives = 119/266 (44.74%), Query Frame = 1 Query: 2110 DNSDEIDCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVIC 2907 +N ID +RL G +K +G VEV G WG +C +G+D + A VVC+QLG H+ ++ + + + C G E+ L +C + W C + A V C E V V L+ GP A GRVE+ G GTVCDD +DD DA V+CR L + G A+A FG G+G + LD + CTG EL++E CP WGEH C H ED GV C Sbjct: 91 NNRGRIDWGYCDCKQGSLRLQGGRSKLDGTVEVYLNGVWGTICSNGWDDQDAAVVCRQLG---QGYRAHARMSPLSRLVVSVVHWQTVGCEGQEDDLLQCNRTVWNGGECENRQAAAVSCM------------------------------------PVETSVFVPVRLSGGPSAYEGRVEVYHAGQWGTVCDDQWDDNDAEVVCRQLGLGGIAKAWVGAYFGAGSGRVFLDEVSCTGNELSIEQCPKTAWGEHNCDHTEDAGVSC 317 HSP 4 Score: 65.4698 bits (158), Expect = 8.587e-10 Identity = 46/122 (37.70%), Postives = 61/122 (50.00%), Query Frame = 1 Query: 331 RDGAPESPQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDC---PHDSTSYCSGKSAGVSCVYNL 687 R G P S + + GEN EGRVE+ WG VCDD W DA V CRQLG+ A+ A +G G+ ++ + ++CTG E SL DC P + + + AGV C Y L Sbjct: 429 RHGVPNSLPVRLVGGENE---REGRVEILVGGQ--WGTVCDDGWTDRDAEVVCRQLGYSGLAK-ARVMAYFGEGEGPIH---IDNVKCTGGEHSLTDCIKQPFGTHNCRHSEDAGVICNYGL 541 HSP 5 Score: 60.4622 bits (145), Expect = 2.444e-8 Identity = 44/114 (38.60%), Postives = 59/114 (51.75%), Query Frame = 1 Query: 346 ESPQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPHDSTSYCS---GKSAGVSCV 678 E+ + +R +A EGRVEVY + WG VCDD W+ DA V CRQLG A+ A +G G V + ++ CTGNE S+ CP + + + AGVSCV Sbjct: 211 ETSVFVPVRLSGGPSAYEGRVEVYHAGQ--WGTVCDDQWDDNDAEVVCRQLGLGGIAK-AWVGAYFGAGSGRV---FLDEVSCTGNELSIEQCPKTAWGEHNCDHTEDAGVSCV 318 HSP 6 Score: 53.5286 bits (127), Expect = 3.975e-6 Identity = 31/78 (39.74%), Postives = 38/78 (48.72%), Query Frame = 1 Query: 1192 SDCYEDNGLD--YRGRISRTVQGSSCAKWTD-PAATVNPQTNPEAGLGDHNFCRNPDNDLQPWCWTNPTNGV--YGYC 1410 +DC + G Y G I T G C W+D P Q GLGDH FCRNPD ++PWC+ G +GYC Sbjct: 27 TDCVQSKGKAGFYEGSIDATESGVKCMNWSDVPGVRERYQGK---GLGDHTFCRNPDGRIRPWCFFTNNRGRIDWGYC 101
BLAST of Neurotrypsin vs. Ensembl Zebrafish
Match: si:ch211-51a6.2 (si:ch211-51a6.2 [Source:ZFIN;Acc:ZDB-GENE-090313-118]) HSP 1 Score: 296.59 bits (758), Expect = 1.108e-86 Identity = 206/566 (36.40%), Postives = 303/566 (53.53%), Query Frame = 1 Query: 2071 ELS-KKCDHRDNCGDNSDEIDCTTVTFPPFE---IRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFE-AVYGAFPWQVGVRQKVDDYDSH-WCGASILSEDWIIGAAHCYARPKSD---YRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLP----KLGMVPDPNSKCLVSGWGDTLSTYPEKLLAAEVPLIKHERCFEFYKGRLTERMQCAGYEAGG--IDTCQGDSGGPLVCKVNGV-YTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQT 3720 ELS ++C H N D ++ V+ PF +RL G+ + +EG++EV + GEWG VCDD + + A+VVC+QLG+ G E S V +G+ + +L+DE+ C G E+SL +C HS W H+C E G+ RC ++ + +V T V L DG K GRVE+ G+VCDD ++D +A V+CR L G ++A FGEG G+I LDN+KC G E++L C H C H ED GVIC + VT+P K++ +CG RP +R R + G + ++ G +PWQV + + SH CGA++++ W+I AAHC+ R SD Y +R GD+ D +E+ E +++H +++ ++YD AL+K++ D + FN + VCLP K G P C+++GWG T S Y LL A VPL+ +C + Y R T RM CAG + +D+CQGDSGGPLVC+ +G + + G SWG+GC P PGVY ++ L WI++ T Sbjct: 30 ELSLEECPHAPWGRHNCDHMEDAGVSCNPFTDGVLRLVGADSPWEGRLEVYHAGEWGTVCDDNWTGRHAQVVCRQLGYRGRAEV--SPVGMYGEG-TGMILLDEVTCEGGESSLLDCDHSQWGQHDCSHSEDVGI-------------RCEREGQNNEIPEVAPVTGPL--------------VRLVDGESRKEGRVEVFINAQWGSVCDDGWNDINAQVVCRQLGFVGVSKARSMAYFGEGQGSIHLDNVKCVGTEVSLGECSAVGSDAHDCRHSEDAGVIC----DYVTEP----VKMNSFGKHECGLRPNTQRRRRRIIGGDKSLRGDWPWQVSLWLRSQSKGSHPLCGATLINSCWVITAAHCFKRFGSDASRYVLRLGDYHTEERDDFERSLSPERIVIHKKYHSQGWEYDIALLKLKGTDENCVAFNPHTNAVCLPPQSSKKGKRP---IACVITGWGITDSEYSRTLLQAWVPLLPSWKCKKRYGSRFTSRMLCAGSLSNHRRVDSCQGDSGGPLVCQGDGGHWMLTGVISWGHGCGDPSYPGVYTRVGRFLKWIEKVT 554 HSP 2 Score: 107.071 bits (266), Expect = 5.270e-23 Identity = 69/192 (35.94%), Postives = 95/192 (49.48%), Query Frame = 1 Query: 2332 FGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVIC 2907 FG+ P + +D + CTG E SLEEC H+PW HNC E AGV C N +DG +++ AD P GR+E+ G GTVCDD++ + A V+CR L GRA+ +GEG G I+LD + C G E +L +C +WG+H C+H ED+G+ C Sbjct: 12 FGQGTGP-IALDGVHCTGNELSLEECPHAPWGRHNCDHMEDAGVSC-----------------------------NPFTDG--------VLRLVGADSP--WEGRLEVYHAGEWGTVCDDNWTGRHAQVVCRQLGYRGRAEVSPVGMYGEGTGMILLDEVTCEGGESSLLDCDHSQWGQHDCSHSEDVGIRC 163 HSP 3 Score: 64.3142 bits (155), Expect = 1.351e-9 Identity = 39/96 (40.62%), Postives = 53/96 (55.21%), Query Frame = 1 Query: 343 PESPQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPH 630 P + ++RL G A + EGR+EVY + WG VCDD W A V CRQLG+R +A E + YG G + + ++ C G E SL+DC H Sbjct: 58 PFTDGVLRLVG--ADSPWEGRLEVYHAGE--WGTVCDDNWTGRHAQVVCRQLGYRGRA-EVSPVGMYGEGTGMI---LLDEVTCEGGESSLLDCDH 145 HSP 4 Score: 61.6178 bits (148), Expect = 9.297e-9 Identity = 28/55 (50.91%), Postives = 32/55 (58.18%), Query Frame = 1 Query: 2743 GRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVIC 2907 G +A FG+G G I LD + CTG EL+LE CP WG H C H ED GV C Sbjct: 2 GVPKAWTWAHFGQGTGPIALDGVHCTGNELSLEECPHAPWGRHNCDHMEDAGVSC 56 HSP 5 Score: 59.6918 bits (143), Expect = 3.476e-8 Identity = 42/122 (34.43%), Postives = 65/122 (53.28%), Query Frame = 1 Query: 325 KVRDGAPESPQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCP---HDSTSYCSGKSAGVSCVY 681 ++ + AP + ++RL + + EGRVEV+ + WG VCDD WN ++A V CRQLGF ++ A +G G S++ + ++C G E SL +C D+ + AGV C Y Sbjct: 171 EIPEVAPVTGPLVRLV--DGESRKEGRVEVFINAQ--WGSVCDDGWNDINAQVVCRQLGFVGVSK-ARSMAYFGEGQGSIH---LDNVKCVGTEVSLGECSAVGSDAHDCRHSEDAGVICDY 284
BLAST of Neurotrypsin vs. Ensembl Zebrafish
Match: si:ch211-51a6.2 (si:ch211-51a6.2 [Source:ZFIN;Acc:ZDB-GENE-090313-118]) HSP 1 Score: 296.975 bits (759), Expect = 6.006e-84 Identity = 206/566 (36.40%), Postives = 303/566 (53.53%), Query Frame = 1 Query: 2071 ELS-KKCDHRDNCGDNSDEIDCTTVTFPPFE---IRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFE-AVYGAFPWQVGVRQKVDDYDSH-WCGASILSEDWIIGAAHCYARPKSD---YRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLP----KLGMVPDPNSKCLVSGWGDTLSTYPEKLLAAEVPLIKHERCFEFYKGRLTERMQCAGYEAGG--IDTCQGDSGGPLVCKVNGVYTIF-GATSWGNGCAQPKNPGVYAKIQMQLDWIKEQT 3720 ELS ++C H N D ++ V+ PF +RL G+ + +EG++EV + GEWG VCDD + + A+VVC+QLG+ G E S V +G+ + +L+DE+ C G E+SL +C HS W H+C E G+ RC ++ + +V T V L DG K GRVE+ G+VCDD ++D +A V+CR L G ++A FGEG G+I LDN+KC G E++L C H C H ED GVIC + VT+P K++ +CG RP +R R + G + ++ G +PWQV + + SH CGA++++ W+I AAHC+ R SD Y +R GD+ D +E+ E +++H +++ ++YD AL+K++ D + FN + VCLP K G P C+++GWG T S Y LL A VPL+ +C + Y R T RM CAG + +D+CQGDSGGPLVC+ +G + + G SWG+GC P PGVY ++ L WI++ T Sbjct: 302 ELSLEECPHAPWGRHNCDHMEDAGVSCNPFTDGVLRLVGADSPWEGRLEVYHAGEWGTVCDDNWTGRHAQVVCRQLGYRGRAEV--SPVGMYGEG-TGMILLDEVTCEGGESSLLDCDHSQWGQHDCSHSEDVGI-------------RCEREGQNNEIPEVAPVTGPL--------------VRLVDGESRKEGRVEVFINAQWGSVCDDGWNDINAQVVCRQLGFVGVSKARSMAYFGEGQGSIHLDNVKCVGTEVSLGECSAVGSDAHDCRHSEDAGVIC----DYVTEP----VKMNSFGKHECGLRPNTQRRRRRIIGGDKSLRGDWPWQVSLWLRSQSKGSHPLCGATLINSCWVITAAHCFKRFGSDASRYVLRLGDYHTEERDDFERSLSPERIVIHKKYHSQGWEYDIALLKLKGTDENCVAFNPHTNAVCLPPQSSKKGKRP---IACVITGWGITDSEYSRTLLQAWVPLLPSWKCKKRYGSRFTSRMLCAGSLSNHRRVDSCQGDSGGPLVCQGDGGHWMLTGVISWGHGCGDPSYPGVYTRVGRFLKWIEKVT 826 HSP 2 Score: 155.221 bits (391), Expect = 1.574e-37 Identity = 100/278 (35.97%), Postives = 139/278 (50.00%), Query Frame = 1 Query: 2074 LSKKCDHRDNCGDNSDEIDCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVIC 2907 +S C+H + G + C +RL G + +EG+VEV Y G WG +CDD +D AEVVC+QLG G ++ A FG+ P + +D + CTG E SLEEC H+PW HNC E AGV C N +DG +++ AD P GR+E+ G GTVCDD++ + A V+CR L GRA+ +GEG G I+LD + C G E +L +C +WG+H C+H ED+G+ C Sbjct: 205 VSGDCNHGNEAG-----VICAVPEGNGAPLRLVGGLEDFEGRVEVYYNGRWGTICDDEWDDIDAEVVCRQLGLGGVPKAWTWA--HFGQGTGP-IALDGVHCTGNELSLEECPHAPWGRHNCDHMEDAGVSC-----------------------------NPFTDG--------VLRLVGADSP--WEGRLEVYHAGEWGTVCDDNWTGRHAQVVCRQLGYRGRAEVSPVGMYGEGTGMILLDEVTCEGGESSLLDCDHSQWGQHDCSHSEDVGIRC 435 HSP 3 Score: 119.013 bits (297), Expect = 2.865e-26 Identity = 86/252 (34.13%), Postives = 116/252 (46.03%), Query Frame = 1 Query: 2158 EIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNR--FGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVIC 2907 ++RL G + G++EV G WG VCD + A V+C+QL + I +A+ FG S + + C G E SL +C+ + S +C AGV+C V PEG + L G + GRVE+ G GT+CDD++DD DA V+CR L + G +A FG+G G I LD + CTG EL+LE CP WG H C H ED GV C Sbjct: 119 DVRLVGGSSNKSGRLEVYLNGRWGSVCDSHLTDRDASVICRQL----RLGEIGTALRHSYFGPG-SGLFHFERLGCHGNEESLLKCRTRKYVSGDCNHGNEAGVICAV------------------------------------PEGN-GAPLRLVGGLEDFEGRVEVYYNGRWGTICDDEWDDIDAEVVCRQLGLGGVPKAWTWAHFGQGTGPIALDGVHCTGNELSLEECPHAPWGRHNCDHMEDAGVSC 328 HSP 4 Score: 68.1662 bits (165), Expect = 1.213e-10 Identity = 40/104 (38.46%), Postives = 56/104 (53.85%), Query Frame = 1 Query: 2608 VTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPD 2919 V L G KSGR+E+ G G+VCD D+DA+VICR L++ A++ FG G+G + L C G E +L C K+ C H + GVIC +P+ Sbjct: 120 VRLVGGSSNKSGRLEVYLNGRWGSVCDSHLTDRDASVICRQLRLGEIGTALRHSYFGPGSGLFHFERLGCHGNEESLLKCRTRKYVSGDCNHGNEAGVICAVPE 223 HSP 5 Score: 63.1586 bits (152), Expect = 3.853e-9 Identity = 39/96 (40.62%), Postives = 53/96 (55.21%), Query Frame = 1 Query: 343 PESPQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPH 630 P + ++RL G A + EGR+EVY + WG VCDD W A V CRQLG+R +A E + YG G + + ++ C G E SL+DC H Sbjct: 330 PFTDGVLRLVG--ADSPWEGRLEVYHAGE--WGTVCDDNWTGRHAQVVCRQLGYRGRA-EVSPVGMYGEGTGMI---LLDEVTCEGGESSLLDCDH 417 HSP 6 Score: 62.003 bits (149), Expect = 9.068e-9 Identity = 41/99 (41.41%), Postives = 53/99 (53.54%), Query Frame = 1 Query: 334 DGAPESPQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPH 630 +GAP +RL G L EGRVEVY + WG +CDD W+ +DA V CRQLG + T +G+G + + CTGNE SL +CPH Sbjct: 225 NGAP-----LRLVG--GLEDFEGRVEVYYNGR--WGTICDDEWDDIDAEVVCRQLGLGGVPKAWTWA-HFGQG---TGPIALDGVHCTGNELSLEECPH 310 HSP 7 Score: 58.9214 bits (141), Expect = 9.318e-8 Identity = 42/117 (35.90%), Postives = 62/117 (52.99%), Query Frame = 1 Query: 340 APESPQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCP---HDSTSYCSGKSAGVSCVY 681 AP + ++RL + + EGRVEV+ + WG VCDD WN ++A V CRQLGF ++ A +G G S++ + ++C G E SL +C D+ + AGV C Y Sbjct: 448 APVTGPLVRL--VDGESRKEGRVEVFINAQ--WGSVCDDGWNDINAQVVCRQLGFVGVSK-ARSMAYFGEGQGSIH---LDNVKCVGTEVSLGECSAVGSDAHDCRHSEDAGVICDY 556 HSP 8 Score: 56.9954 bits (136), Expect = 2.924e-7 Identity = 33/81 (40.74%), Postives = 46/81 (56.79%), Query Frame = 1 Query: 1168 QMNIPQSRSDCYEDNGLDYRGRISRTVQGSSCAKWTD-PAATVNPQTNPEAGLGDHNFCRNPDNDLQPWCWTNPTNGVYGY 1407 Q + P S S+ + + G Y G +S+T G SC KWT+ P + P+ GLGDHN CRNPD + PWC+ +G G+ Sbjct: 34 QSSGPLSCSEGFTELGY-YNGSVSQTDTGFSCLKWTEFPDYMLQ---YPKRGLGDHNHCRNPDRESNPWCFFRQKSGAVGW 110
BLAST of Neurotrypsin vs. Ensembl Xenopus
Match: ENSXETT00000001560.1 (neurotrypsin-like [Source:NCBI gene;Acc:100497588]) HSP 1 Score: 316.62 bits (810), Expect = 1.112e-90 Identity = 203/548 (37.04%), Postives = 288/548 (52.55%), Query Frame = 1 Query: 2113 NSDEIDCTTVTFPPF---EIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDSHW-CGASILSEDWIIGAAHCYARPKSD---YRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPNSKCLVSGWGDTLSTYPEKLLAAEVPLIKHERCFEFYKGRLTERMQCAG--YEAGGIDTCQGDSGGPLVC-KVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQTGL 3726 N D I+ V+ PF +RL+G EG VEV Y G+WG VCDDG+ A+VVC+QLGF G S S+ FG + +D++ CTG E SL EC HS W H+C E GV C +N+ +D P G V L DG K GRVE+ G G+VCDD + D DAAV+CR L G A+A FGEG G I +DN++C+G E L C G H C H ED GVIC ++ Q K CG + H++ R+VGG ++ G++PWQ +R K ++ CGA++++ W + AAHC+ R Y +R GD+ +D++E+ ++++++H N+ + + D D AL++++ +G F+ +V P+CLP+ + C +SGWGDT ++Y LL V ++ + C YKG+ T RM CAG +E ID+CQGDSGGPL+C + NG + I G TSWG GC + PGVY K+ WIK+ L Sbjct: 301 NCDHIEDAGVSCDPFTDGALRLSGGARPGEGLVEVYYNGDWGSVCDDGWTELNAQVVCRQLGFSGP--SSLSSKAEFGSGEG-FIFLDDVTCTGEEESLLECPHSSWGQHDCSHSEDVGVRC----------------------------SNESNDIIGIPTGP---PVRLMDGESTKEGRVEVFLNGEWGSVCDDGWTDDDAAVVCRQLGHRGPAKARTMAYFGEGQGPIHMDNVECSGSENTLAECRKQDSGIHNCWHNEDAGVICDYIEKRDNQ-----VKAKGGVSSVCGISLVPHRKKRIVGGTKSARGSWPWQASLRLKGFHKETRLLCGATLINNCWALTAAHCFKRFGKQVHRYSLRVGDYHTGVEDEFERELPLQKIVIHKNYRSTSNDNDIALVRVQGKEGHCFPFSLHVLPICLPEKKEKTNNWQPCFISGWGDTGTSYSRTLLQGAVSVLPKDTCILRYKGKFTNRMVCAGTLFEDRLIDSCQGDSGGPLMCQRSNGQWIIVGITSWGYGCGRKGYPGVYTKVSKFTPWIKKAAKL 809 HSP 2 Score: 153.68 bits (387), Expect = 5.817e-37 Identity = 99/295 (33.56%), Postives = 148/295 (50.17%), Query Frame = 1 Query: 2077 SKKCDHRDNCGDNSDEIDCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICG-LPDEVVTQPPKPTAKV 2958 SK +HR + G + + C++ +RL G +YEG+VEV ++G WG +CDD +D AEV+C+QLGF G ++ A +G+ P +L+DE+ C G E+SL+ C+ S W HNC E AGV C + +DG+ + L+ G G VE+ G G+VCDD + + +A V+CR L G + FG G G I LD++ CTGEE +L CP WG+H C+H ED+GV C ++++ P P ++ Sbjct: 186 SKSLNHRSSHGLIA-AVTCSSSKDSQTPLRLVGGKERYEGRVEVFHEGRWGTICDDHWDDSDAEVICRQLGFSGKPKAWVWA--HYGQGSGP-ILLDEVHCIGNESSLDLCEKSKWEHHNCDHIEDAGVSC-----------------------------DPFTDGA----------LRLSGGARPGEGLVEVYYNGDWGSVCDDGWTELNAQVVCRQLGFSGPSSLSSKAEFGSGEGFIFLDDVTCTGEEESLLECPHSSWGQHDCSHSEDVGVRCSNESNDIIGIPTGPPVRL 437 HSP 3 Score: 102.064 bits (253), Expect = 6.603e-21 Identity = 85/274 (31.02%), Postives = 118/274 (43.07%), Query Frame = 1 Query: 2161 IRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAV--NRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGL 2976 +RL G ++ +G VE+ G+WG +C + + A VVC+QLG + I +A+ R G +P L C G E +L C +S +H IA V C SKD + L G + GRVE+ G GT+CDD +DD DA VICR L G+ +A +G+G+G I+LD + C G E +L+ C KW H C H ED GV C D + + P GL Sbjct: 104 VRLVGDLSFNQGLVELYLNGQWGTICGEQWTDWDASVVCRQLG----VSEIGTALISTRSGSWLAPEHL-QAANCRGNEKALLHCHYSKSLNHRSSHGLIAAVTCS-----------SSKDSQ--------------------------TPLRLVGGKERYEGRVEVFHEGRWGTICDDHWDDSDAEVICRQLGFSGKPKAWVWAHYGQGSGPILLDEVHCIGNESSLDLCEKSKWEHHNCDHIEDAGVSC---DPFTDGALRLSGGARPGEGL 332 HSP 4 Score: 62.7734 bits (151), Expect = 8.427e-9 Identity = 38/98 (38.78%), Postives = 55/98 (56.12%), Query Frame = 1 Query: 343 PESPQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPHDS 636 P + +RL G EG VEVY + WG VCDD W L+A V CRQLGF + +++ + +G G+ + + + CTG E+SL++CPH S Sbjct: 314 PFTDGALRLSG--GARPGEGLVEVYYNGD--WGSVCDDGWTELNAQVVCRQLGFSGPSSLSSKAE-FGSGEGFI---FLDDVTCTGEEESLLECPHSS 403 HSP 5 Score: 58.9214 bits (141), Expect = 1.054e-7 Identity = 41/118 (34.75%), Postives = 60/118 (50.85%), Query Frame = 1 Query: 337 GAPESPQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPHDSTSYCS---GKSAGVSCVY 681 G P P + + GE + EGRVEV+ + WG VCDD W DA V CRQLG R A+ T +G G ++ + ++C+G+E +L +C + + + AGV C Y Sbjct: 428 GIPTGPPVRLMDGE---STKEGRVEVFLNGE--WGSVCDDGWTDDDAAVVCRQLGHRGPAKARTMA-YFGEGQGPIH---MDNVECSGSENTLAECRKQDSGIHNCWHNEDAGVICDY 536 HSP 6 Score: 56.9954 bits (136), Expect = 4.802e-7 Identity = 39/96 (40.62%), Postives = 51/96 (53.12%), Query Frame = 1 Query: 397 EGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPHDSTSY--CSG-KSAGVSC 675 EGRVEV+ WG +CDD+W+ DA V CRQLGF K + A YG+G + + ++ C GNE SL C + C + AGVSC Sbjct: 223 EGRVEVFHEGR--WGTICDDHWDDSDAEVICRQLGFSGKPK-AWVWAHYGQGSGPI---LLDEVHCIGNESSLDLCEKSKWEHHNCDHIEDAGVSC 312 HSP 7 Score: 54.6842 bits (130), Expect = 2.188e-6 Identity = 27/62 (43.55%), Postives = 34/62 (54.84%), Query Frame = 1 Query: 1222 YRGRISRTVQGSSCAKWTDPAATVNPQTNPEAGLGDHNFCRNPDNDLQPWCWTNPTNGVYGY 1407 Y G IS T GS C W + + Q P GLGDHN CRNPD + PWC+ ++GV + Sbjct: 35 YNGTISVTETGSECLHWKEFPDYI--QQYPGRGLGDHNHCRNPDGGVVPWCFYRKSSGVISW 94
BLAST of Neurotrypsin vs. Ensembl Xenopus
Match: ENSXETT00000001537.1 (neurotrypsin-like [Source:NCBI gene;Acc:100497588]) HSP 1 Score: 317.005 bits (811), Expect = 1.167e-90 Identity = 203/548 (37.04%), Postives = 288/548 (52.55%), Query Frame = 1 Query: 2113 NSDEIDCTTVTFPPF---EIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDSHW-CGASILSEDWIIGAAHCYARPKSD---YRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPNSKCLVSGWGDTLSTYPEKLLAAEVPLIKHERCFEFYKGRLTERMQCAG--YEAGGIDTCQGDSGGPLVC-KVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQTGL 3726 N D I+ V+ PF +RL+G EG VEV Y G+WG VCDDG+ A+VVC+QLGF G S S+ FG + +D++ CTG E SL EC HS W H+C E GV C +N+ +D P G V L DG K GRVE+ G G+VCDD + D DAAV+CR L G A+A FGEG G I +DN++C+G E L C G H C H ED GVIC ++ Q K CG + H++ R+VGG ++ G++PWQ +R K ++ CGA++++ W + AAHC+ R Y +R GD+ +D++E+ ++++++H N+ + + D D AL++++ +G F+ +V P+CLP+ + C +SGWGDT ++Y LL V ++ + C YKG+ T RM CAG +E ID+CQGDSGGPL+C + NG + I G TSWG GC + PGVY K+ WIK+ L Sbjct: 320 NCDHIEDAGVSCDPFTDGALRLSGGARPGEGLVEVYYNGDWGSVCDDGWTELNAQVVCRQLGFSGP--SSLSSKAEFGSGEG-FIFLDDVTCTGEEESLLECPHSSWGQHDCSHSEDVGVRC----------------------------SNESNDIIGIPTGP---PVRLMDGESTKEGRVEVFLNGEWGSVCDDGWTDDDAAVVCRQLGHRGPAKARTMAYFGEGQGPIHMDNVECSGSENTLAECRKQDSGIHNCWHNEDAGVICDYIEKRDNQ-----VKAKGGVSSVCGISLVPHRKKRIVGGTKSARGSWPWQASLRLKGFHKETRLLCGATLINNCWALTAAHCFKRFGKQVHRYSLRVGDYHTGVEDEFERELPLQKIVIHKNYRSTSNDNDIALVRVQGKEGHCFPFSLHVLPICLPEKKEKTNNWQPCFISGWGDTGTSYSRTLLQGAVSVLPKDTCILRYKGKFTNRMVCAGTLFEDRLIDSCQGDSGGPLMCQRSNGQWIIVGITSWGYGCGRKGYPGVYTKVSKFTPWIKKAAKL 828 HSP 2 Score: 153.68 bits (387), Expect = 7.244e-37 Identity = 99/295 (33.56%), Postives = 148/295 (50.17%), Query Frame = 1 Query: 2077 SKKCDHRDNCGDNSDEIDCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICG-LPDEVVTQPPKPTAKV 2958 SK +HR + G + + C++ +RL G +YEG+VEV ++G WG +CDD +D AEV+C+QLGF G ++ A +G+ P +L+DE+ C G E+SL+ C+ S W HNC E AGV C + +DG+ + L+ G G VE+ G G+VCDD + + +A V+CR L G + FG G G I LD++ CTGEE +L CP WG+H C+H ED+GV C ++++ P P ++ Sbjct: 205 SKSLNHRSSHGLIA-AVTCSSSKDSQTPLRLVGGKERYEGRVEVFHEGRWGTICDDHWDDSDAEVICRQLGFSGKPKAWVWA--HYGQGSGP-ILLDEVHCIGNESSLDLCEKSKWEHHNCDHIEDAGVSC-----------------------------DPFTDGA----------LRLSGGARPGEGLVEVYYNGDWGSVCDDGWTELNAQVVCRQLGFSGPSSLSSKAEFGSGEGFIFLDDVTCTGEEESLLECPHSSWGQHDCSHSEDVGVRCSNESNDIIGIPTGPPVRL 456 HSP 3 Score: 102.064 bits (253), Expect = 7.986e-21 Identity = 87/274 (31.75%), Postives = 120/274 (43.80%), Query Frame = 1 Query: 2161 IRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAV--NRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGL 2976 +RL G ++ +G VE+ G+WG +C + + A VVC+QLG + I +A+ R G +P L C G E +L C +S +H IA V C SKD S P + L G + GRVE+ G GT+CDD +DD DA VICR L G+ +A +G+G+G I+LD + C G E +L+ C KW H C H ED GV C D + + P GL Sbjct: 123 VRLVGDLSFNQGLVELYLNGQWGTICGEQWTDWDASVVCRQLG----VSEIGTALISTRSGSWLAPEHL-QAANCRGNEKALLHCHYSKSLNHRSSHGLIAAVTCS-----------SSKD-------------------SQTP-------LRLVGGKERYEGRVEVFHEGRWGTICDDHWDDSDAEVICRQLGFSGKPKAWVWAHYGQGSGPILLDEVHCIGNESSLDLCEKSKWEHHNCDHIEDAGVSC---DPFTDGALRLSGGARPGEGL 351 HSP 4 Score: 62.7734 bits (151), Expect = 7.693e-9 Identity = 38/98 (38.78%), Postives = 55/98 (56.12%), Query Frame = 1 Query: 343 PESPQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPHDS 636 P + +RL G EG VEVY + WG VCDD W L+A V CRQLGF + +++ + +G G+ + + + CTG E+SL++CPH S Sbjct: 333 PFTDGALRLSG--GARPGEGLVEVYYNGD--WGSVCDDGWTELNAQVVCRQLGFSGPSSLSSKAE-FGSGEGFI---FLDDVTCTGEEESLLECPHSS 422 HSP 5 Score: 59.3066 bits (142), Expect = 9.133e-8 Identity = 41/118 (34.75%), Postives = 60/118 (50.85%), Query Frame = 1 Query: 337 GAPESPQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPHDSTSYCS---GKSAGVSCVY 681 G P P + + GE + EGRVEV+ + WG VCDD W DA V CRQLG R A+ T +G G ++ + ++C+G+E +L +C + + + AGV C Y Sbjct: 447 GIPTGPPVRLMDGE---STKEGRVEVFLNGE--WGSVCDDGWTDDDAAVVCRQLGHRGPAKARTMA-YFGEGQGPIH---MDNVECSGSENTLAECRKQDSGIHNCWHNEDAGVICDY 555 HSP 6 Score: 56.9954 bits (136), Expect = 4.490e-7 Identity = 39/96 (40.62%), Postives = 51/96 (53.12%), Query Frame = 1 Query: 397 EGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPHDSTSY--CSG-KSAGVSC 675 EGRVEV+ WG +CDD+W+ DA V CRQLGF K + A YG+G + + ++ C GNE SL C + C + AGVSC Sbjct: 242 EGRVEVFHEGR--WGTICDDHWDDSDAEVICRQLGFSGKPK-AWVWAHYGQGSGPI---LLDEVHCIGNESSLDLCEKSKWEHHNCDHIEDAGVSC 331 HSP 7 Score: 55.0694 bits (131), Expect = 1.785e-6 Identity = 27/62 (43.55%), Postives = 34/62 (54.84%), Query Frame = 1 Query: 1222 YRGRISRTVQGSSCAKWTDPAATVNPQTNPEAGLGDHNFCRNPDNDLQPWCWTNPTNGVYGY 1407 Y G IS T GS C W + + Q P GLGDHN CRNPD + PWC+ ++GV + Sbjct: 54 YNGTISVTETGSECLHWKEFPDYI--QQYPGRGLGDHNHCRNPDGGVVPWCFYRKSSGVISW 113
BLAST of Neurotrypsin vs. Ensembl Xenopus
Match: ENSXETT00000001485.1 (neurotrypsin-like [Source:NCBI gene;Acc:100497588]) HSP 1 Score: 315.464 bits (807), Expect = 2.819e-90 Identity = 202/548 (36.86%), Postives = 287/548 (52.37%), Query Frame = 1 Query: 2113 NSDEIDCTTVTFPPF---EIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDSHW-CGASILSEDWIIGAAHCYARPKSD---YRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPNSKCLVSGWGDTLSTYPEKLLAAEVPLIKHERCFEFYKGRLTERMQCAG--YEAGGIDTCQGDSGGPLVC-KVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQTGL 3726 N D I+ V+ PF +RL+G EG VEV Y G+WG VCDDG+ A+VVC+QLGF G S S+ FG + +D++ CTG E SL EC HS W H+C E GV C +N+ +D P V L DG K GRVE+ G G+VCDD + D DAAV+CR L G A+A FGEG G I +DN++C+G E L C G H C H ED GVIC ++ Q K CG + H++ R+VGG ++ G++PWQ +R K ++ CGA++++ W + AAHC+ R Y +R GD+ +D++E+ ++++++H N+ + + D D AL++++ +G F+ +V P+CLP+ + C +SGWGDT ++Y LL V ++ + C YKG+ T RM CAG +E ID+CQGDSGGPL+C + NG + I G TSWG GC + PGVY K+ WIK+ L Sbjct: 309 NCDHIEDAGVSCDPFTDGALRLSGGARPGEGLVEVYYNGDWGSVCDDGWTELNAQVVCRQLGFSGP--SSLSSKAEFGSGEG-FIFLDDVTCTGEEESLLECPHSSWGQHDCSHSEDVGVRC----------------------------SNESNDIIGPP-------VRLMDGESTKEGRVEVFLNGEWGSVCDDGWTDDDAAVVCRQLGHRGPAKARTMAYFGEGQGPIHMDNVECSGSENTLAECRKQDSGIHNCWHNEDAGVICDYIEKRDNQ-----VKAKGGVSSVCGISLVPHRKKRIVGGTKSARGSWPWQASLRLKGFHKETRLLCGATLINNCWALTAAHCFKRFGKQVHRYSLRVGDYHTGVEDEFERELPLQKIVIHKNYRSTSNDNDIALVRVQGKEGHCFPFSLHVLPICLPEKKEKTNNWQPCFISGWGDTGTSYSRTLLQGAVSVLPKDTCILRYKGKFTNRMVCAGTLFEDRLIDSCQGDSGGPLMCQRSNGQWIIVGITSWGYGCGRKGYPGVYTKVSKFTPWIKKAAKL 813 HSP 2 Score: 154.451 bits (389), Expect = 3.484e-37 Identity = 99/288 (34.38%), Postives = 143/288 (49.65%), Query Frame = 1 Query: 2077 SKKCDHRDNCGDNSDEIDCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPP 2940 SK +HR + G + + C++ +RL G +YEG+VEV ++G WG +CDD +D AEV+C+QLGF G ++ A +G+ P +L+DE+ C G E+SL+ C+ S W HNC E AGV C + +DG+ + L+ G G VE+ G G+VCDD + + +A V+CR L G + FG G G I LD++ CTGEE +L CP WG+H C+H ED+GV C + PP Sbjct: 194 SKSLNHRSSHGLIA-AVTCSSSKDSQTPLRLVGGKERYEGRVEVFHEGRWGTICDDHWDDSDAEVICRQLGFSGKPKAWVWA--HYGQGSGP-ILLDEVHCIGNESSLDLCEKSKWEHHNCDHIEDAGVSC-----------------------------DPFTDGA----------LRLSGGARPGEGLVEVYYNGDWGSVCDDGWTELNAQVVCRQLGFSGPSSLSSKAEFGSGEGFIFLDDVTCTGEEESLLECPHSSWGQHDCSHSEDVGVRCSNESNDIIGPP 438 HSP 3 Score: 102.064 bits (253), Expect = 6.421e-21 Identity = 87/274 (31.75%), Postives = 120/274 (43.80%), Query Frame = 1 Query: 2161 IRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAV--NRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGL 2976 +RL G ++ +G VE+ G+WG +C + + A VVC+QLG + I +A+ R G +P L C G E +L C +S +H IA V C SKD S P + L G + GRVE+ G GT+CDD +DD DA VICR L G+ +A +G+G+G I+LD + C G E +L+ C KW H C H ED GV C D + + P GL Sbjct: 112 VRLVGDLSFNQGLVELYLNGQWGTICGEQWTDWDASVVCRQLG----VSEIGTALISTRSGSWLAPEHL-QAANCRGNEKALLHCHYSKSLNHRSSHGLIAAVTCSS-----------SKD-------------------SQTP-------LRLVGGKERYEGRVEVFHEGRWGTICDDHWDDSDAEVICRQLGFSGKPKAWVWAHYGQGSGPILLDEVHCIGNESSLDLCEKSKWEHHNCDHIEDAGVSC---DPFTDGALRLSGGARPGEGL 340 HSP 4 Score: 62.7734 bits (151), Expect = 7.438e-9 Identity = 38/98 (38.78%), Postives = 55/98 (56.12%), Query Frame = 1 Query: 343 PESPQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPHDS 636 P + +RL G EG VEVY + WG VCDD W L+A V CRQLGF + +++ + +G G+ + + + CTG E+SL++CPH S Sbjct: 322 PFTDGALRLSG--GARPGEGLVEVYYNGD--WGSVCDDGWTELNAQVVCRQLGFSGPSSLSSKAE-FGSGEGFI---FLDDVTCTGEEESLLECPHSS 411 HSP 5 Score: 56.9954 bits (136), Expect = 4.811e-7 Identity = 39/96 (40.62%), Postives = 51/96 (53.12%), Query Frame = 1 Query: 397 EGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPHDSTSY--CSG-KSAGVSC 675 EGRVEV+ WG +CDD+W+ DA V CRQLGF K + A YG+G + + ++ C GNE SL C + C + AGVSC Sbjct: 231 EGRVEVFHEGR--WGTICDDHWDDSDAEVICRQLGFSGKPK-AWVWAHYGQGSGPI---LLDEVHCIGNESSLDLCEKSKWEHHNCDHIEDAGVSC 320 HSP 6 Score: 55.0694 bits (131), Expect = 1.549e-6 Identity = 33/91 (36.26%), Postives = 45/91 (49.45%), Query Frame = 1 Query: 1147 EKLPFICQMNIPQSRSDCYEDNGLD----YRGRISRTVQGSSCAKWTDPAATVNPQTNPEAGLGDHNFCRNPDNDLQPWCWTNPTNGVYGY 1407 + L C + + S C +G+D Y G IS T GS C W + + Q P GLGDHN CRNPD + PWC+ ++GV + Sbjct: 16 QLLKSCCMLFLLAGYSLC--SDGIDSLGYYNGTISVTETGSECLHWKEFPDYI--QQYPGRGLGDHNHCRNPDGGVVPWCFYRKSSGVISW 102 HSP 7 Score: 55.0694 bits (131), Expect = 1.947e-6 Identity = 39/113 (34.51%), Postives = 58/113 (51.33%), Query Frame = 1 Query: 352 PQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPHDSTSYCS---GKSAGVSCVY 681 P + + GE + EGRVEV+ + WG VCDD W DA V CRQLG R A+ T +G G ++ + ++C+G+E +L +C + + + AGV C Y Sbjct: 437 PPVRLMDGE---STKEGRVEVFLNGE--WGSVCDDGWTDDDAAVVCRQLGHRGPAKARTMA-YFGEGQGPIH---MDNVECSGSENTLAECRKQDSGIHNCWHNEDAGVICDY 540
BLAST of Neurotrypsin vs. Ensembl Xenopus
Match: tmem132a (transmembrane protein 132A [Source:Xenbase;Acc:XB-GENE-1009879]) HSP 1 Score: 287.345 bits (734), Expect = 2.402e-81 Identity = 192/551 (34.85%), Postives = 279/551 (50.64%), Query Frame = 1 Query: 2101 NCGDNSDE-IDCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDSH-WCGASILSEDWIIGAAHCYARPKSD---YRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPN-SKCLVSGWGDTLSTYPEKLLAAEVPLIKHERCFEFYKGRLTERMQCAGY--EAGGIDTCQGDSGGPLVC-KVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQTGL 3726 NCG D + CT + IRL G +EG++EV ++ WG VCDDG+ +VVC+QLG+ + N + + + + +D+I CTG E+ + +C W H+C E + C D ++T+ G + L DG K GRVE+ G GT+CDD + DKDA+V+CR L G A+A FGEG G I +DN++CTG E +L +C G H C H ED GVIC D ++ + K + L CG R + R++GG +V G +PWQV +R K D CGA+++S W++ AAHC+ R ++ Y +R GD+ ++YE+ I+++I+H ++ DYD ALI++ ++ + +V P CLP P S C ++GWGDT Y L A V L+ C E Y+ + T RM CAG +D+CQGDSGGPLVC + G + ++G TSWG GC +PGVY K+ + WIK T L Sbjct: 237 NCGHKEDAGVSCTPLA--DGAIRLAGGKGSHEGRLEVFHKARWGTVCDDGWTDLNTQVVCRQLGYKNGKILLE---NHYAGS-AGVIWLDDISCTGKESMISQCSRRDWGKHDCSHQEDVHIACHPD-----------------------NETHRPLSGP---------PLRLMDGETKKEGRVEIYLNGQWGTICDDGWTDKDASVVCRQLGYKGPAKARTMAYFGEGKGPIHVDNVRCTGYERSLADCIKQDIGTHNCRHSEDAGVIC---DYIIKKSTFAANK--ELSPLVCGSRLQHRRPKRIIGGKNSVRGGWPWQVALRLKSSHGDGRLLCGATLISSCWVLTAAHCFKRYGNNTRSYVIRVGDYHTLVPEEYEEDMTIQQIIIHNDYRPDGNDYDIALIRLHGTAEQCVQLSTHVLPACLPLRRERPQKTASNCYITGWGDTGRAYSRTLQQATVTLLPKRVCEERYRSQFTGRMLCAGSVKTQKHVDSCQGDSGGPLVCERSGGSWIVYGVTSWGYGCGVKDSPGVYTKVSAFIPWIKSVTNL 744 HSP 2 Score: 139.428 bits (350), Expect = 1.147e-32 Identity = 90/258 (34.88%), Postives = 129/258 (50.00%), Query Frame = 1 Query: 2164 RLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQP 2937 RL G + YEG++EV + G WG VCDD +D AEVVC+QLG+ G ++ A FG+ +L+DE++CTG E S+EEC+ SPW HNC E AGV C +DG+ + LA G + GR+E+ GTVCDD + D + V+CR L + + + + AG I LD++ CTG+E + C WG+H C+H+ED+ + C PD +P Sbjct: 150 RLVGGSSPYEGRIEVYHSGHWGTVCDDQWDDADAEVVCRQLGYGGVAKAWSQA--HFGEGVG-FILLDEVQCTGNELSIEECQRSPWGEHNCGHKEDAGVSC-----------------------------TPLADGA----------IRLAGGKGSHEGRLEVFHKARWGTVCDDGWTDLNTQVVCRQLGYK-NGKILLENHYAGSAGVIWLDDISCTGKESMISQCSRRDWGKHDCSHQEDVHIAC-HPDNETHRP 363 HSP 3 Score: 88.9669 bits (219), Expect = 6.095e-17 Identity = 50/102 (49.02%), Postives = 61/102 (59.80%), Query Frame = 1 Query: 2602 VKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVIC 2907 + L G GR+E+ G GTVCDD +DD DA V+CR L G A+A FGEG G I+LD ++CTG EL++E C WGEH C HKED GV C Sbjct: 147 IPARLVGGSSPYEGRIEVYHSGHWGTVCDDQWDDADAEVVCRQLGYGGVAKAWSQAHFGEGVGFILLDEVQCTGNELSIEECQRSPWGEHNCGHKEDAGVSC 248 HSP 4 Score: 67.781 bits (164), Expect = 2.419e-10 Identity = 52/168 (30.95%), Postives = 74/168 (44.05%), Query Frame = 1 Query: 397 EGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDC---PHDSTSYCSGKSAGVSCV---------------------------YNLGCPNGWISFNGACYQINTQQMDYKQADKFCQDHNSKLAFIL 810 EGR+EVY S WG VCDD W+ DA V CRQLG+ A+ A Q +G G V + ++QCTGNE S+ +C P + + AGVSC + C +GW N Q+ +Q+ YK ++H + A ++ Sbjct: 159 EGRIEVYHSGH--WGTVCDDQWDDADAEVVCRQLGYGGVAK-AWSQAHFGEG---VGFILLDEVQCTGNELSIEECQRSPWGEHNCGHKEDAGVSCTPLADGAIRLAGGKGSHEGRLEVFHKARWGTVCDDGWTDLN---TQVVCRQLGYKNGKILLENHYAGSAGVI 317 HSP 5 Score: 63.929 bits (154), Expect = 3.515e-9 Identity = 43/108 (39.81%), Postives = 58/108 (53.70%), Query Frame = 1 Query: 367 LRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPHD--STSYC-SGKSAGVSCVY 681 LR + T EGRVE+Y + WG +CDD W DA+V CRQLG++ A+ T +G G ++ V ++CTG E+SL DC T C + AGV C Y Sbjct: 369 LRLMDGETKKEGRVEIYLNGQ--WGTICDDGWTDKDASVVCRQLGYKGPAKART-MAYFGEGKGPIH---VDNVRCTGYERSLADCIKQDIGTHNCRHSEDAGVICDY 470
BLAST of Neurotrypsin vs. Ensembl Xenopus
Match: tmem132a (transmembrane protein 132A [Source:Xenbase;Acc:XB-GENE-1009879]) HSP 1 Score: 287.345 bits (734), Expect = 1.749e-80 Identity = 192/551 (34.85%), Postives = 279/551 (50.64%), Query Frame = 1 Query: 2101 NCGDNSDE-IDCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDSH-WCGASILSEDWIIGAAHCYARPKSD---YRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPN-SKCLVSGWGDTLSTYPEKLLAAEVPLIKHERCFEFYKGRLTERMQCAGY--EAGGIDTCQGDSGGPLVC-KVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQTGL 3726 NCG D + CT + IRL G +EG++EV ++ WG VCDDG+ +VVC+QLG+ + N + + + + +D+I CTG E+ + +C W H+C E + C D ++T+ G + L DG K GRVE+ G GT+CDD + DKDA+V+CR L G A+A FGEG G I +DN++CTG E +L +C G H C H ED GVIC D ++ + K + L CG R + R++GG +V G +PWQV +R K D CGA+++S W++ AAHC+ R ++ Y +R GD+ ++YE+ I+++I+H ++ DYD ALI++ ++ + +V P CLP P S C ++GWGDT Y L A V L+ C E Y+ + T RM CAG +D+CQGDSGGPLVC + G + ++G TSWG GC +PGVY K+ + WIK T L Sbjct: 344 NCGHKEDAGVSCTPLA--DGAIRLAGGKGSHEGRLEVFHKARWGTVCDDGWTDLNTQVVCRQLGYKNGKILLE---NHYAGS-AGVIWLDDISCTGKESMISQCSRRDWGKHDCSHQEDVHIACHPD-----------------------NETHRPLSGP---------PLRLMDGETKKEGRVEIYLNGQWGTICDDGWTDKDASVVCRQLGYKGPAKARTMAYFGEGKGPIHVDNVRCTGYERSLADCIKQDIGTHNCRHSEDAGVIC---DYIIKKSTFAANK--ELSPLVCGSRLQHRRPKRIIGGKNSVRGGWPWQVALRLKSSHGDGRLLCGATLISSCWVLTAAHCFKRYGNNTRSYVIRVGDYHTLVPEEYEEDMTIQQIIIHNDYRPDGNDYDIALIRLHGTAEQCVQLSTHVLPACLPLRRERPQKTASNCYITGWGDTGRAYSRTLQQATVTLLPKRVCEERYRSQFTGRMLCAGSVKTQKHVDSCQGDSGGPLVCERSGGSWIVYGVTSWGYGCGVKDSPGVYTKVSAFIPWIKSVTNL 851 HSP 2 Score: 124.02 bits (310), Expect = 1.203e-27 Identity = 91/267 (34.08%), Postives = 121/267 (45.32%), Query Frame = 1 Query: 2110 DNSDEIDCTTVTFPPFEIRLTGSVNKYEGKV-EVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVIC 2907 +N ID +RL GS +K EG V EV G WG +C +D A V+C+QL + ++ G+ + +++C G E ++ +C WRS C D A V C V +A KD + I L G GR+E+ G GTVCDD +DD DA V+CR L G A+A FGEG G I+LD ++CTG EL++E C WGEH C HKED GV C Sbjct: 126 NNHGRIDWGYCDCKQGSVRLRGSKSKSEGSVVEVYVNGAWGTICSGQWDDNDASVICRQLELGDKGTAKKIVLSGVGQ---ISAFWTDVQCRGNEENILQCAKDIWRSGACPQDTAAAVTCSVIQA---------KDSVFI-------------------------PARLVGGSSPYEGRIEVYHSGHWGTVCDDQWDDADAEVVCRQLGYGGVAKAWSQAHFGEGVGFILLDEVQCTGNELSIEECQRSPWGEHNCGHKEDAGVSC 355 HSP 3 Score: 67.781 bits (164), Expect = 2.312e-10 Identity = 52/168 (30.95%), Postives = 74/168 (44.05%), Query Frame = 1 Query: 397 EGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDC---PHDSTSYCSGKSAGVSCV---------------------------YNLGCPNGWISFNGACYQINTQQMDYKQADKFCQDHNSKLAFIL 810 EGR+EVY S WG VCDD W+ DA V CRQLG+ A+ A Q +G G V + ++QCTGNE S+ +C P + + AGVSC + C +GW N Q+ +Q+ YK ++H + A ++ Sbjct: 266 EGRIEVYHSGH--WGTVCDDQWDDADAEVVCRQLGYGGVAK-AWSQAHFGEG---VGFILLDEVQCTGNELSIEECQRSPWGEHNCGHKEDAGVSCTPLADGAIRLAGGKGSHEGRLEVFHKARWGTVCDDGWTDLN---TQVVCRQLGYKNGKILLENHYAGSAGVI 424 HSP 4 Score: 63.5438 bits (153), Expect = 4.123e-9 Identity = 43/108 (39.81%), Postives = 58/108 (53.70%), Query Frame = 1 Query: 367 LRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPHD--STSYC-SGKSAGVSCVY 681 LR + T EGRVE+Y + WG +CDD W DA+V CRQLG++ A+ T +G G ++ V ++CTG E+SL DC T C + AGV C Y Sbjct: 476 LRLMDGETKKEGRVEIYLNGQ--WGTICDDGWTDKDASVVCRQLGYKGPAKART-MAYFGEGKGPIH---VDNVRCTGYERSLADCIKQDIGTHNCRHSEDAGVICDY 577
BLAST of Neurotrypsin vs. Ensembl Mouse
Match: Prss12 (protease, serine 12 neurotrypsin (motopsin) [Source:MGI Symbol;Acc:MGI:1100881]) HSP 1 Score: 302.753 bits (774), Expect = 1.507e-86 Identity = 211/593 (35.58%), Postives = 300/593 (50.59%), Query Frame = 1 Query: 1984 IAITYPGAHYSMKSD-CTAEQFKCTRG-MCIELSKKCDHRD-NCGDNSDE-IDCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDSH-WCGASILSEDWIIGAAHCYARPKSD---YRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPN-SKCLVSGWGDTLSTYPEKLLAAEVPLIKHERCFEFYKGRLTERMQCAG--YEAGGIDTCQGDSGGPLVC-KVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQTGL 3726 IA + AH+ S ++ +CT + IE K + NCG D + C +T IRL G + +EG++EV Y+G+WG VCDDG+ V C+ LGF +S +VN F + P + +D++ C+G E S +C W H+C E G+ C D SDG G + L DG + K GRVE+ G GT+CDD + DK AAVICR L G A+A FGEG G I +DN+KCTG E L +C G H C H ED GVIC D + + K ++G CG R + ++ R++GG ++ GA+PWQ +R + D CGA++LS W++ AAHC+ R ++ Y VR GD+ +++EQ ++++++H N+ DYD AL++++ + + +V P CLP P S C ++GWGDT Y L A VPL+ C E YKG T RM CAG E +D+CQGDSGGPL+C K + + ++G TSWG GC PGVY ++ + WIK T L Sbjct: 212 IAKAWHQAHFGEGSGPILLDEVRCTGNELSIEQCPKSSWGEHNCGHKEDAGVSCVPLT--DGVIRLAGGKSTHEGRLEVYYKGQWGTVCDDGWTEMNTYVACRLLGFKYGKQS---SVNHFDGSNRP-IWLDDVSCSGKEVSFIQCSRRQWGRHDCSHREDVGLTCYPD-----------------------------SDGHRLSPG---FPIRLVDGENKKEGRVEVFVNGQWGTICDDGWTDKHAAVICRQLGYKGPARARTMAYFGEGKGPIHMDNVKCTGNEKALADCVKQDIGRHNCRHSEDAGVIC---DYLEKKASSSGNKEMLSSG--CGLRLLHRRQKRIIGGNNSLRGAWPWQASLRLRSAHGDGRLLCGATLLSSCWVLTAAHCFKRYGNNSRSYAVRVGDYHTLVPEEFEQEIGVQQIVIHRNYRPDRSDYDIALVRLQGPGEQCARLSTHVLPACLPLWRERPQKTASNCHITGWGDTGRAYSRTLQQAAVPLLPKRFCKERYKGLFTGRMLCAGNLQEDNRVDSCQGDSGGPLMCEKPDESWVVYGVTSWGYGCGVKDTPGVYTRVPAFVPWIKSVTSL 761 HSP 2 Score: 132.88 bits (333), Expect = 1.238e-30 Identity = 87/254 (34.25%), Postives = 129/254 (50.79%), Query Frame = 1 Query: 2161 IRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDE 2922 IRL G + +EG+VE+ + G+WG +CDD +D A+V+C+QLG G ++ H A FG+ P +L+DE++CTG E S+E+C S W HNC E AGV C+ L +DG + LA G GR+E+ G GTVCDD + + + V CR+L Q+ + F I LD++ C+G+E++ C +WG H C+H+ED+G+ C PD Sbjct: 166 IRLVGGNSGHEGRVELYHAGQWGTICDDQWDNADADVICRQLGLSGIAKAWHQA--HFGEGSGP-ILLDEVRCTGNELSIEQCPKSSWGEHNCGHKEDAGV-------------------SCVPL----------TDGV----------IRLAGGKSTHEGRLEVYYKGQWGTVCDDGWTEMNTYVACRLLGFKYGKQSSVN-HFDGSNRPIWLDDVSCSGKEVSFIQCSRRQWGRHDCSHREDVGLTC-YPDS 375 HSP 3 Score: 98.2117 bits (243), Expect = 8.225e-20 Identity = 53/107 (49.53%), Postives = 66/107 (61.68%), Query Frame = 1 Query: 2587 EGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVIC 2907 +G + L G GRVEL G GT+CDD +D+ DA VICR L + G A+A FGEG+G I+LD ++CTG EL++E CP WGEH C HKED GV C Sbjct: 159 QGPALPVIRLVGGNSGHEGRVELYHAGQWGTICDDQWDNADADVICRQLGLSGIAKAWHQAHFGEGSGPILLDEVRCTGNELSIEQCPKSSWGEHNCGHKEDAGVSC 265 HSP 4 Score: 73.559 bits (179), Expect = 3.010e-12 Identity = 49/116 (42.24%), Postives = 65/116 (56.03%), Query Frame = 1 Query: 340 APESPQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPHDS--TSYCSGKS-AGVSCV 678 P P +IRL G N + +EGRVE+Y + WG +CDD W+ DA+V CRQLG A+ A Q +G G + + +++CTGNE S+ CP S C K AGVSCV Sbjct: 160 GPALP-VIRLVGGN--SGHEGRVELYHAGQ--WGTICDDQWDNADADVICRQLGLSGIAK-AWHQAHFGEGSGPI---LLDEVRCTGNELSIEQCPKSSWGEHNCGHKEDAGVSCV 266 HSP 5 Score: 62.3882 bits (150), Expect = 7.590e-9 Identity = 43/99 (43.43%), Postives = 55/99 (55.56%), Query Frame = 1 Query: 334 DGAPESPQI-IRL-RGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDC 624 DG SP IRL GEN EGRVEV+ + WG +CDD W A V CRQLG++ AR T +G G ++ + ++CTGNEK+L DC Sbjct: 376 DGHRLSPGFPIRLVDGENK---KEGRVEVFVNGQ--WGTICDDGWTDKHAAVICRQLGYKGPARART-MAYFGEGKGPIH---MDNVKCTGNEKALADC 465
BLAST of Neurotrypsin vs. Ensembl Mouse
Match: Tmprss2 (transmembrane protease, serine 2 [Source:MGI Symbol;Acc:MGI:1354381]) HSP 1 Score: 176.407 bits (446), Expect = 2.782e-46 Identity = 134/425 (31.53%), Postives = 203/425 (47.76%), Query Frame = 1 Query: 2476 DRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKG--TVCXXXXXXXXAAVICRMLQIPGR---AQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDSHWCGASILSEDWIIGAAHCYARPKSDYRVRTGDWD--NASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPNSKCLVSGWGDTLST--YPEKLLAAEVPLIKHERCFE--FYKGRLTERMQCAGYEAGGIDTCQGDSGGPLVCKVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQ 3717 D C+ SE C CIS S CD C +G DE +C V++ +S +++ K VC DD+ + C+ + +Q I D+ +GA L + ++L + C+ + + + C ++CG R V ++ R+VGG A G +PWQV + + H CG SI++ +WI+ AAHC P S R T S Y ++E++I HPN+++ + D AL+K++ + FN+ V+PVCLP GM+ D + +C +SGWG T + L AA VPLI+ +C Y +T M CAG+ G +D+CQGDSGGPLV NG++ + G TSWG+GCA+ PGVY + + DWI +Q Sbjct: 109 DSNCSTSEMECGSSGTCISSSLWCDGVAHCPNGEDE--NRC-VRLY------GQSFILQVYSSQRKAWYPVCQDDWSESYGRAACKDMGYKNNFYSSQGIPDQ-----SGATSFMKLNVSSGNVDLYKKLYH---SDSCSSRMVVSLRC----------------------IECGVRS-VKRQSRIVGGLNASPGDWPWQVSLHVQ----GVHVCGGSIITPEWIVTAAHCVEEPLSSPRYWTAFAGILRQSLMFYGSRHQVEKVISHPNYDSKTKNNDIALMKLQ----TPLAFNDLVKPVCLPNPGMMLDLDQECWISGWGATYEKGKTSDVLNAAMVPLIEPSKCNSKYIYNNLITPAMICAGFLQGSVDSCQGDSGGPLVTLKNGIWWLIGDTSWGSGCAKALRPGVYGNVTVFTDWIYQQ 485
BLAST of Neurotrypsin vs. Ensembl Mouse
Match: Tmprss15 (transmembrane protease, serine 15 [Source:MGI Symbol;Acc:MGI:1197523]) HSP 1 Score: 184.111 bits (466), Expect = 4.035e-46 Identity = 132/446 (29.60%), Postives = 217/446 (48.65%), Query Frame = 1 Query: 2425 RSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGA---------GAIVLD-NLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDSHWCGASILSEDWIIGAAHCYARPKSDYRVRTG--DWDNASDDKYEQVFE--IEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPNSKCLVSGWG-DTLS--TYPEKLLAAEVPLIKHERCFE-FYKGRLTERMQCAGYEAGGIDTCQGDSGGPLVCKVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWI 3708 R + + +G + C + EF+C KD CI L +CD C DGSDE C V +G + +G V+ + + C +++ + + +C +L + ++ G G G+++L +L+C+ + L L +C HK CG K T KV P ++VGG +A GA+PW V + + D CGAS++S DW++ AAHC R D T S+ QV +++++++P+++ D A++ +E + + +Y+QP+CLP+ + P C ++GWG D ++ + + L A+VPLI +E+C + + +TE M CAGYE GGID+CQGDSGGPL+C+ N + + G TS+G CA P +PGVY ++ ++WI Sbjct: 668 RRKGFKANFTSGYYLGIPEPCQDDEFQC-KDGNCIPLGNLCDSYPHCRDGSDE--ASC---VRFLNGTRSNNGLVQFNIHSIWHIACAENWTTQISNEVCHLLGLGSANSSMPISSTGGGPFVRVNQAPNGSLILTPSLQCSQDSLIL----------LQCNHKS-----CG--------EKKVTQKVSP----------------KIVGGSDAQAGAWPWVVALYHRDRSTDRLLCGASLVSSDWLVSAAHCVYRRNLDPTRWTAVLGLHMQSNLTSPQVVRRVVDQIVINPHYDRRRKVNDIAMMHLE----FKVNYTDYIQPICLPEENQIFIPGRTCSIAGWGYDKINAGSTVDVLKEADVPLISNEKCQQQLPEYNITESMICAGYEEGGIDSCQGDSGGPLMCQENNRWFLVGVTSFGVQCALPNHPGVYVRVSQFIEWI 1064 HSP 2 Score: 52.7582 bits (125), Expect = 7.453e-6 Identity = 36/145 (24.83%), Postives = 57/145 (39.31%), Query Frame = 1 Query: 2002 GAHYSMKSDCTAEQFKCTRGMCIELSKKCDHRDNCGDNSDEIDCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGK----NRSPN---LLVDEIKCTGTENSLEECKH 2415 G + + C ++F+C G CI L CD +C D SDE C +R G V+ W C + + + + VC LG A S+ + G N++PN +L ++C+ L +C H Sbjct: 679 GYYLGIPEPCQDDEFQCKDGNCIPLGNLCDSYPHCRDGSDEASC---------VRFLNGTRSNNGLVQFNIHSIWHIACAENWTTQISNEVCHLLGLGSANSSMPISSTGGGPFVRVNQAPNGSLILTPSLQCSQDSLILLQCNH 814
BLAST of Neurotrypsin vs. Ensembl Mouse
Match: Tmprss15 (transmembrane protease, serine 15 [Source:MGI Symbol;Acc:MGI:1197523]) HSP 1 Score: 183.726 bits (465), Expect = 4.721e-46 Identity = 132/446 (29.60%), Postives = 217/446 (48.65%), Query Frame = 1 Query: 2425 RSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGA---------GAIVLD-NLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDSHWCGASILSEDWIIGAAHCYARPKSDYRVRTG--DWDNASDDKYEQVFE--IEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPNSKCLVSGWG-DTLS--TYPEKLLAAEVPLIKHERCFE-FYKGRLTERMQCAGYEAGGIDTCQGDSGGPLVCKVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWI 3708 R + + +G + C + EF+C KD CI L +CD C DGSDE C V +G + +G V+ + + C +++ + + +C +L + ++ G G G+++L +L+C+ + L L +C HK CG K T KV P ++VGG +A GA+PW V + + D CGAS++S DW++ AAHC R D T S+ QV +++++++P+++ D A++ +E + + +Y+QP+CLP+ + P C ++GWG D ++ + + L A+VPLI +E+C + + +TE M CAGYE GGID+CQGDSGGPL+C+ N + + G TS+G CA P +PGVY ++ ++WI Sbjct: 653 RRKGFKANFTSGYYLGIPEPCQDDEFQC-KDGNCIPLGNLCDSYPHCRDGSDE--ASC---VRFLNGTRSNNGLVQFNIHSIWHIACAENWTTQISNEVCHLLGLGSANSSMPISSTGGGPFVRVNQAPNGSLILTPSLQCSQDSLIL----------LQCNHKS-----CG--------EKKVTQKVSP----------------KIVGGSDAQAGAWPWVVALYHRDRSTDRLLCGASLVSSDWLVSAAHCVYRRNLDPTRWTAVLGLHMQSNLTSPQVVRRVVDQIVINPHYDRRRKVNDIAMMHLE----FKVNYTDYIQPICLPEENQIFIPGRTCSIAGWGYDKINAGSTVDVLKEADVPLISNEKCQQQLPEYNITESMICAGYEEGGIDSCQGDSGGPLMCQENNRWFLVGVTSFGVQCALPNHPGVYVRVSQFIEWI 1049 HSP 2 Score: 52.7582 bits (125), Expect = 8.289e-6 Identity = 36/145 (24.83%), Postives = 57/145 (39.31%), Query Frame = 1 Query: 2002 GAHYSMKSDCTAEQFKCTRGMCIELSKKCDHRDNCGDNSDEIDCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGK----NRSPN---LLVDEIKCTGTENSLEECKH 2415 G + + C ++F+C G CI L CD +C D SDE C +R G V+ W C + + + + VC LG A S+ + G N++PN +L ++C+ L +C H Sbjct: 664 GYYLGIPEPCQDDEFQCKDGNCIPLGNLCDSYPHCRDGSDEASC---------VRFLNGTRSNNGLVQFNIHSIWHIACAENWTTQISNEVCHLLGLGSANSSMPISSTGGGPFVRVNQAPNGSLILTPSLQCSQDSLILLQCNH 799
BLAST of Neurotrypsin vs. Ensembl Mouse
Match: F11 (coagulation factor XI [Source:MGI Symbol;Acc:MGI:99481]) HSP 1 Score: 172.555 bits (436), Expect = 5.449e-44 Identity = 97/242 (40.08%), Postives = 141/242 (58.26%), Query Frame = 1 Query: 3013 RVVGGFEAVYGAFPWQVGVRQKVDDYDSHWCGASILSEDWIIGAAHCYA---RPKSDYRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPNSKCLVSGWGDTL--STYPEKLLAAEVPLIKHERCFEFYK-GRLTERMQCAGYEAGGIDTCQGDSGGPLVCKVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQT 3720 RVVGG +V+G +PWQV + H CG SI+ WI+ AAHC++ PK RV G + + ++ F ++E+I+H + A YD AL+K+E + + ++ +P+CLP G +++C V+GWG T L A+VPL+ +E C Y+ ++T +M CAGY+ GG DTC+GDSGGPL CK NGV+ + G TSWG GC Q + PGVY + +DWI E+T Sbjct: 389 RVVGGAASVHGEWPWQVTLHIS----QGHLCGGSIIGNQWILTAAHCFSGIETPK-KLRVYGGIVNQSEINEGTAFFRVQEMIIHDQYTTAESGYDIALLKLES----AMNYTDFQRPICLPSKGDRNAVHTECWVTGWGYTALRGEVQSTLQKAKVPLVSNEECQTRYRRHKITNKMICAGYKEGGKDTCKGDSGGPLSCKYNGVWHLVGITSWGEGCGQKERPGVYTNVAKYVDWILEKT 621
BLAST of Neurotrypsin vs. UniProt/SwissProt
Match: sp|Q5G265|NETR_SAGLB (Neurotrypsin OS=Saguinus labiatus OX=78454 GN=PRSS12 PE=3 SV=1) HSP 1 Score: 308.531 bits (789), Expect = 1.396e-86 Identity = 201/551 (36.48%), Postives = 286/551 (51.91%), Query Frame = 1 Query: 2101 NCGDNSDE-IDCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDSH-WCGASILSEDWIIGAAHCYAR---PKSDYRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPN-SKCLVSGWGDTLSTYPEKLLAAEVPLIKHERCFEFYKGRLTERMQCAG--YEAGGIDTCQGDSGGPLVCKVNG-VYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQTGL 3726 NCG D + CT +T IRL G +EG++EV Y G+WG VCDDG+ VVC+QLGF ++ + N F ++ P + +D++ C+G E +C W H+C E G+ C GS+ V L DG + K GRVE+ G GT+CDD + DKDAAVICR L G A+A FGEG G I +DN+KCTG E +L +C G H C H ED GVIC D + + K ++ CG R + ++ R++GG ++ G +PWQV +R K D CGA++LS W++ AAHC+ R +Y VR GD+ +++E+ ++E+++H + + DYD AL++++ + +FN++V P CLP P S C ++GWGDT Y L A + L+ C E YKGR T RM CAG +E +D+CQGDSGGPL+C+ G + ++G TSWG GC +PGVY K+ + WIK T L Sbjct: 368 NCGHKEDAGVSCTPLT--DGVIRLAGGKGSHEGRLEVYYSGQWGTVCDDGWTELNTYVVCRQLGFKYGKQA---SANHFEESAGP-IWLDDVSCSGKETRFLQCSRRQWGRHDCSHREDVGIACY--------------------------------PGSEGHRLSLGFPVRLMDGENKKEGRVEVFINGQWGTICDDGWTDKDAAVICRQLGYKGPARARTMAYFGEGKGPIHVDNVKCTGNERSLADCIKQDIGRHNCRHSEDAGVIC---DYFGKKASGNSNKESLSS--VCGLRLLHRRQKRIIGGKNSLRGGWPWQVSLRLKSSHRDGRLLCGATLLSSCWVLTAAHCFKRYGNSTRNYAVRVGDYHTLVPEEFEEEIGVQEIVIHREYRPDSSDYDIALVRLQGPEEQCARFNSHVLPACLPLWRERPQKTASNCYITGWGDTGQAYSRTLQQAAIHLLPKRFCEERYKGRFTGRMLCAGNLHEHKHVDSCQGDSGGPLMCERPGESWVVYGVTSWGYGCGVKDSPGVYTKVSAFVPWIKSVTKL 875 HSP 2 Score: 142.51 bits (358), Expect = 1.350e-32 Identity = 90/262 (34.35%), Postives = 131/262 (50.00%), Query Frame = 1 Query: 2125 IDCTTVTFPPFEI-RLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVIC 2907 + C+ P F I RL G + +EG+VE+ + G+WG +CDD +D AEV+C+QL G ++ H A FG+ P +++DE++CTG E S+E+C S W HNC E AGV C +DG + LA G + GR+E+ G GTVCDD + + + V+CR L QA + F E AG I LD++ C+G+E C +WG H C+H+ED+G+ C Sbjct: 267 VMCSFSHGPAFPIIRLVGGSSVHEGRVELYHAGQWGTICDDQWDDADAEVICRQLSLSGIAKAWHQAY--FGEGSGP-VMLDEVRCTGNELSIEQCPKSSWGEHNCGHKEDAGVSC-----------------------------TPLTDGV----------IRLAGGKGSHEGRLEVYYSGQWGTVCDDGWTELNTYVVCRQLGFKYGKQASAN-HFEESAGPIWLDDVSCSGKETRFLQCSRRQWGRHDCSHREDVGIAC 485 HSP 3 Score: 128.642 bits (322), Expect = 2.629e-28 Identity = 91/275 (33.09%), Postives = 122/275 (44.36%), Query Frame = 1 Query: 2107 GDNSDEIDCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICG-LPDEVV 2928 GD ++D +RL GS N++EG VEV G WG VC +D A V+C QL G + + + G + ++C G E ++ C+ W+ C A V+C G + L G GRVEL G GT+CDD +DD DA VICR L + G A+A FGEG+G ++LD ++CTG EL++E CP WGEH C HKED GV C L D V+ Sbjct: 152 GDARGKVDWGYCDCRHGSVRLRGSKNEFEGTVEVYANGVWGTVCSSHWDDSDASVICHQLQLGGKGIAKQTPFSGLGL---IPVYWSNVRCRGDEENILLCEKDIWQGGVCPQKMAAAVMCSFS------------------------------------HGPAFPIIRLVGGSSVHEGRVELYHAGQWGTICDDQWDDADAEVICRQLSLSGIAKAWHQAYFGEGSGPVMLDEVRCTGNELSIEQCPKSSWGEHNCGHKEDAGVSCTPLTDGVI 387 HSP 4 Score: 90.8929 bits (224), Expect = 1.040e-16 Identity = 53/131 (40.46%), Postives = 73/131 (55.73%), Query Frame = 1 Query: 2086 CDHRDNCGDN---SDEIDCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVC 2469 C HR++ G E ++ FP +RL NK EG+VEV G+WG +CDDG+ K A V+C+QLG+ G + + FG+ + P + VD +KCTG E SL +C HNCR E AGV+C Sbjct: 475 CSHREDVGIACYPGSEGHRLSLGFP---VRLMDGENKKEGRVEVFINGQWGTICDDGWTDKDAAVICRQLGYKGPARA--RTMAYFGEGKGP-IHVDNVKCTGNERSLADCIKQDIGRHNCRHSEDAGVIC 599 HSP 5 Score: 67.3958 bits (163), Expect = 1.471e-9 Identity = 48/115 (41.74%), Postives = 63/115 (54.78%), Query Frame = 1 Query: 340 APESPQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPHDS--TSYCSGKS-AGVSC 675 P P IIRL G +++ +EGRVE+Y + WG +CDD W+ DA V CRQL A+ A Q +G G V + +++CTGNE S+ CP S C K AGVSC Sbjct: 274 GPAFP-IIRLVGGSSV--HEGRVELYHAGQ--WGTICDDQWDDADAEVICRQLSLSGIAK-AWHQAYFGEGSGPV---MLDEVRCTGNELSIEQCPKSSWGEHNCGHKEDAGVSC 379 HSP 6 Score: 65.0846 bits (157), Expect = 8.491e-9 Identity = 38/86 (44.19%), Postives = 50/86 (58.14%), Query Frame = 1 Query: 367 LRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDC 624 + GEN EGRVEV+ + WG +CDD W DA V CRQLG++ AR T +G G ++ V ++CTGNE+SL DC Sbjct: 503 MDGENK---KEGRVEVFINGQ--WGTICDDGWTDKDAAVICRQLGYKGPARART-MAYFGEGKGPIH---VDNVKCTGNERSLADC 579
BLAST of Neurotrypsin vs. UniProt/SwissProt
Match: sp|G3V801|NETR_RAT (Neurotrypsin OS=Rattus norvegicus OX=10116 GN=Prss12 PE=1 SV=1) HSP 1 Score: 303.908 bits (777), Expect = 4.654e-86 Identity = 211/593 (35.58%), Postives = 302/593 (50.93%), Query Frame = 1 Query: 1984 IAITYPGAHYSMKSD-CTAEQFKCTRG-MCIELSKKCDHRD-NCGDNSDE-IDCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDSH-WCGASILSEDWIIGAAHCYARPKSD---YRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPN-SKCLVSGWGDTLSTYPEKLLAAEVPLIKHERCFEFYKGRLTERMQCAG--YEAGGIDTCQGDSGGPLVC-KVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQTGL 3726 IA + AH+ S ++ +CT + IE K + NCG D + C +T IRL+G + +EG++EV Y+G+WG VCDDG+ V C+ LGF +S +VN F + P + +D++ C+G E S +C W H+C E G+ C D SDG G + L DG + + GRVE+ G GT+CDD + DK AAVICR L G A+A FGEG G I +DN+KCTG E L +C G H C H ED GVIC D + K ++G CG R + ++ R++GG ++ GA+PWQ +R K D CGA++LS W++ AAHC+ R ++ Y VR GD+ +++EQ ++++++H N+ + DYD AL++++ + + + +V P CLP P S C ++GWGDT Y L A VPL+ C E YKG T RM CAG E +D+CQGDSGGPL+C K + + ++G TSWG GC PGVY ++ + WIK T L Sbjct: 212 IAKAWHQAHFGEGSGPILLDEVRCTGNELSIEQCPKSSWGEHNCGHKEDAGVSCAPLT--DGVIRLSGGKSVHEGRLEVYYRGQWGTVCDDGWTEMNTYVACRLLGFKYGKQS---SVNHFEGSSRP-IWLDDVSCSGKEASFIQCSRRQWGRHDCSHREDVGLTCYPD-----------------------------SDGHRLSPG---FPIRLMDGENKREGRVEVFVSGQWGTICDDGWTDKHAAVICRQLGYKGPARARTMAYFGEGKGPIHMDNVKCTGNEKALADCVKQDIGRHNCRHSEDAGVIC---DYYEKKTSGHGNKETLSSG--CGLRLLHRRQKRIIGGNNSLRGAWPWQASLRLKSTHGDGRLLCGATLLSSCWVLTAAHCFKRYGNNSRSYAVRVGDYHTLVPEEFEQEIGVQQIVIHRNYRPDSSDYDIALVRLQGSGEQCARLSTHVLPACLPLWRERPQKTASNCHITGWGDTGRAYSRTLQQAAVPLLPKRFCKERYKGLFTGRMLCAGNLQEDNRVDSCQGDSGGPLMCEKPDETWVVYGVTSWGYGCGIKDTPGVYTRVPAFVPWIKSVTSL 761 HSP 2 Score: 133.65 bits (335), Expect = 5.366e-30 Identity = 86/253 (33.99%), Postives = 127/253 (50.20%), Query Frame = 1 Query: 2161 IRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPD 2919 IRL G + +EG+VE+ + G+WG +CDD +D AEV+C+QLG G ++ H A FG+ P +L+DE++CTG E S+E+C S W HNC E AGV C +DG + L+ G GR+E+ G GTVCDD + + + V CR+L Q+ + F + I LD++ C+G+E + C +WG H C+H+ED+G+ C PD Sbjct: 166 IRLVGGKSGHEGRVELYHAGQWGTICDDQWDDADAEVICRQLGLSGIAKAWHQA--HFGEGSGP-ILLDEVRCTGNELSIEQCPKSSWGEHNCGHKEDAGVSCA-----------------------------PLTDGV----------IRLSGGKSVHEGRLEVYYRGQWGTVCDDGWTEMNTYVACRLLGFKYGKQSSVN-HFEGSSRPIWLDDVSCSGKEASFIQCSRRQWGRHDCSHREDVGLTC-YPD 374 HSP 3 Score: 99.7525 bits (247), Expect = 1.942e-19 Identity = 57/115 (49.57%), Postives = 70/115 (60.87%), Query Frame = 1 Query: 2587 EGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICG-LPDEVV 2928 +G + L G GRVEL G GT+CDD +DD DA VICR L + G A+A FGEG+G I+LD ++CTG EL++E CP WGEH C HKED GV C L D V+ Sbjct: 159 QGPALPVIRLVGGKSGHEGRVELYHAGQWGTICDDQWDDADAEVICRQLGLSGIAKAWHQAHFGEGSGPILLDEVRCTGNELSIEQCPKSSWGEHNCGHKEDAGVSCAPLTDGVI 273 HSP 4 Score: 69.707 bits (169), Expect = 2.987e-10 Identity = 47/116 (40.52%), Postives = 62/116 (53.45%), Query Frame = 1 Query: 340 APESPQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPHDS--TSYCSGKS-AGVSCV 678 P P +IRL G + +EGRVE+Y + WG +CDD W+ DA V CRQLG A+ A Q +G G + + +++CTGNE S+ CP S C K AGVSC Sbjct: 160 GPALP-VIRLVGGK--SGHEGRVELYHAGQ--WGTICDDQWDDADAEVICRQLGLSGIAK-AWHQAHFGEGSGPI---LLDEVRCTGNELSIEQCPKSSWGEHNCGHKEDAGVSCA 266 HSP 5 Score: 64.3142 bits (155), Expect = 1.319e-8 Identity = 44/99 (44.44%), Postives = 55/99 (55.56%), Query Frame = 1 Query: 334 DGAPESPQI-IRLR-GENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDC 624 DG SP IRL GEN EGRVEV+ S WG +CDD W A V CRQLG++ AR T +G G ++ + ++CTGNEK+L DC Sbjct: 376 DGHRLSPGFPIRLMDGENK---REGRVEVFVSGQ--WGTICDDGWTDKHAAVICRQLGYKGPARART-MAYFGEGKGPIH---MDNVKCTGNEKALADC 465
BLAST of Neurotrypsin vs. UniProt/SwissProt
Match: sp|Q5G267|NETR_MACMU (Neurotrypsin OS=Macaca mulatta OX=9544 GN=PRSS12 PE=3 SV=1) HSP 1 Score: 306.605 bits (784), Expect = 5.192e-86 Identity = 200/551 (36.30%), Postives = 288/551 (52.27%), Query Frame = 1 Query: 2101 NCGDNSDE-IDCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDSH-WCGASILSEDWIIGAAHCYAR---PKSDYRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPN-SKCLVSGWGDTLSTYPEKLLAAEVPLIKHERCFEFYKGRLTERMQCAG--YEAGGIDTCQGDSGGPLVCKVNG-VYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQTGL 3726 NCG D + CT +T IRL G +EG++EV Y+G+WG VCDDG+ VVC+QLGF ++ + N F ++ P + +D++ C+G E +C W H+C E D + C GS+ V L DG + K GRVE+ G GT+CDD + DKDAAVICR L G A+A FGEG G I +DN+KCTG E +L +C G H C H ED GVIC D + + K ++ CG R + ++ R++GG ++ G +PWQV +R K D CGA++LS W++ AAHC+ R +Y VR GD+ +++E+ ++++++H + + DYD AL++++ + +F+++V P CLP P S C ++GWGDT Y L A +PL+ C E YKGR T RM CAG +E +D+CQGDSGGPL+C+ G + ++G TSWG GC +PGVY K+ + WIK T L Sbjct: 368 NCGHKEDAGVSCTPLT--DGVIRLAGGKGSHEGRLEVYYRGQWGTVCDDGWTELNTYVVCRQLGFKYGKQA---SANHFEESTGP-IWLDDVSCSGKETRFLQCSRRQWGQHDCSHHE--------------------------------DVSIACYPGSEGHRLSLGFPVRLMDGENKKEGRVEVFINGQWGTICDDGWTDKDAAVICRQLGYKGPARARTMAYFGEGKGPIHVDNVKCTGNERSLADCIKQDIGRHNCRHSEDAGVIC---DYFGKKASGNSNKESLSS--VCGLRLLHRRQKRIIGGKNSLRGGWPWQVSLRLKSSHGDGRLLCGATLLSSCWVLTAAHCFKRYGNSTRNYAVRVGDYHTLVPEEFEEEIGVQQIVIHREYRPDSSDYDIALVRLQGPEEQCARFSSHVLPACLPFWRERPQKTASNCYITGWGDTGRAYSRTLQQAAIPLLPKRFCEERYKGRFTGRMLCAGNLHEHKRVDSCQGDSGGPLMCERPGESWAVYGVTSWGYGCGVKDSPGVYTKVSAFVPWIKSVTKL 875 HSP 2 Score: 140.584 bits (353), Expect = 5.500e-32 Identity = 89/262 (33.97%), Postives = 130/262 (49.62%), Query Frame = 1 Query: 2125 IDCTTVTFPPFEI-RLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVIC 2907 + C+ P F I RL G + +EG+VE+ + G+WG +CDD +D AEV+C+QLG G ++ H A FG+ P +++DE++CTG E S+E+C S W HNC E AGV C +DG + LA G + GR+E+ G GTVCDD + + + V+CR L QA + F E G I LD++ C+G+E C +WG+H C+H ED+ + C Sbjct: 267 VTCSFSRGPAFPIIRLVGGSSVHEGRVELYHAGQWGTICDDQWDDADAEVICRQLGLSGIAKAWHQAY--FGEGSGP-VMLDEVRCTGNELSIEQCPKSSWGEHNCGHKEDAGVSC-----------------------------TPLTDGV----------IRLAGGKGSHEGRLEVYYRGQWGTVCDDGWTELNTYVVCRQLGFKYGKQASAN-HFEESTGPIWLDDVSCSGKETRFLQCSRRQWGQHDCSHHEDVSIAC 485 HSP 3 Score: 129.028 bits (323), Expect = 1.947e-28 Identity = 91/275 (33.09%), Postives = 121/275 (44.00%), Query Frame = 1 Query: 2107 GDNSDEIDCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICG-LPDEVV 2928 GD ++D +RL G N++EG VEV G WG VC +D A V+C QL G + + + G + ++C G E ++ C+ W+ C A V C R G + L G GRVEL G GT+CDD +DD DA VICR L + G A+A FGEG+G ++LD ++CTG EL++E CP WGEH C HKED GV C L D V+ Sbjct: 152 GDARGKVDWGYCDCRHGSVRLRGGKNEFEGTVEVYASGAWGTVCSSHWDDSDASVICHQLQLGGKGIAKQTPFSGLGL---IPIYWSNVRCRGDEENILLCEKDIWQGGVCPQKMAAAVTCSFSR------------------------------------GPAFPIIRLVGGSSVHEGRVELYHAGQWGTICDDQWDDADAEVICRQLGLSGIAKAWHQAYFGEGSGPVMLDEVRCTGNELSIEQCPKSSWGEHNCGHKEDAGVSCTPLTDGVI 387 HSP 4 Score: 70.0922 bits (170), Expect = 2.300e-10 Identity = 49/115 (42.61%), Postives = 64/115 (55.65%), Query Frame = 1 Query: 340 APESPQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPHDS--TSYCSGKS-AGVSC 675 P P IIRL G +++ +EGRVE+Y + WG +CDD W+ DA V CRQLG A+ A Q +G G V + +++CTGNE S+ CP S C K AGVSC Sbjct: 274 GPAFP-IIRLVGGSSV--HEGRVELYHAGQ--WGTICDDQWDDADAEVICRQLGLSGIAK-AWHQAYFGEGSGPV---MLDEVRCTGNELSIEQCPKSSWGEHNCGHKEDAGVSC 379 HSP 5 Score: 64.6994 bits (156), Expect = 9.560e-9 Identity = 38/86 (44.19%), Postives = 50/86 (58.14%), Query Frame = 1 Query: 367 LRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDC 624 + GEN EGRVEV+ + WG +CDD W DA V CRQLG++ AR T +G G ++ V ++CTGNE+SL DC Sbjct: 503 MDGENK---KEGRVEVFINGQ--WGTICDDGWTDKDAAVICRQLGYKGPARART-MAYFGEGKGPIH---VDNVKCTGNERSLADC 579
BLAST of Neurotrypsin vs. UniProt/SwissProt
Match: sp|O08762|NETR_MOUSE (Neurotrypsin OS=Mus musculus OX=10090 GN=Prss12 PE=1 SV=1) HSP 1 Score: 302.753 bits (774), Expect = 1.054e-85 Identity = 211/593 (35.58%), Postives = 300/593 (50.59%), Query Frame = 1 Query: 1984 IAITYPGAHYSMKSD-CTAEQFKCTRG-MCIELSKKCDHRD-NCGDNSDE-IDCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDSH-WCGASILSEDWIIGAAHCYARPKSD---YRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPN-SKCLVSGWGDTLSTYPEKLLAAEVPLIKHERCFEFYKGRLTERMQCAG--YEAGGIDTCQGDSGGPLVC-KVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQTGL 3726 IA + AH+ S ++ +CT + IE K + NCG D + C +T IRL G + +EG++EV Y+G+WG VCDDG+ V C+ LGF +S +VN F + P + +D++ C+G E S +C W H+C E G+ C D SDG G + L DG + K GRVE+ G GT+CDD + DK AAVICR L G A+A FGEG G I +DN+KCTG E L +C G H C H ED GVIC D + + K ++G CG R + ++ R++GG ++ GA+PWQ +R + D CGA++LS W++ AAHC+ R ++ Y VR GD+ +++EQ ++++++H N+ DYD AL++++ + + +V P CLP P S C ++GWGDT Y L A VPL+ C E YKG T RM CAG E +D+CQGDSGGPL+C K + + ++G TSWG GC PGVY ++ + WIK T L Sbjct: 212 IAKAWHQAHFGEGSGPILLDEVRCTGNELSIEQCPKSSWGEHNCGHKEDAGVSCVPLT--DGVIRLAGGKSTHEGRLEVYYKGQWGTVCDDGWTEMNTYVACRLLGFKYGKQS---SVNHFDGSNRP-IWLDDVSCSGKEVSFIQCSRRQWGRHDCSHREDVGLTCYPD-----------------------------SDGHRLSPG---FPIRLVDGENKKEGRVEVFVNGQWGTICDDGWTDKHAAVICRQLGYKGPARARTMAYFGEGKGPIHMDNVKCTGNEKALADCVKQDIGRHNCRHSEDAGVIC---DYLEKKASSSGNKEMLSSG--CGLRLLHRRQKRIIGGNNSLRGAWPWQASLRLRSAHGDGRLLCGATLLSSCWVLTAAHCFKRYGNNSRSYAVRVGDYHTLVPEEFEQEIGVQQIVIHRNYRPDRSDYDIALVRLQGPGEQCARLSTHVLPACLPLWRERPQKTASNCHITGWGDTGRAYSRTLQQAAVPLLPKRFCKERYKGLFTGRMLCAGNLQEDNRVDSCQGDSGGPLMCEKPDESWVVYGVTSWGYGCGVKDTPGVYTRVPAFVPWIKSVTSL 761 HSP 2 Score: 132.88 bits (333), Expect = 8.657e-30 Identity = 87/254 (34.25%), Postives = 129/254 (50.79%), Query Frame = 1 Query: 2161 IRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDE 2922 IRL G + +EG+VE+ + G+WG +CDD +D A+V+C+QLG G ++ H A FG+ P +L+DE++CTG E S+E+C S W HNC E AGV C+ L +DG + LA G GR+E+ G GTVCDD + + + V CR+L Q+ + F I LD++ C+G+E++ C +WG H C+H+ED+G+ C PD Sbjct: 166 IRLVGGNSGHEGRVELYHAGQWGTICDDQWDNADADVICRQLGLSGIAKAWHQA--HFGEGSGP-ILLDEVRCTGNELSIEQCPKSSWGEHNCGHKEDAGV-------------------SCVPL----------TDGV----------IRLAGGKSTHEGRLEVYYKGQWGTVCDDGWTEMNTYVACRLLGFKYGKQSSVN-HFDGSNRPIWLDDVSCSGKEVSFIQCSRRQWGRHDCSHREDVGLTC-YPDS 375 HSP 3 Score: 98.2117 bits (243), Expect = 5.754e-19 Identity = 53/107 (49.53%), Postives = 66/107 (61.68%), Query Frame = 1 Query: 2587 EGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVIC 2907 +G + L G GRVEL G GT+CDD +D+ DA VICR L + G A+A FGEG+G I+LD ++CTG EL++E CP WGEH C HKED GV C Sbjct: 159 QGPALPVIRLVGGNSGHEGRVELYHAGQWGTICDDQWDNADADVICRQLGLSGIAKAWHQAHFGEGSGPILLDEVRCTGNELSIEQCPKSSWGEHNCGHKEDAGVSC 265 HSP 4 Score: 73.559 bits (179), Expect = 2.106e-11 Identity = 49/116 (42.24%), Postives = 65/116 (56.03%), Query Frame = 1 Query: 340 APESPQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPHDS--TSYCSGKS-AGVSCV 678 P P +IRL G N + +EGRVE+Y + WG +CDD W+ DA+V CRQLG A+ A Q +G G + + +++CTGNE S+ CP S C K AGVSCV Sbjct: 160 GPALP-VIRLVGGN--SGHEGRVELYHAGQ--WGTICDDQWDNADADVICRQLGLSGIAK-AWHQAHFGEGSGPI---LLDEVRCTGNELSIEQCPKSSWGEHNCGHKEDAGVSCV 266 HSP 5 Score: 62.3882 bits (150), Expect = 5.309e-8 Identity = 43/99 (43.43%), Postives = 55/99 (55.56%), Query Frame = 1 Query: 334 DGAPESPQI-IRL-RGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDC 624 DG SP IRL GEN EGRVEV+ + WG +CDD W A V CRQLG++ AR T +G G ++ + ++CTGNEK+L DC Sbjct: 376 DGHRLSPGFPIRLVDGENK---KEGRVEVFVNGQ--WGTICDDGWTDKHAAVICRQLGYKGPARART-MAYFGEGKGPIH---MDNVKCTGNEKALADC 465
BLAST of Neurotrypsin vs. UniProt/SwissProt
Match: sp|Q5G268|NETR_NOMLE (Neurotrypsin OS=Nomascus leucogenys OX=61853 GN=PRSS12 PE=3 SV=1) HSP 1 Score: 305.064 bits (780), Expect = 1.647e-85 Identity = 199/551 (36.12%), Postives = 288/551 (52.27%), Query Frame = 1 Query: 2101 NCGDNSDE-IDCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDSH-WCGASILSEDWIIGAAHCYAR---PKSDYRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPN-SKCLVSGWGDTLSTYPEKLLAAEVPLIKHERCFEFYKGRLTERMQCAG--YEAGGIDTCQGDSGGPLVCKVNG-VYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQTGL 3726 NCG D + CT +T IRL G +EG++EV Y+G+WG VCDDG+ VVC+QLGF ++ + N F ++ P + +D++ C+G E +C W H+C E D + C G + V L DG + K GRVE+ G GT+CDD + DKDAAVICR L G A+A FGEG G I +DN+KCTG E +L +C G H C H ED GVIC D + + K ++ CG R + ++ R++GG ++ G +PWQV +R K D CGA++LS W++ AAHC+ R +Y VR GD+ +++E+ ++++++H + + DYD AL++++ + +F+++V P CLP P S C ++GWGDT Y L A +PL+ C E YKGR T RM CAG +E +D+CQGDSGGPL+C+ G + ++G TSWG+GC +PGVY K+ + WIK T L Sbjct: 368 NCGHKEDAGVSCTPLT--DGVIRLAGGKGSHEGRLEVYYRGQWGTVCDDGWTELNTYVVCRQLGFKYGKQA---SANHFEESTGP-IWLDDVSCSGKETRFLQCSRRQWGRHDCSHRE--------------------------------DVSIACYPGGEGHRLSLGFPVRLMDGENKKEGRVEVFINGQWGTICDDGWTDKDAAVICRQLGYKGPARARTMAYFGEGKGPIHVDNVKCTGNERSLADCIKQDIGRHNCRHSEDAGVIC---DYFGKKASGNSNKESLSS--VCGLRLLHRRQKRIIGGKNSLRGGWPWQVSLRLKSSHGDGRLLCGATLLSSCWVLTAAHCFKRYGNSTRNYAVRVGDYHTLVPEEFEEEIGVQQIVIHREYRPDSSDYDIALVRLQGPEEQCARFSSHVLPACLPLWRERPQKTASNCYITGWGDTGRAYSRTLQQAAIPLLPKRFCEERYKGRFTGRMLCAGNLHEHKRVDSCQGDSGGPLMCERPGESWVVYGVTSWGHGCGVKDSPGVYTKVSAFVPWIKSVTKL 875 HSP 2 Score: 140.969 bits (354), Expect = 4.175e-32 Identity = 90/262 (34.35%), Postives = 130/262 (49.62%), Query Frame = 1 Query: 2125 IDCTTVTFPPFEI-RLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVIC 2907 + C+ P F I RL G + +EG+VE+ + G+WG VCDD +D AEV+C+QLG G ++ H A FG+ P +++DE++CTG E S+E+C S W HNC E AGV C +DG + LA G + GR+E+ G GTVCDD + + + V+CR L QA + F E G I LD++ C+G+E C +WG H C+H+ED+ + C Sbjct: 267 VTCSFSHGPTFPIIRLVGGSSVHEGRVELYHAGQWGTVCDDQWDDADAEVICRQLGLSGIAKAWHQAY--FGEGSGP-VMLDEVRCTGNELSIEQCPKSSWGEHNCGHKEDAGVSC-----------------------------TPLTDGV----------IRLAGGKGSHEGRLEVYYRGQWGTVCDDGWTELNTYVVCRQLGFKYGKQASAN-HFEESTGPIWLDDVSCSGKETRFLQCSRRQWGRHDCSHREDVSIAC 485 HSP 3 Score: 127.872 bits (320), Expect = 4.999e-28 Identity = 93/275 (33.82%), Postives = 120/275 (43.64%), Query Frame = 1 Query: 2107 GDNSDEIDCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICG-LPDEVV 2928 GD ++D IRL G N++EG VEV G WG VC +D A V+C QL G + + + G + ++C G E ++ C+ W+ C A V C T R L G GRVEL G GTVCDD +DD DA VICR L + G A+A FGEG+G ++LD ++CTG EL++E CP WGEH C HKED GV C L D V+ Sbjct: 152 GDARGKVDWGYCDCRHGSIRLRGGKNEFEGTVEVYASGVWGTVCSSHWDDSDASVICHQLQLGGKGIAKQTPFSGLGL---IPIYWSNVRCRGDEENILLCEKDIWQGGVCPQKMAAAVTCSFSHGPTFPIIR------------------------------------LVGGSSVHEGRVELYHAGQWGTVCDDQWDDADAEVICRQLGLSGIAKAWHQAYFGEGSGPVMLDEVRCTGNELSIEQCPKSSWGEHNCGHKEDAGVSCTPLTDGVI 387 HSP 4 Score: 70.4774 bits (171), Expect = 2.008e-10 Identity = 48/109 (44.04%), Postives = 62/109 (56.88%), Query Frame = 1 Query: 358 IIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPHDS--TSYCSGKS-AGVSC 675 IIRL G +++ +EGRVE+Y + WG VCDD W+ DA V CRQLG A+ A Q +G G V + +++CTGNE S+ CP S C K AGVSC Sbjct: 279 IIRLVGGSSV--HEGRVELYHAGQ--WGTVCDDQWDDADAEVICRQLGLSGIAK-AWHQAYFGEGSGPV---MLDEVRCTGNELSIEQCPKSSWGEHNCGHKEDAGVSC 379 HSP 5 Score: 65.0846 bits (157), Expect = 8.636e-9 Identity = 38/86 (44.19%), Postives = 50/86 (58.14%), Query Frame = 1 Query: 367 LRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDC 624 + GEN EGRVEV+ + WG +CDD W DA V CRQLG++ AR T +G G ++ V ++CTGNE+SL DC Sbjct: 503 MDGENK---KEGRVEVFINGQ--WGTICDDGWTDKDAAVICRQLGYKGPARART-MAYFGEGKGPIH---VDNVKCTGNERSLADC 579
BLAST of Neurotrypsin vs. TrEMBL
Match: A0A267GUN8 (Uncharacterized protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig012109g1 PE=3 SV=1) HSP 1 Score: 778.474 bits (2009), Expect = 0.000e+0 Identity = 471/1239 (38.01%), Postives = 672/1239 (54.24%), Query Frame = 1 Query: 217 TRHKRQAVSE--DETTFFDQNIPPLTGTGRSNTRFP----MRKVRDGAPESPQIIRLRGE-NALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCT--GNEKSLVDCPHDSTSYCS-GKSAGVSCVYNLGCPNGWISFNGACYQINTQQMDYKQADKFCQDHNSKLAFILKAKENNFISNVLYTQYKSIAQIWTGGYYAEVKLDEGRSEFRWNWYSTIHNVDQWSTSNLWFPGFYETKTDKRPQGDPKTQSCVALNRAFADSQRQNTVYDVNYFWWDNLSCNEKLPFICQMNIPQSRSDCYEDNGLDYRGRISRTVQGSSCAKWTDPAATVNPQTNPEAGLGDHNFCRNPDNDLQPWCWTNPTNGVYGYCAIGKCS-ELPPPTATLKPQVTDPM--GFGQGGCQSIQ-YHCPSMISYNRQCIPKNEVCDKIPHCLGKEDEDHGFCKKYLCKENEFFCASDMFCILKTHVCDGKRNCADGSDEKNCTVLDESALLKVYDKTDSKI---LDVSDKLDYIDIPID------------KCAEKCKILFHQFACKSFNYLPPHESRTHSECRLLTKLASEEPYKLIAITYPGAHYSMKSDCT-AEQFKCTRGMCIELSKKCDHRDNCGDNSDEID--CTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPW-RSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIV-LDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVD-----------DYDSHWCGASILSEDWIIGAAHCYA---RPKSDYRVRTGDWDNASDDKYEQVFEIEELILHPNWXX-XXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLG--MVPDPNSKCLVSGWGDTLS-TYPEKLLAAEVPLIKHERCFEFYK-GRLTERMQCAGYEAGGIDTCQGDSGGPLVCKV----------------------NGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWI 3708 R +R+A S F D N P G R++ R G P +PQI+R+RG+ + NEGRVEV + +WGLVC DY ++A + C QLGF A + YG G + D V +QC G+E +L DC C + G+ C+YN GC GW SF+G CY++ T+ +A CQ +KL + +E N+I+N+LYT+++S+ +WTGG + + D G W + TIH Q LWFPGF E TD+RP GDP+ +SC+A+++ F + + + V DVNYFWWDN+SC +LPF+CQ + + +DCYE G DYRG +RT +G+ C W D +NP T P AGL H CRNPD D +PWCW + N V+GYC++ +CS ELP +PQ PM GFG C + + CPSM+SY C+ + +VCD C+GKEDED FC+ Y C + F+C CI VCDG +C G DE E A + V + ++++ ++ +D +P D +CA+ C L QF CKSF Y E R S+C LL + +P + +Y + C A+ F C C++ S+ C+ D+CGD SDEI+ C +E+ L+G + +EG++E+R + G VCDDG + A+V+C+QLG+ G I +A +FG+ + ++ + C ++ +C H PW S C +AG++C +DR C+ E RC D C LSK+CD DCSDG DE E + VTL+ + +G VE+SRGG++G VCDD + D++ V+CR L IPGR + +F AG ++ L +++C G E +L +C WGE C+ E + ++CGLP+ VT P A + + CG R + R+ GG + PWQV +R+KV S WCG +ILS+ WI+ AAHC+ PKS + VR GDW+N + D+YE+ F+++ LI H + YD+D +L++I+ + ++FN VQP CLP+ M DP SKCL+SGWG YPE L AEVPLI+ E C Y+ +TERM CAGY+ GGID CQGDSGGPLVCK+ +T+ G TS+GNGCA+P +PGVY + +WI Sbjct: 63 ARSRREATSPFIPLRLFGDSNPEPQPGYPRTSPDSKPDELSRHRTGGVPPTPQIVRIRGDLMKMNPNEGRVEV--NYHGVWGLVCGDYVQQIEATLVCHQLGFELGANRVYKNSYYGTGHYKRQDIIVGHVQCKHDGDELTLFDCNRKLMPPCDLNSTTGIECIYNTGCDWGWSSFDGLCYRLETEPKTATEAATACQAKGAKLVSVNSLEEGNYITNMLYTKFRSLNAVWTGGQFGSFR-DVGSQYTSWTFVDTIHMARQ----PLWFPGF-EPGTDQRPAGDPQQRSCIAMSKLFQNPRSRRDV-DVNYFWWDNISCKTRLPFVCQ-KLAVASADCYEGIGTDYRGLAARTDKGTPCQPWGD-NQLINPSTYPNAGLSGHGLCRNPDGDAKPWCWVDNKNNVFGYCSLRQCSDELP------QPQEGPPMTPGFGHEKCDRHEDFFCPSMLSYRPVCVVERQVCDGFVDCVGKEDEDEAFCRNYTCTSDHFYCRKFHKCISMDQVCDGLADCDLGDDET------EEACMSVKAQAEAELANEFQMTAGIDESSVPADAKLAIYYRKTLVQCAKHCDRL-EQFFCKSFIYYRTGEQRFQSKCFLLGSRIT-DPASKADPSIEAKYYEIPETCNDADDFLCNNSHCVKKSQACNGFDDCGDFSDEINSRCGKDPAKNYELVLSGGSDNHEGRIEIRLFNQRGLVCDDGLNAAMADVICQQLGYPGHERFILNAWQQFGRG-TGGFILSGVHCGPGAKNITDCAHRPWGDSGACSVKNVAGLICLIDRPCSMHEVRC--DSRCFPLSKMCDGVPDCSDGWDETECD-ILNVTLSH--NRTAGVVEISRGGIQGVVCDDHFSDEEVKVVCRHLGIPGRGALAQRGQFSTPAGVVMWLQDIRCEGTEASLFDCSLRDWGESTCSIDEAVQLLCGLPE--VTDPETTQAPQTDYSEI-CGKRLAPYSFYRIGGGRNSGITEVPWQVAIRKKVIRPAGLRKDIKLPSSSAWCGGTILSDRWILSAAHCFPYANMPKSAFVVRAGDWNNTAPDQYEREFDVDLLIQHERYTGPPAYDFDISLLRIKPDSRGYLEFNAGVQPACLPRQNQPMNYDPTSKCLISGWGSRGGFDYPEALQMAEVPLIRREVCDRMYEFENITERMFCAGYKEGGIDACQGDSGGPLVCKIVDPGPPAEAGGAAAKGGPLRSGEARHTVVGITSFGNGCAEPNSPGVYTHVPYFRNWI 1267
BLAST of Neurotrypsin vs. TrEMBL
Match: A0A267FDY5 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig019787g1 PE=3 SV=1) HSP 1 Score: 774.237 bits (1998), Expect = 0.000e+0 Identity = 465/1162 (40.02%), Postives = 663/1162 (57.06%), Query Frame = 1 Query: 337 GAPESPQIIRLRGE-NALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTG--NEKSLVDCPHDSTSYCS-GKSAGVSCVYNLGCPNGWISFNGACYQINTQQMDYKQADKFCQDHNSKLAFILKAKENNFISNVLYTQYKSIAQIWTGGYYAEVKLDEGRSEFRWNWYSTIHNVDQWSTSNLWFPGFYETKTDKRPQGDPKTQSCVALNRAFADSQRQNTVYDVNYFWWDNLSCNEKLPFICQMNIPQSRSDCYEDNGLDYRGRISRTVQGSSCAKWTDPAATVNPQTNPEAGLGDHNFCRNPDNDLQPWCWTNPTNGVYGYCAIGKCSE------LPPPTATLKPQVTDPMGFGQGGCQSI-QYHCPSMISYNRQCIPKNEVCDKIPHCLGKEDEDHGFCKKYLCKENEFFCASDMFCILKTHVCDGKRNCADGSDE--KNCTVL-----DESALLKVYDKTD----SKILDVSDKLDYIDIPIDKCAEKCKILFHQFACKSFNYLPPHESRTHSECRLLT-KLASEEPYKLIAITYPGAHYSMKSDCTAEQ-FKCTRGMCIELSKKCDHRDNCGDNSDEIDCTTVT--FPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRS-HNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPE-GKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIV-LDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPT----AKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDS-HWCGASILSEDWIIGAAHCYARPKSDYRVRTGDWDNASDDKYEQVFEIEELILHPNWXXX-XXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPNSKCLVSGWGDTLST-YPEKLLAAEVPLIKHERCFEFYKGRLTERMQCAGYEAGGIDTCQGDSGGPLVCKVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKE 3714 G P SPQ RLRGE + + NEGRVEV + WGL C DY+ +ANV CR LGF++ A + + +G G++ D + ++C + +L C H+ CS +AGV C YN GC GW +++G CY++ + M + A K C+ +KL + EN+FI+N+LYT+++ IA WTGG YA + D+ + W + TIH V S S LWFPGF T++D RP G+ + QSC+A+++ F S + V D NYFWWDN+SC +LP+ICQ + SDCY +G +YRG +RT +G+ C W++ VN T+P GLG+HN CRNPD D +PWCW + V+GYC++ C E LP LKP + C S QY CPSMI+Y C+ + +VCD C+G EDE+ CK C +F+C CI + VCD + +C G DE + C + ++ + K Y KT+ S I + + Y + + +C +C + +F C +F Y H + C LL K+A P + + +Y K C +Q F+C C++ + C+ D+CGD SDE+ ++ P F +RL+G YEG+VEV+ EWG +CDDG + +VVC QLGF E + + L+ + C GTE SL +C HS W++ NC + +AG+VC DRACT+ EFRCS CI LS+VCD T C+DG+DE G T+ + DGP SG +E++R G+ G VCDD + D +A V+C L IPGR + + F G ++ L ++KC+G E +L +C WG C +E + + CGLP+ T PT A+V +A CG R GR++ G+ A+ G FPWQVG+R KV + D+ CG +I+++ WI+ AAHC+ PKS Y +R GD DN +++E+ F+I+ + +HP ++ +YDYD LI+I+ + I+FN VQP CLP+ + + C +SGWG P L+AA VPLI + RC + Y GR+T+RMQCAG+EAGGID+CQGDSGGPLVC ++GVYT+ GATSWG GCA P +PGVYA I+ DWI E Sbjct: 96 GVPVSPQKARLRGELSHMNPNEGRVEVEYRGT--WGLACGDYFGREEANVYCRNLGFKKGANKPYGRSFFGTGNFKRWDILIGHVKCAAYRGQSNLFQCSHNLMPACSLNNTAGVECTYNEGCEFGWSAYDGLCYRVESGPMTAEDAAKACKAKGAKLVAVNSQGENSFITNMLYTKFQDIAAAWTGGQYARFR-DQLEYD-AWTFKDTIHLVK--SDSKLWFPGF--TESDARPIGNKEKQSCIAISKIFYKSSERRDV-DTNYFWWDNISCKTELPYICQ-KLGTLTSDCYSQSGGNYRGEAARTDKGTPCQPWSE-NRLVNSMTHPGQGLGEHNLCRNPDGDTKPWCWVDNERNVFGYCSLRLCGEGEGGDGLP---TDLKPS------YNHSRCDSPDQYFCPSMINYRPTCVDRRQVCDSHKDCVGGEDEERELCKA-RCNSEQFYCRKSHRCIAISKVCDKQYDCDMGDDETPEACRLHKPEEESDAEVQKDYTKTEKVDESSIPSGTQSVSYYSLSLTQCKTRCDTM-DRFVCAAFIY--NHNATFGIRCTLLAQKIADVRPNDAVGES---VYYEKKQSCNPDQKFQCKNTRCVDKAALCNGYDDCGDFSDEVGPSSCPDPKPTFSVRLSGGRGNYEGRVEVKLFNEWGLMCDDGLNENLGKVVCNQLGFPMGYEKLSKNAKKEYGRGDGKFLMGAVACRGTEASLYDCPHSGWKNIVNCTINNVAGIVCLWDRACTDKEFRCSG--RCIPLSQVCDGTQQCTDGADEESCGTPTLALRNGDGP--SSGFLEITRNGIAGAVCDDMFGDNEAKVVCAQLGIPGRFRLEPEGTFKTPGGTVMWLQDVKCSGSESSLFSCAIRNWGRSLCEIREAVNLRCGLPEPTRTTTQPPTTTTPARVTSSAK-TCGQRIGRFPAGRIINGYPAIRGQFPWQVGIRLKVSETDTRQHCGGTIINDRWIVTAAHCFDYPKSYYAIRVGDLDNMVTEEFERQFDIDLVFIHPQYSGQPSYDYDITLIRIQPDSKGYIEFNAAVQPACLPEKTLQTTRKTVCHISGWGSVGDMQLPRNLMAANVPLIANARCNQLYPGRITDRMQCAGFEAGGIDSCQGDSGGPLVCPIDGVYTLLGATSWGEGCAMPGSPGVYANIRNLRDWIDE 1225
BLAST of Neurotrypsin vs. TrEMBL
Match: A0A267FXX8 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig004114g1 PE=3 SV=1) HSP 1 Score: 773.081 bits (1995), Expect = 0.000e+0 Identity = 466/1164 (40.03%), Postives = 668/1164 (57.39%), Query Frame = 1 Query: 337 GAPESPQIIRLRGE-NALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTG--NEKSLVDCPHDSTSYCS-GKSAGVSCVYNLGCPNGWISFNGACYQINTQQMDYKQADKFCQDHNSKLAFILKAKENNFISNVLYTQYKSIAQIWTGGYYAEVKLDEGRSEF-RWNWYSTIHNVDQWSTSNLWFPGFYETKTDKRPQGDPKTQSCVALNRAFADSQRQNTVYDVNYFWWDNLSCNEKLPFICQMNIPQSRSDCYEDNGLDYRGRISRTVQGSSCAKWTDPAATVNPQTNPEAGLGDHNFCRNPDNDLQPWCWTNPTNGVYGYCAIGKCSE------LPPPTATLKPQVTDPMGFGQGGCQSI-QYHCPSMISYNRQCIPKNEVCDKIPHCLGKEDEDHGFCKKYLCKENEFFCASDMFCILKTHVCDGKRNCADGSDE--KNCTVL-----DESALLKVYDKTD----SKILDVSDKLDYIDIPIDKCAEKCKILFHQFACKSFNYLPPHESRTHSECRLLT-KLASEEPYKLIAITYPGAHYSMKSDCTAEQ-FKCTRGMCIELSKKCDHRDNCGDNSDEIDCTTVT--FPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGF-LGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRS-HNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPE-GKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIV-LDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPT----AKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDS-HWCGASILSEDWIIGAAHCYARPKSDYRVRTGDWDNASDDKYEQVFEIEELILHPNWXXX-XXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPNSKCLVSGWGDTLST-YPEKLLAAEVPLIKHERCFEFYKGRLTERMQCAGYEAGGIDTCQGDSGGPLVCKVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKE 3714 G P SPQ RLRGE + + NEGRVEV + WGL C DY+ +ANV CR LGF++ A + + +G G++ D + ++C + +L C H+ CS +AGV C YN GC GW +++G CY++ + M + A K C+ +KL + EN+FI+N+LYT+++ IA WTGG YA + + E+ W + TIH V S S LWFPGF T++D RP G+ + QSC+A+++ F S + V D NYFWWDN+SC +LP+ICQ + SDCY +G +YRG +RT +G+ C W++ VN T+P GLG+HN CRNPD D +PWCW + V+GYC++ C E LP LKP + C S QY CPSMI+Y C+ + +VCD C+G EDE+ CK C +F+C CI + VCD + +C G DE + C + ++ + K Y KT+ S I + + Y + + +C +C + +F C +F Y H + C LL K+A P + + +Y K C +Q F+C C++ + C+ D+CGD SDE+ ++ P F +RL+G YEG+VEV+ EWG +CDDG + +VVC QLGF +G + +A +G+ L+ + C GTE SL +C HS W++ NC + +AG+VC DRACT+ EFRCS CI L++VCD T C+DG+DE G T+ + DGP SG +E++R G+ G VCDD + D +A V+C L IPGR + + F G ++ L ++KC+G E +L +C WG C +E + + CGLP+ T PT A+V +A CG R GR++ G+ A+ G FPWQVG+R KV + D+ CG +I+++ WI+ AAHC+ PKS Y +R GD DN +++E+ F+I+ + +HP ++ +YDYD LI+I+ + I+FN VQP CLP+ + + C +SGWG P L+AA VPLI + RC + Y GR+T+RMQCAG+EAGGID+CQGDSGGPLVC ++GVYT+ GATSWG GCA P +PGVYA I+ DWI E Sbjct: 96 GVPVSPQKARLRGELSHMNPNEGRVEVEYRGT--WGLACGDYFGREEANVYCRNLGFKKGANKPYGRSFFGTGNFKRWDILIGHVKCAAYRGQSNLFQCSHNLMPACSLNNTAGVECTYNEGCEFGWSAYDGLCYRVESGPMTAEDAAKACKAKGAKLVAVNSQGENSFITNMLYTKFQDIAAAWTGGQYARFR---DQLEYDAWTFKDTIHLVK--SDSKLWFPGF--TESDARPIGNKEKQSCIAISKIFYKSSERRDV-DTNYFWWDNISCKTELPYICQ-KLGTLTSDCYSQSGGNYRGEAARTDKGTPCQPWSE-NRLVNSMTHPGQGLGEHNLCRNPDGDTKPWCWVDNERNVFGYCSLRLCGEGEGGDGLP---TDLKPS------YNHSRCDSPDQYFCPSMINYRPTCVDRRQVCDSHKDCVGGEDEERELCKA-RCNSEQFYCRKSHRCIAISKVCDKQYDCDMGDDETPEACRLHKPEEESDAEVQKDYTKTEKVDESSIPSGTQSVSYYSLSLTQCKTRCDTM-DRFVCAAFIY--NHNATFGIRCTLLAQKIADVRPNDAVGES---VYYEKKQSCNPDQKFQCKNTRCVDKAALCNGYDDCGDFSDEVGPSSCPDPKPTFSVRLSGGRGNYEGRVEVKLFNEWGLMCDDGLNENLGKVVCNQLGFPMGYEKLTKNAKKEYGRGDG-KFLMGAVACRGTEASLYDCPHSGWKNIVNCTINNVAGIVCLWDRACTDKEFRCSG--RCIPLNQVCDGTQQCTDGADEESCGTPTLALRNGDGP--SSGFLEITRNGIAGAVCDDMFGDNEAKVVCAQLGIPGRFRLEPEGTFKTPGGTVMWLQDVKCSGSESSLFSCAIRNWGRSLCEIREAVNLRCGLPEPTRTTTQPPTTTTPARVTSSAK-TCGQRIGRFPAGRIINGYPAIRGQFPWQVGIRLKVSETDTRQHCGGTIINDRWIVTAAHCFDYPKSYYAIRVGDLDNMVTEEFERQFDIDLVFIHPQYSGQPSYDYDITLIRIQPDSKGYIEFNAAVQPACLPEKTLQTTRKTVCHISGWGSVGDMQLPRNLMAANVPLIANARCNQLYPGRITDRMQCAGFEAGGIDSCQGDSGGPLVCPIDGVYTLLGATSWGEGCAMPGSPGVYANIRNLRDWIDE 1225
BLAST of Neurotrypsin vs. TrEMBL
Match: A0A1I8IHJ7 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=3 SV=1) HSP 1 Score: 756.518 bits (1952), Expect = 0.000e+0 Identity = 460/1163 (39.55%), Postives = 656/1163 (56.41%), Query Frame = 1 Query: 337 GAPESPQIIRLRGE-NALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTG--NEKSLVDCPHDSTSYCS-GKSAGVSCVYNLGCPNGWISFNGACYQINTQQMDYKQADKFCQDHNSKLAFILKAKENNFISNVLYTQYKSIAQIWTGGYYAEVKLDEGRSEF-RWNWYSTIHNVDQWSTSNLWFPGFYETKTDKRPQGDPKTQSCVALNRAFADSQRQNTVYDVNYFWWDNLSCNEKLPFICQMNIPQSRSDCYEDNGLDYRGRISRTVQGSSCAKWTDPAATVNPQTNPEAGLGDHNFCRNPDNDLQPWCWTNPTNGVYGYCAIGKCSE------LPPPTATLKPQVTDPMGFGQGGCQSI-QYHCPSMISYNRQCIPKNEVCDKIPHCLGKEDEDHGFCKKYLCKENEFFCASDMFCILKTHVCDGKRNCADGSDE--KNCTVL-----DESALLKVYDKTD----SKILDVSDKLDYIDIPIDKCAEKCKILFHQFACKSFNYLPPHESRTHSECRLLT-KLASEEPYKLIAITYPGAHYSMKSDCTAEQ-FKCTRGMCIELSKKCDHRDNCGDNSDEIDCTTVT--FPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRS-HNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPE-GKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIV-LDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPT----AKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDS-HWCGASILSEDWIIGAAHCYARPKSDYRVRTGDWDNASDDKYEQVFEIEELILHPNWXXX-XXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPNSKCLVSGWGDTLST-YPEKLLAAEVPLIKHERCFEFYKGRLTERMQCAGYEAGGIDTCQGDSGGPLVCKVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKE 3714 G P SPQ RLRGE + + NEGRVEV + WGL C DY+ +ANV CR LGF++ A + + +G G++ D + ++C + +L C H+ CS +AGV C YN GC GW +++G CY++ + M + A K C+ +KL + EN+FI+N+LYT+++ IA WTGG YA + + E+ W + TIH V S S LWFPGF T++D RP G+ + QSC+A+++ F S + V D NYFWWDN+SC +LP+ICQ + SDCY +G +YRG +RT +G+ C W++ VN T+P GLG+HN CRNPD D +PWCW + V+GYC++ C E LP LKP + C S QY CPSMI+Y C+ + +VCD C+G EDE+ CI + VCD + +C G DE + C + ++ + K Y KT+ S I + + Y + + +C +C + +F C +F Y H + C LL K+A P + + +Y K C +Q F+C C++ + C+ D+CGD SDE+ ++ P F +RL+G YEG+VEV+ EWG +CDDG + +VVC QLGF E + + L+ + C GTE SL +C HS W++ NC + +AG+VC DRACT+ EFRCS CI LS+VCD T C+DG+DE G T+ + DGP SG +E++R G+ G VCDD + D +A V+C L IPGR + + F G ++ L ++KC+G E +L +C WG C +E + + CGLP+ T PT A+V +A CG R GR++ G+ A+ G FPWQVG+R KV + D+ CG +I+++ WI+ AAHC+ PKS Y +R GD DN +++E+ F+I+ + +HP ++ +YDYD LI+I+ + I+FN VQP CLP+ + + C +SGWG P L+AA VPLI + RC + Y GR+T+RMQCAG+EAGGID+CQGDSGGPLVC ++GVYT+ GATSWG GCA P +PGVYA I+ DWI E Sbjct: 96 GVPVSPQKARLRGELSHMNPNEGRVEVEYRGT--WGLACGDYFGREEANVYCRNLGFKKGANKPYGRSFFGTGNFKRWDILIGHVKCAAYRGQSNLFQCSHNLMPACSLNNTAGVECTYNEGCEFGWSAYDGLCYRVESGPMTAEDAAKACKAKGAKLVAVNSQGENSFITNMLYTKFQDIAAAWTGGQYARFR---DQLEYDAWTFKDTIHLVK--SDSKLWFPGF--TESDARPIGNKEKQSCIAISKIFYKSSERRDV-DTNYFWWDNISCKTELPYICQ-KLGTLTSDCYSQSGGNYRGEAARTDKGTPCQPWSE-NRLVNSMTHPGQGLGEHNLCRNPDGDTKPWCWVDNERNVFGYCSLRLCGEGEGGDGLP---TDLKPS------YNHSRCDSPDQYFCPSMINYRPTCVDRRQVCDSHKDCVGGEDEER------------------ELCIAISKVCDKQYDCDMGDDETPEACRLHKPEEESDAEVQKDYTKTEKVDESSIPSGTQSVSYYSLSLTQCKTRCDTM-DRFVCAAFIY--NHNATFGIRCTLLAQKIADVRPNDAVGES---VYYEKKQSCNPDQKFQCKNTRCVDKAALCNGYDDCGDFSDEVGPSSCPDPKPTFSVRLSGGRGNYEGRVEVKLFNEWGLMCDDGLNENLGKVVCNQLGFPMGYEKLSKNAKKEYGRGDGKFLMGAVACRGTEASLYDCPHSGWKNIVNCTINNVAGIVCLWDRACTDKEFRCSG--RCIPLSQVCDGTQQCTDGADEESCGTPTLALRNGDGP--SSGFLEITRNGIAGAVCDDMFGDNEAKVVCAQLGIPGRFRLEPEGTFKTPGGTVMWLQDVKCSGSESSLFSCAIRNWGRSLCEIREAVNLRCGLPEPTRTTTQPPTTTTPARVTSSA-KTCGQRIGRFPAGRIINGYPAIRGQFPWQVGIRLKVSETDTRQHCGGTIINDRWIVTAAHCFDYPKSYYAIRVGDLDNMVTEEFERQFDIDLVFIHPQYSGQPSYDYDITLIRIQPDSKGYIEFNAAVQPACLPEKTLQTTRKTVCHISGWGSVGDMQLPRNLMAANVPLIANARCNQLYPGRITDRMQCAGFEAGGIDSCQGDSGGPLVCPIDGVYTLLGATSWGEGCAMPGSPGVYANIRNLRDWIDE 1208
BLAST of Neurotrypsin vs. TrEMBL
Match: A0A267FEP6 (Uncharacterized protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig020209g1 PE=3 SV=1) HSP 1 Score: 744.577 bits (1921), Expect = 0.000e+0 Identity = 456/1184 (38.51%), Postives = 649/1184 (54.81%), Query Frame = 1 Query: 229 RQAVSEDETT--------FFDQNIPPLTGTGRSNTRFP----MRKVRDGAPESPQIIRLRGE-NALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCT--GNEKSLVDCPHDSTSYCS-GKSAGVSCVYNLGCPNGWISFNGACYQINTQQMDYKQADKFCQDHNSKLAFILKAKENNFISNVLYTQYKSIAQIWTGGYYAEVKLDEGRSEFRWNWYSTIHNVDQWSTSNLWFPGFYETKTDKRPQGDPKTQSCVALNRAFADSQRQNTVYDVNYFWWDNLSCNEKLPFICQMNIPQSRSDCYEDNGLDYRGRISRTVQGSSCAKWTDPAATVNPQTNPEAGLGDHNFCRNPDNDLQPWCWTNPTNGVYGYCAIGKCS-ELPPPTATLKPQVTDPM--GFGQGGCQSIQ-YHCPSMISYNRQCIPKNEVCDKIPHCLGKEDEDHGFCKKYLCKENEFFCASDMFCILKTHVCDGKRNCADGSDEKNCTVLDESALLKVYDKTDSKI---LDVSDKLDYIDIPID------------KCAEKCKILFHQFACKSFNYLPPHESRTHSECRLLTKLASEEPYKLIAITYPGAHYSMKSDCT-AEQFKCTRGMCIELSKKCDHRDNCGDNSDEID--CTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPW-RSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIV-LDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVD-----------DYDSHWCGASILSEDWIIGAAHCYA---RPKSDYRVRTGDWDNASDDKYEQVFEIEELILHPNWXX-XXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLG--MVPDPNSKCLVSGWGDTLS-TYPEKLLAAEVPLIKHERCFEFYK-GRLTERMQCAGYEAGGIDTCQGDSGGPLVCKV 3603 R A S ETT F D N P G R++ R G P +PQI+R+RG+ + NEGRVEV + +WGLVC DY ++A + C QLGF A + YG G + D V +QC G+E +L DC C + G+ C+YN GC GW SF+G CY++ T+ +A CQ +KL + +E N+I+N+LYT+++S+ +WTGG + + D G W + TIH Q LWFPGF E TD+RP GDP+ +SC+A+++ F + + + V DVNYFWWDN+SC +LPF+CQ + + +DCYE G +YRG +RT +G+ C W D +NP T P AGL H CRNPD D +PWCW + N V+GYC++ +CS ELP +PQ PM GFG C + + CPSM+SY C+ + +VCD C+GKEDED FC+ Y C + F+C CI VCDG +C G DE E A + V + ++++ ++ +D +P D +CA+ C L QF CKSF Y E R S+C LL + +P + +Y + C A+ F C C++ S+ C+ D+CGD SDEI+ C +E+ L+G + +EG++E+R + G VCDDG + A+V+C+QLG+ G I +A +FG+ + ++ + C ++ +C H PW S C +AG++C +DR C+ E RC D C LSK+CD DCSDG DE E + VTL+ + +G VE+SRGG++G VCDD + D++ V+CR L IPGR + +F AG ++ L +++C G E +L +C WGE C+ E + ++CGLP+ VT P A + + CG R + R+ GG + PWQV +R+KV S WCG +ILS+ WI+ AAHC+ PKS + VR GDW+N + D+YE+ F+++ LI H + YD+D +L++I+ + ++FN VQP CLP+ M DP SKCL+SGWG YPE L AEVPLI+ E C Y+ +TERM CAGY+ GGID CQGDSGGPLVCK+ Sbjct: 64 RHARSRRETTSPFIPLRLFGDSNPEPQPGYPRTSPDSEPDELSRHRTGGVPPTPQIVRIRGDLMKMNPNEGRVEV--NYHGVWGLVCGDYVQQIEATLVCHQLGFELGANRVYKNSYYGTGHYKRQDIIVGHVQCKHDGDELTLFDCKRKLMPPCDLNSTTGIECIYNTGCDWGWSSFDGLCYRLETEPKTAAEAAAACQAKGAKLVSVNSLEEGNYITNMLYTKFRSLNAVWTGGQFGSFR-DVGSQYTSWTFVDTIHMARQ----PLWFPGF-EPGTDQRPAGDPQQRSCIAMSKLFQNPRSRRDV-DVNYFWWDNISCKTRLPFVCQ-KLAVASADCYEGIGTEYRGLAARTDKGTPCQPWGD-NQLINPSTYPNAGLSGHGLCRNPDGDAKPWCWVDNKNNVFGYCSLRQCSDELP------QPQEGPPMTPGFGHEKCDRHEDFFCPSMLSYRPVCVVERQVCDGFVDCVGKEDEDEAFCRNYTCTSDHFYCRKFHKCISMDQVCDGLADCDLGDDET------EEACMSVKAQAEAELANEFQMTAGIDESSVPADAKLAIYYRKTLVQCAKHCDRL-EQFFCKSFIYYRTGEQRFQSKCFLLGSRIT-DPASKADPSIEAKYYEIPETCNDADDFLCNNSHCVKKSQACNGFDDCGDFSDEINSRCGKDPAKNYELVLSGGSDNHEGRIEIRLFNQRGLVCDDGLNAAMADVICQQLGYPGHERFILNAWQQFGRG-TGGFILSGVHCGPGAKNITDCAHRPWGDSGACSVKNVAGLICLIDRPCSMHEVRC--DSRCFPLSKMCDGVPDCSDGWDETECD-ILNVTLSH--NRTAGVVEISRGGIQGVVCDDHFSDEEVKVVCRHLGIPGRGALAQRGQFSTPAGVVMWLQDIRCEGTEASLFDCSLRDWGESTCSIDEAVQLLCGLPE--VTDPETTQAPQTDYSEI-CGKRLAPYSFYRIGGGRNSGITEVPWQVAIRKKVIRPAGLRKDIKLPSSSAWCGGTILSDRWILSAAHCFPYANMPKSAFVVRAGDWNNTAPDQYEREFDVDLLIQHERYTGPPAYDFDISLLRIKPDSRGYLEFNAGVQPACLPRQNQPMNYDPTSKCLISGWGSRGGFDYPEALQMAEVPLIRREVCDRMYEFENITERMFCAGYKEGGIDACQGDSGGPLVCKI 1213
BLAST of Neurotrypsin vs. Ensembl Cavefish
Match: prss12 (serine protease 12 [Source:ZFIN;Acc:ZDB-GENE-090313-45]) HSP 1 Score: 305.064 bits (780), Expect = 5.124e-87 Identity = 195/559 (34.88%), Postives = 292/559 (52.24%), Query Frame = 1 Query: 2086 CDHRDNCGDNSDEIDCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDSHW-CGASILSEDWIIGAAHCYARPKSD---YRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVG------IKFNNYVQPVCLP-KLGMVPDPNSKCLVSGWGDTLSTYPEKLLAAEVPLIKHERCFEFYKGRLTERMQCAG--YEAGGIDTCQGDSGGPLVC-KVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQT 3720 CDH ++ G + CT +T +RL G +EG++EV Y+G+WG VC+DG+ +VVC+QLG+ + + FG + P +L+D++ CTG E SL C S W H+C V C R G P ++ V L G + + GRVE+S GG GTVCDD + D+DA V+CR L G A+A FGEG G I +DN+KCTG E +L +C +G H C H ED GVIC + A V A CG +P ++ R++GG ++ G +PWQ VR + D CGA++++ W++ +AHC+ R + Y+VR GD+ ++ E+ + ++ +I+HP+++ + DYD AL+ + R+ G ++ + V PVCLP + VP ++ C ++GWGDT Y + L AEV ++ +C Y G T RM CAG + +D+C+GDSGGPLVC + G + ++G TSWG+ C PGVY K+ L WI++ T Sbjct: 303 CDHTEDAG-----VSCTPLT--DGSLRLVGGAAGFEGRLEVHYRGQWGTVCNDGWSTTNTQVVCRQLGY-------SVSPDMFGASSGP-ILLDDVICTGKEPSLTHCSRSDWLRHDCPHSNNVAVACSPQRT-----------------------------GHGVPT---SLPVRLVGGENEREGRVEISVGGQWGTVCDDGWTDQDAEVVCRQLGFSGLAKARVMAYFGEGEGPIHVDNVKCTGGERSLADCIKQPFGTHNCRHSEDAGVICNYGQQ------DNLAGVKDAVSSVCGLKPTHTRQKRIIGGENSLRGGWPWQAAVRLRGSQADGRLVCGATLINSCWVLTSAHCFKRYGNSTRMYKVRVGDYHTLVPEENEEEYGVDRIIIHPHYSAQSNDYDLALVHLIRHGGPEGRGGDCVRQSRSVLPVCLPGRRERVPKGSANCFITGWGDTGRAYSKTLQQAEVRVLSKRQCERRYAGHFTSRMLCAGAALDDRRVDSCRGDSGGPLVCERGGGGWVLYGITSWGHSCRLQDAPGVYTKVSAFLPWIRKIT 808 HSP 2 Score: 135.191 bits (339), Expect = 2.386e-31 Identity = 90/265 (33.96%), Postives = 124/265 (46.79%), Query Frame = 1 Query: 2113 NSDEIDCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVIC 2907 N T+ F P +RL+G + YEG+VEV + G+WG VCDD +D AEVVC+QLG G + A G R +L+DE+ CTG E S+E+C SPW HNC E AGV C +DGS + L G GR+E+ G GTVC+D + + V+CR L ++ FG +G I+LD++ CTG+E +L +C W H C H ++ V C Sbjct: 200 NRQAAAVTSAVFIP--VRLSGGQSVYEGRVEVYHAGQWGTVCDDQWDDNDAEVVCRQLGLGGTARAWARAYFGSGVGR---VLLDEVSCTGNELSIEQCSKSPWGEHNCDHTEDAGVSC-----------------------------TPLTDGS----------LRLVGGAAGFEGRLEVHYRGQWGTVCNDGWSTTNTQVVCRQL-----GYSVSPDMFGASSGPILLDDVICTGKEPSLTHCSRSDWLRHDCPHSNNVAVAC 415 HSP 3 Score: 120.939 bits (302), Expect = 5.917e-27 Identity = 89/252 (35.32%), Postives = 116/252 (46.03%), Query Frame = 1 Query: 2161 IRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLG-FLGAMESIHSAVNRFGKNRSPNLLVD--EIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVIC 2907 +RL G +K +G VEV G WG +C + +D K A VVC+QLG A + S V R P +V + C+G E L +C HS W C + A V T++ F + V L+ G GRVE+ G GTVCDD +DD DA V+CR L + G A+A FG G G ++LD + CTG EL++E C WGEH C H ED GV C Sbjct: 109 VRLQGGRSKLDGTVEVYLNGVWGTICSNDWDDKDATVVCRQLGQGYKARARVSSLV------RMPLSVVHWRTVGCSGEEGDLLQCPHSVWNGGECANRQAAAV--------TSAVF---------------------------------IPVRLSGGQSVYEGRVEVYHAGQWGTVCDDQWDDNDAEVVCRQLGLGGTARAWARAYFGSGVGRVLLDEVSCTGNELSIEQCSKSPWGEHNCDHTEDAGVSC 313 HSP 4 Score: 64.6994 bits (156), Expect = 1.291e-9 Identity = 47/124 (37.90%), Postives = 63/124 (50.81%), Query Frame = 1 Query: 322 RKVRDGAPESPQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDC---PHDSTSYCSGKSAGVSCVYN 684 ++ G P S + + GEN EGRVE+ S WG VCDD W DA V CRQLGF A+ A +G G+ ++ V ++CTG E+SL DC P + + + AGV C Y Sbjct: 418 QRTGHGVPTSLPVRLVGGENE---REGRVEI--SVGGQWGTVCDDGWTDQDAEVVCRQLGFSGLAK-ARVMAYFGEGEGPIH---VDNVKCTGGERSLADCIKQPFGTHNCRHSEDAGVICNYG 532 HSP 5 Score: 61.6178 bits (148), Expect = 1.048e-8 Identity = 45/116 (38.79%), Postives = 56/116 (48.28%), Query Frame = 1 Query: 340 APESPQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDC---PHDSTSYCSGKSAGVSCV 678 A S I +R + EGRVEVY + WG VCDD W+ DA V CRQLG AR R +G G V + ++ CTGNE S+ C P + + AGVSC Sbjct: 205 AVTSAVFIPVRLSGGQSVYEGRVEVYHAGQ--WGTVCDDQWDDNDAEVVCRQLGLGGTARAWARA-YFGSG---VGRVLLDEVSCTGNELSIEQCSKSPWGEHNCDHTEDAGVSCT 314 HSP 6 Score: 56.6102 bits (135), Expect = 3.217e-7 Identity = 30/77 (38.96%), Postives = 41/77 (53.25%), Query Frame = 1 Query: 1192 SDCYEDNGL--DYRGRISRTVQGSSCAKWTDPAATVNPQTNPEAGLGDHNFCRNPDNDLQPWCWTNPTNGV--YGYC 1410 ++C + G YRG I+ T G+SC WT+ + P GLG HN CRNPD ++PWC+ G +GYC Sbjct: 28 AECAQSRGRAGQYRGSIAVTESGASCMNWTEVSGV--SSRYPGKGLGHHNHCRNPDRRIRPWCFFRTGRGRIDWGYC 102
BLAST of Neurotrypsin vs. Ensembl Cavefish
Match: si:ch73-127m5.1 (si:ch73-127m5.1 [Source:ZFIN;Acc:ZDB-GENE-130531-25]) HSP 1 Score: 291.582 bits (745), Expect = 2.166e-82 Identity = 197/567 (34.74%), Postives = 294/567 (51.85%), Query Frame = 1 Query: 2071 ELS-KKCDHRDNCGDNSDEIDCTTVTFPPFE---IRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRG-RVVGGFEAVYGAFPWQVGVRQKVDDYDSH-WCGASILSEDWIIGAAHCYARPKSDYRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLP----KLGMVPDPNSKCLVSGWGDTLSTY-PEKLLAAEVPLIKHERCFEFYKGRLTER-MQCAGYEAGG----IDTCQGDSGGPLVCKVN-GVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQT 3720 ELS +C H N D ++ V+ P+ +RL N +EG++EV + G+WG VCDD + + A+VVC+QLGF G E + FG+ + +L+D+++C G+E+SL ECKHS W H+C E G+ C E KD + L G K GRVE+ G G+VCD ++D +AAV+CR L G ++A FG G G I L N++CTG+E +L CP H C H +D GV+C D V P+P + CG R +R R+VGG++++ G +PWQ + K S CGA++++ W++ AAHC+ R S Y V+ GD+ D +E+V +E + +H ++N ++++D ALI+++ +G + FN + CLP K G P + C+++GWG + Y P LL A VPL+ +C + Y R T M CAG + D+CQGDSGGPLVC+ G + + G SWG+GC P PGVY+++ L WI++ T Sbjct: 282 ELSLDECPHSGWEKHNCDHMEDAGVSCNPYTDGVVRLVDGDNPWEGRLEVYHSGDWGTVCDDNWTEQHAQVVCRQLGFRGGAEL--APAGMFGEG-AGLILLDDVQCEGSESSLLECKHSVWGRHDCSHSEDVGIRCHRGGEGLREEGGEKKD------------------------------MELVSGESRKEGRVEVFLNGEWGSVCDSGWNDVNAAVVCRQLGFTGVSKARPMGYFGAGKGPIHLANVRCTGKESSLGECPAKGSDSHVCKHGQDAGVVC---DYV----PEPETDIAIVGTHTCGIRGGAERRSKRIVGGYKSLRGDWPWQASLWLKSQSKGSQPLCGATLINSCWLLTAAHCFKRDASRYVVKLGDYHTEEQDDFERVLPLERVEVHRKYSNESWEHDVALIRLKGAEGKCVSFNPHTNAACLPAPGSKWGKRP---ASCVITGWGVSGKMYHPRTLLQAWVPLLPTWQCKKRYGERFTSHSMLCAGSMSSDHRHHADSCQGDSGGPLVCQGEAGRWVLTGVISWGHGCGDPSYPGVYSRVSRYLPWIEQVT 805 HSP 2 Score: 153.295 bits (386), Expect = 4.569e-37 Identity = 98/255 (38.43%), Postives = 131/255 (51.37%), Query Frame = 1 Query: 2143 TFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVIC 2907 T PP +RL G +EG+VEV + G WG +CDD +D AEVVC+QLG G ++ A FG+ P + +D ++CTG E SL+EC HS W HNC E AGV C N +DG V L DG + GR+E+ G GTVCDD++ ++ A V+CR L G A+ FGEGAG I+LD+++C G E +L C WG H C+H ED+G+ C Sbjct: 205 TGPP--LRLVGGEEDFEGRVEVYHDGRWGSICDDQWDDMDAEVVCRQLGLGGIPKAWSWA--HFGQGSGP-IQLDAVQCTGNELSLDECPHSGWEKHNCDHMEDAGVSC-----------------------------NPYTDGV----------VRLVDGDNPWEGRLEVYHSGDWGTVCDDNWTEQHAQVVCRQLGFRGGAELAPAGMFGEGAGLILLDDVQCEGSESSLLECKHSVWGRHDCSHSEDVGIRC 415 HSP 3 Score: 115.546 bits (288), Expect = 2.974e-25 Identity = 83/250 (33.20%), Postives = 117/250 (46.80%), Query Frame = 1 Query: 2161 IRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGF-LGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVIC 2907 +RL G + G++EV G+WG VCD + + A VVC+QLG G +++ + FG S + C G E SL EC+ + + +C AG+VC PEG + L G + GRVE+ G G++CDD +DD DA V+CR L + G +A FG+G+G I LD ++CTG EL+L+ CP W +H C H ED GV C Sbjct: 97 VRLVGGSSSKSGRLEVYLNGQWGSVCDTHWTDRDASVVCRQLGLGYGIPYTLNKQHSYFGPG-SGLFHYARLGCRGNERSLLECRSRKFVTSDCSHGSEAGLVCS------------------------------------PPEGT-GPPLRLVGGEEDFEGRVEVYHDGRWGSICDDQWDDMDAEVVCRQLGLGGIPKAWSWAHFGQGSGPIQLDAVQCTGNELSLDECPHSGWEKHNCDHMEDAGVSC 308 HSP 4 Score: 62.7734 bits (151), Expect = 4.894e-9 Identity = 35/78 (44.87%), Postives = 45/78 (57.69%), Query Frame = 1 Query: 397 EGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPH 630 EGRVEVY WG +CDD W+ +DA V CRQLG + A +G+G + + +QCTGNE SL +CPH Sbjct: 219 EGRVEVYHDGR--WGSICDDQWDDMDAEVVCRQLGLGGIPK-AWSWAHFGQGSGPIQ---LDAVQCTGNELSLDECPH 290 HSP 5 Score: 62.003 bits (149), Expect = 7.168e-9 Identity = 33/85 (38.82%), Postives = 51/85 (60.00%), Query Frame = 1 Query: 1153 LPFICQMNIPQSRSDCYEDNGLDYRGRISRTVQGSSCAKWTDPAATVNPQTNPEAGLGDHNFCRNPDNDLQPWCWTNPTNGVYGY 1407 +PF+ ++P S S+ + + G Y G +S+T GS C KWT+ V Q P GLG+H++CRNPD + PWC+ ++G G+ Sbjct: 7 VPFLL-FSVPLSCSEGFTELGY-YNGTVSQTDSGSPCLKWTEFPDYV--QQYPGRGLGEHSYCRNPDRESNPWCFFRQSSGAIGW 87 HSP 6 Score: 61.2326 bits (147), Expect = 1.254e-8 Identity = 40/97 (41.24%), Postives = 51/97 (52.58%), Query Frame = 1 Query: 343 PESPQIIRL-RGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPH 630 P + ++RL G+N EGR+EVY S WG VCDD W A V CRQLGFR A E +G G + +QC G+E SL++C H Sbjct: 310 PYTDGVVRLVDGDNPW---EGRLEVYHSGD--WGTVCDDNWTEQHAQVVCRQLGFRGGA-ELAPAGMFGEG---AGLILLDDVQCEGSESSLLECKH 397 HSP 7 Score: 59.6918 bits (143), Expect = 3.971e-8 Identity = 40/101 (39.60%), Postives = 55/101 (54.46%), Query Frame = 1 Query: 388 TANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCP---HDSTSYCSGKSAGVSCVY 681 + EGRVEV+ + WG VCD WN ++A V CRQLGF ++ A +G G ++ + ++CTG E SL +CP DS G+ AGV C Y Sbjct: 439 SRKEGRVEVFLNGE--WGSVCDSGWNDVNAAVVCRQLGFTGVSK-ARPMGYFGAGKGPIH---LANVRCTGKESSLGECPAKGSDSHVCKHGQDAGVVCDY 533 HSP 8 Score: 56.225 bits (134), Expect = 4.443e-7 Identity = 40/114 (35.09%), Postives = 59/114 (51.75%), Query Frame = 1 Query: 2608 VTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKR---FGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPP 2940 V L G +KSGR+E+ G G+VCD + D+DA+V+CR L + +K+ FG G+G L C G E +L C K+ C+H + G++C P+ T PP Sbjct: 97 VRLVGGSSSKSGRLEVYLNGQWGSVCDTHWTDRDASVVCRQLGLGYGIPYTLNKQHSYFGPGSGLFHYARLGCRGNERSLLECRSRKFVTSDCSHGSEAGLVCSPPEG--TGPP 208
BLAST of Neurotrypsin vs. Ensembl Cavefish
Match: si:ch211-51a6.2 (neurotrypsin-like [Source:NCBI gene;Acc:103031031]) HSP 1 Score: 290.426 bits (742), Expect = 7.467e-82 Identity = 201/564 (35.64%), Postives = 299/564 (53.01%), Query Frame = 1 Query: 2071 ELS-KKCDHRDNCGDNSDEIDCTTVTFPPFE---IRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFE-AVYGAFPWQVGVRQKVDDYDSH-WCGASILSEDWIIGAAHCYARPKSD---YRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGM--VPDPNSKCLVSGWGDTLSTYPEKLLAAEVPLIKHERCFEFYKGRLTERMQCAGYEAGG--IDTCQGDSGGPLVCK-VNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQT 3720 ELS ++C H N D ++ V+ P+ +RL G+ +EG++E+ + GEWG VCDD + A+VVC+QLG+ + A + + + +L+DE+KC G E SL EC+H+ W H+C E G+ C +RA +TND + P V+ L G K GRVE+ GL G+VCDD ++D +A V+CR L G ++A FGEG G I LDN++C G E +L CP H C H ED GVIC + V+QP ++ A CG RP +R R + G + ++ G +PWQV + + H CGA++++ W++ AAHC+ R +D Y +R GD+ D +E+ E + LH +++ ++ D AL++++ DG + FN + CLP V P + C+++GWG T S Y LL A +PL+ +C + Y R T RM CAG + +D+CQGDSGGPLVC+ NG +T+ G SWG+GC P PGVY ++ L WI++ T Sbjct: 306 ELSLEECPHMPWGQHNCDHMEDAGVSCNPYTDGVLRLVGADGPWEGRLEIYHSGEWGTVCDDNWTEHHAQVVCRQLGYSRGRAEV--APDGAYEEGTGMILLDEVKCRGDERSLLECEHAVWGRHDCSHSEDVGIRC--ERAV---------------------ETNDVP--AVPPVAGPLVR--LVAGESRKEGRVEVFINGLWGSVCDDGWNDINAGVVCRQLGFVGMSKARSMAYFGEGQGPIHLDNVRCVGTESSLGECPADGPNTHDCRHSEDAGVIC----DYVSQPADDSS----MAMQSCGLRPNTQRRRRRIIGGDKSLRGDWPWQVSLWLRAQSKRIHPLCGATLINSCWVVTAAHCFKRFGTDPSRYILRLGDYHTEERDDFERTLSPERIELHRKYHSQGWENDIALVRLKGTDGNCVSFNPHTNAACLPNQSAKKVKRP-AACVITGWGVTDSEYSRTLLQAWLPLLPSGKCKKRYGSRFTSRMLCAGSLSNHRRVDSCQGDSGGPLVCQGTNGRWTLTGVISWGHGCGDPSYPGVYTRVSRFLKWIEKVT 831 HSP 2 Score: 159.458 bits (402), Expect = 6.139e-39 Identity = 113/327 (34.56%), Postives = 156/327 (47.71%), Query Frame = 1 Query: 2074 LSKKCDHRDNCGDNSDEIDCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIP-GRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAF 3051 +S C+H + G + C +RL G + ++EG+VEV + G+WG +CDD +D AEVVC+QLG G ++ + FGK P +L+D ++CTG E SLEEC H PW HNC E AGV C N +DG +++ ADGP GR+E+ G GTVCDD++ + A V+CR L GRA+ D + EG G I+LD +KC G+E +L C WG H C+H ED+G+ C E P P P L G K GRV ++G+ Sbjct: 209 VSGDCNHGNEAG-----VVCAAPEGNGTPLRLVGGLEEFEGRVEVYHNGKWGTICDDHWDDIDAEVVCRQLGLGGVPKAW--TWSHFGKGSGP-ILLDGVQCTGNELSLEECPHMPWGQHNCDHMEDAGVSC-----------------------------NPYTDG--------VLRLVGADGP--WEGRLEIYHSGEWGTVCDDNWTEHHAQVVCRQLGYSRGRAEVAPDGAYEEGTGMILLDEVKCRGDERSLLECEHAVWGRHDCSHSEDVGIRCERAVETNDVPAVPPV-AGPLVRLVAGES---RKEGRVEVFINGLWGSV 484 HSP 3 Score: 127.487 bits (319), Expect = 5.662e-29 Identity = 91/250 (36.40%), Postives = 119/250 (47.60%), Query Frame = 1 Query: 2164 RLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNR--FGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVIC 2907 RL G + G++EV G WG VCD + A V+C+QLG + I +A+ FG S + + C G ENSL ECK + S +C AGVVC PEG T + L G + GRVE+ G GT+CDD +DD DA V+CR L + G +A FG+G+G I+LD ++CTG EL+LE CP WG+H C H ED GV C Sbjct: 125 RLIGGQSNKSGRLEVYLNGRWGTVCDTHLTDRDASVICRQLG----LGEIGTALQHSYFGPG-SGLFHYERLGCRGNENSLLECKSRKFVSGDCNHGNEAGVVCAA------------------------------------PEGNGT-PLRLVGGLEEFEGRVEVYHNGKWGTICDDHWDDIDAEVVCRQLGLGGVPKAWTWSHFGKGSGPILLDGVQCTGNELSLEECPHMPWGQHNCDHMEDAGVSC 332 HSP 4 Score: 67.3958 bits (163), Expect = 1.848e-10 Identity = 38/88 (43.18%), Postives = 50/88 (56.82%), Query Frame = 1 Query: 367 LRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPH 630 LR L EGRVEVY + WG +CDD+W+ +DA V CRQLG + T +G+G + + +QCTGNE SL +CPH Sbjct: 233 LRLVGGLEEFEGRVEVYHNGK--WGTICDDHWDDIDAEVVCRQLGLGGVPKAWT-WSHFGKGSGPI---LLDGVQCTGNELSLEECPH 314 HSP 5 Score: 63.5438 bits (153), Expect = 2.473e-9 Identity = 39/102 (38.24%), Postives = 53/102 (51.96%), Query Frame = 1 Query: 2614 LADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPD 2919 L G KSGR+E+ G GTVCD D+DA+VICR L + A++ FG G+G + L C G E +L C K+ C H + GV+C P+ Sbjct: 126 LIGGQSNKSGRLEVYLNGRWGTVCDTHLTDRDASVICRQLGLGEIGTALQHSYFGPGSGLFHYERLGCRGNENSLLECKSRKFVSGDCNHGNEAGVVCAAPE 227 HSP 6 Score: 62.7734 bits (151), Expect = 4.363e-9 Identity = 46/117 (39.32%), Postives = 65/117 (55.56%), Query Frame = 1 Query: 343 PESPQIIRL-RGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPHD--STSYC-SGKSAGVSCVY 681 P + ++RL GE + EGRVEV+ + LWG VCDD WN ++A V CRQLGF ++ A +G G ++ + ++C G E SL +CP D +T C + AGV C Y Sbjct: 454 PVAGPLVRLVAGE---SRKEGRVEVFING--LWGSVCDDGWNDINAGVVCRQLGFVGMSK-ARSMAYFGEGQGPIH---LDNVRCVGTESSLGECPADGPNTHDCRHSEDAGVICDY 561 HSP 7 Score: 62.003 bits (149), Expect = 8.521e-9 Identity = 35/96 (36.46%), Postives = 51/96 (53.12%), Query Frame = 1 Query: 343 PESPQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPH 630 P + ++RL G + EGR+E+Y S WG VCDD W A V CRQLG+ R E Y G + + +++C G+E+SL++C H Sbjct: 334 PYTDGVLRLVGADG--PWEGRLEIYHSGE--WGTVCDDNWTEHHAQVVCRQLGYSRGRAEVAPDGAYEEGTGMI---LLDEVKCRGDERSLLECEH 422 HSP 8 Score: 57.7658 bits (138), Expect = 1.738e-7 Identity = 31/80 (38.75%), Postives = 46/80 (57.50%), Query Frame = 1 Query: 1168 QMNIPQSRSDCYEDNGLDYRGRISRTVQGSSCAKWTDPAATVNPQTNPEAGLGDHNFCRNPDNDLQPWCWTNPTNGVYGY 1407 Q + P S S+ + + G Y G +S+T G C KWT+ + Q P+ GLGDH++CRNPD + PWC+ +G G+ Sbjct: 38 QSSGPLSCSEGFTELGY-YNGSVSQTDSGFPCLKWTEFPDYM--QQYPDRGLGDHSYCRNPDREANPWCFFRQRSGAIGW 114
BLAST of Neurotrypsin vs. Ensembl Cavefish
Match: si:ch73-127m5.1 (si:ch73-127m5.1 [Source:ZFIN;Acc:ZDB-GENE-130531-25]) HSP 1 Score: 282.337 bits (721), Expect = 1.466e-79 Identity = 196/570 (34.39%), Postives = 291/570 (51.05%), Query Frame = 1 Query: 2071 ELS-KKCDHRDNCGDNSDEIDCTTVTFPPFE---IRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRG-RVVGGFEAVYGAFPWQVGVRQKVDDYDSH-WCGASILSEDWIIGAAHCYARPKSD---YRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLP----KLGMVPDPNSKCLVSGWGDTLSTY-PEKLLAAEVPLIKHERCFEFYKGRLTER-MQCAGYEAGG----IDTCQGDSGGPLVCKVN-GVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQT 3720 ELS +C H N D ++ V+ P+ +RL N +EG++EV + G+WG VCDD + + A+VVC+QLGF F + +L+D+++C G+E+SL ECKHS W H+C E D +C S + C V V L G K GRVE+ G G+VCD ++D +AAV+CR L G ++A FG G G I L N++CTG+E +L CP H C H +D GV+C D V P+P + CG R +R R+VGG++++ G +PWQ + K S CGA++++ W++ AAHC+ R SD Y V+ GD+ D +E+V +E + +H ++N ++++D ALI+++ +G + FN + CLP K G P + C+++GWG + Y P LL A VPL+ +C + Y R T M CAG + D+CQGDSGGPLVC+ G + + G SWG+GC P PGVY+++ L WI++ T Sbjct: 271 ELSLDECPHSGWEKHNCDHMEDAGVSCNPYTDGVVRLVDGDNPWEGRLEVYHSGDWGTVCDDNWTEQHAQVVCRQLGFR----------YNFSAEGAGLILLDDVQCEGSESSLLECKHSVWGRHDCSHSE---------------------DVVCSSQATHC------------------VLVRLVSGESRKEGRVEVFLNGEWGSVCDSGWNDVNAAVVCRQLGFTGVSKARPMGYFGAGKGPIHLANVRCTGKESSLGECPAKGSDSHVCKHGQDAGVVC---DYV----PEPETDIAIVGTHTCGIRGGAERRSKRIVGGYKSLRGDWPWQASLWLKSQSKGSQPLCGATLINSCWLLTAAHCFKRSGSDASRYVVKLGDYHTEEQDDFERVLPLERVEVHRKYSNESWEHDVALIRLKGAEGKCVSFNPHTNAACLPAPGSKWGKRP---ASCVITGWGVSGKMYHPRTLLQAWVPLLPTWQCKKRYGERFTSHSMLCAGSMSSDHRHHADSCQGDSGGPLVCQGEAGRWVLTGVISWGHGCGDPSYPGVYSRVSRYLPWIEQVT 781 HSP 2 Score: 135.191 bits (339), Expect = 1.835e-31 Identity = 94/256 (36.72%), Postives = 126/256 (49.22%), Query Frame = 1 Query: 2128 DCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDI 2895 DCT PP +RL G +EG+VEV + G WG +CDD +D AEVVC+QLG G ++ A FG+ P + +D ++CTG E SL+EC HS W HNC E AGV C N +DG V L DG + GR+E+ G GTVCDD++ ++ A V+CR L + EGAG I+LD+++C G E +L C WG H C+H ED+ Sbjct: 192 DCTG---PP--LRLVGGEEDFEGRVEVYHDGRWGSICDDQWDDMDAEVVCRQLGLGGIPKAWSWA--HFGQGSGP-IQLDAVQCTGNELSLDECPHSGWEKHNCDHMEDAGVSC-----------------------------NPYTDGV----------VRLVDGDNPWEGRLEVYHSGDWGTVCDDNWTEQHAQVVCRQL-------GFRYNFSAEGAGLILLDDVQCEGSESSLLECKHSVWGRHDCSHSEDV 393 HSP 3 Score: 103.219 bits (256), Expect = 1.884e-21 Identity = 79/249 (31.73%), Postives = 108/249 (43.37%), Query Frame = 1 Query: 2161 IRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVIC 2907 +RL G + G++EV G+WG VCD + + A VVC+QLG A++ + FG S + C G E SL EC+ + V CT R L G + GRVE+ G G++CDD +DD DA V+CR L + G +A FG+G+G I LD ++CTG EL+L+ CP W +H C H ED GV C Sbjct: 107 VRLVGGSSSKSGRLEVYLNGQWGSVCDTHWTDRDASVVCRQLGLGYALQHSY-----FGPG-SGLFHYARLGCRGNERSLLECRSRKF----------------VTSDCTGPPLR------------------------------------LVGGEEDFEGRVEVYHDGRWGSICDDQWDDMDAEVVCRQLGLGGIPKAWSWAHFGQGSGPIQLDAVQCTGNELSLDECPHSGWEKHNCDHMEDAGVSC 297 HSP 4 Score: 62.7734 bits (151), Expect = 4.744e-9 Identity = 43/114 (37.72%), Postives = 55/114 (48.25%), Query Frame = 1 Query: 289 GTGRSNTRFPMRKVRDGAPESPQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPH 630 G RS RK P + + GE EGRVEVY WG +CDD W+ +DA V CRQLG + A +G+G + + +QCTGNE SL +CPH Sbjct: 175 GNERSLLECRSRKFVTSDCTGPPLRLVGGEEDF---EGRVEVYHDGR--WGSICDDQWDDMDAEVVCRQLGLGGIPK-AWSWAHFGQGSGPIQ---LDAVQCTGNELSLDECPH 279 HSP 5 Score: 62.3882 bits (150), Expect = 6.224e-9 Identity = 33/85 (38.82%), Postives = 51/85 (60.00%), Query Frame = 1 Query: 1153 LPFICQMNIPQSRSDCYEDNGLDYRGRISRTVQGSSCAKWTDPAATVNPQTNPEAGLGDHNFCRNPDNDLQPWCWTNPTNGVYGY 1407 +PF+ ++P S S+ + + G Y G +S+T GS C KWT+ V Q P GLG+H++CRNPD + PWC+ ++G G+ Sbjct: 17 VPFLL-FSVPLSCSEGFTELGY-YNGTVSQTDSGSPCLKWTEFPDYV--QQYPGRGLGEHSYCRNPDRESNPWCFFRQSSGAIGW 97 HSP 6 Score: 60.8474 bits (146), Expect = 1.923e-8 Identity = 41/117 (35.04%), Postives = 62/117 (52.99%), Query Frame = 1 Query: 340 APESPQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCP---HDSTSYCSGKSAGVSCVY 681 + ++ + +R + + EGRVEV+ + WG VCD WN ++A V CRQLGF ++ A +G G ++ + ++CTG E SL +CP DS G+ AGV C Y Sbjct: 396 SSQATHCVLVRLVSGESRKEGRVEVFLNGE--WGSVCDSGWNDVNAAVVCRQLGFTGVSK-ARPMGYFGAGKGPIH---LANVRCTGKESSLGECPAKGSDSHVCKHGQDAGVVCDY 506 HSP 7 Score: 56.225 bits (134), Expect = 4.660e-7 Identity = 39/97 (40.21%), Postives = 50/97 (51.55%), Query Frame = 1 Query: 343 PESPQIIRL-RGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPH 630 P + ++RL G+N EGR+EVY S WG VCDD W A V CRQLGFR G G ++D +QC G+E SL++C H Sbjct: 299 PYTDGVVRLVDGDNPW---EGRLEVYHSGD--WGTVCDDNWTEQHAQVVCRQLGFRYNFSAE------GAGLILLDD-----VQCEGSESSLLECKH 379 HSP 8 Score: 52.373 bits (124), Expect = 7.135e-6 Identity = 36/100 (36.00%), Postives = 53/100 (53.00%), Query Frame = 1 Query: 361 IRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPHDS--TSYCSG 654 +RL G + ++ GR+EVY + WG VCD +W DA+V CRQLG A + +G G + ++ C GNE+SL++C TS C+G Sbjct: 107 VRLVGGS--SSKSGRLEVYLNGQ--WGSVCDTHWTDRDASVVCRQLGLGY----ALQHSYFGPGS---GLFHYARLGCRGNERSLLECRSRKFVTSDCTG 195
BLAST of Neurotrypsin vs. Ensembl Cavefish
Match: si:ch73-127m5.1 (si:ch73-127m5.1 [Source:ZFIN;Acc:ZDB-GENE-130531-25]) HSP 1 Score: 278.87 bits (712), Expect = 1.012e-78 Identity = 194/567 (34.22%), Postives = 293/567 (51.68%), Query Frame = 1 Query: 2071 ELS-KKCDHRDNCGDNSDEIDCTTVTFPPFE---IRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRG-RVVGGFEAVYGAFPWQVGVRQKVDDYDSH-WCGASILSEDWIIGAAHCYARPKSDYRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLP----KLGMVPDPNSKCLVSGWGDTLSTY-PEKLLAAEVPLIKHERCFEFYKGRLTER-MQCAGYEAGG----IDTCQGDSGGPLVCKVN-GVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQT 3720 ELS +C H N D ++ V+ P+ +RL N +EG++EV + G+WG VCDD + + A+VVC+QLGF SA N + +L+D+++C G+E+SL ECKHS W H+C E G+ ++ T+ F + +S G K GRVE+ G G+VCD ++D +AAV+CR L G ++A FG G G I L N++CTG+E +L CP H C H +D GV+C D V P+P + CG R +R R+VGG++++ G +PWQ + K S CGA++++ W++ AAHC+ R S Y V+ GD+ D +E+V +E + +H ++N ++++D ALI+++ +G + FN + CLP K G P + C+++GWG + Y P LL A VPL+ +C + Y R T M CAG + D+CQGDSGGPLVC+ G + + G SWG+GC P PGVY+++ L WI++ T Sbjct: 214 ELSLDECPHSGWEKHNCDHMEDAGVSCNPYTDGVVRLVDGDNPWEGRLEVYHSGDWGTVCDDNWTEQHAQVVCRQLGF----RYNFSAGNCMFGEGAGLILLDDVQCEGSESSLLECKHSVWGRHDCSHSEDVGIPTYLN--LTSGWFWVLLGVLVRLVS----------------------------GESRKEGRVEVFLNGEWGSVCDSGWNDVNAAVVCRQLGFTGVSKARPMGYFGAGKGPIHLANVRCTGKESSLGECPAKGSDSHVCKHGQDAGVVC---DYV----PEPETDIAIVGTHTCGIRGGAERRSKRIVGGYKSLRGDWPWQASLWLKSQSKGSQPLCGATLINSCWLLTAAHCFKRDASRYVVKLGDYHTEEQDDFERVLPLERVEVHRKYSNESWEHDVALIRLKGAEGKCVSFNPHTNAACLPAPGSKWGKRP---ASCVITGWGVSGKMYHPRTLLQAWVPLLPTWQCKKRYGERFTSHSMLCAGSMSSDHRHHADSCQGDSGGPLVCQGEAGRWVLTGVISWGHGCGDPSYPGVYSRVSRYLPWIEQVT 736 HSP 2 Score: 147.132 bits (370), Expect = 2.999e-35 Identity = 98/258 (37.98%), Postives = 131/258 (50.78%), Query Frame = 1 Query: 2128 DCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGV 2901 DC T PP +RL G +EG+VEV + G WG +CDD +D AEVVC+QLG G ++ A FG+ P + +D ++CTG E SL+EC HS W HNC E AGV C N +DG V L DG + GR+E+ G GTVCDD++ ++ A V+CR L A + FGEGAG I+LD+++C G E +L C WG H C+H ED+G+ Sbjct: 132 DCHQGTGPP--LRLVGGEEDFEGRVEVYHDGRWGSICDDQWDDMDAEVVCRQLGLGGIPKAWSWA--HFGQGSGP-IQLDAVQCTGNELSLDECPHSGWEKHNCDHMEDAGVSC-----------------------------NPYTDGV----------VRLVDGDNPWEGRLEVYHSGDWGTVCDDNWTEQHAQVVCRQLGFRYNFSA-GNCMFGEGAGLILLDDVQCEGSESSLLECKHSVWGRHDCSHSEDVGI 344 HSP 3 Score: 82.0333 bits (201), Expect = 5.418e-15 Identity = 49/116 (42.24%), Postives = 66/116 (56.90%), Query Frame = 1 Query: 2560 DCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVIC 2907 DC G+ P + L G + GRVE+ G G++CDD +DD DA V+CR L + G +A FG+G+G I LD ++CTG EL+L+ CP W +H C H ED GV C Sbjct: 132 DCHQGTGPP-------LRLVGGEEDFEGRVEVYHDGRWGSICDDQWDDMDAEVVCRQLGLGGIPKAWSWAHFGQGSGPIQLDAVQCTGNELSLDECPHSGWEKHNCDHMEDAGVSC 240 HSP 4 Score: 62.7734 bits (151), Expect = 4.724e-9 Identity = 40/96 (41.67%), Postives = 52/96 (54.17%), Query Frame = 1 Query: 397 EGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPHDSTSYCS---GKSAGVSC 675 EGRVEVY WG +CDD W+ +DA V CRQLG + A +G+G + + +QCTGNE SL +CPH + + AGVSC Sbjct: 151 EGRVEVYHDGR--WGSICDDQWDDMDAEVVCRQLGLGGIPK-AWSWAHFGQGSGPIQ---LDAVQCTGNELSLDECPHSGWEKHNCDHMEDAGVSC 240 HSP 5 Score: 62.003 bits (149), Expect = 8.136e-9 Identity = 33/85 (38.82%), Postives = 51/85 (60.00%), Query Frame = 1 Query: 1153 LPFICQMNIPQSRSDCYEDNGLDYRGRISRTVQGSSCAKWTDPAATVNPQTNPEAGLGDHNFCRNPDNDLQPWCWTNPTNGVYGY 1407 +PF+ ++P S S+ + + G Y G +S+T GS C KWT+ V Q P GLG+H++CRNPD + PWC+ ++G G+ Sbjct: 48 VPFLL-FSVPLSCSEGFTELGY-YNGTVSQTDSGSPCLKWTEFPDYV--QQYPGRGLGEHSYCRNPDRESNPWCFFRQSSGAIGW 128 HSP 6 Score: 59.6918 bits (143), Expect = 4.296e-8 Identity = 40/101 (39.60%), Postives = 55/101 (54.46%), Query Frame = 1 Query: 388 TANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCP---HDSTSYCSGKSAGVSCVY 681 + EGRVEV+ + WG VCD WN ++A V CRQLGF ++ A +G G ++ + ++CTG E SL +CP DS G+ AGV C Y Sbjct: 370 SRKEGRVEVFLNGE--WGSVCDSGWNDVNAAVVCRQLGFTGVSK-ARPMGYFGAGKGPIH---LANVRCTGKESSLGECPAKGSDSHVCKHGQDAGVVCDY 464 HSP 7 Score: 58.9214 bits (141), Expect = 7.210e-8 Identity = 39/97 (40.21%), Postives = 50/97 (51.55%), Query Frame = 1 Query: 343 PESPQIIRL-RGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPH 630 P + ++RL G+N EGR+EVY S WG VCDD W A V CRQLGFR G G ++D +QC G+E SL++C H Sbjct: 242 PYTDGVVRLVDGDNPW---EGRLEVYHSGD--WGTVCDDNWTEQHAQVVCRQLGFRYNFSAGNCMFGEGAGLILLDD-----VQCEGSESSLLECKH 328
BLAST of Neurotrypsin vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006128.1 (pep scaffold:Pmarinus_7.0:GL484169:9759:12797:-1 gene:ENSPMAG00000005545.1 transcript:ENSPMAT00000006128.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 150.599 bits (379), Expect = 9.590e-41 Identity = 98/253 (38.74%), Postives = 131/253 (51.78%), Query Frame = 1 Query: 2980 CGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDSHWCGASILSEDWIIGAAHCYARPKSDY--RVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLP-KLGMVPDPNSKCLVSGWGDTL---STYPEKLLAAEVPLIKHERCFE-FYKGR-LTERMQCAGYEAGGIDTCQGDSGGPLVCK-VNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIK 3711 CG + R R+VGG A G +PWQ +R +Y SH CGAS++SE W++ AAHC+ + Y +V G D + + E+I H +N + DYD AL+++ + FN+ V P+CLP P P C +SGWG T S LL A + + HE C G +T RM C G+ AG I +CQGDSGGPL C+ + + + G TSWG GCA P P VY K L WIK Sbjct: 4 CGVQNSAGGRDRIVGGTPATSGKWPWQASLR----NYGSHVCGASLISERWLVAAAHCFMYSSNVYEWQVYLGI-TYIYDSANAVIVNVAEIITHERFNISTIDYDIALVRLSDP----VSFNHRVSPICLPPSTSHFPQPGKTCFISGWGRTSLAESGIHYDLLEAPMQIFSHEACSSNLMNGNFITTRMICIGHPAGAISSCQGDSGGPLACQGTDKAWYLSGVTSWGFGCALPMKPVVYTKTSKFLPWIK 247
BLAST of Neurotrypsin vs. Ensembl Sea Lamprey
Match: si:dkey-33m11.8 (si:dkey-33m11.8 [Source:ZFIN;Acc:ZDB-GENE-141215-49]) HSP 1 Score: 146.747 bits (369), Expect = 1.820e-39 Identity = 90/235 (38.30%), Postives = 123/235 (52.34%), Query Frame = 1 Query: 3013 RVVGGFEAVYGAFPWQVGVRQKVDDYDSHWCGASILSEDWIIGAAHCYARPKSDYRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPNSKCLVSGWGDTLS-TYPEKLLAAEVPLIKHERCFEFYKGRLTERMQCAGYEAGGIDTCQGDSGGPLVCKVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKE 3714 R+VGGFE + P+Q ++Q H+CG ++++ W++ AAHC D RV G+ + + EQ F +E I H ++ A D D L+K+ R N VQPV L + G + + CLVSGWG + P+ L A + C + Y G LT+ M CA Y AGG D CQGDSGGPL+C NG + G SWG GCA P PGVY K+ + WI+ Sbjct: 21 RIVGGFEVARNSLPYQASLQQN----GVHYCGGTLINAKWVLTAAHCEI-TSLDLRV-LGEHSLGNVEGKEQTFMVERAIRHAGYDPATVDNDIMLLKLPR----AAVLNAAVQPVQLARAGARLEDGTSCLVSGWGTVGNGVMPDALRAVYLDTTSRGYCNDAYSGTLTDNMFCAVYAAGGRDACQGDSGGPLIC--NG--ALNGIVSWGYGCAYPNYPGVYTKVSNYITWIEN 241
BLAST of Neurotrypsin vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002258.1 (pep scaffold:Pmarinus_7.0:GL487751:502724:507790:1 gene:ENSPMAG00000002029.1 transcript:ENSPMAT00000002258.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 145.976 bits (367), Expect = 5.896e-39 Identity = 90/254 (35.43%), Postives = 140/254 (55.12%), Query Frame = 1 Query: 2971 GLKCGH---RPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDSHWCGASILSEDWIIGAAHCYARPKSDYRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPNSKCLVSGWGDTL--STYPEKLLAAEV-PLIKHERCFEFYKGRLTERMQCAGYEAGGIDTCQGDSGGPLVCKVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKE 3714 G KCG +P++ RV+ G EAV G++PWQV ++ + D + H+CG SI+ W+I AAHC +P +++R+ G+ D +S+ + Q+ +E+ I HP ++ + D L+K++ F + V P+CLP+ P + V+GWG T + Y L V PLI E C +++ + + M CAG A G TC GDSGGPL + +G++ + G TSWGN P VY ++ +DWI E Sbjct: 16 GQKCGSPSIQPVISGFSRVINGEEAVPGSWPWQVSLQYE-DGF--HFCGGSIIDPYWVITAAHCDFKP-ANHRIIVGEHDKSSNVENIQILYVEKAITHPLYDANTINNDILLLKLKEPA----FFGDTVSPICLPRATDTFSPGTHAAVTGWGVTRWNANYGSSTLQQTVLPLISTEDCKKWWGSYIMDPMICAG--ANGHSTCMGDSGGPLTVQKDGMWVLAGLTSWGNSRCDTSVPVVYTRVTTFVDWIAE 259
BLAST of Neurotrypsin vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009259.1 (pep scaffold:Pmarinus_7.0:GL478809:471847:475891:1 gene:ENSPMAG00000008373.1 transcript:ENSPMAT00000009259.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 142.51 bits (358), Expect = 5.222e-38 Identity = 87/236 (36.86%), Postives = 123/236 (52.12%), Query Frame = 1 Query: 3013 RVVGGFEAVYGAFPWQVGVRQKVDDYDSHWCGASILSEDWIIGAAHCYARPKSDYRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPNSKCLVSGWGDTLSTY--PEKLLAAEVPLIKHERCFEFYKGRLTERMQCAGYEAGGIDTCQGDSGGPLVCKVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKE 3714 +VGG+E + PWQV + + H+CG S++S +W++ AAHCY + S VR G+ + + EQ + + I HP +++A D D LIK+ N Y Q V LP + C +SGWG+T ++ P+ L+ + P++ C Y G +T M C GY GG D+CQGDSGGP+VC NG + G SWG GCA P PGVY K+ WI Sbjct: 21 HIVGGYECAAHSQPWQVSL-----NIGYHFCGGSLISSEWVVSAAHCY-QTASRISVRIGEHNIFVTEGTEQRIQASKAIRHPQYSSATIDNDIMLIKLSSPA----TLNQYAQAVPLPSSCV--GTGVMCTISGWGETQTSVGSPDVLMCVQAPVLSDTSCRNSYPGDITNNMICLGYLEGGKDSCQGDSGGPVVC--NG--QLQGIVSWGRGCALPNYPGVYTKVCNYNSWIAS 240
BLAST of Neurotrypsin vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004829.1 (pep scaffold:Pmarinus_7.0:GL487651:3325:6603:-1 gene:ENSPMAG00000004392.1 transcript:ENSPMAT00000004829.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 141.739 bits (356), Expect = 9.387e-38 Identity = 87/236 (36.86%), Postives = 123/236 (52.12%), Query Frame = 1 Query: 3013 RVVGGFEAVYGAFPWQVGVRQKVDDYDSHWCGASILSEDWIIGAAHCYARPKSDYRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPNSKCLVSGWGDTLSTY--PEKLLAAEVPLIKHERCFEFYKGRLTERMQCAGYEAGGIDTCQGDSGGPLVCKVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKE 3714 +VGG+E + PWQV + + H+CG S++S +W++ AAHCY + S VR G+ + + EQ + + I HP +N+A D D LIK+ N Y Q + LP + C +SGWG+T ++ P+ L+ + P++ C Y G +T M C GY GG D+CQGDSGGP+VC NG + G SWG GCA P PGVY K+ WI Sbjct: 21 HIVGGYECAAHSQPWQVSL-----NIGYHFCGGSLISSEWVVSAAHCY-QTASRISVRIGEHNIFVTEGTEQRIQASKAIRHPQYNSATIDNDIMLIKLSSPA----TLNQYAQAIPLPSSCV--GTGVMCTISGWGETQTSVGSPDVLMCVQAPVLSDTSCRNSYPGDITNNMICLGYLEGGKDSCQGDSGGPVVC--NG--QLQGIVSWGRGCALPNYPGVYTKVCNYNSWIAS 240
BLAST of Neurotrypsin vs. Ensembl Nematostella
Match: EDO37083 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SGX1]) HSP 1 Score: 174.866 bits (442), Expect = 3.021e-48 Identity = 100/267 (37.45%), Postives = 147/267 (55.06%), Query Frame = 1 Query: 2929 TQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDSHWCGASILSEDWIIGAAHCYA-RPKSDYRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXX-XXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPNSKCLVSGWGDTLS--TYPEKLLAAEVPLIKHERCFEFYKGRLTERMQCAGYEAGGIDTCQGDSGGPLVCKVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQ 3717 T+PP PT + A+ CG RP R+VGG A G +PWQ +R +CG S++ W++ A HC + R +D +R G + ++ EQ ++E++I+HP + ALIK+ + N +V VCLP P ++C ++GWG S T P+ L A VP++ RC + Y G++ + M CAG + GGIDTCQGDSGGP+VC+ G + I GATSWG GCAQP GVYA ++ + W++ + Sbjct: 43 TRPPFPTTQAPVAS---CGVRPST----RIVGGTAAKQGDWPWQAQLR---STSGFPFCGGSLIHPQWVLTATHCVSSRRPTDLNIRLGAHNRRANLGMEQDIKVEKIIMHPGYRKPVGLAHDIALIKLLKP----ANLNRHVNLVCLPDAVPAPTDGTRCWITGWGRLASGGTAPDILQQASVPVVSRARCEKAYPGKIHDSMLCAGLDQGGIDTCQGDSGGPMVCESRGRFYIHGATSWGYGCAQPGKFGVYAHVKNLVAWVRSE 295
BLAST of Neurotrypsin vs. Ensembl Nematostella
Match: EDO31703 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SX50]) HSP 1 Score: 174.481 bits (441), Expect = 3.090e-48 Identity = 114/284 (40.14%), Postives = 162/284 (57.04%), Query Frame = 1 Query: 2902 ICGLPD--EVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVG---VRQKVDDYDSHWCGASILSEDWIIGAAHCYARPK--SDYRVRTGDWDNASDDKYEQVFEIEELILHPNWX-XXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPNSKCLVSGWGDTLSTY--PEKLLAAEVPLIKHERCFEFYKG---RLTERMQCAGYEAGGIDTCQGDSGGPLVCKVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKE 3714 C +P + T P+ +DP + +KCG + R+VGG A GA+PWQ+ V KV H CG S+++ +WI+ AAHC+A K DY + G+ D + D YEQ ++E +ILHP + + N+DYD ALIK+ +++N+ V+PVCLP L + N++C +SGWG P L A VPL+ + C + Y +++ RM+CAGY AGGID CQGDSGGPLVCK V+ + GA SWG GCA+ GVYA + W++ Sbjct: 11 FCTVPTTTQAPTTLPRTERPIDPGS-VKCGTKG--KGNTRIVGGTRAKKGAWPWQISMNYVHNKVTK-TPHICGGSVVAPEWIVTAAHCFAYSKDAKDYTIAVGEHDLNATDGYEQRPDVERIILHPKYAPHNNHDYDVALIKLASP----LQYNDRVRPVCLPSLKEDLEENTQCYISGWGHLQEAGHGPWVLHQAAVPLVSRDTCQKAYNDLHYKVSSRMRCAGYGAGGIDACQGDSGGPLVCKEGDVWYLMGAISWGVGCARGGRYGVYADMMDLKYWVQS 286
BLAST of Neurotrypsin vs. Ensembl Nematostella
Match: EDO42420 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S1T0]) HSP 1 Score: 171.014 bits (432), Expect = 1.463e-47 Identity = 95/244 (38.93%), Postives = 134/244 (54.92%), Query Frame = 1 Query: 2998 VHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDSHWCGASILSEDWIIGAAHCY-ARPKSDYRVRTGDWDNASDDKYEQVFEIEELILHPNWXX-XXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPNSKCLVSGWGDTLS--TYPEKLLAAEVPLIKHERCFEFYKGRLTERMQCAGYEAGGIDTCQGDSGGPLVCKVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQ 3717 V R+VGG A G +PWQ +R +CG +++ +W++ A HC S +R G EQ F + L+ HPN++ Y D AL+K++R K + YV CLP P +C ++GWG S + P+ L A VP++ RC + Y+G++ E M CAG +AGG+D CQGDSGGP+VC+ G + I GATSWGNGCA P GVYA+++ LDWIK + Sbjct: 12 VSHHARIVGGTTAQQGGWPWQAQLRTSTG---YPYCGGTLIHPEWVLTATHCLKGETASRVHIRLGAHRRTKGSGNEQDFRVIRLVTHPNYHRPVGYANDIALLKLDRP----AKLDRYVNFACLPDQVPEPKEGDRCYITGWGKLSSHGSAPDILQQATVPVVGRARCMKAYRGQIHESMLCAGLDAGGVDACQGDSGGPMVCENAGRFYIQGATSWGNGCAAPGKFGVYARVKYVLDWIKSE 248
BLAST of Neurotrypsin vs. Ensembl Nematostella
Match: EDO47761 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RKX8]) HSP 1 Score: 164.466 bits (415), Expect = 2.231e-45 Identity = 95/243 (39.09%), Postives = 140/243 (57.61%), Query Frame = 1 Query: 3013 RVVGGFEAVYGAFPWQVG-VRQKVDDYDSHWCGASILSEDWIIGAAHCY--ARPKSDYRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPNSKCLVSGWG---DTLSTYPEKLLAAEVPLIKHERCF--EFYKGRLTERMQCAGYEAGGIDTCQGDSGGPLVC---KVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWI 3708 R+VGG A GA+PWQV + K D + +CG S++ +W++ AAHC+ + KS Y +R G+ + D+ EQ F IE+ +HP ++ D D ALIK++R N V +CLP+ P +KC +SGWG + + + L+ A+VPL+ ++C + Y R+TE M CAG GG+D+CQGDSGGP VC + +T+ G TSWG GCA+ G+YA ++ L WI Sbjct: 1 RIVGGVVAKPGAWPWQVALIWAKGHDKGAQFCGGSLIDPEWVLTAAHCFEITKDKSQYMLRLGEHNFNEDEGTEQDFYIEKYYIHPKYDEKTTDNDMALIKLDRP----ATLNKRVNTICLPEADDEFKPGTKCTISGWGALQEGAGSTSKVLMQAKVPLVSRDQCSHQQSYGDRITENMLCAGMRQGGVDSCQGDSGGPFVCTNPENPRQWTLVGVTSWGKGCARALKYGIYANVRRYLHWI 239
BLAST of Neurotrypsin vs. Ensembl Nematostella
Match: EDO34807 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SNB8]) HSP 1 Score: 158.303 bits (399), Expect = 2.110e-43 Identity = 88/238 (36.97%), Postives = 136/238 (57.14%), Query Frame = 1 Query: 3013 RVVGGFEAVYGAFPWQVGVRQKVDDYDSHWCGASILSEDWIIGAAHCYARPK--SDYRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPNSKCLVSGWGDTL---STYPEKLLAAEVPLIKHERCFEFYKGRLTERMQCAGYEAGGIDTCQGDSGGPLVCKVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIK 3711 RV+GG +A+ GA+PWQ+ ++ + + CG S++S W++ AAHC AR + Y++ G+ + ++ E+ ++++I HP +NN D ALI++ K ++ V PVCLP G S+C ++GWG S++P L A +P + +C + + M CAG GGID CQGDSGGPLVC+ G + I GATSWG+GCA P GVYA ++ + W++ Sbjct: 2 RVIGGKDAIPGAWPWQIALKSRGNFI----CGGSLVSSTWVVTAAHCVARSSNPAQYQIIVGEHNRNVNEVTEETLNVKKVIAHPQYNNPRLSNDIALIELASPA----KLSSRVNPVCLPPHGYKLPAGSRCFITGWGKIKHPGSSHP-ILQQAMIPSLSEAQCKQKAQQSGCNSMLCAGLYNGGIDACQGDSGGPLVCETGGQFYIHGATSWGHGCAAPGKYGVYAHVKNLIGWVR 230
BLAST of Neurotrypsin vs. Ensembl Medaka
Match: prss12 (serine protease 12 [Source:NCBI gene;Acc:105358156]) HSP 1 Score: 323.939 bits (829), Expect = 3.875e-93 Identity = 270/883 (30.58%), Postives = 407/883 (46.09%), Query Frame = 1 Query: 1192 SDCYEDNGLD--YRGRISRTVQGSSCAKWTDPAATVNPQTNPEAGLGDHNFCRNPDNDLQPWCWTNPTNGV--YGYCAIGKCS-ELPPPTATLKPQVTDPMGFGQG-------GCQSIQYHCPSM---ISYNRQCIP-----KNEVCDKIPHCLGKEDEDHGFCKKYLCKENEFFCASDMFCILKTHVCDGKRNCADGSDEKNCTVLDESALLKVYDKTD-SKILDVSDKLDYIDIPIDKCAEKCKILFHQFACKSFNYLPPHESRTHSECRLLTKLASEEPYKLIAITYPGAHYSMKSDCTAEQF---KCTRGMCIELSKKCDHRDNCGDNSDEIDCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVN-----RFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDSHW-CGASILSEDWIIGAAHCYARPKSD---YRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIK-----IERNDGVGIKFNNYVQPVCLP-KLGMVPDPNSKCLVSGWGDTLSTYPEKLLAAEVPLIKHERCFEFYKGRLTERMQCAGYEAGG--IDTCQGDSGGPLVC-KVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKE 3714 +DC G D YRG I T GS C WT+ A + +P G+G+HN CRNPD+ ++PWC+ G +GYC + S L + L +V +G G G + C + IS + +P K + K HC G E+ D C K E A+ + CI + V G E TV +V+ I D D+ D D + C+ L A K++ +S G + + CT + +CT+ E C H ++ G + C +T RL G +EG++E+ YQG+WG VCDDG+ ++VVC+QLG+ + + RFG P +L+D++ CTG E SL C W H+C E + C N E +G P +++V LA G ++ GRVEL G GTVCDD + D+DA V+CR L G A+A FGEG G I +DN+ C G+E ++ +C G H C H ED GVIC D Q AK DPA L CG R + ++ R++GG ++ G +PWQ +R + D CGA+++ W++ +AHC+ R + Y+VR GD+ + ++YE+ + +++++ HP +++ + DYD AL+ + + G + F+ +V PVCLP + + S C ++GWGDT +Y + L A + L+ C ++Y T RM CAG +D+C+GDSGGPLVC + G + I+G TSWG+ C ++PGVY K+ WI++ Sbjct: 32 TDCVRSRGKDGFYRGSIDVTESGSRCMNWTEVAGF--QERHPGKGIGEHNHCRNPDSRIRPWCFFRNHKGRIDWGYCDCKQGSVRLQGGRSKLDGRVEVYLGGVWGSVCSNDWGDEDAAVVCRQLDEGISGRARAVPLFRTSKTRIHWKEVHCRG-EEPDLLHCSKSTWNGEECLTAAAVTCIQQKTVVTLPMRLIGGESESEGTV-------EVFHAGQWGSICD--DQWDDSDAEV-----VCRQLGLSGAAKAWGQAHFGKS-------------------------SGRVWLDEVRCTGNELSLEQCTKSAWGE--HNCLHSEDAG-----VSCHPLT--DGATRLVGGAGSHEGRLEIFYQGQWGTVCDDGWTKSNSQVVCRQLGYRTGETLLLEGPDIPPGPRFGVGSGP-ILLDDVNCTGKEPSLLLCSRREWLCHDCSHQEDVHIAC-------NPEI----------------------NGESLPA---SLRVRLAGGESSREGRVELYLFGQWGTVCDDGWTDQDAEVVCRQLGYSGAAKARLMAYFGEGTGPIHMDNVNCIGDERSIADCIKQMPGTHNCRHSEDAGVIC---DYGEPQHSTKEAK-DPAISL-CGLRLVHTRQRRIIGGENSLRGGWPWQAAIRLRGSKGDGRLVCGATLIDTCWVLTSAHCFKRYGNSTKLYKVRVGDYHSLVPEEYEEEYGVDKIVFHPRYHSHSNDYDLALVHLSPGAVRQTAGECVSFSRHVLPVCLPARKERLLKQASNCHITGWGDTGRSYSKTLQQAPLSLLPRRLCQQYYHSAFTSRMLCAGSVQSDRRVDSCRGDSGGPLVCERPGGGWVIYGVTSWGHACRTQQSPGVYTKVSAFSFWIRK 825 HSP 2 Score: 60.4622 bits (145), Expect = 2.634e-8 Identity = 41/114 (35.96%), Postives = 57/114 (50.00%), Query Frame = 1 Query: 352 PQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPHD--STSYCS-GKSAGVSCVYN 684 P +R+R ++ EGRVE+Y WG VCDD W DA V CRQLG+ A+ A +G G ++ + + C G+E+S+ DC T C + AGV C Y Sbjct: 444 PASLRVRLAGGESSREGRVELYLFGQ--WGTVCDDGWTDQDAEVVCRQLGYSGAAK-ARLMAYFGEGTGPIH---MDNVNCIGDERSIADCIKQMPGTHNCRHSEDAGVICDYG 551 HSP 3 Score: 55.0694 bits (131), Expect = 1.171e-6 Identity = 37/99 (37.37%), Postives = 53/99 (53.54%), Query Frame = 1 Query: 388 TANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPHDS---TSYCSGKSAGVSC 675 + +EG VEV+ + WG +CDD W+ DA V CRQLG A+ A Q +G+ S + +++CTGNE SL C + + + AGVSC Sbjct: 228 SESEGTVEVFHAGQ--WGSICDDQWDDSDAEVVCRQLGLSGAAK-AWGQAHFGK---SSGRVWLDEVRCTGNELSLEQCTKSAWGEHNCLHSEDAGVSC 320
BLAST of Neurotrypsin vs. Ensembl Medaka
Match: si:ch73-127m5.1 (neurotrypsin [Source:NCBI gene;Acc:101157816]) HSP 1 Score: 218.394 bits (555), Expect = 1.236e-57 Identity = 184/598 (30.77%), Postives = 271/598 (45.32%), Query Frame = 1 Query: 1984 IAITYPGAHYSMKSD-CTAEQFKCTRGMCIELSKKCDHRDNCGDNSDEIDCTTVTFPPFE---IRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYG--AFPWQVGV-RQKVDDYDSHWCGASILSEDWIIGAAHCYARPKSD---YRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLP-----KLGMVPDPNSKCLVSGWGDTLSTYPEKLLAAEVPLIKHERCFEFYKGRLTER-MQCAGYEAGGI----DTCQGDSGGPLVCK-VNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKE 3714 IA + AH+ S + KCT +C H D N D ++ V+ P+ +RL G + +EG+VEV + G+WG VCDD + + AEVVC+QLG+ G E + + FGK + +L+D++ C G+E SL +C+H W +C E GV C+V + +E IS S V L G K GRVE+ G G++CD ++D +AAV+CR L GRA A FG+G G I LD ++CTG+E L CP C +ED GV C P + K P L CG R +V G+ E +PWQV V Q + + C +++S W++ +A C +R SD Y VR G EQ E L+LH + + +D AL+K+ G + F+ CLP K G +P + +GW P+ ++A+ VPL+ +C + + + CA D CQG+SGG LVC+ +G + + G S G GCA P +P +Y ++ W+ E Sbjct: 277 IAKAWSWAHFGQGSGPILLDAVKCTGNEL--FLDQCSHGDWEQHNCDHMEDAGVSCSPYTDGVVRLVGGDSPWEGRVEVFHNGDWGTVCDDHWSQQHAEVVCRQLGYRGHAEVVTDGL--FGKG-AGLILLDDVHCEGSETSLLDCRHGIWGRTDCSHSEDVGVRCRVRSSQETNEVP------VISPST-------------------GPLVRLVGGSSRKEGRVEVYLHGDWGSICDSGWNDLNAAVVCRQLGHSGRATAAVG--FGQGKGPIHLDQVRCTGKEEFLGECPSLGQSIQGCGRREDAGVKCD------ATPHEAAVKTKPEE-LSCGLRKMVEVEGKKRNHEEESMSRTTWPWQVSVWLQSQKEGEGPLCSGTLISPCWVLTSAFCLSRFGSDPTIYVVRVG--------ASEQTLTPERLVLHRKFKGQSGGHDLALLKLPSTKGHCLTFDPNTNAACLPGTDGAKEGNIPASCVVMVTTGWAG-----PDSVVASWVPLMSPWQCKKRFGNSFSSHGTLCAASPPDTSLLRGDGCQGNSGGGLVCQDESGRWVLTGVVSGGYGCADPSSPALYTRVSRFRSWMDE 822 HSP 2 Score: 152.525 bits (384), Expect = 1.222e-36 Identity = 109/311 (35.05%), Postives = 147/311 (47.27%), Query Frame = 1 Query: 2107 GDNSDEIDCTTVTFPPF----EIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGG 3027 GD S + T V PP +RL +EG+VEV + G WG VCDD +D + AEVVC+QLGF G ++ A FG+ P +L+D +KCTG E L++C H W HNC E AGV C P V++ D P GRVE+ G GTVCDD + + A V+CR L G A+ + D FG+GAG I+LD++ C G E +L +C WG C+H ED+GV C + +Q + P+ G P+V R+VGG Sbjct: 209 GDCSHGNEATLVCAPPEGSGPPLRLVEGEEDFEGRVEVFHAGRWGTVCDDQWDDRDAEVVCRQLGFGGIAKAWSWA--HFGQGSGP-ILLDAVKCTGNELFLDQCSHGDWEQHNCDHMEDAGVSCS-------------------------------------PYTDGVVRLVGGDSP--WEGRVEVFHNGDWGTVCDDHWSQQHAEVVCRQLGYRGHAEVVTDGLFGKGAGLILLDDVHCEGSETSLLDCRHGIWGRTDCSHSEDVGVRCRVRS---SQETNEVPVISPSTG------PLV----RLVGG 464 HSP 3 Score: 111.694 bits (278), Expect = 4.800e-24 Identity = 82/248 (33.06%), Postives = 118/248 (47.58%), Query Frame = 1 Query: 2164 RLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVIC 2907 RL GS G+VE+ G+WG VC+ + + A V+C+QLGF ++ + +FG S + + C G E +L +C+ + + +C A +VC +GS P + L +G + GRVE+ G GTVCDD +DD+DA V+CR L G A+A FG+G+G I+LD +KCTG EL L+ C W +H C H ED GV C Sbjct: 123 RLVGSSISGSGRVEIYLNGQWGAVCNSHWTDRDASVICRQLGFGDIGTALQHS--QFGSG-SGLFHYERLGCRGDEGTLMKCQSRTFVTGDCSHGNEATLVCAP------------------------------PEGSGPP-------LRLVEGEEDFEGRVEVFHAGRWGTVCDDQWDDRDAEVVCRQLGFGGIAKAWSWAHFGQGSGPILLDAVKCTGNELFLDQCSHGDWEQHNCDHMEDAGVSC 330 HSP 4 Score: 63.929 bits (154), Expect = 2.379e-9 Identity = 37/97 (38.14%), Postives = 54/97 (55.67%), Query Frame = 1 Query: 340 APESPQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPH 630 +P + ++RL G + + EGRVEV+ + WG VCDD+W+ A V CRQLG+R A E +G+G + + C G+E SL+DC H Sbjct: 331 SPYTDGVVRLVGGD--SPWEGRVEVFHNGD--WGTVCDDHWSQQHAEVVCRQLGYRGHA-EVVTDGLFGKG---AGLILLDDVHCEGSETSLLDCRH 419 HSP 5 Score: 60.4622 bits (145), Expect = 2.419e-8 Identity = 42/115 (36.52%), Postives = 62/115 (53.91%), Query Frame = 1 Query: 340 APESPQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPH--DSTSYCSGKS-AGVSC 675 +P + ++RL G + + EGRVEVY WG +CD WN L+A V CRQLG +A A +G+G ++ + +++CTG E+ L +CP S C + AGV C Sbjct: 452 SPSTGPLVRLVGGS--SRKEGRVEVYLHGD--WGSICDSGWNDLNAAVVCRQLGHSGRATAAV---GFGQGKGPIH---LDQVRCTGKEEFLGECPSLGQSIQGCGRREDAGVKC 556 HSP 6 Score: 60.077 bits (144), Expect = 3.541e-8 Identity = 31/80 (38.75%), Postives = 47/80 (58.75%), Query Frame = 1 Query: 1168 QMNIPQSRSDCYEDNGLDYRGRISRTVQGSSCAKWTDPAATVNPQTNPEAGLGDHNFCRNPDNDLQPWCWTNPTNGVYGY 1407 Q ++P S S+ + + G Y G +S+T G+ C KWT+ V P GLGDH++CRNPD + PWC+ ++G G+ Sbjct: 36 QNSVPLSCSEGFTELGY-YNGTVSQTDSGAPCLKWTEFPDYV--MQYPGRGLGDHSYCRNPDRESNPWCFFRQSSGAIGW 112 HSP 7 Score: 57.7658 bits (138), Expect = 1.544e-7 Identity = 37/93 (39.78%), Postives = 50/93 (53.76%), Query Frame = 1 Query: 352 PQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPH 630 P + + GE EGRVEV+ ++ WG VCDD W+ DA V CRQLGF A+ A +G+G + + ++CTGNE L C H Sbjct: 229 PPLRLVEGEEDF---EGRVEVF--HAGRWGTVCDDQWDDRDAEVVCRQLGFGGIAK-AWSWAHFGQGSGPI---LLDAVKCTGNELFLDQCSH 312 HSP 8 Score: 55.0694 bits (131), Expect = 1.137e-6 Identity = 32/96 (33.33%), Postives = 50/96 (52.08%), Query Frame = 1 Query: 2632 AKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPD 2919 + SGRVE+ G G VC+ + D+DA+VICR L A++ +FG G+G + L C G+E L C + C+H + ++C P+ Sbjct: 130 SGSGRVEIYLNGQWGAVCNSHWTDRDASVICRQLGFGDIGTALQHSQFGSGSGLFHYERLGCRGDEGTLMKCQSRTFVTGDCSHGNEATLVCAPPE 225
BLAST of Neurotrypsin vs. Ensembl Medaka
Match: tmprss5 (transmembrane serine protease 5 [Source:NCBI gene;Acc:101167385]) HSP 1 Score: 162.54 bits (410), Expect = 3.929e-44 Identity = 95/247 (38.46%), Postives = 138/247 (55.87%), Query Frame = 1 Query: 2989 RPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDSHWCGASILSEDWIIGAAHCYARPKSDYRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPNSKCLVSGWGDTLS---TYPEKLLAAEVPLIKHERCFE--FYKGRLTERMQCAGYEAGGIDTCQGDSGGPLVCKVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKE 3714 + I K R++GG EA G +PWQV + H CG SI++ WI+ AAHC+ YR ++ + Q +++E++I + N+N+ +D D ALIK+ + F + ++P+CLP+ ++C +SGWG T P+ L A VPLI ++C Y G +T RM CAGY G +D CQGDSGGPLVC+ + V+ + G SWG GCA+P +PGVY K+ L WI E Sbjct: 14 QSITTKLPRIIGGAEAALGRWPWQVSLYYS----SRHTCGGSIITRQWIVTAAHCH------YRSEIQGFNQSLTAV--QRWKLEKIIYNKNYNHRTHDSDIALIKLR----TPLNFTDTIRPICLPQYKYDLPGGTQCWISGWGYTKPDDVQSPDTLKEAPVPLISTKKCNSSCMYNGEITPRMLCAGYTEGKVDACQGDSGGPLVCQEDTVWRLVGVVSWGTGCAEPNHPGVYTKVAEFLSWIYE 244
BLAST of Neurotrypsin vs. Ensembl Medaka
Match: tmprss5 (transmembrane serine protease 5 [Source:NCBI gene;Acc:101167385]) HSP 1 Score: 166.007 bits (419), Expect = 9.006e-44 Identity = 103/267 (38.58%), Postives = 144/267 (53.93%), Query Frame = 1 Query: 2947 TAKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDSHWCGASILSEDWIIGAAHC---YARPK-SDYRVRTGDWDNASDDKYEQV-FEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPNSKCLVSGWGDTLS---TYPEKLLAAEVPLIKHERCFE--FYKGRLTERMQCAGYEAGGIDTCQGDSGGPLVCKVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQ 3717 T KV +CG R K R++GG EA G +PWQV + H CG SI++ WI+ AAHC Y P+ S + V G +S + +E++I + N+N+ +D D ALIK+ + F + ++P+CLP+ ++C +SGWG T P+ L A VPLI ++C Y G +T RM CAGY G +D CQGDSGGPLVC+ + V+ + G SWG GCA+P +PGVY K+ L WI E Sbjct: 123 TGKVIALQCFECGTRA---KLPRIIGGAEAALGRWPWQVSLYYS----SRHTCGGSIITRQWIVTAAHCVHNYRLPQVSSWVVYAGIVTRSSAKMVQHTGHAVEKIIYNKNYNHRTHDSDIALIKLR----TPLNFTDTIRPICLPQYKYDLPGGTQCWISGWGYTKPDDVQSPDTLKEAPVPLISTKKCNSSCMYNGEITPRMLCAGYTEGKVDACQGDSGGPLVCQEDTVWRLVGVVSWGTGCAEPNHPGVYTKVAEFLSWIYEM 378
BLAST of Neurotrypsin vs. Ensembl Medaka
Match: ENSORLT00000007900.2 (trypsin-like [Source:NCBI gene;Acc:101170788]) HSP 1 Score: 157.532 bits (397), Expect = 1.579e-42 Identity = 92/239 (38.49%), Postives = 129/239 (53.97%), Query Frame = 1 Query: 3013 RVVGGFEAVYGAFPWQVGVRQKVDDYDSHWCGASILSEDWIIGAAHCYARPKSDYRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPNSKCLVSGWGDTLST-----YPEKLLAAEVPLIKHERCFEFYKGRLTERMQCAGYEAGGIDTCQGDSGGPLVCKVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKE 3714 ++VGGFE + P+QV + + +CG ++LSE W++ AAHC PKS+ VR G+ D + EQ + I HPN++ D D LIK+ N++V+P LP + + C +SGWG+ S+ YP+KL + PL+ E CF Y ++TE M CAGY GG D+CQGDSGGP+ C + G SWG+GCA PGVY K+ + WIKE Sbjct: 21 KIVGGFECQKNSVPYQVSLFTGYN-----YCGGTLLSEQWVLSAAHC--EPKSNLEVRLGEHDIWEPEGTEQHIMSAKFIRHPNYDPRTQDNDIMLIKLSEP----ATLNSFVRPAVLPS--KCENDGTMCRISGWGNIRSSDEGSRYPDKLQCLDAPLLSDETCFNAYPFQITENMICAGYLEGGKDSCQGDSGGPMTCDGE----LQGVVSWGHGCAMKNKPGVYTKVCNYVSWIKE 242
BLAST of Neurotrypsin vs. Planmine SMEST
Match: SMESG000016088.1 (SMESG000016088.1) HSP 1 Score: 2459.87 bits (6374), Expect = 0.000e+0 Identity = 1199/1204 (99.58%), Postives = 1202/1204 (99.83%), Query Frame = 1 Query: 115 MKLAVLAFCLVLTTNAAIIKSQYDKYDHFFQPSLTRHKRQAVSEDETTFFDQNIPPLTGTGRSNTRFPMRKVRDGAPESPQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPHDSTSYCSGKSAGVSCVYNLGCPNGWISFNGACYQINTQQMDYKQADKFCQDHNSKLAFILKAKENNFISNVLYTQYKSIAQIWTGGYYAEVKLDEGRSEFRWNWYSTIHNVDQWSTSNLWFPGFYETKTDKRPQGDPKTQSCVALNRAFADSQRQNTVYDVNYFWWDNLSCNEKLPFICQMNIPQSRSDCYEDNGLDYRGRISRTVQGSSCAKWTDPAATVNPQTNPEAGLGDHNFCRNPDNDLQPWCWTNPTNGVYGYCAIGKCSELPPPTATLKPQVTDPMGFGQGGCQSIQYHCPSMISYNRQCIPKNEVCDKIPHCLGKEDEDHGFCKKYLCKENEFFCASDMFCILKTHVCDGKRNCADGSDEKNCTVLDESALLKVYDKTDSKILDVSDKLDYIDIPIDKCAEKCKILFHQFACKSFNYLPPHESRTHSECRLLTKLASEEPYKLIAITYPGAHYSMKSDCTAEQFKCTRGMCIELSKKCDHRDNCGDNSDEIDCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDSHWCGASILSEDWIIGAAHCYARPKSDYRVRTGDWDNASDDKYEQVFEIEELILHPNWXXXXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPNSKCLVSGWGDTLSTYPEKLLAAEVPLIKHERCFEFYKGRLTERMQCAGYEAGGIDTCQGDSGGPLVCKVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQTGL 3726 MKLAVLAFCLVLTTNAAIIKSQY+KYD+FFQ SLTRHKRQAVSEDETTFFDQNIPPLTGTGRSNTRFPMRKVRDGAPESPQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPHDSTSYCSGKSAGVSCVYNLGCPNGWISFNGACYQINTQQMDYKQADKFCQDHNSKLAFILKAKENNFISNVLYTQYKSIAQIWTGGYYAEVKLDEGRSEFRWNWYSTIHNVDQWSTSNLWFPGFYETKTDKRPQGDPKTQSCVALNRAFADSQRQNTVYDVNYFWWDNLSCNEKLPFICQMNIPQSRSDCYEDNGLDYRGRISRTVQGSSCAKWTDPAATVNPQTNPEAGLGDHNFCRNPDNDLQPWCWTNPTNGVYGYCAIGKCSELPPPTATLKPQVTDPMGFGQGGCQSIQYHCPSMISYNRQCIPKNEVCDKIPHCLGKEDEDHGFCKKYLCKENEFFCASDMFCILKTHVCDGKRNCADGSDEKNCTVLDESALLKVYDKTDSKILDVSDKLDYIDIPIDKCAEKCKILFHQFACKSFNYLPPHESRTHSECRLLTKLASEEPYKLIAITYPGAHYSMKSDCTAEQFKCTRGMCIELSKKCDHRD+CGDNSDE DCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCDDDYDDKDAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDSHWCGASILSEDWIIGAAHCYARPKSDYRVRTGDWDNASDDKYEQVFEIEELILHPNWNNANYDYDYALIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPNSKCLVSGWGDTLSTYPEKLLAAEVPLIKHERCFEFYKGRLTERMQCAGYEAGGIDTCQGDSGGPLVCKVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQTGL Sbjct: 1 MKLAVLAFCLVLTTNAAIIKSQYEKYDNFFQASLTRHKRQAVSEDETTFFDQNIPPLTGTGRSNTRFPMRKVRDGAPESPQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPHDSTSYCSGKSAGVSCVYNLGCPNGWISFNGACYQINTQQMDYKQADKFCQDHNSKLAFILKAKENNFISNVLYTQYKSIAQIWTGGYYAEVKLDEGRSEFRWNWYSTIHNVDQWSTSNLWFPGFYETKTDKRPQGDPKTQSCVALNRAFADSQRQNTVYDVNYFWWDNLSCNEKLPFICQMNIPQSRSDCYEDNGLDYRGRISRTVQGSSCAKWTDPAATVNPQTNPEAGLGDHNFCRNPDNDLQPWCWTNPTNGVYGYCAIGKCSELPPPTATLKPQVTDPMGFGQGGCQSIQYHCPSMISYNRQCIPKNEVCDKIPHCLGKEDEDHGFCKKYLCKENEFFCASDMFCILKTHVCDGKRNCADGSDEKNCTVLDESALLKVYDKTDSKILDVSDKLDYIDIPIDKCAEKCKILFHQFACKSFNYLPPHESRTHSECRLLTKLASEEPYKLIAITYPGAHYSMKSDCTAEQFKCTRGMCIELSKKCDHRDDCGDNSDETDCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCDDDYDDKDAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLPDEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDSHWCGASILSEDWIIGAAHCYARPKSDYRVRTGDWDNASDDKYEQVFEIEELILHPNWNNANYDYDYALIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPNSKCLVSGWGDTLSTYPEKLLAAEVPLIKHERCFEFYKGRLTERMQCAGYEAGGIDTCQGDSGGPLVCKVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQTGL 1204
BLAST of Neurotrypsin vs. Planmine SMEST
Match: SMESG000016089.1 (SMESG000016089.1) HSP 1 Score: 1514.21 bits (3919), Expect = 0.000e+0 Identity = 722/1206 (59.87%), Postives = 914/1206 (75.79%), Query Frame = 1 Query: 121 LAVLAFCLVLTTNAAIIKSQYDKYDHFFQPSLTRHKRQAVSEDETTFFDQNIPPLTGTGRSNTRFPMRKVRDGAPESPQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPHDSTSYCSGKSAGVSCVYNLGCPNGWISFNGACYQINTQQMDYKQADKFCQDHNSKLAFILKAKENNFISNVLYTQYKSIAQIWTGGYYAEVKLDEGRSEFRWNWYSTIHNVDQWSTSNLWFPGFYETKTDKRPQGDPKTQSCVALNRAFADSQRQNTVYDVNYFWWDNLSCNEKLPFICQMNIPQSRSDCYEDNGLDYRGRISRTVQGSSCAKWTDPAATVNPQTNPEAGLGDHNFCRNPDNDLQPWCWTNPTNGVYGYCAIGKCSELPP-PTATLKPQVTDPMGFGQGGCQSIQYHCPSMISYNRQCIPKNEVCDKIPHCLGKEDEDHGFCKKYLCKENEFFCASDMFCILKTHVCDGKRNCADGSDEKNCTVLDESALLKVYDKTDSKILDVSDKLDYIDIPIDKCAEKCKILFHQFACKSFNYLPPHESRTHSECRLLTKLASEEPYKLIAITYPGAHYSMKSDCTAEQFKCTRGMCIELSKKCDHRDNCGDNSDEIDCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLP--DEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDSHWCGASILSEDWIIGAAHCYARPKSDYRVRTGDWDNASDDKYEQVFEIEELILHPNWXX-XXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPNSKCLVSGWGDTLSTYPEKLLAAEVPLIKHERCFEFYKGRLTERMQCAGYEAGGIDTCQGDSGGPLVCKVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQTGL 3726 + ++ FC T A +++ + F RHKRQA E TFF+ N + GRS + +P+R V DGAPE+P+ +R+R + ANEGRVEVY+S +K WGLVCDDYWN+ DANV+C+QLGF AREATRQD +GRG W+ DY + KI+C G+E S+ +C H+ +S CSG S+GVSC++N GC GW+SFNG CYQ+ + + +K+A+++C++ NSKLA+IL ENNF+SNVLY+Q+K I Q+WTGGYYA++K++ G+ RWNW STIHNVDQW+TS LWF G+ E K+DKRP GD K +SC+ALNR + DSQR N +YDVNYFWWDNLSCN KLPFICQ + R+DCYE NG YRG SRT QG+ CAKW++P+ TVN +T+P AGLGDHN+CRNPDND+ PWCW N GVYGYC + KCS+ P P T P+++DP G G GGC Q++CPSM SYNR+C+ + VCD++ C G EDE+ FCK + C+ NEF+C +D FCILK+++CDG+R+C+D +DEKNC++++E+ +L YDK SKIL V DK+ Y ++ +++C +KC++++ QF C+S NYLPP+E+R SEC L+ +L SE P L I YPG HYS+K+DCT ++KC+ GMCI LSK CD R++CGDNSDE++C +VTFPPFEIRLTGS N +EGKVE+RYQGEWG++CDD F I A V+CKQLGF+ A+E +H + +FGK R P +L+DE+KC GTE S+EEC H WR HNC+ +EIAGV+CKVDRACTN+EFRC KDK CI +S++CD DCSD SDEPEG+C + V L +GPD+ SGRVE+ R KGTVCDD + D +A+VICRML I GRAQA+ D RFG G G IVL N +C G E +L C FKWGEHKC+HKED GVICGLP + +T K + GL CG +PI +RGRVVGGFE VYGAFPWQVGVR +V DYD HWCG SILSEDWII A+HCY +PK+ Y VRTGDW+N D YEQ FEIEEL L+P + +D+D ALIKI+RN+G+GI FN++VQPVCLPK GMVPD +KCLVSGWGDTL EKLLAAEVPLIK ERC EFYK R+T+RMQCAGYEAGGIDTCQGDSGGPLVC+VNG+YTIFGATSWG+GCA P++PGVYAK+ LD++KE+TG Sbjct: 4 ILIIWFCACANTQAFQLENSENV---LFHSHFQRHKRQAPLGIEKTFFNDNPEVVITEGRSKSIYPIRSVLDGAPETPERLRIRSDGKSAANEGRVEVYNSKTKKWGLVCDDYWNLPDANVSCKQLGFVNAAREATRQDHHGRGKWTKKDYIIDKIKCLGSEASIFECSHEMSSTCSGGSSGVSCIFNGGCSYGWVSFNGVCYQVVNKILTFKKAEEYCKNQNSKLAYILDRNENNFLSNVLYSQFKKIHQVWTGGYYAKIKMNTGKIVKRWNWQSTIHNVDQWNTSYLWFQGYGEIKSDKRPLGDVKKKSCLALNRLYGDSQRSNEIYDVNYFWWDNLSCNTKLPFICQKITTRGRTDCYEGNGATYRGTTSRTNQGTKCAKWSNPSLTVNDKTHPNAGLGDHNYCRNPDNDIMPWCWVNTDVGVYGYCVMEKCSDKPSLPLVTELPRISDPPGKGNGGCADNQFYCPSMTSYNRKCLALSRVCDQVNDCSGLEDENPEFCKTFFCQANEFYCKADTFCILKSNICDGQRHCSDNADEKNCSIINETEILVKYDKFKSKILMVPDKIVYANLRLEECVQKCRVIYPQFGCRSLNYLPPNETRIFSECHLMKQLQSEIPDSLKHINYPGDHYSLKTDCTG-KYKCSSGMCIALSKSCDGRNDCGDNSDEMNCPSVTFPPFEIRLTGSKNDWEGKVEIRYQGEWGYICDDRFTISEAHVICKQLGFIEALEYVHGSGVKFGKVRDPIILLDELKCKGTEFSIEECPHDVWRKHNCKSEEIAGVICKVDRACTNTEFRCQKDKTCIKMSQMCDGKVDCSDRSDEPEGQCFLSVKLVNGPDSYSGRVEIQRSLSKGTVCDDGFTDSEASVICRMLGISGRAQAVTDTRFGSGVGEIVLSNPRCRGNETSLVQCNSFKWGEHKCSHKEDAGVICGLPILEHPITTTATSLKKSEQVPGLTCGRKPITQRRGRVVGGFETVYGAFPWQVGVRHRVGDYDIHWCGGSILSEDWIISASHCYEKPKNRYFVRTGDWNNNEMDIYEQSFEIEELFLNPKYKGPPTFDFDTALIKIKRNNGIGIIFNDHVQPVCLPKPGMVPDLKTKCLVSGWGDTLVETAEKLLAAEVPLIKAERCKEFYKDRITDRMQCAGYEAGGIDTCQGDSGGPLVCQVNGIYTIFGATSWGDGCAVPRSPGVYAKVDSMLDFVKEKTGF 1205
BLAST of Neurotrypsin vs. Planmine SMEST
Match: SMESG000016089.1 (SMESG000016089.1) HSP 1 Score: 1513.82 bits (3918), Expect = 0.000e+0 Identity = 722/1206 (59.87%), Postives = 914/1206 (75.79%), Query Frame = 1 Query: 121 LAVLAFCLVLTTNAAIIKSQYDKYDHFFQPSLTRHKRQAVSEDETTFFDQNIPPLTGTGRSNTRFPMRKVRDGAPESPQIIRLRGENALTANEGRVEVYDSNSKLWGLVCDDYWNILDANVTCRQLGFRRKAREATRQDRYGRGDWSVNDYTVHKIQCTGNEKSLVDCPHDSTSYCSGKSAGVSCVYNLGCPNGWISFNGACYQINTQQMDYKQADKFCQDHNSKLAFILKAKENNFISNVLYTQYKSIAQIWTGGYYAEVKLDEGRSEFRWNWYSTIHNVDQWSTSNLWFPGFYETKTDKRPQGDPKTQSCVALNRAFADSQRQNTVYDVNYFWWDNLSCNEKLPFICQMNIPQSRSDCYEDNGLDYRGRISRTVQGSSCAKWTDPAATVNPQTNPEAGLGDHNFCRNPDNDLQPWCWTNPTNGVYGYCAIGKCSELPP-PTATLKPQVTDPMGFGQGGCQSIQYHCPSMISYNRQCIPKNEVCDKIPHCLGKEDEDHGFCKKYLCKENEFFCASDMFCILKTHVCDGKRNCADGSDEKNCTVLDESALLKVYDKTDSKILDVSDKLDYIDIPIDKCAEKCKILFHQFACKSFNYLPPHESRTHSECRLLTKLASEEPYKLIAITYPGAHYSMKSDCTAEQFKCTRGMCIELSKKCDHRDNCGDNSDEIDCTTVTFPPFEIRLTGSVNKYEGKVEVRYQGEWGFVCDDGFDIKAAEVVCKQLGFLGAMESIHSAVNRFGKNRSPNLLVDEIKCTGTENSLEECKHSPWRSHNCRPDEIAGVVCKVDRACTNSEFRCSKDKMCISLSKVCDKTNDCSDGSDEPEGKCTVKVTLADGPDAKSGRVELSRGGLKGTVCXXXXXXXXAAVICRMLQIPGRAQAIKDKRFGEGAGAIVLDNLKCTGEELNLENCPFFKWGEHKCTHKEDIGVICGLP--DEVVTQPPKPTAKVDPAAGLKCGHRPIVHKRGRVVGGFEAVYGAFPWQVGVRQKVDDYDSHWCGASILSEDWIIGAAHCYARPKSDYRVRTGDWDNASDDKYEQVFEIEELILHPNWXX-XXXXXXXXLIKIERNDGVGIKFNNYVQPVCLPKLGMVPDPNSKCLVSGWGDTLSTYPEKLLAAEVPLIKHERCFEFYKGRLTERMQCAGYEAGGIDTCQGDSGGPLVCKVNGVYTIFGATSWGNGCAQPKNPGVYAKIQMQLDWIKEQTGL 3726 + ++ FC T A +++ + F RHKRQA E TFF+ N + GRS + +P+R V DGAPE+P+ +R+R + ANEGRVEVY+S +K WGLVCDDYWN+ DANV+C+QLGF AREATRQD +GRG W+ DY + KI+C G+E S+ +C H+ +S CSG S+GVSC++N GC GW+SFNG CYQ+ + + +K+A+++C++ NSKLA+IL ENNF+SNVLY+Q+K I Q+WTGGYYA++K++ G+ RWNW STIHNVDQW+TS LWF G+ E K+DKRP GD K +SC+ALNR + DSQR N +YDVNYFWWDNLSCN KLPFICQ + R+DCYE NG YRG SRT QG+ CAKW++P+ TVN +T+P AGLGDHN+CRNPDND+ PWCW N GVYGYC + KCS+ P P T P+++DP G G GGC Q++CPSM SYNR+C+ + VCD++ C G EDE+ FCK + C+ NEF+C +D FCILK+++CDG+R+C+D +DEKNC++++E+ +L YDK SKIL V DK+ Y ++ +++C +KC++++ QF C+S NYLPP+E+R SEC L+ +L SE P L I YPG HYS+K+DCT ++KC+ GMCI LSK CD R++CGDNSDE++C +VTFPPFEIRLTGS N +EGKVE+RYQGEWG++CDD F I A V+CKQLGF+ A+E +H + +FGK R P +L+DE+KC GTE S+EEC H WR HNC+ +EIAGV+CKVDRACTN+EFRC KDK CI +S++CD DCSD SDEPEG+C + V L +GPD+ SGRVE+ R KGTVCDD + D +A+VICRML I GRAQA+ D RFG G G IVL N +C G E +L C FKWGEHKC+HKED GVICGLP + +T K + GL CG +PI +RGRVVGGFE VYGAFPWQVGVR +V DYD HWCG SILSEDWII A+HCY +PK+ Y VRTGDW+N D YEQ FEIEEL L+P + +D+D ALIKI+RN+G+GI FN++VQPVCLPK GMVPD +KCLVSGWGDTL EKLLAAEVPLIK ERC EFYK R+T+RMQCAGYEAGGIDTCQGDSGGPLVC+VNG+YTIFGATSWG+GCA P++PGVYAK+ LD++KE+TG Sbjct: 5 ILIIWFCACANTQAFQLENSENV---LFHSHFQRHKRQAPLGIEKTFFNDNPEVVITEGRSKSIYPIRSVLDGAPETPERLRIRSDGKSAANEGRVEVYNSKTKKWGLVCDDYWNLPDANVSCKQLGFVNAAREATRQDHHGRGKWTKKDYIIDKIKCLGSEASIFECSHEMSSTCSGGSSGVSCIFNGGCSYGWVSFNGVCYQVVNKILTFKKAEEYCKNQNSKLAYILDRNENNFLSNVLYSQFKKIHQVWTGGYYAKIKMNTGKIVKRWNWQSTIHNVDQWNTSYLWFQGYGEIKSDKRPLGDVKKKSCLALNRLYGDSQRSNEIYDVNYFWWDNLSCNTKLPFICQKITTRGRTDCYEGNGATYRGTTSRTNQGTKCAKWSNPSLTVNDKTHPNAGLGDHNYCRNPDNDIMPWCWVNTDVGVYGYCVMEKCSDKPSLPLVTELPRISDPPGKGNGGCADNQFYCPSMTSYNRKCLALSRVCDQVNDCSGLEDENPEFCKTFFCQANEFYCKADTFCILKSNICDGQRHCSDNADEKNCSIINETEILVKYDKFKSKILMVPDKIVYANLRLEECVQKCRVIYPQFGCRSLNYLPPNETRIFSECHLMKQLQSEIPDSLKHINYPGDHYSLKTDCTG-KYKCSSGMCIALSKSCDGRNDCGDNSDEMNCPSVTFPPFEIRLTGSKNDWEGKVEIRYQGEWGYICDDRFTISEAHVICKQLGFIEALEYVHGSGVKFGKVRDPIILLDELKCKGTEFSIEECPHDVWRKHNCKSEEIAGVICKVDRACTNTEFRCQKDKTCIKMSQMCDGKVDCSDRSDEPEGQCFLSVKLVNGPDSYSGRVEIQRSLSKGTVCDDGFTDSEASVICRMLGISGRAQAVTDTRFGSGVGEIVLSNPRCRGNETSLVQCNSFKWGEHKCSHKEDAGVICGLPILEHPITTTATSLKKSEQVPGLTCGRKPITQRRGRVVGGFETVYGAFPWQVGVRHRVGDYDIHWCGGSILSEDWIISASHCYEKPKNRYFVRTGDWNNNEMDIYEQSFEIEELFLNPKYKGPPTFDFDTALIKIKRNNGIGIIFNDHVQPVCLPKPGMVPDLKTKCLVSGWGDTLVETAEKLLAAEVPLIKAERCKEFYKDRITDRMQCAGYEAGGIDTCQGDSGGPLVCQVNGIYTIFGATSWGDGCAVPRSPGVYAKVDSMLDFVKEKTGF 1206
BLAST of Neurotrypsin vs. Planmine SMEST
Match: SMESG000050479.1 (SMESG000050479.1) HSP 1 Score: 1036.94 bits (2680), Expect = 0.000e+0 Identity = 510/620 (82.26%), Postives = 537/620 (86.61%), Query Frame = -2 Query: 4252 ARSMKGINGNYVKSSLSASTMEYIDKNKKQNIRDFMTLKNLAKKNINICKFDKGNGIVILDHDVYVNKLNDLLNSPQFVKLPKGRKNGKLPPLKDEEFVQKMLNGFIEKKLIDEEVGKSIRPIGSQPAKLYGLPKIHKDGVPMRPVLSMVGTAQYKIAKFLDGLLKPLMRSEFECKDSFEFVSCIAKLQKRSMNDVMVSFDVCSLFTNVPLVETIDLCCALWNENDSEHHILDRRAFRKLLEFATSNVNFLFNDEWYQQIDGVAMGSPLAPTMASIFLASLEKKIASFQFEKPFVYKRYVDDIFLIFENQKHVEPFLHFMNSLHKNIVFTCETERKSSIAFLDLLIQRKDKQYETEIYRKPTDTGLYTSPESFCEFKYKRNMVKGLIYRSWALSSTFANSVKSVDKLVELLIKNGYSKSFLLLMIKETVDKLIKNPKDPCCGKSECNLSDGCELSVDLGDGKNGYKKIEPKYVLVLPYSEGFTNYKRKLGKLIGNLEYKIVSNSCKVRNMFINKSKTPVGLCSDLVYQFTCNGCNATYIGETSRHLQTRVQKHSRLRGVSNIIEHRKMCKGTTDLKDFKILYKNFNNKWERILGEALVIKSQSPKINVQSA--TNLLRLF 6105 +RS+KGIN NYVKSSLSASTMEYIDKNKKQNIRDFMTLKNLAKKNINICKFDKGNGIVILDHDVYVNKLNDLLNSPQFVKLPKGRKNGKLPPLKDEEFVQK+LNGFIEKKLIDE+VGKSIRPIGSQPAKLYGLPKIHKDGVPMRPVLSM F+ +EC LVETIDLCCALWNENDSEHHILD RAFRKL+EFATSNVNFLFNDEWYQQIDGVAMGSPLAPTMASIFLASLEKKIASFQFEKPFVYKRYVDDIFL FENQKHVEPFLHFMNSLHKN+VFTCETERKSSIAFLDLLIQRKDKQYETEIYRKPTDTGLYTSPESFCEF+YKRNMVKGLIYRSW+LSSTFANSVKSVDKLVELLIKNGYSKSFLLLMIKETVDKLIKNPKDPCCGKSECNLSDGCELSV LGDGKNG+KKIEPKYVLVLPYSEGFTNYKRKL K +GNLEYKIVSNSCKVRNMFINKSKTPVGLCSDLVY FTCNGCNATYIGETSRHL TRV H +L+G++NI EH + CK + DF+IL ++FNN WER++ EAL+I+S PKINVQSA TN+L +F Sbjct: 2377 SRSIKGINDNYVKSSLSASTMEYIDKNKKQNIRDFMTLKNLAKKNINICKFDKGNGIVILDHDVYVNKLNDLLNSPQFVKLPKGRKNGKLPPLKDEEFVQKILNGFIEKKLIDEKVGKSIRPIGSQPAKLYGLPKIHKDGVPMRPVLSM----------FV-----------YECT----------------------------------LVETIDLCCALWNENDSEHHILDGRAFRKLIEFATSNVNFLFNDEWYQQIDGVAMGSPLAPTMASIFLASLEKKIASFQFEKPFVYKRYVDDIFLEFENQKHVEPFLHFMNSLHKNLVFTCETERKSSIAFLDLLIQRKDKQYETEIYRKPTDTGLYTSPESFCEFRYKRNMVKGLIYRSWSLSSTFANSVKSVDKLVELLIKNGYSKSFLLLMIKETVDKLIKNPKDPCCGKSECNLSDGCELSVSLGDGKNGFKKIEPKYVLVLPYSEGFTNYKRKLSKQMGNLEYKIVSNSCKVRNMFINKSKTPVGLCSDLVYHFTCNGCNATYIGETSRHLCTRVLDHCQLKGLTNISEHNRGCKSEIGMSDFRILLRSFNNYWERVICEALLIRSLDPKINVQSAVTTNVLNVF 2941
BLAST of Neurotrypsin vs. Planmine SMEST
Match: SMESG000050479.1 (SMESG000050479.1) HSP 1 Score: 1036.17 bits (2678), Expect = 0.000e+0 Identity = 526/685 (76.79%), Postives = 565/685 (82.48%), Query Frame = -2 Query: 4252 KLINLRKIFGISKFSVENTVINLSKIVLNDDEERVLKFGPNHCIKN-RLDETKLCAKIESLYFHIARSMKGINGNYVKSSLSASTMEYIDKNKKQNIRDFMTLKNLAKKNINICKFDKGNGIVILDHDVYVNKLNDLLNSPQFVKLPKGRKNGKLPPLKDEEFVQKMLNGFIEKKLIDEEVGKSIRPIGSQPAKLYGLPKIHKDGVPMRPVLSMVGTAQYKIAKFLDGLLKPLMRSEFECKDSFEFVSCIAKLQKRSMNDVMVSFDVCSLFTNVPLVETIDLCCALWNENDSEHHILDRRAFRKLLEFATSNVNFLFNDEWYQQIDGVAMGSPLAPTMASIFLASLEKKIASFQFEKPFVYKRYVDDIFLIFENQKHVEPFLHFMNSLHKNIVFTCETERKSSIAFLDLLIQRKDKQYETEIYRKPTDTGLYTSPESFCEFKYKRNMVKGLIYRSWALSSTFANSVKSVDKLVELLIKNGYSKSFLLLMIKETVDKLIKNPKDPCCGKSECNLSDGCELSVDLGDGKNGYKKIEPKYVLVLPYSEGFTNYKRKLGKLIGNLEYKIVSNSCKVRNMFINKSKTPVGLCSDLVYQFTCNGCNATYIGETSRHLQTRVQKHSRLRGVSNIIEHRKMCKGTTDLKDFKILYKNFNNKWERILGEALVIKSQSPKINVQSA--TNLLRLF 6297 K +N+ K+ G + +++ + K DD + + N IKN D+ K A I L + +RS+KGIN NYVKSSLSASTMEYIDKNKKQNIRDFMTLKNLAKKNINICKFDKGNGIVILDHDVYVNKLNDLLNSPQFVKLPKGRKNGKLPPLKDEEFVQK+LNGFIEKKLIDE+VGKSIRPIGSQPAKLYGLPKIHKDGVPMRPVLSM F+ +EC LVETIDLCCALWNENDSEHHILD RAFRKL+EFATSNVNFLFNDEWYQQIDGVAMGSPLAPTMASIFLASLEKKIASFQFEKPFVYKRYVDDIFL FENQKHVEPFLHFMNSLHKN+VFTCETERKSSIAFLDLLIQRKDKQYETEIYRKPTDTGLYTSPESFCEF+YKRNMVKGLIYRSW+LSSTFANSVKSVDKLVELLIKNGYSKSFLLLMIKETVDKLIKNPKDPCCGKSECNLSDGCELSV LGDGKNG+KKIEPKYVLVLPYSEGFTNYKRKL K +GNLEYKIVSNSCKVRNMFINKSKTPVGLCSDLVY FTCNGCNATYIGETSRHL TRV H +L+G++NI EH + CK + DF+IL ++FNN WER++ EAL+I+S PKINVQSA TN+L +F Sbjct: 1357 KGLNVHKMLGEAVIHLDDIEF-VKKNSKKDDAVDLKAYEYNIQIKNIEDDDGKNIADILHL-MNKSRSIKGINDNYVKSSLSASTMEYIDKNKKQNIRDFMTLKNLAKKNINICKFDKGNGIVILDHDVYVNKLNDLLNSPQFVKLPKGRKNGKLPPLKDEEFVQKILNGFIEKKLIDEKVGKSIRPIGSQPAKLYGLPKIHKDGVPMRPVLSM----------FV-----------YECT----------------------------------LVETIDLCCALWNENDSEHHILDGRAFRKLIEFATSNVNFLFNDEWYQQIDGVAMGSPLAPTMASIFLASLEKKIASFQFEKPFVYKRYVDDIFLEFENQKHVEPFLHFMNSLHKNLVFTCETERKSSIAFLDLLIQRKDKQYETEIYRKPTDTGLYTSPESFCEFRYKRNMVKGLIYRSWSLSSTFANSVKSVDKLVELLIKNGYSKSFLLLMIKETVDKLIKNPKDPCCGKSECNLSDGCELSVSLGDGKNGFKKIEPKYVLVLPYSEGFTNYKRKLSKQMGNLEYKIVSNSCKVRNMFINKSKTPVGLCSDLVYHFTCNGCNATYIGETSRHLCTRVLDHCQLKGLTNISEHNRGCKSEIGMSDFRILLRSFNNYWERVICEALLIRSLDPKINVQSAVTTNVLNVF 1984 The following BLAST results are available for this feature:
BLAST of Neurotrypsin vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Neurotrypsin vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Neurotrypsin vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Neurotrypsin vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Neurotrypsin vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Neurotrypsin vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Neurotrypsin vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Neurotrypsin vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Neurotrypsin vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Neurotrypsin vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Neurotrypsin vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Neurotrypsin vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Neurotrypsin vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Neurotrypsin vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30032823 ID=SMED30032823|Name=Neurotrypsin|organism=Schmidtea mediterranea sexual|type=transcript|length=7054bpback to top protein sequence of SMED30032823-orf-1 >SMED30032823-orf-1 ID=SMED30032823-orf-1|Name=SMED30032823-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1205bp MKLAVLAFCLVLTTNAAIIKSQYDKYDHFFQPSLTRHKRQAVSEDETTFFback to top protein sequence of SMED30032823-orf-2 >SMED30032823-orf-2 ID=SMED30032823-orf-2|Name=SMED30032823-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=740bp MLESEKIRRTSIDKKLTNIGLMLNNATNEFCLQVCVEWCIKNSIVQIKSKback to top Annotated Terms
The following terms have been associated with this transcript:
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