Protein kinase domain-containing protein

Overview


Name	Protein kinase domain-containing protein
Smed ID	SMED30032587
Length (bp)	2861

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Protein kinase domain-containing protein (SMED30032587) t-SNE clustered cells

Violin plots show distribution of expression levels for Protein kinase domain-containing protein (SMED30032587) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Protein kinase domain-containing protein (SMED30032587) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Protein kinase domain-containing protein (SMED30032587) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30032587

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 4

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
protonephridia	SMED30032587	SMESG000056719.1	dd_Smed_v4_7028_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30032587	SMESG000056719.1	dd_Smed_v4_7028_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30032587	SMESG000056719.1	dd_Smed_v4_7028_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30032587	SMESG000056719.1	dd_Smed_v4_7028_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

Note: Hover over icons to view figure legend

Homology

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BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: DSTYK (dual serine/threonine and tyrosine protein kinase [Source:HGNC Symbol;Acc:HGNC:29043])

HSP 1 Score: 148.673 bits (374), Expect = 7.445e-36
Identity = 101/340 (29.71%), Postives = 163/340 (47.94%), Query Frame = 2

Query: 1784 KWKMKQAKKCLERCDFKILADEVCKNLLEEFYKKHNEFLAVMDLENFYVQKKIELSDEIRQKL-AEKAPIFAELLMLSLDVKGKYFLQNVEEKEEIGSGSQGTIHRCICDGKEL-AKKKYIVNIDXXXXXXXXXXXXXXXXHP--HLLPFLAVAIIDTEEIDSKEVAIYSPL--MKTDLYNYLCHNKTKLSHRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTID------MRLERLENIPL---ELWNLIEACWNADPEKRP 2758
            +WK K A++ +E      LA  +C          H  F A +         ++E ++++  ++  + AP  A L + S  ++     +  +  +E+G G  G ++ C   G       K +V  D        + + Y    P    L  L  ++ID        +A+   +  +  DLY  L    T L  R+ IA+ + E +++LHS  ++HRD+KL N+LL++ N   + D GFCK  A+   S VGTP+H+APE+     YD  VD+Y+F IL W++  G+ K P+   +F R  + D       R  R E +P+   E W L+EACW+ DP KRP
Sbjct:  563 EWKRKVAQEAIESLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLRVRKDHAPRLARLSLESCSLQDVLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGGGSSIAVLLIMERLHRDLYTGLKAGLT-LETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFT-GKYDNSVDVYAFGILFWYICSGSVKLPE---AFERCASKDHLWNNVRRGARPERLPVFDEECWQLMEACWDGDPLKRP 897

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BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: DSTYK (dual serine/threonine and tyrosine protein kinase [Source:HGNC Symbol;Acc:HGNC:29043])

HSP 1 Score: 111.309 bits (277), Expect = 2.826e-24
Identity = 89/333 (26.73%), Postives = 142/333 (42.64%), Query Frame = 2

Query: 1784 KWKMKQAKKCLERCDFKILADEVCKNLLEEFYKKHNEFLAVMDLENFYVQKKIELSDEIRQKL-AEKAPIFAELLMLSLDVKGKYFLQNVEEKEEIGSGSQGTIHRCICD---GKELAKKKYIVNIDXXXXXXXXXXXXXXXXHP--HLLPFLAVAIIDTEEIDSKEVAIYSPL--MKTDLYNYLCHNKTKLSHRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTIDMRLERLENIPLELWNLIEACWNADPEKRP 2758
            +WK K A++ +E      LA  +C          H  F A +         ++E ++++  ++  + AP  A L + S  ++     +  +  +E+G G  G ++  +CD   G      K +V  D        + + Y    P    L  L  ++ID        +A+   +  +  DLY  L    T L  R+ IA+ + E +++LHS  ++HRD+KL N+LL++ N   + D GFCK  A+   S VGTP+H+APE+                         TG  P                ERL     E W L+EACW+ DP KRP
Sbjct:  563 EWKRKVAQEAIESLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLRVRKDHAPRLARLSLESCSLQDVLLHRKPKLGQELGRGQYGVVY--LCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGGGSSIAVLLIMERLHRDLYTGLKAGLT-LETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELF------------------------TGARP----------------ERLPVFDEECWQLMEACWDGDPLKRP 852

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BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: FRK (fyn related Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:3955])

HSP 1 Score: 97.8265 bits (242), Expect = 1.683e-20
Identity = 66/215 (30.70%), Postives = 107/215 (49.77%), Query Frame = 2

Query: 2201 HPHLLPFLAVAIIDTEEIDSKEVAIYSPLMK-TDLYNYL---CHNKTKLSHRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGTPLHI-------APEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTI---DMRLERLENIPLELWNLIEACWNADPEKRPKSEYIIEKLNHIFET 2803
            HP L+   AV  ++        + I + LM+   L  YL     +K  L+ ++ +A Q+A  + YL S N +HRDL   N+L+ E N   +AD+G  +   + +     +   I       APE I  N +  K D++SF ILL+ +    GK P    +  +V+ +   + RL +  N P + +N++  CWNA+P++RP  E +  KL   FET
Sbjct:  286 HPKLIQLYAVCTLE------DPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIIT-YGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYFET 493

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BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: STK25 (serine/threonine kinase 25 [Source:HGNC Symbol;Acc:HGNC:11404])

HSP 1 Score: 90.8929 bits (224), Expect = 2.320e-20
Identity = 60/162 (37.04%), Postives = 87/162 (53.70%), Query Frame = 2

Query: 2348 SIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKS---TALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFH--RVMTIDMR-----LERLENIPLELWNLIEACWNADPEKRPKSEYIIEKLNHIFET 2803
            +I  +I + L YLHS   +HRD+K AN+LL+E   V LAD+G       T +   +FVGTP  +APE+I ++ YD+K DI+S  I    L++G   N    +  H  RV+ +  +     LE   + P +    +EAC N DP  RP ++   E L H F T
Sbjct:   25 TILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPN----SDLHPMRVLFLIPKNSPPTLEGQHSKPFK--EFVEACLNKDPRFRPTAK---ELLKHKFIT 177

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BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: NEK7 (NIMA related kinase 7 [Source:HGNC Symbol;Acc:HGNC:13386])

HSP 1 Score: 93.5893 bits (231), Expect = 4.476e-20
Identity = 83/295 (28.14%), Postives = 140/295 (47.46%), Query Frame = 2

Query: 1952 DEIRQKL-AEKAPIFAELLMLSLDVKGKYFLQNVEEKEEIGSGSQGTIHR--CICDGKELAKKKY----IVNIDXXXXXXXXXXXXXXXXHPHLLPFLAVAIIDTEEIDSKEVAIYSPLMKTDLYNYLCHNKTKLSHRI--SIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYG---FCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTIDMRLERLENIPL-------ELWNLIEACWNADPEKRPKSEYIIE 2779
            DE  Q +     P F     L  D+ G   L N   +++IG G    ++R  C+ DG  +A KK     +++  +  +  +EI       HP+++ + A  I D E     E+A    L +  +  +    K  +  R      +Q+  AL+++HS  +MHRD+K AN+ +     V L D G   F  S     +S VGTP +++PE I +N Y++K DI+S   LL+ ++    ++P      + + ++  ++E+ +  PL       EL  L+  C N DPEKRP   Y+ +
Sbjct:    2 DEQSQGMQGPPVPQFQPQKALRPDM-GYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDLSR--MIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMA--ALQSPFYGDKMN-LYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDVTYVYD 290

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BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: C18H7.4 (Tyrosine-protein kinase [Source:UniProtKB/TrEMBL;Acc:Q9GZG1])

HSP 1 Score: 95.9005 bits (237), Expect = 9.793e-21
Identity = 81/293 (27.65%), Postives = 141/293 (48.12%), Query Frame = 2

Query: 1973 AEKAPIFAELLMLSLDV-KGKYFL--QNVEEKEEIGSGSQGTIHRCICDGKELAKKKYIVNI----------DXXXXXXXXXXXXXXXXHPHLLPFLAVAIIDTEEIDSKEVAIYSPLMKTDLYNYLCHNKT--KLSHRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGTPLHI---APEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNP----KGATSFHRVMTIDMRLERLENIPLELWNLIEACWNADPEKRPKSEYIIEKL 2785
            AE   I  E ++L   + KGK+ L   +V  K++IGSG+ GT++R       L K   IV +          + + ++ +E      ++HP+++ F    + D   +   E      +        L  +K   K++ R+      A  + YLH  N +HRD+   N L++ +  V +AD+G C++TA+     +  PL++   APE+       Y  D+Y+F +++W       ++P    KG T   +V     R++  E +P ++ +L+  CWN DPEKRP +E + EKL
Sbjct:   94 AETIEIKGEKVILKRAIAKGKFQLMHTDVNFKKQIGSGAYGTVYR-----GRLVKTNAIVAVKKLDTEGTDEEGLTDMMKEARVMQLYDHPNIVKFYGYILDDVPYLLVLEFCNGGSVED------LLRDKPEIKINRRVQYTYMAACGMDYLHKKNCIHRDIASRNCLIH-NGVVKMADFGMCRATAVYKVD-LSKPLNVRWLAPEVWTNGETRYNTDVYAFGVMIWEFFITPYQSPYTEWKGYTVKQKVRG-GYRMQPPEGMPKDVASLLAECWNHDPEKRPNAEKLKEKL 372

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BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: src-2 (Tyrosine protein-kinase src-2 [Source:UniProtKB/Swiss-Prot;Acc:O45539])

HSP 1 Score: 89.3521 bits (220), Expect = 3.725e-18
Identity = 65/212 (30.66%), Postives = 103/212 (48.58%), Query Frame = 2

Query: 2201 HPHLLPFLAVAIIDTEEIDSKEVAIYSPLMKTDLYNYLCHN--KTKLSHRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCK-------STALTHYSFVGTPLH-IAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNP-KGATSFHRVMTIDM--RLERLENIPLELWNLIEACWNADPEKRPKSEYIIEKLNHIF 2797
            HP LL   AV   D      + + I + LM+ +L  +L     + ++   + I+ Q+A  + YL   N +HRDL   NIL+N   SV +AD+G  +         A T   F   P+   APE    N +  K D++SF ILL  +    G+ P  G T+   +  +D   R+      P+ L+++++ CW +DP+KRP  E +  KL  +F
Sbjct:  292 HPKLLSLYAVCTRD------EPILIVTELMQENLLTFLQRRGRQCQMPQLVEISAQVAAGMAYLEEMNFIHRDLAARNILINNSLSVKIADFGLARILMKENEYEARTGARF---PIKWTAPEAANYNRFTTKSDVWSFGILLTEIVT-FGRLPYPGMTNAEVLQQVDAGYRMPCPAGCPVTLYDIMQQCWRSDPDKRPTFETLQWKLEDLF 493

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BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: F32D8.1 (pep chromosome:WBcel235:V:10880837:10883399:1 gene:WBGene00009326.1 transcript:F32D8.1.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F32D8.1)

HSP 1 Score: 84.7297 bits (208), Expect = 2.572e-17
Identity = 54/188 (28.72%), Postives = 91/188 (48.40%), Query Frame = 2

Query: 2228 VAIIDTEEIDSKEVAIYSPLMKTDLYNYLCHN-KTKLSHRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTG--KNPKGATSFHRVMTIDMRLERLE--NIPLELWNLIEACWNADPEKRPKSEYII 2776
            ++IID    +++   ++      DLY  +  N + +      I +Q+A AL YLH  N++HRD+K  N+LL +  SV L D+G         Y   GTP + APE++ +  Y  + DI+S  ++L+ +  G    + P     F  +M     L+  E   I L+  +L+    N   E+RP +  I+
Sbjct:  130 ISIIDAFSTENQYFIVFEHAQYGDLYETIRKNGRIEEPDAAIITLQVASALNYLHERNVVHRDVKPENLLLVDKFSVKLCDFGLACHILGPLYRICGTPTYCAPEVLRETGYSTRCDIWSLGVVLYVMLVGYAPFRAPDQTRLFKLIMQAKPNLDMPEWKGISLKAKDLVSRLMNKTEERRPLASQIM 317

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BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: gck-1 (Germinal center kinase 1 [Source:UniProtKB/Swiss-Prot;Acc:H2L099])

HSP 1 Score: 86.2705 bits (212), Expect = 4.191e-17
Identity = 58/166 (34.94%), Postives = 85/166 (51.20%), Query Frame = 2

Query: 2336 SHRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKS---TALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTIDMRLERLENIPLEL----WN-----LIEACWNADPEKRPKSEYIIEKLNHIF 2797
            SH   I  +I + L+YLHS   +HRD+K AN+L++E   V +AD+G       T     +FVG+P  +APE+I +++YDYK DI+S  I    L+   G+ P       RV+ +  +     N P  L    W+      +E C N DPE RP +  +   L H F
Sbjct:  114 SHIAVILREILKGLEYLHSERKIHRDIKAANVLVSEHGDVKVADFGVAGQLTETVKKRITFVGSPFWMAPELIKQSSYDYKADIWSLGITAIELA--NGEPPHSDLHPMRVLFLIPK-----NPPPVLQGSQWSKPFKEFVEMCLNKDPENRPSASTL---LKHQF 269

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BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: gck-1 (Germinal center kinase 1 [Source:UniProtKB/Swiss-Prot;Acc:H2L099])

HSP 1 Score: 86.2705 bits (212), Expect = 4.280e-17
Identity = 58/166 (34.94%), Postives = 85/166 (51.20%), Query Frame = 2

Query: 2336 SHRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKS---TALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTIDMRLERLENIPLEL----WN-----LIEACWNADPEKRPKSEYIIEKLNHIF 2797
            SH   I  +I + L+YLHS   +HRD+K AN+L++E   V +AD+G       T     +FVG+P  +APE+I +++YDYK DI+S  I    L+   G+ P       RV+ +  +     N P  L    W+      +E C N DPE RP +  +   L H F
Sbjct:  129 SHIAVILREILKGLEYLHSERKIHRDIKAANVLVSEHGDVKVADFGVAGQLTETVKKRITFVGSPFWMAPELIKQSSYDYKADIWSLGITAIELA--NGEPPHSDLHPMRVLFLIPK-----NPPPVLQGSQWSKPFKEFVEMCLNKDPENRPSASTL---LKHQF 284

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BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: GckIII (gene:FBgn0266465 transcript:FBtr0083399)

HSP 1 Score: 90.8929 bits (224), Expect = 2.181e-18
Identity = 55/153 (35.95%), Postives = 83/153 (54.25%), Query Frame = 2

Query: 2360 QIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFC---KSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTIDMRLERL--ENIPLELW--------NLIEACWNADPEKRPKSEYIIE 2779
            ++ + L YLHS   +HRD+K AN+LL+E   V LAD+G      +T     +FVGTP  +APE+I ++ YD K DI+S  I    L++G   N    +  H      MR+  L  +N P +L         + +EAC N DPE RP ++ +++
Sbjct:  116 EVLKGLDYLHSERKLHRDIKAANVLLSEQGDVKLADFGVAGQLTNTTSKRNTFVGTPFWMAPEVIKQSQYDAKADIWSLGITAIELAKGEPPN----SELH-----PMRVLFLIPKNNPPQLTGSYTKSFKDFVEACLNKDPENRPTAKELLK 259

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BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: Btk29A (gene:FBgn0003502 transcript:FBtr0330693)

HSP 1 Score: 89.3521 bits (220), Expect = 3.804e-18
Identity = 95/385 (24.68%), Postives = 170/385 (44.16%), Query Frame = 2

Query: 1700 VIRSSIKGFLMTGLKIEFSQKSVDVKDPKWKMKQAKKCLERCDFKILADEVCKNLLEEF-YKKHNEFLAVMDLENFYVQKKIELSDEIRQKLAEKAPIFAELLMLSLDVKGKYFLQNVEEKEEIGSGSQGTIHRCICDGK-ELAKKKYIVNIDXXXXXXXXXXXXXXXXHPHLLPFLAVAIIDTEEIDSKEVAIY--SPLMK-TDLYNYLC-HNKTKLSHR---ISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGT---PLHIA-PEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTIDMR---LERLENIPLELWNLIEACWNADPEKRPKSEYIIEKLNHIFETI 2806
            V +SS KG     L  +  Q  V      + +KQ      RC++ +     C+ + +   Y +HN       L++    + +  +  +     E  P+  EL+++                EE+GSG  G + R    G  + A K       S ++  EE       +HP+L+    V         SK   IY  +  MK   L NYL  H KT + +    + + IQ+++ + YL  HN +HRDL   N L+  +N V +AD+G  +      Y+  G    P+  A PE++    +  K D++++ +L+W +    GK P G      V+    R   LE+ ++   E++++++ CW+  PE+RP    ++++L  + +T+
Sbjct:  113 VRKSSTKGLYTLSLHTKVPQSHVK----HYHIKQNA----RCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPM--ELMLM----------------EELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVC--------SKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFT-CGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALVAQTL 462

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BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: Btk29A (gene:FBgn0003502 transcript:FBtr0330692)

HSP 1 Score: 88.9669 bits (219), Expect = 6.372e-18
Identity = 95/385 (24.68%), Postives = 170/385 (44.16%), Query Frame = 2

Query: 1700 VIRSSIKGFLMTGLKIEFSQKSVDVKDPKWKMKQAKKCLERCDFKILADEVCKNLLEEF-YKKHNEFLAVMDLENFYVQKKIELSDEIRQKLAEKAPIFAELLMLSLDVKGKYFLQNVEEKEEIGSGSQGTIHRCICDGK-ELAKKKYIVNIDXXXXXXXXXXXXXXXXHPHLLPFLAVAIIDTEEIDSKEVAIY--SPLMK-TDLYNYLC-HNKTKLSHR---ISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGT---PLHIA-PEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTIDMR---LERLENIPLELWNLIEACWNADPEKRPKSEYIIEKLNHIFETI 2806
            V +SS KG     L  +  Q  V      + +KQ      RC++ +     C+ + +   Y +HN       L++    + +  +  +     E  P+  EL+++                EE+GSG  G + R    G  + A K       S ++  EE       +HP+L+    V         SK   IY  +  MK   L NYL  H KT + +    + + IQ+++ + YL  HN +HRDL   N L+  +N V +AD+G  +      Y+  G    P+  A PE++    +  K D++++ +L+W +    GK P G      V+    R   LE+ ++   E++++++ CW+  PE+RP    ++++L  + +T+
Sbjct:  214 VRKSSTKGLYTLSLHTKVPQSHVK----HYHIKQNA----RCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPM--ELMLM----------------EELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVC--------SKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFT-CGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALVAQTL 563

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BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: Btk29A (gene:FBgn0003502 transcript:FBtr0112835)

HSP 1 Score: 89.3521 bits (220), Expect = 6.440e-18
Identity = 95/385 (24.68%), Postives = 170/385 (44.16%), Query Frame = 2

Query: 1700 VIRSSIKGFLMTGLKIEFSQKSVDVKDPKWKMKQAKKCLERCDFKILADEVCKNLLEEF-YKKHNEFLAVMDLENFYVQKKIELSDEIRQKLAEKAPIFAELLMLSLDVKGKYFLQNVEEKEEIGSGSQGTIHRCICDGK-ELAKKKYIVNIDXXXXXXXXXXXXXXXXHPHLLPFLAVAIIDTEEIDSKEVAIY--SPLMK-TDLYNYLC-HNKTKLSHR---ISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGT---PLHIA-PEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTIDMR---LERLENIPLELWNLIEACWNADPEKRPKSEYIIEKLNHIFETI 2806
            V +SS KG     L  +  Q  V      + +KQ      RC++ +     C+ + +   Y +HN       L++    + +  +  +     E  P+  EL+++                EE+GSG  G + R    G  + A K       S ++  EE       +HP+L+    V         SK   IY  +  MK   L NYL  H KT + +    + + IQ+++ + YL  HN +HRDL   N L+  +N V +AD+G  +      Y+  G    P+  A PE++    +  K D++++ +L+W +    GK P G      V+    R   LE+ ++   E++++++ CW+  PE+RP    ++++L  + +T+
Sbjct:  252 VRKSSTKGLYTLSLHTKVPQSHVK----HYHIKQNA----RCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPM--ELMLM----------------EELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVC--------SKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFT-CGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALVAQTL 601

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: Btk29A (gene:FBgn0003502 transcript:FBtr0079618)

HSP 1 Score: 89.3521 bits (220), Expect = 6.440e-18
Identity = 95/385 (24.68%), Postives = 170/385 (44.16%), Query Frame = 2

Query: 1700 VIRSSIKGFLMTGLKIEFSQKSVDVKDPKWKMKQAKKCLERCDFKILADEVCKNLLEEF-YKKHNEFLAVMDLENFYVQKKIELSDEIRQKLAEKAPIFAELLMLSLDVKGKYFLQNVEEKEEIGSGSQGTIHRCICDGK-ELAKKKYIVNIDXXXXXXXXXXXXXXXXHPHLLPFLAVAIIDTEEIDSKEVAIY--SPLMK-TDLYNYLC-HNKTKLSHR---ISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGT---PLHIA-PEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTIDMR---LERLENIPLELWNLIEACWNADPEKRPKSEYIIEKLNHIFETI 2806
            V +SS KG     L  +  Q  V      + +KQ      RC++ +     C+ + +   Y +HN       L++    + +  +  +     E  P+  EL+++                EE+GSG  G + R    G  + A K       S ++  EE       +HP+L+    V         SK   IY  +  MK   L NYL  H KT + +    + + IQ+++ + YL  HN +HRDL   N L+  +N V +AD+G  +      Y+  G    P+  A PE++    +  K D++++ +L+W +    GK P G      V+    R   LE+ ++   E++++++ CW+  PE+RP    ++++L  + +T+
Sbjct:  252 VRKSSTKGLYTLSLHTKVPQSHVK----HYHIKQNA----RCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPM--ELMLM----------------EELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVC--------SKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFT-CGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALVAQTL 601

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: dstyk (dual serine/threonine and tyrosine protein kinase [Source:NCBI gene;Acc:402922])

HSP 1 Score: 151.369 bits (381), Expect = 5.263e-37
Identity = 106/358 (29.61%), Postives = 163/358 (45.53%), Query Frame = 2

Query: 1784 KWKMKQAKKCLERCDFKILADEVCKNLLEEFYKKHNEFLAVM-DLENFYVQKKIELSDEIRQKLAEKAPIFAELLMLSLDVKGKYFLQNVEEKEEIGSGSQGTIHRCICD---GKELAKKKYIVNIDXXXXXXXXXXXXXXXXHP--HLLPFLAVAIIDTEEIDSKEVAIYSPL--MKTDLYNYLCHNKTKLSHRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTIDM---------RLERLENIPLELWNLIEACWNADPEKRPKSEYIIEKLNHIFETI 2806
            +WK K A+  +E      LA  +C          H  F A +  LE  +  +     D   +   + AP  A L + S  ++        +   E+G G  G ++  +CD   G+     K +V  D        + + Y+   P    L  L  ++ID        +A+   +  +  DLY  L      L  R+ IA+ + E +++LHS  ++HRD+KL N+LL++ N   + D GFCK  A+   S VGTP+H+APE+     YD  VD+Y+F IL W+L  G+ K P+   +F +  + D          R ERL     E W L+EACWN DP +RP    +   L  I E +
Sbjct:  497 EWKRKVAQDAIESLSAAKLAKSICSQFRTRLNSSHEAFAASLRQLEEGHTGRLERTEDLWLRVRKDHAPRLARLSLESRSLRDILLHGKPKLGRELGRGQYGVVY--LCDSWAGRHPCALKSVVPPDDKHWNDLALEFHYTRSLPKHERLVNLHGSVIDHSYSGGSSIAVLLIMERLHRDLYTGL-KAGLSLKERLLIALDVVEGIRFLHSQGLLHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFT-GKYDNSVDVYAFGILFWYLCSGSVKLPE---AFEKCASKDQLWTNVKKGCRPERLPVFDEECWQLMEACWNGDPSQRPLLGIVQPGLQSIMERL 847

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: dstyk (dual serine/threonine and tyrosine protein kinase [Source:NCBI gene;Acc:402922])

HSP 1 Score: 151.369 bits (381), Expect = 6.103e-37
Identity = 106/358 (29.61%), Postives = 163/358 (45.53%), Query Frame = 2

Query: 1784 KWKMKQAKKCLERCDFKILADEVCKNLLEEFYKKHNEFLAVM-DLENFYVQKKIELSDEIRQKLAEKAPIFAELLMLSLDVKGKYFLQNVEEKEEIGSGSQGTIHRCICD---GKELAKKKYIVNIDXXXXXXXXXXXXXXXXHP--HLLPFLAVAIIDTEEIDSKEVAIYSPL--MKTDLYNYLCHNKTKLSHRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTIDM---------RLERLENIPLELWNLIEACWNADPEKRPKSEYIIEKLNHIFETI 2806
            +WK K A+  +E      LA  +C          H  F A +  LE  +  +     D   +   + AP  A L + S  ++        +   E+G G  G ++  +CD   G+     K +V  D        + + Y+   P    L  L  ++ID        +A+   +  +  DLY  L      L  R+ IA+ + E +++LHS  ++HRD+KL N+LL++ N   + D GFCK  A+   S VGTP+H+APE+     YD  VD+Y+F IL W+L  G+ K P+   +F +  + D          R ERL     E W L+EACWN DP +RP    +   L  I E +
Sbjct:  525 EWKRKVAQDAIESLSAAKLAKSICSQFRTRLNSSHEAFAASLRQLEEGHTGRLERTEDLWLRVRKDHAPRLARLSLESRSLRDILLHGKPKLGRELGRGQYGVVY--LCDSWAGRHPCALKSVVPPDDKHWNDLALEFHYTRSLPKHERLVNLHGSVIDHSYSGGSSIAVLLIMERLHRDLYTGL-KAGLSLKERLLIALDVVEGIRFLHSQGLLHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFT-GKYDNSVDVYAFGILFWYLCSGSVKLPE---AFEKCASKDQLWTNVKKGCRPERLPVFDEECWQLMEACWNGDPSQRPLLGIVQPGLQSIMERL 875

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: nek7 (NIMA-related kinase 7 [Source:ZFIN;Acc:ZDB-GENE-040801-136])

HSP 1 Score: 90.8929 bits (224), Expect = 2.037e-19
Identity = 53/160 (33.12%), Postives = 86/160 (53.75%), Query Frame = 2

Query: 2357 IQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYG---FCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTIDMRLERLENIPL-------ELWNLIEACWNADPEKRPKSEYIIEKLNHIFETI 2806
            +Q+  AL+++HS  IMHRD+K AN+ +     V L D G   F  S     +S VGTP +++PE I +N Y++K DI+S   LL+ ++    ++P      + + ++  ++E+ +  PL       EL  L++ C N DPEKRP   Y+     H+   I
Sbjct:  139 VQLCSALEHMHSRRIMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMA--ALQSPFYGDKMN-LYSLCKKIEQCDYPPLPSDHYSQELRKLVDMCINPDPEKRPDITYVYSMAKHMHGRI 295

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: map3k9 (mitogen-activated protein kinase kinase kinase 9 [Source:ZFIN;Acc:ZDB-GENE-081113-5])

HSP 1 Score: 93.5893 bits (231), Expect = 2.814e-19
Identity = 77/270 (28.52%), Postives = 120/270 (44.44%), Query Frame = 2

Query: 2057 KEEIGSGSQGTIHRCICDGKELAKKKYIVNIDXXXXXXXXXXXXXXX-----XHPHLLPFLAVAIIDTEEIDSKEVAIYSPLMKTDLYNYLCHNKTKLSHRISIAIQIAEALQYLHSHNI---MHRDLKLANILL-----NED---NSVFLADYGFCKST-ALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNP----KGATSFHRVMTIDMRLERLENIPLELWNLIEACWNADPEKRPKSEYIIEKLNHIFET 2803
            +E IG G  G ++R I +G+E+A K    + D       E     +       HP+++  L V + +       E A   PL +      L   +      +  A+QIA A+ YLH   I   +HRDLK +NIL+     N+D    ++ + D+G  +     T  S  GT   +APE+I  + +    D++S+ +LLW L   TG+ P     G    + V    + L      P     L+E CWN DP  RP    I+++L  I E+
Sbjct:  139 EEMIGVGGFGKVYRAIWNGQEVAVKAARRDPDEDVSQTLESVRQEAKLFAMLTHPNIMALLGVCLQEPNLCLVMEYARGGPLNRA-----LAGKRIPPHTLVDWAVQIARAMLYLHCQAIVPVIHRDLKSSNILILERVENDDLSNKTLKVTDFGLAREWHRTTKMSAAGTYAWMAPEVIRSSTFSKGSDVWSYGVLLWELL--TGEVPFRGIDGLAVAYGVAMNKLSLPIPSTCPEPFARLMEDCWNVDPHSRPPFTSILDQLTAIEES 401

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: stk25b (serine/threonine kinase 25b [Source:ZFIN;Acc:ZDB-GENE-040426-2537])

HSP 1 Score: 90.5077 bits (223), Expect = 5.419e-19
Identity = 60/162 (37.04%), Postives = 86/162 (53.09%), Query Frame = 2

Query: 2348 SIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKS---TALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFH--RVM-----TIDMRLERLENIPLELWNLIEACWNADPEKRPKSEYIIEKLNHIFET 2803
            +I  +I + L+YLHS   +HRD+K AN+LL+E   V LAD+G       T +   +FVGTP  +APE+I ++ YD+K DI+S  I    L++G   N    +  H  RV+          LE   + P +    +EAC N DP  RP ++   E L H F T
Sbjct:   30 TILREILKGLEYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPN----SDLHPMRVLFLIPKNTPPTLEGSYSKPFK--EFVEACLNKDPRFRPTAK---ELLKHKFIT 182

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: dstyk (dual serine/threonine and tyrosine protein kinase [Source:NCBI gene;Acc:493205])

HSP 1 Score: 147.132 bits (370), Expect = 1.921e-35
Identity = 100/343 (29.15%), Postives = 161/343 (46.94%), Query Frame = 2

Query: 1781 PKWKMKQAKKCLERCDFKILADEVCKNLLEEFYKKHNEFLAVMDLENFYVQKKIELSDEIRQKL-AEKAPIFAELLMLSLDVKGKYFLQNVEEKEEIGSGSQGTIHRCICDGKEL-AKKKYIVNIDXXXXXXXXXXXXXXXXHP--HLLPFLAVAIIDTEEIDSKEVAIY--SPLMKTDLYNYLCHNKTKLS--HRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTID---------MRLERLENIPLELWNLIEACWNADPEKRP 2758
            P+WK + A+  +E      LA  +C    +     H  F A +         ++E ++++  ++  + AP  A L + S  ++            E+G G  G ++ C   G       K +V  D        + + Y    P    L  L  ++ID        +A+   +  +  DLY  L   KT LS   R+ IA+ + E +++LH+  ++HRD+KL N+LL++ +   + D GFCK  A+   S VGTP+H+APE +    YD  VD+Y+F IL W++  G+ K P+   +F +  + D          R ERL     E W L+EACWN DP +RP
Sbjct:  542 PEWKRRVAQDAIESLSASKLAKSICSQFCKRLKSSHEAFAASLKQLEVGHSGRLEKTNDLWLRVRKDHAPRLARLSLESRSLQDVLLHGKPRIGRELGRGQYGVVYLCDSWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYSYGGGSSIAVLLITERLHRDLYVGL---KTGLSLETRLQIALDVVEGIRFLHNQGLVHRDIKLKNVLLDKKHRAKITDLGFCKPEAMMSGSIVGTPIHMAPE-LFSGKYDNSVDVYAFGILFWYICSGSVKLPE---AFEKCASKDHLWNNVRKGARPERLAIFDEECWKLMEACWNGDPSQRP 877

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: dstyk (dual serine/threonine and tyrosine protein kinase [Source:NCBI gene;Acc:493205])

HSP 1 Score: 147.132 bits (370), Expect = 1.990e-35
Identity = 100/343 (29.15%), Postives = 161/343 (46.94%), Query Frame = 2

Query: 1781 PKWKMKQAKKCLERCDFKILADEVCKNLLEEFYKKHNEFLAVMDLENFYVQKKIELSDEIRQKL-AEKAPIFAELLMLSLDVKGKYFLQNVEEKEEIGSGSQGTIHRCICDGKEL-AKKKYIVNIDXXXXXXXXXXXXXXXXHP--HLLPFLAVAIIDTEEIDSKEVAIY--SPLMKTDLYNYLCHNKTKLS--HRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTID---------MRLERLENIPLELWNLIEACWNADPEKRP 2758
            P+WK + A+  +E      LA  +C    +     H  F A +         ++E ++++  ++  + AP  A L + S  ++            E+G G  G ++ C   G       K +V  D        + + Y    P    L  L  ++ID        +A+   +  +  DLY  L   KT LS   R+ IA+ + E +++LH+  ++HRD+KL N+LL++ +   + D GFCK  A+   S VGTP+H+APE +    YD  VD+Y+F IL W++  G+ K P+   +F +  + D          R ERL     E W L+EACWN DP +RP
Sbjct:  535 PEWKRRVAQDAIESLSASKLAKSICSQFCKRLKSSHEAFAASLKQLEVGHSGRLEKTNDLWLRVRKDHAPRLARLSLESRSLQDVLLHGKPRIGRELGRGQYGVVYLCDSWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYSYGGGSSIAVLLITERLHRDLYVGL---KTGLSLETRLQIALDVVEGIRFLHNQGLVHRDIKLKNVLLDKKHRAKITDLGFCKPEAMMSGSIVGTPIHMAPE-LFSGKYDNSVDVYAFGILFWYICSGSVKLPE---AFEKCASKDHLWNNVRKGARPERLAIFDEECWKLMEACWNGDPSQRP 870

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: dstyk (dual serine/threonine and tyrosine protein kinase [Source:NCBI gene;Acc:493205])

HSP 1 Score: 146.362 bits (368), Expect = 2.454e-35
Identity = 100/343 (29.15%), Postives = 161/343 (46.94%), Query Frame = 2

Query: 1781 PKWKMKQAKKCLERCDFKILADEVCKNLLEEFYKKHNEFLAVMDLENFYVQKKIELSDEIRQKL-AEKAPIFAELLMLSLDVKGKYFLQNVEEKEEIGSGSQGTIHRCICDGKEL-AKKKYIVNIDXXXXXXXXXXXXXXXXHP--HLLPFLAVAIIDTEEIDSKEVAIY--SPLMKTDLYNYLCHNKTKLS--HRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTID---------MRLERLENIPLELWNLIEACWNADPEKRP 2758
            P+WK + A+  +E      LA  +C    +     H  F A +         ++E ++++  ++  + AP  A L + S  ++            E+G G  G ++ C   G       K +V  D        + + Y    P    L  L  ++ID        +A+   +  +  DLY  L   KT LS   R+ IA+ + E +++LH+  ++HRD+KL N+LL++ +   + D GFCK  A+   S VGTP+H+APE+     YD  VD+Y+F IL W++  G+ K P+   +F +  + D          R ERL     E W L+EACWN DP +RP
Sbjct:  474 PEWKRRVAQDAIESLSASKLAKSICSQFCKRLKSSHEAFAASLKQLEVGHSGRLEKTNDLWLRVRKDHAPRLARLSLESRSLQDVLLHGKPRIGRELGRGQYGVVYLCDSWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYSYGGGSSIAVLLITERLHRDLYVGL---KTGLSLETRLQIALDVVEGIRFLHNQGLVHRDIKLKNVLLDKKHRAKITDLGFCKPEAMMSGSIVGTPIHMAPELF-SGKYDNSVDVYAFGILFWYICSGSVKLPE---AFEKCASKDHLWNNVRKGARPERLAIFDEECWKLMEACWNGDPSQRP 809

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: dstyk (dual serine/threonine and tyrosine protein kinase [Source:NCBI gene;Acc:493205])

HSP 1 Score: 146.747 bits (369), Expect = 2.537e-35
Identity = 100/343 (29.15%), Postives = 161/343 (46.94%), Query Frame = 2

Query: 1781 PKWKMKQAKKCLERCDFKILADEVCKNLLEEFYKKHNEFLAVMDLENFYVQKKIELSDEIRQKL-AEKAPIFAELLMLSLDVKGKYFLQNVEEKEEIGSGSQGTIHRCICDGKEL-AKKKYIVNIDXXXXXXXXXXXXXXXXHP--HLLPFLAVAIIDTEEIDSKEVAIY--SPLMKTDLYNYLCHNKTKLS--HRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTID---------MRLERLENIPLELWNLIEACWNADPEKRP 2758
            P+WK + A+  +E      LA  +C    +     H  F A +         ++E ++++  ++  + AP  A L + S  ++            E+G G  G ++ C   G       K +V  D        + + Y    P    L  L  ++ID        +A+   +  +  DLY  L   KT LS   R+ IA+ + E +++LH+  ++HRD+KL N+LL++ +   + D GFCK  A+   S VGTP+H+APE+     YD  VD+Y+F IL W++  G+ K P+   +F +  + D          R ERL     E W L+EACWN DP +RP
Sbjct:  553 PEWKRRVAQDAIESLSASKLAKSICSQFCKRLKSSHEAFAASLKQLEVGHSGRLEKTNDLWLRVRKDHAPRLARLSLESRSLQDVLLHGKPRIGRELGRGQYGVVYLCDSWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYSYGGGSSIAVLLITERLHRDLYVGL---KTGLSLETRLQIALDVVEGIRFLHNQGLVHRDIKLKNVLLDKKHRAKITDLGFCKPEAMMSGSIVGTPIHMAPELF-SGKYDNSVDVYAFGILFWYICSGSVKLPE---AFEKCASKDHLWNNVRKGARPERLAIFDEECWKLMEACWNGDPSQRP 888

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: dstyk (dual serine/threonine and tyrosine protein kinase [Source:NCBI gene;Acc:493205])

HSP 1 Score: 146.747 bits (369), Expect = 2.594e-35
Identity = 100/343 (29.15%), Postives = 161/343 (46.94%), Query Frame = 2

Query: 1781 PKWKMKQAKKCLERCDFKILADEVCKNLLEEFYKKHNEFLAVMDLENFYVQKKIELSDEIRQKL-AEKAPIFAELLMLSLDVKGKYFLQNVEEKEEIGSGSQGTIHRCICDGKEL-AKKKYIVNIDXXXXXXXXXXXXXXXXHP--HLLPFLAVAIIDTEEIDSKEVAIY--SPLMKTDLYNYLCHNKTKLS--HRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTID---------MRLERLENIPLELWNLIEACWNADPEKRP 2758
            P+WK + A+  +E      LA  +C    +     H  F A +         ++E ++++  ++  + AP  A L + S  ++            E+G G  G ++ C   G       K +V  D        + + Y    P    L  L  ++ID        +A+   +  +  DLY  L   KT LS   R+ IA+ + E +++LH+  ++HRD+KL N+LL++ +   + D GFCK  A+   S VGTP+H+APE +    YD  VD+Y+F IL W++  G+ K P+   +F +  + D          R ERL     E W L+EACWN DP +RP
Sbjct:  559 PEWKRRVAQDAIESLSASKLAKSICSQFCKRLKSSHEAFAASLKQLEVGHSGRLEKTNDLWLRVRKDHAPRLARLSLESRSLQDVLLHGKPRIGRELGRGQYGVVYLCDSWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYSYGGGSSIAVLLITERLHRDLYVGL---KTGLSLETRLQIALDVVEGIRFLHNQGLVHRDIKLKNVLLDKKHRAKITDLGFCKPEAMMSGSIVGTPIHMAPE-LFSGKYDNSVDVYAFGILFWYICSGSVKLPE---AFEKCASKDHLWNNVRKGARPERLAIFDEECWKLMEACWNGDPSQRP 894

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Dstyk (dual serine/threonine and tyrosine protein kinase [Source:MGI Symbol;Acc:MGI:1925064])

HSP 1 Score: 147.517 bits (371), Expect = 1.076e-35
Identity = 102/340 (30.00%), Postives = 163/340 (47.94%), Query Frame = 2

Query: 1784 KWKMKQAKKCLERCDFKILADEVCKNLLEEFYKKHNEFLAVMDLENFYVQKKIELSDEIRQKL-AEKAPIFAELLMLSLDVKGKYFLQNVEEKEEIGSGSQGTIHRCICDGKEL-AKKKYIVNIDXXXXXXXXXXXXXXXXHP--HLLPFLAVAIIDTEEIDSKEVAIYSPL--MKTDLYNYLCHNKTKLSHRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTID------MRLERLENIPL---ELWNLIEACWNADPEKRP 2758
            +WK K A++ ++      LA  +C          H  F A +         ++E ++++  K+  + AP  A L + S  ++     +  +  +E+G G  G ++ C   G       K +V  D        + + Y    P    L  L  ++ID        VA+   +  +  DLY  L    T L  R+ IA+ + E +++LHS  ++HRD+KL N+LL++ N   + D GFCK  A+   S VGTP+H+APE+     YD  VD+Y+F IL W++  G+ K P+   +F R  + D       R  R E +P+   E W L+EACW+ DP KRP
Sbjct:  561 EWKRKVAQEAIDSLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLKVRKDHAPRLARLSLESRSLQDVLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGGGSSVAVLLIMERLHRDLYTGLKAGLT-LETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFT-GKYDNSVDVYAFGILFWYICSGSIKLPE---AFERCASKDHLWNNVRRGTRPERLPVFDEECWQLMEACWDGDPLKRP 895

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Dstyk (dual serine/threonine and tyrosine protein kinase [Source:MGI Symbol;Acc:MGI:1925064])

HSP 1 Score: 110.923 bits (276), Expect = 2.441e-24
Identity = 90/333 (27.03%), Postives = 142/333 (42.64%), Query Frame = 2

Query: 1784 KWKMKQAKKCLERCDFKILADEVCKNLLEEFYKKHNEFLAVMDLENFYVQKKIELSDEIRQKL-AEKAPIFAELLMLSLDVKGKYFLQNVEEKEEIGSGSQGTIHRCICD---GKELAKKKYIVNIDXXXXXXXXXXXXXXXXHP--HLLPFLAVAIIDTEEIDSKEVAIYSPL--MKTDLYNYLCHNKTKLSHRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTIDMRLERLENIPLELWNLIEACWNADPEKRP 2758
            +WK K A++ ++      LA  +C          H  F A +         ++E ++++  K+  + AP  A L + S  ++     +  +  +E+G G  G ++  +CD   G      K +V  D        + + Y    P    L  L  ++ID        VA+   +  +  DLY  L    T L  R+ IA+ + E +++LHS  ++HRD+KL N+LL++ N   + D GFCK  A+   S VGTP+H+APE+                         TG  P                ERL     E W L+EACW+ DP KRP
Sbjct:  561 EWKRKVAQEAIDSLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLKVRKDHAPRLARLSLESRSLQDVLLHRKPKLGQELGRGQYGVVY--LCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGGGSSVAVLLIMERLHRDLYTGLKAGLT-LETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELF------------------------TGTRP----------------ERLPVFDEECWQLMEACWDGDPLKRP 850

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BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Nek7 (NIMA (never in mitosis gene a)-related expressed kinase 7 [Source:MGI Symbol;Acc:MGI:1890645])

HSP 1 Score: 91.2781 bits (225), Expect = 1.598e-19
Identity = 75/265 (28.30%), Postives = 129/265 (48.68%), Query Frame = 2

Query: 2039 LQNVEEKEEIGSGSQGTIHR--CICDGKELAKKKY----IVNIDXXXXXXXXXXXXXXXXHPHLLPFLAVAIIDTEEIDSKEVAIYSPLMKTDLYNYLCHNKTKLSHRI--SIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYG---FCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTIDMRLERLENIPL-------ELWNLIEACWNADPEKRPKSEYIIE 2779
            L N   +++IG G    ++R  C+ DG  +A KK     +++  +  +  +EI       HP+++ + A  I D E     E+A    L +  +  +    K  +  R      +Q+  AL ++HS  +MHRD+K AN+ +     V L D G   F  S     +S VGTP +++PE I +N Y++K DI+S   LL+ ++    ++P      + + ++  ++E+ +  PL       EL  L+  C N DPEKRP   Y+ +
Sbjct:   31 LANFRIEKKIGRGQFSEVYRASCLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDLSR--MIKHFKKQKRLIPERTVWKYFVQLCSALDHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMA--ALQSPFYGDKMN-LYSLCKKIEQCDYPPLPSDHYSEELRQLVNICINPDPEKRPDIAYVYD 290

[Close]

Query: 2039 LQNVEEKEEIGSGSQGTIHR--CICDGKELAKKKY----IVNIDXXXXXXXXXXXXXXXXHPHLLPFLAVAIIDTEEIDSKEVAIYSPLMKTDLYNYLCHNKTKLSHRI--SIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYG---FCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTIDMRLERLENIPL-------ELWNLIEACWNADPEKRPKSEYIIE 2779
            L N   +++IG G    ++R  C+ DG  +A KK     +++  +  +  +EI       HP+++ + A  I D E     E+A    L +  +  +    K  +  R      +Q+  AL ++HS  +MHRD+K AN+ +     V L D G   F  S     +S VGTP +++PE I +N Y++K DI+S   LL+ ++    ++P      + + ++  ++E+ +  PL       EL  L+  C N DPEKRP   Y+ +
Sbjct:   31 LANFRIEKKIGRGQFSEVYRASCLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDLSR--MIKHFKKQKRLIPERTVWKYFVQLCSALDHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMA--ALQSPFYGDKMN-LYSLCKKIEQCDYPPLPSDHYSEELRQLVNICINPDPEKRPDIAYVYD 290

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BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Fgfr4 (fibroblast growth factor receptor 4 [Source:MGI Symbol;Acc:MGI:95525])

HSP 1 Score: 94.7449 bits (234), Expect = 2.790e-19
Identity = 53/169 (31.36%), Postives = 87/169 (51.48%), Query Frame = 2

Query: 2345 ISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHY----SFVGTPLH-IAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTI---DMRLERLENIPLELWNLIEACWNADPEKRPKSEYIIEKLNHIFETIQ*MYFCL 2827
            +S A Q+A  +QYL S   +HRDL   N+L+ ED+ + +AD+G  +      Y    S    P+  +APE +    Y ++ D++SF ILLW +    G +P        + ++     R+ER  N P EL+ L+  CW+A P +RP  + ++E L+ +   +   Y  L
Sbjct:  587 VSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFT-LGGSPYPGIPVEELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDL 754

[Close]

BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q4VSN3|DUSTY_TETNG (Dual serine/threonine and tyrosine protein kinase OS=Tetraodon nigroviridis OX=99883 GN=dstyk PE=2 SV=1)

HSP 1 Score: 156.377 bits (394), Expect = 1.169e-37
Identity = 105/343 (30.61%), Postives = 159/343 (46.36%), Query Frame = 2

Query: 1781 PKWKMKQAKKCLERCDFKILADEVCKNLLEEFYKKHNEFLAVM-DLENFYVQKKIELSDEIRQKLAEKAPIFAELLMLSLDVKGKYFLQNVEEKEEIGSGSQGTIHRCICD---GKELAKKKYIVNIDXXXXXXXXXXXXXXXXHP--HLLPFLAVAIIDTEEIDSKEVAIYSPL--MKTDLYNYLCHNKTKLSHRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTIDM---------RLERLENIPLELWNLIEACWNADPEKRP 2758
            P+WK K A+  +E      LA  +C       Y  H  F A +  LE  +  +     D   +   + AP  A L + S  ++        +   E+G G  G ++  +CD   G      K +V  D        + + Y+   P    L  L  ++ID        +A+   +  +  DLY  L      L  R+ IA+ + E +++LHS  ++HRD+KL N+LL++ N   + D GFCK  A+   S VGTP+H+APE+     YD  VD+Y+F IL W+L  G+ K P+   +F +  + D          R ERL     E W L+EACWN DP +RP
Sbjct:  555 PEWKRKVAQDAIESLSAAKLARSICSQFRTRLYSSHEAFAASLRQLEERHTGRLERTEDLWLRVRKDHAPRLARLSLESRSLRDVVLHGKPKLGRELGRGQYGVVY--LCDSWGGHNPCALKSVVPPDDKHWNDLALEFHYTRTLPKHERLVDLHGSVIDHTYAGGSSIAVLLIMERLHRDLYTGL-KAGLSLQERLQIALDVVEGIRFLHSQGLLHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFT-GKYDNSVDVYAFGILFWYLCAGSVKLPE---AFEKCSSKDQLWNNVRKGARPERLPCFDEECWQLMEACWNGDPSQRP 890

[Close]

BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q4VSN1|DUSTY_DANRE (Dual serine/threonine and tyrosine protein kinase OS=Danio rerio OX=7955 GN=dstyk PE=2 SV=1)

HSP 1 Score: 151.369 bits (381), Expect = 4.607e-36
Identity = 106/358 (29.61%), Postives = 163/358 (45.53%), Query Frame = 2

Query: 1784 KWKMKQAKKCLERCDFKILADEVCKNLLEEFYKKHNEFLAVM-DLENFYVQKKIELSDEIRQKLAEKAPIFAELLMLSLDVKGKYFLQNVEEKEEIGSGSQGTIHRCICD---GKELAKKKYIVNIDXXXXXXXXXXXXXXXXHP--HLLPFLAVAIIDTEEIDSKEVAIYSPL--MKTDLYNYLCHNKTKLSHRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTIDM---------RLERLENIPLELWNLIEACWNADPEKRPKSEYIIEKLNHIFETI 2806
            +WK K A+  +E      LA  +C          H  F A +  LE  +  +     D   +   + AP  A L + S  ++        +   E+G G  G ++  +CD   G+     K +V  D        + + Y+   P    L  L  ++ID        +A+   +  +  DLY  L      L  R+ IA+ + E +++LHS  ++HRD+KL N+LL++ N   + D GFCK  A+   S VGTP+H+APE+     YD  VD+Y+F IL W+L  G+ K P+   +F +  + D          R ERL     E W L+EACWN DP +RP    +   L  I E +
Sbjct:  525 EWKRKVAQDAIESLSAAKLAKSICSQFRTRLNSSHEAFAASLRQLEEGHTGRLERTEDLWLRVRKDHAPRLARLSLESRSLRDILLHGKPKLGRELGRGQYGVVY--LCDSWAGRHPCALKSVVPPDDKHWNDLALEFHYTRSLPKHERLVNLHGSVIDHSYSGGSSIAVLLIMERLHRDLYTGL-KAGLSLKERLLIALDVVEGIRFLHSQGLLHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFT-GKYDNSVDVYAFGILFWYLCSGSVKLPE---AFEKCASKDQLWTNVKKGCRPERLPVFDEECWQLMEACWNGDPSQRPLLGIVQPGLQSIMERL 875

[Close]

BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|A2CI34|DUSTY_PIMPR (Dual serine/threonine and tyrosine protein kinase OS=Pimephales promelas OX=90988 GN=dstyk PE=2 SV=1)

HSP 1 Score: 150.214 bits (378), Expect = 1.063e-35
Identity = 104/358 (29.05%), Postives = 163/358 (45.53%), Query Frame = 2

Query: 1784 KWKMKQAKKCLERCDFKILADEVCKNLLEEFYKKHNEFLAVM-DLENFYVQKKIELSDEIRQKLAEKAPIFAELLMLSLDVKGKYFLQNVEEKEEIGSGSQGTIHRCICD---GKELAKKKYIVNIDXXXXXXXXXXXXXXXXHP--HLLPFLAVAIIDTEEIDSKEVAIYSPL--MKTDLYNYLCHNKTKLSHRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTIDM---------RLERLENIPLELWNLIEACWNADPEKRPKSEYIIEKLNHIFETI 2806
            +WK K A+  +E      LA  +C          H  F + +  LE  +  +     D   +   + AP  A L + S  ++        +   E+G G  G ++  +CD   G+     K +V  D        + + Y+   P    L  L  ++ID        +A+   +  +  DLY  L      L  R+ IA+ + E +++LH   ++HRD+KL N+LL++ N   + D GFCK  A+   S VGTP+H+APE+     YD  VD+Y+F IL W+L  G+ K P+   +F R  + D          R ERL +   E W L+EACWN DP +RP    +   L  I + +
Sbjct:  538 EWKRKVAQDAIESLSAAKLAKSICSQFRTRLNSSHEAFASSLRQLEEGHTGRLERTEDLWLRVRKDHAPRLARLSLESRSLRDILLHGKPKLGRELGRGQYGVVY--LCDNWAGRHPCALKSVVPPDDKHWNDLALEFHYTRSLPKHERLVNLHGSVIDHSYGGGSSIAVLLIMERLHRDLYTGL-KAGLVLKERLQIALDVVEGIRFLHGQGLLHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFT-GKYDNSVDVYAFGILFWYLCTGSVKLPE---AFERCSSKDQLWTNVKKGSRPERLASFDEECWQLMEACWNGDPSQRPLLGIVQPSLQSIMDRL 888

[Close]

BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q4VSN2|DUSTY_TAKRU (Dual serine/threonine and tyrosine protein kinase OS=Takifugu rubripes OX=31033 GN=dstyk PE=2 SV=1)

HSP 1 Score: 149.828 bits (377), Expect = 1.431e-35
Identity = 103/343 (30.03%), Postives = 158/343 (46.06%), Query Frame = 2

Query: 1781 PKWKMKQAKKCLERCDFKILADEVCKNLLEEFYKKHNEFLAVM-DLENFYVQKKIELSDEIRQKLAEKAPIFAELLMLSLDVKGKYFLQNVEEKEEIGSGSQGTIHRCICD---GKELAKKKYIVNIDXXXXXXXXXXXXXXXXHP--HLLPFLAVAIIDTEEIDSKEVAIYSPL--MKTDLYNYLCHNKTKLSHRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTIDM---------RLERLENIPLELWNLIEACWNADPEKRP 2758
            P+WK K A+  +E      LA  +C          H  F A +  LE  +  +     D   +   + AP  A L + S  ++        +   E+G G  G ++  +CD   G      K +V  D        + + Y+   P    L  L  ++ID        +A+   +  +  DLY  L      L  R+ IA+ + E +++LH+  ++HRD+KL N+LL++ N   + D GFCK  A+   S VGTP+H+APE+     YD  VD+Y+F IL W+L  G+ K P+   +F +  + D          R ERL     E W L+EACWN DP +RP
Sbjct:  555 PEWKRKVAQDAIESLSAAKLARSICSQFRTRLNSSHEAFAASLRQLEERHTGRLERTEDLWLRVRKDHAPRLARLSLESRSLRDVLLHGKPKLGRELGRGQYGVVY--LCDNWGGHYPCALKSVVPPDDKHWNDLALEFHYTRTLPKHERLVDLHGSVIDHTYAGGSSIAVLLIMERLHRDLYTGL-KAGLSLQERLQIALDVVEGIRFLHNQGLLHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFT-GKYDNSVDVYAFGILFWYLCAGSVKLPE---AFEKCSSKDQLWNNVKKGARPERLPCFDEECWQLMEACWNGDPSQRP 890

[Close]

BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q20CR4|DUSTY_MACMU (Dual serine/threonine and tyrosine protein kinase OS=Macaca mulatta OX=9544 GN=DSTYK PE=2 SV=1)

HSP 1 Score: 148.673 bits (374), Expect = 3.394e-35
Identity = 102/340 (30.00%), Postives = 163/340 (47.94%), Query Frame = 2

Query: 1784 KWKMKQAKKCLERCDFKILADEVCKNLLEEFYKKHNEFLAVMDLENFYVQKKIELSDEIRQKL-AEKAPIFAELLMLSLDVKGKYFLQNVEEKEEIGSGSQGTIHRCICDGKEL-AKKKYIVNIDXXXXXXXXXXXXXXXXHP--HLLPFLAVAIIDTEEIDSKEVAIYSPL--MKTDLYNYLCHNKTKLSHRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTID------MRLERLENIPL---ELWNLIEACWNADPEKRP 2758
            +WK K A++ +E      LA  +C          H  F A +         ++E ++++  K+  + AP  A L + S  ++     +  +  +E+G G  G ++ C   G       K +V  D        + + Y    P    L  L  ++ID        +A+   +  +  DLY  L    T L  R+ IA+ + E +++LHS  ++HRD+KL N+LL++ N   + D GFCK  A+   S VGTP+H+APE+     YD  VD+Y+F IL W++  G+ K P+   +F R  + D       R  R E +P+   E W L+EACW+ DP KRP
Sbjct:  541 EWKRKVAQEAIESLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLKVRKDHAPRLARLSLESRSLQDVLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGGGSSIAVLLIMERLHRDLYTGLKAGLT-LETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFT-GKYDNSVDVYAFGILFWYICSGSVKLPE---AFERCASKDHLWNNVRRGARPERLPVFDEECWQLMEACWDGDPLKRP 875

[Close]

BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A267EZE8 (Protein kinase domain-containing protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig017430g1 PE=4 SV=1)

HSP 1 Score: 327.02 bits (837), Expect = 2.477e-93
Identity = 245/870 (28.16%), Postives = 433/870 (49.77%), Query Frame = 2

Query:  332 PAIAVVGQVKSGKSTFVNTLLRKNVVPQAFERCTARITRVTYSMKNFVEIISNEGVILKRKSLNTTTIPK------RFLQLKENVRIDEEEINKQIKAGIHSNFL-KCGIDIIDSPGLSENETLNNLSKNMIKSILPVMIYVIDGRTSVKQTDISDLLELKNAVPNLQIIYFVSKLDT--DDLSETENADPIKLAELKMDIA------FKKLQFNNF--IP------LTFSHWSECNYFHGCSLY---AFMDYTQNSRTPETLFHYNLFCKFEENLHHYLLQNFRNKIEEVCNFLIDFQMEVMTKIINRAQMLSDFNRINFDEINRIKRIEEKLYKKIKSAVKDSKIHLKSCLIKRLKNESDVIVKPISEIIYP-NHLNIPLDGIVSEXXXXXXXXXXXXXNVCQGLENVIKRFVEEELFQKYLEAIQAQIPFRMKNKISVTKSG---KTNYGLCLDRRMAEIYKFNISNNLSNLDGN-NTIMKFMNVIRSSIKGFLMTGLKIEFSQKSVDVKDPKWKMKQAKKCLERCDFKILADEVCKNLLEEFYKKHNEFLAVMDLENFYVQKKIELSDEIRQKLAEKAPIFAELLMLSLDVKGKYFLQN--VEEKEEIGSGSQGTIHRCICDGKELAKKKYIVNIDXXXXXXXXXXX--XXXXXHPHLLPFLAVAIIDTEEIDSKE------VAIYSPLMKTDLYNYLCHNKTKLSHRISIAIQIAEALQYLHSHNIMHRDLKLANILLN-EDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTG-KNPKGATSFHRVMTI------DMRLERLENIPLELWNLIEACWNADPEKRPKSEYIIEKLNHI 2794
            P I VVGQ  SGKSTF+N LL +  V Q+   CTAR+TR+TY+ +  V ++   G     K L  T  P+       F+ LK++ R D   ++  ++ G+ S FL KCG+DI+DSPGL+EN+ L+ L+   I S LP+++YVIDGR  +      D+  ++   P L++ Y V+K+D   +D+   E+   I+  +++ D A       KKLQ       P         S W   NY    ++    +  D    +    + +    F + ++ L  +  + FR+ I   C+ L     + M  ++N+A  +    ++    +  I+ +E + +++ K  V+  +   +      +K++  ++++ +  + Y  N ++  L     E++ + +    I + V    +  +++   ++ F + LE ++A++ F  +  I  T S    K       D + ++IY       +  +  N  TI++   VI               FS+    V+DP+WK  QAK  +++ +   L + +  ++ +   K+H  FL  +      V+    LS+  RQ++ + AP  A +    LDV   Y  +   ++++ ++GSG+QGT++       E+A    +VN++S            S    H +LL    V +++T E D  E        +Y  LM +D++  + + +  L  RI   +Q+A AL++LHS +++HRD+KL N+L++ E N+V L D+G  KST LT  S VGTP+++APE++  ++YD   D+YS  I LW+L EG+G K+PK       V  I      + R +RL  IP +LW+L+E CW+A P  RP ++ + + L++I
Sbjct:   99 PCIVVVGQSNSGKSTFINELLGRKFVDQSSTPCTARVTRITYADRVTVRLLDKHG-----KQLGQTVQPEDGKIDENFIWLKDDSREDANLLSASVELGVPSEFLRKCGLDIVDSPGLNENDALDTLTMRAIDSFLPIILYVIDGRYGITLAAEKDIENIRATAPELELFYLVTKMDVSKEDIPTPESGRTIE--DIEQDRARRVFSRLKKLQCFGAEETPESCSRFFCISSWEMKNYRRRVAIAIKRSGGDQAAGAAVKRSKWVLR-FNEMQQKLADFAAEQFRSLILGACSGLRVLHCQTMDLVMNKANDIRACTQMRRKNLEMIRAMECRNHEQSKKIVEKHREGFEREAESLIKSQGPILLEEVKSMEYSENVIDANLSSNQIEERCVTEIHRFINNRVIVAYQEFLQKGAMQDCFAE-LEDLKARV-FEYERDIEQTPSLAVLKATLADECDLQASDIYSLGFRTVMRQMSLNIQTILRHPGVI---------------FSRP---VQDPEWKRFQAKCHIKKINTGRLVECLVDSMNKWLDKRHFRFLQKIRCSEQLVENSASLSELERQRIVQLAPRLAFMYTRCLDVATGYQFRGYTIDKRAQLGSGAQGTVYAVRDTQGEVAMAAKVVNVESQSLGNISSEVFYSSVLRHCNLLSIEGVRLLETREPDDPEEDAIWTFELYMDLMHSDVWQLMQNRQLTLRKRIWFGLQLARALEFLHSSSLIHRDVKLQNLLVDAELNTVRLTDFGLLKSTGLTGQSLVGTPIYLAPEMVTNSSYDISADVYSLGIALWYLCEGSGSKHPKYVEVMPSVGAILLAGSMNSRPDRLPCIPADLWDLMERCWDAQPRNRPPAKEVADALDYI 940

[Close]

BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A267GJX3 (Protein kinase domain-containing protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig016260g1 PE=4 SV=1)

HSP 1 Score: 320.472 bits (820), Expect = 5.894e-91
Identity = 242/870 (27.82%), Postives = 431/870 (49.54%), Query Frame = 2

Query:  332 PAIAVVGQVKSGKSTFVNTLLRKNVVPQAFERCTARITRVTYSMKNFVEIISNEGVILKRKSLNTTTIPK------RFLQLKENVRIDEEEINKQIKAGIHSNFL-KCGIDIIDSPGLSENETLNNLSKNMIKSILPVMIYVIDGRTSVKQTDISDLLELKNAVPNLQIIYFVSKLDT--DDLSETENADPIKLAELKMDIA------FKKLQFNNF--IP------LTFSHWSECNYFHGCSLY---AFMDYTQNSRTPETLFHYNLFCKFEENLHHYLLQNFRNKIEEVCNFLIDFQMEVMTKIINRAQMLSDFNRINFDEINRIKRIEEKLYKKIKSAVKDSKIHLKSCLIKRLKNESDVIVKPISEIIYP-NHLNIPLDGIVSEXXXXXXXXXXXXXNVCQGLENVIKRFVEEELFQKYLEAIQAQIPFRMKNKISVTKSG---KTNYGLCLDRRMAEIYKFNISNNLSNLDGN-NTIMKFMNVIRSSIKGFLMTGLKIEFSQKSVDVKDPKWKMKQAKKCLERCDFKILADEVCKNLLEEFYKKHNEFLAVMDLENFYVQKKIELSDEIRQKLAEKAPIFAELLMLSLDVKGKYFLQN--VEEKEEIGSGSQGTIHRCICDGKELAKKKYIVNIDXXXXXXXXXXX--XXXXXHPHLLPFLAVAIIDTEEIDSKE------VAIYSPLMKTDLYNYLCHNKTKLSHRISIAIQIAEALQYLHSHNIMHRDLKLANILLN-EDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTG-KNPKGATSFHRVMTI------DMRLERLENIPLELWNLIEACWNADPEKRPKSEYIIEKLNHI 2794
            P I VVGQ  SGKSTF+N LL +  V Q+   CTAR+TR+TY+ +  V ++   G     K L  T  P+        + LK++ R D   ++  ++ G+ S FL KCG+DI+DSPGL+EN+ L+ L+   I S LP+++YVIDGR  +      D+  ++   P L++ Y V+K+D   +D+   E+   I+  +++ D A       KKLQ       P         S W   NY    ++    +  D    +    + +    F + ++ L  +  + FR+ I   C+ L     + M  ++N+A  +    ++    +  I+ +E + +++ K  V+  +   +      +K++  ++++ +  + Y  N ++  L     E++ + +    I + V    +  +++   ++ F + LE ++A++ F  +  I  T S    K       D + ++IY       +  +  N  TI++   VI               FS+    V+DP+WK  QAK  +++ +   L + +  ++ +   K+H  FL  +      V+    LS+  RQ++ + AP  A +    L+V   Y  +   ++++ ++GSG+QGT++       E+A    +VN++S            S    H +LL    V +++T E D  E        +Y  LM +D++  + + +  L  RI   +Q+A AL++LHS +++HRD+KL N+L++ E  +V L D+G  KST LT  S VGTP+++APE++  ++YD   D+YS  I LW+L EG+G K+PK       V  I      + R +RL  IP +LW+L+E CW+A P  RP ++ + + L++I
Sbjct:   99 PCIVVVGQSNSGKSTFINELLGRKFVDQSSTPCTARVTRITYADRVTVRLLDKHG-----KQLGQTVQPEDGKIDENLIWLKDDSREDANLLSASVELGVPSEFLRKCGLDIVDSPGLNENDALDTLTMRAIDSFLPIILYVIDGRYGITLAAEKDIENIRATAPELELFYLVTKMDVSKEDIPTPESGRTIE--DIEQDRARRVFSRLKKLQCFGAEETPESCSRFFCISSWEMKNYRRRVAIAIKRSGGDQAAGAAVKRSKWVLR-FNEMQQKLADFAAEQFRSLILGACSGLRVLHCQTMDLVMNKANDIRACTQMRRKNLEMIRAMECRNHEQSKKIVEKHREGFEREAESLIKSQGPILLEEVKSMEYSENVIDANLSSNQIEERCVTEIHRFINNRVIVAYQEFLQKGAMQDCFAE-LEDLKARV-FEYERDIEQTPSLAVLKATLADECDLQASDIYSLGFRTVMRQMSLNIRTILRHPGVI---------------FSRP---VQDPEWKRFQAKCHIKKINTGRLVECLVDSMNKWLDKRHFRFLQKIRCSEQLVENSASLSELERQRIVQLAPRLAFMYTRCLNVATGYQFRGYTIDKRAQLGSGAQGTVYAVRDTQGEVAMAAKVVNVESQSLGNISSEVFYSSVLRHCNLLSIEGVRLLETREPDDPEEDAIWTFELYMDLMHSDVWQLMQNRQLTLRKRIWFGLQLARALEFLHSSSLIHRDVKLQNLLVDAELTTVRLTDFGLLKSTGLTGQSLVGTPIYLAPEMVTNSSYDISADVYSLGIALWYLCEGSGSKHPKYVEVMPSVGAILLAGSMNSRPDRLPCIPADLWDLMERCWDAQPRNRPPAKEVADALDYI 940

[Close]

BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A2B4SY00 (Dual serine/threonine and tyrosine protein kinase OS=Stylophora pistillata OX=50429 GN=Dstyk PE=4 SV=1)

HSP 1 Score: 310.842 bits (795), Expect = 2.554e-87
Identity = 259/973 (26.62%), Postives = 456/973 (46.87%), Query Frame = 2

Query:   77 NLTRVIKDYRQNRERLVKIQSSTKKTFDQITEILKSDTGSLL---------------DCVDSNNLNNIAADLGNFEDSDILAD------EQFYLKSVFEKQVEIGNPAIAVVGQVKSGKSTFVNTLLRKNVVPQAFERCTARITRVTYSMKNFVEIISNEGVIL---KRKSLNTTTIPKRFLQLKENVRIDEEEINKQIKAGIHSNFLKCGIDIIDSPGLSENETLNNLSKNMIKSILPVMIYVIDGRTSVKQTDISDLLELKNAVPNLQIIYFVSKLDTDDLSETENAD----------------PIKLAELKMDIAFKKLQFNNFIPLTFSHWSECNYFHGCSLYAFMDY-TQNSRTPETLF-----HYNLFCKFEENLHHYLLQNFRNKIEEVCNFLIDFQMEVMTKIINRAQMLSDFNRINFDEINRIKRIEEKLYKKIKSAVKDSKI--HLKSCLIKRLKNESDVIVKPISEIIYP-NHLNIPLDGIVSEXXXXXXXXXXXXXNVCQGLENVIKR-----FVEEELFQKYL----EAIQAQIPFRMKNKISVTKSGKTNYGLCLDRRMAEIYKFNISNNLSNLDGNNTIMKFMNVIRSSIKGFLMTGLKIEFSQKSVDVKDPKWKMKQAKKCLERCDFKILADEVCKNLLEEFYKKHNEFLAVMDLENFYVQKKIELSDEIRQKLAEKAPIFAELLMLSLDVKGKYFLQNVEEKEEIGSGSQGTIHRC----ICDGKE-LAKKKYIVNIDXXXXXXXXXXXXXXXXHPHLLPFLAVAIIDTEEIDSKEVAIYSPLMKTDLYNYLCHNKTKLSHRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTIDM-------RLERLENIPLELWNLIEACWNADPEKRPKSEYIIEKL 2785
            +L  V +D+++++  L K+   T K FD+I + L S   + +               + V    L    AD+ + E  + LA+      E+  +  +F+++     PA+  VGQ   GKS+ +N LL    +P + +  TARI RV ++ K +  ++   G  L   K    +   IP++ ++LK   R D  ++   +++GI+ +FLKCG+ IIDSPG +ENE L+NL K  +++ L  +IYV+DG     + D   L E+ ++  +L I + VSKL+ +D +E+ + D                 +K+ E K    +++L  N   P       E   FHG S +    Y     + P+  F     +   F +F+ +L  +  ++ R ++E VC  LI      +   I +A +L          +    R E++++  I   ++D K    ++  L   ++     I+K   +  Y    L IP  G V EK  +  CQ  I   V   L+  IK+     F   +LF  +L    E IQ +I            S   +  L L   +   Y+  I+ +  +      IMK       +I+  + T +K    +  V V   +WK+K A + L++ D  ++A E+  +L + F   H EF + +        +   + D  R+ +   AP  A L ML+  V  ++        + IGSG+QG++  C      +G+  + K   +   + ++++  E++ + + +H ++LP L   ++++       V + S  M+ DL++ L  +   +  R+ IA+ +A+ALQYLH  +++HRD+K+ N+LL+E+N+  L D G CK   L   S VGTP+++APE+I K  YD  +D+Y+F ++LW + EG G  P+        + + M         E+L+  P   W L++ CW  DPE RP  + ++  L
Sbjct:    2 SLQEVFEDFKKSKAVLQKVHLDTVKYFDEIVQKLSSKGTADIAEELRYKTLPVQASPEEVQVMALTVAMADV-HLEFDNTLAEMLYTAKEKKEVTDLFDQE-----PALIFVGQTNCGKSSIINELLGCKALPTSDQPSTARIVRVCHAEKPYCRLVDTNGKTLEEIKMTGKDGNRIPRKKIELKPKDRNDPTKVGAIVESGINIDFLKCGVTIIDSPGRNENEALDNLVKKQLENPLAFVIYVVDGHDLFTKQDREVLNEMTSSGNDLSIFFVVSKLEPEDRTESSDEDDEPGGHAASTKARKKGELKVQERKKTRVYERLVKNGHFPSQLC-MDENERFHGLSAWRIQQYLASKKKNPKASFDEYTDYVEAFKRFQNSLKKFAEESLRARVESVCKTLIRVLSRCLDFFIQKANVLKKGKTQILKTLGTFLREEQQVHDNIIRDLEDEKRAEDIRDLLSDAMEGAKGDILKEAGDFEYVLAELTIPSSGHVKEKAAVAHCQDQIRCMVVNKLQGEIKQRLTMMFRSRDLFVVHLKDGMEQIQGEI---------AADSDIPSAALALGNSLLSSYETQITFSQRHGAAVRFIMKVSEWFYKAIRNPIDTVVKTITGE--VQVGSKEWKVKVASEALKKVDPSLMAKEIVSSLKQHFCDCHQEFTSEIGKVQDLFDRGETIKDMQRETILGFAPNLALLEMLAYGVMDRFKFGFPAAGDLIGSGAQGSVFACNNIKTPEGRPCVVKVVKVATEEVLKDLTLELHNTRALQHSNILPVLCT-VVESNPTRGLSVQLVSERMRCDLHDGL-KDIPSMRKRLEIALDVAKALQYLHGEDLIHRDVKMQNVLLDEENNAKLTDLGLCKPEGLISNSLVGTPINMAPEMI-KQQYDKSIDVYAFGMMLWRVCEGQGNQPQNINRHFLPLVMLMMNAVDNKTPEKLDVFPEHCWQLMQKCWTQDPEARPSFDSVVRDL 953

[Close]

BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A3M6TL50 (Protein kinase domain-containing protein OS=Pocillopora damicornis OX=46731 GN=pdam_00001199 PE=4 SV=1)

HSP 1 Score: 300.056 bits (767), Expect = 2.056e-83
Identity = 261/972 (26.85%), Postives = 450/972 (46.30%), Query Frame = 2

Query:   80 LTRVIKDYRQNRERLVKIQSSTKKTFDQITEILKSDTGSL----------------LDCVDSNNLNNIAADLG---NFEDSDIL--ADEQFYLKSVFEKQVEIGNPAIAVVGQVKSGKSTFVNTLLRKNVVPQAFERCTARITRVTYSMKNFVEIISNEGVIL---KRKSLNTTTIPKRFLQLKENVRIDEEEINKQIKAGIHSNFLKCGIDIIDSPGLSENETLNNLSKNMIKSILPVMIYVIDGRTSVKQTDISDLLELKNAVPNLQIIYFVSKLDTDDLSETENAD--------PIK--------LAELKMDIAFKKLQFNNFIPLTFSHWSECNYFHGCSLYAFMDY-TQNSRTPET-----LFHYNLFCKFEENLHHYLLQNFRNKIEEVCNFLIDFQMEVMTKIINRAQMLSDFNRINFDEINRIKRIEEKLYKKIKSAVKDSK--IHLKSCLIKRLKNESDVIVKPISEIIYP-NHLNIPLDGIVSEXXXXXXXXXXXXXNVCQGLENVIKR-----FVEEELFQKYLEAIQAQIPFRMKNKISVTKSGKTNYGLCLDRRMAEIYKFNISNNLSNLDGNNTIMK----FMNVIRSSIKGFLMTGLKIEFSQKSVDVKDPKWKMKQAKKCLERCDFKILADEVCKNLLEEFYKKHNEFLAVMDLENFYVQKKIELSDEIRQKLAEKAPIFAELLMLSLDVKGKYFLQNVEEKEEIGSGSQGTIHRC----ICDGKE-LAKKKYIVNIDXXXXXXXXXXXXXXXXHPHLLPFLAVAIIDTEEIDSKEVAIYSPLMKTDLYNYLCHNKTKLSHRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTIDM-------RLERLENIPLELWNLIEACWNADPEKRPKSEYIIEKL 2785
            L  V +D+++++  L K+   T K FD+I   L SD G+                  D V         AD+    ++  +++L  A E+  +  +F+++     PA+  VGQ   GKS+ +N LL    +P + +  TARI RV ++ + +  ++   G  L   K        IP++ ++LK   R D  ++   ++ G++  FLKCG+ IIDSPG +EN+ L+NL K  +K+ L  +IYV+DG     + D   L E+ ++  +L I + VSKL+ +D +E+ + D        P+K        +   K    +++L  N   P   S  ++   FHG S +    Y     R PE        +   F +F+ +L  +  ++ R ++  VC  L+      +   I +A +L    +     +  + R E+++++ I   ++D K  + ++  L   +    + I+K   +  Y      IP DG V EKQ +  CQ  I   V + L+  IK+     F   +LF  +L+    QI   +     +  +      L L + +   Y+  I+    N      I +    F N IR+ IK  + T          V V   KWK   A   L + +   +A ++  +L E F   H EF   +        +   + D  R+ L   AP  A L ML+  V  ++      + E IG+G+QG +  C      +G+  + K   + + + ++++  E++ + +  HP++LP +   ++++       V + S  M+ DL++ L      L  R+ IA+ +A+ALQYLH   ++HRD+K+ N+LL+E N+  L D G CK   L   S VGTP+++APE ++K  YD  +D+Y+F +LLW + EG G  P+        + + M         ERL+  P + W L+  CWN DPE RP  + ++  L
Sbjct:    3 LQDVFEDFKKSKAVLKKVHHDTVKYFDEIVRKL-SDKGTAEIVEELRYSTSPVQASPDEVRVMAQTVAMADVHLEFDYALAELLYTAKEKKEVTDLFDQE-----PALIFVGQTNCGKSSIINELLGCKALPTSDQPSTARIVRVCHAEEPYCRLVDTHGKTLEEIKMMGKEGNRIPRKKIELKPKDRDDPSKVGAIVETGLNIEFLKCGVTIIDSPGRNENKALDNLVKEQLKNPLAFVIYVVDGHDLFTKQDREVLNEMTSSGTDLSIFFVVSKLEPEDRTESSDEDDEPRGHAAPVKARKKRELEVQNRKKTRVYERLVKNGHFPSQLS-MNQNERFHGLSAWRIQQYHALKKRNPEASSEEFTDYTQAFERFQNSLKEFAEESLRARVACVCRTLVRVLSRCLDFFIQKANVLKRGKKQILKTLETLLREEQQVHENIIRDLEDEKRAMEIQELLSDAINGAREDILKGAGDFEYVLTEFTIPSDGHVKEKQAVAYCQDQIQGMVVKKLQGEIKQKLTMMFRSRDLFLVHLKDGMEQIQGEIARDNDIPSA-----ALALGKSLLSSYEAQITFPQRNGAALRFIKQLSEWFYNAIRNPIKTIIKT------ISGEVQVGSKKWKTDVASNALAKVNPSDMAQKIVTSLKELFRDCHEEFTGEIRKVQDLFDRGETIKDMQRETLLGFAPNLALLEMLAYGVMDRFKFGLPAKGELIGTGAQGNVFACDNIKTPEGRPCVVKVVGVASEEVLKDLTLELHNTRALHHPNILPVICT-VVESNPNCGLSVQLVSERMRCDLHDGLV-GIPSLRKRLEIALDVAKALQYLHGEELIHRDVKMQNVLLDEKNNAKLTDLGLCKPEGLICNSLVGTPINMAPE-MLKQQYDKSIDVYAFGMLLWRVCEGQGNQPQNINRHFLPLVMLMMNAVDNKTPERLDVFPEQCWQLMVRCWNQDPEARPSFDSVVRDL 953

[Close]

BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A267GPS2 (Protein kinase domain-containing protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig024597g1 PE=4 SV=1)

HSP 1 Score: 295.049 bits (754), Expect = 1.089e-82
Identity = 229/845 (27.10%), Postives = 415/845 (49.11%), Query Frame = 2

Query:  407 VPQAFERCTARITRVTYSMKNFVEIISNEGVILKRKSLNTTTIPK------RFLQLKENVRIDEEEINKQIKAGIHSNFL-KCGIDIIDSPGLSENETLNNLSKNMIKSILPVMIYVIDGRTSVKQTDISDLLELKNAVPNLQIIYFVSKLDT--DDLSETENADPIKLAELKMDIA------FKKLQFNNF--IP------LTFSHWSECNYFHGCSLY---AFMDYTQNSRTPETLFHYNLFCKFEENLHHYLLQNFRNKIEEVCNFLIDFQMEVMTKIINRAQMLSDFNRINFDEINRIKRIEEKLYKKIKSAVKDSKIHLKSCLIKRLKNESDVIVKPISEIIYP-NHLNIPLDGIVSEXXXXXXXXXXXXXNVCQGLENVIKRFVEEELFQKYLEAIQAQIPFRMKNKISVTKSG---KTNYGLCLDRRMAEIYKFNISNNLSNLDGN-NTIMKFMNVIRSSIKGFLMTGLKIEFSQKSVDVKDPKWKMKQAKKCLERCDFKILADEVCKNLLEEFYKKHNEFLAVMDLENFYVQKKIELSDEIRQKLAEKAPIFAELLMLSLDVKGKYFLQN--VEEKEEIGSGSQGTIHRCICDGKELAKKKYIVNIDXXXXXXXXXXX--XXXXXHPHLLPFLAVAIIDTEEIDSKE------VAIYSPLMKTDLYNYLCHNKTKLSHRISIAIQIAEALQYLHSHNIMHRDLKLANILLN-EDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTG-KNPKGATSFHRVMTI------DMRLERLENIPLELWNLIEACWNADPEKRPKSEYIIEKLNHI 2794
            V Q+   CTAR+TR+TY+ +  V ++   G     K L  T  P+        + LK++ R D   ++  ++ G+ S FL KCG+DI+DSPGL+EN+ L+ L+   I S LP+++YVIDGR  +      D+  ++   P L++ Y V+K+D   +D+   E+   I+  +++ D A       KKLQ       P         S W   NY    ++    +  D    +    + +    F + ++ L  +  + FR+ I   C+ L     + M  ++N+A  +    ++    +  I+ +E + +++ K  V+  +   +      +K++  ++++ +  + Y  N ++  L     E++ + +    I + V    +  +++   ++ F + LE ++A++ F  +  I  T S    K       D + ++IY       +  +  N  TI++   VI               FS+    V+DP+WK  QAK  +++ +   L + +  ++ +   K+H  FL  +      V+    LS+  RQ++ + AP  A +    LDV   Y  +   ++++ ++GSG+QGT++       E+A    +VN++S            S    H +LL    V +++T E D  E        +Y  LM +D++  + + +  L  RI   +Q+A AL++LHS +++HRD+KL N+L++ E N+V L D+G  KST LT  S VGTP+++APE++  ++YD   D+YS  I LW+L EG+G K+PK       V  I      + R +RL  IP +LW+L+E CW+A P  RP ++ + + L++I
Sbjct:    2 VDQSSTPCTARVTRITYADRVTVRLLDKHG-----KQLGQTVQPEDGKIDENLIWLKDDSREDANLLSASVELGVPSEFLRKCGLDIVDSPGLNENDALDTLTMRAIDSFLPIILYVIDGRYGITLAAEKDIENIRATAPELELFYLVTKMDVSKEDIPTPESGRTIE--DIEQDRARRVFSRLKKLQCFGAEETPESCSRFFCISSWEMKNYRRRVAIAIKRSGGDQAAGAAVKRSKWVLR-FNEMQQKLADFAAEQFRSLILGACSGLRVLHCQTMDLVMNKANDIRACTQMRRKNLEMIRAMECRNHEQSKKIVEKHREGFEREAESLIKSQGPILLEEVKSMEYSENVIDANLSSNQIEERCVTEIHRFINNRVIVAYQEFLQKGAMQDCFAE-LEDLKARV-FEYERDIEQTPSLAVLKATLADECDLQASDIYSLGFRTVMRQMSLNIRTILRHPGVI---------------FSRP---VQDPEWKRFQAKCHIKKINTGRLVECLVDSMNKWLDKRHFRFLQKIRCSEQLVENSASLSELERQRIVQLAPRLAFMYTRCLDVATGYQFRGYTIDKRAQLGSGAQGTVYAVRDTQGEVAMAAKVVNVESQSLGNISSEVFYSSVLRHCNLLSIEGVRLLETREPDDPEEDAIWTFELYMDLMHSDVWQLMQNRQLTLRKRIWFGLQLARALEFLHSSSLIHRDVKLQNLLVDAELNTVRLTDFGLLKSTGLTGQSLVGTPIYLAPEMVTNSSYDISADVYSLGIALWYLCEGSGSKHPKYVEVMPSVGAILLAGSMNSRPDRLPCIPADLWDLMERCWDAQPRNRPPAKEVADALDYI 818

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: dstyk (dual serine/threonine and tyrosine protein kinase [Source:NCBI gene;Acc:402922])

HSP 1 Score: 114.005 bits (284), Expect = 2.674e-25
Identity = 89/332 (26.81%), Postives = 137/332 (41.27%), Query Frame = 2

Query: 1781 PKWKMKQAKKCLERCDFKILADEVCKNLLEEFYKKHNEFLAVM-DLENFYVQKKIELSDEIRQKLAEKAPIFAELLMLSLDVKGKYFLQNVEEKEEIGSGSQGTIHRCICDGKE-LAKKKYIVNIDXXXXXXXXXXXXXXXXHP--HLLPFLAVAIIDTEEIDSKEVAIYSPL--MKTDLYNYLCHNKTKLSHRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTIDMRLERLENIPLELWNLIEACWNADPEKRP 2758
            P+WK K A+  +E      LA  +C          H+ F A +  LE  +  +     D   +   + AP  A L + S  ++        +   E+G G  G ++ C   G++     K +V  D        + + Y+   P    L  L  ++ID        +A+   +  +  DLY  L      L  R+ IA+ + E +++LH   ++HRD+KL N+LL++ N   + D GFCK  A+   S VGTP+H+APE+                         TG  P                ERL     E W L+EACWN DP +RP
Sbjct:  544 PEWKRKVAQDAIESLSAAKLAKSICSQFRTRLNSSHDAFAASLRQLEEGHTGRLERTEDLWLRVRKDHAPRLARLSLESRSLRDVLLYGKPKLGRELGRGQYGVVYLCDKWGEQNPCALKSVVPPDDKHWNDLALEFHYTRSLPKHERLVNLHGSVIDHTYGGGSSIAVLLIMERLHRDLYTGL-KAGLSLKERLQIALDVVEGIRFLHGQGLLHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELF------------------------TGSRP----------------ERLPTFDEECWQLMEACWNGDPLQRP 834

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: stk25b (serine/threonine-protein kinase 25-like [Source:NCBI gene;Acc:103039280])

HSP 1 Score: 91.2781 bits (225), Expect = 5.368e-19
Identity = 60/162 (37.04%), Postives = 88/162 (54.32%), Query Frame = 2

Query: 2348 SIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKS---TALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFH--RVMTIDMR-----LERLENIPLELWNLIEACWNADPEKRPKSEYIIEKLNHIFET 2803
            +I  +I + L+YLHS   +HRD+K AN+LL+E   V LAD+G       T +   +FVGTP  +APE+I ++ YD+K DI+S  I    L++G   N    +  H  RV+ +  +     LE   + P +    +EAC N DP  RP ++   E L H F T
Sbjct:  123 TILREILKGLEYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPN----SDLHPMRVLFLIPKNPPPTLEGSYSKPFK--EFVEACLNKDPRFRPTAK---ELLKHKFIT 275

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: stk25b (serine/threonine-protein kinase 25-like [Source:NCBI gene;Acc:103039280])

HSP 1 Score: 90.8929 bits (224), Expect = 7.798e-19
Identity = 60/162 (37.04%), Postives = 88/162 (54.32%), Query Frame = 2

Query: 2348 SIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKS---TALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFH--RVMTIDMR-----LERLENIPLELWNLIEACWNADPEKRPKSEYIIEKLNHIFET 2803
            +I  +I + L+YLHS   +HRD+K AN+LL+E   V LAD+G       T +   +FVGTP  +APE+I ++ YD+K DI+S  I    L++G   N    +  H  RV+ +  +     LE   + P +    +EAC N DP  RP ++   E L H F T
Sbjct:  119 TILREILKGLEYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPN----SDLHPMRVLFLIPKNPPPTLEGSYSKPFK--EFVEACLNKDPRFRPTAK---ELLKHKFIT 271

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: nek7 (NIMA related kinase 7 [Source:NCBI gene;Acc:103046491])

HSP 1 Score: 88.1965 bits (217), Expect = 1.114e-18
Identity = 50/156 (32.05%), Postives = 85/156 (54.49%), Query Frame = 2

Query: 2357 IQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYG---FCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTIDMRLERLENIPL-------ELWNLIEACWNADPEKRPKSEYIIEKLNHI 2794
            +Q+  AL+++HS  +MHRD+K AN+ +     V L D G   F  S     +S VGTP +++PE I +N Y++K DI+S   LL+ ++    ++P      + + ++  ++E+ +  PL       EL  L++ C N DPE+RP   Y+     H+
Sbjct:  128 VQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMA--ALQSPFYGDKMN-LYSLCKKIEQCDYPPLPSDHYSEELRKLVDMCINPDPERRPDIAYVYNIAKHM 280

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: nek7 (NIMA related kinase 7 [Source:NCBI gene;Acc:103046491])

HSP 1 Score: 88.5817 bits (218), Expect = 1.242e-18
Identity = 50/156 (32.05%), Postives = 85/156 (54.49%), Query Frame = 2

Query: 2357 IQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYG---FCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTIDMRLERLENIPL-------ELWNLIEACWNADPEKRPKSEYIIEKLNHI 2794
            +Q+  AL+++HS  +MHRD+K AN+ +     V L D G   F  S     +S VGTP +++PE I +N Y++K DI+S   LL+ ++    ++P      + + ++  ++E+ +  PL       EL  L++ C N DPE+RP   Y+     H+
Sbjct:  149 VQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMA--ALQSPFYGDKMN-LYSLCKKIEQCDYPPLPSDHYSEELRKLVDMCINPDPERRPDIAYVYNIAKHM 301

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BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: stk39 (serine threonine kinase 39 [Source:ZFIN;Acc:ZDB-GENE-140106-194])

HSP 1 Score: 88.5817 bits (218), Expect = 4.651e-19
Identity = 61/194 (31.44%), Postives = 86/194 (44.33%), Query Frame = 2

Query: 2348 SIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTAL--------THYSFVGTPLHIAPEIIMK-NNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTIDMRLERLENIPLEL-----------------WNLIEACWNADPEKRPKS---------------EYIIEKLNHIFETI 2806
            SI  ++ E L YLH +  +HRD+K  NILL ED ++ +AD+G     A            +FVGTP  +APE++ +   YD+K DI+SF I    L+        GA  +H+   + + +  L+N P  L                   LI  C   DP KRP +               EY+ EKL H   TI
Sbjct:    9 SILKEVLEGLDYLHRNGQIHRDVKAGNILLGEDGTIQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAMELA-------SGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMVKKYGKSFRKLISQCLQKDPAKRPTAAELLKSKFFQKAKNKEYLAEKLLHKAPTI 195

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BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008193.1 (pep scaffold:Pmarinus_7.0:GL476850:102262:127365:-1 gene:ENSPMAG00000007385.1 transcript:ENSPMAT00000008193.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 86.6557 bits (213), Expect = 2.431e-18
Identity = 73/260 (28.08%), Postives = 114/260 (43.85%), Query Frame = 2

Query: 2039 LQNVEEKEEIGSGSQGTIHRCICDGKELAKKKYIVNIDXXXXXXXXXXXXXXXXHPHLLPFLAVAIIDTEEIDSKEVAIYSPLM----KTDLYNYLCHNKTKLSHRISIAI------QIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKST--ALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEG--TGKNPKGATSFHRVMTIDMRLERLENIPLELWNLIEACWNADPEKRPKSEYII 2776
             + + E + +GSG+QG +      G+ +A KK        E+   +I + +   HP+++ F  V               Y  +M    +  LY  L     +   RIS  +       IA  + YLH H I+HRDLK  N+L+  D+ V ++D+G  K      T  SF GT   +APE+I       KVDI+SF ++LW L  G    ++   +     V +  + L    + P     L+  CWN+ P  RP    I+
Sbjct:   11 FEEISELQWLGSGAQGAVFLGKFRGEHVAVKKV------REQKETDIKHLHKLRHPNIITFKGVCT---------HAPCYCIIMEYCAQGQLYEVL-----RAGRRISPELLVGWTRGIARGMSYLHLHKIIHRDLKSPNVLITHDDEVKISDFGTSKEMREKSTRMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYRDVDSSAIIWGVGSNSLHLPIPASCPEGFKILLTQCWNSKPRNRPSFRQIL 250

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BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: STK36 (serine/threonine kinase 36 [Source:HGNC Symbol;Acc:HGNC:17209])

HSP 1 Score: 89.3521 bits (220), Expect = 2.781e-18
Identity = 58/191 (30.37%), Postives = 105/191 (54.97%), Query Frame = 2

Query: 2201 HPHLLPFLAVAIIDTEEIDSKEVAIYSPLMKTDLYNYLCHNKTKLSHRI-SIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTA---LTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTIDMR--LERLENIPLELWNLIEACWNADPEKR 2755
            HP++     V ++D+ E D KEV + +   + +L+  L  +      ++  IA Q+  AL YLHSH I+HRD+K  NILL +   V L D+GF ++ +   L   S  GTPL+++PE++ +  YD+  D++S   +L+ L  GT   P    S  +++++ ++  ++  +N+  E  N ++     +P+ R
Sbjct:   60 HPNI-----VQMLDSFETD-KEVVVVTDYAEGELFQILEDDGNLPEEQVREIACQLVSALYYLHSHRILHRDMKPQNILLGKGGVVKLCDFGFARAMSINTLVLTSIKGTPLYMSPELVEEKPYDHTADLWSMGCILYELFVGT--PPFYTNSIFQLVSLIIKDPVKWPKNMSSEFRNFLQGLLTKEPKLR 242

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BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002088.1 (pep scaffold:Pmarinus_7.0:GL478600:446:35095:-1 gene:ENSPMAG00000001892.1 transcript:ENSPMAT00000002088.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 82.8037 bits (203), Expect = 1.445e-17
Identity = 53/161 (32.92%), Postives = 76/161 (47.20%), Query Frame = 2

Query: 2363 IAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKS--TALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEG--TGKNPKGATSFHRVMTIDMRLERLENIPLELWNLIEACWNADPEKRPKSEYIIEKLN----HIFETIQ*MYF 2821
            IA  + YLH H I+HRDLK  N+L+  D+ V ++D+G  K      T  SF GT   +APE+I       KVDI+SF ++LW L  G    ++   +     V +  + L    + P     L+  CW   P  RP    I+  L+     +  T Q  YF
Sbjct:   44 IASGMNYLHLHKIIHRDLKSPNVLITHDDLVKISDFGTSKELMDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYRDVDSSAIIWGVGSNSLHLPVPTSCPDGFKILLTQCWTGKPRNRPSFRQILLHLDIASADLLSTPQETYF 204

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BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: PRKCD (protein kinase C delta [Source:HGNC Symbol;Acc:HGNC:9399])

HSP 1 Score: 82.0333 bits (201), Expect = 2.307e-17
Identity = 39/86 (45.35%), Postives = 56/86 (65.12%), Query Frame = 2

Query: 2354 AIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHY---SFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLW 2602
            A +I   LQ+LH   I++RDLKL NILL++D  V +AD+G CK   +      +F GTP +IAPEI++   Y+  VD +SF +LL+
Sbjct:   94 AAEIVSGLQFLHDQGIIYRDLKLDNILLDKDGHVKIADFGMCKENIVGDVRAGTFCGTPDYIAPEIVIGQKYNCSVDWWSFGVLLY 179

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BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: TPK2 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase; relocalizes to the cytosol in response to hypoxia [Source:SGD;Acc:S000006124])

HSP 1 Score: 90.5077 bits (223), Expect = 9.467e-20
Identity = 62/216 (28.70%), Postives = 109/216 (50.46%), Query Frame = 2

Query: 1994 AELLMLSLDVKGKYFLQNVEEKEEIGSGSQGTIH--RCICDGKELA----KKKYIVNIDXXXXXXXXXXXXXXXXHPHLLPFLAVAIIDTEEIDSKEVAIYSPLMKTDLYNYLCHNKTKLSHRIS--IAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEG 2617
            ++L   SL  KGKY L + +    +G+GS G +H  R + +G+  A    KK+ +V +  +E   +E       EHP L+             D++ + +    ++      L     +  + ++   A ++  AL+YLH+HNI++RDLK  NILL+ +  + + D+GF K      ++  GTP +IAPE+I    Y+  VD +S  +L++ +  G
Sbjct:   52 SQLPQKSLVSKGKYTLHDFQIMRTLGTGSFGRVHLVRSVHNGRYYAIKVLKKQQVVKMKQVEHTNDERRMLKLVEHPFLIRMWGTFQ------DARNIFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVILALEYLHAHNIIYRDLKPENILLDRNGHIKITDFGFAKEVQTVTWTLCGTPDYIAPEVITTKPYNKSVDWWSLGVLIYEMLAG 261

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: TPK3 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication [Source:SGD;Acc:S000001649])

HSP 1 Score: 86.2705 bits (212), Expect = 3.027e-18
Identity = 65/238 (27.31%), Postives = 116/238 (48.74%), Query Frame = 2

Query: 1940 IELSDEIRQKLAEKAP----IFAELLMLSLDVKGKYFLQNVEEKEEIGSGSQGTIH--RCICDGKELA----KKKYIVNIDXXXXXXXXXXXXXXXXHPHLLPFLAVAIIDTEEIDSKEVAIYSPLMKTDLYNYLCHNKTKLSHRIS--IAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEG 2617
            +E++     KL E+A     +  + ++   D  GKY L + +    +G+GS G +H  R   +G+  A    KK  IV +  +E   +E        HP ++             DS++V +    ++      L     +  + ++   A ++  AL+YLHS +I++RDLK  NILL+++  + + D+GF K      Y+  GTP +IAPE++    Y+  VD +SF +L++ +  G
Sbjct:   48 VEINGRNSGKLKEEASAGICLVKKPMLQYRDTSGKYSLSDFQILRTLGTGSFGRVHLIRSNHNGRFYALKTLKKHTIVKLKQVEHTNDERRMLSIVSHPFIIRMWGTFQ------DSQQVFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTPDYIAPEVVSTKPYNKSVDWWSFGVLIYEMLAG 279

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: TPK1 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; phosphorylates and inhibits Whi3p to promote G1/S phase passage; partially redundant with Tpk2p and Tpk3p; phosphorylates pre-Tom40p, which impairs its import into mitochondria under non-respiratory conditions; TPK1 has a paralog, TPK3, that arose from the whole genome duplication [Source:SGD;Acc:S000003700])

HSP 1 Score: 85.8853 bits (211), Expect = 4.007e-18
Identity = 60/207 (28.99%), Postives = 106/207 (51.21%), Query Frame = 2

Query: 2021 VKGKYFLQNVEEKEEIGSGSQGTIH--RCICDGKELA----KKKYIVNIDXXXXXXXXXXXXXXXXHPHLLPFLAVAIIDTEEIDSKEVAIYSPLMKTDLYNYLCHNKTKLSHRIS--IAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEG 2617
              GKY LQ+ +    +G+GS G +H  R   +G+  A    KK+ +V +  +E   +E        HP ++        D ++I      I   +   +L++ L     +  + ++   A ++  AL+YLHS +I++RDLK  NILL+++  + + D+GF K      Y+  GTP +IAPE++    Y+  +D +SF IL++ +  G
Sbjct:   78 TSGKYSLQDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPFIIRMWGT-FQDAQQI----FMIMDYIEGGELFS-LLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTPDYIAPEVVSTKPYNKSIDWWSFGILIYEMLAG 278

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BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: CDC5 (Polo-like kinase; controls targeting and activation of Rho1p at cell division site via Rho1p guanine nucleotide exchange factors; regulates Spc72p; also functions in adaptation to DNA damage during meiosis; regulates the shape of the nucleus and expansion of the nuclear envelope during mitosis; similar to Xenopus Plx1 and S. pombe Plo1p; human homologs PLK1, PLK3 can each complement yeast cdc5 thermosensitive mutants [Source:SGD;Acc:S000004603])

HSP 1 Score: 77.0258 bits (188), Expect = 8.230e-15
Identity = 48/144 (33.33%), Postives = 76/144 (52.78%), Query Frame = 2

Query: 2354 AIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTA---LTHYSFVGTPLHIAPEIIMK--NNYDYKVDIYSFAILLWFLSEGTGKNPKGA----TSFHRVMTIDMRLERLENIPLELWNLIEACWNADPEKRP 2758
              QI  A++Y+HS  ++HRDLKL NI  + + ++ + D+G     A      Y+  GTP +IAPE++M   + + ++VDI+S  ++L+ L    GK P  A    T + R+   D    R + I  E   LI    + DP +RP
Sbjct:  185 TTQICGAIKYMHSRRVIHRDLKLGNIFFDSNYNLKIGDFGLAAVLANESERKYTICGTPNYIAPEVLMGKHSGHSFEVDIWSLGVMLYALL--IGKPPFQARDVNTIYERIKCRDFSFPRDKPISDEGKILIRDILSLDPIERP 326

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: STE20 (Cdc42p-activated signal transducing kinase; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p; member of the PAK (p21-activated kinase) family [Source:SGD;Acc:S000000999])

HSP 1 Score: 76.6406 bits (187), Expect = 1.270e-14
Identity = 48/148 (32.43%), Postives = 76/148 (51.35%), Query Frame = 2

Query: 2372 ALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKST---ALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGK--NPKGATSFHRVMTIDM-RLERLENIPLELWNLIEACWNADPEKRPKS------EYIIE 2779
             L++LHS  ++HRD+K  NILL+ +  + L D+GFC       L   + VGTP  +APE++ +  Y  KVDI+S  I++  + EG     N     + + + T    +L+  EN+   L   ++ C   +PE R  +      EYI E
Sbjct:  726 GLEFLHSKGVLHRDIKSDNILLSMEGDIKLTDFGFCAQINELNLKRTTMVGTPYWMAPEVVSRKEYGPKVDIWSLGIMIIEMIEGEPPYLNETPLRALYLIATNGTPKLKEPENLSSSLKKFLDWCLCVEPEDRASATELLHDEYITE 873

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO49816 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RG14])

HSP 1 Score: 162.54 bits (410), Expect = 1.392e-41
Identity = 160/638 (25.08%), Postives = 286/638 (44.83%), Query Frame = 2

Query:   77 NLTRVIKDYRQNRERLVKIQSSTKKTFDQIT---------EILKSDTGSLLDC--VDSN--NLNNIAADLGNFEDSDILADEQFYLKSVFEK--QVEIGNPAIAVVGQVKSGKSTFVNTLLRKNVVPQAFERCTARITRVTYSMKNFVEIISNEGVILKRKSLNTTTIPKRFLQLKENVRIDEEEINKQIKAGIHSNFLKCGIDIIDSPGLSENETLNNLSKNMIKSILPVMIYVIDGRTSVKQTDISDLLELKNAVPNLQIIYFVSKLDTDDLSETENADPIKLAELKMDIAFKKLQFNNF-IPLTFSHWSECNYFHGCSLYAFMDYTQNSRT------PETLF--HYNLFCKFEENLHHYLLQNFRNKIEEVCNFLIDFQMEVMTKIINRAQMLSDFNRINFDEINRIKRIEEKLYKKIKSAVKDSKIHLKSCLIKR-LKNESDVIVKPISEIIYPNHLNIPLDGIVSEXXXXXXXXXXXXXNVCQGLENVIKRFVEEELFQKYLEAIQAQIPFRMKNKI------SVTKSGKTNYGLCLDRRMAEIYKFNISNNLSNLDGNNTIMKFMNVIRSSIKGFLMTGLKIEFSQKSVDVKDPKWKMKQAKKCLERCDFKILADEVCKNLLEEFYKKHNEF 1897
            +L  V K++R+NR  L +I   T K F  I          E+++  T +L     VD +  NL NI    G    +  L+ E  Y ++   K  +     PA+ V GQ   GKS+ +N  L   VVP   + CTARI R+TYS   +V ++  +G  L+R+ L +  IP+ F++L  + R DE+ +N  ++AG+  +FLK GID+IDSPG SEN+ L+ L +N +KSILP +IYV+DG              L ++ P           D D+    + A+P++  E K    + KL    F IP      +  N FHG S +   ++ +  +        E LF  + + F +    LH +   +    +E  CN L       ++  I +A  L    +     INRI++ E  +++ I   ++  ++ +   +    L+ +S+V+ +  +         IP +G V       +  +     + + + N +++ +   L   +  + + +    ++N+I      +     ++  G+ +   +   Y+ + S N         I + ++ ++   K        ++  +  V V D +WK +QA   +E  D   L + + + LLE F + H+ F
Sbjct:    3 SLEEVFKEFRRNRSSLQQIHEDTLKCFQSIEKSLADKKHEELVQEMTTTLASQQQVDGSDINLENIQLVTGGESIATNLS-ESLYTEAERSKVSKFLTQTPALIVTGQTNCGKSSIINEFLGARVVPTKAQPCTARIVRMTYSETPYVRLVKRDGTELERRELKSNKIPREFIELNIDDRDDEKRVNATVEAGLCVDFLKAGIDVIDSPGTSENDVLDELVRNQMKSILPFVIYVVDGHN------------LLSSSPAKTDSSDEESDDDDNDESVKQAEPVQ--ESKKRKVYDKLVKKGFIIPCEGGRDAHPN-FHGLSAWRIGEFNKRMKMNPAWDDSEGLFKEYMDAFHRLHTCLHDFTKSSLTACVENTCNTLTSVLSRCLSFFIKKANFLKQGKKETMVMINRIRQEELTVHENILRQIEKQRLDITEVVSDGILEIKSNVLEEARTFQYSELDFVIPANGWVH----GAKAVTECRDQIWEMVFNKVRQRISSTLMAMF--SHRDEFLVELENRIKKIEQEAFPDGRRSTAGVTIHLMLVNCYEVSRS-NFRFWATKTIITRLVDFLKRLFK------FPLDVIRGKVKVGDMEWKERQASVAIEAIDVAKLVEHLMQKLLERFDECHSIF 611

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BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO49815 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RG13])

HSP 1 Score: 145.591 bits (366), Expect = 1.617e-39
Identity = 81/213 (38.03%), Postives = 121/213 (56.81%), Query Frame = 2

Query: 2201 HPHLLPFLAVAIIDTEEIDSKEVAIYSPLMKTDLYNYLCHNKTKLSHRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTI--------DMRLERLENIPLELWNLIEACWNADPEKRPKSEYIIEKLNHIF--ETIQ 2809
            HP++LP L   +I     +S +V I S  M +DL+  L    T L  R+ I + +A AL+YLHS +++HRD+KL N+L++E +   L D+G CK+  +   S VGTP  +APE++ K NY+  VD+Y+F IL+W + EG G  P+   + H +  I        D + ERL+      WNL+E CW   P++RP  + I   L  I   +TIQ
Sbjct:   11 HPNILP-LVCTVIQPGLCNSIKVLIVSERMASDLHRAL-PRLTSLRKRLEILLDVARALKYLHSLDLIHRDVKLQNVLVDEKSQGSLTDFGLCKAEGVMENSLVGTPTSMAPEMV-KQNYNKSVDVYAFGILMWRVCEGQGNQPRN-IALHPIPIIMLVRNALEDRKPERLDRFMGPCWNLMERCWATVPDQRPNFQEIESDLQEILLDKTIQ 219

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO44458 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RVW1])

HSP 1 Score: 149.058 bits (375), Expect = 9.132e-37
Identity = 107/347 (30.84%), Postives = 164/347 (47.26%), Query Frame = 2

Query: 1778 DPKWKMKQAKKCLERCDFKILADEVCKNLLEEFYKKHNEFLAVMDLENFYVQKKIELSDEIRQKLAEK-APIFAELLMLSLDVKGKYFLQNVEEKEEIGSGSQGTIHRC-ICDGKELAKKKYIVNIDXXXXXXXXXXXXXXXXHPHLLPFLAVAIIDTEEID-------SKEVAIYSPLMKTDLYNYLCHNKTKLS--HRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTID---------MRLERLENIPLELWNLIEACWNADPEKRP 2758
            D  WK K A+  L       LA  +C        K H  F + M +       ++E ++E R K+ +  AP  A L + S  ++        +   E+G G  G ++ C    G+     K +V  D        + + Y+   P  L    V+II +  ID       S  V +    ++ DLY  +   K  LS   R+ +A+ + E +++LHS  ++HRD+KL N+LL+  N   + D GFCK  A+   S VGTP+H+APE +   +YD  VD+Y+  ILLW++  GT + P    +F +  + D         +R ERL N   E W L+EACW+ DP  RP
Sbjct:  543 DSAWKRKVAQDMLTSLSETRLAKHICLQFRTRLIKSHESFTSCMRMLEANHTGRLEKTEEQRMKVRKSHAPKIARLALESWSLRDVVLYGMPQLSREVGRGQYGVVYACDRWAGRHPCAIKSVVPPDDKHWNDLALEFFYTRSLP--LHDRVVSIIGSV-IDYSYGGGSSPAVLLVMDRLQRDLYQGI---KAGLSFRARMHVAVDVVEGIRFLHSQGLVHRDIKLKNVLLDSKNRGKITDLGFCKPEAMMSGSIVGTPIHMAPE-LFSGHYDNSVDVYALGILLWYICAGTVRLP---LAFEQCASKDHLWNAVRRGVRPERLANFDEECWMLMEACWSGDPSARP 879

HSP 2 Score: 51.2174 bits (121), Expect = 2.122e-6
Identity = 51/203 (25.12%), Postives = 92/203 (45.32%), Query Frame = 2

Query:  275 ADEQFYLKSVFEKQVEIGNPAIAVVGQVKSGKSTFVNTLLRKNVVPQA----FERCTARITRVTYSMKNFVEIISNEGVILKRKSLNT-----TTIPKRFLQLKENVRIDEEEINKQIKAGIHSNFLKCGIDIIDSPGLSENETLNNLSKNMIKSILPVMIYVIDGRTSVKQTDISDLLELKNAVPNLQIIYFVSKLDTDDLS 856
            AD+   L SV EK      P I VVGQ    K   +N LL + V+P       +R + R+ R+ Y   + V ++  +   L   +LN        +P+  L+L +  + D    +   +  ++   LK G  ++ SP   E +   N+     + +LP+++Y I+ +  +   D ++LL++K   P+L I +        DL+
Sbjct:   50 ADKCQSLDSVCEKP-----PTIIVVGQTCFAKVCVINELLGEPVLPSVEDLEGDR-SWRMIRIKYGNISNVSLVLPDSFELA-AALNAYEGCWQCVPRGDLELNDEEKADPAMASAVAEISLNHALLKAGAQLVCSPSNPEGDA-ENIFSACCEDVLPILVYSIE-QDFLSDKDEAELLQIKALAPDLPIFFVKCSRKKPDLT 243

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO49580 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RGQ2])

HSP 1 Score: 122.479 bits (306), Expect = 2.165e-28
Identity = 98/338 (28.99%), Postives = 162/338 (47.93%), Query Frame = 2

Query:  335 AIAVVGQVKSGKSTFVNTLLRKNVVPQAFERCTARITRVTYSMKNFVEIISNEG-VILKRKSLNTTTIPKRFLQLKENV-RIDEEEINKQIKAGIHSNFLKCG-IDIIDSPGLSENETLNNLSKNMIKSILPVMIYVIDGRTSVKQTDISDLLELKNAVPNLQIIYFVSKLDTDDLSE--------TENADPIKLAELKMDIAFKKLQFNNFIPLTFSHWSECNYFHGCSLYAFMDYTQNSRTPETLFHYNLFCKFEENLHHYLLQNFRNKIEEVCNFLIDFQMEVMTKI----INRAQMLSDFNRINFDEINRIKRIEEKLYKKIKSAVKD--SKIH 1297
            AI VVGQ  SGKS+ +N LL    +P A   CT+RI R+ YS  N+VE+    G  +  ++S     IP+  + L ++  R D E +   +K G++++ L+ G ++++D+PG+SENE L+ + +  I  IL V+IYVIDG +S++  D   L  LK  + ++ I +  +K+DT+  +         +++   +   E KM  A+K L     I        +C  FHG S       T   R       +N F    E +    L    N +     +  D  + ++ +I    I+R  +  D   I  D I  I+ +E   + K+   VK   +K+H
Sbjct:   94 AILVVGQTNSGKSSLINELLGGTYLPTAEIPCTSRIVRICYSDNNYVEVQGPNGECVQGKQSFGKKRIPRDEIALDDDKKRSDAEWVRCVVKVGLNNSLLRGGHLELVDAPGMSENEVLDQIVQECIHGILQVVIYVIDGNSSLRTQDREFLFSLKERIDSIPIFFVCNKVDTNAKAAEFDRDSDDSDDDSSLDNVETKMRQAYKALVGYGLIDSDI-QLEDCAAFHGIS-------THEVRKARHKKIHNQFTDAFEVMKSSFLTFLDNSLNANLGYTTDLLLRILQRIFDFYISRGPLRGDLESICRD-IRGIQAVERTYFNKMCEYVKSNHTKLH 422

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BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO25348 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A8DWR2])

HSP 1 Score: 93.9745 bits (232), Expect = 1.247e-22
Identity = 49/135 (36.30%), Postives = 73/135 (54.07%), Query Frame = 2

Query: 2435 LNEDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTI--------DMRLERLENIPLELWNLIEACWNADPEKRPKSEYIIEKLNHIF--ETIQ 2809
            ++E +   L D+G CK+  +   S VGTP  +APE++ K NY+  VD+Y+F IL+W + EG G  P+   + H +  I        D + ERL+      WNL+E CW   P++RP  + I   L  I   +TIQ
Sbjct:    1 VDEKSQGSLTDFGLCKAEGVMENSLVGTPTSMAPEMV-KQNYNKSVDVYAFGILMWRVCEGQGNQPRN-IALHPIPIIMLVRNALEDRKPERLDRFMGPCWNLMERCWATVPDQRPNFQEIESDLQEILLDKTIQ 133

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BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: dstyk (dual serine/threonine and tyrosine protein kinase [Source:NCBI gene;Acc:100144388])

HSP 1 Score: 150.214 bits (378), Expect = 1.367e-36
Identity = 105/357 (29.41%), Postives = 159/357 (44.54%), Query Frame = 2

Query: 1781 PKWKMKQAKKCLERCDFKILADEVCKNLLEEFYKKHNEFLAVM-DLENFYVQKKIELSDEIRQKLAEKAPIFAELLMLSLDVKGKYFLQNVEEKEEIGSGSQGTIHRC-ICDGKELAKKKYIVNIDXXXXXXXXXXXXXXXXHP--HLLPFLAVAIIDTEEIDSKEVAIYSPL--MKTDLYNYLCHNKTKLSHRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTIDM---------RLERLENIPLELWNLIEACWNADPEKRPKSEYIIEKLNHIFETI 2806
            P+WK K A+  +E      LA  +C          H  F A +  LE  +  +     D   +   + AP  A L + S  ++            E+G G  G ++ C    G      K +V  D        + + Y+   P    L  L  ++ID        +A+   +  +  DLY  L      L  R+ IA+ + E +++LH   ++HRD+KL N+LL++ N   + D GFCK  A+   S VGTP+H+APE+     YD  VD+Y+F IL W+L  G+ K P+   +F +  + D          R ERL +   E W L+EACWN DP  RP    +   L  I E +
Sbjct:  544 PEWKRKVAQDAIESLSAAKLARSICSQFRTRLNSSHEAFAASLRQLEEGHTGRLERTEDLWLRVRKDHAPRLARLSLESRSLRDVLLHGKPRLGRELGRGQYGVVYLCESWGGHYPCALKSVVPPDDKHWNDLALEFHYTRSLPKHERLVDLHGSVIDHSYGGGSSIAVLLIMERLHRDLYTGL-KAGLSLRERLQIALDVVEGIRFLHGQGLLHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFT-GKYDNSVDVYAFGILFWYLCTGSVKLPE---AFEKCSSKDQLWNNVKKGARPERLPSFDEECWQLMEACWNGDPSLRPLLGIVEPGLQSIMERL 895

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: dstyk (dual serine/threonine and tyrosine protein kinase [Source:NCBI gene;Acc:100144388])

HSP 1 Score: 114.005 bits (284), Expect = 2.509e-25
Identity = 92/348 (26.44%), Postives = 138/348 (39.66%), Query Frame = 2

Query: 1781 PKWKMKQAKKCLERCDFKILADEVCKNLLEEFYKKHNEFLAVM-DLENFYVQKKIELSDEIRQKLAEKAPIFAELLMLSLDVKGKYFLQNVEEKEEIGSGSQGTIHRC-ICDGKELAKKKYIVNIDXXXXXXXXXXXXXXXXHP--HLLPFLAVAIIDTEEIDSKEVAIYSPL--MKTDLYNYLCHNKTKLSHRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTIDMRLERLENIPLELWNLIEACWNADPEKRPKSEYIIEKLNHIFETI 2806
            P+WK K A+  +E      LA  +C          H  F A +  LE  +  +     D   +   + AP  A L + S  ++            E+G G  G ++ C    G      K +V  D        + + Y+   P    L  L  ++ID        +A+   +  +  DLY  L      L  R+ IA+ + E +++LH   ++HRD+KL N+LL++ N   + D GFCK  A+   S VGTP+H+APE+                         TG  P                ERL +   E W L+EACWN DP  RP    +   L  I E +
Sbjct:  576 PEWKRKVAQDAIESLSAAKLARSICSQFRTRLNSSHEAFAASLRQLEEGHTGRLERTEDLWLRVRKDHAPRLARLSLESRSLRDVLLHGKPRLGRELGRGQYGVVYLCESWGGHYPCALKSVVPPDDKHWNDLALEFHYTRSLPKHERLVDLHGSVIDHSYGGGSSIAVLLIMERLHRDLYTGL-KAGLSLRERLQIALDVVEGIRFLHGQGLLHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELF------------------------TGARP----------------ERLPSFDEECWQLMEACWNGDPSLRPLLGIVEPGLQSIMERL 882

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BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: MAP3K12 (mitogen-activated protein kinase kinase kinase 12 [Source:NCBI gene;Acc:101160549])

HSP 1 Score: 95.5153 bits (236), Expect = 1.111e-19
Identity = 82/282 (29.08%), Postives = 129/282 (45.74%), Query Frame = 2

Query: 2015 LDVKGKYFLQNVEEKEEIGSGSQGTIHRCICDGKELAKKKYIVNIDXXXXXXXXXXXXXXXXHPHLLPFLAVAIIDTEEIDSKEVAIYSPLM----KTDLYNYL-CHNKTKLSHRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCK--STALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEG--TGKNPKGATSFHRVMTIDMRLERLENIPLELWNLIEACWNADPEKRPKSEYIIEKLN----HIFETIQ*MYF 2821
            LD   +   + + + + +GSG+QG +      G+E+A KK + NI        +I +    +HP+++ F  +           +   Y  +M    +  LY  L    K   S  +  A+ IA  + YLH H I+HRDLK  N+L+  D++V ++D+G  K  S   T  SF GT   +APE+I       KVDI+SF ++LW +  G    K+   +     V    ++L   ++ P     L+  CWN  P  RP    I+  L+     I  T Q  YF
Sbjct:  145 LDEGWEVPFEEISDLQWVGSGAQGAVFLGKLHGQEVAVKK-VRNI-----KETDIKHLRKLKHPNIITFKGICT---------QAPCYCIIMEYCAQGQLYEVLRAGRKITPSLLMDWAMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWEMLTGEVPYKDVDSSAIIWGVGNNSLQLPVPDSCPDSFKLLLRQCWNCKPRNRPSFRQILLHLDIASADILSTPQESYF 411

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: MAP3K12 (mitogen-activated protein kinase kinase kinase 12 [Source:NCBI gene;Acc:101160549])

HSP 1 Score: 95.1301 bits (235), Expect = 1.631e-19
Identity = 82/282 (29.08%), Postives = 129/282 (45.74%), Query Frame = 2

Query: 2015 LDVKGKYFLQNVEEKEEIGSGSQGTIHRCICDGKELAKKKYIVNIDXXXXXXXXXXXXXXXXHPHLLPFLAVAIIDTEEIDSKEVAIYSPLM----KTDLYNYL-CHNKTKLSHRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCK--STALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEG--TGKNPKGATSFHRVMTIDMRLERLENIPLELWNLIEACWNADPEKRPKSEYIIEKLN----HIFETIQ*MYF 2821
            LD   +   + + + + +GSG+QG +      G+E+A KK + NI        +I +    +HP+++ F  +           +   Y  +M    +  LY  L    K   S  +  A+ IA  + YLH H I+HRDLK  N+L+  D++V ++D+G  K  S   T  SF GT   +APE+I       KVDI+SF ++LW +  G    K+   +     V    ++L   ++ P     L+  CWN  P  RP    I+  L+     I  T Q  YF
Sbjct:  163 LDEGWEVPFEEISDLQWVGSGAQGAVFLGKLHGQEVAVKK-VRNI-----KETDIKHLRKLKHPNIITFKGICT---------QAPCYCIIMEYCAQGQLYEVLRAGRKITPSLLMDWAMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWEMLTGEVPYKDVDSSAIIWGVGNNSLQLPVPDSCPDSFKLLLRQCWNCKPRNRPSFRQILLHLDIASADILSTPQESYF 429

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: MAP3K12 (mitogen-activated protein kinase kinase kinase 12 [Source:NCBI gene;Acc:101160549])

HSP 1 Score: 95.1301 bits (235), Expect = 1.696e-19
Identity = 82/282 (29.08%), Postives = 129/282 (45.74%), Query Frame = 2

Query: 2015 LDVKGKYFLQNVEEKEEIGSGSQGTIHRCICDGKELAKKKYIVNIDXXXXXXXXXXXXXXXXHPHLLPFLAVAIIDTEEIDSKEVAIYSPLM----KTDLYNYL-CHNKTKLSHRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCK--STALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEG--TGKNPKGATSFHRVMTIDMRLERLENIPLELWNLIEACWNADPEKRPKSEYIIEKLN----HIFETIQ*MYF 2821
            LD   +   + + + + +GSG+QG +      G+E+A KK + NI        +I +    +HP+++ F  +           +   Y  +M    +  LY  L    K   S  +  A+ IA  + YLH H I+HRDLK  N+L+  D++V ++D+G  K  S   T  SF GT   +APE+I       KVDI+SF ++LW +  G    K+   +     V    ++L   ++ P     L+  CWN  P  RP    I+  L+     I  T Q  YF
Sbjct:  163 LDEGWEVPFEEISDLQWVGSGAQGAVFLGKLHGQEVAVKK-VRNI-----KETDIKHLRKLKHPNIITFKGICT---------QAPCYCIIMEYCAQGQLYEVLRAGRKITPSLLMDWAMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWEMLTGEVPYKDVDSSAIIWGVGNNSLQLPVPDSCPDSFKLLLRQCWNCKPRNRPSFRQILLHLDIASADILSTPQESYF 429

[Close]

BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000056719.1 (SMESG000056719.1)

HSP 1 Score: 1655.19 bits (4285), Expect = 0.000e+0
Identity = 845/847 (99.76%), Postives = 845/847 (99.76%), Query Frame = 2

Query:   38 MEFVNSDDQRTRENLTRVIKDYRQNRERLVKIQSSTKKTFDQITEILKSDTGSLLDCVDSNNLNNIAADLGNFEDSDILADEQFYLKSVFEKQVEIGNPAIAVVGQVKSGKSTFVNTLLRKNVVPQAFERCTARITRVTYSMKNFVEIISNEGVILKRKSLNTTTIPKRFLQLKENVRIDEEEINKQIKAGIHSNFLKCGIDIIDSPGLSENETLNNLSKNMIKSILPVMIYVIDGRTSVKQTDISDLLELKNAVPNLQIIYFVSKLDTDDLSETENADPIKLAELKMDIAFKKLQFNNFIPLTFSHWSECNYFHGCSLYAFMDYTQNSRTPETLFHYNLFCKFEENLHHYLLQNFRNKIEEVCNFLIDFQMEVMTKIINRAQMLSDFNRINFDEINRIKRIEEKLYKKIKSAVKDSKIHLKSCLIKRLKNESDVIVKPISEIIYPNHLNIPLDGIVSEXXXXXXXXXXXXXNVCQGLENVIKRFVEEELFQKYLEAIQAQIPFRMKNKISVTKSGKTNYGLCLDRRMAEIYKFNISNNLSNLDGNNTIMKFMNVIRSSIKGFLMTGLKIEFSQKSVDVKDPKWKMKQAKKCLERCDFKILADEVCKNLLEEFYKKHNEFLAVMDLENFYVQKKIELSDEIRQKLAEKAPIFAELLMLSLDVKGKYFLQNVEEKEEIGSGSQGTIHRCICDGKELAKKKYIVNIDXXXXXXXXXXXXXXXXHPHLLPFLAVAIIDTEEIDSKEVAIYSPLMKTDLYNYLCHNKTKLSHRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDI 2578
            MEFVNSDDQRTRENLTRVIKDYRQNRERLVKIQSSTKKTFDQITEILKSDTGSLLDCVDSNNLNNIAADLGNFEDSDILADEQFYLKSVFEKQVEIGNPAIAVVGQVKSGKSTFVNTLLRKNVVPQAFERCTARITRVTYSMKNFVEIISNEGVILKRKSLNTTTIPKRFLQLKENVRIDEEEINKQIKAGIHSNFLKCGIDIIDSPGLSENETLNNLSKNMIKSILPVMIYVIDGRTSVKQTDISDLLELKNAVPNLQIIYFVSKLDTDDLSETENADPIKLAELKMDIAFKKLQFNNFIPLTFSHWSECNYFHGCSLYAFMDYTQNSRTPETLFHYNLFCKFEENLHHYLLQNFRNKIEEVCNFLIDFQMEVMTKIINRAQMLSDFNRINFDEINRIKRIEEKLYKKIKSAVKDSKIHLKSCLIKRLKNESDVIVKPISEIIYPNHLNIPLDGIVSEKQQIKQCQSIIISNVCQGLENVIKRFVEEELFQKYLEAIQAQIPFRMKNKISVTKSGKTNYGLCLDRRMAEIYKFNISNNLSNLDGNNTIMKFMNVIRSSIKGFLMTGLKIEFSQKSVDVKDPKWKMKQAKKCLERCDFKILADEVCKNLLEEFYKKHNEFLAVMDLENFYVQKKIELSDEIRQKLAEKAPIFAELLMLSLDVKGKYFLQNVEEKEEIGSGSQGTIHRCICDGKELAKKKYIVNIDSIEEIAEEIYYSYSFEHPHLLPFLAVAIIDTEEIDSKEVAIYSPLMKTDLYNYLCHNKTKLSHRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYK  I
Sbjct:    1 MEFVNSDDQRTRENLTRVIKDYRQNRERLVKIQSSTKKTFDQITEILKSDTGSLLDCVDSNNLNNIAADLGNFEDSDILADEQFYLKSVFEKQVEIGNPAIAVVGQVKSGKSTFVNTLLRKNVVPQAFERCTARITRVTYSMKNFVEIISNEGVILKRKSLNTTTIPKRFLQLKENVRIDEEEINKQIKAGIHSNFLKCGIDIIDSPGLSENETLNNLSKNMIKSILPVMIYVIDGRTSVKQTDISDLLELKNAVPNLQIIYFVSKLDTDDLSETENADPIKLAELKMDIAFKKLQFNNFIPLTFSHWSECNYFHGCSLYAFMDYTQNSRTPETLFHYNLFCKFEENLHHYLLQNFRNKIEEVCNFLIDFQMEVMTKIINRAQMLSDFNRINFDEINRIKRIEEKLYKKIKSAVKDSKIHLKSCLIKRLKNESDVIVKPISEIIYPNHLNIPLDGIVSEKQQIKQCQSIIISNVCQGLENVIKRFVEEELFQKYLEAIQAQIPFRMKNKISVTKSGKTNYGLCLDRRMAEIYKFNISNNLSNLDGNNTIMKFMNVIRSSIKGFLMTGLKIEFSQKSVDVKDPKWKMKQAKKCLERCDFKILADEVCKNLLEEFYKKHNEFLAVMDLENFYVQKKIELSDEIRQKLAEKAPIFAELLMLSLDVKGKYFLQNVEEKEEIGSGSQGTIHRCICDGKELAKKKYIVNIDSIEEIAEEIYYSYSFEHPHLLPFLAVAIIDTEEIDSKEVAIYSPLMKTDLYNYLCHNKTKLSHRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKEKI 847

[Close]

BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000056697.1 (SMESG000056697.1)

HSP 1 Score: 1044.65 bits (2700), Expect = 0.000e+0
Identity = 533/933 (57.13%), Postives = 716/933 (76.74%), Query Frame = 2

Query:   56 DDQRTRENLTRVIKDYRQNRERLVKIQSSTKKTFDQITEILKSDTGSLLDCVDSNNLNNIAADLG--NFEDSDI-LADEQFYLKSVFEKQ-----VEIGNPAIAVVGQVKSGKSTFVNTLLRKNVVPQAFERCTARITRVTYSMKNFVEIISNEGVILKRKSLNTTTIPKRFLQLKENVRIDEEEINKQIKAGIHSNFLKCGIDIIDSPGLSENETLNNLSKNMIKSILPVMIYVIDGRTSVKQTDISDLLELKNAVPNLQIIYFVSKLDTDDLSETENADPIKLAELKMDIAFKKLQFNNFIPLTFSHWSECNYFHGCSLYAFMDYTQNSRTPETLFHYNLFCKFEENLHHYLLQNFRNKIEEVCNFLIDFQMEVMTKIINRAQMLSDFNRINFDEINRIKRIEEKLYKKIKSAVKDSKIHLKSCLIKRLKNESDVIVKPISEIIYPNHLNIPLDGIVSEXXXXXXXXXXXXXNVCQGLENVIKRFVEEELFQKYLEAIQAQIPFRMKNKISVTKS---GKTNYGLCLDRRMAEIYKFNISNNLSNLDGNNTIMKFMNVIRSSIKGFLMTGLKIEFSQKSVDVKDPKWKMKQAKKCLERCDFKILADEVCKNLLEEFYKKHNEFLAVMDLENFYVQKKIELSDEIRQKLAEKAPIFAELLMLSLDVKGKYFLQNVEEKEEIGSGSQGTIHRCICDGKELAKKKYIVNIDXXXXXXXXXXXXXXXXHPHLLPFLAVAIIDTEEIDSKEVAIYSPLMKTDLYNYLCHNKTKLSHRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTI-------DMRLERLENIPLELWNLIEACWNADPEKRPKSEYIIEKLNHIFE 2800
            D+ +TR+NL + I +YR+NRERL++IQSSTK+ F QITEILK  T  LL+CV+ +N+ +IA+DLG  N    +I ++ E+F  K+++EKQ     V+IGNPAIA+VGQVK+GKSTFVN LLRKNVV QA+ERCTAR+TR+TYS +N+VEI+   G +L+RK LN  TIPK++LQL +  R    EINK ++AGI S FL+ GIDIIDSPGLSEN TL NLSKNMIKSILP+MIYVIDGRTSVKQTDI+DLLELKNAVP LQIIYF+SKLDTDD +ETE +DPIKLAE KM++AFKKLQ+NNFIP +F HWSEC YFHG SLY +MDY +N RT E LFH++LF KFE  L  +L+ NF+NKI E C+ +++FQM+V+TKII RA++LSDF + N + I  I++IEE+L++KIK  +  SK  L   LI+RL++ES+ I+ PI ++ YPN +++P +G+V +K+ I+QCQ +I+S++CQGLENVIK+FVE EL+QKY +AI+ Q+  RMK++I V ++   GKT Y + L+R +A  YKFN    LSN +G+N IMK M  I +SIK F       +  ++SVDVK  +WK +QAK+CL+RCD   LA+EVCK+L+++F  KHN FL  ++ EN +V KKI +S+EIR ++AEKAP FA LLML+LDVKG+Y LQ +   E+IG G+QG ++RC C+G+E+AKK   + ++ + +IAEE+YYSY F+HP LLP +AV+I D+ E+DSK+++I++PLMKTD+  YL  NK  +  R+ IA+Q+AEALQYLH   IMHRDLKLANILL+++N+VFLADYGFCKS AL+++SFVGTP+HIAPEI+ K  YD+KVDIYS+ +LLW+L+EGTG++P+ A     +  +       +MR ERL+ I  ELW L++ACW+ +P  RP  E ++ K+  I E
Sbjct:    5 DEDKTRQNLNQAIHEYRENRERLLRIQSSTKEAFSQITEILKPTTAELLECVNIDNIAHIASDLGVINKPTEEIEISAEEFLNKTIYEKQDVNQKVDIGNPAIAIVGQVKAGKSTFVNVLLRKNVVCQAYERCTARLTRLTYSSQNYVEILDENGKVLERKKLNKPTIPKKYLQLNDEDRTKRSEINKIVRAGIKSQFLEYGIDIIDSPGLSENATLTNLSKNMIKSILPIMIYVIDGRTSVKQTDIADLLELKNAVPKLQIIYFISKLDTDDTTETEFSDPIKLAESKMELAFKKLQYNNFIPTSFKHWSECPYFHGASLYCYMDYYKNKRTEEILFHFDLFGKFEVALQSFLMINFKNKIFEACDSMLNFQMDVLTKIITRARVLSDFTKENLNHIFTIRKIEEELFEKIKGVISSSKNDLIKRLIERLEDESEAIINPIGDLEYPNSISVPENGMVIDKRLIEQCQGVIMSSLCQGLENVIKQFVESELYQKYRDAIEVQVTSRMKDEIGVHEAKCLGKTPYRMSLERILASNYKFNSLTALSNTEGHNVIMKLMQEILNSIKLFFSKLFGTDQIKESVDVKSHEWKTQQAKECLKRCDHSTLAEEVCKSLIDDFENKHNAFLLALENENRFVHKKISVSEEIRTQMAEKAPDFAGLLMLTLDVKGRYMLQGIVVNEKIGQGAQGEVYRCSCNGQEMAKKTVNLPMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKTDVSKYLKRNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRPDIESVLCKITLILE 937

[Close]

BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000056718.1 (SMESG000056718.1)

HSP 1 Score: 793.497 bits (2048), Expect = 0.000e+0
Identity = 438/915 (47.87%), Postives = 620/915 (67.76%), Query Frame = 2

Query:   95 KDYRQNRERLVKIQSSTKKTFDQITEILKSDTGSLLDCVDSNNLNNIAADLGNFEDSDILADEQFYLKSVFEKQVEIGNPAIAVVGQVKSGKSTFVNTLLRKNVVPQAFERCTARITRVTYSMKNFVEIISNEGVILKRKSLNTTTIPKRFLQLKENVRIDEEEINKQIKAGIHSNFLKCGIDIIDSPGLSENETLNNLSKNMIKSILPVMIYVIDGRTSVKQTDISDLLELKNAVPNLQIIYFVSKLDTDDLSETENADP-------IKLAELKMDIAFKKLQFNNFIPLTFSHWSECNYFHGCSLYAFMDYTQNSRTPETLFHYNLFCKFEENLHHYLLQNFRNKIEEVCNFLIDFQMEVMTKIINRAQMLSDFNRINFDEINRIKRIEEKLYKKIKSAVKDSKIHLKSCLIKRLKNESDVIVKPISEIIYPNHLNIPLDGIVSEXXXXXXXXXXXXXNVCQGLENVIKRFVEEELFQKYLEAIQAQIPFRMKNKI---SVTKSGKTNYGLCLDRRMAEIYKFNISNNLSNLDGNNTIMKFMNVIRSSIKGFLMTGLKIEFSQKSVDVKDPKWKMKQAKKCLERCDFKILADEVCKNLLEEFYKKHNEFLAVMDLENFYVQKKIELSDEIRQKLAEKA-PIFAELLMLSLDVKGKYFLQNVEEKEEIGSGSQGTIHRCICDGKELAKKKYIVNIDXXXXXXXXXXXXXXXXHPHLLPFLAVAIIDTEEIDSKEVAIYSPLMKTDLYNYLCHNKTKLSHRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTI-------DMRLERLENIPLELWNLIEACWNADPEKRPKSEYIIEKL 2785
            ++YR+NR+ L+ IQ+ T+  F  +T+ILK  T  LL+C++ N+L+   A+    ++ ++  D+  Y+  V EK V   NPAIA+VGQVK+ KST +N LLRK VV QAF RCTARITR+TYS +N+VE+  ++G +LKRK L    IP RF++L EN R + +EI K++KAGI+  FL  GID+ID+PGL+E+  L+NLSK  +K+ILP+MIYVIDG TSVKQTD+SDLLELKNA+P+L+IIYF+SKLD+ D+S  + +DP       I+L+  K+ IAFK+LQ  NFIP T++HWSEC YFHG SLY  MDY  + ++PE LF+  LF +FE  L  +LL +F N I      LI F M+V+ KII+R   + D +  N ++I RIKRIEE+L++ IK+ +   K++LK  LIK+ K ESD I K + +  YP+ + +P  GI  +   I+ CQ  I+S +C GLE +I+RFVE+ELF KY   ++      M  K+   +   SG+  Y +CL + + E YK N   N  NL+  +++ K +N I SSIK FL    ++   +   DVK  KWK  Q K CL  CDF  LAD VC NL+E     H  F   +++E  + QK I++SD I+Q L +   P+F+ LLM +LD+KG+Y +++V+  EEIG GSQ +++RC  +GKELA K   V  D + EI++E+YYSY FEH HLLPF+A++I    + +S +V+I++PLMK+D  +++  N+  L  R+ IA+Q AEALQYLH+ +IMHRDLKLANILL+ +++V+LADYG CKSTA+ + + VGTP+H+APE+I +N+YD K+DIYSF ILLW+L EG G +PK  +    V  +       D+R ERLEN+P ELW+L+ ACW+ +P  RP ++ I+E L
Sbjct:   20 QEYRENRKALIDIQTRTRTAFLNLTDILKPSTAELLECININDLSEAFAEFTLVQNENVPNDK--YVPDV-EKNVSC-NPAIAIVGQVKAAKSTMINVLLRKTVVCQAFSRCTARITRLTYSEENYVELFDSDGTLLKRKLLRAPKIPARFVRLNENDRSNIKEIRKEVKAGINCKFLMSGIDLIDTPGLNEHSLLSNLSKETVKNILPIMIYVIDGNTSVKQTDLSDLLELKNAIPDLKIIYFISKLDS-DISTEQLSDPEEIEKMKIELSIEKLSIAFKRLQNQNFIPKTYNHWSECPYFHGASLYKIMDYFNHQQSPEILFNLELFNRFENELSLFLLVHFENIITTAAYSLIYFHMDVLAKIISRGIKIKDSSEENQNQIERIKRIEEELFENIKNVLSSQKLYLKEILIKKFKTESDSIYKLVQDCEYPSSIRVPDSGITIDNNTIRLCQKFIVSIICFGLEQLIERFVEDELFSKYRSKVENHFNDNMDKKLYGKNSKFSGRNPYDMCLRKILTENYKCNFKVNPKNLEDMSSMRKLINNILSSIKIFLWKIFEVNSLKGCKDVKSQKWKHNQVKYCLLNCDFSKLADNVCINLIENLQNCHEAFNLALEIERKHFQKSIQISDNIKQSLKKNHWPVFSVLLMETLDIKGRYMMKDVKRHEEIGQGSQASVYRCTVNGKELAMKTRYVKADKLSEISDEVYYSYLFEHRHLLPFIAISI--KLQYNSAQVSIFTPLMKSDALDFIIQNEVSLVKRLMIALQTAEALQYLHNQSIMHRDLKLANILLDNEDNVYLADYGCCKSTAIANNTIVGTPIHMAPEVI-QNSYDDKIDIYSFGILLWYLVEGKGNHPKHLSVHSEVFRVLYLAAHKDVRPERLENMPDELWDLMSACWDKNPVLRPNTDSIVEIL 926

[Close]

BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000056716.1 (SMESG000056716.1)

HSP 1 Score: 743.421 bits (1918), Expect = 0.000e+0
Identity = 418/930 (44.95%), Postives = 605/930 (65.05%), Query Frame = 2

Query:   74 ENLTRVIKDYRQNRERLVKIQSSTKKTFDQITEILKSDTGSLLDCVDSNNLNNIAADLGNFED-SDI------LADEQFYLKSVFEKQVEIG--NPAIAVVGQVKSGKSTFVNTLLRKNVVPQAFERCTARITRVTYSMKNFVEIISNEGVILKRKSLNTTTIPKRFLQLKENVRIDEEEINKQIKAGIHSNFLKCGIDIIDSPGLSENETLNNLSKNMIKSILPVMIYVIDGRTSVKQTDISDLLELKNAVPNLQIIYFVSKLDTDDLSETENADPIKLAELKMDIAFKKLQFNNFIPLTFSHWSECNYFHGCSLYAFMDYTQNSRTPETLFHYNLFCKFEENLHHYLLQNFRNKIEEVCNFLIDFQMEVMTKIINRAQMLSDFNRINFDEINRIKRIEEKLYKKIKSAVKDSKIHLKSCLIKRLKNESDVIVKPISEIIYPNHLNIPLDGIVSEXXXXXXXXXXXXXNVCQGLENVIKRFVEEELFQKYLEAIQAQIPFRMKNKI---SVTKSGKTNYGLCLDRRMAEIYKFNISNNLSNLDGNNTIMKFMNVIRSSIKGFLMTGLKIEFSQKSVDVKDPKWKMKQAKKCLERCDFKILADEVCKNLLEEFYKKHNEFLAVMDLENFYVQKKIELSDEIRQKLAEKAPIFAELLMLSLDVKGKYFLQNVEEKEEIGSGSQGTIHRCICDGKELAKKKYIVNIDXXXXXXXXXXXXXXXXHPHLLPFLAVAIIDTEEIDSKEVAIYSPLMKTDLYNYLCHNKTKLSHRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTI-------DMRLERLENIPLELWNLIEACWNADPEKRPKSEYIIEKLNHIFETI 2806
            ENL + I+ Y+ + + ++ IQ +TK  F  IT+IL   + +LL+C++ +NL NI    GN E  +DI      L  +   +++ F    EI   NP IA+VG VK+GKST VN LLRKNVV QA + CTAR+TR+TYS +N+VE+++    I++RK L    IPK  ++L +  R + +E+NK I+ GI S FLK GID+IDSPGL+EN  LN L  N+I  +LPVMIYVIDG+TSVKQTDIS++L LK ++PNL IIYF+++LDTDD+SE    D IK A+ K+D  F+KLQ +N IP TF+H+SEC+ FHG SLY++MDY    ++ ET FH   FCKFE +L+  L +NF  +I      LIDFQM+V+TKII+RA+   DF   N DEI  ++++EE+L+  +KS + +SK  L   L+KRL NESD+I+  I+++ +P  + IP +   ++K      + II   +C+ L+N+I  FV++EL + +    +A +  ++ NK+   S   S K+ Y LCL+R + + YK+    +L  L   N+     N +++ I G   + L    S  + D+    W++ Q K  L  CD  +LA  +C N+L +   KH+ FL  ++ E   +QK+I LS+ IR K++ +   F  LLM +LD++ KY +++  EKE IG GSQGT++RC+C+GKE AKKK IV  D +E I+EE+YYSY FEHP+LLP +AV + D    D  E++IY+PLMK DL NY+  N   L  ++ I++++A AL+Y+H+ NIMHRDLKLANILL+E N+V+LADYGFCKS AL++YSFVGT +HIAPEI+ ++ YD K+DIYSF +LLW+L++G  + P  A      + +       ++R ERLENIP  LW+L+  CW+ +P  RP    II  +  +   I
Sbjct:    8 ENLRQTIQLYQNDLKNVLVIQENTKTAFQHITDILDPISENLLECINLDNLLNIFNVCGNTETLNDIELAISALRYDSGLVENSFRTNNEIHKENPTIAIVGSVKAGKSTLVNLLLRKNVVRQAHKTCTARLTRITYSEENYVELVNIHDQIIERKKLKNKPIPKYIVELNDEDRSNPDEVNKLIRVGIKSKFLKSGIDLIDSPGLNENHVLNLLISNIINKVLPVMIYVIDGQTSVKQTDISNILSLKVSIPNLNIIYFITRLDTDDVSELIENDHIKTAKDKLDFTFRKLQRSNLIPKTFNHYSECHNFHGASLYSYMDYCNKIKSQETDFHNEQFCKFESDLNRILSENFEREILTATKSLIDFQMDVLTKIISRAKQFVDFTNENLDEIFTMRKVEERLHNDLKSEINNSKPLLIDRLMKRLDNESDLIIDLIADMEFPKSIIIPENKAFTKKNAKFCQKHIIDL-ICKDLDNLIDNFVQDELNKNFENCFEAHLSPKIINKLKLYSCRLSNKSPYRLCLERNLTKYYKY----DLLGLKIKNSSFSIWNFLKNIITGLFRSDL----SNDTFDINSRHWRIGQTKIILNLCDKDLLAKNICNNMLHDLNVKHDRFLMNLEKEFKVIQKEINLSETIRDKISNETSSFTLLLMRTLDLQSKYLMKDSVEKEMIGQGSQGTVYRCVCNGKEYAKKKIIVPTDLLETISEEVYYSYLFEHPNLLPLIAVTVNDNIRFDCIEISIYTPLMKIDLENYMKKNILTLEQQLKISLEVANALKYIHNQNIMHRDLKLANILLDEQNNVYLADYGFCKSLALSNYSFVGTFVHIAPEIVRQSKYDQKIDIYSFGMLLWYLAKGDCEPPLFANCQSTTVKVLLEVTNKNVRPERLENIPDNLWDLMNECWDQNPSNRPNINSIISTIQDLLSEI 928

[Close]

Query:   74 ENLTRVIKDYRQNRERLVKIQSSTKKTFDQITEILKSDTGSLLDCVDSNNLNNIAADLGNFED-SDI------LADEQFYLKSVFEKQVEIG--NPAIAVVGQVKSGKSTFVNTLLRKNVVPQAFERCTARITRVTYSMKNFVEIISNEGVILKRKSLNTTTIPKRFLQLKENVRIDEEEINKQIKAGIHSNFLKCGIDIIDSPGLSENETLNNLSKNMIKSILPVMIYVIDGRTSVKQTDISDLLELKNAVPNLQIIYFVSKLDTDDLSETENADPIKLAELKMDIAFKKLQFNNFIPLTFSHWSECNYFHGCSLYAFMDYTQNSRTPETLFHYNLFCKFEENLHHYLLQNFRNKIEEVCNFLIDFQMEVMTKIINRAQMLSDFNRINFDEINRIKRIEEKLYKKIKSAVKDSKIHLKSCLIKRLKNESDVIVKPISEIIYPNHLNIPLDGIVSEXXXXXXXXXXXXXNVCQGLENVIKRFVEEELFQKYLEAIQAQIPFRMKNKI---SVTKSGKTNYGLCLDRRMAEIYKFNISNNLSNLDGNNTIMKFMNVIRSSIKGFLMTGLKIEFSQKSVDVKDPKWKMKQAKKCLERCDFKILADEVCKNLLEEFYKKHNEFLAVMDLENFYVQKKIELSDEIRQKLAEKAPIFAELLMLSLDVKGKYFLQNVEEKEEIGSGSQGTIHRCICDGKELAKKKYIVNIDXXXXXXXXXXXXXXXXHPHLLPFLAVAIIDTEEIDSKEVAIYSPLMKTDLYNYLCHNKTKLSHRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSFAILLWFLSEGTGKNPKGATSFHRVMTI-------DMRLERLENIPLELWNLIEACWNADPEKRPKSEYIIEKLNHIFETI 2806
            ENL + I+ Y+ + + ++ IQ +TK  F  IT+IL   + +LL+C++ +NL NI    GN E  +DI      L  +   +++ F    EI   NP IA+VG VK+GKST VN LLRKNVV QA + CTAR+TR+TYS +N+VE+++    I++RK L    IPK  ++L +  R + +E+NK I+ GI S FLK GID+IDSPGL+EN  LN L  N+I  +LPVMIYVIDG+TSVKQTDIS++L LK ++PNL IIYF+++LDTDD+SE    D IK A+ K+D  F+KLQ +N IP TF+H+SEC+ FHG SLY++MDY    ++ ET FH   FCKFE +L+  L +NF  +I      LIDFQM+V+TKII+RA+   DF   N DEI  ++++EE+L+  +KS + +SK  L   L+KRL NESD+I+  I+++ +P  + IP +   ++K      + II   +C+ L+N+I  FV++EL + +    +A +  ++ NK+   S   S K+ Y LCL+R + + YK+    +L  L   N+     N +++ I G   + L    S  + D+    W++ Q K  L  CD  +LA  +C N+L +   KH+ FL  ++ E   +QK+I LS+ IR K++ +   F  LLM +LD++ KY +++  EKE IG GSQGT++RC+C+GKE AKKK IV  D +E I+EE+YYSY FEHP+LLP +AV + D    D  E++IY+PLMK DL NY+  N   L  ++ I++++A AL+Y+H+ NIMHRDLKLANILL+E N+V+LADYGFCKS AL++YSFVGT +HIAPEI+ ++ YD K+DIYSF +LLW+L++G  + P  A      + +       ++R ERLENIP  LW+L+  CW+ +P  RP    II  +  +   I
Sbjct:    9 ENLRQTIQLYQNDLKNVLVIQENTKTAFQHITDILDPISENLLECINLDNLLNIFNVCGNTETLNDIELAISALRYDSGLVENSFRTNNEIHKENPTIAIVGSVKAGKSTLVNLLLRKNVVRQAHKTCTARLTRITYSEENYVELVNIHDQIIERKKLKNKPIPKYIVELNDEDRSNPDEVNKLIRVGIKSKFLKSGIDLIDSPGLNENHVLNLLISNIINKVLPVMIYVIDGQTSVKQTDISNILSLKVSIPNLNIIYFITRLDTDDVSELIENDHIKTAKDKLDFTFRKLQRSNLIPKTFNHYSECHNFHGASLYSYMDYCNKIKSQETDFHNEQFCKFESDLNRILSENFEREILTATKSLIDFQMDVLTKIISRAKQFVDFTNENLDEIFTMRKVEERLHNDLKSEINNSKPLLIDRLMKRLDNESDLIIDLIADMEFPKSIIIPENKAFTKKNAKFCQKHIIDL-ICKDLDNLIDNFVQDELNKNFENCFEAHLSPKIINKLKLYSCRLSNKSPYRLCLERNLTKYYKY----DLLGLKIKNSSFSIWNFLKNIITGLFRSDL----SNDTFDINSRHWRIGQTKIILNLCDKDLLAKNICNNMLHDLNVKHDRFLMNLEKEFKVIQKEINLSETIRDKISNETSSFTLLLMRTLDLQSKYLMKDSVEKEMIGQGSQGTVYRCVCNGKEYAKKKIIVPTDLLETISEEVYYSYLFEHPNLLPLIAVTVNDNIRFDCIEISIYTPLMKIDLENYMKKNILTLEQQLKISLEVANALKYIHNQNIMHRDLKLANILLDEQNNVYLADYGFCKSLALSNYSFVGTFVHIAPEIVRQSKYDQKIDIYSFGMLLWYLAKGDCEPPLFANCQSTTVKVLLEVTNKNVRPERLENIPDNLWDLMNECWDQNPSNRPNINSIISTIQDLLSEI 929

The following BLAST results are available for this feature:

BLAST of Protein kinase domain-containing protein vs. Ensembl Human
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
BLAST of Protein kinase domain-containing protein vs. TrEMBL
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST

BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
DSTYK	7.445e-36	29.71	dual serine/threonine and tyrosine protein kinase ...	[more]
DSTYK	2.826e-24	26.73	dual serine/threonine and tyrosine protein kinase ...	[more]
FRK	1.683e-20	30.70	fyn related Src family tyrosine kinase [Source:HGN...	[more]
STK25	2.320e-20	37.04	serine/threonine kinase 25 [Source:HGNC Symbol;Acc...	[more]
NEK7	4.476e-20	28.14	NIMA related kinase 7 [Source:HGNC Symbol;Acc:HGNC...	[more]

BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
C18H7.4	9.793e-21	27.65	Tyrosine-protein kinase [Source:UniProtKB/TrEMBL;...	[more]
src-2	3.725e-18	30.66	Tyrosine protein-kinase src-2 [Source:UniProtKB/S...	[more]
F32D8.1	2.572e-17	28.72	pep chromosome:WBcel235:V:10880837:10883399:1 gene...	[more]
gck-1	4.191e-17	34.94	Germinal center kinase 1 [Source:UniProtKB/Swiss-...	[more]
gck-1	4.280e-17	34.94	Germinal center kinase 1 [Source:UniProtKB/Swiss-...	[more]

BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
GckIII	2.181e-18	35.95	gene:FBgn0266465 transcript:FBtr0083399	[more]
Btk29A	3.804e-18	24.68	gene:FBgn0003502 transcript:FBtr0330693	[more]
Btk29A	6.372e-18	24.68	gene:FBgn0003502 transcript:FBtr0330692	[more]
Btk29A	6.440e-18	24.68	gene:FBgn0003502 transcript:FBtr0112835	[more]
Btk29A	6.440e-18	24.68	gene:FBgn0003502 transcript:FBtr0079618	[more]

BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
dstyk	5.263e-37	29.61	dual serine/threonine and tyrosine protein kinase ...	[more]
dstyk	6.103e-37	29.61	dual serine/threonine and tyrosine protein kinase ...	[more]
nek7	2.037e-19	33.13	NIMA-related kinase 7 [Source:ZFIN;Acc:ZDB-GENE-04...	[more]
map3k9	2.814e-19	28.52	mitogen-activated protein kinase kinase kinase 9 [...	[more]
stk25b	5.419e-19	37.04	serine/threonine kinase 25b [Source:ZFIN;Acc:ZDB-G...	[more]

BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
dstyk	1.921e-35	29.15	dual serine/threonine and tyrosine protein kinase ...	[more]
dstyk	1.990e-35	29.15	dual serine/threonine and tyrosine protein kinase ...	[more]
dstyk	2.454e-35	29.15	dual serine/threonine and tyrosine protein kinase ...	[more]
dstyk	2.537e-35	29.15	dual serine/threonine and tyrosine protein kinase ...	[more]
dstyk	2.594e-35	29.15	dual serine/threonine and tyrosine protein kinase ...	[more]

BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Dstyk	1.076e-35	30.00	dual serine/threonine and tyrosine protein kinase ...	[more]
Dstyk	2.441e-24	27.03	dual serine/threonine and tyrosine protein kinase ...	[more]
Nek7	1.598e-19	28.30	NIMA (never in mitosis gene a)-related expressed k...	[more]
Nek7	1.598e-19	28.30	NIMA (never in mitosis gene a)-related expressed k...	[more]
Fgfr4	2.790e-19	31.36	fibroblast growth factor receptor 4 [Source:MGI Sy...	[more]

BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q4VSN3\|DUSTY_TETNG	1.169e-37	30.61	Dual serine/threonine and tyrosine protein kinase ...	[more]
sp\|Q4VSN1\|DUSTY_DANRE	4.607e-36	29.61	Dual serine/threonine and tyrosine protein kinase ...	[more]
sp\|A2CI34\|DUSTY_PIMPR	1.063e-35	29.05	Dual serine/threonine and tyrosine protein kinase ...	[more]
sp\|Q4VSN2\|DUSTY_TAKRU	1.431e-35	30.03	Dual serine/threonine and tyrosine protein kinase ...	[more]
sp\|Q20CR4\|DUSTY_MACMU	3.394e-35	30.00	Dual serine/threonine and tyrosine protein kinase ...	[more]

BLAST of Protein kinase domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A267EZE8	2.477e-93	28.16	Protein kinase domain-containing protein (Fragment...	[more]
A0A267GJX3	5.894e-91	27.82	Protein kinase domain-containing protein (Fragment...	[more]
A0A2B4SY00	2.554e-87	26.62	Dual serine/threonine and tyrosine protein kinase ...	[more]
A0A3M6TL50	2.056e-83	26.85	Protein kinase domain-containing protein OS=Pocill...	[more]
A0A267GPS2	1.089e-82	27.10	Protein kinase domain-containing protein (Fragment...	[more]

BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
dstyk	2.674e-25	26.81	dual serine/threonine and tyrosine protein kinase ...	[more]
stk25b	5.368e-19	37.04	serine/threonine-protein kinase 25-like [Source:NC...	[more]
stk25b	7.798e-19	37.04	serine/threonine-protein kinase 25-like [Source:NC...	[more]
nek7	1.114e-18	32.05	NIMA related kinase 7 [Source:NCBI gene;Acc:103046...	[more]
nek7	1.242e-18	32.05	NIMA related kinase 7 [Source:NCBI gene;Acc:103046...	[more]

BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
stk39	4.651e-19	31.44	serine threonine kinase 39 [Source:ZFIN;Acc:ZDB-GE...	[more]
ENSPMAT00000008193.1	2.431e-18	28.08	pep scaffold:Pmarinus_7.0:GL476850:102262:127365:-...	[more]
STK36	2.781e-18	30.37	serine/threonine kinase 36 [Source:HGNC Symbol;Acc...	[more]
ENSPMAT00000002088.1	1.445e-17	32.92	pep scaffold:Pmarinus_7.0:GL478600:446:35095:-1 ge...	[more]
PRKCD	2.307e-17	45.35	protein kinase C delta [Source:HGNC Symbol;Acc:HGN...	[more]

BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5


Match Name	E-value	Identity	Description
TPK2	9.467e-20	28.70	cAMP-dependent protein kinase catalytic subunit; p...	[more]
TPK3	3.027e-18	27.31	cAMP-dependent protein kinase catalytic subunit; p...	[more]
TPK1	4.007e-18	28.99	cAMP-dependent protein kinase catalytic subunit; p...	[more]
CDC5	8.230e-15	33.33	Polo-like kinase; controls targeting and activatio...	[more]
STE20	1.270e-14	32.43	Cdc42p-activated signal transducing kinase; involv...	[more]

BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO49816	1.392e-41	25.08	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO49815	1.617e-39	38.03	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO44458	9.132e-37	30.84	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO49580	2.165e-28	28.99	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO25348	1.247e-22	36.30	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A8...	[more]

BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
dstyk	1.367e-36	29.41	dual serine/threonine and tyrosine protein kinase ...	[more]
dstyk	2.509e-25	26.44	dual serine/threonine and tyrosine protein kinase ...	[more]
MAP3K12	1.111e-19	29.08	mitogen-activated protein kinase kinase kinase 12 ...	[more]
MAP3K12	1.631e-19	29.08	mitogen-activated protein kinase kinase kinase 12 ...	[more]
MAP3K12	1.696e-19	29.08	mitogen-activated protein kinase kinase kinase 12 ...	[more]

BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000056719.1	0.000e+0	99.76	SMESG000056719.1	[more]
SMESG000056697.1	0.000e+0	57.13	SMESG000056697.1	[more]
SMESG000056718.1	0.000e+0	47.87	SMESG000056718.1	[more]
SMESG000056716.1	0.000e+0	44.95	SMESG000056716.1	[more]
SMESG000056716.1	0.000e+0	44.95	SMESG000056716.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence
protein sequence

transcript sequence

>SMED30032587 ID=SMED30032587|Name=Protein kinase domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=2861bp
GTTTAGCATTTGTAAATTTTATAATCAATTTTCGTAGATGGAATTTGTTA
ACAGTGACGATCAAAGAACTCGTGAAAATCTGACACGAGTTATAAAAGAT
TATCGTCAGAACCGAGAACGTTTAGTCAAAATTCAATCGTCAACGAAAAA
AACATTCGACCAAATAACTGAAATCCTAAAATCAGATACTGGATCTTTAT
TAGATTGTGTCGATTCAAACAATTTGAACAACATTGCTGCTGATTTGGGA
AACTTCGAGGATTCAGATATTTTAGCCGATGAGCAGTTTTATTTGAAATC
GGTCTTTGAAAAACAAGTCGAAATCGGAAATCCGGCGATTGCCGTTGTTG
GACAGGTGAAATCCGGTAAAAGCACATTTGTCAATACACTGTTGAGGAAA
AATGTCGTGCCGCAGGCATTTGAAAGATGTACTGCTAGAATAACCAGAGT
AACATATAGCATGAAAAATTTCGTGGAAATTATTAGCAATGAAGGAGTTA
TTTTGAAAAGAAAATCATTGAACACAACAACGATCCCAAAACGATTTCTT
CAACTTAAGGAAAATGTAAGAATCGACGAAGAAGAAATTAACAAGCAAAT
CAAAGCTGGAATTCACTCTAATTTTCTGAAATGTGGAATTGACATTATTG
ACTCTCCAGGTTTGAGTGAAAATGAAACCCTTAACAATCTGTCGAAAAAT
ATGATTAAAAGCATTTTGCCAGTCATGATATATGTTATCGACGGCAGGAC
GTCAGTAAAACAAACGGACATATCAGATTTATTAGAGCTAAAGAATGCAG
TTCCAAATCTTCAAATCATTTATTTTGTCTCAAAATTGGACACAGATGAT
TTGAGTGAAACAGAAAATGCAGATCCAATCAAATTGGCTGAATTAAAAAT
GGATATTGCATTTAAAAAACTTCAATTCAACAATTTCATTCCGTTAACGT
TTTCTCATTGGTCAGAATGCAACTACTTTCACGGGTGTTCTCTATATGCT
TTCATGGACTATACTCAAAACTCACGAACACCAGAAACACTCTTTCATTA
CAACTTGTTCTGTAAATTTGAAGAAAATTTGCATCATTATTTGCTGCAAA
ATTTTCGAAATAAAATTGAAGAAGTCTGTAATTTTTTGATTGATTTTCAA
ATGGAGGTCATGACCAAAATCATAAACCGAGCGCAAATGCTATCAGATTT
CAATCGGATCAATTTTGACGAAATAAATCGAATAAAACGTATCGAAGAAA
AACTCTACAAAAAAATAAAATCTGCTGTAAAAGATTCGAAAATACATTTA
AAGTCTTGTTTAATAAAACGATTGAAAAATGAATCTGATGTAATCGTTAA
GCCCATATCAGAAATTATTTATCCAAATCATCTGAATATTCCTTTAGATG
GAATCGTTTCAGAAAAACAGCAAATTAAACAATGTCAGAGTATAATAATT
TCAAATGTTTGCCAAGGTCTGGAAAATGTTATCAAACGATTTGTAGAAGA
AGAATTATTTCAAAAATATCTCGAAGCAATTCAGGCGCAAATACCATTTC
GAATGAAAAATAAAATATCTGTTACTAAATCTGGTAAAACTAATTACGGG
CTGTGCTTGGATAGGCGAATGGCAGAAATATATAAATTCAACATAAGCAA
CAATTTATCAAATTTAGATGGCAATAATACGATCATGAAATTCATGAATG
TCATTCGCTCCAGTATAAAAGGGTTTCTCATGACCGGTTTGAAGATTGAA
TTCTCACAAAAATCGGTCGACGTCAAAGATCCGAAATGGAAAATGAAGCA
GGCGAAAAAATGTTTAGAACGTTGTGACTTTAAAATTTTGGCAGATGAAG
TGTGCAAGAATTTACTTGAGGAATTCTACAAGAAGCACAATGAATTTTTA
GCAGTTATGGATTTGGAAAATTTCTATGTACAGAAAAAAATTGAATTATC
CGATGAAATCCGTCAAAAACTTGCTGAAAAAGCCCCAATATTCGCTGAAT
TATTAATGCTATCACTAGACGTTAAAGGAAAATATTTTTTACAGAATGTA
GAGGAAAAAGAGGAAATAGGCAGCGGCTCCCAGGGAACAATCCATCGATG
CATTTGTGATGGAAAAGAATTAGCAAAAAAAAAGTATATCGTAAATATTG
ATTCAATTGAAGAAATTGCTGAGGAAATTTATTATTCCTATTCATTTGAG
CATCCTCATTTACTGCCATTTCTTGCGGTAGCAATAATAGATACCGAGGA
GATAGATAGCAAAGAAGTTGCTATATACTCCCCGTTAATGAAAACTGATC
TTTACAATTATTTATGTCACAATAAAACGAAACTTTCTCATAGAATTTCA
ATTGCCATTCAAATCGCAGAAGCATTGCAATATTTACACAGTCACAATAT
TATGCACAGAGACCTCAAATTAGCAAACATACTGCTAAACGAAGATAATA
GCGTATTTCTTGCTGATTACGGGTTTTGCAAATCAACGGCCCTAACTCAT
TATTCGTTTGTTGGAACCCCATTACATATCGCACCAGAAATTATAATGAA
AAATAATTATGATTATAAAGTGGACATTTATTCTTTTGCAATTTTACTTT
GGTTTTTATCTGAGGGTACAGGAAAGAATCCGAAAGGGGCAACCAGTTTT
CATAGAGTAATGACGATAGACATGCGTCTTGAAAGATTGGAAAATATTCC
ATTGGAATTGTGGAATTTAATTGAGGCTTGTTGGAATGCAGATCCAGAAA
AAAGACCAAAATCTGAATATATAATTGAAAAATTAAATCACATATTTGAG
ACAATTCAATAAATGTATTTTTGTTTATTTGTTTGTTAAAATAAGAGACG
CTTGTTATTTT

protein sequence of SMED30032587-orf-1

>SMED30032587-orf-1 ID=SMED30032587-orf-1|Name=SMED30032587-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=925bp
MEFVNSDDQRTRENLTRVIKDYRQNRERLVKIQSSTKKTFDQITEILKSD
TGSLLDCVDSNNLNNIAADLGNFEDSDILADEQFYLKSVFEKQVEIGNPA
IAVVGQVKSGKSTFVNTLLRKNVVPQAFERCTARITRVTYSMKNFVEIIS
NEGVILKRKSLNTTTIPKRFLQLKENVRIDEEEINKQIKAGIHSNFLKCG
IDIIDSPGLSENETLNNLSKNMIKSILPVMIYVIDGRTSVKQTDISDLLE
LKNAVPNLQIIYFVSKLDTDDLSETENADPIKLAELKMDIAFKKLQFNNF
IPLTFSHWSECNYFHGCSLYAFMDYTQNSRTPETLFHYNLFCKFEENLHH
YLLQNFRNKIEEVCNFLIDFQMEVMTKIINRAQMLSDFNRINFDEINRIK
RIEEKLYKKIKSAVKDSKIHLKSCLIKRLKNESDVIVKPISEIIYPNHLN
IPLDGIVSEKQQIKQCQSIIISNVCQGLENVIKRFVEEELFQKYLEAIQA
QIPFRMKNKISVTKSGKTNYGLCLDRRMAEIYKFNISNNLSNLDGNNTIM
KFMNVIRSSIKGFLMTGLKIEFSQKSVDVKDPKWKMKQAKKCLERCDFKI
LADEVCKNLLEEFYKKHNEFLAVMDLENFYVQKKIELSDEIRQKLAEKAP
IFAELLMLSLDVKGKYFLQNVEEKEEIGSGSQGTIHRCICDGKELAKKKY
IVNIDSIEEIAEEIYYSYSFEHPHLLPFLAVAIIDTEEIDSKEVAIYSPL
MKTDLYNYLCHNKTKLSHRISIAIQIAEALQYLHSHNIMHRDLKLANILL
NEDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYKVDIYSF
AILLWFLSEGTGKNPKGATSFHRVMTIDMRLERLENIPLELWNLIEACWN
ADPEKRPKSEYIIEKLNHIFETIQ*

protein sequence of SMED30032587-orf-2

>SMED30032587-orf-2 ID=SMED30032587-orf-2|Name=SMED30032587-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=107bp
KITSVSYFNKQINKNTFIELSQICDLIFQLYIQILVFFLDLHSNKPQLNS
TIPMEYFPIFQDACLSSLLYENWLPLSDSFLYPQIKTKVKLQKNKCPLYN
HNYFSL*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0003116	parenchymal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR000719	Prot_kinase_dom
IPR027417	P-loop_NTPase
IPR022812	Dynamin_SF
IPR008271	Ser/Thr_kinase_AS
IPR011009	Kinase-like_dom_sf

Vocabulary: **molecular function**
Term	Definition
GO:0004672	protein kinase activity
GO:0005524	ATP binding
GO:0000166	nucleotide binding
GO:0004674	protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0016301	kinase activity
GO:0016740	transferase activity

Vocabulary: **biological process**
Term	Definition
GO:0006468	protein phosphorylation
GO:0007275	multicellular organism development
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0048568	embryonic organ development

Vocabulary: **cellular component**
Term	Definition
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0030054	cell junction

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 12..32
None	No IPR available	GENE3D	G3DSA:3.40.50.300		coord: 101..294 e-value: 1.8E-17 score: 65.6
None	No IPR available	GENE3D	G3DSA:1.10.510.10		coord: 660..924 e-value: 9.1E-54 score: 184.4
None	No IPR available	PANTHER	PTHR46392	FAMILY NOT NAMED	coord: 13..922
IPR000719	Protein kinase domain	SMART	SM00220	serkin_6	coord: 671..920 e-value: 7.8E-33 score: 125.1
IPR000719	Protein kinase domain	PFAM	PF00069	Pkinase	coord: 672..913 e-value: 6.0E-40 score: 137.3
IPR000719	Protein kinase domain	PROSITE	PS50011	PROTEIN_KINASE_DOM	coord: 671..921 score: 33.333
IPR022812	Dynamin superfamily	PFAM	PF00350	Dynamin_N	coord: 101..251 e-value: 7.2E-17 score: 62.0
IPR008271	Serine/threonine-protein kinase, active site	PROSITE	PS00108	PROTEIN_KINASE_ST	coord: 788..800
IPR027417	P-loop containing nucleoside triphosphate hydrolase	SUPERFAMILY	SSF52540	P-loop containing nucleoside triphosphate hydrolases	coord: 93..275
IPR011009	Protein kinase-like domain superfamily	SUPERFAMILY	SSF56112	Protein kinase-like (PK-like)	coord: 661..916