Bestrophin homolog

Overview
NameBestrophin homolog
Smed IDSMED30032556
Length (bp)1143
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Bestrophin homolog (SMED30032556) t-SNE clustered cells

Violin plots show distribution of expression levels for Bestrophin homolog (SMED30032556) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Bestrophin homolog (SMED30032556) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Bestrophin homolog (SMED30032556) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30032556

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 3

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
nervous systemSMED30032556SMESG000023666.1 dd_Smed_v4_69966_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30032556SMESG000023666.1 dd_Smed_v4_69966_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30032556SMESG000023666.1 dd_Smed_v4_69966_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Bestrophin homolog vs. Ensembl Human
Match: BEST3 (bestrophin 3 [Source:HGNC Symbol;Acc:HGNC:17105])

HSP 1 Score: 83.5741 bits (205), Expect = 4.172e-17
Identity = 61/214 (28.50%), Postives = 104/214 (48.60%), Query Frame = 1 
Query:  460 KHFLFTFNYIQQGVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQ----DTLYNG--MDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDLFFNTERVN----FEEVDYGHTSFYG 1071
            K F    + ++ G +T+ E  + N +   H+   +P  W  +L   ARNE  + ++     ++  +N Y+     +   D V  PL+YTQV TLAVY +F   L   Q       Y G  +D+YIP+ ++++F  Y G LK A  L+NP G D+++FE +  I  N  +     +E+  + P ++ +D++++             DY   SF G
Sbjct:  149 KRFPTMDHVVEAGFMTTDERKLFNHLKSPHLKYWVPFIWFGNLATKARNEGRIRDSVDLQSLMTEMNRYRSWCSLLFGYDWVGIPLVYTQVVTLAVYTFFFACLIGRQFLDPTKGYAGHDLDLYIPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWCIDRNLQVSLLAVDEMHMSLP-KMKKDIYWDDSAARPPYTLAAADYCIPSFLG 361

HSP 2 Score: 73.1738 bits (178), Expect = 1.369e-13
Identity = 44/150 (29.33%), Postives = 78/150 (52.00%), Query Frame = 2 
Query:   26 FLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLN--TALIMTIIRVHRHKLFVDIASLVKRGLVSIS 469
            F RLL +WRG I KL+  E  +F VL+  ++  YR  L G  K  F  +      Y  +IP+  +LGF++  V   +  +F  +PW  +++ L+S  +H + +   +LR  ++RY+N  + LI   +    +K F  +  +V+ G ++  
Sbjct:   17 FHRLLLKWRGSIYKLLYREFIVFAVLYTAISLVYRLLLTGVQKRYFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFVNLPWPDRLMFLISSSVHGSDEHGRLLRRTLMRYVNLTSLLIFRSVSTAVYKRFPTMDHVVEAGFMTTD 166
[Close]
BLAST of Bestrophin homolog vs. Ensembl Human
Match: BEST1 (bestrophin 1 [Source:HGNC Symbol;Acc:HGNC:12703])

HSP 1 Score: 82.4185 bits (202), Expect = 1.159e-16
Identity = 47/158 (29.75%), Postives = 84/158 (53.16%), Query Frame = 2 
Query:    2 VHTSRAAIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLN--TALIMTIIRVHRHKLFVDIASLVKRGLVSIS 469
            V  +R   F RLL  WRG I KL+  E  IFL+ +Y++ F YR AL    +++F  +      Y   IP++ +LGF++  V   +  +++ +PW  ++++L+S  +    ++  +LR  +IRY N    LI+  +    +K F     LV+ G ++ +
Sbjct:    9 VANARLGSFSRLLLCWRGSIYKLLYGEFLIFLLCYYIIRFIYRLALTEEQQLMFEKLTLYCDSYIQLIPISFVLGFYVTLVVTRWWNQYENLPWPDRLMSLVSGFVEGKDEQGRLLRRTLIRYANLGNVLILRSVSTAVYKRFPSAQHLVQAGFMTPA 166
[Close]
BLAST of Bestrophin homolog vs. Ensembl Human
Match: BEST1 (bestrophin 1 [Source:HGNC Symbol;Acc:HGNC:12703])

HSP 1 Score: 82.4185 bits (202), Expect = 1.159e-16
Identity = 47/158 (29.75%), Postives = 84/158 (53.16%), Query Frame = 2 
Query:    2 VHTSRAAIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLN--TALIMTIIRVHRHKLFVDIASLVKRGLVSIS 469
            V  +R   F RLL  WRG I KL+  E  IFL+ +Y++ F YR AL    +++F  +      Y   IP++ +LGF++  V   +  +++ +PW  ++++L+S  +    ++  +LR  +IRY N    LI+  +    +K F     LV+ G ++ +
Sbjct:    9 VANARLGSFSRLLLCWRGSIYKLLYGEFLIFLLCYYIIRFIYRLALTEEQQLMFEKLTLYCDSYIQLIPISFVLGFYVTLVVTRWWNQYENLPWPDRLMSLVSGFVEGKDEQGRLLRRTLIRYANLGNVLILRSVSTAVYKRFPSAQHLVQAGFMTPA 166
[Close]
BLAST of Bestrophin homolog vs. Ensembl Human
Match: BEST3 (bestrophin 3 [Source:HGNC Symbol;Acc:HGNC:17105])

HSP 1 Score: 82.4185 bits (202), Expect = 2.243e-16
Identity = 61/214 (28.50%), Postives = 104/214 (48.60%), Query Frame = 1 
Query:  460 KHFLFTFNYIQQGVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQ----DTLYNG--MDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDLFFNTERVN----FEEVDYGHTSFYG 1071
            K F    + ++ G +T+ E  + N +   H+   +P  W  +L   ARNE  + ++     ++  +N Y+     +   D V  PL+YTQV TLAVY +F   L   Q       Y G  +D+YIP+ ++++F  Y G LK A  L+NP G D+++FE +  I  N  +     +E+  + P ++ +D++++             DY   SF G
Sbjct:  149 KRFPTMDHVVEAGFMTTDERKLFNHLKSPHLKYWVPFIWFGNLATKARNEGRIRDSVDLQSLMTEMNRYRSWCSLLFGYDWVGIPLVYTQVVTLAVYTFFFACLIGRQFLDPTKGYAGHDLDLYIPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWCIDRNLQVSLLAVDEMHMSLP-KMKKDIYWDDSAARPPYTLAAADYCIPSFLG 361

HSP 2 Score: 72.0182 bits (175), Expect = 5.848e-13
Identity = 44/150 (29.33%), Postives = 78/150 (52.00%), Query Frame = 2 
Query:   26 FLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLN--TALIMTIIRVHRHKLFVDIASLVKRGLVSIS 469
            F RLL +WRG I KL+  E  +F VL+  ++  YR  L G  K  F  +      Y  +IP+  +LGF++  V   +  +F  +PW  +++ L+S  +H + +   +LR  ++RY+N  + LI   +    +K F  +  +V+ G ++  
Sbjct:   17 FHRLLLKWRGSIYKLLYREFIVFAVLYTAISLVYRLLLTGVQKRYFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFVNLPWPDRLMFLISSSVHGSDEHGRLLRRTLMRYVNLTSLLIFRSVSTAVYKRFPTMDHVVEAGFMTTD 166
[Close]
BLAST of Bestrophin homolog vs. Ensembl Human
Match: BEST1 (bestrophin 1 [Source:HGNC Symbol;Acc:HGNC:12703])

HSP 1 Score: 81.6481 bits (200), Expect = 3.513e-16
Identity = 47/158 (29.75%), Postives = 84/158 (53.16%), Query Frame = 2 
Query:    2 VHTSRAAIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLN--TALIMTIIRVHRHKLFVDIASLVKRGLVSIS 469
            V  +R   F RLL  WRG I KL+  E  IFL+ +Y++ F YR AL    +++F  +      Y   IP++ +LGF++  V   +  +++ +PW  ++++L+S  +    ++  +LR  +IRY N    LI+  +    +K F     LV+ G ++ +
Sbjct:    9 VANARLGSFSRLLLCWRGSIYKLLYGEFLIFLLCYYIIRFIYRLALTEEQQLMFEKLTLYCDSYIQLIPISFVLGFYVTLVVTRWWNQYENLPWPDRLMSLVSGFVEGKDEQGRLLRRTLIRYANLGNVLILRSVSTAVYKRFPSAQHLVQAGFMTPA 166

HSP 2 Score: 67.781 bits (164), Expect = 1.133e-11
Identity = 38/113 (33.63%), Postives = 66/113 (58.41%), Query Frame = 1 
Query:  697 DQVSFPLIYTQVNTLAVYAYFMFSLFASQ----DTLYNG--MDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDLFFN 1017
            D +S PL+YTQV T+AVY++F+  L   Q       Y G  +D+ +PV + ++F  Y+G LK A  L+NP G D+++FE + ++  N  +     +E+    P ++  D+++N
Sbjct:  228 DWISIPLVYTQVVTVAVYSFFLTCLVGRQFLNPAKAYPGHELDLVVPVFTFLQFFFYVGWLKVAEQLINPFGEDDDDFETNWIVDRNLQVSLLAVDEMHQDLP-RMEPDMYWN 339
[Close]
BLAST of Bestrophin homolog vs. Ensembl Celegans
Match: best-22 (Bestrophin homolog 22 [Source:UniProtKB/Swiss-Prot;Acc:Q23369])

HSP 1 Score: 96.2857 bits (238), Expect = 6.082e-34
Identity = 56/182 (30.77%), Postives = 103/182 (56.59%), Query Frame = 1 
Query:  496 GVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQDTLY----NGMDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDLFFNTERV 1029
            G++T +E D+++ I   +      I WS++LV   + +  + + +    IV+ I +++  L  ++  D V  PL+Y QV  LAV  YFM  L   Q  +     +G+D+++P+ ++V+FLVYMG +K A  LLNP+G D+++ E + +I  N + G+ +  E +   P Q  +D F+  +++
Sbjct:  162 GLMTHEEMDILDHIKDPYSRYWTSIQWSLNLVYECQKKGKVDSYYLMNKIVDEIGKFRHGLASLLKYDWVPVPLVYPQVIFLAVRIYFMICLIGRQFIVTGPNPSGIDLWLPITTMVQFLVYMGWMKVAEALLNPLGEDDDDLECNYIIDKNLITGYSMVEEHMAKTPAQK-KDEFWGIDKI 342

HSP 2 Score: 67.0106 bits (162), Expect = 6.082e-34
Identity = 41/150 (27.33%), Postives = 80/150 (53.33%), Query Frame = 2 
Query:   26 FLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQ--SKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRY--LNTALIMTIIRVHRHKLFVDIASLVKRGLVS 463
            F  LL RWRG + K V  +L ++  +F +++  YR+ L+ + + +F  +++  FD +  + IP+  +LGFF+  V A +      I WI     L + ++    +   ++R +++RY  L+ AL++  I +   K F  + +L   GL++
Sbjct:   17 FFSLLLRWRGSVWKAVFGQLAVWTAVFLLISCIYRYMLSPSQQDVFEQLIR-YFDNKLDANIPLTFLLGFFVSFVVARWGSILNGIGWIDDASLLFATYIRGADEETRVIRRNLVRYLVLSQALVLRDISMQVRKRFPTMDTLAASGLMT 165
[Close]
BLAST of Bestrophin homolog vs. Ensembl Celegans
Match: best-22 (Bestrophin homolog 22 [Source:UniProtKB/Swiss-Prot;Acc:Q23369])

HSP 1 Score: 96.2857 bits (238), Expect = 6.996e-34
Identity = 56/182 (30.77%), Postives = 103/182 (56.59%), Query Frame = 1 
Query:  496 GVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQDTLY----NGMDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDLFFNTERV 1029
            G++T +E D+++ I   +      I WS++LV   + +  + + +    IV+ I +++  L  ++  D V  PL+Y QV  LAV  YFM  L   Q  +     +G+D+++P+ ++V+FLVYMG +K A  LLNP+G D+++ E + +I  N + G+ +  E +   P Q  +D F+  +++
Sbjct:  162 GLMTHEEMDILDHIKDPYSRYWTSIQWSLNLVYECQKKGKVDSYYLMNKIVDEIGKFRHGLASLLKYDWVPVPLVYPQVIFLAVRIYFMICLIGRQFIVTGPNPSGIDLWLPITTMVQFLVYMGWMKVAEALLNPLGEDDDDLECNYIIDKNLITGYSMVEEHMAKTPAQK-KDEFWGIDKI 342

HSP 2 Score: 67.0106 bits (162), Expect = 6.996e-34
Identity = 41/150 (27.33%), Postives = 80/150 (53.33%), Query Frame = 2 
Query:   26 FLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQ--SKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRY--LNTALIMTIIRVHRHKLFVDIASLVKRGLVS 463
            F  LL RWRG + K V  +L ++  +F +++  YR+ L+ + + +F  +++  FD +  + IP+  +LGFF+  V A +      I WI     L + ++    +   ++R +++RY  L+ AL++  I +   K F  + +L   GL++
Sbjct:   17 FFSLLLRWRGSVWKAVFGQLAVWTAVFLLISCIYRYMLSPSQQDVFEQLIR-YFDNKLDANIPLTFLLGFFVSFVVARWGSILNGIGWIDDASLLFATYIRGADEETRVIRRNLVRYLVLSQALVLRDISMQVRKRFPTMDTLAASGLMT 165
[Close]
BLAST of Bestrophin homolog vs. Ensembl Celegans
Match: best-24 (Bestrophin homolog 24 [Source:UniProtKB/Swiss-Prot;Acc:P34672])

HSP 1 Score: 85.1149 bits (209), Expect = 3.692e-32
Identity = 57/197 (28.93%), Postives = 100/197 (50.76%), Query Frame = 1 
Query:  451 RFSKHFLFTFNYIQQGVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQDTL------YNGMDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDLFFNTE 1023
            R  + F      +  G +   E D  + I Y +    +P  W+ SL   AR + L+ + +  V + + I +++  L  I   D V  P++Y Q+  LAV+ YF+  L A Q  +         +D+Y P+ S ++F+ YMG +K A  +LNP G D+++FE + +I  N  +   + ++  D AP+ L +D F++ E
Sbjct:  146 RTRRRFPTLDTVVAAGFMMPHEKDRFDEIQYKYSKYWVPFQWAFSLTYEARKKGLIESDYYQVVVQDEIKKFRTGLAWICNYDWVPIPIMYPQLVCLAVHTYFLVCLLARQYVVSEHADNKTEIDLYFPIMSTLQFIFYMGWMKVAEAMLNPFGEDDDDFECNALIDRNITMVLMMVDQGYDRAPD-LKRDDFWDEE 341

HSP 2 Score: 72.0182 bits (175), Expect = 3.692e-32
Identity = 42/130 (32.31%), Postives = 74/130 (56.92%), Query Frame = 2 
Query:    2 VHTSRAAIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLNTALIM 391
            V TS+     +LL +WRG I K VI+EL ++LVL+ +L+  YR ALN   +  F  IV+      S IP+  +LGFF+ +V   +   +++I +I  I  + + ++   +++  + R +I+RY   A ++
Sbjct:    9 VSTSKPWTLFKLLLKWRGSIWKAVILELAVWLVLYGILSVIYRTALNPGQQRTFERIVQYCDSRLSYIPLNFMLGFFVTAVVNRWTYLYQIIGFIDNIGLMAAEYVRGRTEQARMYRRNIVRYCELAQVL 138
[Close]
BLAST of Bestrophin homolog vs. Ensembl Celegans
Match: best-22 (Bestrophin homolog 22 [Source:UniProtKB/Swiss-Prot;Acc:Q23369])

HSP 1 Score: 89.3521 bits (220), Expect = 6.767e-32
Identity = 52/159 (32.70%), Postives = 91/159 (57.23%), Query Frame = 1 
Query:  496 GVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQDTLY----NGMDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCI 960
            G++T +E D+++ I   +      I WS++LV   + +  + + +    IV+ I +++  L  ++  D V  PL+Y QV  LAV  YFM  L   Q  +     +G+D+++P+ ++V+FLVYMG +K A  LLNP+G D+++ E + +I  N + G  I
Sbjct:  162 GLMTHEEMDILDHIKDPYSRYWTSIQWSLNLVYECQKKGKVDSYYLMNKIVDEIGKFRHGLASLLKYDWVPVPLVYPQVIFLAVRIYFMICLIGRQFIVTGPNPSGIDLWLPITTMVQFLVYMGWMKVAEALLNPLGEDDDDLECNYIIDKNLITGLSI 320

HSP 2 Score: 67.0106 bits (162), Expect = 6.767e-32
Identity = 41/150 (27.33%), Postives = 80/150 (53.33%), Query Frame = 2 
Query:   26 FLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQ--SKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRY--LNTALIMTIIRVHRHKLFVDIASLVKRGLVS 463
            F  LL RWRG + K V  +L ++  +F +++  YR+ L+ + + +F  +++  FD +  + IP+  +LGFF+  V A +      I WI     L + ++    +   ++R +++RY  L+ AL++  I +   K F  + +L   GL++
Sbjct:   17 FFSLLLRWRGSVWKAVFGQLAVWTAVFLLISCIYRYMLSPSQQDVFEQLIR-YFDNKLDANIPLTFLLGFFVSFVVARWGSILNGIGWIDDASLLFATYIRGADEETRVIRRNLVRYLVLSQALVLRDISMQVRKRFPTMDTLAASGLMT 165
[Close]
BLAST of Bestrophin homolog vs. Ensembl Celegans
Match: best-22 (Bestrophin homolog 22 [Source:UniProtKB/Swiss-Prot;Acc:Q23369])

HSP 1 Score: 88.9669 bits (219), Expect = 7.111e-32
Identity = 52/159 (32.70%), Postives = 91/159 (57.23%), Query Frame = 1 
Query:  496 GVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQDTLY----NGMDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCI 960
            G++T +E D+++ I   +      I WS++LV   + +  + + +    IV+ I +++  L  ++  D V  PL+Y QV  LAV  YFM  L   Q  +     +G+D+++P+ ++V+FLVYMG +K A  LLNP+G D+++ E + +I  N + G  I
Sbjct:  162 GLMTHEEMDILDHIKDPYSRYWTSIQWSLNLVYECQKKGKVDSYYLMNKIVDEIGKFRHGLASLLKYDWVPVPLVYPQVIFLAVRIYFMICLIGRQFIVTGPNPSGIDLWLPITTMVQFLVYMGWMKVAEALLNPLGEDDDDLECNYIIDKNLITGLSI 320

HSP 2 Score: 67.3958 bits (163), Expect = 7.111e-32
Identity = 41/150 (27.33%), Postives = 80/150 (53.33%), Query Frame = 2 
Query:   26 FLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQ--SKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRY--LNTALIMTIIRVHRHKLFVDIASLVKRGLVS 463
            F  LL RWRG + K V  +L ++  +F +++  YR+ L+ + + +F  +++  FD +  + IP+  +LGFF+  V A +      I WI     L + ++    +   ++R +++RY  L+ AL++  I +   K F  + +L   GL++
Sbjct:   17 FFSLLLRWRGSVWKAVFGQLAVWTAVFLLISCIYRYMLSPSQQDVFEQLIR-YFDNKLDANIPLTFLLGFFVSFVVARWGSILNGIGWIDDASLLFATYIRGADEETRVIRRNLVRYLVLSQALVLRDISMQVRKRFPTMDTLAASGLMT 165
[Close]
BLAST of Bestrophin homolog vs. Ensembl Fly
Match: Best3 (gene:FBgn0036492 transcript:FBtr0075618)

HSP 1 Score: 91.2781 bits (225), Expect = 3.848e-33
Identity = 60/186 (32.26%), Postives = 106/186 (56.99%), Query Frame = 1 
Query:  487 IQQGVLTSKEADMINAXXXXXXXXXX---XXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQ----DTLY--NGMDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDLFFN 1017
            I+ G+L + EA+++ A+            PI W+ S+V  AR E  + +      +++ +N+++     +I  D +S PL+YTQV TLAVY+YF+ S+F  Q    D  +  N +  Y P+ S +EF  +MG LK A  L+ P G+D+++FE++ +I  N  + + I +E+ +  P QL +D +++
Sbjct:  159 IEVGLLNANEANIMKAMDVKFPKHPKYWMPIVWAASIVTRARKEGRIWDDFSLKSMIDELNKFRAGCNMLIHYDTISVPLVYTQVVTLAVYSYFVASIFGHQWIDRDIKHYNNIVSYYFPLFSTLEFFFFMGWLKVAETLICPFGDDDDDFELNWLIDRNLQVSYLIVDEMHNDHP-QLVRDQYWD 343

HSP 2 Score: 69.707 bits (169), Expect = 3.848e-33
Identity = 38/126 (30.16%), Postives = 66/126 (52.38%), Query Frame = 2 
Query:   20 AIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLNTALIMTI 397
              F +LL RWR  I K++ ++L  FL  FY +   YR+AL    K +F DIV     Y + IP++ +LGF++  +   +  ++  +PW   +   +S  +    +   ++R  I+RY+  AL M +
Sbjct:   16 GCFWKLLMRWRASIYKIIWVDLLAFLSCFYFMAVIYRYALRDVDKPVFEDIVMYCHSYSNLIPLSFVLGFYVGIIIERWWNQYITVPWPDPLAVYVSALVRGQDEHGRLMRRTIMRYVCLALTMVL 141
[Close]
BLAST of Bestrophin homolog vs. Ensembl Fly
Match: Best1 (gene:FBgn0040238 transcript:FBtr0337020)

HSP 1 Score: 99.3673 bits (246), Expect = 2.421e-22
Identity = 59/171 (34.50%), Postives = 92/171 (53.80%), Query Frame = 2 
Query:    2 VHTSRA-AIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLNTALIMTIIRVHR--HKLFVDIASLVKRGLVSISYLLLI-IFNKVY 502
            V T R    FL+LL RWRG I KLV ++L  FL ++Y +N  YRF LN   K  F  IV+    Y+  IP++ +LGF++  V   +  ++  IPW   I   +S ++H   +R  ++R  I+RY+   L M +  V     K F  + +LV+ GL++ +   +I   NK +
Sbjct:    9 VATCRGFGCFLKLLLRWRGSIYKLVWLDLLAFLTIYYAINMVYRFGLNPAQKETFEAIVQYCDSYRELIPLSFVLGFYVSIVMTRWWNQYTSIPWPDPIAVFVSSNVHGQDERGRMMRRTIMRYVCLCLTMVLANVSPRVKKRFPGLNNLVEAGLLNDNEKTIIETMNKAF 179

HSP 2 Score: 98.9821 bits (245), Expect = 4.158e-22
Identity = 63/202 (31.19%), Postives = 106/202 (52.48%), Query Frame = 1 
Query:  448 KRFSKHFLFTFNYIQQGVLTSKEADMI---NAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQ--------DTLY-NGMDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDLFFN 1017
             R  K F    N ++ G+L   E  +I   N          +PI W+ S++  AR E  + +      I++ +N+++     +I  D +S PL+YTQV TLAVY+YF+      Q        +T Y N +D+Y PV + ++F  YMG LK A  L+NP G D+++FE++ ++  N  + + I +E+    PE L +D +++
Sbjct:  146 PRVKKRFPGLNNLVEAGLLNDNEKTIIETMNKAFPRPSKHWLPIVWAASIITRARKEGRIRDDFAVKTIIDELNKFRGQCGLLISYDTISVPLVYTQVVTLAVYSYFLTCCMGQQWTDGKVVGNTTYLNKVDLYFPVFTTLQFFFYMGWLKVAESLINPFGEDDDDFEVNWMVDRNLQVSYLIVDEMHHDHPE-LLKDQYWD 346
[Close]
BLAST of Bestrophin homolog vs. Ensembl Fly
Match: Best1 (gene:FBgn0040238 transcript:FBtr0306023)

HSP 1 Score: 99.3673 bits (246), Expect = 2.582e-22
Identity = 59/171 (34.50%), Postives = 92/171 (53.80%), Query Frame = 2 
Query:    2 VHTSRA-AIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLNTALIMTIIRVHR--HKLFVDIASLVKRGLVSISYLLLI-IFNKVY 502
            V T R    FL+LL RWRG I KLV ++L  FL ++Y +N  YRF LN   K  F  IV+    Y+  IP++ +LGF++  V   +  ++  IPW   I   +S ++H   +R  ++R  I+RY+   L M +  V     K F  + +LV+ GL++ +   +I   NK +
Sbjct:    9 VATCRGFGCFLKLLLRWRGSIYKLVWLDLLAFLTIYYAINMVYRFGLNPAQKETFEAIVQYCDSYRELIPLSFVLGFYVSIVMTRWWNQYTSIPWPDPIAVFVSSNVHGQDERGRMMRRTIMRYVCLCLTMVLANVSPRVKKRFPGLNNLVEAGLLNDNEKTIIETMNKAF 179

HSP 2 Score: 98.9821 bits (245), Expect = 4.195e-22
Identity = 63/202 (31.19%), Postives = 106/202 (52.48%), Query Frame = 1 
Query:  448 KRFSKHFLFTFNYIQQGVLTSKEADMI---NAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQ--------DTLY-NGMDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDLFFN 1017
             R  K F    N ++ G+L   E  +I   N          +PI W+ S++  AR E  + +      I++ +N+++     +I  D +S PL+YTQV TLAVY+YF+      Q        +T Y N +D+Y PV + ++F  YMG LK A  L+NP G D+++FE++ ++  N  + + I +E+    PE L +D +++
Sbjct:  146 PRVKKRFPGLNNLVEAGLLNDNEKTIIETMNKAFPRPSKHWLPIVWAASIITRARKEGRIRDDFAVKTIIDELNKFRGQCGLLISYDTISVPLVYTQVVTLAVYSYFLTCCMGQQWTDGKVVGNTTYLNKVDLYFPVFTTLQFFFYMGWLKVAESLINPFGEDDDDFEVNWMVDRNLQVSYLIVDEMHHDHPE-LLKDQYWD 346
[Close]
BLAST of Bestrophin homolog vs. Ensembl Fly
Match: Best1 (gene:FBgn0040238 transcript:FBtr0082183)

HSP 1 Score: 98.9821 bits (245), Expect = 3.182e-22
Identity = 59/171 (34.50%), Postives = 92/171 (53.80%), Query Frame = 2 
Query:    2 VHTSRA-AIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLNTALIMTIIRVHR--HKLFVDIASLVKRGLVSISYLLLI-IFNKVY 502
            V T R    FL+LL RWRG I KLV ++L  FL ++Y +N  YRF LN   K  F  IV+    Y+  IP++ +LGF++  V   +  ++  IPW   I   +S ++H   +R  ++R  I+RY+   L M +  V     K F  + +LV+ GL++ +   +I   NK +
Sbjct:    9 VATCRGFGCFLKLLLRWRGSIYKLVWLDLLAFLTIYYAINMVYRFGLNPAQKETFEAIVQYCDSYRELIPLSFVLGFYVSIVMTRWWNQYTSIPWPDPIAVFVSSNVHGQDERGRMMRRTIMRYVCLCLTMVLANVSPRVKKRFPGLNNLVEAGLLNDNEKTIIETMNKAF 179

HSP 2 Score: 98.9821 bits (245), Expect = 3.709e-22
Identity = 63/201 (31.34%), Postives = 106/201 (52.74%), Query Frame = 1 
Query:  451 RFSKHFLFTFNYIQQGVLTSKEADMI---NAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQ--------DTLY-NGMDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDLFFN 1017
            R  K F    N ++ G+L   E  +I   N          +PI W+ S++  AR E  + +      I++ +N+++     +I  D +S PL+YTQV TLAVY+YF+      Q        +T Y N +D+Y PV + ++F  YMG LK A  L+NP G D+++FE++ ++  N  + + I +E+    PE L +D +++
Sbjct:  147 RVKKRFPGLNNLVEAGLLNDNEKTIIETMNKAFPRPSKHWLPIVWAASIITRARKEGRIRDDFAVKTIIDELNKFRGQCGLLISYDTISVPLVYTQVVTLAVYSYFLTCCMGQQWTDGKVVGNTTYLNKVDLYFPVFTTLQFFFYMGWLKVAESLINPFGEDDDDFEVNWMVDRNLQVSYLIVDEMHHDHPE-LLKDQYWD 346
[Close]
BLAST of Bestrophin homolog vs. Ensembl Fly
Match: Best1 (gene:FBgn0040238 transcript:FBtr0114590)

HSP 1 Score: 98.9821 bits (245), Expect = 3.495e-22
Identity = 59/171 (34.50%), Postives = 92/171 (53.80%), Query Frame = 2 
Query:    2 VHTSRA-AIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLNTALIMTIIRVHR--HKLFVDIASLVKRGLVSISYLLLI-IFNKVY 502
            V T R    FL+LL RWRG I KLV ++L  FL ++Y +N  YRF LN   K  F  IV+    Y+  IP++ +LGF++  V   +  ++  IPW   I   +S ++H   +R  ++R  I+RY+   L M +  V     K F  + +LV+ GL++ +   +I   NK +
Sbjct:    9 VATCRGFGCFLKLLLRWRGSIYKLVWLDLLAFLTIYYAINMVYRFGLNPAQKETFEAIVQYCDSYRELIPLSFVLGFYVSIVMTRWWNQYTSIPWPDPIAVFVSSNVHGQDERGRMMRRTIMRYVCLCLTMVLANVSPRVKKRFPGLNNLVEAGLLNDNEKTIIETMNKAF 179

HSP 2 Score: 98.5969 bits (244), Expect = 4.854e-22
Identity = 63/202 (31.19%), Postives = 106/202 (52.48%), Query Frame = 1 
Query:  448 KRFSKHFLFTFNYIQQGVLTSKEADMI---NAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQ--------DTLY-NGMDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDLFFN 1017
             R  K F    N ++ G+L   E  +I   N          +PI W+ S++  AR E  + +      I++ +N+++     +I  D +S PL+YTQV TLAVY+YF+      Q        +T Y N +D+Y PV + ++F  YMG LK A  L+NP G D+++FE++ ++  N  + + I +E+    PE L +D +++
Sbjct:  146 PRVKKRFPGLNNLVEAGLLNDNEKTIIETMNKAFPRPSKHWLPIVWAASIITRARKEGRIRDDFAVKTIIDELNKFRGQCGLLISYDTISVPLVYTQVVTLAVYSYFLTCCMGQQWTDGKVVGNTTYLNKVDLYFPVFTTLQFFFYMGWLKVAESLINPFGEDDDDFEVNWMVDRNLQVSYLIVDEMHHDHPE-LLKDQYWD 346
[Close]
BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Match: best4 (bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6])

HSP 1 Score: 88.1965 bits (217), Expect = 4.948e-19
Identity = 50/167 (29.94%), Postives = 89/167 (53.29%), Query Frame = 1 
Query:  451 RFSKHFLFTFNYIQQGVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQ----DTLYNGMDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYN 939
            R  K F    + ++ G +T+ E   +N +        +P++W  +L   AR E  + +      +++ +N Y+     +   D +S PL+YTQV T+AVY++F FSL   Q     +    +D+YIP+ +++EF  Y G LK    ++NP G D+++FE +++I  N
Sbjct:  146 RVRKRFTTLEDIVEAGFMTTDELRKLNHLYSDFNKYWMPLAWFANLASQARKEGRVKDDIALRLLMDELNNYRSKCSMLFHYDWISIPLVYTQVVTVAVYSFFTFSLIGRQFVKPASSEEHLDLYIPIFTLLEFFFYAGWLKVGELIINPFGEDDDDFETNQLIDRN 312

HSP 2 Score: 79.337 bits (194), Expect = 6.419e-16
Identity = 48/174 (27.59%), Postives = 88/174 (50.57%), Query Frame = 2 
Query:    2 VHTSRAAIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLN--TALIMTIIRVHRHKLFVDIASLVKRGLVSISYL-----LLIIFNKVY 502
            V  ++   F +LL RW+G I KL+  E  +F +L+  ++  YR  LN N + IF  + +    +   IPM+ +LGF++   +  +  ++   P    ++ ++S ++H T +R  +LR  ++RY N  + LI+  I     K F  +  +V+ G ++   L     L   FNK +
Sbjct:    9 VANAKFGGFSKLLFRWKGSIYKLLYREFLVFCLLYTFISILYRCVLNNNQQEIFARLARHCNKFAKLIPMSFVLGFYVTQAFQRWWGQYTSFPLPDNLMMVVSGNVHGTDERGRLLRRTLMRYANLSSVLILRSISTRVRKRFTTLEDIVEAGFMTTDELRKLNHLYSDFNKYW 182
[Close]
BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Match: best4 (bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6])

HSP 1 Score: 87.8113 bits (216), Expect = 5.485e-19
Identity = 50/167 (29.94%), Postives = 89/167 (53.29%), Query Frame = 1 
Query:  451 RFSKHFLFTFNYIQQGVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQ----DTLYNGMDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYN 939
            R  K F    + ++ G +T+ E   +N +        +P++W  +L   AR E  + +      +++ +N Y+     +   D +S PL+YTQV T+AVY++F FSL   Q     +    +D+YIP+ +++EF  Y G LK    ++NP G D+++FE +++I  N
Sbjct:  146 RVRKRFTTLEDIVEAGFMTTDELRKLNHLYSDFNKYWMPLAWFANLASQARKEGRVKDDIALRLLMDELNNYRSKCSMLFHYDWISIPLVYTQVVTVAVYSFFTFSLIGRQFVKPASSEEHLDLYIPIFTLLEFFFYAGWLKVGELIINPFGEDDDDFETNQLIDRN 312

HSP 2 Score: 78.9518 bits (193), Expect = 5.835e-16
Identity = 48/174 (27.59%), Postives = 88/174 (50.57%), Query Frame = 2 
Query:    2 VHTSRAAIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLN--TALIMTIIRVHRHKLFVDIASLVKRGLVSISYL-----LLIIFNKVY 502
            V  ++   F +LL RW+G I KL+  E  +F +L+  ++  YR  LN N + IF  + +    +   IPM+ +LGF++   +  +  ++   P    ++ ++S ++H T +R  +LR  ++RY N  + LI+  I     K F  +  +V+ G ++   L     L   FNK +
Sbjct:    9 VANAKFGGFSKLLFRWKGSIYKLLYREFLVFCLLYTFISILYRCVLNNNQQEIFARLARHCNKFAKLIPMSFVLGFYVTQAFQRWWGQYTSFPLPDNLMMVVSGNVHGTDERGRLLRRTLMRYANLSSVLILRSISTRVRKRFTTLEDIVEAGFMTTDELRKLNHLYSDFNKYW 182
[Close]
BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Match: best1 (bestrophin 1 [Source:ZFIN;Acc:ZDB-GENE-110411-214])

HSP 1 Score: 87.8113 bits (216), Expect = 2.451e-18
Identity = 56/182 (30.77%), Postives = 96/182 (52.75%), Query Frame = 1 
Query:  460 KHFLFTFNYIQQGVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQ----DTLYNG--MDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAP 987
            K F    + +Q G++T++E   +  +P  H    +P  W +SL + AR+E  + N      I+  +N  +     +   D +S PL+YTQV T+AVY++F+  L   Q       Y G  +D Y+PV ++++F  Y+G LK A  L+NP G D+++FE + ++  N  +     +E+ D  P
Sbjct:  149 KRFPTMSHLVQAGLMTAEELRQLQELPSPHNKFWVPCMWFVSLAMRARSEGRINNDVAMTAILNELNTLRSQCMRLYGYDWISLPLVYTQVVTVAVYSFFLTCLIGRQFLDPAQGYPGHNLDFYLPVFTLLQFFFYVGWLKVAEQLINPFGEDDDDFETNWLVDRNLQVSLLSVDEMYDLVP 330

HSP 2 Score: 82.8037 bits (203), Expect = 1.128e-16
Identity = 48/160 (30.00%), Postives = 86/160 (53.75%), Query Frame = 2 
Query:    2 VHTSRAAIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLNTA--LIMTIIRVHRHKLFVDIASLVKRGLVSISYL 475
            V  +R   F RLL RW+G I KL+  EL IF V++ +++ TYR  L    + +F  +      Y   IP++ +LGF++  V + +  +F+ +PW  ++  L+S H+    +   ++R  ++RY N +  LI   +    +K F  ++ LV+ GL++   L
Sbjct:    9 VADARLGTFYRLLLRWKGSIYKLLYRELLIFTVMYCIISITYRCVLTEEQRRMFEKLSLYCDQYAQLIPVSFVLGFYVTLVVSRWWGQFESVPWPDRLSALVSGHVRGADEGARLIRRSLMRYANLSGILIYRSVSTAVYKRFPTMSHLVQAGLMTAEEL 168
[Close]
BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Match: best2 (bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127])

HSP 1 Score: 85.8853 bits (211), Expect = 5.840e-18
Identity = 54/192 (28.12%), Postives = 101/192 (52.60%), Query Frame = 1 
Query:  460 KHFLFTFNYIQQGVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQ----DTLYNG--MDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDLFFN 1017
            K F    + ++ G +T +E     ++   +    IP  W  +L  +AR E  + + + +  ++E +N ++     +   D +S PL+YTQV TLAVY++F+  L   Q       Y G  +D+Y+P+ ++++F  Y G LK A  L+NP G D+++FE + +I  N+ +     +E+    P  + +D ++N
Sbjct:  151 KRFPTIDHVVEAGFMTREERKKFESLHSPYNKYWIPCVWFTNLAAAARCEGRIKDDNTYKLLLEELNNFRGKCSMLFHYDMISVPLVYTQVVTLAVYSFFLVCLIGRQFLDPGQGYPGHDLDLYVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWLIDRNFQVSMMAVDEMYGDLP-MMERDRYWN 341

HSP 2 Score: 62.003 bits (149), Expect = 3.980e-10
Identity = 44/158 (27.85%), Postives = 79/158 (50.00%), Query Frame = 2 
Query:    2 VHTSRAAIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILG--FFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRY--LNTALIMTIIRVHRHKLFVDIASLVKRGLVS 463
            V  +R   F +LL  W+G I K++  E   F  ++  ++ TYRF L    K  F  +     +Y S IPM+ +LG  F++  V   +  ++  IP   +++ +LS  +  + +R  +LR  ++RY  L+  LI+  +     K F  I  +V+ G ++
Sbjct:    9 VANARFCGFSKLLLAWKGSIYKVLYKEFLAFFAMYTAISITYRFFLVDGQKRYFEKLSIYCDNYASLIPMSFVLGMRFYVTLVVNRWWSQYTSIPLPDRVMCVLSGGVQGSDERGRLLRRTLMRYSSLSALLILRSVSTAVFKRFPTIDHVVEAGFMT 166
[Close]
BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Match: best1 (bestrophin 1 [Source:ZFIN;Acc:ZDB-GENE-110411-214])

HSP 1 Score: 82.8037 bits (203), Expect = 3.031e-17
Identity = 47/144 (32.64%), Postives = 78/144 (54.17%), Query Frame = 1 
Query:  574 WSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQ----DTLYNG--MDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAP 987
            W +SL + AR+E  + N      I+  +N  +     +   D +S PL+YTQV T+AVY++F+  L   Q       Y G  +D Y+PV ++++F  Y+G LK A  L+NP G D+++FE + ++  N  +     +E+ D  P
Sbjct:   27 WFVSLAMRARSEGRINNDVAMTAILNELNTLRSQCMRLYGYDWISLPLVYTQVVTVAVYSFFLTCLIGRQFLDPAQGYPGHNLDFYLPVFTLLQFFFYVGWLKVAEQLINPFGEDDDDFETNWLVDRNLQVSLLSVDEMYDLVP 170
[Close]
BLAST of Bestrophin homolog vs. Ensembl Xenopus
Match: best1 (bestrophin 1 [Source:NCBI gene;Acc:100302038])

HSP 1 Score: 90.1225 bits (222), Expect = 4.914e-37
Identity = 43/125 (34.40%), Postives = 75/125 (60.00%), Query Frame = 2 
Query:    2 VHTSRAAIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLN 376
            V  +R   F RLL RWRG I KL+  E  IF+  +++++ TYRF LN   +I F  +     +Y   IP++ +LGF++  V + +  +++ +PW  +++ L+S ++H T +R  +LR  ++RY N
Sbjct:    9 VADARLGTFSRLLLRWRGSIYKLLYREFLIFISCYFIISVTYRFLLNEQQRIYFEKLALYCDNYAELIPVSFVLGFYVTLVVSRWWGQYESVPWPDRLMCLVSSNVHGTDERGRMLRRTLMRYAN 133

HSP 2 Score: 85.1149 bits (209), Expect = 4.914e-37
Identity = 55/183 (30.05%), Postives = 95/183 (51.91%), Query Frame = 1 
Query:  487 IQQGVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQ----DTLYNG--MDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDLFFN 1017
            +  G +T  E    + +   H    +P  W  +L V+AR+E  + +      I++ +N  +     +   D +S PL+YTQV T+AVY++F+  L   Q       Y G  MD+Y+PV ++++F  Y G LK A  L+NP G D+++FE + +I  N  +     +E+    P  L +D+++N
Sbjct:  158 VNAGFMTPTERSKFDGLVSSHNKFWVPCVWFANLAVTARSEGRIRDNVVLQLILKELNSLRTQCGRLYGYDWISVPLVYTQVVTVAVYSFFLACLIGRQFLDPQKGYPGHDMDLYVPVFTLLQFFFYAGWLKVAEQLINPFGQDDDDFETNWLIDRNLQVSLLAVDEMHQDVPP-LEKDIYWN 339
[Close]
BLAST of Bestrophin homolog vs. Ensembl Xenopus
Match: best1 (bestrophin 1 [Source:NCBI gene;Acc:100302038])

HSP 1 Score: 90.1225 bits (222), Expect = 5.170e-37
Identity = 43/125 (34.40%), Postives = 75/125 (60.00%), Query Frame = 2 
Query:    2 VHTSRAAIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLN 376
            V  +R   F RLL RWRG I KL+  E  IF+  +++++ TYRF LN   +I F  +     +Y   IP++ +LGF++  V + +  +++ +PW  +++ L+S ++H T +R  +LR  ++RY N
Sbjct:    9 VADARLGTFSRLLLRWRGSIYKLLYREFLIFISCYFIISVTYRFLLNEQQRIYFEKLALYCDNYAELIPVSFVLGFYVTLVVSRWWGQYESVPWPDRLMCLVSSNVHGTDERGRMLRRTLMRYAN 133

HSP 2 Score: 84.7297 bits (208), Expect = 5.170e-37
Identity = 55/183 (30.05%), Postives = 95/183 (51.91%), Query Frame = 1 
Query:  487 IQQGVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQ----DTLYNG--MDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDLFFN 1017
            +  G +T  E    + +   H    +P  W  +L V+AR+E  + +      I++ +N  +     +   D +S PL+YTQV T+AVY++F+  L   Q       Y G  MD+Y+PV ++++F  Y G LK A  L+NP G D+++FE + +I  N  +     +E+    P  L +D+++N
Sbjct:  158 VNAGFMTPTERSKFDGLVSSHNKFWVPCVWFANLAVTARSEGRIRDNVVLQLILKELNSLRTQCGRLYGYDWISVPLVYTQVVTVAVYSFFLACLIGRQFLDPQKGYPGHDMDLYVPVFTLLQFFFYAGWLKVAEQLINPFGQDDDDFETNWLIDRNLQVSLLAVDEMHQDVPP-LEKDIYWN 339
[Close]
BLAST of Bestrophin homolog vs. Ensembl Xenopus
Match: best1 (bestrophin 1 [Source:NCBI gene;Acc:100302038])

HSP 1 Score: 90.1225 bits (222), Expect = 5.569e-37
Identity = 43/125 (34.40%), Postives = 75/125 (60.00%), Query Frame = 2 
Query:    2 VHTSRAAIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLN 376
            V  +R   F RLL RWRG I KL+  E  IF+  +++++ TYRF LN   +I F  +     +Y   IP++ +LGF++  V + +  +++ +PW  +++ L+S ++H T +R  +LR  ++RY N
Sbjct:    9 VADARLGTFSRLLLRWRGSIYKLLYREFLIFISCYFIISVTYRFLLNEQQRIYFEKLALYCDNYAELIPVSFVLGFYVTLVVSRWWGQYESVPWPDRLMCLVSSNVHGTDERGRMLRRTLMRYAN 133

HSP 2 Score: 84.7297 bits (208), Expect = 5.569e-37
Identity = 55/183 (30.05%), Postives = 95/183 (51.91%), Query Frame = 1 
Query:  487 IQQGVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQ----DTLYNG--MDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDLFFN 1017
            +  G +T  E    + +   H    +P  W  +L V+AR+E  + +      I++ +N  +     +   D +S PL+YTQV T+AVY++F+  L   Q       Y G  MD+Y+PV ++++F  Y G LK A  L+NP G D+++FE + +I  N  +     +E+    P  L +D+++N
Sbjct:  158 VNAGFMTPTERSKFDGLVSSHNKFWVPCVWFANLAVTARSEGRIRDNVVLQLILKELNSLRTQCGRLYGYDWISVPLVYTQVVTVAVYSFFLACLIGRQFLDPQKGYPGHDMDLYVPVFTLLQFFFYAGWLKVAEQLINPFGQDDDDFETNWLIDRNLQVSLLAVDEMHQDVPP-LEKDIYWN 339
[Close]
BLAST of Bestrophin homolog vs. Ensembl Xenopus
Match: best1 (bestrophin 1 [Source:NCBI gene;Acc:100302038])

HSP 1 Score: 90.1225 bits (222), Expect = 7.238e-37
Identity = 43/125 (34.40%), Postives = 75/125 (60.00%), Query Frame = 2 
Query:    2 VHTSRAAIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLN 376
            V  +R   F RLL RWRG I KL+  E  IF+  +++++ TYRF LN   +I F  +     +Y   IP++ +LGF++  V + +  +++ +PW  +++ L+S ++H T +R  +LR  ++RY N
Sbjct:    9 VADARLGTFSRLLLRWRGSIYKLLYREFLIFISCYFIISVTYRFLLNEQQRIYFEKLALYCDNYAELIPVSFVLGFYVTLVVSRWWGQYESVPWPDRLMCLVSSNVHGTDERGRMLRRTLMRYAN 133

HSP 2 Score: 84.3445 bits (207), Expect = 7.238e-37
Identity = 55/183 (30.05%), Postives = 95/183 (51.91%), Query Frame = 1 
Query:  487 IQQGVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQ----DTLYNG--MDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDLFFN 1017
            +  G +T  E    + +   H    +P  W  +L V+AR+E  + +      I++ +N  +     +   D +S PL+YTQV T+AVY++F+  L   Q       Y G  MD+Y+PV ++++F  Y G LK A  L+NP G D+++FE + +I  N  +     +E+    P  L +D+++N
Sbjct:  158 VNAGFMTPTERSKFDGLVSSHNKFWVPCVWFANLAVTARSEGRIRDNVVLQLILKELNSLRTQCGRLYGYDWISVPLVYTQVVTVAVYSFFLACLIGRQFLDPQKGYPGHDMDLYVPVFTLLQFFFYAGWLKVAEQLINPFGQDDDDFETNWLIDRNLQVSLLAVDEMHQDVPP-LEKDIYWN 339
[Close]
BLAST of Bestrophin homolog vs. Ensembl Xenopus
Match: best1 (bestrophin 1 [Source:NCBI gene;Acc:100302038])

HSP 1 Score: 89.7373 bits (221), Expect = 1.029e-36
Identity = 43/125 (34.40%), Postives = 75/125 (60.00%), Query Frame = 2 
Query:    2 VHTSRAAIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLN 376
            V  +R   F RLL RWRG I KL+  E  IF+  +++++ TYRF LN   +I F  +     +Y   IP++ +LGF++  V + +  +++ +PW  +++ L+S ++H T +R  +LR  ++RY N
Sbjct:    9 VADARLGTFSRLLLRWRGSIYKLLYREFLIFISCYFIISVTYRFLLNEQQRIYFEKLALYCDNYAELIPVSFVLGFYVTLVVSRWWGQYESVPWPDRLMCLVSSNVHGTDERGRMLRRTLMRYAN 133

HSP 2 Score: 84.3445 bits (207), Expect = 1.029e-36
Identity = 55/183 (30.05%), Postives = 95/183 (51.91%), Query Frame = 1 
Query:  487 IQQGVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQ----DTLYNG--MDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDLFFN 1017
            +  G +T  E    + +   H    +P  W  +L V+AR+E  + +      I++ +N  +     +   D +S PL+YTQV T+AVY++F+  L   Q       Y G  MD+Y+PV ++++F  Y G LK A  L+NP G D+++FE + +I  N  +     +E+    P  L +D+++N
Sbjct:  158 VNAGFMTPTERSKFDGLVSSHNKFWVPCVWFANLAVTARSEGRIRDNVVLQLILKELNSLRTQCGRLYGYDWISVPLVYTQVVTVAVYSFFLACLIGRQFLDPQKGYPGHDMDLYVPVFTLLQFFFYAGWLKVAEQLINPFGQDDDDFETNWLIDRNLQVSLLAVDEMHQDVPP-LEKDIYWN 339
[Close]
BLAST of Bestrophin homolog vs. Ensembl Mouse
Match: Best2 (bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588])

HSP 1 Score: 80.4925 bits (197), Expect = 4.540e-16
Identity = 52/193 (26.94%), Postives = 97/193 (50.26%), Query Frame = 1 
Query:  460 KHFLFTFNYIQQGVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFA------SQDTLYNGMDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDLFFNT 1020
            K F    + ++ G +T +E      +   +    +P  W  SL   AR E  + +      ++E +N ++     +   D +S PL+YTQV T+AVY+YF+  L        +Q    + +D+ +P+ ++++F  Y G LK A  L+NP G D+++FE + +I  N+ +     +E+ D     L +DL+++ 
Sbjct:  149 KRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSSLAAQARREGRIRDNSALKLLLEELNVFRSKCGMLFHYDWISIPLVYTQVVTIAVYSYFLACLIGRQFLDPAQGYKDHTLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVDEMYDDL-AMLEKDLYWDA 340

HSP 2 Score: 63.929 bits (154), Expect = 1.165e-10
Identity = 46/156 (29.49%), Postives = 77/156 (49.36%), Query Frame = 2 
Query:    2 VHTSRAAIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRY--LNTALIMTIIRVHRHKLFVDIASLVKRGLVS 463
            V  +R   F +LL  WRG I KL+  EL  FL L+  L+  YRF L    K  F  +V     Y S IP++ +LGF++  V   +  ++  +P    ++ +++  +H    R  + R  ++RY  L+  LI+  +     K F  I  +V+ G ++
Sbjct:    9 VANARFGGFSQLLLLWRGSIYKLLWRELLCFLGLYMALSAAYRFLLAEEQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMPLPDALMCIVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMT 164
[Close]
BLAST of Bestrophin homolog vs. Ensembl Mouse
Match: Best2 (bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588])

HSP 1 Score: 80.4925 bits (197), Expect = 4.540e-16
Identity = 52/193 (26.94%), Postives = 97/193 (50.26%), Query Frame = 1 
Query:  460 KHFLFTFNYIQQGVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFA------SQDTLYNGMDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDLFFNT 1020
            K F    + ++ G +T +E      +   +    +P  W  SL   AR E  + +      ++E +N ++     +   D +S PL+YTQV T+AVY+YF+  L        +Q    + +D+ +P+ ++++F  Y G LK A  L+NP G D+++FE + +I  N+ +     +E+ D     L +DL+++ 
Sbjct:  149 KRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSSLAAQARREGRIRDNSALKLLLEELNVFRSKCGMLFHYDWISIPLVYTQVVTIAVYSYFLACLIGRQFLDPAQGYKDHTLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVDEMYDDL-AMLEKDLYWDA 340

HSP 2 Score: 63.929 bits (154), Expect = 1.165e-10
Identity = 46/156 (29.49%), Postives = 77/156 (49.36%), Query Frame = 2 
Query:    2 VHTSRAAIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRY--LNTALIMTIIRVHRHKLFVDIASLVKRGLVS 463
            V  +R   F +LL  WRG I KL+  EL  FL L+  L+  YRF L    K  F  +V     Y S IP++ +LGF++  V   +  ++  +P    ++ +++  +H    R  + R  ++RY  L+  LI+  +     K F  I  +V+ G ++
Sbjct:    9 VANARFGGFSQLLLLWRGSIYKLLWRELLCFLGLYMALSAAYRFLLAEEQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMPLPDALMCIVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMT 164
[Close]
BLAST of Bestrophin homolog vs. Ensembl Mouse
Match: Best2 (bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588])

HSP 1 Score: 80.4925 bits (197), Expect = 4.540e-16
Identity = 52/193 (26.94%), Postives = 97/193 (50.26%), Query Frame = 1 
Query:  460 KHFLFTFNYIQQGVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFA------SQDTLYNGMDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDLFFNT 1020
            K F    + ++ G +T +E      +   +    +P  W  SL   AR E  + +      ++E +N ++     +   D +S PL+YTQV T+AVY+YF+  L        +Q    + +D+ +P+ ++++F  Y G LK A  L+NP G D+++FE + +I  N+ +     +E+ D     L +DL+++ 
Sbjct:  149 KRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSSLAAQARREGRIRDNSALKLLLEELNVFRSKCGMLFHYDWISIPLVYTQVVTIAVYSYFLACLIGRQFLDPAQGYKDHTLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVDEMYDDL-AMLEKDLYWDA 340

HSP 2 Score: 63.929 bits (154), Expect = 1.165e-10
Identity = 46/156 (29.49%), Postives = 77/156 (49.36%), Query Frame = 2 
Query:    2 VHTSRAAIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRY--LNTALIMTIIRVHRHKLFVDIASLVKRGLVS 463
            V  +R   F +LL  WRG I KL+  EL  FL L+  L+  YRF L    K  F  +V     Y S IP++ +LGF++  V   +  ++  +P    ++ +++  +H    R  + R  ++RY  L+  LI+  +     K F  I  +V+ G ++
Sbjct:    9 VANARFGGFSQLLLLWRGSIYKLLWRELLCFLGLYMALSAAYRFLLAEEQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMPLPDALMCIVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMT 164
[Close]
BLAST of Bestrophin homolog vs. Ensembl Mouse
Match: Best3 (bestrophin 3 [Source:MGI Symbol;Acc:MGI:3580298])

HSP 1 Score: 78.9518 bits (193), Expect = 2.169e-15
Identity = 59/214 (27.57%), Postives = 104/214 (48.60%), Query Frame = 1 
Query:  460 KHFLFTFNYIQQGVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQ----DTLYNG--MDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDLFFNTERVN----FEEVDYGHTSFYG 1071
            K F    + ++ G +T+ E  + + +   H+   +P  W  +L   ARNE  + ++     ++  +N Y+     +   D V  PL+YTQV TLAVY +F   L   Q       Y G  +D+Y+P+ ++++F  Y G LK A  L+NP G D+++FE +  I  N  +     +E+  + P ++ +D++++             DY   SF G
Sbjct:  149 KRFPTMDHVVEAGFMTADERKLFDHLKSPHLKYWVPFIWFGNLATKARNEGRIRDSVDLQSLMTEMNRYRSWCSLLFGYDWVGIPLVYTQVVTLAVYTFFFACLIGRQFLDPTKGYVGHDLDLYVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWCIDRNLQVSLLAVDEMHMSLP-KMKKDIYWDDSAARPPYTLAAADYCIPSFLG 361

HSP 2 Score: 73.1738 bits (178), Expect = 1.368e-13
Identity = 44/150 (29.33%), Postives = 78/150 (52.00%), Query Frame = 2 
Query:   26 FLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLN--TALIMTIIRVHRHKLFVDIASLVKRGLVSIS 469
            F RLL +WRG I KL+  E  +F VL+  ++  YR  L G  K  F  +      Y  +IP+  +LGF++  V   +  +F  +PW  +++ L+S  +H + +   +LR  ++RY+N  + LI   +    +K F  +  +V+ G ++  
Sbjct:   17 FHRLLLKWRGSIYKLLYREFIVFAVLYTAISLVYRLLLTGAQKRYFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFVNLPWPDRLMLLISSSVHGSDQHGRLLRRTLMRYVNLTSLLIFRSVSTAVYKRFPTMDHVVEAGFMTAD 166
[Close]
BLAST of Bestrophin homolog vs. Ensembl Mouse
Match: Best1 (bestrophin 1 [Source:MGI Symbol;Acc:MGI:1346332])

HSP 1 Score: 73.1738 bits (178), Expect = 1.006e-13
Identity = 38/84 (45.24%), Postives = 56/84 (66.67%), Query Frame = 1 
Query:  697 DQVSFPLIYTQVNTLAVYAYFMFSLFASQ----DTLYNG--MDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVI 930
            D +S PL+YTQV T+AVY++F+  L   Q    +  Y G  MD+ +PV +I++FL YMG LK A  L+NP G D+++FE + +I
Sbjct:  228 DWISIPLVYTQVVTVAVYSFFLACLIGRQFLNPNKDYPGHEMDLVVPVFTILQFLFYMGWLKVAEQLINPFGEDDDDFETNWII 311

HSP 2 Score: 68.5514 bits (166), Expect = 3.305e-12
Identity = 43/156 (27.56%), Postives = 79/156 (50.64%), Query Frame = 2 
Query:    2 VHTSRAAIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRY--LNTALIMTIIRVHRHKLFVDIASLVKRGLVS 463
            V  +R   F  LL  WRG I KL+  E  +F+ L+Y +   YR  L+ + +++F  +      Y   IP++ +LGF++  V + +  +++ +PW  +++  +S  +    +   +LR  +IRY  L   LI+  I    +K F  +  LV  G ++
Sbjct:    9 VANARLGSFSSLLLCWRGSIYKLLYGEFLVFIFLYYSIRGLYRMVLSSDQQLLFEKLALYCDSYIQLIPISFVLGFYVTLVVSRWWSQYENLPWPDRLMIQVSSFVEGKDEEGRLLRRTLIRYAILGQVLILRSISTSVYKRFPTLHHLVLAGFMT 164
[Close]
BLAST of Bestrophin homolog vs. UniProt/SwissProt
Match: sp|P34672|BST24_CAEEL (Bestrophin homolog 24 OS=Caenorhabditis elegans OX=6239 GN=best-24 PE=3 SV=1)

HSP 1 Score: 85.1149 bits (209), Expect = 3.758e-31
Identity = 57/197 (28.93%), Postives = 100/197 (50.76%), Query Frame = 1 
Query:  451 RFSKHFLFTFNYIQQGVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQDTL------YNGMDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDLFFNTE 1023
            R  + F      +  G +   E D  + I Y +    +P  W+ SL   AR + L+ + +  V + + I +++  L  I   D V  P++Y Q+  LAV+ YF+  L A Q  +         +D+Y P+ S ++F+ YMG +K A  +LNP G D+++FE + +I  N  +   + ++  D AP+ L +D F++ E
Sbjct:  146 RTRRRFPTLDTVVAAGFMMPHEKDRFDEIQYKYSKYWVPFQWAFSLTYEARKKGLIESDYYQVVVQDEIKKFRTGLAWICNYDWVPIPIMYPQLVCLAVHTYFLVCLLARQYVVSEHADNKTEIDLYFPIMSTLQFIFYMGWMKVAEAMLNPFGEDDDDFECNALIDRNITMVLMMVDQGYDRAPD-LKRDDFWDEE 341

HSP 2 Score: 72.0182 bits (175), Expect = 3.758e-31
Identity = 42/130 (32.31%), Postives = 74/130 (56.92%), Query Frame = 2 
Query:    2 VHTSRAAIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLNTALIM 391
            V TS+     +LL +WRG I K VI+EL ++LVL+ +L+  YR ALN   +  F  IV+      S IP+  +LGFF+ +V   +   +++I +I  I  + + ++   +++  + R +I+RY   A ++
Sbjct:    9 VSTSKPWTLFKLLLKWRGSIWKAVILELAVWLVLYGILSVIYRTALNPGQQRTFERIVQYCDSRLSYIPLNFMLGFFVTAVVNRWTYLYQIIGFIDNIGLMAAEYVRGRTEQARMYRRNIVRYCELAQVL 138
[Close]
BLAST of Bestrophin homolog vs. UniProt/SwissProt
Match: sp|Q23369|BST22_CAEEL (Bestrophin homolog 22 OS=Caenorhabditis elegans OX=6239 GN=best-22 PE=3 SV=1)

HSP 1 Score: 88.9669 bits (219), Expect = 1.032e-30
Identity = 52/159 (32.70%), Postives = 91/159 (57.23%), Query Frame = 1 
Query:  496 GVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQDTLY----NGMDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCI 960
            G++T +E D+++ I   +      I WS++LV   + +  + + +    IV+ I +++  L  ++  D V  PL+Y QV  LAV  YFM  L   Q  +     +G+D+++P+ ++V+FLVYMG +K A  LLNP+G D+++ E + +I  N + G  I
Sbjct:  162 GLMTHEEMDILDHIKDPYSRYWTSIQWSLNLVYECQKKGKVDSYYLMNKIVDEIGKFRHGLASLLKYDWVPVPLVYPQVIFLAVRIYFMICLIGRQFIVTGPNPSGIDLWLPITTMVQFLVYMGWMKVAEALLNPLGEDDDDLECNYIIDKNLITGLSI 320

HSP 2 Score: 67.0106 bits (162), Expect = 1.032e-30
Identity = 41/150 (27.33%), Postives = 80/150 (53.33%), Query Frame = 2 
Query:   26 FLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQ--SKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRY--LNTALIMTIIRVHRHKLFVDIASLVKRGLVS 463
            F  LL RWRG + K V  +L ++  +F +++  YR+ L+ + + +F  +++  FD +  + IP+  +LGFF+  V A +      I WI     L + ++    +   ++R +++RY  L+ AL++  I +   K F  + +L   GL++
Sbjct:   17 FFSLLLRWRGSVWKAVFGQLAVWTAVFLLISCIYRYMLSPSQQDVFEQLIR-YFDNKLDANIPLTFLLGFFVSFVVARWGSILNGIGWIDDASLLFATYIRGADEETRVIRRNLVRYLVLSQALVLRDISMQVRKRFPTMDTLAASGLMT 165
[Close]
BLAST of Bestrophin homolog vs. UniProt/SwissProt
Match: sp|P34577|BST18_CAEEL (Bestrophin homolog 18 OS=Caenorhabditis elegans OX=6239 GN=best-18 PE=3 SV=2)

HSP 1 Score: 82.8037 bits (203), Expect = 3.064e-29
Identity = 53/170 (31.18%), Postives = 84/170 (49.41%), Query Frame = 1 
Query:  574 WSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQ-----DTLYNGMDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDLFFNTERVNFEEVDYGHTSFY 1068
            W+ +LV +AR E L+   +    I E I +++  L  +   D V  P+IY  +  LAV+ YF   + A Q     +   + +D+  P  + ++F+ YMG LK   GLLNP G D ++FE + +I  N  +G  I +E  D  P +L +D F++   V        H   Y
Sbjct:  187 WAWALVYNARKEGLIEGDYYVTVISEDIKKFRTGLAWVCNYDWVPLPIIYPTIVCLAVHMYFFVGILARQYVKGSEIDPDMIDLVFPFMTSIQFVFYMGWLKVGEGLLNPWGEDPDDFETNMLIDRNLAMGLKIVDEGYDKTP-RLEKDAFWDDTWVPLYSEASAHEKRY 355

HSP 2 Score: 67.781 bits (164), Expect = 3.064e-29
Identity = 46/155 (29.68%), Postives = 79/155 (50.97%), Query Frame = 2 
Query:    2 VHTSRAAIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRY--LNTALIMTIIRVHRHKLFVDIASLVKRGLV 460
            V TSR   FL L+ RWRG +   + ++  ++L L+++++  YRF L+   + IF+ +V  V    S +P+  +LGFFI  V   F   + +I +I  I    + ++   S+R    R +IIRY  L   LI   + +   K F  + ++   G +
Sbjct:    9 VATSRPWTFLALIFRWRGSVWSAIWIQYSVWLGLYFLVSAIYRFILSAYQQQIFVRLVDYVNSRMSYVPLDWMLGFFIAGVLRRFWYLYDIIGFIDNIACSTATYIRGDSERAKQYRRNIIRYCELTQVLIFRDLSMKARKRFPTLDTVAAAGFM 163
[Close]
BLAST of Bestrophin homolog vs. UniProt/SwissProt
Match: sp|Q22566|BST17_CAEEL (Bestrophin homolog 17 OS=Caenorhabditis elegans OX=6239 GN=best-17 PE=3 SV=2)

HSP 1 Score: 75.485 bits (184), Expect = 1.058e-28
Identity = 44/159 (27.67%), Postives = 84/159 (52.83%), Query Frame = 2 
Query:    2 VHTSRAAIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLNTALIMTIIRVHRHKLFVDIASLVKRGLVSISYLL 478
            V +    +FLRLL RWRG I K V+ +L ++L+ +Y + F YR+A +   + +F +I     D    +P+  +LGFF+ +V+  +     ++P+I  +   ++  L    + + + R  IIRY         + +H+  +F DI+  V+R   ++ Y++
Sbjct:   31 VSSGNPLLFLRLLGRWRGSIWKSVVGDLFVWLLFYYAIYFAYRYAFSKQLQTVFEEISIHTDDRMKYLPLTFMLGFFVTTVFERWRSALNVMPFIESVALSVAVLLPGKGREDRLTRRAIIRY---------VVLHQILVFRDISMRVRRRFPTLKYVV 180

HSP 2 Score: 73.559 bits (179), Expect = 1.058e-28
Identity = 46/151 (30.46%), Postives = 80/151 (52.98%), Query Frame = 1 
Query:  574 WSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQDTLYN-----GMDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDLF 1011
            W+ SL + A  ++L+     F  ++ AI E++  +  +I  D +  P+ Y QV  LAV  YF   L + Q  + +      MD  +P+ +++EF+  +G +K A  LLNP+G D+++FE++ +I  N   G  I +      P+ L  D+F
Sbjct:  210 WANSLALVAHQQKLIDQPTAFNNVIFAIKEFRVAMETLIKFDAIPIPIAYPQVVFLAVRVYFAICLVSRQFLISDMKSKTQMDWPVPIMTVLEFIFVIGWMKVAEVLLNPLGEDDDDFEVNSIIDNNISRGMAIVDTTHGYHPD-LVDDVF 359
[Close]
BLAST of Bestrophin homolog vs. UniProt/SwissProt
Match: sp|P34319|BEST5_CAEEL (Bestrophin homolog 5 OS=Caenorhabditis elegans OX=6239 GN=best-5 PE=3 SV=2)

HSP 1 Score: 88.5817 bits (218), Expect = 5.247e-27
Identity = 52/173 (30.06%), Postives = 92/173 (53.18%), Query Frame = 1 
Query:  490 QQGVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQ----DTLYNG--MDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPE 990
            Q G++   E +  N+I   +    +  +W++ L+  A+ E+ +   +    I + I++++  L  + + D V  PL+Y Q+  +AV+ YF   +F  Q       +N   +D+YIP  +I+EF+ YMG LK A+ LLNP G D ++F+ + +I  N  IG    ++  D  PE
Sbjct:  202 QAGIMLPHELEKFNSIKSRYQKYWVSFNWALELLNVAKTEKSIDGDNARNAIAQEISKFRSALTTVSMYDWVPIPLMYPQLVNMAVHTYFFLCIFTRQFFISADAHNKTEVDLYIPFMTIIEFIFYMGWLKVAMELLNPFGEDADDFDCNLLIDRNLAIGLTSVDDAYDQLPE 374

HSP 2 Score: 54.6842 bits (130), Expect = 5.247e-27
Identity = 37/153 (24.18%), Postives = 79/153 (51.63%), Query Frame = 2 
Query:    8 TSRAAIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRY--LNTALIMTIIRVHRHKLFVDIASLVKRGLV 460
            TS++ + +R++ +WRG + + V  EL +++  + +++  YRFAL  + K IF    +        +P+  +LGFF   +   +++ +  +  I  I   +S ++  T  R   +R +IIRY  ++  L+   I V   + F  + ++ + G++
Sbjct:   54 TSKSLMIVRMIFKWRGSLWQAVYKELIVWICAYSLVSVIYRFALTRSQKDIFERFGEYCDARMGYLPLNFVLGFFCNIIIRRWLKLYTSLGNIDNIALFVSAYVRGTDDRARQIRRNIIRYCVISQCLVFRDIHVGVRRRFPTLEAVAQAGIM 206
[Close]
BLAST of Bestrophin homolog vs. TrEMBL
Match: A0A4S2KY96 (Bestrophin homolog OS=Opisthorchis felineus OX=147828 GN=CRM22_010477 PE=3 SV=1)

HSP 1 Score: 116.701 bits (291), Expect = 5.333e-47
Identity = 64/195 (32.82%), Postives = 104/195 (53.33%), Query Frame = 1 
Query:  484 YIQQGVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQDTL-------YNGMDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDLFFNTERVNFEEVD 1047
            ++  GV T +E  +++ +          I W+ SL+  A  E+++TN H  VF++  +N  ++ L  +   D V  PL+YTQV TL+VY+YF+ SL   Q  +        N  D Y P  + +E ++Y+G LK A  L+NPMG D+E+ +I+EVI +NW    CI +  V  +P  + +D  +N   V     +
Sbjct:  157 FVTAGVFTEEETKLLDGMELHFQPFAPII-WTTSLITLAEKEKIITNEHALVFLIAEVNNLRQGLLNVFFMDYVCVPLVYTQVVTLSVYSYFIASLIGRQYIMSSSTMRDQNNHDFYFPFFTTLELIIYVGWLKVAETLVNPMGEDDEDIDINEVIDFNWKAAWCIVDG-VKPSPPAVVRDAHWNQTVVELPHTE 349

HSP 2 Score: 101.293 bits (251), Expect = 5.333e-47
Identity = 53/152 (34.87%), Postives = 93/152 (61.18%), Query Frame = 2 
Query:    8 TSRAAIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLNTALIMTIIRVH--RHKLFVDIASLVKRGL 457
            T    +FLRLL +WRG + KL+ +++ +FL L++ ++  YRFAL    +  F  ++  +  +Q+ IP+A ILGF++  ++A F  +F +IPW++KI   L+ HL  + +R  +LR   +RYL  +LI+T  RV+    + F ++ + V  G+
Sbjct:   11 TGGPGVFLRLLLKWRGCVFKLIYVDILVFLGLYFSISLIYRFALTEPLQRNFESLILFINRFQAMIPVAFILGFYVALIFARFWHQFMVIPWVLKIAVGLTAHLPGSDERPRLLRRTCMRYLMGSLILTCTRVNLVAKRRFPNLDAFVTAGV 162
[Close]
BLAST of Bestrophin homolog vs. TrEMBL
Match: A0A4Z2DHZ0 (Bestrophin homolog OS=Schistosoma japonicum OX=6182 GN=EWB00_000802 PE=3 SV=1)

HSP 1 Score: 124.405 bits (311), Expect = 1.406e-46
Identity = 70/188 (37.23%), Postives = 116/188 (61.70%), Query Frame = 1 
Query:  448 KRFSKHFLFTFNYIQQGVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQ----DTLYNGM----DMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAP 987
            KRF    +F    +  G+LT +E+ +I  +  +H+ P +P+ W+ SL+  AR E L+ N H +V +V+ +N +++ +  +++ D V  PL+YTQV TL+VY+YF+ SL +SQ     + + G     D+  P  +I+E  VY+G LK A  L+NPMG D+E+ +I+E+I +NW I  C+ + V  +AP
Sbjct:  149 KRFPSFEIF----VASGILTEEESRIIRNVQSIHMQPFVPVVWASSLISLARKEGLIQNQHAYVLLVQELNNFRQKILNVMMMDTVCIPLVYTQVVTLSVYSYFVASLVSSQFIVSSSPFVGKAGSYDLIFPFFTILELFVYVGWLKVAETLVNPMGEDDEDIDINEIIDFNWKISWCVVDGVRTSAP 332

HSP 2 Score: 92.4337 bits (228), Expect = 1.406e-46
Identity = 45/122 (36.89%), Postives = 74/122 (60.66%), Query Frame = 2 
Query:    8 TSRAAIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYL 373
            T    IF RLL +WRGG++KL+  +L IF  ++ +++  YRF ++ N + +F  ++     +Q+ IP+A ILGF++  V+A F   F MIPW+M     L  HL  T++R  ++R   +RY+
Sbjct:   11 TGGPGIFFRLLLKWRGGVIKLICPDLIIFATIYTLISCLYRFVISENAQRLFERLILFTSKFQAMIPVAFILGFYVALVFARFWNYFTMIPWVMSFALNLVTHLPGTAERNRLIRRTCMRYI 132
[Close]
BLAST of Bestrophin homolog vs. TrEMBL
Match: A0A4S2LQZ2 (Bestrophin homolog OS=Opisthorchis felineus OX=147828 GN=CRM22_005782 PE=3 SV=1)

HSP 1 Score: 116.701 bits (291), Expect = 4.194e-46
Identity = 66/208 (31.73%), Postives = 107/208 (51.44%), Query Frame = 1 
Query:  484 YIQQGVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQDTLYN--------GMDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDLFFNTERVNF----EEVDYGHTSFYG 1071
            +I  G+ T +E  M+  +          + W++SL+  A  E+L+TN H  V +++ +N +++ L  I   D V  PL+YTQV TL+VY+Y + SL   Q  + N          D Y P  +++E ++Y+G LK A  LLNPMG D+E+ ++D +I  NW    CI +  + T+P  + +D  +    V      E    G T + G
Sbjct:  157 FIAAGLFTDEEVQMLEGMQIHFQPFAPVM-WAVSLLTMAEKEQLITNPHALVLLIQDVNSFRQGLLNIFFMDYVCVPLVYTQVVTLSVYSYLVASLIGRQYIMNNSPLIDNTTSKDFYFPFFTLLELVIYVGWLKVAETLLNPMGEDDEDLDVDSIINSNWRTAWCIVDG-MKTSPPAVLRDAHWAEAIVELPHTEESKKLGSTPYRG 362

HSP 2 Score: 98.5969 bits (244), Expect = 4.194e-46
Identity = 51/152 (33.55%), Postives = 93/152 (61.18%), Query Frame = 2 
Query:    8 TSRAAIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLNTALIMTIIRVHR--HKLFVDIASLVKRGL 457
            T    +F++L  RWRG + KL+ +++ +FL L++ ++  YRFAL  + +  F  +V  + ++QS IP++ ILGF++  +++ F  ++ +IPWI K+   L+ HL  + +R+ ++R   +RYL  +LI+T  RV+    K F D  + +  GL
Sbjct:   11 TGGPCVFVQLFLRWRGCVFKLIYVDIIVFLTLYFTISLIYRFALPEDTQRGFERLVLFIHNFQSMIPVSFILGFYVSLIFSRFWHQYVVIPWITKLSMGLTTHLPGSGERQRMIRRACVRYLLGSLILTFTRVNLTIKKRFPDFEAFIAAGL 162
[Close]
BLAST of Bestrophin homolog vs. TrEMBL
Match: A0A3Q0KJ57 (Bestrophin homolog OS=Schistosoma mansoni OX=6183 PE=3 SV=1)

HSP 1 Score: 119.013 bits (297), Expect = 4.738e-44
Identity = 70/188 (37.23%), Postives = 113/188 (60.11%), Query Frame = 1 
Query:  448 KRFSKHFLFTFNYIQQGVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQDT--------LYNGMDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAP 987
            KRF    LF    +  G+LT  EA +I ++  +H+ P +P+ W+ SL+  AR E L+ N H +V +V  +N +++ +  +++ D V  PL+YTQV TL+VY+YF+ SL +SQ          +    D++ P  + +E  VY+G LK A  L+NPMG D+E+ +I+E+I +NW I  C+ + V  +AP
Sbjct:  149 KRFPTFELF----VASGILTEDEARIIRSVQSVHMQPFVPVVWATSLITLARKEGLIKNPHAYVLLVNELNTFRQKILYVMMMDDVCIPLVYTQVVTLSVYSYFVASLISSQFIISSSPFAGIARSHDVFFPFFTFLELFVYVGWLKVAETLVNPMGEDDEDIDINEIIDFNWRISWCVVDGVRTSAP 332

HSP 2 Score: 89.3521 bits (220), Expect = 4.738e-44
Identity = 46/129 (35.66%), Postives = 76/129 (58.91%), Query Frame = 2 
Query:    8 TSRAAIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLNTALIMT 394
            T    IF RLL +WRGG++KL+ ++L IF  ++ +++  YRF +  N +  F  ++     +Q+ IP+A ILGF++  V+A F   F  IPW+M     L  HL  +++R  ++R   +RY+   LI+T
Sbjct:   11 TGGPGIFFRLLLKWRGGVLKLISLDLIIFASIYILISCLYRFVITENAQRNFERLILFTSKFQAMIPVAFILGFYVALVFARFWNYFTTIPWVMSFALTLVTHLPGSAERNRLIRRTCMRYIMANLIIT 139
[Close]
BLAST of Bestrophin homolog vs. TrEMBL
Match: A0A3Q0KJ43 (Bestrophin homolog OS=Schistosoma mansoni OX=6183 PE=3 SV=1)

HSP 1 Score: 127.102 bits (318), Expect = 2.923e-42
Identity = 69/172 (40.12%), Postives = 104/172 (60.47%), Query Frame = 1 
Query:  484 YIQQGVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQ----DTLYNGMDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAP 987
            ++  G+LT +E D+++  P      +  + W+ SLV  A  E  +TN H  V I++ IN +++ L ++ + D V  PL+YTQV TLAVY YF+ SL   Q     +  N  D+Y P    +EF+VYMGLLK A  L+NPMG ++E+ +I+EVI +NW  G CI + +  +AP
Sbjct:  118 FVAAGILTEEELDIMSVSPIHVQPFVPVV-WTTSLVTLAGKEGFITNHHALVSIIDEINNFRQGLLDMFMIDFVCIPLVYTQVVTLAVYIYFIASLVGRQFIIDSSRTNSQDLYFPFFMFLEFIVYMGLLKVAETLVNPMGENDEDIDINEVIDFNWKTGWCIVDGMKTSAP 288

HSP 2 Score: 75.0998 bits (183), Expect = 2.923e-42
Identity = 37/105 (35.24%), Postives = 63/105 (60.00%), Query Frame = 2 
Query:   95 LVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLNTALIMTIIRVH 409
            + L+ ++   YRFAL+  ++  F DI+     +Q  IP++ ILGF+I +V+  F R F  IPW++K    +S HL   S+R  ++R    RY+ ++L+MT  R++
Sbjct:    1 MALYALITCVYRFALSAEWQRTFEDIIIFTRSFQGLIPVSFILGFYIDNVFTRFWRLFMTIPWVLKFAISISGHLSGNSERARLMRRTCFRYMMSSLVMTSTRLN 105
[Close]
BLAST of Bestrophin homolog vs. Ensembl Cavefish
Match: best2 (bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127])

HSP 1 Score: 85.8853 bits (211), Expect = 7.452e-18
Identity = 54/192 (28.12%), Postives = 102/192 (53.12%), Query Frame = 1 
Query:  460 KHFLFTFNYIQQGVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQ----DTLYNG--MDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDLFFN 1017
            K F    + ++ G +T +E     ++   +    IP  W  +L   AR+E  + + + +  ++E +N+++     +   D +S PL+YTQV TLAVY++F+  L   Q       Y G  +D+Y+P+ ++++F  Y G LK A  L+NP G D+++FE + +I  N+ +     +E+    P  + +D ++N
Sbjct:  149 KRFPTMDHVVEAGFMTREERKKFESLHSPYNKYWIPCVWFTNLAAVARSEGRIKDDNTYKLLLEELNKFRGKCSLLFHYDMISVPLVYTQVVTLAVYSFFLVCLIGRQFLDPSQAYPGHDLDLYVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWLIDRNFQVSMMAVDEMFGDLP-MMERDRYWN 339

HSP 2 Score: 64.6994 bits (156), Expect = 5.863e-11
Identity = 46/156 (29.49%), Postives = 78/156 (50.00%), Query Frame = 2 
Query:    2 VHTSRAAIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLNTA--LIMTIIRVHRHKLFVDIASLVKRGLVS 463
            V  +R   F +LL  WRG I K++  E+  F +L+  ++ TYRF L    K  F  +      Y S IPM+ +LGF++  +   +  ++  IP    I+ +LS  L    +R  +LR  ++RY + A  LI+  +     K F  +  +V+ G ++
Sbjct:    9 VANARFCGFSKLLLAWRGSIYKVLYKEVLAFFILYTAISITYRFFLLDEQKRYFEKLSIYCNHYASLIPMSFVLGFYVTLIVNRWWSQYTSIPLPDSIMCVLSGGLQGGDERGRLLRRTLMRYASLASLLILRSVSTAVFKRFPTMDHVVEAGFMT 164
[Close]
BLAST of Bestrophin homolog vs. Ensembl Cavefish
Match: best1 (bestrophin-2 [Source:NCBI gene;Acc:103045999])

HSP 1 Score: 85.1149 bits (209), Expect = 1.600e-17
Identity = 55/182 (30.22%), Postives = 97/182 (53.30%), Query Frame = 1 
Query:  460 KHFLFTFNYIQQGVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQ----DTLYNG--MDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAP 987
            K F    + +Q G++T +E   ++ +P  H    +P  W ++L + AR E  + N      I+  +N  +    ++   D +S PL+YTQV T+AVY++F+  L   Q       Y+G  +D Y+PV ++++F  Y+G LK A  L+NP G D+++FE + ++  N  +     +E+ D  P
Sbjct:  149 KRFPTIEHLVQAGLMTVEERRQLDDLPSPHNKFWVPCMWFVNLALRARTEGRINNDVALSAILNELNTLRSQCMKLYSYDWISLPLVYTQVVTVAVYSFFLACLIGRQFLDPTQGYSGHDLDFYLPVFTLLQFFFYVGWLKVAEQLINPFGEDDDDFETNWLVDRNLQVSLLSVDEMYDLVP 330

HSP 2 Score: 79.337 bits (194), Expect = 1.287e-15
Identity = 47/158 (29.75%), Postives = 83/158 (52.53%), Query Frame = 2 
Query:    2 VHTSRAAIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLNTA--LIMTIIRVHRHKLFVDIASLVKRGLVSIS 469
            V  +R   F  LL RW+G I KL+  EL IF VL+  ++  YRF L+   + +F  +      Y   IP++ +LGF++  V + +  +F+ +PW  ++  L+  ++    +   ++R  ++RY N +  LI   I    +K F  I  LV+ GL+++ 
Sbjct:    9 VADARLGTFSHLLLRWKGSIYKLLYRELLIFTVLYCTISVLYRFLLDNEQRRLFEKLAIYCDQYAQLIPVSFVLGFYVTLVVSRWWGQFESVPWPDRLAALVGAYVRGADEGARLIRRSLVRYANLSGVLIYRSISTAVYKRFPTIEHLVQAGLMTVE 166
[Close]
BLAST of Bestrophin homolog vs. Ensembl Cavefish
Match: best4 (bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6])

HSP 1 Score: 80.8777 bits (198), Expect = 1.620e-16
Identity = 52/172 (30.23%), Postives = 88/172 (51.16%), Query Frame = 1 
Query:  448 KRFSKHFLFTFNYIQQGVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQ-VNTLAVYAYFMFSLFASQ-------DTLYNGMDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYN 939
            KRF      T  +I    +T +E   ++ +        +P++W  +L   AR E  + +      +++ +N Y+     +   D +S PL+YTQ V TLAVY++F F L   Q       D L   +D+Y+PV +++EF  Y G LK    ++NP G D+++FE +++I  N
Sbjct:  148 KRFP-----TLQHIVDAFMTEEEMRTLDHLYSDFNKYWMPLTWFANLASKAREEGRVKDDIALRLLMDELNNYRGKCSMLFHYDWISIPLVYTQQVVTLAVYSFFAFCLIGRQFVKPERADELKVHVDLYVPVFTLLEFFFYAGWLKVGELIINPFGEDDDDFETNQLIDRN 314
[Close]
BLAST of Bestrophin homolog vs. Ensembl Cavefish
Match: best1 (bestrophin-2 [Source:NCBI gene;Acc:103045999])

HSP 1 Score: 78.9518 bits (193), Expect = 1.470e-15
Identity = 47/158 (29.75%), Postives = 83/158 (52.53%), Query Frame = 2 
Query:    2 VHTSRAAIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLNTA--LIMTIIRVHRHKLFVDIASLVKRGLVSIS 469
            V  +R   F  LL RW+G I KL+  EL IF VL+  ++  YRF L+   + +F  +      Y   IP++ +LGF++  V + +  +F+ +PW  ++  L+  ++    +   ++R  ++RY N +  LI   I    +K F  I  LV+ GL+++ 
Sbjct:    9 VADARLGTFSHLLLRWKGSIYKLLYRELLIFTVLYCTISVLYRFLLDNEQRRLFEKLAIYCDQYAQLIPVSFVLGFYVTLVVSRWWGQFESVPWPDRLAALVGAYVRGADEGARLIRRSLVRYANLSGVLIYRSISTAVYKRFPTIEHLVQAGLMTVE 166

HSP 2 Score: 55.0694 bits (131), Expect = 6.878e-8
Identity = 46/182 (25.27%), Postives = 83/182 (45.60%), Query Frame = 1 
Query:  460 KHFLFTFNYIQQGVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQ----DTLYNG--MDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAP 987
            K F    + +Q G++T +E   ++ +P  H    +P  W ++L + AR E  + N      I+  +                          T+AVY++F+  L   Q       Y+G  +D Y+PV ++++F  Y+G LK A  L+NP G D+++FE + ++  N  +     +E+ D  P
Sbjct:  149 KRFPTIEHLVQAGLMTVEERRQLDDLPSPHNKFWVPCMWFVNLALRARTEGRINNDVALSAILNVV--------------------------TVAVYSFFLACLIGRQFLDPTQGYSGHDLDFYLPVFTLLQFFFYVGWLKVAEQLINPFGEDDDDFETNWLVDRNLQVSLLSVDEMYDLVP 304
[Close]
BLAST of Bestrophin homolog vs. Ensembl Cavefish
Match: BEST3 (bestrophin 3 [Source:HGNC Symbol;Acc:HGNC:17105])

HSP 1 Score: 77.0258 bits (188), Expect = 4.936e-15
Identity = 60/202 (29.70%), Postives = 99/202 (49.01%), Query Frame = 1 
Query:  496 GVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQ--DTL--YNG--MDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDLFFNTERVNFE----EVDYGHTSFYG 1071
            G +T +E  +   +   H+   IP  W  +L   AR +  + ++     I+  +N ++     +   D V  PL+YTQV TLAVY +F  S+   Q  D    Y G  +D+Y+PV ++++F  Y G LK A  L+NP G D+++FE +  I  N  +     +E+    P ++ +D+++N   V         DY   SF G
Sbjct:   83 GFMTPEEKKIFENLKSPHLKYWIPTVWFTNLASKARKDGRIQDSVDLQTILTEMNRFRTWCSTLFGYDWVGIPLVYTQVVTLAVYTFFSASIIGRQFLDPAQGYPGHDLDLYVPVFTLLQFFFYSGWLKVAEQLINPFGEDDDDFEANWCIDRNLQVSLMAVDEMHMNIP-RMTKDVYWNDPDVRPPYTRAAADYCIPSFLG 283
[Close]
BLAST of Bestrophin homolog vs. Ensembl Sea Lamprey
Match: best1 (bestrophin 1 [Source:ZFIN;Acc:ZDB-GENE-110411-214])

HSP 1 Score: 88.5817 bits (218), Expect = 8.826e-20
Identity = 48/158 (30.38%), Postives = 88/158 (55.70%), Query Frame = 2 
Query:    2 VHTSRAAIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLNTA--LIMTIIRVHRHKLFVDIASLVKRGLVSIS 469
            V  +R   F +LL RW+G I KL+  E  IFLVLF+ L+  YR+ L  N K  F  +      Y   IP++ +LGF++  V + +  +++ +PW  +++ L++ ++H   +R  +LR  ++RY N +  LI+  +    +K F  +  +V+ G ++ +
Sbjct:    9 VANARLGGFSQLLLRWKGSIYKLLYKEFCIFLVLFFTLSSVYRYMLQENQKRYFEKLAMYCNKYAELIPVSFVLGFYVTLVVSRWWSQYESLPWPDRLMHLVACNVHGADERGRLLRRTLMRYANLSALLILRSVSTAVYKRFPTMDHVVEAGFMTPA 166

HSP 2 Score: 78.5666 bits (192), Expect = 1.833e-16
Identity = 54/188 (28.72%), Postives = 93/188 (49.47%), Query Frame = 1 
Query:  460 KHFLFTFNYIQQGVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQ---DTLYNG--MDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDL 1008
            K F    + ++ G +T  E    + +   H    +P  W  +L   A+ E  + +      I+  +N ++     +   D VS PL+YTQV T+AVY++F+  L   Q      Y G  MD+YIPV ++++F  Y G LK A  L+NP G D+++FE       NW +   +   ++    +++++DL
Sbjct:  149 KRFPTMDHVVEAGFMTPAERRKFDGLRSPHNKFWVPCVWFANLAAQAKAEGRILDNVSLQLILNDLNNFRSCCSMLYSYDWVSIPLVYTQVVTVAVYSFFLACLIGRQFLGPQGYPGHDMDLYIPVFTLLQFFFYAGWLKVAEQLINPFGEDDDDFEA------NWCVDRNLQVSLMGV--DEMYRDL 328
[Close]
BLAST of Bestrophin homolog vs. Ensembl Sea Lamprey
Match: best2 (bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127])

HSP 1 Score: 86.6557 bits (213), Expect = 7.553e-19
Identity = 58/194 (29.90%), Postives = 98/194 (50.52%), Query Frame = 1 
Query:  460 KHFLFTFNYIQQGVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQ----DTLYNG--MDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDLFFNTE 1023
            K F    + ++ G +T  E    + +   +    +P  W  SL   AR E  + +      +++ +N Y+ N   +   D +S PL+YTQV T+AVY++F+  L   Q       Y G  MD+YIPV ++++F  Y G LK A  L+NP G D+++FE + +I  N  +     +E+    P  L +D+++N  
Sbjct:  149 KRFPTMDHVVEAGFMTRDERKRFDGLRCSYNKYWVPCVWLSSLAAQARAEGRVRDDVALKLLLDEMNVYRGNCGMLFHYDWISVPLVYTQVVTVAVYSFFLACLIGRQFLDPAQGYPGHDMDLYIPVFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNLQVSMLAVDEMYQNLP-LLQRDMYWNAS 341

HSP 2 Score: 70.8626 bits (172), Expect = 1.260e-13
Identity = 42/156 (26.92%), Postives = 83/156 (53.21%), Query Frame = 2 
Query:    2 VHTSRAAIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLNTA--LIMTIIRVHRHKLFVDIASLVKRGLVS 463
            V  +R   F +LL +WRG I KL+  E  I+ +++  L+ T RFAL+ + K +F  +     +Y + IP+    GF++  V + +  ++  IP   +++  ++  +H   +R  +LR  ++RY N +  LI+  +    +K F  +  +V+ G ++
Sbjct:    9 VANARLCGFSKLLLQWRGSIYKLLYREFSIYFMMYAALSLTSRFALSEDQKRLFEKLSLYCNNYANLIPVRSCSGFYVALVVSRWWSQYTSIPTPDRLMCAVAGTVHGVDERGRLLRRTLMRYANLSALLILRSVSTAVYKRFPTMDHVVEAGFMT 164
[Close]
BLAST of Bestrophin homolog vs. Ensembl Medaka
Match: best2 (bestrophin 2 [Source:NCBI gene;Acc:110015962])

HSP 1 Score: 87.0409 bits (214), Expect = 2.991e-18
Identity = 54/182 (29.67%), Postives = 92/182 (50.55%), Query Frame = 1 
Query:  460 KHFLFTFNYIQQGVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQ----DTLYNG--MDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAP 987
            K F    + ++ G +T +E      +   +    IP  W  +L   AR E  + + H    ++E +N ++     +   D VS PL+YTQV TLAVY++F+  L   Q       Y G  +D+Y+P+ ++++F  Y G LK A  L+NP G D+++FE + +I  N+ +     +E+    P
Sbjct:  149 KRFPTMDHVVEAGFMTREERKKFEGLHSPYNKYWIPCVWFTNLAAVARCEGRIRDDHALKLLLEELNAFRGKCSLLFHYDMVSVPLVYTQVVTLAVYSFFLVCLIGRQFLDPSQGYQGHDLDLYVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWLIDRNFQVSMMAVDEMYGDLP 330

HSP 2 Score: 68.1662 bits (165), Expect = 5.284e-12
Identity = 46/156 (29.49%), Postives = 79/156 (50.64%), Query Frame = 2 
Query:    2 VHTSRAAIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRY--LNTALIMTIIRVHRHKLFVDIASLVKRGLVS 463
            V  +R   F +LL  W+G I K++  E   F VL+  ++ TYRF L  + K  F  +      Y S IPM+ +LGF++  +   +  ++  IP   +I+ +LS  L    +R  +LR  ++RY  L+  LI+  +     K F  +  +V+ G ++
Sbjct:    9 VANARFCGFSKLLLAWKGSIYKVLYKEFLAFFVLYAAISITYRFFLYEDQKRYFEKLAIYCNHYASLIPMSFVLGFYVTLIVNRWWNQYTSIPLPDRIMCVLSGGLQGNDERGRLLRRSMMRYASLSALLILRSVSTAVFKRFPTMDHVVEAGFMT 164
[Close]
BLAST of Bestrophin homolog vs. Ensembl Medaka
Match: best1 (bestrophin-2 [Source:NCBI gene;Acc:101167866])

HSP 1 Score: 85.8853 bits (211), Expect = 1.001e-17
Identity = 60/196 (30.61%), Postives = 104/196 (53.06%), Query Frame = 1 
Query:  448 KRFSKHFLFTFNYIQQGVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQ----DTLYNG--MDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDLFFN 1017
            KRF      T  ++ Q ++TS+E      +P  H    +P  W ++L + AR E  + N      I+  +N  +    ++   D +S PL+YTQV T+AVY++F+  L   Q       Y G  +D Y+PV ++++F  Y+G LK A  L+NP G D+++FE + V+  N  +     +E+ D+ P  + +D+++N
Sbjct:  147 KRFP-----TTEHLVQALMTSEELRHFEELPSPHNKFWVPCMWFVNLALRARTEGRINNDVALTAILTELNSLRAKCMKLYGYDWISLPLVYTQVATVAVYSFFLACLIGRQFLDPAQGYPGHDVDFYLPVFTLLQFFFYVGWLKVAEQLINPFGEDDDDFETNWVVDRNLQVSLLSVDEMYDSLP-LVEKDVYWN 336

HSP 2 Score: 61.6178 bits (148), Expect = 6.668e-10
Identity = 42/145 (28.97%), Postives = 75/145 (51.72%), Query Frame = 2 
Query:   20 AIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLNTA--LIMTIIRVHRHKLFVDIASLVK 448
              F  LL RW+G I KL+  EL IF +L+Y L+  Y + L+ + + +F  +      Y   IP++ +L F++  V + +  +F+ IPW  ++  L+  H+  T +   + R  ++RY+N +  LI   +    +K F     LV+
Sbjct:   15 GTFFHLLLRWKGSIYKLLYRELIIFTLLYYFLSLVY-YMLDNDQRRLFERLSIYCDRYAELIPVSFVL-FYVTLVVSRWWGQFENIPWPDRLAALVGGHVRGTDEASRLTRRALMRYVNLSGVLIYRSVSTAVYKRFPTTEHLVQ 157
[Close]
BLAST of Bestrophin homolog vs. Ensembl Medaka
Match: BEST3 (bestrophin 3 [Source:NCBI gene;Acc:101172121])

HSP 1 Score: 74.3294 bits (181), Expect = 4.479e-14
Identity = 59/214 (27.57%), Postives = 101/214 (47.20%), Query Frame = 1 
Query:  460 KHFLFTFNYIQQGVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFA------SQDTLYNGMDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDLFFNTERVN----FEEVDYGHTSFYG 1071
            K F    + ++ G +T +E  +   I   H+   IP+ W  +L   AR E  + +      I+  +N ++     +   D V  PL+YTQV TLAVY +F   +        +Q    + +D+Y+PV ++++F  Y G LK A  L+NP G D+++FE + +I  N  +     +E+    P  + +D+++N             DY   SF G
Sbjct:  149 KRFPTIDHVVEAGFMTPEERKVFENIRSPHLKYWIPVVWFSNLASRARQEGRIQDAIDLQNILNEMNTFRTWCATLFGYDWVGIPLVYTQVVTLAVYTFFFACIIGRQFLDPAQGHPGHDLDLYVPVFTLLQFFFYSGWLKVAEQLINPFGEDDDDFEANWIIDRNLQVSLLAVDEMHMNLP-HMTKDIYWNDSDARPPYTLAAADYCIPSFLG 361

HSP 2 Score: 68.1662 bits (165), Expect = 4.222e-12
Identity = 44/148 (29.73%), Postives = 77/148 (52.03%), Query Frame = 2 
Query:   26 FLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLN--TALIMTIIRVHRHKLFVDIASLVKRGLVS 463
            F RLL RWRG I KL+  E  +F +L+ +L+  YR AL+   K +F  +      Y  +IP+  +LGF++  V   +  +F  +PW  +++  +S  +    +   +LR  ++RY+N  + LI   +     K F  I  +V+ G ++
Sbjct:   17 FHRLLLRWRGSIYKLLYREFLLFALLYTILSLIYRLALSEQQKRLFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFLNLPWPDRLMFHISSCVQGKDEYGRLLRRTLVRYINLTSLLIFRSVSTAVCKRFPTIDHVVEAGFMT 164
[Close]
BLAST of Bestrophin homolog vs. Planmine SMEST
Match: SMESG000023666.1 (SMESG000023666.1)

HSP 1 Score: 372.474 bits (955), Expect = 1.469e-128
Identity = 196/209 (93.78%), Postives = 201/209 (96.17%), Query Frame = 1 
Query:  451 RFSKHFLFT--FNYIQQGVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQDTLYNGMDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDLFFNTERVNFEEVDYGHTSFYG 1071
            R  +H LF    + +++GVLTSKEADMINAIPYLHIHPLIPISWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQDTLYNGMDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDLFFNTERVNFEEVDYGHTSFYG
Sbjct:  109 RVHRHKLFVDIASLVKRGVLTSKEADMINAIPYLHIHPLIPISWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQDTLYNGMDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDLFFNTERVNFEEVDYGHTSFYG 317

HSP 2 Score: 253.062 bits (645), Expect = 8.705e-82
Identity = 126/129 (97.67%), Postives = 129/129 (100.00%), Query Frame = 2 
Query:   77 MELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLNTALIMTIIRVHRHKLFVDIASLVKRGLVS 463
            MELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLNTALIMTIIRVHRHKLFVDIASLVKRG+++
Sbjct:    1 MELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLNTALIMTIIRVHRHKLFVDIASLVKRGVLT 129
[Close]
BLAST of Bestrophin homolog vs. Planmine SMEST
Match: SMESG000030918.1 (SMESG000030918.1)

HSP 1 Score: 118.242 bits (295), Expect = 8.341e-48
Identity = 71/183 (38.80%), Postives = 116/183 (63.39%), Query Frame = 1 
Query:  493 QGVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQ---DT--LYNGMDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEV-VDTAPEQLFQDLFFNTE 1023
            +G+L   EA++I       + P +PI+WS ++V+ A  +  +TN    +  V+ IN++++ L E+ L DQV  PL+YTQV TLAVY+YF+  L   Q   D+  +    D  +P+ +I++F+VYMG LK A+ L+NPMG D+E+F+++ V+ YN+ IG  I++ V +D  P  L +D FF+ +
Sbjct:  174 KGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQDFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPP--LIKDKFFDKK 354

HSP 2 Score: 91.6633 bits (226), Expect = 8.341e-48
Identity = 56/161 (34.78%), Postives = 90/161 (55.90%), Query Frame = 2 
Query:   26 FLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTS-------------KRETIL-RSHIIRYLNTALIMTIIRVH--RHKLFVDIASLVKRGLV 460
            FL+LL +W+GG+ KL+ M+  +F  L+ +++  YR  L   +K  F  +V  V+  QS IP+A ILGF++  V+  F R F  +PWI KI  +++ H+++ S             K E  L R  IIRYL  +LI+T+ RV     + F +I  +  +G++
Sbjct:   17 FLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGIL 177
[Close]
BLAST of Bestrophin homolog vs. Planmine SMEST
Match: SMESG000054993.1 (SMESG000054993.1)

HSP 1 Score: 116.316 bits (290), Expect = 2.231e-45
Identity = 78/219 (35.62%), Postives = 127/219 (57.99%), Query Frame = 1 
Query:  487 IQQGVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQDTLYNGMDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDLFFNTERVNFEEVDYGHTS---FYG*QKILNTDTK*MYSKIQILQN 1134
            I+ G+LT  E  ++N     +    +P  W+ +LV  A +E++     G   ++E I +++ +L  I   D ++ PL+YTQ+ T++V+AYFM  +FA Q    + +D+Y+P+   ++F+ YMG LK A  L+NP G+D+++FEIDE+I  N  + + I +E+ D+ PE L +D+F+N+ R      DY       F G    LNTD   + SKI I QN
Sbjct:  158 IENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDKVDVYVPMFGFLQFVFYMGWLKVAESLINPFGDDDDDFEIDEMIHRNIKMSYLIIDEMHDSYPE-LDKDVFWNSNRDIQIIHDYKSPKNDMFAGSLLNLNTDESFLGSKINIFQN 375

HSP 2 Score: 85.5001 bits (210), Expect = 2.231e-45
Identity = 50/156 (32.05%), Postives = 81/156 (51.92%), Query Frame = 2 
Query:    2 VHTSRAAIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLNTALIMTI--IRVHRHKLFVDIASLVKRGLVS 463
            V TS+   FLRLL RW+G I K++  E+ +F  L+  L+  YRF L G YK  F +           IP+  +LGF++  V + +  +F  IPW   +   +S  +     +  + R  I+RYLN +  MT   I     ++F D+ +L++ GL++
Sbjct:    9 VATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLT 164
[Close]
BLAST of Bestrophin homolog vs. Planmine SMEST
Match: SMESG000057100.1 (SMESG000057100.1)

HSP 1 Score: 81.6481 bits (200), Expect = 1.698e-31
Identity = 47/151 (31.13%), Postives = 88/151 (58.28%), Query Frame = 1 
Query:  574 WSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQDTLYNGMDMYI-PVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDLFFNTE 1023
            W+ +L+  AR + L+ +      +VE +  ++  L ++ ++  +S PL+YTQV T+ VY YF+ +L A Q    +G D YI P   +++FL Y+G LK A  LL+P G  +++F++  +I  N  + + I +++    PE + +D+++  E
Sbjct:  190 WAANLIRDARRKNLIKDDRQLDVLVETLTSFRGILCDLFVHQWISPPLVYTQVATITVYCYFLAALMAWQ--FISGKDDYIFPFFGMLQFLFYVGWLKVAENLLDPFGEKDDDFDMTFLIERNVQMAYLIVDDMHRDIPE-IKKDVYWKDE 337

HSP 2 Score: 73.9442 bits (180), Expect = 1.698e-31
Identity = 47/152 (30.92%), Postives = 81/152 (53.29%), Query Frame = 2 
Query:   35 LLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFAL---NGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLNTALIMTIIRVHRH--KLFVDIASLVKRGLVSISYL 475
            +L RW+G + KLV  E  IF  ++  L+  YRF L   +   + +F  + +   +  ++IP+A +LGF++  V   +  +FK +PW   I   LS  L   +    +LR  I+RY+N  +I+    + +   KLF  + S+ K GL+++S L
Sbjct:   20 ILLRWKGSVFKLVRFEALIFFSIYGSLSLIYRFVLVPYHTKSEFVFSFMCQYCIEIMNRIPVAFVLGFYVSIVINWWSEQFKSLPWPDDIALQLSAFLQGETDEIVLLRRTIVRYVNMGMIIAFRGISKSTLKLFSTLESMKKAGLMNMSEL 171
[Close]
BLAST of Bestrophin homolog vs. Planmine SMEST
Match: SMESG000069980.1 (SMESG000069980.1)

HSP 1 Score: 108.612 bits (270), Expect = 2.374e-26
Identity = 60/182 (32.97%), Postives = 106/182 (58.24%), Query Frame = 1 
Query:  487 IQQGVLTSKEADMINAXXXXXXXXXXXXSWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQDTLY------NGMDMYIPVRSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDLFF 1014
            ++QG+LT++E   +           +PI+W+  LVV A+ E+ L +      +   +NE++  L  +   D ++ PLIYTQ+  + +Y+YF+FS+F  Q  ++      +GM++Y+PV   +EF+ YMG LK A  L+NP G+DE++FE+D++IL N+       ++     P  L QD+++
Sbjct:  157 VEQGLLTTEELSRLEKFETTSNKHFVPIAWAQELVVKAQKEKYLMDNKRVWLLANELNEFRDRLRILFAYDWINPPLIYTQIAIITMYSYFIFSIFGKQFIIHGTSQSAHGMNLYVPVFGALEFINYMGWLKVAQCLINPFGDDEDDFEMDQIILRNFEYSFITVDQWHQQCPP-LQQDMYY 337

HSP 2 Score: 56.9954 bits (136), Expect = 7.603e-9
Identity = 40/160 (25.00%), Postives = 79/160 (49.38%), Query Frame = 2 
Query:    2 VHTSRAAIFLRLLCRWRGGIVKLVIMELGIFLVLFYVLNFTYRFALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRY--LNTALIMTIIRVHRHKLFVDIASLVKRGLVSISYL 475
            + TS +    +LL  W+G I K + +EL I++VL  +++  + F L G Y++IF             IP+ ++LGF++  V   +  +F  +PW   +   ++  +        ++R  I+RY  ++  L  + I     ++F    +LV++GL++   L
Sbjct:    9 IATSNSFRVFKLLLTWKGSIYKTIRIELFIYIVLNALISLLHYF-LTGYYRLIFESFCSFCAKGTGFIPVGLVLGFYVTLVVQRWTDQFVTLPWPDSLAVYVNTFILGAGDTPRLIRRSIMRYVIVSQILCYSSISSKAKRVFSTNQTLVEQGLLTTEEL 167
The following BLAST results are available for this feature:
BLAST of Bestrophin homolog vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
BEST34.172e-1728.50bestrophin 3 [Source:HGNC Symbol;Acc:HGNC:17105][more]
BEST11.159e-1629.75bestrophin 1 [Source:HGNC Symbol;Acc:HGNC:12703][more]
BEST11.159e-1629.75bestrophin 1 [Source:HGNC Symbol;Acc:HGNC:12703][more]
BEST32.243e-1628.50bestrophin 3 [Source:HGNC Symbol;Acc:HGNC:17105][more]
BEST13.513e-1629.75bestrophin 1 [Source:HGNC Symbol;Acc:HGNC:12703][more]
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BLAST of Bestrophin homolog vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
best-226.082e-3430.77Bestrophin homolog 22 [Source:UniProtKB/Swiss-Pro... [more]
best-226.996e-3430.77Bestrophin homolog 22 [Source:UniProtKB/Swiss-Pro... [more]
best-243.692e-3228.93Bestrophin homolog 24 [Source:UniProtKB/Swiss-Pro... [more]
best-226.767e-3232.70Bestrophin homolog 22 [Source:UniProtKB/Swiss-Pro... [more]
best-227.111e-3232.70Bestrophin homolog 22 [Source:UniProtKB/Swiss-Pro... [more]
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BLAST of Bestrophin homolog vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Best33.848e-3332.26gene:FBgn0036492 transcript:FBtr0075618[more]
Best12.421e-2234.50gene:FBgn0040238 transcript:FBtr0337020[more]
Best12.582e-2234.50gene:FBgn0040238 transcript:FBtr0306023[more]
Best13.182e-2234.50gene:FBgn0040238 transcript:FBtr0082183[more]
Best13.495e-2234.50gene:FBgn0040238 transcript:FBtr0114590[more]
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BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
best44.948e-1929.94bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6][more]
best45.485e-1929.94bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6][more]
best12.451e-1830.77bestrophin 1 [Source:ZFIN;Acc:ZDB-GENE-110411-214][more]
best25.840e-1828.13bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127][more]
best13.031e-1732.64bestrophin 1 [Source:ZFIN;Acc:ZDB-GENE-110411-214][more]
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BLAST of Bestrophin homolog vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
best14.914e-3734.40bestrophin 1 [Source:NCBI gene;Acc:100302038][more]
best15.170e-3734.40bestrophin 1 [Source:NCBI gene;Acc:100302038][more]
best15.569e-3734.40bestrophin 1 [Source:NCBI gene;Acc:100302038][more]
best17.238e-3734.40bestrophin 1 [Source:NCBI gene;Acc:100302038][more]
best11.029e-3634.40bestrophin 1 [Source:NCBI gene;Acc:100302038][more]
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BLAST of Bestrophin homolog vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Best24.540e-1626.94bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588][more]
Best24.540e-1626.94bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588][more]
Best24.540e-1626.94bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588][more]
Best32.169e-1527.57bestrophin 3 [Source:MGI Symbol;Acc:MGI:3580298][more]
Best11.006e-1345.24bestrophin 1 [Source:MGI Symbol;Acc:MGI:1346332][more]
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BLAST of Bestrophin homolog vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P34672|BST24_CAEEL3.758e-3128.93Bestrophin homolog 24 OS=Caenorhabditis elegans OX... [more]
sp|Q23369|BST22_CAEEL1.032e-3032.70Bestrophin homolog 22 OS=Caenorhabditis elegans OX... [more]
sp|P34577|BST18_CAEEL3.064e-2931.18Bestrophin homolog 18 OS=Caenorhabditis elegans OX... [more]
sp|Q22566|BST17_CAEEL1.058e-2827.67Bestrophin homolog 17 OS=Caenorhabditis elegans OX... [more]
sp|P34319|BEST5_CAEEL5.247e-2730.06Bestrophin homolog 5 OS=Caenorhabditis elegans OX=... [more]
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BLAST of Bestrophin homolog vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A4S2KY965.333e-4732.82Bestrophin homolog OS=Opisthorchis felineus OX=147... [more]
A0A4Z2DHZ01.406e-4637.23Bestrophin homolog OS=Schistosoma japonicum OX=618... [more]
A0A4S2LQZ24.194e-4631.73Bestrophin homolog OS=Opisthorchis felineus OX=147... [more]
A0A3Q0KJ574.738e-4437.23Bestrophin homolog OS=Schistosoma mansoni OX=6183 ... [more]
A0A3Q0KJ432.923e-4240.12Bestrophin homolog OS=Schistosoma mansoni OX=6183 ... [more]
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BLAST of Bestrophin homolog vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
best27.452e-1828.13bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127][more]
best11.600e-1730.22bestrophin-2 [Source:NCBI gene;Acc:103045999][more]
best41.620e-1630.23bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6][more]
best11.470e-1529.75bestrophin-2 [Source:NCBI gene;Acc:103045999][more]
BEST34.936e-1529.70bestrophin 3 [Source:HGNC Symbol;Acc:HGNC:17105][more]
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BLAST of Bestrophin homolog vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
best18.826e-2030.38bestrophin 1 [Source:ZFIN;Acc:ZDB-GENE-110411-214][more]
best27.553e-1929.90bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127][more]
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BLAST of Bestrophin homolog vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Bestrophin homolog vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Bestrophin homolog vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 3
Match NameE-valueIdentityDescription
best22.991e-1829.67bestrophin 2 [Source:NCBI gene;Acc:110015962][more]
best11.001e-1730.61bestrophin-2 [Source:NCBI gene;Acc:101167866][more]
BEST34.479e-1427.57bestrophin 3 [Source:NCBI gene;Acc:101172121][more]
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BLAST of Bestrophin homolog vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000023666.11.469e-12893.78SMESG000023666.1[more]
SMESG000030918.18.341e-4838.80SMESG000030918.1[more]
SMESG000054993.12.231e-4535.62SMESG000054993.1[more]
SMESG000057100.11.698e-3131.13SMESG000057100.1[more]
SMESG000069980.12.374e-2632.97SMESG000069980.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30032556 ID=SMED30032556|Name=Bestrophin homolog|organism=Schmidtea mediterranea sexual|type=transcript|length=1143bp
CGTGCATACGAGTCGAGCTGCTATTTTTCTCCGATTATTGTGCAGATGGA
GAGGGGGAATTGTTAAATTAGTTATAATGGAGTTGGGAATATTTTTAGTT
TTATTCTATGTGTTAAATTTTACATACCGATTTGCATTGAATGGCAATTA
CAAAATAATATTTATGGATATTGTTAAAACCGTATTCGACTATCAATCTA
AAATTCCCATGGCAATCATTTTGGGATTTTTCATTGTATCAGTGTATGCA
AATTTTATACGCCGATTCAAAATGATACCGTGGATCATGAAGATCATTAC
TTTGTTATCGTTTCATTTGCATAGCACGAGTAAACGCGAAACCATTCTTC
GAAGTCATATAATAAGGTATCTGAATACCGCTCTAATCATGACAATCATC
CGTGTCCATAGGCACAAACTGTTTGTCGACATTGCTAGTTTAGTTAAAAG
AGGTTTAGTAAGCATTTCTTATTTACTTTTAATTATATTCAACAAGGTGT
ATTGACATCGAAAGAGGCTGATATGATAAACGCCATTCCATATTTGCATA
TTCATCCGCTTATTCCGATTTCCTGGTCAATTTCATTAGTAGTAAGTGCT
CGAAATGAGGAACTGCTTACTAATACTCATGGCTTTGTATTCATTGTTGA
GGCTATTAATGAATATAAACGCAATTTATTTGAAATTATTCTCAACGACC
AAGTGTCCTTTCCACTCATTTATACTCAAGTCAATACTCTTGCAGTTTAT
GCTTATTTCATGTTTTCATTATTTGCATCCCAAGATACATTGTACAACGG
TATGGATATGTATATCCCTGTTAGATCTATTGTAGAATTTCTTGTTTATA
TGGGCCTGCTGAAATGCGCAATAGGATTGCTAAATCCAATGGGAAATGAT
GAAGAGAATTTTGAAATAGACGAAGTGATTTTGTATAATTGGATGATAGG
ACATTGCATCAGCAACGAAGTTGTAGACACAGCTCCTGAGCAACTTTTTC
AAGATTTATTCTTTAACACAGAACGAGTTAATTTTGAAGAAGTCGATTAC
GGACACACATCTTTCTACGGATAACAGAAAATTTTAAACACAGATACAAA
ATAAATGTATTCCAAAATACAGATATTACAAAATTTTAATCAT
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protein sequence of SMED30032556-orf-1

>SMED30032556-orf-1 ID=SMED30032556-orf-1|Name=SMED30032556-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=184bp
MINAIPYLHIHPLIPISWSISLVVSARNEELLTNTHGFVFIVEAINEYKR
NLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQDTLYNGMDMYIPV
RSIVEFLVYMGLLKCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEV
VDTAPEQLFQDLFFNTERVNFEEVDYGHTSFYG*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: INTERPRO
TermDefinition
IPR000615Bestrophin
IPR021134Bestrophin/UPF0187
Vocabulary: molecular function
TermDefinition
GO:0005254chloride channel activity
Vocabulary: cellular component
TermDefinition
GO:0005886plasma membrane
GO:0016020membrane
GO:0016021integral component of membrane
GO:0034707chloride channel complex
Vocabulary: biological process
TermDefinition
GO:0006810transport
GO:0006811ion transport
GO:0006821chloride transport
GO:1902476chloride transmembrane transport
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR021134Bestrophin/UPF0187PFAMPF01062Bestrophincoord: 12..136
e-value: 5.2E-25
score: 88.4
IPR000615BestrophinPANTHERPTHR10736BESTROPHINcoord: 11..170
NoneNo IPR availableTMHMMTMhelixcoord: 63..85
NoneNo IPR availableTMHMMTMhelixcoord: 98..120