NPHP8
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30032498 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 18Note: Hover over icons to view figure legend
Homology
BLAST of NPHP8 vs. Ensembl Human
Match: RPGRIP1L (RPGRIP1 like [Source:HGNC Symbol;Acc:HGNC:29168]) HSP 1 Score: 538.88 bits (1387), Expect = 2.503e-168 Identity = 340/913 (37.24%), Postives = 531/913 (58.16%), Query Frame = 3
Query: 177 RKTISQWTKDYLEDKYLRLQDDHETLKKHARLQEXXXXXXXXXXXXXXSDAKKNGDIT--PK--------TDDFEEFRRKCSILESQNGLLKDKVKLLQSQLLAQGKKASVYDNVPSRIKSGAIERSNSIQNSGRKNNIR-VIKPRGELYPLSPRRDESVTGDQSLISLNKVVEDLK--YEVHRLQIEN----EELLKKAYRREDEKL----------SPEHYKSNLKDNLDMIRVTRDIKEKEIQVNVLHGKYEDLKTKQQYLERNNREMSDEIERLTSRLRSTDDFAGNAEGQIRNVTVLRKRINDLEATNNDFKKEIYLLKESNDKLTNDAFNTERERDWREKEMNYRAKIAQLELTLKRDVSEKGGVLNKLESERDRVDNAEKEMSNLRLRNYELQAQIEELSDKLKFFSKEASLNPQEIEEALMIIQHKRNMVHAQSTPELDFIQKIDKNKDQDLTRKLLECEMNHAETIQELEKTRSLLRTQYKISNDYRQESEKISQRLDEIKKDYEERLTEYARLLDIRAARIHKLEAQLKDIAYGTRNTQIETILEPD--LEPLAPEI-LERGENILEIHIGRVCLTQQAVENIKDKDPFLFGTWDFYDFETQATGVLRGTSSEFDIKAEYLVKIDDFFLNYLYKNTFPFELHQATGAEYVTLAACQMSCKDIXXXXXXXXXXXXXXXNGLKYHCRAKLVGLRENSKDI-NFGVLEYWIRLKHPMDQVIRQYREKLKAEGYIMGN-----EMSVVEARRP-------IDS----MNELIIRIIRCKGLKSRQKHLQPSPYIAYKFYDHSHHTSVTIPSSNSPEFHDLRRIPVQMNSDLHQYLKLQNLQIYVLDELDPDESVYLGVATIPLIQLCHNKNISGSFELHDNQHASNGTLEVELTWQHSYMYQDNSFT 2774
R+ +S+ +++ LED++LRL D++ LK+HAR QE KIK++ TKL+++ +D K+ + PK + E+ + K LE QN LK+++ + QL QG + + Y+NV SRI +G R + +N+G + R IK + +P + G+ L + +L+ + R QIE E+LK RR++ ++ +SN++DN++MI++ + + EK ++ + GK+ L+ KQ+ L ++ + + L +L+ + E Q+ ++ +RI +L+ ND +KE LLKE+ DKL + AF+ E W+ KE + +IAQLE LK D+++K +L++L++ERD+ + +E L+L+ E + Q++EL ++K +++E +N E+ EAL++I+ ++ Q +L F+ K+D ++DL R + E + HAET+QELEKTR++L Q+KI+ DY+ E E ++++++ +++DYE ++ +Y LLDIRAARIHKLEAQLKDIAYGT+ + + + PD ++ I LERGEN+ EIHI +V + + ++ DK+P F T+ FYDFE Q T V+RG E++ ++YLV ++D FL Y+ KNT E+HQA EY T+AACQ+ +I EKS + C A L+G + DI NFG +EYW RL+ PMDQ IR YRE+ KA GYI N M + + P DS +NEL I I C L+SR HLQP PY+ YKF+D + H + IPSSN P+F D PV MN DL +YLK ++L YV D+ D E++Y+G +PLI L H++ ISG FEL D+Q GT+ V L W+ +Y+ S T
Sbjct: 39 RQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTG---RRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKE----QKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHLERGENLFEIHINKVTFSSEVLQASGDKEPVTFCTYAFYDFELQTTPVVRGLHPEYNFTSQYLVHVNDLFLQYIQKNTITLEVHQAYSTEYETIAACQLKFHEILEKSG-------------RIFCTASLIGTK---GDIPNFGTVEYWFRLRVPMDQAIRLYRERAKALGYITSNFKGPEHMQSLSQQAPKTAQLSSTDSTDGNLNELHITIRCCNHLQSRASHLQPHPYVVYKFFDFADHDTAIIPSSNDPQFDDHMYFPVPMNMDLDRYLKSESLSFYVFDDSDTQENIYIGKVNVPLISLAHDRCISGIFELTDHQKHPAGTIHVILKWKFAYLPPSGSIT 928 HSP 2 Score: 57.7658 bits (138), Expect = 1.699e-7 Identity = 41/131 (31.30%), Postives = 69/131 (52.67%), Query Frame = 3
Query: 3513 DEIVVEISSVEIADSADLLTDNNIKFIYVEYRLPGISLESTETISLQKPSVNQEIKKMNYNFKKTFDVSFNKNYMIRQHIATMLT--EEPNKYIVFTLVQEPTADSE-ADCEDIGTAKVNVKTLLKESRNL 3896
++I +EI ++ + DS + D+ I+ ++VE R + E T +SL KP Q + YN+ V N R + +L E PN+ + FT+V +P D + +CEDIG A V++ + +E R+L
Sbjct: 1101 EKIRIEIIALSLNDS-QVTMDDTIQRLFVECRFYSLPAEET-PVSLPKPKSGQWVY---YNYSNVIYVDKENNKAKRDILKAILQKQEMPNRSLRFTVVSDPPEDEQDLECEDIGVAHVDLADMFQEGRDL 1226
BLAST of NPHP8 vs. Ensembl Human
Match: RPGRIP1L (RPGRIP1 like [Source:HGNC Symbol;Acc:HGNC:29168]) HSP 1 Score: 538.495 bits (1386), Expect = 5.312e-168 Identity = 340/913 (37.24%), Postives = 531/913 (58.16%), Query Frame = 3
Query: 177 RKTISQWTKDYLEDKYLRLQDDHETLKKHARLQEXXXXXXXXXXXXXXSDAKKNGDIT--PK--------TDDFEEFRRKCSILESQNGLLKDKVKLLQSQLLAQGKKASVYDNVPSRIKSGAIERSNSIQNSGRKNNIR-VIKPRGELYPLSPRRDESVTGDQSLISLNKVVEDLK--YEVHRLQIEN----EELLKKAYRREDEKL----------SPEHYKSNLKDNLDMIRVTRDIKEKEIQVNVLHGKYEDLKTKQQYLERNNREMSDEIERLTSRLRSTDDFAGNAEGQIRNVTVLRKRINDLEATNNDFKKEIYLLKESNDKLTNDAFNTERERDWREKEMNYRAKIAQLELTLKRDVSEKGGVLNKLESERDRVDNAEKEMSNLRLRNYELQAQIEELSDKLKFFSKEASLNPQEIEEALMIIQHKRNMVHAQSTPELDFIQKIDKNKDQDLTRKLLECEMNHAETIQELEKTRSLLRTQYKISNDYRQESEKISQRLDEIKKDYEERLTEYARLLDIRAARIHKLEAQLKDIAYGTRNTQIETILEPD--LEPLAPEI-LERGENILEIHIGRVCLTQQAVENIKDKDPFLFGTWDFYDFETQATGVLRGTSSEFDIKAEYLVKIDDFFLNYLYKNTFPFELHQATGAEYVTLAACQMSCKDIXXXXXXXXXXXXXXXNGLKYHCRAKLVGLRENSKDI-NFGVLEYWIRLKHPMDQVIRQYREKLKAEGYIMGN-----EMSVVEARRP-------IDS----MNELIIRIIRCKGLKSRQKHLQPSPYIAYKFYDHSHHTSVTIPSSNSPEFHDLRRIPVQMNSDLHQYLKLQNLQIYVLDELDPDESVYLGVATIPLIQLCHNKNISGSFELHDNQHASNGTLEVELTWQHSYMYQDNSFT 2774
R+ +S+ +++ LED++LRL D++ LK+HAR QE KIK++ TKL+++ +D K+ + PK + E+ + K LE QN LK+++ + QL QG + + Y+NV SRI +G R + +N+G + R IK + +P + G+ L + +L+ + R QIE E+LK RR++ ++ +SN++DN++MI++ + + EK ++ + GK+ L+ KQ+ L ++ + + L +L+ + E Q+ ++ +RI +L+ ND +KE LLKE+ DKL + AF+ E W+ KE + +IAQLE LK D+++K +L++L++ERD+ + +E L+L+ E + Q++EL ++K +++E +N E+ EAL++I+ ++ Q +L F+ K+D ++DL R + E + HAET+QELEKTR++L Q+KI+ DY+ E E ++++++ +++DYE ++ +Y LLDIRAARIHKLEAQLKDIAYGT+ + + + PD ++ I LERGEN+ EIHI +V + + ++ DK+P F T+ FYDFE Q T V+RG E++ ++YLV ++D FL Y+ KNT E+HQA EY T+AACQ+ +I EKS + C A L+G + DI NFG +EYW RL+ PMDQ IR YRE+ KA GYI N M + + P DS +NEL I I C L+SR HLQP PY+ YKF+D + H + IPSSN P+F D PV MN DL +YLK ++L YV D+ D E++Y+G +PLI L H++ ISG FEL D+Q GT+ V L W+ +Y+ S T
Sbjct: 39 RQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTG---RRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKE----QKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHLERGENLFEIHINKVTFSSEVLQASGDKEPVTFCTYAFYDFELQTTPVVRGLHPEYNFTSQYLVHVNDLFLQYIQKNTITLEVHQAYSTEYETIAACQLKFHEILEKSG-------------RIFCTASLIGTK---GDIPNFGTVEYWFRLRVPMDQAIRLYRERAKALGYITSNFKGPEHMQSLSQQAPKTAQLSSTDSTDGNLNELHITIRCCNHLQSRASHLQPHPYVVYKFFDFADHDTAIIPSSNDPQFDDHMYFPVPMNMDLDRYLKSESLSFYVFDDSDTQENIYIGKVNVPLISLAHDRCISGIFELTDHQKHPAGTIHVILKWKFAYLPPSGSIT 928 HSP 2 Score: 59.6918 bits (143), Expect = 4.085e-8 Identity = 42/139 (30.22%), Postives = 73/139 (52.52%), Query Frame = 3
Query: 3513 DEIVVEISSVEIADSADLLTDNNIKFIYVEYRLPGISLESTETISLQKPSVNQEIKKMNYNFKKTFDVSFNKNYMIRQHIATMLT--EEPNKYIVFTLVQEPTADSE-ADCEDIGTAKVNVKTLLKESRNLENERIPIY 3920
++I +EI ++ + DS + D+ I+ ++VE R + E T +SL KP Q + YN+ V N R + +L E PN+ + FT+V +P D + +CEDIG A V++ + +E R+L + I ++
Sbjct: 1101 EKIRIEIIALSLNDS-QVTMDDTIQRLFVECRFYSLPAEET-PVSLPKPKSGQWVY---YNYSNVIYVDKENNKAKRDILKAILQKQEMPNRSLRFTVVSDPPEDEQDLECEDIGVAHVDLADMFQEGRDLIEQNIDVF 1234
BLAST of NPHP8 vs. Ensembl Human
Match: RPGRIP1L (RPGRIP1 like [Source:HGNC Symbol;Acc:HGNC:29168]) HSP 1 Score: 537.339 bits (1383), Expect = 6.329e-168 Identity = 340/913 (37.24%), Postives = 531/913 (58.16%), Query Frame = 3
Query: 177 RKTISQWTKDYLEDKYLRLQDDHETLKKHARLQEXXXXXXXXXXXXXXSDAKKNGDIT--PKT--------DDFEEFRRKCSILESQNGLLKDKVKLLQSQLLAQGKKASVYDNVPSRIKSGAIERSNSIQNSGRKNNIR-VIKPRGELYPLSPRRDESVTGDQSLISLNKVVEDLK--YEVHRLQIEN----EELLKKAYRREDEKL----------SPEHYKSNLKDNLDMIRVTRDIKEKEIQVNVLHGKYEDLKTKQQYLERNNREMSDEIERLTSRLRSTDDFAGNAEGQIRNVTVLRKRINDLEATNNDFKKEIYLLKESNDKLTNDAFNTERERDWREKEMNYRAKIAQLELTLKRDVSEKGGVLNKLESERDRVDNAEKEMSNLRLRNYELQAQIEELSDKLKFFSKEASLNPQEIEEALMIIQHKRNMVHAQSTPELDFIQKIDKNKDQDLTRKLLECEMNHAETIQELEKTRSLLRTQYKISNDYRQESEKISQRLDEIKKDYEERLTEYARLLDIRAARIHKLEAQLKDIAYGTRNTQIETILEPD--LEPLAPEI-LERGENILEIHIGRVCLTQQAVENIKDKDPFLFGTWDFYDFETQATGVLRGTSSEFDIKAEYLVKIDDFFLNYLYKNTFPFELHQATGAEYVTLAACQMSCKDIXXXXXXXXXXXXXXXNGLKYHCRAKLVGLRENSKDI-NFGVLEYWIRLKHPMDQVIRQYREKLKAEGYIMGN-----EMSVVEARRP-------IDS----MNELIIRIIRCKGLKSRQKHLQPSPYIAYKFYDHSHHTSVTIPSSNSPEFHDLRRIPVQMNSDLHQYLKLQNLQIYVLDELDPDESVYLGVATIPLIQLCHNKNISGSFELHDNQHASNGTLEVELTWQHSYMYQDNSFT 2774
R+ +S+ +++ LED++LRL D++ LK+HAR QE KIK++ TKL+++ +D K+ + PK + E+ + K LE QN LK+++ + QL QG + + Y+NV SRI +G R + +N+G + R IK + +P + G+ L + +L+ + R QIE E+LK RR++ ++ +SN++DN++MI++ + + EK ++ + GK+ L+ KQ+ L ++ + + L +L+ + E Q+ ++ +RI +L+ ND +KE LLKE+ DKL + AF+ E W+ KE + +IAQLE LK D+++K +L++L++ERD+ + +E L+L+ E + Q++EL ++K +++E +N E+ EAL++I+ ++ Q +L F+ K+D ++DL R + E + HAET+QELEKTR++L Q+KI+ DY+ E E ++++++ +++DYE ++ +Y LLDIRAARIHKLEAQLKDIAYGT+ + + + PD ++ I LERGEN+ EIHI +V + + ++ DK+P F T+ FYDFE Q T V+RG E++ ++YLV ++D FL Y+ KNT E+HQA EY T+AACQ+ +I EKS + C A L+G + DI NFG +EYW RL+ PMDQ IR YRE+ KA GYI N M + + P DS +NEL I I C L+SR HLQP PY+ YKF+D + H + IPSSN P+F D PV MN DL +YLK ++L YV D+ D E++Y+G +PLI L H++ ISG FEL D+Q GT+ V L W+ +Y+ S T
Sbjct: 39 RQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTG---RRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKE----QKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHLERGENLFEIHINKVTFSSEVLQASGDKEPVTFCTYAFYDFELQTTPVVRGLHPEYNFTSQYLVHVNDLFLQYIQKNTITLEVHQAYSTEYETIAACQLKFHEILEKSG-------------RIFCTASLIGTK---GDIPNFGTVEYWFRLRVPMDQAIRLYRERAKALGYITSNFKGPEHMQSLSQQAPKTAQLSSTDSTDGNLNELHITIRCCNHLQSRASHLQPHPYVVYKFFDFADHDTAIIPSSNDPQFDDHMYFPVPMNMDLDRYLKSESLSFYVFDDSDTQENIYIGKVNVPLISLAHDRCISGIFELTDHQKHPAGTIHVILKWKFAYLPPSGSIT 928 HSP 2 Score: 59.6918 bits (143), Expect = 4.163e-8 Identity = 42/139 (30.22%), Postives = 73/139 (52.52%), Query Frame = 3
Query: 3513 DEIVVEISSVEIADSADLLTDNNIKFIYVEYRLPGISLESTETISLQKPSVNQEIKKMNYNFKKTFDVSFNKNYMIRQHIATMLT--EEPNKYIVFTLVQEPTADSE-ADCEDIGTAKVNVKTLLKESRNLENERIPIY 3920
++I +EI ++ + DS + D+ I+ ++VE R + E T +SL KP Q + YN+ V N R + +L E PN+ + FT+V +P D + +CEDIG A V++ + +E R+L + I ++
Sbjct: 1067 EKIRIEIIALSLNDS-QVTMDDTIQRLFVECRFYSLPAEET-PVSLPKPKSGQWVY---YNYSNVIYVDKENNKAKRDILKAILQKQEMPNRSLRFTVVSDPPEDEQDLECEDIGVAHVDLADMFQEGRDLIEQNIDVF 1200
BLAST of NPHP8 vs. Ensembl Human
Match: RPGRIP1L (RPGRIP1 like [Source:HGNC Symbol;Acc:HGNC:29168]) HSP 1 Score: 538.11 bits (1385), Expect = 9.731e-168 Identity = 340/913 (37.24%), Postives = 531/913 (58.16%), Query Frame = 3
Query: 177 RKTISQWTKDYLEDKYLRLQDDHETLKKHARLQEXXXXXXXXXXXXXXSDAKKNGDIT--PKT--------DDFEEFRRKCSILESQNGLLKDKVKLLQSQLLAQGKKASVYDNVPSRIKSGAIERSNSIQNSGRKNNIR-VIKPRGELYPLSPRRDESVTGDQSLISLNKVVEDLK--YEVHRLQIEN----EELLKKAYRREDEKL----------SPEHYKSNLKDNLDMIRVTRDIKEKEIQVNVLHGKYEDLKTKQQYLERNNREMSDEIERLTSRLRSTDDFAGNAEGQIRNVTVLRKRINDLEATNNDFKKEIYLLKESNDKLTNDAFNTERERDWREKEMNYRAKIAQLELTLKRDVSEKGGVLNKLESERDRVDNAEKEMSNLRLRNYELQAQIEELSDKLKFFSKEASLNPQEIEEALMIIQHKRNMVHAQSTPELDFIQKIDKNKDQDLTRKLLECEMNHAETIQELEKTRSLLRTQYKISNDYRQESEKISQRLDEIKKDYEERLTEYARLLDIRAARIHKLEAQLKDIAYGTRNTQIETILEPD--LEPLAPEI-LERGENILEIHIGRVCLTQQAVENIKDKDPFLFGTWDFYDFETQATGVLRGTSSEFDIKAEYLVKIDDFFLNYLYKNTFPFELHQATGAEYVTLAACQMSCKDIXXXXXXXXXXXXXXXNGLKYHCRAKLVGLRENSKDI-NFGVLEYWIRLKHPMDQVIRQYREKLKAEGYIMGN-----EMSVVEARRP-------IDS----MNELIIRIIRCKGLKSRQKHLQPSPYIAYKFYDHSHHTSVTIPSSNSPEFHDLRRIPVQMNSDLHQYLKLQNLQIYVLDELDPDESVYLGVATIPLIQLCHNKNISGSFELHDNQHASNGTLEVELTWQHSYMYQDNSFT 2774
R+ +S+ +++ LED++LRL D++ LK+HAR QE KIK++ TKL+++ +D K+ + PK + E+ + K LE QN LK+++ + QL QG + + Y+NV SRI +G R + +N+G + R IK + +P + G+ L + +L+ + R QIE E+LK RR++ ++ +SN++DN++MI++ + + EK ++ + GK+ L+ KQ+ L ++ + + L +L+ + E Q+ ++ +RI +L+ ND +KE LLKE+ DKL + AF+ E W+ KE + +IAQLE LK D+++K +L++L++ERD+ + +E L+L+ E + Q++EL ++K +++E +N E+ EAL++I+ ++ Q +L F+ K+D ++DL R + E + HAET+QELEKTR++L Q+KI+ DY+ E E ++++++ +++DYE ++ +Y LLDIRAARIHKLEAQLKDIAYGT+ + + + PD ++ I LERGEN+ EIHI +V + + ++ DK+P F T+ FYDFE Q T V+RG E++ ++YLV ++D FL Y+ KNT E+HQA EY T+AACQ+ +I EKS + C A L+G + DI NFG +EYW RL+ PMDQ IR YRE+ KA GYI N M + + P DS +NEL I I C L+SR HLQP PY+ YKF+D + H + IPSSN P+F D PV MN DL +YLK ++L YV D+ D E++Y+G +PLI L H++ ISG FEL D+Q GT+ V L W+ +Y+ S T
Sbjct: 39 RQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTG---RRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKE----QKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHLERGENLFEIHINKVTFSSEVLQASGDKEPVTFCTYAFYDFELQTTPVVRGLHPEYNFTSQYLVHVNDLFLQYIQKNTITLEVHQAYSTEYETIAACQLKFHEILEKSG-------------RIFCTASLIGTK---GDIPNFGTVEYWFRLRVPMDQAIRLYRERAKALGYITSNFKGPEHMQSLSQQAPKTAQLSSTDSTDGNLNELHITIRCCNHLQSRASHLQPHPYVVYKFFDFADHDTAIIPSSNDPQFDDHMYFPVPMNMDLDRYLKSESLSFYVFDDSDTQENIYIGKVNVPLISLAHDRCISGIFELTDHQKHPAGTIHVILKWKFAYLPPSGSIT 928 HSP 2 Score: 60.077 bits (144), Expect = 3.859e-8 Identity = 42/139 (30.22%), Postives = 73/139 (52.52%), Query Frame = 3
Query: 3513 DEIVVEISSVEIADSADLLTDNNIKFIYVEYRLPGISLESTETISLQKPSVNQEIKKMNYNFKKTFDVSFNKNYMIRQHIATMLT--EEPNKYIVFTLVQEPTADSE-ADCEDIGTAKVNVKTLLKESRNLENERIPIY 3920
++I +EI ++ + DS + D+ I+ ++VE R + E T +SL KP Q + YN+ V N R + +L E PN+ + FT+V +P D + +CEDIG A V++ + +E R+L + I ++
Sbjct: 1113 EKIRIEIIALSLNDS-QVTMDDTIQRLFVECRFYSLPAEET-PVSLPKPKSGQWVY---YNYSNVIYVDKENNKAKRDILKAILQKQEMPNRSLRFTVVSDPPEDEQDLECEDIGVAHVDLADMFQEGRDLIEQNIDVF 1246
BLAST of NPHP8 vs. Ensembl Human
Match: RPGRIP1L (RPGRIP1 like [Source:HGNC Symbol;Acc:HGNC:29168]) HSP 1 Score: 537.724 bits (1384), Expect = 2.464e-167 Identity = 340/913 (37.24%), Postives = 531/913 (58.16%), Query Frame = 3
Query: 177 RKTISQWTKDYLEDKYLRLQDDHETLKKHARLQEXXXXXXXXXXXXXXSDAKKNGDIT--PK--------TDDFEEFRRKCSILESQNGLLKDKVKLLQSQLLAQGKKASVYDNVPSRIKSGAIERSNSIQNSGRKNNIR-VIKPRGELYPLSPRRDESVTGDQSLISLNKVVEDLK--YEVHRLQIEN----EELLKKAYRREDEKL----------SPEHYKSNLKDNLDMIRVTRDIKEKEIQVNVLHGKYEDLKTKQQYLERNNREMSDEIERLTSRLRSTDDFAGNAEGQIRNVTVLRKRINDLEATNNDFKKEIYLLKESNDKLTNDAFNTERERDWREKEMNYRAKIAQLELTLKRDVSEKGGVLNKLESERDRVDNAEKEMSNLRLRNYELQAQIEELSDKLKFFSKEASLNPQEIEEALMIIQHKRNMVHAQSTPELDFIQKIDKNKDQDLTRKLLECEMNHAETIQELEKTRSLLRTQYKISNDYRQESEKISQRLDEIKKDYEERLTEYARLLDIRAARIHKLEAQLKDIAYGTRNTQIETILEPD--LEPLAPEI-LERGENILEIHIGRVCLTQQAVENIKDKDPFLFGTWDFYDFETQATGVLRGTSSEFDIKAEYLVKIDDFFLNYLYKNTFPFELHQATGAEYVTLAACQMSCKDIXXXXXXXXXXXXXXXNGLKYHCRAKLVGLRENSKDI-NFGVLEYWIRLKHPMDQVIRQYREKLKAEGYIMGN-----EMSVVEARRP-------IDS----MNELIIRIIRCKGLKSRQKHLQPSPYIAYKFYDHSHHTSVTIPSSNSPEFHDLRRIPVQMNSDLHQYLKLQNLQIYVLDELDPDESVYLGVATIPLIQLCHNKNISGSFELHDNQHASNGTLEVELTWQHSYMYQDNSFT 2774
R+ +S+ +++ LED++LRL D++ LK+HAR QE KIK++ TKL+++ +D K+ + PK + E+ + K LE QN LK+++ + QL QG + + Y+NV SRI +G R + +N+G + R IK + +P + G+ L + +L+ + R QIE E+LK RR++ ++ +SN++DN++MI++ + + EK ++ + GK+ L+ KQ+ L ++ + + L +L+ + E Q+ ++ +RI +L+ ND +KE LLKE+ DKL + AF+ E W+ KE + +IAQLE LK D+++K +L++L++ERD+ + +E L+L+ E + Q++EL ++K +++E +N E+ EAL++I+ ++ Q +L F+ K+D ++DL R + E + HAET+QELEKTR++L Q+KI+ DY+ E E ++++++ +++DYE ++ +Y LLDIRAARIHKLEAQLKDIAYGT+ + + + PD ++ I LERGEN+ EIHI +V + + ++ DK+P F T+ FYDFE Q T V+RG E++ ++YLV ++D FL Y+ KNT E+HQA EY T+AACQ+ +I EKS + C A L+G + DI NFG +EYW RL+ PMDQ IR YRE+ KA GYI N M + + P DS +NEL I I C L+SR HLQP PY+ YKF+D + H + IPSSN P+F D PV MN DL +YLK ++L YV D+ D E++Y+G +PLI L H++ ISG FEL D+Q GT+ V L W+ +Y+ S T
Sbjct: 39 RQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTG---RRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKE----QKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHLERGENLFEIHINKVTFSSEVLQASGDKEPVTFCTYAFYDFELQTTPVVRGLHPEYNFTSQYLVHVNDLFLQYIQKNTITLEVHQAYSTEYETIAACQLKFHEILEKSG-------------RIFCTASLIGTK---GDIPNFGTVEYWFRLRVPMDQAIRLYRERAKALGYITSNFKGPEHMQSLSQQAPKTAQLSSTDSTDGNLNELHITIRCCNHLQSRASHLQPHPYVVYKFFDFADHDTAIIPSSNDPQFDDHMYFPVPMNMDLDRYLKSESLSFYVFDDSDTQENIYIGKVNVPLISLAHDRCISGIFELTDHQKHPAGTIHVILKWKFAYLPPSGSIT 928 HSP 2 Score: 59.6918 bits (143), Expect = 4.296e-8 Identity = 42/139 (30.22%), Postives = 73/139 (52.52%), Query Frame = 3
Query: 3513 DEIVVEISSVEIADSADLLTDNNIKFIYVEYRLPGISLESTETISLQKPSVNQEIKKMNYNFKKTFDVSFNKNYMIRQHIATMLT--EEPNKYIVFTLVQEPTADSE-ADCEDIGTAKVNVKTLLKESRNLENERIPIY 3920
++I +EI ++ + DS + D+ I+ ++VE R + E T +SL KP Q + YN+ V N R + +L E PN+ + FT+V +P D + +CEDIG A V++ + +E R+L + I ++
Sbjct: 1147 EKIRIEIIALSLNDS-QVTMDDTIQRLFVECRFYSLPAEET-PVSLPKPKSGQWVY---YNYSNVIYVDKENNKAKRDILKAILQKQEMPNRSLRFTVVSDPPEDEQDLECEDIGVAHVDLADMFQEGRDLIEQNIDVF 1280
BLAST of NPHP8 vs. Ensembl Zebrafish
Match: rpgrip1l (RPGRIP1 like [Source:ZFIN;Acc:ZDB-GENE-081104-81]) HSP 1 Score: 483.411 bits (1243), Expect = 6.167e-148 Identity = 324/924 (35.06%), Postives = 523/924 (56.60%), Query Frame = 3
Query: 141 NAVIPKMDLAQ---ERKTISQWTKDYLEDKYLRLQDDHETLKKHARLQEXXXXXXXXXXXXXXSDAKK--NGDITPKTDDFEEFRRKCSILESQNGLLKDKVKLLQSQLLAQGKKASVYDNVPSRIKSGA--IERSNSIQNSGR----KNNIRVIKPRGELYP---LSPRRDESVTGDQ--SLISLNKVVEDLKYEVHRLQIENEELLKKAYRREDEKL----------SPEHYKSNLKDNLDMIRVTRDIKEKEIQVNVLHGKY----EDLKTKQQY-------LERNNREMSDEIERLTSRLRSTDDFAGNAEGQIRNVTVLRKRINDLEATNNDFKKEIYLLKESNDKLTNDAFNTERERDWREKEMNYRAKIAQLELTLKRDVSEKGGVLNKLESERDRVDNAEKEMSNLRLRNYELQAQIEELSDKLKFFSKEASLNPQEIEEALMIIQHKRNMVHAQSTPELDFIQKIDKNKDQDLTRKLLECEMNHAETIQELEKTRSLLRTQYKISNDYRQESEKISQRLDEIKKDYEERLTEYARLLDIRAARIHKLEAQLKDIAYGTRNTQIETILEPD--LEPLAPEI-----LERGENILEIHIGRVCLTQQAVENIKDKDPFLFGTWDFYDFETQATGVLRGTSSEFDIKAEYLVKIDDFFLNYLYKNTFPFELHQATGAEYVTLAACQMSCKDIXXXXXXXXXXXXXXXNGLKYHCRAKLVGLRENSKDIN-FGVLEYWIRLKHPMDQVIRQYREKLKAEGYIMGNEMSVVEARRPIDS--------MNELIIRIIRCKGLKSRQKHLQPSPYIAYKFYDHSHHTSVTIPSSNSPEFHDLRRIPVQMNSDLHQYLKLQNLQIYVLDELDPDESVYLGVATIPLIQLCHNKNISGSFELHDNQHASNGTLEVELTWQHSYM 2753
A +P L+Q ER+ +S+ +++ LEDKYLRLQD++ TLK+H QE KI+++ TKL+++ D K+ G + EE + K LE QN LK ++ + QL Q ++ + Y ++ SRI +G + +++ + R K +R ++ P L PR S+ + + +L V+E + ++ L+ + E+++ +R D + + +KDN++MI++ + + EK + VL G++ E +KT + +E NR++ +E RL+S E QI + + + + +L+ D +KE LLKE+ DKL AF+ +E+ WR +E + ++AQLE LK D+++K +L+K+++ERD +N +E L+LR E + Q+EE+ D++KFF+KE+ ++ E+ EALM+I+ +R +Q + EL F++K++++ D+ R L E + +AET+QELEKTR++L Q+KI+ DY+ E E +++ +D++K +YE + + A+LLD+RAA+I KLEAQLKDIAYGT+ + PD + + E L RGEN+LEIH+G+ + +AVE++KDKDP F T+ FYDFE Q+T V+ G ++ ++YLV++DD FLNYL+ N+ E+ A G + T+AA Q+ + + +G K +LVG+ S +I FG LEYW++LK MDQ IR Y+E++KA G++ + P S +NEL I I C LK + H QPSPYI YK YD H + IP + P+F D P+ MNS+L +L+ + L +YV D+LD + +YLG A +PL L H+K I+G FEL D +G + V L W +Y+
Sbjct: 19 GAALPDSLLSQNIRERQNVSKLSREELEDKYLRLQDENLTLKQHTCKQEDKIRRMATKLIRLVKDRKQRDGGRDVEMEEMMEELQEKVQELEKQNEGLKRRLLAAKQQLQVQSRRHTPYAHIQSRINTGLRRVPDTHTPVTTSRPHTPKAALRHVEGEMSAKPPQSLLPRYGHSLLDEARAEIRNLENVIESQQMQMEELE-RSAEMMRDQLKRRDREFEESLLQVREQQASGQRLTIKDNVEMIKLQKLLSEKANTLAVLEGRFLQQQESMKTLKASHDAALLKVEDGNRQLKEE------RLKSL-----QLETQITSRALEHRHLLELQERIQDLEKERDLLKENCDKLVKSAFDVSQEQKWRTREQQLKLQVAQLETALKSDLADKNQILDKIKAERDVNENLTQENKQLQLRYLEQKQQLEEIKDRMKFFTKESEIDAAELSEALMLIKVRR----SQKSGELGFLEKVEEDVKVDVERSLKELQATYAETVQELEKTRNMLIIQHKINKDYQAEVEAVNRMMDDLKLEYELKSEKLAQLLDMRAAKIRKLEAQLKDIAYGTKT----HVFRPDETSDDVTDEFEGTVQLARGENLLEIHLGKGQFSPEAVESLKDKDPSTFCTYAFYDFELQSTPVVHGERPDYSFSSQYLVRVDDLFLNYLHTNSITVEIQLAEGLNFRTVAAGQIRLNQL------------LERDG-KVFSTIQLVGV---SDEIQVFGSLEYWLKLKVSMDQAIRLYKERVKALGFLKTSLRDSKAFSVPAPSSSSLMNGDLNELSISIHSCCNLKPKGPHTQPSPYIVYKLYDFPDHDTPIIPCTTEPQFEDHMVFPMTMNSNLDAFLRSEALVVYVFDDLDVENQLYLGKARVPLDSLAHDKTITGLFELTDPAGLPSGQINVTLKWSFTYL 906
BLAST of NPHP8 vs. Ensembl Zebrafish
Match: rpgrip1l (RPGRIP1 like [Source:ZFIN;Acc:ZDB-GENE-081104-81]) HSP 1 Score: 483.411 bits (1243), Expect = 6.167e-148 Identity = 324/924 (35.06%), Postives = 523/924 (56.60%), Query Frame = 3
Query: 141 NAVIPKMDLAQ---ERKTISQWTKDYLEDKYLRLQDDHETLKKHARLQEXXXXXXXXXXXXXXSDAKK--NGDITPKTDDFEEFRRKCSILESQNGLLKDKVKLLQSQLLAQGKKASVYDNVPSRIKSGA--IERSNSIQNSGR----KNNIRVIKPRGELYP---LSPRRDESVTGDQ--SLISLNKVVEDLKYEVHRLQIENEELLKKAYRREDEKL----------SPEHYKSNLKDNLDMIRVTRDIKEKEIQVNVLHGKY----EDLKTKQQY-------LERNNREMSDEIERLTSRLRSTDDFAGNAEGQIRNVTVLRKRINDLEATNNDFKKEIYLLKESNDKLTNDAFNTERERDWREKEMNYRAKIAQLELTLKRDVSEKGGVLNKLESERDRVDNAEKEMSNLRLRNYELQAQIEELSDKLKFFSKEASLNPQEIEEALMIIQHKRNMVHAQSTPELDFIQKIDKNKDQDLTRKLLECEMNHAETIQELEKTRSLLRTQYKISNDYRQESEKISQRLDEIKKDYEERLTEYARLLDIRAARIHKLEAQLKDIAYGTRNTQIETILEPD--LEPLAPEI-----LERGENILEIHIGRVCLTQQAVENIKDKDPFLFGTWDFYDFETQATGVLRGTSSEFDIKAEYLVKIDDFFLNYLYKNTFPFELHQATGAEYVTLAACQMSCKDIXXXXXXXXXXXXXXXNGLKYHCRAKLVGLRENSKDIN-FGVLEYWIRLKHPMDQVIRQYREKLKAEGYIMGNEMSVVEARRPIDS--------MNELIIRIIRCKGLKSRQKHLQPSPYIAYKFYDHSHHTSVTIPSSNSPEFHDLRRIPVQMNSDLHQYLKLQNLQIYVLDELDPDESVYLGVATIPLIQLCHNKNISGSFELHDNQHASNGTLEVELTWQHSYM 2753
A +P L+Q ER+ +S+ +++ LEDKYLRLQD++ TLK+H QE KI+++ TKL+++ D K+ G + EE + K LE QN LK ++ + QL Q ++ + Y ++ SRI +G + +++ + R K +R ++ P L PR S+ + + +L V+E + ++ L+ + E+++ +R D + + +KDN++MI++ + + EK + VL G++ E +KT + +E NR++ +E RL+S E QI + + + + +L+ D +KE LLKE+ DKL AF+ +E+ WR +E + ++AQLE LK D+++K +L+K+++ERD +N +E L+LR E + Q+EE+ D++KFF+KE+ ++ E+ EALM+I+ +R +Q + EL F++K++++ D+ R L E + +AET+QELEKTR++L Q+KI+ DY+ E E +++ +D++K +YE + + A+LLD+RAA+I KLEAQLKDIAYGT+ + PD + + E L RGEN+LEIH+G+ + +AVE++KDKDP F T+ FYDFE Q+T V+ G ++ ++YLV++DD FLNYL+ N+ E+ A G + T+AA Q+ + + +G K +LVG+ S +I FG LEYW++LK MDQ IR Y+E++KA G++ + P S +NEL I I C LK + H QPSPYI YK YD H + IP + P+F D P+ MNS+L +L+ + L +YV D+LD + +YLG A +PL L H+K I+G FEL D +G + V L W +Y+
Sbjct: 19 GAALPDSLLSQNIRERQNVSKLSREELEDKYLRLQDENLTLKQHTCKQEDKIRRMATKLIRLVKDRKQRDGGRDVEMEEMMEELQEKVQELEKQNEGLKRRLLAAKQQLQVQSRRHTPYAHIQSRINTGLRRVPDTHTPVTTSRPHTPKAALRHVEGEMSAKPPQSLLPRYGHSLLDEARAEIRNLENVIESQQMQMEELE-RSAEMMRDQLKRRDREFEESLLQVREQQASGQRLTIKDNVEMIKLQKLLSEKANTLAVLEGRFLQQQESMKTLKASHDAALLKVEDGNRQLKEE------RLKSL-----QLETQITSRALEHRHLLELQERIQDLEKERDLLKENCDKLVKSAFDVSQEQKWRTREQQLKLQVAQLETALKSDLADKNQILDKIKAERDVNENLTQENKQLQLRYLEQKQQLEEIKDRMKFFTKESEIDAAELSEALMLIKVRR----SQKSGELGFLEKVEEDVKVDVERSLKELQATYAETVQELEKTRNMLIIQHKINKDYQAEVEAVNRMMDDLKLEYELKSEKLAQLLDMRAAKIRKLEAQLKDIAYGTKT----HVFRPDETSDDVTDEFEGTVQLARGENLLEIHLGKGQFSPEAVESLKDKDPSTFCTYAFYDFELQSTPVVHGERPDYSFSSQYLVRVDDLFLNYLHTNSITVEIQLAEGLNFRTVAAGQIRLNQL------------LERDG-KVFSTIQLVGV---SDEIQVFGSLEYWLKLKVSMDQAIRLYKERVKALGFLKTSLRDSKAFSVPAPSSSSLMNGDLNELSISIHSCCNLKPKGPHTQPSPYIVYKLYDFPDHDTPIIPCTTEPQFEDHMVFPMTMNSNLDAFLRSEALVVYVFDDLDVENQLYLGKARVPLDSLAHDKTITGLFELTDPAGLPSGQINVTLKWSFTYL 906
BLAST of NPHP8 vs. Ensembl Zebrafish
Match: rpgrip1 (RPGR interacting protein 1 [Source:ZFIN;Acc:ZDB-GENE-091204-394]) HSP 1 Score: 209.149 bits (531), Expect = 3.909e-54 Identity = 232/933 (24.87%), Postives = 420/933 (45.02%), Query Frame = 3
Query: 153 PKMDLAQERKTISQWTKDYLEDKYLRLQDDHETLKKHARLQEXXXXXXXXXXXXXXSDAKKNGDITPKTDDFEEFRRKCSILESQNGLLKDKVKLLQSQLLAQGKKASVYDNVPSRIKSGAIERSNSIQNSGRKNNIRVIKPRGELYPLSPRRDESVTGDQSLISLNKVVEDLKYEVHRLQIENEELLKKAYRREDE---------KLSPEHYKSNLKDNLDMIRVTRDIKEKEIQVNVLHGKYEDLKTK--------QQYLERNNREMSDEIERLTSRLRSTDDFAGNAEGQIRNVTV-------LRKRINDLEATNNDFKKEIYLLKESNDKLTN---DAFNTERERDWREKEMNYRAKIAQLELTLKRDVSEKGGVLNKLESERDRVDNAEKE-------MSNLRLRNYELQAQIEE-------LSDKLKFFSKEASLNPQEIEEALMIIQHKRNMVHAQSTPELDFIQKIDKNKDQDLTRKLLECEMNHAETIQELEKTRSLLRTQYKISNDYRQESEKISQRLDEIKKDYEERLTEYARLLDIRAARIHKLEAQLKDIAYGTRNTQIETILE------------PDLEPLAPEILERGENILEIHIGRVCLTQ-----QAVENIKDKDPFLFGTWDFYDFETQATGVLRGTSSEFDIKAEYLVKIDDFFLNYLYKNTFPFELHQATGA-EYVTLAACQMSCKDIXXXXXXXXXXXXXXXNGLKYHCRAKLVGLRENSKDINFGVLEYWIRLKHPMDQVIRQYREKLKAEG---YIMGNEMSVVEARRPIDSM----NELIIRIIRCKGLKSRQKHLQPSPYIAYKFYDHSHHTSVTIPSSNSPEFHDLRRIPVQMNSDLHQYLKLQNLQIYVLDELDPDES-VYLGVATIPLIQLCHNKNISGSFELHDNQHASNGTLEVELTWQHSY 2750
P++ ++R+ + + ++ LED+ RLQ+++ LK+H+R QE K+++L TKLL++ + +G D EE + + LESQ G L+ K+ L + +L G + + + R + R + RGE+ L +L+S + V+E + V L++ + L + +E E K + ++ +KDN+D+IR+ + + EK + V+ K+ L+ Q+ L+ + + ++E L+ +L+ EGQ+ T L++R+ DLE N KK L ES + N D + ER +E +R ++ +L+ L+ SE+ + + E R +D +KE + LR ++ L+ ++ + L +KL +KE ++ +++ E L+ I+ R Q + F+ K D K +D +R L + ++AET+ EL+KTR LL Q++++ D + E + ++ + +++ R E +LL R +I L+AQLK++AY RN + L+ P +E L GE++LE+H+ T A + + + F T+ F DFE +T ++ G + ++Y + D + ELHQA G +++T ++S + + G + R L+G+ G+LE+W+ L HP + E++ + + G+E + E D NEL + + RC GL +R L P Y+ Y+ YD H++ I P F D P+ + +D+ +YL + +L +YV D+ D S YL IPL L + I G + L D + G + V L W++ +
Sbjct: 41 PQVLKIKDRQRLFRVPREQLEDQCHRLQEENTLLKQHSRTQEQKLRRLSTKLLRLKHGSSASGRDGELEDTIEELEARVATLESQKGALQSKLNLAKQHILDLGVRTHIRPRTGRGVDGDGGVRRAAQTAPARCGISSLDDTRGEMDRLL-----------ALLSRSTVIESQQGRVAELELTAQSLRETLRDKEREIEGIVKDLRKQQVDGHRLIIKDNVDVIRLQKQLSEKSAALLVIQEKFGGLQEAYENQLEEGQKSLKESQEALLGKVEELSEQLKQEKQRVLTLEGQLSAATFSLQALGELQERVLDLEGERNLLKKSYDSLLESTMSIQNHQGDKHEEKEERKEELREEGWREELQRLKERLEEARSERKTLEQEKEQMRHEIDQVKKEKERDKDMVMFLREKHDCLEREVLQHRQEVTLLQEKLDSVTKEFDMSVEDLSETLLQIKAFRMQQETQGV--MRFL-KTDV-KFEDTSRDLTAVQASYAETVLELQKTRDLLLLQHRLNADLQNEMTTVLEKSESEREENRRRAEEKDKLLKSRGLQISNLQAQLKELAYSPRNNKRAIPLQYTWTGLEQDSVRPTVESAIITHLHGGESLLEVHLTGATFTPLGLRLMAQDTGEHQGVATFCTYGFLDFEVLSTSLMSGGQPNYGFTSQYALSAFDLEKLMVQGGFIAVELHQALGGVKFLTRGRARISLME------------ALQRRGERVKNRTNLIGVDGEV----IGILEFWVCL-HPQVERTEPQMERVTSRTPVRHTRGSEWAHGEPEEMYDFGVGIPNELEVVLERCVGLSTRWPGLLPDAYLTYRLYDLPPHSTPIIQCCVDPVFEDSASYPLAVTTDVLEYLNVGSLWVYVFDDGDSQTSHTYLAKTPIPLRSLAAGRPIRGDYVLRDPAGSPRGMVRVSLRWKYPF 941 HSP 2 Score: 83.9593 bits (206), Expect = 1.052e-15 Identity = 52/148 (35.14%), Postives = 88/148 (59.46%), Query Frame = 3
Query: 3489 PIKPELNPDEIVVEISSVEIADSADLLTDNNIKFIYVEYRLPGISLESTET-ISLQKPSVNQEIKKMNYNFKKTFDVSFNKNYMIRQHIATML-TEEPNK-YIVFTLVQEPTADSEADCEDIGTAKVNVKTLLKESRNLENERIPIYS 3923
P KP+ D + VEI S+ S+ + D ++ +YVEYRL G+ +E+TET +SL+KP+ +EI +YNF + V +R ++ TML +PN+ + FT+V EP + E +CED+G A ++++ LL ++ ++I + S
Sbjct: 1128 PPKPQKKGDRLRVEILSLSFNPSSSIALDQSVHQVYVEYRLLGVPMETTETPMSLRKPTDGEEI---HYNFTRVIHVDSVGAAPLRHYLYTMLEGTDPNQGRLKFTVVSEPMKEQE-ECEDVGYAYLDLRELLLTGNDVIEKQINVVS 1271
BLAST of NPHP8 vs. Ensembl Zebrafish
Match: rpgrip1 (RPGR interacting protein 1 [Source:ZFIN;Acc:ZDB-GENE-091204-394]) HSP 1 Score: 171.014 bits (432), Expect = 1.646e-42 Identity = 172/682 (25.22%), Postives = 310/682 (45.45%), Query Frame = 3
Query: 834 VNVLHGKYEDLKTKQQYLERNNREMSDEIERLTSRLRSTDDFAGNAEGQIRNVTVLRKRINDLEATNNDFKKEIYLLKESNDKLTN---DAFNTERERDWREKEMNYRAKIAQLELTLKRDVSEKGGVLNKLESERDRVDNAEKE-------MSNLRLRNYELQAQIEE-------LSDKLKFFSKEASLNPQEIEEALMIIQHKRNMVHAQSTPELDFIQKIDKNKDQDLTRKLLECEMNHAETIQELEKTRSLLRTQYKISNDYRQESEKISQRLDEIKKDYEERLTEYARLLDIRAARIHKLEAQLKDIAYGTRNTQIETILE------------PDLEPLAPEILERGENILEIHIGRVCLTQ-----QAVENIKDKDPFLFGTWDFYDFETQATGVLRGTSSEFDIKAEYLVKIDDFFLNYLYKNTFPFELHQATGA-EYVTLAACQMSCKDIXXXXXXXXXXXXXXXNGLKYHCRAKLVGLRENSKDINFGVLEYWIRLKHPMDQVIRQYREKLKAEG---YIMGNEMSVVEARRPIDSM----NELIIRIIRCKGLKSRQKHLQPSPYIAYKFYDHSHHTSVTIPSSNSPEFHDLRRIPVQMNSDLHQYLKLQNLQIYVLDELDPDES-VYLGVATIPLIQLCHNKNISGSFELHDNQHASNGTLEVELTWQHSY 2750
+N+ G+ + LK Q+ L E+S+++++ R+ + + A ++ + L++R+ DLE N KK L ES + N D + ER +E +R ++ +L+ L+ SE+ + + E R +D +KE + LR ++ L+ ++ + L +KL +KE ++ +++ E L+ I+ R Q + F+ K D K +D +R L + ++AET+ EL+KTR LL Q++++ D + E + ++ + +++ R E +LL R +I L+AQLK++AY RN + L+ P +E L GE++LE+H+ T A + + + F T+ F DFE +T ++ G + ++Y + D + ELHQA G +++T ++S + + G + R L+G+ G+LE+W+ L HP + E++ + + G+E + E D NEL + + RC GL +R L P Y+ Y+ YD H++ I P F D P+ + +D+ +YL + +L +YV D+ D S YL IPL L + I G + L D + G + V L W++ +
Sbjct: 19 LNIPKGQ-KSLKESQEALLGKVEELSEQLKQEKQRVLTLEGQLSAATFSLQALGELQERVLDLEGERNLLKKSYDSLLESTMSIQNHQGDKHEEKEERKEELREEGWREELQRLKERLEEARSERKTLEQEKEQMRHEIDQVKKEKERDKDMVMFLREKHDCLEREVLQHRQEVTLLQEKLDSVTKEFDMSVEDLSETLLQIKAFRMQQETQGV--MRFL-KTDV-KFEDTSRDLTAVQASYAETVLELQKTRDLLLLQHRLNADLQNEMTTVLEKSESEREENRRRAEEKDKLLKSRGLQISNLQAQLKELAYSPRNNKRAIPLQYTWTGLEQDSVRPTVESAIITHLHGGESLLEVHLTGATFTPLGLRLMAQDTGEHQGVATFCTYGFLDFEVLSTSLMSGGQPNYGFTSQYALSAFDLEKLMVQGGFIAVELHQALGGVKFLTRGRARISLME------------ALQRRGERVKNRTNLIGVDGEV----IGILEFWVCL-HPQVERTEPQMERVTSRTPVRHTRGSEWAHGEPEEMYDFGVGIPNELEVVLERCVGLSTRWPGLLPDAYLTYRLYDLPPHSTPIIQCCVDPVFEDSASYPLAVTTDVLEYLNVGSLWVYVFDDGDSQTSHTYLAKTPIPLRSLAAGRPIRGDYVLRDPAGSPRGMVRVSLRWKYPF 678 HSP 2 Score: 83.1889 bits (204), Expect = 1.782e-15 Identity = 52/148 (35.14%), Postives = 88/148 (59.46%), Query Frame = 3
Query: 3489 PIKPELNPDEIVVEISSVEIADSADLLTDNNIKFIYVEYRLPGISLESTET-ISLQKPSVNQEIKKMNYNFKKTFDVSFNKNYMIRQHIATML-TEEPNK-YIVFTLVQEPTADSEADCEDIGTAKVNVKTLLKESRNLENERIPIYS 3923
P KP+ D + VEI S+ S+ + D ++ +YVEYRL G+ +E+TET +SL+KP+ +EI +YNF + V +R ++ TML +PN+ + FT+V EP + E +CED+G A ++++ LL ++ ++I + S
Sbjct: 867 PPKPQKKGDRLRVEILSLSFNPSSSIALDQSVHQVYVEYRLLGVPMETTETPMSLRKPTDGEEI---HYNFTRVIHVDSVGAAPLRHYLYTMLEGTDPNQGRLKFTVVSEPMKEQE-ECEDVGYAYLDLRELLLTGNDVIEKQINVVS 1010
BLAST of NPHP8 vs. Ensembl Zebrafish
Match: rpgrip1 (RPGR interacting protein 1 [Source:ZFIN;Acc:ZDB-GENE-091204-394]) HSP 1 Score: 166.007 bits (419), Expect = 6.549e-41 Identity = 163/631 (25.83%), Postives = 285/631 (45.17%), Query Frame = 3
Query: 987 NVTVLRKRINDLEATNNDFKKEIYLLKESNDKLTN---DAFNTERERDWREKEMNYRAKIAQLELTLKRDVSEKGGVLNKLESERDRVDNAEKE-------MSNLRLRNYELQAQIEE-------LSDKLKFFSKEASLNPQEIEEALMIIQHKRNMVHAQSTPELDFIQKIDKNKDQDLTRKLLECEMNHAETIQELEKTRSLLRTQYKISNDYRQESEKISQRLDEIKKDYEERLTEYARLLDIRAARIHKLEAQLKDIAYGTRNTQIETILE------------PDLEPLAPEILERGENILEIHIGRVCLTQ-----QAVENIKDKDPFLFGTWDFYDFETQATGVLRGTSSEFDIKAEYLVKIDDFFLNYLYKNTFPFELHQATGA-EYVTLAACQMSCKDIXXXXXXXXXXXXXXXNGLKYHCRAKLVGLRENSKDINFGVLEYWIRLKHPMDQVIRQYREKLKAEG---YIMGNEMSVVEARRPIDSM----NELIIRIIRCKGLKSRQKHLQPSPYIAYKFYDHSHHTSVTIPSSNSPEFHDLRRIPVQMNSDLHQYLKLQNLQIYVLDELDPDES-VYLGVATIPLIQLCHNKNISGSFELHDNQHASNGTLEVELTWQHSY 2750
+V L++R+ DLE N KK L ES + N D + ER +E +R ++ +L+ L+ SE+ + + E R +D +KE + LR ++ L+ ++ + L +KL +KE ++ +++ E L+ I+ R Q + F+ K D K +D +R L + ++AET+ EL+KTR LL Q++++ D + E + ++ + +++ R E +LL R +I L+AQLK++AY RN + L+ P +E L GE++LE+H+ T A + + + F T+ F DFE +T ++ G + ++Y + D + ELHQA G +++T ++S + + G + R L+G+ G+LE+W+ L HP + E++ + + G+E + E D NEL + + RC GL +R L P Y+ Y+ YD H++ I P F D P+ + +D+ +YL + +L +YV D+ D S YL IPL L + I G + L D + G + V L W++ +
Sbjct: 96 SVLQLQERVLDLEGERNLLKKSYDSLLESTMSIQNHQGDKHEEKEERKEELREEGWREELQRLKERLEEARSERKTLEQEKEQMRHEIDQVKKEKERDKDMVMFLREKHDCLEREVLQHRQEVTLLQEKLDSVTKEFDMSVEDLSETLLQIKAFRMQQETQGV--MRFL-KTDV-KFEDTSRDLTAVQASYAETVLELQKTRDLLLLQHRLNADLQNEMTTVLEKSESEREENRRRAEEKDKLLKSRGLQISNLQAQLKELAYSPRNNKRAIPLQYTWTGLEQDSVRPTVESAIITHLHGGESLLEVHLTGATFTPLGLRLMAQDTGEHQGVATFCTYGFLDFEVLSTSLMSGGQPNYGFTSQYALSAFDLEKLMVQGGFIAVELHQALGGVKFLTRGRARISLME------------ALQRRGERVKNRTNLIGVDGEV----IGILEFWVCL-HPQVERTEPQMERVTSRTPVRHTRGSEWAHGEPEEMYDFGVGIPNELEVVLERCVGLSTRWPGLLPDAYLTYRLYDLPPHSTPIIQCCVDPVFEDSASYPLAVTTDVLEYLNVGSLWVYVFDDGDSQTSHTYLAKTPIPLRSLAAGRPIRGDYVLRDPAGSPRGMVRVSLRWKYPF 705 HSP 2 Score: 82.8037 bits (203), Expect = 2.210e-15 Identity = 52/148 (35.14%), Postives = 88/148 (59.46%), Query Frame = 3
Query: 3489 PIKPELNPDEIVVEISSVEIADSADLLTDNNIKFIYVEYRLPGISLESTET-ISLQKPSVNQEIKKMNYNFKKTFDVSFNKNYMIRQHIATML-TEEPNK-YIVFTLVQEPTADSEADCEDIGTAKVNVKTLLKESRNLENERIPIYS 3923
P KP+ D + VEI S+ S+ + D ++ +YVEYRL G+ +E+TET +SL+KP+ +EI +YNF + V +R ++ TML +PN+ + FT+V EP + E +CED+G A ++++ LL ++ ++I + S
Sbjct: 894 PPKPQKKGDRLRVEILSLSFNPSSSIALDQSVHQVYVEYRLLGVPMETTETPMSLRKPTDGEEI---HYNFTRVIHVDSVGAAPLRHYLYTMLEGTDPNQGRLKFTVVSEPMKEQE-ECEDVGYAYLDLRELLLTGNDVIEKQINVVS 1037
BLAST of NPHP8 vs. Ensembl Xenopus
Match: RPGRIP1L (RPGRIP1-like [Source:NCBI gene;Acc:100271765]) HSP 1 Score: 441.039 bits (1133), Expect = 6.140e-134 Identity = 305/900 (33.89%), Postives = 505/900 (56.11%), Query Frame = 3
Query: 168 AQERKTISQWTKDYLEDKYLRLQDDHETLKKHARLQEXXXXXXXXXXXXXXSDAKK--NGDITPKTDD--------FEEFRRKCSILESQNGLLKDKVKLLQSQLLAQGKKASVYDNVPSRIKSGAIERSNSI--QNSGRKNNIRVIKPRGELYPLSPRRDESVTGDQ--SLISLNKVVEDLKYEV----HRLQIENEELLKKAYRREDEKLS-----PEHYKSNLKDNLDMIRVTRDIKEKEIQVNVLHGKYEDLKTKQQYLERNNREMSDEIERLTSRLRSTDDFAGNAEGQIRNVTVLRKRINDLEATNNDFKKEIYLLKESNDKLTNDAFNTERERDWREKEMNYRAKIAQLELTLKRDVSEKGGVLNKLESERDRVDNAEKEMSNLRLRNYELQAQIEELSDKLKFFSKEASLNPQEIEEALMIIQHKRNMVHAQSTPELDFIQKIDKNKDQDLTRKLLECEMNHAETIQELEKTRSLLRTQYKISNDYRQESEKISQRLDEIKKDYEERLTEYARLLDIRAARIHKLEAQLKDIAYGTRNTQIETILEPD--LEPLAPEI-LERGENILEIHIGRVCLTQQAVENIKDKDPFLFGTWDFYDFETQATGVLRGTSSEFDIKAEYLVKIDDFFLNYLYKNTFPFELHQATGAEYVTLAACQMSCKDIXXXXXXXXXXXXXXXNGLKYHCRAKLVGLRENSKDINFGVLEYWIRLKHPMDQVIRQYREKLKAEGYIM-------GNEMSVVEARRPI-----DSMNELIIRIIRCKGLKSRQKHLQPSPYIAYKFYDHSHHTSVTIPSSNSPEFHDLRRIPVQMNSDLHQYLKLQNLQIYVLDELDPDESVYLGVATIPLIQLCHNKNISGSFELHDNQHASNGTLEVELTWQHSYM 2753
+ER+ +S+ +++ LED+YLR+ D++ LK+HAR QE KIK++ TKL+++ D KK G T + E+ + + LE Q L+ ++ + QL QG + S Y+ V SR+ SG + + + S RK + + PR S+ D + +L VVE + + H I EL K E+ L ++ +K+N+ MI++ + + +K + G+++ L QQ ++ + +++ L ++L+ + N E ++++ T+ ++R +L +D +KE LLKE+ DK+ + + E++R RE+++ +IAQLE LK D+S+K +L+K+ E+++ + ++E LRL+ E + Q+EE + +FF+KE ++ E+ EAL++I+ K + + E DF + +K+ T++LL NHAET+QELEKTR++L TQ+KI+ DY+ E E I+++++ I+ DYE +L +YA LD+RAARI KLEAQLKDIAYGT+ ++ T + D ++ + LE GEN+LEIHI ++ + A+E D++P F T+ FYDFE Q T V+RG +D ++Y +++DD FL Y+ K+T E+H A G +Y T+A CQ+ +I EKS + + LVG++ +++ ++G ++YW RL PM+Q IR Y+E+ KA G+I GN S++ + D++N+L I I C LKSR +PS Y+ Y F+ + H + I +S+SP+F D PV M+S L QYLK + L +V D+ D Y+G A +PL+ L ++ ISG+FEL D S GT++V L W +Y+
Sbjct: 10 VKERQALSRISREELEDRYLRIHDENLLLKQHARKQEEKIKRMATKLIRLVQDRKKAEQGSGTSRRSGRDVELEEIIEQLQERVRELEKQKESLQHRLIAAKQQLQTQGHRHSPYNYVQSRVNSGLRKVAEGVLMHESIRKGMFFFLWGSISTQVILPRYGHSLLEDARAEIRNLENVVEAQRSRIEELEHSTDILRHELQSKEKEYEESFLQFREQQATEKRTTIKENVVMIKLQKQLADKTHAFTEMDGRFQQL---QQSMKTSQEAFLSQVDDLNNQLKEERLKSFNLEKRLQSSTLSQRRTEELLDRISDLEKERDLLKENYDKIYS---SQEQQRKLREQQL--MLQIAQLETALKSDLSDKNEMLDKIRQEKEQNEKLDEENRKLRLQVLEQKQQLEEFHSRFRFFTKENDVDMAELSEALLLIKQKNKNLMFLGSIEDDFSKASEKS-----TKELL---ANHAETVQELEKTRNMLITQHKINKDYQTEVEVITKKVESIQHDYEIKLEQYAHALDVRAARIRKLEAQLKDIAYGTKQYKLTTDITQDDEVDEFDETVHLEWGENMLEIHISKIAFSPTAIETFGDQEPATFCTYAFYDFELQTTPVVRGLRPVYDFTSQYRIRVDDLFLQYIQKSTASLEVHIALGTDYKTVALCQLRFHEILEKSG-------------RIFSASMLVGVQGDTE--SYGTVDYWFRLCVPMEQAIRLYQERAKALGFITSNVREPKGNNQSIIITEPHLYTSADDNLNKLYITIKSCSNLKSRSSPQEPSAYVGYTFFSFADHFTSIIQNSDSPQFEDCMCFPVPMSSSLDQYLKSEVLVFFVFDDNDSINK-YIGKAQVPLLSLAQDRCISGTFELTDKNGHSTGTIKVTLKWNATYL 877 HSP 2 Score: 60.077 bits (144), Expect = 3.482e-8 Identity = 40/142 (28.17%), Postives = 73/142 (51.41%), Query Frame = 3
Query: 3489 PIKPELNPDEIVVEISSVEIADSADLLTDNNIKFIYVEYRLPGISLESTETISLQKPSVNQEIKKMNYNFKKTFDVSFNKNYMIRQHIATMLTEEPNKYIVFTLVQEPTADSE-ADCEDIGTAKVNVKTLLKESRNLENERI 3911
+ L ++I +EI S+ + ++D+ ++ I+ ++VEYR I E T +SLQKP+ +I YN+ V N R + + ++ FT+V +P D + DC+DIG A +N+ +L+ +++ N I
Sbjct: 936 AVNESLQFEKIRIEIISLSLNSTSDVAQNDTIQKLFVEYRFCNIVTEET-PVSLQKPASGLQI---YYNYSNVIHVDKENNQANRDLLRS--------FVKFTVVSDPPEDEQDLDCDDIGFASINLSEILQSGKDVINRSI 1065
BLAST of NPHP8 vs. Ensembl Xenopus
Match: RPGRIP1L (RPGRIP1-like [Source:NCBI gene;Acc:100271765]) HSP 1 Score: 445.277 bits (1144), Expect = 9.943e-134 Identity = 302/908 (33.26%), Postives = 514/908 (56.61%), Query Frame = 3
Query: 168 AQERKTISQWTKDYLEDKYLRLQDDHETLKKHARLQEXXXXXXXXXXXXXXSDAKK--NGDITPKTDD--------FEEFRRKCSILESQNGLLKDKVKLLQSQLLAQGKKASVYDNVPSRIKSG------------AIERSNSIQN-SGRKNNIRVIKPRGELYPLSPRRDESVTGDQSLISLNKVVEDLKYEV----HRLQIENEELLKKAYRREDEKLSPEHYKSNLKDNLDMIRVTRDIKEKEIQVNVLHGKYEDLKTKQQYLERNNREMSDEIERLTSRLRSTDDFAGNAEGQIRNVTVLRKRINDLEATNNDFKKEIYLLKESNDKLTNDAFNT----ERERDWREKEMNYRAKIAQLELTLKRDVSEKGGVLNKLESERDRVDNAEKEMSNLRLRNYELQAQIEELSDKLKFFSKEASLNPQEIEEALMIIQHKRNMVHAQSTPELDFIQKIDKNKDQDLTRKLLECEMNHAETIQELEKTRSLLRTQYKISNDYRQESEKISQRLDEIKKDYEERLTEYARLLDIRAARIHKLEAQLKDIAYGTRNTQIETILEPD--LEPLAPEI-LERGENILEIHIGRVCLTQQAVENIKDKDPFLFGTWDFYDFETQATGVLRGTSSEFDIKAEYLVKIDDFFLNYLYKNTFPFELHQATGAEYVTLAACQMSCKDIXXXXXXXXXXXXXXXNGLKYHCRAKLVGLRENSKDINFGVLEYWIRLKHPMDQVIRQYREKLKAEGYIM-------GNEMSVVEARRPI-----DSMNELIIRIIRCKGLKSRQKHLQPSPYIAYKFYDHSHHTSVTIPSSNSPEFHDLRRIPVQMNSDLHQYLKLQNLQIYVLDELDPDESVYLGVATIPLIQLCHNKNISGSFELHDNQHASNGTLEVELTWQHSYM 2753
+ER+ +S+ +++ LED+YLR+ D++ LK+HAR QE KIK++ TKL+++ D KK G T + E+ + + LE Q L+ ++ + QL QG + S Y+ V SR+ SG +I + IQ+ + +VI PR L R E + + + +E+L++ H LQ + +E ++++ + E+ + E ++ +K+N+ MI++ + + +K + G+++ L+ + ++ + +++ L ++L+ + N E ++++ T+ ++R +L +D +KE LLKE+ DK+ + AF+ E++R RE+++ +IAQLE LK D+S+K +L+K+ E+++ + ++E LRL+ E + Q+EE + +FF+KE ++ E+ EAL++I+ + + Q L F+ I+ + + + E NHAET+QELEKTR++L TQ+KI+ DY+ E E I+++++ I+ DYE +L +YA LD+RAARI KLEAQLKDIAYGT+ ++ T + D ++ + LE GEN+LEIHI ++ + A+E D++P F T+ FYDFE Q T V+RG +D ++Y +++DD FL Y+ K+T E+H A G +Y T+A CQ+ +I EKS + + LVG++ +++ ++G ++YW RL PM+Q IR Y+E+ KA G+I GN S++ + D++N+L I I C LKSR +PS Y+ Y F+ + H + I +S+SP+F D PV M+S L QYLK + L +V D+ D Y+G A +PL+ L ++ ISG+FEL D S GT++V L W +Y+
Sbjct: 36 VKERQALSRISREELEDRYLRIHDENLLLKQHARKQEEKIKRMATKLIRLVQDRKKAEQGSGTSRRSGRDVELEEIIEQLQERVRELEKQKESLQHRLIAAKQQLQTQGHRHSPYNYVQSRVNSGLRKVAEGVLMHESIRKGMQIQDPEMTSKSTQVILPRYGHSLLEDARAEIRNLENVVEAQRSRIEELEHSTDILRHELQSKEKEY-EESFLQFREQQATEK-RTTIKENVVMIKLQKQLADKTHAFTEMDGRFQQLQQDLKSMKTSQEAFLSQVDDLNNQLKEERLKSFNLEKRLQSSTLSQRRTEELLDRISDLEKERDLLKENYDKIYSSAFDVNNSQEQQRKLREQQL--MLQIAQLETALKSDLSDKNEMLDKIRQEKEQNEKLDEENRKLRLQVLEQKQQLEEFHSRFRFFTKENDVDMAELSEALLLIKTR----NQQKNKNLMFLGSIEDDFSKASEKSTKELLANHAETVQELEKTRNMLITQHKINKDYQTEVEVITKKVESIQHDYEIKLEQYAHALDVRAARIRKLEAQLKDIAYGTKQYKLTTDITQDDEVDEFDETVHLEWGENMLEIHISKIAFSPTAIETFGDQEPATFCTYAFYDFELQTTPVVRGLRPVYDFTSQYRIRVDDLFLQYIQKSTASLEVHIALGTDYKTVALCQLRFHEILEKSG-------------RIFSASMLVGVQGDTE--SYGTVDYWFRLCVPMEQAIRLYQERAKALGFITSNVREPKGNNQSIIITEPHLYTSADDNLNKLYITIKSCSNLKSRSSPQEPSAYVGYTFFSFADHFTSIIQNSDSPQFEDCMCFPVPMSSSLDQYLKSEVLVFFVFDDNDSINK-YIGKAQVPLLSLAQDRCISGTFELTDKNGHSTGTIKVTLKWNATYL 919 HSP 2 Score: 73.9442 bits (180), Expect = 2.122e-12 Identity = 47/150 (31.33%), Postives = 83/150 (55.33%), Query Frame = 3
Query: 3489 PIKPELNP--DEIVVEISSVEIADSADLLTDNNIKFIYVEYRLPGISLESTETISLQKPSVNQEIKKMNYNFKKTFDVSFNKNYMIRQHIATMLTE--EPNKYIVFTLVQEPTADSE-ADCEDIGTAKVNVKTLLKESRNLENERIPIYS 3923
P++ +L P ++I +EI S+ + ++D+ ++ I+ ++VEYR I E T +SLQKP+ +I YN+ V N R + ++L + N + FT+V +P D + DC+DIG A +N+ +L+ +++ N I IYS
Sbjct: 1094 PVRKDLKPQFEKIRIEIISLSLNSTSDVAQNDTIQKLFVEYRFCNIVTEET-PVSLQKPASGLQIY---YNYSNVIHVDKENNQANRDLLRSLLNDPNTSNGSVKFTVVSDPPEDEQDLDCDDIGFASINLSEILQSGKDVINRSIEIYS 1239
BLAST of NPHP8 vs. Ensembl Xenopus
Match: RPGRIP1L (RPGRIP1-like [Source:NCBI gene;Acc:100271765]) HSP 1 Score: 436.032 bits (1120), Expect = 3.581e-132 Identity = 303/897 (33.78%), Postives = 501/897 (55.85%), Query Frame = 3
Query: 168 AQERKTISQWTKDYLEDKYLRLQDDHETLKKHARLQEXXXXXXXXXXXXXXSDAKK--NGDITPKTDD--------FEEFRRKCSILESQNGLLKDKVKLLQSQLLAQGKKASVYDNVPSRIKSGAIERSNSI--QNSGRKNNIRVIKPRGELYPLSPRRDESVTGDQ--SLISLNKVVEDLKYEV----HRLQIENEELLKKAYRREDEKLS-----PEHYKSNLKDNLDMIRVTRDIKEKEIQVNVLHGKYEDLKTKQQYLERNNREMSDEIERLTSRLRSTDDFAGNAEGQIRNVTVLRKRINDLEATNNDFKKEIYLLKESNDKLTNDAFNTERERDWREKEMNYRAKIAQLELTLKRDVSEKGGVLNKLESERDRVDNAEKEMSNLRLRNYELQAQIEELSDKLKFFSKEASLNPQEIEEALMIIQHKRNMVHAQSTPELDFIQKIDKNKDQDLTRKLLECEMNHAETIQELEKTRSLLRTQYKISNDYRQESEKISQRLDEIKKDYEERLTEYARLLDIRAARIHKLEAQLKDIAYGTRNTQIETILEPD--LEPLAPEI-LERGENILEIHIGRVCLTQQAVENIKDKDPFLFGTWDFYDFETQATGVLRGTSSEFDIKAEYLVKIDDFFLNYLYKNTFPFELHQATGAEYVTLAACQMSCKDIXXXXXXXXXXXXXXXNGLKYHCRAKLVGLRENSKDINFGVLEYWIRLKHPMDQVIRQYREKLKAEGYIM-------GNEMSVVEARRPI--DSMNELIIRIIRCKGLKSRQKHLQPSPYIAYKFYDHSHHTSVTIPSSNSPEFHDLRRIPVQMNSDLHQYLKLQNLQIYVLDELDPDESVYLGVATIPLIQLCHNKNISGSFELHDNQHASNGTLEVELTWQHSYM 2753
+ER+ +S+ +++ LED+YLR+ D++ LK+HAR QE KIK++ TKL+++ D KK G T + E+ + + LE Q L+ ++ + QL QG + S Y+ V SR+ SG + + + S RK + + PR S+ D + +L VVE + + H I EL K E+ L ++ +K+N+ MI++ + + +K + G+++ L+ Q +++ L ++L+ + N E ++++ T+ ++R +L +D +KE LLKE+ DK+ + + E++R RE+++ +IAQLE LK D+S+K +L+K+ E+++ + ++E LRL+ E + Q+EE + +FF+KE ++ E+ EAL++I+ K + + E DF + +K+ T++LL NHAET+QELEKTR++L TQ+KI+ DY+ E E I+++++ I+ DYE +L +YA LD+RAARI KLEAQLKDIAYGT+ ++ T + D ++ + LE GEN+LEIHI ++ + A+E D++P F T+ FYDFE Q T V+RG +D ++Y +++DD FL Y+ K+T E+H A G +Y T+A CQ+ +I EKS + + LVG++ +++ ++G ++YW RL PM+Q IR Y+E+ KA G+I GN + + + D++N+L I I C LKSR +PS Y+ Y F+ + H + I +S+SP+F D PV M+S L QYLK + L +V D+ D Y+G A +PL+ L ++ ISG+FEL D S GT++V L W +Y+
Sbjct: 9 VKERQALSRISREELEDRYLRIHDENLLLKQHARKQEEKIKRMATKLIRLVQDRKKAEQGSGTSRRSGRDVELEEIIEQLQERVRELEKQKESLQHRLIAAKQQLQTQGHRHSPYNYVQSRVNSGLRKVAEGVLMHESIRKGMFFFLWGSISTQVILPRYGHSLLEDARAEIRNLENVVEAQRSRIEELEHSTDILRHELQSKEKEYEESFLQFREQQATEKRTTIKENVVMIKLQKQLADKTHAFTEMDGRFQQLQQTSQ------EAFLSQVDDLNNQLKEERLKSFNLEKRLQSSTLSQRRTEELLDRISDLEKERDLLKENYDKIYS---SQEQQRKLREQQL--MLQIAQLETALKSDLSDKNEMLDKIRQEKEQNEKLDEENRKLRLQVLEQKQQLEEFHSRFRFFTKENDVDMAELSEALLLIKQKNKNLMFLGSIEDDFSKASEKS-----TKELL---ANHAETVQELEKTRNMLITQHKINKDYQTEVEVITKKVESIQHDYEIKLEQYAHALDVRAARIRKLEAQLKDIAYGTKQYKLTTDITQDDEVDEFDETVHLEWGENMLEIHISKIAFSPTAIETFGDQEPATFCTYAFYDFELQTTPVVRGLRPVYDFTSQYRIRVDDLFLQYIQKSTASLEVHIALGTDYKTVALCQLRFHEILEKSG-------------RIFSASMLVGVQGDTE--SYGTVDYWFRLCVPMEQAIRLYQERAKALGFITSNVREPKGNNQAQIFTTIGLSDDNLNKLYITIKSCSNLKSRSSPQEPSAYVGYTFFSFADHFTSIIQNSDSPQFEDCMCFPVPMSSSLDQYLKSEVLVFFVFDDNDSINK-YIGKAQVPLLSLAQDRCISGTFELTDKNGHSTGTIKVTLKWNATYL 870 HSP 2 Score: 62.7734 bits (151), Expect = 4.658e-9 Identity = 41/136 (30.15%), Postives = 74/136 (54.41%), Query Frame = 3
Query: 3513 DEIVVEISSVEIADSADLLTDNNIKFIYVEYRLPGISLESTETISLQKPSVNQEIKKMNYNFKKTFDVSFNKNYMIRQHIATMLTE--EPNKYIVFTLVQEPTADSE-ADCEDIGTAKVNVKTLLKESRNLENERI 3911
++I +EI S+ + ++D+ ++ I+ ++VEYR I E T +SLQKP+ +I YN+ V N R + ++L + N + FT+V +P D + DC+DIG A +N+ +L+ +++ N I
Sbjct: 917 EKIRIEIISLSLNSTSDVAQNDTIQKLFVEYRFCNIVTEET-PVSLQKPASGLQI---YYNYSNVIHVDKENNQANRDLLRSLLNDPNTSNGSVKFTVVSDPPEDEQDLDCDDIGFASINLSEILQSGKDVINRSI 1048
BLAST of NPHP8 vs. Ensembl Xenopus
Match: myrf (myelin regulatory factor [Source:Xenbase;Acc:XB-GENE-1020968]) HSP 1 Score: 65.0846 bits (157), Expect = 8.997e-10 Identity = 102/424 (24.06%), Postives = 218/424 (51.42%), Query Frame = 3
Query: 150 IPKMDLAQERKTISQWTKDYLEDKYLRLQDDHETLKKHARLQEXXXXXXXXXXXXXXSD---------AKKNGDITPKTDDFEEFRRKCSILESQNGLLKDKVKLLQSQLLAQ-GKKASVYDNVPSRIKSGAIERSNSIQNSGRKNNIRV--IKPRGELYPLSPRRDESVTGDQSLISLNKVVEDLKYEVHRLQIENEELLK--KAYRREDEKL--------SPEHYKSNLKDNLDMIRVTRDIKEKEIQVNVLHGKYEDLK-TKQQYLERNNREMS-------DEIERLTSRLRSTDDFAGNAEGQIRNVTVLRKRINDLEATNNDFKKEIYLLKESNDKLTNDAFNTERERDWREKEMNYRAKIAQLELTLKRDVSEKGGVLNK--LESERDRVDNAEKEMSNLRLRNYELQAQIEELSDKL 1325
+ + DL R+ +S +++ LED ++R+ +++ LK HAR E KIK++GTKLL++TSD A+ +G + E+ + + LE +N L+ K+ + +L Q G + Y V +R SG R N + K +RV ++ R E+++ D++ + ++ ++ + +R+ ++ +LK ++ R +D ++ E+ ++++++N+ +IR+ ++++EK + L ++ LK + + L++N + ++ +++ LTS+L++ E + ++V L++ + + + D +KE LLKE+ D L + N + + E R KI+ LE + +S+K LNK L+ ER++ ++ +KE+S L ++ E +++ +K+
Sbjct: 48 VKEKDLKTHRR-VSHISREELEDNFIRIHEENILLKDHARKMEDKIKRMGTKLLRVTSDLAQTGKSFGARHDGRDLEAEETIEDLQDRVRDLEHKNESLRHKLVTYKQRLQVQNGCRHCPYSTVAARTDSGV--RKNIVLPHNIKRGLRVQSLEARPPQVCQVQACGETLS-DEAREEIERLFNLIESQNNRVDDKSTVVLKSMESMRSKDAEMMLYLQKMQQAENQRTSIQENVMLIRLQKELREKNTTLCALKEQFHQLKESYETELQQNQKSLTLSHEAVLTQLQDLTSQLKAERAKVVAMEIEQQSVLNLQRSLQEFQERVTDLEKENALLKENYDSLLKSSLNEDNISSKQAIESELRGKISLLEEQIHHHISDK--TLNKEHLQHEREQNEHLKKEVSQLHMQLLEKIQEVKSYQEKV 465 HSP 2 Score: 65.0846 bits (157), Expect = 1.065e-9 Identity = 42/149 (28.19%), Postives = 84/149 (56.38%), Query Frame = 3
Query: 3489 PIKPELNPDEIV-VEISSVEIADSADLLTDNNIKFIYVEYRLPGISLESTET-ISLQKPSVNQEIKKMNYNFKKTFDVSFNKNYMIRQHIATML-TEEPNKYIV---FTLVQEPTADSEADCEDIGTAKVNVKTLLKESRNLENERIPI 3917
P PE P ++ VEI S+ + ++++ D+ ++ ++VE+R G+ E TET +SL+KP+ +E + Y+F K + +++ R + +L + N IV FT+V +P + E +C D+G A ++++ LL+ + + E + +
Sbjct: 1098 PSVPEKPPSSMIRVEIMSLTLNPYSEVMGDSAVQRLFVEFRFAGVPPEETETPVSLRKPNQGEE---LYYHFSKVIHLDGSEHAERRDFLYMLLEGSDSNGDIVRLKFTVVSDPINEDEEECCDVGYAYMDLRPLLRRAEDKAEETLQV 1243
BLAST of NPHP8 vs. Ensembl Mouse
Match: Rpgrip1l (Rpgrip1-like [Source:MGI Symbol;Acc:MGI:1920563]) HSP 1 Score: 521.161 bits (1341), Expect = 8.301e-162 Identity = 330/910 (36.26%), Postives = 531/910 (58.35%), Query Frame = 3
Query: 177 RKTISQWTKDYLEDKYLRLQDDHETLKKHARLQEXXXXXXXXXXXXXXSDAKKNGDIT--PKT--------DDFEEFRRKCSILESQNGLLKDKVKLLQSQLLAQGKKASVYDNVPSRIKSG---AIERSNSIQNSGRKNNIRVIKPRGELYPLSPRRDESVTGDQ--SLISLNKVVEDLKYEVHRLQIENEELLKKAYRREDE-KLS--------PEHYKSNLKDNLDMIRVTRDIKEKEIQVNVLHGKYEDLKTKQQYLERNNREMSDEIERLTSRLRSTDDFAGNAEGQIRNVTVLRKRINDLEATNNDFKKEIYLLKESNDKLTNDAFNTERERDWREKEMNYRAKIAQLELTLKRDVSEKGGVLNKLESERDRVDNAEKEMSNLRLRNYELQAQIEELSDKLKFFSKEASLNPQEIEEALMIIQHKRNMVHAQSTPELDFIQKIDKNKDQDLTRKLLECEMNHAETIQELEKTRSLLRTQYKISNDYRQESEKISQRLDEIKKDYEERLTEYARLLDIRAARIHKLEAQLKDIAYGTRNTQIETILEPD--LEPLAPEI-LERGENILEIHIGRVCLTQQAVENIKDKDPFLFGTWDFYDFETQATGVLRGTSSEFDIKAEYLVKIDDFFLNYLYKNTFPFELHQATGAEYVTLAACQMSCKDIXXXXXXXXXXXXXXXNGLKYHCRAKLVGLRENSKDI-NFGVLEYWIRLKHPMDQVIRQYREKLKAEGYIMGN-------EMSVVEAR-----RPIDS----MNELIIRIIRCKGLKSRQKHLQPSPYIAYKFYDHSHHTSVTIPSSNSPEFHDLRRIPVQMNSDLHQYLKLQNLQIYVLDELDPDESVYLGVATIPLIQLCHNKNISGSFELHDNQHASNGTLEVELTWQHSYMYQDNSFT 2774
R+ +S+ +++ LED++LRL D++ LK+HAR QE KIK++ TKL+++ +D K+ + PK + E+ + K LE QN +LK+++ + QL QG + + Y V +R+ +G A + S + G+ + + + P + S+ + + +L V++ + ++ L+ E L + R+E+E +LS +SN++DN++ I++ + + EK ++V+ GK+ L+ KQ+ L ++ + + L +L+ + E Q+ +V +R+ +L+ ND +KE LLKE+ DKL N AF+ E W+ KE + +IAQLE LK D+++K VL+KL++ERD+ + +E +L+L+ + + ++ EL +LKFF++E+ +N ++ EAL++I+ ++ Q +L F++K+D ++DL R + E + HAET+QELEKTR++L Q+KI+ DY+ E E ++Q+++ +++DYE ++ +Y LLDIRAARI KLEAQLKDIAYGT+ + + + PD ++ I LERGEN+ EIHI +V + + + DK+ F T+ FYDFE Q T ++RG E++ ++YLV ++D FL Y+ KNT ELHQA +Y T+AACQ+ +I EKS + C LVG + DI NFG +EYW RL+ PMDQ IR YRE+ KA GYI N ++S +A P +S +NEL + + C GL+SR +LQP Y+ YKF+D H + +PSSN P+F D PV MN DL +YLK ++L YV D+ D E++Y+G +PLI L H+K ISG FEL D + + GT++V L W+ +Y+ S T
Sbjct: 39 RQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELERQNEVLKNRLISAKQQLQVQGHRQTSYSRVQARVNTGRRRASASAGSQECPGKGLRFQNVDEAETVQPTLTKYSNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLKRKENEIELSLLQLREQQATDQRSNIRDNVETIKLHKQLVEKSNALSVIEGKFIQLQEKQRTLRISHDALMANGDELNKQLKEQRLKCCSLEKQLHSVRFSERRVEELQDRINDLEKERELLKENYDKLYNSAFSAAHEEQWKLKEQQMKVQIAQLETALKSDLTDKTEVLDKLKTERDQNEKLVQENRDLQLQCLQQKQRLHELQSRLKFFNQESDINADDLSEALLLIKAQKE----QKNGDLSFLEKVDSKINKDLDRSMKELQATHAETVQELEKTRNMLIMQHKINKDYQMEVETVTQKMENLQQDYELKVEQYVHLLDIRAARIQKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHLERGENLFEIHINKVTFSSEVLRASGDKELVTFCTYAFYDFELQTTPIVRGLYPEYNFTSQYLVHVNDLFLQYIQKNTVTLELHQAHSTDYETIAACQLRFHEILEKSG-------------RIFCTTSLVGTK---GDIPNFGTVEYWFRLRVPMDQAIRLYRERAKALGYITSNFKKPEKMQLSSQQAATTAQISPAESTDGNLNELHVTVKCCTGLQSRASYLQPHAYVVYKFFDFPDHDTAIVPSSNDPQFDDHMCFPVPMNMDLDRYLKSESLSFYVFDDSDTQENIYMGKVNVPLISLAHDKCISGIFELMDKEKHAAGTIQVILKWKFTYLPPSGSIT 928 HSP 2 Score: 54.299 bits (129), Expect = 1.578e-6 Identity = 45/164 (27.44%), Postives = 86/164 (52.44%), Query Frame = 3
Query: 3513 DEIVVEISSVEIADSADLLTDNNIKFIYVEYRLPGISLESTETISLQKPSVNQEIKKMNYNFKKTFDVSFNKNYMIRQHIATMLT--EEPNKYIVFTLVQEPTADSE-ADCEDIGTAKVNVKTLLKESRNLENERIPIYSYKNKSVXXXXXXXXXXXLGVLRAI 3995
+EI +EI ++ + DS + ++ I+ +++E R + E T +SL KP Q + YN+ + N +R + +L E P++ + FT+V +P D + +CEDIG A V++ L ++ R++ + I + + IG + VT++ L LR++
Sbjct: 1096 EEIRIEIIALNLNDS-QITREDTIQRLFIECRFYSLPAEET-PMSLPKPQSGQWV---YYNYSNVIYLDKENNPAVRDILKAILQRRELPHRSVRFTVVSDPPEDEQDLECEDIGVAHVDLADLFQKGRDIIEQDIDVLDARTDGGTIGKLKVTVEALHALRSV 1254
BLAST of NPHP8 vs. Ensembl Mouse
Match: Rpgrip1 (retinitis pigmentosa GTPase regulator interacting protein 1 [Source:MGI Symbol;Acc:MGI:1932134]) HSP 1 Score: 301.982 bits (772), Expect = 1.161e-83 Identity = 213/697 (30.56%), Postives = 357/697 (51.22%), Query Frame = 3
Query: 765 KSNLKDNLDMIRVTRDIKEK-------EIQVNVLHGKYEDLKTKQQ-YLERNNREMSDEIERLTSRLRSTDDFAGNAEGQIRNVTVLRKRINDLEATNNDFKKEIYLLKESNDKLTNDAFNTERERDWREKEMNYRAKIA--QLELTLKRDVSEKGGVLNKLESERDRVDNAEKEMSNLRLRNYELQAQIEELSDKLKFFSKEASLNPQEIEEALMIIQHKRNMVHAQST--PELDFIQKID-KNKDQ-DLTRKLLECEMNHAETIQELEKTRSLLRTQYKISNDYRQESEKISQRLDEIKKDYEERLTEYARLLDIRAARIHKLEAQLKDIAYGTRNTQIETILEPDL--EPLAPE---------ILERGENILEIHIGRVCLTQQAVENIKDKDPFLFGTWDFYDFETQATGVLRGTSSEFDIKAEYLVKIDDFFLNYLYKNTFPFELHQATGAEYVTLAACQMSCKDIXXXXXXXXXXXXXXXNGLKYHCRAKLVGLRENSKDINFGVLEYWIRLKHPMDQVIRQYREKLKAEGYIMGNEMSVVEARR---------PIDSMNELIIRIIRCKGLKSRQKHLQPSPYIAYKFYDHSHHTSVTIPSSNSPEFHDLRRIPVQMNSDLHQYLKLQNLQIYVLDELDPDESVYLGVATIPLIQLCHNKNISGSFELHDNQHASNGTLEVELTWQHSYM 2753
++++K+N+++IR+ + ++E+ E Q+ + YEDL K Q L+ + ++ L + L A + Q+ +V++L+ + + + D +KE LL +S D+L + ++ + + ++ ++ QL + + + G L + + R + A ++ L+ ++ ++ Q E+ + L+ + AS +P+E+ E + AQ T P+ D + + K +D+ DL++ L E +++HAET ELEKTR +L Q KI+ Y++E E + D +D+EE+L LLD + +RI +LE QLKD+AYGT L P L EPLA +L EN+ E+H+ + LT A+ D P F T+ FYDFET T + G +D ++Y+V+ D L+YL + +LHQA +EY LA +S + + H A L G + + GVLEYW+RL P+ ++ ++ KA+ Y+ +SV+ AR+ NEL + I RC GL+SR+ QPSPY+ Y+F+ H ++ IP+S++P F D PV + SDL QYL+ + L +YV D+ DP+ YLG A +PL+ L NK+I G F L D+ SNG+++V+L W+ Y+
Sbjct: 228 RASIKENVELIRLKKLLQERNTSLAATEAQLTRVQEAYEDLLQKNQGILDTAHNAFLSQVNELKAELSEESKKAVSLRTQLGDVSILQITLKEFQVRVEDLEKERKLLSDSYDRLLENMLDSSHQPLDSSHQPHWSTELTGKQLPPQVCPLLDQMGTALEETKVFRQATNKAAQD-GKLKFQDTDILYQHEQEEESLQSTATVAS-SPEELCE-----------LAAQPTLLPQTDQRESSEPKAQDENDLSQVLSELQVSHAETTLELEKTRDMLLLQRKINMCYQEELEATLTKADRENRDHEEKLERLNHLLDFKNSRIKQLEEQLKDVAYGT--------LPPSLCLEPLAAHRGDDEVDMSLLHPSENLFELHVHQAFLTPAALTQAGDTQPTTFCTYSFYDFETHCTPLSTGPQPLYDFTSQYVVQADYLLLHYLQGTSVRLDLHQAMASEYHVLATGWISLDKVLGTVE-------------RVHGLATLAG----AGGEDLGVLEYWMRLCLPLKPSLQACNKRKKAQAYL---SVSVLGARKVQSNESRSETWAPQNELRVEITRCCGLRSRRLGRQPSPYVMYRFFTFPDHDTIIIPASSNPYFKDQALFPVLVTSDLDQYLRREALSVYVFDDEDPEPGSYLGRAQVPLLPLAQNKSIKGDFNLTDSGEKSNGSIKVQLDWKSHYL 883 HSP 2 Score: 77.411 bits (189), Expect = 1.245e-13 Identity = 49/173 (28.32%), Postives = 98/173 (56.65%), Query Frame = 3
Query: 3498 PELNPDEIVVEISSVEIADSADLLTDNNIKFIYVEYRLPGISLESTET-ISLQKPSVNQEIKKMNYNFKKTFDVSFNKNYMIRQHIATMLTEEPN--KYIVFTLVQEPTADSEADCEDIGTAKVNVKTLLKESRNLENERIPIYSYKNKSVXXXXXXXXXXXLGVLRAIEKEL 4007
P+ + +++ +EI S+ AD+++D I+ +YVEY+ + L TET +SL+KP +EI +++F K D+ ++ RQ + ML + + FT+V +P + + +C+DIG A + + + + +++ + + I S +N+++ IG + V++Q L I KE+
Sbjct: 1145 PKADSEKMCIEIVSLAFCPEADVMSDETIQQVYVEYKFCDLPLSETETPMSLRKPRAGEEI---HFHFSKVIDLDPVEHQSRRQFLFAMLHAQDSDEGRFKFTVVSDPLDEEKKECQDIGYAYLELWQIFQSGKDILEQELEIVSPRNQAIQIGRLKVSLQAAAALHGIYKEM 1314
BLAST of NPHP8 vs. Ensembl Mouse
Match: Rpgrip1 (retinitis pigmentosa GTPase regulator interacting protein 1 [Source:MGI Symbol;Acc:MGI:1932134]) HSP 1 Score: 295.049 bits (754), Expect = 3.030e-81 Identity = 213/708 (30.08%), Postives = 357/708 (50.42%), Query Frame = 3
Query: 765 KSNLKDNLDMIRVTRDIKEK-------EIQVNVLHGKYEDLKTKQQ-YLERNNREMSDEIERLTSRLRSTDDFAGNAEGQIRNVTVLRKRINDLEATNNDFKKEIYLLKESNDKLTNDAFNTERERDWREKEMNYRAKIA--QLELTLKRDVSEKGGVLNKLESERDRVDNAEKEMSNLRLRNYELQAQIEELSDKLKFFSKEASLNPQEIEEALMIIQHKRNMVHAQST--PELDFIQKID-KNKDQ-DLTRKLLECEMNHAETIQELEKTRSLLRTQYKISNDYRQESEKISQRLDEIKKDYEERLTEYARLLDIRAARIHKLEA-----------QLKDIAYGTRNTQIETILEPDL--EPLAPE---------ILERGENILEIHIGRVCLTQQAVENIKDKDPFLFGTWDFYDFETQATGVLRGTSSEFDIKAEYLVKIDDFFLNYLYKNTFPFELHQATGAEYVTLAACQMSCKDIXXXXXXXXXXXXXXXNGLKYHCRAKLVGLRENSKDINFGVLEYWIRLKHPMDQVIRQYREKLKAEGYIMGNEMSVVEARR---------PIDSMNELIIRIIRCKGLKSRQKHLQPSPYIAYKFYDHSHHTSVTIPSSNSPEFHDLRRIPVQMNSDLHQYLKLQNLQIYVLDELDPDESVYLGVATIPLIQLCHNKNISGSFELHDNQHASNGTLEVELTWQHSYM 2753
++++K+N+++IR+ + ++E+ E Q+ + YEDL K Q L+ + ++ L + L A + Q+ +V++L+ + + + D +KE LL +S D+L + ++ + + ++ ++ QL + + + G L + + R + A ++ L+ ++ ++ Q E+ + L+ + AS +P+E+ E + AQ T P+ D + + K +D+ DL++ L E +++HAET ELEKTR +L Q KI+ Y++E E + D +D+EE+L LLD + +RI +LE QLKD+AYGT L P L EPLA +L EN+ E+H+ + LT A+ D P F T+ FYDFET T + G +D ++Y+V+ D L+YL + +LHQA +EY LA +S + + H A L G + + GVLEYW+RL P+ ++ ++ KA+ Y+ +SV+ AR+ NEL + I RC GL+SR+ QPSPY+ Y+F+ H ++ IP+S++P F D PV + SDL QYL+ + L +YV D+ DP+ YLG A +PL+ L NK+I G F L D+ SNG+++V+L W+ Y+
Sbjct: 228 RASIKENVELIRLKKLLQERNTSLAATEAQLTRVQEAYEDLLQKNQGILDTAHNAFLSQVNELKAELSEESKKAVSLRTQLGDVSILQITLKEFQVRVEDLEKERKLLSDSYDRLLENMLDSSHQPLDSSHQPHWSTELTGKQLPPQVCPLLDQMGTALEETKVFRQATNKAAQD-GKLKFQDTDILYQHEQEEESLQSTATVAS-SPEELCE-----------LAAQPTLLPQTDQRESSEPKAQDENDLSQVLSELQVSHAETTLELEKTRDMLLLQRKINMCYQEELEATLTKADRENRDHEEKLERLNHLLDFKNSRIKQLEGILRSHGLPTSEQLKDVAYGT--------LPPSLCLEPLAAHRGDDEVDMSLLHPSENLFELHVHQAFLTPAALTQAGDTQPTTFCTYSFYDFETHCTPLSTGPQPLYDFTSQYVVQADYLLLHYLQGTSVRLDLHQAMASEYHVLATGWISLDKVLGTVE-------------RVHGLATLAG----AGGEDLGVLEYWMRLCLPLKPSLQACNKRKKAQAYL---SVSVLGARKVQSNESRSETWAPQNELRVEITRCCGLRSRRLGRQPSPYVMYRFFTFPDHDTIIIPASSNPYFKDQALFPVLVTSDLDQYLRREALSVYVFDDEDPEPGSYLGRAQVPLLPLAQNKSIKGDFNLTDSGEKSNGSIKVQLDWKSHYL 894 HSP 2 Score: 77.411 bits (189), Expect = 1.280e-13 Identity = 49/173 (28.32%), Postives = 98/173 (56.65%), Query Frame = 3
Query: 3498 PELNPDEIVVEISSVEIADSADLLTDNNIKFIYVEYRLPGISLESTET-ISLQKPSVNQEIKKMNYNFKKTFDVSFNKNYMIRQHIATMLTEEPN--KYIVFTLVQEPTADSEADCEDIGTAKVNVKTLLKESRNLENERIPIYSYKNKSVXXXXXXXXXXXLGVLRAIEKEL 4007
P+ + +++ +EI S+ AD+++D I+ +YVEY+ + L TET +SL+KP +EI +++F K D+ ++ RQ + ML + + FT+V +P + + +C+DIG A + + + + +++ + + I S +N+++ IG + V++Q L I KE+
Sbjct: 1156 PKADSEKMCIEIVSLAFCPEADVMSDETIQQVYVEYKFCDLPLSETETPMSLRKPRAGEEI---HFHFSKVIDLDPVEHQSRRQFLFAMLHAQDSDEGRFKFTVVSDPLDEEKKECQDIGYAYLELWQIFQSGKDILEQELEIVSPRNQAIQIGRLKVSLQAAAALHGIYKEM 1325
BLAST of NPHP8 vs. Ensembl Mouse
Match: Rpgrip1 (retinitis pigmentosa GTPase regulator interacting protein 1 [Source:MGI Symbol;Acc:MGI:1932134]) HSP 1 Score: 155.992 bits (393), Expect = 1.021e-37 Identity = 76/196 (38.78%), Postives = 116/196 (59.18%), Query Frame = 3
Query: 2193 ENSKDINFGVLEYWIRLKHPMDQVIRQYREKLKAEGYIMGNEMSVVEARR---------PIDSMNELIIRIIRCKGLKSRQKHLQPSPYIAYKFYDHSHHTSVTIPSSNSPEFHDLRRIPVQMNSDLHQYLKLQNLQIYVLDELDPDESVYLGVATIPLIQLCHNKNISGSFELHDNQHASNGTLEVELTWQHSYM 2753
E + + GVLEYW+RL P+ ++ ++ KA+ Y+ +SV+ AR+ NEL + I RC GL+SR+ QPSPY+ Y+F+ H ++ IP+S++P F D PV + SDL QYL+ + L +YV D+ DP+ YLG A +PL+ L NK+I G F L D+ SNG+++V+L W+ Y+
Sbjct: 540 EGAGGEDLGVLEYWMRLCLPLKPSLQACNKRKKAQAYL---SVSVLGARKVQSNESRSETWAPQNELRVEITRCCGLRSRRLGRQPSPYVMYRFFTFPDHDTIIIPASSNPYFKDQALFPVLVTSDLDQYLRREALSVYVFDDEDPEPGSYLGRAQVPLLPLAQNKSIKGDFNLTDSGEKSNGSIKVQLDWKSHYL 732 HSP 2 Score: 77.411 bits (189), Expect = 1.136e-13 Identity = 49/173 (28.32%), Postives = 98/173 (56.65%), Query Frame = 3
Query: 3498 PELNPDEIVVEISSVEIADSADLLTDNNIKFIYVEYRLPGISLESTET-ISLQKPSVNQEIKKMNYNFKKTFDVSFNKNYMIRQHIATMLTEEPN--KYIVFTLVQEPTADSEADCEDIGTAKVNVKTLLKESRNLENERIPIYSYKNKSVXXXXXXXXXXXLGVLRAIEKEL 4007
P+ + +++ +EI S+ AD+++D I+ +YVEY+ + L TET +SL+KP +EI +++F K D+ ++ RQ + ML + + FT+V +P + + +C+DIG A + + + + +++ + + I S +N+++ IG + V++Q L I KE+
Sbjct: 952 PKADSEKMCIEIVSLAFCPEADVMSDETIQQVYVEYKFCDLPLSETETPMSLRKPRAGEEI---HFHFSKVIDLDPVEHQSRRQFLFAMLHAQDSDEGRFKFTVVSDPLDEEKKECQDIGYAYLELWQIFQSGKDILEQELEIVSPRNQAIQIGRLKVSLQAAAALHGIYKEM 1121 HSP 3 Score: 77.411 bits (189), Expect = 1.312e-13 Identity = 83/327 (25.38%), Postives = 166/327 (50.76%), Query Frame = 3
Query: 765 KSNLKDNLDMIRVTRDIKEK-------EIQVNVLHGKYEDLKTKQQ-YLERNNREMSDEIERLTSRLRSTDDFAGNAEGQIRNVTVLRKRINDLEATNNDFKKEIYLLKESNDKLTNDAFNTERERDWREKEMNYRAKIA--QLELTLKRDVSEKGGVLNKLESERDRVDNAEKEMSNLRLRNYELQAQIEELSDKLKFFSKEASLNPQEIEEALMIIQHKRNMVHAQST--PELDFIQKID-KNKDQ-DLTRKLLECEMNHAETIQELEKTRSLLRTQYKISNDYRQESEKISQRLDEIKKDYEERLTEYARLLDIRAARIHKLEA 1703
++++K+N+++IR+ + ++E+ E Q+ + YEDL K Q L+ + ++ L + L A + Q+ +V++L+ + + + D +KE LL +S D+L + ++ + + ++ ++ QL + + + G L + + R + A ++ L+ ++ ++ Q E+ + L+ + AS +P+E+ E + AQ T P+ D + + K +D+ DL++ L E +++HAET ELEKTR +L Q KI+ Y++E E + D +D+EE+L LLD + +RI +LE
Sbjct: 228 RASIKENVELIRLKKLLQERNTSLAATEAQLTRVQEAYEDLLQKNQGILDTAHNAFLSQVNELKAELSEESKKAVSLRTQLGDVSILQITLKEFQVRVEDLEKERKLLSDSYDRLLENMLDSSHQPLDSSHQPHWSTELTGKQLPPQVCPLLDQMGTALEETKVFRQATNKAAQD-GKLKFQDTDILYQHEQEEESLQSTATVAS-SPEELCE-----------LAAQPTLLPQTDQRESSEPKAQDENDLSQVLSELQVSHAETTLELEKTRDMLLLQRKINMCYQEELEATLTKADRENRDHEEKLERLNHLLDFKNSRIKQLEG 541
BLAST of NPHP8 vs. Ensembl Mouse
Match: Rpgrip1l (Rpgrip1-like [Source:MGI Symbol;Acc:MGI:1920563]) HSP 1 Score: 97.0561 bits (240), Expect = 1.047e-21 Identity = 44/101 (43.56%), Postives = 64/101 (63.37%), Query Frame = 3
Query: 1800 GENILEIHIGRVCLTQQAVENIKDKDPFLFGTWDFYDFETQATGVLRGTSSEFDIKAEYLVKIDDFFLNYLYKNTFPFELHQATGAEYVTLAACQMSCKDI 2102
GEN+ EIHI +V + + + DK+ F T+ FYDFE Q T ++RG E++ ++YLV ++D FL Y+ KNT ELHQA +Y T+AACQ+ +I
Sbjct: 1 GENLFEIHINKVTFSSEVLRASGDKELVTFCTYAFYDFELQTTPIVRGLYPEYNFTSQYLVHVNDLFLQYIQKNTVTLELHQAHSTDYETIAACQLRFHEI 101
BLAST of NPHP8 vs. UniProt/SwissProt
Match: sp|Q68CZ1|FTM_HUMAN (Protein fantom OS=Homo sapiens OX=9606 GN=RPGRIP1L PE=1 SV=2) HSP 1 Score: 537.724 bits (1384), Expect = 1.183e-166 Identity = 340/913 (37.24%), Postives = 531/913 (58.16%), Query Frame = 3
Query: 177 RKTISQWTKDYLEDKYLRLQDDHETLKKHARLQEXXXXXXXXXXXXXXSDAKKNGDIT--PK--------TDDFEEFRRKCSILESQNGLLKDKVKLLQSQLLAQGKKASVYDNVPSRIKSGAIERSNSIQNSGRKNNIR-VIKPRGELYPLSPRRDESVTGDQSLISLNKVVEDLK--YEVHRLQIEN----EELLKKAYRREDEKL----------SPEHYKSNLKDNLDMIRVTRDIKEKEIQVNVLHGKYEDLKTKQQYLERNNREMSDEIERLTSRLRSTDDFAGNAEGQIRNVTVLRKRINDLEATNNDFKKEIYLLKESNDKLTNDAFNTERERDWREKEMNYRAKIAQLELTLKRDVSEKGGVLNKLESERDRVDNAEKEMSNLRLRNYELQAQIEELSDKLKFFSKEASLNPQEIEEALMIIQHKRNMVHAQSTPELDFIQKIDKNKDQDLTRKLLECEMNHAETIQELEKTRSLLRTQYKISNDYRQESEKISQRLDEIKKDYEERLTEYARLLDIRAARIHKLEAQLKDIAYGTRNTQIETILEPD--LEPLAPEI-LERGENILEIHIGRVCLTQQAVENIKDKDPFLFGTWDFYDFETQATGVLRGTSSEFDIKAEYLVKIDDFFLNYLYKNTFPFELHQATGAEYVTLAACQMSCKDIXXXXXXXXXXXXXXXNGLKYHCRAKLVGLRENSKDI-NFGVLEYWIRLKHPMDQVIRQYREKLKAEGYIMGN-----EMSVVEARRP-------IDS----MNELIIRIIRCKGLKSRQKHLQPSPYIAYKFYDHSHHTSVTIPSSNSPEFHDLRRIPVQMNSDLHQYLKLQNLQIYVLDELDPDESVYLGVATIPLIQLCHNKNISGSFELHDNQHASNGTLEVELTWQHSYMYQDNSFT 2774
R+ +S+ +++ LED++LRL D++ LK+HAR QE KIK++ TKL+++ +D K+ + PK + E+ + K LE QN LK+++ + QL QG + + Y+NV SRI +G R + +N+G + R IK + +P + G+ L + +L+ + R QIE E+LK RR++ ++ +SN++DN++MI++ + + EK ++ + GK+ L+ KQ+ L ++ + + L +L+ + E Q+ ++ +RI +L+ ND +KE LLKE+ DKL + AF+ E W+ KE + +IAQLE LK D+++K +L++L++ERD+ + +E L+L+ E + Q++EL ++K +++E +N E+ EAL++I+ ++ Q +L F+ K+D ++DL R + E + HAET+QELEKTR++L Q+KI+ DY+ E E ++++++ +++DYE ++ +Y LLDIRAARIHKLEAQLKDIAYGT+ + + + PD ++ I LERGEN+ EIHI +V + + ++ DK+P F T+ FYDFE Q T V+RG E++ ++YLV ++D FL Y+ KNT E+HQA EY T+AACQ+ +I EKS + C A L+G + DI NFG +EYW RL+ PMDQ IR YRE+ KA GYI N M + + P DS +NEL I I C L+SR HLQP PY+ YKF+D + H + IPSSN P+F D PV MN DL +YLK ++L YV D+ D E++Y+G +PLI L H++ ISG FEL D+Q GT+ V L W+ +Y+ S T
Sbjct: 39 RQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTG---RRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKE----QKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHLERGENLFEIHINKVTFSSEVLQASGDKEPVTFCTYAFYDFELQTTPVVRGLHPEYNFTSQYLVHVNDLFLQYIQKNTITLEVHQAYSTEYETIAACQLKFHEILEKSG-------------RIFCTASLIGTK---GDIPNFGTVEYWFRLRVPMDQAIRLYRERAKALGYITSNFKGPEHMQSLSQQAPKTAQLSSTDSTDGNLNELHITIRCCNHLQSRASHLQPHPYVVYKFFDFADHDTAIIPSSNDPQFDDHMYFPVPMNMDLDRYLKSESLSFYVFDDSDTQENIYIGKVNVPLISLAHDRCISGIFELTDHQKHPAGTIHVILKWKFAYLPPSGSIT 928 HSP 2 Score: 59.6918 bits (143), Expect = 2.063e-7 Identity = 42/139 (30.22%), Postives = 73/139 (52.52%), Query Frame = 3
Query: 3513 DEIVVEISSVEIADSADLLTDNNIKFIYVEYRLPGISLESTETISLQKPSVNQEIKKMNYNFKKTFDVSFNKNYMIRQHIATMLT--EEPNKYIVFTLVQEPTADSE-ADCEDIGTAKVNVKTLLKESRNLENERIPIY 3920
++I +EI ++ + DS + D+ I+ ++VE R + E T +SL KP Q + YN+ V N R + +L E PN+ + FT+V +P D + +CEDIG A V++ + +E R+L + I ++
Sbjct: 1147 EKIRIEIIALSLNDS-QVTMDDTIQRLFVECRFYSLPAEET-PVSLPKPKSGQWVY---YNYSNVIYVDKENNKAKRDILKAILQKQEMPNRSLRFTVVSDPPEDEQDLECEDIGVAHVDLADMFQEGRDLIEQNIDVF 1280
BLAST of NPHP8 vs. UniProt/SwissProt
Match: sp|Q8CG73|FTM_MOUSE (Protein fantom OS=Mus musculus OX=10090 GN=Rpgrip1l PE=1 SV=2) HSP 1 Score: 521.161 bits (1341), Expect = 5.806e-161 Identity = 330/910 (36.26%), Postives = 531/910 (58.35%), Query Frame = 3
Query: 177 RKTISQWTKDYLEDKYLRLQDDHETLKKHARLQEXXXXXXXXXXXXXXSDAKKNGDIT--PKT--------DDFEEFRRKCSILESQNGLLKDKVKLLQSQLLAQGKKASVYDNVPSRIKSG---AIERSNSIQNSGRKNNIRVIKPRGELYPLSPRRDESVTGDQ--SLISLNKVVEDLKYEVHRLQIENEELLKKAYRREDE-KLS--------PEHYKSNLKDNLDMIRVTRDIKEKEIQVNVLHGKYEDLKTKQQYLERNNREMSDEIERLTSRLRSTDDFAGNAEGQIRNVTVLRKRINDLEATNNDFKKEIYLLKESNDKLTNDAFNTERERDWREKEMNYRAKIAQLELTLKRDVSEKGGVLNKLESERDRVDNAEKEMSNLRLRNYELQAQIEELSDKLKFFSKEASLNPQEIEEALMIIQHKRNMVHAQSTPELDFIQKIDKNKDQDLTRKLLECEMNHAETIQELEKTRSLLRTQYKISNDYRQESEKISQRLDEIKKDYEERLTEYARLLDIRAARIHKLEAQLKDIAYGTRNTQIETILEPD--LEPLAPEI-LERGENILEIHIGRVCLTQQAVENIKDKDPFLFGTWDFYDFETQATGVLRGTSSEFDIKAEYLVKIDDFFLNYLYKNTFPFELHQATGAEYVTLAACQMSCKDIXXXXXXXXXXXXXXXNGLKYHCRAKLVGLRENSKDI-NFGVLEYWIRLKHPMDQVIRQYREKLKAEGYIMGN-------EMSVVEAR-----RPIDS----MNELIIRIIRCKGLKSRQKHLQPSPYIAYKFYDHSHHTSVTIPSSNSPEFHDLRRIPVQMNSDLHQYLKLQNLQIYVLDELDPDESVYLGVATIPLIQLCHNKNISGSFELHDNQHASNGTLEVELTWQHSYMYQDNSFT 2774
R+ +S+ +++ LED++LRL D++ LK+HAR QE KIK++ TKL+++ +D K+ + PK + E+ + K LE QN +LK+++ + QL QG + + Y V +R+ +G A + S + G+ + + + P + S+ + + +L V++ + ++ L+ E L + R+E+E +LS +SN++DN++ I++ + + EK ++V+ GK+ L+ KQ+ L ++ + + L +L+ + E Q+ +V +R+ +L+ ND +KE LLKE+ DKL N AF+ E W+ KE + +IAQLE LK D+++K VL+KL++ERD+ + +E +L+L+ + + ++ EL +LKFF++E+ +N ++ EAL++I+ ++ Q +L F++K+D ++DL R + E + HAET+QELEKTR++L Q+KI+ DY+ E E ++Q+++ +++DYE ++ +Y LLDIRAARI KLEAQLKDIAYGT+ + + + PD ++ I LERGEN+ EIHI +V + + + DK+ F T+ FYDFE Q T ++RG E++ ++YLV ++D FL Y+ KNT ELHQA +Y T+AACQ+ +I EKS + C LVG + DI NFG +EYW RL+ PMDQ IR YRE+ KA GYI N ++S +A P +S +NEL + + C GL+SR +LQP Y+ YKF+D H + +PSSN P+F D PV MN DL +YLK ++L YV D+ D E++Y+G +PLI L H+K ISG FEL D + + GT++V L W+ +Y+ S T
Sbjct: 39 RQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELERQNEVLKNRLISAKQQLQVQGHRQTSYSRVQARVNTGRRRASASAGSQECPGKGLRFQNVDEAETVQPTLTKYSNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLKRKENEIELSLLQLREQQATDQRSNIRDNVETIKLHKQLVEKSNALSVIEGKFIQLQEKQRTLRISHDALMANGDELNKQLKEQRLKCCSLEKQLHSVRFSERRVEELQDRINDLEKERELLKENYDKLYNSAFSAAHEEQWKLKEQQMKVQIAQLETALKSDLTDKTEVLDKLKTERDQNEKLVQENRDLQLQCLQQKQRLHELQSRLKFFNQESDINADDLSEALLLIKAQKE----QKNGDLSFLEKVDSKINKDLDRSMKELQATHAETVQELEKTRNMLIMQHKINKDYQMEVETVTQKMENLQQDYELKVEQYVHLLDIRAARIQKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHLERGENLFEIHINKVTFSSEVLRASGDKELVTFCTYAFYDFELQTTPIVRGLYPEYNFTSQYLVHVNDLFLQYIQKNTVTLELHQAHSTDYETIAACQLRFHEILEKSG-------------RIFCTTSLVGTK---GDIPNFGTVEYWFRLRVPMDQAIRLYRERAKALGYITSNFKKPEKMQLSSQQAATTAQISPAESTDGNLNELHVTVKCCTGLQSRASYLQPHAYVVYKFFDFPDHDTAIVPSSNDPQFDDHMCFPVPMNMDLDRYLKSESLSFYVFDDSDTQENIYMGKVNVPLISLAHDKCISGIFELMDKEKHAAGTIQVILKWKFTYLPPSGSIT 928
BLAST of NPHP8 vs. UniProt/SwissProt
Match: sp|Q9GLM3|RPGR1_BOVIN (X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 OS=Bos taurus OX=9913 GN=RPGRIP1 PE=1 SV=1) HSP 1 Score: 327.791 bits (839), Expect = 8.071e-92 Identity = 223/701 (31.81%), Postives = 363/701 (51.78%), Query Frame = 3
Query: 765 KSNLKDNLDMIRVTRDIKEK-------EIQVNVLHGKYEDLKTKQQ-YLERNNREMSDEIERLTSRLRSTDDFAGNAEGQIRNVTVLRKRINDLEATNNDFKKEIYLLKESNDKLTNDAFNTERERDW-REKEMNYRAKIAQLELTLKRDVSEKGGVLNKLESERDRVDNAEKEMSNLRLRNYELQAQIEELSD--KLKFFSKEASLNPQEIEEALMIIQHKRNMVHAQSTPELDFIQKID-KNKDQD-LTRKLLECEMNHAETIQELEKTRSLLRTQYKISNDYRQESEKISQRLDEIKKDYEERLTEYARLLDIRAARIHKLEAQLKDIAYGTRNTQIETILEP----------DLEPLAPEILERGENILEIHIGRVCLTQQAVENIKDKDPFLFGTWDFYDFETQATGVLRGTSSEFDIKAEYLVKIDDFFLNYLYKNTFPFELHQATGAEYVTLAACQMSCKDIXXXXXXXXXXXXXXXNGLKYHCRAKLVGLRENSKDINFGVLEYWIRLKHPMDQVIRQYREKLKAEGYIMGNEMSVVEARR------PIDSMNELIIRIIRCKGLKSRQKHLQPSPYIAYKFYDHSHHTSVTIPSSNSPEFHDLRRIPVQMNSDLHQYLKLQNLQIYVLDELDPDESVYLGVATIPLIQLCHNKNISGSFELHDNQHASNGTLEVELTWQHSYMYQDNSFTKP 2780
++++K+N+ +IR+ + + E+ + Q+ + YE L K Q L + + ++ L + L+ A + + Q+ +V++L+ + + + D +KE LL ++ DKL ++ + W E + K++QL+ L ++ EK +L +L E+ + + E E+++L LQ +E+ D + FS+ + H E IQ + KN+++ L++ L E +++HAET ELEKTR +L Q KI+ Y++E E + + D KD+E +L +LLD++ RI++LE QLKD+AYGTR Q+ L+P D+ P + EN+ E+HI + LT A+ D P F T+ FYDFET T ++ G +D ++Y+V+ID FL+YL + +LHQA +E+ TLAA + C D ++ + H A L G + FGVLEYW+RL+ P+ ++ Y ++ KA+ Y+ N + EA++ + NEL + IIRC GL+SR QPSPY+ Y+F+ S H + IP+S++P F DL R PV + SDL QYL+ + L +YV D+ D + YLG +PL+ L NK+I G F L D NG+++V L W Y+ +N F KP
Sbjct: 219 RASIKENIQLIRLKKLLHERNTSLAVTKAQLTEVQAAYETLLHKNQGILGAAHNALLSQVNELRAELKEESKKAVSLKSQMEDVSILQITLKEFQERVEDLEKERKLLNDNYDKLLESMLDSSNQPQWSHELGEQLQQKVSQLQDQLDVEMKEKREILLQLSQEKAQNKDLELEVTSL------LQKHKQEVEDLQNISTFSQSPD-------------RQSAPATHPALFQETIQIQPCEPKNQEEKKLSQMLSELQVSHAETTLELEKTRDMLILQRKINVCYQEELEAMMTKADNENKDHEAKLERLNQLLDLKNKRINQLEEQLKDVAYGTR--QLPLCLKPLPAHENEDKVDISPW-----HQSENLFELHIHQAFLTSAALAQAGDTQPTTFCTYSFYDFETHCTPLVVGPQPLYDFTSQYVVEIDSLFLHYLQGASAQLDLHQAIASEHHTLAAGWI-CFDRVLETVE------------RVHGSATLTG----TGGEVFGVLEYWMRLRFPIRSSLQAYNKRKKAQAYLAANVLGAWEAQKDEPRSGTWKNQNELRVEIIRCCGLRSRSLGAQPSPYVMYRFFTFSDHDTTIIPASSNPYFRDLARFPVLVTSDLDQYLRREALSVYVFDDEDSEPGSYLGRVQVPLLPLAQNKSIQGDFNLTDPVGEPNGSVQVHLDWGSCYLPPEN-FPKP 875 HSP 2 Score: 72.0182 bits (175), Expect = 3.481e-11 Identity = 41/136 (30.15%), Postives = 80/136 (58.82%), Query Frame = 3
Query: 3498 PELNPDEIVVEISSVEIADSADLLTDNNIKFIYVEYRLPGISLESTET-ISLQKPSVNQEIKKMNYNFKKTFDVSFNKNYMIRQHIATML-TEEPNK-YIVFTLVQEPTADSEADCEDIGTAKVNVKTLLKESRNL 3896
P+ + +++ +EI S+ A+++ D N++ +YVEYR + L TET +SL+KP +EI ++F K D+ + RQ + TML E+P + ++ FT+V +P + + +C+++G A + + +L R++
Sbjct: 1046 PKADSEKMCIEIVSLAFYPEAEVMCDENVEQVYVEYRFYDLPLSETETPVSLRKPRAGEEI---YFHFSKVIDLDPVEQKERRQFLFTMLIGEDPEQGHLKFTVVSDPIEEEKKECQEVGYAYLELWPMLVSGRDI 1178
BLAST of NPHP8 vs. UniProt/SwissProt
Match: sp|Q9EPQ2|RPGR1_MOUSE (X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 OS=Mus musculus OX=10090 GN=Rpgrip1 PE=1 SV=1) HSP 1 Score: 295.049 bits (754), Expect = 2.119e-80 Identity = 213/708 (30.08%), Postives = 357/708 (50.42%), Query Frame = 3
Query: 765 KSNLKDNLDMIRVTRDIKEK-------EIQVNVLHGKYEDLKTKQQ-YLERNNREMSDEIERLTSRLRSTDDFAGNAEGQIRNVTVLRKRINDLEATNNDFKKEIYLLKESNDKLTNDAFNTERERDWREKEMNYRAKIA--QLELTLKRDVSEKGGVLNKLESERDRVDNAEKEMSNLRLRNYELQAQIEELSDKLKFFSKEASLNPQEIEEALMIIQHKRNMVHAQST--PELDFIQKID-KNKDQ-DLTRKLLECEMNHAETIQELEKTRSLLRTQYKISNDYRQESEKISQRLDEIKKDYEERLTEYARLLDIRAARIHKLEA-----------QLKDIAYGTRNTQIETILEPDL--EPLAPE---------ILERGENILEIHIGRVCLTQQAVENIKDKDPFLFGTWDFYDFETQATGVLRGTSSEFDIKAEYLVKIDDFFLNYLYKNTFPFELHQATGAEYVTLAACQMSCKDIXXXXXXXXXXXXXXXNGLKYHCRAKLVGLRENSKDINFGVLEYWIRLKHPMDQVIRQYREKLKAEGYIMGNEMSVVEARR---------PIDSMNELIIRIIRCKGLKSRQKHLQPSPYIAYKFYDHSHHTSVTIPSSNSPEFHDLRRIPVQMNSDLHQYLKLQNLQIYVLDELDPDESVYLGVATIPLIQLCHNKNISGSFELHDNQHASNGTLEVELTWQHSYM 2753
++++K+N+++IR+ + ++E+ E Q+ + YEDL K Q L+ + ++ L + L A + Q+ +V++L+ + + + D +KE LL +S D+L + ++ + + ++ ++ QL + + + G L + + R + A ++ L+ ++ ++ Q E+ + L+ + AS +P+E+ E + AQ T P+ D + + K +D+ DL++ L E +++HAET ELEKTR +L Q KI+ Y++E E + D +D+EE+L LLD + +RI +LE QLKD+AYGT L P L EPLA +L EN+ E+H+ + LT A+ D P F T+ FYDFET T + G +D ++Y+V+ D L+YL + +LHQA +EY LA +S + + H A L G + + GVLEYW+RL P+ ++ ++ KA+ Y+ +SV+ AR+ NEL + I RC GL+SR+ QPSPY+ Y+F+ H ++ IP+S++P F D PV + SDL QYL+ + L +YV D+ DP+ YLG A +PL+ L NK+I G F L D+ SNG+++V+L W+ Y+
Sbjct: 228 RASIKENVELIRLKKLLQERNTSLAATEAQLTRVQEAYEDLLQKNQGILDTAHNAFLSQVNELKAELSEESKKAVSLRTQLGDVSILQITLKEFQVRVEDLEKERKLLSDSYDRLLENMLDSSHQPLDSSHQPHWSTELTGKQLPPQVCPLLDQMGTALEETKVFRQATNKAAQD-GKLKFQDTDILYQHEQEEESLQSTATVAS-SPEELCE-----------LAAQPTLLPQTDQRESSEPKAQDENDLSQVLSELQVSHAETTLELEKTRDMLLLQRKINMCYQEELEATLTKADRENRDHEEKLERLNHLLDFKNSRIKQLEGILRSHGLPTSEQLKDVAYGT--------LPPSLCLEPLAAHRGDDEVDMSLLHPSENLFELHVHQAFLTPAALTQAGDTQPTTFCTYSFYDFETHCTPLSTGPQPLYDFTSQYVVQADYLLLHYLQGTSVRLDLHQAMASEYHVLATGWISLDKVLGTVE-------------RVHGLATLAG----AGGEDLGVLEYWMRLCLPLKPSLQACNKRKKAQAYL---SVSVLGARKVQSNESRSETWAPQNELRVEITRCCGLRSRRLGRQPSPYVMYRFFTFPDHDTIIIPASSNPYFKDQALFPVLVTSDLDQYLRREALSVYVFDDEDPEPGSYLGRAQVPLLPLAQNKSIKGDFNLTDSGEKSNGSIKVQLDWKSHYL 894 HSP 2 Score: 77.411 bits (189), Expect = 8.956e-13 Identity = 49/173 (28.32%), Postives = 98/173 (56.65%), Query Frame = 3
Query: 3498 PELNPDEIVVEISSVEIADSADLLTDNNIKFIYVEYRLPGISLESTET-ISLQKPSVNQEIKKMNYNFKKTFDVSFNKNYMIRQHIATMLTEEPN--KYIVFTLVQEPTADSEADCEDIGTAKVNVKTLLKESRNLENERIPIYSYKNKSVXXXXXXXXXXXLGVLRAIEKEL 4007
P+ + +++ +EI S+ AD+++D I+ +YVEY+ + L TET +SL+KP +EI +++F K D+ ++ RQ + ML + + FT+V +P + + +C+DIG A + + + + +++ + + I S +N+++ IG + V++Q L I KE+
Sbjct: 1156 PKADSEKMCIEIVSLAFCPEADVMSDETIQQVYVEYKFCDLPLSETETPMSLRKPRAGEEI---HFHFSKVIDLDPVEHQSRRQFLFAMLHAQDSDEGRFKFTVVSDPLDEEKKECQDIGYAYLELWQIFQSGKDILEQELEIVSPRNQAIQIGRLKVSLQAAAALHGIYKEM 1325
BLAST of NPHP8 vs. UniProt/SwissProt
Match: sp|Q96KN7|RPGR1_HUMAN (X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 OS=Homo sapiens OX=9606 GN=RPGRIP1 PE=1 SV=2) HSP 1 Score: 281.182 bits (718), Expect = 4.074e-76 Identity = 212/711 (29.82%), Postives = 365/711 (51.34%), Query Frame = 3
Query: 765 KSNLKDNLDMIRVTRDIKEK-------EIQVNVLHGKYEDLKTKQQ-YLERNNREMSDEIERLTSRLRSTDDFAGNAEGQIRNVTVLRKRINDLEATNNDFKKEIYLLKESNDKLTNDAFNTER---ERDWREKEMNYRAKIAQLELTLKRD--VSEKGGVLNKLESERDRVDNAEKEMSNLRLRNYE----LQ--AQIEELSDKLKFFSKEASLNPQEIEEALMIIQHKRNMVHAQSTPELDFIQKIDKNKDQDLTRKLLECEMNHAETIQELEKTRSLLRTQYKISNDYRQESEKISQRLDEIKKDYEERLTEYARLLDIRAARIHKLEA-----------QLKDIAYGTR--NTQIETI-LEPDLEPLAPEILERGENILEIHIGRVCLTQQAVENIKDKDPFLFGTWDFYDFETQATGVLRGTSSEFDIKAEYLVKIDDFFLNYLYKNTFPFELHQATGAEYVTLAACQMSCKDIXXXXXXXXXXXXXXXNGLKYHCRAKLVGLRENSKDINFGVLEYWIRLKHPMDQVIRQYREKLKAEGY----IMGNEMSVVEARRP--IDSMNELIIRIIRCKGLKSRQKHLQPSPYIAYKFYDHSHHTSVTIPSSNSPEFHDLRRIPVQMNSDLHQYLKLQNLQIYVLDELDPDESVYLGVATIPLIQLCHNKNISGSFELHDNQHASNGTLEVELTWQHSYMYQDNSFTKP 2780
++++K+ +++IR+ + + E+ + Q+ + YE L K Q L + + ++ L + L+ A + + Q+ +V++L+ + + + D +KE LL ++ DKL ++ + W + + + + +L + D + +K VL +L E+ + ++ + E++N+ ++ + LQ A I + D+ E + +P ++E I S P+ +++ L++ L E +++HAET ELEKTR +L Q KI+ Y++E E + + D +D++E+L RLLD++ RI +LE QLKD+AYGTR + +ET+ D + + +L +GEN+ E+HI + LT A+ D P F T+ FYDFET T + G +D ++Y+++ D FL+YL + + ++HQA +E+ TLAA + C D ++ K H A L+G + FGVLEYW+RL+ P+ ++ ++ KA+ Y ++G + E R + NEL I I +C GL+SR QPSPY Y+F+ S H + IP+SN+P F D R PV + SDL YL+ + L I+V D+ D + YLG A +PL+ L N++I G F L D NG+++V+L W+ Y+ + SF KP
Sbjct: 267 RASIKEKVELIRLKKLLHERNASLVMTKAQLTEVQEAYETLLQKNQGILSAAHEALLKQVNELRAELKEESKKAVSLKSQLEDVSILQMTLKEFQERVEDLEKERKLLNDNYDKLLESMLDSSDSSSQPHWSNELIAEQLQQQVSQLQDQLDAELEDKRKVLLELSREKAQNEDLKLEVTNILQKHKQEVELLQNAATISQPPDR----QSEPATHPAVLQENTQI---------EPSEPK--------NQEEKKLSQVLNELQVSHAETTLELEKTRDMLILQRKINVCYQEELEAMMTKADNDNRDHKEKLERLTRLLDLKNNRIKQLEGILRSHDLPTSEQLKDVAYGTRPLSLCLETLPAHGDEDKVDISLLHQGENLFELHIHQAFLTSAALAQAGDTQPTTFCTYSFYDFETHCTPLSVGPQPLYDFTSQYVMETDSLFLHYLQEASARLDIHQAMASEHSTLAAGWI-CFDRVLETVE------------KVHGLATLIG----AGGEEFGVLEYWMRLRFPIKPSLQACNKRKKAQVYLSTDVLGGRKAQEEEFRSESWEPQNELWIEITKCCGLRSRWLGTQPSPYAVYRFFTFSDHDTAIIPASNNPYFRDQARFPVLVTSDLDHYLRREALSIHVFDDEDLEPGSYLGRARVPLLPLAKNESIKGDFNLTDPAEKPNGSIQVQLDWKFPYIPPE-SFLKP 938 HSP 2 Score: 78.9518 bits (193), Expect = 3.375e-13 Identity = 52/173 (30.06%), Postives = 104/173 (60.12%), Query Frame = 3
Query: 3498 PELNPDEIVVEISSVEIADSADLLTDNNIKFIYVEYRLPGISLESTET-ISLQKPSVNQEIKKMNYNFKKTFDVSFNKNYMIRQHIATMLT-EEPNK-YIVFTLVQEPTADSEADCEDIGTAKVNVKTLLKESRNLENERIPIYSYKNKSVXXXXXXXXXXXLGVLRAIEKEL 4007
P+ + +++ +EI S+ A++++D NIK +YVEY+ + L TET +SL+KP +EI +++F K D+ + R+ + ML ++P++ ++ FT+V +P + + +CE++G A + + +L+ R++ + + I S ++ + IG + V++Q VL AI KE+
Sbjct: 1111 PKADSEKMCIEIVSLAFYPEAEVMSDENIKQVYVEYKFYDLPLSETETPVSLRKPRAGEEI---HFHFSKVIDLDPQEQQGRRRFLFDMLNGQDPDQGHLKFTVVSDPLDEEKKECEEVGYAYLQLWQILESGRDILEQELDIVSPEDLATPIGRLKVSLQAAAVLHAIYKEM 1280
BLAST of NPHP8 vs. TrEMBL
Match: A0A0H3YJP0 (NPHP8 OS=Schmidtea mediterranea OX=79327 GN=NPHP8 PE=2 SV=1) HSP 1 Score: 2508.79 bits (6501), Expect = 0.000e+0 Identity = 1320/1320 (100.00%), Postives = 1320/1320 (100.00%), Query Frame = 3
Query: 54 MNLQYQAPNTPNSARYKSQDLYSDSNTDLNAVIPKMDLAQERKTISQWTKDYLEDKYLRLQDDHETLKKHARLQEXXXXXXXXXXXXXXSDAKKNGDITPKTDDFEEFRRKCSILESQNGLLKDKVKLLQSQLLAQGKKASVYDNVPSRIKSGAIERSNSIQNSGRKNNIRVIKPRGELYPLSPRRDESVTGDQSLISLNKVVEDLKYEVHRLQIENEELLKKAYRREDEKLSPEHYKSNLKDNLDMIRVTRDIKEKEIQVNVLHGKYEDLKTKQQYLERNNREMSDEIERLTSRLRSTDDFAGNAEGQIRNVTVLRKRINDLEATNNDFKKEIYLLKESNDKLTNDAFNTERERDWREKEMNYRAKIAQLELTLKRDVSEKGGVLNKLESERDRVDNAEKEMSNLRLRNYELQAQIEELSDKLKFFSKEASLNPQEIEEALMIIQHKRNMVHAQSTPELDFIQKIDKNKDQDLTRKLLECEMNHAETIQELEKTRSLLRTQYKISNDYRQESEKISQRLDEIKKDYEERLTEYARLLDIRAARIHKLEAQLKDIAYGTRNTQIETILEPDLEPLAPEILERGENILEIHIGRVCLTQQAVENIKDKDPFLFGTWDFYDFETQATGVLRGTSSEFDIKAEYLVKIDDFFLNYLYKNTFPFELHQATGAEYVTLAACQMSCKDIXXXXXXXXXXXXXXXNGLKYHCRAKLVGLRENSKDINFGVLEYWIRLKHPMDQVIRQYREKLKAEGYIMGNEMSVVEARRPIDSMNELIIRIIRCKGLKSRQKHLQPSPYIAYKFYDHSHHTSVTIPSSNSPEFHDLRRIPVQMNSDLHQYLKLQNLQIYVLDELDPDESVYLGVATIPLIQLCHNKNISGSFELHDNQHASNGTLEVELTWQHSYMYQDNSFTKPINSVALLPGEEGIKNENQPSRHTAPVKEETKDQPDAADYSKQIPNATPKEIRTPKKKERQKKPNQEVMDSGLMSPPAVQIVKGILKNRENIQPEKSLSESLKDKDVLEALIMPDLQIKDDSPIESTKSALEEDIKPTSSLERSREIXXXXXXXXXXXXXSTIDDTVLTKPNTEESKPISSNKVSQPNTYESEXXXXXXXXXXXXXXXLVNDPASGTNNILSENXXXXXXXXXXXXSPIKPELNPDEIVVEISSVEIADSADLLTDNNIKFIYVEYRLPGISLESTETISLQKPSVNQEIKKMNYNFKKTFDVSFNKNYMIRQHIATMLTEEPNKYIVFTLVQEPTADSEADCEDIGTAKVNVKTLLKESRNLENERIPIYSYKNKSVXXXXXXXXXXXLGVLRAIEKELKT 4013
MNLQYQAPNTPNSARYKSQDLYSDSNTDLNAVIPKMDLAQERKTISQWTKDYLEDKYLRLQDDHETLKKHARLQELKIKKLGTKLLKITSDAKKNGDITPKTDDFEEFRRKCSILESQNGLLKDKVKLLQSQLLAQGKKASVYDNVPSRIKSGAIERSNSIQNSGRKNNIRVIKPRGELYPLSPRRDESVTGDQSLISLNKVVEDLKYEVHRLQIENEELLKKAYRREDEKLSPEHYKSNLKDNLDMIRVTRDIKEKEIQVNVLHGKYEDLKTKQQYLERNNREMSDEIERLTSRLRSTDDFAGNAEGQIRNVTVLRKRINDLEATNNDFKKEIYLLKESNDKLTNDAFNTERERDWREKEMNYRAKIAQLELTLKRDVSEKGGVLNKLESERDRVDNAEKEMSNLRLRNYELQAQIEELSDKLKFFSKEASLNPQEIEEALMIIQHKRNMVHAQSTPELDFIQKIDKNKDQDLTRKLLECEMNHAETIQELEKTRSLLRTQYKISNDYRQESEKISQRLDEIKKDYEERLTEYARLLDIRAARIHKLEAQLKDIAYGTRNTQIETILEPDLEPLAPEILERGENILEIHIGRVCLTQQAVENIKDKDPFLFGTWDFYDFETQATGVLRGTSSEFDIKAEYLVKIDDFFLNYLYKNTFPFELHQATGAEYVTLAACQMSCKDIFEKSSSQEGSKFSKSNGLKYHCRAKLVGLRENSKDINFGVLEYWIRLKHPMDQVIRQYREKLKAEGYIMGNEMSVVEARRPIDSMNELIIRIIRCKGLKSRQKHLQPSPYIAYKFYDHSHHTSVTIPSSNSPEFHDLRRIPVQMNSDLHQYLKLQNLQIYVLDELDPDESVYLGVATIPLIQLCHNKNISGSFELHDNQHASNGTLEVELTWQHSYMYQDNSFTKPINSVALLPGEEGIKNENQPSRHTAPVKEETKDQPDAADYSKQIPNATPKEIRTPKKKERQKKPNQEVMDSGLMSPPAVQIVKGILKNRENIQPEKSLSESLKDKDVLEALIMPDLQIKDDSPIESTKSALEEDIKPTSSLERSREIKEKLEAAAKKLEKSTIDDTVLTKPNTEESKPISSNKVSQPNTYESEKKKKKQPKKTPSKSTLVNDPASGTNNILSENDDVIVDKKVKKKSPIKPELNPDEIVVEISSVEIADSADLLTDNNIKFIYVEYRLPGISLESTETISLQKPSVNQEIKKMNYNFKKTFDVSFNKNYMIRQHIATMLTEEPNKYIVFTLVQEPTADSEADCEDIGTAKVNVKTLLKESRNLENERIPIYSYKNKSVIIGYIIVTIQILGVLRAIEKELKT
Sbjct: 1 MNLQYQAPNTPNSARYKSQDLYSDSNTDLNAVIPKMDLAQERKTISQWTKDYLEDKYLRLQDDHETLKKHARLQELKIKKLGTKLLKITSDAKKNGDITPKTDDFEEFRRKCSILESQNGLLKDKVKLLQSQLLAQGKKASVYDNVPSRIKSGAIERSNSIQNSGRKNNIRVIKPRGELYPLSPRRDESVTGDQSLISLNKVVEDLKYEVHRLQIENEELLKKAYRREDEKLSPEHYKSNLKDNLDMIRVTRDIKEKEIQVNVLHGKYEDLKTKQQYLERNNREMSDEIERLTSRLRSTDDFAGNAEGQIRNVTVLRKRINDLEATNNDFKKEIYLLKESNDKLTNDAFNTERERDWREKEMNYRAKIAQLELTLKRDVSEKGGVLNKLESERDRVDNAEKEMSNLRLRNYELQAQIEELSDKLKFFSKEASLNPQEIEEALMIIQHKRNMVHAQSTPELDFIQKIDKNKDQDLTRKLLECEMNHAETIQELEKTRSLLRTQYKISNDYRQESEKISQRLDEIKKDYEERLTEYARLLDIRAARIHKLEAQLKDIAYGTRNTQIETILEPDLEPLAPEILERGENILEIHIGRVCLTQQAVENIKDKDPFLFGTWDFYDFETQATGVLRGTSSEFDIKAEYLVKIDDFFLNYLYKNTFPFELHQATGAEYVTLAACQMSCKDIFEKSSSQEGSKFSKSNGLKYHCRAKLVGLRENSKDINFGVLEYWIRLKHPMDQVIRQYREKLKAEGYIMGNEMSVVEARRPIDSMNELIIRIIRCKGLKSRQKHLQPSPYIAYKFYDHSHHTSVTIPSSNSPEFHDLRRIPVQMNSDLHQYLKLQNLQIYVLDELDPDESVYLGVATIPLIQLCHNKNISGSFELHDNQHASNGTLEVELTWQHSYMYQDNSFTKPINSVALLPGEEGIKNENQPSRHTAPVKEETKDQPDAADYSKQIPNATPKEIRTPKKKERQKKPNQEVMDSGLMSPPAVQIVKGILKNRENIQPEKSLSESLKDKDVLEALIMPDLQIKDDSPIESTKSALEEDIKPTSSLERSREIKEKLEAAAKKLEKSTIDDTVLTKPNTEESKPISSNKVSQPNTYESEKKKKKQPKKTPSKSTLVNDPASGTNNILSENDDVIVDKKVKKKSPIKPELNPDEIVVEISSVEIADSADLLTDNNIKFIYVEYRLPGISLESTETISLQKPSVNQEIKKMNYNFKKTFDVSFNKNYMIRQHIATMLTEEPNKYIVFTLVQEPTADSEADCEDIGTAKVNVKTLLKESRNLENERIPIYSYKNKSVIIGYIIVTIQILGVLRAIEKELKT 1320
BLAST of NPHP8 vs. TrEMBL
Match: A0A210PNG1 (Protein fantom OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT14288 PE=4 SV=1) HSP 1 Score: 619.002 bits (1595), Expect = 0.000e+0 Identity = 384/1049 (36.61%), Postives = 624/1049 (59.49%), Query Frame = 3
Query: 168 AQERKTISQWTKDYLEDKYLRLQDDHETLKKHARLQEXXXXXXXXXXXXXXSDAKKNGDI---TPKT---------DDFEEFRRKCSILESQNGLLKDKVKLLQSQLLAQGKKASVYDNVPSRIKSGAIERSNSIQNSGRKNNIRVI----KPRGELY--PLSPRRDESVT---------GDQSLISLNKVVEDLKYEVHRLQIENEELLKKAYRRED-----EKLSPEHYKSNLKDNLDMIRVTRDIKEKEIQVNVLHGKYEDLKTKQQYLERNNREMSDEIERLTSRLRSTDDFAGNAEGQIRNVTVLRKRINDLEATNNDFKKEIYLLKESNDKLTNDAFNTERERDWREKEMNYRAKIAQLELTLKRDVSEKGGVLNKLESERDRVDNAEKEMSNLRLRNYELQAQIEELSDKLKFFSKEASLNPQEIEEALMIIQHKRNMVHAQSTPELDFIQKIDKNKDQDLTRKLLECEMNHAETIQELEKTRSLLRTQYKISNDYRQESEKISQRLDEIKKDYEERLTEYARLLDIRAARIHKLEAQLKDIAYGTRNTQIETILEPDLEPLAPEI-----LERGENILEIHIGRVCLTQQAVENIKDKDPFLFGTWDFYDFETQATGVLRGTSSEFDIKAEYLVKIDDFFLNYLYKNTFPFELHQATGAEYVTLAACQMSCKDIXXXXXXXXXXXXXXXNGLKYHCRAKLVGL-RENSKDINFGVLEYWIRLKHPMDQVIRQYREKLKAEGYIMGNEMSVVEA---------RRPIDSMNELIIRIIRCKGLKSRQKHLQPSPYIAYKFYDHSHHTSVTIPSSNSPEFHDLRRIPVQMNSDLHQYLKLQNLQIYVLDELDPDESVYLGVATIPLIQLCHNKNISGSFELHDNQHASNGTLEVELTWQHSYMY------QDNSFTKPINSVALLPGEEGIKNENQPSRHT--APVKEETKDQPDAADYSKQIPNATPKEIRTPKKKERQKKPNQEVMDSGLMSPPAVQ------IVKGILKNRENIQPEKSLSESLKDKDVLEALI-MPDLQ 3128
AQ+R+ +S+W +D LEDKYLR+ +++ LKKHAR QE KIK++ TKLL++ +D KK ++ P+ + EE K L+ QN LK+K+ +L Q LA K+ + Y++V SRI +G I R+ +S N+RV P+G + P PR S+ D + L + +E + EV ++ + LK+A ED ++++ E + +++N+D+IR+ R++KEK + L KY L+ Q ++ ++ M E+ERL ++ + + +++ T ++ +L +KE +LKE+N+K N AF+ +RER+WR++E + +IAQLE TLK D+ EKGG+L++L SE+D+ + + +++ +Y+ + + ++L K+KFF+KE++++ EIEEAL++++ +R Q PE DF+QK+D KD+D++R L+ + ++AETI ELEKTR++L Q+KI+ DY+QE E + RL+E++K+YE +L EYARLLDIRAARI KLE QL+D+AYGT+ +I + D E + LERG+N+ EIH+ +VCL+ + V+ I D +P +F TW+F++FE Q+T VL+G+ EFD ++Y+VK+DDFFL++L K++ ELHQ+ G +Y T+AACQ+ K+IF K+ + H A L G+ I FG +EYWIRL+ PMDQ +R Y+E+ KA GY+ NE + EA +RP D++NEL ++I+RC +K R+ ++QPSPY Y+F+D + H +V + S+N+PE++D PV M +L YLK L+++V D+ DP+++ YLG+A +PLI L HNK+I G FEL NGT+E+EL WQ++Y+ QD + + P ++ ++ Q + PVK+ ++ AA + + P+AT + P + R+ +P +++ L + P+ + VKG++ +I P S+S+S+ + + I MPD Q
Sbjct: 25 AQQRRMVSRWDRDSLEDKYLRMYEENLILKKHARKQEDKIKRMATKLLRLVNDKKKTNEVDGGEPRGKKVKDVEMEEKVEELSEKIRSLDKQNLQLKEKL-MLSKQQLATNKRTTPYNHVGSRISTG-IARTQPQPDSRLAKNMRVTGPMDSPQGRMTGSPTQPRYGHSLLENARADLHHKDDHIAQLQEQMEMYEMEVENMR--QQLRLKEAEHEEDLVKIKQQITAEQ-RVTVQENIDLIRLQREVKEKSTKFFTLQEKYVLLEQNMQTMKHSHDSMLMEMERLNMQVNEEQNRVLTLQNELKFGTTNNSKLIELNEQIMSLEKETQILKEANEKFVNSAFDLDREREWRQRENALKVQIAQLEATLKADLGEKGGILDQLASEKDQHERLQATFRQVQVEHYQQKEEYDDLKQKMKFFTKESAIDFTEIEEALVLVKQRRQ----QELPEPDFLQKVDNEKDKDVSRSLVILQADYAETIHELEKTRNMLVIQHKINKDYQQEVEIATNRLEEVRKEYEMKLDEYARLLDIRAARIKKLEVQLRDVAYGTKQFKIAPPV--DEEDAIADFDETIHLERGQNLFEIHVQKVCLSDEGVKQIGDDEPSVFCTWEFFEFEIQSTPVLKGSRPEFDFTSQYIVKVDDFFLHFLQKDSCTLELHQSFGQDYRTIAACQLVFKEIFNKTHG------------RIHGTATLTGVDSSGGAGIGFGSVEYWIRLRVPMDQALRLYKERTKALGYVTSNEKAATEALQALDETAAKRPADNVNELHVKILRCSDIKPRRDNVQPSPYCIYQFFDFNDHDTVILASTNNPEYNDHMTYPVPMTKELDHYLKTFQLKVFVFDDTDPEQTAYLGIADVPLIPLAHNKSIQGIFELKGANSKINGTVEMELRWQYTYIMSKGVRIQDPPVMEEVAPPYAPPHQDQSDSDRQSVAESDITPVKQRSR---VAAKFPE--PSATSTPMPAPPES-REGEPAKKIPKRRLHAEPSQEPSLVNDAVKGVIS---DIMP-SSMSDSMTETLPAQPSIHMPDNQ 1040 HSP 2 Score: 96.2857 bits (238), Expect = 4.461e-16 Identity = 61/169 (36.09%), Postives = 100/169 (59.17%), Query Frame = 3
Query: 3519 IVVEISSVEIADSADLLTDNNIKFIYVEYRLPGISLESTET-ISLQKPSVNQEIKKMNYNFKKTFDVSFNKNYMIRQHIATML-TEEPNK-YIVFTLVQEPT-ADSEADCEDIGTAKVNVKTLLKESRNLENERIPIYSYKNKSVXXXXXXXXXXXLGVLRAIEKELKT 4013
+ + IS + + + A++L +NI+ ++V Y GI + ET SL KP Q+I +NF KTF V KNY RQ +A+ML ++P + I FT+V EP D E DCED+G A V++KT+L + N+ + + + KN+ +IG + +++ L L+A+E E++
Sbjct: 1210 VTITISHLSLEEGANVLHRDNIRQLFVAYNFLGIEPQELETPFSLPKPKPGQQIA---FNFSKTFQVDIEKNYTRRQFLASMLLPDDPEQGRIRFTIVSEPPDEDMEGDCEDVGVAWVSIKTILMKRENIIEQDVEVLDVKNEKNVIGSLNLSVDCLAALQAVENEMQV 1375
BLAST of NPHP8 vs. TrEMBL
Match: D2ILT1 (RPGRIP1L-like protein (Fragment) OS=Schmidtea mediterranea OX=79327 PE=2 SV=1) HSP 1 Score: 617.076 bits (1590), Expect = 0.000e+0 Identity = 308/308 (100.00%), Postives = 308/308 (100.00%), Query Frame = 3
Query: 1587 ESEKISQRLDEIKKDYEERLTEYARLLDIRAARIHKLEAQLKDIAYGTRNTQIETILEPDLEPLAPEILERGENILEIHIGRVCLTQQAVENIKDKDPFLFGTWDFYDFETQATGVLRGTSSEFDIKAEYLVKIDDFFLNYLYKNTFPFELHQATGAEYVTLAACQMSCKDIXXXXXXXXXXXXXXXNGLKYHCRAKLVGLRENSKDINFGVLEYWIRLKHPMDQVIRQYREKLKAEGYIMGNEMSVVEARRPIDSMNELIIRIIRCKGLKSRQKHLQPSPYIAYKFYDHSHHTSVTIPSSNSPEFHD 2510
ESEKISQRLDEIKKDYEERLTEYARLLDIRAARIHKLEAQLKDIAYGTRNTQIETILEPDLEPLAPEILERGENILEIHIGRVCLTQQAVENIKDKDPFLFGTWDFYDFETQATGVLRGTSSEFDIKAEYLVKIDDFFLNYLYKNTFPFELHQATGAEYVTLAACQMSCKDIFEKSSSQEGSKFSKSNGLKYHCRAKLVGLRENSKDINFGVLEYWIRLKHPMDQVIRQYREKLKAEGYIMGNEMSVVEARRPIDSMNELIIRIIRCKGLKSRQKHLQPSPYIAYKFYDHSHHTSVTIPSSNSPEFHD
Sbjct: 1 ESEKISQRLDEIKKDYEERLTEYARLLDIRAARIHKLEAQLKDIAYGTRNTQIETILEPDLEPLAPEILERGENILEIHIGRVCLTQQAVENIKDKDPFLFGTWDFYDFETQATGVLRGTSSEFDIKAEYLVKIDDFFLNYLYKNTFPFELHQATGAEYVTLAACQMSCKDIFEKSSSQEGSKFSKSNGLKYHCRAKLVGLRENSKDINFGVLEYWIRLKHPMDQVIRQYREKLKAEGYIMGNEMSVVEARRPIDSMNELIIRIIRCKGLKSRQKHLQPSPYIAYKFYDHSHHTSVTIPSSNSPEFHD 308
BLAST of NPHP8 vs. TrEMBL
Match: A0A2T7NIC5 (C2 domain-containing protein OS=Pomacea canaliculata OX=400727 GN=C0Q70_19065 PE=4 SV=1) HSP 1 Score: 585.874 bits (1509), Expect = 0.000e+0 Identity = 352/908 (38.77%), Postives = 566/908 (62.33%), Query Frame = 3
Query: 168 AQERKTISQWTKDYLEDKYLRLQDDHETLKKHARLQEXXXXXXXXXXXXXXSDAKKN-------GDITPKTDDFEEFRRKCSILESQNGLLKDKVKLLQSQLL--AQGKKASVYDNVPSRIKSGAIERSNSIQNSGR-KNNIRVIKPRGE----LYPLSPRRDESVTGDQSLISLNKVVEDL-----KYEVHRLQIEN---EELLKKAYRRED-----EKLSPEHYKSNLKDNLDMIRVTRDIKEKEIQVNVLHGKYEDLKTKQQYLERNNREMSDEIERLTSRLRSTDDFAGNAEGQIRNVTVLRKRINDLEATNNDFKKEIYLLKESNDKLTNDAFNTERERDWREKEMNYRAKIAQLELTLKRDVSEKGGVLNKLESERDRVDNAEKEMSNLRLRNYELQAQIEELSDKLKFFSKEASLNPQEIEEALMIIQHKRNMVHAQSTPELDFIQKIDKNKDQDLTRKLLECEMNHAETIQELEKTRSLLRTQYKISNDYRQESEKISQRLDEIKKDYEERLTEYARLLDIRAARIHKLEAQLKDIAYGTRNTQI---------ETILEPDLEPLAPEILERGENILEIHIGRVCLTQQAVENIKDKDPFLFGTWDFYDFETQATGVLRGTSSEFDIKAEYLVKIDDFFLNYLYKNTFPFELHQATGAEYVTLAACQMSCKDIXXXXXXXXXXXXXXXNGLKYHCRAKLVGLRENSKDINFGVLEYWIRLKHPMDQVIRQYREKLKAEGYIMGNEMSVVE---------ARRPIDSMNELIIRIIRCKGLKSRQKHLQPSPYIAYKFYDHSHHTSVTIPSSNSPEFHDLRRIPVQMNSDLHQYLKLQNLQIYVLDELDPDESVYLGVATIPLIQLCHNKNISGSFELHDNQHASN-GTLEVELTWQHSYM 2753
AQ+R+ +S+ +D LEDKYLRL +++ LKKHAR QE KIK++ TKLL++ +D KK+ G + E + K LE N LK+K+ L + Q L A K+ Y+ V SRI +G I + ++Q R N+RVI P + L R + V +++ + +++ + K ++ L+IEN + L++A ED ++++ E +S +++N+DMI++ R++KEK ++ L KY ++ + L +N+ + E+ERL+ +++ + + ++RN +KR +L+ D ++EI LKE+N+K + AF+ ERER+WR++E + +IAQLE TLK D+ EKG ++++ +ERD + + E L++ ++++ + +++ +KLKFF+KE++L+ E+E+AL++++ K+ ++ P+ DF+QK+D ++D R+LLE + +AET+ ELEKTR++L Q+ I+ DY++E E +++L++ KK+YE +L EYARLLDIRAARI KLEAQL+D+AYGTR ++ LE L+ LERG+N+ EIHI +V L++ AV +I D++P LF TWDF++FE+Q+T VLRG+ +D ++Y+VK+DDFFL+YL K + ELHQ+ G +Y T+AACQ+ KDIF+K + H A L G+ + + +G +EYW+RL+ PMDQ +R Y+E+ KA GY+ N++ E ARRP+D++NEL I++I C LKSR+ +QPSPY Y+F+D+S H +V + +SN+PEFHD + PV M +L QYL++ +LQIYV D+ DP E+ Y+G+ IPL+ L K I G+FEL GT+++E+ WQH Y+
Sbjct: 27 AQQRRMVSKLDRDELEDKYLRLSEENLLLKKHARKQEDKIKRMATKLLRLVNDKKKHDLEIGKAGREVAAEEQLMELKGKVQNLEKINSHLKEKLALTKQQALTLAAAKRTMPYNYVQSRISTG-IPKPPTVQIDPRITKNLRVIGPSQDAPKRFATLQASRADHVVMEEAHMEKRQLLNTIDQLHEKLSMYELEIENLKEQNRLREAEFEEDIIKIKQQITSEQRQS-VQENIDMIKLQREVKEKSTRLIGLQNKYTAMEEDTRALRQNHDHILMEMERLSMQVKEEQNRVLTLQNELRNAATGQKRTLELQEQVVDLQREIDTLKEANEKFVSSAFDLEREREWRQRENKLKVQIAQLEATLKSDLGEKGSIIDRYANERDAHEKLQLEFRELQITYFQMKEKCDDMEEKLKFFTKESALDLTELEDALVLVKQKKQ----RAAPDPDFLQKVDMEINKDHKRQLLELQAEYAETVLELEKTRNMLVVQHNINKDYQKELESSNKQLEDTKKEYELKLDEYARLLDIRAARIKKLEAQLRDVAYGTRQYRVPPPDDDVESSVDLEESLQ------LERGQNLFEIHIEKVSLSEDAVRHIGDEEPSLFCTWDFFEFESQSTPVLRGSRPVYDFTSQYIVKVDDFFLHYLQKGSCTLELHQSFGQDYRTVAACQLVFKDIFDKPQG------------RIHGMAVLTGVADGETGVGYGTIEYWVRLRVPMDQALRLYKERTKALGYLSANKVQAEEVLQALDEKAARRPLDNINELHIKVISCAKLKSRRDDVQPSPYCVYQFFDYSDHDTVCVRNSNNPEFHDHKTFPVPMTPELDQYLRVTHLQIYVFDDTDPVETSYIGIVEIPLMLLRTQKQIKGTFELKRQDGTMGIGTMDLEIYWQHEYI 910 HSP 2 Score: 83.9593 bits (206), Expect = 2.706e-12 Identity = 58/171 (33.92%), Postives = 95/171 (55.56%), Query Frame = 3
Query: 3513 DEIVVEISSVEIADSADLLTDNNIKFIYVEYRLPGISLESTET-ISLQKPSVNQEIKKMNYNFKKTFDVSFNKNYMIRQHIATMLT--EEPNKYIVFTLVQEPTADSE-ADCEDIGTAKVNVKTLLKESRNLENERIPIYSYKNKSVXXXXXXXXXXXLGVLRAIEKELKT 4013
D + V +S + + + + + + NIK ++V Y G+ + TET SL KP +I +NF +T V ++ RQH+A ML E I FT+V EP D + ADCED+G A V+V+ +LK +L++ I I+ N +IG + VT++ L L+A++ E++
Sbjct: 1188 DTVTVVVSHLSLEEDSPPMVNPNIKQLFVAYSFVGLPPQDTETPFSLPKPRPQSQIA---FNFSRTIAVDMKRHLERRQHLALMLLPDHEDQGRIRFTVVSEPPEDEQDADCEDVGVAYVSVRDILKNKADLKDADIDIFDVGNPKRVIGQMNVTVECLAALQAVDLEMQV 1355
BLAST of NPHP8 vs. TrEMBL
Match: A0A1S3IMU7 (protein fantom isoform X3 OS=Lingula unguis OX=7574 GN=LOC106165255 PE=4 SV=1) HSP 1 Score: 585.489 bits (1508), Expect = 0.000e+0 Identity = 355/933 (38.05%), Postives = 587/933 (62.92%), Query Frame = 3
Query: 168 AQERKTISQWTKDYLEDKYLRLQDDHETLKKHARLQEXXXXXXXXXXXXXXSD---------AKKNGDITPKTDDFEEFRRKCSILESQNGLLKDKVKLLQSQLLAQGKKASVYDNVPSRIKSGAIERSNSIQNSGRKNNIRVIKPR----GELYPLSPRRDESVTGD--------QSLI-----SLNKVVEDLKYEVHRLQIENEELLKKAYRREDEKLSPEHYKSNLKDNLDMIRVTRDIKEKEIQVNVLHGKYEDLKTKQQYLERNNREMSDEIERLTSRLRSTDDFAGNAEGQIRNVTVLRKRINDLEATNNDFKKEIYLLKESNDKLTNDAFNTERERDWREKEMNYRAKIAQLELTLKRDVSEKGGVLNKLESERDRVDNAEKEMSNLRLRNYELQAQIEELSDKLKFFSKEASLNPQEIEEALMIIQHKRNMVHAQSTPELDFIQKIDKNKDQDLTRKLLECEMNHAETIQELEKTRSLLRTQYKISNDYRQESEKISQRLDEIKKDYEERLTEYARLLDIRAARIHKLEAQLKDIAYGTRNTQIETILEPDLEPLAPEI-----LERGENILEIHIGRVCLTQQAVENIKDKDPFLFGTWDFYDFETQATGVLRGTSSEFDIKAEYLVKIDDFFLNYLYKNTFPFELHQATGAEYVTLAACQMSCKDIXXXXXXXXXXXXXXXNGLKYHCRAKLVGLRENSKDINFGVLEYWIRLKHPMDQVIRQYREKLKAEGYIMGNEMSVVEARRPI---------DSMNELIIRIIRCKGLKSRQKHLQPSPYIAYKFYDHSHHTSVTIPSSNSPEFHDLRRIPVQMNSDLHQYLKLQNLQIYVLDELDPDESVYLGVATIPLIQLCHNKNISGSFELHDNQHASNGTLEVELTWQHSYMYQDNSFTKPINSVALLPGEEGIKNENQPSRH 2846
AQ+R+ +++W+K+ LEDKYLR+ +++ LKKHAR QE KIK++ TKLL++ SD AK+ DI + + EE K LE +NGLLK+K+ + + QL QGK+ + Y +V SRI +G I + + + R N+RV PR P PR S+ + + +I +N +D+++ +L+++ E + R + +++S E + L++N+D+IR+ R++K+K ++ L KY ++ + ++ ++ ++ E+E L +L+ ++ + + +++ + R++I +LE D KKE +LKE+N+KL + AF+ ERER+WR++E + +IAQL+ TLK DV EKGG+L++L ER+ + EKE+ +L L++ +L+ Q +EL +K+KFF+KE++++ EIEEAL++++ K+ ++ EL+F++++D+ K++DL ++++ + HAETI ELEKTR++L Q+KI+ DY+ E E ++++++E + +++ +L EYARLLDIRAARI KLE+QLKDIAYGTR +I E E E L+RGEN+ EIHI +V L+ + ++ + D+ P +F T+DFY+F+TQ+T V++G ++F+ +++VK+DDFFL+Y+ K++ ELHQA G Y T+AA Q+ +DIF+K + H +L G+ E + + +G L+YW+RLK PMDQ +R Y+E+ KA GYI N + A + + D++NEL +++++C G+K+R+ +QPSPY+ YKF+D H + + SSN+P F D + PV M +DL YLK Q+LQ+YV D+ DP+E+ YLG+A++PL+ L H+K I G FELH NGT++V+L WQ++Y+ S P +A P +K E P H
Sbjct: 36 AQQRRMVARWSKEELEDKYLRMYEENLLLKKHARKQEDKIKRMATKLLRLVSDKKKAQQEPGAKRVRDIETE-EMLEELHGKIRNLEKENGLLKEKLMVTKQQLSTQGKRNTPYSHVESRINTG-IPKPPTSERITR--NLRVAGPRESQRSVHSPGLPRYGHSLLEEARAENRHLEGVIEQQNEQINIYEQDIEFLREQLRVKEAEFEEDLLRIK-QQMSAEQ-RVTLQENVDLIRLQREVKDKATKLTSLQEKYTRMEENLRTVKSSHDQVLREMEALNQQLKQEENRVMSLQNELKLGSTSRRKIVELEEQIIDLKKESEILKEANEKLVSSAFDLEREREWRQREQALKVQIAQLDATLKADVGEKGGILDRLSHERETNERLEKELRDLNLQHLQLKEQHDELKEKMKFFTKESAIDFSEIEEALVLVKQKKE---KKAHLELEFLERVDEEKNKDLEKQVVLLQAEHAETIDELEKTRNMLIVQHKINKDYQMEVEAVTKKMEENRLEFDTKLDEYARLLDIRAARIKKLESQLKDIAYGTRQYRIPPREEGMEESEVEEFDESLHLQRGENLFEIHISKVTLSSEGLKQLGDEAPSIFCTYDFYEFDTQSTAVMKGAVADFEFTYQFVVKVDDFFLHYVQKDSTTVELHQAFGTNYQTVAAGQLKFRDIFDKPHG------------RVHGSIQLAGVGEGAVGLLYGTLDYWVRLKVPMDQALRLYKERTKALGYIESNVRATETALKTLDDSSVNRAEDNVNELHVKVLKCTGVKARRGEVQPSPYVVYKFFDFPDHDTSIVQSSNNPNFSDHKTFPVPMTADLDIYLKSQHLQVYVFDDTDPEEAAYLGMASVPLLPLSHDKAIKGIFELHAPDGTVNGTVDVQLKWQYTYLPPSISTKTPAQILATTP----MKPEKVPLLH 943 HSP 2 Score: 95.1301 bits (235), Expect = 1.198e-15 Identity = 62/171 (36.26%), Postives = 105/171 (61.40%), Query Frame = 3
Query: 3507 NPDEIVVEISSVEIADSADLLTDNNIKFIYVEYRLPGISLESTET-ISLQKPSVNQEIKKMNYNFKKTFDVSFNKNYMIRQHIATM-LTEEPNK-YIVFTLVQEPTADSE-ADCEDIGTAKVNVKTLLKESRNLENERIPIYSYKNKSVXXXXXXXXXXXLGVLRAIEKEL 4007
NPD +VV I+ + + + A L++ ++ ++VEYR G E ET +SL KP +Q+I +NFKK F V +Y RQ++A+M L ++P++ I FT+V EP D E +C D+GTA V++ +L++ ++ + IPIY +S +IG++ VT++ L A++ E+
Sbjct: 1229 NPDTVVVTIAHLSLEEGASALSNPAVQQLFVEYRFLGFPAEELETPVSLPKPKPDQQI---YFNFKKVFHVDAQDHYESRQYLASMLLPDDPDEGRIRFTVVSEPPEDDESGECNDVGTAFVSLTEILEKKEDVIDRDIPIYDIDEESTVIGHLNVTVECYAALHAVKLEM 1396
BLAST of NPHP8 vs. Ensembl Cavefish
Match: rpgrip1l (RPGRIP1 like [Source:NCBI gene;Acc:103034464]) HSP 1 Score: 496.123 bits (1276), Expect = 1.851e-152 Identity = 326/911 (35.78%), Postives = 524/911 (57.52%), Query Frame = 3
Query: 168 AQERKTISQWTKDYLEDKYLRLQDDHETLKKHARLQEXXXXXXXXXXXXXXSDAKK-----------NGDITPKTDDFEEFRRKCSILESQNGLLKDKVKLLQSQLLAQGKKASVYDNVPSRIKSGAIE-RSNSIQNSGRKNNIRVIKPR---GELYPLSPRRDESVTGDQSLISLNKVVEDLK--YEVHRLQIE----NEELLKKAYR---REDEKLSPEHYK--------SNLKDNLDMIRVTRDIKEKEIQVNVLHGKYEDLKTKQQYLERNNREMSDEIERLTSRLRSTDDFAGNAEGQIRNVTVLRKRINDLEATNNDFKKEIYLLKESNDKLTNDAFNTERERDWREKEMNYRAKIAQLELTLKRDVSEKGGVLNKLESERDRVDNAEKEMSNLRLRNYELQAQIEELSDKLKFFSKEASLNPQEIEEALMIIQHKRNMVHAQSTPELDFIQKIDKNKDQDLTRKLLECEMNHAETIQELEKTRSLLRTQYKISNDYRQESEKISQRLDEIKKDYEERLTEYARLLDIRAARIHKLEAQLKDIAYGTRNTQIETILEPDL--EPLAPEI-----LERGENILEIHIGRVCLTQQAVENIKDKDPFLFGTWDFYDFETQATGVLRGTSSEFDIKAEYLVKIDDFFLNYLYKNTFPFELHQATGAEYVTLAACQMSCKDIXXXXXXXXXXXXXXXNGLKYHCRAKLVGLRENSKDIN-FGVLEYWIRLKHPMDQVIRQYREKLKAEGYIMGNEMSVVEAR---------RPIDSMNELIIRIIRCKGLKSRQKHLQPSPYIAYKFYDHSHHTSVTIPSSNSPEFHDLRRIPVQMNSDLHQYLKLQNLQIYVLDELDPDESVYLGVATIPLIQLCHNKNISGSFELHDNQHASNGTLEVELTWQHSYM 2753
A+ R+ +++ +++ LED+YLRLQD++ LK+H QE KIK++ TKL+++ D K+ G + EE + K LE QN LK ++ + + QL Q + + Y +V SRI SG R ++ S R R + R GE+ P+ G L + +L+ E R QIE + E+L+ R RE E+ S H K S +K+N++MI++ + + EK VL G++ L+ Q+ ++ ++ +++ LT +L+ + E Q+ T+ +R +L D +KE LLKE+ DKL + AF+ +E+ W+ KE + +IAQLE+ LK D+++K +L+K+++ERD +N +E L+L+ E + ++EE+ +++KFF+KE+ ++ E+ EALM+I+ +R Q+ EL F+ KID+ D+ L E + HAET+QELEKTR++L Q+KI+ DY+ E E +++++D++K + E + + A+LLD+RAA+I KLEAQLKDIAYGT+ + PD+ + +A E L RGEN+LE+H+G + +A+E++ DKDP F T+ FYDFE Q+T V+ G+ ++ ++YLVK+DD FL+YL+ ++ E+ A G Y T+AA Q+ + E+ K +LVG+ S +I FG L+YW+RL+ P++Q IR Y+E+ KA GY+ + +A + DS+NEL + + C L+SR H QPSPY+ YK YD H + IPS+ P+F D PV MN+DL YL+ + L +YV D+LD + +YLG A +PLI L H+K I+G FEL D++ A++G ++V L W+ +Y+
Sbjct: 34 ARARQAVAKVSREELEDRYLRLQDENLLLKQHTHKQEDKIKRMATKLIRLVKDRKRVEQMTSAGRAVGGRDVEMEEMMEELQEKVQELEKQNEGLKQRLLIAKHQLQTQSHRPTPYSHVQSRINSGLRRLRQDTPPLSQRPLTPRGVGSRHVEGEISSKPPQGHLPRYGHSLLDEARSEIRNLENVIESQRAQIEEMERSAEMLRDQLRSKEREYEE-SLHHIKEQQASGQRSTIKENVEMIKLQKQLTEKGNAFIVLEGRFLQLQESQKTMKASHDAAMAKVDELTGQLKEERLKSVGLESQLHIKTLEERRTGELLMRIQDLEKERDLLKENCDKLISSAFDVSQEQKWKTKEQQLKLQIAQLEMALKSDLTDKNQILDKIKAERDLNENLMQENKELQLQFLEQKQKLEEIKNRMKFFTKESEIDAAELSEALMLIKVRRT----QANGELGFLGKIDEKIHVDVESSLKELQATHAETVQELEKTRNMLIIQHKINKDYQAEVEAVTRKMDDLKLENELKQEKLAQLLDMRAAKIKKLEAQLKDIAYGTKT----HVFRPDVTEDDVADEFDETVHLARGENLLEVHLGTALFSPEALESLGDKDPSTFCTYAFYDFELQSTAVVWGSQPTYNFTSQYLVKVDDLFLHYLHSSSVTVEVQLAEGLAYRTIAAGQLRPSQVLEREG-------------KVFGTLQLVGV---SGEIQAFGTLDYWLRLRVPIEQAIRLYKERAKALGYLSSSLRDQSQASTSSVPSTSFKKDDSLNELHVTVRCCSILRSRGPHSQPSPYVIYKLYDFPDHDTPIIPSTCEPQFEDHVTFPVAMNADLDAYLRAEALILYVFDDLDLENQLYLGKARVPLISLAHDKAITGMFELVDSEGAASGYIDVTLKWKLTYL 919
BLAST of NPHP8 vs. Ensembl Cavefish
Match: rpgrip1 (protein fantom-like [Source:NCBI gene;Acc:103030220]) HSP 1 Score: 208.764 bits (530), Expect = 4.053e-54 Identity = 224/933 (24.01%), Postives = 425/933 (45.55%), Query Frame = 3
Query: 171 QERKTISQWTKDYLEDKYLRLQDDHETLKKHARLQEXXXXXXXXXXXXXXSD--AKKNGDITPKTDDFEEFRRKCSILESQNGLLKDKVKLLQSQLLAQGKKASVYDNVPSRIKSGAIERSNSIQNSGRKNNIRVIKPRGELYPLSPRRDESV--TGDQSLISLNKVVEDLKYEVHRLQIENEELLKKAYRREDEKLSPEHYKSNLKDNLDMIRVTRDIKEKEIQVNVLHGKYEDLKTK--------QQYLERNNREMSDEIERLTSRLRSTDDFAGNAEGQIRNVTVLRKRINDLEATNNDFKKEIYLLKESNDKLTNDAFNTERERDWREKEMNYRAK---------IAQLELTLKRDVSEKGGVLNKLESERDR--------VDNAEKE---MSNLRLRNYELQAQI-------EELSDKLKFFSKEASLNPQEIEEALMIIQHKRNMVHAQSTPELDFIQKIDKNKDQDLTRKLLECEMNHAETIQELEKTRSLLRTQYKISNDYRQESEKISQRLDEIKKDYEERLTEYARLLDIRAARIHKLEAQLKDIAYGTRN-----------TQIET-ILEPDLEPLAPEILERGENILEIHIGRVCLTQQAVENIK---------DKDPFLFGTWDFYDFETQATGVLRGTSSEFDIKAEYLVKIDDFFLNYLYKNTFPFELHQATGA-EYVTLAACQMSCKDIXXXXXXXXXXXXXXXNGLKYHCRAKLVGLRENSKDINFGVLEYWIRLKHPMDQVIRQYREKL---KAEGYIMGNEMSVVEARRPIDSM--------NELIIRIIRCKGLKSRQKHLQPSPYIAYKFYDHSHHTSVTIPSSNSPEFHDLRRIPVQMNSDLHQYLKLQNLQIYVLDELDPDE-SVYLGVATIPLIQLCHNKNISGSFELHDNQHASNGTLEVELTWQHSY 2750
+ER+ + + +++LE++ LRLQ+++ LK+H R+QE K+++L TKLL++ G D +E + + LE Q L+ K+ + + Q+L+ + ++ R + R + + R E+ L SV T + + L + L+ + + E E+ +K+ R++ + ++ ++K+N+D+IR+ + + EK + VL K+ L+ Q+ L + + ++E L+ +L+ EGQ+ + + + +L+ D + E LLK+ D L + + ++ E + R + + +LE L+++ E+ + LE +DR ++ E+E + LR ++ ++ ++ L +KL ++E ++ +++ E LM I+ R + +Q L F+ + + K D +++L + +HAET+ EL KT+ LL Q+++ ND + E + +R + +++ + TE +LL RA +I+ L+ QLKD AY RN T +E +++P E + +L GE++LEIH+ T + +K ++ F T+ F DFE +T ++ G+ + + Y + D + ELHQA G +++T ++ + + + G + RA L G S+ GVLE+W+RL HP + ++++ AE + M + + NEL + + RC GL SR L P Y+ Y+ YD H++ T+ P F D P+ + +DL +YLK+ +L +YV D+ + YL +PL L + I G + L D A GT+ V L W++ +
Sbjct: 45 KERQRVFKVPREHLEEQCLRLQEENTLLKQHTRIQEQKLRRLSTKLLRLRYGHPGSAGGREADTEDTIQELETRVATLEGQKEALQGKLSVARQQILSLTGRPHHRPRTARGVEVDGGVRRAAQTAPARYAHSSLEDTREEIEKLHALLRSSVLETQNMRVTELELAAQSLRDTLKEKEREIEDTVKELRRQQVDG-----HRLSIKENVDVIRLQKQLSEKSTALLVLQEKFTSLQEAYEAKLEEDQKSLRESQGALLGKVEELSEQLKEEKQRVLMLEGQLSTAALSLQSLQELQEKVTDLEGERNLLKKGYDTLLESTLSAQSHQEEHEDKERERERRREEKRRAELQRLEEILEQERRER----DDLEIAKDRMRREHERTLEEREQEKALATELREKHVSMEQEVLQHKQEAASLQEKLSRVTQEFDMSVEDLSETLMQIKAFRLQLKSQEG--LRFL--VTEEKMMDSSQELSALQASHAETVVELHKTQHLLLMQHRLCNDLQAELKLELERAEMERQENRKWATEKDKLLKSRALQINSLQGQLKDFAYSPRNYNRAIPQQYTWTGVEQEVMQPMEENTSITLLREGESLLEIHLLGATFTPVGLRTMKQDRAGDTRGQQEVVTFCTYAFLDFEMHSTPLISGSQPNYGFTSSYTLSAHDLTKLGGQGASVHAELHQALGGVQFITRGRARIPLEGV------------LQRRGEQIKGRANLTG----SEGEILGVLEFWVRL-HPQIEPKEAHKDRATDRTAERWATHKPMDWSHIQPETQEIFDYGGGIPNELEVVLERCVGLSSRWPGLLPDSYLTYRLYDLPPHSTPTVLCCEDPVFSDSTTYPLAVTADLMEYLKVGSLWVYVFDDSEGRAPQTYLAKTPVPLQPLAAGRPIKGDYVLRDPAGAPRGTVRVHLQWRYPF 947 HSP 2 Score: 81.2629 bits (199), Expect = 7.497e-15 Identity = 51/140 (36.43%), Postives = 85/140 (60.71%), Query Frame = 3
Query: 3513 DEIVVEISSVEIADSADLLTDNNIKFIYVEYRLPGISLESTET-ISLQKPSVNQEIKKMNYNFKKTFDVSFNKNYMIRQHIATML-TEEPNK-YIVFTLVQEPTADSEADCEDIGTAKVNVKTLLKESRNLENERIPIYS 3923
D + VEI S+ S+ + D +++ +YVEYRL GI +E+TET +SL+KP+ +E+ +YNF + V + +R ++ TML +PN + FT+V EP D E +CED+G A ++++ LL ++ ++I I S
Sbjct: 1123 DRLRVEILSLLFDPSSSVALDQSVQQVYVEYRLLGIPMETTETPMSLRKPTKGEEV---HYNFSRVIHVDSMEAAPLRHYLYTMLEGTDPNSGRLKFTVVSEPLND-EDECEDVGQAYLDLQELLLTGNDVVEKQIDIIS 1258
BLAST of NPHP8 vs. Ensembl Medaka
Match: rpgrip1l (protein fantom [Source:NCBI gene;Acc:101169939]) HSP 1 Score: 327.791 bits (839), Expect = 1.309e-92 Identity = 270/914 (29.54%), Postives = 471/914 (51.53%), Query Frame = 3
Query: 162 DLAQERKT-----ISQWTKDYLEDKYLRLQDDHETLKKHARLQEXXXXXXXXXXXXXXSDAKK-----NGDITPKT--------DDFEEFRRKCSILESQNGLLKDKVKLLQSQLL-AQGKKASVYDNVPSRIKSG--AIERSNSIQNSGRKNNIRVI-----KPRGELYPLSPRRDESVTGDQ--SLISLNKVVEDLKYEVHRLQIENEELLKKAYRREDEKLSPEHY-----------KSNLKDNLDMIRVTRDIKEKEIQVNVLHGKYEDLKTKQQYLERNNREMSDEIERLTSRLRSTDDFAGNAEGQIRNVTVLRKRINDLEATNNDFKKEIYLLKESNDKLTNDAFNTERERDWREKEMNYRAKIAQLELTLKRDVSEKGGVLNKLESERDRVDNAEKEMSNLRLRNYELQAQIEELSDKLKFFSKEASLNPQEIEEALMIIQHKRNMVHAQSTPELDFIQKIDKNKDQDLTRKLLECEMNHAETIQELEKTRSLLRTQYKISNDYRQESEKISQRLDEIKKDYEERLTEYARLLDIRAARIHKLEAQLKDIAYGTRNTQIETILEPDLEPLAPEILER--GENILEIHIGRVCLTQQAVENIKDKDPFLFGTWDFYDFETQATGVLRGTSSEFDIKAEYLVKIDDFFLNYLYKNTFPFELHQATGAEYVTLAACQMSCKDIXXXXXXXXXXXXXXXNGLKYHCRAKLVGLRENSKDINFGVLEYWIRLKHPMDQVIRQYREKLKAEGYIMGNEM--SVVEARRPIDSMNELIIRIIRCKGLKSRQKHLQPSPYIAYKFYDHSHHTSVTIPSSNSPEFHDLRRIPVQMNSDLHQYLKLQNLQIYVLDELDPDESVYLGVATIPLIQLCHNKNISGSFELHDNQHASNGTLEVELTWQHSYMYQDNSFT 2774
DLA R +S+ ++D LED++ RL ++ LK+H Q+ KI+KLGTKL+++ D ++ G + P + + EE + L+++ LK ++ + ++Q++ +Q + + Y V ++ SG + S + R +R P G+L PR S+ + + +LN V+E + ++ L+ +E L ++ ++E E EH +S + N+ +I++ + + ++ V +L G++ L+ QQ L+ ++E LT++L+ + E ++N + + + L+ ++ ++E LL+E N +L + AF+ +++ W+ +E + +I+QLE LK D+ +K +L+K+++ERDR + +E + LR E + Q+EELS +LKF S+E + E+ EAL++I+ ++ +Q + +L F+ + + + ++ + + E HAET QELEKTR LL + +I DY+ E E + ++ ++ + +YE++L +LLD RAA+IHKLEA+ KDIAY + T EP + E R EN++E I V L+ ++ + D + F T+ FY FE AT V+ G S ++D + Y V +D FL+YL K++ ELHQA ++ T+ + ++ +D+ + H L G + + G LEY +RLK PM + R E + + ++ SV DS NEL I I RC L+S PSPY+ YKFY H S T+ PEF+DL+ V M+SDL +YL+ + L+IYV D + +++G A + L+ L +++ SG FEL D G +EV W+ +Y+ S T
Sbjct: 31 DLAGNRHAWAPQDVSRVSRDELEDRFFRLHEETLQLKQHIHKQDEKIRKLGTKLVRLVKDRERLQQMAAGKVQPPSRVRDIETEEMIEELQENVRGLQAEKEELKQRLLVAKNQVINSQRWRPTPYGRVQPQVDSGLAKLRDDASSPSRARPRGLRSWDTERKPPTGQL----PRYGHSLLEEARGEIRNLNNVIESQQSQIEELERASELLREELKKKEAE--YEEHLQQMRQQQTFSLRSQVNSNVSLIKLQKQLADRSNVVTMLEGRFVSLQEAQQTLKTCLDGAMAKVEELTAQLKEERLKSLELETVVQNANITKTQREKLQERIHELEQERDLLREENKRLQHSAFDISQQQKWQLQEQQLKLQISQLETALKADLVDKNEILDKMKAERDRNEQLAEENRRVHLRILEQKQQLEELSSRLKFCSRENDYSEAELTEALLLIKTRK----SQRSGDLGFLAEEEGSNSKETS--IRELRAAHAETFQELEKTRKLLSMESRICKDYKAELEVVVEKANKDRAEYEQKLKHQTQLLDARAAKIHKLEAKFKDIAYSPKT--FMTRAEPADTGESDEASGRTSCENLVEFQIVSVSLSPATLQALGDAELSTFCTYSFYLFELHATPVVTGVSPKYDFTSRYAVSMDKHFLDYLDKSSVTVELHQAQ--DWKTIGSGEIRLQDLLGREG-------------SVHGSIPLFGTQGSP---CLGSLEYCLRLKTPMAETKRLLAETAASSAHSAHPQLLPSVT------DSWNELFITIHRCSDLRSVHSQF-PSPYVVYKFYSFPDHPSATVHDCCDPEFNDLKSYFVPMDSDLDRYLRSETLRIYVFDFKEERMDMFVGKAAVSLLPLVNDQTFSGVFELVDPSGRPAGHIEVLFGWKLTYVPPPGSVT 905
BLAST of NPHP8 vs. Ensembl Medaka
Match: rpgrip1l (protein fantom [Source:NCBI gene;Acc:101169939]) HSP 1 Score: 292.738 bits (748), Expect = 6.745e-81 Identity = 260/914 (28.45%), Postives = 456/914 (49.89%), Query Frame = 3
Query: 162 DLAQERKT-----ISQWTKDYLEDKYLRLQDDHETLKKHARLQEXXXXXXXXXXXXXXSDAKK-----NGDITPKT--------DDFEEFRRKCSILESQNGLLKDKVKLLQSQLL-AQGKKASVYDNVPSRIKSG--AIERSNSIQNSGRKNNIRVI-----KPRGELYPLSPRRDESVTGDQ--SLISLNKVVEDLKYEVHRLQIENEELLKKAYRREDEKLSPEHY-----------KSNLKDNLDMIRVTRDIKEKEIQVNVLHGKYEDLKTKQQYLERNNREMSDEIERLTSRLRSTDDFAGNAEGQIRNVTVLRKRINDLEATNNDFKKEIYLLKESNDKLTNDAFNTERERDWREKEMNYRAKIAQLELTLKRDVSEKGGVLNKLESERDRVDNAEKEMSNLRLRNYELQAQIEELSDKLKFFSKEASLNPQEIEEALMIIQHKRNMVHAQSTPELDFIQKIDKNKDQDLTRKLLECEMNHAETIQELEKTRSLLRTQYKISNDYRQESEKISQRLDEIKKDYEERLTEYARLLDIRAARIHKLEAQLKDIAYGTRNTQIETILEPDLEPLAPEILER--GENILEIHIGRVCLTQQAVENIKDKDPFLFGTWDFYDFETQATGVLRGTSSEFDIKAEYLVKIDDFFLNYLYKNTFPFELHQATGAEYVTLAACQMSCKDIXXXXXXXXXXXXXXXNGLKYHCRAKLVGLRENSKDINFGVLEYWIRLKHPMDQVIRQYREKLKAEGYIMGNEM--SVVEARRPIDSMNELIIRIIRCKGLKSRQKHLQPSPYIAYKFYDHSHHTSVTIPSSNSPEFHDLRRIPVQMNSDLHQYLKLQNLQIYVLDELDPDESVYLGVATIPLIQLCHNKNISGSFELHDNQHASNGTLEVELTWQHSYMYQDNSFT 2774
DLA R +S+ ++D LED++ RL ++ LK+H Q+ KI+KLGTKL+++ D ++ G + P + + EE + L+++ LK ++ + ++Q++ +Q + + Y V ++ SG + S + R +R P G+L PR S+ + + +LN V+E + ++ L+ +E L ++ ++E E EH +S + N+ +I++ + + ++ V +L G++ L+ QQ L+ ++E LT++L+ + E ++N + + + L+ ++ ++E LL+E N +L + AF+ +++ W+ +E + +I+QLE LK D+ +K +L+K+++ERDR + +E + LR E + Q+EELS +LKF S+E + E+ EAL++I+ ++ +Q + +L F+ + + + ++ + + E HAET QELEKTR LL + +I DY+ E E + ++ ++ + +YE++L +LLD RAA+IHKLEA+ KDIAY + T EP + E R EN++E I V L+ ++ + D + F T Y V +D FL+YL K++ ELHQA ++ T+ + ++ +D+ + H L G + + G LEY +RLK PM + R E + + ++ SV DS NEL I I RC L+S PSPY+ YKFY H S T+ PEF+DL+ V M+SDL +YL+ + L+IYV D + +++G A + L+ L +++ SG FEL D G +EV W+ +Y+ S T
Sbjct: 57 DLAGNRHAWAPQDVSRVSRDELEDRFFRLHEETLQLKQHIHKQDEKIRKLGTKLVRLVKDRERLQQMAAGKVQPPSRVRDIETEEMIEELQENVRGLQAEKEELKQRLLVAKNQVINSQRWRPTPYGRVQPQVDSGLAKLRDDASSPSRARPRGLRSWDTERKPPTGQL----PRYGHSLLEEARGEIRNLNNVIESQQSQIEELERASELLREELKKKEAE--YEEHLQQMRQQQTFSLRSQVNSNVSLIKLQKQLADRSNVVTMLEGRFVSLQEAQQTLKTCLDGAMAKVEELTAQLKEERLKSLELETVVQNANITKTQREKLQERIHELEQERDLLREENKRLQHSAFDISQQQKWQLQEQQLKLQISQLETALKADLVDKNEILDKMKAERDRNEQLAEENRRVHLRILEQKQQLEELSSRLKFCSRENDYSEAELTEALLLIKTRK----SQRSGDLGFLAEEEGSNSKETS--IRELRAAHAETFQELEKTRKLLSMESRICKDYKAELEVVVEKANKDRAEYEQKLKHQTQLLDARAAKIHKLEAKFKDIAYSPKT--FMTRAEPADTGESDEASGRTSCENLVEFQIVSVSLSPATLQALGDAELSTFCT--------------------------YAVSMDKHFLDYLDKSSVTVELHQAQ--DWKTIGSGEIRLQDLLGREG-------------SVHGSIPLFGTQGSP---CLGSLEYCLRLKTPMAETKRLLAETAASSAHSAHPQLLPSVT------DSWNELFITIHRCSDLRSVHSQF-PSPYVVYKFYSFPDHPSATVHDCCDPEFNDLKSYFVPMDSDLDRYLRSETLRIYVFDFKEERMDMFVGKAAVSLLPLVNDQTFSGVFELVDPSGRPAGHIEVLFGWKLTYVPPPGSVT 905
BLAST of NPHP8 vs. Planmine SMEST
Match: SMESG000076081.1 (SMESG000076081.1) HSP 1 Score: 2499.93 bits (6478), Expect = 0.000e+0 Identity = 1313/1320 (99.47%), Postives = 1316/1320 (99.70%), Query Frame = 3
Query: 54 MNLQYQAPNTPNSARYKSQDLYSDSNTDLNAVIPKMDLAQERKTISQWTKDYLEDKYLRLQDDHETLKKHARLQEXXXXXXXXXXXXXXSDAKKNGDITPKTDDFEEFRRKCSILESQNGLLKDKVKLLQSQLLAQGKKASVYDNVPSRIKSGAIERSNSIQNSGRKNNIRVIKPRGELYPLSPRRDESVTGDQSLISLNKVVEDLKYEVHRLQIENEELLKKAYRREDEKLSPEHYKSNLKDNLDMIRVTRDIKEKEIQVNVLHGKYEDLKTKQQYLERNNREMSDEIERLTSRLRSTDDFAGNAEGQIRNVTVLRKRINDLEATNNDFKKEIYLLKESNDKLTNDAFNTERERDWREKEMNYRAKIAQLELTLKRDVSEKGGVLNKLESERDRVDNAEKEMSNLRLRNYELQAQIEELSDKLKFFSKEASLNPQEIEEALMIIQHKRNMVHAQSTPELDFIQKIDKNKDQDLTRKLLECEMNHAETIQELEKTRSLLRTQYKISNDYRQESEKISQRLDEIKKDYEERLTEYARLLDIRAARIHKLEAQLKDIAYGTRNTQIETILEPDLEPLAPEILERGENILEIHIGRVCLTQQAVENIKDKDPFLFGTWDFYDFETQATGVLRGTSSEFDIKAEYLVKIDDFFLNYLYKNTFPFELHQATGAEYVTLAACQMSCKDIXXXXXXXXXXXXXXXNGLKYHCRAKLVGLRENSKDINFGVLEYWIRLKHPMDQVIRQYREKLKAEGYIMGNEMSVVEARRPIDSMNELIIRIIRCKGLKSRQKHLQPSPYIAYKFYDHSHHTSVTIPSSNSPEFHDLRRIPVQMNSDLHQYLKLQNLQIYVLDELDPDESVYLGVATIPLIQLCHNKNISGSFELHDNQHASNGTLEVELTWQHSYMYQDNSFTKPINSVALLPGEEGIKNENQPSRHTAPVKEETKDQPDAADYSKQIPNATPKEIRTPKKKERQKKPNQEVMDSGLMSPPAVQIVKGILKNRENIQPEKSLSESLKDKDVLEALIMPDLQIKDDSPIESTKSALEEDIKPTSSLERSREIXXXXXXXXXXXXXSTIDDTVLTKPNTEESKPISSNKVSQPNTYESEXXXXXXXXXXXXXXXLVNDPASGTNNILSENXXXXXXXXXXXXSPIKPELNPDEIVVEISSVEIADSADLLTDNNIKFIYVEYRLPGISLESTETISLQKPSVNQEIKKMNYNFKKTFDVSFNKNYMIRQHIATMLTEEPNKYIVFTLVQEPTADSEADCEDIGTAKVNVKTLLKESRNLENERIPIYSYKNKSVXXXXXXXXXXXLGVLRAIEKELKT 4013
MNLQYQAPNTPNSARYKSQDLYSDSNTDLNA IPKMDLAQERKTISQWTKDYLEDKYLRLQDDHETLKKHARLQELKIKKLGTKLLKITSDAKKNGDITPKTDDFEEFRRKCSILESQNGLLKDKVKLLQSQLLAQGKKASVYDNVPSRIKSGAIERSNSIQNSGRKNNIRVIKPRGELYPLSPRRDESVTGDQSLISLNKVVEDLKYEVHRLQIENEELLKKAYRREDEKLSPEHYKSNLKDNLDMIRVTRDIKEKEIQVNVLHGKYEDLKTKQQYLERNNREMSDEIERLTSRLRSTDDFAGNAEGQIRNVTVLRKRINDLEATNNDFKKEIYLLKESNDKLTNDAFNTERERDWREKEMNYRAKIAQLELTLKRDVSEKGGVLNKLESERDRVDNAEKEMSNLRLRNYELQAQIEELSDKLKFFSKEASLNPQEIEEALMIIQHKRNMVHAQSTPELDFIQKIDKNKDQDLTRKLLECEMNHAETIQELEKTRSLLRTQYKISNDYRQESEKISQRLDEIKKDYEERLTEYARLLDIRAARIHKLEAQLKDIAYGTRNTQIETILEPDLEPLAPEILERGENILEIHIGRVCLTQQAVENIKDKDPFLFGTWDFYDFETQATGVLRGTSSEFDIKAEYLVKIDDFFLNYLYKNTFPFELHQATGAEYVTLAACQMSCKDIFEKSSSQEGSKFSKSNGLKYHCRAKLVGLRENSKDINFGVLEYWIRLKHPMDQVIRQYREKLKAEGYIMGNEMSVVEARRPIDSMNELIIRIIRCKGLKSRQKHLQPSPYIAYKFYDHSHHTSVTIPSSNSPEFHDLRRIPVQMNSDLHQYLKLQNLQIYVLDELDPDESVYLGVATIPLIQLCHNKNISGSFEL+DNQHA+NGTLEVELTWQHSYMYQDNSFTKPINSVALLPGEEGIKNENQPSRHTAPVKEETKDQPDAADYSKQIPNATPKEIRTPKKKERQKKPNQEVMDSGLMSPPAVQIVKGILKNRENIQPEKSLSESLKDKDVLEALIMPDLQIKDDSPIESTKSALEEDIKPTSSLERSREIKEKLEAAAKKLEKSTIDDTVLTKPNTEESKPISSNKVSQPNTYE EKKKKKQPKKTPSKSTLVNDP SGTNNILSENDDVIVDKKVKKKSPIKPELNPDEIVVEI+SVEIADSADLLTDNNIKFIYVEYRLPGISLESTETISLQKPS NQEIKKMNYNFKKTFDVSFNKNYMIRQHIATMLTEEPNKYIVFTLVQEPTADSEADCEDIGTAKVNVKTLLKESRNLENERIPIYSYKNKSVIIGYIIVTIQILGVLRAIEKELKT
Sbjct: 1 MNLQYQAPNTPNSARYKSQDLYSDSNTDLNAAIPKMDLAQERKTISQWTKDYLEDKYLRLQDDHETLKKHARLQELKIKKLGTKLLKITSDAKKNGDITPKTDDFEEFRRKCSILESQNGLLKDKVKLLQSQLLAQGKKASVYDNVPSRIKSGAIERSNSIQNSGRKNNIRVIKPRGELYPLSPRRDESVTGDQSLISLNKVVEDLKYEVHRLQIENEELLKKAYRREDEKLSPEHYKSNLKDNLDMIRVTRDIKEKEIQVNVLHGKYEDLKTKQQYLERNNREMSDEIERLTSRLRSTDDFAGNAEGQIRNVTVLRKRINDLEATNNDFKKEIYLLKESNDKLTNDAFNTERERDWREKEMNYRAKIAQLELTLKRDVSEKGGVLNKLESERDRVDNAEKEMSNLRLRNYELQAQIEELSDKLKFFSKEASLNPQEIEEALMIIQHKRNMVHAQSTPELDFIQKIDKNKDQDLTRKLLECEMNHAETIQELEKTRSLLRTQYKISNDYRQESEKISQRLDEIKKDYEERLTEYARLLDIRAARIHKLEAQLKDIAYGTRNTQIETILEPDLEPLAPEILERGENILEIHIGRVCLTQQAVENIKDKDPFLFGTWDFYDFETQATGVLRGTSSEFDIKAEYLVKIDDFFLNYLYKNTFPFELHQATGAEYVTLAACQMSCKDIFEKSSSQEGSKFSKSNGLKYHCRAKLVGLRENSKDINFGVLEYWIRLKHPMDQVIRQYREKLKAEGYIMGNEMSVVEARRPIDSMNELIIRIIRCKGLKSRQKHLQPSPYIAYKFYDHSHHTSVTIPSSNSPEFHDLRRIPVQMNSDLHQYLKLQNLQIYVLDELDPDESVYLGVATIPLIQLCHNKNISGSFELYDNQHAANGTLEVELTWQHSYMYQDNSFTKPINSVALLPGEEGIKNENQPSRHTAPVKEETKDQPDAADYSKQIPNATPKEIRTPKKKERQKKPNQEVMDSGLMSPPAVQIVKGILKNRENIQPEKSLSESLKDKDVLEALIMPDLQIKDDSPIESTKSALEEDIKPTSSLERSREIKEKLEAAAKKLEKSTIDDTVLTKPNTEESKPISSNKVSQPNTYEPEKKKKKQPKKTPSKSTLVNDPVSGTNNILSENDDVIVDKKVKKKSPIKPELNPDEIVVEITSVEIADSADLLTDNNIKFIYVEYRLPGISLESTETISLQKPSFNQEIKKMNYNFKKTFDVSFNKNYMIRQHIATMLTEEPNKYIVFTLVQEPTADSEADCEDIGTAKVNVKTLLKESRNLENERIPIYSYKNKSVIIGYIIVTIQILGVLRAIEKELKT 1320 The following BLAST results are available for this feature:
BLAST of NPHP8 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of NPHP8 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of NPHP8 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of NPHP8 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of NPHP8 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 4
BLAST of NPHP8 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of NPHP8 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of NPHP8 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of NPHP8 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 2
BLAST of NPHP8 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of NPHP8 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of NPHP8 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of NPHP8 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 2
BLAST of NPHP8 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 1
Analyses
This transcript is derived from or has results from the following analyses Cross References
External references for this transcript
Sequences
The following sequences are available for this feature:
transcript sequence >SMED30032498 ID=SMED30032498|Name=NPHP8|organism=Schmidtea mediterranea sexual|type=transcript|length=4152bpback to top protein sequence of SMED30032498-orf-1 >SMED30032498-orf-1 ID=SMED30032498-orf-1|Name=SMED30032498-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1321bp MNLQYQAPNTPNSARYKSQDLYSDSNTDLNAVIPKMDLAQERKTISQWTKback to top Aliases
The feature 'NPHP8' has the following synonyms
Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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