DUF89 domain-containing protein

Overview


Name	DUF89 domain-containing protein
Smed ID	SMED30032475
Length (bp)	1355

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of DUF89 domain-containing protein (SMED30032475) t-SNE clustered cells

Violin plots show distribution of expression levels for DUF89 domain-containing protein (SMED30032475) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of DUF89 domain-containing protein (SMED30032475) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for DUF89 domain-containing protein (SMED30032475) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30032475

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 10

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
intestinal phagocyte	SMED30032475	h1SMcG0012128	Contig5043	GPL15192	PMID:23079596 Forsthoefel et al., 2012
intestinal phagocyte	SMED30032475	h1SMcG0012129	Contig5043	GPL15192	PMID:23079596 Forsthoefel et al., 2012
pigment cell	SMED30032475	h1SMcG0012129	SmedASXL_008434	SmedAsxl_ww_GCZZ01	PMID:29158443 He et al., 2017
gut	SMED30032475	h1SMcG0012129	dd_Smed_v4_2075_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30032475	h1SMcG0012129	dd_Smed_v4_2075_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30032475	h1SMcG0012129	dd_Smed_v4_2075_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30032475	h1SMcG0012129	Contig39552	newmark_ests	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30032475	h1SMcG0012129	Contig39552	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30032475	h1SMcG0012129	Contig52133	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30032475	h1SMcG0012129	Contig52133	newmark_ests	PMID:29674431 Fincher et al., 2018

Note: Hover over icons to view figure legend

Homology

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BLAST of DUF89 domain-containing protein vs. Ensembl Human
Match: PANK3 (pantothenate kinase 3 [Source:HGNC Symbol;Acc:HGNC:19365])

HSP 1 Score: 68.5514 bits (166), Expect = 5.697e-12
Identity = 48/193 (24.87%), Postives = 81/193 (41.97%), Query Frame = 3

Query:  741 DEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQSEIFRKEYSYLKKVYTLDFVN------FYFVNNGHSGALGAMVSCP 1301
            D+ +P +   +GSG   + ++S   +         G  F+G+C  +    ++EE ++MA+KGD    D    DI   D     +PG       G +    K  S  +K D+A + +     N    A  C + EK+  V F GN  +        S     Y LD+ +       +  + G+ GA+GA++  P
Sbjct:  180 DDPYPLLVVNIGSGVSILAVHSKDNYKRVTGTSLGGGTFLGLCSLLTGCESFEEALEMASKGDSTQADKLVRDIYGGDYERFGLPGWAVASSFGNMIYKEKRES-VSKEDLARATLVTITNNIGSVARMCAVNEKINRVVFVGNFLRVNTL----SMKLLAYALDYWSKGQLKALFLEHEGYFGAVGALLGLP 367

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BLAST of DUF89 domain-containing protein vs. Ensembl Human
Match: PANK1 (pantothenate kinase 1 [Source:HGNC Symbol;Acc:HGNC:8598])

HSP 1 Score: 63.929 bits (154), Expect = 1.830e-10
Identity = 48/190 (25.26%), Postives = 79/190 (41.58%), Query Frame = 3

Query:  741 DEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQSEIFRKEYSYLKKVYTLDFVN------FYFVNNGHSGALGAMV 1292
            D  +P +   MGSG   + + S   +         G  F+G+C  +     +EE ++MAAKGD  NVD   +DI   D     + G       G +    K  S  +K D+A + +     N    A  C + E +  V F GN  +  +   +       Y +DF +       +  + G+ GA+GA++
Sbjct:  180 DNPYPMLLVNMGSGVSILAVYSKDNYKRVTGTSLGGGTFLGLCCLLTGCETFEEALEMAAKGDSTNVDKLVKDIYGGDYERFGLQGSAVASSFGNMMSKEKRDS-ISKEDLARATLVTITNNIGSIARMCALNENIDRVVFVGNFLRINMVSMKLL----AYAMDFWSKGQLKALFLEHEGYFGAVGALL 364

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BLAST of DUF89 domain-containing protein vs. Ensembl Human
Match: PANK1 (pantothenate kinase 1 [Source:HGNC Symbol;Acc:HGNC:8598])

HSP 1 Score: 60.4622 bits (145), Expect = 3.744e-9
Identity = 49/190 (25.79%), Postives = 79/190 (41.58%), Query Frame = 3

Query:  741 DEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQSEIFRKEYSYLKKVYTLDFVN------FYFVNNGHSGALGAMV 1292
            D  +P +   MGSG   + + S   +         G  F+G+C  +     +EE ++MAAKGD  NVD   +DI   D     + G       G +    K  S  +K D+A + +     N    A  C + E +  V F GN  +  +     S     Y +DF +       +  + G+ GA+GA++
Sbjct:  405 DNPYPMLLVNMGSGVSILAVYSKDNYKRVTGTSLGGGTFLGLCCLLTGCETFEEALEMAAKGDSTNVDKLVKDIYGGDYERFGLQGSAVASSFGNMMSKEKRDS-ISKEDLARATLVTITNNIGSIARMCALNENIDRVVFVGNFLRINMV----SMKLLAYAMDFWSKGQLKALFLEHEGYFGAVGALL 589

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BLAST of DUF89 domain-containing protein vs. Ensembl Human
Match: PANK2 (pantothenate kinase 2 [Source:HGNC Symbol;Acc:HGNC:15894])

HSP 1 Score: 56.6102 bits (135), Expect = 2.913e-8
Identity = 43/183 (23.50%), Postives = 76/183 (41.53%), Query Frame = 3

Query:  750 FPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQ-SEIFRKEYSYLKKVYTLDFVNFYFV-NNGHSGALGAMV 1292
            +P +   +GSG   + + S   +         G  F G+C  +     +EE ++MA++GD   VD    DI   D     +PG       G +    K     +K D+A + +     N    A  C + E +  V F GN  + + I  +  +Y    ++   +   F  + G+ GA+GA++
Sbjct:   92 YPLLLVNIGSGVSILAVYSKDNYKRVTGTSLGGGTFFGLCCLLTGCTTFEEALEMASRGDSTKVDKLVRDIYGGDYERFGLPGWAVASSFGNMMSKEKR-EAVSKEDLARATLITITNNIGSIARMCALNENINQVVFVGNFLRINTIAMRLLAYALDYWSKGQLKALFSEHEGYFGAVGALL 273

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Query:  750 FPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQ-SEIFRKEYSYLKKVYTLDFVNFYFV-NNGHSGALGAMV 1292
            +P +   +GSG   + + S   +         G  F G+C  +     +EE ++MA++GD   VD    DI   D     +PG       G +    K     +K D+A + +     N    A  C + E +  V F GN  + + I  +  +Y    ++   +   F  + G+ GA+GA++
Sbjct:   92 YPLLLVNIGSGVSILAVYSKDNYKRVTGTSLGGGTFFGLCCLLTGCTTFEEALEMASRGDSTKVDKLVRDIYGGDYERFGLPGWAVASSFGNMMSKEKR-EAVSKEDLARATLITITNNIGSIARMCALNENINQVVFVGNFLRINTIAMRLLAYALDYWSKGQLKALFSEHEGYFGAVGALL 273

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BLAST of DUF89 domain-containing protein vs. Ensembl Celegans
Match: pnk-1 (PaNtothenate Kinase [Source:UniProtKB/TrEMBL;Acc:H2KYP7])

HSP 1 Score: 65.0846 bits (157), Expect = 2.938e-11
Identity = 83/349 (23.78%), Postives = 140/349 (40.11%), Query Frame = 3

Query:  297 SLDRGCSLTKVIYFDKSDKNLADEDPSIDT----------VILTLALFDNNNLDEVLLILKENAYFPENQTLPFHVTGAGGDKYSKRIKEILERDVIFIDEYLSQARGTYFFLKYASLEDIIYENVEIEDVEPIEAPFASNIKGHFDTIVTNNITEEDDEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNK-----DISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLF-QSEIFRKEYSYLKKVYTLDFVNFYFVNNGHSGALGAMVS 1295
            S+D G +L KV+Y    D+ L +E  +  T          V++    F   ++D  +  LKE  +    +    H TG G  KYS+ I + L   +   DE  S   G  F L     E   Y +  I   +    P A+++                   +P +   +G+G   ++++S  ++         G  F+G+   +    N++E+++MA +GD RNVD    DI      Y ++     LI  G +A  N+        +    DIA SL+ +   N    A        +K ++FGG    Q  I  +  S+    ++   +   ++   H G LGAM S
Sbjct:   71 SVDIGGTLIKVVYSSVMDEELPEESLNGHTRKYAYEDGKRVLVNFKKF--TDMDRFINFLKE-VWTDRKRGDVIHCTGGGSYKYSEIIMKELGVRLQRTDEMRSLIFGVNFLLSTNVDESFTYHHDAIGRNKFQYRPIAADLI------------------YPFLLVNIGTGISILKVDSPTSYERVGGSSMGGGTFMGLGSLLTPAQNFDELLEMANRGDHRNVDKLVCDIYGG--AYDELGLKADLIA-GSMAKCNRFEETTKKQQHKPEDIAKSLLLMVSNNIGQMAYLYGTRYNLKRIYFGGYFIRQDPITMRTLSFAINYWSKGEIEALYLK--HEGYLGAMGS 393

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Query:  297 SLDRGCSLTKVIYFDKSDKNLADEDPSIDT----------VILTLALFDNNNLDEVLLILKENAYFPENQTLPFHVTGAGGDKYSKRIKEILERDVIFIDEYLSQARGTYFFLKYASLEDIIYENVEIEDVEPIEAPFASNIKGHFDTIVTNNITEEDDEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNK-----DISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLF-QSEIFRKEYSYLKKVYTLDFVNFYFVNNGHSGALGAMVS 1295
            S+D G +L KV+Y    D+ L +E  +  T          V++    F   ++D  +  LKE  +    +    H TG G  KYS+ I + L   +   DE  S   G  F L     E   Y +  I   +    P A+++                   +P +   +G+G   ++++S  ++         G  F+G+   +    N++E+++MA +GD RNVD    DI      Y ++     LI  G +A  N+        +    DIA SL+ +   N    A        +K ++FGG    Q  I  +  S+    ++   +   ++   H G LGAM S
Sbjct:   71 SVDIGGTLIKVVYSSVMDEELPEESLNGHTRKYAYEDGKRVLVNFKKF--TDMDRFINFLKE-VWTDRKRGDVIHCTGGGSYKYSEIIMKELGVRLQRTDEMRSLIFGVNFLLSTNVDESFTYHHDAIGRNKFQYRPIAADLI------------------YPFLLVNIGTGISILKVDSPTSYERVGGSSMGGGTFMGLGSLLTPAQNFDELLEMANRGDHRNVDKLVCDIYGG--AYDELGLKADLIA-GSMAKCNRFEETTKKQQHKPEDIAKSLLLMVSNNIGQMAYLYGTRYNLKRIYFGGYFIRQDPITMRTLSFAINYWSKGEIEALYLK--HEGYLGAMGS 393

[Close]

BLAST of DUF89 domain-containing protein vs. Ensembl Celegans
Match: pnk-1 (PaNtothenate Kinase [Source:UniProtKB/TrEMBL;Acc:H2KYP7])

HSP 1 Score: 63.929 bits (154), Expect = 7.778e-11
Identity = 85/352 (24.15%), Postives = 137/352 (38.92%), Query Frame = 3

Query:  297 SLDRGCSLTKVIYFDKSDKNLADEDPSIDT----------VILTLALFDNNNLDEVLLILKENAYFPENQTLPFHVTGAGGDKYSKRIKEILERDVIFIDEYLSQARGTYFFLKYASLEDIIYENVEIEDVEPIEAPFASNIKGHFDTIVTNNITEED---DEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNK-----DISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLF-QSEIFRKEYSYLKKVYTLDFVNFYFVNNGHSGALGAMVS 1295
            S+D G +L KV+Y    D+ L +E  +  T          V++    F   ++D  +  LKE  +    +    H TG G  KYS+ I + L   +   DE  S   G  F L     E   Y                     H D I  N         D  +P +   +G+G   ++++S  ++         G  F+G+   +    N++E+++MA +GD RNVD    DI      Y ++     LI  G +A  N+        +    DIA SL+ +   N    A        +K ++FGG    Q  I  +  S+    ++   +   ++   H G LGAM S
Sbjct:  117 SVDIGGTLIKVVYSSVMDEELPEESLNGHTRKYAYEDGKRVLVNFKKF--TDMDRFINFLKE-VWTDRKRGDVIHCTGGGSYKYSEIIMKELGVRLQRTDEMRSLIFGVNFLLSTNVDESFTY---------------------HHDAIGRNKFQYRPIAADLIYPFLLVNIGTGISILKVDSPTSYERVGGSSMGGGTFMGLGSLLTPAQNFDELLEMANRGDHRNVDKLVCDIYGG--AYDELGLKADLIA-GSMAKCNRFEETTKKQQHKPEDIAKSLLLMVSNNIGQMAYLYGTRYNLKRIYFGGYFIRQDPITMRTLSFAINYWSKGEIEALYLK--HEGYLGAMGS 439

[Close]

BLAST of DUF89 domain-containing protein vs. Ensembl Celegans
Match: pnk-1 (PaNtothenate Kinase [Source:UniProtKB/TrEMBL;Acc:H2KYP7])

HSP 1 Score: 53.9138 bits (128), Expect = 1.075e-7
Identity = 58/235 (24.68%), Postives = 93/235 (39.57%), Query Frame = 3

Query:  297 SLDRGCSLTKVIYFDKSDKNLADEDPSIDT----------VILTLALFDNNNLDEVLLILKENAYFPENQTLPFHVTGAGGDKYSKRIKEILERDVIFIDEYLSQARGTYFFLKYASLEDIIYENVEIEDVEPIEAPFASNIKGHFDTIVTNNITEED---DEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDI 962
            S+D G +L KV+Y    D+ L +E  +  T          V++    F   ++D  +  LKE  +    +    H TG G  KYS+ I + L   +   DE  S   G  F L     E   Y                     H D I  N         D  +P +   +G+G   ++++S  ++         G  F+G+   +    N++E+++MA +GD RNVD    DI
Sbjct:  117 SVDIGGTLIKVVYSSVMDEELPEESLNGHTRKYAYEDGKRVLVNFKKF--TDMDRFINFLKE-VWTDRKRGDVIHCTGGGSYKYSEIIMKELGVRLQRTDEMRSLIFGVNFLLSTNVDESFTY---------------------HHDAIGRNKFQYRPIAADLIYPFLLVNIGTGISILKVDSPTSYERVGGSSMGGGTFMGLGSLLTPAQNFDELLEMANRGDHRNVDKLVCDI 327

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BLAST of DUF89 domain-containing protein vs. Ensembl Celegans
Match: pnk-4 (Pantothenate kinase [Source:UniProtKB/TrEMBL;Acc:Q18580])

HSP 1 Score: 53.9138 bits (128), Expect = 1.729e-7
Identity = 63/295 (21.36%), Postives = 117/295 (39.66%), Query Frame = 3

Query:  432 VLLILKENAYFPENQTLPFHVTGAGGDKYSKRIKEILERDVIFIDEYLSQARGTYFFLKYASLEDIIYENVEIEDVEPIEAPFASNIKGHFDTIVTNNITEEDDEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADS------PYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQSE-IFRKEYSYLKKVYTLDFVNFYFVNN-GHSGALGAMV 1292
            +L    EN    +  T+ F VT +   +  + I+++L+ ++  +D +     GT F L+    E   Y   E ++ E             F T+        +D  FP +   + +G   + +  +  F         G  F+G+   I   ++ EE+MD A +G     D    DI    +      P+  +      +  G+     ++  E +KN+   SL+ + +YN    A        VK VFF G L ++  I  K  S+    ++   +  YF+ +  ++  LGA +
Sbjct:   74 ILNFFGENCPLLKGTTVDFVVTASQNAEIEEVIRKVLDVELRHVDAFNGLVNGTSFLLRNIEAECFTYSFDESQEYE-------------FQTL-------NNDSMFPYLLINIRTGVSVVLVEGENQFKRLGGSSIGGGSFLGLTELITGVSDIEEMMDRALQGSPDEFDIFIRDIYGDRASNFNMDPH-LLAASFGRVTRGETVRRAENFDEQSKNNAILSLLRMILYNVSQLAYMLSEISNVKRVFFNGFLVRNRPIVMKTLSFACNYWSSGKLRAYFLRHENYTTGLGAFL 347

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BLAST of DUF89 domain-containing protein vs. Ensembl Fly
Match: fbl (gene:FBgn0011205 transcript:FBtr0307392)

HSP 1 Score: 65.0846 bits (157), Expect = 2.796e-11
Identity = 62/271 (22.88%), Postives = 113/271 (41.70%), Query Frame = 3

Query:  492 VTGAGGDKYSKRIKEILERDVIFIDEYLSQARGTYFFLKYASLEDIIYENV-EIEDVEPIEAPFASNIKGHFDTIVTNNITEEDDEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQ-SEIFRKEYSYLKKVYTLDFVNFYFV-NNGHSGALGAMVS 1295
             TG G  K+ +  ++ +   +   DE  +  +G  F   +   E   YEN  +I   E  +  F+                    + FP I   +GSG   + +     +         G  F+G+C  +    ++EE + +A KGD R VD   +DI   D     +PG +     G++   +K +S  ++ D+A++ +     N    A  C + EK+  V F GN  + + I  K  +Y  + ++   +   F+ + G+ GALG ++ 
Sbjct:   44 ATGGGAFKFEQDFRDQVNMKLAKFDELDTLIKGILFADLHNRTECYYYENARDILKSEKQQFNFS--------------------QPFPFILVNVGSGVSILAVYGPDNYKRISGTSLGGGTFLGLCCLLTGCTSFEEAIQLATKGDNRKVDKLVKDIYGGDYNRFGLPGDLVASSFGQMHLNDKRVS-VSREDLANATLVTITNNIGSIARMCALNEKIDRVVFVGNFLRVNPISMKLLAYAMEFWSNGTMKGLFLEHEGYFGALGCLLQ 293

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BLAST of DUF89 domain-containing protein vs. Ensembl Fly
Match: fbl (gene:FBgn0011205 transcript:FBtr0078190)

HSP 1 Score: 65.0846 bits (157), Expect = 4.047e-11
Identity = 47/186 (25.27%), Postives = 86/186 (46.24%), Query Frame = 3

Query:  744 EKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQ-SEIFRKEYSYLKKVYTLDFVNFYFV-NNGHSGALGAMVS 1295
            + FP I   +GSG   + +     +         G  F+G+C  +    ++EE + +A KGD R VD   +DI   D     +PG +     G++   +K +S  ++ D+A++ +     N    A  C + EK+  V F GN  + + I  K  +Y  + ++   +   F+ + G+ GALG ++ 
Sbjct:  168 QPFPFILVNVGSGVSILAVYGPDNYKRISGTSLGGGTFLGLCCLLTGCTSFEEAIQLATKGDNRKVDKLVKDIYGGDYNRFGLPGDLVASSFGQMHLNDKRVS-VSREDLANATLVTITNNIGSIARMCALNEKIDRVVFVGNFLRVNPISMKLLAYAMEFWSNGTMKGLFLEHEGYFGALGCLLQ 352

[Close]

BLAST of DUF89 domain-containing protein vs. Ensembl Fly
Match: fbl (gene:FBgn0011205 transcript:FBtr0078189)

HSP 1 Score: 65.0846 bits (157), Expect = 4.047e-11
Identity = 47/186 (25.27%), Postives = 86/186 (46.24%), Query Frame = 3

Query:  744 EKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQ-SEIFRKEYSYLKKVYTLDFVNFYFV-NNGHSGALGAMVS 1295
            + FP I   +GSG   + +     +         G  F+G+C  +    ++EE + +A KGD R VD   +DI   D     +PG +     G++   +K +S  ++ D+A++ +     N    A  C + EK+  V F GN  + + I  K  +Y  + ++   +   F+ + G+ GALG ++ 
Sbjct:  168 QPFPFILVNVGSGVSILAVYGPDNYKRISGTSLGGGTFLGLCCLLTGCTSFEEAIQLATKGDNRKVDKLVKDIYGGDYNRFGLPGDLVASSFGQMHLNDKRVS-VSREDLANATLVTITNNIGSIARMCALNEKIDRVVFVGNFLRVNPISMKLLAYAMEFWSNGTMKGLFLEHEGYFGALGCLLQ 352

[Close]

BLAST of DUF89 domain-containing protein vs. Ensembl Fly
Match: fbl (gene:FBgn0011205 transcript:FBtr0078186)

HSP 1 Score: 65.0846 bits (157), Expect = 4.053e-11
Identity = 47/186 (25.27%), Postives = 86/186 (46.24%), Query Frame = 3

Query:  744 EKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQ-SEIFRKEYSYLKKVYTLDFVNFYFV-NNGHSGALGAMVS 1295
            + FP I   +GSG   + +     +         G  F+G+C  +    ++EE + +A KGD R VD   +DI   D     +PG +     G++   +K +S  ++ D+A++ +     N    A  C + EK+  V F GN  + + I  K  +Y  + ++   +   F+ + G+ GALG ++ 
Sbjct:  184 QPFPFILVNVGSGVSILAVYGPDNYKRISGTSLGGGTFLGLCCLLTGCTSFEEAIQLATKGDNRKVDKLVKDIYGGDYNRFGLPGDLVASSFGQMHLNDKRVS-VSREDLANATLVTITNNIGSIARMCALNEKIDRVVFVGNFLRVNPISMKLLAYAMEFWSNGTMKGLFLEHEGYFGALGCLLQ 368

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BLAST of DUF89 domain-containing protein vs. Ensembl Fly
Match: fbl (gene:FBgn0011205 transcript:FBtr0307393)

HSP 1 Score: 65.0846 bits (157), Expect = 4.269e-11
Identity = 47/186 (25.27%), Postives = 86/186 (46.24%), Query Frame = 3

Query:  744 EKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQ-SEIFRKEYSYLKKVYTLDFVNFYFV-NNGHSGALGAMVS 1295
            + FP I   +GSG   + +     +         G  F+G+C  +    ++EE + +A KGD R VD   +DI   D     +PG +     G++   +K +S  ++ D+A++ +     N    A  C + EK+  V F GN  + + I  K  +Y  + ++   +   F+ + G+ GALG ++ 
Sbjct:  195 QPFPFILVNVGSGVSILAVYGPDNYKRISGTSLGGGTFLGLCCLLTGCTSFEEAIQLATKGDNRKVDKLVKDIYGGDYNRFGLPGDLVASSFGQMHLNDKRVS-VSREDLANATLVTITNNIGSIARMCALNEKIDRVVFVGNFLRVNPISMKLLAYAMEFWSNGTMKGLFLEHEGYFGALGCLLQ 379

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BLAST of DUF89 domain-containing protein vs. Ensembl Zebrafish
Match: pank4 (pantothenate kinase 4 (inactive) [Source:ZFIN;Acc:ZDB-GENE-040426-1592])

HSP 1 Score: 70.8626 bits (172), Expect = 9.398e-13
Identity = 90/364 (24.73%), Postives = 147/364 (40.38%), Query Frame = 3

Query:  297 SLDRGCSLTKVIY-------------FDKSDK---NLADEDPSID-------TVILTLALFDNNNLDEVLLILKENAYFPENQTLPFHVTGAGGDKYSKRIKEILERDVIFIDEYLSQARGTYFFLKYASLEDIIYENVEIEDVEPIEAPFASNIKGHFDTIVTNNITEEDDEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAE--KVKTVFFGGNLFQSE-IFRKEYSYLKKVYTLDFVNFYFVNN-GHSGALGAMVSCPED 1307
            ++D G SLTK+ Y             FD S K      D DP  +       T  L    F+N  ++  L  +K++    E + +    TG G  K+   I++ L+  V   DE     +G  F LK    E  +Y                     H D+      T  D   FP +   +GSG   +++ S+  F         G  F G+   + +T  ++E++ +A+KG   NVD   +DI         + G +     GK A T+K   EF+K D+A SL+ +   +  I  + C  A+   +  V+FGG   +   +     +Y    +T   V   F+ + G+ GA+GA +   E+
Sbjct:   36 AIDIGGSLTKLAYYSTVQHKVAKVRSFDHSAKVSFQETDGDPLYEISVQEEITARLHFIKFENAYIETCLDFIKDHLVNTETKVIK--ATGGGAYKFKDLIEKKLKLKVDKEDEMTCLIKGCNFVLKNIPHEAFVYAK-------------------HADSEFRFQNTHPD--IFPYLLINIGSGVSIVKVESEDKFERIGGSSIGGGTFWGLGALLTKTKRFDELLQLASKGQHTNVDMLVKDIYGGAYGSLGLTGDLIASSFGKSATTDK---EFSKEDMAKSLLHMISND--IGQLACLYAKLHNLTRVYFGGFFIRGHPVTMHTITYSINFFTKGEVQALFLRHEGYLGAIGAFLKGAEE 371

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Query:  297 SLDRGCSLTKVIY-------------FDKSDK---NLADEDPSID-------TVILTLALFDNNNLDEVLLILKENAYFPENQTLPFHVTGAGGDKYSKRIKEILERDVIFIDEYLSQARGTYFFLKYASLEDIIYENVEIEDVEPIEAPFASNIKGHFDTIVTNNITEEDDEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAE--KVKTVFFGGNLFQSE-IFRKEYSYLKKVYTLDFVNFYFVNN-GHSGALGAMVSCPED 1307
            ++D G SLTK+ Y             FD S K      D DP  +       T  L    F+N  ++  L  +K++    E + +    TG G  K+   I++ L+  V   DE     +G  F LK    E  +Y                     H D+      T  D   FP +   +GSG   +++ S+  F         G  F G+   + +T  ++E++ +A+KG   NVD   +DI         + G +     GK A T+K   EF+K D+A SL+ +   +  I  + C  A+   +  V+FGG   +   +     +Y    +T   V   F+ + G+ GA+GA +   E+
Sbjct:   36 AIDIGGSLTKLAYYSTVQHKVAKVRSFDHSAKVSFQETDGDPLYEISVQEEITARLHFIKFENAYIETCLDFIKDHLVNTETKVIK--ATGGGAYKFKDLIEKKLKLKVDKEDEMTCLIKGCNFVLKNIPHEAFVYAK-------------------HADSEFRFQNTHPD--IFPYLLINIGSGVSIVKVESEDKFERIGGSSIGGGTFWGLGALLTKTKRFDELLQLASKGQHTNVDMLVKDIYGGAYGSLGLTGDLIASSFGKSATTDK---EFSKEDMAKSLLHMISND--IGQLACLYAKLHNLTRVYFGGFFIRGHPVTMHTITYSINFFTKGEVQALFLRHEGYLGAIGAFLKGAEE 371

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BLAST of DUF89 domain-containing protein vs. Ensembl Zebrafish
Match: pank1a (pantothenate kinase 1a [Source:ZFIN;Acc:ZDB-GENE-040426-2846])

HSP 1 Score: 66.6254 bits (161), Expect = 1.410e-11
Identity = 49/186 (26.34%), Postives = 83/186 (44.62%), Query Frame = 3

Query:  741 DEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQ-SEIFRKEYSYLKKVYTLDFVNFYFV-NNGHSGALGAMV 1292
            D  FP +   +GSG   + +NS   +         G  F+G+C  +     +EE ++MA+KGD  NVD   +DI   D     + G       G +    K  S  +K D+A + +     N    A  C + EK++ V F GN  + + +  K  +Y    ++   +   F+ + G+ GA+GA +
Sbjct:  180 DNLFPMLLVNIGSGVSILAVNSKDNYKRVTGTSLGGGTFLGLCCLLTGCETFEEALEMASKGDSTNVDKLVKDIYGGDYQRFGLQGSAVASSFGHMMSKEKRDS-ISKEDLARATLVTITNNIGSIARMCAVNEKIERVVFVGNFLRINTVSTKLLAYAMDFWSKGQLRALFLEHEGYFGAVGAFL 364

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BLAST of DUF89 domain-containing protein vs. Ensembl Zebrafish
Match: pank1a (pantothenate kinase 1a [Source:ZFIN;Acc:ZDB-GENE-040426-2846])

HSP 1 Score: 66.2402 bits (160), Expect = 2.104e-11
Identity = 49/186 (26.34%), Postives = 83/186 (44.62%), Query Frame = 3

Query:  741 DEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQ-SEIFRKEYSYLKKVYTLDFVNFYFV-NNGHSGALGAMV 1292
            D  FP +   +GSG   + +NS   +         G  F+G+C  +     +EE ++MA+KGD  NVD   +DI   D     + G       G +    K  S  +K D+A + +     N    A  C + EK++ V F GN  + + +  K  +Y    ++   +   F+ + G+ GA+GA +
Sbjct:  181 DNLFPMLLVNIGSGVSILAVNSKDNYKRVTGTSLGGGTFLGLCCLLTGCETFEEALEMASKGDSTNVDKLVKDIYGGDYQRFGLQGSAVASSFGHMMSKEKRDS-ISKEDLARATLVTITNNIGSIARMCAVNEKIERVVFVGNFLRINTVSTKLLAYAMDFWSKGQLRALFLEHEGYFGAVGAFL 365

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Query:  741 DEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQ-SEIFRKEYSYLKKVYTLDFVNFYFV-NNGHSGALGAMV 1292
            D  FP +   +GSG   + +NS   +         G  F+G+C  +     +EE ++MA+KGD  NVD   +DI   D     + G       G +    K  S  +K D+A + +     N    A  C + EK++ V F GN  + + +  K  +Y    ++   +   F+ + G+ GA+GA +
Sbjct:  181 DNLFPMLLVNIGSGVSILAVNSKDNYKRVTGTSLGGGTFLGLCCLLTGCETFEEALEMASKGDSTNVDKLVKDIYGGDYQRFGLQGSAVASSFGHMMSKEKRDS-ISKEDLARATLVTITNNIGSIARMCAVNEKIERVVFVGNFLRINTVSTKLLAYAMDFWSKGQLRALFLEHEGYFGAVGAFL 365

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BLAST of DUF89 domain-containing protein vs. Ensembl Xenopus
Match: pank3 (pantothenate kinase 3 [Source:NCBI gene;Acc:100135204])

HSP 1 Score: 71.2478 bits (173), Expect = 6.937e-13
Identity = 48/193 (24.87%), Postives = 83/193 (43.01%), Query Frame = 3

Query:  741 DEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQSEIFRKEYSYLKKVYTLDFVN------FYFVNNGHSGALGAMVSCP 1301
            D+ +P +   +GSG   + +NS  ++   C     G  F+G+C  +    ++EE ++MA+ GD  N D    DI   D     +PG       G +   +K  S  +K D+A + +     N    A    + EK+  V F GN  +      +       Y LD+ +       +  + G+ GA+GA++  P
Sbjct:  180 DDPYPLLVVNIGSGVSILAVNSKDSYKRVCGTSLGGGTFLGLCSLLTGCESFEEALEMASAGDSTNADKLVRDIYGGDYERFGLPGWAVASSFGNMIYKDKRES-VSKEDLARATLVTITNNIGSIARMSAVNEKINKVIFVGNFLRVNTLSMKL----LAYALDYWSNGQLKALFLEHEGYFGAVGALLGMP 367

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BLAST of DUF89 domain-containing protein vs. Ensembl Xenopus
Match: ca1 (carbonic anhydrase I [Source:Xenbase;Acc:XB-GENE-957160])

HSP 1 Score: 62.3882 bits (150), Expect = 1.046e-9
Identity = 85/364 (23.35%), Postives = 150/364 (41.21%), Query Frame = 3

Query:  297 SLDRGCSLTKVIY-------------FDKSDKNLADEDPSID-------TVILTLALFDNNNLDEVLLILKENAYFPENQTLPFHVTGAGGDKYSKRIKEILERDVIFI---DEYLSQARGTYFFLKYASLEDIIYENVEIEDVEPIEAPFASNIKGHFDTIVTNNITEEDDEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEK--VKTVFFGGNLFQSE-IFRKEYSYLKKVYTLDFVNFYFVNN-GHSGALGAMVSCPED 1307
            ++D G SLTK+ Y             FD + K+ AD +   +       T  L    F+N  ++  L  +K++    E + +    TG G  K+    K+++E+ +      DE     +G  F LK    E  +Y    ++  +P         +  F T   N         FP +   +GSG   +++ ++  F         G  F G+   + +T  ++E++ +AAKG   NVD   +DI         + G +     GK A  +KD   F+K D+A SL+ +   +  I  + C  A++  +  V+FGG   +   +     SY    ++   V   F+ + G+ G +GA +   E 
Sbjct:   39 AIDIGGSLTKLAYYSTVQHKVAKVRSFDHTGKD-ADHEQLYEISVQEEITARLHFIKFENAYIEICLDFIKDHLVNTETKVIK--ATGGGAYKF----KDLIEKKLGLKYDEDEMTCLIKGCNFVLKNIPHEAFVY----VKHADP---------EFRFQTTHPN--------IFPYLLVNIGSGVSIVKVEAEDKFERIGGSSIGGGTFWGLGALLTKTKRFDELLQLAAKGHHTNVDMLVKDIYGGAYQILGLTGNLIASSFGKSATIDKD---FSKEDMAKSLLHMISND--IGQLACLYAKQHNLSQVYFGGFFIRGHPVTMHTISYSINFFSKGEVQALFLRHEGYLGTIGAFLKGAEQ 369

[Close]

BLAST of DUF89 domain-containing protein vs. Ensembl Xenopus
Match: ca1 (carbonic anhydrase I [Source:Xenbase;Acc:XB-GENE-957160])

HSP 1 Score: 62.003 bits (149), Expect = 1.125e-9
Identity = 85/364 (23.35%), Postives = 150/364 (41.21%), Query Frame = 3

Query:  297 SLDRGCSLTKVIY-------------FDKSDKNLADEDPSID-------TVILTLALFDNNNLDEVLLILKENAYFPENQTLPFHVTGAGGDKYSKRIKEILERDVIFI---DEYLSQARGTYFFLKYASLEDIIYENVEIEDVEPIEAPFASNIKGHFDTIVTNNITEEDDEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEK--VKTVFFGGNLFQSE-IFRKEYSYLKKVYTLDFVNFYFVNN-GHSGALGAMVSCPED 1307
            ++D G SLTK+ Y             FD + K+ AD +   +       T  L    F+N  ++  L  +K++    E + +    TG G  K+    K+++E+ +      DE     +G  F LK    E  +Y    ++  +P         +  F T   N         FP +   +GSG   +++ ++  F         G  F G+   + +T  ++E++ +AAKG   NVD   +DI         + G +     GK A  +KD   F+K D+A SL+ +   +  I  + C  A++  +  V+FGG   +   +     SY    ++   V   F+ + G+ G +GA +   E 
Sbjct:   36 AIDIGGSLTKLAYYSTVQHKVAKVRSFDHTGKD-ADHEQLYEISVQEEITARLHFIKFENAYIEICLDFIKDHLVNTETKVIK--ATGGGAYKF----KDLIEKKLGLKYDEDEMTCLIKGCNFVLKNIPHEAFVY----VKHADP---------EFRFQTTHPN--------IFPYLLVNIGSGVSIVKVEAEDKFERIGGSSIGGGTFWGLGALLTKTKRFDELLQLAAKGHHTNVDMLVKDIYGGAYQILGLTGNLIASSFGKSATIDKD---FSKEDMAKSLLHMISND--IGQLACLYAKQHNLSQVYFGGFFIRGHPVTMHTISYSINFFSKGEVQALFLRHEGYLGTIGAFLKGAEQ 366

[Close]

BLAST of DUF89 domain-containing protein vs. Ensembl Xenopus
Match: ca1 (carbonic anhydrase I [Source:Xenbase;Acc:XB-GENE-957160])

HSP 1 Score: 61.6178 bits (148), Expect = 1.788e-9
Identity = 48/190 (25.26%), Postives = 86/190 (45.26%), Query Frame = 3

Query:  750 FPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEK--VKTVFFGGNLFQSE-IFRKEYSYLKKVYTLDFVNFYFVNN-GHSGALGAMVSCPED 1307
            FP +   +GSG   +++ ++  F         G  F G+   + +T  ++E++ +AAKG   NVD   +DI         + G +     GK A  +KD   F+K D+A SL+ +   +  I  + C  A++  +  V+FGG   +   +     SY    ++   V   F+ + G+ G +GA +   E 
Sbjct:  189 FPYLLVNIGSGVSIVKVEAEDKFERIGGSSIGGGTFWGLGALLTKTKRFDELLQLAAKGHHTNVDMLVKDIYGGAYQILGLTGNLIASSFGKSATIDKD---FSKEDMAKSLLHMISND--IGQLACLYAKQHNLSQVYFGGFFIRGHPVTMHTISYSINFFSKGEVQALFLRHEGYLGTIGAFLKGAEQ 373

[Close]

BLAST of DUF89 domain-containing protein vs. Ensembl Xenopus
Match: cidea (cell death inducing DFFA like effector a [Source:Xenbase;Acc:XB-GENE-953574])

HSP 1 Score: 58.9214 bits (141), Expect = 5.706e-9
Identity = 39/147 (26.53%), Postives = 61/147 (41.50%), Query Frame = 3

Query:  741 DEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQ 1181
            D  +P +   +GSG   + + S   +         G  F+G+C  +     +EE ++MAAKGD  NVD   +DI   D     + G       G +    K  S  +K D+A + +     N    A  C + E +  V F GN  +
Sbjct:  176 DNPYPMLLVNIGSGVSILAVYSKDNYKRVTGTSLGGGTFLGLCCLLTGCETFEEALEMAAKGDSTNVDKLVKDIYGGDYERFSLQGSAVASSFGHMMSKEKRDS-ISKEDLARATLVTITNNIGSIARMCALNENIDRVIFVGNFLR 321

[Close]

BLAST of DUF89 domain-containing protein vs. Ensembl Mouse
Match: Pank4 (pantothenate kinase 4 [Source:MGI Symbol;Acc:MGI:2387466])

HSP 1 Score: 69.707 bits (169), Expect = 3.774e-12
Identity = 83/362 (22.93%), Postives = 149/362 (41.16%), Query Frame = 3

Query:  297 SLDRGCSLTKVIYFDKSDKNLA--------------DEDPSID-------TVILTLALFDNNNLDEVLLILKENAYFPENQTLPFHVTGAGGDKYSKRIKEILERDVIFIDEYLSQARGTYFFLKYASLEDIIYENVEIEDVEPIEAPFASNIKGHFDTIVTNNITEEDDEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAE--KVKTVFFGGNLFQSE-IFRKEYSYLKKVYTLDFVNFYFVNN-GHSGALGAMVSCPED 1307
            ++D G SLTK+ Y+      +A              D +P  +       T  L    F+N  ++  L  ++++    E + +    TG G  K+   I+E L   V   D      +G  F LK    E  +Y+    +D +P E  F +N           NI       FP +   +GSG   +++ ++  F         G  F G+   + +T  ++E++ +A++G   NVD   +DI         + G +     GK A  ++   EF+K D+A SL+ +   +  I  + C  A+   +  V+FGG   +   +  +  +Y    ++   V   F+ + G+ GA+GA +   E 
Sbjct:   38 AIDIGGSLTKLAYYSTVQHKVAKVRSFDHPGKDVEQDHEPPYEISVQEEITARLHFIKFENTYMEACLDFIRDHLVNTETKVI--QATGGGAYKFKDLIEEKLRLKVDKEDVMTCLIKGCNFVLKNIPHEAFMYQ----KDSDP-EFRFQTN---------HPNI-------FPYLLVNIGSGVSIVKVETEDRFEWIGGSSIGGGTFWGLGALLTKTKKFDELLQLASRGRHANVDMLVQDIYGGAHQTLGLSGNLIASSFGKSATADR---EFSKEDMAKSLLHMISND--IGQLACLYAKLHGLDRVYFGGFFIRGHPVTMRTITYSINFFSKGEVQALFLRHEGYLGAIGAFLKGAEQ 371

[Close]

BLAST of DUF89 domain-containing protein vs. Ensembl Mouse
Match: Pank4 (pantothenate kinase 4 [Source:MGI Symbol;Acc:MGI:2387466])

HSP 1 Score: 69.3218 bits (168), Expect = 4.387e-12
Identity = 83/362 (22.93%), Postives = 149/362 (41.16%), Query Frame = 3

Query:  297 SLDRGCSLTKVIYFDKSDKNLA--------------DEDPSID-------TVILTLALFDNNNLDEVLLILKENAYFPENQTLPFHVTGAGGDKYSKRIKEILERDVIFIDEYLSQARGTYFFLKYASLEDIIYENVEIEDVEPIEAPFASNIKGHFDTIVTNNITEEDDEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAE--KVKTVFFGGNLFQSE-IFRKEYSYLKKVYTLDFVNFYFVNN-GHSGALGAMVSCPED 1307
            ++D G SLTK+ Y+      +A              D +P  +       T  L    F+N  ++  L  ++++    E + +    TG G  K+   I+E L   V   D      +G  F LK    E  +Y+    +D +P E  F +N           NI       FP +   +GSG   +++ ++  F         G  F G+   + +T  ++E++ +A++G   NVD   +DI         + G +     GK A  ++   EF+K D+A SL+ +   +  I  + C  A+   +  V+FGG   +   +  +  +Y    ++   V   F+ + G+ GA+GA +   E 
Sbjct:   38 AIDIGGSLTKLAYYSTVQHKVAKVRSFDHPGKDVEQDHEPPYEISVQEEITARLHFIKFENTYMEACLDFIRDHLVNTETKVI--QATGGGAYKFKDLIEEKLRLKVDKEDVMTCLIKGCNFVLKNIPHEAFMYQ----KDSDP-EFRFQTN---------HPNI-------FPYLLVNIGSGVSIVKVETEDRFEWIGGSSIGGGTFWGLGALLTKTKKFDELLQLASRGRHANVDMLVQDIYGGAHQTLGLSGNLIASSFGKSATADR---EFSKEDMAKSLLHMISND--IGQLACLYAKLHGLDRVYFGGFFIRGHPVTMRTITYSINFFSKGEVQALFLRHEGYLGAIGAFLKGAEQ 371

[Close]

BLAST of DUF89 domain-containing protein vs. Ensembl Mouse
Match: Pank3 (pantothenate kinase 3 [Source:MGI Symbol;Acc:MGI:2387464])

HSP 1 Score: 67.781 bits (164), Expect = 6.661e-12
Identity = 47/193 (24.35%), Postives = 80/193 (41.45%), Query Frame = 3

Query:  741 DEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQSEIFRKEYSYLKKVYTLDFVN------FYFVNNGHSGALGAMVSCP 1301
            D+ +P +   +GSG   + ++S   +         G  F+G+C  +    ++EE ++MA+KGD    D    DI   D     +PG       G +    K     +K D+A + +     N    A  C + EK+  V F GN  +        S     Y LD+ +       +  + G+ GA+GA++  P
Sbjct:  180 DDPYPLLVVNIGSGVSILAVHSKDNYKRVTGTSLGGGTFLGLCSLLTGCESFEEALEMASKGDSTQADRLVRDIYGGDYERFGLPGWAVASSFGNMIYKEKR-ETVSKEDLARATLVTITNNIGSVARMCAVNEKINRVVFVGNFLRVNTL----SMKLLAYALDYWSKGQLKALFLEHEGYFGAVGALLGLP 367

[Close]

BLAST of DUF89 domain-containing protein vs. Ensembl Mouse
Match: Pank1 (pantothenate kinase 1 [Source:MGI Symbol;Acc:MGI:1922985])

HSP 1 Score: 66.2402 bits (160), Expect = 8.369e-12
Identity = 49/190 (25.79%), Postives = 79/190 (41.58%), Query Frame = 3

Query:  741 DEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQSEIFRKEYSYLKKVYTLDFVN------FYFVNNGHSGALGAMV 1292
            D  +P +   MGSG   + + S   +         G  F+G+C  +     +EE +DMAAKGD  NVD   +DI   D     + G       G +    K  S  +K D+A + +     N    A  C + E +  V F GN  +  +   +       Y +DF +       +  + G+ GA+GA++
Sbjct:   58 DNPYPMLLVNMGSGVSILAVYSKDNYKRVTGTSLGGGTFLGLCCLLTGCETFEEALDMAAKGDSTNVDKLVKDIYGGDYERFGLQGSAVASSFGNMMSKEKRES-ISKEDLARATLVTITNNIGSIARMCALNENIDRVVFVGNFLRINMVSMKL----LAYAMDFWSKGQLKALFLEHEGYFGAVGALL 242

[Close]

BLAST of DUF89 domain-containing protein vs. Ensembl Mouse
Match: Pank1 (pantothenate kinase 1 [Source:MGI Symbol;Acc:MGI:1922985])

HSP 1 Score: 65.855 bits (159), Expect = 2.934e-11
Identity = 49/190 (25.79%), Postives = 79/190 (41.58%), Query Frame = 3

Query:  741 DEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQSEIFRKEYSYLKKVYTLDFVN------FYFVNNGHSGALGAMV 1292
            D  +P +   MGSG   + + S   +         G  F+G+C  +     +EE +DMAAKGD  NVD   +DI   D     + G       G +    K  S  +K D+A + +     N    A  C + E +  V F GN  +  +   +       Y +DF +       +  + G+ GA+GA++
Sbjct:  180 DNPYPMLLVNMGSGVSILAVYSKDNYKRVTGTSLGGGTFLGLCCLLTGCETFEEALDMAAKGDSTNVDKLVKDIYGGDYERFGLQGSAVASSFGNMMSKEKRES-ISKEDLARATLVTITNNIGSIARMCALNENIDRVVFVGNFLRINMVSMKLL----AYAMDFWSKGQLKALFLEHEGYFGAVGALL 364

[Close]

BLAST of DUF89 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q8L5Y9|PANK2_ARATH (Pantothenate kinase 2 OS=Arabidopsis thaliana OX=3702 GN=PANK2 PE=1 SV=2)

HSP 1 Score: 77.7962 bits (190), Expect = 8.179e-14
Identity = 88/377 (23.34%), Postives = 151/377 (40.05%), Query Frame = 3

Query:  297 SLDRGCSLTKVIYFDKSDKNLADEDPSIDTVILTLAL-------------------FDNNNLDEVL------LILKENAYFPENQTLPF-----HVTGAGGDKYSKRIKEILERDVIFIDEYLSQARGTYFFLKYASLEDIIYENVEIEDVEPIEAPFASNIKGHFDTIVTNNITEEDDEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIP--LGKLADTNKDISEFNKNDIAHSLVSLFIYN----AMINAIHCCIAEKVKTVFFGGNLFQSEIFRKEYSYLKKVYTLDFVNF--YFVNNG--------HSGALGAM 1289
            +LD G SL K++YF + +    D+D    T+   L +                   F+ + ++E L       + + + Y   ++TLP       VTG G  K++   KE L   +   DE      G  F LK    E   +   E E                F  I  N++       +P +   +GSG   ++++ +G F         G  + G+ R + +  +++E+++++ KGD   +D    DI      Y KI    S I    GK    NK++ ++   DI+ SL+ +  YN    + +NA+   +    K +FFGG   +              YT+D ++F  +F + G        H G LGA+
Sbjct:   81 ALDIGGSLIKLLYFSRHEDYSNDDDKRKRTIKERLGITNGNLRSYPVLGGRLHFVKFETHKINECLDFIHSKQLHRRDPYPWSSKTLPLGTGVIKVTGGGAFKFADLFKERLGVSIEKEDEMHCLVSGANFLLKAIRHEAFTHMEGEKE----------------FVQIDPNDL-------YPYLLVNVGSGVSIIKVDGEGKFERVSGTNVGGGTYWGLGRLLTKCKSFDELLELSQKGDNSAIDMLVGDIYGG-MDYSKIGLSASTIASSFGKAISENKELDDYRPEDISLSLLRMISYNIGQISYLNALRFGL----KRIFFGGFFIRGH-----------AYTMDTISFAVHFWSKGEMQAMFLRHEGFLGAL 418

[Close]

BLAST of DUF89 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q923S8|PANK4_RAT (4'-phosphopantetheine phosphatase OS=Rattus norvegicus OX=10116 GN=Pank4 PE=1 SV=1)

HSP 1 Score: 69.707 bits (169), Expect = 2.461e-11
Identity = 83/362 (22.93%), Postives = 149/362 (41.16%), Query Frame = 3

Query:  297 SLDRGCSLTKVIYFDKSDKNLA--------------DEDPSID-------TVILTLALFDNNNLDEVLLILKENAYFPENQTLPFHVTGAGGDKYSKRIKEILERDVIFIDEYLSQARGTYFFLKYASLEDIIYENVEIEDVEPIEAPFASNIKGHFDTIVTNNITEEDDEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAE--KVKTVFFGGNLFQSE-IFRKEYSYLKKVYTLDFVNFYFVNN-GHSGALGAMVSCPED 1307
            ++D G SLTK+ Y+      +A              D +P  +       T  L    F+N  ++  L  ++++    E + +    TG G  K+   I+E L   V   D      +G  F LK    E  +Y+    +D +P E  F +N           NI       FP +   +GSG   +++ ++  F         G  F G+   + +T  ++E++ +A++G   NVD   +DI         + G +     GK A  ++   EF+K D+A SL+ +   +  I  + C  A+   +  V+FGG   +   +  +  +Y    ++   V   F+ + G+ GA+GA +   E 
Sbjct:   38 AIDIGGSLTKLAYYSTVQHKVAKVRSFDHPGKDAEQDHEPPYEISVQEEITARLHFIKFENTYMEACLDFIRDHLVNTETKVI--QATGGGAYKFKDLIEEKLRLKVDKEDVMTCLIKGCNFVLKNIPHEAFMYQ----KDSDP-EFRFQTN---------HPNI-------FPYLLVNIGSGVSIVKVETEDRFEWIGGSSIGGGTFWGLGALLTKTKKFDELLQLASRGRHANVDMLVQDIYGGAHQTLGLSGNLIASSFGKSATADR---EFSKEDMAKSLLHMISND--IGQLACLYAKLHGLDRVYFGGFFIRGHPVTMRTITYSINFFSKGEVQALFLRHEGYLGAIGAFLKGAEQ 371

[Close]

BLAST of DUF89 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9H999|PANK3_HUMAN (Pantothenate kinase 3 OS=Homo sapiens OX=9606 GN=PANK3 PE=1 SV=1)

HSP 1 Score: 68.5514 bits (166), Expect = 2.736e-11
Identity = 48/193 (24.87%), Postives = 81/193 (41.97%), Query Frame = 3

Query:  741 DEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQSEIFRKEYSYLKKVYTLDFVN------FYFVNNGHSGALGAMVSCP 1301
            D+ +P +   +GSG   + ++S   +         G  F+G+C  +    ++EE ++MA+KGD    D    DI   D     +PG       G +    K  S  +K D+A + +     N    A  C + EK+  V F GN  +        S     Y LD+ +       +  + G+ GA+GA++  P
Sbjct:  180 DDPYPLLVVNIGSGVSILAVHSKDNYKRVTGTSLGGGTFLGLCSLLTGCESFEEALEMASKGDSTQADKLVRDIYGGDYERFGLPGWAVASSFGNMIYKEKRES-VSKEDLARATLVTITNNIGSVARMCAVNEKINRVVFVGNFLRVNTL----SMKLLAYALDYWSKGQLKALFLEHEGYFGAVGALLGLP 367

[Close]

BLAST of DUF89 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q80YV4|PANK4_MOUSE (4'-phosphopantetheine phosphatase OS=Mus musculus OX=10090 GN=Pank4 PE=1 SV=2)

HSP 1 Score: 69.3218 bits (168), Expect = 3.069e-11
Identity = 83/362 (22.93%), Postives = 149/362 (41.16%), Query Frame = 3

Query:  297 SLDRGCSLTKVIYFDKSDKNLA--------------DEDPSID-------TVILTLALFDNNNLDEVLLILKENAYFPENQTLPFHVTGAGGDKYSKRIKEILERDVIFIDEYLSQARGTYFFLKYASLEDIIYENVEIEDVEPIEAPFASNIKGHFDTIVTNNITEEDDEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAE--KVKTVFFGGNLFQSE-IFRKEYSYLKKVYTLDFVNFYFVNN-GHSGALGAMVSCPED 1307
            ++D G SLTK+ Y+      +A              D +P  +       T  L    F+N  ++  L  ++++    E + +    TG G  K+   I+E L   V   D      +G  F LK    E  +Y+    +D +P E  F +N           NI       FP +   +GSG   +++ ++  F         G  F G+   + +T  ++E++ +A++G   NVD   +DI         + G +     GK A  ++   EF+K D+A SL+ +   +  I  + C  A+   +  V+FGG   +   +  +  +Y    ++   V   F+ + G+ GA+GA +   E 
Sbjct:   38 AIDIGGSLTKLAYYSTVQHKVAKVRSFDHPGKDVEQDHEPPYEISVQEEITARLHFIKFENTYMEACLDFIRDHLVNTETKVI--QATGGGAYKFKDLIEEKLRLKVDKEDVMTCLIKGCNFVLKNIPHEAFMYQ----KDSDP-EFRFQTN---------HPNI-------FPYLLVNIGSGVSIVKVETEDRFEWIGGSSIGGGTFWGLGALLTKTKKFDELLQLASRGRHANVDMLVQDIYGGAHQTLGLSGNLIASSFGKSATADR---EFSKEDMAKSLLHMISND--IGQLACLYAKLHGLDRVYFGGFFIRGHPVTMRTITYSINFFSKGEVQALFLRHEGYLGAIGAFLKGAEQ 371

[Close]

BLAST of DUF89 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q08DA5|PANK3_BOVIN (Pantothenate kinase 3 OS=Bos taurus OX=9913 GN=PANK3 PE=2 SV=1)

HSP 1 Score: 68.1662 bits (165), Expect = 3.855e-11
Identity = 47/193 (24.35%), Postives = 81/193 (41.97%), Query Frame = 3

Query:  741 DEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQSEIFRKEYSYLKKVYTLDFVN------FYFVNNGHSGALGAMVSCP 1301
            D+ +P +   +GSG   + ++S   +         G  F+G+C  +    ++EE ++MA+KGD    D    DI   D     +PG       G +    K  S  +K D+A + +     N    A  C + EK+  V F GN  +      +       Y LD+ +       +  + G+ GA+GA++  P
Sbjct:  180 DDPYPLLVVNIGSGVSILAVHSKDNYKRVTGTSLGGGTFLGLCSLLTGCESFEEALEMASKGDSTQADKLVRDIYGGDYERFGLPGWAVASSFGNMIYKEKRES-VSKEDLARATLVTITNNIGSIARMCAVNEKINRVVFVGNFLRVNTLSMKL----LAYALDYWSKGQLKALFLEHEGYFGAVGALLGLP 367

[Close]

BLAST of DUF89 domain-containing protein vs. TrEMBL
Match: A0A1I8HZ40 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig034563g2 PE=4 SV=1)

HSP 1 Score: 228.794 bits (582), Expect = 4.046e-67
Identity = 128/361 (35.46%), Postives = 205/361 (56.79%), Query Frame = 3

Query:  246 KKISFKKCFLNQVEVLASLDRGCSLTKVIYFDKSDKNLADEDPSIDTVILTLALFDNNNLDEVLLILKENAYFPENQTLPFHVTGAGGDKYSKRIKEILERDVIFIDEYLSQARGTYFFLKYASLEDIIYENVEIEDVEPIEAPFASNIKGHFDTIVTNNITEE-DDEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAAD--SPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQSEIFRKEYSYLKKVYTLDFVNFYFVNNGHSGALGAMVSCPEDVKKY 1319
            K I+ KK     V V+  LDRGC+LTKV++    D    DE  +     L  ALF N++ +  L  LKE     +      HVTGAG D + + IK+ L  ++ FI+E+L+Q RGT++ +  A   +I Y   E+ D+   E   A+N           ++ E  + +KFPC+   MGSG G M++  +G   M   +   G+ F+G+ + +L T++Y+EI+++A+KG R NVDT  +D++A D  SPYG++P  + + P GK  DT+K +++ ++ D+A+S+V  F YNA  N        K+  ++ GGN F+ E+ R E   + +++T + +   F+  GH+GA+GAM+S PED  KY
Sbjct:   10 KIIAVKKSHFEGVGVVGGLDRGCTLTKVLFSTVKD----DEHYN-----LHFALFKNSHFEAGLDYLKEKGMVVQVPGAKLHVTGAGCDMHRELIKQKLGLEIQFINEFLTQGRGTHWLIGCADDSEICYPEPEL-DMSEFEGLQANNFLQKLIEKAKKDLGEPIEGQKFPCMMLFMGSGGGIMKIEENGMSDMVGGLWFAGRSFLGLSKLLLGTDDYDEILELASKGRRNNVDTEVKDVLANDPNSPYGQLPPNLPVFPFGKAVDTDKTLADLSREDLANSIVFSFAYNAFTNLALAAQTSKIPKLYMGGNFFRHELIRAEILKIVRLFTGESIALKFLITGHTGAIGAMISKPEDEFKY 360

[Close]

BLAST of DUF89 domain-containing protein vs. TrEMBL
Match: A0A267H6I1 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig034563g1 PE=4 SV=1)

HSP 1 Score: 226.868 bits (577), Expect = 2.279e-66
Identity = 128/361 (35.46%), Postives = 204/361 (56.51%), Query Frame = 3

Query:  246 KKISFKKCFLNQVEVLASLDRGCSLTKVIYFDKSDKNLADEDPSIDTVILTLALFDNNNLDEVLLILKENAYFPENQTLPFHVTGAGGDKYSKRIKEILERDVIFIDEYLSQARGTYFFLKYASLEDIIYENVEIEDVEPIEAPFASNIKGHFDTIVTNNITEE-DDEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAAD--SPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQSEIFRKEYSYLKKVYTLDFVNFYFVNNGHSGALGAMVSCPEDVKKY 1319
            K I+ KK     V V+  LDRGC+LTKV++    D    DE  +     L  ALF N++ +  L  LKE     +      HVTGAG D + + IK+ L  ++ FI+E+L+Q RGT++ +  A   +I Y   E+ D+   E   A+N           ++ E  + +KFPC+   MGSG G M++  +G   M   +   G+ F+G+ + +L T++Y+EI+++A+KG R NVDT  +D++A D  SPYG++P  + + P GK  DT+K +++ ++ D+A+S+V  F YNA  N        K+  ++ GGN F+ E+ R E     +++T + +   F+  GH+GA+GAM+S PED  KY
Sbjct:   10 KIIAVKKSHFEGVGVVGGLDRGCTLTKVLFSTVKD----DEHYN-----LHFALFKNSHFEAGLDYLKEKGMVVQVPGAKLHVTGAGCDMHRELIKQKLGLEIQFINEFLTQGRGTHWLIGCADDSEICYPEPEL-DMSEFEGLQANNFLQKLIEKAKKDLGEPIEGQKFPCMMLFMGSGGGIMKIEENGMSDMVGGLWFAGRSFLGLSKLLLGTDDYDEILELASKGRRNNVDTEVKDVLANDPNSPYGQLPPNLPVFPFGKAVDTDKTLADLSREDLANSIVFSFAYNAFTNLALAAQTSKIPKLYMGGNFFRHELIRAEILKSVRLFTGESIALNFLITGHTGAIGAMISKPEDEFKY 360

[Close]

BLAST of DUF89 domain-containing protein vs. TrEMBL
Match: A0A1I8GL52 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 228.409 bits (581), Expect = 4.078e-63
Identity = 128/361 (35.46%), Postives = 205/361 (56.79%), Query Frame = 3

Query:  246 KKISFKKCFLNQVEVLASLDRGCSLTKVIYFDKSDKNLADEDPSIDTVILTLALFDNNNLDEVLLILKENAYFPENQTLPFHVTGAGGDKYSKRIKEILERDVIFIDEYLSQARGTYFFLKYASLEDIIYENVEIEDVEPIEAPFASNIKGHFDTIVTNNITEE-DDEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAAD--SPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQSEIFRKEYSYLKKVYTLDFVNFYFVNNGHSGALGAMVSCPEDVKKY 1319
            K I+ KK     V V+  LDRGC+LTKV++    D    DE  +     L  ALF N++ +  L  LKE     +      HVTGAG D + + IK+ L  ++ FI+E+L+Q RGT++ +  A   +I Y   E+ D+   E   A+N           ++ E  + +KFPC+   MGSG G M++  +G   M   +   G+ F+G+ + +L T++Y+EI+++A+KG R NVDT  +D++A D  SPYG++P  + + P GK  DT+K +++ ++ D+A+S+V  F YNA  N        K+  ++ GGN F+ E+ R E   + +++T + +   F+  GH+GA+GAM+S PED  KY
Sbjct:   10 KIIAVKKSHFEGVGVVGGLDRGCTLTKVLFSTVKD----DEHYN-----LHFALFKNSHFEAGLDYLKEKGMVVQVPGAKLHVTGAGCDMHRELIKQKLGLEIQFINEFLTQGRGTHWLIGCADDSEICYPEPEL-DMSEFEGLQANNFLQKLIEKAKKDLGEPIEGQKFPCMMLFMGSGGGIMKIEENGMSDMVGGLWFAGRSFLGLSKLLLGTDDYDEILELASKGRRNNVDTEVKDVLANDPNSPYGQLPPNLPVFPFGKAVDTDKTLADLSREDLANSIVFSFAYNAFTNLALAAQTSKIPKLYMGGNFFRHELIRAEILKIVRLFTGESIALKFLITGHTGAIGAMISKPEDEFKY 360

[Close]

BLAST of DUF89 domain-containing protein vs. TrEMBL
Match: A0A1I8HLA0 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 228.409 bits (581), Expect = 4.838e-63
Identity = 128/361 (35.46%), Postives = 205/361 (56.79%), Query Frame = 3

Query:  246 KKISFKKCFLNQVEVLASLDRGCSLTKVIYFDKSDKNLADEDPSIDTVILTLALFDNNNLDEVLLILKENAYFPENQTLPFHVTGAGGDKYSKRIKEILERDVIFIDEYLSQARGTYFFLKYASLEDIIYENVEIEDVEPIEAPFASNIKGHFDTIVTNNITEE-DDEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAAD--SPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQSEIFRKEYSYLKKVYTLDFVNFYFVNNGHSGALGAMVSCPEDVKKY 1319
            K I+ KK     V V+  LDRGC+LTKV++    D    DE  +     L  ALF N++ +  L  LKE     +      HVTGAG D + + IK+ L  ++ FI+E+L+Q RGT++ +  A   +I Y   E+ D+   E   A+N           ++ E  + +KFPC+   MGSG G M++  +G   M   +   G+ F+G+ + +L T++Y+EI+++A+KG R NVDT  +D++A D  SPYG++P  + + P GK  DT+K +++ ++ D+A+S+V  F YNA  N        K+  ++ GGN F+ E+ R E   + +++T + +   F+  GH+GA+GAM+S PED  KY
Sbjct:   10 KIIAVKKSHFEGVGVVGGLDRGCTLTKVLFSTVKD----DEHYN-----LHFALFKNSHFEAGLDYLKEKGMVVQVPGAKLHVTGAGCDMHRELIKQKLGLEIQFINEFLTQGRGTHWLIGCADDSEICYPEPEL-DMSEFEGLQANNFLQKLIEKAKKDLGEPIEGQKFPCMMLFMGSGGGIMKIEENGMSDMVGGLWFAGRSFLGLSKLLLGTDDYDEILELASKGRRNNVDTEVKDVLANDPNSPYGQLPPNLPVFPFGKAVDTDKTLADLSREDLANSIVFSFAYNAFTNLALAAQTSKIPKLYMGGNFFRHELIRAEILKIVRLFTGESIALKFLITGHTGAIGAMISKPEDEFKY 360

[Close]

BLAST of DUF89 domain-containing protein vs. TrEMBL
Match: A0A1I8G3I7 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 228.024 bits (580), Expect = 6.956e-63
Identity = 128/361 (35.46%), Postives = 205/361 (56.79%), Query Frame = 3

Query:  246 KKISFKKCFLNQVEVLASLDRGCSLTKVIYFDKSDKNLADEDPSIDTVILTLALFDNNNLDEVLLILKENAYFPENQTLPFHVTGAGGDKYSKRIKEILERDVIFIDEYLSQARGTYFFLKYASLEDIIYENVEIEDVEPIEAPFASNIKGHFDTIVTNNITEE-DDEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAAD--SPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQSEIFRKEYSYLKKVYTLDFVNFYFVNNGHSGALGAMVSCPEDVKKY 1319
            K I+ KK     V V+  LDRGC+LTKV++    D    DE  +     L  ALF N++ +  L  LKE     +      HVTGAG D + + IK+ L  ++ FI+E+L+Q RGT++ +  A   +I Y   E+ D+   E   A+N           ++ E  + +KFPC+   MGSG G M++  +G   M   +   G+ F+G+ + +L T++Y+EI+++A+KG R NVDT  +D++A D  SPYG++P  + + P GK  DT+K +++ ++ D+A+S+V  F YNA  N        K+  ++ GGN F+ E+ R E   + +++T + +   F+  GH+GA+GAM+S PED  KY
Sbjct:   10 KIIAVKKSHFEGVGVVGGLDRGCTLTKVLFSTVKD----DEHYN-----LHFALFKNSHFEAGLDYLKEKGMVVQVPGAKLHVTGAGCDMHRELIKQKLGLEIQFINEFLTQGRGTHWLIGCADDSEICYPEPEL-DMSEFEGLQANNFLQKLIEKAKKDLGEPIEGQKFPCMMLFMGSGGGIMKIEENGMSDMVGGLWFAGRSFLGLSKLLLGTDDYDEILELASKGRRNNVDTEVKDVLANDPNSPYGQLPPNLPVFPFGKAVDTDKTLADLSREDLANSIVFSFAYNAFTNLALAAQTSKIPKLYMGGNFFRHELIRAEILKIVRLFTGESIALKFLITGHTGAIGAMISKPEDEFKY 360

[Close]

BLAST of DUF89 domain-containing protein vs. Ensembl Cavefish
Match: pank4 (pantothenate kinase 4 (inactive) [Source:NCBI gene;Acc:103021954])

HSP 1 Score: 67.3958 bits (163), Expect = 1.547e-11
Identity = 85/364 (23.35%), Postives = 145/364 (39.84%), Query Frame = 3

Query:  297 SLDRGCSLTKVIYFD----------------KSDKNLADEDPSID-------TVILTLALFDNNNLDEVLLILKENAYFPENQTLPFHVTGAGGDKYSKRIKEILERDVIFIDEYLSQARGTYFFLKYASLEDIIYENVEIEDVEPIEAPFASNIKGHFDTIVTNNITEEDDEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAE--KVKTVFFGGNLFQSE-IFRKEYSYLKKVYTLDFVNFYFVNN-GHSGALGAMVSCPED 1307
            ++D G SLTK+ Y+                 K+    AD +P  +       T  L    F+N  ++  L  +K++    E + +    TG G  K+   I++ L+  V   DE     +G  F LK    E  +Y                     H D+      T  D   FP +   +GSG   +++ S+  F         G  F G+   + +T  ++E++ +A+KG   NVD   +DI         + G +     GK A  +K   EF++ D+A SL+ +   +  I  + C  A    +  V+FGG   +   +     +Y    +T   V   F+ + G+ GA+GA +   E+
Sbjct:   36 AIDIGGSLTKLAYYSTVQHKVAKVRSFDHTAKAGVQEADGEPLYEISVQEEITARLHFIKFENTYIETCLDFIKDHLVNTETKVI--KATGGGAYKFKDLIEKKLKLKVDKEDEMSCLIKGCNFVLKNIPHEAFVYAK-------------------HADSEFRFQNTRPD--IFPYLLVNIGSGVSIVKVESEDKFERIGGSSIGGGTFWGLGALLTKTKRFDELLQLASKGQHTNVDMLVKDIYGGAYGSLGLTGDLIASSFGKSATADK---EFSQEDMAKSLLHMISND--IGQLACLYARLHNLNRVYFGGFFIRGHPVTMHTITYSINFFTKGEVQALFLRHEGYLGAIGAFLKGAEE 371

[Close]

BLAST of DUF89 domain-containing protein vs. Ensembl Cavefish
Match: pank1b (pantothenate kinase 1 [Source:NCBI gene;Acc:103047703])

HSP 1 Score: 63.929 bits (154), Expect = 1.146e-10
Identity = 48/186 (25.81%), Postives = 82/186 (44.09%), Query Frame = 3

Query:  741 DEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQ-SEIFRKEYSYLKKVYTLDFVNFYFV-NNGHSGALGAMV 1292
            D  FP +   +GSG   + + S   +         G  F+G+C  +     +EE ++MAAKGD  NVD   +DI   D     + G       G +    +  S  +K D+A + +     N    A  C + EK++ V F GN  + + +  K  +Y    ++   +   F+ + G+ GA+GA +
Sbjct:  258 DNPFPMLLVNIGSGVSILAVYSKDNYKRVTGTSLGGGTFLGLCCLLTGCETFEEALEMAAKGDSTNVDKLVKDIYGGDYERFGLQGSAVASSFGHMMSKERRDS-ISKEDLARATLVTITNNIGSIARMCAVNEKIERVVFVGNFLRINTVSTKLLAYAMDFWSKGQLKALFLEHEGYFGAVGAFL 442

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BLAST of DUF89 domain-containing protein vs. Ensembl Cavefish
Match: pank1a (pantothenate kinase 1a [Source:ZFIN;Acc:ZDB-GENE-040426-2846])

HSP 1 Score: 62.7734 bits (151), Expect = 2.196e-10
Identity = 51/194 (26.29%), Postives = 84/194 (43.30%), Query Frame = 3

Query:  741 DEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQ-SEIFRKEYSYLKKVYTLDFVNFYFV-NNGHSGALGA---MVSCPED 1307
            D  FP +   +GSG   + + S G           G  F+G+C  +     +EE ++MA+KGD  N D    DI   D     + G       G +    K  S  +K D+A + +     N    A  C + EK++ V F GN  + + +  K  +Y    ++   +   F+ + G+ GA+GA   ++  PED
Sbjct:  165 DNPFPMLLVNIGSGVSILAVYSLG-----------GGTFLGLCCLLTGCETFEEALEMASKGDSTNADKLVRDIYGGDYQRFGLQGSAVASSFGHMMSKEKRDS-ISKEDLARATLVTITNNIGSIARMCAVNEKIERVVFVGNFLRINTVSTKLLAYAMDFWSRGQLRALFLEHEGYFGAVGAFLELLKSPED 346

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BLAST of DUF89 domain-containing protein vs. Ensembl Cavefish
Match: pank2 (pantothenate kinase 2 [Source:NCBI gene;Acc:103044193])

HSP 1 Score: 56.225 bits (134), Expect = 4.041e-8
Identity = 43/190 (22.63%), Postives = 78/190 (41.05%), Query Frame = 3

Query:  741 DEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQSEIFRKEYSYLKKVYTLDFVN------FYFVNNGHSGALGAMV 1292
            +  +P +   +GSG   + + S   +         G  F+G+C  +   + +EE ++MA++G+   VD    DI   D     +PG       G +    K  S  +K D+A + +     N       C + E ++ V F GN  +        S     Y LD+ +       +  + G+ GA+GA++
Sbjct:  248 ENPYPLLLVNIGSGVSILAVYSKDNYKRVTGTSLGGGTFLGLCCLLTGCSTFEEALEMASRGESTRVDKLVRDIYGGDYERFGLPGWAVASSFGNMMCKEKRDS-VSKEDLARATLVTITNNIGSITRMCALNENIERVVFVGNFLRVNTL----SMKLLAYALDYWSKGQLKALFLRHEGYFGAVGALL 432

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BLAST of DUF89 domain-containing protein vs. Ensembl Sea Lamprey
Match: pank2 (pantothenate kinase 2 [Source:ZFIN;Acc:ZDB-GENE-070112-1952])

HSP 1 Score: 58.5362 bits (140), Expect = 9.681e-10
Identity = 40/184 (21.74%), Postives = 87/184 (47.28%), Query Frame = 3

Query:  747 KFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQ-SEIFRKEYSYLKKVYTLDFVNFYFV-NNGHSGALGAMV 1292
            ++P +   +GSG   + + S   +         G  F+G+C  +   ++++E + +A +GD  NVD    DI   D     + G       G++   ++     +K D+A + +     N    A  C + EK++ V F GN  + +++ R+  ++  + ++   +  +F+ + G+ GA+GA++
Sbjct:  182 RYPLLLVNIGSGVSMLAVYSPHDYRRVTGTSLGGGTFLGLCCLLTGCDSFDEALSLAERGDSTNVDKLVRDIYGGDYERFGLRGSAVASSFGQMISLDRR-EAVSKEDLAMATLVTITNNIGSIARMCALNEKMERVVFVGNFLRVNQLSRRLLAHAMEYWSGGQLKAFFLEHEGYFGAVGALL 364

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BLAST of DUF89 domain-containing protein vs. Ensembl Sea Lamprey
Match: pank2 (pantothenate kinase 2 [Source:ZFIN;Acc:ZDB-GENE-070112-1952])

HSP 1 Score: 54.299 bits (129), Expect = 2.561e-8
Identity = 41/183 (22.40%), Postives = 78/183 (42.62%), Query Frame = 3

Query:  750 FPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQ-SEIFRKEYSYLKKVYTLDFVNFYFV-NNGHSGALGAMV 1292
            +P +   +GSG   + ++S   +         G  F+G+   +     +EE + +A +GD  NVD    DI   D     +PG       G +    +     ++ D+A + +     N    A  C + EK+  V F GN  + + +  K  +Y    ++   +   F+ + G+ GA+GA++
Sbjct:  183 YPLLLVNIGSGVSILAVHSPNNYKRVTGTSLGGGTFLGLSCLLTGCKTFEEALSLAERGDSTNVDKLVRDIYGGDYGRFGLPGSTVASSFGNMMCKERR-EAVSREDLARATLVTITNNIGSIARMCALNEKIDRVVFVGNFLRVNTLSMKLLAYAMDYWSKGQLKALFLEHEGYFGAVGALL 364

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BLAST of DUF89 domain-containing protein vs. Ensembl Nematostella
Match: EDO37713 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SEX1])

HSP 1 Score: 72.4034 bits (176), Expect = 5.173e-14
Identity = 65/270 (24.07%), Postives = 110/270 (40.74%), Query Frame = 3

Query:  492 VTGAGGDKYSKRIKEILERDVIFIDEYLSQARGTYFFLKYASLEDIIYENVEIEDV-EPIEAPFASNIKGHFDTIVTNNITEEDDEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQS-EIFRKEYSYLKKVYTLDFVNFYFVNN-GHSGALGAMV 1292
             TG G  K+    KE+L   ++  DE      G +F   +   E   +   +   + +  + P+                   D + FP +   +GSG   M + S   F         G  F+G+C  +     +EE + MAA+GD   VD   +DI   D     +PG       GK+    +  +E N  DIA + + +   N    A  C +  K++ V F GN  ++ EI  K  +Y    ++   +   F+ + G+ GA+GA++
Sbjct:  105 ATGGGAFKFEHDFKEVLGVQLVKYDELECLIHGIHFINDHFHQECYYWTWGDQYSIAQATKVPYGF-----------------DSDPFPYLVVNIGSGVSIMAVYSAEKFDRISGTSLGGGTFLGLCCLMTGCTTFEEALSMAARGDSTKVDKLVKDIYGGDYNKFNLPGDTVASSFGKMCYPERQ-NEVNNEDIASATLIMITNNIGSIARMCAVNAKIERVVFVGNFLRTNEIAMKLLAYAMDYWSQGTMKALFLQHEGYFGAVGALL 356

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BLAST of DUF89 domain-containing protein vs. Ensembl Medaka
Match: pank4 (pantothenate kinase 4 (inactive) [Source:NCBI gene;Acc:101161916])

HSP 1 Score: 71.633 bits (174), Expect = 7.390e-13
Identity = 87/360 (24.17%), Postives = 145/360 (40.28%), Query Frame = 3

Query:  297 SLDRGCSLTKVIYFD---------KSDKNLADEDPSID----------TVILTLALFDNNNLDEVLLILKENAYFPENQTLPFHVTGAGGDKYSKRIKEILERDVIFIDEYLSQARGTYFFLKYASLEDIIYENVEIEDVEPIEAPFASNIKGHFDTIVTNNITEEDDEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAE--KVKTVFFGGNLFQSE-IFRKEYSYLKKVYTLDFVNFYFVNN-GHSGALGAMVSCPED 1307
            ++D G SLTK+ Y+          +S  + A E PS            T  L    F+N  ++  L  +K++    E + +    TG G  K+ + I++ L   V   DE     +G  F LK    E  +Y                     H D+      T  D   FP +   +GSG   +++ S+  F         G  F G+   + +T  ++E++ +A+KG   NVD   +DI         + G +     GK A  +KD   F K D+A SL+ +   +  I  + C  A+   +  V+FGG   +   +     +Y    +T   V   F+ + G+ GA+GA +   E+
Sbjct:   34 AIDIGGSLTKLAYYSTVQHKVAKVRSFDHTAKEAPSDKLYEISMQEEVTARLHFIKFENAYIETCLDFIKDHLVNTETKVI--KATGGGAHKFKELIEKKLGLKVDKEDEMTCLIKGCNFVLKNIPHEAFVYAR-------------------HADSEFRFQTTNPD--IFPYLLVNIGSGVSIVKVESEDKFERIGGSSIGGGTFWGLGALLTKTKRFDELLQLASKGQHTNVDMLVKDIYGGSYGCLGLTGDLIASSFGKSATADKD---FCKEDMAKSLLHMISND--IGQLACLYAKLHGLSRVYFGGFFIRGHPVTMHTITYSINFFTKGEVQALFLRHEGYLGAIGAFLKGAEE 365

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BLAST of DUF89 domain-containing protein vs. Ensembl Medaka
Match: pank1a (pantothenate kinase 1 [Source:NCBI gene;Acc:101175261])

HSP 1 Score: 65.0846 bits (157), Expect = 4.747e-11
Identity = 48/186 (25.81%), Postives = 85/186 (45.70%), Query Frame = 3

Query:  741 DEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQ-SEIFRKEYSYLKKVYTLDFVNFYFV-NNGHSGALGAMV 1292
            D  FP +   +GSG   + + S+  +         G  F+G+C  +     +EE ++MA+KGD +NVD   +DI   D     + G       G +    K  S  +K D+A + +     N    A  C + EK++ V F GN  + + +  K  +Y    ++   +   F+ + G+ GA+GA++
Sbjct:  259 DNPFPMLLVNIGSGVSVLAVYSEDNYKRVTGTSLGGGTFLGLCCLLTGCETFEEALEMASKGDSKNVDKLVKDIYGGDYERFGLQGSAVASSFGHMMCKEKRDS-ISKEDLARATLVTITNNIGSIARMCAVNEKIERVVFVGNFLRINTVSTKLLAYAMDFWSKGQLRALFLEHEGYFGAVGALM 443

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BLAST of DUF89 domain-containing protein vs. Ensembl Medaka
Match: pank1a (pantothenate kinase 1 [Source:NCBI gene;Acc:101175261])

HSP 1 Score: 60.8474 bits (146), Expect = 1.138e-9
Identity = 40/147 (27.21%), Postives = 65/147 (44.22%), Query Frame = 3

Query:  741 DEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQ 1181
            D  FP +   +GSG   + + S+  +         G  F+G+C  +     +EE ++MA+KGD +NVD   +DI   D     + G       G +    K  S  +K D+A + +     N    A  C + EK++ V F GN  +
Sbjct:  259 DNPFPMLLVNIGSGVSVLAVYSEDNYKRVTGTSLGGGTFLGLCCLLTGCETFEEALEMASKGDSKNVDKLVKDIYGGDYERFGLQGSAVASSFGHMMCKEKRDS-ISKEDLARATLVTITNNIGSIARMCAVNEKIERVVFVGNFLR 404

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BLAST of DUF89 domain-containing protein vs. Ensembl Medaka
Match: pank2 (pantothenate kinase 3 [Source:NCBI gene;Acc:101161204])

HSP 1 Score: 59.3066 bits (142), Expect = 3.082e-9
Identity = 60/300 (20.00%), Postives = 124/300 (41.33%), Query Frame = 3

Query:  408 FDNNNLDEVLLILKENAYFPENQTLPFHVTGAGGDKYSKRIKEILERDVIFIDEYLSQARGTYFF---LKYASLEDIIYENVEIEDVEPIEAPFASNIKGHFDTIVTNNITEEDDEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQ-SEIFRKEYSYLKKVYTLDFVNFYFVNN-GHSGALGAMV 1292
            F  ++L   L + ++  +   + TL    TG G  K+    + + + ++  +DE     RG  +    + + + E   +EN   +  + ++ P+              N+    +  +P +   +GSG   + + S+  +         G  F+G+C  +   + +EE + MA++G+   VD    DI   D     +PG       G +    K  S  +K D+A + +     N       C + E ++ V F GN  + + +  K  +Y    ++   +   F+ + G+ GA+GA++
Sbjct:   84 FPTHDLPAFLQMGRDKHFSSLHTTLC--ATGGGAYKFESDFRRMADLELHKLDELDCLVRGVLYIDSVVSWGASECYYFEN-PTDPEQCVQKPY--------------NL----ENPYPLLLVNIGSGVSILAVYSENNYKRVTGTSLGGGTFLGLCCLLTGCSTFEEALQMASEGESTRVDKLVRDIYGGDYERFGLPGWAVASSFGNMMSKEKRES-VSKEDLARATLVTITNNIGSITRMCALNESIERVVFVGNFLRVNTLSMKLLAYAMDYWSKGQLKALFLRHEGYFGAVGALL 361

[Close]

BLAST of DUF89 domain-containing protein vs. Ensembl Medaka
Match: pank2 (pantothenate kinase 3 [Source:NCBI gene;Acc:101161204])

HSP 1 Score: 58.5362 bits (140), Expect = 6.829e-9
Identity = 55/272 (20.22%), Postives = 112/272 (41.18%), Query Frame = 3

Query:  492 VTGAGGDKYSKRIKEILERDVIFIDEYLSQARGTYFF---LKYASLEDIIYENVEIEDVEPIEAPFASNIKGHFDTIVTNNITEEDDEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQ-SEIFRKEYSYLKKVYTLDFVNFYFVNN-GHSGALGAMV 1292
             TG G  K+    + + + ++  +DE     RG  +    + + + E   +EN   +  + ++ P+              N+    +  +P +   +GSG   + + S+  +         G  F+G+C  +   + +EE + MA++G+   VD    DI   D     +PG       G +    K  S  +K D+A + +     N       C + E ++ V F GN  + + +  K  +Y    ++   +   F+ + G+ GA+GA++
Sbjct:  170 ATGGGAYKFESDFRRMADLELHKLDELDCLVRGVLYIDSVVSWGASECYYFEN-PTDPEQCVQKPY--------------NL----ENPYPLLLVNIGSGVSILAVYSENNYKRVTGTSLGGGTFLGLCCLLTGCSTFEEALQMASEGESTRVDKLVRDIYGGDYERFGLPGWAVASSFGNMMSKEKRES-VSKEDLARATLVTITNNIGSITRMCALNESIERVVFVGNFLRVNTLSMKLLAYAMDYWSKGQLKALFLRHEGYFGAVGALL 421

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BLAST of DUF89 domain-containing protein vs. Planmine SMEST
Match: SMESG000008042.1 (SMESG000008042.1)

HSP 1 Score: 747.273 bits (1928), Expect = 0.000e+0
Identity = 364/366 (99.45%), Postives = 365/366 (99.73%), Query Frame = 3

Query:  228 MPPIVVKKISFKKCFLNQVEVLASLDRGCSLTKVIYFDKSDKNLADEDPSIDTVILTLALFDNNNLDEVLLILKENAYFPENQTLPFHVTGAGGDKYSKRIKEILERDVIFIDEYLSQARGTYFFLKYASLEDIIYENVEIEDVEPIEAPFASNIKGHFDTIVTNNITEEDDEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQSEIFRKEYSYLKKVYTLDFVNFYFVNNGHSGALGAMVSCPEDVKKYKK 1325
            MPPIVVKKISFKKCFLNQVEVLASLDRGCSLTKVIYFDKSDKNLADEDPSIDTVILTLALFDNNNLDEVLLILKENAYFPENQTLPFHVTGAGGDKYSKRIKEILERDVIFIDEYLSQARGTYFFLKYASLEDIIYENVEIEDVEPIEAPFASNIKGHFDTIVTNNITEEDDEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIV ADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQSEIFRKEYSYL+KVYTLDFVNFYFVNNGHSGALGAMVSCPEDVKKYKK
Sbjct:    1 MPPIVVKKISFKKCFLNQVEVLASLDRGCSLTKVIYFDKSDKNLADEDPSIDTVILTLALFDNNNLDEVLLILKENAYFPENQTLPFHVTGAGGDKYSKRIKEILERDVIFIDEYLSQARGTYFFLKYASLEDIIYENVEIEDVEPIEAPFASNIKGHFDTIVTNNITEEDDEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVTADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQSEIFRKEYSYLRKVYTLDFVNFYFVNNGHSGALGAMVSCPEDVKKYKK 366

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BLAST of DUF89 domain-containing protein vs. Planmine SMEST
Match: SMESG000008043.1 (SMESG000008043.1)

HSP 1 Score: 397.127 bits (1019), Expect = 2.272e-136
Identity = 194/363 (53.44%), Postives = 268/363 (73.83%), Query Frame = 3

Query:  234 PIVVKKISFKKCFLNQVEVLASLDRGCSLTKVIYFDKSDKNLADEDPSIDTVILTLALFDNNNLDEVLLILKENAYFPENQTLPFHVTGAGGDKYSKRIKEILERDVIFIDEYLSQARGTYFFLKYASLEDIIYENVEIEDVEPIEAPFASNIKGHFDTIVTNNI-TEEDDEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQSEIFRKEYSYLKKVYTLDFVNFYFVNNGHSGALGAMVSCPEDVKKY 1319
            PI+ +K SFKK  L+ +EVLA LDRGCSLTK+IY DK D +  DE+ + D +ILT+ALF N+  D+ L+ LK+ A+FPEN+ LP H+TGAGG KYS++IKEIL+RDV+F+DE++SQ+RG Y+ L    L ++ Y  +E +  +  + PF +++K  F+ IV      +  ++  PCIF  +GSG G   + SDGTF M   +   GK FIG+ RCIL TN+Y EIM+MA++GDRRNVD   +DI+  D  + K+   + +I +GKLA+T K I+EFNK+D+AHSLVS+FIYNA+  AIH C++EKV  VFFGGNLFQSE+FRKE+S LKK+++++F+NFYFV+NGH+GALGAMV  P D++KY
Sbjct:    7 PIMERKFSFKKSVLSHIEVLAGLDRGCSLTKIIYVDKKDSDKVDENSTSDVIILTVALFLNSKFDDALIWLKDKAFFPENKELPIHLTGAGGVKYSEKIKEILDRDVVFVDEFMSQSRGAYYMLANVPLSEVTYAEIETDTTDWFDVPFITDVKIQFEEIVGKRKDVKTTEDLLPCIFGFIGSGGGFTYIGSDGTFRMVSGLPAAGKTFIGLSRCILGTNDYNEIMEMASRGDRRNVDLQVKDIM-GDESFEKLSPELPIIHMGKLAETKKSITEFNKDDLAHSLVSMFIYNAINAAIHVCMSEKVHNVFFGGNLFQSEVFRKEFSTLKKMFSVNFINFYFVSNGHTGALGAMVCSPNDMEKY 368

[Close]

BLAST of DUF89 domain-containing protein vs. Planmine SMEST
Match: SMESG000008043.1 (SMESG000008043.1)

HSP 1 Score: 392.889 bits (1008), Expect = 6.860e-135
Identity = 192/359 (53.48%), Postives = 265/359 (73.82%), Query Frame = 3

Query:  246 KKISFKKCFLNQVEVLASLDRGCSLTKVIYFDKSDKNLADEDPSIDTVILTLALFDNNNLDEVLLILKENAYFPENQTLPFHVTGAGGDKYSKRIKEILERDVIFIDEYLSQARGTYFFLKYASLEDIIYENVEIEDVEPIEAPFASNIKGHFDTIVTNNI-TEEDDEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQSEIFRKEYSYLKKVYTLDFVNFYFVNNGHSGALGAMVSCPEDVKKY 1319
            +K SFKK  L+ +EVLA LDRGCSLTK+IY DK D +  DE+ + D +ILT+ALF N+  D+ L+ LK+ A+FPEN+ LP H+TGAGG KYS++IKEIL+RDV+F+DE++SQ+RG Y+ L    L ++ Y  +E +  +  + PF +++K  F+ IV      +  ++  PCIF  +GSG G   + SDGTF M   +   GK FIG+ RCIL TN+Y EIM+MA++GDRRNVD   +DI+  D  + K+   + +I +GKLA+T K I+EFNK+D+AHSLVS+FIYNA+  AIH C++EKV  VFFGGNLFQSE+FRKE+S LKK+++++F+NFYFV+NGH+GALGAMV  P D++KY
Sbjct:    3 RKFSFKKSVLSHIEVLAGLDRGCSLTKIIYVDKKDSDKVDENSTSDVIILTVALFLNSKFDDALIWLKDKAFFPENKELPIHLTGAGGVKYSEKIKEILDRDVVFVDEFMSQSRGAYYMLANVPLSEVTYAEIETDTTDWFDVPFITDVKIQFEEIVGKRKDVKTTEDLLPCIFGFIGSGGGFTYIGSDGTFRMVSGLPAAGKTFIGLSRCILGTNDYNEIMEMASRGDRRNVDLQVKDIM-GDESFEKLSPELPIIHMGKLAETKKSITEFNKDDLAHSLVSMFIYNAINAAIHVCMSEKVHNVFFGGNLFQSEVFRKEFSTLKKMFSVNFINFYFVSNGHTGALGAMVCSPNDMEKY 360

[Close]

BLAST of DUF89 domain-containing protein vs. Planmine SMEST
Match: SMESG000077416.1 (SMESG000077416.1)

HSP 1 Score: 184.111 bits (466), Expect = 1.094e-53
Identity = 109/369 (29.54%), Postives = 192/369 (52.03%), Query Frame = 3

Query:  228 MPPIVVKKISFKKCFLNQVEVLASLDRGCSLTKVIYFDKSDK-NLADEDPSIDTVILTLALFDNNNLDEVLLILKENAYFPENQTLPFHVTGAGGDKYSKRIKEILERDVIFIDEYLSQARGTYFFLKYASLEDIIYENVEIEDVEPIEAPFASNIKGHFDTIVTNNITEEDDEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAAD--SPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQSEIFRKEYSYLKKVYTLDFVNFYFVNNGHSGALGAMVSCPEDVKKYKK 1325
            + PI    ++FKKC L +  +L  +D G SL+K I+ +K ++  L DE  S   +    ++F N ++++ L  LKENAY  E      H TG G  +  K+I+   E  +IF+ E L+   G    L++  LE++I+     +++  I+      +       +  +        +P +    GSG+     + DG      +  + GK F+GM +C++++N+Y+EI+  A+KG+R+N+DT  +DI+ +D  SPYGK P  + +   GK A+ N+D+  ++K+D+A SL+ L       N  +  +  K K ++  GN F+S +F KE       + +  V + F++ G++ ALGAM    ++   Y K
Sbjct:    3 IKPIKTGLVNFKKCNLLENRILIGIDIGSSLSKFIFVNKQNRCQLYDE--STHHINFQYSIFKNEDIEKALEWLKENAYIQEGTRYEIHCTGTGCLRNKKQIESTFELGLIFVQEGLALIAGHKIALEHCPLENLIHPPTSADELYEIDNNILKTMLTRMQKRINTDTNSNKTSLYPFVLGYWGSGSSIFFFDDDGKAQQIGSFQNGGKSFLGMAKCLIDSNDYDEIIASASKGNRKNIDTLIKDILISDEKSPYGKFPPELPVFQFGKCAENNQDLKYYSKDDLAMSLICLESSQISSNCRNAALTTKTKKIYLSGNTFKSSLFHKEILNRNLRHPIG-VEYTFLDLGYATALGAMFCVNQERAMYVK 368

[Close]

BLAST of DUF89 domain-containing protein vs. Planmine SMEST
Match: SMESG000031677.1 (SMESG000031677.1)

HSP 1 Score: 171.014 bits (432), Expect = 6.792e-49
Identity = 114/357 (31.93%), Postives = 194/357 (54.34%), Query Frame = 3

Query:  228 MPPIVVKKISFKKCFLNQVEVLASLDRGCSLTKVIYFDKSDKNLADEDPSIDTVILTLALFDNNNLDEVLLILKENAYFPENQTLPFHVTGAGGDKYSKRIKEILERDVIFIDEYLSQARGTYFFLKYASLEDIIYENVEIEDVEPIEAPFASNIKGHFDTIVTNNITEEDDEKFPCIFAIMGSGAGCMRLNSDGTFHMACNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIV--AADSPYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIHCCIAEKVKTVFFGGNLFQSEIFRKEYSYLKKVYTLDFVNFYFVNNGHSGALGAMV 1292
            MPP+  + I+ KK    +  +L S+D G SLTK+++ +K    L  ++    +++L   LF N++ D  L ++K +AYFPEN     +VTG    K  ++IK  L  + IFIDE+L+ A    F +++  +++++                 SNI       + N  +    + +P +F I GS +GC   ++D T + +  +   GK F+G+ +CIL TN+Y+EI+ +A +G++ NVDT  +++     DS Y ++P  +S+   GK  D NK + +F+K+D+A SL+S      ++ A   C  +KV  ++  GN+F SEIF+KE    +  +    V    +N G+ GALGAM+
Sbjct:    1 MPPLKTEFITVKKSKWIKNRLLISIDSGNSLTKLLFLNKMHYYLL-KNKEEASILLNFILFKNSDFDCALELVKNSAYFPENNNFNLYVTGVFALKNLEKIKFNLGINTIFIDEFLTIAESHRFLVEHIGVDNLLANKF-----------MESNINK-----INNQSSSIMPDLYPKLFHIHGSSSGCFYFSNDITEYWSI-LHQGGKTFLGLAKCILNTNDYDEIVSLATQGNKCNVDTQVKEMFDQTIDSTY-ELPSEMSIFSYGKCMDLNKGLRDFSKHDLAASLISYHAKFIIMFAASICSIKKVSKIYLTGNIFNSEIFQKEIVQFESNFPFA-VKPIILNFGYFGALGAML 337

The following BLAST results are available for this feature:

BLAST of DUF89 domain-containing protein vs. Ensembl Human
BLAST of DUF89 domain-containing protein vs. Ensembl Celegans
BLAST of DUF89 domain-containing protein vs. Ensembl Fly
BLAST of DUF89 domain-containing protein vs. Ensembl Zebrafish
BLAST of DUF89 domain-containing protein vs. Ensembl Xenopus
BLAST of DUF89 domain-containing protein vs. Ensembl Mouse
BLAST of DUF89 domain-containing protein vs. UniProt/SwissProt
BLAST of DUF89 domain-containing protein vs. TrEMBL
BLAST of DUF89 domain-containing protein vs. Ensembl Cavefish
BLAST of DUF89 domain-containing protein vs. Ensembl Sea Lamprey
BLAST of DUF89 domain-containing protein vs. Ensembl Yeast
BLAST of DUF89 domain-containing protein vs. Ensembl Nematostella
BLAST of DUF89 domain-containing protein vs. Ensembl Medaka
BLAST of DUF89 domain-containing protein vs. Planmine SMEST

BLAST of DUF89 domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
PANK3	5.697e-12	24.87	pantothenate kinase 3 [Source:HGNC Symbol;Acc:HGNC...	[more]
PANK1	1.830e-10	25.26	pantothenate kinase 1 [Source:HGNC Symbol;Acc:HGNC...	[more]
PANK1	3.744e-9	25.79	pantothenate kinase 1 [Source:HGNC Symbol;Acc:HGNC...	[more]
PANK2	2.913e-8	23.50	pantothenate kinase 2 [Source:HGNC Symbol;Acc:HGNC...	[more]
PANK2	2.913e-8	23.50	pantothenate kinase 2 [Source:HGNC Symbol;Acc:HGNC...	[more]

BLAST of DUF89 domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
pnk-1	2.938e-11	23.78	PaNtothenate Kinase [Source:UniProtKB/TrEMBL;Acc:...	[more]
pnk-1	2.938e-11	23.78	PaNtothenate Kinase [Source:UniProtKB/TrEMBL;Acc:...	[more]
pnk-1	7.778e-11	24.15	PaNtothenate Kinase [Source:UniProtKB/TrEMBL;Acc:...	[more]
pnk-1	1.075e-7	24.68	PaNtothenate Kinase [Source:UniProtKB/TrEMBL;Acc:...	[more]
pnk-4	1.729e-7	21.36	Pantothenate kinase [Source:UniProtKB/TrEMBL;Acc:...	[more]

BLAST of DUF89 domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
fbl	2.796e-11	22.88	gene:FBgn0011205 transcript:FBtr0307392	[more]
fbl	4.047e-11	25.27	gene:FBgn0011205 transcript:FBtr0078190	[more]
fbl	4.047e-11	25.27	gene:FBgn0011205 transcript:FBtr0078189	[more]
fbl	4.053e-11	25.27	gene:FBgn0011205 transcript:FBtr0078186	[more]
fbl	4.269e-11	25.27	gene:FBgn0011205 transcript:FBtr0307393	[more]

BLAST of DUF89 domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
pank4	9.398e-13	24.73	pantothenate kinase 4 (inactive) [Source:ZFIN;Acc:...	[more]
pank4	9.398e-13	24.73	pantothenate kinase 4 (inactive) [Source:ZFIN;Acc:...	[more]
pank1a	1.410e-11	26.34	pantothenate kinase 1a [Source:ZFIN;Acc:ZDB-GENE-0...	[more]
pank1a	2.104e-11	26.34	pantothenate kinase 1a [Source:ZFIN;Acc:ZDB-GENE-0...	[more]
pank1a	2.104e-11	26.34	pantothenate kinase 1a [Source:ZFIN;Acc:ZDB-GENE-0...	[more]

BLAST of DUF89 domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
pank3	6.937e-13	24.87	pantothenate kinase 3 [Source:NCBI gene;Acc:100135...	[more]
ca1	1.046e-9	23.35	carbonic anhydrase I [Source:Xenbase;Acc:XB-GENE-9...	[more]
ca1	1.125e-9	23.35	carbonic anhydrase I [Source:Xenbase;Acc:XB-GENE-9...	[more]
ca1	1.788e-9	25.26	carbonic anhydrase I [Source:Xenbase;Acc:XB-GENE-9...	[more]
cidea	5.706e-9	26.53	cell death inducing DFFA like effector a [Source:X...	[more]

BLAST of DUF89 domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Pank4	3.774e-12	22.93	pantothenate kinase 4 [Source:MGI Symbol;Acc:MGI:2...	[more]
Pank4	4.387e-12	22.93	pantothenate kinase 4 [Source:MGI Symbol;Acc:MGI:2...	[more]
Pank3	6.661e-12	24.35	pantothenate kinase 3 [Source:MGI Symbol;Acc:MGI:2...	[more]
Pank1	8.369e-12	25.79	pantothenate kinase 1 [Source:MGI Symbol;Acc:MGI:1...	[more]
Pank1	2.934e-11	25.79	pantothenate kinase 1 [Source:MGI Symbol;Acc:MGI:1...	[more]

BLAST of DUF89 domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q8L5Y9\|PANK2_ARATH	8.179e-14	23.34	Pantothenate kinase 2 OS=Arabidopsis thaliana OX=3...	[more]
sp\|Q923S8\|PANK4_RAT	2.461e-11	22.93	4'-phosphopantetheine phosphatase OS=Rattus norveg...	[more]
sp\|Q9H999\|PANK3_HUMAN	2.736e-11	24.87	Pantothenate kinase 3 OS=Homo sapiens OX=9606 GN=P...	[more]
sp\|Q80YV4\|PANK4_MOUSE	3.069e-11	22.93	4'-phosphopantetheine phosphatase OS=Mus musculus ...	[more]
sp\|Q08DA5\|PANK3_BOVIN	3.855e-11	24.35	Pantothenate kinase 3 OS=Bos taurus OX=9913 GN=PAN...	[more]

BLAST of DUF89 domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A1I8HZ40	4.046e-67	35.46	Uncharacterized protein OS=Macrostomum lignano OX=...	[more]
A0A267H6I1	2.279e-66	35.46	Uncharacterized protein OS=Macrostomum lignano OX=...	[more]
A0A1I8GL52	4.078e-63	35.46	Uncharacterized protein OS=Macrostomum lignano OX=...	[more]
A0A1I8HLA0	4.838e-63	35.46	Uncharacterized protein OS=Macrostomum lignano OX=...	[more]
A0A1I8G3I7	6.956e-63	35.46	Uncharacterized protein OS=Macrostomum lignano OX=...	[more]

BLAST of DUF89 domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 4


Match Name	E-value	Identity	Description
pank4	1.547e-11	23.35	pantothenate kinase 4 (inactive) [Source:NCBI gene...	[more]
pank1b	1.146e-10	25.81	pantothenate kinase 1 [Source:NCBI gene;Acc:103047...	[more]
pank1a	2.196e-10	26.29	pantothenate kinase 1a [Source:ZFIN;Acc:ZDB-GENE-0...	[more]
pank2	4.041e-8	22.63	pantothenate kinase 2 [Source:NCBI gene;Acc:103044...	[more]

BLAST of DUF89 domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2


Match Name	E-value	Identity	Description
pank2	9.681e-10	21.74	pantothenate kinase 2 [Source:ZFIN;Acc:ZDB-GENE-07...	[more]
pank2	2.561e-8	22.40	pantothenate kinase 2 [Source:ZFIN;Acc:ZDB-GENE-07...	[more]

BLAST of DUF89 domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of DUF89 domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1


Match Name	E-value	Identity	Description
EDO37713	5.173e-14	24.07	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of DUF89 domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
pank4	7.390e-13	24.17	pantothenate kinase 4 (inactive) [Source:NCBI gene...	[more]
pank1a	4.747e-11	25.81	pantothenate kinase 1 [Source:NCBI gene;Acc:101175...	[more]
pank1a	1.138e-9	27.21	pantothenate kinase 1 [Source:NCBI gene;Acc:101175...	[more]
pank2	3.082e-9	20.00	pantothenate kinase 3 [Source:NCBI gene;Acc:101161...	[more]
pank2	6.829e-9	20.22	pantothenate kinase 3 [Source:NCBI gene;Acc:101161...	[more]

BLAST of DUF89 domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000008042.1	0.000e+0	99.45	SMESG000008042.1	[more]
SMESG000008043.1	2.272e-136	53.44	SMESG000008043.1	[more]
SMESG000008043.1	6.860e-135	53.48	SMESG000008043.1	[more]
SMESG000077416.1	1.094e-53	29.54	SMESG000077416.1	[more]
SMESG000031677.1	6.792e-49	31.93	SMESG000031677.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30032475 ID=SMED30032475|Name=DUF89 domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1355bp
TTAAATTCATAAACTTTTTAAAATCCAATAATTTTATAATAATTTCAATT
AATTTCGTCTGAAATTAAAACAAATTAAAATTATCATTTAAAATTTTGTT
TTAGTATTATAAATAATAATATTTTCAGCTGGCACACGTGCGATTTGTTG
AGTTAGTCAATAGACTACACAATTGGCATATTAGTATATACATATGTATC
TGTTAGGTTTTCACATTTTTCACAAAAATGCCGCCGATTGTCGTAAAAAA
AATTTCATTTAAAAAGTGTTTTTTAAACCAAGTGGAAGTTTTGGCGAGTT
TAGATAGGGGTTGTTCTTTGACAAAAGTCATTTACTTCGACAAATCAGAT
AAAAATCTCGCTGATGAAGACCCTTCGATAGACACGGTAATATTAACATT
GGCATTGTTTGATAACAACAACTTGGACGAAGTGCTGCTGATTTTAAAAG
AAAATGCTTATTTTCCAGAAAATCAAACTTTACCTTTTCATGTAACAGGA
GCTGGAGGAGATAAATATAGTAAAAGAATAAAAGAAATCTTGGAAAGAGA
CGTAATTTTTATCGATGAATATTTGAGTCAAGCAAGAGGAACATATTTTT
TTTTAAAATATGCTTCATTGGAAGATATAATTTACGAAAATGTTGAAATA
GAGGATGTTGAACCCATAGAGGCTCCATTTGCTTCCAATATCAAAGGTCA
TTTTGATACAATTGTAACTAATAACATAACCGAGGAAGACGATGAAAAAT
TTCCATGCATTTTTGCAATAATGGGCAGCGGTGCTGGCTGTATGAGACTG
AATTCAGATGGAACGTTTCATATGGCATGTAACATGATTGACGTCGGCAA
ACCGTTCATTGGAATGTGTAGATGTATTCTTGAAACAAATAACTATGAAG
AAATAATGGATATGGCAGCGAAAGGGGACCGAAGAAATGTGGACACAACG
ACAGAAGATATAGTTGCGGCTGATAGTCCTTATGGGAAAATCCCGGGCGG
TATTTCTTTAATTCCCTTAGGCAAATTAGCTGATACTAATAAGGATATTA
GTGAATTTAATAAAAATGATATCGCTCATTCATTAGTGTCGCTATTCATT
TACAATGCAATGATCAACGCCATTCACTGCTGCATTGCCGAGAAAGTTAA
GACGGTATTCTTTGGTGGAAATTTATTCCAAAGTGAAATATTTAGAAAAG
AATACAGTTATTTGAAAAAAGTCTATACCTTGGACTTTGTGAACTTTTAT
TTTGTAAACAATGGCCATTCGGGAGCCCTTGGTGCAATGGTCAGTTGTCC
AGAAGATGTGAAGAAATATAAGAAATGAATTTCCCATTTGATTTATCAAA
ATAAA

protein sequence of SMED30032475-orf-1

>SMED30032475-orf-1 ID=SMED30032475-orf-1|Name=SMED30032475-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=367bp
MPPIVVKKISFKKCFLNQVEVLASLDRGCSLTKVIYFDKSDKNLADEDPS
IDTVILTLALFDNNNLDEVLLILKENAYFPENQTLPFHVTGAGGDKYSKR
IKEILERDVIFIDEYLSQARGTYFFLKYASLEDIIYENVEIEDVEPIEAP
FASNIKGHFDTIVTNNITEEDDEKFPCIFAIMGSGAGCMRLNSDGTFHMA
CNMIDVGKPFIGMCRCILETNNYEEIMDMAAKGDRRNVDTTTEDIVAADS
PYGKIPGGISLIPLGKLADTNKDISEFNKNDIAHSLVSLFIYNAMINAIH
CCIAEKVKTVFFGGNLFQSEIFRKEYSYLKKVYTLDFVNFYFVNNGHSGA
LGAMVSCPEDVKKYKK*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000026	gut
PLANA:0000070	intestinal phagocyte
PLANA:0002075	pigment cell
PLANA:0003116	parenchymal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR043129	ATPase_NBD
IPR004567	Type_II_PanK

Vocabulary: **biological process**
Term	Definition
GO:0015937	coenzyme A biosynthetic process
GO:0016310	phosphorylation

Vocabulary: **molecular function**
Term	Definition
GO:0004594	pantothenate kinase activity
GO:0005524	ATP binding
GO:0016301	kinase activity

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	GENE3D	G3DSA:3.30.420.510		coord: 24..354 e-value: 3.9E-31 score: 110.4
None	No IPR available	GENE3D	G3DSA:3.30.420.40		coord: 134..347 e-value: 3.9E-31 score: 110.4
None	No IPR available	GENE3D	G3DSA:1.10.8.780		coord: 235..278 e-value: 3.9E-31 score: 110.4
None	No IPR available	PANTHER	PTHR12280:SF20	PANTOTHENATE KINASE 4	coord: 24..360
None	No IPR available	PANTHER	PTHR12280	PANTOTHENATE KINASE	coord: 24..360
IPR004567	Type II pantothenate kinase	PFAM	PF03630	Fumble	coord: 24..355 e-value: 6.0E-34 score: 117.7
IPR043129	ATPase, nucleotide binding domain	SUPERFAMILY	SSF53067	Actin-like ATPase domain	coord: 105..356
IPR043129	ATPase, nucleotide binding domain	SUPERFAMILY	SSF53067	Actin-like ATPase domain	coord: 24..128

Main menu

DUF89 domain-containing protein

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 10

Owlery

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