Expressed conserved protein
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30032448 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 13
Homology
BLAST of Expressed conserved protein vs. TrEMBL
Match: A0A1I8FCJ2 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=4 SV=1) HSP 1 Score: 89.7373 bits (221), Expect = 4.619e-16 Identity = 46/100 (46.00%), Postives = 70/100 (70.00%), Query Frame = 3 Query: 936 LGNIDIELINDEGETECVDIDIADTENSKEEDKYLPNTRRQSISDRINRRRTSELAAEIIRLSAEHRKKEFADLLNEHEEIVQNIEIWKKFGVLPQTKSQ 1235 L +I++ + N++GE E V+ID+ADTE+ + R+Q I+DRI+RRR SE+AA+IIR+SA HR++EFA L++EH+ IV+ +E G PQ + Q Sbjct: 170 LSSIEMMVQNEDGEAEEVEIDVADTEDDVVARRSRKRCRKQPIADRISRRRNSEVAADIIRMSAAHRRREFAALIDEHQAIVRELE-----GQKPQQQHQ 264
BLAST of Expressed conserved protein vs. TrEMBL
Match: A0A267DZ51 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig006745g1 PE=4 SV=1) HSP 1 Score: 87.0409 bits (214), Expect = 3.003e-14 Identity = 48/106 (45.28%), Postives = 71/106 (66.98%), Query Frame = 3 Query: 936 LGNIDIELINDEGETECVDIDIADTENSKEEDKYLP------NTRRQSISDRINRRRTSELAAEIIRLSAEHRKKEFADLLNEHEEIVQNIEIWKKFGVLPQTKSQ 1235 L +I++ + N++GE E V+ID+ADTE+ D P R+Q I+DRI+RRR SE+AA+IIR+SA HR++EFA L++EH+ IV+ +E G PQ + Q Sbjct: 395 LSSIEMMVQNEDGEAEEVEIDVADTED----DVVAPLAKDNQRCRKQPIADRISRRRNSEVAADIIRMSAAHRRREFAALIDEHQAIVRELE-----GQKPQQQHQ 491
BLAST of Expressed conserved protein vs. TrEMBL
Match: A0A1I8IHD5 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=4 SV=1) HSP 1 Score: 75.0998 bits (183), Expect = 4.844e-12 Identity = 47/102 (46.08%), Postives = 70/102 (68.63%), Query Frame = 3 Query: 936 LGNIDIELINDEGETECVDIDIADTENSKEEDKYLPNTR--RQSISDRINRRRTSELAAEIIRLSAEHRKKEFADLLNEHEEIVQNIEIWKKFGVLPQTKSQ 1235 L +I++ + N++GE E V+ID+ADTE+ N R +Q I+DRI+RRR SE+AA+IIR+SA HR++EFA L++EH+ IV+ +E G PQ + Q Sbjct: 55 LSSIEMMVQNEDGEAEEVEIDVADTEDDVVAPLAKDNQRCRKQPIADRISRRRNSEVAADIIRMSAAHRRREFAALIDEHQAIVRELE-----GQKPQQQHQ 151
BLAST of Expressed conserved protein vs. TrEMBL
Match: A0A0R3WHY1 (Uncharacterized protein OS=Hydatigena taeniaeformis OX=6205 GN=TTAC_LOCUS174 PE=4 SV=1) HSP 1 Score: 74.7146 bits (182), Expect = 5.122e-12 Identity = 47/124 (37.90%), Postives = 65/124 (52.42%), Query Frame = 3 Query: 861 TLSSTSLTPSFIFKSK-PAPPRRTNTLGNIDIELINDEGETECVDIDIADTENSKEEDKYLPN----------TRRQSISDRINRRRTSELAAEIIRLSAEHRKKEFADLLNEHEEIVQNIEIW 1199 T+ S T SF S+ P P + + + IEL+N+ GE + V+ID D D L + RRQSI+DRINRRR +E A E R+ A R+KEF LL EH +V +++ W Sbjct: 4 TIPELSRTVSFGSISENPLPSQNQRSQSVVSIELLNENGEHDMVEIDEVDDVLEASADSRLGSHGASNDHEMRVRRQSIADRINRRRDTEFAFEFTRVEAAGREKEFFRLLEEHSRLVHSVQFW 127
BLAST of Expressed conserved protein vs. TrEMBL
Match: A0A0R3VSK2 (Uncharacterized protein OS=Taenia asiatica OX=60517 GN=TASK_LOCUS150 PE=4 SV=1) HSP 1 Score: 75.485 bits (184), Expect = 6.210e-12 Identity = 40/95 (42.11%), Postives = 53/95 (55.79%), Query Frame = 3 Query: 945 IDIELINDEGETECVDIDIADTENSKEEDKYL----------PNTRRQSISDRINRRRTSELAAEIIRLSAEHRKKEFADLLNEHEEIVQNIEIW 1199 + IEL+N+ GE + V+ID D D L P RRQSI+DRINRRR +E A E R+ A R+KEF LL EH +V +++ W Sbjct: 33 VSIELLNENGEYDTVEIDEVDDVLEDPVDSRLGSRGASSDREPRVRRQSIADRINRRRNTEFAFEFTRVEAAGREKEFFRLLEEHSRLVHSVQFW 127
BLAST of Expressed conserved protein vs. Planmine SMEST
Match: SMESG000064362.1 (SMESG000064362.1) HSP 1 Score: 670.618 bits (1729), Expect = 0.000e+0 Identity = 358/358 (100.00%), Postives = 358/358 (100.00%), Query Frame = 3 Query: 324 MHGLWNNIKSSVEETLETIILSPKKLRKKFAENKQNSTISEQSASSDKESQDQTKKINDNSMYKGLTSTSNPEEKSDKTNIDNITQRIPAVITNESECDRETLIERQETGYSSHXXXXXXXXXXXXXXXACQPETRLMRNADPKNSSQTDSCHLTGDHNQMEPSNVRLTSSTNFKKGGDTLSSTSLTPSFIFKSKPAPPRRTNTLGNIDIELINDEGETECVDIDIADTENSKEEDKYLPNTRRQSISDRINRRRTSELAAEIIRLSAEHRKKEFADLLNEHEEIVQNIEIWKKFGVLPQTKSQVKSTLETVXXXXXXXXXXXXPAYFRQINDNASFYLSSNRFNQDNKENKTLPRSH 1397 MHGLWNNIKSSVEETLETIILSPKKLRKKFAENKQNSTISEQSASSDKESQDQTKKINDNSMYKGLTSTSNPEEKSDKTNIDNITQRIPAVITNESECDRETLIERQETGYSSHSNGSSVGQPSISSSIACQPETRLMRNADPKNSSQTDSCHLTGDHNQMEPSNVRLTSSTNFKKGGDTLSSTSLTPSFIFKSKPAPPRRTNTLGNIDIELINDEGETECVDIDIADTENSKEEDKYLPNTRRQSISDRINRRRTSELAAEIIRLSAEHRKKEFADLLNEHEEIVQNIEIWKKFGVLPQTKSQVKSTLETVDDEDSDDIIDEEPAYFRQINDNASFYLSSNRFNQDNKENKTLPRSH Sbjct: 1 MHGLWNNIKSSVEETLETIILSPKKLRKKFAENKQNSTISEQSASSDKESQDQTKKINDNSMYKGLTSTSNPEEKSDKTNIDNITQRIPAVITNESECDRETLIERQETGYSSHSNGSSVGQPSISSSIACQPETRLMRNADPKNSSQTDSCHLTGDHNQMEPSNVRLTSSTNFKKGGDTLSSTSLTPSFIFKSKPAPPRRTNTLGNIDIELINDEGETECVDIDIADTENSKEEDKYLPNTRRQSISDRINRRRTSELAAEIIRLSAEHRKKEFADLLNEHEEIVQNIEIWKKFGVLPQTKSQVKSTLETVDDEDSDDIIDEEPAYFRQINDNASFYLSSNRFNQDNKENKTLPRSH 358
BLAST of Expressed conserved protein vs. Planmine SMEST
Match: SMESG000064362.1 (SMESG000064362.1) HSP 1 Score: 541.191 bits (1393), Expect = 0.000e+0 Identity = 295/298 (98.99%), Postives = 296/298 (99.33%), Query Frame = 3 Query: 507 MY-KGLTSTSNPEEKSDKTNIDNITQRIPAVITNESECDRETLIERQETGYSSHXXXXXXXXXXXXXXXACQPETRLMRNADPKNSSQTDSCHLTGDHNQMEPSNVRLTSSTNFKKGGDTLSSTSLTPSFIFKSKPAPPRRTNTLGNIDIELINDEGETECVDIDIADTENSKEEDKYLPNTRRQSISDRINRRRTSELAAEIIRLSAEHRKKEFADLLNEHEEIVQNIEIWKKFGVLPQTKSQVKSTLETVXXXXXXXXXXXXPAYFRQINDNASFYLSSNRFNQDNKENKTLPRSH 1397 MY + LTSTSNPEEKSDKTNIDNITQRIPAVITNESECDRETLIERQETGYSSHSNGSSVGQPSISSSIACQPETRLMRNADPKNSSQTDSCHLTGDHNQMEPSNVRLTSSTNFKKGGDTLSSTSLTPSFIFKSKPAPPRRTNTLGNIDIELINDEGETECVDIDIADTENSKEEDKYLPNTRRQSISDRINRRRTSELAAEIIRLSAEHRKKEFADLLNEHEEIVQNIEIWKKFGVLPQTKSQVKSTLETVDDEDSDDIIDEEPAYFRQINDNASFYLSSNRFNQDNKENKTLPRSH Sbjct: 1 MYNRWLTSTSNPEEKSDKTNIDNITQRIPAVITNESECDRETLIERQETGYSSHSNGSSVGQPSISSSIACQPETRLMRNADPKNSSQTDSCHLTGDHNQMEPSNVRLTSSTNFKKGGDTLSSTSLTPSFIFKSKPAPPRRTNTLGNIDIELINDEGETECVDIDIADTENSKEEDKYLPNTRRQSISDRINRRRTSELAAEIIRLSAEHRKKEFADLLNEHEEIVQNIEIWKKFGVLPQTKSQVKSTLETVDDEDSDDIIDEEPAYFRQINDNASFYLSSNRFNQDNKENKTLPRSH 298 The following BLAST results are available for this feature:
BLAST of Expressed conserved protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of Expressed conserved protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of Expressed conserved protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of Expressed conserved protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of Expressed conserved protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of Expressed conserved protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of Expressed conserved protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 0
BLAST of Expressed conserved protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Expressed conserved protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of Expressed conserved protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of Expressed conserved protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Expressed conserved protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of Expressed conserved protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of Expressed conserved protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 2
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30032448 ID=SMED30032448|Name=Expressed conserved protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1861bpback to top protein sequence of SMED30032448-orf-1 >SMED30032448-orf-1 ID=SMED30032448-orf-1|Name=SMED30032448-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=359bp MHGLWNNIKSSVEETLETIILSPKKLRKKFAENKQNSTISEQSASSDKESback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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