Protein kinase domain-containing protein
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30032093 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 20
Homology
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855]) HSP 1 Score: 121.709 bits (304), Expect = 8.320e-28 Identity = 87/278 (31.29%), Postives = 140/278 (50.36%), Query Frame = 1
Query: 1441 NFDLGKEIARGGFGIVFHCQEKISGKNVILKKL--------IDKKLTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINP-----ISKELNELINLCLTVNPDERPTGEELMKSEFFK 2235
N+ GK + +G FG V+ C + +G+ + K++ K++++ +I + +L Q E +V + ++D + ++ + M YM GGS ++ LK + L E K + QIL ++ LH ++H DIK NI+ D GN K D+G +K RL+ S S GT Y+++PEVI GE Y K D+WS G +VEM+T KPP WA + + K +P NP IS+ + + V +RP+ EEL+ F +
Sbjct: 361 NWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNL-QHERIVQYYGCLRDRAEKTLTIFMEYMPGGS----VKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASK---RLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPP--WAEYE----AMAAIFKIATQPTNPQLPSHISEHGRDFLRRIF-VEARQRPSAEELLTHHFAQ 623
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855]) HSP 1 Score: 121.709 bits (304), Expect = 9.196e-28 Identity = 87/278 (31.29%), Postives = 140/278 (50.36%), Query Frame = 1
Query: 1441 NFDLGKEIARGGFGIVFHCQEKISGKNVILKKL--------IDKKLTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINP-----ISKELNELINLCLTVNPDERPTGEELMKSEFFK 2235
N+ GK + +G FG V+ C + +G+ + K++ K++++ +I + +L Q E +V + ++D + ++ + M YM GGS ++ LK + L E K + QIL ++ LH ++H DIK NI+ D GN K D+G +K RL+ S S GT Y+++PEVI GE Y K D+WS G +VEM+T KPP WA + + K +P NP IS+ + + V +RP+ EEL+ F +
Sbjct: 357 NWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNL-QHERIVQYYGCLRDRAEKTLTIFMEYMPGGS----VKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASK---RLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPP--WAEYE----AMAAIFKIATQPTNPQLPSHISEHGRDFLRRIF-VEARQRPSAEELLTHHFAQ 619
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855]) HSP 1 Score: 121.709 bits (304), Expect = 1.102e-27 Identity = 87/278 (31.29%), Postives = 140/278 (50.36%), Query Frame = 1
Query: 1441 NFDLGKEIARGGFGIVFHCQEKISGKNVILKKL--------IDKKLTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINP-----ISKELNELINLCLTVNPDERPTGEELMKSEFFK 2235
N+ GK + +G FG V+ C + +G+ + K++ K++++ +I + +L Q E +V + ++D + ++ + M YM GGS ++ LK + L E K + QIL ++ LH ++H DIK NI+ D GN K D+G +K RL+ S S GT Y+++PEVI GE Y K D+WS G +VEM+T KPP WA + + K +P NP IS+ + + V +RP+ EEL+ F +
Sbjct: 388 NWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNL-QHERIVQYYGCLRDRAEKTLTIFMEYMPGGS----VKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASK---RLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPP--WAEYE----AMAAIFKIATQPTNPQLPSHISEHGRDFLRRIF-VEARQRPSAEELLTHHFAQ 650
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855]) HSP 1 Score: 121.324 bits (303), Expect = 1.401e-27 Identity = 87/278 (31.29%), Postives = 140/278 (50.36%), Query Frame = 1
Query: 1441 NFDLGKEIARGGFGIVFHCQEKISGKNVILKKL--------IDKKLTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINP-----ISKELNELINLCLTVNPDERPTGEELMKSEFFK 2235
N+ GK + +G FG V+ C + +G+ + K++ K++++ +I + +L Q E +V + ++D + ++ + M YM GGS ++ LK + L E K + QIL ++ LH ++H DIK NI+ D GN K D+G +K RL+ S S GT Y+++PEVI GE Y K D+WS G +VEM+T KPP WA + + K +P NP IS+ + + V +RP+ EEL+ F +
Sbjct: 392 NWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNL-QHERIVQYYGCLRDRAEKTLTIFMEYMPGGS----VKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASK---RLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPP--WAEYE----AMAAIFKIATQPTNPQLPSHISEHGRDFLRRIF-VEARQRPSAEELLTHHFAQ 654
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855]) HSP 1 Score: 121.324 bits (303), Expect = 1.401e-27 Identity = 87/278 (31.29%), Postives = 140/278 (50.36%), Query Frame = 1
Query: 1441 NFDLGKEIARGGFGIVFHCQEKISGKNVILKKL--------IDKKLTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINP-----ISKELNELINLCLTVNPDERPTGEELMKSEFFK 2235
N+ GK + +G FG V+ C + +G+ + K++ K++++ +I + +L Q E +V + ++D + ++ + M YM GGS ++ LK + L E K + QIL ++ LH ++H DIK NI+ D GN K D+G +K RL+ S S GT Y+++PEVI GE Y K D+WS G +VEM+T KPP WA + + K +P NP IS+ + + V +RP+ EEL+ F +
Sbjct: 392 NWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNL-QHERIVQYYGCLRDRAEKTLTIFMEYMPGGS----VKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASK---RLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPP--WAEYE----AMAAIFKIATQPTNPQLPSHISEHGRDFLRRIF-VEARQRPSAEELLTHHFAQ 654
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: pak-2 (Serine/threonine-protein kinase pak-2 [Source:UniProtKB/Swiss-Prot;Acc:G5EFU0]) HSP 1 Score: 114.005 bits (284), Expect = 4.491e-26 Identity = 84/274 (30.66%), Postives = 136/274 (49.64%), Query Frame = 1
Query: 1456 KEIARGGFGIVFHCQEKISGKNVILKKLID----KKLTSFYRDIFISYHLNQAEH--LVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPF----HWAGIGRVSLELTKMKKYKFKPINPISKELNELINLCLTVNPDERPTGEELMKSEFFKDCLH 2247
K+I G G+V KIS K ++ K ++ ++ + ++ I L Q +H +V F D + + M +M GGSLT + + E I IS Q+L ++ LH KVIH DIK D+I+ +G K D+G + ++ R+ S GT Y+ A EVI E Y + DIWSFG++L+EMV G+PPF + + R+ E + +F +S EL+EL++ C+ + ++R ++L++ FF H
Sbjct: 233 KQIGEGSTGVV-EAAYKISTKQIVAVKRMNLRKQQRRELLFNEVSI---LRQYQHPNIVRFFS--SHLVDDELWVVMEFMEGGSLTDIVTATR-----MTEPQIATISRQVLGALDFLHARKVIHRDIKSDSILLKRDGTVKLTDFGFCGQL------SEEVPRRRSLVGTPYWTAAEVIAREPYDTRADIWSFGIMLIEMVEGEPPFFNDQPFQAMKRIRDE----HEARFSRHAKVSVELSELLSHCIVKDVNKRWPAKDLLRHPFFAKAQH 485
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: pak-2 (Serine/threonine-protein kinase pak-2 [Source:UniProtKB/Swiss-Prot;Acc:G5EFU0]) HSP 1 Score: 114.005 bits (284), Expect = 4.823e-26 Identity = 82/270 (30.37%), Postives = 133/270 (49.26%), Query Frame = 1
Query: 1456 KEIARGGFGIVFHCQEKISGKNVILKKLID----KKLTSFYRDIFISYHLNQAEH--LVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINPISKELNELINLCLTVNPDERPTGEELMKSEFFKDCLH 2247
K+I G G+V KIS K ++ K ++ ++ + ++ I L Q +H +V F D + + M +M GGSLT + + E I IS Q+L ++ LH KVIH DIK D+I+ +G K D+G + ++ R+ S GT Y+ A EVI E Y + DIWSFG++L+EMV G+PPF + + + +F +S EL+EL++ C+ + ++R ++L++ FF H
Sbjct: 235 KQIGEGSTGVV-EAAYKISTKQIVAVKRMNLRKQQRRELLFNEVSI---LRQYQHPNIVRFFS--SHLVDDELWVVMEFMEGGSLTDIVTATR-----MTEPQIATISRQVLGALDFLHARKVIHRDIKSDSILLKRDGTVKLTDFGFCGQL------SEEVPRRRSLVGTPYWTAAEVIAREPYDTRADIWSFGIMLIEMVEGEPPFFNDQPFQAMKRIRDEHEARFSRHAKVSVELSELLSHCIVKDVNKRWPAKDLLRHPFFAKAQH 487
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: max-2 (Serine/threonine-protein kinase max-2 [Source:UniProtKB/Swiss-Prot;Acc:G5EGQ3]) HSP 1 Score: 107.842 bits (268), Expect = 1.265e-25 Identity = 75/269 (27.88%), Postives = 131/269 (48.70%), Query Frame = 1
Query: 1450 LGKEIARGGFGIVFHCQEKISGKNVILKKLIDKKLTSFYRDIFIS--YHLNQAEH--LVNGFE-IVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINPISKELNELINLCLTVNPDERPTGEELMKSEFFKDC 2241
+ K+I G G VF S V +K++ K T +++ ++ + Q H LVN E + D +D + + M Y+ GG+LT + + L E I + + L ++ LH ++H DIK DN++ G K D G + Q ++++ GT Y+++PE++ + Y+YK DIWS G++ +EM+ G+PP+ + + + K + K + +S E N ++ CL V+PD+R EL+ F K
Sbjct: 1 MKKQIGVGASGTVFVANVAGSTDVVAVKRMAFK--TQPKKEMLLTEIKVMKQYRHPNLVNYIESYLVDADD--LWVVMDYLEGGNLTDVVVKT-----ELDEGQIAAVLQECLKALHFLHRHSIVHRDIKSDNVLLGMNGEVKLTDMGFCAQI-------QPGSKRDTVVGTPYWMSPEILNKKQYNYKVDIWSLGIMALEMIDGEPPYLRETPLKAIYLIAQNGKPEIKQRDRLSSEFNNFLDKCLVVDPDQRADTTELLAHPFLKKA 253
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: max-2 (Serine/threonine-protein kinase max-2 [Source:UniProtKB/Swiss-Prot;Acc:G5EGQ3]) HSP 1 Score: 110.923 bits (276), Expect = 1.760e-25 Identity = 76/274 (27.74%), Postives = 134/274 (48.91%), Query Frame = 1
Query: 1435 LENFDLGKEIARGGFGIVFHCQEKISGKNVILKKLIDKKLTSFYRDIFIS--YHLNQAEH--LVNGFE-IVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINPISKELNELINLCLTVNPDERPTGEELMKSEFFKDC 2241
L +++ K+I G G VF S V +K++ K T +++ ++ + Q H LVN E + D +D + + M Y+ GG+LT + + L E I + + L ++ LH ++H DIK DN++ G K D G + Q ++++ GT Y+++PE++ + Y+YK DIWS G++ +EM+ G+PP+ + + + K + K + +S E N ++ CL V+PD+R EL+ F K
Sbjct: 153 LGKYEMKKQIGVGASGTVFVANVAGSTDVVAVKRMAFK--TQPKKEMLLTEIKVMKQYRHPNLVNYIESYLVDADD--LWVVMDYLEGGNLTDVVVKT-----ELDEGQIAAVLQECLKALHFLHRHSIVHRDIKSDNVLLGMNGEVKLTDMGFCAQI-------QPGSKRDTVVGTPYWMSPEILNKKQYNYKVDIWSLGIMALEMIDGEPPYLRETPLKAIYLIAQNGKPEIKQRDRLSSEFNNFLDKCLVVDPDQRADTTELLAHPFLKKA 410
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: max-2 (Serine/threonine-protein kinase max-2 [Source:UniProtKB/Swiss-Prot;Acc:G5EGQ3]) HSP 1 Score: 108.612 bits (270), Expect = 5.225e-24 Identity = 76/274 (27.74%), Postives = 134/274 (48.91%), Query Frame = 1
Query: 1435 LENFDLGKEIARGGFGIVFHCQEKISGKNVILKKLIDKKLTSFYRDIFIS--YHLNQAEH--LVNGFE-IVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINPISKELNELINLCLTVNPDERPTGEELMKSEFFKDC 2241
L +++ K+I G G VF S V +K++ K T +++ ++ + Q H LVN E + D +D + + M Y+ GG+LT + + L E I + + L ++ LH ++H DIK DN++ G K D G + Q ++++ GT Y+++PE++ + Y+YK DIWS G++ +EM+ G+PP+ + + + K + K + +S E N ++ CL V+PD+R EL+ F K
Sbjct: 328 LGKYEMKKQIGVGASGTVFVANVAGSTDVVAVKRMAFK--TQPKKEMLLTEIKVMKQYRHPNLVNYIESYLVDADD--LWVVMDYLEGGNLTDVVVKT-----ELDEGQIAAVLQECLKALHFLHRHSIVHRDIKSDNVLLGMNGEVKLTDMGFCAQI-------QPGSKRDTVVGTPYWMSPEILNKKQYNYKVDIWSLGIMALEMIDGEPPYLRETPLKAIYLIAQNGKPEIKQRDRLSSEFNNFLDKCLVVDPDQRADTTELLAHPFLKKA 585
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: Pak3 (gene:FBgn0044826 transcript:FBtr0330047) HSP 1 Score: 122.865 bits (307), Expect = 1.560e-28 Identity = 77/272 (28.31%), Postives = 135/272 (49.63%), Query Frame = 1
Query: 1438 ENFDLGKEIARGGFGIVFHCQEKISGKNVILKKLIDKKLTS----FYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINPISKELNELINLCLTVNPDERPTGEELMKSEFFKDC 2241
E + +E+ +G GIVF + + ++ + K ID K S +I + N ++LVN + + + + M YM GG LT + + + ++E+ I + + L I+ LH +IH DIK DN++ +G+ K D+G ++E E ++++ GT Y++APEV+ + Y K DIWS G++ +EM+ G+PP+ + R + + K + +S L + ++ CL V D R T +EL+ F DC
Sbjct: 291 ERYKTTQEVGKGASGIVFIAAD-LQNESQVAVKTIDMKNQSSKDLILTEIRVLKDFNH-KNLVNFLDAYLLEPEDQLWVVMEYMDGGPLTDVVTETV-----MKERQIACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCANIEGDE-------KRQTMVGTPYWMAPEVVTRKKYGKKVDIWSIGIMAIEMIEGQPPYLYETPLRALYLIAANGRPDIKSWDKLSPNLQDFLDRCLQVEVDRRATADELLSHPFLNDC 548
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: Pak3 (gene:FBgn0044826 transcript:FBtr0083312) HSP 1 Score: 122.479 bits (306), Expect = 1.643e-28 Identity = 77/272 (28.31%), Postives = 135/272 (49.63%), Query Frame = 1
Query: 1438 ENFDLGKEIARGGFGIVFHCQEKISGKNVILKKLIDKKLTS----FYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINPISKELNELINLCLTVNPDERPTGEELMKSEFFKDC 2241
E + +E+ +G GIVF + + ++ + K ID K S +I + N ++LVN + + + + M YM GG LT + + + ++E+ I + + L I+ LH +IH DIK DN++ +G+ K D+G ++E E ++++ GT Y++APEV+ + Y K DIWS G++ +EM+ G+PP+ + R + + K + +S L + ++ CL V D R T +EL+ F DC
Sbjct: 291 ERYKTTQEVGKGASGIVFIAAD-LQNESQVAVKTIDMKNQSSKDLILTEIRVLKDFNH-KNLVNFLDAYLLEPEDQLWVVMEYMDGGPLTDVVTETV-----MKERQIACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCANIEGDE-------KRQTMVGTPYWMAPEVVTRKKYGKKVDIWSIGIMAIEMIEGQPPYLYETPLRALYLIAANGRPDIKSWDKLSPNLQDFLDRCLQVEVDRRATADELLSHPFLNDC 548
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: Pak3 (gene:FBgn0044826 transcript:FBtr0305003) HSP 1 Score: 122.479 bits (306), Expect = 1.643e-28 Identity = 77/272 (28.31%), Postives = 135/272 (49.63%), Query Frame = 1
Query: 1438 ENFDLGKEIARGGFGIVFHCQEKISGKNVILKKLIDKKLTS----FYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINPISKELNELINLCLTVNPDERPTGEELMKSEFFKDC 2241
E + +E+ +G GIVF + + ++ + K ID K S +I + N ++LVN + + + + M YM GG LT + + + ++E+ I + + L I+ LH +IH DIK DN++ +G+ K D+G ++E E ++++ GT Y++APEV+ + Y K DIWS G++ +EM+ G+PP+ + R + + K + +S L + ++ CL V D R T +EL+ F DC
Sbjct: 291 ERYKTTQEVGKGASGIVFIAAD-LQNESQVAVKTIDMKNQSSKDLILTEIRVLKDFNH-KNLVNFLDAYLLEPEDQLWVVMEYMDGGPLTDVVTETV-----MKERQIACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCANIEGDE-------KRQTMVGTPYWMAPEVVTRKKYGKKVDIWSIGIMAIEMIEGQPPYLYETPLRALYLIAANGRPDIKSWDKLSPNLQDFLDRCLQVEVDRRATADELLSHPFLNDC 548
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: Nek2 (gene:FBgn0029970 transcript:FBtr0071142) HSP 1 Score: 110.538 bits (275), Expect = 2.283e-24 Identity = 76/284 (26.76%), Postives = 146/284 (51.41%), Query Frame = 1
Query: 1399 QGGGILFEKMKRLENFDLGKEIARGGFGIVFHCQEKISG-----KNVILKKLIDKKLTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQI----NELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINPI-SKELNELINLCLTVNPDERPTGEELMK 2220
+ G+ F + K L+++++ + G FG + ++K +G K + +L + K + +I + L Q ++V + + + S+ + M +GG L +++ Q + +E +I ++ +Q+ + N++ ++H DIKP NI D GNAK D+GLA+ + R + A S GT +Y++PE++KG Y K+D+W+ G ++ EM +PPF ++S K+ + +F I I S +L E+I L V+ ++RP E +++
Sbjct: 5 ESAGMDFSQ-KTLQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEISVLRQL-QHPNIVQYYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQRFEEPYIWRVLFQLCRALQVCHNKIPNGTILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFA------ASFVGTPHYMSPELVKGRKYDRKSDVWAVGCLVYEMCALRPPFRGRAFDQLS---EKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPGIEVIIR 277
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: mbt (gene:FBgn0025743 transcript:FBtr0074285) HSP 1 Score: 109.383 bits (272), Expect = 4.280e-24 Identity = 78/278 (28.06%), Postives = 128/278 (46.04%), Query Frame = 1
Query: 1438 ENFDLGKEIARGGFGIVFHCQEKISGKNVILKKLIDKKLTS---FYRDIFIS---YHLNQAEHLVNGFEIVQDYNDGSIN----LAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINPISKELNELINLCLTVNPDERPTGEELMKSEFFKDC 2241
EN D +I G G V +K +G+ V +KK+ +K + ++ I +H N IV+ Y+ +N + M Y+ GG+LT + + E+ I + Q L + LH VIH DIK D+I+ +G K D+G V +Q +++S GT Y+++PEVI Y + DIWS G++++EMV G+PPF + + M+ K + +S L ++ L +P +R T EL+ F +
Sbjct: 366 ENLDHFNKIGEGSTGTVCIATDKSTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYHHPN----------IVETYSSFLVNDELWVVMEYLEGGALTDIVTHSR-----MDEEQIATVCKQCLKALAYLHSQGVIHRDIKSDSILLAADGRVKLSDFGFCAQV------SQELPKRKSLVGTPYWMSPEVISRLPYGPEVDIWSLGIMVIEMVDGEPPFFNEPPLQAMRRIRDMQPPNLKNAHKVSPRLQSFLDRMLVRDPAQRATAAELLAHPFLRQA 622
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:ZFIN;Acc:ZDB-GENE-070910-1]) HSP 1 Score: 129.028 bits (323), Expect = 2.645e-30 Identity = 87/272 (31.99%), Postives = 141/272 (51.84%), Query Frame = 1
Query: 1453 GKEIARGGFGIVFHCQEKISGKNVILKKL--------IDKKLTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINP-----ISKELNELINLCLTVNPDERPTGEELMKSEF 2229
GK + +G FG V+ C + +G+ + K++ K++++ +I + +L+ E +V + ++D+N+ ++ + M YM GGS ++ LK + L E K + QIL ++ LH ++H DIK NI+ D GN K D+G +K RL+ S S GT Y+++PEVI GE Y K D+WS G +VEM+T KPP WA + + K +P NP IS+ + + C+ V RP+ EEL++ F
Sbjct: 347 GKLLGQGAFGRVYLCYDVDTGRELAAKQVHFDPASPETSKEVSALECEIQLLKNLHH-ERIVQYYGCLRDHNEKTLTIFMEYMPGGS----VKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASK---RLQTICMSSTGVRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPP--WAEFE----AMAAIFKIATQPTNPQLPSHISEHTRDFLR-CIFVEAKYRPSAEELLRHPF 603
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:ZFIN;Acc:ZDB-GENE-070910-1]) HSP 1 Score: 128.642 bits (322), Expect = 3.567e-30 Identity = 87/272 (31.99%), Postives = 141/272 (51.84%), Query Frame = 1
Query: 1453 GKEIARGGFGIVFHCQEKISGKNVILKKL--------IDKKLTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINP-----ISKELNELINLCLTVNPDERPTGEELMKSEF 2229
GK + +G FG V+ C + +G+ + K++ K++++ +I + +L+ E +V + ++D+N+ ++ + M YM GGS ++ LK + L E K + QIL ++ LH ++H DIK NI+ D GN K D+G +K RL+ S S GT Y+++PEVI GE Y K D+WS G +VEM+T KPP WA + + K +P NP IS+ + + C+ V RP+ EEL++ F
Sbjct: 365 GKLLGQGAFGRVYLCYDVDTGRELAAKQVHFDPASPETSKEVSALECEIQLLKNLHH-ERIVQYYGCLRDHNEKTLTIFMEYMPGGS----VKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASK---RLQTICMSSTGVRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPP--WAEFE----AMAAIFKIATQPTNPQLPSHISEHTRDFLR-CIFVEAKYRPSAEELLRHPF 621
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:ZFIN;Acc:ZDB-GENE-070910-1]) HSP 1 Score: 128.257 bits (321), Expect = 4.591e-30 Identity = 87/272 (31.99%), Postives = 141/272 (51.84%), Query Frame = 1
Query: 1453 GKEIARGGFGIVFHCQEKISGKNVILKKL--------IDKKLTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINP-----ISKELNELINLCLTVNPDERPTGEELMKSEF 2229
GK + +G FG V+ C + +G+ + K++ K++++ +I + +L+ E +V + ++D+N+ ++ + M YM GGS ++ LK + L E K + QIL ++ LH ++H DIK NI+ D GN K D+G +K RL+ S S GT Y+++PEVI GE Y K D+WS G +VEM+T KPP WA + + K +P NP IS+ + + C+ V RP+ EEL++ F
Sbjct: 359 GKLLGQGAFGRVYLCYDVDTGRELAAKQVHFDPASPETSKEVSALECEIQLLKNLHH-ERIVQYYGCLRDHNEKTLTIFMEYMPGGS----VKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASK---RLQTICMSSTGVRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPP--WAEFE----AMAAIFKIATQPTNPQLPSHISEHTRDFLR-CIFVEAKYRPSAEELLRHPF 615
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:ZFIN;Acc:ZDB-GENE-120215-96]) HSP 1 Score: 120.939 bits (302), Expect = 1.110e-27 Identity = 86/276 (31.16%), Postives = 141/276 (51.09%), Query Frame = 1
Query: 1441 NFDLGKEIARGGFGIVFHCQEKISGKNVILKKL--------IDKKLTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINP-----ISKELNELINLCLTVNPDERPTGEELMKSEF 2229
N+ LGK + +G FG VF C + +G+ + +K++ K++++ +I + +L E +V + ++D ++ ++++ M YM GGS I+ LK + L E K + QIL + LH ++H DIK NI+ D GN K D+G ++ RL+ S +S GT Y+++PEVI GE Y K DIWS G +VEM+T +PP WA + + K +P NP +S + + V +RP E+L++ F
Sbjct: 353 NWRLGKLLGQGAFGRVFLCYDADTGRELAVKQVQFDPDSPETSKEVSALECEIQLLKNLFH-ERIVQYYGCLRDTHEKTLSIFMEYMPGGS----IKDQLKSYGALTENVTRKYTRQILEGVCYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASR---RLQTICLSGTGIKSVTGTPYWMSPEVISGEGYGRKADIWSIGCTVVEMLTQRPP--WAEFE----AMAAIFKIATQPTNPTLPPHVSDHCRDFLKRIF-VETKQRPAAEDLLRHTF 613
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:ZFIN;Acc:ZDB-GENE-120215-96]) HSP 1 Score: 120.553 bits (301), Expect = 1.440e-27 Identity = 86/276 (31.16%), Postives = 141/276 (51.09%), Query Frame = 1
Query: 1441 NFDLGKEIARGGFGIVFHCQEKISGKNVILKKL--------IDKKLTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINP-----ISKELNELINLCLTVNPDERPTGEELMKSEF 2229
N+ LGK + +G FG VF C + +G+ + +K++ K++++ +I + +L E +V + ++D ++ ++++ M YM GGS I+ LK + L E K + QIL + LH ++H DIK NI+ D GN K D+G ++ RL+ S +S GT Y+++PEVI GE Y K DIWS G +VEM+T +PP WA + + K +P NP +S + + V +RP E+L++ F
Sbjct: 361 NWRLGKLLGQGAFGRVFLCYDADTGRELAVKQVQFDPDSPETSKEVSALECEIQLLKNLFH-ERIVQYYGCLRDTHEKTLSIFMEYMPGGS----IKDQLKSYGALTENVTRKYTRQILEGVCYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASR---RLQTICLSGTGIKSVTGTPYWMSPEVISGEGYGRKADIWSIGCTVVEMLTQRPP--WAEFE----AMAAIFKIATQPTNPTLPPHVSDHCRDFLKRIF-VETKQRPAAEDLLRHTF 621
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: samd8 (sterile alpha motif domain containing 8 [Source:Xenbase;Acc:XB-GENE-1012742]) HSP 1 Score: 122.479 bits (306), Expect = 4.473e-28 Identity = 85/276 (30.80%), Postives = 141/276 (51.09%), Query Frame = 1
Query: 1441 NFDLGKEIARGGFGIVFHCQEKISGKNVILKKL--------IDKKLTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINP-----ISKELNELINLCLTVNPDERPTGEELMKSEF 2229
N+ GK + +G FG V+ C + +G+ + K++ K++++ +I + +L+ + +V + ++D + ++ + M YM GGS ++ LK + L E + + QIL ++ LH ++H DIK NI+ D GN K D+G +K RL+ S S GT Y+++PEVI GE Y K D+WS G +VEM+T KPP WA + + K +P NP S++ + + L V +RPT EEL++ F
Sbjct: 364 NWRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVQFDPDSPETSKEVSALECEIQLLKNLHH-DRIVQYYGSLRDKGEKTLTIFMEYMPGGS----VKDQLKAYGALTENVTRRYTRQILEGVSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASK---RLQTICMSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPP--WAEYE----AMAAIFKIATQPTNPQLPPNTSEQCRDFVKRIL-VEARQRPTAEELIRHPF 624
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: samd8 (sterile alpha motif domain containing 8 [Source:Xenbase;Acc:XB-GENE-1012742]) HSP 1 Score: 122.094 bits (305), Expect = 5.175e-28 Identity = 85/276 (30.80%), Postives = 141/276 (51.09%), Query Frame = 1
Query: 1441 NFDLGKEIARGGFGIVFHCQEKISGKNVILKKL--------IDKKLTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINP-----ISKELNELINLCLTVNPDERPTGEELMKSEF 2229
N+ GK + +G FG V+ C + +G+ + K++ K++++ +I + +L+ + +V + ++D + ++ + M YM GGS ++ LK + L E + + QIL ++ LH ++H DIK NI+ D GN K D+G +K RL+ S S GT Y+++PEVI GE Y K D+WS G +VEM+T KPP WA + + K +P NP S++ + + L V +RPT EEL++ F
Sbjct: 346 NWRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVQFDPDSPETSKEVSALECEIQLLKNLHH-DRIVQYYGSLRDKGEKTLTIFMEYMPGGS----VKDQLKAYGALTENVTRRYTRQILEGVSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASK---RLQTICMSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPP--WAEYE----AMAAIFKIATQPTNPQLPPNTSEQCRDFVKRIL-VEARQRPTAEELIRHPF 606
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: MAP3K2 (mitogen-activated protein kinase kinase kinase 2 [Source:NCBI gene;Acc:100493570]) HSP 1 Score: 121.324 bits (303), Expect = 1.039e-27 Identity = 88/276 (31.88%), Postives = 141/276 (51.09%), Query Frame = 1
Query: 1441 NFDLGKEIARGGFGIVFHCQEKISGKNVILKKL--------IDKKLTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINP-----ISKELNELINLCLTVNPDERPTGEELMKSEF 2229
N+ LGK + +G FG V+ C + +G+ + +K++ K++ + +I + +L E +V + ++D + ++++ M YM GGS I+ LK + L E K + QIL ++ LH ++H DIK NI+ D GN K D+G +K RL+ S +S GT Y+++PEVI GE Y K DIWS G +VEM+T KPP WA + + K +P NP +S+ + + V RP+ EEL++ F
Sbjct: 338 NWRLGKLLGQGAFGRVYLCYDADTGRELAVKQVQFDPDSLETSKEVNALECEIQLLKNLLH-ERIVQYYGCLRDSQEKTLSIFMEYMPGGS----IKDQLKAYGALTEFVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASK---RLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVGCTVVEMLTEKPP--WAEFE----AMAAIFKIATQPTNPQLPAHVSEHCRDFLKRIF-VEAKVRPSSEELLRHTF 598
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: MAP3K2 (mitogen-activated protein kinase kinase kinase 2 [Source:NCBI gene;Acc:100493570]) HSP 1 Score: 121.324 bits (303), Expect = 1.234e-27 Identity = 88/276 (31.88%), Postives = 141/276 (51.09%), Query Frame = 1
Query: 1441 NFDLGKEIARGGFGIVFHCQEKISGKNVILKKL--------IDKKLTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINP-----ISKELNELINLCLTVNPDERPTGEELMKSEF 2229
N+ LGK + +G FG V+ C + +G+ + +K++ K++ + +I + +L E +V + ++D + ++++ M YM GGS I+ LK + L E K + QIL ++ LH ++H DIK NI+ D GN K D+G +K RL+ S +S GT Y+++PEVI GE Y K DIWS G +VEM+T KPP WA + + K +P NP +S+ + + V RP+ EEL++ F
Sbjct: 366 NWRLGKLLGQGAFGRVYLCYDADTGRELAVKQVQFDPDSLETSKEVNALECEIQLLKNLLH-ERIVQYYGCLRDSQEKTLSIFMEYMPGGS----IKDQLKAYGALTEFVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASK---RLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVGCTVVEMLTEKPP--WAEFE----AMAAIFKIATQPTNPQLPAHVSEHCRDFLKRIF-VEAKVRPSSEELLRHTF 626
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: dennd1a (DENN domain containing 1A [Source:Xenbase;Acc:XB-GENE-5729862]) HSP 1 Score: 117.472 bits (293), Expect = 1.681e-26 Identity = 83/276 (30.07%), Postives = 141/276 (51.09%), Query Frame = 1
Query: 1438 ENFDLGKEIARGGFGIVFHCQEKISGKNVILKKL--------IDKKLTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFH----WAGIGRVSLELTKMKKYKFKPINPISKELNELINLCLTVNPDERPTGEELMKSEF 2229
EN+ LGK + RG FG V+ C + G+ + +K++ K++ + +I + L++ E +V + ++D + +++ + YM GGS I+ LK + L E + + QIL ++ LH ++H DIK NI+ D GN K D+G +K ++ + S +S GT Y+++PEVI GE Y K D+WS +VEM+T KPP+ A I +++ + TK + + +S + + V RPT EEL++ F
Sbjct: 352 ENWRLGKLLGRGAFGEVYLCYDVDKGRELAVKQVPFDPDSQETSKEVNALECEIQL-LKLHRHERIVQYYGCLRDPTERKLSIFVEYMPGGS----IKDQLKAYGALTENVTRRYTRQILQGVSYLHGNMIVHRDIKGANILRDSAGNVKLGDFGASKRIQTI---CMSGTGIKSVTGTPYWMSPEVISGEGYGRKADVWSVACTVVEMLTEKPPWSEYEAMAAIFKIATQPTKPRL-----PDTVSDACRDFMKQIF-VEEKRRPTAEELLRHLF 613
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:MGI Symbol;Acc:MGI:1346874]) HSP 1 Score: 119.013 bits (297), Expect = 4.527e-27 Identity = 87/278 (31.29%), Postives = 139/278 (50.00%), Query Frame = 1
Query: 1441 NFDLGKEIARGGFGIVFHCQEKISGKNVILKKL--------IDKKLTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINP-----ISKELNELINLCLTVNPDERPTGEELMKSEFFK 2235
N+ GK + +G FG V+ C + +G+ + K++ K++++ +I + +L Q E +V + ++D + + + M YM GGS ++ LK + L E K + QIL ++ LH ++H DIK NI+ D GN K D+G +K RL+ S S GT Y+++PEVI GE Y K D+WS G +VEM+T KPP WA + + K +P NP IS+ + + V +RP+ EEL+ F +
Sbjct: 361 NWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNL-QHERIVQYYGCLRDRAEKILTIFMEYMPGGS----VKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASK---RLQTICMSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPP--WAEYE----AMAAIFKIATQPTNPQLPSHISEHGRDFLRRIF-VEARQRPSAEELLTHHFAQ 623
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Nek7 (NIMA (never in mitosis gene a)-related expressed kinase 7 [Source:MGI Symbol;Acc:MGI:1890645]) HSP 1 Score: 111.309 bits (277), Expect = 3.618e-26 Identity = 77/263 (29.28%), Postives = 130/263 (49.43%), Query Frame = 1
Query: 1435 LENFDLGKEIARGGFGIVFHCQEKISGKNVILKK-----LIDKKLTS-FYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPI--NPISKELNELINLCLTVNPDERP 2199
L NF + K+I RG F V+ + G V LKK L+D K + ++I + LN + ++D +N+ + G L+ I+ KQ + + E+ + K Q+ + ++ +H +V+H DIKP N+ G K D GL + A S GT YY++PE I Y++K+DIWS G +L EM + PF+ + SL K+++ + P+ + S+EL +L+N+C+ +P++RP
Sbjct: 31 LANFRIEKKIGRGQFSEVYRASCLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIED---NELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALDHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLV------GTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSL-CKKIEQCDYPPLPSDHYSEELRQLVNICINPDPEKRP 283
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Nek7 (NIMA (never in mitosis gene a)-related expressed kinase 7 [Source:MGI Symbol;Acc:MGI:1890645]) HSP 1 Score: 111.309 bits (277), Expect = 3.618e-26 Identity = 77/263 (29.28%), Postives = 130/263 (49.43%), Query Frame = 1
Query: 1435 LENFDLGKEIARGGFGIVFHCQEKISGKNVILKK-----LIDKKLTS-FYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPI--NPISKELNELINLCLTVNPDERP 2199
L NF + K+I RG F V+ + G V LKK L+D K + ++I + LN + ++D +N+ + G L+ I+ KQ + + E+ + K Q+ + ++ +H +V+H DIKP N+ G K D GL + A S GT YY++PE I Y++K+DIWS G +L EM + PF+ + SL K+++ + P+ + S+EL +L+N+C+ +P++RP
Sbjct: 31 LANFRIEKKIGRGQFSEVYRASCLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIED---NELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALDHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLV------GTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSL-CKKIEQCDYPPLPSDHYSEELRQLVNICINPDPEKRP 283
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:MGI Symbol;Acc:MGI:1346873]) HSP 1 Score: 115.161 bits (287), Expect = 6.615e-26 Identity = 87/276 (31.52%), Postives = 139/276 (50.36%), Query Frame = 1
Query: 1441 NFDLGKEIARGGFGIVFHCQEKISGKNVILKKL--------IDKKLTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINP-----ISKELNELINLCLTVNPDERPTGEELMKSEF 2229
N+ LGK + +G FG V+ C + +G+ + +K++ K++ + +I + +L E +V + ++D + ++++ M YM GGS I+ LK + L E K + QIL ++ LH ++H DIK NI+ D GN K D+G +K RL+ S +S GT Y+++PEVI GE Y K DIWS +VEM+T KPP WA + + K +P NP +S + + V RP+ EEL++ F
Sbjct: 355 NWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFNPESPETSKEVNALECEIQLLKNLLH-ERIVQYYGCLRDPQEKTLSIFMEYMPGGS----IKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNIKLGDFGASK---RLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPP--WAEFE----AMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIF-VEAKLRPSAEELLRHMF 615
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Myo3a (myosin IIIA [Source:MGI Symbol;Acc:MGI:2183924]) HSP 1 Score: 113.62 bits (283), Expect = 3.724e-25 Identity = 82/294 (27.89%), Postives = 143/294 (48.64%), Query Frame = 1
Query: 1393 PFQGGGILFEKMKR-LENFDLGKEIARGGFGIVFHCQEKISGKNVILKKL-----IDKKLTSFYRDIFISYHLNQAEHLVNGFEIV---QDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGE-----LYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINPISKELNELINLCLTVNPDERPTGEELMKSEFF 2232
P G I+F+ + +++ + I +G +G VF K SG+ +K L ID+++ + Y I L+ ++V + I N + L + +GGS+T ++ LK+ + + E I I ++ L + LH K IH D+K +NI+ EG K +D+G++ + + +R R +S GT +++APEVI E Y + D WS G+ +E+ G PP R ++ + K + S E N+ I+ CLT + ++RPT +L+K +F
Sbjct: 3 PLIGKTIIFDNFPDPSDTWEIIETIGKGTYGKVFKVLNKKSGQKAAVKILDPIHDIDEEIEAEYN---ILRTLSDHPNVVRFYGIYFKKDKINGDKLWLVLELCNGGSVTDLVKGFLKRGERMSEPVIAYILHEALMGLQHLHSNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQL------SSTRHRLNTSVGTPFWMAPEVIACEQQLDTTYDARCDTWSLGITAIELGDGDPPLAELHPMRALFKIPRNPPPKLRQPELWSAEFNDFISKCLTKDYEKRPTVSDLLKHKFI 287
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q10407|MKH1_SCHPO (MAP kinase kinase kinase mkh1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=mkh1 PE=3 SV=1) HSP 1 Score: 127.487 bits (319), Expect = 1.978e-28 Identity = 94/299 (31.44%), Postives = 154/299 (51.51%), Query Frame = 1
Query: 1453 GKEIARGGFGIVF-----HCQEKISGKNVILKKLIDKKLTSFYRDIFISY-----------HLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKG--ELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKP---INPISKELNELINLCLTVNPDERPTGEELMKSEFFKDCLHK*HFIITLLYSII 2286
G+ I G +G VF + E I+ K V + + I+ + +DI S HLN ++L GFE + I++ + Y+SGGS I +CL+ + +E+ + +S Q+L ++ LH +IH D+K DN++ D +G K D+G++KH + + + S G+I+++APEVI + YS K D+WS G V++EM+ G+ P+ + +L KK P ++ +S E + +N C TVN D RPT EEL+ F K C + +F T LY ++
Sbjct: 828 GELIGNGTYGKVFLAMNINTGELIAVKQVEIPQTINGRHDQLRKDIVDSINAEISMIADLDHLNIVQYL--GFEKTE----TDISIFLEYVSGGS----IGRCLRNYGPFEEQLVRFVSRQVLYGLSYLHSKGIIHRDLKADNLLIDFDGVCKISDFGISKHSDNVYDNDANL----SMQGSIFWMAPEVIHNDHQGYSAKVDVWSLGCVVLEMLAGRRPWSTDEAIQAMFKLGTEKKAPPIPSELVSQVSPEAIQFLNACFTVNADVRPTAEELLNHPFMK-CDEEFNFKDTNLYDML 1111
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q99759|M3K3_HUMAN (Mitogen-activated protein kinase kinase kinase 3 OS=Homo sapiens OX=9606 GN=MAP3K3 PE=1 SV=2) HSP 1 Score: 121.709 bits (304), Expect = 3.995e-27 Identity = 87/278 (31.29%), Postives = 140/278 (50.36%), Query Frame = 1
Query: 1441 NFDLGKEIARGGFGIVFHCQEKISGKNVILKKL--------IDKKLTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINP-----ISKELNELINLCLTVNPDERPTGEELMKSEFFK 2235
N+ GK + +G FG V+ C + +G+ + K++ K++++ +I + +L Q E +V + ++D + ++ + M YM GGS ++ LK + L E K + QIL ++ LH ++H DIK NI+ D GN K D+G +K RL+ S S GT Y+++PEVI GE Y K D+WS G +VEM+T KPP WA + + K +P NP IS+ + + V +RP+ EEL+ F +
Sbjct: 361 NWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNL-QHERIVQYYGCLRDRAEKTLTIFMEYMPGGS----VKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASK---RLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPP--WAEYE----AMAAIFKIATQPTNPQLPSHISEHGRDFLRRIF-VEARQRPSAEELLTHHFAQ 623
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9S7U9|M2K2_ARATH (Mitogen-activated protein kinase kinase 2 OS=Arabidopsis thaliana OX=3702 GN=MKK2 PE=1 SV=2) HSP 1 Score: 117.087 bits (292), Expect = 8.506e-27 Identity = 82/275 (29.82%), Postives = 134/275 (48.73%), Query Frame = 1
Query: 1435 LENFDLGKEIARGGFGIVFHCQEKISGKNVILKKLIDKKLTSFYRDIFISYHLNQAEHLVNGFEIVQD-YNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECK-VIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFH-------WAGIGRVSLELTKMKKYKFKPINPISKELNELINLCLTVNPDERPTGEELMKSEFF 2232
L + D+ K I +G G+V Q K +G+ LK + + + I +NQ+ N Q Y++G+I+L + YM GGSL + LK K + + ++ I Q+L + LH + +IH D+KP N++ + G K D+G++ + G A + GT Y++PE I G Y K+DIWS G+V++E TGK P+ W + + +E + P S EL+ I+ CL +P+ R + +ELM+ F
Sbjct: 67 LSDLDMVKVIGKGSSGVVQLVQHKWTGQFFALKVIQLNIDEAIRKAIAQELKINQSSQCPNLVTSYQSFYDNGAISLILEYMDGGSLADF----LKSVKAIPDSYLSAIFRQVLQGLIYLHHDRHIIHRDLKPSNLLINHRGEVKITDFGVSTVMTNTAGLANTFV------GTYNYMSPERIVGNKYGNKSDIWSLGLVVLECATGKFPYAPPNQEETWTSVFEL-MEAIVDQPPPALPSGNFSPELSSFISTCLQKDPNSRSSAKELMEHPFL 330
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|P32491|MKK2_YEAST (MAP kinase kinase MKK2/SSP33 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=MKK2 PE=1 SV=2) HSP 1 Score: 119.398 bits (298), Expect = 1.086e-26 Identity = 86/267 (32.21%), Postives = 138/267 (51.69%), Query Frame = 1
Query: 1462 IARGGFGIVFHCQEKISGKNVILKKLIDKKLT--SFYRDIFISYHLNQA---EHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPF-------HWAGIGRVSLELTKMKKYKFKPINPI--SKELNELINLCLTVNPDERPTGEELMK 2220
+ G G V C+ K +GK V K I+ T + + IF N++ +++V + + D SI +AM YM G SL + + LK+ + E+ I KI+ +L ++ LHE KVIH DIKP NI+ + +G K D+G++ E + A + GT +Y+APE I+G+ YS D+WS G+ L+E+ G+ PF + A I +++ LT + K +P I SK I+ CL + ERP+ +++K
Sbjct: 220 LGEGAGGSVAKCRLK-NGKKVFALKTINTMNTDPEYQKQIFRELQFNKSFKSDYIVQYYGMFTDEQSSSIYIAMEYMGGKSLEATYKNLLKRGGRISERVIGKIAESVLRGLSYLHERKVIHRDIKPQNILLNEKGEIKLCDFGVSG--EAVNSLAMTFT------GTSFYMAPERIQGQPYSVTCDVWSLGLTLLEVAGGRFPFESDKITQNVAPIELLTMILTFSPQLKDEPELDISWSKTFRSFIDYCLKKDARERPSPRQMLK 477
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q61084|M3K3_MOUSE (Mitogen-activated protein kinase kinase kinase 3 OS=Mus musculus OX=10090 GN=Map3k3 PE=1 SV=1) HSP 1 Score: 119.013 bits (297), Expect = 3.167e-26 Identity = 87/278 (31.29%), Postives = 139/278 (50.00%), Query Frame = 1
Query: 1441 NFDLGKEIARGGFGIVFHCQEKISGKNVILKKL--------IDKKLTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINP-----ISKELNELINLCLTVNPDERPTGEELMKSEFFK 2235
N+ GK + +G FG V+ C + +G+ + K++ K++++ +I + +L Q E +V + ++D + + + M YM GGS ++ LK + L E K + QIL ++ LH ++H DIK NI+ D GN K D+G +K RL+ S S GT Y+++PEVI GE Y K D+WS G +VEM+T KPP WA + + K +P NP IS+ + + V +RP+ EEL+ F +
Sbjct: 361 NWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNL-QHERIVQYYGCLRDRAEKILTIFMEYMPGGS----VKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASK---RLQTICMSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPP--WAEYE----AMAAIFKIATQPTNPQLPSHISEHGRDFLRRIF-VEARQRPSAEELLTHHFAQ 623
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A1R2CRM4 (Protein kinase domain-containing protein OS=Stentor coeruleus OX=5963 GN=SteCoe_5689 PE=3 SV=1) HSP 1 Score: 141.739 bits (356), Expect = 4.221e-33 Identity = 90/272 (33.09%), Postives = 153/272 (56.25%), Query Frame = 1
Query: 1453 GKEIARGGFGIVFHCQEKISGKNVILK--------KLIDKKLTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPF-HWAGIGRVSLELTKMKKYKFKPINPISKE-LNELINLCLTVNPDERPTGEELMKSEFFKD 2238
G I G + V+ C I+G+ + LK + I+++ ++I + LN E++V+ ++ + S+++ + Y+ GGSL S L ++K L+ I S Q+L +N LH+ K+IH D+KP N++ G K D+G +K + LE +S G+ Y++APEV++ E +S+ DIWSFG +L+EMV+GKPP+ +++ + +EL + K P P ++ L E+I C+ NP+ERP+ EL++SEFFK+
Sbjct: 64 GDLIGEGAYAKVYQCLNIITGELLALKTFYISENPRKIEREFQQMRKEIRVLKTLNH-ENVVHYYQADLSEDLKSVDILLEYVPGGSLKS----ILIKYKSLEISVIKNYSRQLLRGLNYLHDNKIIHRDLKPANVLISPTGMLKLTDFGSSKQFDDLESNLS-----KSLKGSPYWMAPEVVRMEGHSFSADIWSFGCILIEMVSGKPPWSNYSNDSKAVMEL--ISKEGLLPDIPSTEPLLQEIITHCVNRNPNERPSPPELLESEFFKN 323
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A085ML90 (Protein kinase domain-containing protein OS=Trichuris suis OX=68888 GN=M513_01219 PE=3 SV=1) HSP 1 Score: 137.887 bits (346), Expect = 1.532e-31 Identity = 95/293 (32.42%), Postives = 147/293 (50.17%), Query Frame = 1
Query: 1375 QMNDGDPFQGGGILFEKMKRLENFDLGKEIARGGFGIVFHCQEK----ISGKNVILKKLI--DKKLTSFYRDIFISYHLNQAEHL-VNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINPISKELNELINLCLTVNPDERPTGEELMKSEFF 2232
+M P + M L++FDLG+++ RG FG VF +EK I V+ K + K R+I I HL L + G+ ++D + L + Y + G L S + Q K + L ++ Q++ +N LH KVIH D+K +NI+ +G K D+G A H R+E+ GT+ YL PE++ G + + DIWS G+++ EM+TGKPPF+ + T++ K FK + +S E +LI+ L +NPDERP+ EE+ K F
Sbjct: 75 EMVPSKPAAMAAEVKRHMWTLDDFDLGRQLGRGRFGRVFLAREKERQFIVALKVLFKSTVMKAKMENQVRREIEIQAHLKHPNILRLYGYF----HDDARVYLVLEYAAKGELYSMLTQAGKFTEDLTANYMA----QVVDAVNYLHTKKVIHRDLKLENILLSKDGKIKISDFGWAVHA--------PSSRRETLCGTVDYLPPEMVGGMQHDARVDIWSLGVLMYEMLTGKPPFYCSDQRETC---TRILKCTFKIPDEVSDEAKDLISKLLRLNPDERPSLEEVTKHPFI 348
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A085NMY2 (Protein kinase domain-containing protein OS=Trichuris suis OX=68888 GN=M514_01219 PE=3 SV=1) HSP 1 Score: 138.272 bits (347), Expect = 1.634e-31 Identity = 97/297 (32.66%), Postives = 148/297 (49.83%), Query Frame = 1
Query: 1375 QMNDGDPFQGGGILFEKMKRLENFDLGKEIARGGFGIVFHCQEK----ISGKNVILKKLI--DKKLTSFYRDIFISYHLNQAEHL-VNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCL----QEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINPISKELNELINLCLTVNPDERPTGEELMKSEFF 2232
+M P + M L++FDLG+++ RG FG VF +EK I V+ K + K R+I I HL L + G+ ++D + L + Y + G L S + Q K + L Q I+ Q++ +N LH KVIH D+K +NI+ +G K D+G A H R+E+ GT+ YL PE++ G + + DIWS G+++ EM+TGKPPF+ + T++ K FK + +S E +LI+ L +NPDERP+ EE+ K F
Sbjct: 75 EMVPSKPAAMAAEVKRHMWTLDDFDLGRQLGRGRFGRVFLAREKERQFIVALKVLFKSTVMKAKMENQVRREIEIQAHLKHPNILRLYGYF----HDDARVYLVLEYAAKGELYSMLTQAGKFTEDLTANVQSNSILFYMAQVVDAVNYLHTKKVIHRDLKLENILLSKDGKIKISDFGWAVHA--------PSSRRETLCGTVDYLPPEMVGGMQHDARVDIWSLGVLMYEMLTGKPPFYCSDQRETC---TRILKCTFKIPDEVSDEAKDLISKLLRLNPDERPSLEEVTKHPFI 356
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A1R2CWZ9 (Protein kinase domain-containing protein OS=Stentor coeruleus OX=5963 GN=SteCoe_3518 PE=3 SV=1) HSP 1 Score: 136.346 bits (342), Expect = 2.485e-31 Identity = 85/271 (31.37%), Postives = 150/271 (55.35%), Query Frame = 1
Query: 1453 GKEIARGGFGIVFHCQEKISGKNVILK--------KLIDKKLTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPF-HWAGIGRVSLELTKMKKYKFKPINPISKELNELINLCLTVNPDERPTGEELMKSEFFKD 2238
G I G + V+ C ++G+ + LK + I+++ ++I + LN E++V+ ++ + S+++ + Y+ GGSL S L ++K L+ I S Q+L + LH+ K+IH D+KP N++ G K D+G +K + LE SR K G+ Y++APEV++ E +S+ D+WSFG +L+EM +GKPP+ +++ ++ +EL K+ I L E+I C+ NP+ERP+ +EL++ +FFK+
Sbjct: 64 GDLIGEGAYAKVYQCLNIVTGELLALKTFYISENPRKIEREFQQMRKEIRVLKALNH-ENVVHYYQADLSEDLKSVDILLEYVPGGSLKS----ILVKYKSLEISVIRNYSRQLLEGLKYLHDNKIIHRDLKPANVLISPTGVLKLTDFGSSKQFDDLESNL-SRSLK----GSPYWMAPEVVRMEGHSFSADVWSFGCILIEMTSGKPPWSNYSNDSKIVMELIS-KEGSLPDIPSTEPLLQEIITQCVNRNPNERPSPQELLEKDFFKN 323
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: S9UAZ3 (Protein kinase OS=Angomonas deanei OX=59799 GN=AGDE_11629 PE=4 SV=1) HSP 1 Score: 135.961 bits (341), Expect = 5.178e-31 Identity = 91/288 (31.60%), Postives = 154/288 (53.47%), Query Frame = 1
Query: 1414 LFEKMKRLENFDLGKEIARGGFGIVFHC----QEKISGKNVILKKLIDKK-LTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGE-LYSYKTDIWSFGMVLVEMVTGKPPFH-----WAGIGRVSLELTKMKKYKFKPINPISKELNELINLCLTVNPDERPTGEELMKSEFFKDCL 2244
+F K LEN+ K I +G FG VF Q + K V L +++K+ L + +I + + Q ++V + +QD + +IN+ M ++GGSL S I K++K + K + + +YQI+ + LHEC ++H DIK DN++ +G K D+G +K ++ + + + GT Y++APEVIK E Y K+DIWS G +VEM+TG+PP+ WA + +++ T + K I+P +L L+ C +P +RPT ++++ F +
Sbjct: 59 VFLSEKDLENWQKVKTIGKGSFGAVFEALLANQRTVCVKVVELGSIVEKEELEKLHNEIALMKRM-QHPNIVQYYGSLQDTSKNTINIFMELVTGGSLNSVI----KKFKTIPRKTLQQWTYQIVLGVKYLHECGIVHRDIKGDNVLVTPDGIIKLADFGCSKSIDDV---CSATHGCSTMVGTPYWMAPEVIKCEGGYGAKSDIWSIGCTIVEMLTGRPPWPECNSMWAAVYKIA-NSTGLPTEIPKDIDP---QLMNLLEKCFERDPRKRPTAAQMLEHPFLAGVM 334
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:103034596]) HSP 1 Score: 125.176 bits (313), Expect = 3.634e-29 Identity = 86/272 (31.62%), Postives = 140/272 (51.47%), Query Frame = 1
Query: 1453 GKEIARGGFGIVFHCQEKISGKNVILKKL--------IDKKLTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINPI-----SKELNELINLCLTVNPDERPTGEELMKSEF 2229
GK + +G FG V+ C + +G+ + K++ K++++ +I + +L+ E +V + ++D+N+ ++ + M YM GGS ++ LK + L E K + QIL ++ LH ++H DIK NI+ D GN K D+G +K RL+ S S GT Y+++PEVI G+ Y K D+WS G +VEM+T KPP WA + + K +P NPI S++ + I V RP+ EEL++ F
Sbjct: 359 GKLLGQGAFGRVYLCYDVDTGRELAAKQVQFDPASPETSKEVSTLECEIQLLKNLHH-ERIVQYYGCLRDHNEKTLTIFMEYMPGGS----VKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASK---RLQTICMSSTGVRSVTGTPYWMSPEVISGDGYGRKADVWSLGCTVVEMLTEKPP--WAEYE----AMAAIFKIATQPTNPILPSHTSEQTRDFIRRIF-VEAKHRPSAEELLRHPF 615
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:103034596]) HSP 1 Score: 125.176 bits (313), Expect = 3.634e-29 Identity = 86/272 (31.62%), Postives = 140/272 (51.47%), Query Frame = 1
Query: 1453 GKEIARGGFGIVFHCQEKISGKNVILKKL--------IDKKLTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINPI-----SKELNELINLCLTVNPDERPTGEELMKSEF 2229
GK + +G FG V+ C + +G+ + K++ K++++ +I + +L+ E +V + ++D+N+ ++ + M YM GGS ++ LK + L E K + QIL ++ LH ++H DIK NI+ D GN K D+G +K RL+ S S GT Y+++PEVI G+ Y K D+WS G +VEM+T KPP WA + + K +P NPI S++ + I V RP+ EEL++ F
Sbjct: 359 GKLLGQGAFGRVYLCYDVDTGRELAAKQVQFDPASPETSKEVSTLECEIQLLKNLHH-ERIVQYYGCLRDHNEKTLTIFMEYMPGGS----VKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASK---RLQTICMSSTGVRSVTGTPYWMSPEVISGDGYGRKADVWSLGCTVVEMLTEKPP--WAEYE----AMAAIFKIATQPTNPILPSHTSEQTRDFIRRIF-VEAKHRPSAEELLRHPF 615
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:103034596]) HSP 1 Score: 125.176 bits (313), Expect = 3.634e-29 Identity = 86/272 (31.62%), Postives = 140/272 (51.47%), Query Frame = 1
Query: 1453 GKEIARGGFGIVFHCQEKISGKNVILKKL--------IDKKLTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINPI-----SKELNELINLCLTVNPDERPTGEELMKSEF 2229
GK + +G FG V+ C + +G+ + K++ K++++ +I + +L+ E +V + ++D+N+ ++ + M YM GGS ++ LK + L E K + QIL ++ LH ++H DIK NI+ D GN K D+G +K RL+ S S GT Y+++PEVI G+ Y K D+WS G +VEM+T KPP WA + + K +P NPI S++ + I V RP+ EEL++ F
Sbjct: 359 GKLLGQGAFGRVYLCYDVDTGRELAAKQVQFDPASPETSKEVSTLECEIQLLKNLHH-ERIVQYYGCLRDHNEKTLTIFMEYMPGGS----VKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASK---RLQTICMSSTGVRSVTGTPYWMSPEVISGDGYGRKADVWSLGCTVVEMLTEKPP--WAEYE----AMAAIFKIATQPTNPILPSHTSEQTRDFIRRIF-VEAKHRPSAEELLRHPF 615
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:NCBI gene;Acc:103026704]) HSP 1 Score: 119.783 bits (299), Expect = 1.817e-27 Identity = 87/276 (31.52%), Postives = 141/276 (51.09%), Query Frame = 1
Query: 1441 NFDLGKEIARGGFGIVFHCQEKISGKNVILKKL--------IDKKLTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINP-----ISKELNELINLCLTVNPDERPTGEELMKSEF 2229
N+ LGK + +G FG VF C + +G+ + +K++ K++++ +I + +L E +V + ++D ++ ++++ M YM GGS I+ LK + L E K + QIL + LH ++H DIK NI+ D GN K D+G ++ RL+ S +S GT Y+++PEVI GE Y K DIWS G +VEM+T +PP WA + + K +P NP +S + + V +RP EEL++ F
Sbjct: 358 NWRLGKLLGQGAFGRVFLCYDADTGRELAVKQVQFDPDSPETSKEVSALECEIQLLKNLFH-ERIVQYYGCLRDTHERTLSIFMEYMPGGS----IKDQLKSYGALTENVTRKYTRQILEGVCYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASR---RLQTICLSGTGIKSVTGTPYWMSPEVISGEGYGRKADIWSVGCTVVEMLTLRPP--WAEFE----AMAAIFKIATQPTNPALPAHVSDHCRDFLKRIF-VETKQRPAAEELLRHIF 618
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: map3k19 (mitogen-activated protein kinase kinase kinase 19 [Source:ZFIN;Acc:ZDB-GENE-081104-140]) HSP 1 Score: 113.235 bits (282), Expect = 3.432e-27 Identity = 80/272 (29.41%), Postives = 137/272 (50.37%), Query Frame = 1
Query: 1453 GKEIARGGFGIVFHCQEKISGKNVILKKLI---------DKKLTSFYRDIFISYHLNQAEHL-VNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINP--ISKELNELINLCLTVNPDERPTGEELMKSEFF 2232
G+ + RG +G V+ C G+ + +K+++ +K+ + R++ + L EH + GF + D I++ M Y+ GGS++S L ++ L EK + Q+L + LHE +VIH D+K +N++ G K ID+G A+ + RL + +S GT Y++APEVI + K+D+WS G + EM TGKPP A +G+++ + P P S+E + CL +N +RP+ +L++ F
Sbjct: 19 GEVLGRGAYGTVY-CGLTSQGQLIAVKQVLLDVSTSETAEKEYSRLEREVDL---LKNLEHPNIVGF-LGTALTDNVISIFMEYVPGGSISS----VLNRFGPLPEKVFALYTRQVLEGVAYLHENRVIHRDLKGNNLMLMPTGVVKLIDFGCARRLNRLTHSGGNSDLLKSVHGTPYWMAPEVINETGHGKKSDVWSIGCTVFEMATGKPPL--AHMGKMAALFYIGARKGLMPPLPDDFSEEAKSFVKACL-INQKQRPSAADLLRHPFI 278
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:ZFIN;Acc:ZDB-GENE-120215-96]) HSP 1 Score: 119.398 bits (298), Expect = 5.909e-28 Identity = 84/276 (30.43%), Postives = 141/276 (51.09%), Query Frame = 1
Query: 1441 NFDLGKEIARGGFGIVFHCQEKISGKNVILKKL--------IDKKLTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINP-----ISKELNELINLCLTVNPDERPTGEELMKSEF 2229
N+ GK + +G FG V+ C + +G+ + +K++ K++ + +I + +L Q E +V F ++D ++++ M YM GGS I+ L+ + L E K + QIL ++ LH ++H DIK NI+ D GN K D+G +K ++ + + + + S GT Y+++PEVI GE Y K DIWS G +VEM+T KPP WA + + K +P +P S+ +L+ V RP+ E+L++ F
Sbjct: 358 NWQRGKLLGQGAFGRVYLCYDADTGRELAVKQVQFDPGSVETSKEVNALECEIQLLKNL-QHERIVQYFGCLRDPQQKTLSIFMEYMPGGS----IKDQLRAYGALTENVTRKYTRQILEGVSFLHGNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICSQGTAMR---SVTGTPYWMSPEVINGEGYGRKADIWSVGCTVVEMLTEKPP--WAEFE----AMAAIFKIATQPTDPRLPLHASEHARDLLRRIF-VEAKLRPSAEDLLRHPF 618
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: slka (STE20-like kinase a [Source:ZFIN;Acc:ZDB-GENE-050411-66]) HSP 1 Score: 104.375 bits (259), Expect = 7.230e-23 Identity = 80/270 (29.63%), Postives = 129/270 (47.78%), Query Frame = 1
Query: 1459 EIARGGFGIVFHCQEKISGKNVILKKLIDKKLTSFYRDIFISYH-LNQAEH-----LVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGL-AKHVERLEGKAQSRKRKESSPGTIYYLAPEVI-----KGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINPISKELNELINLCLTVNPDERPTGEELMKSEFF 2232
E+ G FG V+ Q K SG + K+I+ K D + L +H L+N F Y + + + + + GG++ + + L+ + L E I + Q+L +N LH ++IH D+K NI+ EG+ K D+G+ AK+ L+ R++S GT Y++APEV+ K Y YK DIWS G+ L+E+ +PP H RV L++ K + S E + + CL NP+ R +L++ F
Sbjct: 38 ELGDGAFGKVYKAQNKESG-VLAAAKVIETKSEEELEDYMVEIEILALCDHPNIVGLLNAF-----YYENKLWIFIEFCPGGAVDAIM---LELERGLAEPQIRVVCKQMLEALNYLHTHRIIHRDLKAGNILLTFEGDVKLADFGVSAKNTRTLQ-------RRDSFIGTPYWMAPEVVMCETMKDAPYDYKADIWSLGITLIELAQMEPPNHELNPMRVMLKIAKNDPPSLSFPSKWSAEFTDFLKKCLDKNPETRWNALQLLQHSFI 291
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: nek2 (NIMA-related kinase 2 [Source:ZFIN;Acc:ZDB-GENE-040426-752]) HSP 1 Score: 98.9821 bits (245), Expect = 5.758e-22 Identity = 64/219 (29.22%), Postives = 114/219 (52.05%), Query Frame = 1
Query: 1606 HLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECK-----VIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPIN-PISKELNELINLCLTVNPDERPTGEELMKSEFFKDCL 2244
++V F+ + D ++ ++ + M Y G L S I +C + + L+E+ ++++ Q++ + E H V+H D+KP N+ D N K D+GLA+ ++ A++ GT YY++PE Y+ K+DIWS G +L E+ PPF +++ K+K+ KF+ I S ELNE+I+ L + RP+ E++M+ + L
Sbjct: 35 NIVRYFDRIIDRSNTTLYIVMEYCECGDLASLISRCRRDRRFLEEEFVLRVLAQLVLALRECHRRTAGGRTVLHRDLKPANVFLDARHNVKLGDFGLARILQHDTSFAKT------FVGTPYYMSPEQFSRMSYNEKSDIWSLGCLLYELCALVPPFTAMNQKQLA---EKIKEGKFRRIPYRYSDELNEIISKMLNLKDYLRPSIEQIMQYGLLAEVL 244
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: map2k6 (mitogen-activated protein kinase kinase 6 [Source:NCBI gene;Acc:65239]) HSP 1 Score: 96.6709 bits (239), Expect = 1.096e-21 Identity = 72/267 (26.97%), Postives = 126/267 (47.19%), Query Frame = 1
Query: 1459 EIARGGFGIVFHCQEKISGKNVILKKLI----DKKLTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELH-ECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGEL----YSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINPISKELNELINLCLTVNPDERPTGEELMKSEFF 2232
E+ RG +G+V + SG + +K++ ++ D+ IS + V + + + +G + + M M SL + ++ +++ + E + KIS I+ + LH + VIH D+KP N++ + +G+ K D+G++ ++ K G Y+APE I E+ Y+ K+DIWS G+ ++E+ K P+ G L+ + P S E + LCL NP+ERPT ELM + FF
Sbjct: 71 ELGRGAYGVVERVRHTPSGTIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPYTVTFYGAL--FREGDVWICMELMDT-SLDKFYKKVIEKGLTIPEDILGKISVAIVKALEHLHSKLSVIHRDVKPSNVLINTQGHVKMCDFGISGYLVDSVAKTLDA-------GCKPYMAPERINPEINQKGYNVKSDIWSLGITMIELAILKFPYESWGTPFQQLKQVVEEPSPQLPPENFSPEFVDFSTLCLKKNPNERPTYAELMDNTFF 327
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: pak4 (p21 protein (Cdc42/Rac)-activated kinase 4 [Source:ZFIN;Acc:ZDB-GENE-040704-69]) HSP 1 Score: 98.2117 bits (243), Expect = 2.937e-21 Identity = 74/274 (27.01%), Postives = 127/274 (46.35%), Query Frame = 1
Query: 1435 LENFDLGKEIARGGFGIVFHCQEKISGKNVILKKLIDKKLTS---FYRDIFI--SYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINPISKELNELINLCLTVNPDERPTGEELMKSEFFKDC 2241
LENF +I G G+V ++ SG+ V +KK+ +K + ++ I YH + N + + + + + M ++ GG+LT + + E+ I + +L + LH VIH DIK D+I+ +G K D+G V ++ R++S GT Y++APEVI Y + D+WS G++++EMV G+PP+ + + K K I S L ++ L +P R T EL++ F ++
Sbjct: 419 LENF---IKIGEGSTGVVCLAVDRRSGRQVAVKKMHLRKQQRRELLFNEVVIMREYHHENVVDMYNSYLVADE-----LWVVMEFLEGGALTDIVTHTR-----MNEEQIATVCVSVLRALAYLHGQGVIHRDIKSDSILLTADGRIKLSDFGFCAQV------SKEVTRRKSLVGTPYWMAPEVISRLPYGPEVDVWSLGIMVIEMVDGEPPYFNEPPLQAMRRIRDNVPPKMKNIQKASPLLRGFLDQMLVRDPALRATALELLQHPFLQNA 673
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: MKK2 (MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication [Source:SGD;Acc:S000006061]) HSP 1 Score: 119.398 bits (298), Expect = 1.564e-28 Identity = 86/267 (32.21%), Postives = 138/267 (51.69%), Query Frame = 1
Query: 1462 IARGGFGIVFHCQEKISGKNVILKKLIDKKLT--SFYRDIFISYHLNQA---EHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPF-------HWAGIGRVSLELTKMKKYKFKPINPI--SKELNELINLCLTVNPDERPTGEELMK 2220
+ G G V C+ K +GK V K I+ T + + IF N++ +++V + + D SI +AM YM G SL + + LK+ + E+ I KI+ +L ++ LHE KVIH DIKP NI+ + +G K D+G++ E + A + GT +Y+APE I+G+ YS D+WS G+ L+E+ G+ PF + A I +++ LT + K +P I SK I+ CL + ERP+ +++K
Sbjct: 220 LGEGAGGSVAKCRLK-NGKKVFALKTINTMNTDPEYQKQIFRELQFNKSFKSDYIVQYYGMFTDEQSSSIYIAMEYMGGKSLEATYKNLLKRGGRISERVIGKIAESVLRGLSYLHERKVIHRDIKPQNILLNEKGEIKLCDFGVSG--EAVNSLAMTFT------GTSFYMAPERIQGQPYSVTCDVWSLGLTLLEVAGGRFPFESDKITQNVAPIELLTMILTFSPQLKDEPELDISWSKTFRSFIDYCLKKDARERPSPRQMLK 477
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: MKK1 (MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication [Source:SGD;Acc:S000005757]) HSP 1 Score: 113.62 bits (283), Expect = 1.170e-26 Identity = 91/308 (29.55%), Postives = 150/308 (48.70%), Query Frame = 1
Query: 1372 DQMNDGDPFQGGGILFEKMK-RLENFDLGKEIARGGFGIVFHCQEKISGKNVILKKLIDKKLT--SFYRDIFISYHLN---QAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFH----WAGIGRVSLE---LTKMKKYKFKPINPI--SKELNELINLCLTVNPDERPTGEELMKSEFFKDCLHK 2250
+ + D D G + +K R+E + + G G V C+ K +G + K+I+ T + + IF N Q+E++V + + D + SI +AM YM G SL + + L++ + EK + KI+ +L ++ LHE KVIH DIKP NI+ + G K D+G++ E + A + GT +Y+APE I+G+ YS +D+WS G+ ++E+ GK P A I L LT + K +P + I S I+ CL + ERP+ +++ + K + K
Sbjct: 199 NSVRDVDQLDENGWKYANLKDRIETLGI---LGEGAGGSVSKCKLK-NGSKIFALKVINTLNTDPEYQKQIFRELQFNRSFQSEYIVRYYGMFTDDENSSIYIAMEYMGGRSLDAIYKNLLERGGRISEKVLGKIAEAVLRGLSYLHEKKVIHRDIKPQNILLNENGQVKLCDFGVSG--EAVNSLATTFT------GTSFYMAPERIQGQPYSVTSDVWSLGLTILEVANGKFPCSSEKMAANIAPFELLMWILTFTPELKDEPESNIIWSPSFKSFIDYCLKKDSRERPSPRQMINHPWIKGQMKK 494
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: KIC1 (Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis [Source:SGD;Acc:S000001144]) HSP 1 Score: 109.383 bits (272), Expect = 1.291e-24 Identity = 85/263 (32.32%), Postives = 134/263 (50.95%), Query Frame = 1
Query: 1462 IARGGFGIVFHCQEKISGKNVILKKL-IDK---KLTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVI-KGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINPISKELNELINLCLTVNPDERPTGEELMKSEFFK 2235
I RG FG+V+ +G+ +K L +D ++ R+I L Q ++ + D S+ + M + +GGSL S L+ K + EK+I I ++L + +H+ VIH DIK N++ EGN K D+G+A V Q+ R+++ GT Y++APEVI +G Y K DIWS G+ E+ TG PP+ R + K K + + + S L E I LCL +P ER + ++L+KS+F +
Sbjct: 29 IGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQFLASLKQISNITRYYGSY--LKDTSLWIIMEHCAGGSLRS----LLRPGK-IDEKYIGVIMRELLVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAAQVN------QTSLRRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSLGITTYEIATGNPPYCDVEALRAMQLIIKSKPPRLEDRS-YSTSLKEFIALCLDEDPKERLSADDLLKSKFIR 277
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: STE20 (Cdc42p-activated signal transducing kinase; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p; member of the PAK (p21-activated kinase) family [Source:SGD;Acc:S000000999]) HSP 1 Score: 108.227 bits (269), Expect = 2.326e-24 Identity = 63/197 (31.98%), Postives = 100/197 (50.76%), Query Frame = 1
Query: 1648 GSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINPISKELNELINLCLTVNPDERPTGEELMKSEFFKD 2238
G + + M YM GGSLT + C+ L E I + + L+ + LH V+H DIK DNI+ EG+ K D+G + L K + + GT Y++APEV+ + Y K DIWS G++++EM+ G+PP+ R + K K +S L + ++ CL V P++R + EL+ E+ +
Sbjct: 688 GDLWVIMEYMEGGSLTDVVTHCI-----LTEGQIGAVCRETLSGLEFLHSKGVLHRDIKSDNILLSMEGDIKLTDFGFCAQINELNLK------RTTMVGTPYWMAPEVVSRKEYGPKVDIWSLGIMIIEMIEGEPPYLNETPLRALYLIATNGTPKLKEPENLSSSLKKFLDWCLCVEPEDRASATELLHDEYITE 873
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: SPS1 (Putative protein serine/threonine kinase; localizes to the nucleus and cytoplasm; required for efficient spore packaging, prospore membrane development and closure and localization of enzymes involved in spore wall synthesis; interacts with and required for Ssp1p phosphorylation and turnover; member of the GCKIII subfamily of STE20 kinases; multiply phosphorylated on S/T residues; interacts with 14-3-3 proteins, Bmh1p and Bmh2p; expressed at the end of meiosis [Source:SGD;Acc:S000002931]) HSP 1 Score: 104.76 bits (260), Expect = 6.772e-24 Identity = 76/265 (28.68%), Postives = 130/265 (49.06%), Query Frame = 1
Query: 1462 IARGGFGIVFHCQEKISGKNVILKKL----IDKKLTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGEL--YSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINPISKELNELINLCLTVNPDERPTGEELMKSEFFKD 2238
I RG FG V+ ++++ + V +K + D+ + ++IF L L+ + I D S+ + M Y GGS + +++ L E+ + I +++ + LHE + IH DIK NI+ + EG K D+G++ H+ +S ++++ GT Y++APEV+ E+ Y+ K DIWS G+ E++ G PP +V L K K K + P S + + CL P +RP+ L+ EF K+
Sbjct: 24 IGRGNFGDVYKAVDRVTQEIVAIKVVNLEHSDEDIELLAQEIFFLAELKSP--LITNY-IATMLEDVSMWIVMEYCGGGSCSDLLKRSY--VNGLPEEKVSFIIHEVTLGLKYLHEQRKIHRDIKAANILLNEEGMVKLGDFGVSGHI-------RSTLKRDTFVGTPYWMAPEVVCCEVDGYNEKADIWSLGITTYELLKGLPPLSKYDPMKVMTNLPKRKPPKLQ--GPFSDAAKDFVAGCLVKTPADRPSAYNLLSFEFVKN 274
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO41410 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4G7]) HSP 1 Score: 126.716 bits (317), Expect = 2.012e-32 Identity = 92/278 (33.09%), Postives = 140/278 (50.36%), Query Frame = 1
Query: 1435 LENFDLGKEIARGGFGIVFHCQEKISGKNVILKKLIDKKLTSFYRDIFISYHLNQAEHLVNGFE---IVQDY----NDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINP--ISKELNELINLCLTVNPDERPTGEELMKSEFFKDC 2241
+ N+ GK + G FG V+ C + +G+ + +K++ +L S ++ + L + F IVQ Y +D I + M Y+ GGS I + +KQ L E K S QIL I LH +++H DIK NI+ D GN K D+G +K ++ + K R S GT Y++APEVI GE Y K D+WS G +VEM+T KPP WA ++ L K+ +P P +S + E + L +N RP+ +EL++ F +
Sbjct: 1 MNNWRKGKLLGAGAFGQVYMCHDLDTGRELAVKQIETGQLNSSTKNEVKA--LEGEIEFMKAFRNERIVQYYGIETDDLHIYIFMEYLPGGS----IHEHIKQHGALNESLTRKYSRQILEGILYLHTNRIVHRDIKGANILRDLYGNVKLADFGASKRLQTIRSKTGFR----SVHGTPYWMAPEVINGEGYGRKADVWSVGCTVVEMLTTKPP--WADFEPMA-ALFKIATQPTEPELPSDLSVDAVEFVRSTLRMNSKSRPSADELLRFSFVTNS 265
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO35437 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SLH0]) HSP 1 Score: 117.087 bits (292), Expect = 1.118e-28 Identity = 95/315 (30.16%), Postives = 141/315 (44.76%), Query Frame = 1
Query: 1309 EIARNCGASVEDFYCINISNHDQMNDGDPFQGGGILFEKMKR----LENFDLGKEIARGGFGIVFHCQEKISGKNVILKKLIDKKLT------SFYRDIFISYHL--NQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAG-------IGRVSLELTKMKKYKFKPINPISKELNELINLCLTVNPDER 2196
+I N + + +I+ H + + G PF+ L E MK+ L +FD+GK + +G FG V+ +EK S V LK L +L R+I I HL N L F Y+D + L + Y G L + C K EK K Q+ + H KVIH DIKP+N++ + +G+ K D+G + H R+ + GT+ YL PE+I+G+ + K D+WS G++ E + GKPPF G I RV L +S +LI+ L NP+ R
Sbjct: 3 KIPSNTHQTTVSSFNPSITKHMKGSKGGPFK----LLENMKQGKWNLSDFDIGKPLGKGKFGNVYLAREKKSKYIVALKVLFKSQLQKSNVEHQLRREIEIQSHLRHNNILRLFGYF-----YDDTRVYLILEYAPRGELYKELTACEK----FDEKRAAKYIRQLADALAYCHSKKVIHRDIKPENLLLNYKGDIKIADFGWSVHA--------PSSRRTTLCGTLDYLPPEMIEGKEHDEKVDLWSIGVLCYEFLVGKPPFEAEGHNETYRRISRVDLRFPSH----------VSPGARDLISKLLQHNPNNR 286
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO37413 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFU9]) HSP 1 Score: 113.235 bits (282), Expect = 1.317e-27 Identity = 77/277 (27.80%), Postives = 144/277 (51.99%), Query Frame = 1
Query: 1432 RLENFDLGKEIARGGFGIVFHCQEKISGKNVILKKLIDKKLTSFYRDIFISYHLN-----QAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECK----VIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPI-NPISKELNELINLCLTVNPDERPTGEELMKSEFF 2232
RL +++ + I G +GI + K K ++ K+L +++ + + +S +N + H+V ++ + D + +I + M + G L + I++ ++ + E + K+ YQ++ + E H K V+H D+KP N+ D N K D+GLA+ + A++ GT YY++PE + Y+ K+DIWS G ++ E+ PPF + ++ LE K+K +F PI + S L++LIN L VN + RP+ +EL+++ +
Sbjct: 5 RLHDYEELERIGSGSYGICKKIRRKKDNKVLVWKELDYGQMSETEKQMLVS-EVNLLRELKHPHIVRYYDRIIDRTNTTIYIVMEFCENGDLGALIKKHKREKRYTAEDLVWKLLYQLVLAVQECHRRKDGGHVLHRDLKPANVFLDANMNVKLGDFGLARVLSHDTSFAKT------FVGTPYYMSPEQVNKRSYNEKSDIWSLGCLMYELCALSPPF--TAMDQIRLE-AKIKVGRFHPIPSHYSSSLSQLINSMLQVNDEMRPSIDELLRNPYL 271
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO48741 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RIM4]) HSP 1 Score: 115.546 bits (288), Expect = 3.276e-26 Identity = 87/277 (31.41%), Postives = 139/277 (50.18%), Query Frame = 1
Query: 1441 NFDLGKEIARGGFGIVFHCQEKISGKNVILKKLI---DKKLTSFYRDIFISYHLNQAEH--LVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGL-AKHVERLEGKAQSRKRKESSPGTIYYLAPEVI-----KGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINPISKELNELINLCLTVNPDERPTGEELMKSEFFKD 2238
N++L E+ G FG V+ Q K K +I + +L F +I I L++ +H LV FE +DG + + + + SGG+L + L+ + L E I ++ Q+ + LH KVIH D+K N++ +GN K D+G+ AK+ + L+ ++ + GT Y++APEV+ K + Y YK DIWS G+ L+E+ PP H RV ++ K F N S +LN+ + C+ NPD R + E++K F D
Sbjct: 21 NWELVGELGDGSFGKVYKAQHKTESSLSAAKIIIVNDENELEDFMVEIDI---LSECKHKNLVGLFETF--LHDGKLWMMLEFCSGGALDDLM---LELERGLNEPEIRAVTRQLFEGLQFLHNHKVIHRDLKAGNLLLASDGNVKMADFGVSAKNKKTLQKRS-------TFIGTPYWMAPEVVVTETYKDDPYDYKADIWSAGITLIELAQMVPPNHNMHPMRVLFKIPKSDPPTFDNPNKWSNDLNDFLASCVVKNPDMRASATEMIKHPFIAD 282
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO34646 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SNS0]) HSP 1 Score: 108.227 bits (269), Expect = 9.124e-26 Identity = 75/263 (28.52%), Postives = 128/263 (48.67%), Query Frame = 1
Query: 1435 LENFDLGKEIARGGFGIVFHCQEKISGKNVILKK-----LIDKKLTS-FYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINP--ISKELNELINLCLTVNPDERP 2199
L NF++ K+I RG F +V+ + + + V LKK ++D K ++I + LN + +++ +N+ + G L+ I+ KQ + + E+ + K Q+ + +H +V+H DIKP N+ G K D GL + A S GT YY++PE IK Y++K+DIWS G +L EM + PF+ + SL K+++ + P+ S++L L++LC+ PD+RP
Sbjct: 18 LGNFEIEKKIGRGQFSVVYKARCTANNQIVALKKIQIFDMMDAKARQDCIKEIDLLKQLNHPNVIKYYASFIEN---NELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLTAALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLV------GTPYYMSPERIKENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSL-CKKIEQCDYPPLPAEHYSQQLRHLVSLCINPIPDQRP 270
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:101169290]) HSP 1 Score: 127.872 bits (320), Expect = 4.903e-30 Identity = 86/272 (31.62%), Postives = 143/272 (52.57%), Query Frame = 1
Query: 1453 GKEIARGGFGIVFHCQEKISGKNVILKKL--------IDKKLTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINPI-----SKELNELINLCLTVNPDERPTGEELMKSEF 2229
GK + +G FG+V+ C + +G+ + K++ K++++ +I + +L+ E +V + ++D+++ ++ + M YM GGS ++ LK + L E K + QIL ++ LH ++H DIK NI+ D GN K D+G +K RL+ S S GT Y+++PEVI GE Y K D+WS G +VEM+T KPP WA + + K +P NP+ S + + I+ C+ V RP+ EEL++ F
Sbjct: 356 GKLLGQGAFGLVYLCYDVDTGRELAAKQVQFDPDSPETSKEVSALECEIQLLKNLHH-ERIVQYYGCLRDHSEKTLTIFMEYMPGGS----VKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASK---RLQTICMSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPP--WAEYE----AMAAIFKIATQPTNPLLPSHTSDQARDFIH-CIFVEAKHRPSAEELLRHPF 612
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:NCBI gene;Acc:101160297]) HSP 1 Score: 116.316 bits (290), Expect = 3.214e-26 Identity = 84/276 (30.43%), Postives = 142/276 (51.45%), Query Frame = 1
Query: 1441 NFDLGKEIARGGFGIVFHCQEKISGKNVILKKL--------IDKKLTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINP-----ISKELNELINLCLTVNPDERPTGEELMKSEF 2229
N+ LGK + +G FG V+ C + +G+ + +K++ K++++ +I + +L E +V + ++D + ++++ M +M GGS I+ LK + L E + + QIL ++ LH ++H DIK NI+ D GN K D+G ++ RL+ S +S GT Y+++PEVI GE Y K DIWS G +VEM+T +PP WA + + K +P NP +S E + V +RP+ +EL++ F
Sbjct: 388 NWRLGKLLGQGAFGRVYLCYDADTGRELAVKQVQFDPESPETSKEVSALECEIQLLKNLCH-ERIVQYYGCLRDTMERTLSIFMEHMPGGS----IKDQLKSYGALTENVTRRYTRQILEGVSYLHSNMIVHRDIKGANILRDSVGNVKLGDFGASR---RLQTICLSGTGIKSVTGTPYWMSPEVISGEGYGRKADIWSVGCTVVEMLTQRPP--WAEFE----AMAAIFKIATQPTNPELPVHVSDHCREFLRRIF-VETKQRPSADELLRHIF 648
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: nek7 (NIMA related kinase 7 [Source:NCBI gene;Acc:101170580]) HSP 1 Score: 110.923 bits (276), Expect = 3.582e-26 Identity = 80/292 (27.40%), Postives = 137/292 (46.92%), Query Frame = 1
Query: 1354 INISNHDQMNDGDPFQGGGILFEKM--KRLENFDLGKEIARGGFGIVFHCQEKISGKNVILKK-----LIDKKLTS-FYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPI--NPISKELNELINLCLTVNPDERP 2199
+++ Q + PFQ L M L NF + K+I +G F V+ + + V LKK L+D K ++I + LN + ++D +N+ + G L+ I Q + + EK + K Q+ + +H +V+H DIKP N+ G K D GL + A S GT YY++PE ++ Y++K+DIWS G +L EM + PF+ + SL TK+++ + P+ + S+EL +L+++C+ +P++RP
Sbjct: 3 MDMQPQGQQAETPPFQPQKPLQLDMDYSSLANFQIEKKIGKGQFSEVYRARYILDNTPVALKKIQIFNLMDAKARQDCIKEIDLLKQLNHPNVIKYHASFIED---NELNIVLELADAGDLSRMINHFKNQRRLIPEKAVWKYFVQVCRALEHMHSRRVMHRDIKPANVFVTATGVVKLGDLGLGRFFSSKTTAAHSLV------GTPYYMSPERLRENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSL-CTKIQQCDYPPLPSDHYSQELRDLVDMCINPDPEKRP 284
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: nek6 (NIMA related kinase 6 [Source:NCBI gene;Acc:101173323]) HSP 1 Score: 109.768 bits (273), Expect = 8.771e-26 Identity = 86/316 (27.22%), Postives = 144/316 (45.57%), Query Frame = 1
Query: 1279 DPQNIREAKLEIARNCGASVEDFYCINISNHDQMNDGDPFQGGGILFEKMKRLENFDLGKEIARGGFGIVFHCQEKISGKNVILKK-----LIDKKLTS-FYRDIFISYHLNQAEHLVNGFEIVQDY-NDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINP--ISKELNELINLCLTVNPDERP 2199
+PQN + +E D C + DQ N G G + NF + ++I RG F V+ + ++V LKK ++D K ++I + LN N + + + D +N+ + G L+ I+ K+ + + E+ I K Q+ + + +H +V+H DIKP N+ G K D GL + A S GT YY++PE I Y++K+DIWS G +L EM + PF+ + +SL K+++ + P+ P S +L EL+++C+ PD+RP
Sbjct: 2 EPQNSHQTTVE--------NHDHLCEPVPPEDQKNPT----GCGFRCS----MANFRVERKIGRGQFSEVYRAVRLLDRQSVALKKVQIFEMMDAKARQDCIKEIDLLKQLNHP----NIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKKRRLIPERTIWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGEVKLGDLGLGRFFSSKTTAAHSLV------GTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLLSL-CRKIEQCDYPPLPPDQYSDKLRELVSMCINSEPDQRP 290
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: ENSORLT00000044704.1 (serine/threonine-protein kinase 4 [Source:NCBI gene;Acc:101175466]) HSP 1 Score: 111.309 bits (277), Expect = 2.899e-25 Identity = 74/269 (27.51%), Postives = 131/269 (48.70%), Query Frame = 1
Query: 1438 ENFDLGKEIARGGFGIVFHCQEKISGKNVILKKL-IDKKLTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINPISKELNELINLCLTVNPDERPTGEELMKSEFFKDC 2241
E FD+ +++ G +G VF K +G+ V +K++ ++ L ++I I N + H+V + + + + + M Y GS++ I + K L E+ I + + L + LH + IH DIK NI+ + EG AK D+G+A + + ++ + GT +++APEVI+ Y+ DIWS G+ +EM GKPP+ R + F+ + S+ + ++ CL NP+ R T +L++ F K
Sbjct: 31 EVFDVLEKLGEGSYGCVFKANYKETGEIVAIKQVPVESDLQEIIKEISIMQQCN-SPHVVRYYGSY--FKNSDLWIVMEYCGAGSVSDIIR---IRNKTLSEEEIATVVHSTLKGLEYLHFMRKIHRDIKAGNILLNAEGQAKLADFGVAGQL------TDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRNPDLWSENFRDFVSQCLVKNPENRATATQLLQHPFIKSA 287
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000024489.1 (SMESG000024489.1) HSP 1 Score: 878.626 bits (2269), Expect = 0.000e+0 Identity = 425/433 (98.15%), Postives = 428/433 (98.85%), Query Frame = 1
Query: 952 INEWRKIKSYFCLSLLNSSCKYFLVRSDHIENARISYNYIVINALDHFLTLLTEPDDSLKCSIKLLMNSFFLIFRSDSQLDDWMGSFNSFRSAVILTINGETHELKVQTDPQNIREAKLEIARNCGASVEDFYCINISNHDQMNDGDPFQGGGILFEKMKRLENFDLGKEIARGGFGIVFHCQEKISGKNVILKKLIDKKLTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINPISKELNELINLCLTVNPDERPTGEELMKSEFFKDCLHK 2250
INEWRKIKSYFCLSLLNSSCKYFLVRSDHIENARISYN IVINALDHFLTLLTEPD+SLKCSIKLLMNSFFLIFRSDSQLDDWMGSFN FRSAVILTINGETHELKVQTDPQNIREAKLEIA NCG SVEDFYCINISNHDQMNDGDPFQGGGILFEKMKRLENFDLGKEIARGGFGIVFHCQEKISGKN+ILKKLIDKKLTSFYRDIFISYHLNQ+EHLVNGFEIVQDY DGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINPISKELNELINLCLTVNPDERPTGEELMKSEFFKDCLHK
Sbjct: 8 INEWRKIKSYFCLSLLNSSCKYFLVRSDHIENARISYNDIVINALDHFLTLLTEPDNSLKCSIKLLMNSFFLIFRSDSQLDDWMGSFNCFRSAVILTINGETHELKVQTDPQNIREAKLEIALNCGESVEDFYCINISNHDQMNDGDPFQGGGILFEKMKRLENFDLGKEIARGGFGIVFHCQEKISGKNLILKKLIDKKLTSFYRDIFISYHLNQSEHLVNGFEIVQDYKDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINPISKELNELINLCLTVNPDERPTGEELMKSEFFKDCLHK 440
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000071997.1 (SMESG000071997.1) HSP 1 Score: 506.138 bits (1302), Expect = 1.745e-166 Identity = 301/718 (41.92%), Postives = 429/718 (59.75%), Query Frame = 1
Query: 115 MKIYVSSGSDYDGVLEIEVDEYSQGENIKYYLN*IRQEDKTWTKDYYRLIYKNIIINDHDFINKYKISDGDEIWHGKIENYLNSDDIIVEVFLAGWVPDWVWLIVKEHDSIKTIRSTLEIFQPKIIHIWNSKGDQMMDNQSVTEINREGYYQLIVRCADEREQNLTFANCCDQHD----RFR-SKFYFLRFGLYDDTQISSNVITSMQIKTKKIRQIMSTNNKIHAILDTNLSDFPYYYVNSKFLFCNHIYERIWEICEEYWELIEDPDNLSDINVCNALYVDEINEWRKIKSYFCLSLLN--SSCKYFLVRSDHIENARISYNYIVINALDHFLTLLTEPDDSLKCSIKLLMNSFFLIFRSDSQLDDWMGSFNSFRSAVILTINGETHELKVQTDPQNIREAKLEIARNCGASVEDFYCINISNHDQMNDGDPFQGGGILFEKMKRLENFDLGKEIARGGFGIVFHCQEKISGKNVILKKLIDKKLTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINPISKELNELINLCLTVNPDERPTGEELMKSEFFKDCLH 2247
MKI+V +G + IE++ + IK +R ++ ++ + N ++ND+D +++Y +SD DEIWHG +EN++ DD+IVE+FL+GW P WL+VK + S+ IR+ L +P II+I+N G M DNQ VT+I+R+GYY+LI+ C NL F C + RF+ SK + L + + I + + +IR+IMS+N+ I L+ NLSDF +++ SK LF I R+ EIC YW LI+ Y E+ W + YF LSLLN S C +V +A S+ I+I+ALD+F+ L+E + LK S KL + F LI + S+ DD S S+ + G H+L + ++P+ I EAK IA S +D Y I+ NHD+ ++ D F G I+ E M+ +E+F+ +E RG FG V QE+ISG I+KKL D K S YRD FI L+Q+ +L+ E+++ + S +LAMPYM GG+L+ +I + +C E+ I KISYQIL QIN+LH+ ++IH DIKPDNIV D GN K ID+GL+++ RL + S K PGTI Y+APE+I+ YS K DIWSFGMVLVEMVT KPPFHWA GR+++EL KM+K+KFKPI PIS+ L++ IN CLTV+P ERP+GE L+ S++ D LH
Sbjct: 1 MKIFVVNGENGGEKTAIEIEGLTFVSEIK-----LRLPEECRVNYFWLINSNNFLLNDNDHLSRYNLSDNDEIWHGSLENFIKKDDVIVEIFLSGWTPFISWLVVKVNQSMSEIRAALVRIEPDIINIFNGDGQLMEDNQLVTDIDRDGYYRLIISCGRGANMNLAFDECYKFYKLHILRFKYSKSHLLYYAQFYSEGIQEQTRYQLIYQMIRIREIMSSNDVIDTRLNKNLSDF-LFFIKSKLLFQQDISARLLEICYSYWFLIK------------YFYTSEV--WAVVGLYFRLSLLNVLSECSNSVVNLG--VSADKSFGGIIIDALDNFVLFLSEFGEILKSSAKLWTDLFSLITLAGSEFDDQFDDSYSKESSCTVKSGGRNHQLVIFSNPRTIAEAKEAIAVANKTSEQDLYVIDGQNHDEPSERDRFSQG-IIIEMMRGMEHFEFLQEKGRGAFGTVDLYQERISGNKFIIKKLNDVK-CSLYRDAFIGAKLSQS-NLLRYSEVIKGQH--SAHLAMPYMPGGTLSKHIYKG----ECQNEEDIFKISYQILAQINKLHKLEIIHRDIKPDNIVLDEGGNPKLIDFGLSRYTARLTNEDLSDKLAAYFPGTINYMAPELIRVRPYSNKIDIWSFGMVLVEMVTRKPPFHWAADGRITIELKKMQKFKFKPIMPISEGLHQFINSCLTVDPSERPSGEHLIGSQWIIDNLH 687
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000024532.1 (SMESG000024532.1) HSP 1 Score: 498.434 bits (1282), Expect = 1.248e-163 Identity = 308/709 (43.44%), Postives = 424/709 (59.80%), Query Frame = 1
Query: 115 MKIYVSSGSDYDGVLEIEVDEYSQGENIKYYLN*IRQEDKTWTKDYYRLIYKNIIINDHDFINKYKISDGDEIWHGKIENYLNSDDIIVEVFLAGWVPDWVWLIVKEHDSIKTIRSTLEIFQPKIIHIWNSKGDQMMDNQSVTEINREGYYQLIVRCADEREQNLTFANCCDQHDRFRSKFYF-LRFGLYDDTQISS-NVITSMQIKTKKIRQIMSTNNKIHAILDTNLSDFPYYYVNSKFLFCNHIYERIWEICEEYWELIEDPDNLSDINVCNALYVDEINEWRKIKSYFCLSLLNSSCKYFLVRSDHIENARISYNYIVINALDHFLTLLTEPDDSLKCSIKLLMNSFFLIFRSDSQLDDWMGSFNS--FRSAVILTINGETHELKVQTDPQNIREAKLEIARNCGASVEDFYCINISNHDQMNDGDPFQGGGILFEKMKRLENFDLGKEIARGGFGIVFHCQEKISGKNVILKKLIDKKLTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINPISKELNELINLCLTVNPDERPTGEELMKSEF 2229
MKI V +G + IE+D++S +IK+ ++ I W K++ R IYKNII++D ++I +YK+ + DEIW GKIENYL SDD+I+EVFLAG P +WLIVK + SI IRS +EI Q K+I+I++ G +M + Q V++I+ GYY+LIV DER + L+F +C QHD F +F F D T+I++ N+I KIR IMS N+ I A L NLS+ P VNSK LF +I RI +IC+E+W+ +D + N+ IKS F LS+L + +Y R EN S+N IVI+ALD+ + L + LK KL + F L+ R S+ + ++S +I + L + + +AK EIA+ G S++D YCIN NHD+ + ++ G +FE +K +EN +LGKE GGFG VF Q+ ISGK + +K K +S YRDIFIS + L + + + +AMPYM+GGSLTSYI+ K L EK ++ISYQIL QI +LHE K+IH DIKPDNIVFDG GNAK ID+GL+K ++ + K K +PGTI Y+APE+++ YSYK DIWSFGMVLVEMVTG PPFH R +EL KM +YKFKP IS EL++ I CL VNP+ERP+ ++L+ S+F
Sbjct: 1 MKISVVNGENLSVKFVIEIDKHSYVGDIKHKIDKILNGQGKWEKEHLRFIYKNIILHD-EYIKRYKVCESDEIWFGKIENYLRSDDVIIEVFLAGCSPVLIWLIVKINHSITVIRSMIEIVQSKLINIYDWNGREMQNVQIVSDIDPIGYYRLIVSYEDERGKWLSFEDCVRQHDEFTFRFCLNSEFEFEDMTEINTVNLIN-------KIRTIMSLNDVIDARLKENLSNIPSGVVNSKLLFYYNIQLRILDICQEFWKSTKDSPYYINYNI--------------IKS-FELSILVALHQYSHSRQKDPENKDKSFNGIVIDALDYLVKHLHDHCKDLKYHQKLFFDHFLLVPRPVSEYIELRNEYSSQLITKIIINKKDNIAPFLTLLLTQGTVLDAKCEIAQKLGVSIKDLYCINHWNHDKAEEDKIYKEGFYMFEIIKSMENMNLGKEFGAGGFGRVFFYQDIISGKQLAMKTANSDK-SSLYRDIFISALIMNNSELFKYSGLFK--YKSELYIAMPYMTGGSLTSYIQGK----KGLFEKEALRISYQILIQIEKLHELKIIHRDIKPDNIVFDGAGNAKLIDFGLSKWMKNSTDENILEKLKAYAPGTINYMAPEILREIPYSYKIDIWSFGMVLVEMVTGNPPFHKKAPARAIIELKKMVEYKFKPSVLISIELHQFIKSCLIVNPNERPSAQQLIGSQF 679
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000024565.1 (SMESG000024565.1) HSP 1 Score: 490.73 bits (1262), Expect = 2.305e-160 Identity = 300/735 (40.82%), Postives = 435/735 (59.18%), Query Frame = 1
Query: 115 MKIYVSSGSDYDGVLEIEVDEYSQGENIKYYLN*IRQEDKTWTKDYYRLIYKNIIINDHDFINKYKISDGDEIWHGKIENYLNSDDIIVEVFLAGWVPDWVWLIVKEHDSIKTIRSTLEIFQPKIIHIWNSKGDQMMDNQSVTEINREGYYQLIVRCADEREQNLTFANCCDQHDRFRSKFYF---LRFG-LYD---DTQISSNVITSMQIKTKKIRQIMSTNNKIHAILDTNLSDFPYYYVNSKFLFCNHIYERIWEICEEYWELIEDPDNLSDINVCNALYVDEINEWRKIKSYFCLSLLNSSCKYFLVRSDHIENARISYNYIVINALDHFLTLLTEPD------DSLKCSIKLL-----------MNSFFLIFRSDSQLDDWMGSFNSFRSAVILTINGETHELKVQTDPQNIREAKLEIARNCGASVEDFYCINISNHDQMNDGDPFQGGGILFEKMKRLENFDLGKEIARGGFGIVFHCQEKISGKNVILKKLIDKKLTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINPISKELNELINLCLTVNPDERPTGEELMKSEFFKDCLH 2247
MKI+V + + +EI+++EYS NI+ L+ I W K + +L++KNII++D I YK+ +GDEI +IENYL SDD+I+EVFL+G+VP+ ++LIV+ + SI I+S +E Q +II+I + G++M +Q+VTE + YY+LIV+ + TF +C Q+ +FR Y+ LR LY+ +T+I+ VI M +I+ IM +N+ L NLS+FP ++ +FC+ I RIW+IC++YW+L + V E +EW I +F ++LL +Y +H E A ++N IV++AL + +TLL + ++ S L+ M+ F R S+ D+ + + A + NG E +DPQ I EAK +A+ CG V D Y I N D+ DG+P+ + F M +ENFD KE A G FG VF CQ+KIS + ++LKK + + S +RDIFI Y L + L IV+D + SI LAMPY+SGGSLTS I+Q KC+ E +KISYQILTQI+ELH +++H DIKPDNI+ DG GNAK ID+GL+K +E + + K K +PGT+ Y+APE+++ YSYK DIWSFGMVLVEMVTG PPFH RV +EL KM +Y+FKP IS E N+ I CLTV+P+ERP+ ++L++S+F D L+
Sbjct: 1 MKIFVIRVENPEIKIEIKLEEYSLVRNIRNKLDKIFPGRVKWNKHFIKLVHKNIIMDDEKSIGWYKLCEGDEILCVRIENYLCSDDVILEVFLSGFVPEVIYLIVQRNYSISKIKSMIERIQCEIINICDFTGNKMTGSQTVTETSSCAYYRLIVKYGRKETCISTFEDCLKQYHKFRIIHYYDFILRLRHLYECLFETRINE-VIKQMN----EIKAIMLSNDPFEIRLKENLSEFPSAFIKCHSIFCDDISSRIWDICDDYWQLSRN--------------VIENDEWIVIGLFFRMALLIVLHQYLEHERNHCEIATKTFNSIVVDALGYSVTLLIKIRQMESFCETAGYSFDLIGELMEDICVKWMDPFLSTSRYYSEFDEVFNRYYNKTFASLKFGNGSV-EFHFHSDPQTIIEAKEAMAQKCGVKVNDLYAIYQRNEDKPTDGEPYDETILDFVLMINMENFDFLKEFATGAFGKVFICQDKISSQELVLKKSTEMEF-SLHRDIFIGYRLKNSSKLFQYSRIVKDMD--SIQLAMPYLSGGSLTSKIQQ----QKCIHENEKIKISYQILTQIHELHRLQIVHRDIKPDNIILDGAGNAKLIDFGLSKSMENVTIEILLEKLKAYAPGTVNYMAPEILREIPYSYKIDIWSFGMVLVEMVTGNPPFHKKAPPRVVIELKKMVEYEFKPNLLISIEFNQFIKWCLTVDPNERPSAQQLIESQFIIDYLN 708
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000024843.1 (SMESG000024843.1) HSP 1 Score: 451.44 bits (1160), Expect = 4.582e-147 Identity = 251/584 (42.98%), Postives = 366/584 (62.67%), Query Frame = 1
Query: 496 IWNSKGDQMMDNQSVTEINREGYYQLIVRCADEREQNLTFANCCDQHDRFRSKFYFLRFGLYDDTQISSNVITSMQIKTKKIRQIMSTNNKIHAILDTNLSDFPYYYVNSKFLFCNHIYERIWEICEEYWELIEDPDNLSDINVCNALYVDEINEWRKIKSYFCLSLLNSSCKYFLVRSDHIENARISYNYIVINALDHFLTLLTEPDDSLKCSIKLLMNSFFLIFRSDSQLDDWMGSFNSFRSAVILTINGETHELKVQTDPQNIREAKLEIARNCGASVEDFYCINISNHDQMNDGDPFQGGGILFEKMKRLENFDLGKEIARGGFGIVFHCQEKISGKNVILKKLIDKKLTSFYRDIFISYHLNQAEHLVNGFEIVQDYNDGSINLAMPYMSGGSLTSYIEQCLKQWKCLQEKHIVKISYQILTQINELHECKVIHCDIKPDNIVFDGEGNAKCIDYGLAKHVERLEGKAQSRKRKESSPGTIYYLAPEVIKGELYSYKTDIWSFGMVLVEMVTGKPPFHWAGIGRVSLELTKMKKYKFKPINPISKELNELINLCLTVNPDERPTGEELMKSEFFKDCLH 2247
+W+ KG++M +NQSVT+I+ GYY+LIV C E + NLTF CC+QHDR + Y+ ++ + S + + KKIRQI+S+N+ I L+ NLS FP +V +LF + I +RIW+IC EY +L++ + C +EW +K +F +LL + KY + +N + S+N I+++ALD + L P + K + K +NSFFLI +SD +D+ F+ S +I+ I E +E+ V+ +P+ I EA +A +D Y IN D+ NDGDP+ FE M ++ +F+ E+A GGFG VF C++KISGK V++KKLID K S +R+I I L E L+ E+++D + +I+L MPY+ GG+LTS I+Q KCL E +++IS+QILTQI+ELH+ K+IHCDIKP+NIVFD E N K ID+GLAK++ K SRKRK SSPGTI Y+APE+ K + S K DIWSFGMV+VEMVTG+ PF+ G G++ L L K+ KY+FKP+ IS +L + I+ CLTV+P+ RPT ++L++S+ + L
Sbjct: 1 MWDCKGNEMQNNQSVTDIDAFGYYRLIVNCGQEADDNLTFDECCNQHDRCKIILYYYSENWWEFEKFSEIARVKIINQIKKIRQIISSNDTIDPRLNENLSHFPKAFVKQNYLFGHDITKRIWDICNEYRKLMKSYP--FSVQFCLN------DEWHAMKLFFLTALLVTMRKYSDAVQNDPKNTKKSFNDILVDALDCLVRHLMNPCEDWKHAAKRWLNSFFLITQSDGDMDELFVKFDP--SMIIVRIKSEEYEMDVELNPKTILEATKAVANKFRIDRQDLYSINHWIPDKPNDGDPYFQPMTFFELMSKMADFENLNELANGGFGKVFICEDKISGKQVVMKKLIDVK-DSLHREILIGSILFDKE-LIKYSEVIRD--EKNIHLTMPYLPGGTLTSNIQQL----KCLGENEVIRISHQILTQISELHKSKIIHCDIKPENIVFDNERNVKLIDFGLAKYIGDFRSKDLSRKRKASSPGTINYMAPELTKEDPNSVKIDIWSFGMVMVEMVTGQLPFNVMGPGQILLRLGKLLKYEFKPMMEISNDLKQFISWCLTVDPNVRPTAQQLIESQLINNYLQ 566 The following BLAST results are available for this feature:
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30032093 ID=SMED30032093|Name=Protein kinase domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=3118bpback to top protein sequence of SMED30032093-orf-1 >SMED30032093-orf-1 ID=SMED30032093-orf-1|Name=SMED30032093-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=578bp MMDNQSVTEINREGYYQLIVRCADEREQNLTFANCCDQHDRFRSKFYFLRback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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