Prosaposin

Overview
NameProsaposin
Smed IDSMED30031903
Length (bp)1124
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Prosaposin (SMED30031903) t-SNE clustered cells

Violin plots show distribution of expression levels for Prosaposin (SMED30031903) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Prosaposin (SMED30031903) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Prosaposin (SMED30031903) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30031903

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 8

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
gutSMED30031903SMESG000019973.1 Contig692newmark_estsPMID:23079596
Forsthoefel et al., 2012		whole organism asexual adult colorimetric in situ hybridization evidence
intestinal phagocyteSMED30031903SMESG000019973.1 Contig692newmark_estsPMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
gutSMED30031903SMESG000068491.1 Contig692newmark_estsPMID:23079596
Forsthoefel et al., 2012		whole organism asexual adult colorimetric in situ hybridization evidence
intestinal phagocyteSMED30031903SMESG000068491.1 Contig692newmark_estsPMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
nervous systemSMED30031903SMESG000019973.1 dd_Smed_v4_2944_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neuronSMED30031903SMESG000019973.1 dd_Smed_v4_2944_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		whole organism asexual adult colorimetric in situ hybridization evidence
parenchymal cellSMED30031903SMESG000019973.1 dd_Smed_v4_2944_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30031903SMESG000019973.1 dd_Smed_v4_2944_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Prosaposin vs. Ensembl Human
Match: PSAP (prosaposin [Source:HGNC Symbol;Acc:HGNC:9498])

HSP 1 Score: 62.3882 bits (150), Expect = 1.494e-10
Identity = 33/76 (43.42%), Postives = 46/76 (60.53%), Query Frame = 3 
Query:  534 CLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSS 761
            C +CK+++ YLD  L+K STK+EIL AL K CS LP    KQC  F+ +Y   +++ LV+   P  VC  +  C S
Sbjct:  125 CEVCKKLVGYLDRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKIGACPS 200
[Close]
BLAST of Prosaposin vs. Ensembl Human
Match: PSAP (prosaposin [Source:HGNC Symbol;Acc:HGNC:9498])

HSP 1 Score: 62.3882 bits (150), Expect = 5.670e-10
Identity = 33/76 (43.42%), Postives = 46/76 (60.53%), Query Frame = 3 
Query:  534 CLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSS 761
            C +CK+++ YLD  L+K STK+EIL AL K CS LP    KQC  F+ +Y   +++ LV+   P  VC  +  C S
Sbjct:  412 CEVCKKLVGYLDRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKIGACPS 487
[Close]
BLAST of Prosaposin vs. Ensembl Human
Match: PSAP (prosaposin [Source:HGNC Symbol;Acc:HGNC:9498])

HSP 1 Score: 62.3882 bits (150), Expect = 6.012e-10
Identity = 33/76 (43.42%), Postives = 46/76 (60.53%), Query Frame = 3 
Query:  534 CLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSS 761
            C +CK+++ YLD  L+K STK+EIL AL K CS LP    KQC  F+ +Y   +++ LV+   P  VC  +  C S
Sbjct:  409 CEVCKKLVGYLDRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKIGACPS 484
[Close]
BLAST of Prosaposin vs. Ensembl Human
Match: PSAPL1 (prosaposin like 1 (gene/pseudogene) [Source:HGNC Symbol;Acc:HGNC:33131])

HSP 1 Score: 55.8398 bits (133), Expect = 7.324e-8
Identity = 28/97 (28.87%), Postives = 53/97 (54.64%), Query Frame = 3 
Query:  528 LECLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSSKDTVP--EDTMYFIPKSTY 812
            + C +C  +++ LD  L   S++  I  AL +VCS++PA+ +K+C++ +D Y+  ++  LV    PE VC F+ +C ++       D    +P   +
Sbjct:  292 VTCEVCMNVVQKLDHWLMSNSSELMITHALERVCSVMPASITKECIILVDTYSPSLVQ-LVAKITPEKVCKFIRLCGNRRRARAVHDAYAIVPSPEW 387
[Close]
BLAST of Prosaposin vs. Ensembl Fly
Match: Sap-r (gene:FBgn0000416 transcript:FBtr0085714)

HSP 1 Score: 62.7734 bits (151), Expect = 2.646e-10
Identity = 34/84 (40.48%), Postives = 50/84 (59.52%), Query Frame = 3 
Query:  510 SKVNNPLECLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSS 761
            S +  P  C+LC+ I+  LD  LK ++ +++I  A+  VC+ LPA   KQC  F+D YAS ++  L D  PP+ VC  L +C S
Sbjct:  692 SSIKEPPTCVLCEFIMTKLDADLKNKTEQDDIKRAIEAVCNRLPATVRKQCDTFVDGYASAVLKLLSDV-PPKQVCQKLQLCFS 774

HSP 2 Score: 55.0694 bits (131), Expect = 6.515e-8
Identity = 28/96 (29.17%), Postives = 46/96 (47.92%), Query Frame = 3 
Query:  534 CLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSSKDTVPEDTMYFIPKSTYGNQ 821
            C LC+ ++ ++ E L   ST +EI   +  +C+ LP+  + QC  F++ Y   ++  LV G  P  VC  + +C       ED   F P+     Q
Sbjct:  360 CTLCEYMLHFIQETLATPSTDDEIKHTVENICAKLPSGVAGQCRNFVEMYGDAVIALLVQGLNPRDVCPLMQMCPKNLPKKEDVEVFNPQPASDEQ 455
[Close]
BLAST of Prosaposin vs. Ensembl Fly
Match: Sap-r (gene:FBgn0000416 transcript:FBtr0085713)

HSP 1 Score: 62.7734 bits (151), Expect = 2.691e-10
Identity = 34/84 (40.48%), Postives = 50/84 (59.52%), Query Frame = 3 
Query:  510 SKVNNPLECLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSS 761
            S +  P  C+LC+ I+  LD  LK ++ +++I  A+  VC+ LPA   KQC  F+D YAS ++  L D  PP+ VC  L +C S
Sbjct:  769 SSIKEPPTCVLCEFIMTKLDADLKNKTEQDDIKRAIEAVCNRLPATVRKQCDTFVDGYASAVLKLLSD-VPPKQVCQKLQLCFS 851

HSP 2 Score: 55.0694 bits (131), Expect = 6.840e-8
Identity = 28/96 (29.17%), Postives = 46/96 (47.92%), Query Frame = 3 
Query:  534 CLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSSKDTVPEDTMYFIPKSTYGNQ 821
            C LC+ ++ ++ E L   ST +EI   +  +C+ LP+  + QC  F++ Y   ++  LV G  P  VC  + +C       ED   F P+     Q
Sbjct:  437 CTLCEYMLHFIQETLATPSTDDEIKHTVENICAKLPSGVAGQCRNFVEMYGDAVIALLVQGLNPRDVCPLMQMCPKNLPKKEDVEVFNPQPASDEQ 532
[Close]
BLAST of Prosaposin vs. Ensembl Zebrafish
Match: psap (prosaposin [Source:ZFIN;Acc:ZDB-GENE-020108-1])

HSP 1 Score: 67.3958 bits (163), Expect = 1.156e-12
Identity = 34/104 (32.69%), Postives = 62/104 (59.62%), Query Frame = 3 
Query:  471 VSVGKNNGLITAKS--KVNNPLECLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSSKDTVP 776
            V V K    + AK+  +V +  +C +C+ ++K ++ +++ ++++ EI+ A+ KVC++LP+  + QC   I+ Y   I+D LV    P+ VC FL +CS    VP
Sbjct:   51 VKVEKPVATMPAKNLVRVRDSPQCAICEYVMKEIENMIQDQTSEAEIVQAVEKVCNILPSTLTAQCKDLIETYGQAIIDLLVQEADPKTVCSFLALCSGVSHVP 154
[Close]
BLAST of Prosaposin vs. Ensembl Zebrafish
Match: psap (prosaposin [Source:ZFIN;Acc:ZDB-GENE-020108-1])

HSP 1 Score: 67.0106 bits (162), Expect = 1.030e-11
Identity = 34/104 (32.69%), Postives = 62/104 (59.62%), Query Frame = 3 
Query:  471 VSVGKNNGLITAKS--KVNNPLECLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSSKDTVP 776
            V V K    + AK+  +V +  +C +C+ ++K ++ +++ ++++ EI+ A+ KVC++LP+  + QC   I+ Y   I+D LV    P+ VC FL +CS    VP
Sbjct:  291 VKVEKPVATMPAKNLVRVRDSPQCAICEYVMKEIENMIQDQTSEAEIVQAVEKVCNILPSTLTAQCKDLIETYGQAIIDLLVQEADPKTVCSFLALCSGVSHVP 394
[Close]
BLAST of Prosaposin vs. Ensembl Zebrafish
Match: psap (prosaposin [Source:ZFIN;Acc:ZDB-GENE-020108-1])

HSP 1 Score: 67.0106 bits (162), Expect = 1.164e-11
Identity = 34/104 (32.69%), Postives = 62/104 (59.62%), Query Frame = 3 
Query:  471 VSVGKNNGLITAKS--KVNNPLECLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSSKDTVP 776
            V V K    + AK+  +V +  +C +C+ ++K ++ +++ ++++ EI+ A+ KVC++LP+  + QC   I+ Y   I+D LV    P+ VC FL +CS    VP
Sbjct:  289 VKVEKPVATMPAKNLVRVRDSPQCAICEYVMKEIENMIQDQTSEAEIVQAVEKVCNILPSTLTAQCKDLIETYGQAIIDLLVQEADPKTVCSFLALCSGVSHVP 392
[Close]
BLAST of Prosaposin vs. Ensembl Zebrafish
Match: sftpbb (surfactant protein Bb [Source:NCBI gene;Acc:100001978])

HSP 1 Score: 48.9062 bits (115), Expect = 4.701e-6
Identity = 26/78 (33.33%), Postives = 41/78 (52.56%), Query Frame = 3 
Query:  522 NPLECLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVC 755
            NP+ C  C   IK ++ +L KE T+  I   L K+C  LP +    C  F+  YA ++++ L+   PP  +C  L +C
Sbjct:  149 NPI-CNFCLLFIKTVESLLPKEKTEAAIEELLEKICGYLPEHYEDTCNTFVKTYAKQLIELLLYSMPPHAICTALGLC 225
[Close]
BLAST of Prosaposin vs. Ensembl Xenopus
Match: psap (prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy) [Source:NCBI gene;Acc:550039])

HSP 1 Score: 53.9138 bits (128), Expect = 2.721e-7
Identity = 32/95 (33.68%), Postives = 51/95 (53.68%), Query Frame = 3 
Query:  495 LITAKSKVNNPLE-----CLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSSK 764
            LI A     NPL      C +C+ +I  ++++L    TKE I  +L KVC LLPA  S++C   I++Y   +++ L     P+ +C  L  CS++
Sbjct:  249 LIPAAKITENPLAGNGVFCEVCQLMISQIEKLLDNNRTKENIKHSLEKVCKLLPAEYSQKCEDIIEEYYDPLIELLEQEANPQFICTTLGYCSAR 343

HSP 2 Score: 50.8322 bits (120), Expect = 2.209e-6
Identity = 24/77 (31.17%), Postives = 46/77 (59.74%), Query Frame = 3 
Query:  534 CLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSSK 764
            C +CK ++KY+DE+L+K +T+  I   L++VC+ LP +   +C   +++Y    +  L++   P  +C  L +C S+
Sbjct:  372 CTVCKMMMKYVDELLEKNATEIRIKNFLSRVCNFLPDSMQDECSGLVNQYEPLFVQLLLEALDPSFICAKLHLCQSE 448
[Close]
BLAST of Prosaposin vs. Ensembl Xenopus
Match: psap (prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy) [Source:NCBI gene;Acc:550039])

HSP 1 Score: 53.5286 bits (127), Expect = 2.901e-7
Identity = 29/89 (32.58%), Postives = 49/89 (55.06%), Query Frame = 3 
Query:  498 ITAKSKVNNPLECLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSSK 764
            IT      N + C +C+ +I  ++++L    TKE I  +L KVC LLPA  S++C   I++Y   +++ L     P+ +C  L  CS++
Sbjct:  233 ITENPLAGNGVFCEVCQLMISQIEKLLDNNRTKENIKHSLEKVCKLLPAEYSQKCEDIIEEYYDPLIELLEQEANPQFICTTLGYCSAR 321
[Close]
BLAST of Prosaposin vs. Ensembl Xenopus
Match: psap (prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy) [Source:NCBI gene;Acc:550039])

HSP 1 Score: 53.5286 bits (127), Expect = 3.365e-7
Identity = 29/89 (32.58%), Postives = 49/89 (55.06%), Query Frame = 3 
Query:  498 ITAKSKVNNPLECLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSSK 764
            IT      N + C +C+ +I  ++++L    TKE I  +L KVC LLPA  S++C   I++Y   +++ L     P+ +C  L  CS++
Sbjct:  239 ITENPLAGNGVFCEVCQLMISQIEKLLDNNRTKENIKHSLEKVCKLLPAEYSQKCEDIIEEYYDPLIELLEQEANPQFICTTLGYCSAR 327

HSP 2 Score: 50.8322 bits (120), Expect = 2.337e-6
Identity = 24/77 (31.17%), Postives = 46/77 (59.74%), Query Frame = 3 
Query:  534 CLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSSK 764
            C +CK ++KY+DE+L+K +T+  I   L++VC+ LP +   +C   +++Y    +  L++   P  +C  L +C S+
Sbjct:  347 CTVCKMMMKYVDELLEKNATEIRIKNFLSRVCNFLPDSMQDECSGLVNQYEPLFVQLLLEALDPSFICAKLHLCQSE 423
[Close]
BLAST of Prosaposin vs. Ensembl Xenopus
Match: psap (prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy) [Source:NCBI gene;Acc:550039])

HSP 1 Score: 53.5286 bits (127), Expect = 3.451e-7
Identity = 29/89 (32.58%), Postives = 49/89 (55.06%), Query Frame = 3 
Query:  498 ITAKSKVNNPLECLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSSK 764
            IT      N + C +C+ +I  ++++L    TKE I  +L KVC LLPA  S++C   I++Y   +++ L     P+ +C  L  CS++
Sbjct:  263 ITENPLAGNGVFCEVCQLMISQIEKLLDNNRTKENIKHSLEKVCKLLPAEYSQKCEDIIEEYYDPLIELLEQEANPQFICTTLGYCSAR 351

HSP 2 Score: 50.8322 bits (120), Expect = 2.226e-6
Identity = 24/77 (31.17%), Postives = 46/77 (59.74%), Query Frame = 3 
Query:  534 CLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSSK 764
            C +CK ++KY+DE+L+K +T+  I   L++VC+ LP +   +C   +++Y    +  L++   P  +C  L +C S+
Sbjct:  371 CTVCKMMMKYVDELLEKNATEIRIKNFLSRVCNFLPDSMQDECSGLVNQYEPLFVQLLLEALDPSFICAKLHLCQSE 447
[Close]
BLAST of Prosaposin vs. Ensembl Xenopus
Match: psap (prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy) [Source:NCBI gene;Acc:550039])

HSP 1 Score: 53.5286 bits (127), Expect = 3.789e-7
Identity = 34/113 (30.09%), Postives = 57/113 (50.44%), Query Frame = 3 
Query:  495 LITAKSKVNNPLE-----CLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSSKDTVPEDTMYFIPKSTYGN 818
            LI A     NPL      C +C+ +I  ++++L    TKE I  +L KVC LLPA  S++C   I++Y   +++ L     P+ +C  L  CS++    ++      K+  G+
Sbjct:  248 LIPAAKITENPLAGNGVFCEVCQLMISQIEKLLDNNRTKENIKHSLEKVCKLLPAEYSQKCEDIIEEYYDPLIELLEQEANPQFICTTLGYCSARRKNLQNVKISAEKAAAGD 360

HSP 2 Score: 50.8322 bits (120), Expect = 2.828e-6
Identity = 24/77 (31.17%), Postives = 46/77 (59.74%), Query Frame = 3 
Query:  534 CLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSSK 764
            C +CK ++KY+DE+L+K +T+  I   L++VC+ LP +   +C   +++Y    +  L++   P  +C  L +C S+
Sbjct:  362 CTVCKMMMKYVDELLEKNATEIRIKNFLSRVCNFLPDSMQDECSGLVNQYEPLFVQLLLEALDPSFICAKLHLCQSE 438
[Close]
BLAST of Prosaposin vs. Ensembl Mouse
Match: Psap (prosaposin [Source:MGI Symbol;Acc:MGI:97783])

HSP 1 Score: 62.3882 bits (150), Expect = 3.354e-10
Identity = 34/76 (44.74%), Postives = 47/76 (61.84%), Query Frame = 3 
Query:  534 CLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSS 761
            C +CK+++ YL+  L+K STKEEIL AL K CS LP    KQC  F+ +Y   +++ LV+   P  VC  + VC S
Sbjct:  436 CEVCKKLVLYLEHNLEKNSTKEEILAALEKGCSFLPDPYQKQCDDFVAEYEPLLLEILVEVMDPGFVCSKIGVCPS 511
[Close]
BLAST of Prosaposin vs. Ensembl Mouse
Match: Psap (prosaposin [Source:MGI Symbol;Acc:MGI:97783])

HSP 1 Score: 62.3882 bits (150), Expect = 3.437e-10
Identity = 34/76 (44.74%), Postives = 47/76 (61.84%), Query Frame = 3 
Query:  534 CLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSS 761
            C +CK+++ YL+  L+K STKEEIL AL K CS LP    KQC  F+ +Y   +++ LV+   P  VC  + VC S
Sbjct:  442 CEVCKKLVLYLEHNLEKNSTKEEILAALEKGCSFLPDPYQKQCDDFVAEYEPLLLEILVEVMDPGFVCSKIGVCPS 517
[Close]
BLAST of Prosaposin vs. Ensembl Mouse
Match: Psap (prosaposin [Source:MGI Symbol;Acc:MGI:97783])

HSP 1 Score: 62.3882 bits (150), Expect = 3.562e-10
Identity = 34/76 (44.74%), Postives = 47/76 (61.84%), Query Frame = 3 
Query:  534 CLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSS 761
            C +CK+++ YL+  L+K STKEEIL AL K CS LP    KQC  F+ +Y   +++ LV+   P  VC  + VC S
Sbjct:  442 CEVCKKLVLYLEHNLEKNSTKEEILAALEKGCSFLPDPYQKQCDDFVAEYEPLLLEILVEVMDPGFVCSKIGVCPS 517
[Close]
BLAST of Prosaposin vs. Ensembl Mouse
Match: Psap (prosaposin [Source:MGI Symbol;Acc:MGI:97783])

HSP 1 Score: 62.3882 bits (150), Expect = 3.614e-10
Identity = 34/76 (44.74%), Postives = 47/76 (61.84%), Query Frame = 3 
Query:  534 CLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSS 761
            C +CK+++ YL+  L+K STKEEIL AL K CS LP    KQC  F+ +Y   +++ LV+   P  VC  + VC S
Sbjct:  439 CEVCKKLVLYLEHNLEKNSTKEEILAALEKGCSFLPDPYQKQCDDFVAEYEPLLLEILVEVMDPGFVCSKIGVCPS 514
[Close]
BLAST of Prosaposin vs. Ensembl Mouse
Match: Psap (prosaposin [Source:MGI Symbol;Acc:MGI:97783])

HSP 1 Score: 62.3882 bits (150), Expect = 3.622e-10
Identity = 34/76 (44.74%), Postives = 47/76 (61.84%), Query Frame = 3 
Query:  534 CLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSS 761
            C +CK+++ YL+  L+K STKEEIL AL K CS LP    KQC  F+ +Y   +++ LV+   P  VC  + VC S
Sbjct:  441 CEVCKKLVLYLEHNLEKNSTKEEILAALEKGCSFLPDPYQKQCDDFVAEYEPLLLEILVEVMDPGFVCSKIGVCPS 516
[Close]
BLAST of Prosaposin vs. UniProt/SwissProt
Match: sp|P26779|SAP_BOVIN (Prosaposin OS=Bos taurus OX=9913 GN=PSAP PE=1 SV=3)

HSP 1 Score: 72.4034 bits (176), Expect = 1.365e-12
Identity = 36/94 (38.30%), Postives = 59/94 (62.77%), Query Frame = 3 
Query:  534 CLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSSKDTVPEDTMYFIPKSTYG 815
            C +C+ ++K + +++    T+EEIL AL+KVCS LP + ++QC   +D Y S I+  L+D   PE+VC  L +CSS+  +P  T+  +P+   G
Sbjct:  316 CEVCEFVVKEVAKLIDNNRTEEEILHALDKVCSKLPTSLAEQCQEVVDTYGSSILSILLDEASPELVCSMLHLCSSRG-LPAATVRVMPRKDGG 408

HSP 2 Score: 62.003 bits (149), Expect = 3.160e-9
Identity = 49/171 (28.65%), Postives = 85/171 (49.71%), Query Frame = 3 
Query:  249 QFICKRIAMFLGHDLDTSKSPEQLKKLFLPTCNMFRSHLKNICXXXXXXXXXXXXXXXXXXXXXXXVCKKRLLRVSVGKNNGLITAKSKVNNPLECLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSS 761
            +F+ K +A  +    D +++ E++       C+   + L   C++  +  G  I+  L+ + +P+ VC    L  S G     +    + +    C +CK+++ YLD  L+K STKE+IL AL K CS LP    KQC  F+ +Y   +++ LV+   P  VC  +  C +
Sbjct:  320 EFVVKEVAKLI----DNNRTEEEILHALDKVCSKLPTSLAEQCQEVVDTYGSSILSILLDEASPELVCSMLHLCSSRGLPAATVRVMPRKDGGF-CEVCKKLVGYLDRNLEKNSTKEQILAALEKGCSFLPDQYRKQCDQFVTEYEPVLIEILVEVMDPSFVCLKIGACPA 485
[Close]
BLAST of Prosaposin vs. UniProt/SwissProt
Match: sp|P10960|SAP_RAT (Prosaposin OS=Rattus norvegicus OX=10116 GN=Psap PE=1 SV=1)

HSP 1 Score: 63.1586 bits (152), Expect = 1.693e-9
Identity = 34/76 (44.74%), Postives = 47/76 (61.84%), Query Frame = 3 
Query:  534 CLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSS 761
            C +CK+++ YL+  L+K STKEEIL AL K CS LP    KQC  F+ +Y   +++ LV+   P  VC  + VC S
Sbjct:  439 CEVCKKLVIYLEHNLEKNSTKEEILAALEKGCSFLPDPYQKQCDEFVAEYEPLLLEILVEVMDPSFVCSKIGVCPS 514
[Close]
BLAST of Prosaposin vs. UniProt/SwissProt
Match: sp|Q61207|SAP_MOUSE (Prosaposin OS=Mus musculus OX=10090 GN=Psap PE=1 SV=2)

HSP 1 Score: 62.3882 bits (150), Expect = 2.405e-9
Identity = 34/76 (44.74%), Postives = 47/76 (61.84%), Query Frame = 3 
Query:  534 CLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSS 761
            C +CK+++ YL+  L+K STKEEIL AL K CS LP    KQC  F+ +Y   +++ LV+   P  VC  + VC S
Sbjct:  442 CEVCKKLVLYLEHNLEKNSTKEEILAALEKGCSFLPDPYQKQCDDFVAEYEPLLLEILVEVMDPGFVCSKIGVCPS 517
[Close]
BLAST of Prosaposin vs. UniProt/SwissProt
Match: sp|P07602|SAP_HUMAN (Prosaposin OS=Homo sapiens OX=9606 GN=PSAP PE=1 SV=2)

HSP 1 Score: 62.3882 bits (150), Expect = 2.887e-9
Identity = 33/76 (43.42%), Postives = 46/76 (60.53%), Query Frame = 3 
Query:  534 CLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSS 761
            C +CK+++ YLD  L+K STK+EIL AL K CS LP    KQC  F+ +Y   +++ LV+   P  VC  +  C S
Sbjct:  409 CEVCKKLVGYLDRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKIGACPS 484
[Close]
BLAST of Prosaposin vs. UniProt/SwissProt
Match: sp|O13035|SAP_CHICK (Prosaposin OS=Gallus gallus OX=9031 GN=PSAP PE=1 SV=1)

HSP 1 Score: 59.6918 bits (143), Expect = 2.049e-8
Identity = 34/91 (37.36%), Postives = 49/91 (53.85%), Query Frame = 3 
Query:  534 CLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSS--KDTVPEDTMYFIP 800
            C +CK I+ Y D+ L+K +T  EI   L KVC  LP + S QCV F+++Y   ++  L +   P  VC  L VC +  K  + ED   + P
Sbjct:  403 CDICKMIVAYADKELEKNATTTEIEALLEKVCHFLPESVSDQCVQFVEQYEPVVVQLLAEMMDPTFVCTKLGVCGAAKKPLLGEDACVWGP 493

HSP 2 Score: 57.3806 bits (137), Expect = 1.127e-7
Identity = 29/93 (31.18%), Postives = 51/93 (54.84%), Query Frame = 3 
Query:  534 CLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSSKDTVPEDTMYFIPKSTY 812
            C +C+ ++K +  +L+   T+EEI+  +  VC LLPA+   QC  FI+ Y   ++D L++   PE VC  +L C + +  P+  +   P   +
Sbjct:  311 CEICETMVKEVTGLLESNKTEEEIVHEMEVVCYLLPASVKDQCKDFIEVYGQALIDMLLEATNPEAVC-VMLKCCAANKPPQQPVVVKPAGGF 402
[Close]
BLAST of Prosaposin vs. TrEMBL
Match: A0A224Z8B0 (Saposin OS=Rhipicephalus zambeziensis OX=60191 PE=4 SV=1)

HSP 1 Score: 80.1073 bits (196), Expect = 1.017e-12
Identity = 48/169 (28.40%), Postives = 91/169 (53.85%), Query Frame = 3 
Query:  255 ICKRIAMFLGHDLDTSKSPEQLKKLFLPTCNMFRSHLKNICXXXXXXXXXXXXXXXXXXXXXXXVCKKRLLRVSVGKNNGLITAKSKVNNPLECLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSS 761
            ICK +  F+  +L  +K+ E++KKL    C++    LK  C         ++++ +++   P++VC +  L  S  K   + T  +KV N  EC  C  I++Y+ + L+ E T+EEI  AL++VC+L   ++ ++CV  ++ Y   I+  ++    P+ +C  + +C S
Sbjct:   19 ICKVVVKFVYDELQDNKTEEEVKKLLDKVCSVLPESLKQTCTDTVNTYYDQLVQLIIQGFTPEEVCAELSLCTSASKKKPVATRPAKVANDEECTYCTTIVQYVYDALQDEKTEEEIKEALDEVCNLFHGDRRQKCVNMVNTYFEIIVSLILQDFTPQQICETIGLCPS 187
[Close]
BLAST of Prosaposin vs. TrEMBL
Match: A0A3M6TM61 (Uncharacterized protein OS=Pocillopora damicornis OX=46731 GN=pdam_00020424 PE=4 SV=1)

HSP 1 Score: 75.485 bits (184), Expect = 2.728e-11
Identity = 41/110 (37.27%), Postives = 63/110 (57.27%), Query Frame = 3 
Query:  477 VGKNNGLITAKSKVNNPLECLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSSKDTVPEDTMYFIPKS 806
              K+  ++     V    EC+LC+ I+  LD ILK+ +T+EEI  AL+KVCS LP++ S +C  FI++Y+  I+  L     P+ VC  L +C+S+    E     +PKS
Sbjct:  165 AAKHKPVVVKSKPVKTSAECILCEFIMDKLDSILKQNATREEIEEALDKVCSYLPSSISSECTQFINQYSDAILQILAQELDPKEVCTALQLCTSQAKAMEKPKIHLPKS 274
[Close]
BLAST of Prosaposin vs. TrEMBL
Match: A0A4W2DSD5 (Prosaposin OS=Bos indicus x Bos taurus OX=30522 GN=PSAP PE=4 SV=1)

HSP 1 Score: 73.1738 bits (178), Expect = 2.244e-10
Identity = 36/94 (38.30%), Postives = 59/94 (62.77%), Query Frame = 3 
Query:  534 CLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSSKDTVPEDTMYFIPKSTYG 815
            C +C+ ++K + +++    T+EEIL AL+KVCS LP + ++QC   +D Y S I+  L+D   PE+VC  L +CSS+  +P  T+  +P+   G
Sbjct:  365 CEVCEFVVKEVAKLIDNNRTEEEILHALDKVCSKLPTSLAEQCQEVVDTYGSSILSILLDEASPELVCSMLHLCSSRG-LPAATVRVMPRKDGG 457
[Close]
BLAST of Prosaposin vs. TrEMBL
Match: A0A4W2EBR5 (Prosaposin OS=Bos indicus x Bos taurus OX=30522 GN=PSAP PE=4 SV=1)

HSP 1 Score: 73.1738 bits (178), Expect = 2.836e-10
Identity = 36/94 (38.30%), Postives = 59/94 (62.77%), Query Frame = 3 
Query:  534 CLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSSKDTVPEDTMYFIPKSTYG 815
            C +C+ ++K + +++    T+EEIL AL+KVCS LP + ++QC   +D Y S I+  L+D   PE+VC  L +CSS+  +P  T+  +P+   G
Sbjct:  365 CEVCEFVVKEVAKLIDNNRTEEEILHALDKVCSKLPTSLAEQCQEVVDTYGSSILSILLDEASPELVCSMLHLCSSRG-LPAATVRVMPRKDGG 457

HSP 2 Score: 62.3882 bits (150), Expect = 7.589e-7
Identity = 32/76 (42.11%), Postives = 46/76 (60.53%), Query Frame = 3 
Query:  534 CLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSS 761
            C +CK+++ YLD  L+K STKE+IL AL K CS LP    KQC  F+ +Y   +++ LV+   P  VC  +  C +
Sbjct:  459 CEVCKKLVGYLDRNLEKNSTKEQILAALEKGCSFLPDQYRKQCDQFVTEYEPVLIEILVEVMDPSFVCLKIGACPA 534
[Close]
BLAST of Prosaposin vs. TrEMBL
Match: A0A131XQS9 (Putative saposin (Fragment) OS=Hyalomma excavatum OX=257692 PE=2 SV=1)

HSP 1 Score: 73.1738 bits (178), Expect = 3.252e-10
Identity = 46/169 (27.22%), Postives = 90/169 (53.25%), Query Frame = 3 
Query:  255 ICKRIAMFLGHDLDTSKSPEQLKKLFLPTCNMFRSHLKNICXXXXXXXXXXXXXXXXXXXXXXXVCKKRLLRVSVGKNNGLITAKSKVNNPLECLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSS 761
            ICK +  F+ ++L  +K+ E++K L    CN+    LK  C         ++++ +++   P++VC++  L  SV +        +KV N  EC  C  I++Y+ + L+ E T+EEI   L++VC+L   ++ +QC+  ++ Y   I+  ++    P+ +C  + +C S
Sbjct:  814 ICKVVVKFVYNELQDNKTEEEVKNLLDKVCNLLPDSLKQTCTDTVNTYYDQLVQLIVQGFTPEQVCQELGLCPSVLRKPA-AARPAKVANDEECTYCTTIVQYVYDALQDEKTEEEIKEVLDEVCNLFHGDRRQQCINMVNTYFEIIVALVLQDFTPQQICQTIGMCPS 981

HSP 2 Score: 65.0846 bits (157), Expect = 1.428e-7
Identity = 47/171 (27.49%), Postives = 88/171 (51.46%), Query Frame = 3 
Query:  255 ICKRIAMFLGHDLDTSKSPEQLKKLFLPTCNMFRSHLKNICXXXXXXXXXXXXXXXXXXXXXXXVCKKRLLRVSVGKNNGLITAKSKVNNPL--ECLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSS 761
            ICK +  F+ ++L  +K+ E++K +    C +    LK  C         ++++ +++  +P++VC++  L  S  K      A      P   EC +CK ++K++   L+   T+EE+   L+KVC+LLP +  + C   ++ Y  +++  +V G  PE VC  L +C S
Sbjct:  717 ICKVVVKFVYNELQDNKTEEEVKNVLDKVCALLPDSLKQTCINTVNTYYDQLVELIVQGFSPEQVCQELGLCPSGRKAMMPAVANVPSKKPADEECDICKVVVKFVYNELQDNKTEEEVKNLLDKVCNLLPDSLKQTCTDTVNTYYDQLVQLIVQGFTPEQVCQELGLCPS 887

HSP 3 Score: 62.3882 bits (150), Expect = 1.086e-6
Identity = 46/171 (26.90%), Postives = 88/171 (51.46%), Query Frame = 3 
Query:  255 ICKRIAMFLGHDLDTSKSPEQLKKLFLPTCNMFRSHLKNICXXXXXXXXXXXXXXXXXXXXXXXVCKKRLLRVSVGKNNGLITAKSKVNNPL--ECLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSS 761
            +C  +A F+   +   ++ E++K+     C++  S L+  C +        ++  L+++ +P +VCK+  L  S  K      A      P   EC +CK ++K++   L+   T+EE+   L+KVC+LLP +  + C+  ++ Y  ++++ +V G  PE VC  L +C S
Sbjct:  620 LCMVVAKFVYDKVKDERTEEKVKEALDQVCSLLPSSLEQKCVEMVNNYYDMLVNLLLQELDPDQVCKELGLCPSTKKAKMPPVASVPPKKPTDEECDICKVVVKFVYNELQDNKTEEEVKNVLDKVCALLPDSLKQTCINTVNTYYDQLVELIVQGFSPEQVCQELGLCPS 790
[Close]
BLAST of Prosaposin vs. Ensembl Cavefish
Match: psap (prosaposin [Source:ZFIN;Acc:ZDB-GENE-020108-1])

HSP 1 Score: 63.929 bits (154), Expect = 8.487e-11
Identity = 27/89 (30.34%), Postives = 54/89 (60.67%), Query Frame = 3 
Query:  513 KVNNPLECLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSSKDTVPE 779
            +   P +C +C+ ++K L+++++ ++T+EE++ A+ KVC++LP+  + QC   I+ Y   I++ LV    P+ +C  L +C     V E
Sbjct:  294 RAREPPQCAICEYVMKELEDMIQDQTTEEEVMQAVEKVCNILPSTLTAQCKDLIETYGQAIIELLVQEADPKTICTVLGLCKGASPVME 382

HSP 2 Score: 48.9062 bits (115), Expect = 5.718e-6
Identity = 28/80 (35.00%), Postives = 46/80 (57.50%), Query Frame = 3 
Query:  534 CLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLP-ANKSKQCVLFIDKYASKIMDFL-VDGNPPEMVCHFLLVCSSKD 767
            C LCKE++  +D++LK  ST+ EIL  + K C L+P  N + +C   +D Y   +M  +  +   P +VC  L +C S++
Sbjct:   61 CDLCKEVLVVVDQLLKDNSTEAEILGYMEKTCQLIPDENLAAECKELVDNYYPILMGIIKGELEDPSVVCGALGLCVSQE 140
[Close]
BLAST of Prosaposin vs. Ensembl Cavefish
Match: psap (prosaposin [Source:ZFIN;Acc:ZDB-GENE-020108-1])

HSP 1 Score: 63.1586 bits (152), Expect = 1.631e-10
Identity = 27/90 (30.00%), Postives = 57/90 (63.33%), Query Frame = 3 
Query:  513 KVNNPLECLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVC--SSKDTVP 776
            +   P +C +C+ ++K L+++++ ++T+EE++ A+ KVC++LP+  + QC   I+ Y   I++ LV    P+ +C  L +C  +S+  +P
Sbjct:  294 RAREPPQCAICEYVMKELEDMIQDQTTEEEVMQAVEKVCNILPSTLTAQCKDLIETYGQAIIELLVQEADPKTICTVLGLCKGASRAFIP 383

HSP 2 Score: 48.9062 bits (115), Expect = 6.195e-6
Identity = 28/80 (35.00%), Postives = 46/80 (57.50%), Query Frame = 3 
Query:  534 CLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLP-ANKSKQCVLFIDKYASKIMDFL-VDGNPPEMVCHFLLVCSSKD 767
            C LCKE++  +D++LK  ST+ EIL  + K C L+P  N + +C   +D Y   +M  +  +   P +VC  L +C S++
Sbjct:   61 CDLCKEVLVVVDQLLKDNSTEAEILGYMEKTCQLIPDENLAAECKELVDNYYPILMGIIKGELEDPSVVCGALGLCVSQE 140
[Close]
BLAST of Prosaposin vs. Ensembl Cavefish
Match: sftpbb (surfactant protein Bb [Source:NCBI gene;Acc:100001978])

HSP 1 Score: 55.8398 bits (133), Expect = 7.488e-9
Identity = 35/105 (33.33%), Postives = 54/105 (51.43%), Query Frame = 3 
Query:  459 RLLRVSVGKNNGLITAKSKVNNPLE------CLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVC 755
             +L VS+ + +G I A+       E      C  C  II+ L+ +L KE T  EI+ AL  +C+ LP +   QC  F++ Y  +I+DFL+    P  +C  L +C
Sbjct:   42 EMLHVSL-EADGFIQAQPSTQTSPEVQITPQCTFCLFIIRKLENMLPKERT--EIVKALETICNHLPDHYKDQCNSFLETYGKQILDFLLTSATPHTICALLHLC 143
[Close]
BLAST of Prosaposin vs. Ensembl Nematostella
Match: EDO31455 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SXX5])

HSP 1 Score: 66.6254 bits (161), Expect = 4.718e-12
Identity = 31/91 (34.07%), Postives = 58/91 (63.74%), Query Frame = 3 
Query:  495 LITAKSKVNNPLECLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSSKD 767
            ++ A   V    EC+LC+ ++K LD++L K ST++EI+ A+ KVCS+LP+    +C  F+ +Y   +++ L     P++VC  L +C++++
Sbjct:  229 VLKATYPVKTSTECVLCEFVMKELDDMLSKNSTQQEIIQAVEKVCSILPSTIKSKCDQFVQEYGPALIEILEQEVSPKLVCTTLGLCANRE 319

HSP 2 Score: 52.373 bits (124), Expect = 1.580e-7
Identity = 27/109 (24.77%), Postives = 57/109 (52.29%), Query Frame = 3 
Query:  447 VCKKRLLRVSVGKNNGLITAKSKVNNPLECLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSSKDTV 773
            +C  R  R+++ +++ L+   ++      C +C  ++ YL   L   +T EEI+  L KVC+ LP+  + +C   + +Y S ++  + + +P  + C  + +CS+   V
Sbjct:  314 LCANREHRIAMRRSHKLVIGSNET-----CEICTTVMTYLKAFLNNNATDEEIVNFLEKVCNYLPSQIASECNAIVSEYGSTVLQIIANTDPTTL-CKEIGLCSANQHV 416
[Close]
BLAST of Prosaposin vs. Ensembl Nematostella
Match: EDO38309 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SDD7])

HSP 1 Score: 60.077 bits (144), Expect = 4.014e-10
Identity = 29/76 (38.16%), Postives = 49/76 (64.47%), Query Frame = 3 
Query:  534 CLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSS 761
            C++C+ +++ L ++L + STKEEI  ALNK+CS +P +   +C  F+ +Y   I++ L     PE+VC  L +CS+
Sbjct:  199 CVMCEFVMRELSKMLNENSTKEEIETALNKLCSYMPGSIQSECKTFVQEYTPFIIEILSKEFKPELVCRELKLCSA 274
[Close]
BLAST of Prosaposin vs. Ensembl Nematostella
Match: EDO39178 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SAT7])

HSP 1 Score: 51.6026 bits (122), Expect = 2.360e-7
Identity = 29/94 (30.85%), Postives = 53/94 (56.38%), Query Frame = 3 
Query:  492 GLITAKSKV----NNPLECLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSS 761
            GL +A   V    ++  +C+LC+ ++K + ++L K++T++ I  AL  VCS++P      C  F+ +Y   IM  L++   P  VC  + +C+S
Sbjct:  269 GLCSADRWVCPRPDDAPQCVLCEFVMKEIKQLLAKDTTQQGIEKALMMVCSIMPETIRNNCDKFVTEYTPIIMSLLLEEVDPAKVCSMIGLCNS 362
[Close]
BLAST of Prosaposin vs. Ensembl Medaka
Match: sftpbb (prosaposin-like [Source:NCBI gene;Acc:101161410])

HSP 1 Score: 60.8474 bits (146), Expect = 6.238e-10
Identity = 33/94 (35.11%), Postives = 55/94 (58.51%), Query Frame = 3 
Query:  501 TAKSKVNNPLECLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSSKDT-VPE 779
            T   K++ P+ C LC  +I+ L+ +L K  +++ IL  + +VC L+PA+  +QC  F++KY + I +FL     P  +C  L +C  K+  VPE
Sbjct:  143 TETQKISGPV-CALCLMVIRKLETMLPKNISEDAILKIMEEVCDLVPASYKQQCDDFVNKYGADIAEFLFSSAAPHTICMVLHLCLFKEQPVPE 235
[Close]
BLAST of Prosaposin vs. Ensembl Medaka
Match: sftpbb (prosaposin-like [Source:NCBI gene;Acc:101161410])

HSP 1 Score: 60.8474 bits (146), Expect = 6.305e-10
Identity = 33/94 (35.11%), Postives = 55/94 (58.51%), Query Frame = 3 
Query:  501 TAKSKVNNPLECLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSSKDT-VPE 779
            T   K++ P+ C LC  +I+ L+ +L K  +++ IL  + +VC L+PA+  +QC  F++KY + I +FL     P  +C  L +C  K+  VPE
Sbjct:  119 TETQKISGPV-CALCLMVIRKLETMLPKNISEDAILKIMEEVCDLVPASYKQQCDDFVNKYGADIAEFLFSSAAPHTICMVLHLCLFKEQPVPE 211
[Close]
BLAST of Prosaposin vs. Ensembl Medaka
Match: psap (prosaposin [Source:NCBI gene;Acc:101163196])

HSP 1 Score: 60.077 bits (144), Expect = 1.587e-9
Identity = 27/82 (32.93%), Postives = 51/82 (62.20%), Query Frame = 3 
Query:  513 KVNNPLECLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCS 758
            +V    +C +C+ ++K ++ +L  E+T+EE++ A+ KVC L+P++ + QC   I+ Y   I++ LV    P+ VC  L +C+
Sbjct:  315 RVKESPQCAICEFVMKQVEAMLTDETTEEEVIQAVQKVCYLVPSSLTAQCKDLIETYGEAIIELLVQEVDPKTVCTMLALCN 396
[Close]
BLAST of Prosaposin vs. Planmine SMEST
Match: SMESG000019973.1 (SMESG000019973.1)

HSP 1 Score: 470.7 bits (1210), Expect = 2.812e-168
Identity = 258/261 (98.85%), Postives = 261/261 (100.00%), Query Frame = 3 
Query:   42 MNAVILSVSIIIFHLSLSYTESSFSTLPIKNVQNIKKALCEMFPKSLKVECYTKPDKSDDKEFYIPHQHQFICKRIAMFLGHDLDTSKSPEQLKKLFLPTCNMFRSHLKNICXXXXXXXXXXXXXXXXXXXXXXXVCKKRLLRVSVGKNNGLITAKSKVNNPLECLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSSKDTVPEDTMYFIPKSTYGNQH 824
            MNAVILSVSIIIFHLSLSYTESSFSTLPIKNVQNIKKALCEMFPKSLKVECYT+PDKSDDKEFYIPHQHQFICKRIAMFLGHDLDTSKSPEQLKKLFLPTCNMFRSHL+NICKKFTEEEGKKIIKKL+KKENPKKVCKKRLLRVSVGKNNGLITAKSKVNNPLECLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSSKDTVPEDTMYFIPKSTYGNQH
Sbjct:    1 MNAVILSVSIIIFHLSLSYTESSFSTLPIKNVQNIKKALCEMFPKSLKVECYTEPDKSDDKEFYIPHQHQFICKRIAMFLGHDLDTSKSPEQLKKLFLPTCNMFRSHLRNICKKFTEEEGKKIIKKLLKKENPKKVCKKRLLRVSVGKNNGLITAKSKVNNPLECLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSSKDTVPEDTMYFIPKSTYGNQH 261
[Close]
BLAST of Prosaposin vs. Planmine SMEST
Match: SMESG000019975.1 (SMESG000019975.1)

HSP 1 Score: 67.781 bits (164), Expect = 1.128e-12
Identity = 59/242 (24.38%), Postives = 118/242 (48.76%), Query Frame = 3 
Query:  147 KKALCEMFPKSLKVECY----TKPDKSDDKEFYIPHQHQF------------ICKRIAMFLGHDLDTSKSPEQLKKLFLPTCNMFRSHLKNICXXXXXXXXXXXXXXXXXXXXXXXVCKKRLLRVSVGKNNGLITAKSKVNNPLE----CLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSSKD--TV-PEDTMYFIPK 803
            KK LC +FP++ + +C     TKP    + E +   + +             +CK++   +   + ++ S + ++K     C+      K +CK   ++    I+ +++K     K+C+          N GL ++ + ++ P E    C +C +II+ + + + +    EEI  AL  VC++ P     QC  F+D+YA +I+  +++G    ++C  L +C +++  T+  +DTMYF+PK
Sbjct:   30 KKLLCTLFPETFREKCSEYSPTKPIGISEIEIHAQIKIKMTNSEENKSFGCDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQ----------NIGLCSSLAAISPPREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYPTIKSKDTMYFLPK 261
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BLAST of Prosaposin vs. Planmine SMEST
Match: SMESG000019976.1 (SMESG000019976.1)

HSP 1 Score: 49.2914 bits (116), Expect = 6.700e-7
Identity = 30/107 (28.04%), Postives = 53/107 (49.53%), Query Frame = 3 
Query:  501 TAKSKVNNPLECLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSSKDTV------PEDTMYFIPK 803
            T  ++ N  L C +CK+II+ + +  K + ++  IL AL KVC  LP      C   +  +  KI++ ++   P + +C  +  C S +         E+ +YF+PK
Sbjct:   69 TTNTEENKSLRCDICKKIIERVIKETKNKHSRYAILKALEKVCDELPEVMKSSCKYAVQNFGDKIVNDIMKNVPAKKICEDIGFCDSGEIERAPKIKTEEALYFLPK 175
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BLAST of Prosaposin vs. Planmine SMEST
Match: SMESG000020046.1 (SMESG000020046.1)

HSP 1 Score: 48.9062 bits (115), Expect = 2.666e-6
Identity = 62/268 (23.13%), Postives = 124/268 (46.27%), Query Frame = 3 
Query:   51 VILSVSIIIFHLSLSYTESSFSTLPIKNVQNIKKALCEMFPKSLKVECYT----------------KPDKSDDKE-FYIPHQHQFICKRIAMFLGHDLDTSKSPEQLKKLFLPTCNMFRSHLKNICXXXXXXXXXXXXXXXXXXXXXXXVCKKRLLRVSVGKNNGLITAKSKVNNPLE-CLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSSKDTVPEDTMYFIP 800
            ++  + I++   SLS  +  F     +N   + + +C + PK+ +++C +                  + S DKE  + P +  F C      L   ++TS + +Q++   L  C +  S  K     F ++EG K+I +++KK+ P K+C+   +     K   +     KV NP + C +C+ +   L  + K + +KE+I   +   CS  P  ++ +C  F+  +  KI+ F++  +    +C  L +CS++     DT++ +P
Sbjct:    3 LLFGIIILLVLNSLSLCDDEF-----QNANKVSETICRLLPKAFQLQCSSLLHENNNKHIKVHAQLDLEMSKDKESRWKPKRKCFKCIAFVYMLERFINTSLTSDQVQNHLLDLCQIISSPKKEKIIDFLKKEGPKLIPRILKKDCPIKICQ---MENFCHKIEVIFENDDKVPNPSKYCSICQSVSNQLGSLRKLKLSKEKINQVVGTACSFGPTAQANECKAFLSIFQDKIISFMITEDKTVSLCESLRLCSTQKK-SSDTLFGLP 261
The following BLAST results are available for this feature:
BLAST of Prosaposin vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 4
Match NameE-valueIdentityDescription
PSAP1.494e-1043.42prosaposin [Source:HGNC Symbol;Acc:HGNC:9498][more]
PSAP5.670e-1043.42prosaposin [Source:HGNC Symbol;Acc:HGNC:9498][more]
PSAP6.012e-1043.42prosaposin [Source:HGNC Symbol;Acc:HGNC:9498][more]
PSAPL17.324e-828.87prosaposin like 1 (gene/pseudogene) [Source:HGNC S... [more]
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BLAST of Prosaposin vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Prosaposin vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Sap-r2.646e-1040.48gene:FBgn0000416 transcript:FBtr0085714[more]
Sap-r2.691e-1040.48gene:FBgn0000416 transcript:FBtr0085713[more]
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BLAST of Prosaposin vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 4
Match NameE-valueIdentityDescription
psap1.156e-1232.69prosaposin [Source:ZFIN;Acc:ZDB-GENE-020108-1][more]
psap1.030e-1132.69prosaposin [Source:ZFIN;Acc:ZDB-GENE-020108-1][more]
psap1.164e-1132.69prosaposin [Source:ZFIN;Acc:ZDB-GENE-020108-1][more]
sftpbb4.701e-633.33surfactant protein Bb [Source:NCBI gene;Acc:100001... [more]
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BLAST of Prosaposin vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
psap2.721e-733.68prosaposin (variant Gaucher disease and variant me... [more]
psap2.901e-732.58prosaposin (variant Gaucher disease and variant me... [more]
psap3.365e-732.58prosaposin (variant Gaucher disease and variant me... [more]
psap3.451e-732.58prosaposin (variant Gaucher disease and variant me... [more]
psap3.789e-730.09prosaposin (variant Gaucher disease and variant me... [more]
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BLAST of Prosaposin vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Psap3.354e-1044.74prosaposin [Source:MGI Symbol;Acc:MGI:97783][more]
Psap3.437e-1044.74prosaposin [Source:MGI Symbol;Acc:MGI:97783][more]
Psap3.562e-1044.74prosaposin [Source:MGI Symbol;Acc:MGI:97783][more]
Psap3.614e-1044.74prosaposin [Source:MGI Symbol;Acc:MGI:97783][more]
Psap3.622e-1044.74prosaposin [Source:MGI Symbol;Acc:MGI:97783][more]
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BLAST of Prosaposin vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P26779|SAP_BOVIN1.365e-1238.30Prosaposin OS=Bos taurus OX=9913 GN=PSAP PE=1 SV=3[more]
sp|P10960|SAP_RAT1.693e-944.74Prosaposin OS=Rattus norvegicus OX=10116 GN=Psap P... [more]
sp|Q61207|SAP_MOUSE2.405e-944.74Prosaposin OS=Mus musculus OX=10090 GN=Psap PE=1 S... [more]
sp|P07602|SAP_HUMAN2.887e-943.42Prosaposin OS=Homo sapiens OX=9606 GN=PSAP PE=1 SV... [more]
sp|O13035|SAP_CHICK2.049e-837.36Prosaposin OS=Gallus gallus OX=9031 GN=PSAP PE=1 S... [more]
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BLAST of Prosaposin vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A224Z8B01.017e-1228.40Saposin OS=Rhipicephalus zambeziensis OX=60191 PE=... [more]
A0A3M6TM612.728e-1137.27Uncharacterized protein OS=Pocillopora damicornis ... [more]
A0A4W2DSD52.244e-1038.30Prosaposin OS=Bos indicus x Bos taurus OX=30522 GN... [more]
A0A4W2EBR52.836e-1038.30Prosaposin OS=Bos indicus x Bos taurus OX=30522 GN... [more]
A0A131XQS93.252e-1027.22Putative saposin (Fragment) OS=Hyalomma excavatum ... [more]
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BLAST of Prosaposin vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 3
Match NameE-valueIdentityDescription
psap8.487e-1130.34prosaposin [Source:ZFIN;Acc:ZDB-GENE-020108-1][more]
psap1.631e-1030.00prosaposin [Source:ZFIN;Acc:ZDB-GENE-020108-1][more]
sftpbb7.488e-933.33surfactant protein Bb [Source:NCBI gene;Acc:100001... [more]
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BLAST of Prosaposin vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Prosaposin vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Prosaposin vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3
Match NameE-valueIdentityDescription
EDO314554.718e-1234.07Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO383094.014e-1038.16Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO391782.360e-730.85Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Prosaposin vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 3
Match NameE-valueIdentityDescription
sftpbb6.238e-1035.11prosaposin-like [Source:NCBI gene;Acc:101161410][more]
sftpbb6.305e-1035.11prosaposin-like [Source:NCBI gene;Acc:101161410][more]
psap1.587e-932.93prosaposin [Source:NCBI gene;Acc:101163196][more]
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BLAST of Prosaposin vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 4
Match NameE-valueIdentityDescription
SMESG000019973.12.812e-16898.85SMESG000019973.1[more]
SMESG000019975.11.128e-1224.38SMESG000019975.1[more]
SMESG000019976.16.700e-728.04SMESG000019976.1[more]
SMESG000020046.12.666e-623.13SMESG000020046.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30031903 ID=SMED30031903|Name=Prosaposin|organism=Schmidtea mediterranea sexual|type=transcript|length=1124bp
AAATACTAAATATAAATTTTTTCTTGTTTGTAAATTAATCAATGAACGCT
GTTATATTATCTGTTTCTATCATAATTTTTCATCTGTCTCTCTCATATAC
TGAAAGCTCCTTTAGCACTCTCCCAATCAAAAATGTACAAAACATCAAGA
AAGCATTGTGTGAAATGTTTCCAAAGTCCTTGAAAGTTGAATGTTACACA
AAACCTGATAAAAGCGATGACAAAGAATTTTATATTCCACATCAACATCA
ATTCATTTGCAAGCGAATAGCTATGTTTCTCGGCCACGACCTTGATACTT
CAAAGTCCCCGGAACAACTTAAAAAACTATTCTTGCCTACCTGTAACATG
TTCAGATCGCATTTAAAGAACATTTGTAAGAAATTTACCGAAGAAGAAGG
CAAAAAAATTATTAAAAAGTTAATGAAAAAAGAAAATCCTAAAAAGGTTT
GTAAGAAAAGACTGCTTCGAGTATCAGTTGGAAAAAATAACGGTCTTATT
ACGGCAAAAAGTAAGGTTAATAATCCGTTGGAGTGCCTATTGTGTAAGGA
AATCATTAAATATCTCGATGAAATTCTTAAGAAAGAGTCAACAAAAGAAG
AAATATTATTAGCGCTAAACAAAGTTTGCTCATTGTTGCCAGCAAATAAA
TCGAAACAATGTGTTTTGTTTATCGATAAATATGCTAGTAAAATAATGGA
TTTCCTAGTGGATGGCAATCCGCCTGAAATGGTGTGCCATTTTCTATTGG
TCTGTTCTAGTAAAGATACGGTGCCAGAGGATACTATGTATTTTATTCCA
AAATCCACTTATGGAAATCAGCACTAAATCTAGGAAACATTTCTGATTTA
CAATTTTTCTCATAATTCATTCAACTTTCCCCATAAAATTCAATAGTTTC
CACATATCTGTTTCGCTGTTATAAAATATATAATCAATTAATTGCTTGTT
CCAATAATATTACAGTATAGCAGCAGTATACAGATGACTTTCGATTAGGG
GACGTCCATTAATTATGTCAATAAATTAGTGTAGGAGGGTTTGACAAATG
TTGACATGGGGAGGGGGAGTTAAAAAAAATTGATGTCAACAAGGAAACTC
AGCTGAGCTCTTGATGTTAACGAA
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protein sequence of SMED30031903-orf-1

>SMED30031903-orf-1 ID=SMED30031903-orf-1|Name=SMED30031903-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=262bp
MNAVILSVSIIIFHLSLSYTESSFSTLPIKNVQNIKKALCEMFPKSLKVE
CYTKPDKSDDKEFYIPHQHQFICKRIAMFLGHDLDTSKSPEQLKKLFLPT
CNMFRSHLKNICKKFTEEEGKKIIKKLMKKENPKKVCKKRLLRVSVGKNN
GLITAKSKVNNPLECLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLP
ANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSSKDTVPEDTMY
FIPKSTYGNQH*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: biological process
TermDefinition
GO:0001865NK T cell differentiation
GO:0003335corneocyte development
GO:0006643membrane lipid metabolic process
GO:0006664glycolipid metabolic process
GO:0006672ceramide metabolic process
GO:0006678glucosylceramide metabolic process
GO:0006683galactosylceramide catabolic process
GO:0006886intracellular protein transport
GO:0007041lysosomal transport
GO:0007605sensory perception of sound
GO:0009306protein secretion
GO:0010467gene expression
GO:0019882antigen processing and presentation
GO:0021702cerebellar Purkinje cell differentiation
GO:0042552myelination
GO:0043408regulation of MAPK cascade
GO:0043410positive regulation of MAPK cascade
GO:0048589developmental growth
GO:0050877neurological system process
GO:0050885neuromuscular process controlling balance
GO:0051345positive regulation of hydrolase activity
GO:0060073micturition
GO:0070841inclusion body assembly
GO:0071310cellular response to organic substance
GO:0090102cochlea development
GO:0090659walking behavior
GO:1903206negative regulation of hydrogen peroxide-induced cell death
GO:1903575cornified envelope assembly
GO:1905146lysosomal protein catabolic process
GO:1905572ganglioside GM1 transport to membrane
GO:0006665sphingolipid metabolic process
GO:0006629lipid metabolic process
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0019216regulation of lipid metabolic process
GO:0043085positive regulation of catalytic activity
GO:0060736prostate gland growth
GO:0060742epithelial cell differentiation involved in prostate gland development
Vocabulary: molecular function
TermDefinition
GO:0002020protease binding
GO:0004565beta-galactosidase activity
GO:0005543phospholipid binding
GO:0030882lipid antigen binding
GO:0042802identical protein binding
GO:0042803protein homodimerization activity
GO:1905573ganglioside GM1 binding
GO:1905574ganglioside GM2 binding
GO:1905575ganglioside GM3 binding
GO:1905576ganglioside GT1b binding
GO:1905577ganglioside GP1c binding
GO:0001664G-protein coupled receptor binding
GO:0008047enzyme activator activity
Vocabulary: cellular component
TermDefinition
GO:0005770late endosome
GO:0016235aggresome
GO:0043231intracellular membrane-bounded organelle
GO:0005764lysosome
GO:0005576extracellular region
GO:0005615extracellular space
GO:0005737cytoplasm
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0000070intestinal phagocyte
PLANA:0000099neuron
PLANA:0000101muscle cell
PLANA:0003001lateral region of the whole animal
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR007856SapB_1
IPR011001Saposin-like
IPR008373Saposin
IPR008139SaposinB_dom
IPR008138SapB_2