Periplasmic serine endoprotease DegP

Overview
NamePeriplasmic serine endoprotease DegP
Smed IDSMED30031874
Length (bp)1143
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Periplasmic serine endoprotease DegP (SMED30031874) t-SNE clustered cells

Violin plots show distribution of expression levels for Periplasmic serine endoprotease DegP (SMED30031874) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Periplasmic serine endoprotease DegP (SMED30031874) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Periplasmic serine endoprotease DegP (SMED30031874) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30031874

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 6

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X2 cellSMED30031874 SmedASXL_067144SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
nervous systemSMED30031874 dd_Smed_v4_12272_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30031874 dd_Smed_v4_12272_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30031874 dd_Smed_v4_12272_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30031874 dd_Smed_v4_12272_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cilated neuronSMED30031874 dd_Smed_v4_12272_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Periplasmic serine endoprotease DegP vs. Ensembl Human
Match: HTRA1 (HtrA serine peptidase 1 [Source:HGNC Symbol;Acc:HGNC:9476])

HSP 1 Score: 52.7582 bits (125), Expect = 5.369e-7
Identity = 46/146 (31.51%), Postives = 73/146 (50.00%), Query Frame = 3 
Query:  411 SGFIVDHTGLILTVGIDLEKCDSVTIKTQDGRTFPVNLIEYDTSTGLCLLKILYQSPLFLSALNLSDVKDVYCRTGDFVVSLGASSNSNFSQFSLGILQTNYAGD------SFSNNYILSE-ITNQTCLLPGGPVINLHGKVVGIN 827
            SGFIV   GLI+T    +     V ++ ++G T+   + + D    + L+KI +Q  L +  L  S       R G+FVV++G S  S  +  + GI+ T   G       +   +YI ++ I N      GGP++NL G+V+GIN
Sbjct:   99 SGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSS----ELRPGEFVVAIG-SPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGN--SGGPLVNLDGEVIGIN 237
[Close]
BLAST of Periplasmic serine endoprotease DegP vs. Ensembl Human
Match: HTRA1 (HtrA serine peptidase 1 [Source:HGNC Symbol;Acc:HGNC:9476])

HSP 1 Score: 51.6026 bits (122), Expect = 1.345e-6
Identity = 46/146 (31.51%), Postives = 73/146 (50.00%), Query Frame = 3 
Query:  411 SGFIVDHTGLILTVGIDLEKCDSVTIKTQDGRTFPVNLIEYDTSTGLCLLKILYQSPLFLSALNLSDVKDVYCRTGDFVVSLGASSNSNFSQFSLGILQTNYAGD------SFSNNYILSE-ITNQTCLLPGGPVINLHGKVVGIN 827
            SGFIV   GLI+T    +     V ++ ++G T+   + + D    + L+KI +Q  L +  L  S       R G+FVV++G S  S  +  + GI+ T   G       +   +YI ++ I N      GGP++NL G+V+GIN
Sbjct:  205 SGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSS----ELRPGEFVVAIG-SPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYG--NSGGPLVNLDGEVIGIN 343
[Close]
BLAST of Periplasmic serine endoprotease DegP vs. Ensembl Fly
Match: HtrA2 (gene:FBgn0038233 transcript:FBtr0082987)

HSP 1 Score: 59.6918 bits (143), Expect = 1.694e-9
Identity = 57/185 (30.81%), Postives = 90/185 (48.65%), Query Frame = 3 
Query:  411 SGFIVDHTGLILT-VGIDLEKCDS-VTIKTQDGRTFPVNLIEYDTSTGLCLLKILYQSPLFLSALNLSDVKDVYCRTGDFVVSLGA-------------SSNSNFSQFSLGI-------LQTNYAGDSFSNNYILSEITNQTCLLPGGPVINLHGKVVGINASNSDLEKSCQVIPVELGRLLLER 899
            SGFI++  GLILT   + + K  + V ++  DGRTFP  + + D ++ L  L+I   +   LS + L   K    R+G++VV+LG+             SS    SQ  LG+       LQT+ A  +F N+              GGP++NL G+ +G+N+       S   IP++  ++ LER
Sbjct:  142 SGFIIEQNGLILTNAHVVINKPHTMVQVRLSDGRTFPATIEDVDQTSDLATLRIQVNN---LSVMRLG--KSSTLRSGEWVVALGSPLALSNTVTAGVISSTQRASQ-ELGLRNRDINYLQTD-AAITFGNS--------------GGPLVNLDGEAIGVNSMKVTAGISF-AIPIDYVKVFLER 304
[Close]
BLAST of Periplasmic serine endoprotease DegP vs. Ensembl Fly
Match: HtrA2 (gene:FBgn0038233 transcript:FBtr0330045)

HSP 1 Score: 59.6918 bits (143), Expect = 1.694e-9
Identity = 57/185 (30.81%), Postives = 90/185 (48.65%), Query Frame = 3 
Query:  411 SGFIVDHTGLILT-VGIDLEKCDS-VTIKTQDGRTFPVNLIEYDTSTGLCLLKILYQSPLFLSALNLSDVKDVYCRTGDFVVSLGA-------------SSNSNFSQFSLGI-------LQTNYAGDSFSNNYILSEITNQTCLLPGGPVINLHGKVVGINASNSDLEKSCQVIPVELGRLLLER 899
            SGFI++  GLILT   + + K  + V ++  DGRTFP  + + D ++ L  L+I   +   LS + L   K    R+G++VV+LG+             SS    SQ  LG+       LQT+ A  +F N+              GGP++NL G+ +G+N+       S   IP++  ++ LER
Sbjct:  142 SGFIIEQNGLILTNAHVVINKPHTMVQVRLSDGRTFPATIEDVDQTSDLATLRIQVNN---LSVMRLG--KSSTLRSGEWVVALGSPLALSNTVTAGVISSTQRASQ-ELGLRNRDINYLQTD-AAITFGNS--------------GGPLVNLDGEAIGVNSMKVTAGISF-AIPIDYVKVFLER 304
[Close]
BLAST of Periplasmic serine endoprotease DegP vs. Ensembl Zebrafish
Match: si:dkey-33c12.12 (si:dkey-33c12.12 [Source:ZFIN;Acc:ZDB-GENE-081028-30])

HSP 1 Score: 58.5362 bits (140), Expect = 5.130e-9
Identity = 62/200 (31.00%), Postives = 90/200 (45.00%), Query Frame = 3 
Query:  411 SGFIVDHTGLILTVGIDLEKCDSVTIKTQDGRTFPVNLIEYDTSTGLCLLKILYQSPLFLSALNLSDVKDVYCRTGDFVVSLGASSNSNFSQFSL------GILQTNYAGDS---FSNNYILSEITNQTCLL--PGGPVINLHGKVVGINASNSDLEKSCQVIPVELGRLLLERNKTEINDAVSRVFSCEEKSSSFGCDG 977
            SGFIV   GLI+T    +     V +K  +G T+   + + D +  +  +KI  ++P  L  L L    DV  R G+FVV++G       S FSL      GI+ +   G      SN+ +    T+ T      GGP+INL G+V+GIN        S   IP +  RL L+R             S +++ S FG  G
Sbjct:  160 SGFIVSSDGLIVTNAHVVANKRGVRVKLTNGETYNATVQDVDQAADIATIKINVKNP--LPTLRLGKSSDV--RQGEFVVAMG-------SPFSLKNTITSGIVSSAQRGSKELGLSNSNMDYIQTDATIDFGNSGGPLINLDGEVIGINTMKVTAGISF-AIPSDRVRLFLDR-------------SADKQKSWFGESG 334
[Close]
BLAST of Periplasmic serine endoprotease DegP vs. Ensembl Zebrafish
Match: si:dkey-33c12.12 (si:dkey-33c12.12 [Source:ZFIN;Acc:ZDB-GENE-081028-30])

HSP 1 Score: 58.5362 bits (140), Expect = 5.130e-9
Identity = 62/200 (31.00%), Postives = 90/200 (45.00%), Query Frame = 3 
Query:  411 SGFIVDHTGLILTVGIDLEKCDSVTIKTQDGRTFPVNLIEYDTSTGLCLLKILYQSPLFLSALNLSDVKDVYCRTGDFVVSLGASSNSNFSQFSL------GILQTNYAGDS---FSNNYILSEITNQTCLL--PGGPVINLHGKVVGINASNSDLEKSCQVIPVELGRLLLERNKTEINDAVSRVFSCEEKSSSFGCDG 977
            SGFIV   GLI+T    +     V +K  +G T+   + + D +  +  +KI  ++P  L  L L    DV  R G+FVV++G       S FSL      GI+ +   G      SN+ +    T+ T      GGP+INL G+V+GIN        S   IP +  RL L+R             S +++ S FG  G
Sbjct:  160 SGFIVSSDGLIVTNAHVVANKRGVRVKLTNGETYNATVQDVDQAADIATIKINVKNP--LPTLRLGKSSDV--RQGEFVVAMG-------SPFSLKNTITSGIVSSAQRGSKELGLSNSNMDYIQTDATIDFGNSGGPLINLDGEVIGINTMKVTAGISF-AIPSDRVRLFLDR-------------SADKQKSWFGESG 334
[Close]
BLAST of Periplasmic serine endoprotease DegP vs. Ensembl Zebrafish
Match: zgc:174193 (zgc:174193 [Source:ZFIN;Acc:ZDB-GENE-080215-8])

HSP 1 Score: 54.6842 bits (130), Expect = 6.087e-8
Identity = 59/200 (29.50%), Postives = 90/200 (45.00%), Query Frame = 3 
Query:  411 SGFIVDHTGLILTVGIDLEKCDSVTIKTQDGRTFPVNLIEYDTSTGLCLLKILYQSPLFLSALNLSDVKDVYCRTGDFVVSLGASSNSNFSQFSL------GILQTNYAGD---SFSNNYILSEITNQTCLL--PGGPVINLHGKVVGINASNSDLEKSCQVIPVELGRLLLERNKTEINDAVSRVFSCEEKSSSFGCDG 977
            SGFI+   GLI+T    +     V +K  +G T+   + + D +  +  +KI  ++P  L  L L    DV  R G+FVV++G       S FSL      GI+ +   G      SN+ +    T+ T      GGP+I+L G+V+ IN        S   IP +  RL L+R             S ++++S FG  G
Sbjct:   16 SGFIISSDGLIVTNAHAVANKRGVRVKLTNGETYNATVQDVDQAADIATIKINVKNP--LPTLRLGKSSDV--RQGEFVVAMG-------SPFSLKNTITSGIVSSAQRGSKELGLSNSNMDYIQTDATIDFGNSGGPLIHLDGEVISINTMKVTAGISF-AIPSDRVRLFLDR-------------SADKQNSWFGESG 190
[Close]
BLAST of Periplasmic serine endoprotease DegP vs. Ensembl Zebrafish
Match: htra1b (HtrA serine peptidase 1b [Source:NCBI gene;Acc:565082])

HSP 1 Score: 54.6842 bits (130), Expect = 1.057e-7
Identity = 51/162 (31.48%), Postives = 80/162 (49.38%), Query Frame = 3 
Query:  378 LIKNNVINNE-----QSGFIVDHTGLILTVGIDLEKCDSVTIKTQDGRTFPVNLIEYDTSTGLCLLKILYQSPLFLSALNLSDVKDVYCRTGDFVVSLGASSNSNFSQFSLGILQTNYAGD------SFSNNYILSE-ITNQTCLLPGGPVINLHGKVVGIN 827
            L + NV N E      SGF+V   GLI+T    +     V ++ + G T+   + + D    + L+KI   +P+ L  L L    D+  R G+FVV++G S  S  +  + GI+ T   G       +   +YI ++ I N      GGP++NL G+V+GIN
Sbjct:  185 LFRKNVFNREVAVASGSGFVVSEDGLIVTNAHVVANKHRVKVELKTGTTYDAKIKDVDEKADIALIKI--DAPMKLPVLLLGRSADL--RPGEFVVAIG-SPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYG--NSGGPLVNLDGEVIGIN 339
[Close]
BLAST of Periplasmic serine endoprotease DegP vs. Ensembl Zebrafish
Match: si:dkey-33c12.12 (si:dkey-33c12.12 [Source:ZFIN;Acc:ZDB-GENE-081028-30])

HSP 1 Score: 48.1358 bits (113), Expect = 2.943e-6
Identity = 53/177 (29.94%), Postives = 80/177 (45.20%), Query Frame = 3 
Query:  480 VTIKTQDGRTFPVNLIEYDTSTGLCLLKILYQSPLFLSALNLSDVKDVYCRTGDFVVSLGASSNSNFSQFSL------GILQTNYAGD---SFSNNYILSEITNQTCLL--PGGPVINLHGKVVGINASNSDLEKSCQVIPVELGRLLLERNKTEINDAVSRVFSCEEKSSSFGCDG 977
            V +K  +G T+   + + D +  +  +KI  ++PL    L L    DV  R G+FVV++G       S FSL      GI+ +   G      SN+ +    T+ T      GGP+INL G+V+GIN        S   IP +  RL L+R             S ++++S FG  G
Sbjct:   13 VRVKLTNGETYNATVQDVDQAADIATIKINVKNPL--PTLRLGKSSDV--RQGEFVVAMG-------SPFSLKNTITSGIVSSAQRGSKELGLSNSNMDYIQTDATIDFGNSGGPLINLDGEVIGINTMKVTAGISF-AIPSDRVRLFLDR-------------SADKQNSWFGESG 164
[Close]
BLAST of Periplasmic serine endoprotease DegP vs. Ensembl Xenopus
Match: mettl3 (methyltransferase like 3 [Source:Xenbase;Acc:XB-GENE-922807])

HSP 1 Score: 51.9878 bits (123), Expect = 8.826e-7
Identity = 48/146 (32.88%), Postives = 69/146 (47.26%), Query Frame = 3 
Query:  411 SGFIVDHTGLILTVGIDLEKCDSVTIKTQDGRTFPVNLIEYDTSTGLCLLKILYQSPLFLSALNLSDVKDVYCRTGDFVVSLGASSNSNFSQFSLGILQTNYAG-------DSFSNNYILSEITNQTCLLPGGPVINLHGKVVGIN 827
            SGFIV   GLI+T    L     + ++ +DG  +   + + D    + L+KI   +P  L  L L    D+  R G+FVV+LG S  S  +  + GI+ T   G       DS         I N      GGP++NL G+V+GIN
Sbjct:  195 SGFIVSDDGLIVTNAHVLTNKQRIKVEVKDGAHYDAKIKDIDQKLDIALIKIDPDAP--LPVLMLGRSADL--RPGEFVVALG-SPFSLQNTVTTGIISTTQRGGKELGLKDSDMEYIQTDAIINYG--NSGGPLVNLDGEVIGIN 333
[Close]
BLAST of Periplasmic serine endoprotease DegP vs. Ensembl Mouse
Match: Htra1 (HtrA serine peptidase 1 [Source:MGI Symbol;Acc:MGI:1929076])

HSP 1 Score: 51.9878 bits (123), Expect = 7.278e-7
Identity = 46/146 (31.51%), Postives = 74/146 (50.68%), Query Frame = 3 
Query:  411 SGFIVDHTGLILTVGIDLEKCDSVTIKTQDGRTFPVNLIEYDTSTGLCLLKILYQSPLFLSALNLSDVKDVYCRTGDFVVSLGASSNSNFSQFSLGILQTNYAGD------SFSNNYILSE-ITNQTCLLPGGPVINLHGKVVGIN 827
            SGFIV   GLI+T    +   + V ++ ++G T+   + + D    + L+KI +Q  L +  L  S       R G+FVV++G S  S  +  + GI+ T   G       +   +YI ++ I N      GGP++NL G+V+GIN
Sbjct:  205 SGFIVSEDGLIVTNAHVVTNKNRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSS----ELRPGEFVVAIG-SPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYG--NSGGPLVNLDGEVIGIN 343
[Close]
BLAST of Periplasmic serine endoprotease DegP vs. Ensembl Mouse
Match: Htra4 (HtrA serine peptidase 4 [Source:MGI Symbol;Acc:MGI:3036260])

HSP 1 Score: 50.0618 bits (118), Expect = 3.187e-6
Identity = 47/161 (29.19%), Postives = 72/161 (44.72%), Query Frame = 3 
Query:  378 LIKNNVINNEQSGFIVDHTGLILTVGIDLEKCDSVTIKTQDGRTFPVNLIEYDTSTGLCLLKILYQSPLFLSALNLSDVKDVYCRTGDFVVSLGASSNSNFSQFSLGILQTNYAG-----------DSFSNNYILSEITNQTCLLPGGPVINLHGKVVGIN 827
            L    + ++  SGFIV   GLI+T    L     + ++ Q G  +   + + D    L L+KI  +    L  L L    D+  R G+FVV+LG S  S  +  + GI+ T   G           D    + I++   +      GGP++NL G V+GIN
Sbjct:  198 LTNQEIPSSSGSGFIVSEDGLIVTNAHVLTNQQKIQVELQSGARYEATVKDIDHKLDLALIKI--EPDTELPVLLLGRSSDL--RAGEFVVALG-SPFSLQNTVTAGIVSTTQRGGRELGLKNSDIDYIQTDAIINHGNS------GGPLVNLDGDVIGIN 347
[Close]
BLAST of Periplasmic serine endoprotease DegP vs. UniProt/SwissProt
Match: sp|Q92JA1|DEGPL_RICCN (Probable periplasmic serine endoprotease DegP-like OS=Rickettsia conorii (strain ATCC VR-613 / Malish 7) OX=272944 GN=htrA PE=3 SV=2)

HSP 1 Score: 60.8474 bits (146), Expect = 7.632e-9
Identity = 47/148 (31.76%), Postives = 72/148 (48.65%), Query Frame = 3 
Query:  411 SGFIVDHTGLILTVGIDLEKCDSVTIKTQDGRTFPVNLIEYDTSTGLCLLKILYQSPLFLSALNLSDVKDVYCRTGDFVVSLGASSNSNFSQFSLGILQT-----NYAGDSFSNNYILSE--ITNQTCLLPGGPVINLHGKVVGINAS 833
            SGFI++  GLI+T    +   D + IK  D       LI  DT T L LLKI  + PL    +   D  D   R GD+V+++G    +     + GI+ +     +   D+  +N+I ++  I N      GGP+ NL  KV+G+N +
Sbjct:  119 SGFIIEPNGLIVTNYHVIANVDKINIKLADNTELSAKLIGNDTKTDLALLKIDSEEPLPF--VEFGDSND--ARVGDWVIAIGNPFGNLGGTVTSGIISSKGRDIDIDTDNIVDNFIQTDAAINNGNS---GGPMFNLDQKVIGVNTA 259
[Close]
BLAST of Periplasmic serine endoprotease DegP vs. UniProt/SwissProt
Match: sp|B4JTT7|HTRA2_DROGR (Serine protease HTRA2, mitochondrial OS=Drosophila grimshawi OX=7222 GN=HtrA2 PE=3 SV=1)

HSP 1 Score: 60.8474 bits (146), Expect = 7.735e-9
Identity = 57/185 (30.81%), Postives = 91/185 (49.19%), Query Frame = 3 
Query:  411 SGFIVDHTGLILT-VGIDLEKCDS-VTIKTQDGRTFPVNLIEYDTSTGLCLLKILYQSPLFLSALNLSDVKDVYCRTGDFVVSLGA-------------SSNSNFSQFSLGI-------LQTNYAGDSFSNNYILSEITNQTCLLPGGPVINLHGKVVGINASNSDLEKSCQVIPVELGRLLLER 899
            SGF+++  GLILT   + + K ++ V ++  DGRTFP  + + D ++ L  L+I   +   LS + L   K    R+G++VV+LG+             SS    SQ  LG+       LQT+ A  +F N+              GGP++NL G+ +G+N+       S   IP++  +L LER
Sbjct:  146 SGFVIEQNGLILTNAHVVINKPNTMVQVRLSDGRTFPATIEDVDQTSDLATLRIQVTN---LSVMKLG--KSSTLRSGEWVVALGSPLALSNTVTAGVISSTQRASQ-ELGLRNRDINYLQTD-AAITFGNS--------------GGPLVNLDGEAIGVNSMKVTAGISF-AIPIDYVKLFLER 308
[Close]
BLAST of Periplasmic serine endoprotease DegP vs. UniProt/SwissProt
Match: sp|B4K835|HTRA2_DROMO (Serine protease HTRA2, mitochondrial OS=Drosophila mojavensis OX=7230 GN=HtrA2 PE=3 SV=1)

HSP 1 Score: 60.077 bits (144), Expect = 1.459e-8
Identity = 56/185 (30.27%), Postives = 91/185 (49.19%), Query Frame = 3 
Query:  411 SGFIVDHTGLILT-VGIDLEKCDS-VTIKTQDGRTFPVNLIEYDTSTGLCLLKILYQSPLFLSALNLSDVKDVYCRTGDFVVSLGA-------------SSNSNFSQFSLGI-------LQTNYAGDSFSNNYILSEITNQTCLLPGGPVINLHGKVVGINASNSDLEKSCQVIPVELGRLLLER 899
            SGF+++  GLILT   + + K ++ V ++  DGRTFP  + + D ++ L  L+I   +   LS + L   K    R+G++VV+LG+             SS    SQ  LG+       LQT+ A  +F N+              GGP++NL G+ +G+N+       S   IP++  ++ LER
Sbjct:  150 SGFVIEQNGLILTNAHVVINKPNTMVQVRLSDGRTFPATIEDVDQTSDLATLRIQVNN---LSVMKLG--KSSTLRSGEWVVALGSPLALSNTVTAGVISSTQRASQ-ELGLRNRDINYLQTD-AAITFGNS--------------GGPLVNLDGEAIGVNSMKVTAGISF-AIPIDYVKVFLER 312
[Close]
BLAST of Periplasmic serine endoprotease DegP vs. UniProt/SwissProt
Match: sp|Q9VFJ3|HTRA2_DROME (Serine protease HTRA2, mitochondrial OS=Drosophila melanogaster OX=7227 GN=HtrA2 PE=1 SV=1)

HSP 1 Score: 59.6918 bits (143), Expect = 1.698e-8
Identity = 57/185 (30.81%), Postives = 90/185 (48.65%), Query Frame = 3 
Query:  411 SGFIVDHTGLILT-VGIDLEKCDS-VTIKTQDGRTFPVNLIEYDTSTGLCLLKILYQSPLFLSALNLSDVKDVYCRTGDFVVSLGA-------------SSNSNFSQFSLGI-------LQTNYAGDSFSNNYILSEITNQTCLLPGGPVINLHGKVVGINASNSDLEKSCQVIPVELGRLLLER 899
            SGFI++  GLILT   + + K  + V ++  DGRTFP  + + D ++ L  L+I   +   LS + L   K    R+G++VV+LG+             SS    SQ  LG+       LQT+ A  +F N+              GGP++NL G+ +G+N+       S   IP++  ++ LER
Sbjct:  142 SGFIIEQNGLILTNAHVVINKPHTMVQVRLSDGRTFPATIEDVDQTSDLATLRIQVNN---LSVMRLG--KSSTLRSGEWVVALGSPLALSNTVTAGVISSTQRASQ-ELGLRNRDINYLQTD-AAITFGNS--------------GGPLVNLDGEAIGVNSMKVTAGISF-AIPIDYVKVFLER 304
[Close]
BLAST of Periplasmic serine endoprotease DegP vs. UniProt/SwissProt
Match: sp|B4LY58|HTRA2_DROVI (Serine protease HTRA2, mitochondrial OS=Drosophila virilis OX=7244 GN=HtrA2 PE=3 SV=1)

HSP 1 Score: 59.6918 bits (143), Expect = 1.756e-8
Identity = 56/185 (30.27%), Postives = 91/185 (49.19%), Query Frame = 3 
Query:  411 SGFIVDHTGLILT-VGIDLEKCDS-VTIKTQDGRTFPVNLIEYDTSTGLCLLKILYQSPLFLSALNLSDVKDVYCRTGDFVVSLGA-------------SSNSNFSQFSLGI-------LQTNYAGDSFSNNYILSEITNQTCLLPGGPVINLHGKVVGINASNSDLEKSCQVIPVELGRLLLER 899
            SGF+++  GLILT   + + K ++ V ++  DGRTFP  + + D ++ L  L+I   +   LS + L   K    R+G++VV+LG+             SS    SQ  LG+       LQT+ A  +F N+              GGP++NL G+ +G+N+       S   IP++  ++ LER
Sbjct:  141 SGFVIEQNGLILTNAHVVINKPNTMVQVRLSDGRTFPATIEDVDQTSDLATLRIQVNN---LSVMKLG--KSSTLRSGEWVVALGSPLALSNTVTAGVISSTQRASQ-ELGLRNRDINYLQTD-AAITFGNS--------------GGPLVNLDGEAIGVNSMKVTAGISF-AIPIDYVKVFLER 303
[Close]
BLAST of Periplasmic serine endoprotease DegP vs. TrEMBL
Match: A0A517ZVP1 (Putative periplasmic serine endoprotease DegP-like OS=Planctomycetes bacterium Mal52 OX=2527995 GN=mucD_2 PE=4 SV=1)

HSP 1 Score: 77.0258 bits (188), Expect = 1.532e-11
Identity = 47/142 (33.10%), Postives = 80/142 (56.34%), Query Frame = 3 
Query:  411 SGFIVDHTGLILTVGIDLEKCDSVTIKTQDGRTFPVNLIEYDTSTGLCLLKILYQSPLFLSALNLSDVKDVYCRTGDFVVSLGASSNSNFSQFSLGILQTNYAGDSFSN-NYILSEITNQTCLLPGGPVINLHGKVVGINAS 833
            SGF++D +G+I+T    ++  D V ++ QDGR +  + I+ D S+ + +LK+    P  L AL L D +D+  + GD+V+++G+    + S  + GI+     G   +   Y L           GGP+INL+G+VVG+NA+
Sbjct:  115 SGFVIDPSGIIMTNNHVVQDADKVVVRFQDGREYVAHDIKRDPSSDIAILKVDADHP--LPALPLGDSEDI--QVGDWVLAIGSPFGLDMS-VTAGIISAKGRGQQIAEREYFLQTDAAVNPGNSGGPLINLNGEVVGVNAA 251
[Close]
BLAST of Periplasmic serine endoprotease DegP vs. TrEMBL
Match: A0A5C6BPM6 (Putative periplasmic serine endoprotease DegP-like OS=Planctomycetes bacterium CA54 OX=2527985 GN=mucD_2 PE=4 SV=1)

HSP 1 Score: 76.2554 bits (186), Expect = 2.762e-11
Identity = 47/142 (33.10%), Postives = 79/142 (55.63%), Query Frame = 3 
Query:  411 SGFIVDHTGLILTVGIDLEKCDSVTIKTQDGRTFPVNLIEYDTSTGLCLLKILYQSPLFLSALNLSDVKDVYCRTGDFVVSLGASSNSNFSQFSLGILQTNYAGDSFSN-NYILSEITNQTCLLPGGPVINLHGKVVGINAS 833
            SGF++D +G+I+T    ++  D V ++ QDGR +    I+ D S+ + +LKI    P  L AL + D +D+  + GD+V+++G+    + S  + GI+     G   +   Y L           GGP+INL+G+VVG+NA+
Sbjct:  115 SGFVIDPSGIIMTNNHVVQDADKVVVRFQDGREYVARDIKRDPSSDIAILKIDADHP--LPALPMGDSEDI--QVGDWVLAIGSPFGLDMS-VTAGIISAKGRGQQIAEREYFLQTDAAVNPGNSGGPLINLNGEVVGVNAA 251
[Close]
BLAST of Periplasmic serine endoprotease DegP vs. TrEMBL
Match: A0A2G6NDZ6 (Periplasmic serine endoprotease DegP-like OS=Deltaproteobacteria bacterium OX=2026735 GN=CSA22_07530 PE=3 SV=1)

HSP 1 Score: 73.1738 bits (178), Expect = 2.114e-10
Identity = 59/183 (32.24%), Postives = 93/183 (50.82%), Query Frame = 3 
Query:  411 SGFIVDHTGLILTVGIDLEKCDSVTIKTQDGRTFPVNLIEYDTSTGLCLLKILYQSPLFLSALNLSDVKDVYCRTGDFVVSLGASSNSNFSQFSLGILQTNYAGDSFSNNYILSE------ITNQTCLLP---GGPVINLHGKVVGINASNSDLEKSCQ----VIPVELGRLLLE--RNKTEI 914
            SGFI+D  G I+T    +E  D++ +K  D R F   +I  D +T L L+K+  +SPL + +L  S   DV    G++VV++G+           G+ QT  AG   +   ++        I     + P   GGP++NL G+VVGIN +   +  S Q     IPV+L R +++  +NK E+
Sbjct:   95 SGFIIDPEGYIVTNNHVIEGADTIKVKLNDEREFDAEIIGRDENTDLALIKVASESPLPILSLGTSASLDV----GEWVVAIGS---------PFGLEQTVTAGIVSAKGRVIGSGPYDDFIQTDASINPGNSGGPLLNLSGEVVGINTA---IIASGQGIGFAIPVDLARGIVDQLKNKGEV 261
[Close]
BLAST of Periplasmic serine endoprotease DegP vs. TrEMBL
Match: A0A2D7Y6J5 (Periplasmic serine endoprotease DegP-like OS=Maricaulis sp. OX=1486257 GN=CMF75_10025 PE=3 SV=1)

HSP 1 Score: 71.2478 bits (173), Expect = 8.828e-10
Identity = 47/152 (30.92%), Postives = 76/152 (50.00%), Query Frame = 3 
Query:  393 VINNEQSGFIVDHTGLILTVGIDLEKCDSVTIKTQDGRTFPVNLIEYDTSTGLCLLKILYQSPLFLSALNLSDVKDVYCRTGDFVVSLGASSNSNFSQFSLGILQTNYAGDSFS-------NNYILSEITNQTCLLPGGPVINLHGKVVGIN 827
            + N+  SGFI+D  GL++T    ++  D V +   DGR FP +++  D  T L +L++    PL   +   SD      R GD+V+++G       + F LG   T   G +         ++YI +++   T    GGP+ NL G+VVG+N
Sbjct:   74 IANSLGSGFIIDSAGLVVTNNHVIDGADEVEVSLPDGRVFPADVVGIDPVTDLAVLRMQVSEPLPFVSFGDSDT----ARVGDWVIAIG-------NPFGLGGTLTAGVGSARGREVGGRYDDYIQTDVAINTG-NSGGPLFNLDGEVVGVN 213
[Close]
BLAST of Periplasmic serine endoprotease DegP vs. TrEMBL
Match: A0A550KID6 (Periplasmic serine endoprotease DegP-like OS=Glycocaulis sp. ZYF765 OX=2518983 GN=FKB34_09895 PE=3 SV=1)

HSP 1 Score: 71.2478 bits (173), Expect = 1.120e-9
Identity = 44/151 (29.14%), Postives = 81/151 (53.64%), Query Frame = 3 
Query:  390 NVINNEQSGFIVDHTGLILTVGIDLEKCDSVTIKTQDGRTFPVNLIEYDTSTGLCLLKILYQSPLFLSALNLSDVKDVYCRTGDFVVSLGASSNSNFSQFSLGIL--QTNYAGDSFSNNYILSEIT-NQTCLLPGGPVINLHGKVVGINAS 833
             V N+  SGF++D  GL++T    +++ D V +   DGRT+P  +I  D +T L LL+I  + P   +    SD      R GD+VV++G       S  + G++  +    G  + ++Y+ +++  N+     GGP+ ++ G+V+G+N +
Sbjct:   72 RVANSLGSGFVIDDAGLVVTNNHVIDEADDVEVTFPDGRTYPAEIIGSDAATDLALLRIEAEGPFPAARWGDSDA----ARVGDWVVAIGNPFGLGGS-LTAGVISARGREIGGQY-DDYLQTDVAINRGNS--GGPMFDMDGRVIGVNTA 214
[Close]
BLAST of Periplasmic serine endoprotease DegP vs. Ensembl Cavefish
Match: htra1a (serine protease HTRA1A [Source:NCBI gene;Acc:103042183])

HSP 1 Score: 53.5286 bits (127), Expect = 1.947e-7
Identity = 47/146 (32.19%), Postives = 78/146 (53.42%), Query Frame = 3 
Query:  411 SGFIVDHTGLILTVGIDLEKCDSVTIKTQDGRTFPVNLIEYDTSTGLCLLKILYQSPLFLSALNLSDVKDVYCRTGDFVVSLGASSNSNFSQFSLGILQTNYAGD------SFSNNYILSE-ITNQTCLLPGGPVINLHGKVVGIN 827
            SGF+V   GLI+T    +   + V ++ ++G ++   + + D  + + L+KI   SP  LS L+L    D+  R G+FVV++G S  S  +  + GI+ T   G       +   +YI ++ I N      GGP++NL G+V+GIN
Sbjct:  206 SGFVVSDDGLIVTNAHVVANKNRVKVELKNGASYDAKIKDVDEKSDIALIKI--DSPSKLSVLSLGRSADL--RPGEFVVAIG-SPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYG--NSGGPLVNLDGEVIGIN 344
[Close]
BLAST of Periplasmic serine endoprotease DegP vs. Ensembl Cavefish
Match: htra1b (serine protease HTRA1B-like [Source:NCBI gene;Acc:103041103])

HSP 1 Score: 53.5286 bits (127), Expect = 2.174e-7
Identity = 49/155 (31.61%), Postives = 76/155 (49.03%), Query Frame = 3 
Query:  384 KNNVINNEQSGFIVDHTGLILTVGIDLEKCDSVTIKTQDGRTFPVNLIEYDTSTGLCLLKILYQSPLFLSALNLSDVKDVYCRTGDFVVSLGASSNSNFSQFSLGILQTNYAGD------SFSNNYILSE-ITNQTCLLPGGPVINLHGKVVGIN 827
            K  V     SGFIV   GLI+T    +     V ++ + G T+   + + D    + L+KI   +P+ L  L L    D+  R G+FVV++G S  S  +  + GI+ T   G       +   +YI ++ I N      GGP++NL G+V+GIN
Sbjct:  187 KREVAVASGSGFIVSEDGLIVTNAHVVANKHRVKVELKSGATYDAKIKDVDEKADIALIKI--DAPMKLPVLLLGRSADL--RPGEFVVAIG-SPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYG--NSGGPLVNLDGEVIGIN 334
[Close]
BLAST of Periplasmic serine endoprotease DegP vs. Ensembl Cavefish
Match: si:dkey-33c12.12 (serine protease HTRA2, mitochondrial [Source:NCBI gene;Acc:103043568])

HSP 1 Score: 52.373 bits (124), Expect = 4.936e-7
Identity = 50/155 (32.26%), Postives = 74/155 (47.74%), Query Frame = 3 
Query:  411 SGFIVDHTGLILTVGIDLEKCDSVTIKTQDGRTFPVNLIEYDTSTGLCLLKILYQSPLFLSALNLSDVKDVYCRTGDFVVSLGASSNSNFSQFSL------GILQTNYAGDS---FSN---NYILSEIT----NQTCLLPGGPVINLHGKVVGIN 827
            SGFIV   GLI+T    +     V +K   G T+   + + D +  +  +KI  + P  L  L L+   +V  R G+FVV++G       S F+L      GI+ +   G      SN   +YI ++ T    N      GGP+INL G+V+GIN
Sbjct:  169 SGFIVSSDGLIVTNAHVVANKRDVRVKLTSGETYNAVVQDVDQAADIATIKIQPKHP--LPTLRLAQSSEV--RQGEFVVAMG-------SPFALRNTITSGIVSSTQRGSKELGLSNPNMDYIQTDATIDFGNS-----GGPLINLDGEVIGIN 307
[Close]
BLAST of Periplasmic serine endoprotease DegP vs. Ensembl Sea Lamprey
Match: HTRA1 (HtrA serine peptidase 1 [Source:HGNC Symbol;Acc:HGNC:9476])

HSP 1 Score: 52.7582 bits (125), Expect = 4.427e-8
Identity = 54/184 (29.35%), Postives = 85/184 (46.20%), Query Frame = 3 
Query:  378 LIKNNVINNEQSGFIVDHTGLILT-VGIDLEKCDSVTIKTQ--DGRTFPVNLIEYDTSTGLCLLKILYQSPLFLSALNLSDVKDVYCRTGDFVVSLGASSNSNFSQFSLGILQTNYAG------DSFSNNYILSE-ITNQTCLLPGGPVINLHGKVVGINASNSDLEKSCQVIPVELGRLLLER 899
            L   NV  +  SGF+V   GLILT   +   K D V +K Q  +G T+    +  D    + ++KI  +  L +  L     +    R G+FVV++G+      +  + GI+ T   G      D   ++YI ++ + N      GGP++NL G+VVGIN        S  +    +  LLL+R
Sbjct:  125 LFDRNVSVSSGSGFLVSEDGLILTNAHVVTHKRDLVAVKVQLTNGDTYEAWPLHVDMHANIAVIKINAKQKLPVLRL----ARSAELRPGEFVVAIGSPFKLQ-NTVTTGIVSTAQRGGQELGLDDSDHDYIQTDAMVNYGSA--GGPLVNLDGEVVGINTLKVTAGISFAIPSDRIRELLLQR 301
[Close]
BLAST of Periplasmic serine endoprotease DegP vs. Ensembl Medaka
Match: htra1b (HtrA serine peptidase 1 [Source:NCBI gene;Acc:101160199])

HSP 1 Score: 49.2914 bits (116), Expect = 3.946e-6
Identity = 46/146 (31.51%), Postives = 73/146 (50.00%), Query Frame = 3 
Query:  411 SGFIVDHTGLILTVGIDLEKCDSVTIKTQDGRTFPVNLIEYDTSTGLCLLKILYQSPLFLSALNLSDVKDVYCRTGDFVVSLGASSNSNFSQFSLGILQTNYAGD------SFSNNYILSE-ITNQTCLLPGGPVINLHGKVVGIN 827
            SGF+V   GLI+T    +     V ++ + G T+   + + D    + L+KI   +P  L  L L    D+  R G+FVV++G S  S  +  + GI+ T   G       +   +YI ++ I N      GGP++NL G+V+GIN
Sbjct:  201 SGFVVSEDGLIVTNAHVVANKHRVKVELKSGATYDAKIKDIDEKADIALIKI--DTPNKLPVLLLGRSADL--RPGEFVVAIG-SPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYG--NSGGPLVNLDGEVIGIN 339
[Close]
BLAST of Periplasmic serine endoprotease DegP vs. Ensembl Medaka
Match: htra1a (serine protease HTRA1A [Source:NCBI gene;Acc:105355810])

HSP 1 Score: 48.521 bits (114), Expect = 8.031e-6
Identity = 46/155 (29.68%), Postives = 75/155 (48.39%), Query Frame = 3 
Query:  384 KNNVINNEQSGFIVDHTGLILTVGIDLEKCDSVTIKTQDGRTFPVNLIEYDTSTGLCLLKILYQSPLFLSALNLSDVKDVYCRTGDFVVSLGASSNSNFSQFSLGILQTNYAGD------SFSNNYILSE-ITNQTCLLPGGPVINLHGKVVGIN 827
            K  V     SGF+V   G I+T    +     V ++ ++G ++   + + D    + L+KI   +P  L  L L    D+  R G+FVV++G S  S  +  + GI+ T   G       +   +YI ++ I N      GGP++NL G+V+GIN
Sbjct:  192 KREVAVASGSGFVVSEDGQIVTNAHVVANKHRVKVELKNGASYDAKIKDVDEKADIALIKI--DAPTKLPVLLLGHSSDL--RPGEFVVAIG-SPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYG--NSGGPLVNLDGEVIGIN 339
[Close]
BLAST of Periplasmic serine endoprotease DegP vs. Planmine SMEST
Match: SMESG000038157.1 (SMESG000038157.1)

HSP 1 Score: 375.941 bits (964), Expect = 2.169e-131
Identity = 211/212 (99.53%), Postives = 212/212 (100.00%), Query Frame = 3 
Query:   33 MKALTIRRNVLIFNKKFYQTSTRLFHNLIXXXXXXXXXXXXFRNVEDNFMQLINFLAGCGMGLMIGLVLRKRVSKPIVKDEIIPFADSIPKCPMKSRVTLAPLLXXXXXXXXXXRLIKNNVINNEQSGFIVDHTGLILTVGIDLEKCDSVTIKTQDGRTFPVNLIEYDTSTGLCLLKILYQSPLFLSALNLSDVKDVYCRTGDFVVSLGASS 668
            MKALTIRRNVLIFNKKFYQTSTRLFHNLISNNGSSKKNESNFRNVEDNFMQLINFLAGCGMGLMIGLVLRKRVSKPIVKDEIIPFADSIPKCPMKSRVTLAPLLSNSSASVVSVRLIKNNVINNEQSGFIVDHTGLILTVGIDLEKCDSVTIKTQDGRTFPVNLIEYDTSTGLCLLKILYQSPLFLSALNLSDVKDVYCRTGDFVVSLGAS+
Sbjct:    1 MKALTIRRNVLIFNKKFYQTSTRLFHNLISNNGSSKKNESNFRNVEDNFMQLINFLAGCGMGLMIGLVLRKRVSKPIVKDEIIPFADSIPKCPMKSRVTLAPLLSNSSASVVSVRLIKNNVINNEQSGFIVDHTGLILTVGIDLEKCDSVTIKTQDGRTFPVNLIEYDTSTGLCLLKILYQSPLFLSALNLSDVKDVYCRTGDFVVSLGASN 212
[Close]
BLAST of Periplasmic serine endoprotease DegP vs. Planmine SMEST
Match: SMESG000006679.1 (SMESG000006679.1)

HSP 1 Score: 54.299 bits (129), Expect = 6.530e-8
Identity = 44/144 (30.56%), Postives = 78/144 (54.17%), Query Frame = 3 
Query:  411 SGFIVDHTGLILTVGIDLEKCDSVTIKTQDGRTFPVNLIEYDTSTGLCLLKILYQSPLFLSALNLSDVKDVYCRTGDFVVSLGAS---SNSNFSQFSLGILQT--NYAGDSFSNNYILSEITNQTCLLPGGPVINLHGKVVGIN 827
            SGFIV+ +G ILT    + +   V++   DG+ F   +I  D S+ L L+K+     + L +L  +++  +  R G+FV++LG+    SNS     ++G++       G S    Y+ ++    T    GGP++NL+G+V+G+N
Sbjct:   73 SGFIVEDSGYILTNAHVVARNPYVSVTLSDGQKFQGEVIAMDRSSDLALVKV-NPGKIKLQSLRFAEISKL--RAGEFVIALGSPMTLSNS----VTVGVVSAVQRDLGHSKGLRYVQTDAI-ITVGNSGGPLVNLYGEVIGVN 208
[Close]
BLAST of Periplasmic serine endoprotease DegP vs. Planmine SMEST
Match: SMESG000006679.1 (SMESG000006679.1)

HSP 1 Score: 54.299 bits (129), Expect = 6.568e-8
Identity = 44/144 (30.56%), Postives = 78/144 (54.17%), Query Frame = 3 
Query:  411 SGFIVDHTGLILTVGIDLEKCDSVTIKTQDGRTFPVNLIEYDTSTGLCLLKILYQSPLFLSALNLSDVKDVYCRTGDFVVSLGAS---SNSNFSQFSLGILQT--NYAGDSFSNNYILSEITNQTCLLPGGPVINLHGKVVGIN 827
            SGFIV+ +G ILT    + +   V++   DG+ F   +I  D S+ L L+K+     + L +L  +++  +  R G+FV++LG+    SNS     ++G++       G S    Y+ ++    T    GGP++NL+G+V+G+N
Sbjct:   72 SGFIVEDSGYILTNAHVVARNPYVSVTLSDGQKFQGEVIAMDRSSDLALVKV-NPGKIKLQSLRFAEISKL--RAGEFVIALGSPMTLSNS----VTVGVVSAVQRDLGHSKGLRYVQTDAI-ITVGNSGGPLVNLYGEVIGVN 207
[Close]
BLAST of Periplasmic serine endoprotease DegP vs. Planmine SMEST
Match: SMESG000006682.1 (SMESG000006682.1)

HSP 1 Score: 53.1434 bits (126), Expect = 9.001e-8
Identity = 42/140 (30.00%), Postives = 73/140 (52.14%), Query Frame = 3 
Query:  408 QSGFIVDHTGLILTVGIDLEKCDSVTIKTQDGRTFPVNLIEYDTSTGLCLLKILYQSPLFLSALNLSDVKDVYCRTGDFVVSLGASSNSNFSQFSLGILQTNYAGDSFSN-NYILSEITNQTCLLPGGPVINLHGKVVGI 824
            ++G I+  +GLILT     +      I   DG  +   +I  +    L LLKI  ++ L L +L+ ++   V  + G+F++++G  SN    + +LG++        + N N IL+++      L GGP+INL G+V+GI
Sbjct:   65 ETGIIIHKSGLILTTAEMTKYRSKFDITLHDGTKYEAEIITANEKNNLALLKINLEN-LQLKSLHFNEKSKV--KIGEFILTVGNISNVK-CKVALGVVSGFVKSKEYENVNVILTDVEMTDSNL-GGPLINLKGEVIGI 199
[Close]
BLAST of Periplasmic serine endoprotease DegP vs. Planmine SMEST
Match: SMESG000006683.1 (SMESG000006683.1)

HSP 1 Score: 50.0618 bits (118), Expect = 9.123e-7
Identity = 40/143 (27.97%), Postives = 70/143 (48.95%), Query Frame = 3 
Query:  411 SGFIVDHTGLILTVGIDLEKCDSVTIKTQDGRTFPVNLIEYDTSTGLCLLKILYQSPLFLSALNLSDVKDVYCRTGDFVVSLGASSNSNFSQFSLGILQ-TNYAGDSFSN---NYILSEITNQTCLLPGGPVINLHGKVVGIN 827
            SGF+ D +G ILT    ++      ++   G TF  ++I  D    L L+KI     L L +L       +  + G+  ++LG   ++  +  ++G++  T   G  F+     YI ++   Q     GGP++NLHGKV+G++
Sbjct:   83 SGFVFDESGYILTCAHVIQDEHDTLVRVHSGETFKAHVIMKDDPMDLALIKI-NSGKLKLKSLKFESHTSI--KVGELALALGNYLST--TSATMGVVSGTERYGSLFAYKNVKYIQTDALIQPG-FSGGPLVNLHGKVIGMS 219
The following BLAST results are available for this feature:
BLAST of Periplasmic serine endoprotease DegP vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 2
Match NameE-valueIdentityDescription
HTRA15.369e-731.51HtrA serine peptidase 1 [Source:HGNC Symbol;Acc:HG... [more]
HTRA11.345e-631.51HtrA serine peptidase 1 [Source:HGNC Symbol;Acc:HG... [more]
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BLAST of Periplasmic serine endoprotease DegP vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Periplasmic serine endoprotease DegP vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2
Match NameE-valueIdentityDescription
HtrA21.694e-930.81gene:FBgn0038233 transcript:FBtr0082987[more]
HtrA21.694e-930.81gene:FBgn0038233 transcript:FBtr0330045[more]
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BLAST of Periplasmic serine endoprotease DegP vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
si:dkey-33c12.125.130e-931.00si:dkey-33c12.12 [Source:ZFIN;Acc:ZDB-GENE-081028-... [more]
si:dkey-33c12.125.130e-931.00si:dkey-33c12.12 [Source:ZFIN;Acc:ZDB-GENE-081028-... [more]
zgc:1741936.087e-829.50zgc:174193 [Source:ZFIN;Acc:ZDB-GENE-080215-8][more]
htra1b1.057e-731.48HtrA serine peptidase 1b [Source:NCBI gene;Acc:565... [more]
si:dkey-33c12.122.943e-629.94si:dkey-33c12.12 [Source:ZFIN;Acc:ZDB-GENE-081028-... [more]
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BLAST of Periplasmic serine endoprotease DegP vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1
Match NameE-valueIdentityDescription
mettl38.826e-732.88methyltransferase like 3 [Source:Xenbase;Acc:XB-GE... [more]
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BLAST of Periplasmic serine endoprotease DegP vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Htra17.278e-731.51HtrA serine peptidase 1 [Source:MGI Symbol;Acc:MGI... [more]
Htra43.187e-629.19HtrA serine peptidase 4 [Source:MGI Symbol;Acc:MGI... [more]
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BLAST of Periplasmic serine endoprotease DegP vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q92JA1|DEGPL_RICCN7.632e-931.76Probable periplasmic serine endoprotease DegP-like... [more]
sp|B4JTT7|HTRA2_DROGR7.735e-930.81Serine protease HTRA2, mitochondrial OS=Drosophila... [more]
sp|B4K835|HTRA2_DROMO1.459e-830.27Serine protease HTRA2, mitochondrial OS=Drosophila... [more]
sp|Q9VFJ3|HTRA2_DROME1.698e-830.81Serine protease HTRA2, mitochondrial OS=Drosophila... [more]
sp|B4LY58|HTRA2_DROVI1.756e-830.27Serine protease HTRA2, mitochondrial OS=Drosophila... [more]
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BLAST of Periplasmic serine endoprotease DegP vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A517ZVP11.532e-1133.10Putative periplasmic serine endoprotease DegP-like... [more]
A0A5C6BPM62.762e-1133.10Putative periplasmic serine endoprotease DegP-like... [more]
A0A2G6NDZ62.114e-1032.24Periplasmic serine endoprotease DegP-like OS=Delta... [more]
A0A2D7Y6J58.828e-1030.92Periplasmic serine endoprotease DegP-like OS=Maric... [more]
A0A550KID61.120e-929.14Periplasmic serine endoprotease DegP-like OS=Glyco... [more]
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BLAST of Periplasmic serine endoprotease DegP vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 3
Match NameE-valueIdentityDescription
htra1a1.947e-732.19serine protease HTRA1A [Source:NCBI gene;Acc:10304... [more]
htra1b2.174e-731.61serine protease HTRA1B-like [Source:NCBI gene;Acc:... [more]
si:dkey-33c12.124.936e-732.26serine protease HTRA2, mitochondrial [Source:NCBI ... [more]
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BLAST of Periplasmic serine endoprotease DegP vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
HTRA14.427e-829.35HtrA serine peptidase 1 [Source:HGNC Symbol;Acc:HG... [more]
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BLAST of Periplasmic serine endoprotease DegP vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Periplasmic serine endoprotease DegP vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Periplasmic serine endoprotease DegP vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2
Match NameE-valueIdentityDescription
htra1b3.946e-631.51HtrA serine peptidase 1 [Source:NCBI gene;Acc:1011... [more]
htra1a8.031e-629.68serine protease HTRA1A [Source:NCBI gene;Acc:10535... [more]
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BLAST of Periplasmic serine endoprotease DegP vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000038157.12.169e-13199.53SMESG000038157.1[more]
SMESG000006679.16.530e-830.56SMESG000006679.1[more]
SMESG000006679.16.568e-830.56SMESG000006679.1[more]
SMESG000006682.19.001e-830.00SMESG000006682.1[more]
SMESG000006683.19.123e-727.97SMESG000006683.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30031874 ID=SMED30031874|Name=Periplasmic serine endoprotease DegP|organism=Schmidtea mediterranea sexual|type=transcript|length=1143bp
TTTTTAAATAAATCGTTCAATATTAATAAAATATGAAGGCTTTGACCATT
CGAAGAAATGTTTTAATTTTCAACAAAAAATTCTATCAAACTTCAACACG
ATTATTCCACAACCTTATCAGTAATAATGGTAGTTCCAAAAAAAATGAAT
CGAATTTCAGAAACGTTGAAGATAATTTTATGCAACTGATAAATTTTCTT
GCTGGCTGCGGAATGGGGCTTATGATTGGTTTGGTTTTGAGAAAGCGAGT
GAGCAAACCAATCGTAAAAGACGAAATCATTCCTTTTGCGGATAGCATTC
CAAAGTGTCCAATGAAATCAAGAGTAACATTAGCGCCTTTACTTTCAAAT
TCTAGTGCATCTGTTGTTAGTGTTAGACTAATTAAAAATAATGTCATAAA
TAATGAACAATCCGGTTTTATTGTTGACCATACCGGCTTAATTTTGACTG
TTGGTATTGATTTAGAGAAGTGTGACTCTGTCACGATTAAGACCCAAGAT
GGTCGAACGTTTCCAGTTAATCTAATTGAGTATGACACCTCAACAGGATT
ATGTTTATTAAAAATATTGTACCAATCACCTTTATTCTTGTCCGCGCTGA
ATTTATCAGATGTCAAAGATGTTTATTGTAGAACGGGAGATTTTGTTGTT
TCGCTTGGAGCGTCTAGTAACAGTAATTTCAGTCAGTTTTCATTAGGTAT
TTTACAGACGAATTATGCCGGAGACTCGTTTTCCAATAATTACATTTTAT
CAGAAATAACTAACCAGACATGTCTATTGCCTGGTGGGCCTGTGATAAAT
TTACATGGGAAAGTAGTTGGAATTAATGCATCTAATTCAGATCTGGAAAA
ATCATGTCAAGTTATTCCTGTTGAGTTAGGCAGATTGTTGTTGGAAAGAA
ACAAAACAGAGATTAATGATGCCGTTAGTAGAGTTTTTTCATGTGAAGAA
AAGTCATCCAGTTTCGGATGTGATGGTAAATTAACATCACTTCAAAAAGA
AAGCTATTTTAAATGAAAATTATTCAAATTAAATTATTTTTTCAAAGAAT
TATTGATAAATTTAGTTTTCTTATTTTACATTTTAAAGACATTATTTGAT
GACCCTAATGTAGCTTGAAATGAAAATTTTGTAATCAAATAAG
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protein sequence of SMED30031874-orf-1

>SMED30031874-orf-1 ID=SMED30031874-orf-1|Name=SMED30031874-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=328bp
MKALTIRRNVLIFNKKFYQTSTRLFHNLISNNGSSKKNESNFRNVEDNFM
QLINFLAGCGMGLMIGLVLRKRVSKPIVKDEIIPFADSIPKCPMKSRVTL
APLLSNSSASVVSVRLIKNNVINNEQSGFIVDHTGLILTVGIDLEKCDSV
TIKTQDGRTFPVNLIEYDTSTGLCLLKILYQSPLFLSALNLSDVKDVYCR
TGDFVVSLGASSNSNFSQFSLGILQTNYAGDSFSNNYILSEITNQTCLLP
GGPVINLHGKVVGINASNSDLEKSCQVIPVELGRLLLERNKTEINDAVSR
VFSCEEKSSSFGCDGKLTSLQKESYFK*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0016787hydrolase activity
GO:0004252serine-type endopeptidase activity
GO:0008233peptidase activity
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002111X2 cell
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR009003Peptidase_S1_PA
Vocabulary: biological process
TermDefinition
GO:0006508proteolysis