Msh2
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30031773 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 39Note: Hover over icons to view figure legend
Homology
BLAST of Msh2 vs. Ensembl Human
Match: MSH2 (mutS homolog 2 [Source:HGNC Symbol;Acc:HGNC:7325]) HSP 1 Score: 624.394 bits (1609), Expect = 0.000e+0 Identity = 342/841 (40.67%), Postives = 526/841 (62.54%), Query Frame = 1
Query: 28 SFSLFWNSLGDKPNSTIRFFDRQDYYTVHFEDAEMLARSYYKSMEILKYFRRDSVSS-PYINISKSNSDGVFKYLLIANQYKVEVYSN---NKS--HDSWNLDFVATPGNLEKYQDILFKDVELVSSNSLLGLNIKRINDDYRIFLGFCDLDNGIFMIGGFEESFTGYEQLANLSSALFQLNCRECLIPN-DTRPELLAVKNAVQSAGLLVTEVKKSFFSSENVMNSILKLICKTKLNNENTVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNILP-SPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFDESRT-FQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYE 2523
F F+ + +KP +T+R FDR D+YT H EDA + AR +K+ ++KY + + +SK N + K LL+ QY+VEVY N NK+ + W L + A+PGNL +++DILF + ++ +S ++G+ + ++ ++ +G+ D I G E F +Q +NL + L Q+ +EC++P +T ++ ++ +Q G+L+TE KK+ FS++++ + +L+ K N+ + L + E + L +VI +L+L +D+S F F++ TF YM++ RALN+ S D SL LLN C+T G+RL+ QWIKQPLMD N I RL++VE+ + D +LR L E+ LRR PDL R+ ++ QR NLQD Y+LY + Q +++ L +H G ++ ++ + + + ++ D F +M + D + V+NHEF VK D +L E M L+ +M++ + LG++ KQ+K +SS GYY RV+ K+E VLRN S ++ K+GVKF ++++T +NE Y +++ +YEE + +I++EI+ I++ YV + L+ ++A+LD + S A + GAP Y RP +++ + R+ +K RH VE+Q+ +++I ND+ F++ + F IITGPNMGGKSTYIR G+I +MAQIG FVPC+ AE+SI D I+ R+GAGD QL GVSTFMAEML+ + IL++AT SLIIIDELGRGTST+DGFGLAW+ISE+IAT++ AF FATHFHELT L+ VNNLHVTA T L +Y+V++G +S+GI VA+ + P I+ AK K E E
Sbjct: 18 GFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVD---SIQRKLGLCE-FPDNDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQDLNRLLKGKKGEQMNSAV-LPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELTTFDFSQYMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERLNLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKFQEMIETTLDMDQVENHEFLVKPSFDPNLSELREIMNDLEKKMQSTLISAARDLGLDPGKQIKLDSSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTNSKLTSLNEEYTKNKTEYEEAQDAIVKEIVNISSGYVEPMQTLNDVLAQLDAVVSFAHVSNGAPVPYVRPAILEKGQGRII-LKASRHACVEVQDEIAFIPNDVYFEKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDSQLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAFCMFATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFPKHVIECAKQKALELE 852
BLAST of Msh2 vs. Ensembl Human
Match: MSH2 (mutS homolog 2 [Source:HGNC Symbol;Acc:HGNC:7325]) HSP 1 Score: 624.009 bits (1608), Expect = 0.000e+0 Identity = 342/841 (40.67%), Postives = 526/841 (62.54%), Query Frame = 1
Query: 28 SFSLFWNSLGDKPNSTIRFFDRQDYYTVHFEDAEMLARSYYKSMEILKYFRRDSVSS-PYINISKSNSDGVFKYLLIANQYKVEVYSN---NKS--HDSWNLDFVATPGNLEKYQDILFKDVELVSSNSLLGLNIKRINDDYRIFLGFCDLDNGIFMIGGFEESFTGYEQLANLSSALFQLNCRECLIPN-DTRPELLAVKNAVQSAGLLVTEVKKSFFSSENVMNSILKLICKTKLNNENTVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNILP-SPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFDESRT-FQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYE 2523
F F+ + +KP +T+R FDR D+YT H EDA + AR +K+ ++KY + + +SK N + K LL+ QY+VEVY N NK+ + W L + A+PGNL +++DILF + ++ +S ++G+ + ++ ++ +G+ D I G E F +Q +NL + L Q+ +EC++P +T ++ ++ +Q G+L+TE KK+ FS++++ + +L+ K N+ + L + E + L +VI +L+L +D+S F F++ TF YM++ RALN+ S D SL LLN C+T G+RL+ QWIKQPLMD N I RL++VE+ + D +LR L E+ LRR PDL R+ ++ QR NLQD Y+LY + Q +++ L +H G ++ ++ + + + ++ D F +M + D + V+NHEF VK D +L E M L+ +M++ + LG++ KQ+K +SS GYY RV+ K+E VLRN S ++ K+GVKF ++++T +NE Y +++ +YEE + +I++EI+ I++ YV + L+ ++A+LD + S A + GAP Y RP +++ + R+ +K RH VE+Q+ +++I ND+ F++ + F IITGPNMGGKSTYIR G+I +MAQIG FVPC+ AE+SI D I+ R+GAGD QL GVSTFMAEML+ + IL++AT SLIIIDELGRGTST+DGFGLAW+ISE+IAT++ AF FATHFHELT L+ VNNLHVTA T L +Y+V++G +S+GI VA+ + P I+ AK K E E
Sbjct: 18 GFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVD---SIQRKLGLCE-FPDNDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQDLNRLLKGKKGEQMNSAV-LPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELTTFDFSQYMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERLNLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKFQEMIETTLDMDQVENHEFLVKPSFDPNLSELREIMNDLEKKMQSTLISAARDLGLDPGKQIKLDSSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTNSKLTSLNEEYTKNKTEYEEAQDAIVKEIVNISSGYVEPMQTLNDVLAQLDAVVSFAHVSNGAPVPYVRPAILEKGQGRII-LKASRHACVEVQDEIAFIPNDVYFEKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDSQLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAFCMFATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFPKHVIECAKQKALELE 852
BLAST of Msh2 vs. Ensembl Human
Match: MSH2 (mutS homolog 2 [Source:HGNC Symbol;Acc:HGNC:7325]) HSP 1 Score: 623.624 bits (1607), Expect = 0.000e+0 Identity = 342/841 (40.67%), Postives = 526/841 (62.54%), Query Frame = 1
Query: 28 SFSLFWNSLGDKPNSTIRFFDRQDYYTVHFEDAEMLARSYYKSMEILKYFRRDSVSS-PYINISKSNSDGVFKYLLIANQYKVEVYSN---NKS--HDSWNLDFVATPGNLEKYQDILFKDVELVSSNSLLGLNIKRINDDYRIFLGFCDLDNGIFMIGGFEESFTGYEQLANLSSALFQLNCRECLIPN-DTRPELLAVKNAVQSAGLLVTEVKKSFFSSENVMNSILKLICKTKLNNENTVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNILP-SPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFDESRT-FQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYE 2523
F F+ + +KP +T+R FDR D+YT H EDA + AR +K+ ++KY + + +SK N + K LL+ QY+VEVY N NK+ + W L + A+PGNL +++DILF + ++ +S ++G+ + ++ ++ +G+ D I G E F +Q +NL + L Q+ +EC++P +T ++ ++ +Q G+L+TE KK+ FS++++ + +L+ K N+ + L + E + L +VI +L+L +D+S F F++ TF YM++ RALN+ S D SL LLN C+T G+RL+ QWIKQPLMD N I RL++VE+ + D +LR L E+ LRR PDL R+ ++ QR NLQD Y+LY + Q +++ L +H G ++ ++ + + + ++ D F +M + D + V+NHEF VK D +L E M L+ +M++ + LG++ KQ+K +SS GYY RV+ K+E VLRN S ++ K+GVKF ++++T +NE Y +++ +YEE + +I++EI+ I++ YV + L+ ++A+LD + S A + GAP Y RP +++ + R+ +K RH VE+Q+ +++I ND+ F++ + F IITGPNMGGKSTYIR G+I +MAQIG FVPC+ AE+SI D I+ R+GAGD QL GVSTFMAEML+ + IL++AT SLIIIDELGRGTST+DGFGLAW+ISE+IAT++ AF FATHFHELT L+ VNNLHVTA T L +Y+V++G +S+GI VA+ + P I+ AK K E E
Sbjct: 18 GFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVD---SIQRKLGLCE-FPDNDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQDLNRLLKGKKGEQMNSAV-LPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELTTFDFSQYMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERLNLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKFQEMIETTLDMDQVENHEFLVKPSFDPNLSELREIMNDLEKKMQSTLISAARDLGLDPGKQIKLDSSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTNSKLTSLNEEYTKNKTEYEEAQDAIVKEIVNISSGYVEPMQTLNDVLAQLDAVVSFAHVSNGAPVPYVRPAILEKGQGRII-LKASRHACVEVQDEIAFIPNDVYFEKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDSQLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAFCMFATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFPKHVIECAKQKALELE 852
BLAST of Msh2 vs. Ensembl Human
Match: MSH2 (mutS homolog 2 [Source:HGNC Symbol;Acc:HGNC:7325]) HSP 1 Score: 623.624 bits (1607), Expect = 0.000e+0 Identity = 342/841 (40.67%), Postives = 526/841 (62.54%), Query Frame = 1
Query: 28 SFSLFWNSLGDKPNSTIRFFDRQDYYTVHFEDAEMLARSYYKSMEILKYFRRDSVSS-PYINISKSNSDGVFKYLLIANQYKVEVYSN---NKS--HDSWNLDFVATPGNLEKYQDILFKDVELVSSNSLLGLNIKRINDDYRIFLGFCDLDNGIFMIGGFEESFTGYEQLANLSSALFQLNCRECLIPN-DTRPELLAVKNAVQSAGLLVTEVKKSFFSSENVMNSILKLICKTKLNNENTVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNILP-SPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFDESRT-FQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYE 2523
F F+ + +KP +T+R FDR D+YT H EDA + AR +K+ ++KY + + +SK N + K LL+ QY+VEVY N NK+ + W L + A+PGNL +++DILF + ++ +S ++G+ + ++ ++ +G+ D I G E F +Q +NL + L Q+ +EC++P +T ++ ++ +Q G+L+TE KK+ FS++++ + +L+ K N+ + L + E + L +VI +L+L +D+S F F++ TF YM++ RALN+ S D SL LLN C+T G+RL+ QWIKQPLMD N I RL++VE+ + D +LR L E+ LRR PDL R+ ++ QR NLQD Y+LY + Q +++ L +H G ++ ++ + + + ++ D F +M + D + V+NHEF VK D +L E M L+ +M++ + LG++ KQ+K +SS GYY RV+ K+E VLRN S ++ K+GVKF ++++T +NE Y +++ +YEE + +I++EI+ I++ YV + L+ ++A+LD + S A + GAP Y RP +++ + R+ +K RH VE+Q+ +++I ND+ F++ + F IITGPNMGGKSTYIR G+I +MAQIG FVPC+ AE+SI D I+ R+GAGD QL GVSTFMAEML+ + IL++AT SLIIIDELGRGTST+DGFGLAW+ISE+IAT++ AF FATHFHELT L+ VNNLHVTA T L +Y+V++G +S+GI VA+ + P I+ AK K E E
Sbjct: 18 GFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVD---SIQRKLGLCE-FPDNDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQDLNRLLKGKKGEQMNSAV-LPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELTTFDFSQYMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERLNLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKFQEMIETTLDMDQVENHEFLVKPSFDPNLSELREIMNDLEKKMQSTLISAARDLGLDPGKQIKLDSSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTNSKLTSLNEEYTKNKTEYEEAQDAIVKEIVNISSGYVEPMQTLNDVLAQLDAVVSFAHVSNGAPVPYVRPAILEKGQGRII-LKASRHACVEVQDEIAFIPNDVYFEKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDSQLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAFCMFATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFPKHVIECAKQKALELE 852
BLAST of Msh2 vs. Ensembl Human
Match: MSH2 (mutS homolog 2 [Source:HGNC Symbol;Acc:HGNC:7325]) HSP 1 Score: 623.624 bits (1607), Expect = 0.000e+0 Identity = 342/841 (40.67%), Postives = 526/841 (62.54%), Query Frame = 1
Query: 28 SFSLFWNSLGDKPNSTIRFFDRQDYYTVHFEDAEMLARSYYKSMEILKYFRRDSVSS-PYINISKSNSDGVFKYLLIANQYKVEVYSN---NKS--HDSWNLDFVATPGNLEKYQDILFKDVELVSSNSLLGLNIKRINDDYRIFLGFCDLDNGIFMIGGFEESFTGYEQLANLSSALFQLNCRECLIPN-DTRPELLAVKNAVQSAGLLVTEVKKSFFSSENVMNSILKLICKTKLNNENTVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNILP-SPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFDESRT-FQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYE 2523
F F+ + +KP +T+R FDR D+YT H EDA + AR +K+ ++KY + + +SK N + K LL+ QY+VEVY N NK+ + W L + A+PGNL +++DILF + ++ +S ++G+ + ++ ++ +G+ D I G E F +Q +NL + L Q+ +EC++P +T ++ ++ +Q G+L+TE KK+ FS++++ + +L+ K N+ + L + E + L +VI +L+L +D+S F F++ TF YM++ RALN+ S D SL LLN C+T G+RL+ QWIKQPLMD N I RL++VE+ + D +LR L E+ LRR PDL R+ ++ QR NLQD Y+LY + Q +++ L +H G ++ ++ + + + ++ D F +M + D + V+NHEF VK D +L E M L+ +M++ + LG++ KQ+K +SS GYY RV+ K+E VLRN S ++ K+GVKF ++++T +NE Y +++ +YEE + +I++EI+ I++ YV + L+ ++A+LD + S A + GAP Y RP +++ + R+ +K RH VE+Q+ +++I ND+ F++ + F IITGPNMGGKSTYIR G+I +MAQIG FVPC+ AE+SI D I+ R+GAGD QL GVSTFMAEML+ + IL++AT SLIIIDELGRGTST+DGFGLAW+ISE+IAT++ AF FATHFHELT L+ VNNLHVTA T L +Y+V++G +S+GI VA+ + P I+ AK K E E
Sbjct: 18 GFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVD---SIQRKLGLCE-FPDNDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQDLNRLLKGKKGEQMNSAV-LPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELTTFDFSQYMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERLNLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKFQEMIETTLDMDQVENHEFLVKPSFDPNLSELREIMNDLEKKMQSTLISAARDLGLDPGKQIKLDSSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTNSKLTSLNEEYTKNKTEYEEAQDAIVKEIVNISSGYVEPMQTLNDVLAQLDAVVSFAHVSNGAPVPYVRPAILEKGQGRII-LKASRHACVEVQDEIAFIPNDVYFEKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDSQLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAFCMFATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFPKHVIECAKQKALELE 852
BLAST of Msh2 vs. Ensembl Celegans
Match: msh-2 (MSH (MutS Homolog) family [Source:UniProtKB/TrEMBL;Acc:Q9TXR4]) HSP 1 Score: 375.555 bits (963), Expect = 2.601e-116 Identity = 287/876 (32.76%), Postives = 452/876 (51.60%), Query Frame = 1
Query: 52 LGDKPNSTIRFFDRQDYYTVHFEDAEMLARSYYKSMEILKYFRRDSVSS---PYINISKSNSDGVFKYLLIANQYKVEVYSNNKSHDSWNLDFVATPGNLEKYQDILFKDVELVSSNSLLGLNIKRINDDYRIFLGFCDLDNGIFMIGGF--EESFTGYEQLANLSSALFQLNCRECLIPNDTRPELLAVKNAVQSAGLLVTEVKK--SFFSSENVMNSILKLICKTKLNNENTVLKLVDTEGAETIG-----CLGSVITYLDLANDESFFNFFDVQTFKLDNYMRVGEQCSRAL-------NILPSPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVA--LRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVK-NHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQ-----LKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLK-DGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFDESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYENLMEWDSNHSEKL---AATRNALM 2586
L K +TI F R +Y++V+ +DA +A + +KS +K F + +S YI++++ + V + ++ + VE+YS+ + W + +PGN ++ +++ + +L + I +DD R+ L D N +I + SF+ EQ +F L E ++ N+ G + + KK S F+ V N +L K++ ++ + L + AE CL I + + A++ S + + + M + AL N L N+L +LY +LN C+T GE+LL W+ +PL ++ IN RLDIVE+L + +R L + L R+PD ++ RRL R K LQD+ + Y A L + +M + + I L S I EILK E F + FFDF+ K N E +V+ D ++E + QME RV++KL + + + LK + ++ G+Y RV+ K+E +R K + I+ET K GVKF +++ +N+ +L+ Y E +I + K +++ + ++ +IA LDV SL+T + G Y RP ++ R+ ++K CRHP++E + +I ND+ D+ R I+TG NMGGKSTY+RS L ++AQIGSFVPC A IS+ D I TR+GA D Q G+STFMAEMLD S IL+ AT S ++IDELGRGTSTFDGFG+A +I++ I ++ S FATHFHE+ L++ V L + Q NE+ +YKV EG A S+G++VAK G+ + I A L E + DS ++L A R A++
Sbjct: 17 LKSKSPNTIAIFSRGEYFSVYGDDATFVATNIFKSDVCVKTFTLSTDNSQQMKYISVNRGQYEKVVRETIVLLRCSVELYSSEQGE--WKMTKRGSPGNTVDFE----QEIGVSDQAPILAIYIHPGDDDNRVTLCAWDAGNVRIVISEYIDTPSFSQTEQ------CIFGLCPTEYILVNE---------------GSVAPKAKKIASMFTRMEVHNK-QQLKPKSQWSDVIESVHLDYKDEAEKQNENIKECLQ--ILHSNAADEYSISEKYSIFNYGTHGNMLIDSCAVEALELFQLNYNYLEKSNNL----TLYNVLNKCKTLPGEKLLRDWLSRPLCQIDHINERLDIVEALFENQTIRQKLRDSILARMPDCSQLARRLMR-KCTLQDLNRFYQAATLLETVEMQLIQLSEAEQFAPSINRLLKSEITEILKKVERFQVLCDEFFDFDYEKENKEIRVRVDFVPEIQEISEKL----EQME----RVAEKLRKKYSAKFECDNLKLDKNSQYGFYFRVTLKEEKSIRKKD-VHILETTKGSGVKFSVGELSDINDEFLEFHLKYTRAEEEVISMLCKKAEEFIPLIPAMAQLIATLDVFVSLSTFAATSSGIYTRPNLLPLGSKRL-ELKQCRHPVIEGNSEKPFIPNDVVLDKCRLI-ILTGANMGGKSTYLRSAALSILLAQIGSFVPCSSATISVVDGIFTRVGASDKQSQGISTFMAEMLDCSAILQRATKNSFVVIDELGRGTSTFDGFGIASAIAQDILNRIQCLSIFATHFHEMGKLAEQPGAV-ALQMGVQIENNEIHMLYKVFEGVAQCSFGLQVAKMVGIDENVINKAAQLLEGLEKKLVIDSKKKKELLESADIRQAIL 845
BLAST of Msh2 vs. Ensembl Celegans
Match: him-14 (MutS protein homolog him-14 [Source:UniProtKB/Swiss-Prot;Acc:Q23405]) HSP 1 Score: 177.563 bits (449), Expect = 1.051e-45 Identity = 154/561 (27.45%), Postives = 262/561 (46.70%), Query Frame = 1
Query: 925 LRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRI---------TRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFT--------SFFDFEAVKNHEFKVKC---------DVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRV---FKVKNCRHPLVEMQNNMSYIANDISFDESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNE------LIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAK 2502
+++ +L +LN T +G RLL + QP DV LI +R + +E LI +L+ L L R +L R+ + ++ ++ + I KL L+ + LL H+ K I E + E LKD F Q+ S D + H KC +D + + E +++ ET + +++ S+ +L F S +Y V+R+ E+V + F+ + + V F+S ++ N+ Q + I+ ++++ + L+ ++ +D LC LAT + D CK F + RHP+++ ++ I ND R F IITGPNM GKSTY++ +++MAQIG F+P + A + IF+RI +R+G D + S F +EM D + I++ A SL+++DEL R TST +G + ++I E + +L++++ ATHF ++ L+ ++N H QT N L Y+ GP YG E+ + S +PDE I+ A+
Sbjct: 233 MKQKRTLMSVLNHTVTTNGYRLLRSSVLQPSTDVYLIQSRQEAIEELIGKPQLKDKL-RRTLSRAHELDRVIAMCIQTSTSWTVRESEAKINQIIKLMHTLKVIQGIRTLL--HSAKMKSNILIEKT----EFLKDP-RFDQIMNILVEKVDDSLLDGKKNSLHLQNTKCYAIRHFVAVQLDLARQTYEE---IIRNVEETGAREIAEYFHGNSSVRLSFSQSRGF-HYTFVTRQAESVTIPRYFLDVFRN-RTTVTFNSRKVIAYNDRLEQVVAEMFLASDVIVCDMIEEMQPMIPVLYYAMDALSSIDFLCGLATY----------SDLRDTCKPTFGPSFSISQGRHPILDWDDSEKTITNDTCLTRDRRFGIITGPNMAGKSTYLKQTAQLAIMAQIGCFIPANYASLPIFNRIFSRMGHNDELIRNKSAFASEMSDAAAIVQYADKNSLVVLDELARSTSTEEGIAITYAICEKV-LKLQSYTFLATHFLDIAALANYSNAIDNYHFLPQTDENSTKKHKLLRGQYR---GPL---YGFELVELSTIPDEVIEHAQ 763
BLAST of Msh2 vs. Ensembl Celegans
Match: msh-6 (MSH (MutS Homolog) family [Source:UniProtKB/TrEMBL;Acc:Q9N3T8]) HSP 1 Score: 175.637 bits (444), Expect = 1.018e-44 Identity = 162/591 (27.41%), Postives = 269/591 (45.52%), Query Frame = 1
Query: 898 LNILPSPNDLRKH-DSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLIN-DNKLRGCLYEENLRRIPDLQRITRRLQ------RN--------------KGNLQDIYKLYVALRQASDMLNLLNEHNGPY--------KCIIQSELSSVIQEILKDTENFIQMFTSFFDFE-AVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQL----SSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQN------NMSYIANDISFDESRT-FQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHV--------TAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEY 2520
LNI+P+ D H SLY ++N C T G RLL W+ QP D + R ++ L++ D L++IPDL R+ +++ R+ K N + I +L A+ D L N+ Y C + EL QE+ + EN I F FD A+K+ + DE E N + +++ V+ K +KF S + Y + + EN + SF +++ + G +ST + E + E+ + + ++ + + G + + +++ DVL SLA +P P+ + V HP + +Q+ S+IAN + S ++TGPNMGGKST +R +++++A IGS VP ++ DRI TRIGA D + G STF E+ + +LK AT SL+++DELGRGTSTFDG +A ++ + I+ +L + F+TH+H + D H NV H+ ++ F+Y++E G +SYG AK +G+ + ++ A L+ +++
Sbjct: 581 LNIVPNGRD--SHLTSLYYVINKCSTPFGRRLLRSWLLQPTCDPKKLEQRQKAIKWLVSPDASSFMTTATATLKKIPDLDRLLQKIHTIGLKYRSEKHPDSRAIFFDTIKTNQKKIAELLAAI----DGFKLCNKLRKEYIKVQKEGEGCELLDELLGNEQEMEEVDEN-IYFFEKMFDRSTAMKDGKIVPNAGCDEEYDEALNRVKEALNELNDYKDSVAKKYSC----SIKFVDSGKVKYLLEMP---ENTKVSSSFE--LKSRRKGFIRYSTPDS---EQLVAALDAVEKEKSKLGDDATRRVFEQFGHKNPIWLETVKLVSSFDVLTSLALFAKSSPFEMCMPEFDFNATDPYLIVDKGVHPCLALQSRNEVTQTTSFIANSTTMGASEAAVMLLTGPNMGGKSTLMRQTAVLAILAHIGSMVPAFSMRLTPIDRIFTRIGANDRIMCGESTFFIELKETDIMLKNATKHSLLLVDELGRGTSTFDGTAIASAVLQKISDDLACRTFFSTHYHSICDSFTNHPNVRLAHMKCVVDKENNEDPTMEDVTFLYELESGICPKSYGFYAAKLAGIDHQVVRNAYLESNKF 1152
BLAST of Msh2 vs. Ensembl Celegans
Match: msh-5 (MutS protein homolog 5 [Source:UniProtKB/Swiss-Prot;Acc:Q19272]) HSP 1 Score: 145.206 bits (365), Expect = 4.123e-35 Identity = 148/612 (24.18%), Postives = 276/612 (45.10%), Query Frame = 1
Query: 748 DTEGAETIGCLGSVITYLDLANDESFFNFFD-----------VQTFKLDNYMRVGEQCSRALNILPSPNDLRKH----DSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLIND-NKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQA-SDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVK-NHEFKVKCDVDESLKEC----ENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFD-ESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHI---ATELKAFSAFATHFHELTDLSKIHCNVNNL--HVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLA 2499
D E I G+++ +LD E+ D ++TF L N + + +AL+ILP + +K SLY L++ CR+ G++ L +W + P D + + +R V D N L R+ L + ++ Q L ++ +V+ A ++LN++ + + ++S+L L++ + S +F K V +DE L E EN + L + + E +R LG+ + +G+ + V R + + ++ ++++ + + ++ + + +++ + + + +II + K S+ +L SI +++DVL S + A + P +VD+ V + HP+ + S++ N +S + IITGPN GKS Y++SIG++ ++ IGSFVP A+I I DRI+TR+ D L G+STF ++ ++ L+ AT SL+IIDE G+GT T G L S+ + + ++HFH L + + N+ + G ++ +++++ G S+ + VAK G+P I A
Sbjct: 231 DIEAVNMIRSFGALLLFLD----ETRMGVTDDPLSVTSPIKSIKTFTLGNLVEIDFNTIQALDILPKETENKKTFGQGRSLYQLMDKCRSTVGKKCLRKWFRNPTTDRDDLVSRQKCVHYFKQDWNAEVTAKLSSILGRVKALNSVFQKFQSGTAQLIH-WECFVSTVNALVEILNIIRQTPISKEFPVESDL-------LREVSEIAVIAGSIINFAESKIQGRVTVMNGIDEELDEIRDTYENMPMVLTAIAKQEEAR----LGLPPYSNVACVYIPLVGFVLSVPR--DYGVESQPDMTLLYSTHEDLRVRNATTSRLDDEFGDILMRLIDSQTAIILTLKTRVMKKKRSIIKLLSIASRIDVLISFG--LIAAQNGWNCPALVDEP---VIEAVELYHPISVLVVKKSFVPNQVSSGRDGIKASIITGPNACGKSVYMKSIGIMVFLSHIGSFVPARHAKIGIVDRIVTRMFTVDSVLDGMSTFAKDVEQVALALRKATGNSLVIIDEFGKGTMTEVGLSLLASVMTYWMNRGADRCPHIFLSSHFHALPNYIPLETNIATFLTFTVLREAGGKIKYLFRMTPGLVDCSFALSVAKEEGIPPPVIGRA 819
BLAST of Msh2 vs. Ensembl Celegans
Match: msh-5 (MutS protein homolog 5 [Source:UniProtKB/Swiss-Prot;Acc:Q19272]) HSP 1 Score: 123.635 bits (309), Expect = 1.671e-28 Identity = 82/260 (31.54%), Postives = 134/260 (51.54%), Query Frame = 1
Query: 1738 SLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFD-ESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHI---ATELKAFSAFATHFHELTDLSKIHCNVNNL--HVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLA 2499
S+ +L SI +++DVL S + A + P +VD+ V + HP+ + S++ N +S + IITGPN GKS Y++SIG++ ++ IGSFVP A+I I DRI+TR+ D L G+STF ++ ++ L+ AT SL+IIDE G+GT T G L S+ + + ++HFH L + + N+ + G ++ +++++ G S+ + VAK G+P I A
Sbjct: 119 SIIKLLSIASRIDVLISFG--LIAAQNGWNCPALVDEP---VIEAVELYHPISVLVVKKSFVPNQVSSGRDGIKASIITGPNACGKSVYMKSIGIMVFLSHIGSFVPARHAKIGIVDRIVTRMFTVDSVLDGMSTFAKDVEQVALALRKATGNSLVIIDEFGKGTMTEVGLSLLASVMTYWMNRGADRCPHIFLSSHFHALPNYIPLETNIATFLTFTVLREAGGKIKYLFRMTPGLVDCSFALSVAKEEGIPPPVIGRA 373
BLAST of Msh2 vs. Ensembl Fly
Match: spel1 (gene:FBgn0015546 transcript:FBtr0344018) HSP 1 Score: 512.301 bits (1318), Expect = 1.125e-167 Identity = 315/878 (35.88%), Postives = 501/878 (57.06%), Query Frame = 1
Query: 7 NMDELTNS---FSLFWNSLGDKPNSTIRFFDRQDYYTVH-FEDAEMLARSYYKSMEILKYFRRDSVSSP--YINISKSNSDGVFKYLLIANQYKVEVYSNNKSHDSWNLDFVATPGNLEKYQDILFKDVELVSSNSLLGLNIK-RINDDYRIFLGFCDLDNGIFMIGGF--EESFTGYEQLANLSSALFQLNCRECLIPNDTRPELLAVKNAVQSAGLLVTEVKKSFFSSENVMNSILKLICKTKLNNEN-TVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNILPSPNDLR-----KHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISF--DESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYENLMEWDSNHSEKLAATRNALME 2589
NMD TN+ F F LG+KP +T+RFFD D YTVH +D E++A+ YKS + D ++++SK N + + LL+ Y+VEVY N S W +++ +PGNL +++DILF + E++ NS++ L +K R+ + + ++ F + F ++ FT L + + L +ECL+P+ E AVK + G+++T KKS +++ + +L+ K E+ T LK + + A L + I YLDL ND ++++ L+ ++ + ALNI+P P + S+ G+L+ CRT G RL+ QW+KQPL N++N+R +IV+ L+ L + L+RIPD+ +T++L R K NLQD++++Y + + +L +L+E + I+S + + + LKD QM DFEA++ E+ VK D L E + M L S+ME + S +L ++ Q+K ES LG++ R++ KD++VLR I++ +K GV+F S ++ + + R YEE + SI+EEI+ + Y L L++ +A+LD L S A AP Y RPK++++ R +++ RHP +E+Q ++++IAN + F +E F IITGPNMGGKSTYIRS+G +MA IG+FVPC A IS+ D I+ R+GA D + G+STFM EM++ S I++TAT KSL+IIDELGRGTST++G G+AWSI+EH+A E K F+ FATHFHE+T L++ V N H+ A ++ +Y+V G +S+GI+VA+ + P+ ++ A+ +E+E+ H +K AL+E
Sbjct: 15 NMD--TNARRNFIKFHAKLGEKPATTVRFFDHTDRYTVHGSDDCELVAKIVYKSTAFIGALLPDDKKETLQFVSMSKGNFELAVRELLLVRNYRVEVYVKNSS--DWEIEYRGSPGNLLQFEDILFSNKEVLVGNSIISLLVKLDGGGQRRVGVASVEQNDCKFQLLEFLDDDFFT------ELEATVVLLGPKECLLPS-IEGEYSAVKTLLDRNGVMITMPKKS--GDNDLLQDLNRLLRFAKGQQEDATGLKELQLQLASN--ALKTAIKYLDLVNDAGNLGHYEIKQLDLNRFVHLDSAAVAALNIMPKPGTHPSMPSYRWQSVLGVLDHCRTPQGHRLMGQWVKQPLRSRNILNDRHNIVQCLLESPDTMETLSLDYLKRIPDILMLTKKLMRRKANLQDLFRIYQVILRTPKILKVLHELDN---STIESVICAPFKSFLKDLTGLKQMVEQVVDFEAIERGEYLVKASFDSRLMELQQMMTELYSKMEELQFKCSQELNLDGKNQVKLESVAKLGHHFRITVKDDSVLRKNKNYRIVDVIKGGVRFTSDKLEGYADEFASCRTRYEEQQLSIVEEIIHVAVGYAAPLTLLNNELAQLDCLVSFAIAARSAPTPYVRPKMLEE-GARELVLEDVRHPCLELQEHVNFIANSVDFKKEECNMF-IITGPNMGGKSTYIRSVGTAVLMAHIGAFVPCSLATISMVDSILGRVGASDNIIKGLSTFMVEMIETSGIIRTATDKSLVIIDELGRGTSTYEGCGIAWSIAEHLAKETKCFTLFATHFHEITKLAETLSTVKNCHMAAVADADDFTLLYQVRSGVMEKSFGIQVARLANFPEHVVQNAQEVYNEFED------EHVDKQKKEDKALLE 866
BLAST of Msh2 vs. Ensembl Fly
Match: spel1 (gene:FBgn0015546 transcript:FBtr0344019) HSP 1 Score: 512.301 bits (1318), Expect = 1.125e-167 Identity = 315/878 (35.88%), Postives = 501/878 (57.06%), Query Frame = 1
Query: 7 NMDELTNS---FSLFWNSLGDKPNSTIRFFDRQDYYTVH-FEDAEMLARSYYKSMEILKYFRRDSVSSP--YINISKSNSDGVFKYLLIANQYKVEVYSNNKSHDSWNLDFVATPGNLEKYQDILFKDVELVSSNSLLGLNIK-RINDDYRIFLGFCDLDNGIFMIGGF--EESFTGYEQLANLSSALFQLNCRECLIPNDTRPELLAVKNAVQSAGLLVTEVKKSFFSSENVMNSILKLICKTKLNNEN-TVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNILPSPNDLR-----KHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISF--DESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYENLMEWDSNHSEKLAATRNALME 2589
NMD TN+ F F LG+KP +T+RFFD D YTVH +D E++A+ YKS + D ++++SK N + + LL+ Y+VEVY N S W +++ +PGNL +++DILF + E++ NS++ L +K R+ + + ++ F + F ++ FT L + + L +ECL+P+ E AVK + G+++T KKS +++ + +L+ K E+ T LK + + A L + I YLDL ND ++++ L+ ++ + ALNI+P P + S+ G+L+ CRT G RL+ QW+KQPL N++N+R +IV+ L+ L + L+RIPD+ +T++L R K NLQD++++Y + + +L +L+E + I+S + + + LKD QM DFEA++ E+ VK D L E + M L S+ME + S +L ++ Q+K ES LG++ R++ KD++VLR I++ +K GV+F S ++ + + R YEE + SI+EEI+ + Y L L++ +A+LD L S A AP Y RPK++++ R +++ RHP +E+Q ++++IAN + F +E F IITGPNMGGKSTYIRS+G +MA IG+FVPC A IS+ D I+ R+GA D + G+STFM EM++ S I++TAT KSL+IIDELGRGTST++G G+AWSI+EH+A E K F+ FATHFHE+T L++ V N H+ A ++ +Y+V G +S+GI+VA+ + P+ ++ A+ +E+E+ H +K AL+E
Sbjct: 15 NMD--TNARRNFIKFHAKLGEKPATTVRFFDHTDRYTVHGSDDCELVAKIVYKSTAFIGALLPDDKKETLQFVSMSKGNFELAVRELLLVRNYRVEVYVKNSS--DWEIEYRGSPGNLLQFEDILFSNKEVLVGNSIISLLVKLDGGGQRRVGVASVEQNDCKFQLLEFLDDDFFT------ELEATVVLLGPKECLLPS-IEGEYSAVKTLLDRNGVMITMPKKS--GDNDLLQDLNRLLRFAKGQQEDATGLKELQLQLASN--ALKTAIKYLDLVNDAGNLGHYEIKQLDLNRFVHLDSAAVAALNIMPKPGTHPSMPSYRWQSVLGVLDHCRTPQGHRLMGQWVKQPLRSRNILNDRHNIVQCLLESPDTMETLSLDYLKRIPDILMLTKKLMRRKANLQDLFRIYQVILRTPKILKVLHELDN---STIESVICAPFKSFLKDLTGLKQMVEQVVDFEAIERGEYLVKASFDSRLMELQQMMTELYSKMEELQFKCSQELNLDGKNQVKLESVAKLGHHFRITVKDDSVLRKNKNYRIVDVIKGGVRFTSDKLEGYADEFASCRTRYEEQQLSIVEEIIHVAVGYAAPLTLLNNELAQLDCLVSFAIAARSAPTPYVRPKMLEE-GARELVLEDVRHPCLELQEHVNFIANSVDFKKEECNMF-IITGPNMGGKSTYIRSVGTAVLMAHIGAFVPCSLATISMVDSILGRVGASDNIIKGLSTFMVEMIETSGIIRTATDKSLVIIDELGRGTSTYEGCGIAWSIAEHLAKETKCFTLFATHFHEITKLAETLSTVKNCHMAAVADADDFTLLYQVRSGVMEKSFGIQVARLANFPEHVVQNAQEVYNEFED------EHVDKQKKEDKALLE 866
BLAST of Msh2 vs. Ensembl Fly
Match: spel1 (gene:FBgn0015546 transcript:FBtr0080630) HSP 1 Score: 512.301 bits (1318), Expect = 1.125e-167 Identity = 315/878 (35.88%), Postives = 501/878 (57.06%), Query Frame = 1
Query: 7 NMDELTNS---FSLFWNSLGDKPNSTIRFFDRQDYYTVH-FEDAEMLARSYYKSMEILKYFRRDSVSSP--YINISKSNSDGVFKYLLIANQYKVEVYSNNKSHDSWNLDFVATPGNLEKYQDILFKDVELVSSNSLLGLNIK-RINDDYRIFLGFCDLDNGIFMIGGF--EESFTGYEQLANLSSALFQLNCRECLIPNDTRPELLAVKNAVQSAGLLVTEVKKSFFSSENVMNSILKLICKTKLNNEN-TVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNILPSPNDLR-----KHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISF--DESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYENLMEWDSNHSEKLAATRNALME 2589
NMD TN+ F F LG+KP +T+RFFD D YTVH +D E++A+ YKS + D ++++SK N + + LL+ Y+VEVY N S W +++ +PGNL +++DILF + E++ NS++ L +K R+ + + ++ F + F ++ FT L + + L +ECL+P+ E AVK + G+++T KKS +++ + +L+ K E+ T LK + + A L + I YLDL ND ++++ L+ ++ + ALNI+P P + S+ G+L+ CRT G RL+ QW+KQPL N++N+R +IV+ L+ L + L+RIPD+ +T++L R K NLQD++++Y + + +L +L+E + I+S + + + LKD QM DFEA++ E+ VK D L E + M L S+ME + S +L ++ Q+K ES LG++ R++ KD++VLR I++ +K GV+F S ++ + + R YEE + SI+EEI+ + Y L L++ +A+LD L S A AP Y RPK++++ R +++ RHP +E+Q ++++IAN + F +E F IITGPNMGGKSTYIRS+G +MA IG+FVPC A IS+ D I+ R+GA D + G+STFM EM++ S I++TAT KSL+IIDELGRGTST++G G+AWSI+EH+A E K F+ FATHFHE+T L++ V N H+ A ++ +Y+V G +S+GI+VA+ + P+ ++ A+ +E+E+ H +K AL+E
Sbjct: 15 NMD--TNARRNFIKFHAKLGEKPATTVRFFDHTDRYTVHGSDDCELVAKIVYKSTAFIGALLPDDKKETLQFVSMSKGNFELAVRELLLVRNYRVEVYVKNSS--DWEIEYRGSPGNLLQFEDILFSNKEVLVGNSIISLLVKLDGGGQRRVGVASVEQNDCKFQLLEFLDDDFFT------ELEATVVLLGPKECLLPS-IEGEYSAVKTLLDRNGVMITMPKKS--GDNDLLQDLNRLLRFAKGQQEDATGLKELQLQLASN--ALKTAIKYLDLVNDAGNLGHYEIKQLDLNRFVHLDSAAVAALNIMPKPGTHPSMPSYRWQSVLGVLDHCRTPQGHRLMGQWVKQPLRSRNILNDRHNIVQCLLESPDTMETLSLDYLKRIPDILMLTKKLMRRKANLQDLFRIYQVILRTPKILKVLHELDN---STIESVICAPFKSFLKDLTGLKQMVEQVVDFEAIERGEYLVKASFDSRLMELQQMMTELYSKMEELQFKCSQELNLDGKNQVKLESVAKLGHHFRITVKDDSVLRKNKNYRIVDVIKGGVRFTSDKLEGYADEFASCRTRYEEQQLSIVEEIIHVAVGYAAPLTLLNNELAQLDCLVSFAIAARSAPTPYVRPKMLEE-GARELVLEDVRHPCLELQEHVNFIANSVDFKKEECNMF-IITGPNMGGKSTYIRSVGTAVLMAHIGAFVPCSLATISMVDSILGRVGASDNIIKGLSTFMVEMIETSGIIRTATDKSLVIIDELGRGTSTYEGCGIAWSIAEHLAKETKCFTLFATHFHEITKLAETLSTVKNCHMAAVADADDFTLLYQVRSGVMEKSFGIQVARLANFPEHVVQNAQEVYNEFED------EHVDKQKKEDKALLE 866
BLAST of Msh2 vs. Ensembl Fly
Match: spel1 (gene:FBgn0015546 transcript:FBtr0309281) HSP 1 Score: 512.301 bits (1318), Expect = 1.125e-167 Identity = 315/878 (35.88%), Postives = 501/878 (57.06%), Query Frame = 1
Query: 7 NMDELTNS---FSLFWNSLGDKPNSTIRFFDRQDYYTVH-FEDAEMLARSYYKSMEILKYFRRDSVSSP--YINISKSNSDGVFKYLLIANQYKVEVYSNNKSHDSWNLDFVATPGNLEKYQDILFKDVELVSSNSLLGLNIK-RINDDYRIFLGFCDLDNGIFMIGGF--EESFTGYEQLANLSSALFQLNCRECLIPNDTRPELLAVKNAVQSAGLLVTEVKKSFFSSENVMNSILKLICKTKLNNEN-TVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNILPSPNDLR-----KHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISF--DESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYENLMEWDSNHSEKLAATRNALME 2589
NMD TN+ F F LG+KP +T+RFFD D YTVH +D E++A+ YKS + D ++++SK N + + LL+ Y+VEVY N S W +++ +PGNL +++DILF + E++ NS++ L +K R+ + + ++ F + F ++ FT L + + L +ECL+P+ E AVK + G+++T KKS +++ + +L+ K E+ T LK + + A L + I YLDL ND ++++ L+ ++ + ALNI+P P + S+ G+L+ CRT G RL+ QW+KQPL N++N+R +IV+ L+ L + L+RIPD+ +T++L R K NLQD++++Y + + +L +L+E + I+S + + + LKD QM DFEA++ E+ VK D L E + M L S+ME + S +L ++ Q+K ES LG++ R++ KD++VLR I++ +K GV+F S ++ + + R YEE + SI+EEI+ + Y L L++ +A+LD L S A AP Y RPK++++ R +++ RHP +E+Q ++++IAN + F +E F IITGPNMGGKSTYIRS+G +MA IG+FVPC A IS+ D I+ R+GA D + G+STFM EM++ S I++TAT KSL+IIDELGRGTST++G G+AWSI+EH+A E K F+ FATHFHE+T L++ V N H+ A ++ +Y+V G +S+GI+VA+ + P+ ++ A+ +E+E+ H +K AL+E
Sbjct: 15 NMD--TNARRNFIKFHAKLGEKPATTVRFFDHTDRYTVHGSDDCELVAKIVYKSTAFIGALLPDDKKETLQFVSMSKGNFELAVRELLLVRNYRVEVYVKNSS--DWEIEYRGSPGNLLQFEDILFSNKEVLVGNSIISLLVKLDGGGQRRVGVASVEQNDCKFQLLEFLDDDFFT------ELEATVVLLGPKECLLPS-IEGEYSAVKTLLDRNGVMITMPKKS--GDNDLLQDLNRLLRFAKGQQEDATGLKELQLQLASN--ALKTAIKYLDLVNDAGNLGHYEIKQLDLNRFVHLDSAAVAALNIMPKPGTHPSMPSYRWQSVLGVLDHCRTPQGHRLMGQWVKQPLRSRNILNDRHNIVQCLLESPDTMETLSLDYLKRIPDILMLTKKLMRRKANLQDLFRIYQVILRTPKILKVLHELDN---STIESVICAPFKSFLKDLTGLKQMVEQVVDFEAIERGEYLVKASFDSRLMELQQMMTELYSKMEELQFKCSQELNLDGKNQVKLESVAKLGHHFRITVKDDSVLRKNKNYRIVDVIKGGVRFTSDKLEGYADEFASCRTRYEEQQLSIVEEIIHVAVGYAAPLTLLNNELAQLDCLVSFAIAARSAPTPYVRPKMLEE-GARELVLEDVRHPCLELQEHVNFIANSVDFKKEECNMF-IITGPNMGGKSTYIRSVGTAVLMAHIGAFVPCSLATISMVDSILGRVGASDNIIKGLSTFMVEMIETSGIIRTATDKSLVIIDELGRGTSTYEGCGIAWSIAEHLAKETKCFTLFATHFHEITKLAETLSTVKNCHMAAVADADDFTLLYQVRSGVMEKSFGIQVARLANFPEHVVQNAQEVYNEFED------EHVDKQKKEDKALLE 866
BLAST of Msh2 vs. Ensembl Fly
Match: Msh6 (gene:FBgn0036486 transcript:FBtr0075646) HSP 1 Score: 170.244 bits (430), Expect = 6.514e-43 Identity = 104/273 (38.10%), Postives = 145/273 (53.11%), Query Frame = 1
Query: 1714 KITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFDESR--TFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTD---------LSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLA 2499
K +N Y Q +A LDVL SLA G P++V D +++ HP N +YI N + + ++TGPNMGGKST +R +GL+ +MAQIG+ +P +S+ DRI TR+GA D L G STF+ E+ + S ILK AT SL+++DELGRGT+T+DG +A S+ +A LK + F+TH+H L D L + C V N A + F+YK G +SYG AK +G+P IK A
Sbjct: 875 KFSNHY-DQWKQCIDCVANLDVLGSLAEYA-GQQMVICVPELVSDADQPFIQLEEGYHPCA---NASTYIPNGLELGTASEAPLSLLTGPNMGGKSTLMREVGLLVIMAQIGAHIPAASCRLSLVDRIFTRLGAQDDILAGHSTFLVELNETSLILKHATCHSLVLLDELGRGTATYDGTAIAASVVNFLAN-LKCRTLFSTHYHNLIDFFHNDKRITLGHMACMVEN-EDNADPTQETVTFLYKYTAGACPKSYGFNAAKLAGMPQGIIKRA 1140
BLAST of Msh2 vs. Ensembl Zebrafish
Match: msh2 (mutS homolog 2 (E. coli) [Source:ZFIN;Acc:ZDB-GENE-040426-2932]) HSP 1 Score: 625.165 bits (1611), Expect = 0.000e+0 Identity = 346/873 (39.63%), Postives = 538/873 (61.63%), Query Frame = 1
Query: 1 N*NMDELT-NSFSLFWNSLGDKPNSTIRFFDRQDYYTVHFEDAEMLARSYYKSMEILKYFRRDSVSSPYINISKSNSDGVFKYLLIANQYKVEVYSN----NKSHDSWNLDFVATPGNLEKYQDILFKDVELVSSNSL--LGLNIKRINDDYRIFLGFCDLDNGIFMIGGFEESFTGYEQLANLSSALFQLNCRECLIP-NDTRPELLAVKNAVQSAGLLVTEVKKSFFSSENVMNSILKLICKTKLNNENTVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNILP-SPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFDES-RTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYENLMEWDSNHSEKLAATRNALME 2589
N +MD + + F F+ S+ DKP++T+R FDR DYYTVH +DA A+ +K+ ++K + + +SK N + + LL+ QY+VEVY N +K HD W + F A+PGNL ++++ILF + ++ +G+ + D R+ +G +D+ + +G E F +Q +NL + L Q+ +EC++P D+ +L +K VQ G+L+T+ KKS F++++++ + +L+ K + + L + E + CL +VI YL+L DE+ F F + TF L+ YMR+ +ALN+ S +D SL GLLN CRT G+RL+ QWIKQPL+D N I RLD+VE+ + D++LR E+ LRR PDL R+ ++ QR NLQD Y++Y ++ Q +++ L ++G ++ ++ + S + +++ D F +M + D V++HEF VK D +L + +M L+ M+ S + +LG+E+ K +K ES+ +GY+ RV+ K+E LRN + ++ K+GV+F +++++ +NE Y + R +YEE + +I++EI+ I YV + L+ +IA+LD + S A + AP + RPK+++ R+ +K RHP VE Q+ +++I ND++F + F IITGPNMGGKSTYIR +G+I +MAQIG FVPCD AE+S+ D ++ R+GAGD Q+ GVSTFMAEML+ + IL++A+ SLIIIDELGRGTST+DGFGLAW+ISE+IAT LK+F FATHFHELT L++ V NLHVTA T + L +YKV++G +S+GI VA+ + P I A+ K E E + S E + ME
Sbjct: 8 NLSMDSASEHGFLNFYFSMSDKPDTTVRVFDRNDYYTVHGKDAIFAAKEVFKTNGVIKNLGSGNRRLESVVLSKMNFESFVRDLLLVRQYRVEVYKNASKSSKEHD-WQIAFKASPGNLTQFEEILFGSGGGPAEGAVGVVGVRLGTGTDGQRV-VGVGYVDSTLRKLGVCE--FPDNDQFSNLEALLVQIGPKECVLPAGDSGGDLGKLKQVVQRGGILLTDRKKSEFTTKDIVQDLNRLL-KARKGETVSSAALPEMEKKIAMSCLEAVIKYLELLADEANFGSFKMTTFDLNQYMRLDNAAVQALNLFQGSSDDATGTHSLAGLLNKCRTPQGQRLVNQWIKQPLIDKNKIEERLDLVETFVEDSELRKSCQEDLLRRFPDLNRMAKKFQRQSSNLQDCYRVYQSVGQLPNVVLALERYSGKHQVLLHAAFISPLNDLISDFSKFQEMIETTLDMNQVEHHEFLVKPSFDPTLSDLRENMDRLEKAMQAALSSAARELGLEAAKTVKLESNAQIGYFFRVTCKEEKSLRNNKKFTTLDVQKNGVRFTNSKLSSLNEEYTKSREEYEEAQNAIVKEIISIAAGYVDPVQTLNEVIAQLDAVVSFAVVSHAAPVPFIRPKILEKGSGRLV-LKAARHPCVEAQDEVAFIPNDVTFIRGEKMFHIITGPNMGGKSTYIRQVGVIVLMAQIGCFVPCDEAELSVVDCVLARVGAGDSQIKGVSTFMAEMLETAAILRSASEDSLIIIDELGRGTSTYDGFGLAWAISEYIATRLKSFCLFATHFHELTALAQQVPTVRNLHVTALTTDSTLTMLYKVKKGVCDQSFGIHVAELASFPKHVIANAREKALELEEFQDISSVGEEAGPKAKKRCME 874
BLAST of Msh2 vs. Ensembl Zebrafish
Match: msh2 (mutS homolog 2 (E. coli) [Source:ZFIN;Acc:ZDB-GENE-040426-2932]) HSP 1 Score: 625.165 bits (1611), Expect = 0.000e+0 Identity = 346/873 (39.63%), Postives = 538/873 (61.63%), Query Frame = 1
Query: 1 N*NMDELT-NSFSLFWNSLGDKPNSTIRFFDRQDYYTVHFEDAEMLARSYYKSMEILKYFRRDSVSSPYINISKSNSDGVFKYLLIANQYKVEVYSN----NKSHDSWNLDFVATPGNLEKYQDILFKDVELVSSNSL--LGLNIKRINDDYRIFLGFCDLDNGIFMIGGFEESFTGYEQLANLSSALFQLNCRECLIP-NDTRPELLAVKNAVQSAGLLVTEVKKSFFSSENVMNSILKLICKTKLNNENTVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNILP-SPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFDES-RTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYENLMEWDSNHSEKLAATRNALME 2589
N +MD + + F F+ S+ DKP++T+R FDR DYYTVH +DA A+ +K+ ++K + + +SK N + + LL+ QY+VEVY N +K HD W + F A+PGNL ++++ILF + ++ +G+ + D R+ +G +D+ + +G E F +Q +NL + L Q+ +EC++P D+ +L +K VQ G+L+T+ KKS F++++++ + +L+ K + + L + E + CL +VI YL+L DE+ F F + TF L+ YMR+ +ALN+ S +D SL GLLN CRT G+RL+ QWIKQPL+D N I RLD+VE+ + D++LR E+ LRR PDL R+ ++ QR NLQD Y++Y ++ Q +++ L ++G ++ ++ + S + +++ D F +M + D V++HEF VK D +L + +M L+ M+ S + +LG+E+ K +K ES+ +GY+ RV+ K+E LRN + ++ K+GV+F +++++ +NE Y + R +YEE + +I++EI+ I YV + L+ +IA+LD + S A + AP + RPK+++ R+ +K RHP VE Q+ +++I ND++F + F IITGPNMGGKSTYIR +G+I +MAQIG FVPCD AE+S+ D ++ R+GAGD Q+ GVSTFMAEML+ + IL++A+ SLIIIDELGRGTST+DGFGLAW+ISE+IAT LK+F FATHFHELT L++ V NLHVTA T + L +YKV++G +S+GI VA+ + P I A+ K E E + S E + ME
Sbjct: 8 NLSMDSASEHGFLNFYFSMSDKPDTTVRVFDRNDYYTVHGKDAIFAAKEVFKTNGVIKNLGSGNRRLESVVLSKMNFESFVRDLLLVRQYRVEVYKNASKSSKEHD-WQIAFKASPGNLTQFEEILFGSGGGPAEGAVGVVGVRLGTGTDGQRV-VGVGYVDSTLRKLGVCE--FPDNDQFSNLEALLVQIGPKECVLPAGDSGGDLGKLKQVVQRGGILLTDRKKSEFTTKDIVQDLNRLL-KARKGETVSSAALPEMEKKIAMSCLEAVIKYLELLADEANFGSFKMTTFDLNQYMRLDNAAVQALNLFQGSSDDATGTHSLAGLLNKCRTPQGQRLVNQWIKQPLIDKNKIEERLDLVETFVEDSELRKSCQEDLLRRFPDLNRMAKKFQRQSSNLQDCYRVYQSVGQLPNVVLALERYSGKHQVLLHAAFISPLNDLISDFSKFQEMIETTLDMNQVEHHEFLVKPSFDPTLSDLRENMDRLEKAMQAALSSAARELGLEAAKTVKLESNAQIGYFFRVTCKEEKSLRNNKKFTTLDVQKNGVRFTNSKLSSLNEEYTKSREEYEEAQNAIVKEIISIAAGYVDPVQTLNEVIAQLDAVVSFAVVSHAAPVPFIRPKILEKGSGRLV-LKAARHPCVEAQDEVAFIPNDVTFIRGEKMFHIITGPNMGGKSTYIRQVGVIVLMAQIGCFVPCDEAELSVVDCVLARVGAGDSQIKGVSTFMAEMLETAAILRSASEDSLIIIDELGRGTSTYDGFGLAWAISEYIATRLKSFCLFATHFHELTALAQQVPTVRNLHVTALTTDSTLTMLYKVKKGVCDQSFGIHVAELASFPKHVIANAREKALELEEFQDISSVGEEAGPKAKKRCME 874
BLAST of Msh2 vs. Ensembl Zebrafish
Match: msh4 (mutS homolog 4 [Source:ZFIN;Acc:ZDB-GENE-131121-643]) HSP 1 Score: 211.075 bits (536), Expect = 2.406e-56 Identity = 172/582 (29.55%), Postives = 291/582 (50.00%), Query Frame = 1
Query: 928 RKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYE------------ENLRRIPDLQ-------RITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHE--FKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNK---SFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFDESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTI------GNELIFMYKVEEGPA-VRSYGIEVAKASGLPDESIKLAKLKLSEYENLMEWDSNHSEKLAATRNA 2580
R +L+G+LN +T+ GER L I +PL++V+ I +R D ++ L+ + +L L L +IP + +IT+ +Q L+ I +L +L+ ML H C +S IL ++ I TS+ + + V+ +V E L + +++ + + + +LG + L+ SN+ G+++++ + + K FI + + K+ F + + MN+ + +D ++ +++ ++ + L++LS +++ LD+L SLA C Y RP+ D ++ RHP++E + I+N+ E F IITGPNM GKST+++ + L+ +MAQIG FVP + A + I D+I TRIG D T STFM EM ++S+I+ AT+ SLIIIDELGRGTS +G G+ S+ E + LKAF+ FATHF EL L ++ NV N H+ Q I +++ Y++ G + R+YGI A+ + LP + I+ AK +++ N W +HS+ + A
Sbjct: 322 RSEHTLFGVLNHTKTSGGERRLRSNILEPLLEVDTIKSRQDTIQELLQNEELFFSLKNAIAHFLDIDELLSALVQIPKQETIAVAEAKITQVIQ-----LKHIVELVPSLKV---MLQHSTTHLLTAYC--KSLEDCRFNSILDHIKSLINDDTSYMKGSLTMRTQKCYAVRPNVSEFLDIARRAY----TEVVDDIAGLVAQLGEKHNLPLRTSFSNARGFFIQMKLEGGALPGGKLPDEFIKVSKQ-KNNFSFTTLDLMKMNDHCEEALKDIFHMSYVVVSKLLNEVHEQIHCLYKLSDVVSMLDMLLSLAN-ACTI-SNYVRPEFTD-----TLAIQQGRHPVLERISGQQPISNNSYISEGSNFVIITGPNMSGKSTFLKQVALVQIMAQIGCFVPAEYASVRIADQIFTRIGVDDDFETNSSTFMVEMKEVSYIIHNATNSSLIIIDELGRGTSPEEGIGICHSVCEFL-INLKAFTLFATHFLELCQLQTLYPNVENQHMQVQHIRTGDGRAERVVYTYQLSRGHSEERNYGIRAAEMTNLPLDIIQEAK-TVADKINQKLWAKHHSDPATLKQRA 879
BLAST of Msh2 vs. Ensembl Zebrafish
Match: msh3 (mutS homolog 3 (E. coli) [Source:ZFIN;Acc:ZDB-GENE-060526-307]) HSP 1 Score: 209.92 bits (533), Expect = 1.253e-55 Identity = 204/737 (27.68%), Postives = 344/737 (46.68%), Query Frame = 1
Query: 469 GIFMIGGFEESFTGYEQLANLSSALFQLNCRECLIPND---TRPELLA--VKNAVQSAGLLVTEVKKSFFSSENVMNSILKLICK-----TKLNNENTVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKL----DNYMRVGEQCSRALNILPSPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSS-VIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQM--------TLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSS---IIAKLDVLCSLATMVC-------GAPGTYARPKVVDDCKTRVFKVKNCRHPLVE--MQNNMSYIANDISFD-ESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHC-NVNNLHVT-----AQTIGNE-------LIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYENLM 2532
G M+ F+++ + E L S + ++ E L+P+D T LL ++VQ+ + E ++S SI+K + N+E + + I CLG VI YL E +FK ++M + + L IL + SL +L+ +T G+RLL +W+ QPL V I R + V +++ + L R+PDL+R + + + Q+ Y + +L + + L L IQS+LSS +++ +L DT Q+ + +F V N + + E + + + K++ E ES + +E ++++ N Y VS + + S +SI+ D VK ST++ + LQ R+ + ++++ L I+ K +C LATM C Y RP+V+++ K+++ + +HP++ M + Y+ ND + + IITGPNMGGKS+YIR + L+++MAQ+GSFVP A + I D I R+GA D G STFM E+L+ S +L ATS+SL+I+DELGRGTST DG +A++ E E++ + F TH+ L +L ++ +V N H+ ++ +E + F+Y++ EG A RSYG+ VA+ + +P+ ++ A K E E L+
Sbjct: 353 GDVMVDCFKDNMSHSE----LESRILRIQPVEILVPSDLSETTERLLRNIALSSVQADDRIRIEKRESAMFEYPTALSIIKDFYRGGPHSAARNHEKGSYSICMGLESPIICCLGPVIQYLTEFKLEKIL--LCSSSFKRLSSDPDHMLLSAATMKNLEILCNQTTGSVKGSLLWVLDHTQTLFGKRLLRKWVSQPLKSVIDIQARQEAVAEILSSESSVLPSIQSLLTRLPDLERGLCSIYHKRCSTQEFYLIISSLSRLNVELQALMP-------AIQSQLSSPLLKTLLLDTP---QLLSPAHNFLKVLNEKAAKTGNKTEMFVDLTDFPVIRKTKEEIESVLLDI---MEHRREVRLLLKNPSLDYTTVSGQQFLIEVKNSMLSIVPA--DWVKISSTKVFGRYHTPFIVEKHRRLQQLREQLV---------IDCNHEWINFLQLFGDHYYILRK--AVCHLATMDCLFSLAQVAKENNYCRPEVLEE-KSQIL-ITAGKHPVITSLMGDQDQYVPNDTHLQGDGKRAMIITGPNMGGKSSYIRQVALVTIMAQLGSFVPAREASVGIVDGIYVRMGASDNISRGRSTFMEELLETSDVLACATSRSLVILDELGRGTSTHDGIAIAYATLESFIREVRCMTLFVTHYPPLCELEHLYPQHVGNYHMAFLLNEPESTSDEEEAQPEFITFLYQLIEGAAARSYGLNVARLAEIPESILRTAAFKSKELEALV 1055
BLAST of Msh2 vs. Ensembl Zebrafish
Match: msh3 (mutS homolog 3 (E. coli) [Source:ZFIN;Acc:ZDB-GENE-060526-307]) HSP 1 Score: 204.912 bits (520), Expect = 5.688e-54 Identity = 204/738 (27.64%), Postives = 345/738 (46.75%), Query Frame = 1
Query: 469 GIFMIGGFEESFTGYEQLANLSSALFQLNCRECLIPND---TRPELLA--VKNAVQSAGLLVTEVKKSFFSSENVMNSILKLICK-----TKLNNENTVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKL----DNYMRVGEQCSRALNILPSPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIY---KLYVALRQASDMLNLLNEHNGPYKCIIQSELSS-VIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQM------TLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSS---IIAKLDVLCSLATMVC-------GAPGTYARPKVVDDCKTRVFKVKNCRHPLVE--MQNNMSYIANDISFD-ESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHC-NVNNLHVT-----AQTIGNE-------LIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYENLM 2532
G M+ F+++ + E L S + ++ E L+P+D T LL ++VQ+ + E ++S SI+K + N+E + + I CLG VI YL E +FK ++M + + L IL + SL +L+ +T G+RLL +W+ QPL V I R + V +++ + L R+PDL+R L IY + Y+ + L+ LN IQS+LSS +++ +L DT Q+ + +F V N + + E + + + K++ E ES + +E ++++ N Y VS + + S +SI+ D VK ST++ + E + + ++ + ++ ++++ L I+ K +C LATM C Y RP+V+++ K+++ + +HP++ M + Y+ ND + + IITGPNMGGKS+YIR + L+++MAQ+GSFVP A + I D I R+GA D G STFM E+L+ S +L ATS+SL+I+DELGRGTST DG +A++ E E++ + F TH+ L +L ++ +V N H+ ++ +E + F+Y++ EG A RSYG+ VA+ + +P+ ++ A K E E L+
Sbjct: 353 GDVMVDCFKDNMSHSE----LESRILRIQPVEILVPSDLSETTERLLRNIALSSVQADDRIRIEKRESAMFEYPTALSIIKDFYRGGPHSAARNHEKGSYSICMGLESPIICCLGPVIQYLTEFKLEKIL--LCSSSFKRLSSDPDHMLLSAATMKNLEILCNQTTGSVKGSLLWVLDHTQTLFGKRLLRKWVSQPLKSVIDIQARQEAVAEILSSESSVLPSIQSLLTRLPDLER----------GLCSIYHKREFYLIISS----LSRLNVELQALMPAIQSQLSSPLLKTLLLDTP---QLLSPAHNFLKVLNEKAAKTGNKTEMFVDLTDFPVIRKTKEEIESVLLDI---MEHRREVRLLLKNPSLDYTTVSGQQFLIEVKNSMLSIVPA--DWVKISSTKVFGRYHTPFIVEKHRR-------LQQLREQLVIDCNHEWINFLQLFGDHYYILRK--AVCHLATMDCLFSLAQVAKENNYCRPEVLEE-KSQIL-ITAGKHPVITSLMGDQDQYVPNDTHLQGDGKRAMIITGPNMGGKSSYIRQVALVTIMAQLGSFVPAREASVGIVDGIYVRMGASDNISRGRSTFMEELLETSDVLACATSRSLVILDELGRGTSTHDGIAIAYATLESFIREVRCMTLFVTHYPPLCELEHLYPQHVGNYHMAFLLNEPESTSDEEEAQPEFITFLYQLIEGAAARSYGLNVARLAEIPESILRTAAFKSKELEALV 1051
BLAST of Msh2 vs. Ensembl Xenopus
Match: MSH2 (mutS homolog 2 [Source:NCBI gene;Acc:100380043]) HSP 1 Score: 645.58 bits (1664), Expect = 0.000e+0 Identity = 349/868 (40.21%), Postives = 543/868 (62.56%), Query Frame = 1
Query: 25 NSFSLFWNSLGDKPNSTIRFFDRQDYYTVHFEDAEMLARSYYKSMEILKYFRRDSVSSPYINISKSNSDGVFKYLLIANQYKVEVYSNNKSHDS-----WNLDFVATPGNLEKYQDILFKDVELVSSNSLLGLNIKRINDDYRIFLGFCDLDNGIFMIGGFEESFTGYEQLANLSSALFQLNCRECLIPN-DTRPELLAVKNAVQSAGLLVTEVKKSFFSSENVMNSILKLICKTKLNNENTVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNILP-SPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFD-ESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAK---LKLSEYENLMEWDSNHSEKLAATRNALMEFC 2595
N F F+ S+ +KP++T+R FDR DYYTVH DA A+ +K+ ++KY + + +SK N + V K LL+ QY+VEVY N S W L F A+PGNL ++++ILF + ++ ++ ++G IK ++ + + +G +D+ + +G E F +Q +NL + L Q+ +EC++P DT ++ ++ V+ G+L+T+ KK+ F++++ + + +L+ K K + T L + E + L SV+ YL+L +DES F F + F L YM++ ALN+ P S D SL GLLN C+T G+RL+ QWIKQPLMD N I RL++VE+ + D +LR CL E+ LRR PDL R+ ++ QR NLQD Y+LY A+ Q ++ + ++ G ++ ++ + ++ + ++ D F +M + D + V+NHEF VK D +L E M L+ M+ + + +LG+++ K +K ES++ +G++ RV+ K+E LRN + I+ K+GV+F + +++ ++E Y+++R +YEE + +I++EI+ I+ YV + L+ +IA+LD S A + AP Y RP +++ + ++ +++ RHP +EMQ+++++I NDI+F+ E + F IITGPNMGGKSTYIR G+I +MAQIGSFVPCD AEISI D I+ R+GAGD QL GVSTFMAEML+ + IL++AT SLIIIDELGRGTST+DGFGLAW+ISE+I+T++KAF FATHFHELT L+ VNNLHVTA T + L +Y+++ G +S+GI VA+ + P I+ AK L+L E++ + D E R E C
Sbjct: 17 NGFISFYQSMPEKPDTTVRVFDRNDYYTVHGGDAIFAAKEVFKTNGVIKYLGSGASKLESVVLSKMNFESVVKDLLLVRQYRVEVYKNKSGGKSSKENDWQLAFKASPGNLTQFEEILFGNSDMSTAVGVVG--IKLVSAEGQRLVGVGYVDSTLRKLGVCE--FPDNDQFSNLEALLVQIGPKECVMPGGDTAGDMGKLRQIVKRGGILITDRKKAEFTTKDSVQDLNRLL-KAKKGEQVTSAALPEMEKQVAMSALASVMKYLELLSDESNFGQFVMTNFDLSQYMKLDNAAVGALNLFPGSAEDTSGTQSLAGLLNKCKTPQGQRLVNQWIKQPLMDKNRIEERLNLVEAFVTDAELRQCLQEDLLRRFPDLNRLAKKFQRQTANLQDCYRLYQAVNQLPGVIQAIEKYEGTHQMLLLAVFATPLSDLSSDFSKFQEMIETTLDMDQVENHEFLVKASFDPNLTELREKMNELEKNMQAALNGAARELGLDAGKSIKLESNSQVGHFFRVTCKEEKALRNNKKFTTIDIQKNGVRFTNGKLSSLSEEYMRNREEYEEAQNAIVKEIISISAGYVDPIQTLNDVIAQLDAAVSFAYVSNSAPVPYVRPVILEKGQGKIM-LQSARHPCIEMQDDVAFIPNDITFEKEKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGSFVPCDSAEISIVDCILARVGAGDSQLKGVSTFMAEMLETASILRSATENSLIIIDELGRGTSTYDGFGLAWAISEYISTKIKAFCMFATHFHELTALADQVPTVNNLHVTALTTEDTLTMLYRIKRGVCDQSFGIHVAELANFPKHVIETAKEKALQLEEFQFVGNPDDCDDEPTRKRRCKEKEVC 878
BLAST of Msh2 vs. Ensembl Xenopus
Match: MSH2 (mutS homolog 2 [Source:NCBI gene;Acc:100380043]) HSP 1 Score: 639.802 bits (1649), Expect = 0.000e+0 Identity = 345/845 (40.83%), Postives = 536/845 (63.43%), Query Frame = 1
Query: 25 NSFSLFWNSLGDKPNSTIRFFDRQDYYTVHFEDAEMLARSYYKSMEILKYFRRDSVSSPYINISKSNSDGVFKYLLIANQYKVEVYSNNKSHDS-----WNLDFVATPGNLEKYQDILFKDVELVSSNSLLGLNIKRINDDYRIFLGFCDLDNGIFMIGGFEESFTGYEQLANLSSALFQLNCRECLIPN-DTRPELLAVKNAVQS-AGLLVTEVKKSFFSSENVMNSILKLICKTKLNNENTVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNILP-SPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFD-ESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAK---LKLSEYE 2523
N F F+ S+ +KP++T+R FDR DYYTVH DA A+ +K+ ++KY S + +SK N + V K LL+ QY+VEVY N S W L F A+PGNL ++++ILF + ++ ++ ++G IK ++ + + +G +D+ + +G E F +Q +NL + L Q+ +EC++P DT ++ ++ S G+L+T+ KK+ F++++ + + +L+ K K + T L + E + L SV+ YL+L +DES F F + F L YM++ ALN+ P S D SL GLLN C+T G+RL+ QWIKQPLMD N I RL++VE+ + D +LR CL E+ LRR PDL R+ ++ QR NLQD Y+LY A+ Q ++ + ++ G ++ ++ + ++ + ++ D F +M + D + V+NHEF VK D +L E M L+ M+ + + +LG+++ K +K ES++ +G++ RV+ K+E LRN + I+ K+GV+F + +++ ++E Y+++R +YEE + +I++EI+ I+ YV + L+ +IA+LD S A + AP Y RP +++ + ++ +++ RHP +EMQ+++++I NDI+F+ E + F IITGPNMGGKSTYIR G+I +MAQIGSFVPCD AEISI D I+ R+GAGD QL GVSTFMAEML+ + IL++AT SLIIIDELGRGTST+DGFGLAW+ISE+I+T++KAF FATHFHELT L+ VNNLHVTA T + L +Y+++ G +S+GI VA+ + P I+ AK L+L E++
Sbjct: 17 NGFISFYQSMPEKPDTTVRVFDRNDYYTVHGGDAIFAAKEVFKTNGVIKYLGSGSKKLESVVLSKMNFESVVKDLLLVRQYRVEVYKNKSGGKSSKENDWQLAFKASPGNLTQFEEILFGNSDMSTAVGVVG--IKLVSAEGQRLVGVGYVDSTLRKLGVCE--FPDNDQFSNLEALLVQIGPKECVMPGGDTAGDMGKLRQVRDSRGGILITDRKKAEFTTKDSVQDLNRLL-KAKKGEQVTSAALPEMEKQVAMSALASVMKYLELLSDESNFGQFVMTNFDLSQYMKLDNAAVGALNLFPGSAEDTSGTQSLAGLLNKCKTPQGQRLVNQWIKQPLMDKNRIEERLNLVEAFVTDAELRQCLQEDLLRRFPDLNRLAKKFQRQTANLQDCYRLYQAVNQLPGVIQAIEKYEGTHQMLLLAVFATPLSDLSSDFSKFQEMIETTLDMDQVENHEFLVKASFDPNLTELREKMNELEKNMQAALNGAARELGLDAGKSIKLESNSQVGHFFRVTCKEEKALRNNKKFTTIDIQKNGVRFTNGKLSSLSEEYMRNREEYEEAQNAIVKEIISISAGYVDPIQTLNDVIAQLDAAVSFAYVSNSAPVPYVRPVILEKGQGKIM-LQSARHPCIEMQDDVAFIPNDITFEKEKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGSFVPCDSAEISIVDCILARVGAGDSQLKGVSTFMAEMLETASILRSATENSLIIIDELGRGTSTYDGFGLAWAISEYISTKIKAFCMFATHFHELTALADQVPTVNNLHVTALTTEDTLTMLYRIKRGVCDQSFGIHVAELANFPKHVIETAKEKALQLEEFQ 855
BLAST of Msh2 vs. Ensembl Xenopus
Match: MSH2 (mutS homolog 2 [Source:NCBI gene;Acc:100380043]) HSP 1 Score: 638.647 bits (1646), Expect = 0.000e+0 Identity = 344/845 (40.71%), Postives = 536/845 (63.43%), Query Frame = 1
Query: 25 NSFSLFWNSLGDKPNSTIRFFDRQDYYTVHFEDAEMLARSYYKSMEILKYFRRDSVSSPYINISKSNSDGVFKYLLIANQYKVEVYSNNKSHDS-----WNLDFVATPGNLEKYQDILFKDVELVSSNSLLGLNIKRINDDYRIFLGFCDLDNGIFMIGGFEESFTGYEQLANLSSALFQLNCRECLIPN-DTRPELLAVKNAVQS-AGLLVTEVKKSFFSSENVMNSILKLICKTKLNNENTVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNILP-SPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFD-ESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAK---LKLSEYE 2523
N F F+ S+ +KP++T+R FDR DYYTVH DA A+ +K+ ++KY + + +SK N + V K LL+ QY+VEVY N S W L F A+PGNL ++++ILF + ++ ++ ++G IK ++ + + +G +D+ + +G E F +Q +NL + L Q+ +EC++P DT ++ ++ S G+L+T+ KK+ F++++ + + +L+ K K + T L + E + L SV+ YL+L +DES F F + F L YM++ ALN+ P S D SL GLLN C+T G+RL+ QWIKQPLMD N I RL++VE+ + D +LR CL E+ LRR PDL R+ ++ QR NLQD Y+LY A+ Q ++ + ++ G ++ ++ + ++ + ++ D F +M + D + V+NHEF VK D +L E M L+ M+ + + +LG+++ K +K ES++ +G++ RV+ K+E LRN + I+ K+GV+F + +++ ++E Y+++R +YEE + +I++EI+ I+ YV + L+ +IA+LD S A + AP Y RP +++ + ++ +++ RHP +EMQ+++++I NDI+F+ E + F IITGPNMGGKSTYIR G+I +MAQIGSFVPCD AEISI D I+ R+GAGD QL GVSTFMAEML+ + IL++AT SLIIIDELGRGTST+DGFGLAW+ISE+I+T++KAF FATHFHELT L+ VNNLHVTA T + L +Y+++ G +S+GI VA+ + P I+ AK L+L E++
Sbjct: 17 NGFISFYQSMPEKPDTTVRVFDRNDYYTVHGGDAIFAAKEVFKTNGVIKYLGSGASKLESVVLSKMNFESVVKDLLLVRQYRVEVYKNKSGGKSSKENDWQLAFKASPGNLTQFEEILFGNSDMSTAVGVVG--IKLVSAEGQRLVGVGYVDSTLRKLGVCE--FPDNDQFSNLEALLVQIGPKECVMPGGDTAGDMGKLRQVRDSRGGILITDRKKAEFTTKDSVQDLNRLL-KAKKGEQVTSAALPEMEKQVAMSALASVMKYLELLSDESNFGQFVMTNFDLSQYMKLDNAAVGALNLFPGSAEDTSGTQSLAGLLNKCKTPQGQRLVNQWIKQPLMDKNRIEERLNLVEAFVTDAELRQCLQEDLLRRFPDLNRLAKKFQRQTANLQDCYRLYQAVNQLPGVIQAIEKYEGTHQMLLLAVFATPLSDLSSDFSKFQEMIETTLDMDQVENHEFLVKASFDPNLTELREKMNELEKNMQAALNGAARELGLDAGKSIKLESNSQVGHFFRVTCKEEKALRNNKKFTTIDIQKNGVRFTNGKLSSLSEEYMRNREEYEEAQNAIVKEIISISAGYVDPIQTLNDVIAQLDAAVSFAYVSNSAPVPYVRPVILEKGQGKIM-LQSARHPCIEMQDDVAFIPNDITFEKEKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGSFVPCDSAEISIVDCILARVGAGDSQLKGVSTFMAEMLETASILRSATENSLIIIDELGRGTSTYDGFGLAWAISEYISTKIKAFCMFATHFHELTALADQVPTVNNLHVTALTTEDTLTMLYRIKRGVCDQSFGIHVAELANFPKHVIETAKEKALQLEEFQ 855
BLAST of Msh2 vs. Ensembl Xenopus
Match: MSH2 (mutS homolog 2 [Source:NCBI gene;Acc:100380043]) HSP 1 Score: 622.468 bits (1604), Expect = 0.000e+0 Identity = 339/846 (40.07%), Postives = 532/846 (62.88%), Query Frame = 1
Query: 25 NSFSLFWNSLGDKPNSTIRFFDRQDYYTVHFEDAEMLARSYYKSMEILKYFRRDSVSSPYINISKSNSDGVFKYLLIANQYKVEVYSNNKSHDS-----WNLDFVATPGNLEKYQDILFKDVELVSSNSLLGLNIKRINDDYRIFLGFCDLDNGIFMIGGFEESFTGYEQLANLSSALFQLNCRECLIPN-DTRPELLAVKNAVQSAGLLVTEVKKSFFSSENVMNSILKLICKTKLNNENTVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNILP---SPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFD-ESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAK---LKLSEYE 2523
N F F+ S+ +KP++T+R FDR DYYTVH DA A+ +K+ ++KY S + +SK N + V K LL+ QY+VEVY N S W L F A+PGNL ++++ILF + ++ ++ ++G IK ++ + + +G +D+ + +G E F +Q +NL + L Q+ +EC++P DT ++ ++ V+ G+L+T+ KK+ F++++ + + +L+ K K + T L + E + L SV+ YL+L +DES F F + F L YM++ ALN+ P +P SL GLLN C+T G+RL+ QWIKQPLMD N I RL++VE+ + D +LR CL E+ LRR PDL R+ ++ QR NLQD Y+LY A+ Q ++ + ++ G ++ ++ + ++ + ++ D F +M + D + V+NHEF VK D +L E M L+ M+ + + +LG+++ K +K ES++ +G++ RV+ K+E LRN + I+ K+GV+F + +++ ++E Y+++R +YEE + +I++EI+ I+ YV + L+ +IA+LD S A + AP Y RP +++ + ++ +++ RHP +EMQ+++++I NDI+F+ E + F IITGPNMGGKSTYIR G+I +MAQIGSFVPCD AEISI D I+ R+GAGD QL GVSTFMAEML+ + IL++AT SLIIIDELGRGTST+DGFGLAW+ISE+I+T++KAF FATHFHELT L+ VNNLHVT + ++ + + + S+GI VA+ + P I+ AK L+L E++
Sbjct: 7 NGFISFYQSMPEKPDTTVRVFDRNDYYTVHGGDAIFAAKEVFKTNGVIKYLGSGSKKLESVVLSKMNFESVVKDLLLVRQYRVEVYKNKSGGKSSKENDWQLAFKASPGNLTQFEEILFGNSDMSTAVGVVG--IKLVSAEGQRLVGVGYVDSTLRKLGVCE--FPDNDQFSNLEALLVQIGPKECVMPGGDTAGDMGKLRQIVKRGGILITDRKKAEFTTKDSVQDLNRLL-KAKKGEQVTSAALPEMEKQVAMSALASVMKYLELLSDESNFGQFVMTNFDLSQYMKLDNAAVGALNLFPVSVTPIIHSGTQSLAGLLNKCKTPQGQRLVNQWIKQPLMDKNRIEERLNLVEAFVTDAELRQCLQEDLLRRFPDLNRLAKKFQRQTANLQDCYRLYQAVNQLPGVIQAIEKYEGTHQMLLLAVFATPLSDLSSDFSKFQEMIETTLDMDQVENHEFLVKASFDPNLTELREKMNELEKNMQAALNGAARELGLDAGKSIKLESNSQVGHFFRVTCKEEKALRNNKKFTTIDIQKNGVRFTNGKLSSLSEEYMRNREEYEEAQNAIVKEIISISAGYVDPIQTLNDVIAQLDAAVSFAYVSNSAPVPYVRPVILEKGQGKIM-LQSARHPCIEMQDDVAFIPNDITFEKEKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGSFVPCDSAEISIVDCILARVGAGDSQLKGVSTFMAEMLETASILRSATENSLIIIDELGRGTSTYDGFGLAWAISEYISTKIKAFCMFATHFHELTALADQVPTVNNLHVTYILMASKTVCSFV---DAHLLSFGIHVAELANFPKHVIETAKEKALQLEEFQ 843
BLAST of Msh2 vs. Ensembl Xenopus
Match: MSH2 (mutS homolog 2 [Source:NCBI gene;Acc:100380043]) HSP 1 Score: 622.083 bits (1603), Expect = 0.000e+0 Identity = 344/845 (40.71%), Postives = 525/845 (62.13%), Query Frame = 1
Query: 25 NSFSLFWNSLGDKPNSTIRFFDRQDYYTVHFEDAEMLARSYYKSMEILKYFRRDSVSSPYINISKSNSDGVFKYLLIANQYKVEVYSNNKSHDS-----WNLDFVATPGNLEKYQDILFKDVELVSSNSLLGLNIKRINDDYRIFLGFCDLDNGIFMIGGFEESFTGYEQLANLSSALFQLNCRECLIPN-DTRPELLAVKNAVQSAGLLVTEVKKSFFSSENVMNSILKLICKTKLNNENTVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNILP-SPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSE-LSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFD-ESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAK---LKLSEYE 2523
N F F+ S+ +KP++T+R FDR DYYTVH DA A+ +K+ ++KY S + +SK N + V K LL+ QY+VEVY N S W L F A+PGNL ++++ILF + ++ ++ ++G IK ++ + + +G +D+ + +G E F +Q +NL + L Q+ +EC++P DT ++ ++ V+ G+L+T+ KK+ F++++ + + +L+ K K + T L + E + L SV+ YL+L +DES F F + F L YM++ ALN+ P S D SL GLLN C+T G+RL+ QWIKQPLMD N I RL++VE+ + D +LR CL E+ LRR PDL R+ ++ QR NLQD Y+LY A+ Q ++ + ++ Q + LS +Q V+NHEF VK D +L E M L+ M+ + + +LG+++ K +K ES++ +G++ RV+ K+E LRN + I+ K+GV+F + +++ ++E Y+++R +YEE + +I++EI+ I+ YV + L+ +IA+LD S A + AP Y RP +++ + ++ +++ RHP +EMQ+++++I NDI+F+ E + F IITGPNMGGKSTYIR G+I +MAQIGSFVPCD AEISI D I+ R+GAGD QL GVSTFMAEML+ + IL++AT SLIIIDELGRGTST+DGFGLAW+ISE+I+T++KAF FATHFHELT L+ VNNLHVTA T + L +Y+++ G +S+GI VA+ + P I+ AK L+L E++
Sbjct: 17 NGFISFYQSMPEKPDTTVRVFDRNDYYTVHGGDAIFAAKEVFKTNGVIKYLGSGSKKLESVVLSKMNFESVVKDLLLVRQYRVEVYKNKSGGKSSKENDWQLAFKASPGNLTQFEEILFGNSDMSTAVGVVG--IKLVSAEGQRLVGVGYVDSTLRKLGVCE--FPDNDQFSNLEALLVQIGPKECVMPGGDTAGDMGKLRQIVKRGGILITDRKKAEFTTKDSVQDLNRLL-KAKKGEQVTSAALPEMEKQVAMSALASVMKYLELLSDESNFGQFVMTNFDLSQYMKLDNAAVGALNLFPGSAEDTSGTQSLAGLLNKCKTPQGQRLVNQWIKQPLMDKNRIEERLNLVEAFVTDAELRQCLQEDLLRRFPDLNRLAKKFQRQTANLQDCYRLYQAVNQLPGVIQAIEKYEAASFSAWQDQRLSQPLQ--------------------LVENHEFLVKASFDPNLTELREKMNELEKNMQAALNGAARELGLDAGKSIKLESNSQVGHFFRVTCKEEKALRNNKKFTTIDIQKNGVRFTNGKLSSLSEEYMRNREEYEEAQNAIVKEIISISAGYVDPIQTLNDVIAQLDAAVSFAYVSNSAPVPYVRPVILEKGQGKIM-LQSARHPCIEMQDDVAFIPNDITFEKEKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGSFVPCDSAEISIVDCILARVGAGDSQLKGVSTFMAEMLETASILRSATENSLIIIDELGRGTSTYDGFGLAWAISEYISTKIKAFCMFATHFHELTALADQVPTVNNLHVTALTTEDTLTMLYRIKRGVCDQSFGIHVAELANFPKHVIETAKEKALQLEEFQ 835
BLAST of Msh2 vs. Ensembl Mouse
Match: Msh2 (mutS homolog 2 [Source:MGI Symbol;Acc:MGI:101816]) HSP 1 Score: 622.468 bits (1604), Expect = 0.000e+0 Identity = 340/846 (40.19%), Postives = 529/846 (62.53%), Query Frame = 1
Query: 28 SFSLFWNSLGDKPNSTIRFFDRQDYYTVHFEDAEMLARSYYKSMEILKYF-RRDSVSSPYINISKSNSDGVFKYLLIANQYKVEVYSN---NKS--HDSWNLDFVATPGNLEKYQDILFKDVELVSSNSLLGLNIKRINDDYRIFLGFCDLDNGIFMIGGFEESFTGYEQLANLSSALFQLNCRECLIPN-DTRPELLAVKNAVQSAGLLVTEVKKSFFSSENVMNSILKLICKTKLNNENTVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNILP-SPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFDESRT-FQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAK---LKLSEYENL 2529
F F+ + +KP++T+R FDR D+YT H EDA + AR +K+ ++KY S + + +SK N + K LL+ QY+VEVY N NK+ + W L F A+PGNL +++DILF + ++ +S ++G+ + ++ + +G+ D + F E+ +Q +NL + L Q+ +EC++P +T ++ ++ +Q G+L+TE K++ FS++++ + +L+ K K + L + E + L +VI +L+L +D+S F F++ TF YM++ RALN+ S D SL LLN C+TA G+RL+ QWIKQPLMD N I RL++VE+ + D++LR L E+ LRR PDL R+ ++ QR NLQD Y+LY + Q ++ L ++ G ++ ++ + + + ++ D F +M + D + V+NHEF VK D +L E M L+ +M++ + LG++ KQ+K +SS GYY RV+ K+E VLRN S ++ K+GVKF +++++ +NE Y +++ +YEE + +I++EI+ I++ YV + L+ ++A LD + S A + AP Y RP +++ K R+ +K RH VE+Q+ +++I ND+ F++ + F IITGPNMGGKSTYIR G+I +MAQIG FVPC+ AE+SI D I+ R+GAGD QL GVSTFMAEML+ + IL++AT SLIIIDELGRGTST+DGFGLAW+IS++IAT++ AF FATHFHELT L+ VNNLHVTA T L +Y+V++G +S+GI VA+ + P I AK L+L E++N+
Sbjct: 18 GFVRFFEGMPEKPSTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGSKTLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNKAGNKASKENEWYLAFKASPGNLSQFEDILFGNNDMSASVGVMGIKMAVVDGQRHVGVGYVDSTQRKLGLCEFPEN----DQFSNLEALLIQIGPKECVLPGGETTGDMGKLRQVIQRGGILITERKRADFSTKDIYQDLNRLL-KGKKGEQINSAALPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELATFDFSQYMKLDMAAVRALNLFQGSVEDTTGSQSLAALLNKCKTAQGQRLVNQWIKQPLMDRNRIEERLNLVEAFVEDSELRQSLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPSVIQALEKYEGRHQALLLAVFVTPLIDLRSDFSKFQEMIETTLDMDQVENHEFLVKPSFDPNLSELREVMDGLEKKMQSTLINAARGLGLDPGKQIKLDSSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTNSELSSLNEEYTKNKGEYEEAQDAIVKEIVNISSGYVEPMQTLNDVLAHLDAIVSFAHVSNAAPVPYVRPVILEKGKGRII-LKASRHACVEVQDEVAFIPNDVHFEKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDSQLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISDYIATKIGAFCMFATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFPRHVIACAKQKALELEEFQNI 857
BLAST of Msh2 vs. Ensembl Mouse
Match: Msh3 (mutS homolog 3 [Source:MGI Symbol;Acc:MGI:109519]) HSP 1 Score: 229.565 bits (584), Expect = 4.343e-62 Identity = 202/736 (27.45%), Postives = 349/736 (47.42%), Query Frame = 1
Query: 490 FEESFTGYEQLANLSSALFQLNCRECLIPND-TRPELLAVKNA----VQSAGLLVTEVKKSFFSSENVMNSILKLICKTKLNNENTVLKLVDTEGAET-----------IGCLGSVITYLDLANDESFFNFFDVQTFKLDN----YMRVGEQCSRALNILPSPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLL----NEHNGPYKCIIQSELSSVI----QEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQ-LKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMT------LMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSII---AKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVE--MQNNMSYIANDISFDESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHC-NVNNLHV--------------TAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYENLM 2532
F++S + E +SS L E L+P+D + P + ++ A V+ + V + ++F + ++ + + ++VD++G+++ I L +VI YL N E + ++FK + +MR+ R L IL + D++ SL +L+ +T+ G R L W+ QPL+ + IN RLD V +++ E LR++PD++R + K + Q+ + + +L Q L L N H +QS+L + E+L E+++++ N D E K+ + + K + E + S ++ ++ ++ LK S Y+ VS ++ + S +S I D VK ST+ + ESY + + E+ E + + H L + A +D + SLA + G Y RP + ++ K +KN RHP+++ + ++ N S +S IITGPNMGGKS+YI+ + L+++MAQIGS+VP + A I I D I TR+GA D G STFM E+ D + I++ A+ +SL+I+DELGRGTST DG +A++ E+ ++K+ + F TH+ + +L K + V N H+ + + + + F+Y++ G A RSYG+ VAK + +P E ++ A K E E L+
Sbjct: 363 FQDSASRLELETRISS----LQPVELLLPSDLSVPTEMLIQRATNVSVRDDRIRVERMNNTYFEYSHAFQTVTEFYAR----------EIVDSQGSQSLSGVINLEKPVICALAAVIRYLKEFNLEKMLS--KPESFKQLSSGMEFMRINGTTLRNLEILQNQTDMKTKGSLLWVLDHTKTSFGRRKLKNWVTQPLLKLREINARLDAVSDVLHSESSVFEQIENLLRKLPDVERGLCSIYHKKCSTQEFFLIVKSLCQLKSELQALMPAVNSH-------VQSDLLRALIVEAPELLSPVEHYLKVL----------NGPAAKVGDKTELFKDLSDFPLIKKRKNEIQEVIHSIQMRLQEFRKILKLPSLQ----YVTVSGQEFMIEIKNSAVSCIPA--DWVKVGSTKAVSRFHPPFIVESYRRLNQLREQLVLDCNAEWLGFLENFGEHYHTLCKAVDHLATVDCIFSLAKV--AKQGNYCRPTLQEEKK---IIIKNGRHPMIDVLLGEQDQFVPNSTSLSDSERVMIITGPNMGGKSSYIKQVALVTIMAQIGSYVPAEEATIGIVDGIFTRMGAADNIYKGRSTFMEELTDTAEIIRRASPQSLVILDELGRGTSTHDGIAIAYATLEYFIRDVKSLTLFVTHYPPVCELEKCYPEQVGNYHMGFLVNEDESKQDSGDMEQMPDSVTFLYQITRGIAARSYGLNVAKLADVPREVLQKAAHKSKELEGLV 1054
BLAST of Msh2 vs. Ensembl Mouse
Match: Msh3 (mutS homolog 3 [Source:MGI Symbol;Acc:MGI:109519]) HSP 1 Score: 225.328 bits (573), Expect = 1.156e-60 Identity = 202/737 (27.41%), Postives = 349/737 (47.35%), Query Frame = 1
Query: 490 FEESFTGYEQLANLSSALFQLNCRECLIPND-TRPELLAVKNA----VQSAGLLVTEVKKSFFSSENVMNSILKLICKTKLNNENTVLKLVDTEGAET-----------IGCLGSVITYLDLANDESFFNFFDVQTFKLDN----YMRVGEQCSRALNILPSPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLL----NEHNGPYKCIIQSELSSVI----QEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQ-LKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMT------LMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSII---AKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVE--MQNNMSYIANDISFDE-SRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHC-NVNNLHV--------------TAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYENLM 2532
F++S + E +SS L E L+P+D + P + ++ A V+ + V + ++F + ++ + + ++VD++G+++ I L +VI YL N E + ++FK + +MR+ R L IL + D++ SL +L+ +T+ G R L W+ QPL+ + IN RLD V +++ E LR++PD++R + K + Q+ + + +L Q L L N H +QS+L + E+L E+++++ N D E K+ + + K + E + S ++ ++ ++ LK S Y+ VS ++ + S +S I D VK ST+ + ESY + + E+ E + + H L + A +D + SLA + G Y RP + ++ K +KN RHP+++ + ++ N S + S IITGPNMGGKS+YI+ + L+++MAQIGS+VP + A I I D I TR+GA D G STFM E+ D + I++ A+ +SL+I+DELGRGTST DG +A++ E+ ++K+ + F TH+ + +L K + V N H+ + + + + F+Y++ G A RSYG+ VAK + +P E ++ A K E E L+
Sbjct: 363 FQDSASRLELETRISS----LQPVELLLPSDLSVPTEMLIQRATNVSVRDDRIRVERMNNTYFEYSHAFQTVTEFYAR----------EIVDSQGSQSLSGVINLEKPVICALAAVIRYLKEFNLEKMLS--KPESFKQLSSGMEFMRINGTTLRNLEILQNQTDMKTKGSLLWVLDHTKTSFGRRKLKNWVTQPLLKLREINARLDAVSDVLHSESSVFEQIENLLRKLPDVERGLCSIYHKKCSTQEFFLIVKSLCQLKSELQALMPAVNSH-------VQSDLLRALIVEAPELLSPVEHYLKVL----------NGPAAKVGDKTELFKDLSDFPLIKKRKNEIQEVIHSIQMRLQEFRKILKLPSLQ----YVTVSGQEFMIEIKNSAVSCIPA--DWVKVGSTKAVSRFHPPFIVESYRRLNQLREQLVLDCNAEWLGFLENFGEHYHTLCKAVDHLATVDCIFSLAKV--AKQGNYCRPTLQEEKK---IIIKNGRHPMIDVLLGEQDQFVPNSTSLSQDSERVMIITGPNMGGKSSYIKQVALVTIMAQIGSYVPAEEATIGIVDGIFTRMGAADNIYKGRSTFMEELTDTAEIIRRASPQSLVILDELGRGTSTHDGIAIAYATLEYFIRDVKSLTLFVTHYPPVCELEKCYPEQVGNYHMGFLVNEDESKQDSGDMEQMPDSVTFLYQITRGIAARSYGLNVAKLADVPREVLQKAAHKSKELEGLV 1055
BLAST of Msh2 vs. Ensembl Mouse
Match: Msh4 (mutS homolog 4 [Source:MGI Symbol;Acc:MGI:1860077]) HSP 1 Score: 209.149 bits (531), Expect = 2.480e-56 Identity = 166/568 (29.23%), Postives = 283/568 (49.82%), Query Frame = 1
Query: 874 VGEQCSRALNILPSPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRN-------------------KGNLQDIYKLYVALRQASDMLNLLNEHNGPYK----CIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNK---SFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFDESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGN------ELIFMYKVEEG-PAVRSYGIEVAKASGLP 2478
+ ++ L +L + D R + +L+G+LN +TA G R L I +PL+DV I+ RLD V+ L+ D +L L + + R D +++ L + K L+ + L V L+ S LL + G + +I ++ +VI + + + + M T + V+ ++ E L + + + +++++K + L+ S+S G++++++ + ++ FI I +K+ F S + MNE + R+ I+ +++ +++ L++LS ++ LD+L S A C Y RP+ D +K HP++E + +AN+ E IITGPNM GKSTY++ I L +MAQIGS+VP + A I +I TRI D T STFM EM +I++IL A KSLI+IDELGRGT+T +G G+++++ EH+ + +KAF+ F THF EL L ++ NV N+H Q + N +++ YK+ G ++YG++ A+AS LP
Sbjct: 140 IDSSSAQNLELLVNNQDYRSNHTLFGVLNYTKTAGGSRRLRSNILEPLVDVETISMRLDCVQELLQDEELFFGL-QSVISRFLDTEQLLSVLVQIPKQDTVNAAESKITNLIYLKHTLELVEPLKVTLKNCST--PLLRAYYGSLEDHRFGLILDKIKTVINDDARYMKGCLNMRT---------QKCYAVRSNISEFLDIARRTYTEIVDDIAGMIAQLAEKYSLP----LRTSFSSSRGFFIQMTTDCAALSSDQLPSEFIKI-SKVKNSYSFTSADLIKMNERCQESLREIYHMTYMIVCKLLSEIYEHIHCLYKLSDTVSMLDMLLSFA-HACTL-SDYVRPEFTD-----TLAIKQGWHPILEKISAEKPVANNTYITEGSNVLIITGPNMSGKSTYLKQIALCQIMAQIGSYVPAEYASFRIAAQIFTRISTDDDIETNSSTFMKEMKEIAYILHNANDKSLILIDELGRGTNTEEGIGISYAVCEHLLS-IKAFTLFTTHFLELCHLDALYLNVENMHFEVQHVKNTSRNKDAILYTYKLSRGLTEEKNYGLKAAEASSLP 682
BLAST of Msh2 vs. Ensembl Mouse
Match: Msh4 (mutS homolog 4 [Source:MGI Symbol;Acc:MGI:1860077]) HSP 1 Score: 207.994 bits (528), Expect = 2.007e-55 Identity = 169/560 (30.18%), Postives = 280/560 (50.00%), Query Frame = 1
Query: 898 LNILPSPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPD-------LQRITRRLQRN------------KGNLQDIYKLYVALRQASDMLNLLNEHNGPYK----CIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFIS---IIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFDESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGN------ELIFMYKVEEG-PAVRSYGIEVAKASGLP 2478
L +L + D R + +L+G+LN +TA G R L I +PL+DV I+ RLD V+ L+ D +L L + + R D L +I ++ N K L+ + L V L+ S LL + G + +I ++ +VI + + + + M T + V+ ++ E L + + + +++++K + L+ S+S G++++++ D L + S I +K+ F S + MNE + R+ I+ +++ +++ L++LS ++ LD+L S A C Y RP+ D +K HP++E + +AN+ E IITGPNM GKSTY++ I L +MAQIGS+VP + A I +I TRI D T STFM EM +I++IL A KSLI+IDELGRGT+T +G G+++++ EH+ + +KAF+ F THF EL L ++ NV N+H Q + N +++ YK+ G ++YG++ A+AS LP
Sbjct: 254 LELLVNNQDYRSNHTLFGVLNYTKTAGGSRRLRSNILEPLVDVETISMRLDCVQELLQDEELFFGL-QSVISRFLDTEQLLSVLVQIPKQDTVNAAESKITNLIYLKHTLELVEPLKVTLKNCST--PLLRAYYGSLEDHRFGLILDKIKTVINDDARYMKGCLNMRT---------QKCYAVRSNISEFLDIARRTYTEIVDDIAGMIAQLAEKYSLP----LRTSFSSSRGFFIQMT-TDCAALSSDQLPSEFIKISKVKNSYSFTSADLIKMNERCQESLREIYHMTYMIVCKLLSEIYEHIHCLYKLSDTVSMLDMLLSFA-HACTL-SDYVRPEFTD-----TLAIKQGWHPILEKISAEKPVANNTYITEGSNVLIITGPNMSGKSTYLKQIALCQIMAQIGSYVPAEYASFRIAAQIFTRISTDDDIETNSSTFMKEMKEIAYILHNANDKSLILIDELGRGTNTEEGIGISYAVCEHLLS-IKAFTLFTTHFLELCHLDALYLNVENMHFEVQHVKNTSRNKDAILYTYKLSRGLTEEKNYGLKAAEASSLP 788
BLAST of Msh2 vs. UniProt/SwissProt
Match: sp|Q5XXB5|MSH2_CHLAE (DNA mismatch repair protein Msh2 OS=Chlorocebus aethiops OX=9534 GN=MSH2 PE=2 SV=1) HSP 1 Score: 627.476 bits (1617), Expect = 0.000e+0 Identity = 341/841 (40.55%), Postives = 527/841 (62.66%), Query Frame = 1
Query: 28 SFSLFWNSLGDKPNSTIRFFDRQDYYTVHFEDAEMLARSYYKSMEILKYFRRDSVSS-PYINISKSNSDGVFKYLLIANQYKVEVYSN---NKS--HDSWNLDFVATPGNLEKYQDILFKDVELVSSNSLLGLNIKRINDDYRIFLGFCDLDNGIFMIGGFEESFTGYEQLANLSSALFQLNCRECLIPN-DTRPELLAVKNAVQSAGLLVTEVKKSFFSSENVMNSILKLICKTKLNNENTVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNILP-SPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFDESRT-FQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYE 2523
F F+ S+ +KP +T+R FDR D+YT H EDA + AR +K+ ++KY + + +SK N + K LL+ QY+VEVY N NK+ + W L + A+PGNL +++DILF + ++ +S ++G+ + ++ ++ +G+ D + F ++ +Q +NL + L Q+ +EC++P +T ++ ++ +Q G+L+TE KK+ FS++++ + +L+ K N+ + L + E + L +VI +L+L +D+S F F++ TF YM++ RALN+ S D SL LLN C+T G+RL+ QWIKQPLMD N I RL++VE+ + D +LR L E+ LRR PDL R+ ++ QR NLQD Y+LY + Q +++ L +H G ++ ++ + + + ++ D F +M + D + V+NHEF VK D +L E M L+ +M++ + LG++ KQ+K +SS GYY RV+ K+E VLRN S ++ K+GVKF ++++T +NE Y +++ +YEE + +I++EI+ I++ YV + L+ ++A+LD + S A + GAP Y RP +++ + R+ +K RH VE+Q+ +++I NDI F++ + F IITGPNMGGKSTYIR G+I +MAQIG FVPC+ AE+SI D I+ R+GAGD QL GVSTFMAEML+ + IL++AT SLIIIDELGRGTST+DGFGLAW+ISE+IAT++ AF FATHFHELT L+ VNNLHVTA T L +Y+V++G +S+GI VA+ + P I+ AK K E E
Sbjct: 18 GFVRFFQSMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSTVDGQRQVGVGYVDSTQRKLGLCEFPDN----DQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQDLNRLLKGKKGEQMNSAV-LPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELTTFDFSQYMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERLNLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKFQEMIETTLDMDQVENHEFLVKPSFDPNLSELREIMNDLEKKMQSTLISAARDLGLDPGKQIKLDSSTQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTNSKLTSLNEEYTKNKTEYEEAQDAIVKEIVNISSGYVEPMQTLNDVLAQLDAVVSFAHVSNGAPVPYVRPAILEKGQGRII-LKASRHACVEVQDEITFIPNDIYFEKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDSQLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAFCMFATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFPKHVIECAKQKALELE 852
BLAST of Msh2 vs. UniProt/SwissProt
Match: sp|P43246|MSH2_HUMAN (DNA mismatch repair protein Msh2 OS=Homo sapiens OX=9606 GN=MSH2 PE=1 SV=1) HSP 1 Score: 624.394 bits (1609), Expect = 0.000e+0 Identity = 342/841 (40.67%), Postives = 526/841 (62.54%), Query Frame = 1
Query: 28 SFSLFWNSLGDKPNSTIRFFDRQDYYTVHFEDAEMLARSYYKSMEILKYFRRDSVSS-PYINISKSNSDGVFKYLLIANQYKVEVYSN---NKS--HDSWNLDFVATPGNLEKYQDILFKDVELVSSNSLLGLNIKRINDDYRIFLGFCDLDNGIFMIGGFEESFTGYEQLANLSSALFQLNCRECLIPN-DTRPELLAVKNAVQSAGLLVTEVKKSFFSSENVMNSILKLICKTKLNNENTVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNILP-SPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFDESRT-FQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYE 2523
F F+ + +KP +T+R FDR D+YT H EDA + AR +K+ ++KY + + +SK N + K LL+ QY+VEVY N NK+ + W L + A+PGNL +++DILF + ++ +S ++G+ + ++ ++ +G+ D I G E F +Q +NL + L Q+ +EC++P +T ++ ++ +Q G+L+TE KK+ FS++++ + +L+ K N+ + L + E + L +VI +L+L +D+S F F++ TF YM++ RALN+ S D SL LLN C+T G+RL+ QWIKQPLMD N I RL++VE+ + D +LR L E+ LRR PDL R+ ++ QR NLQD Y+LY + Q +++ L +H G ++ ++ + + + ++ D F +M + D + V+NHEF VK D +L E M L+ +M++ + LG++ KQ+K +SS GYY RV+ K+E VLRN S ++ K+GVKF ++++T +NE Y +++ +YEE + +I++EI+ I++ YV + L+ ++A+LD + S A + GAP Y RP +++ + R+ +K RH VE+Q+ +++I ND+ F++ + F IITGPNMGGKSTYIR G+I +MAQIG FVPC+ AE+SI D I+ R+GAGD QL GVSTFMAEML+ + IL++AT SLIIIDELGRGTST+DGFGLAW+ISE+IAT++ AF FATHFHELT L+ VNNLHVTA T L +Y+V++G +S+GI VA+ + P I+ AK K E E
Sbjct: 18 GFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVD---SIQRKLGLCE-FPDNDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQDLNRLLKGKKGEQMNSAV-LPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELTTFDFSQYMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERLNLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKFQEMIETTLDMDQVENHEFLVKPSFDPNLSELREIMNDLEKKMQSTLISAARDLGLDPGKQIKLDSSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTNSKLTSLNEEYTKNKTEYEEAQDAIVKEIVNISSGYVEPMQTLNDVLAQLDAVVSFAHVSNGAPVPYVRPAILEKGQGRII-LKASRHACVEVQDEIAFIPNDVYFEKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDSQLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAFCMFATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFPKHVIECAKQKALELE 852
BLAST of Msh2 vs. UniProt/SwissProt
Match: sp|P43247|MSH2_MOUSE (DNA mismatch repair protein Msh2 OS=Mus musculus OX=10090 GN=Msh2 PE=1 SV=1) HSP 1 Score: 622.468 bits (1604), Expect = 0.000e+0 Identity = 340/846 (40.19%), Postives = 529/846 (62.53%), Query Frame = 1
Query: 28 SFSLFWNSLGDKPNSTIRFFDRQDYYTVHFEDAEMLARSYYKSMEILKYF-RRDSVSSPYINISKSNSDGVFKYLLIANQYKVEVYSN---NKS--HDSWNLDFVATPGNLEKYQDILFKDVELVSSNSLLGLNIKRINDDYRIFLGFCDLDNGIFMIGGFEESFTGYEQLANLSSALFQLNCRECLIPN-DTRPELLAVKNAVQSAGLLVTEVKKSFFSSENVMNSILKLICKTKLNNENTVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNILP-SPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFDESRT-FQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAK---LKLSEYENL 2529
F F+ + +KP++T+R FDR D+YT H EDA + AR +K+ ++KY S + + +SK N + K LL+ QY+VEVY N NK+ + W L F A+PGNL +++DILF + ++ +S ++G+ + ++ + +G+ D + F E+ +Q +NL + L Q+ +EC++P +T ++ ++ +Q G+L+TE K++ FS++++ + +L+ K K + L + E + L +VI +L+L +D+S F F++ TF YM++ RALN+ S D SL LLN C+TA G+RL+ QWIKQPLMD N I RL++VE+ + D++LR L E+ LRR PDL R+ ++ QR NLQD Y+LY + Q ++ L ++ G ++ ++ + + + ++ D F +M + D + V+NHEF VK D +L E M L+ +M++ + LG++ KQ+K +SS GYY RV+ K+E VLRN S ++ K+GVKF +++++ +NE Y +++ +YEE + +I++EI+ I++ YV + L+ ++A LD + S A + AP Y RP +++ K R+ +K RH VE+Q+ +++I ND+ F++ + F IITGPNMGGKSTYIR G+I +MAQIG FVPC+ AE+SI D I+ R+GAGD QL GVSTFMAEML+ + IL++AT SLIIIDELGRGTST+DGFGLAW+IS++IAT++ AF FATHFHELT L+ VNNLHVTA T L +Y+V++G +S+GI VA+ + P I AK L+L E++N+
Sbjct: 18 GFVRFFEGMPEKPSTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGSKTLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNKAGNKASKENEWYLAFKASPGNLSQFEDILFGNNDMSASVGVMGIKMAVVDGQRHVGVGYVDSTQRKLGLCEFPEN----DQFSNLEALLIQIGPKECVLPGGETTGDMGKLRQVIQRGGILITERKRADFSTKDIYQDLNRLL-KGKKGEQINSAALPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELATFDFSQYMKLDMAAVRALNLFQGSVEDTTGSQSLAALLNKCKTAQGQRLVNQWIKQPLMDRNRIEERLNLVEAFVEDSELRQSLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPSVIQALEKYEGRHQALLLAVFVTPLIDLRSDFSKFQEMIETTLDMDQVENHEFLVKPSFDPNLSELREVMDGLEKKMQSTLINAARGLGLDPGKQIKLDSSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTNSELSSLNEEYTKNKGEYEEAQDAIVKEIVNISSGYVEPMQTLNDVLAHLDAIVSFAHVSNAAPVPYVRPVILEKGKGRII-LKASRHACVEVQDEVAFIPNDVHFEKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDSQLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISDYIATKIGAFCMFATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFPRHVIACAKQKALELEEFQNI 857
BLAST of Msh2 vs. UniProt/SwissProt
Match: sp|Q3MHE4|MSH2_BOVIN (DNA mismatch repair protein Msh2 OS=Bos taurus OX=9913 GN=MSH2 PE=2 SV=1) HSP 1 Score: 620.157 bits (1598), Expect = 0.000e+0 Identity = 340/861 (39.49%), Postives = 534/861 (62.02%), Query Frame = 1
Query: 28 SFSLFWNSLGDKPNSTIRFFDRQDYYTVHFEDAEMLARSYYKSMEILKYFRRDSVSS-PYINISKSNSDGVFKYLLIANQYKVEVYSN---NKS--HDSWNLDFVATPGNLEKYQDILFKDVELVSSNSLLGLNIKRINDDYRIFLGFCDLDNGIFMIGGFEESFTGYEQLANLSSALFQLNCRECLIPN-DTRPELLAVKNAVQSAGLLVTEVKKSFFSSENVMNSILKLICKTKLNNENTVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNILP-SPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFDESRT-FQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAK---LKLSEYENLMEWDSNHSEKLAATR 2574
F F+ + +KP +T+R FDR D+YT H EDA + AR +K+ ++KY + + +SK N + K LL+ QY+VEVY N NK+ + W L F A+PGNL +++DILF + ++ +S ++G+ + ++ ++ +G+ D + F ++ +Q +NL + L Q+ +EC++P +T ++ ++ +Q G+L+TE K++ FS++++ + +L+ K N+ + L + E + L +VI +L+L +D+S F F++ TF YM++ RALN+ S D SL LLN C+T G+RL+ QWIKQPLMD N I RL++VE+ + D +LR L E+ LRR PDL R+ ++ QR NLQD Y+LY + Q +++ L ++ G ++ + + + + ++ D F +M + D + V+NHEF VK D +L E M L+ +M++ + LG++ KQ+K +SS GYY RV+ K+E VLRN S ++ K+GVKF ++++T +NE Y +++ +YEE + +I++EI+ I++ YV + L+ ++A+LD + S A + AP Y RP +++ + R+ +K RH VE+Q+ +++I ND+ F++ + F IITGPNMGGKSTYIR G++ +MAQIG FVPC+ AE+SI D I+ R+GAGD QL GVSTFMAEML+ + IL++AT SLIIIDELGRGTST+DGFGLAW+ISE+IAT++ AF FATHFHELT L+ VNNLHVTA T L +Y+V++G +S+GI VA+ + P I+ AK L+L E++N+ + + AA R
Sbjct: 18 GFVRFFQGMPEKPTTTVRLFDRGDFYTAHREDALLAAREVFKTQGVVKYMGPAGAKTLESVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKASKENDWYLAFKASPGNLSQFEDILFGNNDMSASIGVVGVKMSTVDGQRQVGVGYVDSTQRKLGLCEFPDN----DQFSNLEALLIQIGPKECVMPGGETAGDMGKLRQVIQRGGILITERKRADFSTKDIYQDLNRLLKGKKGEQVNSAV-LPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELTTFDFSQYMKLDIAAVRALNLFQGSVEDTSGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERLNLVEAFVEDAELRQNLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQALEKYEGKHQALFLAVFVTPLIDLRSDFSKFQEMIETTLDMDQVENHEFLVKPSFDPNLSELREIMDDLEKKMQSTLVSAARDLGLDPGKQIKLDSSTQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTNSKLTSLNEEYTKNKTEYEEAQNAIVKEIVNISSGYVEPMQTLNDVLAQLDAVVSFAHVSDAAPVPYVRPVILEKGRGRI-TLKASRHACVEVQDEVAFIPNDVHFEKDKQMFHIITGPNMGGKSTYIRQTGVVVLMAQIGCFVPCEWAEVSIVDCILARVGAGDSQLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAFCMFATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFPRHVIECAKQKALELEEFQNIGKPQECDEMEPAAKR 872
BLAST of Msh2 vs. UniProt/SwissProt
Match: sp|P54275|MSH2_RAT (DNA mismatch repair protein Msh2 OS=Rattus norvegicus OX=10116 GN=Msh2 PE=2 SV=1) HSP 1 Score: 618.616 bits (1594), Expect = 0.000e+0 Identity = 340/864 (39.35%), Postives = 535/864 (61.92%), Query Frame = 1
Query: 28 SFSLFWNSLGDKPNSTIRFFDRQDYYTVHFEDAEMLARSYYKSMEILKYFRRDSVSS-PYINISKSNSDGVFKYLLIANQYKVEVYSN---NKS--HDSWNLDFVATPGNLEKYQDILFKDVELVSSNSLLGLNIKRINDDYRIFLGFCDLDNGIFMIGGFEESFTGYEQLANLSSALFQLNCRECLIPN-DTRPELLAVKNAVQSAGLLVTEVKKSFFSSENVMNSILKLICKTKLNNENTVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNILP-SPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFDESRT-FQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAK---LKLSEYENLMEWDSNHSEKLAATRNAL 2583
F F+ + +KP++T+ FDR D+YT H EDA + AR +K+ ++KY + + +SK N + K LL+ Y+VEVY N NK+ + W L + A+PGNL +++DILF + ++ +S ++G+ + ++ ++ +G D+D+ +G E F +Q +NL + L Q+ +EC++P +T ++ ++ +Q G+L+TE K+ FS++++ + +L+ K N+ + L + E + L +VI +L+L +D+S F F++ TF YM++ RALN+ S D SL LN C+TA G+RL+ QWIKQPLMD N I RL++VE+ + D++LR L E+ LRR PDL R+ ++ QR NLQD Y+LY ++Q +++ L ++ G ++ ++ + + + ++ D F + + D + V+NHEF VK D +L E M L+ +M++ + LG++ KQ+K +SS GYY RV+ K+E VLRN S ++ K+GVKF +++++ +NE Y +++ +YEE + +I++EI+ I++ YV + ++ ++A LD + S A + AP Y RP +++ K R+ VK RH VE+Q+++++I ND+ F++ + F IITGPNMGGKSTYIR G+I +MAQIG FVPC+ AE+SI D I+ R+GAGD QL GVSTFMAEML+ + IL++AT SLIIIDELGRGTST+DGFGLAW+ISE+IAT + AF FATHFHELT L+ VNNLHVTA T L +Y+V+ G +S+GI VA+ + P I+ AK L+L E++++ + + AA R L
Sbjct: 18 GFVRFFEGMPEKPSTTVGLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKTLQTVVLSKMNFESFVKDLLLVRHYRVEVYKNKAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMATSIGIMGIKLSTVDGQRQVGVG--DVDSTQRKLGLCE--FPDNDQFSNLEALLIQIGPKECILPGGETAGDMGKLRQVIQRGGILITERKRIDFSTKDIYQDLNRLLKGRKGEQMNSAV-LPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELATFDFSQYMKLDMAAVRALNLFQGSVEDTTGSQSLAAFLNKCKTAQGQRLVSQWIKQPLMDKNRIEERLNLVEAFVEDSELRRALQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGVKQLPNVIQALEKYQGRHQALLLAVFVTPLTDLRSDFSKFQEKIETTLDMDQVENHEFLVKPSFDPNLSELREVMDGLEKKMQSTLISAARGLGLDPGKQIKLDSSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTNSELSSLNEEYTKNKGEYEEAQDAIVKEIVNISSGYVEPMQTVNDVLAHLDAVVSFAHVSNAAPVPYVRPVILEKGKGRII-VKASRHACVEVQHDVAFIPNDVHFEKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDSQLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATNIGAFCMFATHFHELTALASQIPTVNNLHVTALTTEETLTMLYQVKTGVCDQSFGIHVAELANFPRHVIECAKQKALELEEFQSIGTSQGHDETQPAAKRRCL 875
BLAST of Msh2 vs. TrEMBL
Match: G1BGJ9 (Msh2 (Fragment) OS=Schmidtea mediterranea OX=79327 GN=msh2 PE=2 SV=1) HSP 1 Score: 1788.47 bits (4631), Expect = 0.000e+0 Identity = 883/884 (99.89%), Postives = 884/884 (100.00%), Query Frame = 1
Query: 10 MDELTNSFSLFWNSLGDKPNSTIRFFDRQDYYTVHFEDAEMLARSYYKSMEILKYFRRDSVSSPYINISKSNSDGVFKYLLIANQYKVEVYSNNKSHDSWNLDFVATPGNLEKYQDILFKDVELVSSNSLLGLNIKRINDDYRIFLGFCDLDNGIFMIGGFEESFTGYEQLANLSSALFQLNCRECLIPNDTRPELLAVKNAVQSAGLLVTEVKKSFFSSENVMNSILKLICKTKLNNENTVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNILPSPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFDESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYENLMEWDSNHSEKLAATRNALMEFCLKDLVKDSIDFPVFVKMLRDKL 2661
MDELTNSFSLFWNSLGDKPNSTIRFFDRQDYYTVHFEDAEMLARSYYKSMEILKYFRRDSVSSPYINISKSNSDGVFKYLLIANQYKVEVYSNNKSHDSW+LDFVATPGNLEKYQDILFKDVELVSSNSLLGLNIKRINDDYRIFLGFCDLDNGIFMIGGFEESFTGYEQLANLSSALFQLNCRECLIPNDTRPELLAVKNAVQSAGLLVTEVKKSFFSSENVMNSILKLICKTKLNNENTVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNILPSPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHRRDYEEYERSIIEEIMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFDESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYENLMEWDSNHSEKLAATRNALMEFCLKDLVKDSIDFPVFVKMLRDKL
Sbjct: 1 MDELTNSFSLFWNSLGDKPNSTIRFFDRQDYYTVHFEDAEMLARSYYKSMEILKYFRRDSVSSPYINISKSNSDGVFKYLLIANQYKVEVYSNNKSHDSWDLDFVATPGNLEKYQDILFKDVELVSSNSLLGLNIKRINDDYRIFLGFCDLDNGIFMIGGFEESFTGYEQLANLSSALFQLNCRECLIPNDTRPELLAVKNAVQSAGLLVTEVKKSFFSSENVMNSILKLICKTKLNNENTVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNILPSPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHRRDYEEYERSIIEEIMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFDESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYENLMEWDSNHSEKLAATRNALMEFCLKDLVKDSIDFPVFVKMLRDKL 884
BLAST of Msh2 vs. TrEMBL
Match: A0A0L8HX88 (DNA_MISMATCH_REPAIR_2 domain-containing protein OS=Octopus bimaculoides OX=37653 GN=OCBIM_22003442mg PE=3 SV=1) HSP 1 Score: 663.3 bits (1710), Expect = 0.000e+0 Identity = 346/839 (41.24%), Postives = 541/839 (64.48%), Query Frame = 1
Query: 31 FSLFWNSLGDKPNSTIRFFDRQDYYTVHFEDAEMLARSYYKSMEILKYFRRDSVSSPYINISKSNSDGVFKYLLIANQYKVEVYSNNKSHDSWNLDFVATPGNLEKYQDILFKDVELVSSNSLLGLNIKRINDDYRIFLGFCDLDNGIFMIGGFEESFTGYEQLANLSSALFQLNCRECLIPNDTRPELLAVKNAVQSAGLLVTEVKKSFFSSENVMNSILKLICKTKLNNENTVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNILPSPNDL-RKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFDES-RTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYENLMEWD 2541
F F+ L +K ++T+R FDR DYYTVH DA +A+ +K++ ++KY S + +SK N + + + LL+ Y+VE+Y +KS + W+LDF A+PGNL +++DILF + E+ + +L + I ++ + DL + + FT +Q +NL + + QL +EC++ + +K + +GLL+TE KK F S++++ + +L+ K + +N+ L + + + L S++ YL+L +DE +F F + TF L Y+++ +ALNI P+P + K+ S++GLLN CRTA G+RLL QWIKQPL+D+N I RLD+VE+ IN+ +LR L+E+ L++IPD QR++++ R K NLQD Y++Y +L + ++ L + +GP+K ++ S+ I+E+L D F +M S D E V+NHEF +K + D+ L + +++ ++++ ++V+ LG+E K LK ES++ LGY+ RV+RK+E ++RN I+T K+GV+FH+T + +NE +++ R+DY E +++++ I+ I YV + Q++ I+A+LDV+ A + AP Y RPK+++ + + ++K RHP +EMQ+++S+I NDI F++ R F IITGPNMGGKSTYIRS+G I ++AQ+G FVPC+ AEISI D I+ R+GAGD QL GVSTFMAEML+ + IL++A+ SLIIIDELGRGTST+DGFGLAW+I+E+IAT++KAF FATHFHELT L+ V N HVTA T + L +YKV+ G +S+GI VA+ + P I+ AK K E E+ D
Sbjct: 19 FISFFRKLPEKSSATLRIFDRTDYYTVHGSDALFVAKEVFKTLGVVKYLGSGSNKMESVVLSKLNFESLVRDLLLVKAYRVELY-RSKSKNEWSLDFKASPGNLVQFEDILFTNCEMSCATGVLAVKIGTVSGQQMVGTALVDLTSHKMEVC----EFTDNDQFSNLEALIVQLGPKECVVCTSEINDSAWLKQVITRSGLLITEKKKGDFQSKDIVQDLNRLLKFQKEDQQNSA-ALPELDNTLAMAALSSLVKYLELLSDEGYFGQFKLSTFDLKQYLKLDAAAVKALNIQPNPYEGGNKNQSIFGLLNKCRTAPGQRLLSQWIKQPLVDINKIEERLDMVEAFINNTELRQSLHEDQLKKIPDYQRLSKKFYRKKANLQDCYRVYHSLSKLPYLVETLEKDDGPHKNLVMQVFSNPIKELLMDFTKFEEMIESTLDMEQVENHEFLIKPEFDDVLTSLREKLDEVEADIKSQLNKVARDLGVEPQKTLKLESNSQLGYFFRVTRKEEKLIRNNKTYLTIDTNKNGVRFHNTGLRQLNEEFVKLRQDYAEQQKTVVAGIIDIAAGYVEPMIQMNDILAQLDVMVCFAHVSANAPIPYVRPKLLEKG-SGIIRLKEARHPCLEMQDDVSFIPNDIEFEKKKRMFHIITGPNMGGKSTYIRSVGCIVLLAQLGCFVPCNEAEISIVDSILARVGAGDSQLKGVSTFMAEMLETASILRSASENSLIIIDELGRGTSTYDGFGLAWAIAEYIATKIKAFCLFATHFHELTLLADEVSTVINSHVTALTCNDTLTLLYKVKHGVCDQSFGIHVAELAHFPKHVIEFAKNKAKELEDFQSVD 850
BLAST of Msh2 vs. TrEMBL
Match: V3ZN41 (DNA_MISMATCH_REPAIR_2 domain-containing protein OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_195636 PE=3 SV=1) HSP 1 Score: 661.759 bits (1706), Expect = 0.000e+0 Identity = 354/838 (42.24%), Postives = 534/838 (63.72%), Query Frame = 1
Query: 31 FSLFWNSLGDKPNSTIRFFDRQDYYTVHFEDAEMLARSYYKSMEILKYFRRDSVSSPYINISKSNSDGVFKYLLIANQYKVEVYSNNKS--HDSWNLDFVATPGNLEKYQDILFKDVELVSSNSLLGLNIKRINDDYRIFLGFCDLDNGIFMIGGFEESFTGYEQLANLSSALFQLNCRECLI-PNDTRPELLAVKNAVQSAGLLVTEVKKSFFSSENVMNSILKLICKTKLNNENTVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNILPSPNDL-RKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFDES-RTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYENL 2529
F F L +KP++T+R FDR DYYTVH +DA +A+ +K+ ++KY + + +SK N + + + LL+ QY+VEVY N S ++ W L A+PGNL +++DILF + E+ S ++G+ + N + +G+ D F + FT +Q +NL + L QL +EC+I + E K + + +L+TE KKS F+ ++V+ + +L+ K K N+ L + + + L +VI YL+L +DES F + + TF L YMR+ RALNILP+PN+ K+ S+ GLLN CRTA G+RL+ QW+KQPLMD N I RL++VE+++ + +LR L EE LRRIPD Q++ ++ QR K LQD Y++Y A+ + +L +L +H+G ++ ++ S+ ++E+L D F +M + D V+NHE+ +K D DE+L + L+S ++++ ++V+ L +E+ K LK ES+N LGY+ RV+RKDE LRN I+T K+GV+F ++ ++ NE YL+++ +Y E ++S++ EI++I YV + ++ ++A+LDVL S + + AP + K+K RHP +EMQ+++S+I ND F+++ + F IITGPNMGGKSTYIRS+G++ +MAQ+G FVPC A+I+I D I+ R+GAGD QL GVSTFMAEML+ + IL++AT KSLIIIDELGRGTST+DGFGLAW+ISEHIAT++K F FATHFHELT LS + +VNNLHVTA T N L +Y+V+ G +S+GI VA+ + P I+ AK K E E+
Sbjct: 19 FLAFHRDLPEKPSTTLRVFDRTDYYTVHGQDAIFVAKEVFKTTGVVKYLGGGTKKLESVVLSKMNFESLMRDLLLVQQYRVEVYRNKGSSKNNDWILALKASPGNLSQFEDILFTNNEMAGSIGVIGIKVSTDNGQKIVGIGYADATVRKFSVC----EFTDNDQFSNLEALLVQLGPKECVIGTGELNTESGKFKQVLDRSNILITERKKSEFNCKDVIQDMNRLLKKKKGEQSNSA-TLSEMDRVHAVSALSAVIKYLELLSDESNFGQYQLTTFDLKQYMRLDSAAVRALNILPNPNEGGNKNQSVLGLLNKCRTAQGQRLIAQWVKQPLMDKNKIEERLNVVEAMLENTELRQTLQEEQLRRIPDFQKLAKKFQRKKATLQDCYRVYQAIDKMPYLLEILEKHDGNHRTLLMELFSNPLKELLMDFAKFQEMVETTMDLNQVENHEYVIKSDFDENLAALREKIDALESDIKSQINKVARDLNLEANKTLKLESNNQLGYFFRVTRKDEKALRNNKNYRTIDTNKNGVRFRNSAVSKYNEDYLKYKEEYNEQQKSVVSEIIEIAAGYVEPMLIINDVVAQLDVLASFSHVSSSAP------------IHGILKLKEARHPCLEMQDDVSFIPNDAMFEKAEKMFHIITGPNMGGKSTYIRSVGVVVLMAQLGCFVPCSSADITIVDSILARVGAGDSQLKGVSTFMAEMLETASILRSATEKSLIIIDELGRGTSTYDGFGLAWAISEHIATKIKPFCLFATHFHELTALSDVVSSVNNLHVTALTTNNTLTLLYRVKPGVCDQSFGIHVAELAHFPKHVIEFAKEKARELEDF 839
BLAST of Msh2 vs. TrEMBL
Match: T1IP55 (DNA_MISMATCH_REPAIR_2 domain-containing protein OS=Strigamia maritima OX=126957 PE=3 SV=1) HSP 1 Score: 652.129 bits (1681), Expect = 0.000e+0 Identity = 345/851 (40.54%), Postives = 541/851 (63.57%), Query Frame = 1
Query: 25 NSFSLFWNSLGDKPNSTIRFFDRQDYYTVHFEDAEMLARSYYKSMEILKYFRRDSVSSPYINISKSNSDGVFKYLLIANQYKVEVYSN---NKSHDSWNLDFVATPGNLEKYQDILFKDVELVSSNSLLGLNIKRINDDYRIFLGFCDLDNGIFMIGGFEESFTGYEQLANLSSALFQLNCRECLIPNDTRPELLAVKNAVQSAGLLVTEVKKSFFSSENVMNSILKLICKTKLNNENTVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNILPSPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFDESRT-FQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYENLMEWDSNHSEKLA 2565
++F F+ SL DKP STIR FDR D+YTVH DA ++ ++K+ ++KY ++ + +SK N + + + LL+ Y+VEVY N NKS+D W L+F A+PGNL +++DILF + ++ + ++ +IK IND+ +G LDN + I E FT ++ +NL + + QL +ECL+P++ + VK G+LVTE KKS F+ ++++ + +L+ K + EN+ L + I L ++I YL+L ++ FN + + F L ++R+ +ALN+LP P + K S++GLLN CRTA G+RLL +W+ QPL D+NLI RLD+VE I+D+ + + ++L+R PD QRI ++ ++ K NLQD++++Y A+ + ++++++L +++G + ++ + E+ K F ++ S D E N E+ V + DE L E + L+ ++E + + L ++ K +K E++N +G++ R+++K+E VLRN +I+T K GV+F+++ + +NE +L +Y+E ++S+++ IM++ Y +H+L+ II++LDVL S A + AP +Y RPK+ + + K+ RHP +E+Q+++ +I ND+ F++ +T F IITGPNMGGKSTYIRSIG+ V+AQIGSF+PC+ AEISI D I+ R+GAGD Q+ GVSTFM EML+ + IL+ ATS SLIIIDELGRGTSTFDGFGLAW+ISE+I+T++KAFS FATHFHELT LS VNNLHVTA ++L +YKV G +S+GI VA+ + P I+ AK K E E + + + EK A
Sbjct: 17 HAFLSFFRSLPDKPASTIRVFDRNDFYTVHESDAVFASKEFFKTSGVIKYLGKEPNKIESVVLSKMNFESIIRDLLLVRHYRVEVYQNKGSNKSND-WKLEFKASPGNLVQFEDILFGNNDMSTCGGVI--SIKVINDNGNKVVGVAYLDNTLHEISVSE--FTDNDKFSNLEALIVQLGPKECLLPSEKNADYTYVKQLTSRNGVLVTERKKSDFTGKSIVQDMNRLLNFKKGDLENSA-ALPGMDKHHAISSLAAIIKYLELLGNDDNFNQYKLSVFDLTRFVRLDGCAVKALNLLPVPGESAKTQSIFGLLNECRTAQGQRLLSRWVNQPLTDLNLIEERLDVVEIFISDHNMTSEIQSDHLKRFPDFQRIAKKFEKKKANLQDMFRIYQAISRLTNLISMLEQYSGEKEHVLNEMFCKPLNELGKQFNKFQKLAESTIDIEKANNGEYVVNPEFDEKLMELRTKLDNLEEKIENVFKKAARDLQLDPQKTIKLENNNQIGFHFRITKKEEKVLRNNKNYRMIQTNKGGVQFNNSALRDLNEEHLSVYGEYQEQQKSVVDAIMQVAMGYAEPMHELNDIISRLDVLLSFAFVAEKAPTSYVRPKLFSKG-SGILKLTQARHPCLEVQDDVKFIPNDVYFEKDKTTFHIITGPNMGGKSTYIRSIGVNVVLAQIGSFIPCESAEISIVDSILARVGAGDSQMKGVSTFMVEMLETAAILRAATSDSLIIIDELGRGTSTFDGFGLAWAISEYISTKIKAFSLFATHFHELTALSDQVSTVNNLHVTALAANDKLTLLYKVNPGVCDQSFGIHVAELAQFPKHVIEFAKRKAKELEGYHDDYTQYDEKSA 860
BLAST of Msh2 vs. TrEMBL
Match: A0A1S3HMF8 (DNA mismatch repair protein Msh2 OS=Lingula unguis OX=7574 GN=LOC106156484 PE=3 SV=1) HSP 1 Score: 650.973 bits (1678), Expect = 0.000e+0 Identity = 342/844 (40.52%), Postives = 534/844 (63.27%), Query Frame = 1
Query: 25 NSFSLFWNSLGDKPNSTIRFFDRQDYYTVHFEDAEMLARSYYKSMEILKYFRRDSVSSPYINISKSNSDGVFKYLLIANQYKVEVYSNNKS--HDSWNLDFVATPGNLEKYQDILFKDVELVSSNSLLGLNIKRINDDYRIFLGFCDLDNGIFMIGGFEESFTGYEQLANLSSALFQLNCRECLIPN-DTRPELLAVKNAVQSAGLLVTEVKKSFFSSENVMNSILKLICKTKLNNENTVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNILPSPND-LRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFD-ESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYENLMEWD 2541
+ F + SL +KPN+TIRFFDR DYYTVH DA A+ +K+ ++K+ + + +SK N + + LL+ QY+VEVY N + ++ W+L + A+PGNL +++D+LF ++ S ++ + + N + +G+ D F + F E+ +Q +NL + + QL +EC++ + + PE+ +K ++ +G+L+TE KK+ FS+++ + + +L+ K K + L + + + + ++I YL+L DE+ F+ F +Q+F L YM++ ALN++PSPN+ K+ S+ GLLN CRT G+RLL QW+KQPL+D N I RL++VES + D +LR L E+ LR++PD QR+ ++ Q+ + NLQD Y++Y AL + +L L +H G + ++ ++ ++E+L D F +M + D + V+NHEF +K D DE L E + ++ Q++ + ++ + L +E K LK ES++ LGY+ R++RK+E VLRN I+T K GV+FH+T + +NE ++ + DY E ++S++ E++ I YV + L+ +IA LD L S A + AP Y RP+++D + ++ RHP +EMQ+++++I ND F+ + + F IITGPNMGGKSTYIRS+G+I +MAQIG FVPC AEIS+ D I+ R+GAGD QL GVSTFMAEML+ + IL+TAT SL+IIDELGRGTST+DGFGLAW+ISE+IAT++ A+ FATHFHELT LS + VNNLHVTA T + L +Y+V+ G +S+GI VA+ + P ++ A+ K E E+ D
Sbjct: 18 HGFLSYLRSLPEKPNTTIRFFDRNDYYTVHGPDAVFAAKEVFKTTGVIKHLGSGANKVESVVLSKLNFESTVRDLLLVRQYRVEVYRNRAAGKNNDWSLAYKASPGNLTQFEDVLFGSNDMSVSVGVIAVKLGTENGQRVVGVGYGDATLRKFGVCQFPEN----DQFSNLEALIVQLGPKECVLASGEGSPEVSRLKQVIERSGVLITERKKADFSTKDNVQDLNRLL-KFKKGEQANSAALAEMDKTHAMAAVSALIKYLELLGDETNFHQFSLQSFDLSQYMKLDAAAVNALNLMPSPNEGSNKNQSVLGLLNRCRTPQGQRLLAQWVKQPLIDKNRIEERLNVVESFVEDTELRQTLQEDQLRKVPDFQRLAKKFQKKRANLQDCYRVYQALEKMPYLLEALEKHQGKHTPLLMELFTNPMKELLMDFSKFQEMVETTIDLDQVENHEFLIKPDFDEGLAELREKLDNVEKQIKAQLNKAAKDLNLEPNKVLKLESNSQLGYFFRLTRKEEKVLRNNKNYRTIDTNKSGVRFHNTPLRQLNEEFIALKDDYNEQQKSVVAEVIAIAAGYVEPMILLNDVIAHLDALVSFAHVSANAPIPYIRPRLLDKG-AGILRLTEARHPCLEMQDDVAFIPNDAIFEKDKKMFHIITGPNMGGKSTYIRSVGVIVLMAQIGCFVPCTEAEISLMDCILARVGAGDSQLKGVSTFMAEMLETASILRTATDTSLVIIDELGRGTSTYDGFGLAWAISEYIATKIGAYCLFATHFHELTALSDVVPTVNNLHVTALTTNDTLTLLYRVKPGVCDQSFGIHVAELAHFPKHVLEFARQKAQELEDYQSID 855
BLAST of Msh2 vs. Ensembl Cavefish
Match: msh2 (mutS homolog 2 [Source:NCBI gene;Acc:103047089]) HSP 1 Score: 634.41 bits (1635), Expect = 0.000e+0 Identity = 346/869 (39.82%), Postives = 536/869 (61.68%), Query Frame = 1
Query: 10 MDELTNS-FSLFWNSLGDKPNSTIRFFDRQDYYTVHFEDAEMLARSYYKSMEILKYFRRDSVSSPYINISKSNSDGVFKYLLIANQYKVEVYSN------NKSHDSWNLDFVATPGNLEKYQDILFKDVELVSSNS-LLGLNIKRINDDYRIFLGFCDLDNGIFMIGGFEESFTGYEQLANLSSALFQLNCRECLIPN-DTRPELLAVKNAVQSAGLLVTEVKKSFFSSENVMNSILKLICKTKLNNENTVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNIL--PSPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFDES-RTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYENLMEWDSNHSEKLAATRNA 2580
MD + S F F++S+ +KP++T+R FDR DYYTVH +DA AR +K+ ++KY S + +SK N + + LL+ QY+VEVY N +K HD W + + A+PGNL ++++ILF L + ++G+ + D R+ +G +D+ + +G E F +Q +NL + L Q+ +EC++P DT +L ++ +Q G+L+++ KK F++++++ + +L+ K + + L + E + CL +VI YL+L +DE+ F F + TF L+ YMR+ +ALN+ S +D SL GLLN CRT G+RL+ QW+KQPL+D N I RLD+VES + D++LR E+ LRR PDL R+ ++LQR NLQD Y++Y A+ Q ++ L H G ++ ++ + S ++ D F +M + D + +HEF VK D +L E SM L+ M++ + + +LG+++ K +K ES+ +GY+ RV+ K+E LRN + ++ K+GV+F +++++ +NE Y++ R +YEE + +I++EI+ I YV L L+ +IA+LD + S A + AP + RP++++ R+ +K RHP VE Q+++++I ND++F + F IITGPNMGGKSTYIR +G+I +MAQIG FVPCD AE+S+ D ++ R+GAGD Q+ GVSTFMAEML+ + IL++AT SLIIIDELGRGTST+DGFGLAW+ISE+IAT LK+F FATHFHELT L++ V NLHVTA T + L +Y+V++G +S+GI VA+ + P I A+ K E E + E + A A
Sbjct: 11 MDSASESGFISFFSSMPEKPDTTLRIFDRTDYYTVHGKDALFTAREVFKTQGVIKYLGSGSRRLEGVVLSKMNFESFVRDLLLVRQYRVEVYRNKAGGKSSKDHD-WQIAYKASPGNLTQFEEILFGGGGLGEGAAGVVGIRLGTGGDGQRV-VGVGYVDSTLRKMGVCE--FPDNDQFSNLEALLVQIGPKECVLPGGDTAGDLGKLRQVIQRGGILLSDRKKMEFTAKDIVQDLNRLL-KARKGETVSSAALPEMEKQIAVSCLAAVIKYLELLSDEANFGSFKLTTFDLNQYMRLDNAAVQALNLFQGSSSDDPTGTHSLAGLLNKCRTPQGQRLVNQWLKQPLIDKNKIEERLDLVESFVEDSELRQSCQEDLLRRFPDLNRLAKKLQRQSANLQDCYRVYQAVGQLPGLVQALERHTGKHQVLLNAAFISPFSDLTSDFSKFQEMIETTLDMNQIDHHEFLVKPSFDPTLSELRESMDQLEKSMQSALNSAARELGLDAGKTIKLESNAQMGYFFRVTCKEEKSLRNNKKFTTLDVQKNGVRFTNSKLSSLNEEYVKSREEYEEAQNAIVKEIIGIAGGYVEPLQTLNEVIAQLDAVVSFAVVSHAAPVPFVRPRILEKGSGRLI-LKGSRHPCVEAQDDVAFIPNDVTFTRGEQMFHIITGPNMGGKSTYIRQVGVIVLMAQIGCFVPCDEAELSVVDCVLARVGAGDSQIKGVSTFMAEMLETAAILRSATEDSLIIIDELGRGTSTYDGFGLAWAISEYIATRLKSFCLFATHFHELTALAQQEPTVCNLHVTALTTDSTLTMLYRVKKGVCDQSFGIHVAELANFPKHVIANAREKALELEEFQDISRAEEEGVDAGPEA 873
BLAST of Msh2 vs. Ensembl Cavefish
Match: msh3 (mutS homolog 3 [Source:NCBI gene;Acc:103037699]) HSP 1 Score: 207.223 bits (526), Expect = 9.774e-55 Identity = 211/817 (25.83%), Postives = 363/817 (44.43%), Query Frame = 1
Query: 334 GNLEKYQDILFKDVELVSSNSLLGL--NIKRINDDYRIFLGFCDLDNGIFMIGGFEESFTGYEQLANLSSALFQLNCRECLIPND-TRPELLAVK----NAVQSAGLLVTEVKKSF-FSSENVMNSILKLIC----KTKLNNENTVLKLVDTEGAETIGCLGSVITYLD-------LANDESFFNFFDVQTFKLDNYMRVGEQCSRALNILPSPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALR---------------QASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMT------LMNESY---LQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEM--QNNMSYIANDISFD-ESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIH-CNVNNLHVT-----AQTIGNE-------LIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYENLMEWDSNHSEKLA-----ATRNALMEF 2592
G+LE+ +D+ V+ ++ L+ + N +++ + + L G M+ F+++ + E L + + ++ E L+P+D + P ++ ++VQ+ + E ++S F M ++ + +T N E + + I CLG VI YL L SF ++M + + L I + SL +L+ T G+RLL +W+ QPL + I +R + V +++ + L R+PDL+R + K + Q+ Y L L Q S L + P V+ E T N ++F DF ++ K Q++ S + +E ++L+ N Y VS ++ + S S++ D VK +ST++ + E Y LQ R +++ ++ L + +A +D SLA + Y RP+V++ + R +++ RHP+++M Y+ ND + + I+TGPNMGGKS+YIR + L+++MAQ+GSFVP A I + D I TR+GA D G STFM E+L+ S IL ATS+SL+I+DELGRGTST DG +A++ E ++K + F TH+ L +L K++ +V N H+ + +G+E + F+Y++ EG A RSYG+ VA+ + +P+ ++ A LK E E ++ + L+ R AL+E+
Sbjct: 335 GDLEQAEDV----VQDPPTSYLMCVSENWDKLSKELTVGLVVVQPSTGDVMLDCFKDNTSRSE----LEARVLKIQPVEILVPSDLSEPTERLLRTIALSSVQADDRIRIEKRESTQFEYPTAMMTVREFYTSRSTRTVKNCEKGSASFYLSLESPVICCLGPVIQYLTEFKLERVLLCPSSFRRLLSD-----SDHMVLSATTMKNLEIFCNQTTGSVKGSLLWVLDHTHTPFGKRLLKKWVSQPLKSASEILSRQEAVAEILSSESSVLPSIQALLNRLPDLERGLCSIYHKKCSTQEFYLLSSTLSRLGIEFQALIPAVQSQISSALLKSLLLDTPQLLSPAHNFLKVLNENAAKTGNKTELFADLTDFPVIEQR----------------------KDQIQNILSDI-----MEHRRELRLILRNPSLNYATVSGQEFLIEVKNSMSSVVPP--DWVKINSTKVVGRYHSPFIVEKYRCLLQLREQLVIDSGQEWINFLQLFGEHYYILKKAVGHLATMDCFFSLAQV--AKENNYCRPEVLE--QERHIVIRDGRHPVIDMLMGEQDQYVPNDTELQGDGKRAMIVTGPNMGGKSSYIRQVALVTIMAQLGSFVPAREASIGMVDGIFTRMGASDNISRGRSTFMEELLEASEILSHATSRSLVILDELGRGTSTHDGIAIAYATLEFFIRDVKCLTLFVTHYPPLCELEKLYPLHVGNYHMAFLLNEPEIVGDEEEVQPEFITFLYQLTEGAAGRSYGLNVARLANIPESILRTAALKSKELEAIINSRRRAVKGLSEAWKITNREALLEW 1105
BLAST of Msh2 vs. Ensembl Cavefish
Match: msh3 (mutS homolog 3 [Source:NCBI gene;Acc:103037699]) HSP 1 Score: 207.223 bits (526), Expect = 9.774e-55 Identity = 211/817 (25.83%), Postives = 363/817 (44.43%), Query Frame = 1
Query: 334 GNLEKYQDILFKDVELVSSNSLLGL--NIKRINDDYRIFLGFCDLDNGIFMIGGFEESFTGYEQLANLSSALFQLNCRECLIPND-TRPELLAVK----NAVQSAGLLVTEVKKSF-FSSENVMNSILKLIC----KTKLNNENTVLKLVDTEGAETIGCLGSVITYLD-------LANDESFFNFFDVQTFKLDNYMRVGEQCSRALNILPSPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALR---------------QASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMT------LMNESY---LQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEM--QNNMSYIANDISFD-ESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIH-CNVNNLHVT-----AQTIGNE-------LIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYENLMEWDSNHSEKLA-----ATRNALMEF 2592
G+LE+ +D+ V+ ++ L+ + N +++ + + L G M+ F+++ + E L + + ++ E L+P+D + P ++ ++VQ+ + E ++S F M ++ + +T N E + + I CLG VI YL L SF ++M + + L I + SL +L+ T G+RLL +W+ QPL + I +R + V +++ + L R+PDL+R + K + Q+ Y L L Q S L + P V+ E T N ++F DF ++ K Q++ S + +E ++L+ N Y VS ++ + S S++ D VK +ST++ + E Y LQ R +++ ++ L + +A +D SLA + Y RP+V++ + R +++ RHP+++M Y+ ND + + I+TGPNMGGKS+YIR + L+++MAQ+GSFVP A I + D I TR+GA D G STFM E+L+ S IL ATS+SL+I+DELGRGTST DG +A++ E ++K + F TH+ L +L K++ +V N H+ + +G+E + F+Y++ EG A RSYG+ VA+ + +P+ ++ A LK E E ++ + L+ R AL+E+
Sbjct: 335 GDLEQAEDV----VQDPPTSYLMCVSENWDKLSKELTVGLVVVQPSTGDVMLDCFKDNTSRSE----LEARVLKIQPVEILVPSDLSEPTERLLRTIALSSVQADDRIRIEKRESTQFEYPTAMMTVREFYTSRSTRTVKNCEKGSASFYLSLESPVICCLGPVIQYLTEFKLERVLLCPSSFRRLLSD-----SDHMVLSATTMKNLEIFCNQTTGSVKGSLLWVLDHTHTPFGKRLLKKWVSQPLKSASEILSRQEAVAEILSSESSVLPSIQALLNRLPDLERGLCSIYHKKCSTQEFYLLSSTLSRLGIEFQALIPAVQSQISSALLKSLLLDTPQLLSPAHNFLKVLNENAAKTGNKTELFADLTDFPVIEQR----------------------KDQIQNILSDI-----MEHRRELRLILRNPSLNYATVSGQEFLIEVKNSMSSVVPP--DWVKINSTKVVGRYHSPFIVEKYRCLLQLREQLVIDSGQEWINFLQLFGEHYYILKKAVGHLATMDCFFSLAQV--AKENNYCRPEVLE--QERHIVIRDGRHPVIDMLMGEQDQYVPNDTELQGDGKRAMIVTGPNMGGKSSYIRQVALVTIMAQLGSFVPAREASIGMVDGIFTRMGASDNISRGRSTFMEELLEASEILSHATSRSLVILDELGRGTSTHDGIAIAYATLEFFIRDVKCLTLFVTHYPPLCELEKLYPLHVGNYHMAFLLNEPEIVGDEEEVQPEFITFLYQLTEGAAGRSYGLNVARLANIPESILRTAALKSKELEAIINSRRRAVKGLSEAWKITNREALLEW 1105
BLAST of Msh2 vs. Ensembl Cavefish
Match: msh4 (mutS homolog 4 [Source:ZFIN;Acc:ZDB-GENE-131121-643]) HSP 1 Score: 188.734 bits (478), Expect = 1.906e-49 Identity = 109/261 (41.76%), Postives = 150/261 (57.47%), Query Frame = 1
Query: 1741 LHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFDESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNE------LIFMYKVEEG-PAVRSYGIEVAKASGLPDESIKLAK 2502
L++LS ++ LD+L SLA C Y RP+ D +K RHP +E I+N+ E F I+TGPNM GKSTY+R + L +MAQIGSFVP + A + D+I TRIG D T STFM EM ++S+I TA+ +SLIIIDELGRGTS +G G+ ++ E + LKAF+ FATH+ EL L ++ NV N H+ Q I E +++ Y + G R+YGI A+ + +P I+ AK
Sbjct: 457 LYKLSDAVSMLDMLLSLAN-ACTL-SDYVRPEFTD-----TLAIKQGRHPTLERITGKQPISNNSYISEGSNFVIVTGPNMSGKSTYLRQVALCQIMAQIGSFVPAEYASFRVADQIFTRIGVDDDFETNSSTFMVEMKEVSYITHTASERSLIIIDELGRGTSAEEGIGICHAVCEFL-INLKAFTLFATHYLELCQLETLYPNVENQHMQVQHIRREDNSTESVVYTYLLTRGFSEERNYGIRAAEMTSMPPSIIQEAK 709
BLAST of Msh2 vs. Ensembl Cavefish
Match: msh3 (mutS homolog 3 [Source:NCBI gene;Acc:103037699]) HSP 1 Score: 189.119 bits (479), Expect = 5.975e-49 Identity = 113/316 (35.76%), Postives = 177/316 (56.01%), Query Frame = 1
Query: 1720 TNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGT----YARPKVVDDCKTRVFKVKNCRHPLVEM--QNNMSYIANDISFD-ESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIH-CNVNNLHVT-----AQTIGNE-------LIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYENLMEWDSNHSEKLA-----ATRNALMEF 2592
+ K VG H I+ K L L + G + +P+V++ + R +++ RHP+++M Y+ ND + + I+TGPNMGGKS+YIR + L+++MAQ+GSFVP A I + D I TR+GA D G STFM E+L+ S IL ATS+SL+I+DELGRGTST DG +A++ E ++K + F TH+ L +L K++ +V N H+ + +G+E + F+Y++ EG A RSYG+ VA+ + +P+ ++ A LK E E ++ + L+ R AL+E+
Sbjct: 757 STKVVGRYHS-PFIVEKYRCLLQLREQLVIDSGQEWINFLQPEVLE--QERHIVIRDGRHPVIDMLMGEQDQYVPNDTELQGDGKRAMIVTGPNMGGKSSYIRQVALVTIMAQLGSFVPAREASIGMVDGIFTRMGASDNISRGRSTFMEELLEASEILSHATSRSLVILDELGRGTSTHDGIAIAYATLEFFIRDVKCLTLFVTHYPPLCELEKLYPLHVGNYHMAFLLNEPEIVGDEEEVQPEFITFLYQLTEGAAGRSYGLNVARLANIPESILRTAALKSKELEAIINSRRRAVKGLSEAWKITNREALLEW 1069
BLAST of Msh2 vs. Ensembl Sea Lamprey
Match: msh2 (mutS homolog 2 (E. coli) [Source:ZFIN;Acc:ZDB-GENE-040426-2932]) HSP 1 Score: 216.083 bits (549), Expect = 3.627e-63 Identity = 121/347 (34.87%), Postives = 198/347 (57.06%), Query Frame = 1
Query: 25 NSFSLFWNSLGDKPNSTIRFFDRQDYYTVHFEDAEMLARSYYKSMEILKYF-RRDSVSSPYINISKSNSDGVFKYLLIANQYKVEVYSNNKSHDS----WNLDFVATPGNLEKYQDILFKDVELVSSNSLLGLNIKRINDDYRIFLGFCDLDNGIFMIGGFEESFTGYEQLANLSSALFQLNCRECLIP-NDTRPELLAVKNAVQSAGLLVTEVKKSFFSSENVMNSILKLICKTKLNNENTVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNILPSPND-LRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNR 1044
N F F+ S+ +K +T+R FDR D+YTVH DA +++R +K+ ++K S + +SK N + V + LL+ QY+VEVY N S W L + A+PGNL +++DILF +V++ +S ++ + + + +GF D + F ++ +Q +NL + L QL +EC++P + + + ++ VQ +GLL+T+ KK FSS++++ + +L+ KT+ + L + E + L +++ YL+L +DES F F++ TF L Y+R+ RALN+ +D + SL+GLLN CRTA G+RLL QWIKQPL+D N I R
Sbjct: 18 NGFVSFFASMSEKAEATVRLFDRADFYTVHGRDALLVSRDVFKTTAVVKMLGTAGSRKLESVVLSKMNFESVVRDLLLVRQYRVEVYRNRAGKASRDNDWQLAYKASPGNLAQFEDILFGNVDMSASAGVVAIQGGGADAQRVVGVGFADTTLRRLCVCEFPDN----DQFSNLEALLVQLGPKECVLPAGEVQADAGKLRQVVQRSGLLITDRKKVEFSSKDIVQDLNRLL-KTRKGEQANSAALSEMEKQVAMSSLAALVKYLELTSDESGFGQFELSTFDLGQYVRLDSAAVRALNLFQGSSDEGGRTQSLFGLLNRCRTAQGQRLLAQWIKQPLLDQNRIEER 359
BLAST of Msh2 vs. Ensembl Sea Lamprey
Match: msh3 (mutS homolog 3 (E. coli) [Source:ZFIN;Acc:ZDB-GENE-060526-307]) HSP 1 Score: 204.912 bits (520), Expect = 5.050e-55 Identity = 193/716 (26.96%), Postives = 324/716 (45.25%), Query Frame = 1
Query: 529 LSSALFQLNCRECLIP---NDTRPELLAVKNAVQSAG---LLVTEVKKSFFSSENVMNSILKLICKTKL----NNENTVLKLVDTEGAETIGCLGSVITYL-DLANDESFFNFFDVQTFKLDNY-MRVGEQCSRALNILPSPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQ----ASDMLNLLNEHNGPYKCIIQSELSS-VIQEILKDTE---NFIQMFTSFFDFEAVKNHE----FKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENV-LRNKSFISI------IETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKL---DVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVE--MQNNMSYIANDISFD-ESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCN-VNNLHV---------TAQTIGNE----LIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYE 2523
L S + L E LIP +D L A S G + V V F ++ + L N++ L V I CL +I YL + + + + Q F +++ + + + + + + + + SL ++ T G R+ W+ +PL+ ++ IN RLD V ++ + +E L ++PDL+R L IY + ++ AS + L E + Q +LSS ++ IL D +Q +T D +A K + F L+ E L+ E + E + L+ +++ Y VS ++ + +RN ++ I + K +FH+ + + + Q + E+ E + ++ H + +A+L D L SLA + RP+ V++ + ++N RHP+VE M + Y+ N D + + IITGPNMGGKS+YIR + LI+VMAQ+GSFVP A++S I TR+GA D G STFM E+ + S I++ AT SL+I+DELGRGTST DG +A++ E+ E++ + F TH+ + ++ +++ V+N H+ TAQ E + F+Y++ EGPA RSYG+ VA+ + +P++ + A K E E
Sbjct: 210 LESRVLSLQPVELLIPAALSDETERSLCSLTANSSQGDDRVRVERVDVDLFEHSRAFQAVSRFFGAESLQSNCNHDEQKLSHVLAMEKPIIACLAVLIHYLTEFGLERVLYLSSNFQKFSMESECLHINGITQKNMELFQNQTNGKVKGSLLWAMDRTCTPFGRRMFRNWLGRPLISISDINARLDCVSEILASEHMVLSRAKELLWKLPDLER----------GLTSIYHRKCSTKEFSLIASSLERLCTETHA-LAASAQDQLSSPLLLGILLDVPRRLQHVQHYTRVLDKQAAKEGDKTRLFTDLTGFPRMLRRSEEIRAVLEELREHRT---------EVRRTLRSPAAD----YTTVSGQEFLIEVRNSMLHTVPSNWVKIGSTKAVTRFHTP---FVVQKFKQLCQLREKLRIDSNAEWLGFLTQFGEHYHNFRAAVAQLATLDCLFSLAAIASRDGYCSIRPEFVEE--KSLIVIENGRHPVVELLMGDQNQYVPNSTHLDADGKRAMIITGPNMGGKSSYIRQVALIAVMAQMGSFVPASHAKLSSLHAIHTRMGASDNIYKGHSTFMEELSEASEIIRKATRHSLVILDELGRGTSTHDGIAIAYATLEYFVKEVQCLTLFVTHYPPVCEMERLNAEVVSNYHMSFLLSEPEETAQGEDGERLESVTFLYQLTEGPAARSYGLNVARLAAIPEQVLHTAAQKSRELE 896
BLAST of Msh2 vs. Ensembl Sea Lamprey
Match: msh6 (mutS homolog 6 (E. coli) [Source:ZFIN;Acc:ZDB-GENE-020905-3]) HSP 1 Score: 143.28 bits (360), Expect = 5.259e-35 Identity = 86/253 (33.99%), Postives = 133/253 (52.57%), Query Frame = 1
Query: 1864 FKVKNCRHPLVEMQN-NMSYIANDISFDESRTFQ-------IITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGD-----CQLTGVSTFMAEMLDISWILKTATSKSLIIIDEL-------GRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTD---------LSKIHCNV---NNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYEN 2526
+++ RHP V S+I ND+ S ++TGPNMGGKST +R GLI +MAQ+G +VP + ++ DR+ TR+GA D + G STF E+ + S IL+ AT SL+++DEL GRGT+T+DG +A ++ +A ++ + F+TH+H L + L + C V N+ + +TI F+YK G +SYG A+ +GLPD ++ K E+E+
Sbjct: 1121 LELRGSRHPCVSTTFLGDSFIPNDVVVGLSDGDDDGGARCVLVTGPNMGGKSTLMRQAGLIVIMAQLGCYVPAEACRLTPVDRVFTRLGASDRIMSVLRRAGESTFFVELSETSSILQHATRHSLVLLDELGFLLRPRGRGTATYDGTAIASAVVHELAEGVRCRTLFSTHYHSLVEDFAASPHVRLGHMACMVEQENDDDPSQETI----TFLYKFVAGACPKSYGFNAARLAGLPDAVVRAGHRKAREFES 1369
BLAST of Msh2 vs. Ensembl Yeast
Match: MSH2 (Protein that binds to DNA mismatches; forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP [Source:SGD;Acc:S000005450]) HSP 1 Score: 481.485 bits (1238), Expect = 4.165e-156 Identity = 304/878 (34.62%), Postives = 497/878 (56.61%), Query Frame = 1
Query: 43 WNSLGDKPNSTIRFFDRQDYYTVHFEDAEMLARSYYKSMEILKYFRRDSVSSP-------YINISKSNSDGVFKYLLIANQYKVEVYSNNKSHDSWNLDFVATPGNLEKYQDILFKDVELVSSNSLLGLNIKRINDDYRIFLGFCDLDNGIFMIGGFEESFTGYEQLANLSSALFQLNCRECLIPN-----DTRPELLAVKNAVQSAGLLVTEVKKSFFSSENVMNSILKLICKTKLNNENTVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNILP------------------SPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLN---EHNGPYKCI---IQSELSSVIQEILKDTENFIQMFTSFFDFEAVK-NHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLR-NKSFISIIETLKDGVKFHSTQM-TLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFDESR-TFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGN---------ELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYENL 2529
+ L KP TIR D+ DYYTV DA +A S Y + +LK + D V++ Y+ +S + K L+ YKVE+Y W L A+PGN+E+ +++ +++ SS + L ++ + D +G +D + +G + E +NL S L QL +ECL+ + ++ E+ V N + G +VT +K S FS ++V + TKL ++ L L ++G ++I YL L +++ +++ KL +M++ +ALN+ P S + K SL+ LLN C+T +G RLL +W+KQPL +++ IN R D+V+ LI+ +LR L E L IPD++R+T++L + +GNL+D+ K+Y ++ +++ + E + P + + ++S + + ++ F +M + D +A + N+EF +K + +E L + + + TL+ ++ + ++ LG + K+LK E+ + G+ MR++R D LR +K +I + T+K G+ F + Q+ ++ NE+ + + ++ + E + IT Y +LS ++A LDV+ S A AP Y RPK+ R + + RHP++EMQ+++S+I+ND++ + + F IITGPNMGGKSTYIR +G+IS+MAQIG FVPC+ AEI+I D I+ R+GAGD QL GVSTFM E+L+ + ILK A+ SLII+DELGRGTST+DGFGLAW+I+EHIA+++ F+ FATHFHELT+LS+ NV N+HV A N ++ +YKVE G + +S+GI VA+ P++ +K+AK K +E ++L
Sbjct: 23 YTGLPKKPLKTIRLVDKGDYYTVIGSDAIFVADSVYHTQSVLKNCQLDPVTAKNFHEPTKYVTVSLQVLATLLKLCLLDLGYKVEIYDK-----GWKLIKSASPGNIEQVNELMNMNID--SSIIIASLKVQWNSQDGNCIIGVAFIDTTAYKVGMLD--IVDNEVYSNLESFLIQLGVKECLVQDLTSNSNSNAEMQKVINVIDRCGCVVTLLKNSEFSEKDVELDL------TKLLGDDLALSLPQKYSKLSMGACNALIGYLQLLSEQDQVGKYELVEHKLKEFMKLDASAIKALNLFPQGPQNPFGSNNLAVSGFTSAGNSGKVTSLFQLLNHCKTNAGVRLLNEWLKQPLTNIDEINKRHDLVDYLIDQIELRQMLTSEYLPMIPDIRRLTKKLNK-RGNLEDVLKIYQFSKRIPEIVQVFTSFLEDDSPTEPVNELVRSVWLAPLSHHVEPLSKFEEMVETTVDLDAYEENNEFMIKVEFNEELGKIRSKLDTLRDEIHSIHLDSAEDLGFDPDKKLKLENHHLHGWCMRLTRNDAKELRKHKKYIEL-STVKAGIFFSTKQLKSIANETNILQKEYDKQQSALVREI-INITLTYTPVFEKLSLVLAHLDVIASFAHTSSYAPIPYIRPKLHPMDSERRTHLISSRHPVLEMQDDISFISNDVTLESGKGDFLIITGPNMGGKSTYIRQVGVISLMAQIGCFVPCEEAEIAIVDAILCRVGAGDSQLKGVSTFMVEILETASILKNASKNSLIIVDELGRGTSTYDGFGLAWAIAEHIASKIGCFALFATHFHELTELSEKLPNVKNMHVVAHIEKNLKEQKHDDEDITLLYKVEPGISDQSFGIHVAEVVQFPEKIVKMAKRKANELDDL 882
BLAST of Msh2 vs. Ensembl Yeast
Match: MSH3 (Mismatch repair protein; forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability [Source:SGD;Acc:S000000688]) HSP 1 Score: 207.994 bits (528), Expect = 5.512e-56 Identity = 180/582 (30.93%), Postives = 295/582 (50.69%), Query Frame = 1
Query: 898 LNILPSPNDLRK-----HD----SLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRI----PDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQS-------------ELSSVIQEILKDTENFIQMFTSFFDFEAV--KNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSN---SLGYYMRVSR---KD-------ENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFD-ESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELK--AFSAFATHFHELTDL-SKIHCNVNNLHVTAQTIGNE---LIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLA 2499
+++L PN L+ HD SL+ LL+ RT+ G R+L +WI +PL+DV+ I RLD +E + ++ + ++ E+L ++ PDL R R+ + +++Y L+Q + ++ H +S L S + E+L T+ + F + + AV KN + +V + + +C +I ++ + E+ S++ ++L E K LK N + Y + V KD N + S + T K K + L+ ES LQ++ KIT +Y L +++ +A+ D + SLA C Y RP V+ + + KN R+P++E + + Y+ NDI E+ IITGPNMGGKS+YIR + L+++MAQIGSFVP + +SIF+ ++TRIGA D + G STF EMLDI ILK +SL+++DE+GRGT T DG +++++ ++ + EL F THF L ++ S + N + +V Q G + +IF+YK+++G SYG+ VAK + L + I A
Sbjct: 416 IHMLLDPNSLQSLDIFTHDGGKGSLFWLLDHTRTSFGLRMLREWILKPLVDVHQIEERLDAIECITSE--INNSIFFESLNQMLNHTPDLLRTLNRIMYGTTSRKEVY---FYLKQITSFVDHFKMHQSYLSEHFKSSDGRIGKQSPLLFRLFSELNELLSTTQ--LPHFLTMINVSAVMEKNSDKQVMDFFNLNNYDCSEGIIKIQRESESVRSQLKEELA-EIRKYLKRPYLNFRDEVDYLIEVKNSQIKDLPDDWIKVNNTKMVSRFTTPRTQKLTQKLEYYKDLLIRESELQYKEFLN-----------KITAEYT-ELRKITLNLAQYDCILSLAATSCNV--NYVRPTFVNGQQAII--AKNARNPIIESLD-VHYVPNDIMMSPENGKINIITGPNMGGKSSYIRQVALLTIMAQIGSFVPAEEIRLSIFENVLTRIGAHDDIINGDSTFKVEMLDILHILKNCNKRSLLLLDEVGRGTGTHDGIAISYALIKYFS-ELSDCPLILFTTHFPMLGEIKSPLIRNYHMDYVEEQKTGEDWMSVIFLYKLKKGLTYNSYGMNVAKLARLDKDIINRA 971
BLAST of Msh2 vs. Ensembl Yeast
Match: MSH6 (Protein required for mismatch repair in mitosis and meiosis; forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; also involved in interstrand cross-link repair; potentially phosphorylated by Cdc28p [Source:SGD;Acc:S000002504]) HSP 1 Score: 160.614 bits (405), Expect = 9.888e-41 Identity = 97/286 (33.92%), Postives = 151/286 (52.80%), Query Frame = 1
Query: 1762 IAKLDVLCSLA--TMVCGAPGTYARPKVVDDCKTRV-------FKVKNCRHPLVEMQNNMS--YIANDISF-DESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVT--AQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYENLMEWDSNHSEKLAATRN 2577
I+ +D L ++ + GAP RP +VD+ ++ K K+ RHP + + +I NDI E ++TG N GKST +R + +MAQ+G +VPC+ A ++ DRIMTR+GA D + G STF E+ + IL AT++SL+++DELGRG S+ DGF +A S+ H+AT +++ FATH+ L K H V L ++ + F+YK+ EG + S+G+ VA G+ E I A++ E H+ +L R+
Sbjct: 902 ISNIDCLLAITRTSEYLGAPS--CRPTIVDEVDSKTNTQLNGFLKFKSLRHPCFNLGATTAKDFIPNDIELGKEQPRLGLLTGANAAGKSTILRMACIAVIMAQMGCYVPCESAVLTPIDRIMTRLGANDNIMQGKSTFFVELAETKKILDMATNRSLLVVDELGRGGSSSDGFAIAESVLHHVATHIQSLGFFATHYGTLASSFKHHPQVRPLKMSILVDEATRNVTFLYKMLEGQSEGSFGMHVASMCGISKEIIDNAQIAADNLE--------HTSRLVKERD 1177 HSP 2 Score: 56.9954 bits (136), Expect = 1.414e-8 Identity = 39/144 (27.08%), Postives = 71/144 (49.31%), Query Frame = 1
Query: 898 LNILPSPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMF 1329
L I + D +L+ L N T G+R++ +W+ PL+ N I +RLD V+SL+ D LR L E ++PDL+R+ R+ ++D K+ A ++ + L N K + +SS + +++ +++ F
Sbjct: 624 LEIFSNSFDGSDKGTLFKLFNRAITPMGKRMMKKWLMHPLLRKNDIESRLDSVDSLLQDITLREQL-EITFSKLPDLERMLARIHSRTIKVKDFEKVITAFETIIELQDSLK--NNDLKGDVSKYISSFPEGLVEAVKSWTNAF 764
BLAST of Msh2 vs. Ensembl Yeast
Match: MSH1 (DNA-binding protein of the mitochondria; involved in repair of mitochondrial DNA; has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis [Source:SGD;Acc:S000001162]) HSP 1 Score: 147.902 bits (372), Expect = 8.228e-37 Identity = 91/266 (34.21%), Postives = 149/266 (56.02%), Query Frame = 1
Query: 1741 LHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVE----MQNNMSYIANDISFDESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHF-HELTDLSKIHCNVN-----NLHVTAQTI--GNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAK 2502
+ Q+++ + LD L S A V PKV + K +V N RH +VE ++ ++ AN+ + + +ITGPNMGGKST++R +I ++AQIG FVPC A + I D++ +R+G+ D +STFM EM++ S+IL+ AT +SL I+DE+GRGTS +G +A++ +++ + + FATHF EL + C+ + + T GN + +K++ G +S I VA+ +G P E++K A+
Sbjct: 696 VRQVATTLGYLDTLSSFA--VLANERNLVCPKVDESNK---LEVVNGRHLMVEEGLSARSLETFTANNCELAKDNLW-VITGPNMGGKSTFLRQNAIIVILAQIGCFVPCSKARVGIVDKLFSRVGSADDLYNEMSTFMVEMIETSFILQGATERSLAILDEIGRGTSGKEGISIAYATLKYLLENNQCRTLFATHFGQELKQIIDNKCSKGMSEKVKFYQSGITDLGGNNFCYNHKLKPGICTKSDAIRVAELAGFPMEALKEAR 955 HSP 2 Score: 51.9878 bits (123), Expect = 4.252e-7 Identity = 45/179 (25.14%), Postives = 82/179 (45.81%), Query Frame = 1
Query: 868 MRVGEQCSRALNILPSPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAV-KNHEFKVKCDVDESL 1401
M++ + S AL + + D K SL + T SG RLL QW+ P +D+ I R IV + DN+ L+++ DL RI ++ +G ++ ++ +L + ++ L + K ++S+++ + E L +N I F + E + K+ + K DV L
Sbjct: 363 MQIDSRTSTALELHSTVRDNNKKGSLLSSIRRTVTPSGTRLLSQWLSGPSLDLKEIKKRQKIV-AFFKDNRDITETLRTMLKKVNDLSRILQKFSFGRGEALELIQMARSLEVSREIRKYLLNNTSLMKATLKSQITQ-LTESLNFEKNLIDDILKFLNEEELAKSQDAKQNADVTRML 539
BLAST of Msh2 vs. Ensembl Yeast
Match: MSH4 (Protein involved in meiotic recombination; required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein [Source:SGD;Acc:S000001891]) HSP 1 Score: 136.346 bits (342), Expect = 2.788e-33 Identity = 148/579 (25.56%), Postives = 270/579 (46.63%), Query Frame = 1
Query: 826 FNFFDVQTFKLDNYMRVGEQCSRALNILPSPNDLRKHD-SLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESL-INDNKLRGCLYEENLRRIPDLQRITRRLQ-------RNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTE--NFIQMFTSFFDFEAV-KNHEFKVKCDVDESLKECENSMITLKSQMETESS----RVSDKLGIESTKQLKFESSNSLGYYMRVSRK---DENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXM--KITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVE--MQNNMSYIANDIS-FDESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEH-IATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNELIFM-YKV-EEGPAVRSYGIEVAKASGLPD 2481
F +Q +N M + + R L ++ N L K+ SL+ L+ T G+R L I QPL D I RL+ +E L ND+ L+ E ++ +PDL ++ RL + + + L L+ + + LN+ +IQS L S ++I + ++ S + + V + ++ ++K N ++ + Q+ E R + L ++ L ++ G+Y+R+ R+ D+ FIS T+K +T + + L+ + + + KI ++ L ++ +A LD++CS + Y P ++ +++ RHPL+E ++N ++ N IS S + QIITG NM GKS Y++ + LI +MAQ+GS +P +F R+ R+ +LT S F EM ++++ L +++L+I+DELGRG+S DGF ++ +++EH + TE F +THF ++ + V++LH+ A + + + M Y++ ++ A+ + GI V K PD
Sbjct: 251 FRKLRIQFEGTENTMLIDSKTVRGLELVE--NKLDKNGISLWKFLDTTSTKMGQRSLRNSILQPLTDRGSIEMRLEALEELKANDDLLQKLRLE--MKSLPDLDKLFSRLLCINHSAIKPDQRINYVLLLKETLQSVKSLKDALNDQ------LIQSRLISETKKIFNNDAIMEIEKLINSCINEDCVWASSAIQLLNQRSYAVKSDSNGLLDVSRQIYKEVKEEFFREVEDLTAKNKINLDHNYDSARGFYLRIKRQEFTDDVATLPDVFIS--RTIKKNYIECTTLNIIKKNARLKEVMEEILLLSEETVDELLDKIAT-HISELFMIAEAVAILDLVCSFTYNL--KENNYTIPIFTNN-----LLIRDSRHPLLEKVLKN---FVPNTISSTKHSSSLQIITGCNMSGKSVYLKQVALICIMAQMGSGIPALYGSFPVFKRLHARVCNDSMELTS-SNFGFEMKEMAYFLDDINTETLLILDELGRGSSIADGFCVSLAVTEHLLRTEATVF--LSTHFQDIPKIMSKKPAVSHLHMDAVLLNDNSVKMNYQLTQKSVAIENSGIRVVKKIFNPD 803
BLAST of Msh2 vs. Ensembl Nematostella
Match: EDO38319 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SD83]) HSP 1 Score: 531.176 bits (1367), Expect = 7.317e-177 Identity = 282/679 (41.53%), Postives = 423/679 (62.30%), Query Frame = 1
Query: 502 FTGYEQLANLSSALFQLNCRECLIPN-DTRPELLAVKNAVQSAGLLVTEVKKSFFSSENVMNSILKLICKTKLNNENTVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNILPSPNDL-RKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFD-ESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYENL 2529
F +Q +NL + + QL +ECL+ + D+ + V+ + +LVTE KK FS+++++ + +L+ T N T L + + L +VI YL+L +DES F+ F + +F L YM++ RALN+LP+P D K L GLLN C+T G+RL+ QWIKQPLMD N I RL+IVE+ + D +LR L +E +++ PD R+ ++ QR K LQD ++Y ++++ ++L ++G ++ ++ + E++ D F + + D E V+NHE+ +K DE L+EC M + + E ++ L +E +K +K ES+N LGY+ R++RK+E VLRN S IET KDGV+F ++ ++ +N+ + ++ Y + + + E++KI Y + LS +IA++D L S A + AP Y RP + + RHP +E+Q+N+++IAND++ + + F IITGPNMGGKSTYIR IG+I +MAQ+G FVPC A+ISI D I+ R+G+GD QL GVSTFM+EML+ + IL+TAT SLIIIDELGRGTST+DGFGLAW+ISE+IAT++K+F FATHFHELT L+ V NLHVTA T G L +YKV+ G +S+GI VA+ + P + I+ AK K +E E+
Sbjct: 38 FADNDQFSNLEALIVQLGPKECLMASTDSSGDAAKTHEVVKRSNILVTERKKVEFSNKDIVQDLNRLLKLTAGGNSAT---LPEMDMIHATAALAAVIKYLELLSDESNFSQFKLSSFDLSQYMKLDAAAVRALNLLPNPMDGGNKSMCLTGLLNKCKTPQGQRLVAQWIKQPLMDKNKIEERLNIVEAFVEDTELRQTLQDE-MKKFPDFSRLAKKFQRQKATLQDCVRVYQSVQRLEPFADVLERYHGDHRKLLVECFRDPLMELVADFAKFCDLVETTIDLEQVENHEYLIKATFDEGLQECREHMDEILEKFPVELNKAGRDLSLEPSKTIKLESNNQLGYFFRITRKEEKVLRNNKRYSTIETRKDGVRFTNSALSQLNDEFRGYKDTYNDVQGKLAAEVLKIAGGYSEPMQGLSDVIAQIDALVSFAHVSANAPIPYVRPTITPKGSEGDIILTGSRHPCLEIQDNVAFIANDVTLSRDKQMFLIITGPNMGGKSTYIRQIGVIVLMAQLGCFVPCSTAQISITDCILARVGSGDSQLKGVSTFMSEMLETASILRTATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATQIKSFCLFATHFHELTSLADEVSTVTNLHVTALTTGGTLTLLYKVKPGVCDQSFGIHVAELAHFPSDVIEFAKQKAAELEDF 712
BLAST of Msh2 vs. Ensembl Nematostella
Match: EDO26509 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7TBU4]) HSP 1 Score: 196.052 bits (497), Expect = 9.019e-57 Identity = 107/269 (39.78%), Postives = 164/269 (60.97%), Query Frame = 1
Query: 1729 YVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMS--YIANDISFDESRTFQI-ITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATEL-KAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYE 2523
+V + Q ++ IA+LD L S A Y RP ++D+ ++KN RHP++E Q + YIAND+ + ++ I ITGPNM GKS +R LI ++AQ+GS+VP A I I D+I TR+GA D G STFM EM + + IL + +SL+++DE+GRGTST+DG +AW+I+E + KA + FATH+HEL D+++ + N +V+ + + + +IF+ K+ G + S+GI VAK +G+P+ I A L + E
Sbjct: 1 FVQPVQQNANSIAQLDCLLSFAKTAID--NNYVRP-ILDESTD--LEIKNGRHPVIEKQLPIGEEYIANDVVLNRNQQQIIMITGPNMSGKSAILRQTALIVLLAQMGSYVPAQNARIGIVDKIFTRVGASDNISMGESTFMVEMNETASILNNISERSLVLLDEIGRGTSTYDGISIAWAIAEFLHEHPSKAKTLFATHYHELNDMTETFERIKNYNVSVKELKDTIIFLRKLVAGGSNHSFGIHVAKLAGMPNRVIHRASKILEQLE 264
BLAST of Msh2 vs. Ensembl Nematostella
Match: EDO38799 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SBW8]) HSP 1 Score: 199.519 bits (506), Expect = 4.817e-53 Identity = 174/587 (29.64%), Postives = 277/587 (47.19%), Query Frame = 1
Query: 856 LDNYMRVGEQCSRALNILPSPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVE---SLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDES----LKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENV-LRNKSFISI------IETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVE--MQNNMSYIANDISFD-ESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHC-NVNNLHVTAQTIGNE------------LIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYEN 2526
+ +M++ + L IL S RK SL G+L+ T G+RLL +WI QPL++ I RL V +L +D L ++ L IPDL++ + K + + + AL + D L E N + S LS E+ D + ++ F + D +A K + K K D S + C + L ++++ S + + S Y VS + + +RN S+ I K +F + + +S Q R + + E + I + H+ ++A LD + SLAT V PG Y P + + + + RHP+++ +Q + Y+ N+ + E IITGPNMGGKS+YI+ + LI +MAQ+GSFVP E++ D I TR+GA D G STFM E+ + S IL AT +SL+I+DELGRGTST DG +A++ H + + + F TH+ L +L +I +V N H+ T + + F+Y++ G A RSYG+ VA+ +G+P + +A K + E+
Sbjct: 313 IAKFMKLNGCALQNLEILKSQCGSRK-GSLLGILDHTSTPFGKRLLKRWITQPLLEKREIEERLKAVSCLSALSSDQPLLKSIHR-LLSHIPDLEKGLCAIYYKKCSTVEFLSIAKALSKLHDELKS-TELNSAKELAGSSILSRTFTEV-PDLLSGVEDFLNQIDEKAAKCGD-KTKLFTDPSKFPPVLTCIQEIDGLTAELKEHRSEIRRTIQHPSVD------------YCTVSGNEFLIEVRNAKLPSVPADWIKISATKQICRFRTPFVEEKFKSICQWREKLAQACQEAWLEFLDIFSTSYTRFHRAVKLVANLDCIMSLAT-VARQPG-YVCPVIKKETEASSVLITQGRHPVIDVLLQEHAQYVPNNTELNTEGPRCMIITGPNMGGKSSYIKQVALIVLMAQMGSFVPAHSVELTPLDAIYTRMGASDNIYKGRSTFMVELQETSEILAQATRRSLVILDELGRGTSTHDGVAIAYATLRHFIDQTHSLTLFVTHYPSLAELERIFPGHVTNNHMAFMTSDGDTELASVAMDTPAVTFLYELVRGVAARSYGLNVARLAGIPINIVAMAAGKSHDLES 880
BLAST of Msh2 vs. Ensembl Nematostella
Match: EDO35291 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SM04]) HSP 1 Score: 183.726 bits (465), Expect = 6.790e-48 Identity = 146/518 (28.19%), Postives = 258/518 (49.81%), Query Frame = 1
Query: 889 SRALNILPSPNDLRKHDSLYGLLNCCRTASGER----LLLQWIKQPLMDVNLINNRLDIVESLINDNKLRG-CLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDML--NLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEF--KVKC---DVDESLKECENSMITLKSQMETES-SRVSD---KLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSF---ISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFDESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQT 2385
++ L ++ + D + SL+G+LN RTA G + + L I + L N ++ ++ + L C+ + + + K L+ I L AL+ L P I ++ SVI + + + + M T AVK + K +C D S+ C ++ + + TE+ ++D +L + LK +N+ G+++++ E + S + + +K+ + F + + +N+ + + ++ E++ +G L++L+ +++ LD+L S A +C Y RP+ D +K RHP+++ + + + N++ E F IITGPNM GKSTY++ I L+ VMAQIG +VP + A + D+I +RIG+ D T STFM EM +I++I++ A+ KSLII+DELGRGTS+ +G G+ +++ EH+ +KAF+ FATHF ELT + +++ NV NLH Q+
Sbjct: 260 AKNLELIQNVRDAKSEHSLFGVLNYTRTAGGNKETINMRLDCIAELTEKEELFYNIQTVIGRFLDVDHLTSMCVQIPKHETVKTAESKINTVIYLKHTLELIEPLQSALKDTDTPLFKAYFESLKDPRFTAIMEKIQSVIHDDTRYQKGALNMRTQ--KCFAVKYEQTVEKYECMCLDFRPSVVRCPVGLLDVARRTYTETVDDITDLIKQLAEKYELPLKVGFNNTRGFFIQMQLSKEQDVDTSSLPGELIKVSKVKNNLTFSTGDLIKLNDRIRESLNEIYLMANVVVSELLSDIRDQIGCLYKLAELVSMLDMLVSFA-HICTL-SDYVRPEFTD-----TLAIKQGRHPILDKILHETPVPNNMYAAEGTNFLIITGPNMSGKSTYLKQIALLQVMAQIGCYVPAEYASFRLADQIFSRIGSDDDIETNSSTFMLEMKEINYIIQNASDKSLIIVDELGRGTSSEEGVGICYAVCEHLLG-IKAFTFFATHFLELTTMDELYPNVENLHFEIQS 767
BLAST of Msh2 vs. Ensembl Nematostella
Match: EDO48759 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RIQ7]) HSP 1 Score: 172.555 bits (436), Expect = 3.106e-44 Identity = 162/629 (25.76%), Postives = 285/629 (45.31%), Query Frame = 1
Query: 742 LVDTEGAETIGCLGSVITYLD-------LANDESFFNFFDVQTFKLDNYMRVGEQCSRALNIL---------PSPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNR------------LDIVESL------INDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFE-AVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSR----KDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFDE-SRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEH-IATELKAFSAF-ATHFHELTDLSKIHCNVNNLHV-TAQTI--GNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIK 2493
LV + + G+++ YL+ L + + D+ F +D+ + V + AL I S ++ SL+G+LN R+A G RLL W +P D+ ++ R +D++ SL + + +R + + L+ + + RI R++ + ++ D LY + A + +L P + I +++ ++ + D N + + DF+ + + + F VK VD +L E + + L M + + +KL S + LGY + V R K+E + L + + ++ + T +E+ + HR + L + A+LD L SLA V Y P++ + + HPL E+ + ++ ND + +E S I+TGPN GKS Y++ +GLI +A IGSFVP + A I + DR+ TRI + G+STFM ++ ++ +++AT KSL++IDE G+GT+T DG L + H +A+ K +THFH L K+ ++ L T + I G EL+F+Y + +G A SY +A +G+P+ +K
Sbjct: 183 LVPFDNVNMVRAAGALLKYLEKKRFGQELEDPDVHVPILDLVVFSIDDMVIVDDNTYSALQIFQKESHPSVYKSGTSSKEGLSLFGVLNRTRSALGSRLLRMWFLRPTRDILVLTERQKAITFFTTPRNIDLIASLQDCLKNVKNVSVRLYITKRELK-VKSVPRILVRMKTAQASITDWQALYKTVYNAMYIADLCR--TIPSEIAIAKKITVLVTQ---DLHNIASLINTIIDFDDSTEQNRFVVKPGVDPALDERKRTYNGLPDFMTKVARKELNKLN-PSIVECNVIYLPQLGYLLAVPRTTKMKEEKDFEMDGLDFVF--LSNNMVYYKSASTRDHETAIMHRLQSTIL-------------ERTKVLLDVMECTAELDCLISLA--VSARENNYVCPEITSKS---ILHITGGMHPLQELCVS-QFVPNDTAINEDSGRVVILTGPNASGKSVYLKQVGLIVFLAHIGSFVPAESAIIGVTDRLFTRIHTRETVSVGLSTFMIDLNQVASAIQSATDKSLVLIDEFGKGTATVDGLSLLCATLRHWLASSSKCPKTLVSTHFHSLIR-QKLLPDIPILRFQTTEVIQDGKELVFLYHLVDGHAKTSYASHIAALAGMPEHLVK 782
BLAST of Msh2 vs. Ensembl Medaka
Match: msh2 (mutS homolog 2 [Source:NCBI gene;Acc:101167993]) HSP 1 Score: 617.076 bits (1590), Expect = 0.000e+0 Identity = 340/862 (39.44%), Postives = 524/862 (60.79%), Query Frame = 1
Query: 1 N*NMDELT-NSFSLFWNSLGDKPNSTIRFFDRQDYYTVHFEDAEMLARSYYKSMEILKYFRRDSVSSPYINISKSNSDGVFKYLLIANQYKVEVYSNN----KSHDSWNLDFVATPGNLEKYQDILFKDVELVSS-NSLLGLNIKRINDDYRIFLGFCDLDNGIFMIGGFEESFTGYEQLANLSSALFQLNCRECLIPN-DTRPELLAVKNAVQSAGLLVTEVKKSFFSSENVMNSILKLICKTKLNNENTVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNILP-SPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFDES-RTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYENLMEWDSNHSEK 2559
N +MD + + F F S+ +KP++T R FDR +YYTVH +DA A+ +K+ ++KY S + +SK N + K LL+ QY+VEVY N+ K HD W +++ A+PGNL +++DILF ++ + D R+ +G +D +G E F E +NL S L Q++ +ECL+ D+ + ++ VQ G+LV++ K++ FSS+++ + +L+ + K L + + + CL +V+ +LDL +DES FN F + + L YMR+ ALN+ SP+D+ SL GLLN CRT G+RL+ QWIKQPLMD I RLD+VES + D++LR + L R PDL R+ ++ R+ LQD Y++Y A+ Q ++ +++G Y+ ++Q+ +S + ++ D + +M + D + +HEF VK D L E M L+ M+ + + +LG+E+ K +K ES+ LG+Y+RV+ K+E LRN + ++ K+GV+F +++++ +NE Y +++ +YEE + +I++EI+ I + YV L LS +IA+LD + SLA AP Y RP+++D+ R ++ RHP +E + ++I ND+SF + R+F IITGPNMGGKSTYIR +G+I++MAQIG FVPC+ AE+S+ D I+ R+GAGD Q+ GVSTFM+EML+ + IL++AT SLIIIDELGRGTST+DGFGLAW+ISEHIA+++ F FATHFHELT L+ +V+NLHVTA T N L +Y+V+ G +S+GI VA+ + P + +A+ K E E E N E+
Sbjct: 8 NFSMDSVAEHGFLSFIFSMPEKPDTTFRIFDRNEYYTVHGKDAIFAAKEVFKTNGVIKYLGAGSRKLESVILSKLNFEAFVKDLLLVRQYRVEVYRNHSKSSKEHD-WRIEYKASPGNLTQFEDILFGGATGAEGCAGVVAVRFATAADGQRV-VGVGYVDAAQRKMGVCE--FPDNEIFSNLESLLVQISPKECLLAQGDSSTDGNKLREVVQRGGMLVSDRKRADFSSKDITQDLNRLL-RVKKGEAMASSTLSELDKQVAMSCLAAVVRFLDLLSDESNFNSFSLASLDLGQYMRLDNAAVGALNLFQGSPDDISGAHSLAGLLNKCRTPQGQRLVNQWIKQPLMDKTKIEERLDLVESFVCDSELRQTCQGDLLHRFPDLHRLAKKFHRHSATLQDCYRVYQAVSQIPGLIAAFEKYSGSYQVLLQAVFTSPLTDLQTDFTKYQEMVETTLDMNQIDHHEFLVKASFDPVLTELREKMDDLEESMQAVLNSAARELGLEAGKTVKLESNAMLGFYLRVTCKEEKGLRNNKKFTTLDVQKNGVRFTNSKLSSLNEEYTRNKEEYEEAQNAIVKEIINIASGYVDPLQTLSDVIAQLDAVVSLALASVSAPVPYVRPRILDE-GCRRLELVQARHPCMETDADTAFIPNDVSFVQGERSFYIITGPNMGGKSTYIRQVGVIALMAQIGCFVPCEKAELSVTDSILARVGAGDSQVKGVSTFMSEMLETAAILRSATENSLIIIDELGRGTSTYDGFGLAWAISEHIASKISCFCLFATHFHELTALASQQPSVHNLHVTALTTHNTLTMLYRVKAGVCDQSFGIHVAELACFPPAVLAVAREKAEELEEFQEPMGNQQEE 863
BLAST of Msh2 vs. Ensembl Medaka
Match: msh3 (mutS homolog 3 [Source:NCBI gene;Acc:101156254]) HSP 1 Score: 239.195 bits (609), Expect = 2.074e-65 Identity = 213/738 (28.86%), Postives = 349/738 (47.29%), Query Frame = 1
Query: 490 FEESFTGYEQLANLSSALFQLNCRECLIPNDTRPE----LLAVKN-AVQSAGLLVTEVKKSF-FSSENVMNSILKLICKTKLNNENTVLKLVDTEGAETIGCLGSVITYLDLAN------DESFFNFFDVQTFKLDNYMRVGEQCSRALNILPSPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVI-QEILKDTENFIQMFTSFFDF--EAVKNHEFKVKCDVDES----LKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQM------TLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSII---AKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEM----QNNMSYIANDISFDESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCN----------VNNLHVTAQT----IGNELI-FMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYENLMEWDSNHSEKL 2562
F + F + L S + ++N E L+P+D E LL+V N + Q+ E + S F + +N++ + C+++ + ++ ++ E + I CLG +I YL N ES F ++ M + R L IL + D SL+ +L+ RT G RL+ +W+ QPL D+ I+ R D V+ ++ + + L R+PDL+R + K + Q+ Y + S L+ L + I+S+ SV+ + +L DT + + +F + E K + D S L+E + + S+++ E K ++ Y+ VS ++ + S S + + D VK ST+ L+ E Y + ++ E+ E +++ H + I A +D L SLA + G Y RPKV +D +++ RHP +++ QN D+ D RT IITGPNMGGKS+YIR + LI +MAQIGSFVP A + + D I TR+GA D G STFM E+ + S I+ AT +SL+I+DELGRGTST DG +A++ E+ +K+F+ F TH+ L +L +++ + +N H+++ T + E I F+Y + EG A +SYG+ VAK + +PD + A K E E+ +E ++L
Sbjct: 364 FLDCFPDGSSRSELESRILKINPVEILVPSDLSEETCRLLLSVTNGSFQADDRARVERRDSAQFEYTSAINTVTQFYCRSQQEDSRSLWRVASFE-SPVICCLGPLIQYLQEFNLERVLRSESSFQRLSCES----EAMILNAATLRNLEILNNQTDRGVRGSLFWVLDHSRTPFGRRLMRKWVSQPLTDLQRISERQDAVQEIMESDSPILDSVKSLLPRLPDLERGICSIYHKKSSTQEFYLI-------SSHLSRLGLQLQSWIPAIRSQTRSVLLRSVLLDTPDLLAPAHTFLNVLNEKAARSGNKTELFSDLSGFPVLQERTKQIHFVLSEIQ------------EHLKDIRMVLKAPTLNYITVSGQEFLIEVKNSLSSTVPS--DWVKISSTKAVGRYHSPLLVERYKKLQQLREQLLLDCQREWTDFLDQFGEHYHTMKRAISHLATIDCLFSLAEV--AQQGGYCRPKVCEDQPQ--IMIRDGRHPAIDLLMGEQNQFVPNHTDLQGDGKRTM-IITGPNMGGKSSYIRQVALICIMAQIGSFVPASEACLGLLDGIYTRMGASDNIYKGRSTFMEELTEASEIISRATERSLVILDELGRGTSTHDGIAIAYATLEYFIRHVKSFTLFVTHYPPLCELERMYPDHVSNFHMAFLLNETHISSDTKDGDVQPEFITFLYNLTEGAAGQSYGLNVAKLADVPDPILCTAARKAQELESAVEARRRSKKRL 1070
BLAST of Msh2 vs. Ensembl Medaka
Match: msh4 (mutS homolog 4 [Source:NCBI gene;Acc:101160275]) HSP 1 Score: 206.453 bits (524), Expect = 4.308e-55 Identity = 171/584 (29.28%), Postives = 285/584 (48.80%), Query Frame = 1
Query: 922 DLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKL------RGCLYEENLRRIPDLQRITRR--LQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFIS---IIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFDESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQ------TIGNELIFMYKVEEGPA-VRSYGIEVAKASGLPDESIKLAKLKLSEY-ENLMEWDSNHSEK---------LAATRNALME 2589
D R +L G+LN +T G R L I +PL++V+ IN RLD V+ L+ D +L C + + R + L +I ++ +Q + + + +L L + + N P + +LSS+ I DT + K + V+ +++E L + + + +++ +K G+ ++ S S G+++++ + D +VL S + K+ F + + MN + R+ +I +++ + ++ L++LS ++ LD+L SLA C Y RP+ D +K RHP++E +N+ E F IITGPNM GKSTY++ + L +MAQIGSFVP + A + +I TRIG D T S+FM EM +IS+I+ A+ +SLIIIDELGRGTS +G G+ S+ E + LKAF+ FATHF EL L ++ NV N H+ Q T +++ Y ++ G + R YG+ A+ + LP I+ A+ S+ + LM + +H ++ L A RN+ ++
Sbjct: 245 DHRSEHTLLGVLNHTKTPGGARRLRSNILEPLVNVDTINMRLDAVQELLQDEELFFGLKNAICHFLDVDRLLSVLVQIPKQETVQAAEAKITHVIQLKHTLDLVPQLRTVFKNCNTP----LLKQLSSIKTVINPDT----MYLKGSLNMRTQKC--YAVRPNINEFLDIARRAYTEIVDDIAVLVNQMGEKYGLP----MRTSFSTSRGFFIQL-KLDGSVLPRGSLPPECIKVTKHKNNYCFTTADLMKMNGRCDEALREIFHMSYVVICQLLSTIHGHIHCLYKLSDAVSMLDMLLSLAN-ACTI-SDYVRPEFTD-----TLAIKQGRHPILERMARQQPTSNNAYISEGSNFVIITGPNMSGKSTYLKQVALCQIMAQIGSFVPAEYASFRLAGQIFTRIGVDDDFETNSSSFMLEMKEISYIIHNASDRSLIIIDELGRGTSAEEGVGICHSVCEFLLG-LKAFTLFATHFLELCQLESLYPNVENQHMEVQHTRSGDTGVEHVVYTYLLKRGCSEERLYGLRAAEMTALPPNIIQEARTIASKVSQQLMVYPKSHRQRALYRLATRLLQAARNSRLD 805
BLAST of Msh2 vs. Ensembl Medaka
Match: msh4 (mutS homolog 4 [Source:NCBI gene;Acc:101160275]) HSP 1 Score: 201.06 bits (510), Expect = 3.400e-53 Identity = 162/549 (29.51%), Postives = 268/549 (48.82%), Query Frame = 1
Query: 922 DLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKL------RGCLYEENLRRIPDLQRITRR--LQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGP----YKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFIS---IIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFDESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQ------TIGNELIFMYKVEEGPA-VRSYGIEVAKASGLPDESIKLAK 2502
D R +L G+LN +T G R L I +PL++V+ IN RLD V+ L+ D +L C + + R + L +I ++ +Q + + + +L L + + N P Y ++ +I E +K N M+ + V+ +++E L + + + +++ +K G+ ++ S S G+++++ + D +VL S + K+ F + + MN + R+ +I +++ + ++ L++LS ++ LD+L SLA C Y RP+ D +K RHP++E +N+ E F IITGPNM GKSTY++ + L +MAQIGSFVP + A + +I TRIG D T S+FM EM +IS+I+ A+ +SLIIIDELGRGTS +G G+ S+ E + LKAF+ FATHF EL L ++ NV N H+ Q T +++ Y ++ G + R YG+ A+ + LP I+ A+
Sbjct: 291 DHRSEHTLLGVLNHTKTPGGARRLRSNILEPLVNVDTINMRLDAVQELLQDEELFFGLKNAICHFLDVDRLLSVLVQIPKQETVQAAEAKITHVIQLKHTLDLVPQLRTVFKNCNTPLLKAYSSTLEDNRFDMILEQIKTVINPDTMYLKG-SLNMRTQKCYAVRPNINEFLDIARRAYTEIVDDIAVLVNQMGEKYGLP----MRTSFSTSRGFFIQL-KLDGSVLPRGSLPPECIKVTKHKNNYCFTTADLMKMNGRCDEALREIFHMSYVVICQLLSTIHGHIHCLYKLSDAVSMLDMLLSLAN-ACTI-SDYVRPEFTD-----TLAIKQGRHPILERMARQQPTSNNAYISEGSNFVIITGPNMSGKSTYLKQVALCQIMAQIGSFVPAEYASFRLAGQIFTRIGVDDDFETNSSSFMLEMKEISYIIHNASDRSLIIIDELGRGTSAEEGVGICHSVCEFLLG-LKAFTLFATHFLELCQLESLYPNVENQHMEVQHTRSGDTGVEHVVYTYLLKRGCSEERLYGLRAAEMTALPPNIIQEAR 825
BLAST of Msh2 vs. Ensembl Medaka
Match: msh3 (mutS homolog 3 [Source:NCBI gene;Acc:101156254]) HSP 1 Score: 180.259 bits (456), Expect = 4.425e-46 Identity = 102/257 (39.69%), Postives = 150/257 (58.37%), Query Frame = 1
Query: 1822 YARPKVVDDCKTRVFKVKNCRHPLVEM----QNNMSYIANDISFDESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCN----------VNNLHVTAQT----IGNELI-FMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYENLME 2535
+ PKV +D +++ RHP +++ QN D+ D RT IITGPNMGGKS+YIR + LI +MAQIGSFVP A + + D I TR+GA D G STFM E+ + S I+ AT +SL+I+DELGRGTST DG +A++ E+ +K+F+ F TH+ L +L +++ + +N H+++ T + E I F+Y + EG A +SYG+ VAK + +PD + A K E E+ +E
Sbjct: 772 FLEPKVCEDQPQ--IMIRDGRHPAIDLLMGEQNQFVPNHTDLQGDGKRTM-IITGPNMGGKSSYIRQVALICIMAQIGSFVPASEACLGLLDGIYTRMGASDNIYKGRSTFMEELTEASEIISRATERSLVILDELGRGTSTHDGIAIAYATLEYFIRHVKSFTLFVTHYPPLCELERMYPDHVSNFHMAFLLNETHISSDTKDGDVQPEFITFLYNLTEGAAGQSYGLNVAKLADVPDPILCTAARKAQELESAVE 1025 HSP 2 Score: 76.6406 bits (187), Expect = 8.965e-14 Identity = 75/298 (25.17%), Postives = 135/298 (45.30%), Query Frame = 1
Query: 490 FEESFTGYEQLANLSSALFQLNCRECLIPNDTRPE----LLAVKN-AVQSAGLLVTEVKKSF-FSSENVMNSILKLICKTKLNNENTVLKLVDTEGAETIGCLGSVITYLDLAN------DESFFNFFDVQTFKLDNYMRVGEQCSRALNILPSPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSV-IQEILKDTENFIQMFTSFFD 1344
F + F + L S + ++N E L+P+D E LL+V N + Q+ E + S F + +N++ + C+++ + ++ ++ E + I CLG +I YL N ES F ++ M + R L IL + D SL+ +L+ RT G RL+ +W+ QPL D+ I+ R D V+ ++ + + L R+PDL+R + K + Q+ Y + S L+ L + I+S+ SV ++ +L DT + + +F +
Sbjct: 364 FLDCFPDGSSRSELESRILKINPVEILVPSDLSEETCRLLLSVTNGSFQADDRARVERRDSAQFEYTSAINTVTQFYCRSQQEDSRSLWRVASFE-SPVICCLGPLIQYLQEFNLERVLRSESSFQRLSCES----EAMILNAATLRNLEILNNQTDRGVRGSLFWVLDHSRTPFGRRLMRKWVSQPLTDLQRISERQDAVQEIMESDSPILDSVKSLLPRLPDLERGICSIYHKKSSTQEFYLI-------SSHLSRLGLQLQSWIPAIRSQTRSVLLRSVLLDTPDLLAPAHTFLN 649
BLAST of Msh2 vs. Planmine SMEST
Match: SMESG000016751.1 (SMESG000016751.1) HSP 1 Score: 1790.01 bits (4635), Expect = 0.000e+0 Identity = 884/884 (100.00%), Postives = 884/884 (100.00%), Query Frame = 1
Query: 10 MDELTNSFSLFWNSLGDKPNSTIRFFDRQDYYTVHFEDAEMLARSYYKSMEILKYFRRDSVSSPYINISKSNSDGVFKYLLIANQYKVEVYSNNKSHDSWNLDFVATPGNLEKYQDILFKDVELVSSNSLLGLNIKRINDDYRIFLGFCDLDNGIFMIGGFEESFTGYEQLANLSSALFQLNCRECLIPNDTRPELLAVKNAVQSAGLLVTEVKKSFFSSENVMNSILKLICKTKLNNENTVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNILPSPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFDESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYENLMEWDSNHSEKLAATRNALMEFCLKDLVKDSIDFPVFVKMLRDKL 2661
MDELTNSFSLFWNSLGDKPNSTIRFFDRQDYYTVHFEDAEMLARSYYKSMEILKYFRRDSVSSPYINISKSNSDGVFKYLLIANQYKVEVYSNNKSHDSWNLDFVATPGNLEKYQDILFKDVELVSSNSLLGLNIKRINDDYRIFLGFCDLDNGIFMIGGFEESFTGYEQLANLSSALFQLNCRECLIPNDTRPELLAVKNAVQSAGLLVTEVKKSFFSSENVMNSILKLICKTKLNNENTVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNILPSPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHRRDYEEYERSIIEEIMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFDESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYENLMEWDSNHSEKLAATRNALMEFCLKDLVKDSIDFPVFVKMLRDKL
Sbjct: 1 MDELTNSFSLFWNSLGDKPNSTIRFFDRQDYYTVHFEDAEMLARSYYKSMEILKYFRRDSVSSPYINISKSNSDGVFKYLLIANQYKVEVYSNNKSHDSWNLDFVATPGNLEKYQDILFKDVELVSSNSLLGLNIKRINDDYRIFLGFCDLDNGIFMIGGFEESFTGYEQLANLSSALFQLNCRECLIPNDTRPELLAVKNAVQSAGLLVTEVKKSFFSSENVMNSILKLICKTKLNNENTVLKLVDTEGAETIGCLGSVITYLDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNILPSPNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLINDNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMFTSFFDFEAVKNHEFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHRRDYEEYERSIIEEIMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFDESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLAKLKLSEYENLMEWDSNHSEKLAATRNALMEFCLKDLVKDSIDFPVFVKMLRDKL 884
BLAST of Msh2 vs. Planmine SMEST
Match: SMESG000019325.1 (SMESG000019325.1) HSP 1 Score: 163.31 bits (412), Expect = 1.884e-44 Identity = 100/304 (32.89%), Postives = 165/304 (54.28%), Query Frame = 1
Query: 1822 YARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFDESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQTIG------NELIFMYKVEEGPAVR-SYGIEVAKASGLPD----ESIKLAKLKLSEYENLMEWDSNHSEKLAATR-----NALMEFCLKDLVKDSIDFPVFVKMLRDKL*LSIDRAN 2685
Y RP+ D +KNCR+PL++ +N I+N + F I+TG NM GKS Y+R I L+ +M QIG F+P + A + D + TRIG D + STF EM ++S+I+ T T SL++IDELGRGTS +G G+ ++I EH+ + KAF ATHF EL+ L ++ NV N++ + + N L+F YK G + +++AK S LP E+ K+ E ++E + ++ +A+ +A +E+ K++ D+ + +K L+++ ++ ++ N
Sbjct: 4 YIRPEFTD-----TLAIKNCRNPLLDRLSNKETISNHVYAANLSNFTIVTGANMSGKSMYLRQIALVQIMGQIGCFIPAEYASFRLSDHLFTRIGVDDDIQSNSSTFTIEMREMSYIINTITDNSLVLIDELGRGTSFDEGLGICFAICEHLL-QTKAFIFIATHFRELSKLEILYPNVQNVNFEVKNLSESDGDENHLLFTYKCVRGVCPDFTNAMKLAKLSNLPKQLLFEAEKIYGRLGDSNELIIEENEKNTNSIASDYEICKLSAKIEYLAKNVTVDTPEVNFCLKSLQNQCRVTFEKLN 301
BLAST of Msh2 vs. Planmine SMEST
Match: SMESG000073017.1 (SMESG000073017.1) HSP 1 Score: 155.606 bits (392), Expect = 2.158e-38 Identity = 166/617 (26.90%), Postives = 275/617 (44.57%), Query Frame = 1
Query: 922 DLRKHDSLYGL-------LNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLIN-DNKLRGCLYEENLRRIPDLQRITRR-----LQRNKGNLQD----IYK-LYVALRQASDMLNLLNEHNGPYKC--------IIQSELSSVIQEIL-----------KDTENFIQMFTSFFDFEAVKNH-----EFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXM-KITNKYVGSLHQLSSII---AKLDVLCSLATMVCGAPG-TYARPKV--VDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISF-----DESRTFQ----IITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEI-SIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQT--------------IGNEL-----IFMYKVEEGPAVRSYGIEVAKASGLPDESI--KLAKLKLSEYENLM 2532
DL K+ SL G+ L+ TA G RLL+QWI PL D + I R ++ LI D L + NL+ PDL+++ + L ++ + D +Y+ L + R+ +D +N L + K + Q+ S ++++I+ D I F + FD E K + E + D DES+ + L +E + ++ + T + +F+ +V I + + G K + +T+ E L+ + E+ +++ IM KI K+ Q + +I A+ D L SL + G G RP++ ++ + R P + +I+N I + +R ++TGPNMGGKST +R LI +++Q+G +VP +G I + DR+ TR GA D +G ST EM + + IL + S ++IDELGRGT+T+DG LA+SI + IA + F+THFH+L + +I N+ H+ + N L F+YK+ G +SYG A+ + +P++ I L K K+ E E L+
Sbjct: 575 DLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNI--KNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIINSNINFFGTGKNRFQLEIPESKCSKVPS-----------TYIASSQRKGFKRY---LTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPCKAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEDDNDDDVGNNECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEETLI 1175
BLAST of Msh2 vs. Planmine SMEST
Match: SMESG000006277.1 (SMESG000006277.1) HSP 1 Score: 121.324 bits (303), Expect = 4.398e-28 Identity = 155/620 (25.00%), Postives = 264/620 (42.58%), Query Frame = 1
Query: 799 LDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNIL-----PS------PNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLIN-DNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMF-TSFFDFEAV-KNHEFKVKCDVDESLKECENSMITLKSQMET--------------------------------ESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDI-SFDESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEH-IATELKAFSAF-ATHFHEL----TDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLA 2499
++L ++ S DVQ + M + E +AL+I PS D ++ S++ LLN C + +L W+++PL D+++I RLD V+ N N+ + L+ + ++++I R++ + L D L ++ + + + P E+ I+ D I + T D E + K F VK VD L E ++ L + E++ K+ I + L F +N++ Y ++K +K F I+ +KD ++ M + ES L+ Y L ++ +LD L SLA GT RP + K++N RHPL E+ +N +I N S D II+G N GKS Y++ IG++ V+AQIGSFVP ++ + ++TR+ + + L+G+STFM ++ IS K A + S I+IDE G+G G L + +A + + F THFH L DL K+ N +V ++LI++Y++ +G S+ I+ A+ + D ++ A
Sbjct: 26 VELESEISKIPVLDVQIYTTAKTMFIDENSLKALDIFNKVSHPSGFKQGVKKDTKEGLSIFHLLNNCHSKMASDMLHSWLRRPLTDISMIQKRLDCVDFFQNSQNQDVLQILLRKLKGVGNIKQILLRMKNSTALLPDWNVLIQSIAGLISIFEIFSAIKEPL------EIKQKIEAKFTDKLYLIASWITKIIDTEGIEKQKRFVVKEGVDPYLDEKKSKYYHLPDLLSALAEEELKGFNNDIQICGIVYLPQVGYLLTIPIENNENEQKINIPGMEYL-FSMNNAVYYKNYTTKK-----LDKEFGDILYEIKD---LETSIMHCLQESILE----------------------YTHMLLNCLDLVLELDCLLSLAIAARQIGGT--RPLFETSGE---IKIENGRHPLQEVFSN-PFIPNSTYSNDWDGKLTIISGANGSGKSVYLKQIGILIVLAQIGSFVPATKMSLTPQNALLTRLKSLESSLSGLSTFMVDLNQISLCCKKANAHSTILIDEFGKGAEMKSGISLIVAFLRFMVAKKSECPHIFVVTHFHRLFSLIQDLPKVQ--FKNFNVIEDK-HSQLIYLYQLVDGHIECSHAIQAARLVNVSDNILQRA 599
BLAST of Msh2 vs. Planmine SMEST
Match: SMESG000006277.1 (SMESG000006277.1) HSP 1 Score: 119.398 bits (298), Expect = 1.614e-27 Identity = 151/592 (25.51%), Postives = 263/592 (44.43%), Query Frame = 1
Query: 799 LDLANDESFFNFFDVQTFKLDNYMRVGEQCSRALNIL-----PS------PNDLRKHDSLYGLLNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLIN-DNKLRGCLYEENLRRIPDLQRITRRLQRNKGNLQDIYKLYVALRQASDMLNLLNEHNGPYKCIIQSELSSVIQEILKDTENFIQMF-TSFFDFEAV-KNHEFKVKCDVDESLKECENSMITLKSQM----ETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHXXXXXXXXXXXXXXXMKITNKYVGSLHQLSSIIAKLDVLCSLATMVCGAPGTYARPKVVDDCKTRVFKVKNCRHPLVEMQNNMSYIANDI-SFDESRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEISIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEH-IATELKAFSAF-ATHFHEL----TDLSKIHCNVNNLHVTAQTIGNELIFMYKVEEGPAVRSYGIEVAKASGLPDESIKLA 2499
++L ++ S DVQ + M + E +AL+I PS D ++ S++ LLN C + +L W+++PL D+++I RLD V+ N N+ + L+ + ++++I R++ + L D L ++ + + + P E+ I+ D I + T D E + K F VK VD L E ++ L + E E ++ + I L +GY + + ++ N+ I+I G+++ ++ N Y ++ + I +Y L ++ +LD L SLA GT RP + K++N RHPL E+ +N +I N S D II+G N GKS Y++ IG++ V+AQIGSFVP ++ + ++TR+ + + L+G+STFM ++ IS K A + S I+IDE G+G G L + +A + + F THFH L DL K+ N +V ++LI++Y++ +G S+ I+ A+ + D ++ A
Sbjct: 26 VELESEISKIPVLDVQIYTTAKTMFIDENSLKALDIFNKVSHPSGFKQGVKKDTKEGLSIFHLLNNCHSKMASDMLHSWLRRPLTDISMIQKRLDCVDFFQNSQNQDVLQILLRKLKGVGNIKQILLRMKNSTALLPDWNVLIQSIAGLISIFEIFSAIKEPL------EIKQKIEAKFTDKLYLIASWITKIIDTEGIEKQKRFVVKEGVDPYLDEKKSKYYHLPDLLSALAEEELKGFNNDIQICGIVYLP-----QVGYLLTIPIENN---ENEQKINI-----PGMEY---LFSMNNAVYYKNYTTKNLETSIMHCLQESIL-EYTHMLLNCLDLVLELDCLLSLAIAARQIGGT--RPLFETSGE---IKIENGRHPLQEVFSN-PFIPNSTYSNDWDGKLTIISGANGSGKSVYLKQIGILIVLAQIGSFVPATKMSLTPQNALLTRLKSLESSLSGLSTFMVDLNQISLCCKKANAHSTILIDEFGKGAEMKSGISLIVAFLRFMVAKKSECPHIFVVTHFHRLFSLIQDLPKVQ--FKNFNVIEDK-HSQLIYLYQLVDGHIECSHAIQAARLVNVSDNILQRA 585 The following BLAST results are available for this feature:
BLAST of Msh2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Msh2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Msh2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Msh2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Msh2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Msh2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Msh2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Msh2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Msh2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Msh2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 3
BLAST of Msh2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Msh2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Msh2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Msh2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Cross References
External references for this transcript
Sequences
The following sequences are available for this feature:
transcript sequence >SMED30031773 ID=SMED30031773|Name=Msh2|organism=Schmidtea mediterranea sexual|type=transcript|length=2701bpback to top protein sequence of SMED30031773-orf-1 >SMED30031773-orf-1 ID=SMED30031773-orf-1|Name=SMED30031773-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=885bp MDELTNSFSLFWNSLGDKPNSTIRFFDRQDYYTVHFEDAEMLARSYYKSMback to top Aliases
The feature 'Msh2' has the following synonyms
Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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