Ras guanyl-releasing protein 3
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30031682 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 12
Homology
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Human
Match: RASGRP3 (RAS guanyl releasing protein 3 [Source:HGNC Symbol;Acc:HGNC:14545]) HSP 1 Score: 402.519 bits (1033), Expect = 4.453e-128 Identity = 231/573 (40.31%), Postives = 336/573 (58.64%), Query Frame = 2
Query: 350 RAATIDKLVEELLIHIEQSCESLDDISD-DNLVFPKIFFLVHNWFSTSESIGRKL---YNNADIKHKSDSSFEDDRILRSNRKFKIGGVTLAFCLWIEFYPNDFMGSESCMPILTKFIESLQEMGREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSPVA----NKSILFGDFVSGVKP-PTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKAN---HNALKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECR 2032
+AAT+D+L+ + E DD + DN P+I L+H W+ +S + KL Y NA + S +F++ + WI +P +F + + +F E ++G E ++ ++ S SYD R ++ R V S + C L+F+ + P++LAE LT +E K+FRRI+ D + Y + + N PTLERS+ +FNG+S+WVQ M+L+K P +RA+V+ KF+ +A+ LL L+NFN+ AV+GG++HS+ISR+ T LS K E T+++SS+ NY NYR+ + GF IP++ VHLKDLI H PD N +N K Q + TL ++ Q +E N+DL N L LSLDL +TE+DIY+LSL EP++S P + NK ++ ++ GV P P V+ +H+ +VE+VF+ YD+D DG IS E+FE +A NFPF+DSF VLD D+DG+ISK EM YFL+A H + F H F E TY KPTFC HC G LWG+IKQG++C+DCG N HK CK+ +V+ CR
Sbjct: 8 KAATLDELLCTCI-------EMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGE--------------SCNEFRLK-ICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSIPSYDWMRRVTQRKKV-----------SKKGKAC-LLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPD-WTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACR 545
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Human
Match: RASGRP3 (RAS guanyl releasing protein 3 [Source:HGNC Symbol;Acc:HGNC:14545]) HSP 1 Score: 402.519 bits (1033), Expect = 4.453e-128 Identity = 231/573 (40.31%), Postives = 336/573 (58.64%), Query Frame = 2
Query: 350 RAATIDKLVEELLIHIEQSCESLDDISD-DNLVFPKIFFLVHNWFSTSESIGRKL---YNNADIKHKSDSSFEDDRILRSNRKFKIGGVTLAFCLWIEFYPNDFMGSESCMPILTKFIESLQEMGREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSPVA----NKSILFGDFVSGVKP-PTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKAN---HNALKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECR 2032
+AAT+D+L+ + E DD + DN P+I L+H W+ +S + KL Y NA + S +F++ + WI +P +F + + +F E ++G E ++ ++ S SYD R ++ R V S + C L+F+ + P++LAE LT +E K+FRRI+ D + Y + + N PTLERS+ +FNG+S+WVQ M+L+K P +RA+V+ KF+ +A+ LL L+NFN+ AV+GG++HS+ISR+ T LS K E T+++SS+ NY NYR+ + GF IP++ VHLKDLI H PD N +N K Q + TL ++ Q +E N+DL N L LSLDL +TE+DIY+LSL EP++S P + NK ++ ++ GV P P V+ +H+ +VE+VF+ YD+D DG IS E+FE +A NFPF+DSF VLD D+DG+ISK EM YFL+A H + F H F E TY KPTFC HC G LWG+IKQG++C+DCG N HK CK+ +V+ CR
Sbjct: 8 KAATLDELLCTCI-------EMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGE--------------SCNEFRLK-ICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSIPSYDWMRRVTQRKKV-----------SKKGKAC-LLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPD-WTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACR 545
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Human
Match: RASGRP3 (RAS guanyl releasing protein 3 [Source:HGNC Symbol;Acc:HGNC:14545]) HSP 1 Score: 400.208 bits (1027), Expect = 2.622e-127 Identity = 232/573 (40.49%), Postives = 337/573 (58.81%), Query Frame = 2
Query: 350 RAATIDKLVEELLIHIEQSCESLDDISD-DNLVFPKIFFLVHNWFSTSESIGRKL---YNNADIKHKSDSSFEDDRILRSNRKFKIGGVTLAFCLWIEFYPNDFMGSESCMPILTKFIESLQEMGREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSPVA----NKSILFGDFVSGVKP-PTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKAN---HNALKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECR 2032
+AAT+D+L+ + E DD + DN P+I L+H W+ +S + KL Y NA + S +F++ + WI +P +F + + +F E ++G E ++ ++ S SYD R ++ R V S + C L+F+ + P++LAE LT +E K+FRRI+ D + Y + + N PTLERS+ +FNG+S+WVQ M+L+K P +RA+V+ KF+ +A+ LL L+NFN+ AV+GG++HS+ISR+ T LS K E T+++SS+ NY NYR+ + GF IP++ VHLKDLI H PD N +N K Q + TL ++ Q +E N+DL N L LSLDL +TE+DIY+LSL EP++S SP + NK ++ ++ GV P P V+ +H+ +VE+VF+ YD+D DG IS E+FE +A NFPF+DSF VLD D+DG+ISK EM YFL+A H + F H F E TY KPTFC HC G LWG+IKQG++C+DCG N HK CK+ +V+ CR
Sbjct: 8 KAATLDELLCTCI-------EMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGE--------------SCNEFRLK-ICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSIPSYDWMRRVTQRKKV-----------SKKGKAC-LLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPD-WTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNS-KSPTSPTTPNKPVVPLEWALGVMPKPDPTVINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACR 544
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Human
Match: RASGRP1 (RAS guanyl releasing protein 1 [Source:HGNC Symbol;Acc:HGNC:9878]) HSP 1 Score: 364.77 bits (935), Expect = 1.546e-112 Identity = 208/507 (41.03%), Postives = 305/507 (60.16%), Query Frame = 2
Query: 599 GVTLAFCLWIEFYPNDFMGSESCMPILTKFIESLQEM----GREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSPV-ANKSILFGDFVSGVKP-PTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKAN--HNALKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECRSRGHLYQHNRSSSQSTETNVS 2095
G+ L C ++ ++ +F LT +E QE+ G E ++ + ++ D SR L+ R +K +S SL+F+ + P +L+E LT +EFK+FRRI+ D + Y + + V+ PT+ERS+ + NG+SQWVQ M+L++ P RA+V KF+ +A+ L LQNFN+ AVIGG+ HS+ISR+ T + K+L E T+++SSS NY NYR+ E F IP++ VHLKDLI + A+PD+L + +N K + ++ Q +E N DL + L LSLDL YTE++IYELS AREP++ P+ +K + D+ SGV P P + +HV MV++VFK YD+D+DG IS EEFE +A +FPF SF V+D D++G+IS+ E+ YF++A+ ++ L F H F E TY KPTFC +C G LWG+IKQG+RC+DCG+N HK CK+ VV EC+ R ++ TE N S
Sbjct: 120 GLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELVKAKGEELHCRLIDTTQINARDWSRKLTQR----------IKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGK-VNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASGVSPKPDPKTISKHVQRMVDSVFKNYDHDQDGYISQEEFEKIAASFPF--SFCVMDKDREGLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKRA------KNPVAPTENNTS 607
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Human
Match: RASGRP1 (RAS guanyl releasing protein 1 [Source:HGNC Symbol;Acc:HGNC:9878]) HSP 1 Score: 364.77 bits (935), Expect = 1.629e-112 Identity = 208/507 (41.03%), Postives = 305/507 (60.16%), Query Frame = 2
Query: 599 GVTLAFCLWIEFYPNDFMGSESCMPILTKFIESLQEM----GREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSPV-ANKSILFGDFVSGVKP-PTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKAN--HNALKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECRSRGHLYQHNRSSSQSTETNVS 2095
G+ L C ++ ++ +F LT +E QE+ G E ++ + ++ D SR L+ R +K +S SL+F+ + P +L+E LT +EFK+FRRI+ D + Y + + V+ PT+ERS+ + NG+SQWVQ M+L++ P RA+V KF+ +A+ L LQNFN+ AVIGG+ HS+ISR+ T + K+L E T+++SSS NY NYR+ E F IP++ VHLKDLI + A+PD+L + +N K + ++ Q +E N DL + L LSLDL YTE++IYELS AREP++ P+ +K + D+ SGV P P + +HV MV++VFK YD+D+DG IS EEFE +A +FPF SF V+D D++G+IS+ E+ YF++A+ ++ L F H F E TY KPTFC +C G LWG+IKQG+RC+DCG+N HK CK+ VV EC+ R ++ TE N S
Sbjct: 120 GLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELVKAKGEELHCRLIDTTQINARDWSRKLTQR----------IKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGK-VNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASGVSPKPDPKTISKHVQRMVDSVFKNYDHDQDGYISQEEFEKIAASFPF--SFCVMDKDREGLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKRA------KNPVAPTENNTS 607
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Celegans
Match: rgef-1 (Rap Guanine nucleotide Exchange Factor homolog [Source:UniProtKB/TrEMBL;Acc:K8FDZ6]) HSP 1 Score: 348.206 bits (892), Expect = 2.745e-108 Identity = 202/537 (37.62%), Postives = 303/537 (56.42%), Query Frame = 2
Query: 446 FPKIFFLVHNWFSTSESIGRKLYNNADIKHKSDSSFEDDRILRSNRKFKIGGVTLAFCLWIEFYPNDFMGSESCMPILTKFIESLQEMGREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQ-LQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILD-QQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSPVANKSILFGDFVSGVK-PPTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKANHNA--LKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECRSRG 2041
F FL H W S S S+ N +++ R + V A WIE +P F P + + L+ + ED+ + L+ S S +SVR P++ SL F Q P ++ L+ I+++ RI+I +LK Y +R+ P LERS+ +FN LS WVQCMILNKT P ERA+++ KF+ +A++L + NFN+ +V+GGITHS+++R+ T LS +K L + T ++S+ +N+ YR+ L K F IP++ VHLKDL+ + + + I+ K + + L + L Q E N+DL NTL++SLD++Y ++DIYELSL REPK+ ++ ++ ++F ++ SGV P + +H++ MV+AVFK YD+D+DG IS EEF+L+A NFPFID+F +D D DG ISK E+K YF+ AN N L+ FKH F+E T+ PT C HC LLWG+++QG++C+DCG+ H CK V ECR +
Sbjct: 40 FVDALFLSHQWLSDSLSLITHFVN----------FYQETRNVEQRE-----AVCRAVSFWIEKFPMHF----DAQPQVCAQVVRLKTIA-EDINENIRNGLDVSALPSFAWLRAVSVRNPLAKQTAF--------SLSFVQASPSDISTSLSHIDYRVLSRISITELKQYVKDGHLRSCPMLERSISVFNNLSNWVQCMILNKTTPKERAEILVKFVHVAKHLRKINNFNTLMSVVGGITHSSVARLAKTYAVLSNDIKKELTQLTNLLSAQHNFCEYRKALGACNKKFRIPIIGVHLKDLVAINCSGAN-FEKTKCISSDKLVKLSKLLSNFLVFNQKGHNLPEMNMDLINTLKVSLDIRYNDDDIYELSLRREPKTFMNFE-PSRGLVFAEWASGVTVAPDNATVSKHISAMVDAVFKHYDHDRDGFISQEEFQLIAGNFPFIDAFVNIDVDMDGQISKDELKTYFMAANKNTKDLRRGFKHNFHETTFLTPTTCNHCNKLLWGILRQGFKCKDCGLAVHSCCKSNAVAECRRKS 546
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Celegans
Match: rgef-1 (Rap Guanine nucleotide Exchange Factor homolog [Source:UniProtKB/TrEMBL;Acc:K8FDZ6]) HSP 1 Score: 348.206 bits (892), Expect = 2.968e-108 Identity = 202/537 (37.62%), Postives = 303/537 (56.42%), Query Frame = 2
Query: 446 FPKIFFLVHNWFSTSESIGRKLYNNADIKHKSDSSFEDDRILRSNRKFKIGGVTLAFCLWIEFYPNDFMGSESCMPILTKFIESLQEMGREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQ-LQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILD-QQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSPVANKSILFGDFVSGVK-PPTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKANHNA--LKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECRSRG 2041
F FL H W S S S+ N +++ R + V A WIE +P F P + + L+ + ED+ + L+ S S +SVR P++ SL F Q P ++ L+ I+++ RI+I +LK Y +R+ P LERS+ +FN LS WVQCMILNKT P ERA+++ KF+ +A++L + NFN+ +V+GGITHS+++R+ T LS +K L + T ++S+ +N+ YR+ L K F IP++ VHLKDL+ + + + I+ K + + L + L Q E N+DL NTL++SLD++Y ++DIYELSL REPK+ ++ ++ ++F ++ SGV P + +H++ MV+AVFK YD+D+DG IS EEF+L+A NFPFID+F +D D DG ISK E+K YF+ AN N L+ FKH F+E T+ PT C HC LLWG+++QG++C+DCG+ H CK V ECR +
Sbjct: 40 FVDALFLSHQWLSDSLSLITHFVN----------FYQETRNVEQRE-----AVCRAVSFWIEKFPMHF----DAQPQVCAQVVRLKTIA-EDINENIRNGLDVSALPSFAWLRAVSVRNPLAKQTAF--------SLSFVQASPSDISTSLSHIDYRVLSRISITELKQYVKDGHLRSCPMLERSISVFNNLSNWVQCMILNKTTPKERAEILVKFVHVAKHLRKINNFNTLMSVVGGITHSSVARLAKTYAVLSNDIKKELTQLTNLLSAQHNFCEYRKALGACNKKFRIPIIGVHLKDLVAINCSGAN-FEKTKCISSDKLVKLSKLLSNFLVFNQKGHNLPEMNMDLINTLKVSLDIRYNDDDIYELSLRREPKTFMNFE-PSRGLVFAEWASGVTVAPDNATVSKHISAMVDAVFKHYDHDRDGFISQEEFQLIAGNFPFIDAFVNIDVDMDGQISKDELKTYFMAANKNTKDLRRGFKHNFHETTFLTPTTCNHCNKLLWGILRQGFKCKDCGLAVHSCCKSNAVAECRRKS 546
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Celegans
Match: Y34B4A.4 (pep chromosome:WBcel235:X:5264330:5271799:1 gene:WBGene00021320.1 transcript:Y34B4A.4a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y34B4A.4) HSP 1 Score: 77.7962 bits (190), Expect = 2.408e-14 Identity = 57/193 (29.53%), Postives = 101/193 (52.33%), Query Frame = 2
Query: 881 KLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYN------RNLINFRKFAQSAATLQSI 1441
++A QLT I+ + + RI +L ++ + L FN LS WV+ +I+ + ER + + KF+ I ++L + NFNS+ A++ I + ++R + S + + L+E+T ++ ++ +Y NYR L + AK +P + + L+DL F H PD + + +N+INF K A L SI
Sbjct: 640 EIACQLTFIDSQLYHRIESAELLWWAQEQNEKKSKNLVNFTEQFNNLSFWVRTLIITQGTQKERERHMMKFVKIMKHLREMCNFNSYLAILSAIMSTPLAR-----LEWSKNIKDALKEHTAVMDTAQSYKNYRALLQTAKPPCVPYIGIILQDLTFVHAGNPDTIPSDRCHGAKNMINFLKRWNQFAILDSI 827
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Celegans
Match: Y34B4A.4 (pep chromosome:WBcel235:X:5264330:5271788:1 gene:WBGene00021320.1 transcript:Y34B4A.4b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y34B4A.4) HSP 1 Score: 77.0258 bits (188), Expect = 3.521e-14 Identity = 57/193 (29.53%), Postives = 101/193 (52.33%), Query Frame = 2
Query: 881 KLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYN------RNLINFRKFAQSAATLQSI 1441
++A QLT I+ + + RI +L ++ + L FN LS WV+ +I+ + ER + + KF+ I ++L + NFNS+ A++ I + ++R + S + + L+E+T ++ ++ +Y NYR L + AK +P + + L+DL F H PD + + +N+INF K A L SI
Sbjct: 640 EIACQLTFIDSQLYHRIESAELLWWAQEQNEKKSKNLVNFTEQFNNLSFWVRTLIITQGTQKERERHMMKFVKIMKHLREMCNFNSYLAILSAIMSTPLAR-----LEWSKNIKDALKEHTAVMDTAQSYKNYRALLQTAKPPCVPYIGIILQDLTFVHAGNPDTIPSDRCHGAKNMINFLKRWNQFAILDSI 827
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Celegans
Match: pxf-1 (Rap guanine nucleotide exchange factor [Source:UniProtKB/Swiss-Prot;Acc:G5EDB9]) HSP 1 Score: 73.559 bits (179), Expect = 6.340e-13 Identity = 57/191 (29.84%), Postives = 98/191 (51.31%), Query Frame = 2
Query: 884 LAEQLTVIEFKAFRRITIQDL--KLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEA--KGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSIL 1444
+A QLT+ +F F I + L+ L + + P LE +FN WV I + +RAK+++KF+ +A L+NFNS +A++ G+ A+ R++++ +S +ML+E +++ S N S YRQ E + +P+ V KDL F H + Y+ LINF K A +++ ++
Sbjct: 898 VAAQLTLQDFSVFSAIEPTEFLDNLFKLDSKYGS-PKLEEFEQLFNREMWWVATEICTERHVQKRAKLIKKFIKVARYCRDLRNFNSMFAIMSGLDKPAVRRLHSSWERVSSKYIRMLDEIHQLVDPSRNMSKYRQHLAEVAQEPPVVPIYPVIKKDLTFAHDG--NATYSEKLINFEKLRLIAKSIRGVM 1085
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Fly
Match: C3G (gene:FBgn0259228 transcript:FBtr0299795) HSP 1 Score: 72.4034 bits (176), Expect = 1.546e-12 Identity = 55/184 (29.89%), Postives = 93/184 (50.54%), Query Frame = 2
Query: 878 LKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEE----YTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQ 1417
L++AEQ+T+++ + F +I I ++ L++ P L + FN +S W + IL ER K V KF+ I ++L + N+NS+ A++ + I R+ QK + E + +I SS+++ YRQ E IP + + L+DL F H D+L ++ +INF K Q
Sbjct: 1004 LEIAEQMTLLDAELFTKIEIPEVLLFAKDQCEEKSPNLNKFTEHFNKMSYWARSKILRLQDAKEREKHVNKFIKIMKHLRKMNNYNSYLALLSALDSGPIRRLE---------WQKGITEEVRSFCALIDSSSSFRAYRQALAETNPPCIPYIGLILQDLTFVHVGNQDYL-SKGVINFSKRWQ 1177
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Fly
Match: C3G (gene:FBgn0259228 transcript:FBtr0334968) HSP 1 Score: 72.4034 bits (176), Expect = 1.546e-12 Identity = 55/184 (29.89%), Postives = 93/184 (50.54%), Query Frame = 2
Query: 878 LKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEE----YTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQ 1417
L++AEQ+T+++ + F +I I ++ L++ P L + FN +S W + IL ER K V KF+ I ++L + N+NS+ A++ + I R+ QK + E + +I SS+++ YRQ E IP + + L+DL F H D+L ++ +INF K Q
Sbjct: 1004 LEIAEQMTLLDAELFTKIEIPEVLLFAKDQCEEKSPNLNKFTEHFNKMSYWARSKILRLQDAKEREKHVNKFIKIMKHLRKMNNYNSYLALLSALDSGPIRRLE---------WQKGITEEVRSFCALIDSSSSFRAYRQALAETNPPCIPYIGLILQDLTFVHVGNQDYL-SKGVINFSKRWQ 1177
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Fly
Match: C3G (gene:FBgn0259228 transcript:FBtr0299792) HSP 1 Score: 72.4034 bits (176), Expect = 1.648e-12 Identity = 55/184 (29.89%), Postives = 93/184 (50.54%), Query Frame = 2
Query: 878 LKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEE----YTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQ 1417
L++AEQ+T+++ + F +I I ++ L++ P L + FN +S W + IL ER K V KF+ I ++L + N+NS+ A++ + I R+ QK + E + +I SS+++ YRQ E IP + + L+DL F H D+L ++ +INF K Q
Sbjct: 1055 LEIAEQMTLLDAELFTKIEIPEVLLFAKDQCEEKSPNLNKFTEHFNKMSYWARSKILRLQDAKEREKHVNKFIKIMKHLRKMNNYNSYLALLSALDSGPIRRLE---------WQKGITEEVRSFCALIDSSSSFRAYRQALAETNPPCIPYIGLILQDLTFVHVGNQDYL-SKGVINFSKRWQ 1228
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Fly
Match: C3G (gene:FBgn0259228 transcript:FBtr0300526) HSP 1 Score: 72.4034 bits (176), Expect = 1.651e-12 Identity = 55/184 (29.89%), Postives = 93/184 (50.54%), Query Frame = 2
Query: 878 LKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEE----YTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQ 1417
L++AEQ+T+++ + F +I I ++ L++ P L + FN +S W + IL ER K V KF+ I ++L + N+NS+ A++ + I R+ QK + E + +I SS+++ YRQ E IP + + L+DL F H D+L ++ +INF K Q
Sbjct: 1341 LEIAEQMTLLDAELFTKIEIPEVLLFAKDQCEEKSPNLNKFTEHFNKMSYWARSKILRLQDAKEREKHVNKFIKIMKHLRKMNNYNSYLALLSALDSGPIRRLE---------WQKGITEEVRSFCALIDSSSSFRAYRQALAETNPPCIPYIGLILQDLTFVHVGNQDYL-SKGVINFSKRWQ 1514
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Fly
Match: C3G (gene:FBgn0259228 transcript:FBtr0299791) HSP 1 Score: 72.4034 bits (176), Expect = 1.652e-12 Identity = 55/184 (29.89%), Postives = 93/184 (50.54%), Query Frame = 2
Query: 878 LKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEE----YTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQ 1417
L++AEQ+T+++ + F +I I ++ L++ P L + FN +S W + IL ER K V KF+ I ++L + N+NS+ A++ + I R+ QK + E + +I SS+++ YRQ E IP + + L+DL F H D+L ++ +INF K Q
Sbjct: 1290 LEIAEQMTLLDAELFTKIEIPEVLLFAKDQCEEKSPNLNKFTEHFNKMSYWARSKILRLQDAKEREKHVNKFIKIMKHLRKMNNYNSYLALLSALDSGPIRRLE---------WQKGITEEVRSFCALIDSSSSFRAYRQALAETNPPCIPYIGLILQDLTFVHVGNQDYL-SKGVINFSKRWQ 1463
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Zebrafish
Match: rasgrp3 (RAS guanyl releasing protein 3 (calcium and DAG-regulated) [Source:ZFIN;Acc:ZDB-GENE-070424-82]) HSP 1 Score: 395.201 bits (1014), Expect = 3.615e-125 Identity = 218/537 (40.60%), Postives = 314/537 (58.47%), Query Frame = 2
Query: 446 FPKIFFLVHNWFSTSESIGRKLYNNADIKHKSDSSFEDDRILRSNRKFKIGGVTLAFCLWIEFYPNDFMGSESCMPILTKFIESLQEMGREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSPVA----NKSILFGDFVSGV-KPPTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKAN---HNALKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECR 2032
P+ F L+H W+ +S + KL + K D +I R WI +P +F + + +F ++ E+G + I L+ S SYD R L+ R ++ V SL+F+ + P++LAE LT +E+K+ RRI+ D + Y + + + PTLERS+ +FNG+SQWVQ M+L+K P RA+V+ K++ +A+ LL LQNFN+ AV+GG++HS+ISR+ T LS K+ E T+++SS+ NY YR+ E+KGF IP++ VHLKDLI H D + + +N K Q T ++ Q +E N+DL L LSLDL YTE++IYELSL REP++ P + NK + D+ SGV P V+ +H+ +V++VF+ YD+D DG IS E+FE +A NFPF+DSF VLD D+DG+ISK EM YFL+AN + F H F E TY KPTFC HC G LWG+IKQG++C+DCG+N HK C+E +V+ CR
Sbjct: 34 LPRTFLLMHRWYVSSTELAGKLLIIYPLAAKHDCQRTRLKICYLMR------------YWIAEFPAEFDLDLGLIRLTEEFRDAAAELGGDKHIKLLDISTIPSYDWMRKLTQR---KKQVKKG---------KASLLFDHLEPIELAEHLTFLEYKSIRRISFTDYQSYVIHGCLVDNPTLERSIALFNGISQWVQLMVLSKLTPQHRAEVITKYIHVAQKLLHLQNFNTLMAVVGGLSHSSISRLKETHSHLSPEVTKIWNEMTELVSSNGNYCAYRKAFGESKGFKIPILGVHLKDLIAVHVVFADWVEDGK-VNIAKMQQLFLTFNELVSLQSAVAQVEPNMDLIYLLNLSLDLYYTEDEIYELSLLREPRNPKSQPTSPTTPNKPLAPLDWASGVTTKPDPSVVNKHIRKVVDSVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRANPLLQCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGVNCHKQCRELLVLACR 545
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Zebrafish
Match: rasgrp3 (RAS guanyl releasing protein 3 (calcium and DAG-regulated) [Source:ZFIN;Acc:ZDB-GENE-070424-82]) HSP 1 Score: 394.815 bits (1013), Expect = 4.061e-125 Identity = 218/537 (40.60%), Postives = 314/537 (58.47%), Query Frame = 2
Query: 446 FPKIFFLVHNWFSTSESIGRKLYNNADIKHKSDSSFEDDRILRSNRKFKIGGVTLAFCLWIEFYPNDFMGSESCMPILTKFIESLQEMGREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSPVA----NKSILFGDFVSGV-KPPTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKAN---HNALKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECR 2032
P+ F L+H W+ +S + KL + K D +I R WI +P +F + + +F ++ E+G + I L+ S SYD R L+ R ++ V SL+F+ + P++LAE LT +E+K+ RRI+ D + Y + + + PTLERS+ +FNG+SQWVQ M+L+K P RA+V+ K++ +A+ LL LQNFN+ AV+GG++HS+ISR+ T LS K+ E T+++SS+ NY YR+ E+KGF IP++ VHLKDLI H D + + +N K Q T ++ Q +E N+DL L LSLDL YTE++IYELSL REP++ P + NK + D+ SGV P V+ +H+ +V++VF+ YD+D DG IS E+FE +A NFPF+DSF VLD D+DG+ISK EM YFL+AN + F H F E TY KPTFC HC G LWG+IKQG++C+DCG+N HK C+E +V+ CR
Sbjct: 34 LPRTFLLMHRWYVSSTELAGKLLIIYPLAAKHDCQRTRLKICYLMR------------YWIAEFPAEFDLDLGLIRLTEEFRDAAAELGGDKHIKLLDISTIPSYDWMRKLTQR---KKQVKKG---------KASLLFDHLEPIELAEHLTFLEYKSIRRISFTDYQSYVIHGCLVDNPTLERSIALFNGISQWVQLMVLSKLTPQHRAEVITKYIHVAQKLLHLQNFNTLMAVVGGLSHSSISRLKETHSHLSPEVTKIWNEMTELVSSNGNYCAYRKAFGESKGFKIPILGVHLKDLIAVHVVFADWVEDGK-VNITKMQQLFLTFNELVSLQSAVAQVEPNMDLIYLLNLSLDLYYTEDEIYELSLLREPRNPKSQPTSPTTPNKPLAPLDWASGVTTKPDPSVVNKHIRKVVDSVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRANPLLQCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGVNCHKQCRELLVLACR 545
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Zebrafish
Match: rasgrp3 (RAS guanyl releasing protein 3 (calcium and DAG-regulated) [Source:ZFIN;Acc:ZDB-GENE-070424-82]) HSP 1 Score: 394.045 bits (1011), Expect = 7.970e-125 Identity = 219/538 (40.71%), Postives = 317/538 (58.92%), Query Frame = 2
Query: 446 FPKIFFLVHNWF-STSESIGRKLYNNADIKHKSDSSFEDDRILRSNRKFKIGGVTLAFCLWIEFYPNDFMGSESCMPILTKFIESLQEMGREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSPVA----NKSILFGDFVSGV-KPPTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKAN---HNALKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECR 2032
P+ F L+H W+ S++E G+ L D + D R+ K + WI +P +F + + +F ++ E+G + I L+ S SYD R L+ R ++ V SL+F+ + P++LAE LT +E+K+ RRI+ D + Y + + + PTLERS+ +FNG+SQWVQ M+L+K P RA+V+ K++ +A+ LL LQNFN+ AV+GG++HS+ISR+ T LS K+ E T+++SS+ NY YR+ E+KGF IP++ VHLKDLI H D + + +N K Q T ++ Q +E N+DL L LSLDL YTE++IYELSL REP++ P + NK + D+ SGV P V+ +H+ +V++VF+ YD+D DG IS E+FE +A NFPF+DSF VLD D+DG+ISK EM YFL+AN + F H F E TY KPTFC HC G LWG+IKQG++C+DCG+N HK C+E +V+ CR
Sbjct: 34 LPRTFLLMHRWYVSSTELAGKLLIMYRDCR--------GDDCQRTRLK-----ICYLMRYWIAEFPAEFDLDLGLIRLTEEFRDAAAELGGDKHIKLLDISTIPSYDWMRKLTQR---KKQVKKG---------KASLLFDHLEPIELAEHLTFLEYKSIRRISFTDYQSYVIHGCLVDNPTLERSIALFNGISQWVQLMVLSKLTPQHRAEVITKYIHVAQKLLHLQNFNTLMAVVGGLSHSSISRLKETHSHLSPEVTKIWNEMTELVSSNGNYCAYRKAFGESKGFKIPILGVHLKDLIAVHVVFADWVEDGK-VNIAKMQQLFLTFNELVSLQSAVAQVEPNMDLIYLLNLSLDLYYTEDEIYELSLLREPRNPKSQPTSPTTPNKPLAPLDWASGVTTKPDPSVVNKHIRKVVDSVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRANPLLQCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGVNCHKQCRELLVLACR 545
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Zebrafish
Match: rasgrp4 (RAS guanyl releasing protein 4 [Source:ZFIN;Acc:ZDB-GENE-050419-110]) HSP 1 Score: 311.612 bits (797), Expect = 6.272e-94 Identity = 221/596 (37.08%), Postives = 322/596 (54.03%), Query Frame = 2
Query: 335 PNIH--IRAATIDKLVEELLIHIEQSCESLDDISDDNLVFPKIFFLVHNWFSTSESIGRKLYNNADIKHKSDSSFEDDRILRSNRKFKIGGVTLAFCLWIEFYPNDFMGSESCMPILTKFIESLQEMGREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSS-IDSPVANKSILFGDFVSGVKPPTVD--VLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKANHNALKNSFK----HEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECRSRGHLYQHNRSSSQSTETNVS 2095
P H R+A++D+L+ L C D + + ++HNW S KL + D E R R+ +I C +I + + F P+L K + L + + + + +N+ Y ++ +++ Q S +K SL+F+ + P ++AE L+ +EFK F ++ D + Y + +VR+ P LERSV + NG+SQWVQ MILN+ +RA+V KF+ +A+ L LQNFN+ AVIGG+ HS+ISR+ T LS K L E T+++SS +NYSNYR++ E GF +P++ VHLKDLI + ALPD+L + + IN K + + +L E N DL + L LSLDL YTE++IYELS A+EPK+ I K + ++ SGV P +D + +HV MV+++ K YD + DG IS EEFE +A NFPF SF ++D++G IS+ E+ YF++ K F H F+E TY +PTFC C G LWG+IKQG+ C+DCG+N HKHCK+ V MEC R Q N SS T VS
Sbjct: 48 PPAHASFRSASLDELILRCL-----HCFDSDGKLNRGTQLVSMTLMMHNWVVPSHIFAHKL-----LSLYKDCPAEK----RGQRRPQI-------CHFIRQWISQFRLMFEMDPLLEKAMGDLWALVSAEGTNSHHQLINTPY-----INPPVNISQTPSPLVK-----KRKVSLLFDHMEPDEMAEHLSYLEFKNFCNVSFLDYRSYVVHGSVRDNPALERSVMLCNGVSQWVQLMILNRHTSQQRAEVFTKFIHVAQKLRSLQNFNTLMAVIGGLCHSSISRLKDTASLLSSDVTKTLSELTELLSSYSNYSNYRRVYSECTGFKVPILGVHLKDLISLNEALPDYLED-DKINLGKLQHLYSNISDLLAIHDCTPPFEANKDLLHLLTLSLDLYYTEDEIYELSYAKEPKNPKIQPVAPVKPPVVAEWGSGVT-PRLDPATISKHVKQMVDSIMKNYDLNMDGYISLEEFEKIAANFPF--SFCTHESDREGEISREEITSYFMRGMSVCAKLGFNLHNLHNFHETTYKRPTFCDTCGGFLWGVIKQGYHCKDCGVNCHKHCKDVVGMECLKR---LQVNSSSCPCTPGPVS 605
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Zebrafish
Match: rasgrp4 (RAS guanyl releasing protein 4 [Source:ZFIN;Acc:ZDB-GENE-050419-110]) HSP 1 Score: 311.612 bits (797), Expect = 6.272e-94 Identity = 221/596 (37.08%), Postives = 322/596 (54.03%), Query Frame = 2
Query: 335 PNIH--IRAATIDKLVEELLIHIEQSCESLDDISDDNLVFPKIFFLVHNWFSTSESIGRKLYNNADIKHKSDSSFEDDRILRSNRKFKIGGVTLAFCLWIEFYPNDFMGSESCMPILTKFIESLQEMGREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSS-IDSPVANKSILFGDFVSGVKPPTVD--VLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKANHNALKNSFK----HEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECRSRGHLYQHNRSSSQSTETNVS 2095
P H R+A++D+L+ L C D + + ++HNW S KL + D E R R+ +I C +I + + F P+L K + L + + + + +N+ Y ++ +++ Q S +K SL+F+ + P ++AE L+ +EFK F ++ D + Y + +VR+ P LERSV + NG+SQWVQ MILN+ +RA+V KF+ +A+ L LQNFN+ AVIGG+ HS+ISR+ T LS K L E T+++SS +NYSNYR++ E GF +P++ VHLKDLI + ALPD+L + + IN K + + +L E N DL + L LSLDL YTE++IYELS A+EPK+ I K + ++ SGV P +D + +HV MV+++ K YD + DG IS EEFE +A NFPF SF ++D++G IS+ E+ YF++ K F H F+E TY +PTFC C G LWG+IKQG+ C+DCG+N HKHCK+ V MEC R Q N SS T VS
Sbjct: 48 PPAHASFRSASLDELILRCL-----HCFDSDGKLNRGTQLVSMTLMMHNWVVPSHIFAHKL-----LSLYKDCPAEK----RGQRRPQI-------CHFIRQWISQFRLMFEMDPLLEKAMGDLWALVSAEGTNSHHQLINTPY-----INPPVNISQTPSPLVK-----KRKVSLLFDHMEPDEMAEHLSYLEFKNFCNVSFLDYRSYVVHGSVRDNPALERSVMLCNGVSQWVQLMILNRHTSQQRAEVFTKFIHVAQKLRSLQNFNTLMAVIGGLCHSSISRLKDTASLLSSDVTKTLSELTELLSSYSNYSNYRRVYSECTGFKVPILGVHLKDLISLNEALPDYLED-DKINLGKLQHLYSNISDLLAIHDCTPPFEANKDLLHLLTLSLDLYYTEDEIYELSYAKEPKNPKIQPVAPVKPPVVAEWGSGVT-PRLDPATISKHVKQMVDSIMKNYDLNMDGYISLEEFEKIAANFPF--SFCTHESDREGEISREEITSYFMRGMSVCAKLGFNLHNLHNFHETTYKRPTFCDTCGGFLWGVIKQGYHCKDCGVNCHKHCKDVVGMECLKR---LQVNSSSCPCTPGPVS 605
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Xenopus
Match: anks3 (ankyrin repeat and sterile alpha motif domain containing 3 [Source:Xenbase;Acc:XB-GENE-999239]) HSP 1 Score: 379.793 bits (974), Expect = 1.919e-119 Identity = 226/583 (38.77%), Postives = 330/583 (56.60%), Query Frame = 2
Query: 446 FPKIFFLVHNWFSTSESIGRKLYNNADI-KHKSDSSFEDDRILRSNRKFKIGGVTLAFCLWIEFYPNDF---MGSESCMPILTKFIESLQEMGREDLITTLEKSLNS---------SYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLA---REPKSSIDSPVANKSILFGDFVSGV-KPPTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKAN---HNALKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECRSRGHLYQHNRSSSQSTETNVSFQSLGSPPCSSRQ 2134
P+I L+H W+ S + KL + +H ++ + +R WI +P +F +G L + +E +E+ ++ S SYD R ++ R K S + C L+F+ + P++LAE LT +E+KAFRRI+ D + Y + + + PTLERS+ +FNG+S+WVQ M+L+K +P +RA+V+ K++ IA+ LL LQNFN+ +V+GG++HS+ISR+ T L K+ E T+++SS+ NY NYR+ E +GF IP++ VHLKDLI H PD + + N +N K Q TL ++ Q +E ++DL N L LSLDL +TE+DIY+LSL R PKS NK ++ D+ + V P +++ +H+ +VE+VF+ YD+D DG IS E+FE +A NFPF+DSF VLD D+DG ISK EM YFL+A H L F H F E TY KPTFC HC G LWG+IKQG++C+DCG N HK CK+ +V+ CR +H+R +S +T N S S SP + Q
Sbjct: 27 LPRIVLLMHRWYLPSTELAGKLLSIYPFGEHCNEHRLKTCYFIR---------------YWILEFPAEFNLDLG-------LIRLMEEFRELAFNRILFLFTDFCFSYILQVWDLPSYDWMRRVTQR-----------KKTSKKGKVC-LLFDHLEPIELAEHLTFLEYKAFRRISFTDYQSYVIHGCLEDNPTLERSIALFNGISKWVQLMVLSKQSPQQRAQVITKYIYIAQKLLQLQNFNTLMSVVGGLSHSSISRLKDTHAHLCADVTKVWNEMTELVSSNGNYCNYRKAFAECEGFKIPILGVHLKDLIAVHVIFPDWI-DDNKVNIAKMQQLYVTLNELVSLQSASHHLETSMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNPKSPTSPTTPNKPVVPLDWAAVVTTKPDPNIISKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGRISKSEMMAYFLRAKSQFHCKLGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGFKCKDCGANCHKQCKDLLVLACR------KHSRGAS-TTRNNGSLPS--SPSLAPAQ 565
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Xenopus
Match: rasgrp1 (RAS guanyl releasing protein 1 [Source:NCBI gene;Acc:100101791]) HSP 1 Score: 372.089 bits (954), Expect = 3.040e-117 Identity = 203/461 (44.03%), Postives = 290/461 (62.91%), Query Frame = 2
Query: 677 LTKFIESLQEMGREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSPV-ANKSILFGDFVSGVKP-PTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKANH--NALKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECRSRGHL 2047
LT+ +E QE+ R + ++++ SR S +++ R +K S SL+F+ + P +LAE LT +EFKAFRRI+ D + Y ++ V+ PT+ERS+ + NG+SQWVQ M+L++ P RA+V+ KF+ +A+ L LQNFN+ AVIGG+ HS+ISR+ T +S K+L E T+++SS NY NYR++ E F IP++ VHLKDLI H A+PD L + IN K + ++ Q +E N+DL + L LSLDL YTE+++YELS AREP++ PV +K + D+ SGV P P + +HV MV++VFK YD D+DG IS EEFE +A +FPF SF V+D D++G+IS+ E+ YF++A+ + L F H F E TY +PTFC +C G LWG+IKQG+RC+DCG+N HK CKE VV EC+ R L
Sbjct: 29 LTQAMEEFQELVRSKGEELHWRLIDTAQINSRDWSRKLTQR------IKPNCSKKRKVSLLFDHLEPQELAEHLTYLEFKAFRRISFSDYQNYIVSGCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVLTKFIHVAQKLHQLQNFNTLMAVIGGLCHSSISRLKDTSAHVSHDVNKVLNEMTELLSSCRNYDNYRRVYNECTNFKIPILGVHLKDLIALHEAMPDFLEDSK-INVPKLHSLYNHINELIQLQNIAPPLEANMDLVHLLTLSLDLYYTEDEMYELSYAREPRNHRAPPVTPSKPPVVADWASGVSPKPDPKTISKHVQRMVDSVFKNYDLDQDGYISQEEFEKIAASFPF--SFCVMDKDREGLISRQEITAYFMRASSICSKLGLGFLHNFQETTYLRPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKELVVFECKKRSKL 480
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Xenopus
Match: rasgrp1 (RAS guanyl releasing protein 1 [Source:NCBI gene;Acc:100101791]) HSP 1 Score: 372.859 bits (956), Expect = 1.465e-115 Identity = 209/494 (42.31%), Postives = 300/494 (60.73%), Query Frame = 2
Query: 578 NRKFKIGGVTLAFCLWIEFYPNDFMGSESCMPILTKFIESLQEMGREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSPV-ANKSILFGDFVSGVKP-PTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKANH--NALKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECRSRGHL 2047
NR F L C +I ++ + LT+ +E QE+ R + ++++ SR S +++ R +K S SL+F+ + P +LAE LT +EFKAFRRI+ D + Y ++ V+ PT+ERS+ + NG+SQWVQ M+L++ P RA+V+ KF+ +A+ L LQNFN+ AVIGG+ HS+ISR+ T +S K+L E T+++SS NY NYR++ E F IP++ VHLKDLI H A+PD L + IN K + ++ Q +E N+DL + L LSLDL YTE+++YELS AREP++ PV +K + D+ SGV P P + +HV MV++VFK YD D+DG IS EEFE +A +FPF SF V+D D++G+IS+ E+ YF++A+ + L F H F E TY +PTFC +C G LWG+IKQG+RC+DCG+N HK CKE VV EC+ R L
Sbjct: 132 NRSFSF---CLRICYFIRYWVTELWVMFKMDAKLTQAMEEFQELVRSKGEELHWRLIDTAQINSRDWSRKLTQR------IKPNCSKKRKVSLLFDHLEPQELAEHLTYLEFKAFRRISFSDYQNYIVSGCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVLTKFIHVAQKLHQLQNFNTLMAVIGGLCHSSISRLKDTSAHVSHDVNKVLNEMTELLSSCRNYDNYRRVYNECTNFKIPILGVHLKDLIALHEAMPDFLEDSK-INVPKLHSLYNHINELIQLQNIAPPLEANMDLVHLLTLSLDLYYTEDEMYELSYAREPRNHRAPPVTPSKPPVVADWASGVSPKPDPKTISKHVQRMVDSVFKNYDLDQDGYISQEEFEKIAASFPF--SFCVMDKDREGLISRQEITAYFMRASSICSKLGLGFLHNFQETTYLRPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKELVVFECKKRSKL 613
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Xenopus
Match: rasgrp1 (RAS guanyl releasing protein 1 [Source:NCBI gene;Acc:100101791]) HSP 1 Score: 372.474 bits (955), Expect = 1.747e-115 Identity = 206/484 (42.56%), Postives = 297/484 (61.36%), Query Frame = 2
Query: 608 LAFCLWIEFYPNDFMGSESCMPILTKFIESLQEMGREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSPV-ANKSILFGDFVSGVKP-PTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKANH--NALKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECRSRGHL 2047
L C +I ++ + LT+ +E QE+ R + ++++ SR S +++ R +K S SL+F+ + P +LAE LT +EFKAFRRI+ D + Y ++ V+ PT+ERS+ + NG+SQWVQ M+L++ P RA+V+ KF+ +A+ L LQNFN+ AVIGG+ HS+ISR+ T +S K+L E T+++SS NY NYR++ E F IP++ VHLKDLI H A+PD L + IN K + ++ Q +E N+DL + L LSLDL YTE+++YELS AREP++ PV +K + D+ SGV P P + +HV MV++VFK YD D+DG IS EEFE +A +FPF SF V+D D++G+IS+ E+ YF++A+ + L F H F E TY +PTFC +C G LWG+IKQG+RC+DCG+N HK CKE VV EC+ R L
Sbjct: 121 LRICYFIRYWVTELWVMFKMDAKLTQAMEEFQELVRSKGEELHWRLIDTAQINSRDWSRKLTQR------IKPNCSKKRKVSLLFDHLEPQELAEHLTYLEFKAFRRISFSDYQNYIVSGCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVLTKFIHVAQKLHQLQNFNTLMAVIGGLCHSSISRLKDTSAHVSHDVNKVLNEMTELLSSCRNYDNYRRVYNECTNFKIPILGVHLKDLIALHEAMPDFLEDSK-INVPKLHSLYNHINELIQLQNIAPPLEANMDLVHLLTLSLDLYYTEDEMYELSYAREPRNHRAPPVTPSKPPVVADWASGVSPKPDPKTISKHVQRMVDSVFKNYDLDQDGYISQEEFEKIAASFPF--SFCVMDKDREGLISRQEITAYFMRASSICSKLGLGFLHNFQETTYLRPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKELVVFECKKRSKL 595
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Xenopus
Match: rasgrp1 (RAS guanyl releasing protein 1 [Source:NCBI gene;Acc:100101791]) HSP 1 Score: 372.474 bits (955), Expect = 2.083e-115 Identity = 206/484 (42.56%), Postives = 297/484 (61.36%), Query Frame = 2
Query: 608 LAFCLWIEFYPNDFMGSESCMPILTKFIESLQEMGREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSPV-ANKSILFGDFVSGVKP-PTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKANH--NALKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECRSRGHL 2047
L C +I ++ + LT+ +E QE+ R + ++++ SR S +++ R +K S SL+F+ + P +LAE LT +EFKAFRRI+ D + Y ++ V+ PT+ERS+ + NG+SQWVQ M+L++ P RA+V+ KF+ +A+ L LQNFN+ AVIGG+ HS+ISR+ T +S K+L E T+++SS NY NYR++ E F IP++ VHLKDLI H A+PD L + IN K + ++ Q +E N+DL + L LSLDL YTE+++YELS AREP++ PV +K + D+ SGV P P + +HV MV++VFK YD D+DG IS EEFE +A +FPF SF V+D D++G+IS+ E+ YF++A+ + L F H F E TY +PTFC +C G LWG+IKQG+RC+DCG+N HK CKE VV EC+ R L
Sbjct: 135 LRICYFIRYWVTELWVMFKMDAKLTQAMEEFQELVRSKGEELHWRLIDTAQINSRDWSRKLTQR------IKPNCSKKRKVSLLFDHLEPQELAEHLTYLEFKAFRRISFSDYQNYIVSGCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVLTKFIHVAQKLHQLQNFNTLMAVIGGLCHSSISRLKDTSAHVSHDVNKVLNEMTELLSSCRNYDNYRRVYNECTNFKIPILGVHLKDLIALHEAMPDFLEDSK-INVPKLHSLYNHINELIQLQNIAPPLEANMDLVHLLTLSLDLYYTEDEMYELSYAREPRNHRAPPVTPSKPPVVADWASGVSPKPDPKTISKHVQRMVDSVFKNYDLDQDGYISQEEFEKIAASFPF--SFCVMDKDREGLISRQEITAYFMRASSICSKLGLGFLHNFQETTYLRPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKELVVFECKKRSKL 609
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Mouse
Match: Rasgrp3 (RAS, guanyl releasing protein 3 [Source:MGI Symbol;Acc:MGI:3028579]) HSP 1 Score: 397.512 bits (1020), Expect = 2.367e-126 Identity = 230/573 (40.14%), Postives = 336/573 (58.64%), Query Frame = 2
Query: 350 RAATIDKLVEELLIHIEQSCESLDDISDDNLVF-PKIFFLVHNWFSTSESIGRKL---YNNADIKHKSDSSFEDDRILRSNRKFKIGGVTLAFCLWIEFYPNDFMGSESCMPILTKFIESLQEMGREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSPVA----NKSILFGDFVSGVKP-PTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKAN---HNALKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECR 2032
+AAT+D+L+ + E DD D N + P+I L+H W+ +S + KL Y NA S S ++ R+ + WI +P +F + + +F E ++G E I+ ++ S SYD R ++ R V S + C L+F+ + P++LAE LT +E K+FRRI+ D + Y + + N PTLERS+ +FNG+S+WVQ M+L+K + +RA+V+ KF+ +A+ LL L+NFN+ AV+GG++HS+ISR+ T LS K E T+++SS+ NY NYR+ + GF IP++ VHLKDLI H PD + N +N K Q + TL ++ Q +E N+DL N L LSLDL +TE+DIY+LSL EP++S P + NK ++ ++ S V P P ++ +H+ +VE+VF+ YD+D DG IS E+FE +A NFPF+DSF VLD D+DG+ISK EM YFL+A H + F H F E Y KPTFC HC G LWG+IKQG++C+DCG N HK CK+ +V+ CR
Sbjct: 8 KAATLDELLSTCI-------EMFDDNGDLNDSYLPRIVLLMHRWYLSSTELAGKLLCMYRNA-----SGESCDEFRL----------KICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGHEKHISLMDISSVPSYDWMRRVTQRKKV-----------SKRGKAC-LLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPSAQQRAEVITKFINVAQKLLQLKNFNTLMAVVGGLSHSSISRLKDTHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWM-EENKVNVVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWASEVVPKPDPTIINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMNYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACR 545
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Mouse
Match: Rasgrp3 (RAS, guanyl releasing protein 3 [Source:MGI Symbol;Acc:MGI:3028579]) HSP 1 Score: 397.512 bits (1020), Expect = 2.367e-126 Identity = 230/573 (40.14%), Postives = 336/573 (58.64%), Query Frame = 2
Query: 350 RAATIDKLVEELLIHIEQSCESLDDISDDNLVF-PKIFFLVHNWFSTSESIGRKL---YNNADIKHKSDSSFEDDRILRSNRKFKIGGVTLAFCLWIEFYPNDFMGSESCMPILTKFIESLQEMGREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSPVA----NKSILFGDFVSGVKP-PTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKAN---HNALKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECR 2032
+AAT+D+L+ + E DD D N + P+I L+H W+ +S + KL Y NA S S ++ R+ + WI +P +F + + +F E ++G E I+ ++ S SYD R ++ R V S + C L+F+ + P++LAE LT +E K+FRRI+ D + Y + + N PTLERS+ +FNG+S+WVQ M+L+K + +RA+V+ KF+ +A+ LL L+NFN+ AV+GG++HS+ISR+ T LS K E T+++SS+ NY NYR+ + GF IP++ VHLKDLI H PD + N +N K Q + TL ++ Q +E N+DL N L LSLDL +TE+DIY+LSL EP++S P + NK ++ ++ S V P P ++ +H+ +VE+VF+ YD+D DG IS E+FE +A NFPF+DSF VLD D+DG+ISK EM YFL+A H + F H F E Y KPTFC HC G LWG+IKQG++C+DCG N HK CK+ +V+ CR
Sbjct: 8 KAATLDELLSTCI-------EMFDDNGDLNDSYLPRIVLLMHRWYLSSTELAGKLLCMYRNA-----SGESCDEFRL----------KICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGHEKHISLMDISSVPSYDWMRRVTQRKKV-----------SKRGKAC-LLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPSAQQRAEVITKFINVAQKLLQLKNFNTLMAVVGGLSHSSISRLKDTHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWM-EENKVNVVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWASEVVPKPDPTIINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMNYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACR 545
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Mouse
Match: Rasgrp1 (RAS guanyl releasing protein 1 [Source:MGI Symbol;Acc:MGI:1314635]) HSP 1 Score: 361.688 bits (927), Expect = 1.227e-111 Identity = 203/488 (41.60%), Postives = 298/488 (61.07%), Query Frame = 2
Query: 599 GVTLAFCLWIEFYPNDFMGSESCMPILTKFIESLQEM----GREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSPV-ANKSILFGDFVSGVKP-PTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKAN--HNALKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECRSR 2038
GV L C ++ ++ +F LT +E Q++ G E ++ + +S D SR L+ R +K +S SL+F+ + P +L+E LT +EFK+FRRI+ D + Y + + V+ PT+ERS+ + NG+SQWVQ M+L++ P RA+V KF+ +A+ L LQNFN+ AVIGG+ HS+ISR+ T + K+L E T+++SS NY NYR+ E F IP++ VHLKDLI + A+PD+L + +N +K + ++ Q ++ N DL + L LSLDL YTE++IYELS AREP++ P+ +K + D+ SGV P P + +HV MV++VFK YD D+DG IS EEFE +A +FPF SF V+D D++G+IS+ E+ YF++A+ ++ L F H F E TY KPTFC +C G LWG+IKQG+RC+DCG+N HK CK+ VV EC+ R
Sbjct: 120 GVCLKICYFVRYWITEFWIMFKMDASLTSTMEEFQDLVKANGEETHCHLIDTTQINSRDWSRKLTQR----------IKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIHVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSCRNYDNYRRAYGECTHFKIPILGVHLKDLISLYEAMPDYLEDGK-VNVQKLLALYNHINELVQLQEMAPPLDANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASGVSPKPDPKTISKHVQRMVDSVFKNYDLDQDGYISQEEFEKIAASFPF--SFCVMDKDREGLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKR 594
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Mouse
Match: Rasgrp1 (RAS guanyl releasing protein 1 [Source:MGI Symbol;Acc:MGI:1314635]) HSP 1 Score: 361.688 bits (927), Expect = 1.227e-111 Identity = 203/488 (41.60%), Postives = 298/488 (61.07%), Query Frame = 2
Query: 599 GVTLAFCLWIEFYPNDFMGSESCMPILTKFIESLQEM----GREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSPV-ANKSILFGDFVSGVKP-PTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKAN--HNALKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECRSR 2038
GV L C ++ ++ +F LT +E Q++ G E ++ + +S D SR L+ R +K +S SL+F+ + P +L+E LT +EFK+FRRI+ D + Y + + V+ PT+ERS+ + NG+SQWVQ M+L++ P RA+V KF+ +A+ L LQNFN+ AVIGG+ HS+ISR+ T + K+L E T+++SS NY NYR+ E F IP++ VHLKDLI + A+PD+L + +N +K + ++ Q ++ N DL + L LSLDL YTE++IYELS AREP++ P+ +K + D+ SGV P P + +HV MV++VFK YD D+DG IS EEFE +A +FPF SF V+D D++G+IS+ E+ YF++A+ ++ L F H F E TY KPTFC +C G LWG+IKQG+RC+DCG+N HK CK+ VV EC+ R
Sbjct: 120 GVCLKICYFVRYWITEFWIMFKMDASLTSTMEEFQDLVKANGEETHCHLIDTTQINSRDWSRKLTQR----------IKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIHVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSCRNYDNYRRAYGECTHFKIPILGVHLKDLISLYEAMPDYLEDGK-VNVQKLLALYNHINELVQLQEMAPPLDANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASGVSPKPDPKTISKHVQRMVDSVFKNYDLDQDGYISQEEFEKIAASFPF--SFCVMDKDREGLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKR 594
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Mouse
Match: Rasgrp1 (RAS guanyl releasing protein 1 [Source:MGI Symbol;Acc:MGI:1314635]) HSP 1 Score: 330.102 bits (845), Expect = 6.212e-102 Identity = 192/486 (39.51%), Postives = 279/486 (57.41%), Query Frame = 2
Query: 599 GVTLAFCLWIEFYPNDFMGSESCMPILTKFIESLQEM----GREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSPVANKSILFGDFVSGVKPPTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKAN--HNALKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECRSR 2038
GV L C ++ ++ +F LT +E Q++ G E ++ + +S D SR L+ R +K +S SL+F+ + P +L+E LT +EFK+FRRI+ D + Y + + V+ PT+ERS+ + NG+SQWVQ M+L++ P RA+V KF+ +A+ L LQNFN+ AVIGG+ HS+ISR+ T + K+L E T+++SS NY NYR+ E F IP++ VHLKDLI + A+PD+L + +N +K + ++ Q ++ N DL + L LSLDL YTE++IYELS AREP+ N +VFK YD D+DG IS EEFE +A +FPF SF V+D D++G+IS+ E+ YF++A+ ++ L F H F E TY KPTFC +C G LWG+IKQG+RC+DCG+N HK CK+ VV EC+ R
Sbjct: 120 GVCLKICYFVRYWITEFWIMFKMDASLTSTMEEFQDLVKANGEETHCHLIDTTQINSRDWSRKLTQR----------IKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIHVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSCRNYDNYRRAYGECTHFKIPILGVHLKDLISLYEAMPDYLEDGK-VNVQKLLALYNHINELVQLQEMAPPLDANKDLVHLLTLSLDLYYTEDEIYELSYAREPR---------------------------------NHRAPSVFKNYDLDQDGYISQEEFEKIAASFPF--SFCVMDKDREGLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKR 559
BLAST of Ras guanyl-releasing protein 3 vs. UniProt/SwissProt
Match: sp|Q8IV61|GRP3_HUMAN (Ras guanyl-releasing protein 3 OS=Homo sapiens OX=9606 GN=RASGRP3 PE=1 SV=1) HSP 1 Score: 402.519 bits (1033), Expect = 2.138e-127 Identity = 231/573 (40.31%), Postives = 336/573 (58.64%), Query Frame = 2
Query: 350 RAATIDKLVEELLIHIEQSCESLDDISD-DNLVFPKIFFLVHNWFSTSESIGRKL---YNNADIKHKSDSSFEDDRILRSNRKFKIGGVTLAFCLWIEFYPNDFMGSESCMPILTKFIESLQEMGREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSPVA----NKSILFGDFVSGVKP-PTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKAN---HNALKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECR 2032
+AAT+D+L+ + E DD + DN P+I L+H W+ +S + KL Y NA + S +F++ + WI +P +F + + +F E ++G E ++ ++ S SYD R ++ R V S + C L+F+ + P++LAE LT +E K+FRRI+ D + Y + + N PTLERS+ +FNG+S+WVQ M+L+K P +RA+V+ KF+ +A+ LL L+NFN+ AV+GG++HS+ISR+ T LS K E T+++SS+ NY NYR+ + GF IP++ VHLKDLI H PD N +N K Q + TL ++ Q +E N+DL N L LSLDL +TE+DIY+LSL EP++S P + NK ++ ++ GV P P V+ +H+ +VE+VF+ YD+D DG IS E+FE +A NFPF+DSF VLD D+DG+ISK EM YFL+A H + F H F E TY KPTFC HC G LWG+IKQG++C+DCG N HK CK+ +V+ CR
Sbjct: 8 KAATLDELLCTCI-------EMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGE--------------SCNEFRLK-ICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSIPSYDWMRRVTQRKKV-----------SKKGKAC-LLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPD-WTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACR 545
BLAST of Ras guanyl-releasing protein 3 vs. UniProt/SwissProt
Match: sp|A4IJ06|GRP1_XENTR (RAS guanyl-releasing protein 1 OS=Xenopus tropicalis OX=8364 GN=rasgrp1 PE=2 SV=1) HSP 1 Score: 372.859 bits (956), Expect = 5.734e-115 Identity = 209/494 (42.31%), Postives = 300/494 (60.73%), Query Frame = 2
Query: 578 NRKFKIGGVTLAFCLWIEFYPNDFMGSESCMPILTKFIESLQEMGREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSPV-ANKSILFGDFVSGVKP-PTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKANH--NALKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECRSRGHL 2047
NR F L C +I ++ + LT+ +E QE+ R + ++++ SR S +++ R +K S SL+F+ + P +LAE LT +EFKAFRRI+ D + Y ++ V+ PT+ERS+ + NG+SQWVQ M+L++ P RA+V+ KF+ +A+ L LQNFN+ AVIGG+ HS+ISR+ T +S K+L E T+++SS NY NYR++ E F IP++ VHLKDLI H A+PD L + IN K + ++ Q +E N+DL + L LSLDL YTE+++YELS AREP++ PV +K + D+ SGV P P + +HV MV++VFK YD D+DG IS EEFE +A +FPF SF V+D D++G+IS+ E+ YF++A+ + L F H F E TY +PTFC +C G LWG+IKQG+RC+DCG+N HK CKE VV EC+ R L
Sbjct: 112 NRSFSF---CLRICYFIRYWVTELWVMFKMDAKLTQAMEEFQELVRSKGEELHWRLIDTAQINSRDWSRKLTQR------IKPNCSKKRKVSLLFDHLEPQELAEHLTYLEFKAFRRISFSDYQNYIVSGCVKENPTMERSIALCNGISQWVQFMVLSRPTPQLRAEVLTKFIHVAQKLHQLQNFNTLMAVIGGLCHSSISRLKDTSAHVSHDVNKVLNEMTELLSSCRNYDNYRRVYNECTNFKIPILGVHLKDLIALHEAMPDFLEDSK-INVPKLHSLYNHINELIQLQNIAPPLEANMDLVHLLTLSLDLYYTEDEMYELSYAREPRNHRAPPVTPSKPPVVADWASGVSPKPDPKTISKHVQRMVDSVFKNYDLDQDGYISQEEFEKIAASFPF--SFCVMDKDREGLISRQEITAYFMRASSICSKLGLGFLHNFQETTYLRPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKELVVFECKKRSKL 593
BLAST of Ras guanyl-releasing protein 3 vs. UniProt/SwissProt
Match: sp|Q6NTL4|GRP1_XENLA (RAS guanyl-releasing protein 1 OS=Xenopus laevis OX=8355 GN=rasgrp1 PE=2 SV=1) HSP 1 Score: 368.622 bits (945), Expect = 2.484e-113 Identity = 212/495 (42.83%), Postives = 299/495 (60.40%), Query Frame = 2
Query: 578 NRKFKIGGVTLAFCLWIEFYPNDFMGSESCMPILTKFIESLQEM----GREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSPV-ANKSILFGDFVSGVKP-PTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKANH--NALKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECRSR 2038
NR F L C +I ++ + LT+ +E QE+ G E ++ + +S D SR L+ R+ SN S SL+F+ + P +LAE LT +EFKAFRRI+ D + Y + V++ PT+ERS+ + NG+SQWVQ M+L++ P RA+V+ KF+ +A+ L LQNFN+ AVIGG+ HS+ISR+ T +S K+L E T+++SS NY NYR+ E F IP++ VHLKDLI H A+PD L + IN K + ++ Q +E N+DL + L LSLDL YTE+++YELS AREP++ PV +K + D+ SGV P P + +HV MV++VFK YD D+DG IS EEFE +A +FPF SF V+D D++G+IS+ E+ YF++A+ + L F H F E TY +PTFC +C G LWG+IKQG+RC+DCG+N HK CKE VV EC+ R
Sbjct: 112 NRSFSF---CLRICYFIRYWITELWVMFKMDAKLTQTMEEFQELVRSHGEELHWRLIDTAQINSRDWSRKLTQRIQ-----SNC-----SKKRKVSLLFDHLEPQELAEHLTYLEFKAFRRISFSDYQNYIVNGCVKDNPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVLTKFIHVAQKLHQLQNFNTLMAVIGGLCHSSISRLKDTSSHVSHDVTKVLNEMTELLSSCRNYDNYRRAYNECTNFKIPILGVHLKDLIALHEAMPDFL-EESKINVPKLHSLYNHINELIQLQNIAPPLEANMDLVHLLTLSLDLYYTEDEMYELSYAREPRNYRAPPVTPSKPPVVADWASGVSPKPDPKTISKHVQRMVDSVFKNYDLDQDGYISQEEFEKIAASFPF--SFCVMDKDREGLISRQEITAYFMRASSICSKLGLGFLHNFQETTYLRPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKELVVFECKKR 590
BLAST of Ras guanyl-releasing protein 3 vs. UniProt/SwissProt
Match: sp|O95267|GRP1_HUMAN (RAS guanyl-releasing protein 1 OS=Homo sapiens OX=9606 GN=RASGRP1 PE=1 SV=2) HSP 1 Score: 364.77 bits (935), Expect = 7.426e-112 Identity = 208/507 (41.03%), Postives = 305/507 (60.16%), Query Frame = 2
Query: 599 GVTLAFCLWIEFYPNDFMGSESCMPILTKFIESLQEM----GREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSPV-ANKSILFGDFVSGVKP-PTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKAN--HNALKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECRSRGHLYQHNRSSSQSTETNVS 2095
G+ L C ++ ++ +F LT +E QE+ G E ++ + ++ D SR L+ R +K +S SL+F+ + P +L+E LT +EFK+FRRI+ D + Y + + V+ PT+ERS+ + NG+SQWVQ M+L++ P RA+V KF+ +A+ L LQNFN+ AVIGG+ HS+ISR+ T + K+L E T+++SSS NY NYR+ E F IP++ VHLKDLI + A+PD+L + +N K + ++ Q +E N DL + L LSLDL YTE++IYELS AREP++ P+ +K + D+ SGV P P + +HV MV++VFK YD+D+DG IS EEFE +A +FPF SF V+D D++G+IS+ E+ YF++A+ ++ L F H F E TY KPTFC +C G LWG+IKQG+RC+DCG+N HK CK+ VV EC+ R ++ TE N S
Sbjct: 120 GLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELVKAKGEELHCRLIDTTQINARDWSRKLTQR----------IKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGK-VNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASGVSPKPDPKTISKHVQRMVDSVFKNYDHDQDGYISQEEFEKIAASFPF--SFCVMDKDREGLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKRA------KNPVAPTENNTS 607
BLAST of Ras guanyl-releasing protein 3 vs. UniProt/SwissProt
Match: sp|Q9R1K8|GRP1_RAT (RAS guanyl-releasing protein 1 OS=Rattus norvegicus OX=10116 GN=Rasgrp1 PE=1 SV=1) HSP 1 Score: 362.073 bits (928), Expect = 6.683e-111 Identity = 208/507 (41.03%), Postives = 308/507 (60.75%), Query Frame = 2
Query: 599 GVTLAFCLWIEFYPNDFMGSESCMPILTKFIESLQEM----GREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSPV-ANKSILFGDFVSGVKP-PTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKAN--HNALKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECRSRGHLYQHNRSSSQSTETNVS 2095
G+ L C ++ ++ +F LT +E Q++ G E ++ + +S D SR L+ R +K +S SL+F+ + P +L+E LT +EFK+FRRI+ D + Y + + V+ PT+ERS+ + NG+SQWVQ M+L++ P RA+V KF+ +A+ L LQNFN+ AVIGG+ HS+ISR+ T + K+L E T+++SS NY NYR+ E F IP++ VHLKDLI + A+PD+L + +N +K + ++ Q ++ N DL + L LSLDL YTE++IYELS AREP++ P+ +K + D+ SGV P P + +HV MV++VFK YD D+DG IS EEFE +A +FPF SF V+D D++G+IS+ E+ YF++A+ ++ L F H F E TY KPTFC +C G LWG+IKQG+RC+DCG+N HK CK+ VV EC+ R ++S + STE N+S
Sbjct: 120 GICLKICYFVRYWITEFWIMFKMDASLTSTMEEFQDLVKANGEESHCHLIDTTQINSRDWSRKLTQR----------IKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIHVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSCRNYDNYRRAYGECTHFKIPILGVHLKDLISLYEAMPDYLEDGK-VNVQKLLALYNHINELVQLQDVAPPLDANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASGVSPKPDPKTISKHVQRMVDSVFKNYDLDQDGYISQEEFEKIAASFPF--SFCVMDKDREGLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKR------SKSPAVSTE-NIS 606
BLAST of Ras guanyl-releasing protein 3 vs. TrEMBL
Match: A0A1S3HKQ6 (ras guanyl-releasing protein 3 isoform X3 OS=Lingula unguis OX=7574 GN=LOC106156052 PE=4 SV=1) HSP 1 Score: 543.502 bits (1399), Expect = 1.756e-178 Identity = 323/744 (43.41%), Postives = 454/744 (61.02%), Query Frame = 2
Query: 329 IVPNIHIRAATIDKLVEELLIHIEQSCESLDDISDDNLVFPKIFFLVHNWFSTSESIGRKL---YNNADI-----KHKSDSSFEDDRILRSNRKFKIGGVTLAFCLWIEFYPNDF--MGSESCMPILTKFIESLQEMGREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAAT------LQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSP-VANKSILFGDFVSGVKPPTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKANHNALKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECRSRGHLYQHNRSSSQSTETNVSFQSLGSPPCSSRQITIDXXXXXXXXXXXXTIVNVETQTSGILSESDMSTLESTSSFEKESNHVCIYSEDDPFDDCDKSHLIETLLRYQKEKNELEIEIKMMQEKFKIQANNIEILQDTVTQLRQKIVKFVLDIMDIFN 2509
+ P I IR ATI +LVE + +++ +D FP++ FL+H WF +SE + +KL Y + D + +S E ++ R+ K + V A WI +P F G ++ F + +Q G L ++ S SYD R +S VR P + S +S SLVF + P +LAEQLT +E+KAFRRIT D K Y++ A++++ P LERS+ +FNGLSQWVQCM+L+KT P +R V++K++ +A L LQNFN+ AV+GG+THSA++R++ T L QK+L +YT ++SSSNN+SNYR+ + KGF IP++ VHLKDLI +TA+PD + NLINFRK AQ AA LQS+ QQL + N+DL N LR SLDL YT++DIYELSLAREP++S+ SP K ++F D+V+G+ PP ++ +HVN MVEAVFK YD D+DG IS EFE +A NFPFIDSF VLDAD+DG+ISK EMK YF++AN +AL+NSFKH F+E TYFKPT+C HCTGLLWGLIKQGW+C+DCGINAHKHCK+ VVMECR + H+ SS S+ ++ + SP T RK + K ++ TQT S +++E + E + +DP + L E L+ ++ +++L E K ++ K + Q++ I L+ + +RQ + F+LD MD +
Sbjct: 43 VSPGIGIRTATIQQLVEATVDSFDENGAVIDSTD-----FPRVLFLMHRWFISSEELAQKLIEVYQSCDSYVICEQTCQHTSSEGNKCRRNQFKAR---VCHAVRYWINNFPVHFDPRGDTKLAAVVHNFEKVIQAEGNNKLKALVDISKVPSYDWMRIIS----VRNPSTRS------HSRKVSLVFQHLQPNELAEQLTFLEYKAFRRITFTDFKNYAVQASLKDNPKLERSIALFNGLSQWVQCMVLSKTTPEQRGHVIQKYVNVARRLRELQNFNTLMAVVGGLTHSALARLSKTNACLIPETQKLLGDYTDLLSSSNNFSNYRKTLYQCKGFRIPILGVHLKDLISLNTAVPDRV--DNLINFRKMAQLAAIFSELTYLQSMQQQQLP---FDTNLDLANMLRCSLDLNYTDDDIYELSLAREPRNSLSSPPTPTKPVVFADWVAGISPPDPVLINKHVNDMVEAVFKNYDLDRDGFISHAEFEDIAGNFPFIDSFCVLDADQDGMISKAEMKTYFVRANCHALRNSFKHAFHETTYFKPTYCVHCTGLLWGLIKQGWKCKDCGINAHKHCKDLVVMECRGKQHM---GSSSRSSSLSSGNGHGTSSPKAYDLTTTSKRKMSHRWRAKHQS-----TQTEECADLSPKNSMEEVNGINNEEFY------EDP------TSLYERLVEAEETRDKLLAENKSLKAKLENQSDQITTLKSHIGLIRQHTITFILDQMDTLH 743
BLAST of Ras guanyl-releasing protein 3 vs. TrEMBL
Match: A0A1S3HM94 (ras guanyl-releasing protein 3 isoform X2 OS=Lingula unguis OX=7574 GN=LOC106156052 PE=4 SV=1) HSP 1 Score: 543.888 bits (1400), Expect = 2.220e-178 Identity = 334/788 (42.39%), Postives = 470/788 (59.64%), Query Frame = 2
Query: 197 IQSVHSEEPTCSLQKCYSADDNMLGTHMSLSNSVDEEIIYEDHCIVPNIHIRAATIDKLVEELLIHIEQSCESLDDISDDNLVFPKIFFLVHNWFSTSESIGRKL---YNNADI-----KHKSDSSFEDDRILRSNRKFKIGGVTLAFCLWIEFYPNDF--MGSESCMPILTKFIESLQEMGREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAAT------LQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSP-VANKSILFGDFVSGVKPPTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKANHNALKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECRSRGHLYQHNRSSSQSTETNVSFQSLGSPPCSSRQITIDXXXXXXXXXXXXTIVNVETQTSGILSESDMSTLESTSSFEKESNHVCIYSEDDPFDDCDKSHLIETLLRYQKEKNELEIEIKMMQEKFKIQANNIEILQDTVTQLRQKIVKFVLDIMDIFN 2509
I +H EP S ++ DN + M LS D+ + P I IR ATI +LVE + +++ +D FP++ FL+H WF +SE + +KL Y + D + +S E ++ R+ K + V A WI +P F G ++ F + +Q G L ++ S SYD R +S VR P + S +S SLVF + P +LAEQLT +E+KAFRRIT D K Y++ A++++ P LERS+ +FNGLSQWVQCM+L+KT P +R V++K++ +A L LQNFN+ AV+GG+THSA++R++ T L QK+L +YT ++SSSNN+SNYR+ + KGF IP++ VHLKDLI +TA+PD + NLINFRK AQ AA LQS+ QQL + N+DL N LR SLDL YT++DIYELSLAREP++S+ SP K ++F D+V+G+ PP ++ +HVN MVEAVFK YD D+DG IS EFE +A NFPFIDSF VLDAD+DG+ISK EMK YF++AN +AL+NSFKH F+E TYFKPT+C HCTGLLWGLIKQGW+C+DCGINAHKHCK+ VVMECR + H+ SS S+ ++ + SP T RK + K ++ TQT S +++E + E + +DP + L E L+ ++ +++L E K ++ K + Q++ I L+ + +RQ + F+LD MD +
Sbjct: 31 ITILHHFEPPMSPKRGQEMFDNRVN-QMRLSCLEDDRPATP---VSPGIGIRTATIQQLVEATVDSFDENGAVIDSTD-----FPRVLFLMHRWFISSEELAQKLIEVYQSCDSYVICEQTCQHTSSEGNKCRRNQFKAR---VCHAVRYWINNFPVHFDPRGDTKLAAVVHNFEKVIQAEGNNKLKALVDISKVPSYDWMRIIS----VRNPSTRS------HSRKVSLVFQHLQPNELAEQLTFLEYKAFRRITFTDFKNYAVQASLKDNPKLERSIALFNGLSQWVQCMVLSKTTPEQRGHVIQKYVNVARRLRELQNFNTLMAVVGGLTHSALARLSKTNACLIPETQKLLGDYTDLLSSSNNFSNYRKTLYQCKGFRIPILGVHLKDLISLNTAVPDRV--DNLINFRKMAQLAAIFSELTYLQSMQQQQLP---FDTNLDLANMLRCSLDLNYTDDDIYELSLAREPRNSLSSPPTPTKPVVFADWVAGISPPDPVLINKHVNDMVEAVFKNYDLDRDGFISHAEFEDIAGNFPFIDSFCVLDADQDGMISKAEMKTYFVRANCHALRNSFKHAFHETTYFKPTYCVHCTGLLWGLIKQGWKCKDCGINAHKHCKDLVVMECRGKQHM---GSSSRSSSLSSGNGHGTSSPKAYDLTTTSKRKMSHRWRAKHQS-----TQTEECADLSPKNSMEEVNGINNEEFY------EDP------TSLYERLVEAEETRDKLLAENKSLKAKLENQSDQITTLKSHIGLIRQHTITFILDQMDTLH 771
BLAST of Ras guanyl-releasing protein 3 vs. TrEMBL
Match: A0A1S3HKQ2 (ras guanyl-releasing protein 3 isoform X1 OS=Lingula unguis OX=7574 GN=LOC106156052 PE=4 SV=1) HSP 1 Score: 545.814 bits (1405), Expect = 5.386e-177 Identity = 340/816 (41.67%), Postives = 477/816 (58.46%), Query Frame = 2
Query: 122 KRTTGKLHERLWPNIKLQKWGKNRRIQSVHSEEPTCSLQKCYSADDNMLGTHMSLSNSVDEEIIYEDHCIVPNIHIRAATIDKLVEELLIHIEQSCESLDDISDDNLVFPKIFFLVHNWFSTSESIGRKL---YNNAD--------IKHKSDSSFEDDRILRSNRKFKIGGVTLAFCLWIEFYPNDF--MGSESCMPILTKFIESLQEMGREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAAT------LQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSP-VANKSILFGDFVSGVKPPTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKANHNALKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECRSRGHLYQHNRSSSQSTETNVSFQSLGSPPCSSRQITIDXXXXXXXXXXXXTIVNVETQTSGILSESDMSTLESTSSFEKESNHVCIYSEDDPFDDCDKSHLIETLLRYQKEKNELEIEIKMMQEKFKIQANNIEILQDTVTQLRQKIVKFVLDIMDIFN 2509
K GK R P I++Q EP S ++ DN + M LS D+ + P I IR ATI +LVE + +++ +D FP++ FL+H WF +SE + +KL Y + D +H +S E ++ R+ K + V A WI +P F G ++ F + +Q G L ++ S SYD R +S VR P + S +S SLVF + P +LAEQLT +E+KAFRRIT D K Y++ A++++ P LERS+ +FNGLSQWVQCM+L+KT P +R V++K++ +A L LQNFN+ AV+GG+THSA++R++ T L QK+L +YT ++SSSNN+SNYR+ + KGF IP++ VHLKDLI +TA+PD + NLINFRK AQ AA LQS+ QQL + N+DL N LR SLDL YT++DIYELSLAREP++S+ SP K ++F D+V+G+ PP ++ +HVN MVEAVFK YD D+DG IS EFE +A NFPFIDSF VLDAD+DG+ISK EMK YF++AN +AL+NSFKH F+E TYFKPT+C HCTGLLWGLIKQGW+C+DCGINAHKHCK+ VVMECR + H+ SS S+ ++ + SP T RK + K ++ TQT S +++E + E + +DP + L E L+ ++ +++L E K ++ K + Q++ I L+ + +RQ + F+LD MD +
Sbjct: 180 KEKGGKREARKKPEIRIQ------------LTEPPMSPKRGQEMFDNRVN-QMRLSCLEDDRPATP---VSPGIGIRTATIQQLVEATVDSFDENGAVIDSTD-----FPRVLFLMHRWFISSEELAQKLIEVYQSCDSYVICEQTCQH---TSSEGNKCRRNQFKAR---VCHAVRYWINNFPVHFDPRGDTKLAAVVHNFEKVIQAEGNNKLKALVDISKVPSYDWMRIIS----VRNPSTRS------HSRKVSLVFQHLQPNELAEQLTFLEYKAFRRITFTDFKNYAVQASLKDNPKLERSIALFNGLSQWVQCMVLSKTTPEQRGHVIQKYVNVARRLRELQNFNTLMAVVGGLTHSALARLSKTNACLIPETQKLLGDYTDLLSSSNNFSNYRKTLYQCKGFRIPILGVHLKDLISLNTAVPDRV--DNLINFRKMAQLAAIFSELTYLQSMQQQQLP---FDTNLDLANMLRCSLDLNYTDDDIYELSLAREPRNSLSSPPTPTKPVVFADWVAGISPPDPVLINKHVNDMVEAVFKNYDLDRDGFISHAEFEDIAGNFPFIDSFCVLDADQDGMISKAEMKTYFVRANCHALRNSFKHAFHETTYFKPTYCVHCTGLLWGLIKQGWKCKDCGINAHKHCKDLVVMECRGKQHM---GSSSRSSSLSSGNGHGTSSPKAYDLTTTSKRKMSHRWRAKHQS-----TQTEECADLSPKNSMEEVNGINNEEFY------EDP------TSLYERLVEAEETRDKLLAENKSLKAKLENQSDQITTLKSHIGLIRQHTITFILDQMDTLH 933
BLAST of Ras guanyl-releasing protein 3 vs. TrEMBL
Match: A0A2T7NW84 (Uncharacterized protein OS=Pomacea canaliculata OX=400727 GN=C0Q70_13068 PE=4 SV=1) HSP 1 Score: 537.724 bits (1384), Expect = 1.112e-176 Identity = 317/737 (43.01%), Postives = 457/737 (62.01%), Query Frame = 2
Query: 335 PNIHIRAATIDKLVEELLIHIEQSCESLDDISDDNLVFPKIFFLVHNWFSTSESIGRK---LYNNADIKHKSD-------SSFEDDRILRSNRKFKIGGVTLAFCLWIEFYPNDFMGSESCMPILTKFIESLQEMGREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILD-QQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSPVA-NKSILFGDFVSGVKPPTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKANHNALKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECRSRGHLYQHNRSSSQSTETNVSFQSLGSPPCSSRQITIDXXXXXXXXXXXXTIVNVETQTSGILSESDMSTLESTSSFEKESNHVCIYSEDDPFDDCDKSHLIETLLRYQKEKNELEIEIKMMQEKFKIQANNIEILQDTVTQLRQKIVKFVLDIMDIFN 2509
P I IRAAT ++L+E + E+ ++ F K+FFL+H WF TSE + + LY ++D D S D ++ RK + A WI YP F + + LQ G L L+ S SY+ R +S+R + S +S SLVFN + P +LA QLT +E+KAFRRI D K Y++TA++++ P LERS+ +FNGLSQWVQCM+L KT P +RA V+ KF+ ++++L VLQNFN+ A++GG++HSA++R++ T+ L +QK+L E+T+++SS+NN+SNYR++ GF IP++ VHLKDLI HTALPD L+NFRK AQ ++ L+ + Q + ++ N+DL NTLRLSLDL YTE++IYELS AREP+ S+ SP K ++F D+V+GV PP + + +HV+ MVEAVFK YD+D+DG IS EFE +A NFPFIDSF VLDAD+DG+ISK EMK YF++AN +AL+NSFKH F+E TYF+PTFC HCTGLLWGLIKQGW+C+DCGINAHKHCK+ VVMECRS+G ST+ S + P ++T+ KRK+SQ++K+ + +++ Q++ D+ S SS + V + D F + ++S L E LL+ ++++ +L E M++ + +I I L+ + +RQ + F+L+ MD +
Sbjct: 21 PGITIRAATPERLIELCVGAFEEG------VAVQQEDFVKVFFLMHQWFMTSEELVQAFIDLYQSSDETVSCDHPGCRHLPSCHDCQVQHYKRK-----ICQAVRYWITNYPMHFDLNGHVTAAVQSLGGLLQAEGNSQLKELLDLSTVPSYEWMRSMSVRNT-----------GSKHSRKVSLVFNHLEPEELASQLTYLEYKAFRRIHFVDFKNYAMTASLKDQPKLERSIALFNGLSQWVQCMVLCKTTPQQRADVIVKFINVSKHLRVLQNFNTLMAIVGGLSHSALARLSKTISCLPSESQKILMEFTELLSSNNNFSNYRKVYHACTGFKIPILGVHLKDLISLHTALPDRAEG-GLLNFRKMAQLSSILRELTRLQGHDSVPVDANMDLVNTLRLSLDLHYTEDEIYELSQAREPRESLSSPTTPTKPVVFADWVAGVSPPDSNTINKHVHDMVEAVFKNYDHDRDGFISHGEFEAIAGNFPFIDSFCVLDADQDGMISKVEMKTYFIRANCHALRNSFKHAFHETTYFRPTFCIHCTGLLWGLIKQGWKCKDCGINAHKHCKDLVVMECRSKG-----------STKRTESLSNGAGMP----EMTLSAKRKISQRQKRASPSHLQEQSA---QTEDVIHRMSCSSRCQPHREVTLV--DGEFYE-EQSLLYERLLKAEEDREKLMEENSMLRSRLEIANEQIMTLKSHIGVIRQNTIAFILEQMDALH 713
BLAST of Ras guanyl-releasing protein 3 vs. TrEMBL
Match: A0A2C9LQT2 (Uncharacterized protein OS=Biomphalaria glabrata OX=6526 GN=106080248 PE=4 SV=1) HSP 1 Score: 530.02 bits (1364), Expect = 7.490e-173 Identity = 309/738 (41.87%), Postives = 448/738 (60.70%), Query Frame = 2
Query: 347 IRAATIDKLVEELLIHIEQSCESLDDISDDNLVFPKIFFLVHNWFSTSESIGRKLYNNADIKHKSDSSFEDDRILRSNRKFKIGG--------VTLAFCLWIEFYPNDFMGSESCMPILTKFIESLQEMGREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILD-QQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSPVA-NKSILFGDFVSGVKPPTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKANHNALKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECRSRGHLYQHNRSSSQSTETNVSFQSLGSPP-----CSSRQITIDXXXXXXXXXXXXTIVNVETQTSG-ILSESDMSTLESTSSFEKESNHV-CIYSEDDPFDDCDKSHLIETLLRYQKEKNELEIEIKMMQEKFKIQANNIEILQDTVTQLRQKIVKFVLDIMDIFN 2509
+RAAT ++L++ + +E E ++ ++ F +FFL+H WF TSE + + D+ D + + + G + A WI +P F + + LQ G L ++ S SYD R +S+R + +S SLVFN + P LA QLT +E+KAFRR+ D K Y+LTA++++ P LERS+ +FNGLSQWVQCM+L+KT P +RA V+ KF+ ++++L VLQNFN+ A++GG++HSA++R++ T+ L +QK L + T ++SS+NN+SNYR++ + GF IP++ VHLKDLI HTALPD + NL+NFRK AQ A L+ + Q L + I+ N+DL NTLRLSLDL +TE++IYELSLAREP+ S+ SP K ++F D++ G+ PP D + +HV+ MVEAVFK YD DKDG IS EEF+ +A NFPFIDSF VLDADKDG+ISK EMK YF++AN + L+NSFKH F+E TYFKPTFC HCTGLLWGLIKQGW+C+DCGINAH+HCK+QVVMECRS+G + R+ S S G P + R+I+ ++ ++ TQT G +L S S+L+ +S NH C + + ++ +++ L E LL+ ++ + +L E ++ K I + I +L+ + +RQ + F+L+ MD +
Sbjct: 83 VRAATPERLIQ---MCVESFTEK--ELDKNHEEFVNVFFLMHPWFMTSEELAQAFI---DLYQGCDETVTCTMVACQHLPINTGCAIQTYKKMICQAVRYWICKFPLHFDMDTLVTTAVKRLSSLLQAEGNYRLKELVDVSKVPSYDWMRNMSVRSTTH----------GKHSRKVSLVFNHLEPKDLATQLTYLEYKAFRRVHFSDYKNYALTASLKDQPKLERSIALFNGLSQWVQCMVLSKTTPQQRADVICKFIDVSKHLRVLQNFNTLMAIVGGLSHSALARLSKTIACLPAESQKTLMDLTDLLSSNNNFSNYRKVYHQCTGFKIPILGVHLKDLISLHTALPDRVEG-NLLNFRKMAQLAIILKELTRLQGLDSIPIDANMDLVNTLRLSLDLYHTEDEIYELSLAREPRGSLSSPTTPTKPVVFADWLLGLSPPDSDTINKHVHDMVEAVFKNYDLDKDGFISHEEFDSIAGNFPFIDSFCVLDADKDGMISKREMKTYFIRANSHVLRNSFKHAFHETTYFKPTFCIHCTGLLWGLIKQGWKCKDCGINAHRHCKDQVVMECRSKG----NKRTESMSN---------GKGPHDLTITAKRKIS----QRHLKRSSPSHTCQQSTQTEGAVLRRS--SSLKVMNSSNSHRNHRDCTLLDGEYYE--EQALLYERLLKAEEAREKLLEENSRLRSKLDIANDQISLLKSHIGIIRQNTIAFILEQMDALH 780
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Cavefish
Match: rasgrp3 (RAS guanyl releasing protein 3 (calcium and DAG-regulated) [Source:ZFIN;Acc:ZDB-GENE-070424-82]) HSP 1 Score: 387.882 bits (995), Expect = 2.876e-122 Identity = 213/537 (39.66%), Postives = 313/537 (58.29%), Query Frame = 2
Query: 446 FPKIFFLVHNWFSTSESIGRKLYNNADIKHKSDSSFEDDRILRSNRKFKIGGVTLAFCLWIEFYPNDFMGSESCMPILTKFIESLQEMGREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSPVA----NKSILFGDFVSGV-KPPTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKAN---HNALKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECR 2032
P+ L+H W+ +S + KL + + + ++R WI+ +P +F + + +F + ++G + + L+ S SYD R L+ R ++ V SL+F+ + P++LAE LT +E+K+ RRI+ D + Y + + + PTLERS+ +FNG+SQWVQ M+L+K P RA V+ KF+ +A+ LL LQNFN+ AV+GG++HS+ISR+ T LS K+ E T+++SS+ NY YR+ E +GF IP++ VHLKDLI H PD + + +N K Q T ++ Q T +E N+DL L LSLD+ YTE++IYELSL REP++ P + NK+ D+ SGV P V+ +H+ +V++VF+ YD+D DG IS E+FE +A NFPF+DSF VLD D+DG+ISK EM YFL+AN + F H F E Y KPTFC HCTG LWG+IKQG++C+DCG+N HK C+E +V+ CR
Sbjct: 34 LPRTLLLMHRWYVSSTELAGKLLMIYPLPALCRTRLKICYLMR---------------YWIDEFPAEFDLDLGLIRLTEEFRDVAAQLGCDQHLKLLDISTIPSYDWMRKLTQR---KKQVKKG---------KASLLFDHLEPIELAEHLTFLEYKSIRRISFTDYQSYVVHGCLVDNPTLERSIALFNGVSQWVQLMVLSKLTPQHRANVISKFIHVAQKLLHLQNFNTLMAVVGGLSHSSISRLKETHSHLSPDVTKIWSEMTELVSSNGNYCAYRKAYSECEGFKIPILGVHLKDLIAVHVVFPDWVEDSK-VNIVKMQQLYLTFSELVALQSTAAQVEPNMDLIYLLTLSLDIYYTEDEIYELSLLREPRNPKSLPTSPTTPNKTQAPLDWASGVTTKPDPSVVNKHIRKVVDSVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRANPVLQCKMGPGFIHNFQEMNYLKPTFCEHCTGFLWGIIKQGYKCKDCGVNCHKQCRELLVLACR 542
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Cavefish
Match: RASGRP1 (RAS guanyl releasing protein 1 [Source:HGNC Symbol;Acc:HGNC:9878]) HSP 1 Score: 360.147 bits (923), Expect = 1.681e-112 Identity = 215/563 (38.19%), Postives = 313/563 (55.60%), Query Frame = 2
Query: 608 LAFCLWIEFYPNDFMGS---ESCMP-ILTKFIESLQEMGREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSPV-ANKSILFGDFVSGVKP-PTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKAN--HNALKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECRSRGHLYQHNRSSSQSTETNVSFQSLG--------------SPPCSSRQITIDXXXXXXXXXXXXTIVNVETQTSGILSES 2230
L C +I ++ ++F SC+ + +F + ++E G+E L L+ + SR S ++ ASS SL+F+ + P++LAE LT +EFK+F RI+ D + Y + IP +ERS+ + NG+SQWVQ M+L++ RA+V KF+ +A+NL +QNFN+ AV+GG+ HS+ISR+ T + K+L E T ++SS NY NYRQ+ + GF IP++ VHLKDLI + A+ D+L N + IN +K + ++ QQ ++ N DL + L LSLDL YTE++IYELS AREP++ P ++ + D+ SGV P P + +HV MV++VF YD+D G IS E+FE +A +FPF SF V+D DKDG+IS+ E+ YF++A+ + L F H F E TY +PTFC +C+G LWG+IKQG+RCRDCG+N HK CK+QV EC N S S+ T S G PP + Q ++VN TQT L+ S
Sbjct: 19 LKMCYFIRYWISEFWSMFRLHSCLSESVEQFKDLMREHGQEQLCPLLQTKWMGDREWSRKASQKIK-----------ASSKKRKVSLLFDHLEPVELAEHLTYLEFKSFCRISFSDYQKYIRNECLTEIPAMERSIALCNGISQWVQLMVLSRPTAQLRAEVFTKFIYVAQNLQQMQNFNTLMAVVGGLCHSSISRLKDTCTYVPNETTKVLNEMTDLLSSCRNYENYRQMYSKCSGFKIPILGVHLKDLIAVNEAMTDYLEN-DKINVQKLQALYNHINELVQQQQNPPLLDANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRAPPATPHRPPVVVDWASGVAPKPDPKTISKHVQRMVDSVFTNYDHDGRGFISQEDFEKIAASFPF--SFCVMDKDKDGLISREEITAYFMRASVICSKLGLGFSHNFQEMTYMRPTFCDNCSGFLWGVIKQGYRCRDCGMNCHKSCKDQVAFECNKNAKT-SGNPDWSPSSNTADSAAPGGHDGPDEAQFIYTGDPPPDCTNQPNPASYSNQLTVASGTSLVNRSTQTEAALTPS 566
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Cavefish
Match: ENSAMXT00000038621.1 (RAS guanyl-releasing protein 2-like [Source:NCBI gene;Acc:103046990]) HSP 1 Score: 338.191 bits (866), Expect = 4.677e-105 Identity = 207/613 (33.77%), Postives = 323/613 (52.69%), Query Frame = 2
Query: 338 NIHIRAATIDKLVEELLIHIEQSCESLDDISDDNLVFPKIFFLVHNWFSTSESIGRKLYNNADIKHKSDSSFEDDRILRSNRKFKIGGVTLAFCLWIEFYPNDFMGSESCMPILTKFIESLQEM----GREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHL-YNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSS---------IDSPVANKSILFGDFVSGVKPPT-VDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKANHNA-LKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECRSRGHLYQHNRSSSQSTETNVSFQSLGSPPCSS 2128
++ + +AT+D+LV+ + Q+ + + D ++V ++F ++H W+ S + +KL +L+S + + C ++++ +F + P L + I L+E G E ++ SY R ++ R+ + S SL+F + +LAE LT +E+K+F +I QD + + P LER + +FN +SQW+Q M+L+K +RA VV F+ +A+ LL LQNFN+ AV+GG+++S+ISR+ T +S K+ ++++S NYS YR+ + GF P++ VHLKDLI H ALPD + +N K Q A LQ + Q T E N DL N L +SLD +TE++IY+LSL REP+S+ SP A + + ++ + VKP ++ +H+ MV++VFK +D D DG IS EEFE + NFP++ F LD ++DG IS+ EM YF+KA+ K F H F E TY KPTFC HC G +WG KQG++C+ CG+N HK C+ ++ MECR R +S S T + +S PP S+
Sbjct: 3 SLQMESATVDELVDACI----QAFDDTGKLKDSSVV--RMFLMMHPWYLPSTDLAKKL------------------LLKSQEEACTAELRSRICHLVKYWIAEFPVEFNLNPALAEQIRDLREQLNTEGNERDSQLIDVESVPSYKWKRQVTQRIP-----------SVSKKRKMSLLFEHLDASELAEHLTYLEYKSFCKILFQDYHSFVRHGCTVDNPILERFITLFNSVSQWIQLMVLSKPTAQQRAAVVTHFIRVAQKLLQLQNFNTLMAVVGGLSNSSISRLKDTQTHISNDTNKIFNSLIELVTSCGNYSQYRRRFADCSGFRFPILGVHLKDLIAVHVALPDWTNPEKTRVNLAKTQQLYAILQELALVQTTPPNTEANTDLLNLLTVSLDQYHTEDEIYQLSLQREPRSTKPAGQNSSPTPSPSAKRPSMIDEWAASVKPKADPAIITKHIEKMVDSVFKNFDTDGDGHISREEFESIRNNFPYLSKFGELDTNQDGKISREEMIDYFMKASSLLNCKMGFIHTFSETTYVKPTFCEHCAGFIWGFYKQGYKCKVCGVNCHKACRSRLAMECRKR------TKSISHETPPALQARSYSFPPPSN 574
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Cavefish
Match: ENSAMXT00000021558.2 (RAS guanyl-releasing protein 2-like [Source:NCBI gene;Acc:103046990]) HSP 1 Score: 331.643 bits (849), Expect = 9.524e-103 Identity = 205/612 (33.50%), Postives = 315/612 (51.47%), Query Frame = 2
Query: 338 NIHIRAATIDKLVEELLIHIEQSCESLDDISDDNLVFPKIFFLVHNWFSTSESIGRKLYNNADIKHKSDSSFEDDRILRSNRKFKIGGVTLAFCL------------WIEFYPNDFMGSESCMPILTKFIESLQEMGREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHL-YNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSPVANKSILFGDFVSGVKPPT-VDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKANHNA-LKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECRSRGHLYQHNRSSSQSTETNVSFQSLGSPPCSS 2128
++ + +AT+D+LV+ + Q+ + + D ++V ++F ++H W+ S + +KL K V +C+ WI +P +F + + + E L G E ++ SY R ++ R+ + S SL+F + +LAE LT +E+K+F +I QD + + P LER + +FN +SQW+Q M+L+K +RA VV F+ +A+ LL LQNFN+ AV+GG+++S+ISR+ T +S K+ ++++S NYS YR+ + GF P++ VHLKDLI H ALPD + +N K Q A LQ + Q T E N DL N L +SLD +TE++IY+LSL REP+S+ P + ++ + VKP ++ +H+ MV++VFK +D D DG IS EEFE + NFP++ F LD ++DG IS+ EM YF+KA+ K F H F E TY KPTFC HC G +WG KQG++C+ CG+N HK C+ ++ MECR R +S S T + +S PP S+
Sbjct: 3 SLQMESATVDELVDACI----QAFDDTGKLKDSSVV--RMFLMMHPWYLPSTDLAKKLL------------------------LKYPFVIHTYCICTKTVNETERKYWIAEFPVEFNLNPALAEQIRDLREQLNTEGNERDSQLIDVESVPSYKWKRQVTQRIP-----------SVSKKRKMSLLFEHLDASELAEHLTYLEYKSFCKILFQDYHSFVRHGCTVDNPILERFITLFNSVSQWIQLMVLSKPTAQQRAAVVTHFIRVAQKLLQLQNFNTLMAVVGGLSNSSISRLKDTQTHISNDTNKIFNSLIELVTSCGNYSQYRRRFADCSGFRFPILGVHLKDLIAVHVALPDWTNPEKTRVNLAKTQQLYAILQELALVQTTPPNTEANTDLLNLLTVSLDQYHTEDEIYQLSLQREPRSTKPRPS-----MIDEWAASVKPKADPAIITKHIEKMVDSVFKNFDTDGDGHISREEFESIRNNFPYLSKFGELDTNQDGKISREEMIDYFMKASSLLNCKMGFIHTFSETTYVKPTFCEHCAGFIWGFYKQGYKCKVCGVNCHKACRSRLAMECRKR------TKSISHETPPALQARSYSFPPPSN 562
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Cavefish
Match: RASGRP1 (RAS guanyl releasing protein 1 [Source:HGNC Symbol;Acc:HGNC:9878]) HSP 1 Score: 328.561 bits (841), Expect = 5.593e-101 Identity = 189/480 (39.38%), Postives = 274/480 (57.08%), Query Frame = 2
Query: 608 LAFCLWIEFYPNDFMGS---ESCMP-ILTKFIESLQEMGREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSPVANKSILFGDFVSGVKPPTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKAN--HNALKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMEC 2029
L C +I ++ ++F SC+ + +F + ++E G+E L L+ + SR S ++ ASS SL+F+ + P++LAE LT +EFK+F RI+ D + Y + IP +ERS+ + NG+SQWVQ M+L++ RA+V KF+ +A+NL +QNFN+ AV+GG+ HS+ISR+ T + K+L E T ++SS NY NYRQ+ + GF IP++ VHLKDLI + A+ D+L N + IN +K + ++ QQ ++ N DL + L LSLDL YTE++IYELS AREP+ N +VF YD+D G IS E+FE +A +FPF SF V+D DKDG+IS+ E+ YF++A+ + L F H F E TY +PTFC +C+G LWG+IKQG+RCRDCG+N HK CK+QV EC
Sbjct: 83 LKMCYFIRYWISEFWSMFRLHSCLSESVEQFKDLMREHGQEQLCPLLQTKWMGDREWSRKASQKIK-----------ASSKKRKVSLLFDHLEPVELAEHLTYLEFKSFCRISFSDYQKYIRNECLTEIPAMERSIALCNGISQWVQLMVLSRPTAQLRAEVFTKFIYVAQNLQQMQNFNTLMAVVGGLCHSSISRLKDTCTYVPNETTKVLNEMTDLLSSCRNYENYRQMYSKCSGFKIPILGVHLKDLIAVNEAMTDYLEN-DKINVQKLQALYNHINELVQQQQNPPLLDANKDLVHLLTLSLDLYYTEDEIYELSYAREPR---------------------------------NHRAPSVFTNYDHDGRGFISQEDFEKIAASFPF--SFCVMDKDKDGLISREEITAYFMRASVICSKLGLGFSHNFQEMTYMRPTFCDNCSGFLWGVIKQGYRCRDCGMNCHKSCKDQVAFEC 515
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002458.1 (pep scaffold:Pmarinus_7.0:GL479588:3:23579:-1 gene:ENSPMAG00000002237.1 transcript:ENSPMAT00000002458.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 64.3142 bits (155), Expect = 1.227e-11 Identity = 28/60 (46.67%), Postives = 35/60 (58.33%), Query Frame = 2
Query: 1862 LKNSFK----HEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMEC 2029
+K FK H F N+Y PTFC HC LLWGL +QG +C +C +N H CK +V C
Sbjct: 180 MKERFKLDVPHRFRVNSYMSPTFCDHCGTLLWGLARQGLKCDECAMNIHHKCKGKVANMC 239
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002460.1 (pep scaffold:Pmarinus_7.0:GL479588:3:23579:-1 gene:ENSPMAG00000002237.1 transcript:ENSPMAT00000002460.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 64.3142 bits (155), Expect = 1.404e-11 Identity = 28/60 (46.67%), Postives = 35/60 (58.33%), Query Frame = 2
Query: 1862 LKNSFK----HEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMEC 2029
+K FK H F N+Y PTFC HC LLWGL +QG +C +C +N H CK +V C
Sbjct: 179 MKERFKLDVPHRFRVNSYMSPTFCDHCGTLLWGLARQGLKCDECAMNIHHKCKGKVANMC 238
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005082.1 (pep scaffold:Pmarinus_7.0:GL478314:141397:156611:1 gene:ENSPMAG00000004611.1 transcript:ENSPMAT00000005082.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 65.855 bits (159), Expect = 2.408e-11 Identity = 57/200 (28.50%), Postives = 100/200 (50.00%), Query Frame = 2
Query: 878 LKLAEQLTVIEFKAFRRIT----IQDL-KLYSLTATVRNIPTLERSVYIFNG-LSQ---WVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQL--QKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSIL 1444
+++A Q+++ +F FR I + DL KL S T T R++ +F G L+Q WV +L + +R KV++ F+ IA + +NFNS +A+I G++HS+++R+N T L + + E + S N + YR + + + IP+ V KDL F H + ++NF K A ++ ++
Sbjct: 1 VEVAAQVSMGDFDLFRTIEPTEYVDDLFKLRSRTGT--------RALKLFEGALNQETFWVASEVLAEPGQIKRVKVLKHFIKIALHCRECKNFNSMFAIISGLSHSSVARLNGTWEKLPTKYESLYRELQDLFDPSRNMAKYRNVLSSQSLQPPLIPLFPVVKKDLTFLHEGNDSRVD--GMVNFEKLRMIAKEVRQVV 190
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004337.1 (pep scaffold:Pmarinus_7.0:GL478852:175856:252872:1 gene:ENSPMAG00000003926.1 transcript:ENSPMAT00000004337.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 64.3142 bits (155), Expect = 8.907e-11 Identity = 30/95 (31.58%), Postives = 47/95 (49.47%), Query Frame = 2
Query: 1823 EMKMYFLKANHNAL----KNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECRSRGHLYQHNRSSSQSTETNVS 2095
E+KM+ K AL + H F T PT+C C GLLWG+ +QG RC +CG+ H+ C++ + +C R + T+T ++
Sbjct: 50 ELKMHVYKKTLQALIYPISCTIPHRFEVWTATAPTYCYECEGLLWGIARQGMRCTECGVKCHEKCQDLLNADCLQRAAEKSSKHGAEDKTQTIIT 144
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Sea Lamprey
Match: PRKCE (protein kinase C epsilon [Source:HGNC Symbol;Acc:HGNC:9401]) HSP 1 Score: 62.3882 bits (150), Expect = 1.662e-10 Identity = 23/50 (46.00%), Postives = 33/50 (66.00%), Query Frame = 2
Query: 1880 HEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMEC 2029
H+F + Y PTFC HC LLWGL++QG +C+ C +N H+ C++ V C
Sbjct: 34 HKFSIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCEQNVAPSC 83
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Yeast
Match: CDC25 (Membrane bound guanine nucleotide exchange factor; also known as a GEF or GDP-release factor; indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1; thermosensitivity of the cdc25-5 mutant is functionally complemented by human RASGRF1 or by a fragment of human SOS1 comprising the CDC25-related catalytic domain [Source:SGD;Acc:S000004301]) HSP 1 Score: 78.9518 bits (193), Expect = 2.435e-15 Identity = 65/240 (27.08%), Postives = 116/240 (48.33%), Query Frame = 2
Query: 869 IHPLKLAEQLTVIEFKAFRRITI---QDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFH-IPVVAVHLKDLIFYHTALPDHLYNR-NLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKS 1573
I P A QLTV+E + RIT+ D + + P + + + N L+ +V I+ + R+K+ + F+ +A++ L NF+S A++ + S I R+ T +S ++ +L+ ++ S N+ YR+L + +P V+L DL F PD L+N N+INF K + A ++ I+ + +++ D+ + SL+ E Y+LSL EP+S
Sbjct: 1304 IDPYTYATQLTVLEHDLYLRITMFECLDRAWGTKYCNMGGSPNITKFIANANTLTNFVSHTIVKQADVKTRSKLTQYFVTVAQHCKELNNFSSMTAIVSALYSSPIYRLKKTWDLVSTESKDLLKNLNNLMDSKRNFVKYRELLRSVTDVACVPFFGVYLSDLTFTFVGNPDFLHNSTNIINFSKRTKIANIVEEIISFKRFHYKLKRLDDIQTVIEASLENVPHIEKQYQLSLQVEPRS 1543
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Nematostella
Match: EDO42184 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S271]) HSP 1 Score: 367.466 bits (942), Expect = 6.665e-119 Identity = 193/399 (48.37%), Postives = 264/399 (66.17%), Query Frame = 2
Query: 851 SLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKS--SIDSPVANKSILFGDFVSG-VKPPTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKANHNALKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECRSR 2038
SL F P ++AEQLT +EF+ RRI D K YSLT+ + N LER V +FNGLS+W+Q M+LN T+ +RAK +EKF +A++L LQNFN AV GG+ +S +SR+ T +S ++ + T+ +SS NNY+ YR+ GF+IP++ + LKDLI HTAL D + N LIN K A + + Q T + N++L N LR+SL + +E+++YELSLAREP++ S+ V+N S +F D+ SG P V+++HV+ MVEAVF+VYD +KDG ISS+EF+ +A NFPFID FAV+D++ DG+I+K EM YFLK N L F H F E TYF PT+C HC GLL G+IKQG RCRDC IN HK CK+++V+ECR+R
Sbjct: 3 SLAFQDQQPEEIAEQLTYLEFRMLRRIPFSDWKAYSLTSKLENTTYLERYVSMFNGLSKWIQAMVLNHTSAEDRAKCIEKFQKVAQSLKELQNFNGLLAVTGGLNNSVLSRLLQTREYVSKDCKEYMNLLTEFLSSENNYATYRKRLSCCAGFYIPILRIQLKDLIATHTALSDTV-NDKLINVHKLVTLAGIISKSIVCQTTPPLVTPNMELLNMLRVSLQPRLSEDELYELSLAREPRTMNSVKRKVSNNSNVFADWASGGTAVPDRRVVERHVSAMVEAVFRVYDTNKDGTISSKEFDAIATNFPFIDPFAVIDSNCDGMITKDEMNSYFLKVNCQNLTREFSHNFQETTYFSPTYCDHCGGLLRGIIKQGCRCRDCHINCHKSCKKELVIECRNR 400
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Nematostella
Match: EDO39513 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SA05]) HSP 1 Score: 88.5817 bits (218), Expect = 1.676e-18 Identity = 81/273 (29.67%), Postives = 129/273 (47.25%), Query Frame = 2
Query: 758 YDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSS 1576
Y R R +S M + P S + +++FN H LAEQLT+I+ + F I I ++ + + N P L FN +S W + IL+ P +R K KFL I ++L NFNSF A++ + SA+ R++ L L EYT++I SS+++ YR EA+ IP + + L+D+ F D L + +NF K Q L ++ +L Q E N ++ + E+D++E SL +P+S
Sbjct: 180 YKRDRSISSPMPPQTPTSFN----------PAVIFN-FHAHHLAEQLTLIDAQNFAAIEIPEILAWGKEQSEGNSPNLTVFTENFNKVSYWSRSYILSFEKPQDREKAYLKFLKIMKHLRRFNNFNSFLAILSAMDCSAVRRLDWPKHYLD-----QLAEYTELIDSSSSFRAYRAALAEAQPPCIPYLGLILQDVTFVCLGNADELADGK-VNFVKRWQLFNILDTVRRFKLVQYEFEANEEIRQFFG-GFNNYLNEDDLFEKSLILKPRSG 434
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Nematostella
Match: EDO32740 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SU64]) HSP 1 Score: 70.4774 bits (171), Expect = 1.511e-12 Identity = 71/262 (27.10%), Postives = 118/262 (45.04%), Query Frame = 2
Query: 851 SLVFN--QIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNI--PTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALP-----DHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQ-YTEEDIYELSLAREPKSSIDSPVANKSI 1606
++VF+ ++ P A QLT ++ F+ I ++ T +++ P + FN +S WV ILN R V+ F+ IA+ L + N +S AVI G+ + + R+N T LS + E+ ++S N R + IP + ++L DL++ T P D+ R + + + A QS D TQ I++ +D N + +LQ + E++ Y LSL EPKS S A +
Sbjct: 55 AVVFDITKVTPDNFARQLTYMDLAVFKSIQPEEFSSCGWTKKNKSVQSPNVVALTKRFNHVSFWVVREILNAKKLKTRVAVMSHFIRIAKRLYEMNNLHSLKAVIAGLQSAPVYRLNQTWEQLSRRDHTIFEKLEDLLSEDQNRKRLRDHLNSTRLPCIPHLGMYLTDLMYIDTIHPNTGGLDNERTRKMNDIIRII--AEFQQSHYDCLETQPHIQKYLDSMNYIE---ELQKFLEDNNYRLSLQIEPKSVKSSGEATSGV 311
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Nematostella
Match: EDO42176 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S254]) HSP 1 Score: 65.4698 bits (158), Expect = 4.698e-11 Identity = 24/51 (47.06%), Postives = 31/51 (60.78%), Query Frame = 2
Query: 1880 HEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECR 2032
H F NT+ P +C HC LWGL QG +C+DCG NAHK C + + C+
Sbjct: 193 HNFKTNTFKGPHWCDHCRNFLWGLTMQGVKCQDCGFNAHKQCTKAIPNNCK 243
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Nematostella
Match: EDO26719 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7TB94]) HSP 1 Score: 57.3806 bits (137), Expect = 9.429e-11 Identity = 23/47 (48.94%), Postives = 31/47 (65.96%), Query Frame = 2
Query: 1877 KHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQV 2017
KHEF E+ + KP FC +C LL G IKQG +C++C + H C+E V
Sbjct: 11 KHEFVEHNFRKPQFCYYCNKLLKGFIKQGVKCKNCKMGVHHKCQENV 57
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Medaka
Match: rasgrp3 (RAS guanyl releasing protein 3 [Source:NCBI gene;Acc:105353619]) HSP 1 Score: 396.741 bits (1018), Expect = 5.068e-126 Identity = 226/574 (39.37%), Postives = 328/574 (57.14%), Query Frame = 2
Query: 350 RAATIDKLVEELLIHIEQSCESLDDISDDNL-VFPKIFFLVHNWFSTSESIGRKLYNNADIKHKSDSSFEDDRILRSNRKFKIGGVTLAFCL----WIEFYPNDFMGSESCMPILTKFIESLQEMGREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSPVANKSILFG----DFVSGV-KPPTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKAN---HNALKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECR 2032
+AA+ID L+ E + + DD ++ ++ + P+ L+H W+ S + KL ++ + G L C WI +P +F + I +F + +G E ++ S SYD R L+ R + SL+F+ + P++LAE LT +EFK RRI+ D + Y + + N PTLERS+ +FNG+SQWVQ M+L+K P RA+V+ K++ +A+ LL+LQNFN+ AV+GG++HS+ISR+ T L+ K+ E T+++SSSNNYS YR+ E +GF IP++ VHLKDLI H PD + + N IN K Q T ++ Q +E N+DL + L LSLDL YTE++IYELSL REP++ P + + D+ SGV P V+ +H+ +V++VF+ YD+D DG IS E+FE +A NFPF+DSF VLD D+DG+ISK EM YFL+AN + + F H F E TY KPTFC HC G LWG+IKQG++C+DCG+N HK C+E +V+ CR
Sbjct: 8 KAASIDSLLNECI-------HAFDDSAELHVNLLPRTLLLMHRWYVPSAELAGKLL-----------------MIYPTWQTHGGSTRLRICYLMRYWIVTFPAEFTLDLGLIRITEEFRDVAARLGCEKHFELIDISTIPSYDWMRKLTQRKK------------QTKKGKASLLFDHLEPMELAEHLTFLEFKFIRRISFTDYQSYVIHGCLVNNPTLERSIALFNGVSQWVQLMVLSKLTPQTRAEVISKYIHVAQKLLLLQNFNTLMAVVGGLSHSSISRLKETHSHLAPDVLKIWSEMTELVSSSNNYSCYRKAFNECRGFKIPILGVHLKDLIAVHVVFPDWVGDSNKINLVKMHQLYMTFNELVSLQGAVAHVEPNMDLIHLLTLSLDLYYTEDEIYELSLLREPRNPKSQPTSPTTPTKPSAPLDWASGVTTKPDPSVINKHIRKVVDSVFRNYDHDHDGYISQEDFENIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRANPLLQSKMGPGFIHNFQEMTYLKPTFCDHCAGFLWGIIKQGYKCKDCGVNCHKQCRELLVLACR 545
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Medaka
Match: RASGRP2 (RAS guanyl releasing protein 2 [Source:NCBI gene;Acc:101160849]) HSP 1 Score: 339.732 bits (870), Expect = 1.153e-105 Identity = 209/605 (34.55%), Postives = 321/605 (53.06%), Query Frame = 2
Query: 335 PNIHIRAATIDKLVEELLIHIEQSCESLDDISDDNLVFPKIFFLVHNWFSTSESIGRKLYNNADIKHKSDSSFEDDRILRSNRKFKIGGVTLAFCLWIEFYPNDFMGSESCMPILTKFIESLQEMGREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHL-YNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPK-----SSIDSPVANKSILFGDFVSGVKP---PTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKANHNA-LKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECRSRGHLYQHNRSSSQSTETNVSFQSLGSPP 2119
P ++A++D+LVE + Q+ + + DD+LV ++F ++H W+ S + +KL + + S R+ KI + WI +P +F + + + + L G E ++ SY R ++ R+ + S SL+F+ + +LAE LT +E+K+F +I QD + + + P LER + +FN +SQW+Q M+L+K +RA V+ F+ +A+ LL LQNFN+ AV+GG+++S+ISR+ T +S K+ T++++S NYS+YR+ E GF P++ VHLKDLI H ALPD ++ +N K Q LQ + Q T I+ N DL N L +SLD +TEE+IY++SL REP+ SS + ++ VKP PT ++K H+ MVE+VFK +D D DG IS +EFE + NFP++ F LD ++DG IS+ EM YF+KA+ K F H F E TY KPTFC HC G +WG KQG++C+ CG+N HK C+ ++ +ECR R +S S T + +S PP
Sbjct: 3 PTTSEQSASVDELVEGCI----QAFDDKGTLKDDSLV--RMFLMMHPWYIPSTEMAKKLVLKSQ-----------EETCSSERRTKICHLIK---YWISEFPAEFNLNPELADQIKDYKDLLTTKGNESQSQLIDLDSVPSYKWKRQVTQRVP-----------SVSKKRKMSLLFDHLDSCELAEHLTYLEYKSFCKILFQDYHSFVMHGCTVDNPILERFITLFNSVSQWIQLMVLSKPTAPQRAAVISHFIRVAQKLLQLQNFNTLMAVVGGLSNSSISRLKETQAHISAETNKVFNSLTELVTSCGNYSHYRKRFSECSGFRFPILGVHLKDLIAVHVALPDWADKDKTRVNLTKAQQLYTILQELALIQNTPPNIDANTDLLNLLTVSLDQYHTEEEIYQMSLLREPRKTAQNSSPAPAPEPTPTVIDEWAVSVKPNADPT--IIKIHIEKMVESVFKNFDTDGDGHISRDEFEAIRNNFPYLSKFGELDKNQDGKISREEMIDYFMKASSLLNCKMGFIHTFTEATYVKPTFCEHCAGFIWGFYKQGYKCKACGVNCHKACRSRLAVECRKR------TKSISHETPPALQARSYSFPP 568
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Medaka
Match: RASGRP2 (RAS guanyl releasing protein 2 [Source:NCBI gene;Acc:101160849]) HSP 1 Score: 339.347 bits (869), Expect = 7.747e-105 Identity = 209/605 (34.55%), Postives = 321/605 (53.06%), Query Frame = 2
Query: 335 PNIHIRAATIDKLVEELLIHIEQSCESLDDISDDNLVFPKIFFLVHNWFSTSESIGRKLYNNADIKHKSDSSFEDDRILRSNRKFKIGGVTLAFCLWIEFYPNDFMGSESCMPILTKFIESLQEMGREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHL-YNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPK-----SSIDSPVANKSILFGDFVSGVKP---PTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKANHNA-LKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECRSRGHLYQHNRSSSQSTETNVSFQSLGSPP 2119
P ++A++D+LVE + Q+ + + DD+LV ++F ++H W+ S + +KL + + S R+ KI + WI +P +F + + + + L G E ++ SY R ++ R+ + S SL+F+ + +LAE LT +E+K+F +I QD + + + P LER + +FN +SQW+Q M+L+K +RA V+ F+ +A+ LL LQNFN+ AV+GG+++S+ISR+ T +S K+ T++++S NYS+YR+ E GF P++ VHLKDLI H ALPD ++ +N K Q LQ + Q T I+ N DL N L +SLD +TEE+IY++SL REP+ SS + ++ VKP PT ++K H+ MVE+VFK +D D DG IS +EFE + NFP++ F LD ++DG IS+ EM YF+KA+ K F H F E TY KPTFC HC G +WG KQG++C+ CG+N HK C+ ++ +ECR R +S S T + +S PP
Sbjct: 52 PTTSEQSASVDELVEGCI----QAFDDKGTLKDDSLV--RMFLMMHPWYIPSTEMAKKLVLKSQ-----------EETCSSERRTKICHLIK---YWISEFPAEFNLNPELADQIKDYKDLLTTKGNESQSQLIDLDSVPSYKWKRQVTQRVP-----------SVSKKRKMSLLFDHLDSCELAEHLTYLEYKSFCKILFQDYHSFVMHGCTVDNPILERFITLFNSVSQWIQLMVLSKPTAPQRAAVISHFIRVAQKLLQLQNFNTLMAVVGGLSNSSISRLKETQAHISAETNKVFNSLTELVTSCGNYSHYRKRFSECSGFRFPILGVHLKDLIAVHVALPDWADKDKTRVNLTKAQQLYTILQELALIQNTPPNIDANTDLLNLLTVSLDQYHTEEEIYQMSLLREPRKTAQNSSPAPAPEPTPTVIDEWAVSVKPNADPT--IIKIHIEKMVESVFKNFDTDGDGHISRDEFEAIRNNFPYLSKFGELDKNQDGKISREEMIDYFMKASSLLNCKMGFIHTFTEATYVKPTFCEHCAGFIWGFYKQGYKCKACGVNCHKACRSRLAVECRKR------TKSISHETPPALQARSYSFPP 617
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Medaka
Match: RASGRP1 (RAS guanyl releasing protein 1 [Source:NCBI gene;Acc:101169327]) HSP 1 Score: 338.961 bits (868), Expect = 2.190e-103 Identity = 190/474 (40.08%), Postives = 287/474 (60.55%), Query Frame = 2
Query: 623 WIEFYPNDFMGSESCMPILTKFIESLQEMGREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSP-VANKSILFGDFVSGVKP-PTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKAN--HNALKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECR 2032
WI+ + F S L +F + ++E G+E L + LE + + R S + S +K S SL+F+ + P +LA+ LT +EFK+F RI+ D + Y + +++IP LERS+ + NG+SQWVQ M+L++ RA+V KFL +A++L + N+N+ AV+GG+ HS+ISR+ T + K+L E T ++SS NY NYR GF IP++ VHLKDLI + A+ D++ + N +N K + ++ Q ++ N DL + L LSLDL Y+E++IYELS AREPK+ P +K + D+ SGV P P + +HV MV++VFK YD+D++G IS ++FE +A +FPF SF V+D +K+G++S+ E+ YF++A+ + L F H F E TY KPTFC +C+G LWG+IKQG+RC+DCG+N HK CK+QV EC+
Sbjct: 119 WIQEFWGMFRLHHSLSDKLDEFRDLIREQGQEHLCSLLE----TKWINERDWSWK------ASQKIKANYSKKRKVSLLFDHLEPSELADHLTYLEFKSFCRISFLDFQNYMQSCCMKDIPVLERSIALCNGMSQWVQLMVLSRPTAQLRAEVFTKFLHVAQSLHQMHNYNTLMAVVGGLCHSSISRLKDTTSHVPSEVTKVLNEMTDLLSSCRNYDNYRHAYSRCSGFKIPILGVHLKDLITVNEAMSDYVED-NKVNIHKLQVLYNHINELIQLQQIPPRLDANKDLVHLLTLSLDLYYSEDEIYELSYAREPKNCKAPPSTPSKPPVCVDWASGVAPKPDPRTISKHVQRMVDSVFKNYDHDENGFISHDDFEKIAASFPF--SFCVMDKEKEGMVSREEITAYFMRASVICSKLGLGFVHNFQEATYMKPTFCDNCSGFLWGVIKQGYRCKDCGMNCHKLCKDQVAFECK 579
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Medaka
Match: rasgrp4 (RAS guanyl-releasing protein 1 [Source:NCBI gene;Acc:101159840]) HSP 1 Score: 311.612 bits (797), Expect = 4.092e-94 Identity = 207/568 (36.44%), Postives = 316/568 (55.63%), Query Frame = 2
Query: 353 AATIDKLVEELLIHIEQSCESLDDISDDNLVFPKIFFLVHNWFSTSESIGRKL---YNNADIKHKSDSSFEDDRILRSNRKFKIGGVTLAFCLWIEFYPNDFMGSESCMPILTKFIESLQEMGREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSPVAN-KSILFGDFVSGVKPP-TVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKANHNALKNSFK----HEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMEC 2029
AA++D+L++ L H S + LV + ++H+W S+ +KL Y + SD R +R+ +I + WI +P F P+L + + L + + D + ++S + + + R+++ Q S +K SL+F+ + P ++AE L+ +EFK F ++ D + Y + +VR+ P LERSV + NG+SQWVQ MIL++ +RA+V KF+ +A+ L LQNFN+ AV GG+ HS+ISR+ T L K L E T+++SS +NYSNYR++ + KGF +P++ VHLKDLI + A+PD++ IN K + + +L + E N DL + L LSLDL YTE++IYELS +EPK+ P A K+ + ++ SGV P D + +HV MV+++ K YD ++G IS EEFE +A NFPF SF + D++G IS+ E+ YF++ K + H F+E TY +PTFC C G LWG+IKQG+ C+DCGIN HKHC++ V MEC
Sbjct: 50 AASLDELIQRCL-HCIDSEGKISSPRGSQLVH--MTLMMHSWVVPSQMFAQKLLALYKDC----PSDK--------RGSRRAQICHLVRQ---WISQFPAVF----EVDPLLEQTMGDLWALVQLD-----REKIHSHFIDTSCSNPRVNISQAPSPCVK-----KRKVSLIFDHMEPDEMAEHLSYLEFKNFCNVSFMDYRSYVVRGSVRDNPALERSVMMCNGVSQWVQLMILSRHTAQQRAQVFTKFIHVAQKLRSLQNFNTLMAVTGGLCHSSISRLKDTSNLLPPDVTKALSEMTELLSSRSNYSNYRRVYNDCKGFKVPILGVHLKDLISLNEAMPDYIEEEK-INLSKLQHLYSNINDLLAIHSCKPPFEANKDLLHLLTLSLDLYYTEDEIYELSYTKEPKNPKIQPAAPVKAPVVAEWGSGVTPRLDPDTISKHVKQMVDSIMKNYDPHQEGYISLEEFEKIASNFPF--SFCTQETDREGQISREEITSYFMRGMSVCAKLGYNFNDAHNFHEITYKRPTFCDTCGGFLWGVIKQGYHCKDCGINCHKHCRDLVRMEC 582
BLAST of Ras guanyl-releasing protein 3 vs. Planmine SMEST
Match: SMESG000035948.1 (SMESG000035948.1) HSP 1 Score: 1657.88 bits (4292), Expect = 0.000e+0 Identity = 821/822 (99.88%), Postives = 821/822 (99.88%), Query Frame = 2
Query: 50 MSSYQCTDGLVSHNACATGSTGNIKRTTGKLHERLWPNIKLQKWGKNRRIQSVHSEEPTCSLQKCYSADDNMLGTHMSLSNSVDEEIIYEDHCIVPNIHIRAATIDKLVEELLIHIEQSCESLDDISDDNLVFPKIFFLVHNWFSTSESIGRKLYNNADIKHKSDSSFEDDRILRSNRKFKIGGVTLAFCLWIEFYPNDFMGSESCMPILTKFIESLQEMGREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSPVANKSILFGDFVSGVKPPTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKANHNALKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECRSRGHLYQHNRSSSQSTETNVSFQSLGSPPCSSRQITIDXXXXXXXXXXXXTIVNVETQTSGILSESDMSTLESTSSFEKESNHVCIYSEDDPFDDCDKSHLIETLLRYQKEKNELEIEIKMMQEKFKIQANNIEILQDTVTQLRQKIVKFVLDIMDIFNNH 2515
MSSYQCTDGLVSHNACATGSTGNIKRTTGKLHERLWPNIKLQKWGKNRRIQSVHSEEPTCSLQKCYSADDNMLGTHMSLSNSVDEEIIYEDHCIVPNIHIRAATIDKLVEELLIHIEQSCESLDDISDDNLVFPKIFFLVHNWFSTSESIGRKLYNNADIKHKSDSSFEDDRILRSNRKFKIGGVTLAFCLWIEFYPNDFMGSESCMPILTKFIESLQEMGREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIISSSNNYSNYRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSPVANKSILFGDFVSGVKPPTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKANHNALKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECRSRGHLYQHNRSSSQSTETNVSFQSLGSPPCSSRQITIDRKRKMSQQRKKRTIVNVETQTSGILSESDMSTLESTSSFEKESNHV IYSEDDPFDDCDKSHLIETLLRYQKEKNELEIEIKMMQEKFKIQANNIEILQDTVTQLRQKIVKFVLDIMDIFNNH
Sbjct: 1 MSSYQCTDGLVSHNACATGSTGNIKRTTGKLHERLWPNIKLQKWGKNRRIQSVHSEEPTCSLQKCYSADDNMLGTHMSLSNSVDEEIIYEDHCIVPNIHIRAATIDKLVEELLIHIEQSCESLDDISDDNLVFPKIFFLVHNWFSTSESIGRKLYNNADIKHKSDSSFEDDRILRSNRKFKIGGVTLAFCLWIEFYPNDFMGSESCMPILTKFIESLQEMGREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIISSSNNYSNYRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSPVANKSILFGDFVSGVKPPTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKANHNALKNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECRSRGHLYQHNRSSSQSTETNVSFQSLGSPPCSSRQITIDRKRKMSQQRKKRTIVNVETQTSGILSESDMSTLESTSSFEKESNHVYIYSEDDPFDDCDKSHLIETLLRYQKEKNELEIEIKMMQEKFKIQANNIEILQDTVTQLRQKIVKFVLDIMDIFNNH 822
BLAST of Ras guanyl-releasing protein 3 vs. Planmine SMEST
Match: SMESG000035948.1 (SMESG000035948.1) HSP 1 Score: 1651.72 bits (4276), Expect = 0.000e+0 Identity = 821/826 (99.39%), Postives = 821/826 (99.39%), Query Frame = 2
Query: 50 MSSYQCTDGLVSHNACATGSTGNIKRTTGKLHERLWPNIKLQKWGKNRRIQSVHSEEPTCSLQKCYSADDNMLGTHMSLSNSVDEEIIYEDHCIVPNIHIRAATIDKLVEELLIHIEQSCESLDDISDDNLVFPKIFFLVHNWFSTSESIGRKLYNNADIKHKSDSSFEDDRILRSNRKFKIGGVTLAFCLWIEFYPNDFMGSESCMPILTKFIESLQEMGREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSPVANKSILFGDFVSGVKPPTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKANHNALKNSFKHEFYENTYFKPTFCTHCTGL----LWGLIKQGWRCRDCGINAHKHCKEQVVMECRSRGHLYQHNRSSSQSTETNVSFQSLGSPPCSSRQITIDXXXXXXXXXXXXTIVNVETQTSGILSESDMSTLESTSSFEKESNHVCIYSEDDPFDDCDKSHLIETLLRYQKEKNELEIEIKMMQEKFKIQANNIEILQDTVTQLRQKIVKFVLDIMDIFNNH 2515
MSSYQCTDGLVSHNACATGSTGNIKRTTGKLHERLWPNIKLQKWGKNRRIQSVHSEEPTCSLQKCYSADDNMLGTHMSLSNSVDEEIIYEDHCIVPNIHIRAATIDKLVEELLIHIEQSCESLDDISDDNLVFPKIFFLVHNWFSTSESIGRKLYNNADIKHKSDSSFEDDRILRSNRKFKIGGVTLAFCLWIEFYPNDFMGSESCMPILTKFIESLQEMGREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIISSSNNYSNYRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSPVANKSILFGDFVSGVKPPTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKANHNALKNSFKHEFYENTYFKPTFCTHCTGL LWGLIKQGWRCRDCGINAHKHCKEQVVMECRSRGHLYQHNRSSSQSTETNVSFQSLGSPPCSSRQITIDRKRKMSQQRKKRTIVNVETQTSGILSESDMSTLESTSSFEKESNHV IYSEDDPFDDCDKSHLIETLLRYQKEKNELEIEIKMMQEKFKIQANNIEILQDTVTQLRQKIVKFVLDIMDIFNNH
Sbjct: 1 MSSYQCTDGLVSHNACATGSTGNIKRTTGKLHERLWPNIKLQKWGKNRRIQSVHSEEPTCSLQKCYSADDNMLGTHMSLSNSVDEEIIYEDHCIVPNIHIRAATIDKLVEELLIHIEQSCESLDDISDDNLVFPKIFFLVHNWFSTSESIGRKLYNNADIKHKSDSSFEDDRILRSNRKFKIGGVTLAFCLWIEFYPNDFMGSESCMPILTKFIESLQEMGREDLITTLEKSLNSSYDRSRGLSLRMSVRQPVSNSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDLKLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIISSSNNYSNYRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDLCNTLRLSLDLQYTEEDIYELSLAREPKSSIDSPVANKSILFGDFVSGVKPPTVDVLKQHVNGMVEAVFKVYDNDKDGLISSEEFELVAENFPFIDSFAVLDADKDGVISKYEMKMYFLKANHNALKNSFKHEFYENTYFKPTFCTHCTGLVSEQLWGLIKQGWRCRDCGINAHKHCKEQVVMECRSRGHLYQHNRSSSQSTETNVSFQSLGSPPCSSRQITIDRKRKMSQQRKKRTIVNVETQTSGILSESDMSTLESTSSFEKESNHVYIYSEDDPFDDCDKSHLIETLLRYQKEKNELEIEIKMMQEKFKIQANNIEILQDTVTQLRQKIVKFVLDIMDIFNNH 826
BLAST of Ras guanyl-releasing protein 3 vs. Planmine SMEST
Match: SMESG000014113.1 (SMESG000014113.1) HSP 1 Score: 77.7962 bits (190), Expect = 2.457e-14 Identity = 72/274 (26.28%), Postives = 134/274 (48.91%), Query Frame = 2
Query: 812 NSLKLASSNSETCSLVFNQIHPLKLAEQLTVIEFKAFRRITIQDL--KLYSLTATVRNIPTLERSVYIFNGLSQWVQCMILNKTAPSERAKVVEKFLLIAENLLVLQNFNSFYAVIGGITHSAISRMNATMMSLSISAQKMLEEYTKIIXXXXXXXXXRQLQKEAKGFHIPVVAVHLKDLIFYHTALPDHLYNRNLINFRKFAQSAATLQSILDQQLTQMCIEQNIDL-CNTLRLSLDLQY---------TEEDIYELSLAREPK--SSIDSPV 1591
N + L++ +E+ S +F+ +LA LT +++ F+ I + +L K+ + R L+ + F + WV + R +V+K + +A L L+N +S +AV+ G+ +SA++R+ T LS +K+ ++ ++ + N+ +RQ K+ IP A+ LKDL F + A + ++ N+INF K AA++ +L + M E + + + L ++DLQ ++ + +LSL E K SS PV
Sbjct: 817 NHVGLSNIKTESSS-IFDSTSIDELAFHLTYFDWQLFKNIHVYELLFKVLGRSKFGRITSNLDAFIRQFTNIQYWVVTEVCQCQNLQRRVNIVKKMIKLASRLSELKNISSGFAVLMGLNNSAVARLQMTWERLSSKHRKLFQDLCSLLDPTRNHCAFRQYLKKTPPPIIPFFAIMLKDLTFINDANKTY-FDDNMINFEKMQMYAASMHQVLHCRARPMIFENSTSMKKDKLSNTIDLQNYVRNFKCLDNQKQLTQLSLGLEAKQLSSNSLPV 1088
BLAST of Ras guanyl-releasing protein 3 vs. Planmine SMEST
Match: SMESG000061526.1 (SMESG000061526.1) HSP 1 Score: 67.3958 bits (163), Expect = 4.656e-11 Identity = 30/77 (38.96%), Postives = 42/77 (54.55%), Query Frame = 2
Query: 1823 EMKMYFLKANHNAL----KNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECRSRG 2041
E+KM+ K A+ ++ H F KPTFC C GLLWG+ +QG RC +CG+ H+ CKE + +C R
Sbjct: 920 ELKMHVYKKTLQAMIYPISSNTPHSFQVLNATKPTFCYECEGLLWGVARQGLRCIECGVKCHEKCKELLNADCLQRA 996
BLAST of Ras guanyl-releasing protein 3 vs. Planmine SMEST
Match: SMESG000061526.1 (SMESG000061526.1) HSP 1 Score: 67.3958 bits (163), Expect = 4.741e-11 Identity = 30/77 (38.96%), Postives = 42/77 (54.55%), Query Frame = 2
Query: 1823 EMKMYFLKANHNAL----KNSFKHEFYENTYFKPTFCTHCTGLLWGLIKQGWRCRDCGINAHKHCKEQVVMECRSRG 2041
E+KM+ K A+ ++ H F KPTFC C GLLWG+ +QG RC +CG+ H+ CKE + +C R
Sbjct: 920 ELKMHVYKKTLQAMIYPISSNTPHSFQVLNATKPTFCYECEGLLWGVARQGLRCIECGVKCHEKCKELLNADCLQRA 996 The following BLAST results are available for this feature:
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Ras guanyl-releasing protein 3 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Ras guanyl-releasing protein 3 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 1
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Ras guanyl-releasing protein 3 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Ras guanyl-releasing protein 3 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30031682 ID=SMED30031682|Name=Ras guanyl-releasing protein 3|organism=Schmidtea mediterranea sexual|type=transcript|length=2654bpback to top protein sequence of SMED30031682-orf-1 >SMED30031682-orf-1 ID=SMED30031682-orf-1|Name=SMED30031682-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=823bp MSSYQCTDGLVSHNACATGSTGNIKRTTGKLHERLWPNIKLQKWGKNRRIback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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