Metalloendopeptidase

Overview


Name	Metalloendopeptidase
Smed ID	SMED30031572
Length (bp)	868

Neoblast Clusters

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Metalloendopeptidase (SMED30031572) t-SNE clustered cells

Violin plots show distribution of expression levels for Metalloendopeptidase (SMED30031572) in cells (dots) of each of the 12 neoblast clusters.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30031572

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 20

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
prepharyngeal region	SMED30031572	h1SMcG0009025	SmedASXL_009673	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
parapharyngeal region	SMED30031572	h1SMcG0009025	SmedASXL_009673	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
prepharyngeal region	SMED30031572	h1SMcG0009025	SmedASXL_009674	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
parapharyngeal region	SMED30031572	h1SMcG0009025	SmedASXL_009674	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
prepharyngeal region	SMED30031572	h1SMcG0009025	SmedASXL_009673	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
parapharyngeal region	SMED30031572	h1SMcG0009025	SmedASXL_009673	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
prepharyngeal region	SMED30031572	h1SMcG0009025	SmedASXL_009674	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
parapharyngeal region	SMED30031572	h1SMcG0009025	SmedASXL_009674	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
Smed sexual biotype	SMED30031572	h1SMcG0009037	Contig4486	GPL15192	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30031572	h1SMcG0009027	Contig4486	GPL15192	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30031572	h1SMcG0009025	Contig4486	GPL15192	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30031572	h1SMcG0009037	Contig4486	GPL15192	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30031572	h1SMcG0009027	Contig4486	GPL15192	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30031572	h1SMcG0009025	Contig4486	GPL15192	PMID:29674431 Fincher et al., 2018
head region	SMED30031572	h1SMcG0009025	OX_Smed_1.0.21359	ox_Smed_v2	PMID:24238224 Kao et al., 2013
head region	SMED30031572	h1SMcG0009025	OX_Smed_1.0.21359	ox_Smed_v2	PMID:24238224 Kao et al., 2013
neoblast	SMED30031572	h1SMcG0009025	SMED_01010_V2_1r	GPL14150	PMID:22385657 Wagner et al., 2012
neoblast	SMED30031572	h1SMcG0009027	SMED_01010_V2_1r	GPL14150	PMID:22385657 Wagner et al., 2012
neoblast	SMED30031572	h1SMcG0009025	SMED_01010_V2_1r	GPL14150	PMID:22385657 Wagner et al., 2012
neoblast	SMED30031572	h1SMcG0009027	SMED_01010_V2_1r	GPL14150	PMID:22385657 Wagner et al., 2012

Note: Hover over icons to view figure legend

Homology

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BLAST of Metalloendopeptidase vs. Ensembl Human
Match: ASTL (astacin like metalloendopeptidase [Source:HGNC Symbol;Acc:HGNC:31704])

HSP 1 Score: 87.0409 bits (214), Expect = 1.058e-18
Identity = 64/227 (28.19%), Postives = 108/227 (47.58%), Query Frame = 1

Query:  178 LDNVKMGDMLLDSTDIQIINGFKNHYANSKKWPNN-----IVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKF---QEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMY-SKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFA--CVPGENVVFKRDGGLIDYNHVTSRNDLDMVRKFYAC 825
            L+       L++  DI   + F+   A S KWP        V +  +  + +   Q + ++L E ++    C++F   Q+ R+  +I +     GC+S +G +GG  Q ++L  P C+   +G + HE +H LGF H H R DRD +I + W+ IL      F+K +  ++  PY+ +SVMHY    F+   +P    ++      I      S +D+  V K Y C
Sbjct:   64 LEETPESSFLIEG-DIIRPSPFRLLSATSNKWPMGGSGVVEVPFLLSSKYDEPSRQVILEALAEFERS--TCIRFVTYQDQRD--FISII-PMYGCFSSVGRSGG-MQVVSLA-PTCLQKGRGIVLHELMHVLGFWHEHTRADRDRYIRVNWNEILPGFEINFIKSQSSNMLTPYDYSSVMHYGRLAFSRRGLPTITPLWA-PSVHIGQRWNLSASDITRVLKLYGC 281

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BLAST of Metalloendopeptidase vs. Ensembl Human
Match: TLL2 (tolloid like 2 [Source:HGNC Symbol;Acc:HGNC:11844])

HSP 1 Score: 77.7962 bits (190), Expect = 2.458e-15
Identity = 58/194 (29.90%), Postives = 86/194 (44.33%), Query Frame = 1

Query:  271 WPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGHYIEVNSKRE-GCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCD---LDGPYETNSVMHYPSYGFACVPGENVVFKR--DGGL---IDYNHVTSRNDLDMVRKFYAC 825
            WP  ++ Y   GNF   +    +Q++   +K    CV F E  +     V S R  GC S +G  GG  Q +++      +  G + HE  H +GF H H R DRD H+TI  + I       F+K E  +   L   Y+ +S+MHY    F+     + +  R  D G+   I      S+ D+   RK Y C
Sbjct:  159 WPGGVIPYVIGGNFTGSQRAIFKQAMRHWEK--HTCVTFIERTDEESFIVFSYRTCGCCSYVGRRGGGPQAISIGKNCDKF--GIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRQDDNGVRPTIGQRVRLSQGDIAQARKLYKC 348

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BLAST of Metalloendopeptidase vs. Ensembl Human
Match: MEP1A (meprin A subunit alpha [Source:HGNC Symbol;Acc:HGNC:7015])

HSP 1 Score: 76.6406 bits (187), Expect = 5.395e-15
Identity = 54/163 (33.13%), Postives = 83/163 (50.92%), Query Frame = 1

Query:  367 LQNCVKFQ--EGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEG---CDLDGPYETNSVMHYPSYGF---ACVPGENVVFKRDGGLIDYNHVTSRNDLDMVRKFYAC*T 831
            L++CV F+  EG + + I    + +GC+S +G      Q +++   GC Y K  I+HE +HALGF H   R DRD+++ I WD+IL+ +   F   +     DL+ PY+  S+MHY  + F   A VP           +I      S  DL+ + + Y C T
Sbjct:  132 LKSCVDFKPYEGESSYII--FQQFDGCWSEVG-DQHVGQNISI-GQGCAY-KAIIEHEILHALGFYHEQSRTDRDDYVNIWWDQILSGYQHNFDTYDDSLITDLNTPYDYESLMHYQPFSFNKNASVPTITAKIPEFNSIIGQRLDFSAIDLERLNRMYNCTT 289

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BLAST of Metalloendopeptidase vs. Ensembl Human
Match: MEP1A (meprin A subunit alpha [Source:HGNC Symbol;Acc:HGNC:7015])

HSP 1 Score: 76.6406 bits (187), Expect = 5.426e-15
Identity = 54/163 (33.13%), Postives = 83/163 (50.92%), Query Frame = 1

Query:  367 LQNCVKFQ--EGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEG---CDLDGPYETNSVMHYPSYGF---ACVPGENVVFKRDGGLIDYNHVTSRNDLDMVRKFYAC*T 831
            L++CV F+  EG + + I    + +GC+S +G      Q +++   GC Y K  I+HE +HALGF H   R DRD+++ I WD+IL+ +   F   +     DL+ PY+  S+MHY  + F   A VP           +I      S  DL+ + + Y C T
Sbjct:  104 LKSCVDFKPYEGESSYII--FQQFDGCWSEVG-DQHVGQNISI-GQGCAY-KAIIEHEILHALGFYHEQSRTDRDDYVNIWWDQILSGYQHNFDTYDDSLITDLNTPYDYESLMHYQPFSFNKNASVPTITAKIPEFNSIIGQRLDFSAIDLERLNRMYNCTT 261

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BLAST of Metalloendopeptidase vs. Ensembl Human
Match: TLL1 (tolloid like 1 [Source:HGNC Symbol;Acc:HGNC:11843])

HSP 1 Score: 75.485 bits (184), Expect = 7.652e-15
Identity = 55/198 (27.78%), Postives = 88/198 (44.44%), Query Frame = 1

Query:  259 NSKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGH-YIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDG---PYETNSVMHYPSYGFACVPGENVVF--KRDGGL---IDYNHVTSRNDLDMVRKFYAC 825
              + WP  ++ Y   GNF   +    +Q++   +K    CV F E  +   YI    +  GC S +G  G   Q +++      +  G + HE  H +GF H H R DRDNH+TI  + I       F+K E  +++     Y+ +S+MHY    F+     + +   + D G+   I      S+ D+   RK Y C
Sbjct:  153 TERIWPGGVIPYVIGGNFTGSQRAMFKQAMRHWEK--HTCVTFIERSDEESYIVFTYRPCGCCSYVGRRGNGPQAISIGKNCDKF--GIVVHELGHVIGFWHEHTRPDRDNHVTIIRENIQPGQEYNFLKMEPGEVNSLGERYDFDSIMHYARNTFSRGMFLDTILPSRDDNGIRPAIGQRTRLSKGDIAQARKLYRC 346

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BLAST of Metalloendopeptidase vs. Ensembl Celegans
Match: nas-4 (Zinc metalloproteinase nas-4 [Source:UniProtKB/Swiss-Prot;Acc:P55112])

HSP 1 Score: 102.064 bits (253), Expect = 5.827e-25
Identity = 73/230 (31.74%), Postives = 114/230 (49.57%), Query Frame = 1

Query:  178 LDNVKMGDMLLDSTDIQII-------NGFKNHYANSKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKF---QEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEG---CDLDGPYETNSVMHYPSYGFACVPGENVVFKRDGGLIDYNHVT-SRNDLDMVRKFYAC 825
            + N   GD+LL+S    +        N  K  Y   ++WPNN + YT +  +       +  ++ E     + CVKF      ++  Y+ ++   EGCYS++G TGG  QP++L++ GC+   GTI HE +HA+GF H   R+DRD++I + W  ++     QF K        LD PY+  S+MHY  Y F+    + +V K+ G       V  S  D+  + K Y C
Sbjct:   69 IGNYSEGDILLESPKKFVEENNKLGRNAIKQIY---RRWPNNEIPYTLSSQYGSYARSVIANAMNEYHT--KTCVKFVARDPSKHHDYLWIHPD-EGCYSLVGKTGG-KQPVSLDS-GCI-QVGTIVHELMHAVGFFHEQSRQDRDSYIDVVWQNVMNGADDQFEKYNLNVISHLDEPYDYASIMHYGPYAFSGSGKKTLVPKKSGSERMGQRVKFSDIDVRKINKLYNC 289

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BLAST of Metalloendopeptidase vs. Ensembl Celegans
Match: nas-4 (Zinc metalloproteinase nas-4 [Source:UniProtKB/Swiss-Prot;Acc:P55112])

HSP 1 Score: 101.679 bits (252), Expect = 1.350e-24
Identity = 73/230 (31.74%), Postives = 114/230 (49.57%), Query Frame = 1

Query:  178 LDNVKMGDMLLDSTDIQI-------INGFKNHYANSKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKF---QEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEG---CDLDGPYETNSVMHYPSYGFACVPGENVVFKRDGGLIDYNHVT-SRNDLDMVRKFYAC 825
            + N   GD+LL+S    +        N  K  Y   ++WPNN + YT +  +       +  ++ E     + CVKF      ++  Y+ ++   EGCYS++G TGG  QP++L++ GC+   GTI HE +HA+GF H   R+DRD++I + W  ++     QF K        LD PY+  S+MHY  Y F+    + +V K+ G       V  S  D+  + K Y C
Sbjct:   69 IGNYSEGDILLESPKKFVEENNKLGRNAIKQIY---RRWPNNEIPYTLSSQYGSYARSVIANAMNEYHT--KTCVKFVARDPSKHHDYLWIHPD-EGCYSLVGKTGG-KQPVSLDS-GCI-QVGTIVHELMHAVGFFHEQSRQDRDSYIDVVWQNVMNGADDQFEKYNLNVISHLDEPYDYASIMHYGPYAFSGSGKKTLVPKKSGSERMGQRVKFSDIDVRKINKLYNC 289

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BLAST of Metalloendopeptidase vs. Ensembl Celegans
Match: nas-4 (Zinc metalloproteinase nas-4 [Source:UniProtKB/Swiss-Prot;Acc:P55112])

HSP 1 Score: 101.679 bits (252), Expect = 1.384e-24
Identity = 73/230 (31.74%), Postives = 114/230 (49.57%), Query Frame = 1

Query:  178 LDNVKMGDMLLDSTDIQI-------INGFKNHYANSKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKF---QEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEG---CDLDGPYETNSVMHYPSYGFACVPGENVVFKRDGGLIDYNHVT-SRNDLDMVRKFYAC 825
            + N   GD+LL+S    +        N  K  Y   ++WPNN + YT +  +       +  ++ E     + CVKF      ++  Y+ ++   EGCYS++G TGG  QP++L++ GC+   GTI HE +HA+GF H   R+DRD++I + W  ++     QF K        LD PY+  S+MHY  Y F+    + +V K+ G       V  S  D+  + K Y C
Sbjct:   69 IGNYSEGDILLESPKKFVEENNKLGRNAIKQIY---RRWPNNEIPYTLSSQYGSYARSVIANAMNEYHT--KTCVKFVARDPSKHHDYLWIHPD-EGCYSLVGKTGG-KQPVSLDS-GCI-QVGTIVHELMHAVGFFHEQSRQDRDSYIDVVWQNVMNGADDQFEKYNLNVISHLDEPYDYASIMHYGPYAFSGSGKKTLVPKKSGSERMGQRVKFSDIDVRKINKLYNC 289

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BLAST of Metalloendopeptidase vs. Ensembl Celegans
Match: nas-6 (Zinc metalloproteinase nas-6 [Source:UniProtKB/Swiss-Prot;Acc:Q9U3S9])

HSP 1 Score: 89.7373 bits (221), Expect = 2.354e-20
Identity = 68/206 (33.01%), Postives = 100/206 (48.54%), Query Frame = 1

Query:  229 IINGFKNHYANSKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGHYIEVN-SKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGC--DLDGP-YETNSVMHYPSYGFACVPGENVVFKRDGGLIDY-NHVTSRNDLDMVR--KFYAC 825
            + N  KN       W   ++ Y     F  ++I+ + ++    ++    C++F E R G    +N  K  GCYS +G TGG  Q ++L   GC + +  I HE +H++GF H H R DRD+HI I WD IL    SQF K      DL G  Y+  S+MHY S  F+   G N +   + G           + LD+V+  K Y+C
Sbjct:   70 LFNALKN---KQLTWEGGVIPYEMDTAFSPNEIKILEKAFDSYRR--TTCIRF-EKREGQTDYLNIVKGYGCYSQVGRTGG-KQEISLGR-GCFFHE-IIVHELMHSVGFWHEHSRADRDDHIKINWDNILPGMKSQFDKISAVLQDLQGENYDYKSIMHYDSTAFS-RNGRNTIETVENGFTQVIGTAMDLSPLDIVKINKLYSC 265

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BLAST of Metalloendopeptidase vs. Ensembl Celegans
Match: nas-14 (Zinc metalloproteinase nas-14 [Source:UniProtKB/Swiss-Prot;Acc:Q19269])

HSP 1 Score: 86.6557 bits (213), Expect = 6.696e-19
Identity = 61/193 (31.61%), Postives = 86/193 (44.56%), Query Frame = 1

Query:  265 KKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGHYIEVNSKRE---GCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDG---PYETNSVMHYPSYGFACVPGENVVFKRDGGLIDYNHVTSRNDLDMVRKFYAC 825
            K WP   V Y        D+   + Q+  E +   + CV+F    +  +  +  KR    GC S +G  GG +Q ++LE   C +SKG I HE +HALGF H H R DRD+ + I  D I       F K     +D    PY+  SVMHY    F+      ++ K +   +   +  S  D   V K Y C
Sbjct:  123 KLWPEGQVPYMLEEGMTNDQRTAIAQAFDEYK--TKTCVRFVPKTDDDFDYIYVKRNVAFGCSSYVGRAGG-NQTVSLEVDKC-FSKGIIAHELMHALGFFHEHSRTDRDDFVDINEDNIRPGMMRNFEKYPRKIIDSLGMPYDYESVMHYHKLAFSRNGKPTIIPKDNEADVGQRYKLSEMDSKKVNKLYQC 311

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BLAST of Metalloendopeptidase vs. Ensembl Fly
Match: CG6763 (gene:FBgn0039069 transcript:FBtr0084378)

HSP 1 Score: 122.094 bits (305), Expect = 3.979e-32
Identity = 62/176 (35.23%), Postives = 97/176 (55.11%), Query Frame = 1

Query:  196 GDMLLDSTDIQIINGFKNHYANSKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKF-QEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDG-PYETNSVMHYPSYGFA 717
            GDML+  TD+ + NG       S +WPN +V Y   GNF    + T+  ++GE  +  + C++F +      YI +     GC+S +G  GG  Q +NL++PGC+   GT  HE +HALGF+H   R +RD ++ I+++ + +S  + F K    +  G PY+  SVMHY    F+
Sbjct:   95 GDMLVPQTDLIMKNGLPTQ---SSRWPNGVVPYEIRGNFNARDMATIENAIGEYHR--RTCIRFVKRSSERDYISIRGDNSGCWSSVGRVGG-KQEVNLQSPGCLSRPGTAMHELMHALGFLHEQNRMERDGYVAIQYNNVQSSAMNNFEKAARTEAFGVPYDYGSVMHYSKNAFS 264

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BLAST of Metalloendopeptidase vs. Ensembl Fly
Match: CG6763 (gene:FBgn0039069 transcript:FBtr0334497)

HSP 1 Score: 122.094 bits (305), Expect = 3.979e-32
Identity = 62/176 (35.23%), Postives = 97/176 (55.11%), Query Frame = 1

Query:  196 GDMLLDSTDIQIINGFKNHYANSKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKF-QEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDG-PYETNSVMHYPSYGFA 717
            GDML+  TD+ + NG       S +WPN +V Y   GNF    + T+  ++GE  +  + C++F +      YI +     GC+S +G  GG  Q +NL++PGC+   GT  HE +HALGF+H   R +RD ++ I+++ + +S  + F K    +  G PY+  SVMHY    F+
Sbjct:   95 GDMLVPQTDLIMKNGLPTQ---SSRWPNGVVPYEIRGNFNARDMATIENAIGEYHR--RTCIRFVKRSSERDYISIRGDNSGCWSSVGRVGG-KQEVNLQSPGCLSRPGTAMHELMHALGFLHEQNRMERDGYVAIQYNNVQSSAMNNFEKAARTEAFGVPYDYGSVMHYSKNAFS 264

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BLAST of Metalloendopeptidase vs. Ensembl Fly
Match: CG15255 (gene:FBgn0028950 transcript:FBtr0080785)

HSP 1 Score: 93.2041 bits (230), Expect = 4.372e-22
Identity = 63/207 (30.43%), Postives = 99/207 (47.83%), Query Frame = 1

Query:  235 NGFKNHYANSKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEG--RNGHYIEVNSKREGCYSMLGVTGGPSQPLNLE----NPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEG---CDLDGPYETNSVMHYPSYGFACVPGENVVFKRDGGLIDYNHV-TSRNDLDMVRKFYAC 825
            NG  N     K+WP N+V Y  + +F     + ++  +  L+  L  C++F+E    +  Y+ V +K  GCY+ +G  G P Q +NLE      GC +  GTI HEF+HALGF H      RD+ I + ++ I+      F K       D +  Y+ +S +HY    F+ + GE+ +   D   +    V  S  D+D +   Y C
Sbjct:   59 NGLIN---TEKRWPGNVVVYRISDDFDTAHKKAIQTGIDTLE--LHTCLRFREATDEDKAYLTVTAKSGGCYTAVGYQGAP-QEMNLEIYPLGEGC-FRPGTILHEFMHALGFYHQQSSSIRDDFINVIYENIVPGKEFNFQKYADTVVTDFEVGYDYDSCLHYRPGAFS-INGEDTIVPLDSSAVIGQRVGLSSKDIDKINIMYKC 257

[Close]

BLAST of Metalloendopeptidase vs. Ensembl Fly
Match: CG15255 (gene:FBgn0028950 transcript:FBtr0343719)

HSP 1 Score: 93.2041 bits (230), Expect = 4.372e-22
Identity = 63/207 (30.43%), Postives = 99/207 (47.83%), Query Frame = 1

Query:  235 NGFKNHYANSKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEG--RNGHYIEVNSKREGCYSMLGVTGGPSQPLNLE----NPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEG---CDLDGPYETNSVMHYPSYGFACVPGENVVFKRDGGLIDYNHV-TSRNDLDMVRKFYAC 825
            NG  N     K+WP N+V Y  + +F     + ++  +  L+  L  C++F+E    +  Y+ V +K  GCY+ +G  G P Q +NLE      GC +  GTI HEF+HALGF H      RD+ I + ++ I+      F K       D +  Y+ +S +HY    F+ + GE+ +   D   +    V  S  D+D +   Y C
Sbjct:   59 NGLIN---TEKRWPGNVVVYRISDDFDTAHKKAIQTGIDTLE--LHTCLRFREATDEDKAYLTVTAKSGGCYTAVGYQGAP-QEMNLEIYPLGEGC-FRPGTILHEFMHALGFYHQQSSSIRDDFINVIYENIVPGKEFNFQKYADTVVTDFEVGYDYDSCLHYRPGAFS-INGEDTIVPLDSSAVIGQRVGLSSKDIDKINIMYKC 257

[Close]

BLAST of Metalloendopeptidase vs. Ensembl Fly
Match: CG11865 (gene:FBgn0028947 transcript:FBtr0080753)

HSP 1 Score: 91.6633 bits (226), Expect = 1.302e-21
Identity = 70/254 (27.56%), Postives = 115/254 (45.28%), Query Frame = 1

Query:  100 LGFVVIDYANGQCGCPRQSVKLRTRGLDNVKMGDMLLDSTDIQ---------IINGFKNHYANSKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQ--EGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQF--VKCEGCDLDG-PYETNSVMHYPSYGFACVPGENVVFKRDGGLIDYNHVTSRNDLDMVRKFY 819
            L   VI +  G     R S+KL+          D++L S  +Q         ++  +  +Y     W    + Y++AG F    I ++  ++ E+    + CVKF+  E +    + +  +  GC+S +G  G   Q LNL   GCM S  TI+HE +HALGF HTH    RD ++ I+ D I + H   F  ++  G    G  Y+ +S+MHY  + F+      +V  +    I      S  D+  +++ Y
Sbjct:    4 LALAVI-FGLGSSANGRPSIKLQE--------DDIILISEQLQYFEGNLEGRVVKSWSEYY-----WKGRTLVYSYAGGFSSLDIASIESAMAEISS--KTCVKFRRTEYKREPQVVIQKEGSGCWSYVGYLGRADQTLNL-GSGCM-SNRTIQHELLHALGFFHTHSDPQRDKYVRIQTDNIRSGHEHNFQRLRANGVTNYGFGYDYDSIMHYGPFAFSKNGQSTIVPLKSHAKIGQATQMSPKDVQTLKRMY 239

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BLAST of Metalloendopeptidase vs. Ensembl Zebrafish
Match: hce2l1 (high choriolytic enzyme 2-like 1 [Source:ZFIN;Acc:ZDB-GENE-070912-147])

HSP 1 Score: 102.064 bits (253), Expect = 1.109e-25
Identity = 58/170 (34.12%), Postives = 91/170 (53.53%), Query Frame = 1

Query:  256 ANSKKWPNNIVTYTFAGNFPQ---DKIQTVRQSLGELQKDLQNCVKF-QEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFACVPGENVVFKRD 753
             +S +WP  +  + +         D +  +    G L      CVKF       +++ +   R GC+S LG+TGG SQ ++L++PGCM+S G   HE +HALGF+H   R DRD +++I W+ I+ +    F K E  +L+  Y+ +SVMHY  Y F+   G  ++ K D
Sbjct:   24 GDSCRWPKAVDGFVYVPYIMSTLYDDMDRITIETGMLDISSSTCVKFVPRTHQANFLNIQ-PRYGCWSYLGMTGG-SQTVSLQSPGCMWS-GVASHELMHALGFVHEQSRSDRDRYVSILWENIIENQRHNFRKYETNNLNTAYDYSSVMHYGRYAFSEDGGPTIIPKPD 190

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BLAST of Metalloendopeptidase vs. Ensembl Zebrafish
Match: hce2l1 (high choriolytic enzyme 2-like 1 [Source:ZFIN;Acc:ZDB-GENE-070912-147])

HSP 1 Score: 102.449 bits (254), Expect = 2.970e-25
Identity = 60/172 (34.88%), Postives = 93/172 (54.07%), Query Frame = 1

Query:  256 ANSKKWPNNI-----VTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKF-QEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFACVPGENVVFKRD 753
             +S +WP  +     V Y  +  +  D +  +    G L      CVKF       +++ +   R GC+S LG+TGG SQ ++L++PGCM+S G   HE +HALGF+H   R DRD +++I W+ I+ +    F K E  +L+  Y+ +SVMHY  Y F+   G  ++ K D
Sbjct:   82 GDSCRWPKAVDGFVYVPYIMSTLY--DDMDRITIETGMLDISSSTCVKFVPRTHQANFLNIQ-PRYGCWSYLGMTGG-SQTVSLQSPGCMWS-GVASHELMHALGFVHEQSRSDRDRYVSILWENIIENQRHNFRKYETNNLNTAYDYSSVMHYGRYAFSEDGGPTIIPKPD 248

[Close]

BLAST of Metalloendopeptidase vs. Ensembl Zebrafish
Match: hce2l2 (high choriolytic enzyme 2-like 2 [Source:ZFIN;Acc:ZDB-GENE-070912-146])

HSP 1 Score: 100.908 bits (250), Expect = 1.101e-24
Identity = 61/202 (30.20%), Postives = 104/202 (51.49%), Query Frame = 1

Query:  244 KNHYANSKKWPNNI-----VTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKF-QEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFACVPGENVVFKRDGGLIDYNHVTSRNDLDMVR--KFYAC 825
            KN +A S  W  ++     + Y+ +  +    ++ +++ +  +++D   CV+F        Y+++  K  GC+S LG  GG  Q ++L++P C  S G   HE +HALGF+H   R DRD ++TI W  I       F K +  +LD PY+ +SVMH+  Y F+   GE  +  +    +        +DLD+++  K Y+C
Sbjct:   78 KNCFARSCLWTKSVDGNVYIAYSLSHAYDDADVKNIKEGMELIEQD--TCVRFVPRTHQRDYLDIQPK-TGCWSYLGARGG-RQTISLQSPDCTGS-GVTVHELMHALGFVHEQSRADRDKYVTIMWSNIWKDRLRNFEKFKTNNLDTPYDYSSVMHFGKYAFS-EDGEPTIVPKRNWNVKIGQRLGPSDLDIMKINKLYSC 273

[Close]

BLAST of Metalloendopeptidase vs. Ensembl Zebrafish
Match: hce2l2 (high choriolytic enzyme 2-like 2 [Source:ZFIN;Acc:ZDB-GENE-070912-146])

HSP 1 Score: 97.0561 bits (240), Expect = 7.990e-24
Identity = 60/201 (29.85%), Postives = 103/201 (51.24%), Query Frame = 1

Query:  244 KNHYANSKKWPNNI-----VTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKF-QEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFACVPGENVVFKRDGGLIDYNHVTSRNDLDMVR--KFYA 822
            KN +A S  W  ++     + Y+ +  +    ++ +++ +  +++D   CV+F        Y+++  K  GC+S LG  GG  Q ++L++P C  S G   HE +HALGF+H   R DRD ++TI W  I       F K +  +LD PY+ +SVMH+  Y F+   GE  +  +    +        +DLD+++  K Y+
Sbjct:   19 KNCFARSCLWTKSVDGNVYIAYSLSHAYDDADVKNIKEGMELIEQD--TCVRFVPRTHQRDYLDIQPK-TGCWSYLGARGG-RQTISLQSPDCTGS-GVTVHELMHALGFVHEQSRADRDKYVTIMWSNIWKDRLRNFEKFKTNNLDTPYDYSSVMHFGKYAFS-EDGEPTIVPKRNWNVKIGQRLGPSDLDIMKINKLYS 213

[Close]

BLAST of Metalloendopeptidase vs. Ensembl Zebrafish
Match: he1.2 (hatching enzyme 1, tandem dupliate 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2100])

HSP 1 Score: 96.2857 bits (238), Expect = 5.430e-23
Identity = 66/199 (33.17%), Postives = 95/199 (47.74%), Query Frame = 1

Query:  265 KKWPNNIVT--YTFAGNFPQDKIQTVRQSLGELQKDLQNCVKF-QEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFACVPG---------ENVVFKRDGGLIDYNHVTSRNDLDMVRKFYAC 825
            KK  NNIV   Y  +G F  +    +  ++       Q C++F        Y+ + +K +GCYS +G TGG  Q ++L   GC+YS G  +HE  HALGF H   R DRD ++ I W+ I       F+K +  + + PY+  S+MHY    FA  PG         ENV   +  GL       S+ D+  + K Y C
Sbjct:   77 KKNANNIVEVPYVVSGEFSINDKSVIANAISIFHA--QTCIRFVPRSIQADYLSIENK-DGCYSAIGRTGG-KQVVSLNRKGCVYS-GIAQHELNHALGFYHEQSRSDRDQYVRINWNNISPGMAYNFLKQKTNNQNTPYDYGSLMHYGKTAFAIQPGLETITPIPDENVQIGQRQGL-------SKIDILRINKLYGC 263

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BLAST of Metalloendopeptidase vs. Ensembl Xenopus
Match: kpna4 (karyopherin alpha 4 (importin alpha 3) [Source:Xenbase;Acc:XB-GENE-1011058])

HSP 1 Score: 98.9821 bits (245), Expect = 8.283e-23
Identity = 67/218 (30.73%), Postives = 113/218 (51.83%), Query Frame = 1

Query:  196 GDMLLDSTDIQIINGFKNHYANSKKWPNN-----IVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKF-QEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFACVPGENVVFKRDGGLIDYNHVTSRNDLDM--VRKFYAC 825
            G+M L      +IN  ++  ++   WP +     +V Y F+ N+  D++   + ++ E +     CV+F  +     ++ + S   GC SM+G  GG  Q + L + GCM S+G I+HE  HALGF H HMR DRD+++TI  + I+ S+ + F K +  ++   Y+ NSVMHY    F+  P ++ +  +    I        + LD+  ++K Y C
Sbjct:   49 GNMALTEGGDILINIGRSATSSDYLWPKSADGTVVVPYIFSYNYSADELTLFKTAMQEFET--LTCVRFVPKTIQRDFLNIVSNG-GCLSMVGRNGG-GQKVELASYGCM-SRGVIQHELNHALGFYHEHMRSDRDDYVTIITENIIPSYENYFSKRKTNNMGIIYDYNSVMHYSRNTFSISPDKSTIVPKPDPSIPIGQRDGLSILDILKIKKLYQC 261

[Close]

BLAST of Metalloendopeptidase vs. Ensembl Xenopus
Match: golt1b (golgi transport 1B [Source:Xenbase;Acc:XB-GENE-5753086])

HSP 1 Score: 97.8265 bits (242), Expect = 2.032e-22
Identity = 60/183 (32.79%), Postives = 97/183 (53.01%), Query Frame = 1

Query:  286 VTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGH-YIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFACVPGENVVFKRDGGLIDYNHVTSRNDLDMVR--KFYAC 825
            V YT    +  D+I T+  ++ E+   L  CV+F    +   YI + S  +GC+S +G  GG +Q +++E   C  S+GT  HE  HALGF+H H R DRDN++ I +  I +     F K E  +LD  Y+  S+MHYP++ F+   G+N +  +    +      +   LD+++  + Y C
Sbjct:   88 VPYTLDKQYSSDQINTITSAM-EVYSTL-TCVQFVPYTDEEDYIAITSG-DGCWSFMGRQGG-AQVVSVEKGYCT-SEGTTMHELNHALGFVHEHSRSDRDNYVNIMYQYISSGDDVNFEKMETNNLDTTYDYRSIMHYPAWAFSNTTGQNTIVAKPNPNVTIGAGNTMTSLDIIKINRLYEC 265

[Close]

BLAST of Metalloendopeptidase vs. Ensembl Xenopus
Match: polr2l.2 (polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa, gene 2 [Source:Xenbase;Acc:XB-GENE-5898446])

HSP 1 Score: 97.0561 bits (240), Expect = 3.649e-22
Identity = 67/210 (31.90%), Postives = 104/210 (49.52%), Query Frame = 1

Query:  220 DIQIINGFKNHYANSKKWPNNI-----VTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQE-GRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFACVPGENVVFKRDGGL--IDYNHVTSRNDLDMVRKFYAC 825
            DI I  G       S  WP +      V Y  + ++  ++  ++R +L  L+ +   CV F E      ++++ S   GC+S +G TGG +Q L+L + GC+ +KG I+HE  HALGF H   R DRD +I + W  I  S    F   +  +LD PY+ +SVMHY  Y F+   G+  +  +      I   +  S  D+  V++ Y C
Sbjct:   54 DIAIETGRSATKCPSCLWPKSADGTVRVPYRLSADYSDNEKSSIRDAL--LEFNTLTCVHFVERSTEEDFLDIVSD-SGCWSSIGRTGG-AQTLSLMSSGCL-AKGIIQHEVDHALGFYHEQSRSDRDTYIDVLWQYICESDWGSFEMVDTDNLDLPYDYSSVMHYGWYAFSNTSGQPSLRPKPDPTANIGQRYGLSPLDVSKVKELYGC 258

[Close]

BLAST of Metalloendopeptidase vs. Ensembl Xenopus
Match: ENSXETT00000022029.1 (astacin-like metalloendopeptidase [Source:NCBI gene;Acc:100496745])

HSP 1 Score: 95.1301 bits (235), Expect = 1.366e-21
Identity = 59/193 (30.57%), Postives = 97/193 (50.26%), Query Frame = 1

Query:  271 WPNN-----IVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRN-GHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFACVPGENVVFKR--DGGLIDYNHVTSRNDLDMVRKFYAC 825
            WP +     +V YT + N+   +   +R ++ E+   +  C++F    N   Y+ +    +GC+S +G  GG +Q ++L   GC++  G I+HE +H+LGF H   R DRDN+I I WD I       F+K    +L  PY+  SVMHY  + FA   G+  +  +     +I      S  D++ + + Y C
Sbjct:   24 WPRSRKGLVLVPYTLSNNYNSTERDIIRAAMDEVT--VLTCIQFVTYNNESDYLRIR-PYDGCWSYIGRVGG-AQDVSLMKTGCLH-HGVIQHELLHSLGFQHEQCRSDRDNYININWDNISHDKERNFLKMNTQNLGSPYDYLSVMHYGKFAFATNSGKPTLEPKGNPSAMIGQRVGLSSLDVEKINRLYQC 211

[Close]

BLAST of Metalloendopeptidase vs. Ensembl Xenopus
Match: tll1 (tolloid like 1 [Source:NCBI gene;Acc:493401])

HSP 1 Score: 94.3597 bits (233), Expect = 4.090e-21
Identity = 63/196 (32.14%), Postives = 95/196 (48.47%), Query Frame = 1

Query:  271 WPNNI-----VTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGHYIEVN----SKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFACVPGENVVFKRDGGLIDYNHVTSRNDLDMVR--KFYAC 825
            WP        V YT A  F   + + ++ +L EL     +C++F+       IE +        GC+S +G TGG SQ +++   GCM S G I+HE +HALGF+H H R DRDN++ I +  I     S F K    +L   Y+ +SVMHY  + F   PG+  +  +    +        + LD+ +  K Y C
Sbjct:  117 WPRATSGLVNVPYTIASVFDDSEQELIQGALNELMT--LSCIRFK----ARTIETDFLSFQSGNGCWSSVGKTGG-SQEVSVSKSGCM-SHGIIQHETLHALGFIHEHCRSDRDNYVDIIYKYISEGDRSSFTKVNSNNLGLQYDYSSVMHYGRFTFTNTPGQATIIPKPDLSVPIGQRYGVSSLDVAKLNKLYNC 304

[Close]

BLAST of Metalloendopeptidase vs. Ensembl Mouse
Match: Astl (astacin-like metalloendopeptidase (M12 family) [Source:MGI Symbol;Acc:MGI:3046414])

HSP 1 Score: 78.5666 bits (192), Expect = 6.328e-16
Identity = 46/172 (26.74%), Postives = 81/172 (47.09%), Query Frame = 1

Query:  220 DIQIINGFKNHYANSKKWPNNI-----VTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYS-KGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFA 717
            DI   + F+     + KWP  +     + +  +  + +   + +  +  E ++    C++F                GC+S +G +GG  Q ++L  P C+   +G + HE +H LGF H H R DRD +I + W+ IL      F+K    ++  PY+ +SVMHY  + F+
Sbjct:   77 DIIRPSPFRLLSVTNNKWPKGVGGFVEIPFLLSRKYDELSRRVIMDAFAEFERF--TCIRFVAYHGQRDFVSILPMAGCFSGVGRSGG-MQVVSLA-PTCLRKGRGIVLHELMHVLGFWHEHSRADRDRYIQVNWNEILPGFEINFIKSRSTNMLVPYDYSSVMHYGRFAFS 244

[Close]

BLAST of Metalloendopeptidase vs. Ensembl Mouse
Match: Tll2 (tolloid-like 2 [Source:MGI Symbol;Acc:MGI:1346044])

HSP 1 Score: 78.5666 bits (192), Expect = 7.794e-16
Identity = 65/243 (26.75%), Postives = 102/243 (41.98%), Query Frame = 1

Query:  124 ANGQCGCPRQSVKLRTRGLDNVKMGDMLLDSTDIQIINGFKNHYANSKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGHYIEVNSKRE-GCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCD---LDGPYETNSVMHYPSYGFA-CVPGENVVFKRDGG----LIDYNHVTSRNDLDMVRKFYAC 825
            +N     PR+  K  T  L N    +    +   ++     +     + WP  ++ Y   GNF   +    +Q++   +K    CV F E  +     V S R  GC S +G  GG  Q +++      +  G + HE  H +GF H H R DRD H+TI  + I       F+K E  +   L   Y+ +S+MHY    F+  V  + ++ +RD       I      S+ D+   RK Y C
Sbjct:  109 SNASIQAPRKDGKDATTFLPNPGTSNTTAKTFSARVRRATTSR--TERIWPGGVIPYVIGGNFTGTQRAIFKQAMRHWEK--HTCVTFVERTDEESFIVFSYRTCGCCSYVGRRGGGPQAISIGKNCDKF--GIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRRDDNGVRPTIGQRVRLSQGDIAQARKLYKC 345

[Close]

BLAST of Metalloendopeptidase vs. Ensembl Mouse
Match: Astl (astacin-like metalloendopeptidase (M12 family) [Source:MGI Symbol;Acc:MGI:3046414])

HSP 1 Score: 77.7962 bits (190), Expect = 8.919e-16
Identity = 46/172 (26.74%), Postives = 81/172 (47.09%), Query Frame = 1

Query:  220 DIQIINGFKNHYANSKKWPNNI-----VTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYS-KGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFA 717
            DI   + F+     + KWP  +     + +  +  + +   + +  +  E ++    C++F                GC+S +G +GG  Q ++L  P C+   +G + HE +H LGF H H R DRD +I + W+ IL      F+K    ++  PY+ +SVMHY  + F+
Sbjct:   56 DIIRPSPFRLLSVTNNKWPKGVGGFVEIPFLLSRKYDELSRRVIMDAFAEFERF--TCIRFVAYHGQRDFVSILPMAGCFSGVGRSGG-MQVVSLA-PTCLRKGRGIVLHELMHVLGFWHEHSRADRDRYIQVNWNEILPGFEINFIKSRSTNMLVPYDYSSVMHYGRFAFS 223

[Close]

BLAST of Metalloendopeptidase vs. Ensembl Mouse
Match: Astl (astacin-like metalloendopeptidase (M12 family) [Source:MGI Symbol;Acc:MGI:3046414])

HSP 1 Score: 77.7962 bits (190), Expect = 8.919e-16
Identity = 46/172 (26.74%), Postives = 81/172 (47.09%), Query Frame = 1

Query:  220 DIQIINGFKNHYANSKKWPNNI-----VTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYS-KGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFA 717
            DI   + F+     + KWP  +     + +  +  + +   + +  +  E ++    C++F                GC+S +G +GG  Q ++L  P C+   +G + HE +H LGF H H R DRD +I + W+ IL      F+K    ++  PY+ +SVMHY  + F+
Sbjct:   56 DIIRPSPFRLLSVTNNKWPKGVGGFVEIPFLLSRKYDELSRRVIMDAFAEFERF--TCIRFVAYHGQRDFVSILPMAGCFSGVGRSGG-MQVVSLA-PTCLRKGRGIVLHELMHVLGFWHEHSRADRDRYIQVNWNEILPGFEINFIKSRSTNMLVPYDYSSVMHYGRFAFS 223

[Close]

BLAST of Metalloendopeptidase vs. Ensembl Mouse
Match: Mep1a (meprin 1 alpha [Source:MGI Symbol;Acc:MGI:96963])

HSP 1 Score: 78.1814 bits (191), Expect = 1.184e-15
Identity = 68/229 (29.69%), Postives = 108/229 (47.16%), Query Frame = 1

Query:  184 NVKMGDMLLDSTDIQIINGFKNHYANSKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQ--EGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEG---CDLDGPYETNSVMHYPSYGF----------ACVPGENVVFKRDGGLIDYNHVTSRNDLDMVRKFYAC 825
            N+  GD+LL  T     N  ++    S +W   I  Y  A N   +    +  +    +  L++CV F+  EG + + I    K  GC+SM+G      Q +++   GC + K TI+HE +HALGF H   R DRD+++ I WD+I+T +   F   +     DL+ PY+  S+MHY  + F            +P  N +    G L D++ +    DL  + + Y C
Sbjct:   65 NLFQGDILLPRTR----NAMRD---PSSRWKLPI-PYILADNLELNAKGAILHAFEMFR--LKSCVDFKPYEGESSYII--FQKLSGCWSMIG-DQQVGQNISI-GEGCDF-KATIEHEILHALGFFHEQSRTDRDDYVNIWWDQIITDYEHNFNTYDDNTITDLNTPYDYESLMHYGPFSFNKNESIPTITTKIPEFNTII---GQLPDFSAI----DLIRLNRMYNC 271

[Close]

BLAST of Metalloendopeptidase vs. UniProt/SwissProt
Match: sp|P55112|NAS4_CAEEL (Zinc metalloproteinase nas-4 OS=Caenorhabditis elegans OX=6239 GN=nas-4 PE=2 SV=4)

HSP 1 Score: 102.064 bits (253), Expect = 7.413e-24
Identity = 73/230 (31.74%), Postives = 114/230 (49.57%), Query Frame = 1

Query:  178 LDNVKMGDMLLDSTDIQII-------NGFKNHYANSKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKF---QEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEG---CDLDGPYETNSVMHYPSYGFACVPGENVVFKRDGGLIDYNHVT-SRNDLDMVRKFYAC 825
            + N   GD+LL+S    +        N  K  Y   ++WPNN + YT +  +       +  ++ E     + CVKF      ++  Y+ ++   EGCYS++G TGG  QP++L++ GC+   GTI HE +HA+GF H   R+DRD++I + W  ++     QF K        LD PY+  S+MHY  Y F+    + +V K+ G       V  S  D+  + K Y C
Sbjct:   69 IGNYSEGDILLESPKKFVEENNKLGRNAIKQIY---RRWPNNEIPYTLSSQYGSYARSVIANAMNEYHT--KTCVKFVARDPSKHHDYLWIHPD-EGCYSLVGKTGG-KQPVSLDS-GCI-QVGTIVHELMHAVGFFHEQSRQDRDSYIDVVWQNVMNGADDQFEKYNLNVISHLDEPYDYASIMHYGPYAFSGSGKKTLVPKKSGSERMGQRVKFSDIDVRKINKLYNC 289

[Close]

BLAST of Metalloendopeptidase vs. UniProt/SwissProt
Match: sp|P31580|HCE1_ORYLA (High choriolytic enzyme 1 OS=Oryzias latipes OX=8090 GN=hcea PE=1 SV=1)

HSP 1 Score: 95.9005 bits (237), Expect = 6.269e-22
Identity = 60/191 (31.41%), Postives = 95/191 (49.74%), Query Frame = 1

Query:  283 IVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGH-YIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFAC---------VPGENVVFKRDGGLIDYNHVTSRNDLDMVRKFYAC 825
            ++ Y  +  +   ++ T+  ++       + C++F    N + +I V SK  GCYS LG  GG  Q L++   GCMYS G I+HE  HALGF H   R DRD+++ I W+ I+ +    F K +  +L+ PY+ +S+MHY    F+          +P  NV   +  G+       SR D+  +   Y C
Sbjct:   91 VIPYVISSEYSGGEVATIEGAMRAFNG--KTCIRFVRRTNEYDFISVVSK-TGCYSELGRKGG-QQELSINRGGCMYS-GIIQHELNHALGFQHEQTRSDRDSYVRINWENIIPASAYNFNKHDTNNLNTPYDYSSIMHYGRDAFSIAYGRDSITPIPNPNVPIGQRNGM-------SRWDITRINVLYNC 269

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BLAST of Metalloendopeptidase vs. UniProt/SwissProt
Match: sp|P31581|HCE2_ORYLA (High choriolytic enzyme 2 OS=Oryzias latipes OX=8090 GN=hceb PE=2 SV=1)

HSP 1 Score: 95.9005 bits (237), Expect = 7.271e-22
Identity = 53/154 (34.42%), Postives = 84/154 (54.55%), Query Frame = 1

Query:  283 IVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGH-YIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFACVPGENVV 741
            ++ Y  +  + + ++ T+  ++       + C++F    N + +I V SK  GCYS LG  GG  Q L+L   GCMYS G I+HE  HALGF H   R DRD+++ I W  I+ +    F K +  +L+ PY+ +S+MHY    F+   G + +
Sbjct:  100 VIPYVISSQYSRGEVATIEGAMRAFNG--RTCIRFVRRTNEYDFISVVSK-NGCYSELGRKGG-QQELSLNRGGCMYS-GIIQHELNHALGFQHEQTRSDRDSYVRINWQNIIPASAYNFNKHDTNNLNTPYDYSSIMHYGRDAFSIAYGRDSI 248

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BLAST of Metalloendopeptidase vs. UniProt/SwissProt
Match: sp|P31579|LCE_ORYLA (Low choriolytic enzyme OS=Oryzias latipes OX=8090 GN=lce PE=1 SV=1)

HSP 1 Score: 95.1301 bits (235), Expect = 1.064e-21
Identity = 69/229 (30.13%), Postives = 103/229 (44.98%), Query Frame = 1

Query:  160 KLRTRGLDNVKMGDMLLDSTDIQIINGFKNHYA-NSKKWP---NNIVT--YTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFACVPGENVV-FKRDGGLIDYNHVTSRNDLDMVRKFYAC 825
            ++    ++ +  GD++L  T     N  K   A +S +WP   N IV   Y  + N+  D+ +T+R ++ E  +  + C+ F    N         R GC SM+G  G   Q + L+  GC+     I+HE +HALGF H H R DRD H+ I W+ I+      F K +  +L  PY+  S+MHY    F     E +         I      S  D+  V K Y C
Sbjct:   51 RMNNNSMEELLEGDLVLPKTR----NAMKCFGAPDSCRWPKSSNGIVKVPYVVSDNYESDEKETIRNAMKEFAE--KTCIHFVPRNNERAYLSLEPRFGCKSMMGYVGD-KQVVVLQRFGCI-KHAVIQHELLHALGFYHEHTRSDRDQHVKINWENIIKDFTHNFDKNDTDNLGTPYDYGSIMHYGRTAFGKDRKETITPIPNPKAAIGQTERMSDIDILRVNKLYKC 271

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BLAST of Metalloendopeptidase vs. UniProt/SwissProt
Match: sp|P07584|ASTA_ASTAS (Astacin OS=Astacus astacus OX=6715 PE=1 SV=2)

HSP 1 Score: 89.3521 bits (220), Expect = 9.198e-20
Identity = 55/166 (33.13%), Postives = 89/166 (53.61%), Query Frame = 1

Query:  271 WPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKF-QEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQF-VKCEGCDLDGPYETNSVMHYPSYGFACVPG--ENVVFKRDG 756
            W   ++ YTFAG    D+   +   + EL++  + C++F        Y+E+ +   GC+S +G   G +Q ++L+  GC+Y  GTI HE +HA+GF H H R DRDN++TI +  +  S  S F +      +   Y+  S+MHY  Y F+   G  E +V  ++G
Sbjct:   59 WSGGVIPYTFAGVSGADQ-SAILSGMQELEE--KTCIRFVPRTTESDYVEIFTSGSGCWSYVGRISG-AQQVSLQANGCVY-HGTIIHELMHAIGFYHEHTRMDRDNYVTINYQNVDPSMTSNFDIDTYSRYVGEDYQYYSIMHYGKYSFSIQWGVLETIVPLQNG 219

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BLAST of Metalloendopeptidase vs. TrEMBL
Match: A0A060Q714 (Metalloendopeptidase OS=Schmidtea mediterranea OX=79327 GN=Ast2 PE=2 SV=1)

HSP 1 Score: 478.019 bits (1229), Expect = 3.054e-169
Identity = 226/250 (90.40%), Postives = 233/250 (93.20%), Query Frame = 1

Query:   76 MEKLILLLLGFVVIDYANGQCGCPRQSVKLRTRGLDNVKMGDMLLDSTDIQIINGFKNHYANSKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFACVPGENVVFKRDGGLIDYNHVTSRNDLDMVRKFYAC 825
            MEKLILLLLGFVVIDYANGQCGCPRQSVKLRTRGLDNVKMGDMLLDSTDIQIINGFKNHYANSKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTS CSQF KC+GC+ DGPYET SVMHY S GFAC P E VV K++GG I YNH T+ NDL M++ FY C
Sbjct:    1 MEKLILLLLGFVVIDYANGQCGCPRQSVKLRTRGLDNVKMGDMLLDSTDIQIINGFKNHYANSKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSQCSQFTKCDGCEPDGPYETESVMHYNSEGFACNPSEKVVVKKNGGAIGYNHETTANDLQMIKNFYNC 250

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BLAST of Metalloendopeptidase vs. TrEMBL
Match: A0A060Q786 (Metalloendopeptidase OS=Schmidtea mediterranea OX=79327 GN=Ast6 PE=2 SV=1)

HSP 1 Score: 415.231 bits (1066), Expect = 1.603e-144
Identity = 194/250 (77.60%), Postives = 214/250 (85.60%), Query Frame = 1

Query:   76 MEKLILLLLGFVVIDYANGQCGCPRQSVKLRTRGLDNVKMGDMLLDSTDIQIINGFKNHYANSKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFACVPGENVVFKRDGGLIDYNHVTSRNDLDMVRKFYAC 825
            M  L  LLL    + Y +GQCGCPRQ  KL  RGLD+++MGDM+LD +DI +INGFK HY+N+K+WPNN V ++FA  FP DK   VR+ L ELQKDL NCVKF E    HYIEV+S  +GCYS+LG TGGP+QPLNL+NPGCMYSKGT+KHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFACVPGENVVFKRDGGLIDYNHVTSRNDLDMVRKFYAC
Sbjct:    1 MRSLFCLLLIVAAVSYVSGQCGCPRQ--KLLKRGLDSMQMGDMVLDKSDIALINGFKAHYSNTKRWPNNQVLFSFAPAFPGDKKGIVRECLVELQKDLGNCVKFSESTASHYIEVHSLNQGCYSLLGYTGGPNQPLNLQNPGCMYSKGTVKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFACVPGENVVFKRDGGLIDYNHVTSRNDLDMVRKFYAC 248

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BLAST of Metalloendopeptidase vs. TrEMBL
Match: A0A060Q785 (Metalloendopeptidase OS=Schmidtea mediterranea OX=79327 GN=Ast1 PE=2 SV=1)

HSP 1 Score: 387.497 bits (994), Expect = 1.532e-133
Identity = 181/251 (72.11%), Postives = 205/251 (81.67%), Query Frame = 1

Query:   76 MEKLILLLLGFVVIDYANGQCGCPRQSVKLRTRGLDNVKMGDMLLDSTDIQIINGFKNHYANSKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGHYIEVNSKREGCYSMLGVTGG-PSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFACVPGENVVFKRDGGLIDYNHVTSRNDLDMVRKFYAC 825
            M+K+ L+ L   VI Y +GQCGCPRQ  KL  R +D++KMGDMLLD +DI +INGFKNHYAN+KKWPNN V Y+FAGNFP+DKI  VRQ LGELQ+DL NCVKF E   GHYIEVNSK+EGCYS+LG   G P+QPLNLENPGCMYSKGT+KHEFIHALGFMHTHMRKDRDNHITI W RI TS CSQF KC+GC+LDGPYET SVMHY S GFAC P E VV ++DGG I YNH T+ NDL+M+R FY C
Sbjct:    1 MQKMFLMCLAIAVIGYVSGQCGCPRQ--KLLKRSVDSMKMGDMLLDKSDIALINGFKNHYANTKKWPNNNVVYSFAGNFPRDKIPVVRQCLGELQRDLGNCVKFTESNQGHYIEVNSKQEGCYSLLGYAAGMPTQPLNLENPGCMYSKGTVKHEFIHALGFMHTHMRKDRDNHITINWARIETSQCSQFTKCDGCELDGPYETTSVMHYNSEGFACDPREKVVLRKDGGAIGYNHDTTPNDLNMIRNFYGC 249

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BLAST of Metalloendopeptidase vs. TrEMBL
Match: I1ZIC3 (Metalloendopeptidase OS=Schmidtea mediterranea OX=79327 GN=Ast3 PE=2 SV=1)

HSP 1 Score: 281.182 bits (718), Expect = 1.564e-91
Identity = 134/250 (53.60%), Postives = 172/250 (68.80%), Query Frame = 1

Query:   76 MEKLILLLLGFVVIDYANGQCGCPRQSVKLRTRGLDNVKMGDMLLDSTDIQIINGFKNHYANSKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFACVPGENVVFKRDGGLIDYNHVTSRNDLDMVRKFYAC 825
            M+K ++L++  V+ +    QCGC ++  KL TR  +N+ +GDMLL   DI IINGFK+H   ++ WP   V++ FA +FP DK   V+Q L ELQ DL NCV+F E   G +I V+++ +GCY+M+G TG   Q LNL+NP CM SKGTIKHEFIHALGFMHTHMR DRDN I+I W  I +S C  FVKCEGC +DG YET SVMHY S  F C  G N + +++G LIDYNH T+ NDL M++  Y C
Sbjct:    5 MQKFLILIV-LVLANEVASQCGCNKK--KLMTRATENLHVGDMLLSKADIAIINGFKHHQREARAWPGGKVSFAFANDFPADKRNLVKQCLNELQSDLGNCVQFFESTQGPHIAVHAQNKGCYAMIGCTGERGQFLNLQNPWCMNSKGTIKHEFIHALGFMHTHMRMDRDNFISINWRNIQSSQCFNFVKCEGCIMDGNYETRSVMHYSSDAFGCQQGMNTMIQKNGNLIDYNHNTTPNDLSMIKSLYNC 251

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BLAST of Metalloendopeptidase vs. TrEMBL
Match: A0A060Q750 (Metalloendopeptidase OS=Schmidtea mediterranea OX=79327 GN=Ast5 PE=2 SV=1)

HSP 1 Score: 229.565 bits (584), Expect = 3.515e-71
Identity = 117/254 (46.06%), Postives = 160/254 (62.99%), Query Frame = 1

Query:   73 FMEKLILLLLGFVVIDYANGQCGCPRQSVKLRTRGLDNVKMGDMLLDSTDIQIINGFKNHYANSKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGHYIEVNSKREGCYSMLGVTG--GPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFACVPGENVVF-KRDGGLIDYNHVTSRNDLDMVRKFYAC 825
            F+   +L +L  V I+   G+CGC +  +K   R + ++K+ DMLLD  D+  I GF+ +  N+++W +N + YTF   FP DK Q VR+S+ EL  DL+ CVK+ E  +G++I+V S + GC+S +G+    G SQ LNLENPGC+YSKGTIKHEFIHA GFMHT MR DRD  + I W+RI +  C  FV C+ C+    Y+TNSVMHYPS  F C PG+ +    +    I YNH T   D  M++  Y C
Sbjct:    5 FIGLFLLSILNLVFIE--AGKCGCQKSKLK---RAI-SLKIDDMLLDHVDLMKIEGFRGYDKNARRWTDNTLKYTFHPQFPADKKQIVRESMNELTNDLKGCVKYVESTSGYHIKVQSHQPGCWSFVGMLNKQGGSQELNLENPGCLYSKGTIKHEFIHATGFMHTQMRADRDKFVNIFWERIDSDFCHAFVTCKNCEETVTYKTNSVMHYPSESFPC-PGQRITMVDKQNKEIPYNHGTIEEDHQMIKHLYQC 251

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BLAST of Metalloendopeptidase vs. Ensembl Cavefish
Match: ENSAMXT00000050470.1 (low choriolytic enzyme-like [Source:NCBI gene;Acc:103035835])

HSP 1 Score: 104.76 bits (260), Expect = 2.346e-26
Identity = 64/199 (32.16%), Postives = 98/199 (49.25%), Query Frame = 1

Query:  271 WPNN-----IVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGH-YIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFA--------CVPGENVVFKRDGGLIDYNHVTSRNDLDMVRKFYAC 825
            WP +      V Y  +  F   ++Q +++ L        +C++F+   N   YI + S R GCYS +G  G  +Q ++L+  GC+Y   T++HE +HALGF H   R DRDNHI + WD I+ S    F K    +   PY+ NSVM Y    F+         +P  NV F +   +       S+ND++ + + Y C
Sbjct:   72 WPKSSDGKVYVPYIISNQFASRELQVIQRGLDSFSS--MSCIRFKRRSNERDYISIES-RSGCYSYIGRLGN-AQTVSLDRNGCIY-HNTVQHELLHALGFNHEQTRSDRDNHIRVVWDNIIDSMKHNFNKIATLNQGTPYDYNSVMQYHRTAFSKNGQPTMVPIPNSNVSFGQASQM-------SQNDINRLNRLYKC 258

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BLAST of Metalloendopeptidase vs. Ensembl Cavefish
Match: ENSAMXT00000021327.2 (low choriolytic enzyme-like [Source:NCBI gene;Acc:103035835])

HSP 1 Score: 104.76 bits (260), Expect = 3.251e-26
Identity = 64/199 (32.16%), Postives = 98/199 (49.25%), Query Frame = 1

Query:  271 WPNN-----IVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGH-YIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFA--------CVPGENVVFKRDGGLIDYNHVTSRNDLDMVRKFYAC 825
            WP +      V Y  +  F   ++Q +++ L        +C++F+   N   YI + S R GCYS +G  G  +Q ++L+  GC+Y   T++HE +HALGF H   R DRDNHI + WD I+ S    F K    +   PY+ NSVM Y    F+         +P  NV F +   +       S+ND++ + + Y C
Sbjct:   61 WPKSSDGKVYVPYIISNQFASRELQVIQRGLDSFSS--MSCIRFKRRSNERDYISIES-RSGCYSYIGRLGN-AQTVSLDRNGCIY-HNTVQHELLHALGFNHEQTRSDRDNHIRVVWDNIIDSMKHNFNKIATLNQGTPYDYNSVMQYHRTAFSKNGQPTMVPIPNSNVSFGQASQM-------SQNDINRLNRLYKC 247

[Close]

BLAST of Metalloendopeptidase vs. Ensembl Cavefish
Match: c6ast1 (low choriolytic enzyme-like [Source:NCBI gene;Acc:111191947])

HSP 1 Score: 102.834 bits (255), Expect = 1.476e-25
Identity = 79/235 (33.62%), Postives = 114/235 (48.51%), Query Frame = 1

Query:  184 NVKMGDMLLDST----DIQIINGFKN-HYANSKK----WP-----NNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQ-EGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFA--------CVPGENVVFKRDGGLIDYNHVTSRNDLDMVRKFY 819
            N  +G  L D T    DI + +G +N     S+K    WP     N  + Y  +  F  ++   +   L   +K    C++F+   R   YI+V S  EGCYS +G TGG  Q L+L++ GC+Y K  I+HEF+HALGF H   R DRD HI I ++ I       F K +  +L+ PY+  SVMHY    F+         +P +NV   R   +       S ND+  ++K Y
Sbjct:   43 NRNIGQTLEDPTIRFGDILVDDGLQNADRCTSRKPSCMWPMNSDGNTYIPYIISNQFSPNEKDLITSVLKTFEK--STCIRFKPRDREEDYIDVQS-LEGCYSFVGRTGG-RQTLSLKSRGCLYKK-IIQHEFLHALGFHHEQCRSDRDKHIRILYENIDPGKEHNFDKKDTNNLNTPYDYGSVMHYGRDAFSRNGQPTMVPIPNQNVAVGRAEEM-------SANDILRIKKLY 265

[Close]

BLAST of Metalloendopeptidase vs. Ensembl Cavefish
Match: c6ast1 (low choriolytic enzyme-like [Source:NCBI gene;Acc:111191947])

HSP 1 Score: 102.834 bits (255), Expect = 1.982e-25
Identity = 79/235 (33.62%), Postives = 114/235 (48.51%), Query Frame = 1

Query:  184 NVKMGDMLLDST----DIQIINGFKN-HYANSKK----WP-----NNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQ-EGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFA--------CVPGENVVFKRDGGLIDYNHVTSRNDLDMVRKFY 819
            N  +G  L D T    DI + +G +N     S+K    WP     N  + Y  +  F  ++   +   L   +K    C++F+   R   YI+V S  EGCYS +G TGG  Q L+L++ GC+Y K  I+HEF+HALGF H   R DRD HI I ++ I       F K +  +L+ PY+  SVMHY    F+         +P +NV   R   +       S ND+  ++K Y
Sbjct:   54 NRNIGQTLEDPTIRFGDILVDDGLQNADRCTSRKPSCMWPMNSDGNTYIPYIISNQFSPNEKDLITSVLKTFEK--STCIRFKPRDREEDYIDVQS-LEGCYSFVGRTGG-RQTLSLKSRGCLYKK-IIQHEFLHALGFHHEQCRSDRDKHIRILYENIDPGKEHNFDKKDTNNLNTPYDYGSVMHYGRDAFSRNGQPTMVPIPNQNVAVGRAEEM-------SANDILRIKKLY 276

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BLAST of Metalloendopeptidase vs. Ensembl Cavefish
Match: c6ast3 (six-cysteine containing astacin protease 3 [Source:ZFIN;Acc:ZDB-GENE-050320-99])

HSP 1 Score: 102.449 bits (254), Expect = 2.578e-25
Identity = 63/199 (31.66%), Postives = 98/199 (49.25%), Query Frame = 1

Query:  271 WPNN-----IVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGH-YIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFA--------CVPGENVVFKRDGGLIDYNHVTSRNDLDMVRKFYAC 825
            WP +      V Y  +  F   ++Q +++ L        +C++F+   N   Y+ + S R GCYS +G  G  +Q ++L   GC+Y K T++HE +HALGF H   R DRDNHI + W+ I+ +    F K    +   PY+ NSVM Y    F+         +P  NV F +   +       S+ND+  ++K Y C
Sbjct:   61 WPKSNDGKVYVPYVISNQFASREVQVIQRGLDSFSS--FSCIRFKRRTNERDYLSIES-RNGCYSYVGRRGN-AQTVSLARNGCIYHK-TVQHELLHALGFNHEQTRSDRDNHIRVAWENIVDTMKHNFNKIATLNQGTPYDYNSVMQYHKTAFSKNGKPTMIPIPNANVAFGQATQM-------SQNDITRLKKLYKC 247

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BLAST of Metalloendopeptidase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007253.1 (pep scaffold:Pmarinus_7.0:GL476910:54360:144194:-1 gene:ENSPMAG00000006538.1 transcript:ENSPMAT00000007253.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 78.5666 bits (192), Expect = 1.389e-16
Identity = 58/198 (29.29%), Postives = 89/198 (44.95%), Query Frame = 1

Query:  259 NSKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGH-YIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDG---PYETNSVMHYPSYGFACVPGENVVFKR--DGGL---IDYNHVTSRNDLDMVRKFYAC 825
            + + WP  ++ Y   GNF   +    RQ++   +K    CV F E  +   YI    +  GC S +G  GG  Q +++      +  G + HE  H +GF H H R DRD+H+TI    I       F+K E  ++D     Y+ +S+MHY    F+     + +  R  D G+   I      S+ D+   RK Y C
Sbjct:   18 SERIWPGGVIPYIVGGNFTGSQKAMFRQAMRHWEK--HTCVTFIERTDEESYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKF--GIVVHELGHVIGFWHEHTRPDRDDHVTIIKANIQPGQEYNFLKMEPGEVDSLGESYDFDSIMHYARNTFSRGIFLDTILPRPDDSGVRPAIGQRTRLSQGDIAQARKLYRC 211

[Close]

BLAST of Metalloendopeptidase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004913.1 (pep scaffold:Pmarinus_7.0:GL478359:22377:26907:1 gene:ENSPMAG00000004462.1 transcript:ENSPMAT00000004913.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 50.447 bits (119), Expect = 5.499e-8
Identity = 33/95 (34.74%), Postives = 47/95 (49.47%), Query Frame = 1

Query:  439 CYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDG-PYETNSVMHYPSYGFAC 720
            C+S +G+ G   Q +++   GC    GT+ HE  HA+G++H   R DRD  I++    +      QF      D  G PY+  SVMHY     AC
Sbjct:    1 CWSFVGMIGVGEQVVSIGR-GCE-GVGTVAHELGHAVGYVHEQSRPDRDAFISVLEGNVQDGQLPQFAVYSATDPRGVPYDLKSVMHYSRNVRAC 93

[Close]

BLAST of Metalloendopeptidase vs. Ensembl Nematostella
Match: EDO34721 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SNJ4])

HSP 1 Score: 95.5153 bits (236), Expect = 3.483e-23
Identity = 71/217 (32.72%), Postives = 104/217 (47.93%), Query Frame = 1

Query:  196 GDMLLDSTDIQIINGFKNHYANS-----KKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRN-GHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLD---GPYETNSVMHYPSYGFACVPGENVVFKRDGGLIDYNHVTSRNDLDMVRKFY 819
            GD+ LDS+  +I++   +    +       WPN  + Y F G       +  R ++ E + +   C++F E  +   YI V S+  GC+S +G +GG  Q L+L        KGT  HE +H LGF H   R+DRDN+ITI WD I +     F K E   +D    PY+  S+MHYP + F+      +V K     I      S+ DL  + K Y
Sbjct:    4 GDIYLDSSTTRIMDQLMSPSREALVDPVSHWPNGRLPYKF-GAVSNSVKEAFRAAIDEYEAN--TCIRFVERTDETDYILVVSE-GGCWSPIGRSGG-QQKLSLGT--YCDRKGTAMHELMHTLGFFHEQSRRDRDNYITIHWDNIQSDKQFNFQKYEHGKVDTLGAPYDYGSIMHYPMFAFSSNGRATIVPKDPTASIGQRSGFSKVDLQQLNKLY 213

[Close]

BLAST of Metalloendopeptidase vs. Ensembl Nematostella
Match: EDO41420 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4I5])

HSP 1 Score: 89.3521 bits (220), Expect = 2.572e-21
Identity = 56/189 (29.63%), Postives = 90/189 (47.62%), Query Frame = 1

Query:  268 KWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRI---LTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFACVPGENVVFKRDGGLIDYNHVTSRNDLDMVRKFYAC 825
            +WP  ++ YT   +     +  +R  + ++  D   C++F+E  N +      +  GC SM+G TG   Q ++L   GC Y  GT+ HE  HALGF H   R DRDN++TI W+ I   +  + + + +     L  PY+  SVMHY    F+      +  K+ G  +      S+ D+  +   Y C
Sbjct:   40 RWPEGVMAYTIDRSLSNRAMNAIRAGM-KMWTD-NTCIRFKERTNEYAYARFWRGRGCSSMVGRTG-RRQDISLAG-GCWY-PGTVAHEIGHALGFYHEQSRPDRDNYVTIHWNNISPNMKFNFNMYPRSTIDSLGTPYDYRSVMHYQGNAFSSNGRATITAKQSGVTLGNRRQLSKVDIQQMNLMYKC 223

[Close]

BLAST of Metalloendopeptidase vs. Ensembl Nematostella
Match: EDO37770 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SEU5])

HSP 1 Score: 90.5077 bits (223), Expect = 3.885e-21
Identity = 65/218 (29.82%), Postives = 99/218 (45.41%), Query Frame = 1

Query:  196 GDMLLDSTDIQIIN-----GFKNHYANSKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLD---GPYETNSVMHYPSYGFACVPGENVVFKRDGGLIDYNHVTSRNDLDMVRKFYAC 825
            GDM+L     Q +N       +    + KKWPN I+ Y    +      + V Q+    + + + CV+FQ+           K +GC+S +G+    +Q ++L   GC + KGT  HE  HALGF H   R DRDN++T+ WD I T     F K     ++    PY+  S+MHY +  F+      +  K+ G  I      S  D+  +   Y C
Sbjct:   34 GDMILTPDQQQAVNNGDLGASRGAPIHDKKWPNAILPYEIRSDLKGTPAEGVIQN-AMREWESKTCVRFQKRTTQKNYVYFFKGDGCWSYVGMLDRGAQAISL-GSGC-WHKGTAAHEIGHALGFYHEQSRPDRDNYVTVHWDNIKTDSKHNFNKYSADRINTFGTPYDFGSLMHYGTNYFSVNGRATITPKKSGAKIGQRDYLSDLDVHQMNLRYGC 248

[Close]

BLAST of Metalloendopeptidase vs. Ensembl Nematostella
Match: EDO42421 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S1T1])

HSP 1 Score: 86.6557 bits (213), Expect = 1.707e-20
Identity = 61/194 (31.44%), Postives = 95/194 (48.97%), Query Frame = 1

Query:  265 KKWPNNIVTYTFAGNFPQDK--IQTVRQSLGELQKDLQNCVKFQE--GRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDG---PYETNSVMHYPSYGFACVPGENVVFKRDGGLIDYNHVTSRNDLDMVRKFYAC 825
            K WP  +V Y     F +    ++ + Q++ + +K    C++F++    +  Y+ +   R GC S +G  GG  Q L+L + GC + KGTI HE  HALGF H   R DRD+++TI ++ I     S F+K    ++D    PY+  S+MHY    F+      +V K+ G         S  D+  V   Y C
Sbjct:   10 KLWPGGVVVYELDPRFERSSRAMEKLTQAISDYEK--YTCIRFRKKTANDNDYVYIKD-RGGCRSHVGRKGG-KQYLSLSS-GC-WHKGTIIHELGHALGFFHEQTRPDRDDYVTILFENIRLGMASNFMKHSAGEVDSLGTPYDYGSIMHYGPKIFSANGKPTIVAKKPGVKFGQRDGLSPIDIKQVNLLYKC 197

[Close]

BLAST of Metalloendopeptidase vs. Ensembl Nematostella
Match: EDO30445 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T0S0])

HSP 1 Score: 85.1149 bits (209), Expect = 1.771e-19
Identity = 66/217 (30.41%), Postives = 107/217 (49.31%), Query Frame = 1

Query:  184 NVKMGDMLLDSTDIQIINGFKNHYAN-SKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGH-YIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRI---LTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFACVPGENVVFKRDGGLIDYNHVTSRNDLDMVRKFY 819
            +V  GD+ LD +   I+   ++  ++ ++ W N  V Y F G+   +       ++ E +   + CV+F   R    YI + S+  GC+S +G +GG  Q L+L   GC + +GT  HE +HA+GF H   R DRD++ITI WD I   +  +  ++ + E   L   Y+  S+MHYP Y F     +  +  R+G  I      S  D+  +   Y
Sbjct:    1 DVFEGDIYLDRSTKAILGMGRDAMSSPARHWLNARVPYVF-GSVSSEVRSVFLAAIKEYEA--KTCVRFVPRRGERDYIYIVSE-GGCFSSIGRSGG-LQKLSL-GTGCEH-RGTAIHEMMHAIGFFHEQSRLDRDSYITIYWDNIKPGMEYNFRKYKRGEADTLGYAYDLKSIMHYPKYAFT-KNRQPTIIARNGANIGQRDSFSAIDIQQINALY 209

[Close]

BLAST of Metalloendopeptidase vs. Ensembl Medaka
Match: mc6ast5 (astacin like metallo-protease [Source:NCBI gene;Acc:100049509])

HSP 1 Score: 109.383 bits (272), Expect = 6.551e-28
Identity = 66/195 (33.85%), Postives = 98/195 (50.26%), Query Frame = 1

Query:  256 ANSKKWPNNIVTYTFAGNFPQ---DKIQTVRQSLGELQKDLQNCVKF-QEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFACVPGENVVFKRDGGL-IDYNHVTSRNDLDMVRKFYAC 825
             N+  WP ++  + +         D +  +    G        C+KF       H++++   R GC+S LG TGG SQ L+L+ PGCM+S G   HEF+HALGF+H   R DRD+++TI W  I+  H   F K    +L+ PY+ +SVMHY  Y F+   G  ++ + D  + I      S  DL  +   Y C
Sbjct:   88 GNTCLWPKSVDGFVYVPYIVSPLYDDMDRITIETGMQDIASGTCIKFVPRTHEAHFLDIQ-PRYGCWSFLGQTGG-SQTLSLQTPGCMWS-GIAAHEFMHALGFVHEQSRSDRDHYVTIVWKNIMPDHAHNFRKQATNNLNSPYDYSSVMHYGRYAFSGDGGPTIIPRPDPYIPIGQRDGPSALDLHKINVLYDC 279

[Close]

BLAST of Metalloendopeptidase vs. Ensembl Medaka
Match: mc6ast4 (astacin like metallo-protease [Source:NCBI gene;Acc:100049317])

HSP 1 Score: 103.99 bits (258), Expect = 7.145e-26
Identity = 64/220 (29.09%), Postives = 113/220 (51.36%), Query Frame = 1

Query:  196 GDMLLDSTDIQIINGFKNH--YANSKKWPNNI-----VTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKF-QEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFACVPGENVVFKRDGGLIDYNHVTSRNDLDMVR--KFYAC 825
            G   L   DI +  G ++   +A S  W  ++     + YT + ++ +  ++ +++ +  +++    CV+F  +     Y+++  K  GC+S LG  GG  Q L+L+NP CM   G I HEF+HALGF+H   R DRDN+IT+ W  I       F K +   LD PY+  S+MH+  Y ++ + G+  +  ++   +     +S +  D ++  + Y C
Sbjct:   62 GTTTLREGDIAVSTGRRSKMCFARSCLWSKSVDGHVYIAYTISPDYTEADVKLIKKGMENIEEG--TCVRFVPQTHQRDYVDIQPK-SGCWSYLGARGG-RQTLSLQNPDCM-QVGVISHEFMHALGFVHEQSRFDRDNYITVMWPNIWRDRLRNFEKFKTDSLDLPYDYGSIMHFGMYAYS-MDGQPTLVAKNNRNMKLGQASSLSHTDKLKINRLYQC 275

[Close]

BLAST of Metalloendopeptidase vs. Ensembl Medaka
Match: mc6ast2 (astacin like metallo-protease [Source:NCBI gene;Acc:100049316])

HSP 1 Score: 102.064 bits (253), Expect = 3.490e-25
Identity = 57/161 (35.40%), Postives = 86/161 (53.42%), Query Frame = 1

Query:  373 NCVKFQEGRNG--HYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFA--------CVPGENVVFKRDGGLIDYNHVTSRNDLDMVRKFYAC 825
            +C++F+  +NG   ++ + S R GCYS +G  GG  Q ++L   GC+Y   T++HE +HALGF H   R DRDNHI + W+ I+      F K +  +   PY+ NSVM Y  Y F+         +P  NV F +   +       S+ND+D + + Y C
Sbjct:  118 SCIRFRPYQNGDHEWLSIES-RNGCYSYVGRQGG-GQTVSLSRQGCLY-HSTVQHELLHALGFNHEQTRSDRDNHIKVHWENIIDDMEYNFYKIDTLNQGTPYDYNSVMQYERYAFSKNNLPTMEPIPDSNVSFGQATQM-------SKNDIDRLNRLYNC 268

[Close]

BLAST of Metalloendopeptidase vs. Ensembl Medaka
Match: mc6ast2 (astacin like metallo-protease [Source:NCBI gene;Acc:100049316])

HSP 1 Score: 100.523 bits (249), Expect = 1.539e-24
Identity = 57/161 (35.40%), Postives = 86/161 (53.42%), Query Frame = 1

Query:  373 NCVKFQEGRNG--HYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFA--------CVPGENVVFKRDGGLIDYNHVTSRNDLDMVRKFYAC 825
            +C++F+  +NG   ++ + S R GCYS +G  GG  Q ++L   GC+Y   T++HE +HALGF H   R DRDNHI + W+ I+      F K +  +   PY+ NSVM Y  Y F+         +P  NV F +   +       S+ND+D + + Y C
Sbjct:  141 SCIRFRPYQNGDHEWLSIES-RNGCYSYVGRQGG-GQTVSLSRQGCLY-HSTVQHELLHALGFNHEQTRSDRDNHIKVHWENIIDDMEYNFYKIDTLNQGTPYDYNSVMQYERYAFSKNNLPTMEPIPDSNVSFGQATQM-------SKNDIDRLNRLYNC 291

[Close]

BLAST of Metalloendopeptidase vs. Ensembl Medaka
Match: mnep (nephrosin [Source:NCBI gene;Acc:100049315])

HSP 1 Score: 98.2117 bits (243), Expect = 9.817e-24
Identity = 71/235 (30.21%), Postives = 112/235 (47.66%), Query Frame = 1

Query:  184 NVKMG----DMLLDSTDIQIINGFKNHYANSKK---WP-----NNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGH-YIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFA--------CVPGENVVFKRDGGLIDYNHVTSRNDLDMVRKFYAC 825
            NV +G    D L+   DI +  G +N    + +   WP     N  V +  +G F   +  T+ Q L   +     C++F   ++   ++++ S R GC+S +G  GG  Q ++L   GC++  GTI+HE +HALGF H   R DRD+H+ I    +++     F K E  +L  PY+ NS+MHY  + F+         +P  NV   R   +       S ND+  V + Y C
Sbjct:   51 NVNIGKNLDDPLVMFGDIAVPTGLQNADPCTARGCLWPKSSDGNVYVPFRISGQFSSRERDTILQGLRSFEGS--TCIRFTPHQSQRDFVDIQS-RTGCWSFVGRRGG-GQVVSLMRQGCVF-MGTIQHELLHALGFNHEQTRSDRDSHVRILLQNVISGQEHNFRKIETRNLGTPYDYNSIMHYGRFAFSRNREPTIVPIPDPNVPIGRATEM-------SSNDILRVNRLYEC 273

[Close]

BLAST of Metalloendopeptidase vs. Planmine SMEST
Match: SMESG000072807.1 (SMESG000072807.1)

HSP 1 Score: 430.254 bits (1105), Expect = 4.656e-154
Identity = 204/238 (85.71%), Postives = 212/238 (89.08%), Query Frame = 1

Query:  112 VIDYANGQCGCPRQSVKLRTRGLDNVKMGDMLLDSTDIQIINGFKNHYANSKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFACVPGENVVFKRDGGLIDYNHVTSRNDLDMVRKFYAC 825
            +I Y      C  QSVKLRTRGLDNVKMGDMLLDSTDIQIINGFKNHYANSKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTS CSQF KC+GC+ DGPYET SVMHY S GFAC P E VV K++GG I YNH T+ NDL M++ FY C
Sbjct:    7 IIYYYQASSFCLIQSVKLRTRGLDNVKMGDMLLDSTDIQIINGFKNHYANSKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSQCSQFTKCDGCEPDGPYETESVMHYNSEGFACNPSEKVVVKKNGGAIGYNHETTANDLQMIKNFYNC 244

[Close]

BLAST of Metalloendopeptidase vs. Planmine SMEST
Match: SMESG000072805.1 (SMESG000072805.1)

HSP 1 Score: 430.254 bits (1105), Expect = 4.656e-154
Identity = 204/238 (85.71%), Postives = 212/238 (89.08%), Query Frame = 1

Query:  112 VIDYANGQCGCPRQSVKLRTRGLDNVKMGDMLLDSTDIQIINGFKNHYANSKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFACVPGENVVFKRDGGLIDYNHVTSRNDLDMVRKFYAC 825
            +I Y      C  QSVKLRTRGLDNVKMGDMLLDSTDIQIINGFKNHYANSKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTS CSQF KC+GC+ DGPYET SVMHY S GFAC P E VV K++GG I YNH T+ NDL M++ FY C
Sbjct:    7 IIYYYQASSFCLIQSVKLRTRGLDNVKMGDMLLDSTDIQIINGFKNHYANSKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSQCSQFTKCDGCEPDGPYETESVMHYNSEGFACNPSEKVVVKKNGGAIGYNHETTANDLQMIKNFYNC 244

[Close]

BLAST of Metalloendopeptidase vs. Planmine SMEST
Match: SMESG000072807.1 (SMESG000072807.1)

HSP 1 Score: 429.869 bits (1104), Expect = 7.506e-154
Identity = 204/238 (85.71%), Postives = 212/238 (89.08%), Query Frame = 1

Query:  112 VIDYANGQCGCPRQSVKLRTRGLDNVKMGDMLLDSTDIQIINGFKNHYANSKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFACVPGENVVFKRDGGLIDYNHVTSRNDLDMVRKFYAC 825
            +I Y      C  QSVKLRTRGLDNVKMGDMLLDSTDIQIINGFKNHYANSKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTS CSQF KC+GC+ DGPYET SVMHY S GFAC P E VV K++GG I YNH T+ NDL M++ FY C
Sbjct:    9 IIYYYQASSFCLIQSVKLRTRGLDNVKMGDMLLDSTDIQIINGFKNHYANSKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSQCSQFTKCDGCEPDGPYETESVMHYNSEGFACNPSEKVVVKKNGGAIGYNHETTANDLQMIKNFYNC 246

[Close]

BLAST of Metalloendopeptidase vs. Planmine SMEST
Match: SMESG000072805.1 (SMESG000072805.1)

HSP 1 Score: 429.869 bits (1104), Expect = 7.506e-154
Identity = 204/238 (85.71%), Postives = 212/238 (89.08%), Query Frame = 1

Query:  112 VIDYANGQCGCPRQSVKLRTRGLDNVKMGDMLLDSTDIQIINGFKNHYANSKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFACVPGENVVFKRDGGLIDYNHVTSRNDLDMVRKFYAC 825
            +I Y      C  QSVKLRTRGLDNVKMGDMLLDSTDIQIINGFKNHYANSKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTS CSQF KC+GC+ DGPYET SVMHY S GFAC P E VV K++GG I YNH T+ NDL M++ FY C
Sbjct:    9 IIYYYQASSFCLIQSVKLRTRGLDNVKMGDMLLDSTDIQIINGFKNHYANSKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSQCSQFTKCDGCEPDGPYETESVMHYNSEGFACNPSEKVVVKKNGGAIGYNHETTANDLQMIKNFYNC 246

[Close]

BLAST of Metalloendopeptidase vs. Planmine SMEST
Match: SMESG000072807.1 (SMESG000072807.1)

HSP 1 Score: 421.009 bits (1081), Expect = 2.068e-150
Identity = 202/238 (84.87%), Postives = 210/238 (88.24%), Query Frame = 1

Query:  112 VIDYANGQCGCPRQSVKLRTRGLDNVKMGDMLLDSTDIQIINGFKNHYANSKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVMHYPSYGFACVPGENVVFKRDGGLIDYNHVTSRNDLDMVRKFYAC 825
            +I Y      C  QSVKLRTRGLDNVKMGDMLLDSTDIQIING  NHYANSKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTS CSQF KC+GC+ DGPYET SVMHY S GFAC P E VV K++GG I YNH T+ NDL M++ FY C
Sbjct:    7 IIYYYQASSFCLIQSVKLRTRGLDNVKMGDMLLDSTDIQIING--NHYANSKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQNCVKFQEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTIKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSQCSQFTKCDGCEPDGPYETESVMHYNSEGFACNPSEKVVVKKNGGAIGYNHETTANDLQMIKNFYNC 242

The following BLAST results are available for this feature:

BLAST of Metalloendopeptidase vs. Ensembl Human
BLAST of Metalloendopeptidase vs. Ensembl Celegans
BLAST of Metalloendopeptidase vs. Ensembl Fly
BLAST of Metalloendopeptidase vs. Ensembl Zebrafish
BLAST of Metalloendopeptidase vs. Ensembl Xenopus
BLAST of Metalloendopeptidase vs. Ensembl Mouse
BLAST of Metalloendopeptidase vs. UniProt/SwissProt
BLAST of Metalloendopeptidase vs. TrEMBL
BLAST of Metalloendopeptidase vs. Ensembl Cavefish
BLAST of Metalloendopeptidase vs. Ensembl Sea Lamprey
BLAST of Metalloendopeptidase vs. Ensembl Yeast
BLAST of Metalloendopeptidase vs. Ensembl Nematostella
BLAST of Metalloendopeptidase vs. Ensembl Medaka
BLAST of Metalloendopeptidase vs. Planmine SMEST

BLAST of Metalloendopeptidase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ASTL	1.058e-18	28.19	astacin like metalloendopeptidase [Source:HGNC Sym...	[more]
TLL2	2.458e-15	29.90	tolloid like 2 [Source:HGNC Symbol;Acc:HGNC:11844]	[more]
MEP1A	5.395e-15	33.13	meprin A subunit alpha [Source:HGNC Symbol;Acc:HGN...	[more]
MEP1A	5.426e-15	33.13	meprin A subunit alpha [Source:HGNC Symbol;Acc:HGN...	[more]
TLL1	7.652e-15	27.78	tolloid like 1 [Source:HGNC Symbol;Acc:HGNC:11843]	[more]

BLAST of Metalloendopeptidase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
nas-4	5.827e-25	31.74	Zinc metalloproteinase nas-4 [Source:UniProtKB/Sw...	[more]
nas-4	1.350e-24	31.74	Zinc metalloproteinase nas-4 [Source:UniProtKB/Sw...	[more]
nas-4	1.384e-24	31.74	Zinc metalloproteinase nas-4 [Source:UniProtKB/Sw...	[more]
nas-6	2.354e-20	33.01	Zinc metalloproteinase nas-6 [Source:UniProtKB/Sw...	[more]
nas-14	6.696e-19	31.61	Zinc metalloproteinase nas-14 [Source:UniProtKB/S...	[more]

BLAST of Metalloendopeptidase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
CG6763	3.979e-32	35.23	gene:FBgn0039069 transcript:FBtr0084378	[more]
CG6763	3.979e-32	35.23	gene:FBgn0039069 transcript:FBtr0334497	[more]
CG15255	4.372e-22	30.43	gene:FBgn0028950 transcript:FBtr0080785	[more]
CG15255	4.372e-22	30.43	gene:FBgn0028950 transcript:FBtr0343719	[more]
CG11865	1.302e-21	27.56	gene:FBgn0028947 transcript:FBtr0080753	[more]

BLAST of Metalloendopeptidase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
hce2l1	1.109e-25	34.12	high choriolytic enzyme 2-like 1 [Source:ZFIN;Acc:...	[more]
hce2l1	2.970e-25	34.88	high choriolytic enzyme 2-like 1 [Source:ZFIN;Acc:...	[more]
hce2l2	1.101e-24	30.20	high choriolytic enzyme 2-like 2 [Source:ZFIN;Acc:...	[more]
hce2l2	7.990e-24	29.85	high choriolytic enzyme 2-like 2 [Source:ZFIN;Acc:...	[more]
he1.2	5.430e-23	33.17	hatching enzyme 1, tandem dupliate 2 [Source:ZFIN;...	[more]

BLAST of Metalloendopeptidase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
kpna4	8.283e-23	30.73	karyopherin alpha 4 (importin alpha 3) [Source:Xen...	[more]
golt1b	2.032e-22	32.79	golgi transport 1B [Source:Xenbase;Acc:XB-GENE-575...	[more]
polr2l.2	3.649e-22	31.90	polymerase (RNA) II (DNA directed) polypeptide L, ...	[more]
ENSXETT00000022029.1	1.366e-21	30.57	astacin-like metalloendopeptidase [Source:NCBI gen...	[more]
tll1	4.090e-21	32.14	tolloid like 1 [Source:NCBI gene;Acc:493401]	[more]

BLAST of Metalloendopeptidase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Astl	6.328e-16	26.74	astacin-like metalloendopeptidase (M12 family) [So...	[more]
Tll2	7.794e-16	26.75	tolloid-like 2 [Source:MGI Symbol;Acc:MGI:1346044]	[more]
Astl	8.919e-16	26.74	astacin-like metalloendopeptidase (M12 family) [So...	[more]
Astl	8.919e-16	26.74	astacin-like metalloendopeptidase (M12 family) [So...	[more]
Mep1a	1.184e-15	29.69	meprin 1 alpha [Source:MGI Symbol;Acc:MGI:96963]	[more]

BLAST of Metalloendopeptidase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|P55112\|NAS4_CAEEL	7.413e-24	31.74	Zinc metalloproteinase nas-4 OS=Caenorhabditis ele...	[more]
sp\|P31580\|HCE1_ORYLA	6.269e-22	31.41	High choriolytic enzyme 1 OS=Oryzias latipes OX=80...	[more]
sp\|P31581\|HCE2_ORYLA	7.271e-22	34.42	High choriolytic enzyme 2 OS=Oryzias latipes OX=80...	[more]
sp\|P31579\|LCE_ORYLA	1.064e-21	30.13	Low choriolytic enzyme OS=Oryzias latipes OX=8090 ...	[more]
sp\|P07584\|ASTA_ASTAS	9.198e-20	33.13	Astacin OS=Astacus astacus OX=6715 PE=1 SV=2	[more]

BLAST of Metalloendopeptidase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A060Q714	3.054e-169	90.40	Metalloendopeptidase OS=Schmidtea mediterranea OX=...	[more]
A0A060Q786	1.603e-144	77.60	Metalloendopeptidase OS=Schmidtea mediterranea OX=...	[more]
A0A060Q785	1.532e-133	72.11	Metalloendopeptidase OS=Schmidtea mediterranea OX=...	[more]
I1ZIC3	1.564e-91	53.60	Metalloendopeptidase OS=Schmidtea mediterranea OX=...	[more]
A0A060Q750	3.515e-71	46.06	Metalloendopeptidase OS=Schmidtea mediterranea OX=...	[more]

BLAST of Metalloendopeptidase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSAMXT00000050470.1	2.346e-26	32.16	low choriolytic enzyme-like [Source:NCBI gene;Acc:...	[more]
ENSAMXT00000021327.2	3.251e-26	32.16	low choriolytic enzyme-like [Source:NCBI gene;Acc:...	[more]
c6ast1	1.476e-25	33.62	low choriolytic enzyme-like [Source:NCBI gene;Acc:...	[more]
c6ast1	1.982e-25	33.62	low choriolytic enzyme-like [Source:NCBI gene;Acc:...	[more]
c6ast3	2.578e-25	31.66	six-cysteine containing astacin protease 3 [Source...	[more]

BLAST of Metalloendopeptidase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2


Match Name	E-value	Identity	Description
ENSPMAT00000007253.1	1.389e-16	29.29	pep scaffold:Pmarinus_7.0:GL476910:54360:144194:-1...	[more]
ENSPMAT00000004913.1	5.499e-8	34.74	pep scaffold:Pmarinus_7.0:GL478359:22377:26907:1 g...	[more]

BLAST of Metalloendopeptidase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Metalloendopeptidase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO34721	3.483e-23	32.72	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO41420	2.572e-21	29.63	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO37770	3.885e-21	29.82	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO42421	1.707e-20	31.44	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO30445	1.771e-19	30.41	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Metalloendopeptidase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
mc6ast5	6.551e-28	33.85	astacin like metallo-protease [Source:NCBI gene;Ac...	[more]
mc6ast4	7.145e-26	29.09	astacin like metallo-protease [Source:NCBI gene;Ac...	[more]
mc6ast2	3.490e-25	35.40	astacin like metallo-protease [Source:NCBI gene;Ac...	[more]
mc6ast2	1.539e-24	35.40	astacin like metallo-protease [Source:NCBI gene;Ac...	[more]
mnep	9.817e-24	30.21	nephrosin [Source:NCBI gene;Acc:100049315]	[more]

BLAST of Metalloendopeptidase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000072807.1	4.656e-154	85.71	SMESG000072807.1	[more]
SMESG000072805.1	4.656e-154	85.71	SMESG000072805.1	[more]
SMESG000072807.1	7.506e-154	85.71	SMESG000072807.1	[more]
SMESG000072805.1	7.506e-154	85.71	SMESG000072805.1	[more]
SMESG000072807.1	2.068e-150	84.87	SMESG000072807.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30031572 ID=SMED30031572|Name=Metalloendopeptidase|organism=Schmidtea mediterranea sexual|type=transcript|length=868bp
TGGAGACGAACTTCCTGTTTACGTTGCTGCAAGAGAATCGTATAAAAACC
GGAAGCATTCAGTATCAACACATTCATGGAAAAATTAATTCTCTTACTTT
TAGGATTTGTTGTGATTGACTATGCCAACGGCCAATGTGGATGTCCACGT
CAATCGGTGAAGCTGAGAACGAGAGGTCTCGACAATGTCAAGATGGGAGA
CATGCTTTTGGATTCCACAGATATACAGATCATCAATGGGTTCAAGAATC
ATTACGCAAACAGCAAGAAGTGGCCCAACAACATCGTCACGTATACATTT
GCAGGAAACTTCCCTCAAGACAAGATCCAAACTGTGCGACAATCTCTAGG
AGAATTACAGAAAGATTTACAAAACTGTGTCAAGTTTCAAGAAGGAAGAA
ACGGACATTACATCGAAGTCAACTCGAAACGTGAAGGATGTTATTCTATG
TTGGGAGTCACAGGAGGTCCTAGTCAGCCGTTGAATCTTGAAAACCCTGG
ATGTATGTATTCAAAAGGAACGATCAAACACGAGTTTATCCACGCCCTCG
GATTCATGCACACCCACATGAGAAAGGACAGAGACAACCACATCACTATC
AAATGGGATAGAATCTTGACCAGTCACTGCAGTCAGTTTGTCAAATGTGA
AGGTTGCGATTTGGACGGACCGTACGAAACCAACAGTGTAATGCATTATC
CAAGCTACGGATTCGCGTGCGTTCCCGGAGAAAATGTCGTCTTTAAACGA
GACGGAGGACTGATTGACTACAATCACGTAACATCAAGGAACGATTTGGA
CATGGTCCGAAAATTTTACGCTTGTTAAACTTTGAACAATAAATAATTGT
CTAAATCTTGAAAAAAAA

protein sequence of SMED30031572-orf-1

>SMED30031572-orf-1 ID=SMED30031572-orf-1|Name=SMED30031572-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=251bp
MEKLILLLLGFVVIDYANGQCGCPRQSVKLRTRGLDNVKMGDMLLDSTDI
QIINGFKNHYANSKKWPNNIVTYTFAGNFPQDKIQTVRQSLGELQKDLQN
CVKFQEGRNGHYIEVNSKREGCYSMLGVTGGPSQPLNLENPGCMYSKGTI
KHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPY
ETNSVMHYPSYGFACVPGENVVFKRDGGLIDYNHVTSRNDLDMVRKFYAC
*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000418	head
PLANA:0000429	neoblast

Vocabulary: **INTERPRO**
Term	Definition
IPR001506	Peptidase_M12A
IPR006026	Peptidase_Metallo
IPR024079	MetalloPept_cat_dom_sf

Vocabulary: **biological process**
Term	Definition
GO:0006508	proteolysis

Vocabulary: **molecular function**
Term	Definition
GO:0004222	metalloendopeptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding
GO:0008233	peptidase activity
GO:0016787	hydrolase activity
GO:0046872	metal ion binding

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR001506	Peptidase M12A	PRINTS	PR00480	ASTACIN	coord: 163..180 score: 41.76 coord: 144..162 score: 45.61
IPR001506	Peptidase M12A	PFAM	PF01400	Astacin	coord: 64..181 e-value: 1.3E-28 score: 99.9
IPR006026	Peptidase, metallopeptidase	SMART	SM00235	col_5	coord: 62..183 e-value: 1.8E-17 score: 74.1
IPR024079	Metallopeptidase, catalytic domain superfamily	GENE3D	G3DSA:3.40.390.10		coord: 20..183 e-value: 4.5E-34 score: 119.9
None	No IPR available	PANTHER	PTHR10127	DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING	coord: 38..181
None	No IPR available	PROSITE	PS51864	ASTACIN	coord: 54..183 score: 36.273
None	No IPR available	SIGNALP_EUK	SignalP-noTM	SignalP-noTM	coord: 1..19 score: 0.808
None	No IPR available	SUPERFAMILY	SSF55486	Metalloproteases ("zincins"), catalytic domain	coord: 62..181

Main menu

Metalloendopeptidase

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 20

Owlery

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