Cytochrome P450 2L1
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30031568 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 8
Homology
BLAST of Cytochrome P450 2L1 vs. Ensembl Human
Match: CYP1A1 (cytochrome P450 family 1 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:2595]) HSP 1 Score: 121.709 bits (304), Expect = 8.105e-29 Identity = 128/512 (25.00%), Postives = 218/512 (42.58%), Query Frame = 2
Query: 89 ILYKIKMLTDLFESSVFYLCLGIVAYIIYKWHFPKKHNLPPGPKAWPIIGSIPDPYSSP-LSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRP-LNSVDRLSVGNENIFFTRSLDAG--WTELRKQIMIMLRK---VAEPQKMTE------ISNNAYELFATHIREKKELVSDGGFYVEQLCYWVG-HNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNLAFFDITP-LNCLPHPGKNKILEYSKYLSDKVQKHIKERKSD---GNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDKLH--YLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKF-QSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKITWSSKNKTD 1561
+L+ I M F + CL + PK PPGP WP+IG + +P L+ R+ ++YG+++ + V +S QA V+ ++ GRP L + +S G F S D+G W R+ L+ ++P T +S A L +T +EL++ G + V N++ + + + ++ +++ VG+ D P L LP+P N + ++ +QK +KE G+ + I++C E Q ++ + L+D I N+ LD++ AG D SW++ L +P+VQ I++EL D S ++ D+ H Y+ A + E R S FT H D + + IPK + +N + ++D K W NP+EF P+RF+ DG + E + FG+G+R C+ E E F+F + Q + + K D
Sbjct: 1 MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHLALSRM----SQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQ-GDDFKGRPDLYTFTLISNGQSMSF---SPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLIST----LQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQ-------LSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEEL---DTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEV-FLFLAILLQRVEFSVPLGVKVD 489
BLAST of Cytochrome P450 2L1 vs. Ensembl Human
Match: CYP1A1 (cytochrome P450 family 1 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:2595]) HSP 1 Score: 121.709 bits (304), Expect = 8.105e-29 Identity = 128/512 (25.00%), Postives = 218/512 (42.58%), Query Frame = 2
Query: 89 ILYKIKMLTDLFESSVFYLCLGIVAYIIYKWHFPKKHNLPPGPKAWPIIGSIPDPYSSP-LSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRP-LNSVDRLSVGNENIFFTRSLDAG--WTELRKQIMIMLRK---VAEPQKMTE------ISNNAYELFATHIREKKELVSDGGFYVEQLCYWVG-HNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNLAFFDITP-LNCLPHPGKNKILEYSKYLSDKVQKHIKERKSD---GNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDKLH--YLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKF-QSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKITWSSKNKTD 1561
+L+ I M F + CL + PK PPGP WP+IG + +P L+ R+ ++YG+++ + V +S QA V+ ++ GRP L + +S G F S D+G W R+ L+ ++P T +S A L +T +EL++ G + V N++ + + + ++ +++ VG+ D P L LP+P N + ++ +QK +KE G+ + I++C E Q ++ + L+D I N+ LD++ AG D SW++ L +P+VQ I++EL D S ++ D+ H Y+ A + E R S FT H D + + IPK + +N + ++D K W NP+EF P+RF+ DG + E + FG+G+R C+ E E F+F + Q + + K D
Sbjct: 1 MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHLALSRM----SQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQ-GDDFKGRPDLYTFTLISNGQSMSF---SPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLIST----LQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQ-------LSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEEL---DTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEV-FLFLAILLQRVEFSVPLGVKVD 489
BLAST of Cytochrome P450 2L1 vs. Ensembl Human
Match: CYP1A1 (cytochrome P450 family 1 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:2595]) HSP 1 Score: 121.709 bits (304), Expect = 8.105e-29 Identity = 128/512 (25.00%), Postives = 218/512 (42.58%), Query Frame = 2
Query: 89 ILYKIKMLTDLFESSVFYLCLGIVAYIIYKWHFPKKHNLPPGPKAWPIIGSIPDPYSSP-LSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRP-LNSVDRLSVGNENIFFTRSLDAG--WTELRKQIMIMLRK---VAEPQKMTE------ISNNAYELFATHIREKKELVSDGGFYVEQLCYWVG-HNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNLAFFDITP-LNCLPHPGKNKILEYSKYLSDKVQKHIKERKSD---GNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDKLH--YLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKF-QSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKITWSSKNKTD 1561
+L+ I M F + CL + PK PPGP WP+IG + +P L+ R+ ++YG+++ + V +S QA V+ ++ GRP L + +S G F S D+G W R+ L+ ++P T +S A L +T +EL++ G + V N++ + + + ++ +++ VG+ D P L LP+P N + ++ +QK +KE G+ + I++C E Q ++ + L+D I N+ LD++ AG D SW++ L +P+VQ I++EL D S ++ D+ H Y+ A + E R S FT H D + + IPK + +N + ++D K W NP+EF P+RF+ DG + E + FG+G+R C+ E E F+F + Q + + K D
Sbjct: 1 MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHLALSRM----SQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQ-GDDFKGRPDLYTFTLISNGQSMSF---SPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLIST----LQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQ-------LSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEEL---DTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEV-FLFLAILLQRVEFSVPLGVKVD 489
BLAST of Cytochrome P450 2L1 vs. Ensembl Human
Match: CYP1B1 (cytochrome P450 family 1 subfamily B member 1 [Source:HGNC Symbol;Acc:HGNC:2597]) HSP 1 Score: 120.939 bits (302), Expect = 2.172e-28 Identity = 112/451 (24.83%), Postives = 189/451 (41.91%), Query Frame = 2
Query: 206 PPGPKAWPIIGSIPD-PYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTE------ISNNAYELFATHIREKKELVSDGGFY-VEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNLAFFDITP-LNCLPHPGKNKILEY-------SKYLSDKVQKHIKERKSDGNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKEL-QKNDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKF-QSPKEGFMPFGVGRRTCVAERYTVKESHFIF 1504
PPGP AWP+IG+ ++ LS+ RL +YG++ + V ++ + +QA V+ S A RP + R+ G ++ F W R+ M+R Q + + + A EL A +R +DG F L N++ V + D+P +++ +S + VG + D+ P L P+P + E+ S ++ DK +H + + P+ +D I + +K + +G L + DI+ A D W + L +P VQ ++ EL Q + + + L Y+ A + E MR S T H ++ V Y IPKDT++ +N + ++D W NP F+P RF++ DG + M F VG+R C+ E + K F+F
Sbjct: 51 PPGPFAWPLIGNAAAVGQAAHLSFARL----ARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGS-AFADRPAFASFRVVSGGRSMAFGH-YSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGS----ADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAA----PRDMMDAFI-LSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQ--PNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELS-KMQLFLF 483
BLAST of Cytochrome P450 2L1 vs. Ensembl Human
Match: CYP1B1 (cytochrome P450 family 1 subfamily B member 1 [Source:HGNC Symbol;Acc:HGNC:2597]) HSP 1 Score: 120.939 bits (302), Expect = 2.172e-28 Identity = 112/451 (24.83%), Postives = 189/451 (41.91%), Query Frame = 2
Query: 206 PPGPKAWPIIGSIPD-PYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTE------ISNNAYELFATHIREKKELVSDGGFY-VEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNLAFFDITP-LNCLPHPGKNKILEY-------SKYLSDKVQKHIKERKSDGNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKEL-QKNDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKF-QSPKEGFMPFGVGRRTCVAERYTVKESHFIF 1504
PPGP AWP+IG+ ++ LS+ RL +YG++ + V ++ + +QA V+ S A RP + R+ G ++ F W R+ M+R Q + + + A EL A +R +DG F L N++ V + D+P +++ +S + VG + D+ P L P+P + E+ S ++ DK +H + + P+ +D I + +K + +G L + DI+ A D W + L +P VQ ++ EL Q + + + L Y+ A + E MR S T H ++ V Y IPKDT++ +N + ++D W NP F+P RF++ DG + M F VG+R C+ E + K F+F
Sbjct: 51 PPGPFAWPLIGNAAAVGQAAHLSFARL----ARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGS-AFADRPAFASFRVVSGGRSMAFGH-YSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGS----ADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAA----PRDMMDAFI-LSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQ--PNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELS-KMQLFLF 483
BLAST of Cytochrome P450 2L1 vs. Ensembl Celegans
Match: cyp-13A10 (Putative cytochrome P450 CYP13A10 [Source:UniProtKB/Swiss-Prot;Acc:Q09653]) HSP 1 Score: 152.525 bits (384), Expect = 7.373e-40 Identity = 123/487 (25.26%), Postives = 215/487 (44.15%), Query Frame = 2
Query: 143 LCLGIVAYIIYKWHFPKKHNLPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTEISNNAYELFATHIREKKELVSDGG------FYVEQLCYWVGHNILVQVFWEDAVEFDNP----------NYQDTISVIGKLMAKVGNLAFFDITPLNCLPHPGKNKILEYSKYLSDKVQKHIKERKSDGNYKVN---PKYFIDYCIEIQDNQKE----------QKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYW-KNPNEFNPDRFI--NADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFT 1507
L +G ++Y ++ W + ++ +P GP +P++GS P S I DW + YG I + + + + VSD + Q FV+ Y N GR LN + +E + W LR + + + ++A EL +R +E S+G FY E +G + Q D+ F NP + + I +IG + + + F + P G + +K + VQ I +R++D + P+ FID +E + + E + YG + T + L AG D + S+T LLATHP+VQ +++E+++ IE SF++ + KL Y++ ++ E +R++ L + + R M K+G ++ T++ ++ + H D+K W + EF P+R++ N D FQ K G++ FG+G R CV R E +
Sbjct: 11 LFIGFISYYLWIWTYWRRRGIP-GPLGYPLVGSFPKTLKSEYPQYLQIRDWTKLYGPIYGYTEGTIKTLIVSDIDIVRQIFVEQYDN-FYGRKLNPIQGDPEKDERTNLFSAQGFRWKRLRAISSPTFSNNSLRKINVTVEDSAMEL----LRHIEEQTSEGQQIDMLQFYQEFTMDTIGRIAMGQT---DSQMFKNPLLKFVRAIFGDNRKHIPLIGGVFPTLAQVFRFFMLKF---PLLGAANFIHVNKTVVTAVQNRIDQRENDRKNGIEIGEPQDFIDLFLEARADDVEHFQENNGDFSKTSSYGNRQLTTQEIVGQ-CLVFLIAGFDTTALSLSYTTFLLATHPEVQKKLQEEIERECIEPSISFDH--LSKLKYMDCIIKETLRLYPLGTMANSRRCMRATKLGNVEVEVGTMVQVDTWSLHTDTKIWGDDAKEFKPERWLDPNCDQVFQ--KGGYISFGLGPRQCVGMRLAYMEEKMLLA 480
BLAST of Cytochrome P450 2L1 vs. Ensembl Celegans
Match: cyp-13A12 (CYtochrome P450 family [Source:UniProtKB/TrEMBL;Acc:O17807]) HSP 1 Score: 131.724 bits (330), Expect = 1.368e-32 Identity = 122/485 (25.15%), Postives = 218/485 (44.95%), Query Frame = 2
Query: 131 SVFYLCLGIVAYIIYKWHFPKKHNLPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTEISNNAYELFATHIREKKELVSDGG-------FYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIG---KLMAKVGNLAFFDITP-----LNCLPHPGKNKILEYSKYLSDKVQKHIKERKSDGNYKVNP---KYFIDYC-------IEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYW-KNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFT 1507
++ +G++++ ++ W + K+ + GP +PI+GS + SS +++W ++YG++ + + +SD L + FVK Y N GR LN + ++ + S W LR + + T + A EL HI + +DGG FY E +G + Q D+ F NP +V G K + G+LA + I P + LP+ KN + ++ S+ V++ +K R +D ++P + FID +E+++N+ K LT I AG D + S++ LLATHP+VQ +++E+ + + +F+ + KL Y+ V+ E +R++ L + + M K+G Y+I + T I + + H D W ++ EF P+R+ + D F K G++PFG+G R C+ R E + +
Sbjct: 7 AILTSIIGVLSFYLWTWSYWKRRGIA-GPSGYPILGSALEMLSSENPPYLQLKEWTKQYGKVYGITEGLSRTLVISDPDLVQEVFVKQYDN-FFGRKLNPIQGDPNKDKRVNLFSSQGHRWKRLRTISSPTFSNNSLRKLKTTVEECAVELLR-HIEQH----TDGGQPIDLLDFYQEFTLDVIGRIAMGQT---DSQMFKNPLLPYVRAVFGEPRKGLFLSGSLAPW-IGPILRMVMFSLPNIVKNPAVHVIRHTSNAVEQRVKLRMADEKAGIDPGEPQDFIDLFLDAKSDDVELENNEDFTKAGVKVTRQLTTEEIVGQCFVFLIAGFDTTALSLSYSSFLLATHPKVQKKLQEEIDRECADPEVTFD--QLSKLKYMECVIKETLRMYPLGALANSRCCMRATKIGNYEIDEGTNILCDTWTLHSDKSIWGEDAEEFKPERWESGDEHFYQ-KGGYIPFGLGPRQCIGMRLAYMEEKLLLS 477
BLAST of Cytochrome P450 2L1 vs. Ensembl Celegans
Match: cyp-13A11 (CYtochrome P450 family [Source:UniProtKB/TrEMBL;Acc:O17806]) HSP 1 Score: 120.168 bits (300), Expect = 1.081e-28 Identity = 110/474 (23.21%), Postives = 204/474 (43.04%), Query Frame = 2
Query: 164 YIIYKWHFPKKHNLPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTEISNNAYELFATHIREKKELVSDGGFYVEQLCYW-------VGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKV--GNLAFFDITPL---------NCLPHPGKNKILEYSKYLSDKVQKHIKERKSDGNYKVNPKYFIDYCIEIQ--DNQKEQKEKYGQLPI-----LTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYW-KNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFT 1507
Y + W + ++ +P GP+ +P +GS D ++ W +YG++ + + + +SD L ++ FVK Y N GR LN + + + + W LR + + ++A EL HI + + GG ++ L Y+ +G + Q D++ F NP V GK + + F I P+ N +P + + + + ++++ + E K+ G P+ FID ++ + D + E E + + + LT + AG D + S++ LLATHP+ Q +++E+ + + +F+ + KL Y+ V+ E +R++ L + + R M K+G Y+I K I + + HYD W ++ EF P+R+ + D F K G++PFG+G R C+ R E + +
Sbjct: 17 YYFWTWTYWRRCGIP-GPQGYPFLGSALDMMDHENPPFLQLKKWTSQYGKVYGITEGLLRTLVISDTNLIHEVFVKQYDN-FYGRNLNPIQGDPNREKRVTLFSAQGHRWKRLRTIANPTFSSNNLRKIQVTVEDSALELL-RHIEQH----TAGGKAIDVLEYFQEFTMDVIGRIAMGQ---PDSLMFKNPLLPCARDVFGKPRTALFLSGILFPWIGPMIRKVVFYFTNVFNNPAAQIMYQTANAVEQRIKQRMAEEKA-GIDPGEPQDFIDLFLDAKSDDMELENNEDFTKAGVKVTRQLTKDEVVGQCFVFLIAGFDTTALSLSYSSFLLATHPKAQKKLQEEIDRECADPEVTFD--QLSKLKYMECVIKETLRMYPLGALANSRRCMRSTKIGNYEIEKGVDILCDTWTLHYDKSIWGEDAEEFKPERWESGDEHFYQ-KGGYIPFGLGPRQCIGMRLAYMEEKLLLS 476
BLAST of Cytochrome P450 2L1 vs. Ensembl Celegans
Match: cyp-13A1 (Putative cytochrome P450 CYP13A1 [Source:UniProtKB/Swiss-Prot;Acc:Q27520]) HSP 1 Score: 119.783 bits (299), Expect = 1.374e-28 Identity = 113/496 (22.78%), Postives = 212/496 (42.74%), Query Frame = 2
Query: 128 SSVFYLCLGIVAYIIYKWHFPKKHNLPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLNSV--DRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTEISNNAYELFATHIREKKELVSDGGFYVEQLCYW-------VGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNLA------------FFDITPLNCLPHPGKNKILEYSKYLSDKVQKHIKERKSDGNYKVN---PKYFIDYCIEIQDNQKE----------QKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNE-FNPDRF--INADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIF 1504
S++F + + +Y I++W F ++ + GP +P++G + + + +W +K+G+I F + + + +SD +L ++ FV Y N GR N + D N+F + W LR + + + ++A EL HI ++ S GG ++ L ++ +G + Q D+ F NP + ++ KL GN A +I L + + ++ D + IK+R+ D + P FID ++ + E + Y + T+ + ++ AG D + S+ LLATHP++Q +++E+ + + N E + KL Y+ V E +R++ L +F + R M + K+G + T+I ++ + H D W + E F P+R+ N+D +Q K G++PFG+G R C+ R E +
Sbjct: 10 SAIF---VAVFSYYIWQWTFWRRRGVV-GPMGFPVLGVFLNSLDNNFPFPLQCREWTKKFGKIYGFTEGTLKTLVISDPELVHEVFVTQYDN-FYGRKRNPIQGDSEKEKRTNLFAAQGFR--WKRLRAISSPTFSNSSLRKLYQTVEDSALELLR-HIEKQ----SAGGKQIDMLKFYQEFTLDVIGRIAMGQT---DSQMFKNP----IMPIVSKLFQ--GNFAKLFLIGGIFPTFLVEIIRQILLKNLKVGSFRKINEITLDAIHNRIKQREEDQKNGIEIGEPADFIDLFLDAKAEDVEHFGENNGDFSKSTTYTNRQLTTEEIVGQCTV-FLIAGFDTTALSLSYATYLLATHPEIQKKLQEEVNR-ECPNPE-VTIDQLSKLKYMECVFKEALRLYPLGAFANSRRCMRNTKLGNMKVEVGTMIQVDTWTLHTDPNIWGDDAEDFKPERWQTPNSDQIYQ--KSGYIPFGLGPRQCIGMRLAYMEEKILL 479
BLAST of Cytochrome P450 2L1 vs. Ensembl Celegans
Match: cyp-13A8 (Putative cytochrome P450 CYP13A8 [Source:UniProtKB/Swiss-Prot;Acc:Q27516]) HSP 1 Score: 115.931 bits (289), Expect = 2.402e-27 Identity = 113/486 (23.25%), Postives = 195/486 (40.12%), Query Frame = 2
Query: 143 LCLGIVAYIIYKWHFPKKHNLPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTEISNNAYELFATHIREKKE---LVSDGGFYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQD---------------------TISVIGKLMAKVGNLAFFDITPLNCLPHPGKNKILEYSKYLSDKVQKHIKERKSDGNYKVNPKYFIDYCIEIQDNQKEQKEKYGQL------------PILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNP-NEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKE 1489
+ + IV Y + W F K+ LP GP PI G ++ W ++YG+I F + + +SD L + VK Y N GR N V +++I + W LR + + +T + ++ EL +RE+ E V+ FY E + + Q D+ F NP +D +S + L KVG G + K ++D V I +R++D + V P DY I++ N + + E +G+ LT I + AG D I S+ LA +P++Q ++ E+ K + N E + + KL Y++ V+ E +R+ +SF + R M + +GE + + ++ + H+D W N EF P+R+ + +P++ ++ FG G R C+ R+ + E
Sbjct: 6 ILISIVTYYFWHWTFWKRRGLP-GPWGVPIFGKAGAMLEDSFPPGYTLQKWTKEYGKIYGFTEGMQKVMVISDPDLVQEILVKQYDN-FYGRKHNPVQGDPDKDKDIHIVGAQGFRWKRLRTITAPAFSNGSIKKVLTTMEDSTQELMK-KLREESENGKAVNMHLFYQEYTFDVISRVAMGQ---PDSQMFKNPLLKDVKGFFEHNRWQIWMFSGGFPFAVSFLKWLFIKVGKF--------------GAGPFIVVQKSVTDAVMSRIAQREADKKHGVEPGEAADY-IDMFLNARAEVEHFGESNDEFHKSSSYNNRQLTTQEIISQCFVFLVAGFDTTAISLSYVTYFLALNPKIQSKLQDEVDK-ECPNDE-ITFDQLSKLKYMDNVIKESLRLFPFASFANSRRCMRNTVIGEQIVEAGVDVMIDTWTLHHDKNVWGNDVEEFKPERWDSP----LTPQQAYLSFGAGPRVCLGMRFALLE 464
BLAST of Cytochrome P450 2L1 vs. Ensembl Fly
Match: Cyp18a1 (gene:FBgn0010383 transcript:FBtr0074610) HSP 1 Score: 113.235 bits (282), Expect = 3.595e-26 Identity = 113/453 (24.94%), Postives = 189/453 (41.72%), Query Frame = 2
Query: 203 LPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTEISNNAYELFATHIREKKELV-----SDGG-FYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNLAFFDITP-LNCLPH--PGKNKIL----EYSKYLSDKVQKHIKERKSDGNYKVNPKYFID-YCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHP----QVQDNIRKELQKNDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFT 1507
LPPGP P+IG + + + R +E K+ YG + + V +SDYK+ + F ++ E GRP + G I T L W + R+ + LR+ MT + N ++ + E E + SDG + + N++ + D+P ++ +I + M G + D P + C P KNKI E ++ D + H +R D N N + +D Y EI+ + E + + + + +D++ AGM+ W + +P +VQD + + + ++ + +E Y L + + E MR S+ + H DV++ Y IP + + I H D W+ P EF P RFI+ +GK + P E F+PFGVGRR C+ + E F
Sbjct: 53 LPPGPWGLPVIGYLL--FMGSEKHTRFMELAKQ-YGSLFSTRLGSQLTVVMSDYKMIRECFRRE---EFTGRPDTPFMQTLNGYGIINSTGKL---WKDQRRFLHDKLRQFG----MTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDPKFRRFNFLIEEGMRLFGEIHTVDYIPTMQCFPSISTAKNKIAQNRAEMQRFYQDVIDDH--KRSFDPN---NIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQY-----LPITESTILESMRRSSIVPLATTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKP-EYFIPFGVGRRMCLGDVLARMELFLFFA 481
BLAST of Cytochrome P450 2L1 vs. Ensembl Fly
Match: Cyp18a1 (gene:FBgn0010383 transcript:FBtr0074609) HSP 1 Score: 113.235 bits (282), Expect = 3.595e-26 Identity = 113/453 (24.94%), Postives = 189/453 (41.72%), Query Frame = 2
Query: 203 LPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTEISNNAYELFATHIREKKELV-----SDGG-FYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNLAFFDITP-LNCLPH--PGKNKIL----EYSKYLSDKVQKHIKERKSDGNYKVNPKYFID-YCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHP----QVQDNIRKELQKNDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFT 1507
LPPGP P+IG + + + R +E K+ YG + + V +SDYK+ + F ++ E GRP + G I T L W + R+ + LR+ MT + N ++ + E E + SDG + + N++ + D+P ++ +I + M G + D P + C P KNKI E ++ D + H +R D N N + +D Y EI+ + E + + + + +D++ AGM+ W + +P +VQD + + + ++ + +E Y L + + E MR S+ + H DV++ Y IP + + I H D W+ P EF P RFI+ +GK + P E F+PFGVGRR C+ + E F
Sbjct: 53 LPPGPWGLPVIGYLL--FMGSEKHTRFMELAKQ-YGSLFSTRLGSQLTVVMSDYKMIRECFRRE---EFTGRPDTPFMQTLNGYGIINSTGKL---WKDQRRFLHDKLRQFG----MTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDPKFRRFNFLIEEGMRLFGEIHTVDYIPTMQCFPSISTAKNKIAQNRAEMQRFYQDVIDDH--KRSFDPN---NIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQY-----LPITESTILESMRRSSIVPLATTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKP-EYFIPFGVGRRMCLGDVLARMELFLFFA 481
BLAST of Cytochrome P450 2L1 vs. Ensembl Fly
Match: Cyp303a1 (gene:FBgn0001992 transcript:FBtr0343812) HSP 1 Score: 110.923 bits (276), Expect = 1.339e-25 Identity = 117/494 (23.68%), Postives = 210/494 (42.51%), Query Frame = 2
Query: 119 LFESSVFYLCLGIVAYIIYKWHFPKKHNLPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNE----------LAGRPLNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQK-MTEISNNAYELFATHIREKKELVSDGG----FYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNL-AFFDITPLNCLPHP---GKNKILEYSKYLSDKVQKHIK-ERKSDGNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKN-DIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKIT 1537
+F + ++ C ++A + PK+ PPGP +PI+GS L +L I +F + +N K+G V Y+N+ + GRP RL N + + W E R+ I+ L+ + M +I +N +++K ++ GG + L N L + E +P + +L + + A F PL P G N +E + L + K I+ R + NY P+ +D + QD ++K + +D + + LD++ AG + + L P++Q+ +E+++ +E + ++ + KL Y A+ E +R+ L +F HRA+ D ++ Y+IPKDT++ G + + +P FNPDR++ DG + P E F PFG GR C+ + +++ F+FT + Q+FK+
Sbjct: 1 MFYTVIWIFCATLLAILFGGVRKPKR--FPPGPAWYPIVGS-------ALQVSQLRCRLGMFCKVIDVFARQYVNPYGFYGLKIGKDKVVIAYTNDAISEMMTNEDIDGRPDGIFYRLRTFNSRLGVLLTDGEMWVEQRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDK--VLKSGGKQTRIEMHDLTSVYVLNTLWCMLSGRRYEPGSPEITQLLETFFELFKNIDMVGALFSHFPLLRFIAPNFSGYNGFVESHRSLYTFMSKEIELHRLTYKNYD-EPRDLMDSYLRAQDEGNDEKGMF------SDQSLLAICLDMFLAGSETTNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWS-RDRTKLPYCEAITLEAVRMFMLHTFGIPHRAVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYL-FDGHLKLP-EAFNPFGFGRHRCMGDLLG-RQNLFMFTTTVLQNFKMV 472
BLAST of Cytochrome P450 2L1 vs. Ensembl Fly
Match: Cyp303a1 (gene:FBgn0001992 transcript:FBtr0080828) HSP 1 Score: 110.923 bits (276), Expect = 1.339e-25 Identity = 117/494 (23.68%), Postives = 210/494 (42.51%), Query Frame = 2
Query: 119 LFESSVFYLCLGIVAYIIYKWHFPKKHNLPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNE----------LAGRPLNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQK-MTEISNNAYELFATHIREKKELVSDGG----FYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNL-AFFDITPLNCLPHP---GKNKILEYSKYLSDKVQKHIK-ERKSDGNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKN-DIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKIT 1537
+F + ++ C ++A + PK+ PPGP +PI+GS L +L I +F + +N K+G V Y+N+ + GRP RL N + + W E R+ I+ L+ + M +I +N +++K ++ GG + L N L + E +P + +L + + A F PL P G N +E + L + K I+ R + NY P+ +D + QD ++K + +D + + LD++ AG + + L P++Q+ +E+++ +E + ++ + KL Y A+ E +R+ L +F HRA+ D ++ Y+IPKDT++ G + + +P FNPDR++ DG + P E F PFG GR C+ + +++ F+FT + Q+FK+
Sbjct: 1 MFYTVIWIFCATLLAILFGGVRKPKR--FPPGPAWYPIVGS-------ALQVSQLRCRLGMFCKVIDVFARQYVNPYGFYGLKIGKDKVVIAYTNDAISEMMTNEDIDGRPDGIFYRLRTFNSRLGVLLTDGEMWVEQRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDK--VLKSGGKQTRIEMHDLTSVYVLNTLWCMLSGRRYEPGSPEITQLLETFFELFKNIDMVGALFSHFPLLRFIAPNFSGYNGFVESHRSLYTFMSKEIELHRLTYKNYD-EPRDLMDSYLRAQDEGNDEKGMF------SDQSLLAICLDMFLAGSETTNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWS-RDRTKLPYCEAITLEAVRMFMLHTFGIPHRAVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYL-FDGHLKLP-EAFNPFGFGRHRCMGDLLG-RQNLFMFTTTVLQNFKMV 472
BLAST of Cytochrome P450 2L1 vs. Ensembl Fly
Match: Cyp304a1 (gene:FBgn0038095 transcript:FBtr0082691) HSP 1 Score: 104.375 bits (259), Expect = 2.173e-23 Identity = 53/189 (28.04%), Postives = 93/189 (49.21%), Query Frame = 2
Query: 1025 LDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQK----NDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKITWSSKNKTDKVEEDL 1579
+D F A G+ S + L +P V ++ E+ + + N+E L + A + E +RI +L H+A+ D ++ Y IPKDTI+ ++Y H D++ W +P +F P+RF++ADGK + +PFG G+R C E + + F+ T +CQ F ++ + ++L
Sbjct: 310 VDFSFPAFTAIGVQLSLLVQYLMLYPAVLRRVQNEIDEVVGCGRLPNLED-----RKNLPFTEATIREGLRIETLVPSDVPHKALEDTELLGYRIPKDTIVVPSLYAFHSDARIWSDPEQFRPERFLDADGKLCLKLDVSLPFGAGKRLCAGETFA-RNMLFLVTATMCQHFDFVLGPNDRLPDLSQNL 492
BLAST of Cytochrome P450 2L1 vs. Ensembl Zebrafish
Match: cyp2aa4 (cytochrome P450, family 2, subfamily AA, polypeptide 4 [Source:ZFIN;Acc:ZDB-GENE-040625-72]) HSP 1 Score: 145.591 bits (366), Expect = 2.965e-37 Identity = 114/470 (24.26%), Postives = 210/470 (44.68%), Query Frame = 2
Query: 194 KHNLPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRP-LNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTE--ISNNAYELFATHIREKKELVSDGGFYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNL--AFFDITP-LNCLPHPG---KNKILEYSKYLSDKVQKHIKERKSDGNYKVNPKYFID-YCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMM------DKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKITWSSKNK 1555
K PPGP P +G++P P+ + RL+ +YGE+ + ++ ++ +A V++ AGRP L +D S G I T + W + R+ + LR +K E + + LFA ++++ E V+ + NI + + + ++DN + ++ + M G+ F++ P + P P K E ++ D+V++H K V+P+ FID Y +EI+ + + + + ++ ++D++FAG D+ W + L +P VQ+ +E+ V+ Y + D+L Y +A V+E+ R F FH + K+ +DIP+ T+I N+ ++WK+P+ FNP+ F++ +G F P E ++PF +G R C+ E V+ F+F + Q +W K
Sbjct: 36 KSRFPPGPTPLPFVGNLPHLLRDPMGFNRLMA----QYGEMSTMYLGKKPAIVLNTIQVAKEALVQE---AFAGRPCLPVIDWTSNGCGIIMAT--FNNSWKQQRRFALHTLRNFGLGKKSIESRVLEESQYLFAELLKDEGEPVNPHHALQNAVS-----NIFCSIMFGERFDYDNKRLGYLLKILNENMMLTGSAIGQIFNLAPFIKHFPGPHQKIKKNSNELYSFIEDEVEEHRKTLDP-----VSPRDFIDAYLLEIEKQKSNKDSTFQEENLIGS------AIDLFFAGTDSTATSIRWGLLFLIQNPDVQERCHEEI-------VQVLGYDRLPCMDDCDRLPYTHATVHEIQRFAKTVPFGVFHETIWPTKLHGFDIPQGTMIMTNLAAIFSSKEHWKHPDTFNPENFLDENGHFSKP-ESYIPFSLGLRACIGESL-VRTELFLFATVLLQRIHFSWPPDAK 471
BLAST of Cytochrome P450 2L1 vs. Ensembl Zebrafish
Match: cyp2aa11 (cytochrome P450, family 2, subfamily AA, polypeptide 11 [Source:ZFIN;Acc:ZDB-GENE-110114-3]) HSP 1 Score: 145.206 bits (365), Expect = 4.452e-37 Identity = 126/518 (24.32%), Postives = 236/518 (45.56%), Query Frame = 2
Query: 101 IKMLTDLFESSVFYLCLGIVAYIIYKWHFPKKHNLPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLNSVDRLSVGNENIFFTRSLDA-GWTELRKQIMIMLRKVAEPQKMTE--ISNNAYELFATHIREKKELVSDGGFYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNLA--FFDITPL-NCLPHPGKNKIL----EYSKYLSDKVQKHIKERKSDGNYKVNPKYFID-YCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKEL-QKNDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKITWSSKNKTDKVEEDLENTFFRHTAPFYV 1618
+ + LF ++F +C IYK +P PGP P +G+IP +P+ + R + +YGE+ + ++ +L +AFV++ S+ +GRP V L+ N+ ++D W + R+ + LR +K E ++ + L + +R V F + + NI+ + + D ++DN ++ + +I + + G+ A ++ P+ LP P KI E+ ++ + V+ H + D +P+ FID Y +E++ + Q + + D + ++ D++FAG D W + L +P VQ+ E+ Q + S + + D+L Y A V+E+ R +++ H+ +K+ YDIP+ T I +N+ G + ++WK+P+ FNP+ F++ G F P E F+PF +G R C+ E K F+F + Q + +W + K + L + R PF +
Sbjct: 15 LSLFLGLFCLALFEIC----RIRIYKGRYP------PGPTPLPFVGTIPHFLKNPMGFIRSLS----QYGEMTTVYLGRKPAIILNALQLMKEAFVQNGSS-FSGRP--PVPVLTWVNQGYGIIMAMDGHSWRQQRRFALHTLRNFGLGKKSVEERVTEESGYLISELLR-----VEGKPFNPQHAIHNAAANIICSIVFGDRFDYDNKSFTYLLEIIKENLDLAGSFAGQMVNLVPIIKNLPGP-HQKIYQNGEEFKSFIRESVKAHRETLDPD-----SPRDFIDAYLLEMEKQKSTQDSTFHE-----DNMVMSVG-DLFFAGTDTTATTIRWGLLYLTQNPDVQERCHDEIVQVLGFDCFPSMDDR--DQLPYTLATVHEIQRCANVAPSGVPHQTTKPIKLRGYDIPQGTQILINLMGILANKEHWKHPDTFNPENFLDDKGHFFKP-EAFLPFSLGPRACLGETL-AKTELFLFVTSLLQRIRFSWPTGEKWPDMNRIL--SVIRSPEPFNI 492
BLAST of Cytochrome P450 2L1 vs. Ensembl Zebrafish
Match: cyp2aa8 (cytochrome P450, family 2, subfamily AA, polypeptide 8 [Source:ZFIN;Acc:ZDB-GENE-041010-183]) HSP 1 Score: 142.124 bits (357), Expect = 5.082e-36 Identity = 121/491 (24.64%), Postives = 220/491 (44.81%), Query Frame = 2
Query: 119 LFESSVFYLCLGIVAYIIYKWHFPKKHNLPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRP-LNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTE--ISNNAYELFATHIREKKELVSDGGFYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNLA--FFDITPL-NCLPHPGKNKILEYSKYLSDKVQKHIKERKSDGNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMM------DKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKITWSSKNK 1555
LF +F + I YK FP PGP P +G++P +P+ + R + +YGE+ + ++ +L + ++D AG+P L +D +S G + T + W + R+ + LR +K E + + L A +++K + V+ + Q + N++ + + D ++D+ ++ + ++GK M G+ A F+ P+ P P + KI + + LS Q +KE K + +P+ +ID + + QK K+ D + + D++ AG D+ F W + L +P VQ+ KE+ V+ Y + D+L Y A V+E+ R +L+ F H + K+ YD+P+ T I +N+ + + WK+P+ FNP+ F++ G+F S E F+PF +G R C+ E E F+F + Q + + K
Sbjct: 17 LFLGLIFLVLFEIFRINSYKGRFP------PGPTPLPFVGNLPHSLKNPMEFIRSLS----QYGEMTTIYLGRKPTIMLNTVQLAKEVLIQD---AFAGKPSLPVLDWVSNGLGIVMVT--FNHSWRQQRRFALHTLRNFGLGRKSVESRVLEESQYLIAELLKKKGKSVNP--HHALQNAF---SNVICSIVFGDRFDYDDKRFEHFLEILGKSMILTGSTAGQIFNFAPIIKHFPGPHQ-KIKKNADELSGFFQHEVKEHKKTLD-PGSPRDYIDAYLLEMEKQKSNKDS-----TFHDENLIGSTTDLFVAGSDSTATTFRWGLLFLIQNPDVQERCHKEI-------VQVLGYDRLPSMEDRDRLPYTLATVHEIQRCANLAPFGLIHETIQPTKLQGYDLPRGTTIIVNLTAIFSNKENWKHPDTFNPENFLDESGQF-SKHESFIPFSLGVRVCLGETLARTEL-FLFITALLQRIRFSLPPDAK 471
BLAST of Cytochrome P450 2L1 vs. Ensembl Zebrafish
Match: cyp2p8 (cytochrome P450, family 2, subfamily P, polypeptide 8 [Source:ZFIN;Acc:ZDB-GENE-061030-1]) HSP 1 Score: 139.813 bits (351), Expect = 2.649e-35 Identity = 113/478 (23.64%), Postives = 221/478 (46.23%), Query Frame = 2
Query: 125 ESSVFYLCLGIVAYIIYKWHFPKKHNLPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTEISNNAYELFATHIREKKELVSDGGFYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNLA--FFDITP--LNCLPHPGKNKILEYSKYLSDKVQKHIKERKSDGNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLPILTDWFISNL---SLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKIT 1537
+S + +LC+ ++ K PK N PPGP + PIIG + +S + + + E+YG I F+ G V ++ Y L + ++K N LA RP+ + VG++ + + W R+ + LR +K E S N F ++ F L N++ + + + ++ + ++Q + I + + G++ +++ P + LP P K I + K ++D V++ + E + D + NP+ +ID + + K+ + + NL SLD++ AG + W + + +P++Q +++E+ + + D + Y NAV++E+ R+ +++ D ++G Y IPK T++ N+ +D W+ P+ FNP F++A+GKF+ ++ F+PF +G+R C+ E+ E F+F + Q F +
Sbjct: 13 KSILIFLCVFLLLGDYIKNKAPK--NFPPGPWSLPIIGDLHHIDNSKIHLQ--FTKFAERYGNIFSFRLFGPRIVVLNGYNLVKEVYIKQGDN-LADRPVLPLFYEIVGDKGLILSSGYK--WKHQRRFALSTLRNFGLGKKSLEPSINVECGFLNEAISNEQ---GRPFDPRLLLNNAVSNVICVLVFGNRFDYSDHHFQTLLKNISEAVYLEGSICNQLYNMFPWLMERLPGPHKTIITLWRK-VTDFVREKVNEHRVDYD-PSNPRDYIDCFLTEMEKLKDDTA--------AGFDVENLCICSLDLFVAGTETTSTTLYWGLLYMIKYPEIQAKVQEEIDAV-VGGSRQPSVSDRDNMPYTNAVIHEIQRMGNIAPINLARSTSEDTQIGNYSIPKGTMVTSNLTSVLFDESEWETPHSFNPGHFLDAEGKFRR-RDAFLPFSLGKRVCLGEQLARMEL-FLFFSSLLQRFTFS 467
BLAST of Cytochrome P450 2L1 vs. Ensembl Zebrafish
Match: cyp2aa8 (cytochrome P450, family 2, subfamily AA, polypeptide 8 [Source:ZFIN;Acc:ZDB-GENE-041010-183]) HSP 1 Score: 139.428 bits (350), Expect = 4.502e-35 Identity = 115/466 (24.68%), Postives = 212/466 (45.49%), Query Frame = 2
Query: 194 KHNLPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRP-LNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTE--ISNNAYELFATHIREKKELVSDGGFYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNLA--FFDITPL-NCLPHPGKNKILEYSKYLSDKVQKHIKERKSDGNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMM------DKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKITWSSKNK 1555
K PPGP P +G++P +P+ + R + +YGE+ + ++ +L + ++D AG+P L +D +S G + T + W + R+ + LR +K E + + L A +++K + V+ + Q + N++ + + D ++D+ ++ + ++GK M G+ A F+ P+ P P + KI + + LS Q +KE K + +P+ +ID + + QK K+ D + + D++ AG D+ F W + L +P VQ+ KE+ V+ Y + D+L Y A V+E+ R +L+ F H + K+ YD+P+ T I +N+ + + WK+P+ FNP+ F++ G+F S E F+PF +G R C+ E E F+F + Q + + K
Sbjct: 36 KSRFPPGPSPLPFVGNLPVFLKNPMEFIRSLS----QYGEMTTIYLGRKPTIMLNTVQLAKEVLIQD---AFAGKPSLPVLDWVSNGLGIVMVT--FNHSWRQQRRFALHTLRNFGLGRKSVESRVLEESQYLIAELLKKKGKSVNP--HHALQNAF---SNVICSIVFGDRFDYDDKRFEHFLEILGKSMILTGSTAGQIFNFAPIIKHFPGPHQ-KIKKNADELSGFFQHEVKEHKKTLD-PGSPRDYIDAYLLEMEKQKSNKDS-----TFHDENLIGSTTDLFVAGSDSTATTFRWGLLFLIQNPDVQERCHKEI-------VQVLGYDRLPSMEDRDRLPYTLATVHEIQRCANLAPFGLIHETIQPTKLQGYDLPRGTTIIVNLTAIFSNKENWKHPDTFNPENFLDESGQF-SKHESFIPFSLGVRVCLGETLARTEL-FLFITALLQRIRFSLPPDAK 471
BLAST of Cytochrome P450 2L1 vs. Ensembl Xenopus
Match: cyp17a1 (cytochrome P450 family 17 subfamily A member 1 [Source:NCBI gene;Acc:100145650]) HSP 1 Score: 134.42 bits (337), Expect = 3.047e-33 Identity = 122/471 (25.90%), Postives = 215/471 (45.65%), Query Frame = 2
Query: 155 IVAYIIYKWHFPKKHNLPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLN-SVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTE--ISNNAYELFATHIREKKELVSDGGFYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNLAFFDITP-LNCLPHPGKNKILEYSKYLSDKV-QKHIKERKSD-GNYKVNPKYFIDYCI--EIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDK--LHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGK-FQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKI 1534
++ ++ + W P+ P P IGS+ +S L+ L +EKYG + FK MG +++ + ++ + + GRP + D L+ ++I F W RK + L E E IS A L T I + + +L V N++ + + + +P +++ ++ ++ V + DI P L P+ +IL+ S + DK+ QK +KE K +VN +++N ++ G LTD + DI+ AG++ WT+ L +P+VQ I++EL D++ + + D+ L YL+A ++EV+RI ++ H A+ + +GEY IP+D + +N++ H+D W+NP EF PDRF++ +G +P + ++PFG G R C+ E E F+F I Q F +
Sbjct: 11 MLQFLRFMWGKPRGAKYPNSLPCLPFIGSLLH-LASHLAPHILFNKLQEKYGSLYSFK-MGSHYIVIVNHHEHAKEVLLKKGKTFGGRPRAVTTDLLTRNAKDIAFA-DYSPTWKFHRKLVHAALSMFGEGTVAIEKIISREAASLCQTLITFQGSPLD----MAPELTRAVT-NVVCALCFNARYKRCDPEFEEMLAYSKGIVDTVAKDSLVDIFPWLQIFPNKDL-EILKRSVAIRDKLLQKKLKEHKEAFCGEEVNDLLDALLKAKLSMENNNSNISQEVG----LTDDHLLMTVGDIFGAGVETTTTVLKWTVAYLLHYPKVQAKIQEEL---DVKVGFGRHPVLSDRRILPYLDATISEVLRIRPVAPLLIPHVALHESSIGEYTIPQDARVVINLWSLHHDPNEWENPEEFIPDRFLDENGNHLYTPSQSYLPFGAGIRVCLGEALAKMEI-FLFLSWILQRFTL 464
BLAST of Cytochrome P450 2L1 vs. Ensembl Xenopus
Match: cyp17a1 (cytochrome P450 family 17 subfamily A member 1 [Source:NCBI gene;Acc:100145650]) HSP 1 Score: 132.494 bits (332), Expect = 1.815e-32 Identity = 125/484 (25.83%), Postives = 219/484 (45.25%), Query Frame = 2
Query: 122 FESSVFYLCLGIVAYIIYKWHF--PKKHNLPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLN-SVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTE--ISNNAYELFATHIREKKELVSDGGFYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNLAFFDITP-LNCLPHPGKNKILEYSKYLSDKV-QKHIKERKSD-GNYKVNPKYFIDYCI--EIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDK--LHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGK-FQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKI 1534
+ ++ L G+ I+K+ P+ P P IGS+ +S L+ L +EKYG + FK MG +++ + ++ + + GRP + D L+ ++I F W RK + L E E IS A L T I + + +L V N++ + + + +P +++ ++ ++ V + DI P L P+ +IL+ S + DK+ QK +KE K +VN +++N ++ G LTD + DI+ AG++ WT+ L +P+VQ I++EL D++ + + D+ L YL+A ++EV+RI ++ H A+ + +GEY IP+D + +N++ H+D W+NP EF PDRF++ +G +P + ++PFG G R C+ E K F+F I Q F +
Sbjct: 4 YVAAAVLLAFGLALLSIWKFAGGKPRGAKYPNSLPCLPFIGSLLH-LASHLAPHILFNKLQEKYGSLYSFK-MGSHYIVIVNHHEHAKEVLLKKGKTFGGRPRAVTTDLLTRNAKDIAFA-DYSPTWKFHRKLVHAALSMFGEGTVAIEKIISREAASLCQTLITFQGSPLD----MAPELTRAVT-NVVCALCFNARYKRCDPEFEEMLAYSKGIVDTVAKDSLVDIFPWLQIFPNKDL-EILKRSVAIRDKLLQKKLKEHKEAFCGEEVNDLLDALLKAKLSMENNNSNISQEVG----LTDDHLLMTVGDIFGAGVETTTTVLKWTVAYLLHYPKVQAKIQEEL---DVKVGFGRHPVLSDRRILPYLDATISEVLRIRPVAPLLIPHVALHESSIGEYTIPQDARVVINLWSLHHDPNEWENPEEFIPDRFLDENGNHLYTPSQSYLPFGAGIRVCLGEALA-KMEIFLFLSWILQRFTL 470
BLAST of Cytochrome P450 2L1 vs. Ensembl Xenopus
Match: cyp17a1 (cytochrome P450 family 17 subfamily A member 1 [Source:NCBI gene;Acc:100145650]) HSP 1 Score: 132.109 bits (331), Expect = 2.067e-32 Identity = 125/484 (25.83%), Postives = 219/484 (45.25%), Query Frame = 2
Query: 122 FESSVFYLCLGIVAYIIYKWHF--PKKHNLPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLN-SVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTE--ISNNAYELFATHIREKKELVSDGGFYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNLAFFDITP-LNCLPHPGKNKILEYSKYLSDKV-QKHIKERKSD-GNYKVNPKYFIDYCI--EIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDK--LHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGK-FQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKI 1534
+ ++ L G+ I+K+ P+ P P IGS+ +S L+ L +EKYG + FK MG +++ + ++ + + GRP + D L+ ++I F W RK + L E E IS A L T I + + +L V N++ + + + +P +++ ++ ++ V + DI P L P+ +IL+ S + DK+ QK +KE K +VN +++N ++ G LTD + DI+ AG++ WT+ L +P+VQ I++EL D++ + + D+ L YL+A ++EV+RI ++ H A+ + +GEY IP+D + +N++ H+D W+NP EF PDRF++ +G +P + ++PFG G R C+ E K F+F I Q F +
Sbjct: 4 YVAAAVLLAFGLALLSIWKFAGGKPRGAKYPNSLPCLPFIGSLLH-LASHLAPHILFNKLQEKYGSLYSFK-MGSHYIVIVNHHEHAKEVLLKKGKTFGGRPRAVTTDLLTRNAKDIAFA-DYSPTWKFHRKLVHAALSMFGEGTVAIEKIISREAASLCQTLITFQGSPLD----MAPELTRAVT-NVVCALCFNARYKRCDPEFEEMLAYSKGIVDTVAKDSLVDIFPWLQIFPNKDL-EILKRSVAIRDKLLQKKLKEHKEAFCGEEVNDLLDALLKAKLSMENNNSNISQEVG----LTDDHLLMTVGDIFGAGVETTTTVLKWTVAYLLHYPKVQAKIQEEL---DVKVGFGRHPVLSDRRILPYLDATISEVLRIRPVAPLLIPHVALHESSIGEYTIPQDARVVINLWSLHHDPNEWENPEEFIPDRFLDENGNHLYTPSQSYLPFGAGIRVCLGEALA-KMEIFLFLSWILQRFTL 470
BLAST of Cytochrome P450 2L1 vs. Ensembl Xenopus
Match: ENSXETT00000013080.1 (pep primary_assembly:Xenopus_tropicalis_v9.1:8:57516124:57531831:-1 gene:ENSXETG00000004600.1 transcript:ENSXETT00000013080.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 131.724 bits (330), Expect = 2.804e-32 Identity = 128/482 (26.56%), Postives = 214/482 (44.40%), Query Frame = 2
Query: 119 LFESSVFYLCLGIVAYIIYKWHFPKKHNLPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGR-PLNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTE--ISNNAYELFATHIREKKELVSDGGFYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGK---LMAKV-GNLAFFDITPLNCLPHPGKNKILEYSKYLSDKVQKHIKERKS--DGNYKVNPKYFID-YCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKI 1534
LF+ ++ L ++ +++ + LPPGP P IG++ + L K L+ D +KYG + F V + Y++ +A + D++ E +GR +V S GN ++ T W +LR+ + L+ ++ E + A L A R + D F G NI+ + + D ++ NP + + + +I LM+ G L F + +P P K Y K L V K +K K D N NP+ FID + I+IQ +K + +L +++++FAG + G + +L HP+V++ ++ E+ K N S K+ Y AV+ E++R + + H D++ Y +PK I I + YD +KNP F+P F++ + F+ EGFM F G+R CV E E FIF I Q+FK+
Sbjct: 2 LFQGTLVLFLLFLITFMLMLSKKKHRGRLPPGPVPLPYIGNMHQVKINDL-IKSLV-DLSKKYGPMYTFYLGSRPTVVLCGYQILKEALI-DHAEEFSGRGEFPAVQMYSKGNGIVYGT---GERWRQLRRFAITTLKNFGMGKRSLEERVKEEAQYLIA-EFRNSEGEPFDPTFGFSS----AGSNIICSLVFGDRFDYRNPEFLNLLYLINNSWHLMSSTWGQLLFVFPKIMQLIPGPHKKIYKNYLK-LGAFVAKRLKMNKETLDPN---NPRDFIDCFLIKIQQEKKNPDSHFNYETMLKT------TVNVFFAGTETVGSTLRYGFLILLKHPEVEEKVQGEIDKVIGRN-RSPCMDDRSKMPYTEAVIYEILRFADIVPMSVPHTVTRDIEFRGYTLPKGLNIMPLICTSQYDVTKFKNPASFDPAHFLDENMDFKK-NEGFMAFSAGKRICVGEGLAQMEL-FIFFTTILQNFKL 459
BLAST of Cytochrome P450 2L1 vs. Ensembl Xenopus
Match: ENSXETT00000012497.1 (pep primary_assembly:Xenopus_tropicalis_v9.1:8:57516124:57531180:-1 gene:ENSXETG00000004600.1 transcript:ENSXETT00000012497.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 131.339 bits (329), Expect = 3.931e-32 Identity = 128/485 (26.39%), Postives = 214/485 (44.12%), Query Frame = 2
Query: 122 FESSVFYLCLGIVAYIIYKWHFPKKHNLPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGR-PLNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTE--ISNNAYELFATHIREKKELVSDGGFYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGK---LMAKV-----GNLAFFDITPLNCLPHPGKNKILEYSKYLSDKVQKHIKERKS--DGNYKVNPKYFID-YCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKI 1534
F S++ L ++ +++ + LPPGP P IG++ + L K L+ D +KYG + F V + Y++ +A + D++ E +GR +V S GN ++ T W +LR+ + L+ ++ E + A L A R ++ GF G NI+ + + D ++ NP + + + +I LM+ L FF + +P P K Y K L V K +K K D N NP+ FID + I+IQ +K + +L +++++FAG + G + +L HP+V++ ++ E+ K N S K+ Y AV+ E++R + + H D++ Y +PK I I + YD +KNP F+P F++ + F+ EGFM F G+R CV E E FIF I Q+FK+
Sbjct: 3 FNSTLVLFLLFLITFMLMLSKKKHRGRLPPGPVPLPYIGNMHQVKINDL-IKSLV-DLSKKYGPMYTFYLGSRPTVVLCGYQILKEALI-DHAEEFSGRGEFPAVQMYSKGNGIVYGT---GERWRQLRRFAITTLKNFGMGKRSLEERVKEEAQYLIA-EFRNREPFDPTFGFSS------AGSNIICSLVFGDRFDYRNPEFLNLLYLINNSWHLMSSTWGQVSQTLIFFLSKIMQLIPGPHKKIYKNYLK-LGAFVAKRLKMNKETLDPN---NPRDFIDCFLIKIQQEKKNPDSHFNYETMLKT------TVNVFFAGTETVGSTLRYGFLILLKHPEVEEKVQGEIDKVIGRN-RSPCMDDRSKMPYTEAVIYEILRFADIVPMSVPHTVTRDIEFRGYTLPKGLNIMPLICTSQYDVTKFKNPASFDPAHFLDENMDFKK-NEGFMAFSAGKRICVGEGLAQMEL-FIFFTTILQNFKL 461
BLAST of Cytochrome P450 2L1 vs. Ensembl Mouse
Match: Cyp17a1 (cytochrome P450, family 17, subfamily a, polypeptide 1 [Source:MGI Symbol;Acc:MGI:88586]) HSP 1 Score: 135.961 bits (341), Expect = 7.506e-34 Identity = 113/445 (25.39%), Postives = 201/445 (45.17%), Query Frame = 2
Query: 227 PIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRP-LNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTEI----SNNAYELFATHIREKKELVSDGGFYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNLAFFDITP-LNCLPHPGKNKILEYSKYLSDKVQKHIKERKSDGNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLP-ILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKEL-QKNDIENVESFNYKMMDKLHYL--NAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGK-FQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDF 1528
P++GS+P + + +EKYG I + V V Y+L + VK E +GRP + ++ LS + + F S + W RK + + QK+ ++ +N+ +L T+ E ++L + L + NI+ + + + E +P + ++ +G+ DI P L P+ I E++K + + ++ K N + + D I+ + N + GQ P + +D I DI+ AG++ +W + L +P+V+ I+KE+ Q SFN D+ H L A + EV+RI ++ H+A D +GE+ IPKDT + +N++ H+D W P+ F P+RF++ G +P ++PFG G R+C+ E ++ FIF + Q F
Sbjct: 35 PLVGSLPFLPRRGHMHANFFK-LQEKYGPIYSLRLGTTTAVIVGHYQLAREVLVKK-GKEFSGRPQMVTLGLLSDQGKGVAFADS-SSSWQLHRKLVFSTFSLFRDDQKLEKMICQEANSLCDLILTYDGESRDLST--------LIFKSVINIICTICFNISFENKDPILTTIQTFTEGIVDVLGHSDLVDIFPWLKIFPNKNLEMIKEHTKIREKTLVEMFEKCKEKFNSE-SLSSLTDILIQAKMNAENNNTGEGQDPSVFSDKHILVTVGDIFGAGIETTSSVLNWILAFLVHNPEVKRKIQKEIDQYVGFSRTPSFN----DRTHLLMLEATIREVLRIRPVAPLLIPHKANIDSSIGEFAIPKDTHVIINLWALHHDKNEWDQPDRFMPERFLDPTGSHLITPTPSYLPFGAGPRSCIGEALA-RQELFIFMALLLQRF 462
BLAST of Cytochrome P450 2L1 vs. Ensembl Mouse
Match: Cyp2d22 (cytochrome P450, family 2, subfamily d, polypeptide 22 [Source:MGI Symbol;Acc:MGI:1929474]) HSP 1 Score: 131.339 bits (329), Expect = 3.195e-32 Identity = 119/490 (24.29%), Postives = 215/490 (43.88%), Query Frame = 2
Query: 113 TDLFESSVFYLCLGIVAYIIYKWHFPKKHNLPPGPKAWPIIGSI--PDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRP-LNSVDRLSVG--NENIFFTRSLDAGWTELRKQIMIM----LRKVAEPQKMTEISNNAYELFATHIREKKELVSDGGFYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNLAFFDITPLNCLPH----PG-KNKILEYSKYLSDKVQKHIKERKSDGNYKVNPKYFID-YCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKIT 1537
+L+ ++F + I+ +++ W + PPGP WP++G++ D + P +++L + +YG++ + + V ++ +A VK +S + A RP L+ D L G ++ I R A + R + M L K + Q +TE + FA H S + +C N++ + + E+D+P + I ++G L + A F LN P PG K+ + + + + E K+ + P+ D + E++ + + + D + + D++ AGM SW + L+ HP VQ +++E+ + I V+ ++ Y NAV++EV R + H+ D+++ + IPK T + N+ A D W+ P F+P+ F++A G F P E FMPF GRR+C+ E E FT + Q F I+
Sbjct: 7 AELWPIAIFTVIFLILVNLMH-WRQRWTAHYPPGPMPWPVLGNLLHMDFQNMPAGFQKL----RGRYGDLFSLQLASESVVVLNGLTALREALVK-HSEDTADRPPLHFNDLLGFGPRSQGIVLARYGPAWRQQRRFSVSTMHHFGLGKKSLEQWVTEEARCLCAAFADHTGHP---FSPNTLLDKAVC-----NVIASLLYACRFEYDDPRF---IRLLGLLKETLKEEAGFLPMFLNVFPMLLRIPGLVGKVFPGKRAFVTMLDELLAEHKTTWDPTQPPRDLTDAFLAEVEKAKGNPESSF------NDENLRTVVGDLFSAGMVTTSTTLSWALMLMILHPDVQRRVQQEIDEV-IGQVQCPEMADQARMPYTNAVIHEVQRFADILPLGVPHKTSRDIELQGFLIPKGTTLITNLSSALKDETVWEKPLCFHPEHFLDAQGHFVKP-EAFMPFSAGRRSCLGEPLARMELFLFFTC-LLQRFSIS 470
BLAST of Cytochrome P450 2L1 vs. Ensembl Mouse
Match: Cyp2j9 (cytochrome P450, family 2, subfamily j, polypeptide 9 [Source:MGI Symbol;Acc:MGI:1921769]) HSP 1 Score: 129.413 bits (324), Expect = 1.317e-31 Identity = 105/458 (22.93%), Postives = 204/458 (44.54%), Query Frame = 2
Query: 191 KKHNLPPGPKAWPIIGSI--PDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTE--ISNNAYELFATHIREKKELVSDGGFYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNLA--FFDITPLNCLPHPGKNKIL-----EYSKYLSDKVQKHIKERKSDGNYKVNPKYFID-YCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDF 1528
+ N PPGP P +G + DP LS ++ ++ KYG ++ + V ++ L + F + N RP+ + + + F S D W E R+ ++ LR ++ E I A+ L IR++ D F + NI+ + + + ++ + +Q+ + ++ + M ++ ++I P PG ++ L + ++SD V H ++ D P+ FID + E+ + + + ++ +LD++FAG + W + +A +P+VQ+ ++ E+ + I N D + Y NAV++EV R+ ++ F D ++ +++PK ++ N+ H D W P+ FNP+ F+ +G+F+ +E F+PF +G+R C+ E+ E FIF + Q F
Sbjct: 39 RPKNYPPGPMRLPFVGCLFHLDPKQPHLSLQQFVK----KYGNVLSLDFANIPSVVITGMPLIKEIFTQMEHN-FMNRPVTLLRKHLFNKNGLIF--SSDQTWKEQRRFALMTLRNFGLGKRSLEERIQEEAHYLVEA-IRDEGGQPFDPHFNISNAV----SNIICSITFGERFDYHDSQFQEMLRLLDEAMCLESSMMCQLYNIFPRILQYLPGSHQTLFRNWRKLQLFVSDIVNNHRRDWDPD-----EPRDFIDAFLTEMTKYPDKTTTSFNEENLICS------TLDLFFAGTETTSTTLRWALLCMALYPEVQEKMQAEIDRV-IGQARQPNLADRDSMPYTNAVIHEVQRMGNIIPFNVPREVAVDTQLAGFNLPKGIMVLSNLTALHRDPSEWTTPDTFNPEHFLE-NGQFKK-RESFLPFSMGKRACLGEQLARSEL-FIFITTLFQKF 469
BLAST of Cytochrome P450 2L1 vs. Ensembl Mouse
Match: Cyp2j11 (cytochrome P450, family 2, subfamily j, polypeptide 11 [Source:MGI Symbol;Acc:MGI:2140224]) HSP 1 Score: 129.413 bits (324), Expect = 1.346e-31 Identity = 115/463 (24.84%), Postives = 210/463 (45.36%), Query Frame = 2
Query: 191 KKHNLPPGPKAWPIIGSIPDPYSSPLSYKRL---IEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLNSVDRLSVG-------NENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTE--ISNNAYELFATHIREKKELVSDGGFYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNL--AFFDITP--LNCLPHPGKNKILEYSKYLSDKVQKHIKERKSDGNYKVNPKYFID-YCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDF 1528
+ N PPGP+ P +G++ + L RL I+ + +KYG +I +NF Y+S + +K+ + G N + R S+ N I F+ W E RK + +L+ +K E I AY L I E+K D F + VG NI+ + + + E+D+ +Q+ + + +++ ++ +++ P LP P + K+ + L V + + + D N P+ FID + E+ + + + ++ +LD++FAG + W + + +P+VQ+ + E+ + I + D + Y NAV++EV+R+ ++ +D + + +PK T++ +N+ H D K W PN FNP+ F+ +G+F+ KE F+PF +G+R C E+ E FIF + Q F
Sbjct: 39 RPKNYPPGPRRLPFVGNL---FQFDLDVSRLHLGIQPFVKKYGNVI-----SVNFGYISSVIISGLPLIKE---AITGMEQNFLKRPSLAARQHVFKNNGIVFSSG--QTWKEQRKFALTILKNFGLGKKSLEQCIQEEAYHLVKA-IGEEKGQPFDPHFRINNA---VG-NIICSIIFGERFEYDDNQFQELLKLADEIICSEASMMSVLYNVFPSIFKYLPGP-QQKLFSNWEKLKLFVSRMMDSHREDWNPSA-PRDFIDAFLTEMTKYPDKTTTSFNEENLICT------ALDLFFAGTETTSNTLRWALLYITVNPEVQEKVHSEIDR-VIGHGRHPTLDDQDSMPYTNAVIHEVLRMGNIIPLNVPREVTADSTLAGFYLPKGTMVLINLTDLHRDPKEWDTPNVFNPEHFLE-NGQFKK-KESFLPFSMGKRACPGEQLASCEL-FIFFTALMQKF 471
BLAST of Cytochrome P450 2L1 vs. Ensembl Mouse
Match: Cyp2j5 (cytochrome P450, family 2, subfamily j, polypeptide 5 [Source:MGI Symbol;Acc:MGI:1270149]) HSP 1 Score: 124.79 bits (312), Expect = 4.565e-30 Identity = 119/499 (23.85%), Postives = 223/499 (44.69%), Query Frame = 2
Query: 89 ILYKIKMLTDLFES-SVFYLCLGIVAYI----IYKWHFPKKHNLPPGPKAWPIIGSI--PDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTE--ISNNAYELFATHIREKKELVSDGG--FYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNLAFFDITPLNC----LPHPGKNKILEYSK---YLSDKVQKHIKERKSDGNYKVNPKYFID-YCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDF 1528
I++ ++T +E+ + L L +V ++ I + PK N PPGP P +G+ D + L +++ + +KYG + + V VS L + F N R + V G + + W E R+ ++ LR +K E I + L IRE +GG F NI+ V + + ++++ +Q+ + ++ + M +G+ A C LP P + + K ++S V+KH K+ D P+ FID + IE+Q + ++ + + +++ +LD++ G + W + ++++P++Q+N++ E+ + I + + + + Y NAV++EV R+ ++ S D K + +PK T+I N+ H D K W P FNP+ F+ +G+F+ +E F+PF +G+R C+ E+ K FIF + Q F
Sbjct: 2 IMFLSSLVTTFWEALHLKTLVLAVVTFLFLINILRSRHPK--NYPPGPWRLPFVGNFFQIDTKQTHL----VLQQFVKKYGNVFSLELGQSPVVVVSGLPLIKEMFTHLDQN-FVNRFMTPVRERITGKNGLVVSNG--QTWKEQRRLALMALRNFGLGKKSLEERIQEETHHLVEA-IRE------EGGQPFNPHLKLINAVSNIICSVTFGERFDYEDCQFQELLQLLDETMHLMGSSAGQLYNGFPCIMKYLPGPHQKIFRNWGKLKLFVSHIVKKHEKDWNPD-----EPRDFIDAFLIEMQKD-PDRTTSFNEENLIST------TLDLFLGGTETTSSTLRWALLYMSSYPEIQENVQAEIDR-VIGHKRQVSLSDRESMPYTNAVIHEVQRMGNIVPLNSSREVTVDTKFNGFHLPKGTMILTNLTALHRDPKEWATPEVFNPEHFLE-NGQFKK-RESFLPFSMGKRACLGEQL-AKSELFIFFSALMQKF 468
BLAST of Cytochrome P450 2L1 vs. UniProt/SwissProt
Match: sp|Q09653|C13AA_CAEEL (Putative cytochrome P450 CYP13A10 OS=Caenorhabditis elegans OX=6239 GN=cyp-13A10 PE=3 SV=3) HSP 1 Score: 152.525 bits (384), Expect = 9.379e-39 Identity = 123/487 (25.26%), Postives = 215/487 (44.15%), Query Frame = 2
Query: 143 LCLGIVAYIIYKWHFPKKHNLPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTEISNNAYELFATHIREKKELVSDGG------FYVEQLCYWVGHNILVQVFWEDAVEFDNP----------NYQDTISVIGKLMAKVGNLAFFDITPLNCLPHPGKNKILEYSKYLSDKVQKHIKERKSDGNYKVN---PKYFIDYCIEIQDNQKE----------QKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYW-KNPNEFNPDRFI--NADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFT 1507
L +G ++Y ++ W + ++ +P GP +P++GS P S I DW + YG I + + + + VSD + Q FV+ Y N GR LN + +E + W LR + + + ++A EL +R +E S+G FY E +G + Q D+ F NP + + I +IG + + + F + P G + +K + VQ I +R++D + P+ FID +E + + E + YG + T + L AG D + S+T LLATHP+VQ +++E+++ IE SF++ + KL Y++ ++ E +R++ L + + R M K+G ++ T++ ++ + H D+K W + EF P+R++ N D FQ K G++ FG+G R CV R E +
Sbjct: 11 LFIGFISYYLWIWTYWRRRGIP-GPLGYPLVGSFPKTLKSEYPQYLQIRDWTKLYGPIYGYTEGTIKTLIVSDIDIVRQIFVEQYDN-FYGRKLNPIQGDPEKDERTNLFSAQGFRWKRLRAISSPTFSNNSLRKINVTVEDSAMEL----LRHIEEQTSEGQQIDMLQFYQEFTMDTIGRIAMGQT---DSQMFKNPLLKFVRAIFGDNRKHIPLIGGVFPTLAQVFRFFMLKF---PLLGAANFIHVNKTVVTAVQNRIDQRENDRKNGIEIGEPQDFIDLFLEARADDVEHFQENNGDFSKTSSYGNRQLTTQEIVGQ-CLVFLIAGFDTTALSLSYTTFLLATHPEVQKKLQEEIERECIEPSISFDH--LSKLKYMDCIIKETLRLYPLGTMANSRRCMRATKLGNVEVEVGTMVQVDTWSLHTDTKIWGDDAKEFKPERWLDPNCDQVFQ--KGGYISFGLGPRQCVGMRLAYMEEKMLLA 480
BLAST of Cytochrome P450 2L1 vs. UniProt/SwissProt
Match: sp|Q92113|CP17A_SQUAC (Steroid 17-alpha-hydroxylase/17,20 lyase OS=Squalus acanthias OX=7797 GN=CYP17A1 PE=2 SV=1) HSP 1 Score: 146.747 bits (369), Expect = 9.712e-37 Identity = 129/492 (26.22%), Postives = 220/492 (44.72%), Query Frame = 2
Query: 107 MLTDLFESSVFYLCLGIVAYIIYKWHFPKKHNLPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNF-VYVSDYKLGYQAFVKDYSNELAGRP-LNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTE--ISNNAYELFATHIR---EKKELVSDGGFYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNLAFFDITP-LNCLP----HPGKNKILEYSKYLSDKVQKHIKERKSDGNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKN-DIENVESFNYKMMDK--LHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKF-QSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKI 1534
ML L + F +C + + K LP ++P+IGS+ S L L + ++ YG + MG ++ V +++++ + +K AGRP + + D LS G ++I F + W RK ++ L + E I A + +T R +++ D V N++ + + E ++P +Q ++ V + DI P L P H K I L K + H SD + + ++ + N + + + D + ++ DI+ AG++ F+W I L HP+VQ I++E+ N E KM DK +++LNA ++E++RI +S H A++D +G+Y IPK T + +N++ H+D K WKNP+ F+P RF++ DGK+ S E ++PFG G R C+ E E F+FT I Q F +
Sbjct: 4 MLAALILTVAFVIC-SLTGFTQRKL---SGGRLPKCLPSFPLIGSLLS-LRSDLPPHLLFQKLQKTYGNLFSL-MMGPHYAVVINNHQHAKEVLLKK-GKIFAGRPSMVTTDLLSRGGKDIAFGK-YGPAWKFHRKLVLSALHLFGDGSAGIEKMICQEATSMCSTFERLNNAAHDMMPDVTRAVT--------NVICLLCFNSTYEKEDPEFQTMRKYSQGIVNTVAKDSLIDIFPWLQFFPNENLHTLKQCIATRDSILQKKFEDHKANYSSD-----SANDLFNILLKAKMNAENNNSSVHEAGLTDDHMVMTVA-DIFGAGVETSSTAFAWMIIYLIHHPEVQKKIQEEIDSNIGFERTP----KMSDKGNMNFLNATIHEILRIQPVSPLLIPHVALADSSIGDYTIPKGTRVIINLWAIHHDEKEWKNPDAFDPGRFLDEDGKYVCSSSESYLPFGAGTRVCLGEMLARMEL-FLFTSWILQRFTV 468
BLAST of Cytochrome P450 2L1 vs. UniProt/SwissProt
Match: sp|P37123|C77A1_SOLME (Cytochrome P450 77A1 (Fragment) OS=Solanum melongena OX=4111 GN=CYP77A1 PE=2 SV=1) HSP 1 Score: 144.436 bits (363), Expect = 5.578e-36 Identity = 122/479 (25.47%), Postives = 213/479 (44.47%), Query Frame = 2
Query: 191 KKHNLPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLNSVDRLSVGNENIFFTRSLDAG--WTELRKQIMIMLRKVAEPQKMTEISNNAYELFATHIREKKELVSDGGFYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNLAFFDITPLNCL--PHPGKNKILEYSKYLSDKVQKHIKERKS----DGNYKVNPKY-FIDYCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINA--DGKFQSPKE-GFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFK-ITWSSKNKTDKVEEDLENT 1588
K NLPPGP WPI+G++ S + I D K KYG I K + V+ +L ++A ++ A RP + R ++ + N F + G W LR+ ++ + + ++ E A + IR + +D + ++ + V + ++ F VE DN + + + K + V + D P+ L + + ++ E K + + I++R+S G+ K + ++D +++ ++ +L L F++ G D W IG L +P +Q+ + +E++ I + + ++K+ YLNAVV E++R H + FT H VK+ YDIP DT + ++G +D W +P +F+PDRF++ D KE MPFGVGRR C + + R+ Q+F+ + NK D E LE T
Sbjct: 23 KTPNLPPGPPGWPIVGNLFQVAGSGKQFFEYIRDLKPKYGSIFTLKMGSRTMIIVASAELAHEALIQK-GQIFASRPRENPTR-TIFSCNKFSVNAAVYGPVWRSLRRNMVQNMLSPSRLKEFREFREIAMDKLIERIRVDAKENNDVVWALKNARFAVFYILVAMCF---GVEMDNEEMIERVDQMMKDVLIVLDPRIDDFLPILRLFVGYKQRKRVNEVRKRQIETLVPLIEKRRSVVQNPGSDKTAASFSYLDTLFDVKVEGRKSGPTNAELVTLCSEFLN--------GGTDTTATALEWGIGRLMENPTIQNQLYQEIKT--IVGDKKVDENDIEKMPYLNAVVKELLRKHPPTYFTLTHSVTEPVKLAGYDIPMDTNVEFFVHGISHDPNVWSDPEKFDPDRFLSGREDADITGVKEVKMMPFGVGRRICPGLGMATVHVNLML-ARMVQEFEWFAYPGNNKVD-FSEKLEFT 484
BLAST of Cytochrome P450 2L1 vs. UniProt/SwissProt
Match: sp|Q96514|C71B7_ARATH (Cytochrome P450 71B7 OS=Arabidopsis thaliana OX=3702 GN=CYP71B7 PE=1 SV=1) HSP 1 Score: 143.665 bits (361), Expect = 1.008e-35 Identity = 123/461 (26.68%), Postives = 194/461 (42.08%), Query Frame = 2
Query: 140 YLCLGIV----AYIIYKWHFPKKHNLPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTEISNNAYELFATHIRE----------KKELVSDGGFYVEQLCYWVGHNILVQVFWEDAVEF-DNPNYQDTISVIGKLMAKVGNLAFFDITPLNCLPHPGKNKIL-----EYSKYLSDKVQKHIKERKSDGNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTC 1462
+LCL V I+ K P K LPPGPK PIIG++ + P + R + +K+G ++L G V V K G + +K E RP R+ N W LRK +++ L + Q I +L + E KK L + V +L + G NI EF D N D ++ L+A V FF G+NK L E + + + HIK + NP +D +++ Q++ E + LT + + DI+ AG++ + +W + L +P+V ++ E++ + + + + ++HY VV E+ R+H + MS VK+ YDIP T + +NIY D K W NP+EFNPDRF+++ ++ +PFG GRR C
Sbjct: 7 FLCLLPVFLVSLSILSKRLKPSKWKLPPGPKTLPIIGNLHNLTGLPHTCFR---NLSQKFGPVMLL-HFGFVPVVVISSKEGAEEALKTQDLECCSRPETVATRMISYNFKDIGFAPYGEEWKALRKLVVMELLNTKKFQSFRYIREEENDLLIKKLTESALKKSPVNLKKTLFTLVASIVCRLAF--GVNI-------HKCEFVDEDNVADLVNKFEMLVAGVAFTDFFPGVGWLVDRISGQNKTLNNVFSELDTFFQNVLDDHIKPGRQVSE---NPDV-VDVMLDLMKKQEKDGESFK----LTTDHLKGIISDIFLAGVNTSAVTLNWAMAELIRNPRVMKKVQDEIRTTLGDKKQRITEQDLSQVHYFKLVVKEIFRLHPAAPLLLPRETMSHVKIQGYDIPVKTQMMINIYSIARDPKLWTNPDEFNPDRFLDSSIDYRGLNFELLPFGSGRRIC 446
BLAST of Cytochrome P450 2L1 vs. UniProt/SwissProt
Match: sp|P11715|CP17A_RAT (Steroid 17-alpha-hydroxylase/17,20 lyase OS=Rattus norvegicus OX=10116 GN=Cyp17a1 PE=1 SV=2) HSP 1 Score: 141.354 bits (355), Expect = 7.035e-35 Identity = 120/482 (24.90%), Postives = 212/482 (43.98%), Query Frame = 2
Query: 203 LPPGPKAWPIIGSIP-DPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRP-LNSVDRLSVGNENIFFTRSLDAG--WTELRKQIMIMLRKVAEPQKMTE-ISNNAYELFATHIREKKELVSDGGFYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNLAFFDITP-LNCLPHPGKNKILEYSKYLSDKVQKHIKERKSDGNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLP-ILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKEL-QKNDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGK-FQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKITWSSKNKTDKVEEDLENTFFRHTAPFYVE 1621
LP + P++GS+P P + +EKYG I + V + Y+L + +K E +GRP + + LS + + F DAG W RK + + QK+ + I A L + KE + + + NI+ + + + E ++P + ++ G+ DI P L P+ G I Y+K + ++V I E+ + + D I+ + N G+ P + +D I DI+ AG++ W + L +P+V+ I+KE+ Q +FN + L L A + EV+RI ++ H+A D +GE+ +PKDT + +N++ H+D W P++F P+RF++ G +P + ++PFG G R+C+ E ++ F+FT + Q F + S + ++E D + F PF V+
Sbjct: 27 LPRSLPSLPLVGSLPFLPRRGHMHVNFF--KLQEKYGPIYSLRLGTTTTVIIGHYQLAREVLIKK-GKEFSGRPQMVTQSLLSDQGKGVAFA---DAGSSWHLHRKLVFSTFSLFKDGQKLEKLICQEAKSLCDMMLAHDKESID-----LSTPIFMSVTNIICAICFNISYEKNDPKLTAIKTFTEGIVDATGDRNLVDIFPWLTIFPNKGLEVIKGYAK-VRNEVLTGIFEKCREKFDSQSISSLTDILIQAKMNSDNNNSCEGRDPDVFSDRHILATVGDIFGAGIETTTTVLKWILAFLVHNPEVKKKIQKEIDQYVGFSRTPTFNDR--SHLLMLEATIREVLRIRPVAPMLIPHKANVDSSIGEFTVPKDTHVVVNLWALHHDENEWDQPDQFMPERFLDPTGSHLITPTQSYLPFGAGPRSCIGEAL-ARQELFVFTALLLQRFDLDVSDDKQLPRLEGDPKVVFL--IDPFKVK 491
BLAST of Cytochrome P450 2L1 vs. TrEMBL
Match: A0A1I8HZ60 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=4 SV=1) HSP 1 Score: 168.318 bits (425), Expect = 4.629e-42 Identity = 129/484 (26.65%), Postives = 231/484 (47.73%), Query Frame = 2
Query: 143 LCLGIVAYIIYKWHFPKKHNLPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKV--AEPQKMTEISNNAYELFATHIREKKELVSDGGFYVEQLCYWV--GHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAK---VGNLAFFDITPLNCLPHPGKNKILEYSKYLSDKVQKHIKER-KSDGNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDK--LHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKITWSSKNKTDK 1564
L + AY++Y W + +LPPGP P+IG +P ++ P + ++ EKYG+I F F+ ++ Y + + + DY+ AGRP + + I FT W++ R+ + LR A Q + + + +F T + E V+ +E L ++ ++I+ ++ E ++P +Q +I KL+ + A F + P + ++ +YL ++K I++R K + P+ D I ++K + EK G ++ + + L+ + AG D W + +A +P+VQD ++ EL D +S +M D+ LHY +AV++E R SL++ FHRA+ + Y IP D I N+YG H+ +YW+ PNEF P+ F++ +G+++S +PF +GRR+CV E E FT I Q +++ + ++ K
Sbjct: 9 LSAALGAYVLYYWR--QGRDLPPGPVGLPLIGRLP--WTDPKNLHLTMQKVAEKYGDITSFYLGSRLFIVLNSYPM-MKEMLDDYN--FAGRPRLRLFLKLTRDCGIIFTEGY--MWSQHRRLSLRTLRDFGFARAQTVEMVDDQLDSIFQT-LDEAATSVTP----MEVLGTFILASNSIITEMTLGHRFERNDPEFQKVNKLIKKLLEEGIVQTASALFPAVERFIVLFPLSSSVVHDVEYLHSFIRKEIQQREKVMVDESTEPECLCDVYI----HEKRKAEKAGDFETFKEFQLIRVILEFFLAGTDTTARSIEWLLLYMAFYPEVQDRVQNEL---DSVIGQSRRPRMQDRTELHYTSAVIDETYRKASLAAIGVFHRAVEETHFHGYRIPSDAFIIPNVYGVHHRVEYWERPNEFYPEHFLDNEGRYRS-SPYLIPFLIGRRSCVGESLARMEIVLFFTA-IMQRYRVRPAPESAAKK 469
BLAST of Cytochrome P450 2L1 vs. TrEMBL
Match: A0A059VQG8 (CYP2 OS=Portunus trituberculatus OX=210409 GN=CYP2 PE=2 SV=1) HSP 1 Score: 167.933 bits (424), Expect = 6.632e-42 Identity = 131/501 (26.15%), Postives = 229/501 (45.71%), Query Frame = 2
Query: 152 GIVAYIIYKWHFPKKHNLPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRP----LNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTEISNNAYELFATHIREKKELVSDGGFYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNLAFFDITPL--NCLPHPGKNKILEYSKYLSDK------VQKHIKERKS--DGNYKVNPKYFID-YCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKITWSSKNKTDKVEEDLENTFFRHTAP 1609
++ ++++K F K LPPG P++G IP ++S +++ + D ++YG I L++ ++++DYKL +AF + E RP L +D G S W R+ + LR + + A + +RE + + + NI+ + + +N + + ++ L+ LA D P N +P ++++Y + + K ++ ++E K+ D N+ P+ ID Y +E++ + + + + ++ L +++ AG + F+W LA HPQVQ + E+ + + + ++ Y AV++EVMR SL +F H A SD ++G Y IPK +++ + HYDS+YW P EF P+R+++ +GKF KEGF+PFGVG+R CV E E FI T + Q F I K+ + DL FFR P
Sbjct: 9 AVLVFLLWK-TFSKPPGLPPGKWGLPLVGYIP--WTSK-NFEEQVMDLHQQYGNIFLWRMGTQLMIFINDYKLMKEAFSR---AEFIPRPDWDVLTLIDEAPHG-----IVSSSGILWHNNRRFTLRQLRDLGMGKSSL---VGAVQQQCLKLRETLAKGAGTAVVINHQLHLSVINIIWYMVASRQFDAENKRLHEFVDLLSDLVILSNRLAIKDFMPWMQNVMPDFLFKRLIKYHEMMDMKEKFLQFFREEVEEHKATLDPNH---PRDLIDSYLLEMEAKKDDPETTCSERDLMF------LMFEMFSAGSETTSNTFTWVCCYLAAHPQVQRKLHAEIDEV-LPSGALPTLAEKSRMPYTEAVIHEVMRACSLINFGVQHMAASDTQLGGYTIPKGAVVSTTVTAIHYDSRYWDRPEEFRPERWLDENGKFSMVKEGFLPFGVGKRVCVGESLARMEL-FILTTMVFQSFAIA-PPPGKSVNLTPDLSGFFFRKAMP 482
BLAST of Cytochrome P450 2L1 vs. TrEMBL
Match: A0A5N5TAB7 (Cytochrome P450 2L1 OS=Armadillidium nasatum OX=96803 GN=Anas_09148 PE=4 SV=1) HSP 1 Score: 167.162 bits (422), Expect = 1.600e-41 Identity = 140/506 (27.67%), Postives = 242/506 (47.83%), Query Frame = 2
Query: 143 LCLGIVAYIIYKWHFPKK-HNLPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRP----LNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVA--EPQKMTEISNNAYELFATHIREKKELVSDGGFYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNLAFFDITP--LNCLPHPGKNKI-LEYS-KYLSDKV----QKHIKERKSDGNYKVNPKYFID-YCIEIQDNQKEQKEKY-GQLPILTDWFISNLSL----------DIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKITWSSKNKTDKVEEDL 1579
+ +G+V + + W+ KK + PPGP +PIIG IP+ ++ I ++++G I +K V+++D KL +AF + A RP L+ ++ S+G + W +LR+ + LR + + + ++ I EL HI+++ S + N+L Q+ +FD+ N +G+ + LAF D+ P + LP NKI L+Y K +SDK+ Q +I E K + + NP+ +ID Y IE++ + + G+ + F L + D++ AG++ + W + LAT P++Q+ + KE+ + + N + +L Y+ A + EV+R +L H M D K+G Y IPK++II H++ Y+++P EF P+RF+ A+GKF +P+EGF PFG+G+R C+ E E FIF + Q+F + D + D+
Sbjct: 6 ILIGLVIFTL--WNITKKPADYPPGPWGYPIIGYIPN---GKFGFEAKISQLRKEHGRIFCWKIGARILVFINDIKLIKEAF---QNITFANRPDIIFLSFLEDKSLG-----IVSTNGPHWHQLRRFSLRHLRDLGMGKSKIVSAIQFEVTEL-VNHIKKQ----SGKPAPFPNVLTMAVINVLWQMVASKRYDFDDENILAMHHDMGEAQRSLNRLAFLDMFPWIASVLPEALLNKITLKYKFKLVSDKMSKRFQAYIDEHKKTLD-ENNPRDYIDEYLIEMKRQESQPDSTMSGKFTYYKNTFSVILKIFKIDLIGCIADLFAAGLETTSMTTIWAVFYLATFPEIQEKVHKEID-SVLLNGTLVTIEDKSRLPYMEAFLTEVLRYSTLVPNGVPHTVMEDTKLGGYIIPKESIILTTTESFHFNPNYFESPEEFRPERFLTAEGKFSAPREGFFPFGIGKRQCLGESLARMEL-FIFLTSLAQNFSFSSPPGKNIDLIPADI 490
BLAST of Cytochrome P450 2L1 vs. TrEMBL
Match: A0A1I8J9E4 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=4 SV=1) HSP 1 Score: 167.162 bits (422), Expect = 1.685e-41 Identity = 128/478 (26.78%), Postives = 229/478 (47.91%), Query Frame = 2
Query: 161 AYIIYKWHFPKKHNLPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKV--AEPQKMTEISNNAYELFATHIREKKELVSDGGFYVEQLCYWV--GHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAK---VGNLAFFDITPLNCLPHPGKNKILEYSKYLSDKVQKHIKER-KSDGNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDK--LHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKITWSSKNKTDK 1564
AY++Y W + +LPPGP P+IG +P ++ P + ++ EKYG+I F F+ ++ Y + + + DY+ AGRP + + I FT W++ R+ + LR A Q + + + +F T + E V+ +E L ++ ++I+ ++ E ++P +Q +I KL+ + A F + P + ++ +YL ++K I++R K + P+ D I ++K + EK G ++ + + L+ + AG D W + +A +P+VQD ++ EL D +S +M D+ LHY +AV++E R SL++ FHRA+ + Y IP D I N+YG H+ +YW+ PNEF P+ F++ +G+++S +PF +GRR+CV E E FT I Q +++ + ++ K
Sbjct: 40 AYVLYYWR--QGRDLPPGPVGLPLIGRLP--WTDPKNLHLTMQKVAEKYGDITSFYLGSRLFIVLNSYPM-MKEMLDDYN--FAGRPRLRLFLKLTRDCGIIFTEGY--MWSQHRRLSLRTLRDFGFARAQTVEMVDDQLDSIFQT-LDEAATSVTP----MEVLGTFILASNSIITEMTLGHRFERNDPEFQKVNKLIKKLLEEGIVQTASALFPAVERFIVLFPLSSSVVHDVEYLHSFIRKEIQQREKVMVDESTEPECLCDVYI----HEKRKAEKAGDFETFKEFQLIRVILEFFLAGTDTTARSIEWLLLYMAFYPEVQDRVQNEL---DSVIGQSRRPRMQDRTELHYTSAVIDETYRKASLAAIGVFHRAVEETHFHGYRIPSDAFIIPNVYGVHHRVEYWERPNEFYPEHFLDNEGRYRS-SPYLIPFLIGRRSCVGESLARMEIVLFFTA-IMQRYRVRPAPESAAKK 494
BLAST of Cytochrome P450 2L1 vs. TrEMBL
Match: A0A2G8LNB2 (Putative steroid 17-alpha-hydroxylase/17,20 lyase OS=Stichopus japonicus OX=307972 GN=BSL78_01355 PE=3 SV=1) HSP 1 Score: 166.777 bits (421), Expect = 2.148e-41 Identity = 125/478 (26.15%), Postives = 219/478 (45.82%), Query Frame = 2
Query: 131 SVFYLCLGIVAYIIYKWHFPKKHNLPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLN-SVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVA--EPQKMTEISNNAYELFATHIREKKELVSDGGFYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNLAFFDITPL-NCLPHPGKNKIL----EYSKYLSDKVQKHIKERKSDGNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKN-DIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKIT 1537
++ + +V I+ P K + PPGPK WP++G+I D + + ++ ++YG+I + +G + V + + + E A RP + + D S G +I F + W RK RK+A + ++ ++ + ++ K D + Y NIL + + EFD+P + + + G+ D P+ +P PG+ K+ E+ ++S ++++H K DG PK F + Q Q+ + E + ++T+ I D++ AG D W +GL+ +P+VQ + +E+ + + + S N + ++L Y A + EVMR +++ H +DV+ G Y IPKDT I +NIY H+D K W P +F P+ F++ GK + EGF+PF GRR C+ E E IF +CQ +K +
Sbjct: 15 ALVTITTALVGIWIWSQQKPTK-DFPPGPKGWPLVGNIIDLARNEKPASVVFTEYAKEYGDIFSIR-VGQRWTVVLNGAATIKEALLKKGVEFANRPTSYTGDLFSEGGRDIAFGQ-YSPSWKLHRKLAFSAFRKLATGDNKRFEKLVYSIVPGLTANLDSKLSEPFDPRPILASSIY----NILTSLCFGKQYEFDSPELTRIMYLTKEANEIAGSGLLADYIPIFKYVPTPGQRKLEALFEEFLGFISQELEEH--HEKYDGG---EPKDFTEMLF--QSRQEIKDEGKEDMNLITETHIRQTVSDVFSAGTDTSIFTMHWCVGLMVQYPEVQAKVAEEVDRVVGRDRLPSLNDR--EELVYTTATLYEVMRYSTIAPLAVPHSTSTDVEFGGYTIPKDTWILVNIYSMHFDEKLWDEPKKFTPEHFLDESGKVRLHPEGFLPFSTGRRVCIGESVAKAELFLIF-AWLCQHYKFS 475
BLAST of Cytochrome P450 2L1 vs. Ensembl Cavefish
Match: ENSAMXT00000005525.2 (cytochrome P450 2J2-like [Source:NCBI gene;Acc:103037239]) HSP 1 Score: 145.976 bits (367), Expect = 1.705e-37 Identity = 120/480 (25.00%), Postives = 220/480 (45.83%), Query Frame = 2
Query: 128 SSVFYLCLGIVAYIIYKWHFPKKHNLPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLNSVDRLSVGNENIFFTRSLDA----GWTELRKQIMIMLRKVAEPQKMTEISNNAYELFATHIREKKELVSDGGFYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNL--AFFDITP--LNCLPHPGKNKILEYSKYLSDKVQKHIKERKSDGNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLPILTDWFISNL---SLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDK--LHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDF 1528
S+V + C+ ++ + P+ N PPGP P IG++ ++ + + + ++ EKYG + + G V V+ YKL + +V + + A RP+ + +IF + L A W + R+ + LR +K E S L ++ E F + L N++ + + E+ N +QD + ++ + G + +++ P + LP P + ++++ + + V+ + E K D ++ NP+ +ID +E + +K+ K D+ I NL ++D++ AG + W + + +P++Q + E+ D S MMD+ L Y NAV++E+ R+ ++ F DV++GEY IPK + N+ +D W+ P FNP F+N DG F+ +E FMPF G+R C+ E+ E F+F + Q F
Sbjct: 15 SAVLFFCVFLLLVEYLRNKAPR--NFPPGPPTLPFIGNLHTIDTTRIHLQFI--EFAEKYGNLFSIQIFGPRAVVVNGYKLVKELYV-NQGDHFADRPVFPL------FHDIFKDKGLVASSGYAWKQQRRFALTTLRNFGLGKKSLEPS---ILLECRYLIEAMSNEQGNRFNPQFLINNAVSNVICVLVFGSRFEYSNSEFQDLLKMMNQAFYLEGTIWAQMYNMVPRIMRRLPGPHQ-RVIQLWGNVFNYVRAKVDEHKMDRDFS-NPRDYIDCFLEEMEKRKDDKA--------ADFSIENLCFCAMDLFIAGTETTSTTLYWGLLYMTKYPEIQAKVHAEI---DQVVGSSRQPSMMDRDNLPYTNAVIHEIQRMGNIIPFNLARATSKDVQIGEYTIPKGASVFGNLTSVLFDETEWETPKSFNPGHFLNNDGSFRR-REAFMPFSAGKRVCLGEQLARMEL-FLFFSSLLQRF 465
BLAST of Cytochrome P450 2L1 vs. Ensembl Cavefish
Match: cyp1d1 (cytochrome P450 1A1-like [Source:NCBI gene;Acc:103022525]) HSP 1 Score: 145.976 bits (367), Expect = 2.593e-37 Identity = 131/507 (25.84%), Postives = 226/507 (44.58%), Query Frame = 2
Query: 140 YLCLGIVAYIIYKWHFPKK--HNLPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRP-LNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTEISNNAYELFATH--------IREKKELVSDGGFYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISV---IGKLMAKVGNLA-FFDITPLNCLPHPGKNKILEYSKYLSDKVQKHIKERKSDGNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKN-DIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKF-QSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKITWSSKNKTDKVEEDLENTFFRHTAP 1609
+LC+ + + + H K NLPPGP+AWP++G++ + + YG++ K + V +S QA V+ AGRP L + +S GN ++ F+ WT +K LR ++ + S+ E T +RE+ E V D G L N+ + + ++ + +++ + K+ A GNLA FF + LP P K+++Y ++ ++ HIKE + K + D IE+ ++++E ++K +LTD I + +DI+ AG D G W++ L P ++ I +E+ + + +F K K+ Y A + EV R S FT H ++ + Y IPKDT + +N Y ++D + W +P+ F P+RF++ + + E + FG+G+R CV +R+ E F+F + Q I +S E L TF P
Sbjct: 19 FLCIFTLFLLTLRLHQRKTLPSNLPPGPRAWPVVGNL---FQMGEQLHLSLTHLGAVYGDVFRVKMGSLEVVVLSGLSTIRQALVRQ-GEAFAGRPELFTFTAVSDGN-SMTFSEKYGEAWTLHKKICKNALRTFSQAKARNSSSSCLLEERITEEVLEMVEVLREQGEKVGDEGLDPTALLAISVANVACALCFGKRYSHNDEQFLTIVNINNEVLKIFAS-GNLADFFPV--FRYLPSPSLRKVVQYIHRMNCFMEDHIKEHLLSFD-KNCIRDITDALIELCEDRQEDRDK----AMLTDSQIIHTVIDIFGAGFDTIITGLQWSLLYLIKFPHIRTRICQEIDDQVGLNRLPTFEDKA--KMPYTEAFLYEVFRHASYMPFTLPHCTTENITLNGYFIPKDTCVFINQYQVNHDPEIWSDPDSFQPERFLSPSSQINKDVVEKVLIFGMGKRRCVGDRFARLE-MFMFLTTVLQRLHIESASAQ-----ELSLSTTFALTMKP 504
BLAST of Cytochrome P450 2L1 vs. Ensembl Cavefish
Match: cyp17a2 (cytochrome P450, family 17, subfamily A, polypeptide 2 [Source:ZFIN;Acc:ZDB-GENE-100822-1]) HSP 1 Score: 133.265 bits (334), Expect = 4.896e-33 Identity = 113/454 (24.89%), Postives = 201/454 (44.27%), Query Frame = 2
Query: 209 PGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNF-VYVSDYKLGYQAFVKDYSNELAGRP-LNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAE-PQKMTEISNNAYELFATHIREKKELVSDGGFYVEQLCYWVGH---NILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNLAFFDITP-LNCLPHPGKNKILEY----SKYLSDKVQKHIKERKSDGNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKIT 1537
PG + P++GS+ SPL +YG + + G N+ + VS+ L + + + AGRP + + ++ G ++I F W + R+ + E K+ I +A E + ++ + G +V+ LC + N++ ++ + + +P Q + ++ + DI P L P+ K+ E K L+ K+++H K + G P+ +D + Q + + +TD + + + + AG++ WTI L HPQVQD + EL + + L +L++ + EVMRI +S H AM D +G + +PK T + +N++ H+D K+W+ P++F PDRF++A GK +P F+PFG G R CV E E F+F + Q F +
Sbjct: 39 PGLPSVPVLGSLLH-MRSPLPPHLFFTRLAGRYGPLFSLRA-GRNYTLVVSEVGLAREVLLH-RGRDFAGRPQMVTTALMTRGGKDIAFA-DYSPLWKKHRRLVHSSFTLFGEGSSKLQNIVLDAAESLCSDLQACR------GQHVD-LCPMLMRAVTNVVCRLVFNSSYRPHDPELQQVMDYNDGIVQTIARGGLVDIFPWLQIFPNKDLAKLRECVSIRDKLLTKKLEEH-KLTYTPGE----PRDLLDALLIGQSGSAGEDD-------ITDDHVLMTAAEAFGAGVETTSTTLLWTIAFLLHHPQVQDRLHAELDEQ-VGRDRPPALSDRSNLPFLDSALCEVMRIRPVSPILIPHVAMQDTSLGGHAVPKGTRVLVNMWAIHHDPKHWEEPDQFRPDRFLDATGKKIAPPS-FLPFGAGPRVCVGESLARMEL-FLFVSCLLQRFHFS 466
BLAST of Cytochrome P450 2L1 vs. Ensembl Cavefish
Match: cyp2r1 (vitamin D 25-hydroxylase [Source:NCBI gene;Acc:103038630]) HSP 1 Score: 132.88 bits (333), Expect = 7.632e-33 Identity = 118/481 (24.53%), Postives = 214/481 (44.49%), Query Frame = 2
Query: 122 FESSVFYLCLGI-VAYIIYKWHFPKKHNLPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRP-LNSVDRLSV--GNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTEISNNAYELFATHIREKKELVSDGGFYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGK---LMAKVGNLAFFDITPLNCLPHPGKNKILEYSKYLSDKVQKHIKERKSDGNYKVNPKYFID-YCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKITW 1540
F S+ CL + VA + K P+ PPGP P+IG+I P Y +++ E YG+I G++ V ++ Y + + S A RP L +++ G N + R GW E RK + R + M + + F I K F + L N+ V + +D+ ++Q I + + L A + + LP K+ + + D + + I ER S G + +P+++ID Y E++ + ++ + + + I ++ ++ AG + W + LA +P VQ+ + +E+ + + N + + ++ Y+ AV++EV+R ++ F D V Y IP+ T++ N+Y H+D KYW+ P F P+RF++ +G F ++ F+PF VGRR C+ E+ E F+F + Q F++ +
Sbjct: 25 FGCSLAVTCLLVLVARRLVKQRRPR--GFPPGPAPLPLIGNILSLAVEPHVY---MKNQSETYGQIFSLDLGGISTVILNGYD-AIKECLYHQSEVFADRPSLPLFQKMTKMGGLLNCKYGR----GWIEHRKLAVNSFRYFGSGEAMFQRISEECMFFVDAIDTHK----GKPFNPQHLVTNAVSNVTNLVIFGQRFTYDDRDFQHMIQIFSENVELAASAWAFLYNAFPWIEYLPFGKHQKLFRNANKVYDFLLQ-IIERFSQGRVQHSPRHYIDAYLDEMEQSAGDEATSFSR-----ENLIFSVG-ELIIAGTETTTNTLRWAMLYLALYPSVQEKVHREI--DSVLNGRAPTMEDKQRMPYVEAVLHEVLRFCNIVPLGIFRATSQDTVVRGYTIPRGTMVITNLYSVHFDEKYWREPGVFCPERFLDNNGNFMR-RDAFVPFSVGRRHCLGEQLARMEM-FLFFTTLLQRFRLQF 480
BLAST of Cytochrome P450 2L1 vs. Ensembl Cavefish
Match: cyp2n13 (cytochrome P450 2J6-like [Source:NCBI gene;Acc:103035066]) HSP 1 Score: 128.642 bits (322), Expect = 1.792e-31 Identity = 109/455 (23.96%), Postives = 212/455 (46.59%), Query Frame = 2
Query: 200 NLPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLNSV-DRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTE--ISNNAYELFATHIREKKELVSDGGFYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNL--AFFDITPLNCLPH-PGK-NKILEYSKYLSDKVQKHIKERKSDGNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDK--LHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKIT 1537
N P GP A P +G+I D +SP + L + K Y I + + ++ YK+ +A V N RP + + +R+ GN +F + W + R+ + LR +K E I ++ L R K + G + + NI+ Q+ + ++ + ++Q + + + G++ ++ P N + H PG+ N I +++S+ ++K++ + K++ + NP+ ++D + ++N + + + +D + +LD++ AG + W + LA +P++QD +++E+ D +S M DK + Y AV++E++R + + A D +G Y IPK T I ++ +D W+ PN FNP F++ +GKF ++ F+ F G+R C+ E+ E FT + Q F+ +
Sbjct: 36 NFPSGPLALPFLGNILD-IASPQPHIYLTKLGK-AYNNIFSMRIGQQKMILLTGYKMVKEALVNQTDN-FVDRPYSPLAERIYSGNGGLFTSNG--NLWKKQRRFALSTLRNFGLGKKTMELAICEESHFLLDEMDRHKGQAFDPSGLFNNAVS-----NIICQLVFGQRYDYADYDFQQMLKYTSEAIHLEGSIWGRLYESFP-NIMKHLPGRHNVIFSNYEHISEFIKKNLDKHKANLD-PSNPRDYMDSFLIEKENSHDPADGF------SDKNLVRCTLDLFLAGTETTTTSLGWALIYLAKNPEIQDKVQEEI---DRVIGQSRQPGMADKPNMPYTEAVIHEILRRGDIVPLSGPRVAAKDTTLGGYAIPKGTTIMPILHSVLFDEDEWETPNSFNPQHFLDKEGKFVR-RDAFLAFSAGKRVCLGEQLARMELFLFFTC-LFQKFRFS 467
BLAST of Cytochrome P450 2L1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000011205.1 (pep scaffold:Pmarinus_7.0:GL477378:108537:110066:1 gene:ENSPMAG00000010178.1 transcript:ENSPMAT00000011205.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 138.272 bits (347), Expect = 2.232e-35 Identity = 118/480 (24.58%), Postives = 210/480 (43.75%), Query Frame = 2
Query: 119 LFESSVFYLCLGIVAYIIYKWHFPKKH-NLPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTEISNNAYELFATHIREKKELVSDGGFYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVI-GKLMAKVGNLA-FFDITPLNCLPHPGKNKILEYSKYLSDKVQKHIKERKSDGNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDKLH---YLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKITW 1540
L ++F + ++ I+ + K+ + PPGPK P +G++ + P +++ ++YGE+ ++ V+VS Y+ + V +E A RP ++ G I F W + R+ + LR + E + A F ++K D + L VG NI+ + E+ + +QD + ++ L + G L +I P + PG +I+ S S + + I + + P ID + + + + + ++ L+LD++ AG + W + + HP++Q +E+ K V S M+ H YL+AV++E+ R ++ F + H +DVK +Y IPK TII +N+ D +WK P EF+P+ F++ DGKF P + F+PF G R C+ E K F+F + Q F+ W
Sbjct: 24 LISLAIFCIIFLVLRAILQEVKATKRPLDFPPGPKVIPFLGNV-SLFKKP---DVALDEVTKQYGEVCSVMVGKISMVFVSGYQAVKEVLVHQ-GHEFADRPNTPFNKKVNGGLGIIFA-PYGKYWMQHRRFTLSTLRNFGLGKSSIEQTIQAEVGFLIEAFKQKGSAFDPHY---DLNSAVG-NIICSMVKGKRYEYSDKQFQDFLHLVENNLQLQSGLLGTLCNIFPF-LMDFPGPQQIIFKSMAKSKQFIRDIISERHATRDPIKPMCLIDAYLSQLEKEDNPNSSFSEQSLIM------LALDLFIAGAETTSTTLRWGLLYMMMHPEIQAQCHEEIDKI----VGSDRLPCMEDRHSLPYLDAVIHEIQRFSNIVPFGAPHATTADVKFRQYLIPKGTIIMVNMKSVLSDENHWKTPYEFSPENFLDEDGKFVKP-DAFLPFSAGPRVCLGENLA-KMELFLFFASLLQHFEFYW 480
BLAST of Cytochrome P450 2L1 vs. Ensembl Sea Lamprey
Match: cyp1d1 (cytochrome P450, family 1, subfamily D, polypeptide 1 [Source:ZFIN;Acc:ZDB-GENE-041114-179]) HSP 1 Score: 125.561 bits (314), Expect = 5.449e-31 Identity = 111/446 (24.89%), Postives = 190/446 (42.60%), Query Frame = 2
Query: 209 PGPKAWPIIGSI----PDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTEISNNAYELFATHIREKKELVSDGGFY-------VEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIG-----KLMAKVGNLA-FFDITPLNCLPHPGKNKILEYSKYLSDKVQKHIKERKSDGNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPK--EGFMPFGVGRRTCVAERYTVKE 1489
PGP WPI+G+I PDP+ L R+ ++YG++ + V +S + +A VK+ + AGRP L + + FTR+ D W ++ LR E E E+ L GG V + V N++ + + +P + + ++G ++ GNL FF L +P+ + S L ++ HIKE S K + + D I + Q+ + G L+D + +LDI+ AG D G +W + L HP VQ +++E+ + I + ++ L + A + E+ R + FT H DV + IP+DT + +N++ ++D W +P F+PDRF++ DGK + + E FG+G+R C+ + +E
Sbjct: 59 PGPVRWPIVGNILQLWPDPH---LKLTRMC----DRYGDVFRVHLGSVPVVVLSGLETIKRALVKN-GDAFAGRPPFYSLSLVGNGDTLTFTRAYDGCWKAHKRLARSALRNFCAAPARREGYACLLEECVCEEAERLLLACKGGGAQPGGFDPVPSITCAVA-NVMCALVFGKRYPHGDPTF---LQIVGFNEEASQLSGAGNLVDFFPF--LRHVPNAQLRALKVLSARLLAFMEGHIKEHYSS-YQKGHVRDITDALIAMCAEQEHALREVG----LSDERVVATALDIFGAGFDTIITGLTWCLLYLCIHPDVQHKLQREIDET-IGRDRTPRFEDRANLRRVEAFLTEMFRHSAFVPFTIPHSTTQDVVLNGMFIPRDTCVFVNLHQVNHDPTVWSDPERFDPDRFLSHDGKEVNKEMVEKVQIFGLGKRRCLGDMVARQE 484
BLAST of Cytochrome P450 2L1 vs. Ensembl Sea Lamprey
Match: cyp17a1 (cytochrome P450, family 17, subfamily A, polypeptide 1 [Source:ZFIN;Acc:ZDB-GENE-040213-2]) HSP 1 Score: 124.79 bits (312), Expect = 9.760e-31 Identity = 93/417 (22.30%), Postives = 185/417 (44.36%), Query Frame = 2
Query: 305 YGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLN-SVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTEISNNAYEL---FATHIREKKELVSDGGFYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNLAF--FDITP-LNCLPHPGKNKILEYSKYLSDKVQKHIKERKSDGNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKI 1534
YG + + G + V +++ + + +K S + AGRP + +++ G ++I A W R+ + L V + + A L +I ++ +D V C N++ V + + + + D + L+ G+ A D P L P+P ++ + + V + I K+ + + D+ ++ + + ++E + ILT+ + +D + AG++ W + L HP+VQD I +E+++ ++ + DKL YL+A + E++R+ ++ HRA+ D VG + I K + + N++ AH D +W NP+ F P RF+ + ++P +PFG G+R C+ E K F+F G + + ++
Sbjct: 75 YGAVYCLRVGGEDIVVLNNVESIKEMLIKK-SADFAGRPQTYAGGKITGGGKDIALG-DYSAVWRRQRRAALSALHCVGTARTEEIVQGEAQRLVEDLTQYIGRPTDIHTDISMRV---C-----NVICSVAFGTKYDKHDTEFLDIHCCLDSLVRLWGSPAIRALDCFPVLRLFPNPAWRDLMAAVRKRDEVVWRQILLHKAKPSSSPSSD-MTDFLLKFTRHSRNEEESEARGGILTEERVHLSIMDTFIAGVETTATLIEWALAYLVLHPEVQDQIYEEMEQK-LQPGLGPSLADRDKLLYLDATIKEILRLCPVAPLAIPHRALRDSSVGGFFICKGSTVIANLWAAHRDHAHWDNPSVFQPGRFLGESLERRNPASLLLPFGAGKRVCLGESLA-KAEIFLFLGHVLRRLRL 478
BLAST of Cytochrome P450 2L1 vs. Ensembl Sea Lamprey
Match: cyp2u1 (cytochrome P450, family 2, subfamily U, polypeptide 1 [Source:ZFIN;Acc:ZDB-GENE-070730-1]) HSP 1 Score: 112.464 bits (280), Expect = 8.466e-28 Identity = 79/303 (26.07%), Postives = 137/303 (45.21%), Query Frame = 2
Query: 734 ISVIGKLMAKVGNLAFFDITP-LNCLPHPGKNKILEYSKYLSDKVQKHIKERKSDGNYKVNPKYFID-YCIEIQDNQKEQKEKYGQLPILTDWFISNLSL-----DIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVK--VGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKITWSSKNKTDKVEED--LENTFFRHTAP 1609
+ V G +A + ++ P L CLP ++ +S ++K I + NP+ FID + +E + +E G+ P T + L D++ AG D W + L+ T+P VQ ++ EL + + +L A + EV R+ S+ H A V+ + + IP+ +++ LN++ H D + W P F+P+RF++ G+ + ++ FMPFG+GRR+C+ E E F+F + Q+F T S+ + D L+ TF AP
Sbjct: 1 LMVRGMELASICPAMLINVVPALRCLPCGPFRELFSTVDEVSRFLKKGIIREHEETLDPANPRDFIDAFLVESHGGHDDDEEGGGEAPGGTRGVLDADDLFYIVADLFIAGTDTTANTLLWCLLLMCTYPAVQARVQAELDAV-VGRGRRVSLSDRPRLPLTVATIMEVQRLSSVVPLAIPHSATRSVRTELRGFTIPRGSVVLLNLWACHVDPRVWARPLLFDPERFLDPHGRLRR-RDAFMPFGIGRRSCLGESLARVE-LFLFFSALMQEFTFTSSAPHSPDSAPRSPVLQGTFGLTYAP 300
BLAST of Cytochrome P450 2L1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000011204.1 (pep scaffold:Pmarinus_7.0:GL477378:78074:79555:1 gene:ENSPMAG00000010177.1 transcript:ENSPMAT00000011204.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 111.694 bits (278), Expect = 1.768e-26 Identity = 114/472 (24.15%), Postives = 198/472 (41.95%), Query Frame = 2
Query: 209 PGPKAWPIIGSIPDPYSSPLSYKRL---IEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVA--EPQKMTEISNNAYELFATHIREKKELVSDGGFYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGN--LAFFDITP-LNCLPHPGKNKILEYSKYLSDKVQKHIKERKSDGNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKITWSSKNKTDKVEEDLENTFFRH 1600
PGPK P++G+I + S K +++ +KYGE+ V VS Y+ + V + +E A RP+ + N I D W + R + LR + +IS A L T +E E D F + VG NI+ + +++N +Q ++ L+ + ++ P L LP P + K+ L ++ + E ++ + + NP+ ID + D +K+ + TD + L ++++ GM+ W + + +P +Q +E+ K + + K L YL+AV++E+ R ++ F H DV+ EY PK T + +N+ A YD +WK P++FNPD F++ DG+ + F+PF G C E K F+F + Q F+ W + + T H
Sbjct: 36 PGPKPLPLLGNI-----TAFSCKNPHIGMQELAKKYGEVCTIMLGSTPVVLVSGYQAVKEVLV-NRGHEFADRPITPLFTKLTHNIGIALAPYGDT-WKQQRGFALSTLRNFGFGKATITDKISIEARYLIETFKQETSEF--DPKFILNSA---VG-NIICSLLNGIRYDYNNEQFQKLTHLLEHLVQLQAEPLVILCNVFPFLIKLPGPWQ-KVFHIHTKLQCLLKDIVSEHRATKD-QHNPRDLIDSYLAHIDKEKDNPNRS-----FTDQTLILLLIELFIGGMETTSNTLCWGLLFMMMNPDIQARCHEEIDKV-VGSQRPPCMKDRRSLPYLDAVIHEIQRFGNILPFGVLHPTSKDVQFNEYVFPKGTHVMVNLMSAFYDDIHWKTPHKFNPDNFLDKDGQCIK-SDAFLPFPAGPCVCFGESL-AKMELFLFFTSLLQHFEFYWPNSASPPTLAAKFRTTLSPH 484
BLAST of Cytochrome P450 2L1 vs. Ensembl Yeast
Match: ERG5 (C-22 sterol desaturase; a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs [Source:SGD;Acc:S000004617]) HSP 1 Score: 67.3958 bits (163), Expect = 2.823e-12 Identity = 41/161 (25.47%), Postives = 72/161 (44.72%), Query Frame = 2
Query: 1010 ISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKE---LQKNDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTV 1483
IS FA DA W ++A P V IR+E ++ ND+ N +++K+ Y N V+ E +R + + Y PK ++ +Y A +D + ++NP+EF P+R++ K K+ ++ FG G C+ + Y +
Sbjct: 326 ISEAVFTFLFASQDASSSLACWLFQIVADRPDVLAKIREEQLAVRNNDMST--ELNLDLIEKMKYTNMVIKETLRYRPPVLMVPYVVKKNFPVSPNYTAPKGAMLIPTLYPALHDPEVYENPDEFIPERWVEG-SKASEAKKNWLVFGCGPHVCLGQTYVM 483
BLAST of Cytochrome P450 2L1 vs. Ensembl Yeast
Match: ERG11 (Lanosterol 14-alpha-demethylase; catalyzes C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in ergosterol biosynthesis pathway; transcriptionally down-regulated when ergosterol is in excess; member of cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p; human CYP51A1 functionally complements the lethality of the erg11 null mutation [Source:SGD;Acc:S000001049]) HSP 1 Score: 59.3066 bits (142), Expect = 9.805e-10 Identity = 44/180 (24.44%), Postives = 77/180 (42.78%), Query Frame = 2
Query: 995 LTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDKLHYLNAVVNEVMRI-HSLSSFTSFHRAMSDVKV--GEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRF-----------INADGKFQSPKEG----FMPFGVGRRTCVAERYT 1480
+TD I+NL + + G +W + LA P VQ + +E + + Y ++ ++ LN + E +R+ H L S F + M D+ V Y IP + ++ H +Y+ N ++FN R+ D F + +G ++PFG GR C+ E +
Sbjct: 299 MTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMHHPLHSL--FRKVMKDMHVPNTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNKDSASSYSVGEEVDYGFGAISKGVSSPYLPFGGGRHRCIGEHFA 476
BLAST of Cytochrome P450 2L1 vs. Ensembl Nematostella
Match: EDO40930 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S5T4]) HSP 1 Score: 157.918 bits (398), Expect = 3.553e-42 Identity = 120/458 (26.20%), Postives = 202/458 (44.10%), Query Frame = 2
Query: 200 NLPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLN-SVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTEISNNAYELFATHIREKKELVSDGGFYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNLAFFDITP-LNCLPHPGKNKILEYSK----YLSDKVQKHIKERKSDGNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQ------KNDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKIT 1537
NLPPGP+ +P+IG+ P S S + + + YG + G V V K + V + + +AGRP + ++D ++ G++NI F+ L+K+I + PQ +++N E+ A + + + F L V N++ + + D+P + + +I +G+++ D+ P L LP + +K Y +VQ+HI + Y I+ + +KE + + I+ + D+ G + W I LA +P+VQ + ++L KN + K D+L Y+ AV+ E MRI + H+A D + Y IPKDT + N++G H D W +P+ FNP RF++ DGKF E +PFG GRR C E+ K F+ T R+ + + T
Sbjct: 27 NLPPGPRPYPLIGNTPLLIGSFSSLHVKLTELAKIYGSVYTLYLNGQRSVIVCSAKAAREGLV-ERKDAIAGRPYSFTLDYVTNGSKNITFSDFCPTFL--LKKRIAQSSMRRYYPQVEDKVNNQLEEVLA-----RIKALDGTAFDPHHLLSLVTLNLVTSMTFGTNYTLDDPEFLLLVQMIDDSTRSIGSMSTLDMFPFLMHLPIRTSKLLKSITKTVNEYFMKQVQRHIDSNDGKSIRDLTDGY-------IKGLTEAEKEDASVHEVNSIEHIAMVMADMIVPGSETSSTTMGWMIAYLAVYPEVQARLHQQLDDVIGRDKNTV-----ITLKDRDRLPYVEAVIAETMRISTAVPLAIPHKATCDTTINGYFIPKDTTVIFNLWGVHLDPTEWADPHVFNPARFLDEDGKFIK-SEKLLPFGAGRRVCPGEK-IAKMQLFLMTSRLLRHLEFT 462
BLAST of Cytochrome P450 2L1 vs. Ensembl Nematostella
Match: EDO41284 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S507]) HSP 1 Score: 148.288 bits (373), Expect = 1.125e-38 Identity = 127/425 (29.88%), Postives = 212/425 (49.88%), Query Frame = 2
Query: 305 YGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLN-SVDRLSVGNENIFFTR-SLDAGWTELRKQIMIMLRKVAEPQKMTEISNNAYELFATHIREKKELVSDGG--FYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTI--SVIGKLMAKVGNLAFFDITP-LNCLPHPGKN---KILEYSKYLSDKVQKHIKERKSDGNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMM-DK--LHYLNAVVNEVMRIHSLSSFTSFHRAMSD-VKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSP-KEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKI 1534
YG+I K FV+VS + + N+LAGRP + + L+ G ++I F S W R++I+ ++ P K+ E N A+E+ + +++L+ D G + + NI+ + E D+P++ T+ + IG + G++ D P L LP K++E L DK K S+ + F+ +E++ +E K+ G++ TD I+ L D+YFAG++ SW L +PQVQ + + DI++V + ++ DK L Y+ A + EV+RI +++ H+A ++ V + Y+IPKDTII +N++ H+D + W NP++F+PDRFIN DGKF+ P + ++PF GRR CV E E + T R+ Q F +
Sbjct: 60 YGDIFTLKIFNDRFVFVSSGAGAREVLMGKRMNDLAGRPQTFTFNFLTRGAKDIIFGDYSRHLVW---RRKIVHSGLRMYFP-KLEE--NIAWEV----SKLERKLMKDVGTALHSRDEFSLLITNIISSFLLGKSFEPDDPDFLTTLEFTRIGSQLPVSGSI--LDNFPFLVHLPISESRFYKKLVEIRDRLLDKFFLEHKSTFSEDCIRDLTDAFLKAKLEVE---REDKKAIGEV---TDDHITMLMTDVYFAGLETTSTTLSWLAAYLINYPQVQTRL-----QTDIDDVIGSRWPVLADKPNLPYMEATIAEVLRIATVAPMGLPHKATTNNVPLMGYNIPKDTIIVMNLWAIHHDPREWPNPDKFDPDRFINEDGKFEVPGQRSYLPFSAGRRVCVGESLAKIELFLVMT-RLLQQFTL 460
BLAST of Cytochrome P450 2L1 vs. Ensembl Nematostella
Match: EDO30239 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T1C7]) HSP 1 Score: 146.747 bits (369), Expect = 2.415e-38 Identity = 119/454 (26.21%), Postives = 214/454 (47.14%), Query Frame = 2
Query: 203 LPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLN-SVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTEISNNAYELFATHIREKKELVSDGGFYVEQL--CYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVG-NLAFFDITP-LNCLP-HPGKN--KILEYSKYLSDKVQKHIKERKSDGNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDK---LHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKE-GFMPFGVGRRTCVAERYTVKESHFIFTGRICQDF 1528
+PPGP P+IG++ SS + ++ + + + +G+I++ + GM V V+ L + + + N+ AGRP + + +S G ++I G RK + LRK P I+ +L + +L SD G V+ + + NI+ A + ++P + +T+ ++ K + + + + D P L P KN +I E L + KE ++ + + F+ ++I+ +E K+ G++ TD ++ + +D+Y AG++ W I L + +VQ ++ I++V +M L Y+ A+V EV+R+ H+++ D + Y IPK T + N++ H+D + W P++F+PDRFIN DGKF+ P + F+PF GRR C+ E E I T R+ Q F
Sbjct: 1 MPPGPTPLPLIGNLLSIKSSNIHFE--LANLAKTHGDIMMIELFGMKIVVVTSGPLAREVLMGKHINDFAGRPKRFTFEYMSKGYKDIALN-DYSPGLVWKRKIVHSGLRKYF-PSLGDTIAKELAKL-------EDKLNSDVGVPVDSKDEFFLLVLNIICSFLSGKAFDKEDPEFSETLELVTKTVDTLSMSASILDAFPFLIHFPLQASKNFKRIAELRDKLMGNILTFHKETFNENHIRDLTDAFLKAKLDIE---REDKKAAGEV---TDEEVALMMMDVYLAGLETTVTSLRWIIAYLMNNQEVQSRVQSR-----IDDVIGDRRPLMSDRQGLPYMEALVAEVLRLSPPIPLGLPHKSILDTTIDGYTIPKGTTVLFNLWAIHHDPREWPEPDKFDPDRFINEDGKFEVPGDRNFLPFMAGRRVCLGESLAKMELFLIMT-RLLQQF 431
BLAST of Cytochrome P450 2L1 vs. Ensembl Nematostella
Match: EDO30875 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SZJ0]) HSP 1 Score: 144.05 bits (362), Expect = 2.117e-37 Identity = 117/454 (25.77%), Postives = 210/454 (46.26%), Query Frame = 2
Query: 203 LPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLN-SVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTEISNNAYELFATHIREKKELVSDGGFYVEQL--CYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVG-NLAFFDITP-LNCLP-HPGKN--KILEYSKYLSDKVQKHIKERKSDGNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDK---LHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKE-GFMPFGVGRRTCVAERYTVKESHFIFTGRICQDF 1528
+PPGP P+IG++ SS + ++ + + + +G+I++ + GM V V+ L + + + N+ AGRP + + +S G ++I G RK + LRK P I+ +L + +L SD G V+ + + NI+ A + ++P + +T+ + + + + + D P L P KN +I E L + KE ++ + + F+ ++I+ K+ E+ +TD ++ + +D+Y AG++ W I L + +VQ ++ I++V +M L Y+ A+V EV+R+ H+++ D + Y IPK T + N++ H+D + W P++F+PDRFIN DGKF+ P + F+PF GRR C+ E E I T R+ Q F
Sbjct: 1 MPPGPTPLPLIGNLLSIKSSNIHFE--LANLAKTHGDIMMIELFGMKIVVVTSGPLAREVLMGKHINDFAGRPKRFTFEYMSKGYKDIALN-DYSPGLVWKRKIVHSGLRKYF-PSLGDTIAKELAKL-------EDKLNSDVGVPVDSKDEFFLLVLNIICSFLTGKAFDKEDPEFSETLEFVTMTVDTISMSASILDAFPFLIHFPLQASKNFKRIAELRDKLMGNILTFHKETFNENHIRDLTDAFLKAKLDIEREDKKAAEE------VTDEEVALMMMDVYLAGLETTVTSLRWIIAYLMNNQEVQSRVQSR-----IDDVIGDRRPLMSDRQGLPYMEALVAEVLRLSPPIPLGLPHKSILDTTIDGYTIPKGTTVLFNLWAIHHDPREWPEPDKFDPDRFINEDGKFEVPGDRNFLPFMAGRRVCLGESLAKMELFLIMT-RLLQQF 431
BLAST of Cytochrome P450 2L1 vs. Ensembl Nematostella
Match: EDO28446 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T6F9]) HSP 1 Score: 142.51 bits (358), Expect = 7.057e-37 Identity = 123/427 (28.81%), Postives = 211/427 (49.41%), Query Frame = 2
Query: 299 EKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLN-SVDRLSVGNENIF---FTRSLDAGWTELRKQIMIMLRKVAEPQKMTEISNNAYELFATHIREKKELVSDGG--FYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNLAFFDITP-LNCLPHPGKN---KILEYSKYLSDKVQKHIKERKSDGNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMM-DK--LHYLNAVVNEVMRIHSLSSFTSFHRAMSD-VKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSP-KEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKI 1534
+ YG+I + K FV+VS + + N+LAGRP + + LS G ++I ++R L W R++I+ + ++ P K+ E N A+E+ + + +L+ D G + +++ + NI+ + E D+P++ T+ I K + + D P L LP ++E L DK K S+ + F+ +E++ +E K+ G++ TD I+ L D+Y G++ SW L +P VQ + + DI++V + ++ DK L Y+ A + EV+RI ++ H+A ++ V + Y+IPKDTII +N++ H+D + W NP++F+PDRFIN DGKF+ P + ++PF GRR CV E E + T R+ Q F +
Sbjct: 24 KTYGDIFMLKIFNDRFVFVSSGAGAREVLMGKRMNDLAGRPQTFTFNLLSRGAKDIVLGDYSRHL--VW---RRKIVHLGLRMYFP-KLEE--NIAWEVS----KLEGKLMEDIGAAIHSKEVFLLLITNIISSFLLGKSYEPDDPDFLTTLEFIRKGSQVPVSGSILDKFPFLYHLPISESRFYKNVVEPRDRLLDKFFLEHKSTFSEDCIRDLTDAFLKAKLEVE---REDKKAIGEV---TDDHITMLMTDVYVGGLETTSTTLSWLAAYLINYPLVQTRL-----QTDIDDVIGSRWPVLADKPNLPYMEATIAEVLRIATVLPMGVPHKATTNNVPLMGYNIPKDTIIVMNLWAIHHDPREWPNPDKFDPDRFINEDGKFEVPGQRSYLPFSAGRRVCVGESLAKIELFLVMT-RLLQQFTL 426
BLAST of Cytochrome P450 2L1 vs. Ensembl Medaka
Match: cyp2n13 (cytochrome P450 2J6 [Source:NCBI gene;Acc:101156965]) HSP 1 Score: 143.28 bits (360), Expect = 1.507e-36 Identity = 129/464 (27.80%), Postives = 206/464 (44.40%), Query Frame = 2
Query: 191 KKHNLPPGPKAWPIIGSI-------PDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLNSVD-RLSVGNEN-IFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTEISNNAYELFATHIREKKELVSDGGFYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNL--AFFDITPLNCLPHPGK-NKILEYSKYLSDKVQKHIKERKSDGNYKVNPKYFID-YCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDK--LHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKIT 1537
K N PPGP P +G+ P Y S ++ E YG + + V+VS YK+ +A V N RP + + R GN N +FF+ W + R+ + LR + E S E+ H++++ E G F L NI+ Q+ ++D+ N+Q + I + + G++ ++ P PG NKI K + D + + IK K D + NP+ +ID + IE++ K Q G D ++ SLD++ AG + W + L HP VQ +++E+ + +N M D+ L Y +AVV+E+ RI ++ A D +G Y IPK T + + +D W+ P+ FNP+ F++ADGKF KE F+PF G+R C+ E E F+F + Q F +
Sbjct: 33 KPANFPPGPLGLPFVGNFLTIDGKHPHIYFSKMA---------ESYGNVFSVRLGSQATVFVSGYKMVKEALVTQAEN-FVDRPFSEIGGRFYEGNSNGLFFSNG--EKWKKQRRFALSTLRTFGLGKNTMEQSI-CEEI--RHLQQQIENEKGGPFSPAGLFNNAVSNIICQLVMGKRFDYDDNNFQVMMKYISEAVQLEGSIWGILYESFPGLMKHLPGSHNKIFRNYKIVQDFLAQEIKIHKQDLDPN-NPRDYIDSFIIEME---KHQNSDLG----FNDANLAFCSLDLFVAGTETTSTTLMWALIYLIKHPDVQVKVQQEIDRVIGQNRLP---SMADRPNLPYTDAVVHEIQRIGNIVPLNGLRVAAKDTTLGGYFIPKGTALMPMLTSVLFDKTEWETPDTFNPEHFLDADGKFVK-KEAFLPFSAGKRVCLGEGLARMEL-FLFLVGLLQKFSFS 468
BLAST of Cytochrome P450 2L1 vs. Ensembl Medaka
Match: ENSORLT00000017336.2 (pep primary_assembly:ASM223467v1:6:26186654:26196090:-1 gene:ENSORLG00000013826.2 transcript:ENSORLT00000017336.2 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 141.354 bits (355), Expect = 6.594e-36 Identity = 137/496 (27.62%), Postives = 224/496 (45.16%), Query Frame = 2
Query: 128 SSVFYLCLGIVAYIIYKWHFPKKHNLPPGPKAWPIIG-----SIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRP----LNSV-DRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTEISNNAYELFATHIREKKELVSDGGFYVEQLCYW-VGHNILVQVFWEDAVEFDNPNYQDTISVIGKLM---AKVGN---LAFFDITP-LNCLPHPGKN--KILEYSKYLSDKVQKHIKERKSDGNYKVNPKYFID-YCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFG----IGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKITW 1540
+S+ L L ++ +++Y + N PPGP P++G S DP E ++ YG + V ++ K +A V S+ AGRP +N V +L V EN T W E R+ ++ LR + T + + +E I+ ++ S G Q+ + NI+ QV + E+++ + I VI K AK+ N +D P L LP P + K E K ++ + K KE K G P+ F+D Y E++ + ++ ++ SLD+YFAG D GF + +G HP +Q+ ++E+ +E + +++ + + Y+ AV++EV RI ++ F+ FH M D ++ EY IPK T++ N+ + WK P+EFNP+ F+N G+F P E FMPF G R C+ E E F+ + + FK TW
Sbjct: 3 ASLVLLGL-LIFFLVYLLKPQRPKNFPPGPPTLPVLGNLLHLSTDDPLKD-------FERLRKSYGNVFSVFIGPQPAVVINGLKAMKEALVNKGSD-FAGRPQDLFINHVTQQLGVVLENYGTT------WREHRRFALMTLRNFGLGK--TSMEDRIHEEIQQTIKTLEK--SIGSTLSPQVIFHNAASNIICQVLYGKRFEYND----EMIKVIIKCFTDNAKMTNGPWAMIYDSLPILRKLPLPFRKAFKNYETCKNIAFDLLKEHKETKVPGE----PRDFVDCYLDELEKKSADSS--------FSEERLAGYSLDLYFAGTDTTSNTLLTGFLYLVG----HPHIQERCQQEIDLV-LEGKDQVSFEDRNNMPYMQAVIHEVQRIANIVPFSVFHATMKDTELMEYSIPKGTMVIQNMKSVLTEEGQWKFPHEFNPENFLNEKGEFVKP-EAFMPFSAGPRVCLGEGLARMEL-FLTMVTLLRKFKFTW 456
BLAST of Cytochrome P450 2L1 vs. Ensembl Medaka
Match: ENSORLT00000018724.2 (cytochrome P450 2J1 [Source:NCBI gene;Acc:105353996]) HSP 1 Score: 132.88 bits (333), Expect = 7.348e-33 Identity = 109/450 (24.22%), Postives = 202/450 (44.89%), Query Frame = 2
Query: 191 KKHNLPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTE--ISNNAYELFATHIREKKELVSDGGFYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNLA--FFDITP--LNCLPHPGKNKILEYSKYLSDKVQKHIKERKSDGNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLPILTDWFISNL---SLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDK--LHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFT 1507
+ N PPGP + P IG + + L + ++ EKYG + +G V ++ YK +A V+ ++ RP + ++ N+ I + W + R+ + LR +K E I N + + T +K+ D F + NI+ + + + E+ + YQ + + L+ G+++ +++ P + LP P + KI ++ + D V+ I E K + + Y + IE++ +Q + + + I N+ ++D++ AG + W + + +P +Q+ + E+ D S M DK + Y +AV++E+ R+ + F +A D + +Y IPK TII ++ +D W NP+ F+P F++ DGKF +E F PFG G+R C+ E+ E FT
Sbjct: 36 RPKNFPPGPHSLPFIGDLHRIQPARLHVQ--FTEFAEKYGNVFSLHLLGERTVILNGYKQVKEALVQQ-GDDFVDRPTIPLFVDTIDNKGIVMSNG--NSWKQQRRFALHTLRNFGLGKKTMETYIQNECHYITQT-FADKQGKPFDAQFLINNAV----SNIICCLVFGERFEYSDQEYQKILRNLNDLLILEGSVSAMLYNMFPWLMKRLPGPHQ-KIFSLTRKIIDFVKIKINEHKGNFDPSAPEDYIDSFLIEMEKSQDKD----------SGFDIDNMCICTMDLFLAGTETTTTTLYWGLLYMIYYPDIQEKVHAEI---DAVIGSSRQPSMADKESMPYTDAVIHEIQRMGDIVPQGVFRQANRDTTLDKYTIPKGTIIVPALHSVLHDESMWDNPHSFDPKNFLDKDGKF-CKREAFNPFGAGKRVCLGEQLARMELFLFFT 460
BLAST of Cytochrome P450 2L1 vs. Ensembl Medaka
Match: cyp2n13 (cytochrome P450 2J2 [Source:NCBI gene;Acc:101160974]) HSP 1 Score: 130.568 bits (327), Expect = 5.294e-32 Identity = 115/450 (25.56%), Postives = 199/450 (44.22%), Query Frame = 2
Query: 221 AWPIIGSIPDPYS-SPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLNS-VDRLSVGNE-NIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTEISNNAYELFATHIREKKELVSDGGFYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNL--AFFDITP--LNCLPHPGKNKILEYSKYLSDKVQKHIKERKSDGNYKVNPKYFID-YCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKITWSS 1546
A P++G+I S P Y + D YG + + V+V+ +K +A V N RP + V R+ GN +FF+ + W R+ M MLR + TE S + H+ E E+ F L NI+ Q+ + ++ + ++Q ++ + + G++ +D P + LP P N I SK L +++ I K D + NP+ +ID + +E + N+K + +L LD++ AG + W + L T+P +QD ++ E+ + + + + Y +AV++E+ R+ ++ A D +G Y IPK T + N+ +D W+ P+ FNP+ F++ADGK KE F+PF GRR C+ E E F+F + Q F + ++
Sbjct: 64 ALPVLGNIFSIDSKQPHIYLTKLAD---VYGNVFCIRLGRHKTVFVTGWKTVKEALVTQADN-FVDRPYSPMVTRIYGGNSAGLFFSNG--SVWKRQRRFAMTMLRTFGAAKSSTEQSICEE---SRHLLEAMEMEGGEPFDPVPLLNKAVSNIICQIVFGRRFDYSDTDFQAMLTNLTDMAYLEGSVWALLYDAFPALMKYLPGP-HNSIFSSSKSLETTIRREINRHKQDLD-PSNPRDYIDKFLMEERHNRKIHSGFEEENLVLC-------CLDLFLAGSETTSKTLQWGLIYLITNPHIQDKVQAEMDRV-VGHSRQPTTADRTNMPYTDAVIHEIQRMGNIVPLNGLRMAAKDTTLGGYIIPKGTAVMPNLTSVLFDKTEWETPDNFNPEHFLDADGKLLR-KEAFLPFSAGRRACLGEGLARMEL-FLFFVTLFQRFHFSAAA 492
BLAST of Cytochrome P450 2L1 vs. Ensembl Medaka
Match: cyp21a2 (steroid 21-hydroxylase [Source:NCBI gene;Acc:101157155]) HSP 1 Score: 130.183 bits (326), Expect = 7.236e-32 Identity = 110/454 (24.23%), Postives = 202/454 (44.49%), Query Frame = 2
Query: 209 PGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLN-SVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTEISNNAYELFATHIREKKELVSDGGFYVE--QLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGN--LAFFDITPL-NCLPHPGKNKILEYSKYLSDKVQKHIKERKSDGNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKITWSSKN 1552
PGP +IG++ + L + ++YG I K V ++ +L + V+ +S+ AGRP++ + D +S G NI + W R+ + L++ + + I A L +K L+ G V+ + N++ + + + + Q S + ++++ G+ ++ D PL LP+P ++L+ + +++H+ K G+ + I + +Q K Q K GQL LTD + ++D+ G + +WT+ L P++QD + +EL + Y +L L A+VNEV+R+ ++ HRA+ + + + IPK+++I N++GAH+D W P F P+RF+ G +PFG G R C+ E K F+FT + +DF+ N
Sbjct: 58 PGPPGHFLIGNMMELMHDHLPIH--LTSLAQRYGSIYRLKCGNTTMVVLNSGELIRETLVRKWSD-FAGRPISYTGDIVSGGGRNISLGDYTEE-WRAHRRLVHGALQRCCQQSLHSVIERQALHL-------RKVLMGYQGSPVDLSEDFTVAASNVITTLAFGKEYDKSSSELQQLHSCLNEIVSLWGSSWISALDSFPLLRKLPNPVFARLLKEVARRDEIIKQHLDNFKLQGHQSEDS---ITGSL-LQALDKHQNTKEGQL--LTDVHVHMATVDLLIGGTETTAAWLNWTVAFLLHRPEIQDKVYEEL--CTVPEGRYPKYSDRQRLPVLCALVNEVLRLRPVAPLAVPHRAIRNSSIAGFFIPKNSVIIPNLFGAHHDPAVWSEPYSFKPERFLEGGG---GSTRALVPFGGGARLCLGES-VAKMELFLFTAYLLRDFQFILPESN 488
BLAST of Cytochrome P450 2L1 vs. Planmine SMEST
Match: SMESG000050434.1 (SMESG000050434.1) HSP 1 Score: 1053.12 bits (2722), Expect = 0.000e+0 Identity = 505/510 (99.02%), Postives = 507/510 (99.41%), Query Frame = 2
Query: 107 MLTDLFESSVFYLCLGIVAYIIYKWHFPKKHNLPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTEISNNAYELFATHIREKKELVSDGGFYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNLAFFDITPLNCLPHPGKNKILEYSKYLSDKVQKHIKERKSDGNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKITWSSKNKTDKVEEDLENTFFRHTAPFYVEFHPIK 1636
MLTDLFESSVFYLCLGIVAYIIYKWHFPKKHNLPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFK+MGMNFVYVSDYKLGYQAFVKDYSNELAGRPLNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTEISNNAYELFATHIREKKELVSDGGFYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNLAFFDITPLNCLPHPGKNKILEYSKYLSDKVQKHIKERKSDGNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLP+LTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHP VQDNIRKELQKNDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYD KYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKITWSSKNKTDKVEEDLENTFFRHTAPFYVEFH IK
Sbjct: 1 MLTDLFESSVFYLCLGIVAYIIYKWHFPKKHNLPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKRMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTEISNNAYELFATHIREKKELVSDGGFYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVGNLAFFDITPLNCLPHPGKNKILEYSKYLSDKVQKHIKERKSDGNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLPMLTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPHVQDNIRKELQKNDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDPKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKITWSSKNKTDKVEEDLENTFFRHTAPFYVEFHSIK 510
BLAST of Cytochrome P450 2L1 vs. Planmine SMEST
Match: SMESG000080703.1 (SMESG000080703.1) HSP 1 Score: 223.016 bits (567), Expect = 5.330e-66 Identity = 144/495 (29.09%), Postives = 246/495 (49.70%), Query Frame = 2
Query: 197 HNLPPGP-----KAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTEISNNAYELFATHIREKKELVSDGGFYVEQLCYWVGHNILVQVFWEDAV-EFDNPNYQDTISVIGKLMAKVGNLAFFDITPLNCLPHPGKNKILEYSKYLSDKVQKHIKERKSDGNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLPI-------LTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQK-NDIENVE-SFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKITWSSKNKTDKVEEDLENTFFRHTAPFYVEFHPIK 1636
+ LPPGP +A II + L Y+++++ + KYG I + G V+++D + GY+ FV+ S +++GR + +++ GN N W L++ + LR A ++ EI ++ F + E + +GG V+ +W+ N++ + + + + D YQ I VI + + F + P K+ + L + +Q I E + G+YK+ C +I D E+Y P LTD + + +D+ FA + G F W GLLA +P +Q+NIR E+ K D NVE + ++K K+ Y NAV+ E+ R S +FT FH M D+ +G Y+IPKD++I LN+Y H+D K WKNP+ +P F++ DG+ ++ F+P+G+G RTCV ++ + F+ + ++K+ W KNK+ ++ +D F R PF ++F +K
Sbjct: 8 YKLPPGPNRNSDEADFII-------NEKLIYQKIVQKYIPKYGPICTLYKDGTPVVFINDIETGYEVFVRKLSKQVSGRSASYGEKILSGNRNNILNSDYGPLWKTLQRNLHKGLRHCANLDRLNEIMYKCFDKFKETV-EYRRGSKNGGIEVDNDLFWMADNVITMLLFNEIFNDVDYKKYQGAIEVIPQYAEECD---FPNDKPSKKSDFKSVEKLQKVFNQLIEVLQIRIDEHRKKGDYKI-------ACFDITDFVLLAVEEYHLDPKSKKLGIKLTDLHVKHSLIDVIFASQEGLGNSFVWVFGLLALYPNIQENIRTEINKFRDDNNVEVTLHWK--SKMPYTNAVLCEIQRYASADTFTDFHSTMDDINIGPYEIPKDSLIVLNLYAIHHDKKQWKNPDIIDPQNFLSEDGRSFKRRKDFVPYGLGLRTCVGNTFS-ENVLFVLIMLVVDNYKMVW-GKNKSQEIIDDKNAVFIRDVEPFNIQFIRLK 480
BLAST of Cytochrome P450 2L1 vs. Planmine SMEST
Match: SMESG000012534.1 (SMESG000012534.1) HSP 1 Score: 171.785 bits (434), Expect = 3.096e-47 Identity = 126/453 (27.81%), Postives = 217/453 (47.90%), Query Frame = 2
Query: 272 YKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGR-PLNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTEISNNAYELFATHIREKKELVSDGGFYVEQLCYWVGHNILVQVFWEDAVEFDNPNY---QDTISVIGKLMAK---VGNLAFFDITPLNCLPHPGKNKILEYSKYLSDKVQKHIKERKSDGNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQK---NDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKITWSSKNKTDKVEEDLENT-FFR 1597
YKR++E +K KYG ++ V+++DYKL +A LAGR + + D +S NIF + W E+ + + + + K + + + + + + G F ++ YW+ N ++ + ++ +Y QD+ + +M K V + F PL C+ ++ E S L++ + K + + + G Y+ NP I+Y ++ +N K EK L D I + DI FA + G+ W + LL HPQ+Q+ IR ++ K ++ F +K ++L Y+ AV E R S+ FH A+ V +G Y IPK +IA+N Y ++D++ W+NP P+RF+++ G F + + MPFG+G R C T K F+ +C ++KI WSS+N+ ++ +D EN FR
Sbjct: 3 YKRMVEYYKPKYGNLVTLFWGNTPIVFINDYKLAIEALGNKNGKHLAGRKSVQTEDIVSEERHNIF-GNNYGPLWKEMIRALKLGVSKCGLTPSLEKNIQKSINFYCDELIRNPDNSGKGVFPFDE-SYWLSDNTVLSIVIGRTFTLEDEDYIILQDSRRQVFDIMDKSEFVNWIPFGRYLPLKCI-----RRLFEQSTKLNNLLAKFVSDARKMGRYRNNPDNIIEYLLQETENSKLVTEKKVNL---NDVHIRQIFKDILFASYEGIGMTNIWYMALLGLHPQIQERIRLDITKLCSKKKDSTPKFEWK--NELPYIQAVEYEFFRFSSIVGILDFHCALKSVTLGGYHIPKGCLIAVNQYAINHDAERWENPETIKPERFLDSSGAF-TDRSDLMPFGMGVRMCPGTSIT-KGYGFLLLCNLCLNYKIKWSSENEFTELVDDPENAVLFR 441
BLAST of Cytochrome P450 2L1 vs. Planmine SMEST
Match: SMESG000012534.1 (SMESG000012534.1) HSP 1 Score: 165.622 bits (418), Expect = 5.382e-45 Identity = 123/450 (27.33%), Postives = 214/450 (47.56%), Query Frame = 2
Query: 281 LIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGR-PLNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVAEPQKMTEISNNAYELFATHIREKKELVSDGGFYVEQLCYWVGHNILVQVFWEDAVEFDNPNY---QDTISVIGKLMAK---VGNLAFFDITPLNCLPHPGKNKILEYSKYLSDKVQKHIKERKSDGNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQK---NDIENVESFNYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQSPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKITWSSKNKTDKVEEDLENT-FFR 1597
++E +K KYG ++ V+++DYKL +A LAGR + + D +S NIF + W E+ + + + + K + + + + + + G F ++ YW+ N ++ + ++ +Y QD+ + +M K V + F PL C+ ++ E S L++ + K + + + G Y+ NP I+Y ++ +N K EK L D I + DI FA + G+ W + LL HPQ+Q+ IR ++ K ++ F +K ++L Y+ AV E R S+ FH A+ V +G Y IPK +IA+N Y ++D++ W+NP P+RF+++ G F + + MPFG+G R C T K F+ +C ++KI WSS+N+ ++ +D EN FR
Sbjct: 1 MVEYYKPKYGNLVTLFWGNTPIVFINDYKLAIEALGNKNGKHLAGRKSVQTEDIVSEERHNIF-GNNYGPLWKEMIRALKLGVSKCGLTPSLEKNIQKSINFYCDELIRNPDNSGKGVFPFDE-SYWLSDNTVLSIVIGRTFTLEDEDYIILQDSRRQVFDIMDKSEFVNWIPFGRYLPLKCI-----RRLFEQSTKLNNLLAKFVSDARKMGRYRNNPDNIIEYLLQETENSKLVTEKKVNL---NDVHIRQIFKDILFASYEGIGMTNIWYMALLGLHPQIQERIRLDITKLCSKKKDSTPKFEWK--NELPYIQAVEYEFFRFSSIVGILDFHCALKSVTLGGYHIPKGCLIAVNQYAINHDAERWENPETIKPERFLDSSGAF-TDRSDLMPFGMGVRMCPGTSIT-KGYGFLLLCNLCLNYKIKWSSENEFTELVDDPENAVLFR 436
BLAST of Cytochrome P450 2L1 vs. Planmine SMEST
Match: SMESG000020470.1 (SMESG000020470.1) HSP 1 Score: 155.606 bits (392), Expect = 6.763e-41 Identity = 130/492 (26.42%), Postives = 229/492 (46.54%), Query Frame = 2
Query: 134 VFYLCLGIVAYIIYKWHF----PKKHNLPPGPKAWPIIGSIPDPYSSPLSYKRLIEDWKEKYGEIILFKQMGMNFVYVSDYKLGYQAFVKDYSNELAGRPLNSVDRLSVGNENIFFTRSLDAGWTELRKQIMIMLRKVA-EPQKMTEISNNAYELFATHIREK-KELVSDGGFYVEQLCYWVGHNILVQVFWEDAVEFDNPNYQDTISVIGKLMAKVG-NLAFFDITP-LNCLPH--------PGKNKILEYSKYLSDKVQKHIKERKSDGNYKVNPKYFIDYCIEIQDNQKEQKEKYGQLPILTDWFISNLSLDIYFAGMDAFGIGFSWTIGLLATHPQVQDNIRKELQKNDIENVESF-NYKMMDKLHYLNAVVNEVMRIHSLSSFTSFHRAMSDVKVGEYDIPKDTIIALNIYGAHYDSKYWKNPNEFNPDRFINADGKFQ---SPKEGFMPFGVGRRTCVAERYTVKESHFIFTGRICQDFKITWSSK 1549
+ ++ LGI Y I K+ F K NL GP WP+IG+I + ++ PL ++ + + YG + + + V +S K+ ++ +K+ N +GR N + + N I FT W R + +LR Q+ EI +N + I E+ ++VS + + N++ ++ E D+ ++ + +I K + L F + P L+ +P G+NK +K S + I + K N + + FID ++ Q E+K K TD + + L+++FAG + SW++ LLA HP +Q+ + +E+ D+ E N+ L Y AV++E++R+ ++ + HR + +V IPKD+II N++ H D W+ P EF P+ F+N + Q +P++ +PF +G+R C+ E E FIF I Q FKI + ++
Sbjct: 6 LIFITLGIALYFIKKFFFNQSASKNLNLLQGPTGWPLIGNI-NSFNEPLWM--VLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKT-LKEQGNNFSGRFQNFLIKARTRNSGILFTEK--EWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATV-----NVIAKLVMNMRFESDSKDFTELTKLIEKAIQNNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKT---AKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTF---TDQQLIRVVLELFFAGYETTSTTLSWSMLLLAKHPNIQEKVYQEIV--DLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIE-FFIFLTGIIQKFKIRFENE 477 The following BLAST results are available for this feature:
BLAST of Cytochrome P450 2L1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Cytochrome P450 2L1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Cytochrome P450 2L1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Cytochrome P450 2L1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Cytochrome P450 2L1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Cytochrome P450 2L1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Cytochrome P450 2L1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Cytochrome P450 2L1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Cytochrome P450 2L1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Cytochrome P450 2L1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Cytochrome P450 2L1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 2
BLAST of Cytochrome P450 2L1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Cytochrome P450 2L1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Cytochrome P450 2L1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30031568 ID=SMED30031568|Name=Cytochrome P450 2L1|organism=Schmidtea mediterranea sexual|type=transcript|length=1726bpback to top protein sequence of SMED30031568-orf-1 >SMED30031568-orf-1 ID=SMED30031568-orf-1|Name=SMED30031568-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=127bp LYTKCETYLLQILFNFNEQNNLIRKMLPNSFDWMKFYIKWRSMPEKCVFKback to top protein sequence of SMED30031568-orf-2 >SMED30031568-orf-2 ID=SMED30031568-orf-2|Name=SMED30031568-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=511bp MLTDLFESSVFYLCLGIVAYIIYKWHFPKKHNLPPGPKAWPIIGSIPDPYback to top Aliases
The feature 'Cytochrome P450 2L1' has the following synonyms
Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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