Metalloendopeptidase

Overview
NameMetalloendopeptidase
Smed IDSMED30031555
Length (bp)580
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Metalloendopeptidase (SMED30031555) t-SNE clustered cells

Violin plots show distribution of expression levels for Metalloendopeptidase (SMED30031555) in cells (dots) of each of the 12 neoblast clusters.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30031555

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 7

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
prepharyngeal regionSMED30031555h1SMcG0003813 SmedASXL_032689SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
parapharyngeal regionSMED30031555h1SMcG0003813 SmedASXL_032689SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
prepharyngeal regionSMED30031555h1SMcG0003813 SmedASXL_008757SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
parapharyngeal regionSMED30031555h1SMcG0003813 SmedASXL_008757SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
parapharyngeal regionSMED30031555h1SMcG0003813 dd_Smed_v6_11244_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
parapharyngeal regionSMED30031555h1SMcG0003813 dd_Smed_v6_12688_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
head regionSMED30031555h1SMcG0003813 OX_Smed_1.0.20035ox_Smed_v2PMID:24238224
Kao et al., 2013		whole organism asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Human
Match: ASTL (astacin like metalloendopeptidase [Source:HGNC Symbol;Acc:HGNC:31704])

HSP 1 Score: 84.3445 bits (207), Expect = 9.048e-19
Identity = 53/172 (30.81%), Postives = 88/172 (51.16%), Query Frame = 2 
Query:   98 DDMILSEKDILRINGFK--AAQAALWPDKTA-----RYIFDPSYPDRNKNRIREYLKIYEGELGNCLKF--YEDKSDVHATVIMGKGCSSSIGYDKNKELRITLPDVCVNKRN--VKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTSTPYDFDSIM 580
            +   L E DI+R + F+  +A +  WP   +      ++    Y + ++  I E L  +E     C++F  Y+D+ D  + + M  GC SS+G     ++ ++L   C+ K    V HE  H+LGF HEHTR DRD+Y+++    + P +  NF   +     TPYD+ S+M
Sbjct:   69 ESSFLIEGDIIRPSPFRLLSATSNKWPMGGSGVVEVPFLLSSKYDEPSRQVILEALAEFE--RSTCIRFVTYQDQRDFISIIPM-YGCFSSVGRSGGMQV-VSLAPTCLQKGRGIVLHELMHVLGFWHEHTRADRDRYIRVNWNEILPGFEINFIKSQSSNMLTPYDYSSVM 236
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Human
Match: TLL2 (tolloid like 2 [Source:HGNC Symbol;Acc:HGNC:11844])

HSP 1 Score: 79.7221 bits (195), Expect = 6.186e-17
Identity = 45/145 (31.03%), Postives = 73/145 (50.34%), Query Frame = 2 
Query:  164 LWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMGK---GCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTST---PYDFDSIM 580
            +WP     Y+   ++    +   ++ ++ +E     C+ F E ++D  + ++      GC S +G        I++   C     V HE  H++GF HEHTRPDRDQ++ I+ EN+ P   +NF   E  + S+    YDFDSIM
Sbjct:  158 IWPGGVIPYVIGGNFTGSQRAIFKQAMRHWEKH--TCVTFIE-RTDEESFIVFSYRTCGCCSYVGRRGGGPQAISIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIM 299
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Human
Match: TLL1 (tolloid like 1 [Source:HGNC Symbol;Acc:HGNC:11843])

HSP 1 Score: 78.5666 bits (192), Expect = 9.467e-17
Identity = 45/145 (31.03%), Postives = 73/145 (50.34%), Query Frame = 2 
Query:  164 LWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMGK---GCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTST---PYDFDSIM 580
            +WP     Y+   ++    +   ++ ++ +E     C+ F E +SD  + ++      GC S +G   N    I++   C     V HE  H++GF HEHTRPDRD ++ I+ EN+ P   +NF   E  + ++    YDFDSIM
Sbjct:  156 IWPGGVIPYVIGGNFTGSQRAMFKQAMRHWEKH--TCVTFIE-RSDEESYIVFTYRPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDNHVTIIRENIQPGQEYNFLKMEPGEVNSLGERYDFDSIM 297
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Human
Match: TLL1 (tolloid like 1 [Source:HGNC Symbol;Acc:HGNC:11843])

HSP 1 Score: 77.411 bits (189), Expect = 3.497e-16
Identity = 45/145 (31.03%), Postives = 73/145 (50.34%), Query Frame = 2 
Query:  164 LWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMGK---GCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTST---PYDFDSIM 580
            +WP     Y+   ++    +   ++ ++ +E     C+ F E +SD  + ++      GC S +G   N    I++   C     V HE  H++GF HEHTRPDRD ++ I+ EN+ P   +NF   E  + ++    YDFDSIM
Sbjct:  156 IWPGGVIPYVIGGNFTGSQRAMFKQAMRHWEKH--TCVTFIE-RSDEESYIVFTYRPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDNHVTIIRENIQPGQEYNFLKMEPGEVNSLGERYDFDSIM 297
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Human
Match: TLL1 (tolloid like 1 [Source:HGNC Symbol;Acc:HGNC:11843])

HSP 1 Score: 77.411 bits (189), Expect = 3.508e-16
Identity = 45/145 (31.03%), Postives = 73/145 (50.34%), Query Frame = 2 
Query:  164 LWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMGK---GCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTST---PYDFDSIM 580
            +WP     Y+   ++    +   ++ ++ +E     C+ F E +SD  + ++      GC S +G   N    I++   C     V HE  H++GF HEHTRPDRD ++ I+ EN+ P   +NF   E  + ++    YDFDSIM
Sbjct:  156 IWPGGVIPYVIGGNFTGSQRAMFKQAMRHWEKH--TCVTFIE-RSDEESYIVFTYRPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDNHVTIIRENIQPGQEYNFLKMEPGEVNSLGERYDFDSIM 297
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Celegans
Match: nas-27 (Zinc metalloproteinase nas-27 [Source:UniProtKB/Swiss-Prot;Acc:O17264])

HSP 1 Score: 72.0182 bits (175), Expect = 7.939e-15
Identity = 38/110 (34.55%), Postives = 62/110 (56.36%), Query Frame = 2 
Query:  188 YIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDV-HATVIMGKGCSSSIGYDKN-KELRITLPDVCVNKR-NVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSP 508
            Y FD ++P R++ R+ E ++ +  +   C+ F+E++    H ++  G GC S +G   + +E  ++L   C +    V HE  H LGF HEH R DRDQ++ I   NV+P
Sbjct:   73 YSFDRNFPSRSRQRVLEAMQFWSEK--TCVTFHENRYVYPHVSIFEGNGCWSFVGKQPSLREQSLSLERSCTDHTFVVAHEIAHTLGFYHEHARGDRDQFISIDYSNVNP 180
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Celegans
Match: nas-7 (Zinc metalloproteinase nas-7 [Source:UniProtKB/Swiss-Prot;Acc:P55113])

HSP 1 Score: 71.633 bits (174), Expect = 8.758e-15
Identity = 45/153 (29.41%), Postives = 75/153 (49.02%), Query Frame = 2 
Query:  137 NGFKAAQAALWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMGK--GCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTS---TPYDFDSIM 580
            NG   A A LWP+    Y   P Y    +  + + +K Y  +   C++F   ++     + +GK  GC S +G     ++ ++L + C+    + HE  H++GF HEH R DRD ++ I+ +N+       F   +  KTS    PYD+ SI+
Sbjct:   80 NGVSRA-AKLWPNARIPYAISPHYSPHERALLAKAVKQYHEK--TCIRFVPRQTGEPDYLFIGKVDGCFSEVGRTSGVQV-LSLDNGCMEYATIIHEMMHVVGFYHEHERWDRDNFIDIIWQNIDRGALDQFGKVDLSKTSYYGQPYDYKSIL 228
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Celegans
Match: nas-18 (Zinc metalloproteinase nas-18 [Source:UniProtKB/Swiss-Prot;Acc:Q21179])

HSP 1 Score: 70.0922 bits (170), Expect = 9.717e-15
Identity = 39/104 (37.50%), Postives = 55/104 (52.88%), Query Frame = 2 
Query:  272 CLKFYEDKSDVH-ATVIMGKGCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTSTPYDFDSIM 580
            C+ F E+ S  +   ++ GKGCSS IG + N    +T  D C++     HE  H LG +H H+R DRD +L I L NVS    HN+ +        PY++ S M
Sbjct:   13 CVTFEENCSIPNRVQLVNGKGCSSYIGMN-NIVQHLTFNDTCIDFGTAVHELMHALGVIHTHSRLDRDNFLNINLTNVSKEMMHNYAIFNQSTNVVPYEYGSTM 115
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Celegans
Match: nas-12 (Zinc metalloproteinase nas-12 [Source:UniProtKB/Swiss-Prot;Acc:Q9XTD6])

HSP 1 Score: 69.707 bits (169), Expect = 3.994e-14
Identity = 49/175 (28.00%), Postives = 78/175 (44.57%), Query Frame = 2 
Query:  101 DMILSEKDILR----------ING--FKAAQAALWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKS-DVHATVIMGKGCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTSTP--YDFDSIM 580
            DM+L+   ++R          I G   K +    W +    Y+  P Y    K  +   L+ +E    +C KF E  + + +  ++   GC S +G    ++  ++L   C+    + HE  H +GF HEH RPDRD ++++   NV P    NF   +      P  YDF SIM
Sbjct:   49 DMLLTPAQLIRYENSKDSDLSIRGVSIKGSSMNRWSNNIVPYVISPQYSPAQKQILVSSLRYFERV--SCFKFVERTTQNDYLFIVPLDGCYSYVGKIGGRQT-LSLAADCIADYIIWHEMMHAIGFEHEHQRPDRDSFIRVDYANVIPGQMINFDKLKTSHVEYPDIYDFKSIM 220
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Celegans
Match: nas-14 (Zinc metalloproteinase nas-14 [Source:UniProtKB/Swiss-Prot;Acc:Q19269])

HSP 1 Score: 68.1662 bits (165), Expect = 1.580e-13
Identity = 48/174 (27.59%), Postives = 76/174 (43.68%), Query Frame = 2 
Query:   98 DDMILSEKDILRINGFKAA------QAALWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSD----VHATVIMGKGCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGC---KTSTPYDFDSIM 580
            DD +L E +I R   F +A         LWP+    Y+ +    +  +  I +    Y+ +   C++F     D    ++    +  GCSS +G     +      D C +K  + HE  H LGF HEH+R DRD ++ I  +N+ P    NF             PYD++S+M
Sbjct:   97 DDPLLDEDEIFR-KPFHSALNLVTYPDKLWPEGQVPYMLEEGMTNDQRTAIAQAFDEYKTK--TCVRFVPKTDDDFDYIYVKRNVAFGCSSYVGRAGGNQTVSLEVDKCFSKGIIAHELMHALGFFHEHSRTDRDDFVDINEDNIRPGMMRNFEKYPRKIIDSLGMPYDYESVM 267
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Fly
Match: CG11865 (gene:FBgn0028947 transcript:FBtr0080753)

HSP 1 Score: 77.0258 bits (188), Expect = 3.530e-17
Identity = 50/187 (26.74%), Postives = 79/187 (42.25%), Query Frame = 2 
Query:   56 GCSQKGIKVTNFNIDDMILSEKDILRING------FKAAQAALWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIM---GKGCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTST---PYDFDSIM 580
            G S  G        DD+IL  + +    G       K+     W  +T  Y +   +   +   I   +   E     C+KF   +      V++   G GC S +GY    +  + L   C++ R ++HE  H LGF H H+ P RD+Y++I  +N+   + HNF        +     YD+DSIM
Sbjct:   13 GSSANGRPSIKLQEDDIILISEQLQYFEGNLEGRVVKSWSEYYWKGRTLVYSYAGGFSSLDIASIESAMA--EISSKTCVKFRRTEYKREPQVVIQKEGSGCWSYVGYLGRADQTLNLGSGCMSNRTIQHELLHALGFFHTHSDPQRDKYVRIQTDNIRSGHEHNFQRLRANGVTNYGFGYDYDSIM 197
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Fly
Match: CG6763 (gene:FBgn0039069 transcript:FBtr0084378)

HSP 1 Score: 72.0182 bits (175), Expect = 6.720e-15
Identity = 47/164 (28.66%), Postives = 74/164 (45.12%), Query Frame = 2 
Query:  101 DMILSEKDILRINGFKAAQAALWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMG--KGCSSSIGYDKNK-ELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKT-STPYDFDSIM 580
            DM++ + D++  NG    Q++ WP+    Y    ++  R+   I   +  Y      C++F +  S+     I G   GC SS+G    K E+ +  P          HE  H LGF+HE  R +RD Y+ I   NV  +  +NF      +    PYD+ S+M
Sbjct:   96 DMLVPQTDLIMKNGLPT-QSSRWPNGVVPYEIRGNFNARDMATIENAIGEYHRR--TCIRFVKRSSERDYISIRGDNSGCWSSVGRVGGKQEVNLQSPGCLSRPGTAMHELMHALGFLHEQNRMERDGYVAIQYNNVQSSAMNNFEKAARTEAFGVPYDYGSVM 256
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Fly
Match: CG6763 (gene:FBgn0039069 transcript:FBtr0334497)

HSP 1 Score: 72.0182 bits (175), Expect = 6.720e-15
Identity = 47/164 (28.66%), Postives = 74/164 (45.12%), Query Frame = 2 
Query:  101 DMILSEKDILRINGFKAAQAALWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMG--KGCSSSIGYDKNK-ELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKT-STPYDFDSIM 580
            DM++ + D++  NG    Q++ WP+    Y    ++  R+   I   +  Y      C++F +  S+     I G   GC SS+G    K E+ +  P          HE  H LGF+HE  R +RD Y+ I   NV  +  +NF      +    PYD+ S+M
Sbjct:   96 DMLVPQTDLIMKNGLPT-QSSRWPNGVVPYEIRGNFNARDMATIENAIGEYHRR--TCIRFVKRSSERDYISIRGDNSGCWSSVGRVGGKQEVNLQSPGCLSRPGTAMHELMHALGFLHEQNRMERDGYVAIQYNNVQSSAMNNFEKAARTEAFGVPYDYGSVM 256
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Fly
Match: CG6696 (gene:FBgn0030947 transcript:FBtr0074611)

HSP 1 Score: 67.0106 bits (162), Expect = 3.458e-13
Identity = 52/166 (31.33%), Postives = 79/166 (47.59%), Query Frame = 2 
Query:  107 ILSEKDILRINGFKAAQAALWPDKTARYIFDPSYPDRNKNRIREYLKIY-EGELGNCLKFYE-DKSDVHATVIMG--KGCSSSIGYDKNKE-LRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTS---TPYDFDSIM 580
            I+  +++LR NG    +   WP+    +  DP   D N N+    LK + E     C++F   ++ D H  +I G   GC SS+G     + L +  P  CV    V HE  H LGF H+ +  +RD+Y+KI  EN+   + HNF        +     YD+ S+M
Sbjct:   87 IMLHRELLR-NGL-LNERLTWPEAAVPFYIDPQ--DFNANQTMVILKAFKEYHDRTCIRFRPYEQGDKHWLLIKGNYSGCWSSVGRRSGGQVLNLNTPK-CVTHGVVVHELLHALGFYHQQSATERDEYVKINWENILDGHAHNFNKYARTHITNFGVEYDYQSVM 247
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Fly
Match: CG7631 (gene:FBgn0028945 transcript:FBtr0080754)

HSP 1 Score: 64.3142 bits (155), Expect = 2.277e-12
Identity = 41/155 (26.45%), Postives = 71/155 (45.81%), Query Frame = 2 
Query:  146 KAAQAALWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFY---EDKSDVHATVIMGKGCSSSIGYDKNKELRITLPDV----CVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTS---TPYDFDSIM 580
            + ++   WP+ T  Y     +   +   I+  ++  E    +C++F    ED+ +    +    GCSS +GY   +      P      C     ++HE  H LGF H+   P+RD+++KI+ EN+S  +  NF   E  +      PYD+ SI+
Sbjct:   52 QLSETRRWPNATVPYRISEEFDAPHVEYIKLGMQFIE--YSSCIRFVPADEDEENYLFVLPSTSGCSSKVGYQPGERTVKLKPGSLDTGCFKLGTIQHELLHTLGFHHQQCSPNRDEFVKIVEENISEGHEKNFVKYEEDEVGDFDQPYDYGSIL 204
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Zebrafish
Match: tll1 (tolloid-like 1 [Source:NCBI gene;Acc:474335])

HSP 1 Score: 80.4925 bits (197), Expect = 2.239e-17
Identity = 45/145 (31.03%), Postives = 75/145 (51.72%), Query Frame = 2 
Query:  164 LWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMGK---GCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTST---PYDFDSIM 580
            +WP     Y+   ++    +  +++ ++ +E +   C+ F E K+D  + ++      GC S +G   N    I++   C     V HE  H++GF HEHTRPDRD ++ I+ +N+ P   +NF   E    ++   PYDFDSIM
Sbjct:  165 IWPGGVIPYVIGGNFTGSQRAMLKQAMRHWEKQ--TCVTFIE-KTDEESYIVFTYRPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDDHVTIIRDNIQPGQEYNFIKMEPGDVNSLGEPYDFDSIM 306
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Zebrafish
Match: tll1 (tolloid-like 1 [Source:NCBI gene;Acc:474335])

HSP 1 Score: 80.4925 bits (197), Expect = 2.239e-17
Identity = 45/145 (31.03%), Postives = 75/145 (51.72%), Query Frame = 2 
Query:  164 LWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMGK---GCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTST---PYDFDSIM 580
            +WP     Y+   ++    +  +++ ++ +E +   C+ F E K+D  + ++      GC S +G   N    I++   C     V HE  H++GF HEHTRPDRD ++ I+ +N+ P   +NF   E    ++   PYDFDSIM
Sbjct:  165 IWPGGVIPYVIGGNFTGSQRAMLKQAMRHWEKQ--TCVTFIE-KTDEESYIVFTYRPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDDHVTIIRDNIQPGQEYNFIKMEPGDVNSLGEPYDFDSIM 306
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Zebrafish
Match: tll1 (tolloid-like 1 [Source:NCBI gene;Acc:474335])

HSP 1 Score: 80.4925 bits (197), Expect = 2.239e-17
Identity = 45/145 (31.03%), Postives = 75/145 (51.72%), Query Frame = 2 
Query:  164 LWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMGK---GCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTST---PYDFDSIM 580
            +WP     Y+   ++    +  +++ ++ +E +   C+ F E K+D  + ++      GC S +G   N    I++   C     V HE  H++GF HEHTRPDRD ++ I+ +N+ P   +NF   E    ++   PYDFDSIM
Sbjct:  165 IWPGGVIPYVIGGNFTGSQRAMLKQAMRHWEKQ--TCVTFIE-KTDEESYIVFTYRPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDDHVTIIRDNIQPGQEYNFIKMEPGDVNSLGEPYDFDSIM 306
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Zebrafish
Match: he1.2 (hatching enzyme 1, tandem dupliate 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2100])

HSP 1 Score: 75.0998 bits (183), Expect = 4.019e-16
Identity = 42/132 (31.82%), Postives = 64/132 (48.48%), Query Frame = 2 
Query:  188 YIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMGK-GCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTSTPYDFDSIM 580
            Y+    +   +K+ I   + I+  +   C++F           I  K GC S+IG    K++       CV     +HE  H LGF HE +R DRDQY++I   N+SP   +NF   +    +TPYD+ S+M
Sbjct:   88 YVVSGEFSINDKSVIANAISIFHAQ--TCIRFVPRSIQADYLSIENKDGCYSAIGRTGGKQVVSLNRKGCVYSGIAQHELNHALGFYHEQSRSDRDQYVRINWNNISPGMAYNFLKQKTNNQNTPYDYGSLM 217
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Zebrafish
Match: he1.1 (hatching enzyme 1, tandem duplicate 1 [Source:ZFIN;Acc:ZDB-GENE-021211-3])

HSP 1 Score: 75.0998 bits (183), Expect = 4.186e-16
Identity = 42/132 (31.82%), Postives = 64/132 (48.48%), Query Frame = 2 
Query:  188 YIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMGK-GCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTSTPYDFDSIM 580
            Y+    +   +K+ I   + I+  +   C++F           I  K GC S+IG    K++       CV     +HE  H LGF HE +R DRDQY++I   N+SP   +NF   +    +TPYD+ S+M
Sbjct:   88 YVVSGEFSINDKSVIANAISIFHAQ--TCIRFVPRSIQADYLSIENKDGCYSAIGRTGGKQVVSLNRKGCVYSGIAQHELNHALGFYHEQSRSDRDQYVRINWNNISPGMAYNFLKQKTNNQNTPYDYGSLM 217
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BLAST of Metalloendopeptidase vs. Ensembl Xenopus
Match: asb14 (ankyrin repeat and SOCS box containing 14 [Source:Xenbase;Acc:XB-GENE-6465005])

HSP 1 Score: 79.7221 bits (195), Expect = 5.813e-17
Identity = 50/180 (27.78%), Postives = 83/180 (46.11%), Query Frame = 2 
Query:   74 IKVTNFNIDDMILSEKDILRINGFKAAQAA------LWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMGK--GCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTST---PYDFDSIM 580
            I   + + D M + + +  ++   +  +AA      +WPD    Y+   ++    +   R+ ++ +E     C+ F E   +    V   +  GC S +G        I++   C     V HE  H++GF HEHTRPDRD ++ I+ EN+ P   +NF   E  +  +    YDFDSIM
Sbjct:   47 ISTDSNDYDSMSIEQSEKTKVRRSRERRAATSRPERVWPDGVIPYVISGNFSGSQRAIFRQAMRHWEKH--TCVTFLERTDEDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDDHVSIIRENIQPGQEYNFLKMEPEEVESLGETYDFDSIM 224
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Xenopus
Match: asb14 (ankyrin repeat and SOCS box containing 14 [Source:Xenbase;Acc:XB-GENE-6465005])

HSP 1 Score: 78.5666 bits (192), Expect = 1.451e-16
Identity = 50/180 (27.78%), Postives = 80/180 (44.44%), Query Frame = 2 
Query:   80 VTNFNIDDMILSEKDIL--------RINGFKAAQAALWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMGK--GCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTST---PYDFDSIM 580
            + NF +D ++   K  +        R     +    +WPD    Y+   ++    +   R+ ++ +E     C+ F E   +    V   +  GC S +G        I++   C     V HE  H++GF HEHTRPDRD ++ I+ EN+ P   +NF   E  +  +    YDFDSIM
Sbjct:   20 LANFKVDRIVDLTKHTISTASNKRDRTEAATSRPERVWPDGVIPYVISGNFSGSQRAIFRQAMRHWEKH--TCVTFLERTDEDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDDHVSIIRENIQPGQEYNFLKMEPEEVESLGETYDFDSIM 197
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Xenopus
Match: asb14 (ankyrin repeat and SOCS box containing 14 [Source:Xenbase;Acc:XB-GENE-6465005])

HSP 1 Score: 77.0258 bits (188), Expect = 4.247e-16
Identity = 45/144 (31.25%), Postives = 69/144 (47.92%), Query Frame = 2 
Query:  164 LWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMGK--GCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTST---PYDFDSIM 580
            +WPD    Y+   ++    +   R+ ++ +E     C+ F E   +    V   +  GC S +G        I++   C     V HE  H++GF HEHTRPDRD ++ I+ EN+ P   +NF   E  +  +    YDFDSIM
Sbjct:  118 VWPDGVIPYVISGNFSGSQRAIFRQAMRHWEKH--TCVTFLERTDEDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDDHVSIIRENIQPGQEYNFLKMEPEEVESLGETYDFDSIM 259
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Xenopus
Match: asb14 (ankyrin repeat and SOCS box containing 14 [Source:Xenbase;Acc:XB-GENE-6465005])

HSP 1 Score: 77.0258 bits (188), Expect = 4.761e-16
Identity = 45/144 (31.25%), Postives = 69/144 (47.92%), Query Frame = 2 
Query:  164 LWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMGK--GCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTST---PYDFDSIM 580
            +WPD    Y+   ++    +   R+ ++ +E     C+ F E   +    V   +  GC S +G        I++   C     V HE  H++GF HEHTRPDRD ++ I+ EN+ P   +NF   E  +  +    YDFDSIM
Sbjct:  123 VWPDGVIPYVISGNFSGSQRAIFRQAMRHWEKH--TCVTFLERTDEDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDDHVSIIRENIQPGQEYNFLKMEPEEVESLGETYDFDSIM 264
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Xenopus
Match: golt1b (golgi transport 1B [Source:Xenbase;Acc:XB-GENE-5753086])

HSP 1 Score: 76.6406 bits (187), Expect = 4.870e-16
Identity = 43/133 (32.33%), Postives = 65/133 (48.87%), Query Frame = 2 
Query:  188 YIFDPSYPDRNKNRIREYLKIYEGELGNCLKF--YEDKSDVHATVIMGKGCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTSTPYDFDSIM 580
            Y  D  Y +   N I   +++Y      C++F  Y D+ D +  +  G GC S +G     ++       C ++    HE  H LGF+HEH+R DRD Y+ I+ + +SP    NF   E    +T YD+ SIM
Sbjct:   85 YTLDEQYSNNEVNTIMTAMQVYATL--TCVQFVPYTDEDD-YIAITSGDGCWSYMGRQGGAQVVSVQKTYCTSEGTTMHELNHALGFVHEHSRSDRDNYVDIMYQYISPGDIVNFKKMETNNLNTTYDYHSIM 214
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BLAST of Metalloendopeptidase vs. Ensembl Mouse
Match: Tll2 (tolloid-like 2 [Source:MGI Symbol;Acc:MGI:1346044])

HSP 1 Score: 79.337 bits (194), Expect = 5.141e-17
Identity = 45/145 (31.03%), Postives = 73/145 (50.34%), Query Frame = 2 
Query:  164 LWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMGK---GCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTST---PYDFDSIM 580
            +WP     Y+   ++    +   ++ ++ +E     C+ F E ++D  + ++      GC S +G        I++   C     V HE  H++GF HEHTRPDRDQ++ I+ EN+ P   +NF   E  + S+    YDFDSIM
Sbjct:  155 IWPGGVIPYVIGGNFTGTQRAIFKQAMRHWEKH--TCVTFVE-RTDEESFIVFSYRTCGCCSYVGRRGGGPQAISIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIM 296
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Mouse
Match: Tll2 (tolloid-like 2 [Source:MGI Symbol;Acc:MGI:1346044])

HSP 1 Score: 79.337 bits (194), Expect = 5.228e-17
Identity = 45/145 (31.03%), Postives = 73/145 (50.34%), Query Frame = 2 
Query:  164 LWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMGK---GCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTST---PYDFDSIM 580
            +WP     Y+   ++    +   ++ ++ +E     C+ F E ++D  + ++      GC S +G        I++   C     V HE  H++GF HEHTRPDRDQ++ I+ EN+ P   +NF   E  + S+    YDFDSIM
Sbjct:  155 IWPGGVIPYVIGGNFTGTQRAIFKQAMRHWEKH--TCVTFVE-RTDEESFIVFSYRTCGCCSYVGRRGGGPQAISIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIM 296
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Mouse
Match: Tll1 (tolloid-like [Source:MGI Symbol;Acc:MGI:106923])

HSP 1 Score: 77.7962 bits (190), Expect = 2.060e-16
Identity = 45/145 (31.03%), Postives = 73/145 (50.34%), Query Frame = 2 
Query:  164 LWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMGK---GCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTST---PYDFDSIM 580
            +WP     Y+   ++    +   ++ ++ +E     C+ F E +SD  + ++      GC S +G   N    I++   C     V HE  H++GF HEHTRPDRD ++ I+ EN+ P   +NF   E  + ++    YDFDSIM
Sbjct:  156 IWPGGVIPYVIGGNFTGSQRAMFKQAMRHWEKH--TCVTFTE-RSDEESYIVFTYRPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDNHVTIIRENIQPGQEYNFLKMEPGEVNSLGERYDFDSIM 297
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Mouse
Match: Bmp1 (bone morphogenetic protein 1 [Source:MGI Symbol;Acc:MGI:88176])

HSP 1 Score: 75.485 bits (184), Expect = 1.064e-15
Identity = 44/144 (30.56%), Postives = 70/144 (48.61%), Query Frame = 2 
Query:  164 LWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMGK--GCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTST---PYDFDSIM 580
            +WPD    ++   ++    +   R+ ++ +E     C+ F E   +    V   +  GC S +G        I++   C     V HE  H++GF HEHTRPDRD+++ I+ EN+ P   +NF   E  +  +    YDFDSIM
Sbjct:  134 VWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKH--TCVTFLERTDEDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDRHVSIVRENIQPGQEYNFLKMEVQEVESLGETYDFDSIM 275
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Mouse
Match: Astl (astacin-like metalloendopeptidase (M12 family) [Source:MGI Symbol;Acc:MGI:3046414])

HSP 1 Score: 72.7886 bits (177), Expect = 8.208e-15
Identity = 47/170 (27.65%), Postives = 77/170 (45.29%), Query Frame = 2 
Query:   98 DDMILSEKDILRINGFKAAQAA--LWPDKTARYIFDPSYPDRNKNRIREYL---KIYEGELGNCLKF--YEDKSDVHATVIMGKGCSSSIGYDKNKELRITLPDVCVNKRN--VKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTSTPYDFDSIM 580
            +   L E DI+R + F+        WP     ++  P    R  + +   +      E E   C++F  Y  + D  + + M  GC S +G     ++ ++L   C+ K    V HE  H+LGF HEH+R DRD+Y+++    + P +  NF          PYD+ S+M
Sbjct:   69 ESSFLVEGDIIRPSPFRLLSVTNNKWPKGVGGFVEIPFLLSRKYDELSRRVIMDAFAEFERFTCIRFVAYHGQRDFVSILPM-AGCFSGVGRSGGMQV-VSLAPTCLRKGRGIVLHELMHVLGFWHEHSRADRDRYIQVNWNEILPGFEINFIKSRSTNMLVPYDYSSVM 236
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BLAST of Metalloendopeptidase vs. UniProt/SwissProt
Match: sp|Q6HA08|ASTL_HUMAN (Astacin-like metalloendopeptidase OS=Homo sapiens OX=9606 GN=ASTL PE=1 SV=4)

HSP 1 Score: 84.3445 bits (207), Expect = 4.345e-18
Identity = 53/172 (30.81%), Postives = 88/172 (51.16%), Query Frame = 2 
Query:   98 DDMILSEKDILRINGFK--AAQAALWPDKTA-----RYIFDPSYPDRNKNRIREYLKIYEGELGNCLKF--YEDKSDVHATVIMGKGCSSSIGYDKNKELRITLPDVCVNKRN--VKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTSTPYDFDSIM 580
            +   L E DI+R + F+  +A +  WP   +      ++    Y + ++  I E L  +E     C++F  Y+D+ D  + + M  GC SS+G     ++ ++L   C+ K    V HE  H+LGF HEHTR DRD+Y+++    + P +  NF   +     TPYD+ S+M
Sbjct:   69 ESSFLIEGDIIRPSPFRLLSATSNKWPMGGSGVVEVPFLLSSKYDEPSRQVILEALAEFE--RSTCIRFVTYQDQRDFISIIPM-YGCFSSVGRSGGMQV-VSLAPTCLQKGRGIVLHELMHVLGFWHEHTRADRDRYIRVNWNEILPGFEINFIKSQSSNMLTPYDYSSVM 236
[Close]
BLAST of Metalloendopeptidase vs. UniProt/SwissProt
Match: sp|P31579|LCE_ORYLA (Low choriolytic enzyme OS=Oryzias latipes OX=8090 GN=lce PE=1 SV=1)

HSP 1 Score: 79.7221 bits (195), Expect = 5.475e-17
Identity = 48/152 (31.58%), Postives = 74/152 (48.68%), Query Frame = 2 
Query:  143 FKAAQAALWPDKT-----ARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMGK-GCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTSTPYDFDSIM 580
            F A  +  WP  +       Y+   +Y    K  IR  +K +  +   C+ F    ++     +  + GC S +GY  +K++ +     C+    ++HE  H LGF HEHTR DRDQ++KI  EN+   + HNF   +     TPYD+ SIM
Sbjct:   77 FGAPDSCRWPKSSNGIVKVPYVVSDNYESDEKETIRNAMKEFAEK--TCIHFVPRNNERAYLSLEPRFGCKSMMGYVGDKQVVVLQRFGCIKHAVIQHELLHALGFYHEHTRSDRDQHVKINWENIIKDFTHNFDKNDTDNLGTPYDYGSIM 226
[Close]
BLAST of Metalloendopeptidase vs. UniProt/SwissProt
Match: sp|O57460|TLL1_DANRE (Dorsal-ventral patterning tolloid-like protein 1 OS=Danio rerio OX=7955 GN=tll1 PE=2 SV=1)

HSP 1 Score: 80.4925 bits (197), Expect = 1.690e-16
Identity = 45/145 (31.03%), Postives = 75/145 (51.72%), Query Frame = 2 
Query:  164 LWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMGK---GCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTST---PYDFDSIM 580
            +WP     Y+   ++    +  +++ ++ +E +   C+ F E K+D  + ++      GC S +G   N    I++   C     V HE  H++GF HEHTRPDRD ++ I+ +N+ P   +NF   E    ++   PYDFDSIM
Sbjct:  165 IWPGGVIPYVIGGNFTGSQRAMLKQAMRHWEKQ--TCVTFIE-KTDEESYIVFTYRPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDDHVTIIRDNIQPGQEYNFIKMEPGDVNSLGEPYDFDSIM 306
[Close]
BLAST of Metalloendopeptidase vs. UniProt/SwissProt
Match: sp|Q9DER7|TLL1_CHICK (Tolloid-like protein 1 OS=Gallus gallus OX=9031 GN=TLL1 PE=2 SV=1)

HSP 1 Score: 79.7221 bits (195), Expect = 2.646e-16
Identity = 46/145 (31.72%), Postives = 74/145 (51.03%), Query Frame = 2 
Query:  164 LWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMGK---GCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTST---PYDFDSIM 580
            +WP     Y+   ++    +   ++ ++ +E     C+ F E +SD  + ++      GC S +G   N    I++   C     V HE  H++GF HEHTRPDRD ++ I+ EN+ P   +NF   E  + ++   PYDFDSIM
Sbjct:  152 IWPGGVIPYVIGGNFTGTQRAMFKQAMRHWEKY--TCVTFIE-RSDEESYIVFTYRPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDDHVTIIRENIQPGQEYNFLKMEPGEVNSLGEPYDFDSIM 293
[Close]
BLAST of Metalloendopeptidase vs. UniProt/SwissProt
Match: sp|Q9Y6L7|TLL2_HUMAN (Tolloid-like protein 2 OS=Homo sapiens OX=9606 GN=TLL2 PE=1 SV=1)

HSP 1 Score: 79.7221 bits (195), Expect = 2.971e-16
Identity = 45/145 (31.03%), Postives = 73/145 (50.34%), Query Frame = 2 
Query:  164 LWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMGK---GCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTST---PYDFDSIM 580
            +WP     Y+   ++    +   ++ ++ +E     C+ F E ++D  + ++      GC S +G        I++   C     V HE  H++GF HEHTRPDRDQ++ I+ EN+ P   +NF   E  + S+    YDFDSIM
Sbjct:  158 IWPGGVIPYVIGGNFTGSQRAIFKQAMRHWEKH--TCVTFIE-RTDEESFIVFSYRTCGCCSYVGRRGGGPQAISIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIM 299
[Close]
BLAST of Metalloendopeptidase vs. TrEMBL
Match: A0A060Q6Y6 (Metalloendopeptidase OS=Schmidtea mediterranea OX=79327 GN=Ast4 PE=2 SV=1)

HSP 1 Score: 301.212 bits (770), Expect = 4.142e-101
Identity = 136/193 (70.47%), Postives = 162/193 (83.94%), Query Frame = 2 
Query:    2 LFCFIILGVGIELCYSQCGCSQKGIKVTNFNIDDMILSEKDILRINGFKAAQAALWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMGKGCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTSTPYDFDSIM 580
            +  FI L V IELC +QCGC+QKGIK++NFN+ DM+LS +D+LRINGFKAAQ   WP+K  RY FDPSYPD+NKN IRE+LKIYE ELGNCL+F E+KSDV+ATV++G GCS+++GY+KN  L ITLPD CVN+RNVKHEFTHLLGFMHEHTRPDRDQ+LKI   NV    C+NF+LCEGCK +T YDFDSIM
Sbjct:    6 IISFITLSVVIELCSAQCGCTQKGIKISNFNVGDMVLSSQDVLRINGFKAAQGVHWPNKLLRYTFDPSYPDKNKNAIREFLKIYEKELGNCLRFLEEKSDVYATVVLGGGCSANVGYNKNYPLSITLPDPCVNRRNVKHEFTHLLGFMHEHTRPDRDQFLKIEFGNVHSGLCNNFYLCEGCKLTTTYDFDSIM 198
[Close]
BLAST of Metalloendopeptidase vs. TrEMBL
Match: A0A060Q715 (Metalloendopeptidase (Fragment) OS=Schmidtea mediterranea OX=79327 GN=Ast7 PE=2 SV=1)

HSP 1 Score: 263.077 bits (671), Expect = 3.502e-86
Identity = 118/193 (61.14%), Postives = 148/193 (76.68%), Query Frame = 2 
Query:    2 LFCFIILGVGIELCYSQCGCSQKGIKVTNFNIDDMILSEKDILRINGFKAAQAALWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMGKGCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTSTPYDFDSIM 580
            + CF+++ +   LCY+QCGC+QKGIK+ +FN+ DM+LS  +IL+ING+KAA    WP    RY FDPS+PD+NKN +R++LK YE ELGNC+KF E+KS V ATV+ G GCS+++GY+    L++TL D CVNKRNVKHEFTH LGF HEHTRPDRD  L I   NV    C NF+LCEGCKT+TPYDFDSIM
Sbjct:    1 VICFLLITL-FSLCYAQCGCTQKGIKIADFNVGDMVLSPVEILKINGYKAADGEKWPKNELRYTFDPSFPDKNKNPVRDFLKAYEKELGNCIKFKEEKSGVFATVVTGGGCSANVGYNSRYPLKVTLADPCVNKRNVKHEFTHSLGFQHEHTRPDRDNNLNIQFNNVKKNLCANFYLCEGCKTTTPYDFDSIM 192
[Close]
BLAST of Metalloendopeptidase vs. TrEMBL
Match: A0A060Q786 (Metalloendopeptidase OS=Schmidtea mediterranea OX=79327 GN=Ast6 PE=2 SV=1)

HSP 1 Score: 137.117 bits (344), Expect = 1.263e-36
Identity = 71/201 (35.32%), Postives = 109/201 (54.23%), Query Frame = 2 
Query:    2 LFCFIILGVGIELCYSQCGCSQKGI---KVTNFNIDDMILSEKDILRINGFKA--AQAALWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATV-IMGKGCSSSIGY--DKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTSTPYDFDSIM 580
            LFC +++   +     QCGC ++ +    + +  + DM+L + DI  INGFKA  +    WP+    + F P++P   K  +RE L   + +LGNC+KF E  +  +  V  + +GC S +GY    N+ L +  P    +K  VKHEF H LGFMH H R DRD ++ I  + +  ++C  F  CEGC    PY+ +S+M
Sbjct:    4 LFCLLLIVAAVSYVSGQCGCPRQKLLKRGLDSMQMGDMVLDKSDIALINGFKAHYSNTKRWPNNQVLFSFAPAFPGDKKGIVRECLVELQKDLGNCVKFSESTASHYIEVHSLNQGCYSLLGYTGGPNQPLNLQNPGCMYSKGTVKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVM 204
[Close]
BLAST of Metalloendopeptidase vs. TrEMBL
Match: I1ZIC3 (Metalloendopeptidase OS=Schmidtea mediterranea OX=79327 GN=Ast3 PE=2 SV=1)

HSP 1 Score: 130.183 bits (326), Expect = 7.966e-34
Identity = 72/200 (36.00%), Postives = 105/200 (52.50%), Query Frame = 2 
Query:    5 FCFIILGVGIELCYSQCGCSQKGI---KVTNFNIDDMILSEKDILRINGFKAAQ--AALWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATV-IMGKGCSSSIG--YDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTSTPYDFDSIM 580
            F  +I+ V      SQCGC++K +      N ++ DM+LS+ DI  INGFK  Q  A  WP     + F   +P   +N +++ L   + +LGNC++F+E     H  V    KGC + IG   ++ + L +  P    +K  +KHEF H LGFMH H R DRD ++ I   N+  + C NF  CEGC     Y+  S+M
Sbjct:    8 FLILIVLVLANEVASQCGCNKKKLMTRATENLHVGDMLLSKADIAIINGFKHHQREARAWPGGKVSFAFANDFPADKRNLVKQCLNELQSDLGNCVQFFESTQGPHIAVHAQNKGCYAMIGCTGERGQFLNLQNPWCMNSKGTIKHEFIHALGFMHTHMRMDRDNFISINWRNIQSSQCFNFVKCEGCIMDGNYETRSVM 207
[Close]
BLAST of Metalloendopeptidase vs. TrEMBL
Match: A0A060Q750 (Metalloendopeptidase OS=Schmidtea mediterranea OX=79327 GN=Ast5 PE=2 SV=1)

HSP 1 Score: 120.939 bits (302), Expect = 2.579e-30
Identity = 66/201 (32.84%), Postives = 102/201 (50.75%), Query Frame = 2 
Query:    2 LFCFIILGVGIELCYSQCGCSQKGIK-VTNFNIDDMILSEKDILRINGFKA--AQAALWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMGK-GCSSSIGY----DKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTSTPYDFDSIM 580
            LF   IL + + +   +CGC +  +K   +  IDDM+L   D+++I GF+     A  W D T +Y F P +P   K  +RE +     +L  C+K+ E  S  H  V   + GC S +G       ++EL +  P    +K  +KHEF H  GFMH   R DRD+++ I  E +   +CH F  C+ C+ +  Y  +S+M
Sbjct:    8 LFLLSILNL-VFIEAGKCGCQKSKLKRAISLKIDDMLLDHVDLMKIEGFRGYDKNARRWTDNTLKYTFHPQFPADKKQIVRESMNELTNDLKGCVKYVESTSGYHIKVQSHQPGCWSFVGMLNKQGGSQELNLENPGCLYSKGTIKHEFIHATGFMHTQMRADRDKFVNIFWERIDSDFCHAFVTCKNCEETVTYKTNSVM 207
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Cavefish
Match: c6ast1 (low choriolytic enzyme-like [Source:NCBI gene;Acc:103036149])

HSP 1 Score: 85.8853 bits (211), Expect = 3.357e-20
Identity = 55/174 (31.61%), Postives = 85/174 (48.85%), Query Frame = 2 
Query:   98 DDMILSEKDILRINGFKAAQ-------AALWPDKT-----ARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFY-EDKSDVHATVIMGKGCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTSTPYDFDSIM 580
            +D  ++  DIL  +G + A        + LWP          YI    +  + K  I + LK +      C++F   D+ + +  +   KGC SS+G    ++        C+ KR V+HEF H LGF HE +R DRDQ+++I+ EN+ P   HNF   +     TPYD+ S+M
Sbjct:   62 EDPTITFGDILVDDGLQNADPCTSRNPSCLWPKNKNGIVYVPYIISNQFCPKEKKLITDILKTFRNST--CIQFVPRDREEDYIHIQNLKGCYSSVGRRGGEQTLSLSRQGCLYKRAVQHEFIHALGFHHEQSRSDRDQHIRIVYENIDPDKKHNFNKVDTNNLKTPYDYGSVM 233
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Cavefish
Match: c6ast1 (low choriolytic enzyme-like [Source:NCBI gene;Acc:111191947])

HSP 1 Score: 79.337 bits (194), Expect = 7.678e-18
Identity = 52/175 (29.71%), Postives = 85/175 (48.57%), Query Frame = 2 
Query:   95 IDDMILSEKDILRINGFKAAQ-------AALWP-----DKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFY-EDKSDVHATVIMGKGCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTSTPYDFDSIM 580
            ++D  +   DIL  +G + A        + +WP     +    YI    +    K+ I   LK +E     C++F   D+ + +  V   +GC S +G    ++        C+ K+ ++HEF H LGF HE  R DRD++++IL EN+ P   HNF   +    +TPYD+ S+M
Sbjct:   50 LEDPTIRFGDILVDDGLQNADRCTSRKPSCMWPMNSDGNTYIPYIISNQFSPNEKDLITSVLKTFEKS--TCIRFKPRDREEDYIDVQSLEGCYSFVGRTGGRQTLSLKSRGCLYKKIIQHEFLHALGFHHEQCRSDRDKHIRILYENIDPGKEHNFDKKDTNNLNTPYDYGSVM 222
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Cavefish
Match: c6ast1 (low choriolytic enzyme-like [Source:NCBI gene;Acc:111191947])

HSP 1 Score: 79.337 bits (194), Expect = 9.445e-18
Identity = 52/175 (29.71%), Postives = 85/175 (48.57%), Query Frame = 2 
Query:   95 IDDMILSEKDILRINGFKAAQ-------AALWP-----DKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFY-EDKSDVHATVIMGKGCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTSTPYDFDSIM 580
            ++D  +   DIL  +G + A        + +WP     +    YI    +    K+ I   LK +E     C++F   D+ + +  V   +GC S +G    ++        C+ K+ ++HEF H LGF HE  R DRD++++IL EN+ P   HNF   +    +TPYD+ S+M
Sbjct:   61 LEDPTIRFGDILVDDGLQNADRCTSRKPSCMWPMNSDGNTYIPYIISNQFSPNEKDLITSVLKTFEKST--CIRFKPRDREEDYIDVQSLEGCYSFVGRTGGRQTLSLKSRGCLYKKIIQHEFLHALGFHHEQCRSDRDKHIRILYENIDPGKEHNFDKKDTNNLNTPYDYGSVM 233
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Cavefish
Match: tll1 (tolloid-like 1 [Source:NCBI gene;Acc:474335])

HSP 1 Score: 80.4925 bits (197), Expect = 1.774e-17
Identity = 48/162 (29.63%), Postives = 82/162 (50.62%), Query Frame = 2 
Query:  113 SEKDILRINGFKAAQAALWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMGK---GCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTST---PYDFDSIM 580
            S+  + R    +A +  +WP     Y+   ++    +   ++ ++ +E +   C+ F E K+D  + ++      GC S +G   N    I++   C     V HE  H++GF HEHTRPDRD ++ I+ +N+ P   +NF   E  + ++   PYDFDSIM
Sbjct:   35 SQAQVPRAATSRAER--IWPGGVIPYVIGGNFTGSQRAMFKQAMRHWEKQ--TCVTFIE-KTDEESYIVFTYRPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDDHVTIIRDNIQPGQEYNFLKMEPGEVNSLGEPYDFDSIM 191
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Cavefish
Match: tll1 (tolloid-like 1 [Source:NCBI gene;Acc:474335])

HSP 1 Score: 80.1073 bits (196), Expect = 2.081e-17
Identity = 45/145 (31.03%), Postives = 75/145 (51.72%), Query Frame = 2 
Query:  164 LWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMGK---GCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTST---PYDFDSIM 580
            +WP     Y+   ++    +   ++ ++ +E +   C+ F E K+D  + ++      GC S +G   N    I++   C     V HE  H++GF HEHTRPDRD ++ I+ +N+ P   +NF   E  + ++   PYDFDSIM
Sbjct:  150 IWPGGVIPYVIGGNFTGSQRAMFKQAMRHWEKQ--TCVTFIE-KTDEESYIVFTYRPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDDHVTIIRDNIQPGQEYNFLKMEPGEVNSLGEPYDFDSIM 291
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007253.1 (pep scaffold:Pmarinus_7.0:GL476910:54360:144194:-1 gene:ENSPMAG00000006538.1 transcript:ENSPMAT00000007253.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 75.0998 bits (183), Expect = 2.488e-16
Identity = 50/165 (30.30%), Postives = 77/165 (46.67%), Query Frame = 2 
Query:  113 SEKDILRINGFKAAQAA---LWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMGK---GCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTST---PYDFDSIM 580
            + K   R    +AA A    +WP     YI   ++    K   R+ ++ +E     C+ F E ++D  + ++      GC S +G        I++   C     V HE  H++GF HEHTRPDRD ++ I+  N+ P   +NF   E  +  +    YDFDSIM
Sbjct:    1 AAKRRFRSRAPRAATARSERIWPGGVIPYIVGGNFTGSQKAMFRQAMRHWEKH--TCVTFIE-RTDEESYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDDHVTIIKANIQPGQEYNFLKMEPGEVDSLGESYDFDSIM 162
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004913.1 (pep scaffold:Pmarinus_7.0:GL478359:22377:26907:1 gene:ENSPMAG00000004462.1 transcript:ENSPMAT00000004913.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 50.0618 bits (118), Expect = 2.644e-8
Identity = 26/84 (30.95%), Postives = 39/84 (46.43%), Query Frame = 2 
Query:  332 CSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKT-STPYDFDSIM 580
            C S +G     E  +++   C     V HE  H +G++HE +RPDRD ++ +L  NV       F +         PYD  S+M
Sbjct:    1 CWSFVGMIGVGEQVVSIGRGCEGVGTVAHELGHAVGYVHEQSRPDRDAFISVLEGNVQDGQLPQFAVYSATDPRGVPYDLKSVM 84
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Nematostella
Match: EDO41420 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4I5])

HSP 1 Score: 88.5817 bits (218), Expect = 5.802e-22
Identity = 52/158 (32.91%), Postives = 76/158 (48.10%), Query Frame = 2 
Query:  119 KDILRINGFKAAQAALWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSD-VHATVIMGKGCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGC---KTSTPYDFDSIM 580
            +DI   +     +   WP+    Y  D S  +R  N IR  +K++      C++F E  ++  +A    G+GCSS +G    ++  I+L   C     V HE  H LGF HE +RPDRD Y+ I   N+SP    NF +          TPYD+ S+M
Sbjct:   25 QDIDSPSARGGIKTGRWPEGVMAYTIDRSLSNRAMNAIRAGMKMWTDN--TCIRFKERTNEYAYARFWRGRGCSSMVGRTGRRQ-DISLAGGCWYPGTVAHEIGHALGFYHEQSRPDRDNYVTIHWNNISPNMKFNFNMYPRSTIDSLGTPYDYRSVM 179
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Nematostella
Match: EDO44568 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RVF7])

HSP 1 Score: 84.7297 bits (208), Expect = 8.825e-20
Identity = 49/146 (33.56%), Postives = 79/146 (54.11%), Query Frame = 2 
Query:  164 LWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVH-ATVIMGKGCSSSIG---YDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTST---PYDFDSIM 580
            LW +K   Y F+  +P+  +  I E ++ Y  +   CL+F E   + +    +  KGC SS+G   + ++    ++L   C +K+ + HE  H +GF HE +RPDR++Y+++L EN+     HNF      +  T   PYDFDSIM
Sbjct:   43 LWTNKIIPYQFESGFPNDLRPTILEAMEEYHKK--TCLRFKERTDERYFLRFVNKKGCWSSVGRSYWVEDVGQEVSLGSGCNDKKIIMHELMHAIGFWHEQSRPDRNKYVEVLWENIQEGEAHNFNKYSHGEIDTLQVPYDFDSIM 186
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Nematostella
Match: EDO42421 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S1T1])

HSP 1 Score: 80.1073 bits (196), Expect = 4.579e-19
Identity = 47/144 (32.64%), Postives = 69/144 (47.92%), Query Frame = 2 
Query:  164 LWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMG--KGCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKT---STPYDFDSIM 580
            LWP     Y  DP +   ++   +    I + E   C++F +  ++ +  V +    GC S +G    K+  ++L   C +K  + HE  H LGF HE TRPDRD Y+ IL EN+      NF      +     TPYD+ SIM
Sbjct:   11 LWPGGVVVYELDPRFERSSRAMEKLTQAISDYEKYTCIRFRKKTANDNDYVYIKDRGGCRSHVGRKGGKQY-LSLSSGCWHKGTIIHELGHALGFFHEQTRPDRDDYVTILFENIRLGMASNFMKHSAGEVDSLGTPYDYGSIM 153
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Nematostella
Match: EDO31997 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SWD8])

HSP 1 Score: 75.485 bits (184), Expect = 2.523e-18
Identity = 37/89 (41.57%), Postives = 53/89 (59.55%), Query Frame = 2 
Query:  272 CLKFYEDKSD-VHATVIMGKGCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLC 535
            C++F E  ++  +AT   G GCSS +G  KN++  I+L + C +   V HE  H LGF HE +RPDRD Y+ I + NV      N+F+C
Sbjct:    9 CIRFKERTNERAYATFHFGSGCSSEVGM-KNRQQHISLGNGCWHAGVVAHEIAHALGFFHEQSRPDRDNYVTIYINNVEGCKISNYFIC 96
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Nematostella
Match: EDO45037 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RU87])

HSP 1 Score: 79.7221 bits (195), Expect = 2.681e-18
Identity = 50/162 (30.86%), Postives = 80/162 (49.38%), Query Frame = 2 
Query:  110 LSEKDILRIN-GFKAAQAALWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDV-HATVIMGKGCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTS---TPYDFDSIM 580
            ++ +D+ +   G  +    LWP+    Y  DP+      N I   +KI+E +   C++F +  ++  +  V +G GC+S +G   N++L ++L   C     V HEF H LGF HE +RPDRD Y+ I   N+   Y   F        +   T YD+ S+M
Sbjct:   22 MTGRDVSKAGLGRASINKNLWPNGVLVYQLDPAIESDAMNAINAAIKIWEQK--TCIRFKKRTNEQDYCYVHIGAGCTSYVGRQGNRQL-VSLARGCWLTHTVAHEFGHALGFYHEQSRPDRDNYVTINWNNIYDRYKFAFNKYPASTINSLGTEYDYGSVM 180
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Medaka
Match: mnep (nephrosin [Source:NCBI gene;Acc:100049315])

HSP 1 Score: 89.3521 bits (220), Expect = 1.738e-21
Identity = 55/174 (31.61%), Postives = 85/174 (48.85%), Query Frame = 2 
Query:   92 NIDDMILSEKDILRINGFK-----AAQAALWPDKTARYIFDP-----SYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMGK-GCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTSTPYDFDSIM 580
            N+DD ++   DI    G +      A+  LWP  +   ++ P      +  R ++ I + L+ +EG    C++F   +S      I  + GC S +G     ++   +   CV    ++HE  H LGF HE TR DRD +++ILL+NV     HNF   E     TPYD++SIM
Sbjct:   57 NLDDPLVMFGDIAVPTGLQNADPCTARGCLWPKSSDGNVYVPFRISGQFSSRERDTILQGLRSFEGS--TCIRFTPHQSQRDFVDIQSRTGCWSFVGRRGGGQVVSLMRQGCVFMGTIQHELLHALGFNHEQTRSDRDSHVRILLQNVISGQEHNFRKIETRNLGTPYDYNSIM 228
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Medaka
Match: mnep (nephrosin [Source:NCBI gene;Acc:100049315])

HSP 1 Score: 89.7373 bits (221), Expect = 1.821e-21
Identity = 55/174 (31.61%), Postives = 85/174 (48.85%), Query Frame = 2 
Query:   92 NIDDMILSEKDILRINGFK-----AAQAALWPDKTARYIFDP-----SYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMGK-GCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTSTPYDFDSIM 580
            N+DD ++   DI    G +      A+  LWP  +   ++ P      +  R ++ I + L+ +EG    C++F   +S      I  + GC S +G     ++   +   CV    ++HE  H LGF HE TR DRD +++ILL+NV     HNF   E     TPYD++SIM
Sbjct:   52 NLDDPLVMFGDIAVPTGLQNADPCTARGCLWPKSSDGNVYVPFRISGQFSSRERDTILQGLRSFEGS--TCIRFTPHQSQRDFVDIQSRTGCWSFVGRRGGGQVVSLMRQGCVFMGTIQHELLHALGFNHEQTRSDRDSHVRILLQNVISGQEHNFRKIETRNLGTPYDYNSIM 223
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Medaka
Match: lce (protease [Source:NCBI gene;Acc:100049451])

HSP 1 Score: 79.7221 bits (195), Expect = 6.109e-18
Identity = 48/152 (31.58%), Postives = 74/152 (48.68%), Query Frame = 2 
Query:  143 FKAAQAALWPDKT-----ARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMGK-GCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTSTPYDFDSIM 580
            F A  +  WP  +       Y+   +Y    K  IR  +K +  +   C+ F    ++     +  + GC S +GY  +K++ +     C+    ++HE  H LGF HEHTR DRDQ++KI  EN+   + HNF   +     TPYD+ SIM
Sbjct:   77 FGAPDSCRWPKSSNGIVKVPYVVSDNYESDEKETIRNAMKEFAEK--TCIHFVPRNNERAYLSLEPRFGCKSMMGYVGDKQVVVLQRFGCIKHAVIQHELLHALGFYHEHTRSDRDQHVKINWENIIKDFTHNFDKNDTDNLGTPYDYGSIM 226
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Medaka
Match: lce (protease [Source:NCBI gene;Acc:100049451])

HSP 1 Score: 79.7221 bits (195), Expect = 6.172e-18
Identity = 48/152 (31.58%), Postives = 74/152 (48.68%), Query Frame = 2 
Query:  143 FKAAQAALWPDKT-----ARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMGK-GCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTSTPYDFDSIM 580
            F A  +  WP  +       Y+   +Y    K  IR  +K +  +   C+ F    ++     +  + GC S +GY  +K++ +     C+    ++HE  H LGF HEHTR DRDQ++KI  EN+   + HNF   +     TPYD+ SIM
Sbjct:   77 FGAPDSCRWPKSSNGIVKVPYVVSDNYESDEKETIRNAMKEFAEK--TCIHFVPRNNERAYLSLEPRFGCKSMMGYVGDKQVVVLQRFGCIKHAVIQHELLHALGFYHEHTRSDRDQHVKINWENIIKDFTHNFDKNDTDNLGTPYDYGSIM 226
[Close]
BLAST of Metalloendopeptidase vs. Ensembl Medaka
Match: tll1 (tolloid like 1 [Source:NCBI gene;Acc:101160961])

HSP 1 Score: 80.4925 bits (197), Expect = 1.490e-17
Identity = 49/179 (27.37%), Postives = 88/179 (49.16%), Query Frame = 2 
Query:   62 SQKGIKVTNFNIDDMILSEKDILRINGFKAAQAALWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMGK---GCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTST---PYDFDSIM 580
            S+    +    +++  + +  I R    +A +  +WP     Y+   ++    +   ++ ++ +E +   C+ F E K+D  + ++      GC S +G   N    I++   C     V HE  H++GF HEHTRPDRD ++ I+ +N+ P   +NF   E  + ++   PYDFDSIM
Sbjct:   35 SKDSTSIKTQTVNNGKVGKSRIPRAATSRAER--IWPGGVIPYVIGGNFTGSQRAMFKQAMRHWEKQ--TCVTFIE-KTDEESYIVFTYRPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDDHVTIIRDNIQPGQEYNFLKMEPGEVNSLGEPYDFDSIM 208
[Close]
BLAST of Metalloendopeptidase vs. Planmine SMEST
Match: SMESG000016662.1 (SMESG000016662.1)

HSP 1 Score: 405.216 bits (1040), Expect = 8.775e-146
Identity = 193/193 (100.00%), Postives = 193/193 (100.00%), Query Frame = 2 
Query:    2 LFCFIILGVGIELCYSQCGCSQKGIKVTNFNIDDMILSEKDILRINGFKAAQAALWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMGKGCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTSTPYDFDSIM 580
            LFCFIILGVGIELCYSQCGCSQKGIKVTNFNIDDMILSEKDILRINGFKAAQAALWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMGKGCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTSTPYDFDSIM
Sbjct:    6 LFCFIILGVGIELCYSQCGCSQKGIKVTNFNIDDMILSEKDILRINGFKAAQAALWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMGKGCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTSTPYDFDSIM 198
[Close]
BLAST of Metalloendopeptidase vs. Planmine SMEST
Match: SMESG000080471.1 (SMESG000080471.1)

HSP 1 Score: 301.212 bits (770), Expect = 1.152e-104
Identity = 136/193 (70.47%), Postives = 162/193 (83.94%), Query Frame = 2 
Query:    2 LFCFIILGVGIELCYSQCGCSQKGIKVTNFNIDDMILSEKDILRINGFKAAQAALWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMGKGCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTSTPYDFDSIM 580
            +  FI L V IELC +QCGC+QKGIK++NFN+ DM+LS +D+LRINGFKAAQ   WP+K  RY FDPSYPD+NKN IRE+LKIYE ELGNCL+F E+KSDV+ATV++G GCS+++GY+KN  L ITLPD CVN+RNVKHEFTHLLGFMHEHTRPDRDQ+LKI   NV    C+NF+LCEGCK +T YDFDSIM
Sbjct:    6 IISFITLSVVIELCSAQCGCTQKGIKISNFNVGDMVLSSQDVLRINGFKAAQGVHWPNKLLRYTFDPSYPDKNKNAIREFLKIYEKELGNCLRFLEEKSDVYATVVLGGGCSANVGYNKNYPLSITLPDPCVNRRNVKHEFTHLLGFMHEHTRPDRDQFLKIEFGNVHSGLCNNFYLCEGCKLTTTYDFDSIM 198
[Close]
BLAST of Metalloendopeptidase vs. Planmine SMEST
Match: SMESG000080475.1 (SMESG000080475.1)

HSP 1 Score: 263.077 bits (671), Expect = 1.126e-89
Identity = 118/193 (61.14%), Postives = 148/193 (76.68%), Query Frame = 2 
Query:    2 LFCFIILGVGIELCYSQCGCSQKGIKVTNFNIDDMILSEKDILRINGFKAAQAALWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATVIMGKGCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTSTPYDFDSIM 580
            + CF+++ +   LCY+QCGC+QKGIK+ +FN+ DM+LS  +IL+ING+KAA    WP    RY FDPS+PD+NKN +R++LK YE ELGNC+KF E+KS V ATV+ G GCS+++GY+    L++TL D CVNKRNVKHEFTH LGF HEHTRPDRD  L I   NV    C NF+LCEGCKT+TPYDFDSIM
Sbjct:    7 VICFLLITL-FSLCYAQCGCTQKGIKIADFNVGDMVLSPVEILKINGYKAADGEKWPKNELRYTFDPSFPDKNKNPVRDFLKAYEKELGNCIKFKEEKSGVFATVVTGGGCSANVGYNSRYPLKVTLADPCVNKRNVKHEFTHSLGFQHEHTRPDRDNNLNIQFNNVKKNLCANFYLCEGCKTTTPYDFDSIM 198
[Close]
BLAST of Metalloendopeptidase vs. Planmine SMEST
Match: SMESG000072791.1 (SMESG000072791.1)

HSP 1 Score: 137.117 bits (344), Expect = 3.511e-40
Identity = 71/201 (35.32%), Postives = 109/201 (54.23%), Query Frame = 2 
Query:    2 LFCFIILGVGIELCYSQCGCSQKGI---KVTNFNIDDMILSEKDILRINGFKA--AQAALWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATV-IMGKGCSSSIGY--DKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTSTPYDFDSIM 580
            LFC +++   +     QCGC ++ +    + +  + DM+L + DI  INGFKA  +    WP+    + F P++P   K  +RE L   + +LGNC+KF E  +  +  V  + +GC S +GY    N+ L +  P    +K  VKHEF H LGFMH H R DRD ++ I  + +  ++C  F  CEGC    PY+ +S+M
Sbjct:    4 LFCLLLIVAAVSYVSGQCGCPRQKLLKRGLDSMQMGDMVLDKSDIALINGFKAHYSNTKRWPNNQVLFSFAPAFPGDKKGIVRECLVELQKDLGNCVKFSESTASHYIEVHSLNQGCYSLLGYTGGPNQPLNLQNPGCMYSKGTVKHEFIHALGFMHTHMRKDRDNHITIKWDRILTSHCSQFVKCEGCDLDGPYETNSVM 204
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BLAST of Metalloendopeptidase vs. Planmine SMEST
Match: SMESG000072804.1 (SMESG000072804.1)

HSP 1 Score: 130.183 bits (326), Expect = 2.138e-37
Identity = 72/200 (36.00%), Postives = 105/200 (52.50%), Query Frame = 2 
Query:    5 FCFIILGVGIELCYSQCGCSQKGI---KVTNFNIDDMILSEKDILRINGFKAAQ--AALWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSDVHATV-IMGKGCSSSIG--YDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHEHTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTSTPYDFDSIM 580
            F  +I+ V      SQCGC++K +      N ++ DM+LS+ DI  INGFK  Q  A  WP     + F   +P   +N +++ L   + +LGNC++F+E     H  V    KGC + IG   ++ + L +  P    +K  +KHEF H LGFMH H R DRD ++ I   N+  + C NF  CEGC     Y+  S+M
Sbjct:    4 FLILIVLVLANEVASQCGCNKKKLMTRATENLHVGDMLLSKADIAIINGFKHHQREARAWPGGKVSFAFANDFPADKRNLVKQCLNELQSDLGNCVQFFESTQGPHIAVHAQNKGCYAMIGCTGERGQFLNLQNPWCMNSKGTIKHEFIHALGFMHTHMRMDRDNFISINWRNIQSSQCFNFVKCEGCIMDGNYETRSVM 203
The following BLAST results are available for this feature:
BLAST of Metalloendopeptidase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ASTL9.048e-1930.81astacin like metalloendopeptidase [Source:HGNC Sym... [more]
TLL26.186e-1731.03tolloid like 2 [Source:HGNC Symbol;Acc:HGNC:11844][more]
TLL19.467e-1731.03tolloid like 1 [Source:HGNC Symbol;Acc:HGNC:11843][more]
TLL13.497e-1631.03tolloid like 1 [Source:HGNC Symbol;Acc:HGNC:11843][more]
TLL13.508e-1631.03tolloid like 1 [Source:HGNC Symbol;Acc:HGNC:11843][more]
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BLAST of Metalloendopeptidase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
nas-277.939e-1534.55Zinc metalloproteinase nas-27 [Source:UniProtKB/S... [more]
nas-78.758e-1529.41Zinc metalloproteinase nas-7 [Source:UniProtKB/Sw... [more]
nas-189.717e-1537.50Zinc metalloproteinase nas-18 [Source:UniProtKB/S... [more]
nas-123.994e-1428.00Zinc metalloproteinase nas-12 [Source:UniProtKB/S... [more]
nas-141.580e-1327.59Zinc metalloproteinase nas-14 [Source:UniProtKB/S... [more]
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BLAST of Metalloendopeptidase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CG118653.530e-1726.74gene:FBgn0028947 transcript:FBtr0080753[more]
CG67636.720e-1528.66gene:FBgn0039069 transcript:FBtr0084378[more]
CG67636.720e-1528.66gene:FBgn0039069 transcript:FBtr0334497[more]
CG66963.458e-1331.33gene:FBgn0030947 transcript:FBtr0074611[more]
CG76312.277e-1226.45gene:FBgn0028945 transcript:FBtr0080754[more]
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BLAST of Metalloendopeptidase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
tll12.239e-1731.03tolloid-like 1 [Source:NCBI gene;Acc:474335][more]
tll12.239e-1731.03tolloid-like 1 [Source:NCBI gene;Acc:474335][more]
tll12.239e-1731.03tolloid-like 1 [Source:NCBI gene;Acc:474335][more]
he1.24.019e-1631.82hatching enzyme 1, tandem dupliate 2 [Source:ZFIN;... [more]
he1.14.186e-1631.82hatching enzyme 1, tandem duplicate 1 [Source:ZFIN... [more]
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BLAST of Metalloendopeptidase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
asb145.813e-1727.78ankyrin repeat and SOCS box containing 14 [Source:... [more]
asb141.451e-1627.78ankyrin repeat and SOCS box containing 14 [Source:... [more]
asb144.247e-1631.25ankyrin repeat and SOCS box containing 14 [Source:... [more]
asb144.761e-1631.25ankyrin repeat and SOCS box containing 14 [Source:... [more]
golt1b4.870e-1632.33golgi transport 1B [Source:Xenbase;Acc:XB-GENE-575... [more]
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BLAST of Metalloendopeptidase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Tll25.141e-1731.03tolloid-like 2 [Source:MGI Symbol;Acc:MGI:1346044][more]
Tll25.228e-1731.03tolloid-like 2 [Source:MGI Symbol;Acc:MGI:1346044][more]
Tll12.060e-1631.03tolloid-like [Source:MGI Symbol;Acc:MGI:106923][more]
Bmp11.064e-1530.56bone morphogenetic protein 1 [Source:MGI Symbol;Ac... [more]
Astl8.208e-1527.65astacin-like metalloendopeptidase (M12 family) [So... [more]
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BLAST of Metalloendopeptidase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q6HA08|ASTL_HUMAN4.345e-1830.81Astacin-like metalloendopeptidase OS=Homo sapiens ... [more]
sp|P31579|LCE_ORYLA5.475e-1731.58Low choriolytic enzyme OS=Oryzias latipes OX=8090 ... [more]
sp|O57460|TLL1_DANRE1.690e-1631.03Dorsal-ventral patterning tolloid-like protein 1 O... [more]
sp|Q9DER7|TLL1_CHICK2.646e-1631.72Tolloid-like protein 1 OS=Gallus gallus OX=9031 GN... [more]
sp|Q9Y6L7|TLL2_HUMAN2.971e-1631.03Tolloid-like protein 2 OS=Homo sapiens OX=9606 GN=... [more]
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BLAST of Metalloendopeptidase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A060Q6Y64.142e-10170.47Metalloendopeptidase OS=Schmidtea mediterranea OX=... [more]
A0A060Q7153.502e-8661.14Metalloendopeptidase (Fragment) OS=Schmidtea medit... [more]
A0A060Q7861.263e-3635.32Metalloendopeptidase OS=Schmidtea mediterranea OX=... [more]
I1ZIC37.966e-3436.00Metalloendopeptidase OS=Schmidtea mediterranea OX=... [more]
A0A060Q7502.579e-3032.84Metalloendopeptidase OS=Schmidtea mediterranea OX=... [more]
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BLAST of Metalloendopeptidase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
c6ast13.357e-2031.61low choriolytic enzyme-like [Source:NCBI gene;Acc:... [more]
c6ast17.678e-1829.71low choriolytic enzyme-like [Source:NCBI gene;Acc:... [more]
c6ast19.445e-1829.71low choriolytic enzyme-like [Source:NCBI gene;Acc:... [more]
tll11.774e-1729.63tolloid-like 1 [Source:NCBI gene;Acc:474335][more]
tll12.081e-1731.03tolloid-like 1 [Source:NCBI gene;Acc:474335][more]
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BLAST of Metalloendopeptidase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
ENSPMAT00000007253.12.488e-1630.30pep scaffold:Pmarinus_7.0:GL476910:54360:144194:-1... [more]
ENSPMAT00000004913.12.644e-830.95pep scaffold:Pmarinus_7.0:GL478359:22377:26907:1 g... [more]
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BLAST of Metalloendopeptidase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Metalloendopeptidase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO414205.802e-2232.91Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO445688.825e-2033.56Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO424214.579e-1932.64Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO319972.523e-1841.57Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO450372.681e-1830.86Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Metalloendopeptidase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
mnep1.738e-2131.61nephrosin [Source:NCBI gene;Acc:100049315][more]
mnep1.821e-2131.61nephrosin [Source:NCBI gene;Acc:100049315][more]
lce6.109e-1831.58protease [Source:NCBI gene;Acc:100049451][more]
lce6.172e-1831.58protease [Source:NCBI gene;Acc:100049451][more]
tll11.490e-1727.37tolloid like 1 [Source:NCBI gene;Acc:101160961][more]
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BLAST of Metalloendopeptidase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000016662.18.775e-146100.00SMESG000016662.1[more]
SMESG000080471.11.152e-10470.47SMESG000080471.1[more]
SMESG000080475.11.126e-8961.14SMESG000080475.1[more]
SMESG000072791.13.511e-4035.32SMESG000072791.1[more]
SMESG000072804.12.138e-3736.00SMESG000072804.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30031555 ID=SMED30031555|Name=Metalloendopeptidase|organism=Schmidtea mediterranea sexual|type=transcript|length=580bp
TTTATTTTGTTTTATTATTCTGGGAGTCGGGATTGAACTGTGTTATTCAC
AGTGTGGATGTTCACAAAAGGGCATTAAAGTGACTAATTTCAACATTGAT
GACATGATTCTATCAGAAAAGGATATTCTTAGGATTAATGGATTTAAAGC
TGCCCAAGCCGCTCTATGGCCGGATAAAACTGCCAGATATATATTTGATC
CTTCCTATCCTGATAGAAACAAAAATAGAATTCGGGAATATCTGAAAATT
TACGAAGGTGAATTGGGAAATTGCCTTAAGTTTTACGAAGATAAAAGTGA
TGTTCATGCAACTGTTATTATGGGCAAGGGATGTTCTTCAAGTATTGGGT
ATGATAAGAACAAAGAATTAAGGATTACACTTCCTGATGTATGTGTCAAT
AAGCGAAATGTGAAGCACGAATTCACTCATTTATTAGGATTTATGCATGA
ACATACACGACCTGACCGGGATCAGTATTTGAAAATATTACTTGAAAATG
TCAGTCCAGCCTACTGCCATAATTTCTTTTTATGTGAGGGATGTAAAACC
TCAACCCCTTATGATTTTGACAGCATCATG
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protein sequence of SMED30031555-orf-1

>SMED30031555-orf-1 ID=SMED30031555-orf-1|Name=SMED30031555-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=193bp
LFCFIILGVGIELCYSQCGCSQKGIKVTNFNIDDMILSEKDILRINGFKA
AQAALWPDKTARYIFDPSYPDRNKNRIREYLKIYEGELGNCLKFYEDKSD
VHATVIMGKGCSSSIGYDKNKELRITLPDVCVNKRNVKHEFTHLLGFMHE
HTRPDRDQYLKILLENVSPAYCHNFFLCEGCKTSTPYDFDSIM
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000418head
PLANA:0000420parapharyngeal region
Vocabulary: INTERPRO
TermDefinition
IPR001506Peptidase_M12A
IPR006026Peptidase_Metallo
IPR024079MetalloPept_cat_dom_sf
Vocabulary: biological process
TermDefinition
GO:0006508proteolysis
Vocabulary: molecular function
TermDefinition
GO:0004222metalloendopeptidase activity
GO:0008270zinc ion binding
GO:0008237metallopeptidase activity
GO:0008233peptidase activity
GO:0016787hydrolase activity
GO:0046872metal ion binding
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001506Peptidase M12APRINTSPR00480ASTACINcoord: 186..193
score: 33.54
coord: 131..149
score: 41.49
coord: 150..167
score: 49.54
IPR001506Peptidase M12APFAMPF01400Astacincoord: 55..193
e-value: 1.5E-26
score: 93.2
IPR006026Peptidase, metallopeptidaseSMARTSM00235col_5coord: 52..191
e-value: 1.5E-11
score: 54.4
IPR024079Metallopeptidase, catalytic domain superfamilyGENE3DG3DSA:3.40.390.10coord: 16..193
e-value: 2.8E-36
score: 127.2
NoneNo IPR availablePANTHERPTHR10127DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAININGcoord: 33..193
NoneNo IPR availablePROSITEPS51864ASTACINcoord: 50..193
score: 28.159
NoneNo IPR availableSIGNALP_EUKSignalP-noTMSignalP-noTMcoord: 1..16
score: 0.702
NoneNo IPR availableSUPERFAMILYSSF55486Metalloproteases ("zincins"), catalytic domaincoord: 52..193