RING-type domain-containing protein

Overview


Name	RING-type domain-containing protein
Smed ID	SMED30031551
Length (bp)	1885

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of RING-type domain-containing protein (SMED30031551) t-SNE clustered cells

Violin plots show distribution of expression levels for RING-type domain-containing protein (SMED30031551) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of RING-type domain-containing protein (SMED30031551) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for RING-type domain-containing protein (SMED30031551) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30031551

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 4

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
X1 cell	SMED30031551	h1SMcG0008812	SmedASXL_017037	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
X2 cell	SMED30031551	h1SMcG0008812	SmedASXL_017037	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
muscle cell	SMED30031551	h1SMcG0008812	dd_Smed_v4_9026_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
zeta neoblast	SMED30031551	h1SMcG0008812	dd_Smed_v4_9026_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Human
Match: RNF10 (ring finger protein 10 [Source:HGNC Symbol;Acc:HGNC:10055])

HSP 1 Score: 58.151 bits (139), Expect = 4.581e-8
Identity = 35/130 (26.92%), Postives = 59/130 (45.38%), Query Frame = 2

Query:   35 NKINHRL----AFIQNRCTICVYEKYKFLRNIHD----FSWTSVSKIICFTNDSKVCSICFDKIILARMDRCGHIFCLSCILSVFDVNKSNHAPCPMCKDVEISINSLKRVEFHEQKLPIIGEPIKLSLL 400
            NK  H+      F+Q  C   V E   +  +  D     +W  V ++   +++   C IC      A++ RCGHIFC +CIL    +++   + CP+C    +    LK V   E    ++G+ I + L+
Sbjct:  169 NKWGHKPFNKELFLQANCQFVVSEDQDYTAHFADPDTLVNWDFVEQVRICSHEVPSCPICLYPPTAAKITRCGHIFCWACILHYLSLSEKTWSKCPICYS-SVHKKDLKSVVATESHQYVVGDTITMQLM 297

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Human
Match: RNF10 (ring finger protein 10 [Source:HGNC Symbol;Acc:HGNC:10055])

HSP 1 Score: 57.7658 bits (138), Expect = 4.793e-8
Identity = 35/130 (26.92%), Postives = 59/130 (45.38%), Query Frame = 2

Query:   35 NKINHRL----AFIQNRCTICVYEKYKFLRNIHD----FSWTSVSKIICFTNDSKVCSICFDKIILARMDRCGHIFCLSCILSVFDVNKSNHAPCPMCKDVEISINSLKRVEFHEQKLPIIGEPIKLSLL 400
            NK  H+      F+Q  C   V E   +  +  D     +W  V ++   +++   C IC      A++ RCGHIFC +CIL    +++   + CP+C    +    LK V   E    ++G+ I + L+
Sbjct:  169 NKWGHKPFNKELFLQANCQFVVSEDQDYTAHFADPDTLVNWDFVEQVRICSHEVPSCPICLYPPTAAKITRCGHIFCWACILHYLSLSEKTWSKCPICYS-SVHKKDLKSVVATESHQYVVGDTITMQLM 297

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Human
Match: RNF10 (ring finger protein 10 [Source:HGNC Symbol;Acc:HGNC:10055])

HSP 1 Score: 53.1434 bits (126), Expect = 2.150e-7
Identity = 26/90 (28.89%), Postives = 45/90 (50.00%), Query Frame = 2

Query:  131 WTSVSKIICFTNDSKVCSICFDKIILARMDRCGHIFCLSCILSVFDVNKSNHAPCPMCKDVEISINSLKRVEFHEQKLPIIGEPIKLSLL 400
            W  V ++   +++   C IC      A++ RCGHIFC +CIL    +++   + CP+C    +    LK V   E    ++G+ I + L+
Sbjct:    7 WDFVEQVRICSHEVPSCPICLYPPTAAKITRCGHIFCWACILHYLSLSEKTWSKCPICYS-SVHKKDLKSVVATESHQYVVGDTITMQLM 95

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Fly
Match: CG12099 (gene:FBgn0035232 transcript:FBtr0072829)

HSP 1 Score: 51.2174 bits (121), Expect = 2.579e-6
Identity = 25/92 (27.17%), Postives = 42/92 (45.65%), Query Frame = 2

Query:  131 WTSVSKIICFTNDSKVCSICFDKIILARMDRCGHIFCLSCILSVFDVNKSNHAPCPMCKDVEISINSLKRVEFHEQKLPIIGEPIKLSLLVK 406
            W+ + +I   T +   C IC    + A++ RCGH +C  C+L    ++      CP+C D  I    LK     + +   +GE I   L+ +
Sbjct:  196 WSYIEQINIQTTEELQCPICLYPPVAAKLTRCGHAYCWPCLLHYLSLSDKTWRKCPICYDA-IHAGDLKSCTIEQLRDLQVGEKITFQLMRR 286

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Fly
Match: CG12099 (gene:FBgn0035232 transcript:FBtr0072828)

HSP 1 Score: 51.2174 bits (121), Expect = 2.579e-6
Identity = 25/92 (27.17%), Postives = 42/92 (45.65%), Query Frame = 2

Query:  131 WTSVSKIICFTNDSKVCSICFDKIILARMDRCGHIFCLSCILSVFDVNKSNHAPCPMCKDVEISINSLKRVEFHEQKLPIIGEPIKLSLLVK 406
            W+ + +I   T +   C IC    + A++ RCGH +C  C+L    ++      CP+C D  I    LK     + +   +GE I   L+ +
Sbjct:  196 WSYIEQINIQTTEELQCPICLYPPVAAKLTRCGHAYCWPCLLHYLSLSDKTWRKCPICYDA-IHAGDLKSCTIEQLRDLQVGEKITFQLMRR 286

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
Match: rnf10 (ring finger protein 10 [Source:ZFIN;Acc:ZDB-GENE-030131-2969])

HSP 1 Score: 58.151 bits (139), Expect = 2.917e-8
Identity = 33/131 (25.19%), Postives = 62/131 (47.33%), Query Frame = 2

Query:   20 KYKMDNKINHRLAFIQNRCTICVYEKYKFLRNIHD----FSWTSVSKIICFTNDSKVCSICFDKIILARMDRCGHIFCLSCILSVFDVNKSNHAPCPMCKDVEISINSLKRVEFHEQKLPIIGEPIKLSLL 400
            K+   +K  ++  F+Q  C   V +   +  +  D      W  V ++  ++++   C IC    + A M RCGHI+C  C+L    +++ + + CP+C +   S + LK V   E +  + G  I + L+
Sbjct:  165 KWGHKHKPFNKELFLQANCQFVVSDDQDYQAHFTDPDTLVDWDCVQQVRIYSHEVPSCPICLYPPVAAHMTRCGHIYCWPCMLHYLSLSEKSWSKCPICYEAVHSAD-LKSVVAMETRQYVSGNSITMCLM 294

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
Match: zgc:66440 (zgc:66440 [Source:ZFIN;Acc:ZDB-GENE-040426-1640])

HSP 1 Score: 50.0618 bits (118), Expect = 3.563e-6
Identity = 25/67 (37.31%), Postives = 40/67 (59.70%), Query Frame = 2

Query:  119 HDFSWTSVSK-IICFTNDSKVCSICFDKII-LARMDRCGHIFCLSCILSVFDVNKSNHAPCPMCKDV 313
             + S  +VS+ ++C   +S VCSIC  +++    +D+CGH FC SC+   F V K+    CP+C+ V
Sbjct:   86 QEASARTVSELVVCHEEESTVCSICMGEMVEKTTLDKCGHAFCRSCLEQAFQVKKA----CPVCRLV 148

[Close]

Query:  119 HDFSWTSVSK-IICFTNDSKVCSICFDKII-LARMDRCGHIFCLSCILSVFDVNKSNHAPCPMCKDV 313
             + S  +VS+ ++C   +S VCSIC  +++    +D+CGH FC SC+   F V K+    CP+C+ V
Sbjct:   86 QEASARTVSELVVCHEEESTVCSICMGEMVEKTTLDKCGHAFCRSCLEQAFQVKKA----CPVCRLV 148

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
Match: zgc:66440 (zgc:66440 [Source:ZFIN;Acc:ZDB-GENE-040426-1640])

HSP 1 Score: 50.0618 bits (118), Expect = 5.174e-6
Identity = 25/67 (37.31%), Postives = 40/67 (59.70%), Query Frame = 2

Query:  119 HDFSWTSVSK-IICFTNDSKVCSICFDKII-LARMDRCGHIFCLSCILSVFDVNKSNHAPCPMCKDV 313
             + S  +VS+ ++C   +S VCSIC  +++    +D+CGH FC SC+   F V K+    CP+C+ V
Sbjct:  156 QEASARTVSELVVCHEEESTVCSICMGEMVEKTTLDKCGHAFCRSCLEQAFQVKKA----CPVCRLV 218

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
Match: zgc:66440 (zgc:66440 [Source:ZFIN;Acc:ZDB-GENE-040426-1640])

HSP 1 Score: 49.6766 bits (117), Expect = 6.469e-6
Identity = 22/56 (39.29%), Postives = 34/56 (60.71%), Query Frame = 2

Query:  149 IICFTNDSKVCSICFDKII-LARMDRCGHIFCLSCILSVFDVNKSNHAPCPMCKDV 313
            ++C   +S VCSIC  +++    +D+CGH FC SC+   F V K+    CP+C+ V
Sbjct:  191 VVCHEEESTVCSICMGEMVEKTTLDKCGHAFCRSCLEQAFQVKKA----CPVCRLV 242

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Match: egfl7 (EGF like domain multiple 7 [Source:Xenbase;Acc:XB-GENE-491413])

HSP 1 Score: 64.3142 bits (155), Expect = 3.969e-10
Identity = 38/131 (29.01%), Postives = 66/131 (50.38%), Query Frame = 2

Query:   20 KYKMDNKINHRLAFIQNRCTICVYEKYKFLRNIHD----FSWTSVSKIICFTNDSKVCSICFDKIILARMDRCGHIFCLSCILSVFDVNKSNHAPCPMCKDVEISINSLKRVEFHEQKLPIIGEPIKLSLL 400
            ++K  NK  ++  F+Q  C   V +   +  +  D     SW  V ++  F+++   C IC    + A++ RCGHIFC +CIL    +++ + + CP+C    I  + LK V   E  L  +G+ I + L+
Sbjct:  148 RHKWGNKPFNKELFLQANCQFVVSDDNDYSVHFADPDTLVSWDFVEQVRIFSHEVPSCPICLYPPVAAKITRCGHIFCWACILHYLSLSEKDWSRCPICYSSVIKKD-LKSVVTTETHLYSVGDKITMQLM 277

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Match: egfl7 (EGF like domain multiple 7 [Source:Xenbase;Acc:XB-GENE-491413])

HSP 1 Score: 64.3142 bits (155), Expect = 4.032e-10
Identity = 38/131 (29.01%), Postives = 66/131 (50.38%), Query Frame = 2

Query:   20 KYKMDNKINHRLAFIQNRCTICVYEKYKFLRNIHD----FSWTSVSKIICFTNDSKVCSICFDKIILARMDRCGHIFCLSCILSVFDVNKSNHAPCPMCKDVEISINSLKRVEFHEQKLPIIGEPIKLSLL 400
            ++K  NK  ++  F+Q  C   V +   +  +  D     SW  V ++  F+++   C IC    + A++ RCGHIFC +CIL    +++ + + CP+C    I  + LK V   E  L  +G+ I + L+
Sbjct:  148 RHKWGNKPFNKELFLQANCQFVVSDDNDYSVHFADPDTLVSWDFVEQVRIFSHEVPSCPICLYPPVAAKITRCGHIFCWACILHYLSLSEKDWSRCPICYSSVIKKD-LKSVVTTETHLYSVGDKITMQLM 277

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Mouse
Match: Rnf10 (ring finger protein 10 [Source:MGI Symbol;Acc:MGI:1859162])

HSP 1 Score: 58.151 bits (139), Expect = 2.347e-8
Identity = 35/134 (26.12%), Postives = 60/134 (44.78%), Query Frame = 2

Query:   23 YKMDNKINHRL----AFIQNRCTICVYEKYKFLRNIHD----FSWTSVSKIICFTNDSKVCSICFDKIILARMDRCGHIFCLSCILSVFDVNKSNHAPCPMCKDVEISINSLKRVEFHEQKLPIIGEPIKLSLL 400
            +   NK  H+      F+Q  C   V E   +  +  D     +W  V ++   +++   C IC      A++ RCGHIFC +CIL    +++   + CP+C    +    LK V   E +   +G+ I + L+
Sbjct:  128 WGKRNKWGHKPFNKELFLQANCQFVVSEDQDYAAHFADPDTLVNWDFVEQVRICSHEVPSCPICLYPPTAAKITRCGHIFCWACILHYLSLSEKTWSKCPICYS-SVHKKDLKSVVATESRQYAVGDTITMQLM 260

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Mouse
Match: Rnf10 (ring finger protein 10 [Source:MGI Symbol;Acc:MGI:1859162])

HSP 1 Score: 58.151 bits (139), Expect = 2.802e-8
Identity = 35/130 (26.92%), Postives = 59/130 (45.38%), Query Frame = 2

Query:   35 NKINHRL----AFIQNRCTICVYEKYKFLRNIHD----FSWTSVSKIICFTNDSKVCSICFDKIILARMDRCGHIFCLSCILSVFDVNKSNHAPCPMCKDVEISINSLKRVEFHEQKLPIIGEPIKLSLL 400
            NK  H+      F+Q  C   V E   +  +  D     +W  V ++   +++   C IC      A++ RCGHIFC +CIL    +++   + CP+C    +    LK V   E +   +G+ I + L+
Sbjct:  169 NKWGHKPFNKELFLQANCQFVVSEDQDYAAHFADPDTLVNWDFVEQVRICSHEVPSCPICLYPPTAAKITRCGHIFCWACILHYLSLSEKTWSKCPICYS-SVHKKDLKSVVATESRQYAVGDTITMQLM 297

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Mouse
Match: Rnf10 (ring finger protein 10 [Source:MGI Symbol;Acc:MGI:1859162])

HSP 1 Score: 58.151 bits (139), Expect = 2.852e-8
Identity = 35/130 (26.92%), Postives = 59/130 (45.38%), Query Frame = 2

Query:   35 NKINHRL----AFIQNRCTICVYEKYKFLRNIHD----FSWTSVSKIICFTNDSKVCSICFDKIILARMDRCGHIFCLSCILSVFDVNKSNHAPCPMCKDVEISINSLKRVEFHEQKLPIIGEPIKLSLL 400
            NK  H+      F+Q  C   V E   +  +  D     +W  V ++   +++   C IC      A++ RCGHIFC +CIL    +++   + CP+C    +    LK V   E +   +G+ I + L+
Sbjct:  169 NKWGHKPFNKELFLQANCQFVVSEDQDYAAHFADPDTLVNWDFVEQVRICSHEVPSCPICLYPPTAAKITRCGHIFCWACILHYLSLSEKTWSKCPICYS-SVHKKDLKSVVATESRQYAVGDTITMQLM 297

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Mouse
Match: Rnf10 (ring finger protein 10 [Source:MGI Symbol;Acc:MGI:1859162])

HSP 1 Score: 58.151 bits (139), Expect = 2.903e-8
Identity = 35/130 (26.92%), Postives = 59/130 (45.38%), Query Frame = 2

Query:   35 NKINHRL----AFIQNRCTICVYEKYKFLRNIHD----FSWTSVSKIICFTNDSKVCSICFDKIILARMDRCGHIFCLSCILSVFDVNKSNHAPCPMCKDVEISINSLKRVEFHEQKLPIIGEPIKLSLL 400
            NK  H+      F+Q  C   V E   +  +  D     +W  V ++   +++   C IC      A++ RCGHIFC +CIL    +++   + CP+C    +    LK V   E +   +G+ I + L+
Sbjct:  169 NKWGHKPFNKELFLQANCQFVVSEDQDYAAHFADPDTLVNWDFVEQVRICSHEVPSCPICLYPPTAAKITRCGHIFCWACILHYLSLSEKTWSKCPICYS-SVHKKDLKSVVATESRQYAVGDTITMQLM 297

[Close]

BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q32NQ8|RNF10_XENLA (RING finger protein 10 OS=Xenopus laevis OX=8355 GN=rnf10 PE=2 SV=1)

HSP 1 Score: 62.3882 bits (150), Expect = 1.027e-8
Identity = 38/131 (29.01%), Postives = 65/131 (49.62%), Query Frame = 2

Query:   20 KYKMDNKINHRLAFIQNRCTICVYEKYKFLRNIHD----FSWTSVSKIICFTNDSKVCSICFDKIILARMDRCGHIFCLSCILSVFDVNKSNHAPCPMCKDVEISINSLKRVEFHEQKLPIIGEPIKLSLL 400
            ++K  NK  ++  F+Q  C   V +   +  +  D     SW  V ++  F+++   C IC    + A++ RCGHIFC  CIL    +++ + + CP+C    I  + LK V   E  L  +G+ I + L+
Sbjct:  149 RHKWANKPFNKELFLQANCQFVVSDVNDYSVHFTDPDTLVSWDFVEQVRIFSHEVASCPICLYPPVAAKITRCGHIFCWPCILHYLSLSEKDWSRCPICYSSIIKKD-LKSVVATETHLYSVGDKITMQLM 278

[Close]

BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q5XI59|RNF10_RAT (RING finger protein 10 OS=Rattus norvegicus OX=10116 GN=Rnf10 PE=2 SV=1)

HSP 1 Score: 60.8474 bits (146), Expect = 2.786e-8
Identity = 36/130 (27.69%), Postives = 60/130 (46.15%), Query Frame = 2

Query:   35 NKINHRL----AFIQNRCTICVYEKYKFLRNIHD----FSWTSVSKIICFTNDSKVCSICFDKIILARMDRCGHIFCLSCILSVFDVNKSNHAPCPMCKDVEISINSLKRVEFHEQKLPIIGEPIKLSLL 400
            NK  H+      F+Q  C   V E   +  N  D     +W  V ++   +++   C IC      A++ RCGHIFC +CIL    +++   + CP+C    +    LK V   E +  ++G+ I + L+
Sbjct:  169 NKWGHKPFNKELFLQANCQFVVSEDQDYTANFADPDTLVNWDFVEQVRICSHEVPSCPICLYPPTAAKITRCGHIFCWACILHYLSLSERTWSKCPICYS-SVHKKDLKSVVATESRQYVVGDTITMQLM 297

[Close]

BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q08E13|RNF10_BOVIN (RING finger protein 10 OS=Bos taurus OX=9913 GN=RNF10 PE=2 SV=1)

HSP 1 Score: 58.151 bits (139), Expect = 1.744e-7
Identity = 35/130 (26.92%), Postives = 60/130 (46.15%), Query Frame = 2

Query:   35 NKINHRL----AFIQNRCTICVYEKYKFLRNIHD----FSWTSVSKIICFTNDSKVCSICFDKIILARMDRCGHIFCLSCILSVFDVNKSNHAPCPMCKDVEISINSLKRVEFHEQKLPIIGEPIKLSLL 400
            NK  H+      F+Q  C   V E   +  +  D     +W  V ++   +++   C IC      A++ RCGHIFC +CIL    +++   + CP+C    +    LK V   E +  ++G+ I + L+
Sbjct:  169 NKWGHKPFNKELFLQANCQFVVSEDQDYTVHFADPDTLVNWDFVEQVRICSHEVPSCPICLYPPTAAKITRCGHIFCWACILHYLSLSEKTWSKCPICYS-SVHKKDLKSVVATESRQYVVGDTITMQLM 297

[Close]

BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q3UIW5|RNF10_MOUSE (RING finger protein 10 OS=Mus musculus OX=10090 GN=Rnf10 PE=2 SV=2)

HSP 1 Score: 58.151 bits (139), Expect = 1.995e-7
Identity = 35/130 (26.92%), Postives = 59/130 (45.38%), Query Frame = 2

Query:   35 NKINHRL----AFIQNRCTICVYEKYKFLRNIHD----FSWTSVSKIICFTNDSKVCSICFDKIILARMDRCGHIFCLSCILSVFDVNKSNHAPCPMCKDVEISINSLKRVEFHEQKLPIIGEPIKLSLL 400
            NK  H+      F+Q  C   V E   +  +  D     +W  V ++   +++   C IC      A++ RCGHIFC +CIL    +++   + CP+C    +    LK V   E +   +G+ I + L+
Sbjct:  169 NKWGHKPFNKELFLQANCQFVVSEDQDYAAHFADPDTLVNWDFVEQVRICSHEVPSCPICLYPPTAAKITRCGHIFCWACILHYLSLSEKTWSKCPICYS-SVHKKDLKSVVATESRQYAVGDTITMQLM 297

[Close]

BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q8N5U6|RNF10_HUMAN (RING finger protein 10 OS=Homo sapiens OX=9606 GN=RNF10 PE=1 SV=2)

HSP 1 Score: 58.151 bits (139), Expect = 2.200e-7
Identity = 35/130 (26.92%), Postives = 59/130 (45.38%), Query Frame = 2

Query:   35 NKINHRL----AFIQNRCTICVYEKYKFLRNIHD----FSWTSVSKIICFTNDSKVCSICFDKIILARMDRCGHIFCLSCILSVFDVNKSNHAPCPMCKDVEISINSLKRVEFHEQKLPIIGEPIKLSLL 400
            NK  H+      F+Q  C   V E   +  +  D     +W  V ++   +++   C IC      A++ RCGHIFC +CIL    +++   + CP+C    +    LK V   E    ++G+ I + L+
Sbjct:  169 NKWGHKPFNKELFLQANCQFVVSEDQDYTAHFADPDTLVNWDFVEQVRICSHEVPSCPICLYPPTAAKITRCGHIFCWACILHYLSLSEKTWSKCPICYS-SVHKKDLKSVVATESHQYVVGDTITMQLM 297

[Close]

BLAST of RING-type domain-containing protein vs. TrEMBL
Match: A0A0R3WNE4 (RING-type domain-containing protein OS=Hydatigena taeniaeformis OX=6205 GN=TTAC_LOCUS2271 PE=4 SV=1)

HSP 1 Score: 73.1738 bits (178), Expect = 1.146e-9
Identity = 70/324 (21.60%), Postives = 143/324 (44.14%), Query Frame = 2

Query:  131 WTSVSKIICFTNDSKVCSICFDKIILARMDRCGHIFCLSCILSVFDV-NKSNHAPCPMCKDVEISINSLKRVEFHEQKLPIIGEPIKLSLLVKGQQNVCPRFAHFLTSYKDYNLPKLENSISKFLS-IVTEKDFRSQQDIIDDLNXXXXXXXXXXXXXXFPRXXXXXXXXXXXXXXXHFQDEIKVINKNEIDENCEIFEDNFNLIEYKNMKEKFELFYQAEGYRFVFLDQLNQKQILDKSQHTWKVVPVQIKSTIREIREEFVDNEFLMRTK-LSHLFRGVKVTIVTIDLPNALLEPIT---GGNLRILRSHQEQIYKARKEDL 1084
            W+ V  + C+  +  VC IC +  IL RM  CGH++C  C+       N ++   C +C  V++  N L+RV      +P +G+ ++L L+ + ++++ P  A  +    + +  +  N  S+FLS +V  K    Q+DI+  ++     +K     ++    + E+ L+  +   K       V  K  ++E      D  + +      E +  +YQ      ++L  +N + +++        +P +IK  + E+    + +    R + L HL  G    ++ I   N ++   T     ++  +R H+ +  +AR+  L
Sbjct:  113 WSDVLVVGCYQTEESVCPICLEAPILPRMGPCGHVYCYLCVSCYISFENDTSSKQCAVC-GVQLRTNDLRRVRLFSSHVPNVGDTVRLDLMRRHKRSIFPMVASEVQGRLEGS-GREANPASRFLSRLVVAK----QEDIVGLVDTDIATMKAFLAEDQLEEADEERFLIAKRILRK------LVAEKRSMEEATVFTRDEVSFVSNDTTAEDYFFYYQEVSGHDIYLHSINWRCLVE--DFGVSNLPQEIKGKVVEVETYTMSSALRSRYRHLRHLPLGRTFHLIEIQFENPIISAETLLLVSDVLTMRQHRREQKEARERSL 422

[Close]

BLAST of RING-type domain-containing protein vs. TrEMBL
Match: A0A0K2TF82 (CG12099 CG12099PBlike [Tribolium castaneum] (Fragment) OS=Lepeophtheirus salmonis OX=72036 PE=4 SV=1)

HSP 1 Score: 72.4034 bits (176), Expect = 1.580e-9
Identity = 41/136 (30.15%), Postives = 65/136 (47.79%), Query Frame = 2

Query:   59 FIQNRCTICVYEKYKFLRNIHD----FSWTSVSKIICFTNDSKVCSICFDKIILARMDRCGHIFCLSCILSVFDVNKSNHAPCPMCKDVEISINSLKRVEFHEQKLPIIGEPIKLSLLVKGQQNVCPRFAHFLTSY 454
            ++Q  C   V     +  +I+D      W ++ ++   TND   C IC  +  +A+M RCGHI+C  CIL    ++  N   CP+C D  +    LK V         IG+ I+L+L+   ++N    FA+  T Y
Sbjct:   45 YLQANCQFLVKNNRDYSEHINDPDLPLDWEAIERVTLRTNDHPSCPICLYQPKVAKMTRCGHIYCWQCILHYLALSDDNWRKCPIC-DESVYKEDLKSVVTEPFSEHTIGDEIELNLM---RRNRTSMFAYLTTKY 176

[Close]

BLAST of RING-type domain-containing protein vs. TrEMBL
Match: A0A0K2TF84 (CG12099 CG12099PBlike [Tribolium castaneum] OS=Lepeophtheirus salmonis OX=72036 PE=4 SV=1)

HSP 1 Score: 72.0182 bits (175), Expect = 2.328e-9
Identity = 41/136 (30.15%), Postives = 65/136 (47.79%), Query Frame = 2

Query:   59 FIQNRCTICVYEKYKFLRNIHD----FSWTSVSKIICFTNDSKVCSICFDKIILARMDRCGHIFCLSCILSVFDVNKSNHAPCPMCKDVEISINSLKRVEFHEQKLPIIGEPIKLSLLVKGQQNVCPRFAHFLTSY 454
            ++Q  C   V     +  +I+D      W ++ ++   TND   C IC  +  +A+M RCGHI+C  CIL    ++  N   CP+C D  +    LK V         IG+ I+L+L+   ++N    FA+  T Y
Sbjct:  159 YLQANCQFLVKNNRDYSEHINDPDLPLDWEAIERVTLRTNDHPSCPICLYQPKVAKMTRCGHIYCWQCILHYLALSDDNWRKCPIC-DESVYKEDLKSVVTEPFSEHTIGDEIELNLM---RRNRTSMFAYLTTKY 290

[Close]

BLAST of RING-type domain-containing protein vs. TrEMBL
Match: E9H0B1 (RING-type domain-containing protein OS=Daphnia pulex OX=6669 GN=DAPPUDRAFT_306980 PE=4 SV=1)

HSP 1 Score: 71.633 bits (174), Expect = 3.674e-9
Identity = 36/128 (28.12%), Postives = 64/128 (50.00%), Query Frame = 2

Query:   59 FIQNRCTICVYEKYKFLRNIHD----FSWTSVSKIICFTNDSKVCSICFDKIILARMDRCGHIFCLSCILSVFDVNKSNHAPCPMCKDVEISINSLKRVEFHEQKLPIIGEPIKLSLLVKGQQNVCPR 430
            ++Q  C   V     +   + D      W S+ +I  + ++   C IC    + A+M RCGHI+C  CIL    ++     PCP+C DV + I  LK V   EQ+   +G+ +++ L+ + + ++ P+
Sbjct:  166 YLQANCQFVVKADGDYTVYLADPDLLVPWESIEQIRIWGSEVGSCPICLHPPVAAKMTRCGHIYCWPCILHFLALSDKPSRPCPIC-DVSVRIQDLKSVVALEQRNLKVGDALEMRLMKRDRHSLQPQ 292

[Close]

BLAST of RING-type domain-containing protein vs. TrEMBL
Match: A0A210PUY3 (RING finger protein 10 OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT16827 PE=4 SV=1)

HSP 1 Score: 71.633 bits (174), Expect = 3.883e-9
Identity = 46/158 (29.11%), Postives = 74/158 (46.84%), Query Frame = 2

Query:   59 FIQNRCTICVYEKYKFLRNIHD----FSWTSVSKIICFTNDSKVCSICFDKIILARMDRCGHIFCLSCILSVFDVNKSNHAPCPMCKDV--EISINSLKRVEFHEQKLPIIGEPIKLSLLVKGQQNVCPRFAHFLTSYKDYNLPKL--ENSISKFLSI 508
            F+Q  C   V +K  +  + H+      W SV  I   ++++  C IC    + A+M RCGHI+C +CIL    + +     CP+C +   +  + S++  E H+ K   +GE I L L+ + + NV             Y LPK    N + KF S+
Sbjct:  137 FLQANCQFVVDQKGDYTIHNHNPDTLVDWDSVELIRVQSSETSSCPICLQAPVAAKMTRCGHIYCWACILHYLALGEKTWRKCPICYESIHDKDLRSVESKEVHQYK---VGETITLQLMKRQKGNV-------------YALPKSCEANKLGKFFSV 278

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
Match: rnf10 (ring finger protein 10 [Source:ZFIN;Acc:ZDB-GENE-030131-2969])

HSP 1 Score: 60.8474 bits (146), Expect = 2.891e-9
Identity = 34/131 (25.95%), Postives = 64/131 (48.85%), Query Frame = 2

Query:   20 KYKMDNKINHRLAFIQNRCTICVYEKYKFLRNIHD----FSWTSVSKIICFTNDSKVCSICFDKIILARMDRCGHIFCLSCILSVFDVNKSNHAPCPMCKDVEISINSLKRVEFHEQKLPIIGEPIKLSLL 400
            K+   +K  ++  F+Q  C   V +   +  +  D     SW SV ++  ++++   C IC    + A + RCGHI+C  C+L    +++ + + CP+C +   S + LK V   E    + G+ I + L+
Sbjct:  169 KWGHKHKPFNKELFLQANCQFVVIDDQDYQAHFTDPDTLVSWDSVQQVRIYSHEVPTCPICLYPPVAAHITRCGHIYCWPCMLHYLSLSEKSWSKCPICYEAVHSAD-LKSVVAMETHQYVPGDVITMRLM 298

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Yeast
Match: MAG2 (Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1 [Source:SGD;Acc:S000004419])

HSP 1 Score: 46.9802 bits (110), Expect = 8.176e-6
Identity = 30/103 (29.13%), Postives = 47/103 (45.63%), Query Frame = 2

Query:  179 CSICF-DKIILARMDRCGHIFCLSCILSVFDV------------NKSNHAPCPMCKDVEISINSLKRVEFHE-------QKLPIIGEPIKLSLLVKGQQNVCP 427
            CSIC  ++ +  RM  CGHIFCLSC+L+ F +             K  +  CP+C  + I    +K V + +        + P  G  + L L+ K   ++ P
Sbjct:  195 CSICLSEEPVAPRMVTCGHIFCLSCLLNFFSIEETVKNKETGYSKKKKYKECPLCGSI-IGPKRVKPVLYEDDFDVTRLNQKPEPGATVHLQLMCKPHGSLLP 296

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Medaka
Match: rnf10 (ring finger protein 10 [Source:NCBI gene;Acc:101166478])

HSP 1 Score: 62.003 bits (149), Expect = 1.450e-9
Identity = 34/131 (25.95%), Postives = 63/131 (48.09%), Query Frame = 2

Query:   20 KYKMDNKINHRLAFIQNRCTICVYEKYKFLRNIHD----FSWTSVSKIICFTNDSKVCSICFDKIILARMDRCGHIFCLSCILSVFDVNKSNHAPCPMCKDVEISINSLKRVEFHEQKLPIIGEPIKLSLL 400
            K+   NK  ++  F+Q  C   V +   +  +  D     +W  V ++   +++   C IC    + AR+ RCGHIFC  C+L    ++  + + CP+C +  +    LK V   E +  ++G+ I + L+
Sbjct:  165 KWGHKNKPFNKELFLQANCQFVVSDDQDYKAHFTDPDTLVNWDCVQQVRIHSHEVPSCPICLYPPVAARITRCGHIFCWPCMLHYLSLSDKSWSKCPICYEA-VHTADLKSVVAMETRQYVVGDVITMRLM 294

[Close]

BLAST of RING-type domain-containing protein vs. Planmine SMEST
Match: SMESG000076269.1 (SMESG000076269.1)

HSP 1 Score: 900.582 bits (2326), Expect = 0.000e+0
Identity = 527/536 (98.32%), Postives = 528/536 (98.51%), Query Frame = 2

Query:   29 MDNKINHRLAFIQNRCTICVYEKYKFLRNIHDFSWTSVSKIICFTNDSKVCSICFDKIILARMDRCGHIFCLSCILSVFDVNKSNHAPCPMCKDVEISINSLKRVEFHEQKLPIIGEPIKLSLLVKGQQNVCPRFAHFLTSYKDYNLPKLENSISKFLSIVTEKDFRSQQDIIDDLNXXXXXXXXXXXXXXFPRXXXXXXXXXXXXXXXHFQDEIKVINKNEIDENCEIFEDNFNLIEYKNMKEKFELFYQAEGYRFVFLDQLNQKQILDKSQHTWKVVPVQIKSTIREIREEFVDNEFLMRTKLSHLFRGVKVTIVTIDLPNALLEPITGGNLRILRSHQEQIYKARKEDLDMXXXXXXXXXXXXSLPPRQRVLTTVNTENAQYSRLFDMIAEGFNTCTLGIECLVPDDDYPHAQDCEHYASAKHHLSPLETAPTDEKFLGILRMKLNVFHP-XXXXXXXNEALQPAVVTQCXXXXXXXXXXXXXXXXERLSSDELSLIKEANRIAPYIVPRKPXXXXXXXXXXXXXXXXMKAAS 1633
            MDNKINHRLAFIQNRCTICVYEKYKFLRNIHDFSWTSVSKIICFTNDSKVCSICFDKIILARMDRCGHIFCLSCILSVFDVNKSNHAPCPMCKDVEISINSLKRVEFHEQKLPIIGEPIKLSLLVKGQQNVCPRFAHFLTSYKDYNLPKLENSISKFLSIVTEKDFRSQQDIIDDLNLIKCKLKQKSKLNKFPRNNLEKLLLNLKSELKHFQDEIKVINKNEIDENCEIFEDNFNLIEYKNMKEKFELFYQAEGYRFVFLDQLNQKQILDKSQ TWKVVPVQIKSTIREIREEFVDNEF+MRTKLSHLFRGVKVTIVTIDLPNALLEPITGGNLRILRSHQEQIYKARKEDLDMRERIAKRAAERRSLPPRQRVLTTVNTENAQYSRLFDMIAEGFNTCTLGIECLVPDDDYPHAQDCEHYASAKHHLSPLETAPTDEKFLGILRMKLNVFHP  AAAAADNEALQPAVVTQCPSPAAA V  LLHAPPERLS DELSLIKEANRIAPYIVPRK KSQNQQKKLRKLQKQSMKAAS
Sbjct:    1 MDNKINHRLAFIQNRCTICVYEKYKFLRNIHDFSWTSVSKIICFTNDSKVCSICFDKIILARMDRCGHIFCLSCILSVFDVNKSNHAPCPMCKDVEISINSLKRVEFHEQKLPIIGEPIKLSLLVKGQQNVCPRFAHFLTSYKDYNLPKLENSISKFLSIVTEKDFRSQQDIIDDLNLIKCKLKQKSKLNKFPRNNLEKLLLNLKSELKHFQDEIKVINKNEIDENCEIFEDNFNLIEYKNMKEKFELFYQAEGYRFVFLDQLNQKQILDKSQQTWKVVPVQIKSTIREIREEFVDNEFVMRTKLSHLFRGVKVTIVTIDLPNALLEPITGGNLRILRSHQEQIYKARKEDLDMRERIAKRAAERRSLPPRQRVLTTVNTENAQYSRLFDMIAEGFNTCTLGIECLVPDDDYPHAQDCEHYASAKHHLSPLETAPTDEKFLGILRMKLNVFHPDAAAAAADNEALQPAVVTQCPSPAAAVVPLLLHAPPERLSLDELSLIKEANRIAPYIVPRKLKSQNQQKKLRKLQKQSMKAAS 536

[Close]

BLAST of RING-type domain-containing protein vs. Planmine SMEST
Match: SMESG000016827.1 (SMESG000016827.1)

HSP 1 Score: 58.151 bits (139), Expect = 1.396e-8
Identity = 31/114 (27.19%), Postives = 57/114 (50.00%), Query Frame = 2

Query:  101 KFLRNIHDFS-----WTSVSKIICFTNDSKVCSICFDKIILARMDRCGHIFCLSCILSVFDVNKSNHAPCPMCKDVEISINSLKRVEFHEQKLPIIGEPIKLSLLVKGQQNVCP 427
            K L++ +DF      W S+ +I  +  +  +C IC D   ++R D+CGH++C  C+          +  C +C + EI +  +KR  F E+    +G+ I L L+ + + +  P
Sbjct:   83 KCLKSEYDFDDIYSQWDSIIQINFYKTEDIMCPICMDAPKVSRTDKCGHVYCFPCLNKFLSYENGYYKKCALC-NQEIDLKRVKRAAFIERFSLNVGDNISLLLMRRSKSDSFP 195

The following BLAST results are available for this feature:

BLAST of RING-type domain-containing protein vs. Ensembl Human
BLAST of RING-type domain-containing protein vs. Ensembl Celegans
BLAST of RING-type domain-containing protein vs. Ensembl Fly
BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
BLAST of RING-type domain-containing protein vs. Ensembl Mouse
BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
BLAST of RING-type domain-containing protein vs. TrEMBL
BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
BLAST of RING-type domain-containing protein vs. Ensembl Sea Lamprey
BLAST of RING-type domain-containing protein vs. Ensembl Yeast
BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
BLAST of RING-type domain-containing protein vs. Ensembl Medaka
BLAST of RING-type domain-containing protein vs. Planmine SMEST

BLAST of RING-type domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 3


Match Name	E-value	Identity	Description
RNF10	4.581e-8	26.92	ring finger protein 10 [Source:HGNC Symbol;Acc:HGN...	[more]
RNF10	4.793e-8	26.92	ring finger protein 10 [Source:HGNC Symbol;Acc:HGN...	[more]
RNF10	2.150e-7	28.89	ring finger protein 10 [Source:HGNC Symbol;Acc:HGN...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of RING-type domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2


Match Name	E-value	Identity	Description
CG12099	2.579e-6	27.17	gene:FBgn0035232 transcript:FBtr0072829	[more]
CG12099	2.579e-6	27.17	gene:FBgn0035232 transcript:FBtr0072828	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
rnf10	2.917e-8	25.19	ring finger protein 10 [Source:ZFIN;Acc:ZDB-GENE-0...	[more]
zgc:66440	3.563e-6	37.31	zgc:66440 [Source:ZFIN;Acc:ZDB-GENE-040426-1640]	[more]
zgc:66440	3.563e-6	37.31	zgc:66440 [Source:ZFIN;Acc:ZDB-GENE-040426-1640]	[more]
zgc:66440	5.174e-6	37.31	zgc:66440 [Source:ZFIN;Acc:ZDB-GENE-040426-1640]	[more]
zgc:66440	6.469e-6	39.29	zgc:66440 [Source:ZFIN;Acc:ZDB-GENE-040426-1640]	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2


Match Name	E-value	Identity	Description
egfl7	3.969e-10	29.01	EGF like domain multiple 7 [Source:Xenbase;Acc:XB-...	[more]
egfl7	4.032e-10	29.01	EGF like domain multiple 7 [Source:Xenbase;Acc:XB-...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 4


Match Name	E-value	Identity	Description
Rnf10	2.347e-8	26.12	ring finger protein 10 [Source:MGI Symbol;Acc:MGI:...	[more]
Rnf10	2.802e-8	26.92	ring finger protein 10 [Source:MGI Symbol;Acc:MGI:...	[more]
Rnf10	2.852e-8	26.92	ring finger protein 10 [Source:MGI Symbol;Acc:MGI:...	[more]
Rnf10	2.903e-8	26.92	ring finger protein 10 [Source:MGI Symbol;Acc:MGI:...	[more]

BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q32NQ8\|RNF10_XENLA	1.027e-8	29.01	RING finger protein 10 OS=Xenopus laevis OX=8355 G...	[more]
sp\|Q5XI59\|RNF10_RAT	2.786e-8	27.69	RING finger protein 10 OS=Rattus norvegicus OX=101...	[more]
sp\|Q08E13\|RNF10_BOVIN	1.744e-7	26.92	RING finger protein 10 OS=Bos taurus OX=9913 GN=RN...	[more]
sp\|Q3UIW5\|RNF10_MOUSE	1.995e-7	26.92	RING finger protein 10 OS=Mus musculus OX=10090 GN...	[more]
sp\|Q8N5U6\|RNF10_HUMAN	2.200e-7	26.92	RING finger protein 10 OS=Homo sapiens OX=9606 GN=...	[more]

BLAST of RING-type domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A0R3WNE4	1.146e-9	21.60	RING-type domain-containing protein OS=Hydatigena ...	[more]
A0A0K2TF82	1.580e-9	30.15	CG12099 CG12099PBlike [Tribolium castaneum] (Fragm...	[more]
A0A0K2TF84	2.328e-9	30.15	CG12099 CG12099PBlike [Tribolium castaneum] OS=Lep...	[more]
E9H0B1	3.674e-9	28.13	RING-type domain-containing protein OS=Daphnia pul...	[more]
A0A210PUY3	3.883e-9	29.11	RING finger protein 10 OS=Mizuhopecten yessoensis ...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1


Match Name	E-value	Identity	Description
rnf10	2.891e-9	25.95	ring finger protein 10 [Source:ZFIN;Acc:ZDB-GENE-0...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of RING-type domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1


Match Name	E-value	Identity	Description
MAG2	8.176e-6	29.13	Cytoplasmic protein of unknown function; induced i...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of RING-type domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1


Match Name	E-value	Identity	Description
rnf10	1.450e-9	25.95	ring finger protein 10 [Source:NCBI gene;Acc:10116...	[more]

BLAST of RING-type domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2


Match Name	E-value	Identity	Description
SMESG000076269.1	0.000e+0	98.32	SMESG000076269.1	[more]
SMESG000016827.1	1.396e-8	27.19	SMESG000016827.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30031551 ID=SMED30031551|Name=RING-type domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1885bp
TACTTTTTAAAATATAATAAAATACAAAATGGATAATAAAATAAATCATA
GGCTTGCTTTCATTCAAAATAGATGTACAATATGCGTTTACGAAAAGTAC
AAGTTCTTACGAAATATTCATGATTTTTCATGGACCAGTGTATCTAAAAT
TATCTGCTTTACTAATGATTCCAAAGTTTGTTCAATATGTTTCGATAAAA
TAATATTAGCACGCATGGATCGATGTGGTCACATATTTTGCCTGTCTTGT
ATTTTAAGTGTTTTTGATGTCAACAAATCAAACCATGCGCCATGTCCAAT
GTGTAAAGATGTAGAAATCAGTATCAATTCCTTAAAACGTGTCGAGTTCC
ATGAACAGAAATTACCAATAATAGGCGAGCCTATTAAACTAAGTTTATTA
GTTAAAGGCCAACAAAATGTTTGTCCAAGATTTGCACACTTTTTAACTAG
TTATAAAGATTACAATTTACCGAAGCTTGAAAACTCGATTAGCAAATTTC
TCAGTATTGTAACTGAAAAAGATTTTCGTTCTCAGCAAGATATTATCGAT
GATCTCAATCTTATTAAATGTAAATTAAAACAGAAATCAAAATTAAACAA
ATTTCCACGAAATAATCTCGAGAAATTATTGCTGAATTTAAAAAGTGAAC
TCAAACATTTTCAAGACGAAATTAAAGTGATAAACAAAAATGAAATAGAT
GAAAATTGTGAGATTTTCGAGGATAATTTTAATTTAATTGAATATAAAAA
TATGAAAGAAAAATTCGAATTGTTCTACCAAGCCGAAGGATATCGATTTG
TGTTTCTCGATCAATTGAACCAGAAACAAATACTCGACAAGTCGCAACAT
ACTTGGAAAGTTGTGCCGGTTCAAATAAAATCCACAATCAGAGAAATTCG
GGAAGAATTTGTCGACAATGAGTTTCTAATGCGCACAAAACTGTCGCATC
TGTTCAGGGGAGTCAAAGTGACAATTGTGACAATCGATCTACCGAACGCA
TTGCTGGAACCAATAACGGGTGGAAATCTGAGGATTTTGCGCTCTCATCA
GGAACAGATTTACAAAGCCCGAAAGGAGGATTTGGACATGCGGGAAAGGA
TTGCTAAACGAGCTGCTGAACGAAGGAGTTTACCACCACGGCAACGAGTC
TTAACAACAGTAAATACCGAGAATGCTCAATATTCGCGACTATTCGACAT
GATTGCTGAGGGCTTCAACACTTGCACGCTGGGTATTGAGTGCCTGGTGC
CAGATGATGATTATCCCCATGCACAAGATTGCGAGCATTACGCCAGTGCA
AAGCACCATTTATCACCGTTGGAAACTGCTCCAACAGATGAGAAATTCCT
CGGCATATTGCGGATGAAGCTGAACGTATTCCACCCGGATGCTGCTGCTG
CTGCTGATAATGAGGCACTGCAGCCGGCTGTCGTCACCCAATGCCCGTCT
CCAGCAGCAGCAGCAGTTGTCCCCCTCCTCCATGCCCCTCCAGAACGGTT
GTCATCGGATGAGCTGTCACTCATTAAAGAGGCAAACCGTATTGCGCCAT
ATATCGTTCCCAGGAAACCGAAATCTCAGAACCAGCAAAAGAAACTGAGA
AAACTCCAGAAACAATCAATGAAGGCCGCCAGTTGATATTATGGAAATTA
TATTTTTACTTGAGTTATATATTTACAATTGGAAATTTTATGGCGGTTTT
AGAATTAGATGTCTTAATATTTGCATTTTGATCCGATCTGAGCAGTTTGA
TCCGATCGGGCATTTTGATCCGATTGAGCATTTATTGTTGGGTTTTATTT
TATTATTTTGTGTATGTGTGTGTGTCAGTACATTCTAGATATCGACTTCT
CTTATTGGTTATTACTATTGATTCGTTATTATTAG

protein sequence of SMED30031551-orf-1

>SMED30031551-orf-1 ID=SMED30031551-orf-1|Name=SMED30031551-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=536bp
MDNKINHRLAFIQNRCTICVYEKYKFLRNIHDFSWTSVSKIICFTNDSKV
CSICFDKIILARMDRCGHIFCLSCILSVFDVNKSNHAPCPMCKDVEISIN
SLKRVEFHEQKLPIIGEPIKLSLLVKGQQNVCPRFAHFLTSYKDYNLPKL
ENSISKFLSIVTEKDFRSQQDIIDDLNLIKCKLKQKSKLNKFPRNNLEKL
LLNLKSELKHFQDEIKVINKNEIDENCEIFEDNFNLIEYKNMKEKFELFY
QAEGYRFVFLDQLNQKQILDKSQHTWKVVPVQIKSTIREIREEFVDNEFL
MRTKLSHLFRGVKVTIVTIDLPNALLEPITGGNLRILRSHQEQIYKARKE
DLDMRERIAKRAAERRSLPPRQRVLTTVNTENAQYSRLFDMIAEGFNTCT
LGIECLVPDDDYPHAQDCEHYASAKHHLSPLETAPTDEKFLGILRMKLNV
FHPDAAAAADNEALQPAVVTQCPSPAAAAVVPLLHAPPERLSSDELSLIK
EANRIAPYIVPRKPKSQNQQKKLRKLQKQSMKAAS*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000014	zeta neoblast
PLANA:0000101	muscle cell
PLANA:0002109	X1 cell
PLANA:0002111	X2 cell

Vocabulary: **INTERPRO**
Term	Definition
IPR039739	Mag2/Rnf10
IPR001841	Znf_RING
IPR013083	Znf_RING/FYVE/PHD
IPR018957	Znf_C3HC4_RING-type
IPR017907	Znf_RING_CS

Vocabulary: **molecular function**
Term	Definition
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding
GO:0003677	DNA binding
GO:0044212	transcription regulatory region DNA binding

Vocabulary: **cellular component**
Term	Definition
GO:0005634	nucleus
GO:0005737	cytoplasm

Vocabulary: **biological process**
Term	Definition
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0010626	negative regulation of Schwann cell proliferation
GO:0031643	positive regulation of myelination
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 194..221
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 517..536
None	No IPR available	CDD	cd16536	RING-HC_RNF10	coord: 51..92 e-value: 2.21977E-14 score: 65.2781
None	No IPR available	SUPERFAMILY	SSF57850	RING/U-box	coord: 30..96
IPR001841	Zinc finger, RING-type	SMART	SM00184	ring_2	coord: 51..92 e-value: 1.5E-6 score: 37.7
IPR001841	Zinc finger, RING-type	PROSITE	PS50089	ZF_RING_2	coord: 51..93 score: 12.357
IPR013083	Zinc finger, RING/FYVE/PHD-type	GENE3D	G3DSA:3.30.40.10		coord: 30..115 e-value: 3.5E-10 score: 41.5
IPR018957	Zinc finger, C3HC4 RING-type	PFAM	PF00097	zf-C3HC4	coord: 51..92 e-value: 3.9E-7 score: 29.8
IPR039739	RING-finger protein Mag2/Rnf10	PANTHER	PTHR12983	FAMILY NOT NAMED	coord: 3..372
IPR017907	Zinc finger, RING-type, conserved site	PROSITE	PS00518	ZF_RING_1	coord: 66..75

Main menu

RING-type domain-containing protein

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 4

Owlery

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