50S ribosomal protein L1
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30031548 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 1
Homology
BLAST of 50S ribosomal protein L1 vs. Ensembl Celegans
Match: mrpl-1 (Mitochondrial Ribosomal Protein, Large [Source:UniProtKB/TrEMBL;Acc:Q7KPW7]) HSP 1 Score: 68.9366 bits (167), Expect = 1.363e-12 Identity = 62/237 (26.16%), Postives = 118/237 (49.79%), Query Frame = 1 Query: 280 NVYMEKEFEKIKYSFEDATQFHQEYLLDKALYDSPNSVLKVNYLLNMXXXXXXXXXXXXXGIETPAHPFTFLTKPKILAFCTTQEDIDCAISXXXXXXXXXXXXXXXXQGHLFYEEFDQVVCHTEAXXXXXXXXXXXXXXXPTKQNSRIGPDIKSLVETYINGYEFESKKLEGIPEEAILSIPIGEISWPMEKLKENFLVFMRKIVLESSPQIAGSPISKISLICPPSDEIFFLDFQ 990 +V+++ F+ Y+ +A H+E L ++Y++PN+ +++ LNM T++ TK V I HPF K ILAF + + A+ GA A + KK+ +G +++D V H++ S + L+ +LK + PT+ N +G ++ L+E + NG + K P + +G +S P E ++ N + +P + GS +++ L+ P +E + +D + Sbjct: 100 DVFIKSHFKTQYYTVSEALDMHRE-LQSPSIYNNPNAPIRLRLELNMTTERQTKMVTGSDEIVPVPHPFNHNEKRTILAFANDVKLQELAVESGAEMALGQDTIKKIIKGQFRTDDYDFCVSHSDMGSSILPLRGILKMRFPTRANGGLGENLPELIEKFKNGVKLNIKGDPVYPIWGLSDCVVGRLSMPNEHIEANIATVIAAACAHRNPAL-GSFVNRALLMTIPGEENYAIDVK 334
BLAST of 50S ribosomal protein L1 vs. TrEMBL
Match: G4VLH1 (Putative 50s ribosomal protein L1 OS=Schistosoma mansoni OX=6183 GN=Smp_001960 PE=4 SV=1) HSP 1 Score: 135.191 bits (339), Expect = 2.382e-32 Identity = 99/302 (32.78%), Postives = 168/302 (55.63%), Query Frame = 1 Query: 97 RNISTS-QIYKKVQQTNRFKRMTVTNKSSSNK--MLDLKGEKNRTAWLKSIEEEETVKGKIANSNVYMEKEFEKIKYSFEDATQFHQEYLLDKALYDSPNSVLKVNYLLNMXXXXXXXXXXXXXGIETPAHPFTFLTKPKILAFCTTQEDIDCAISXXXXXXXXXXXXXXXXQGHLFYEEFDQVVCHTEAXXXXXXXXXXXXXXXPTKQNSRIGPDIKSLVETYINGYEFESKKLEGIPEEAILSIPIGEISWPMEKLKENFLVFMRKIVLESSPQIAGSPISKISLICPPSDEIFFLDFQE 993 RN+STS Q+++ QQ R ++TV KS S + +L + NRT W + + +KG+I S+ Y+ EFE KYS +A + +E +YD ++ ++V LNM TKK T+F+ KF G + F+ ++LA C +D + I+ GA +AG +L +++ QGH + E+D VV H ++KL+ +L+++LPT +N R+G D+ L+ + + ES ++G+PE +L I +G++SW +L+EN ++ I + S ++ I + CPP+ E F LD + Sbjct: 24 RNLSTSSQLFRNQQQRYREAKVTVNEKSKSRRDAARELLMKTNRTKWEQEMARLNILKGRIPTSDTYLMSEFEPKKYSLSEAVELLRESA-HPDMYDCMDNPVRVKVTLNMCTKKKTRFIPKFNGNLVLPNLLDFMPAHRVLAICQDSDDHEAYITAGAYDAGGSSLIQRISQGHYHWNEYDTVVAHQSWEIQVTKLRHILRERLPTIKNGRLGDDVMKLISIHSRSTQLESTSIDGVPEIGLLDIILGQLSWDFNRLEENLRSYLECIESQKSSRVINDFIQTGEIHCPPTGERFILDISQ 324
BLAST of 50S ribosomal protein L1 vs. TrEMBL
Match: A0A4E0RPC2 (50S ribosomal protein L1 OS=Fasciola hepatica OX=6192 GN=D915_000295 PE=4 SV=1) HSP 1 Score: 134.806 bits (338), Expect = 2.403e-32 Identity = 98/272 (36.03%), Postives = 153/272 (56.25%), Query Frame = 1 Query: 169 NKSSSNKMLDLKGEKNRTAWLKSIEEEETVKGKIANSNVYMEKEFEKIKYSFEDATQFHQEYLLDKALYDSPNSVLKVNYLLNMXXXXXXXXXXXXXGIETPAHPFTFLTKPKILAFCTTQEDIDCAISXXXXXXXXXXXXXXXXQGHLFYEEFDQVVCHTEAXXXXXXXXXXXXXXXPTKQNSRIGPDIKSLVETYINGYEFESKKLEGIPEEAILSIPIGEISWPMEKLKENFLVFMRKIVLESSPQIAGSPISKISLICPPSDEIFFLD 984 +K+ + ++ NR W ++ + GK ++NVY+ F++ F +A F +YD + L+ ++LNM+TKK TKF+ KF+ H +FL KP++LA C +D A+ GA +AG E L +LE G +EE+D VV H++ S+ +SKL+ VLK++LPT +N RIG D+ +LV TY+NG ES +LEG+PE L + +G++ W L +N L + I + S ++ G I + L CPP+ E F LD Sbjct: 52 SKARKDSAREILATANRIKWEQNNARRAELSGKKPSTNVYLASNFDQSGLKFSEAL-FALREASQPDMYDCMENPLRAKFVLNMQTKKKTKFIPKFEAHVVLPHQLSFLPKPRVLALCKNSDDAQMALDQGATDAGGEELFARLEHGAFHWEEYDFVVAHSDWSNTISKLRHVLKERLPTLKNGRIGEDVTTLVSTYVNGVSLESSQLEGVPEINHLDVIVGQLCWEDNALSDNMLCYFDTIESQKSSRVVGDAIESVHLSCPPTGEQFLLD 322
BLAST of 50S ribosomal protein L1 vs. TrEMBL
Match: A0A183MFL1 (Uncharacterized protein OS=Schistosoma margrebowiei OX=48269 GN=SMRZ_LOCUS14836 PE=4 SV=1) HSP 1 Score: 133.265 bits (334), Expect = 1.176e-31 Identity = 104/302 (34.44%), Postives = 170/302 (56.29%), Query Frame = 1 Query: 97 RNISTS-QIYKKVQQTNRFKRMTVTNKSSSNK--MLDLKGEKNRTAWLKSIEEEETVKGKIANSNVYMEKEFEKIKYSFEDATQFHQEYLLDKALYDSPNSVLKVNYLLNMXXXXXXXXXXXXXGIETPAHPFTFLTKPKILAFCTTQEDIDCAISXXXXXXXXXXXXXXXXQGHLFYEEFDQVVCHTEAXXXXXXXXXXXXXXXPTKQNSRIGPDIKSLVETYINGYEFESKKLEGIPEEAILSIPIGEISWPMEKLKENFLVFMRKIVLESSPQIAGSPISKISLICPPSDEIFFLDFQE 993 RN+STS Q++K QQ R ++TV KS S + +L + NRT W + + +KG+I S+ Y+ EFE KYS +A + +E +YD ++ ++V LNM TKK T+F+ KF+ + F+ ++LA C +D + ++ GA +AG AL +++ QGH + E+D VV H S ++KL+ +LKD+LPT +N R+G D+ L+ + N + ES ++G+PE +L I +G++SW +L+EN ++ I + S +I I + CPP+ E F LD + Sbjct: 24 RNLSTSSQLFKHQQQRYREAKVTVNEKSKSRRDAARELLMKTNRTKWEQEMARLNILKGRIPTSDTYLISEFEPKKYSLSEAVELLRESA-QPDMYDCMDNPVRVKVTLNMCTKKKTRFIPKFESNLVLPNVLDFMPVRRVLAICQNSDDREAYLTAGAYDAGGSALIQRVSQGHYHWGEYDTVVAHQSWESQVTKLRHILKDRLPTIKNGRLGEDVMKLMSIHSNSIQLESTSIDGVPEIGLLDIILGQLSWDFNRLEENLRSYLECIESQKSSRIINEFIQSGEIHCPPTGERFILDISQ 324
BLAST of 50S ribosomal protein L1 vs. TrEMBL
Match: A0A095BWE1 (50S ribosomal protein L1 OS=Schistosoma haematobium OX=6185 GN=MS3_01508 PE=4 SV=1) HSP 1 Score: 131.339 bits (329), Expect = 7.337e-31 Identity = 105/315 (33.33%), Postives = 174/315 (55.24%), Query Frame = 1 Query: 97 RNISTS-QIYKKVQQTNRFKRMTVTNKSSSNK--MLDLKGEKNRTAWLKSIEEEETVKGKIANSNVYMEKEFEKIKYSFEDATQFHQEYLLDKALYDSPNSVLKVNYLLNMXXXXXXXXXXXXXGIETPAHPFTFLTKPKILAFCTTQEDIDCAISXXXXXXXXXXXXXXXXQGHLFYEEFDQVVCHTEAXXXXXXXXXXXXXXXPTKQNSRIGPDIKSLVETYINGYEFESKKLEGIPEEAILSIPIGEISWPMEKLKENFLVFMRKIVLESSPQIAGSPISKISLICPPSDEIFFLDFQEDFERFAKMRQKSK 1032 RN+STS Q++K QQ R ++TV KS S + +L + NRT W + + + +KG+I S+ Y+ EFE KYS +A + +E +YD ++ ++V LNM TKK T+F+ KF+ + F+ ++L C +D + ++ GA +AG AL +++ QGH + E+D VV H S ++KL+ +LK++LPT +N R G D+ L+ + N + ES ++G+PE +L I +G++SW +L+EN ++ I + S +I I + CPP+ E F LD + + + KSK Sbjct: 24 RNLSTSSQLFKHQQQRYREAKVTVNEKSKSRRDAARELLMKTNRTKWEQEMAQLNILKGRIPTSDTYLISEFEPKKYSLSEAVELLRESA-QPDMYDCMDNPVRVKVTLNMCTKKKTRFIPKFESNLVLPNILDFMPARRVLVICQNSDDREAYLTAGAYDAGGSALIQRISQGHYHWGEYDTVVAHQSWESQVTKLRHILKERLPTIKNGRFGEDMMKLMSIHSNSIQLESTSIDGVPEIGLLDIILGQLSWDFNRLEENLRSYLECIESQKSSRIINEFIQSGEIHCPPTGERFILDISQ----YCSLGNKSK 333
BLAST of 50S ribosomal protein L1 vs. TrEMBL
Match: A0A074Z186 (Uncharacterized protein OS=Opisthorchis viverrini OX=6198 GN=T265_10805 PE=4 SV=1) HSP 1 Score: 129.028 bits (323), Expect = 2.814e-30 Identity = 103/305 (33.77%), Postives = 166/305 (54.43%), Query Frame = 1 Query: 97 RNISTSQIYKKVQQTNRFKRMTVT--------NKSSSNKMLDLKGEKNRTAWLKSIEEEETVKGKIANSNVYMEKEFEKIKYSFEDATQFHQEYLLDKALYDSPNSVLKVNYLLNMXXXXXXXXXXXXXGIETPAHPFTFLTKPKILAFCTTQEDIDCAISXXXXXXXXXXXXXXXXQGHLFYEEFDQVVCHTEAXXXXXXXXXXXXXXXPTKQNSRIGPDIKSLVETYINGYEFESKKLEGIPEEAILSIPIGEISWPMEKLKENFLVFMRKIVLESSPQIAGSPISKISLICPPSDEIFFLDF 987 R+++TS + ++ R R+T + +K + L NRT W + + + GK+ +NVY+ FE+ ++ +A + +E ++D + L+ + LNM+TKK TKF+QKF+G + FL K +++A C ED A+ GA+ AG L +LE G L +EE+D VV HT+ L KL+ VLKD+LPT +N RIG D+ +LV T+ G ES LEG+PE A L + IG+++W + +L+ N + I S +++G+ + + L CPP+ E F +D Sbjct: 18 RSLTTSS--RCLKGNTRKPRLTASGMGVISEKSKEKRDSARQLLATTNRTKWEDTNRKLAALTGKLPTTNVYLSANFEQRRFLLAEAAECLREAA-QPEMFDCLQNPLRAKFTLNMRTKKKTKFLQKFEGHVVLPNSLDFLPKSRVIALCNDAEDAALAVEAGAVHAGGTELFTRLENGSLHWEEYDTVVAHTDWEPTLKKLRHVLKDRLPTMRNGRIGSDVFTLVTTHSVGISVESTALEGVPEIAFLDVIIGQLAWDVTRLETNMQAYFDTIQSNKSSRVSGNAVLSVELYCPPTGERFPIDL 319
BLAST of 50S ribosomal protein L1 vs. Planmine SMEST
Match: SMESG000017111.1 (SMESG000017111.1) HSP 1 Score: 577.4 bits (1487), Expect = 0.000e+0 Identity = 330/331 (99.70%), Postives = 331/331 (100.00%), Query Frame = 1 Query: 58 MVLKCFFFGTLLRRNISTSQIYKKVQQTNRFKRMTVTNKSSSNKMLDLKGEKNRTAWLKSIEEEETVKGKIANSNVYMEKEFEKIKYSFEDATQFHQEYLLDKALYDSPNSVLKVNYLLNMXXXXXXXXXXXXXGIETPAHPFTFLTKPKILAFCTTQEDIDCAISXXXXXXXXXXXXXXXXQGHLFYEEFDQVVCHTEAXXXXXXXXXXXXXXXPTKQNSRIGPDIKSLVETYINGYEFESKKLEGIPEEAILSIPIGEISWPMEKLKENFLVFMRKIVLESSPQIAGSPISKISLICPPSDEIFFLDFQEDFERFAKMRQKSKLREEEE 1050 MVLKCFFFGTLLRRNISTSQIYKKVQQTNRFKRMTVTNKSSSNKMLDLKGEKNRTAWLKSIEEEETVKGKIANSNVYMEKEFEKIKYSFEDATQFHQEYLLDKALYDSPNSVLKVNYLLNMKTKKVTKFVQKFQGIETPAHPFTFLTKPKILAFCTTQEDIDCAISLGALEAGDEALAKKLEQGHLFYEEFDQVVCHTEASSLLSKLKSVLKDKLPTKQN+RIGPDIKSLVETYINGYEFESKKLEGIPEEAILSIPIGEISWPMEKLKENFLVFMRKIVLESSPQIAGSPISKISLICPPSDEIFFLDFQEDFERFAKMRQKSKLREEEE Sbjct: 1 MVLKCFFFGTLLRRNISTSQIYKKVQQTNRFKRMTVTNKSSSNKMLDLKGEKNRTAWLKSIEEEETVKGKIANSNVYMEKEFEKIKYSFEDATQFHQEYLLDKALYDSPNSVLKVNYLLNMKTKKVTKFVQKFQGIETPAHPFTFLTKPKILAFCTTQEDIDCAISLGALEAGDEALAKKLEQGHLFYEEFDQVVCHTEASSLLSKLKSVLKDKLPTKQNNRIGPDIKSLVETYINGYEFESKKLEGIPEEAILSIPIGEISWPMEKLKENFLVFMRKIVLESSPQIAGSPISKISLICPPSDEIFFLDFQEDFERFAKMRQKSKLREEEE 331
BLAST of 50S ribosomal protein L1 vs. Planmine SMEST
Match: SMESG000017111.1 (SMESG000017111.1) HSP 1 Score: 509.22 bits (1310), Expect = 0.000e+0 Identity = 297/298 (99.66%), Postives = 298/298 (100.00%), Query Frame = 1 Query: 157 MTVTNKSSSNKMLDLKGEKNRTAWLKSIEEEETVKGKIANSNVYMEKEFEKIKYSFEDATQFHQEYLLDKALYDSPNSVLKVNYLLNMXXXXXXXXXXXXXGIETPAHPFTFLTKPKILAFCTTQEDIDCAISXXXXXXXXXXXXXXXXQGHLFYEEFDQVVCHTEAXXXXXXXXXXXXXXXPTKQNSRIGPDIKSLVETYINGYEFESKKLEGIPEEAILSIPIGEISWPMEKLKENFLVFMRKIVLESSPQIAGSPISKISLICPPSDEIFFLDFQEDFERFAKMRQKSKLREEEE 1050 MTVTNKSSSNKMLDLKGEKNRTAWLKSIEEEETVKGKIANSNVYMEKEFEKIKYSFEDATQFHQEYLLDKALYDSPNSVLKVNYLLNMKTKKVTKFVQKFQGIETPAHPFTFLTKPKILAFCTTQEDIDCAISLGALEAGDEALAKKLEQGHLFYEEFDQVVCHTEASSLLSKLKSVLKDKLPTKQN+RIGPDIKSLVETYINGYEFESKKLEGIPEEAILSIPIGEISWPMEKLKENFLVFMRKIVLESSPQIAGSPISKISLICPPSDEIFFLDFQEDFERFAKMRQKSKLREEEE Sbjct: 1 MTVTNKSSSNKMLDLKGEKNRTAWLKSIEEEETVKGKIANSNVYMEKEFEKIKYSFEDATQFHQEYLLDKALYDSPNSVLKVNYLLNMKTKKVTKFVQKFQGIETPAHPFTFLTKPKILAFCTTQEDIDCAISLGALEAGDEALAKKLEQGHLFYEEFDQVVCHTEASSLLSKLKSVLKDKLPTKQNNRIGPDIKSLVETYINGYEFESKKLEGIPEEAILSIPIGEISWPMEKLKENFLVFMRKIVLESSPQIAGSPISKISLICPPSDEIFFLDFQEDFERFAKMRQKSKLREEEE 298 The following BLAST results are available for this feature:
BLAST of 50S ribosomal protein L1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of 50S ribosomal protein L1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 1
BLAST of 50S ribosomal protein L1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of 50S ribosomal protein L1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of 50S ribosomal protein L1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of 50S ribosomal protein L1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of 50S ribosomal protein L1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 0
BLAST of 50S ribosomal protein L1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of 50S ribosomal protein L1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of 50S ribosomal protein L1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of 50S ribosomal protein L1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of 50S ribosomal protein L1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of 50S ribosomal protein L1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of 50S ribosomal protein L1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 2
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30031548 ID=SMED30031548|Name=50S ribosomal protein L1|organism=Schmidtea mediterranea sexual|type=transcript|length=1165bpback to top protein sequence of SMED30031548-orf-1 >SMED30031548-orf-1 ID=SMED30031548-orf-1|Name=SMED30031548-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=332bp MVLKCFFFGTLLRRNISTSQIYKKVQQTNRFKRMTVTNKSSSNKMLDLKGback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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