Origin recognition complex subunit 4

Overview
NameOrigin recognition complex subunit 4
Smed IDSMED30031539
Length (bp)1362
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Origin recognition complex subunit 4 (SMED30031539) t-SNE clustered cells

Violin plots show distribution of expression levels for Origin recognition complex subunit 4 (SMED30031539) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Origin recognition complex subunit 4 (SMED30031539) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Origin recognition complex subunit 4 (SMED30031539) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30031539

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 10

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30031539SMESG000043431.1 SmedASXL_010449SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
X2 cellSMED30031539SMESG000043431.1 SmedASXL_010449SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
neoblastSMED30031539SMESG000043431.1 dd_Smed_v4_11263_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parapharyngeal regionSMED30031539SMESG000043431.1 dd_Smed_v6_11263_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
zeta neoblastSMED30031539SMESG000043431.1 dd_Smed_v4_11263_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
neoblastSMED30031539SMESG000043431.1 SMED_26316_V2_1GPL14150PMID:22385657
Wagner et al., 2012		whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30031539SMESG000043431.1 SMED_26316_V2_1GPL14150_gene_modelsPMID:22385657
Wagner et al., 2012		whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30031539SMESG000043431.1 SmWIOct06_038232GPL14150_gene_modelsPMID:22385657
Wagner et al., 2012		whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30031539SMESG000043431.1 SMED_21206_V2_1GPL14150_gene_modelsPMID:22385657
Wagner et al., 2012		whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30031539SMESG000043431.1 SMED_21206_V2_1GPL14150PMID:22385657
Wagner et al., 2012		whole organism asexual adult cDNA to DNA expression microarray evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Origin recognition complex subunit 4 vs. Ensembl Human
Match: ORC4 (origin recognition complex subunit 4 [Source:HGNC Symbol;Acc:HGNC:8490])

HSP 1 Score: 220.32 bits (560), Expect = 2.991e-66
Identity = 146/371 (39.35%), Postives = 220/371 (59.30%), Query Frame = 2 
Query:  137 SSNHEFFGYENYESRIIPSIKNAYIHGESNSMMIIGKRGSGKTHLIKSLLNDLNNDEKFRDNVYQVNLNGLLHTDDKCALKSIAFQLKCHLIENEEEEFTSDNFNENFEYILSFLTSGDRNSICXXXXXX-XXXXXXQHTNQILIYNILNCVQSKGTPIFVLGTTTRLDILELMEKRVKSRFSHCQISMI-PFGTTIDLYVESMRKLLTISNEANSKLI-QRWNDSVKRFSNDSNVLKVLERNFMLSNLIGQLKRLLMIPISRLSSTDVELRVTDLQESWKIVNVDYKTEILYGLCELEFTLLAVI--VNCIAKRESDVNFEMVYREYNEFCKTSYSNSY--DKNVLRKCLDHLLDLDLVGMKKGKTGNSN 1228
            S +   FG +     +   +K   +HGESNS++IIG RGSGKT LI   L +L   E+  +NV QV+LNGLL  +DK ALK I  QL    +EN   +    +F EN  ++L  L  GDR S C +  I  EFDLF  H NQ L+YN+ +  QS  TPI V+G T RLDILEL+EKRVKSRFSH QI ++  FG     YV+  ++ L++  E   K+  ++WN++V+  S D +V +VL+++F +S  +  L  LLM+ ++R++++   +   DL E+ ++ ++D K  I++GL  LE  L+  +  +N I + E   NF+MVY E+ +F +    + Y  +K V+ K  +HL  L+L+   +  +GNS 
Sbjct:   32 SPHSNLFGVQVQYKHLSELLKRTALHGESNSVLIIGPRGSGKTMLINHALKELMEIEEVSENVLQVHLNGLLQINDKIALKEITRQLN---LENVVGDKVFGSFAENLSFLLEALKKGDRTSSCPVIFILDEFDLFAHHKNQTLLYNLFDISQSAQTPIAVIGLTCRLDILELLEKRVKSRFSHRQIHLMNSFG--FPQYVKIFKEQLSLPAEFPDKVFAEKWNENVQYLSEDRSVQEVLQKHFNISKNLRSLHMLLMLALNRVTASHPFMTAVDLMEASQLCSMDSKANIVHGLSVLEICLIIAMKHLNDIYEEEP-FNFQMVYNEFQKFVQRKAHSVYNFEKPVVMKAFEHLQQLELIKPMERTSGNSQ 396
[Close]
BLAST of Origin recognition complex subunit 4 vs. Ensembl Human
Match: ORC4 (origin recognition complex subunit 4 [Source:HGNC Symbol;Acc:HGNC:8490])

HSP 1 Score: 220.32 bits (560), Expect = 2.991e-66
Identity = 146/371 (39.35%), Postives = 220/371 (59.30%), Query Frame = 2 
Query:  137 SSNHEFFGYENYESRIIPSIKNAYIHGESNSMMIIGKRGSGKTHLIKSLLNDLNNDEKFRDNVYQVNLNGLLHTDDKCALKSIAFQLKCHLIENEEEEFTSDNFNENFEYILSFLTSGDRNSICXXXXXX-XXXXXXQHTNQILIYNILNCVQSKGTPIFVLGTTTRLDILELMEKRVKSRFSHCQISMI-PFGTTIDLYVESMRKLLTISNEANSKLI-QRWNDSVKRFSNDSNVLKVLERNFMLSNLIGQLKRLLMIPISRLSSTDVELRVTDLQESWKIVNVDYKTEILYGLCELEFTLLAVI--VNCIAKRESDVNFEMVYREYNEFCKTSYSNSY--DKNVLRKCLDHLLDLDLVGMKKGKTGNSN 1228
            S +   FG +     +   +K   +HGESNS++IIG RGSGKT LI   L +L   E+  +NV QV+LNGLL  +DK ALK I  QL    +EN   +    +F EN  ++L  L  GDR S C +  I  EFDLF  H NQ L+YN+ +  QS  TPI V+G T RLDILEL+EKRVKSRFSH QI ++  FG     YV+  ++ L++  E   K+  ++WN++V+  S D +V +VL+++F +S  +  L  LLM+ ++R++++   +   DL E+ ++ ++D K  I++GL  LE  L+  +  +N I + E   NF+MVY E+ +F +    + Y  +K V+ K  +HL  L+L+   +  +GNS 
Sbjct:   32 SPHSNLFGVQVQYKHLSELLKRTALHGESNSVLIIGPRGSGKTMLINHALKELMEIEEVSENVLQVHLNGLLQINDKIALKEITRQLN---LENVVGDKVFGSFAENLSFLLEALKKGDRTSSCPVIFILDEFDLFAHHKNQTLLYNLFDISQSAQTPIAVIGLTCRLDILELLEKRVKSRFSHRQIHLMNSFG--FPQYVKIFKEQLSLPAEFPDKVFAEKWNENVQYLSEDRSVQEVLQKHFNISKNLRSLHMLLMLALNRVTASHPFMTAVDLMEASQLCSMDSKANIVHGLSVLEICLIIAMKHLNDIYEEEP-FNFQMVYNEFQKFVQRKAHSVYNFEKPVVMKAFEHLQQLELIKPMERTSGNSQ 396
[Close]
BLAST of Origin recognition complex subunit 4 vs. Ensembl Human
Match: ORC4 (origin recognition complex subunit 4 [Source:HGNC Symbol;Acc:HGNC:8490])

HSP 1 Score: 220.32 bits (560), Expect = 2.991e-66
Identity = 146/371 (39.35%), Postives = 220/371 (59.30%), Query Frame = 2 
Query:  137 SSNHEFFGYENYESRIIPSIKNAYIHGESNSMMIIGKRGSGKTHLIKSLLNDLNNDEKFRDNVYQVNLNGLLHTDDKCALKSIAFQLKCHLIENEEEEFTSDNFNENFEYILSFLTSGDRNSICXXXXXX-XXXXXXQHTNQILIYNILNCVQSKGTPIFVLGTTTRLDILELMEKRVKSRFSHCQISMI-PFGTTIDLYVESMRKLLTISNEANSKLI-QRWNDSVKRFSNDSNVLKVLERNFMLSNLIGQLKRLLMIPISRLSSTDVELRVTDLQESWKIVNVDYKTEILYGLCELEFTLLAVI--VNCIAKRESDVNFEMVYREYNEFCKTSYSNSY--DKNVLRKCLDHLLDLDLVGMKKGKTGNSN 1228
            S +   FG +     +   +K   +HGESNS++IIG RGSGKT LI   L +L   E+  +NV QV+LNGLL  +DK ALK I  QL    +EN   +    +F EN  ++L  L  GDR S C +  I  EFDLF  H NQ L+YN+ +  QS  TPI V+G T RLDILEL+EKRVKSRFSH QI ++  FG     YV+  ++ L++  E   K+  ++WN++V+  S D +V +VL+++F +S  +  L  LLM+ ++R++++   +   DL E+ ++ ++D K  I++GL  LE  L+  +  +N I + E   NF+MVY E+ +F +    + Y  +K V+ K  +HL  L+L+   +  +GNS 
Sbjct:   32 SPHSNLFGVQVQYKHLSELLKRTALHGESNSVLIIGPRGSGKTMLINHALKELMEIEEVSENVLQVHLNGLLQINDKIALKEITRQLN---LENVVGDKVFGSFAENLSFLLEALKKGDRTSSCPVIFILDEFDLFAHHKNQTLLYNLFDISQSAQTPIAVIGLTCRLDILELLEKRVKSRFSHRQIHLMNSFG--FPQYVKIFKEQLSLPAEFPDKVFAEKWNENVQYLSEDRSVQEVLQKHFNISKNLRSLHMLLMLALNRVTASHPFMTAVDLMEASQLCSMDSKANIVHGLSVLEICLIIAMKHLNDIYEEEP-FNFQMVYNEFQKFVQRKAHSVYNFEKPVVMKAFEHLQQLELIKPMERTSGNSQ 396
[Close]
BLAST of Origin recognition complex subunit 4 vs. Ensembl Human
Match: ORC4 (origin recognition complex subunit 4 [Source:HGNC Symbol;Acc:HGNC:8490])

HSP 1 Score: 183.726 bits (465), Expect = 3.074e-53
Identity = 124/327 (37.92%), Postives = 192/327 (58.72%), Query Frame = 2 
Query:  269 LIKSLLNDLNNDEKFRDNVYQVNLNGLLHTDDKCALKSIAFQLKCHLIENEEEEFTSDNFNENFEYILSFLTSGDRNSICXXXXXXXXX-XXXQHTNQILIYNILNCVQSKGTPIFVLGTTTRLDILELMEKRVKSRFSHCQISMI-PFGTTIDLYVESMRKLLTISNEANSKLI-QRWNDSVKRFSNDSNVLKVLERNFMLSNLIGQLKRLLMIPISRLSSTDVELRVTDLQESWKIVNVDYKTEILYGLCELEFTLLAVI--VNCIAKRESDVNFEMVYREYNEFCKTSYSNSY--DKNVLRKCLDHLLDLDLVGMKKGKTGNSN 1228
            LI   L +L   E+  +NV QV+LNGLL  +DK ALK I  QL    +EN   +    +F EN  ++L  L  GDR S C +  I +   LF  H NQ L+YN+ +  QS  TPI V+G T RLDILEL+EKRVKSRFSH QI ++  FG     YV+  ++ L++  E   K+  ++WN++V+  S D +V +VL+++F +S  +  L  LLM+ ++R++++   +   DL E+ ++ ++D K  I++GL  LE  L+  +  +N I + E   NF+MVY E+ +F +    + Y  +K V+ K  +HL  L+L+   +  +GNS 
Sbjct:    2 LINHALKELMEIEEVSENVLQVHLNGLLQINDKIALKEITRQLN---LENVVGDKVFGSFAENLSFLLEALKKGDRTSSCPVIFILDEFDLFAHHKNQTLLYNLFDISQSAQTPIAVIGLTCRLDILELLEKRVKSRFSHRQIHLMNSFG--FPQYVKIFKEQLSLPAEFPDKVFAEKWNENVQYLSEDRSVQEVLQKHFNISKNLRSLHMLLMLALNRVTASHPFMTAVDLMEASQLCSMDSKANIVHGLSVLEICLIIAMKHLNDIYEEEP-FNFQMVYNEFQKFVQRKAHSVYNFEKPVVMKAFEHLQQLELIKPMERTSGNSQ 322
[Close]
BLAST of Origin recognition complex subunit 4 vs. Ensembl Human
Match: ORC4 (origin recognition complex subunit 4 [Source:HGNC Symbol;Acc:HGNC:8490])

HSP 1 Score: 180.259 bits (456), Expect = 4.924e-52
Identity = 120/315 (38.10%), Postives = 187/315 (59.37%), Query Frame = 2 
Query:  305 EKFRDNVYQVNLNGLLHTDDKCALKSIAFQLKCHLIENEEEEFTSDNFNENFEYILSFLTSGDRNSICXXXXXXXXX-XXXQHTNQILIYNILNCVQSKGTPIFVLGTTTRLDILELMEKRVKSRFSHCQISMI-PFGTTIDLYVESMRKLLTISNEANSKLI-QRWNDSVKRFSNDSNVLKVLERNFMLSNLIGQLKRLLMIPISRLSSTDVELRVTDLQESWKIVNVDYKTEILYGLCELEFTLLAVI--VNCIAKRESDVNFEMVYREYNEFCKTSYSNSY--DKNVLRKCLDHLLDLDLVGMKKGKTGNSN 1228
            E+  +NV QV+LNGLL  +DK ALK I  QL    +EN   +    +F EN  ++L  L  GDR S C +  I +   LF  H NQ L+YN+ +  QS  TPI V+G T RLDILEL+EKRVKSRFSH QI ++  FG     YV+  ++ L++  E   K+  ++WN++V+  S D +V +VL+++F +S  +  L  LLM+ ++R++++   +   DL E+ ++ ++D K  I++GL  LE  L+  +  +N I + E   NF+MVY E+ +F +    + Y  +K V+ K  +HL  L+L+   +  +GNS 
Sbjct:    4 EEVSENVLQVHLNGLLQINDKIALKEITRQLN---LENVVGDKVFGSFAENLSFLLEALKKGDRTSSCPVIFILDEFDLFAHHKNQTLLYNLFDISQSAQTPIAVIGLTCRLDILELLEKRVKSRFSHRQIHLMNSFG--FPQYVKIFKEQLSLPAEFPDKVFAEKWNENVQYLSEDRSVQEVLQKHFNISKNLRSLHMLLMLALNRVTASHPFMTAVDLMEASQLCSMDSKANIVHGLSVLEICLIIAMKHLNDIYEEEP-FNFQMVYNEFQKFVQRKAHSVYNFEKPVVMKAFEHLQQLELIKPMERTSGNSQ 312
[Close]
BLAST of Origin recognition complex subunit 4 vs. Ensembl Fly
Match: Orc4 (gene:FBgn0023181 transcript:FBtr0072425)

HSP 1 Score: 156.377 bits (394), Expect = 2.505e-42
Identity = 126/386 (32.64%), Postives = 194/386 (50.26%), Query Frame = 2 
Query:  158 GYENYESRIIPSIKNAYIHGESNSMMIIGKRGSGKTHLIKSLLNDLNNDEKFRDNVYQVNLNGLLHTDDKCALKSIAFQLKCHLIENEEEEFTSDNFNENFEYILSFLTSGDRNSICXXXXXXXXXXXXQHTNQILIYNILNCVQSKGTPIFVLGTTTRLDILELMEKRVKSRFSHCQISMIPFGTTIDLYVESMRKLLTISNEANSKLIQ-----------------------------------RWNDSVKRFSNDSNVLKVLE--RNFMLSNLIGQLKRLLMIPISRLSSTDVELRVTDLQESWKIVNVDYKTEILYGLCELEFTLLAVIVN--CIAKRESDVNFEMVYREYNEFCKTSYS-NSYDKNVLRKCLDHLLDLDLV 1195
            GY    S +   ++     GESNS++++G RGSGKT LI S+L DL  ++ F +N   V+L+G LHTDD+ ALKSI  Q++   +EN  +     +F EN  ++L  L +G ++S  ++FI+EEFDLF  H NQ L+YN+ +  QS   PI VLG T RLD++EL+EKRVKSRFSH Q+ + P     + YV+  R LL++    NS L+                                     WN  + +          L+   +F +S     LK  L   ++ L      +    +         D K E+L GL  LE  L+  I +   I  R+S  NFE++Y  +++F K S +  + +++++ K  +HL   +L+
Sbjct:   28 GYAKERSNVRLLLQRTAEMGESNSLLLLGPRGSGKTTLINSVLADLLPNKSFGENTLIVHLDGNLHTDDRVALKSITVQMQ---LENAADGKVFGSFAENLAFLLQCLKAGGKHSKSVIFILEEFDLFCAHHNQTLLYNLFDVSQSAQAPICVLGVTCRLDVIELLEKRVKSRFSHRQVFLFPSLRRFEDYVDLCRDLLSLPT-GNSLLLAAEKIYNLQNIQSGALYFSRNHFDPGEYGFSPRLRDAWNKQICKVLATQQARSTLQALHDFDISE--AYLKNFLFRLVAHLRPQSPHITAEKMAAVGSQFEGDDKIELLCGLSVLELCLIIAIKHHSQIYDRDS-FNFEIIYARFSKFAKVSTTMQAVERSIVLKAFEHLRIAELI 406
[Close]
BLAST of Origin recognition complex subunit 4 vs. Ensembl Zebrafish
Match: orc4 (origin recognition complex, subunit 4 [Source:ZFIN;Acc:ZDB-GENE-040426-2224])

HSP 1 Score: 204.527 bits (519), Expect = 1.581e-60
Identity = 135/351 (38.46%), Postives = 211/351 (60.11%), Query Frame = 2 
Query:  158 GYENYESRIIPSIKNAYIHGESNSMMIIGKRGSGKTHLIKSLLNDLNNDEKFRDNVYQVNLNGLLHTDDKCALKSIAFQLKCHLIENEEEEFTSDNFNENFEYILSFLTSGDRNSI-CXXXXXXXXXXXXQHTNQILIYNILNCVQSKGTPIFVLGTTTRLDILELMEKRVKSRFSHCQISMIPFGTTIDLYVESMRKLLTISNE-ANSKLIQRWNDSVKRFSNDSNVLKVLERNFMLSNLIGQLKRLLMIPISRLSSTDVELRVTDLQESWKIVNVDYKTEILYGLCELEFTLLAVIVNCIAKRESD-VNFEMVYREYNEFC--KTSYSNSYDKNVLRKCLDHLLDLDLV 1195
            G ++    ++  ++   +HGESNS++I+G RGSGKT L+  +L +L + ++ + NV  V LNGLL TDDK ALK I  QL    +EN   +    +F EN  ++L  L  GD++S   +LF+++EFDLF  H NQ L+YN+L+  QS  TP+ V+G T RLD+LEL+EKRVKSRFSH QI +     +   YV+ +R  L++  +  + +   +WN SV +   D +VL+VL+R+F  S     L  LL + +SR+S +   L   D  ES ++++ D K  +L+GL  LE  L+  + +     + +  NF+MV+ E+ +F   K+   + ++K V+ K  +HLL L+LV
Sbjct:   37 GLDSQYKHLLELLRRTAVHGESNSVLIVGPRGSGKTMLLGCVLRELMSLKEVQKNVLLVELNGLLQTDDKIALKEITRQLH---LENVVGDKVFGSFAENLAFLLEALKKGDKSSSRPVLFLLDEFDLFAHHKNQTLLYNLLDVSQSAQTPVAVVGLTCRLDVLELLEKRVKSRFSHRQIHLFS-SLSFSQYVDVVRLQLSLPQDFPDHRFSSQWNQSVTKLCEDKSVLEVLKRSFNSSKDFRSLYSLLFMAVSRVSVSHSTLCEADFLESGRLISADSKANVLHGLSILELCLIIAMKHLNDTYDGEPFNFQMVHNEFKKFIQRKSHSIHKFEKPVVMKAFEHLLQLELV 383
[Close]
BLAST of Origin recognition complex subunit 4 vs. Ensembl Zebrafish
Match: orc4 (origin recognition complex, subunit 4 [Source:ZFIN;Acc:ZDB-GENE-040426-2224])

HSP 1 Score: 204.527 bits (519), Expect = 1.581e-60
Identity = 135/351 (38.46%), Postives = 211/351 (60.11%), Query Frame = 2 
Query:  158 GYENYESRIIPSIKNAYIHGESNSMMIIGKRGSGKTHLIKSLLNDLNNDEKFRDNVYQVNLNGLLHTDDKCALKSIAFQLKCHLIENEEEEFTSDNFNENFEYILSFLTSGDRNSI-CXXXXXXXXXXXXQHTNQILIYNILNCVQSKGTPIFVLGTTTRLDILELMEKRVKSRFSHCQISMIPFGTTIDLYVESMRKLLTISNE-ANSKLIQRWNDSVKRFSNDSNVLKVLERNFMLSNLIGQLKRLLMIPISRLSSTDVELRVTDLQESWKIVNVDYKTEILYGLCELEFTLLAVIVNCIAKRESD-VNFEMVYREYNEFC--KTSYSNSYDKNVLRKCLDHLLDLDLV 1195
            G ++    ++  ++   +HGESNS++I+G RGSGKT L+  +L +L + ++ + NV  V LNGLL TDDK ALK I  QL    +EN   +    +F EN  ++L  L  GD++S   +LF+++EFDLF  H NQ L+YN+L+  QS  TP+ V+G T RLD+LEL+EKRVKSRFSH QI +     +   YV+ +R  L++  +  + +   +WN SV +   D +VL+VL+R+F  S     L  LL + +SR+S +   L   D  ES ++++ D K  +L+GL  LE  L+  + +     + +  NF+MV+ E+ +F   K+   + ++K V+ K  +HLL L+LV
Sbjct:   37 GLDSQYKHLLELLRRTAVHGESNSVLIVGPRGSGKTMLLGCVLRELMSLKEVQKNVLLVELNGLLQTDDKIALKEITRQLH---LENVVGDKVFGSFAENLAFLLEALKKGDKSSSRPVLFLLDEFDLFAHHKNQTLLYNLLDVSQSAQTPVAVVGLTCRLDVLELLEKRVKSRFSHRQIHLFS-SLSFSQYVDVVRLQLSLPQDFPDHRFSSQWNQSVTKLCEDKSVLEVLKRSFNSSKDFRSLYSLLFMAVSRVSVSHSTLCEADFLESGRLISADSKANVLHGLSILELCLIIAMKHLNDTYDGEPFNFQMVHNEFKKFIQRKSHSIHKFEKPVVMKAFEHLLQLELV 383
[Close]
BLAST of Origin recognition complex subunit 4 vs. Ensembl Xenopus
Match: ppil4 (peptidylprolyl isomerase like 4 [Source:Xenbase;Acc:XB-GENE-975086])

HSP 1 Score: 213.386 bits (542), Expect = 1.056e-63
Identity = 127/383 (33.16%), Postives = 214/383 (55.87%), Query Frame = 2 
Query:   98 MSDIVSPLRRKIYSSNHEFFGYENYESRIIPSIKNAYIHGESNSMMIIGKRGSGKTHLIKSLLNDLNNDEKFRDNVYQVNLNGLLHTDDKCALKSIAFQLKCHLIENEEEEFTSDNFNENFEYILSFLTSGDRNSICXXXXXXXXXXX-XQHTNQILIYNILNCVQSKGTPIFVLGTTTRLDILELMEKRVKSRFSHCQISMI---PFGTTIDLYVESMRKLLTISNEANSKLIQRWNDSVKRFSNDSNVLKVLERNFMLSNLIGQLKRLLMIPISRLSSTDVELRVTDLQESWKIVNVDYKTEILYGLCELEFTLLAVIVNCIAKRESDV------NFEMVYREYNEFCKTSYSNSY--DKNVLRKCLDHLLDLDLVGMKKG 1210
            +S + + LR++++  + + FG ++    ++  +K   +HGESNS +IIG RGSGK+ L+K  L ++   ++ ++N  QV LNGLL T DK ALK I  QL    +EN   +    +F EN  ++L  L +GDR S C + ++ +       H NQ L+YN+ +  QS  TP+ V+G T RLD++EL+EKRVKSRFSH QI ++    F   ++++ E   KL   ++  +S+  ++WN+S+K       V  +L++ +  S  +  L  LL++ + R+S +   +   D  E +++ N D K  I++GL  LE  L+  +     K   D+      NF+MV+ E+ +F +    + Y  +K V+ K  +HL  L+L+   +G
Sbjct:   17 ISRVHAILRQRLFQHHGKPFGVDSQHKHLVELLKRTVVHGESNSALIIGPRGSGKSMLLKGALEEILAMKQVKENALQVRLNGLLQTTDKIALKEITRQLH---LENVVGDRVFGSFAENLAFLLEALKTGDRKSSCPVLLLLDEFDLFAHHKNQTLLYNLFDIAQSAQTPVAVIGLTCRLDVMELLEKRVKSRFSHRQIHLLNSFSFIQYLEIFQE---KLFLPASFPDSQFAEKWNESIKSLVESKMVEDILQKQYSASKDVRSLHMLLLLAVCRVSVSHPHITAADFLEVFRLRNQDSKANIMHGLSVLELCLIIAM-----KHLQDIYDGEPFNFQMVHNEFQKFIQRKAHSVYNFEKPVVMKAFEHLHQLELIKPMEG 388
[Close]
BLAST of Origin recognition complex subunit 4 vs. Ensembl Xenopus
Match: ppil4 (peptidylprolyl isomerase like 4 [Source:Xenbase;Acc:XB-GENE-975086])

HSP 1 Score: 213.386 bits (542), Expect = 1.134e-63
Identity = 127/383 (33.16%), Postives = 214/383 (55.87%), Query Frame = 2 
Query:   98 MSDIVSPLRRKIYSSNHEFFGYENYESRIIPSIKNAYIHGESNSMMIIGKRGSGKTHLIKSLLNDLNNDEKFRDNVYQVNLNGLLHTDDKCALKSIAFQLKCHLIENEEEEFTSDNFNENFEYILSFLTSGDRNSICXXXXXXXXXXX-XQHTNQILIYNILNCVQSKGTPIFVLGTTTRLDILELMEKRVKSRFSHCQISMI---PFGTTIDLYVESMRKLLTISNEANSKLIQRWNDSVKRFSNDSNVLKVLERNFMLSNLIGQLKRLLMIPISRLSSTDVELRVTDLQESWKIVNVDYKTEILYGLCELEFTLLAVIVNCIAKRESDV------NFEMVYREYNEFCKTSYSNSY--DKNVLRKCLDHLLDLDLVGMKKG 1210
            +S + + LR++++  + + FG ++    ++  +K   +HGESNS +IIG RGSGK+ L+K  L ++   ++ ++N  QV LNGLL T DK ALK I  QL    +EN   +    +F EN  ++L  L +GDR S C + ++ +       H NQ L+YN+ +  QS  TP+ V+G T RLD++EL+EKRVKSRFSH QI ++    F   ++++ E   KL   ++  +S+  ++WN+S+K       V  +L++ +  S  +  L  LL++ + R+S +   +   D  E +++ N D K  I++GL  LE  L+  +     K   D+      NF+MV+ E+ +F +    + Y  +K V+ K  +HL  L+L+   +G
Sbjct:   17 ISRVHAILRQRLFQHHGKPFGVDSQHKHLVELLKRTVVHGESNSALIIGPRGSGKSMLLKGALEEILAMKQVKENALQVRLNGLLQTTDKIALKEITRQLH---LENVVGDRVFGSFAENLAFLLEALKTGDRKSSCPVLLLLDEFDLFAHHKNQTLLYNLFDIAQSAQTPVAVIGLTCRLDVMELLEKRVKSRFSHRQIHLLNSFSFIQYLEIFQE---KLFLPASFPDSQFAEKWNESIKSLVESKMVEDILQKQYSASKDVRSLHMLLLLAVCRVSVSHPHITAADFLEVFRLRNQDSKANIMHGLSVLELCLIIAM-----KHLQDIYDGEPFNFQMVHNEFQKFIQRKAHSVYNFEKPVVMKAFEHLHQLELIKPMEG 388
[Close]
BLAST of Origin recognition complex subunit 4 vs. Ensembl Xenopus
Match: ppil4 (peptidylprolyl isomerase like 4 [Source:Xenbase;Acc:XB-GENE-975086])

HSP 1 Score: 202.601 bits (514), Expect = 9.722e-60
Identity = 124/351 (35.33%), Postives = 197/351 (56.13%), Query Frame = 2 
Query:  194 IKNAYIHGESNSMMIIGKRGSGKTHLIKSLLNDLNNDEKFRDNVYQVNLNGLLHTDDKCALKSIAFQLKCHLIENEEEEFTSDNFNENFEYILSFLTSGDRNSICXXXXXXXXXXX-XQHTNQILIYNILNCVQSKGTPIFVLGTTTRLDILELMEKRVKSRFSHCQISMI---PFGTTIDLYVESMRKLLTISNEANSKLIQRWNDSVKRFSNDSNVLKVLERNFMLSNLIGQLKRLLMIPISRLSSTDVELRVTDLQESWKIVNVDYKTEILYGLCELEFTLLAVIVNCIAKRESDV------NFEMVYREYNEFCKTSYSNSY--DKNVLRKCLDHLLDLDLVGMKKG 1210
            +K   +HGESNS +IIG RGSGK+ L+K  L ++   ++ ++N  QV LNGLL T DK ALK I  QL  HL EN   +    +F EN  ++L  L +GDR S C + ++ +       H NQ L+YN+ +  QS  TP+ V+G T RLD++EL+EKRVKSRFSH QI ++    F   ++++ E   KL   ++  +S+  ++WN+S+K       V  +L++ +  S  +  L  LL++ + R+S +   +   D  E +++ N D K  I++GL  LE  L+  +     K   D+      NF+MV+ E+ +F +    + Y  +K V+ K  +HL  L+L+   +G
Sbjct:   45 LKRTVVHGESNSALIIGPRGSGKSMLLKGALEEILAMKQVKENALQVRLNGLLQTTDKIALKEITRQL--HL-ENVVGDRVFGSFAENLAFLLEALKTGDRKSSCPVLLLLDEFDLFAHHKNQTLLYNLFDIAQSAQTPVAVIGLTCRLDVMELLEKRVKSRFSHRQIHLLNSFSFIQYLEIFQE---KLFLPASFPDSQFAEKWNESIKSLVESKMVEDILQKQYSASKDVRSLHMLLLLAVCRVSVSHPHITAADFLEVFRLRNQDSKANIMHGLSVLELCLIIAM-----KHLQDIYDGEPFNFQMVHNEFQKFIQRKAHSVYNFEKPVVMKAFEHLHQLELIKPMEG 384
[Close]
BLAST of Origin recognition complex subunit 4 vs. Ensembl Xenopus
Match: ppil4 (peptidylprolyl isomerase like 4 [Source:Xenbase;Acc:XB-GENE-975086])

HSP 1 Score: 202.216 bits (513), Expect = 1.231e-59
Identity = 124/355 (34.93%), Postives = 199/355 (56.06%), Query Frame = 2 
Query:  182 IIPSIKNAYIHGESNSMMIIGKRGSGKTHLIKSLLNDLNNDEKFRDNVYQVNLNGLLHTDDKCALKSIAFQLKCHLIENEEEEFTSDNFNENFEYILSFLTSGDRNSICXXXXXXXXXXX-XQHTNQILIYNILNCVQSKGTPIFVLGTTTRLDILELMEKRVKSRFSHCQISMI---PFGTTIDLYVESMRKLLTISNEANSKLIQRWNDSVKRFSNDSNVLKVLERNFMLSNLIGQLKRLLMIPISRLSSTDVELRVTDLQESWKIVNVDYKTEILYGLCELEFTLLAVIVNCIAKRESDV------NFEMVYREYNEFCKTSYSNSY--DKNVLRKCLDHLLDLDLVGMKKG 1210
            ++  +K   +HGESNS +IIG RGSGK+ L+K  L ++   ++ ++N  QV LNGLL T DK ALK I  QL  HL EN   +    +F EN  ++L  L +GDR S C + ++ +       H NQ L+YN+ +  QS  TP+ V+G T RLD++EL+EKRVKSRFSH QI ++    F   ++++ E   KL   ++  +S+  ++WN+S+K       V  +L++ +  S  +  L  LL++ + R+S +   +   D  E +++ N D K  I++GL  LE  L+  +     K   D+      NF+MV+ E+ +F +    + Y  +K V+ K  +HL  L+L+   +G
Sbjct:   33 LVELLKRTVVHGESNSALIIGPRGSGKSMLLKGALEEILAMKQVKENALQVRLNGLLQTTDKIALKEITRQL--HL-ENVVGDRVFGSFAENLAFLLEALKTGDRKSSCPVLLLLDEFDLFAHHKNQTLLYNLFDIAQSAQTPVAVIGLTCRLDVMELLEKRVKSRFSHRQIHLLNSFSFIQYLEIFQE---KLFLPASFPDSQFAEKWNESIKSLVESKMVEDILQKQYSASKDVRSLHMLLLLAVCRVSVSHPHITAADFLEVFRLRNQDSKANIMHGLSVLELCLIIAM-----KHLQDIYDGEPFNFQMVHNEFQKFIQRKAHSVYNFEKPVVMKAFEHLHQLELIKPMEG 376
[Close]
BLAST of Origin recognition complex subunit 4 vs. Ensembl Xenopus
Match: ppil4 (peptidylprolyl isomerase like 4 [Source:Xenbase;Acc:XB-GENE-975086])

HSP 1 Score: 196.823 bits (499), Expect = 1.436e-57
Identity = 128/378 (33.86%), Postives = 214/378 (56.61%), Query Frame = 2 
Query:   98 MSDIVSPLRRKIYSSNHEFFGYENYESRIIPSIKNAYIHGESNSMMIIGKRGSGKTHLIKSLLNDLNNDEKFRDNVYQVNLNGLLHTDDKCALKSIAFQLKCHLIENEEEEFTSDNFNENFEYILSFLTSGDRNSICXX-XXXXXXXXXXQHTNQILIYNILNCVQSKGTPIFVLGTTTRLDILELMEKRVKSRFSHCQISMI---PFGTTIDLYVESMRKLLTISNEANSKLIQRWNDSVKRFSNDSNVLKVLERNFMLSNLIGQLKRLLMIPISRLSSTDVELRVTDLQESWKIVNVDYKTEILYGLCELEFTLLAVIVNCIAKRESD-VNFEMVYREYNEFCKTSYSNSY--DKNVLRKCLDHLLDLDLVGMKKG 1210
            +S + + LR++++  + + FG ++    ++  +K   +HGESNS +IIG RGSGK+ L+K  L ++   ++ ++N  QV LNGLL T DK ALK I  QL    +EN   +    +F EN  ++L  L +GDR S C +  +++EFDLF  H NQ L+YN+ +  QS  TP+ V+G T RLD++EL+EKRVKSRFSH QI ++    F   ++++ E   KL   ++  +S+  ++WN++     ND      +  +F+   L  QL     + + R+S +   +   D  E +++ N D K  I++GL  LE  L+  + +     + +  NF+MV+ E+ +F +    + Y  +K V+ K  +HL  L+L+   +G
Sbjct:   17 ISRVHAILRQRLFQHHGKPFGVDSQHKHLVELLKRTVVHGESNSALIIGPRGSGKSMLLKGALEEILAMKQVKENALQVRLNGLLQTTDKIALKEITRQLH---LENVVGDRVFGSFAENLAFLLEALKTGDRKSSCPVLLLLDEFDLFAHHKNQTLLYNLFDIAQSAQTPVAVIGLTCRLDVMELLEKRVKSRFSHRQIHLLNSFSFIQYLEIFQE---KLFLPASFPDSQFAEKWNETHFLSHNDPIYYNTIFGHFLRPCLYYQL-----LAVCRVSVSHPHITAADFLEVFRLRNQDSKANIMHGLSVLELCLIIAMKHLQDIYDGEPFNFQMVHNEFQKFIQRKAHSVYNFEKPVVMKAFEHLHQLELIKPMEG 383
[Close]
BLAST of Origin recognition complex subunit 4 vs. Ensembl Mouse
Match: Orc4 (origin recognition complex, subunit 4 [Source:MGI Symbol;Acc:MGI:1347043])

HSP 1 Score: 209.92 bits (533), Expect = 1.322e-62
Identity = 141/393 (35.88%), Postives = 224/393 (57.00%), Query Frame = 2 
Query:   80 NMNSNFMSDIVSPLRRKI--YSSNHEFFGYENYESRIIPSIKNAYIHGESNSMMIIGKRGSGKTHLIKSLLNDLNNDEKFRDNVYQVNLNGLLHTDDKCALKSIAFQLKCHLIENEEEEFTSDNFNENFEYILSFLTSGDRNSICXXXXXXXXXXXXQHT-NQILIYNILNCVQSKGTPIFVLGTTTRLDILELMEKRVKSRFSHCQISMIPFGTTIDL--YVESMRKLLTISNE-ANSKLIQRWNDSVKRFSNDSNVLKVLERNFMLSNLIGQLKRLLMIPISRLSSTDVELRVTDLQESWKIVNVDYKTEILYGLCELEFTLLAVI--VNCIAKRESDVNFEMVYREYNEFCKTSYSNSY--DKNVLRKCLDHLLDLDLVGMKKGKTGNSN 1228
            N ++  +S +   LR +   +S +   FG +     +I  +K   I+GESNS++I+G RGSGKT L+   L +L   E   +NV QV+LNGLL T++K ALK I  QL    ++N  E+    +F EN  ++L  L  GDR S C +  I +      H  NQ L+YN+ +  QS  TP+ V+G T RLDILEL+EKRVKSRFSH QI ++    + D   Y++  ++ L++  E  +    +RWN++V   S DS VL+VL+++F ++  +  L  LLM+ ++R++ +   +   DL E+  + ++D K  I++GL  LE  L+  +  +N I + E   NF+MVY E+ +F +    + Y  +K V+ K  +HL  L+L+   +  + NS 
Sbjct:    9 NAHAECLSQVQRILRERFCHHSPHSNLFGVQVQYKHLIELLKRTAIYGESNSVLIVGPRGSGKTTLLNHALKELMEIE-VSENVIQVHLNGLLQTNEKIALKEITRQLN---LDNVVEDKVFGSFAENLSFLLEALQKGDRTSSCPVIFILDEFDIFAHQKNQTLLYNLFDISQSAQTPVAVIGLTCRLDILELLEKRVKSRFSHRQIHLM---NSFDFPQYLKIFKEQLSLPAEFPDKAFAERWNENVHCLSEDSTVLEVLQKHFSVNKNLQSLHMLLMLALNRVTVSHPFMTSADLMEAQHMCSLDSKANIVHGLSVLEICLIIAMKHLNDIYEEEP-FNFQMVYNEFQKFIQRKAHSVYNFEKPVVMKAFEHLQQLELIKPVERTSVNSQ 393
[Close]
BLAST of Origin recognition complex subunit 4 vs. Ensembl Mouse
Match: Orc4 (origin recognition complex, subunit 4 [Source:MGI Symbol;Acc:MGI:1347043])

HSP 1 Score: 143.665 bits (361), Expect = 1.199e-39
Identity = 89/211 (42.18%), Postives = 125/211 (59.24%), Query Frame = 2 
Query:   80 NMNSNFMSDIVSPLRRKI--YSSNHEFFGYENYESRIIPSIKNAYIHGESNSMMIIGKRGSGKTHLIKSLLNDLNNDEKFRDNVYQVNLNGLLHTDDKCALKSIAFQLKCHLIENEEEEFTSDNFNENFEYILSFLTSGDRNSICXXXXXXXXXXXXQHT-NQILIYNILNCVQSKGTPIFVLGTTTRLDILELMEKRVKSRFSHCQISMI 703
            N ++  +S +   LR +   +S +   FG +     +I  +K   I+GESNS++I+G RGSGKT L+   L +L   E   +NV QV+LNGLL T++K ALK I  QL    ++N  E+    +F EN  ++L  L  GDR S C +  I +      H  NQ L+YN+ +  QS  TP+ V+G T RLDILEL+EKRVKSRFSH QI ++
Sbjct:    9 NAHAECLSQVQRILRERFCHHSPHSNLFGVQVQYKHLIELLKRTAIYGESNSVLIVGPRGSGKTTLLNHALKELMEIE-VSENVIQVHLNGLLQTNEKIALKEITRQLN---LDNVVEDKVFGSFAENLSFLLEALQKGDRTSSCPVIFILDEFDIFAHQKNQTLLYNLFDISQSAQTPVAVIGLTCRLDILELLEKRVKSRFSHRQIHLM 215
[Close]
BLAST of Origin recognition complex subunit 4 vs. Ensembl Mouse
Match: Orc4 (origin recognition complex, subunit 4 [Source:MGI Symbol;Acc:MGI:1347043])

HSP 1 Score: 73.9442 bits (180), Expect = 2.317e-15
Identity = 44/108 (40.74%), Postives = 64/108 (59.26%), Query Frame = 2 
Query:   80 NMNSNFMSDIVSPLRRKI--YSSNHEFFGYENYESRIIPSIKNAYIHGESNSMMIIGKRGSGKTHLIKSLLNDLNNDEKFRDNVYQVNLNGLLHTDDKCALKSIAFQL 397
            N ++  +S +   LR +   +S +   FG +     +I  +K   I+GESNS++I+G RGSGKT L+   L +L   E   +NV QV+LNGLL T++K ALK I  QL
Sbjct:    9 NAHAECLSQVQRILRERFCHHSPHSNLFGVQVQYKHLIELLKRTAIYGESNSVLIVGPRGSGKTTLLNHALKELMEIE-VSENVIQVHLNGLLQTNEKIALKEITRQL 115
[Close]
BLAST of Origin recognition complex subunit 4 vs. UniProt/SwissProt
Match: sp|O43929|ORC4_HUMAN (Origin recognition complex subunit 4 OS=Homo sapiens OX=9606 GN=ORC4 PE=1 SV=2)

HSP 1 Score: 220.32 bits (560), Expect = 1.436e-65
Identity = 146/371 (39.35%), Postives = 220/371 (59.30%), Query Frame = 2 
Query:  137 SSNHEFFGYENYESRIIPSIKNAYIHGESNSMMIIGKRGSGKTHLIKSLLNDLNNDEKFRDNVYQVNLNGLLHTDDKCALKSIAFQLKCHLIENEEEEFTSDNFNENFEYILSFLTSGDRNSICXXXXXX-XXXXXXQHTNQILIYNILNCVQSKGTPIFVLGTTTRLDILELMEKRVKSRFSHCQISMI-PFGTTIDLYVESMRKLLTISNEANSKLI-QRWNDSVKRFSNDSNVLKVLERNFMLSNLIGQLKRLLMIPISRLSSTDVELRVTDLQESWKIVNVDYKTEILYGLCELEFTLLAVI--VNCIAKRESDVNFEMVYREYNEFCKTSYSNSY--DKNVLRKCLDHLLDLDLVGMKKGKTGNSN 1228
            S +   FG +     +   +K   +HGESNS++IIG RGSGKT LI   L +L   E+  +NV QV+LNGLL  +DK ALK I  QL    +EN   +    +F EN  ++L  L  GDR S C +  I  EFDLF  H NQ L+YN+ +  QS  TPI V+G T RLDILEL+EKRVKSRFSH QI ++  FG     YV+  ++ L++  E   K+  ++WN++V+  S D +V +VL+++F +S  +  L  LLM+ ++R++++   +   DL E+ ++ ++D K  I++GL  LE  L+  +  +N I + E   NF+MVY E+ +F +    + Y  +K V+ K  +HL  L+L+   +  +GNS 
Sbjct:   32 SPHSNLFGVQVQYKHLSELLKRTALHGESNSVLIIGPRGSGKTMLINHALKELMEIEEVSENVLQVHLNGLLQINDKIALKEITRQLN---LENVVGDKVFGSFAENLSFLLEALKKGDRTSSCPVIFILDEFDLFAHHKNQTLLYNLFDISQSAQTPIAVIGLTCRLDILELLEKRVKSRFSHRQIHLMNSFG--FPQYVKIFKEQLSLPAEFPDKVFAEKWNENVQYLSEDRSVQEVLQKHFNISKNLRSLHMLLMLALNRVTASHPFMTAVDLMEASQLCSMDSKANIVHGLSVLEICLIIAMKHLNDIYEEEP-FNFQMVYNEFQKFVQRKAHSVYNFEKPVVMKAFEHLQQLELIKPMERTSGNSQ 396
[Close]
BLAST of Origin recognition complex subunit 4 vs. UniProt/SwissProt
Match: sp|Q5R6Z7|ORC4_PONAB (Origin recognition complex subunit 4 OS=Pongo abelii OX=9601 GN=ORC4 PE=2 SV=1)

HSP 1 Score: 218.779 bits (556), Expect = 5.122e-65
Identity = 149/386 (38.60%), Postives = 229/386 (59.33%), Query Frame = 2 
Query:   98 MSDIVSPLRRKI-YSSNHE-FFGYENYESRIIPSIKNAYIHGESNSMMIIGKRGSGKTHLIKSLLNDLNNDEKFRDNVYQVNLNGLLHTDDKCALKSIAFQLKCHLIENEEEEFTSDNFNENFEYILSFLTSGDRNSICXXX-XXXXXXXXXQHTNQILIYNILNCVQSKGTPIFVLGTTTRLDILELMEKRVKSRFSHCQISMI-PFGTTIDLYVESMRKLLTISNEANSKLI-QRWNDSVKRFSNDSNVLKVLERNFMLSNLIGQLKRLLMIPISRLSSTDVELRVTDLQESWKIVNVDYKTEILYGLCELEFTLLAVI--VNCIAKRESDVNFEMVYREYNEFCKTSYSNSY--DKNVLRKCLDHLLDLDLVGMKKGKTGNSN 1228
            +S +   LR +  + S H   FG +     +   +K   +HGESNS++IIG RGSGKT LI   L +L   E+  +NV QV+LNGLL  +DK ALK I  QL    +EN   +    +F EN  ++L  L  GDR S C +  I++EFDLF  H NQ L+YN+ +  QS  TP+ V+G T RLDILEL+EKRVKSRFSH QI ++  FG     YV+  ++ L++  E   K+  ++WN++V+  S D +V +VL+++F +S  +  L  LLM+ ++R++++   +   DL E+ ++ ++D K  I++GL  LE  L+  +  +N I + E   NF+MVY E+ +F +    + Y  +K V+ K  +HL  L+L+   +  +GNS 
Sbjct:   17 LSQVQRILRERFCHQSPHSNLFGVQVQYKHLSELLKRTALHGESNSVLIIGPRGSGKTMLINHALKELMEIEEVSENVLQVHLNGLLQINDKIALKEITRQLN---LENVVGDKVFGSFAENLSFLLEALKKGDRTSSCPVVFILDEFDLFAHHKNQTLLYNLFDISQSAQTPVAVIGLTCRLDILELLEKRVKSRFSHRQIHLMNSFG--FPQYVKIFKEQLSLPAEFPDKVFAEKWNENVQYLSEDRSVQEVLQKHFNISKNLRSLHMLLMLALNRVTASHPFMTAVDLIEASQLCSMDSKANIVHGLSVLEICLIIAMKHLNDIYEEEP-FNFQMVYNEFQKFVQRKAHSVYNFEKPVVMKAFEHLQQLELIKPMERTSGNSQ 396
[Close]
BLAST of Origin recognition complex subunit 4 vs. UniProt/SwissProt
Match: sp|Q2YDI2|ORC4_BOVIN (Origin recognition complex subunit 4 OS=Bos taurus OX=9913 GN=ORC4 PE=2 SV=1)

HSP 1 Score: 212.616 bits (540), Expect = 1.049e-62
Identity = 143/381 (37.53%), Postives = 220/381 (57.74%), Query Frame = 2 
Query:   83 MNSNFMSDIVSPLRRKI-YSSNH-EFFGYENYESRIIPSIKNAYIHGESNSMMIIGKRGSGKTHLIKSLLNDLNNDEKFRDNVYQVNLNGLLHTDDKCALKSIAFQLKCHLIENEEEEFTSDNFNENFEYILSFLTSGDRNSICXXXXXX-XXXXXXQHTNQILIYNILNCVQSKGTPIFVLGTTTRLDILELMEKRVKSRFSHCQISMI---PFGTTIDLYVESMRKLLTISNEANSKLIQRWNDSVKRFSNDSNVLKVLERNFMLSNLIGQLKRLLMIPISRLSSTDVELRVTDLQESWKIVNVDYKTEILYGLCELEFTLLAVI--VNCIAKRESDVNFEMVYREYNEFCKTSYSNSY--DKNVLRKCLDHLLDLDLV 1195
            + ++++S +   LR +  + S H   FG +     +I  +K   IHGESNS++IIG RGSGKT LI   L +L   E   +N+ QV+LNGLL  +DK ALK I  QL    +EN   +    +F EN  ++L  L  GDR S C +  I  EFDLF  H NQ L+YN+L+  QS  TP+ ++G T RLDILEL+EKRVKSRFSH QI ++    F   + ++ E +        E      ++WN++V+  S D +V +VL+++F +S  +  L  LLM+ ++R++ +   +   DL E+ ++ ++D K  I++GL  LE  L+  +  +N I + E   NF+MVY E+ +F +    + Y  +K V+ K  +HL  L+L+
Sbjct:   12 IQADYISQVQRILRERFCHQSPHGNLFGVQVQYKHLIELLKRTAIHGESNSILIIGPRGSGKTMLINHALKELMEIEGVSENILQVHLNGLLQINDKIALKEITRQLN---LENVVGDKVFGSFAENLSFLLEALKKGDRTSSCPVIFILDEFDLFAHHKNQTLLYNLLDISQSAQTPVVIIGLTCRLDILELLEKRVKSRFSHRQIHLMNSFSFPQYLKIFKEQLSLPSVFPEEI---FAEKWNENVQSLSEDRSVKEVLQKHFNVSKNLRSLHMLLMLALNRVTPSHPFITAADLMEANQLCSMDSKGNIVHGLSVLEICLIIAMKHLNDIYEEEP-FNFQMVYNEFQKFVQRKAHSVYNFEKPVVMKAFEHLQQLELI 385
[Close]
BLAST of Origin recognition complex subunit 4 vs. UniProt/SwissProt
Match: sp|Q6P9Z8|ORC4_RAT (Origin recognition complex subunit 4 OS=Rattus norvegicus OX=10116 GN=Orc4 PE=2 SV=1)

HSP 1 Score: 210.69 bits (535), Expect = 5.301e-62
Identity = 140/392 (35.71%), Postives = 223/392 (56.89%), Query Frame = 2 
Query:   80 NMNSNFMSDIVSPLRRKI--YSSNHEFFGYENYESRIIPSIKNAYIHGESNSMMIIGKRGSGKTHLIKSLLNDLNNDEKFRDNVYQVNLNGLLHTDDKCALKSIAFQLKCHLIENEEEEFTSDNFNENFEYILSFLTSGDRNSICXXXXXXXXXXXXQHT-NQILIYNILNCVQSKGTPIFVLGTTTRLDILELMEKRVKSRFSHCQISMIPFGTTIDL--YVESMRKLLTISNEANSKLI-QRWNDSVKRFSNDSNVLKVLERNFMLSNLIGQLKRLLMIPISRLSSTDVELRVTDLQESWKIVNVDYKTEILYGLCELEFTLLAVI--VNCIAKRESDVNFEMVYREYNEFCKTSYSNSY--DKNVLRKCLDHLLDLDLVGMKKGKTGNS 1225
            N+++  +S +   LR +   ++ +   FG +     +I  +K   I+GESNS++I+G RGSGKT L+   L +L       +NV QV+LNGLL T+DK ALK I  QL    +EN   +    +F EN  ++L  L  G+R S C +  I +      H  NQ L+YN+ +  QS  TPI V+G T RLDILEL+EKRVKSRFSH QI ++    + D   Y++  ++ L++  E   K+  ++WN++    S DS VL+VL+++F ++  +  L  LLM+ ++R++ T   +   DL E+  + ++D K  I++GL  LE  L+  +  +N I + E   NF+MVY E+ +F +    + Y  +K V+ K  +HL  L+L+   +  + NS
Sbjct:    9 NIHAECLSQVQRILRERFCHHTPHSNLFGVQVQYKHLIELLKRTAIYGESNSLLIVGPRGSGKTTLLNHALKELMQIGDMSENVLQVHLNGLLQTNDKIALKEITRQLN---LENVVGDKVFGSFAENLSFLLEALQKGNRTSSCPVIFILDEFDLFAHQKNQTLLYNLFDISQSAQTPIAVIGLTCRLDILELLEKRVKSRFSHRQIHLM---NSFDFPQYLKIFKEQLSLPAEFPDKIFAEKWNENAHCLSEDSTVLEVLQKHFNVNKNLQSLHMLLMLALNRVTVTHPFMTSADLMEAQHLCSLDAKASIVHGLSVLEICLIIAMKHLNDIYEEEP-FNFQMVYNEFQKFIQRKAHSVYNFEKPVVMKAFEHLQQLELIKPMERTSVNS 393
[Close]
BLAST of Origin recognition complex subunit 4 vs. UniProt/SwissProt
Match: sp|O93479|ORC4_XENLA (Origin recognition complex subunit 4 OS=Xenopus laevis OX=8355 GN=orc4 PE=2 SV=1)

HSP 1 Score: 210.305 bits (534), Expect = 7.616e-62
Identity = 131/378 (34.66%), Postives = 215/378 (56.88%), Query Frame = 2 
Query:   98 MSDIVSPLRRKIYSSNHEFFGYENYESRIIPSIKNAYIHGESNSMMIIGKRGSGKTHLIKSLLNDLNNDEKFRDNVYQVNLNGLLHTDDKCALKSIAFQLKCHLIENEEEEFTSDNFNENFEYILSFLTSGDRNSICXXXXXX-XXXXXXQHTNQILIYNILNCVQSKGTPIFVLGTTTRLDILELMEKRVKSRFSHCQISMI---PFGTTIDLYVESMRKLLTISNEANSKLIQRWNDSVKRFSNDSNVLKVLERNFMLSNLIGQLKRLLMIPISRLSSTDVELRVTDLQESWKIVNVDYKTEILYGLCELEFTLLAVIVNCIAKRESD-VNFEMVYREYNEFCKTSYSNSY--DKNVLRKCLDHLLDLDLVGMKKG 1210
            +S +   LR++++  + + FG ++    ++  +K   IHGESNS +IIG RGSGK+ L+K  L D+   ++ ++   QVNLNGLL T DK ALK I  QL    +EN   +    +F EN  ++L  L +GDR S C +  +  EFDLF  H NQ L+YN+ +  QS  TP+ V+G T RLD++EL+EKRVKSRFSH QI ++    F   + ++ E   KL   ++  +S+  ++WN+S+K       V  VL++ +  S  +  L  L+++ + R++ +   +   D  E +++ N D K  IL+G+  LE  L+  + +     + +  NF+MV+ E+ +F +    + Y  +K V+ K  +HL  L+L+   +G
Sbjct:   17 ISKVHGILRQRLFQHHGKPFGVDSQHKHLVELLKRTVIHGESNSALIIGPRGSGKSMLLKGALEDIFGMKQMKETALQVNLNGLLQTTDKIALKEITRQLH---LENVVGDRVFGSFAENLSFLLEALKTGDRKSSCPVLFVLDEFDLFAHHKNQTLLYNLFDIAQSAQTPVAVIGLTCRLDVMELLEKRVKSRFSHRQIHLLNSFSFSQYLQIFQE---KLSLPASFPDSQFAEKWNESIKSLVESKLVEDVLQKQYNASKDVRSLHMLMLLAVCRVNVSHPHITAADFLEVFRLRNQDSKANILHGVSVLELCLIIAMKHLQDIYDGEPFNFQMVHNEFQKFIQRKAHSVYNFEKAVVIKAFEHLHQLELIKPMEG 388
[Close]
BLAST of Origin recognition complex subunit 4 vs. TrEMBL
Match: R7VC25 (Origin recognition complex subunit 4 OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_227802 PE=3 SV=1)

HSP 1 Score: 232.646 bits (592), Expect = 4.841e-68
Identity = 154/408 (37.75%), Postives = 236/408 (57.84%), Query Frame = 2 
Query:   83 MNSNFMSDIVSPLRRKIYSSNHEFFGY-ENYESRIIPSIKNAYIHGESNSMMIIGKRGSGKTHLIKSLLNDLNNDEKFRDNVYQVNLNGLLHTDDKCALKSIAFQLKCHLIENEEEEFTSDNFNENFEYILSFLTSG-DRNSICXXXXXXXXXXXXQHTNQILIYNILNCVQSKGTPIFVLGTTTRLDILELMEKRVKSRFSHCQISMIPFGTTIDLYVESMRKLLTISNE-ANSKLIQRWNDSVKRFSNDSNVLKVLERNFMLSNLIGQLKRLLMIPISRLSSTDVELRVTDLQESWKIVNVDYKTEILYGLCELEFTLLAVI--VNCIAKRESDVNFEMVYREYNEFCKTSYSNSYDKNVLRKCLDHLLDLDLVGMKKGKTGNSN--FNPFQCFILHRDLAECVKR 1285
            M  +F+S + + LR+++    H    + EN   ++   +      GESNS+++IG RGSGK+ L++ +L+DL N++    N+  V LNGLL TDDK AL  I  QL+   +E E E     +F EN +++L  L SG DR S  L+F+++EFDLF  H NQ L+YN+ +  QS   PI V+G T R+D+LEL+EKRVKSRFSH  I ++P       Y+E  + +LT+  + A+ KL+  WN S + F  DS+V+ VL++ F L   I  L +LLMIP+ +L++   +L  +DL  S+KI++ D K  +L G+  LE TL+  +  +N +   E   NFEMV+  Y +F + +   S+ K V+ K  +HL  L++V   +  T  +   F   +       + E VKR
Sbjct:    1 MEEDFISSVQTLLRQRLCGKCHNQLRFRENEIKQLHDLVHRTATVGESNSLLVIGPRGSGKSTLLEGVLDDLTNEKDVTGNILVVRLNGLLQTDDKIALAEITRQLQ---LEAESEGKAFGSFAENLQFLLEALRSGSDRKSRSLVFVLDEFDLFAHHRNQTLLYNLFDVAQSAQAPICVIGLTVRMDVLELLEKRVKSRFSHRFIHLLP-TYEFKEYLEIAQDVLTLPQDFASKKLVGDWNKSAQEFMQDSSVIDVLQQIFYLDKSIQHLYQLLMIPVCKLNAEHTKLLASDLYASFKILHKDDKAAMLQGVSILELTLVLAMKHLNEVYDGEP-FNFEMVFSVYKKFTQRAALQSFQKAVVIKAFEHLCSLEIVRAAESSTSRTQREFRALRLMADSSQIMEAVKR 403
[Close]
BLAST of Origin recognition complex subunit 4 vs. TrEMBL
Match: A0A250Y0V5 (Origin recognition complex subunit 4 OS=Castor canadensis OX=51338 GN=ORC4 PE=3 SV=1)

HSP 1 Score: 225.713 bits (574), Expect = 3.676e-65
Identity = 151/370 (40.81%), Postives = 224/370 (60.54%), Query Frame = 2 
Query:  137 SSNHEFFGYENYESRIIPSIKNAYIHGESNSMMIIGKRGSGKTHLIKSLLNDLNNDEKFRDNVYQVNLNGLLHTDDKCALKSIAFQLKCHLIENEEEEFTSDNFNENFEYILSFLTSGDRNSICXXX-XXXXXXXXXQHTNQILIYNILNCVQSKGTPIFVLGTTTRLDILELMEKRVKSRFSHCQISMI-PFGTTIDLYVESMRKLLTISNEANSKLI-QRWNDSVKRFSNDSNVLKVLERNFMLSNLIGQLKRLLMIPISRLSSTDVELRVTDLQESWKIVNVDYKTEILYGLCELEFTLLAVI--VNCIAKRESDVNFEMVYREYNEFCKTSYSNSY--DKNVLRKCLDHLLDLDLVGMKKGKTGNS 1225
            S N   FG +     +I  +K   IHGESNS++IIG RGSGKT LI   L +L + E+ R+NV QV+LNGLL  +DK ALK I  QL    +EN   +    +F EN  ++L  L  GDR S C +  I++EFDLF  H NQ L+YN+ +  QS  TP+ V+G T RLDILEL+EKRVKSRFSH QI +I  FG     YV+  ++ L++  E   KL  ++WN++V+  S D +V +VL+R+F +S  +  L  LLM+ ++R++++   +   DL E+ ++ ++D K  I++GL  LE  L+  +  +N I + E   NF+MVY E+ +F +    + Y  +K V+ K  +HL  L+L+   +  + NS
Sbjct:   32 SPNSNLFGVQVQYKHLIELLKRTAIHGESNSVLIIGPRGSGKTLLINHALKELMDIEEVRENVLQVHLNGLLQINDKIALKEITRQLS---LENVVGDKVFGSFAENLSFLLDALQKGDRTSSCPVIFILDEFDLFAHHKNQTLLYNLFDISQSAQTPVAVIGLTCRLDILELLEKRVKSRFSHRQIHLINSFG--FPQYVKIFKEQLSLPAEFPDKLFAEKWNENVQCLSEDGSVREVLQRHFNVSKNLRSLHMLLMLALNRVTASHPFMTSADLMEANQLCSMDSKANIVHGLSVLEICLIIAMKHLNDIYEEEP-FNFQMVYNEFQKFVQRKAHSVYNFEKPVVMKAFEHLQQLELIKPMERTSVNS 395
[Close]
BLAST of Origin recognition complex subunit 4 vs. TrEMBL
Match: G1P755 (Origin recognition complex subunit 4 OS=Myotis lucifugus OX=59463 GN=ORC4 PE=3 SV=1)

HSP 1 Score: 223.402 bits (568), Expect = 2.330e-64
Identity = 151/380 (39.74%), Postives = 227/380 (59.74%), Query Frame = 2 
Query:   83 MNSNFMSDIVSPLRRKI-YSSNHE-FFGYENYESRIIPSIKNAYIHGESNSMMIIGKRGSGKTHLIKSLLNDLNNDEKFRDNVYQVNLNGLLHTDDKCALKSIAFQLKCHLIENEEEEFTSDNFNENFEYILSFLTSGDRNSICXXXXXX-XXXXXXQHTNQILIYNILNCVQSKGTPIFVLGTTTRLDILELMEKRVKSRFSHCQISMI-PFGTTIDLYVESMRKLLTISNEANSKLI-QRWNDSVKRFSNDSNVLKVLERNFMLSNLIGQLKRLLMIPISRLSSTDVELRVTDLQESWKIVNVDYKTEILYGLCELEFTLLAVI--VNCIAKRESDVNFEMVYREYNEFCKTSYSNSY--DKNVLRKCLDHLLDLDLV 1195
            +++ ++S +   LR +  Y S+H   FG +     +I  +K   IHGESNS++IIG RGSGKT LI   L +L   E   +NV QV+LNGLL  +DK ALK I  QL    +EN   +    +F EN  +IL  L  GDR S C +  I  EFDLF  H NQ L+YN+ +  QS  TPI V+G T RLDILEL+EKRVKSRFSH Q+ ++  FG     Y++  ++ L++  E   KL  ++WN++V+  S D +V +VL+++F +S  +  L  LLM+ +SR++++   +   DL E+ ++ ++D K  I++GL  LE  L+  +  +N I + E   NF+MVY E+ +F +    + Y  +K V+ K  +HL  L+L+
Sbjct:   12 IHTEYLSQVQRILRERFCYQSSHSNLFGLQVQYKHLIELLKRTAIHGESNSVLIIGPRGSGKTMLINHALKELMEVEDVSENVLQVHLNGLLQINDKIALKEITRQLN---LENVVGDKVFGSFAENLSFILEALKKGDRTSSCPVIFILDEFDLFAHHRNQTLLYNLFDISQSAQTPIAVIGLTCRLDILELLEKRVKSRFSHRQMHLMNSFG--FPQYLKIFKEQLSLPAEFPDKLFAEKWNENVQCLSEDKSVQEVLQKHFNVSKSLRSLHMLLMLALSRVTTSHPFITAADLMEANQLCSMDSKANIVHGLSVLEICLIIAMKHLNDIYEEEP-FNFQMVYNEFQKFVQRKAHSVYNFEKPVVMKAFEHLQQLELI 385
[Close]
BLAST of Origin recognition complex subunit 4 vs. TrEMBL
Match: A0A5F8A651 (Origin recognition complex subunit 4 OS=Macaca mulatta OX=9544 GN=ORC4 PE=3 SV=1)

HSP 1 Score: 221.861 bits (564), Expect = 6.380e-64
Identity = 152/386 (39.38%), Postives = 227/386 (58.81%), Query Frame = 2 
Query:   98 MSDIVSPLRRKI-YSSNHE-FFGYENYESRIIPSIKNAYIHGESNSMMIIGKRGSGKTHLIKSLLNDLNNDEKFRDNVYQVNLNGLLHTDDKCALKSIAFQLKCHLIENEEEEFTSDNFNENFEYILSFLTSGDRNSICXXXXXX-XXXXXXQHTNQILIYNILNCVQSKGTPIFVLGTTTRLDILELMEKRVKSRFSHCQISMI-PFGTTIDLYVESMRKLLTISNEANSKLI-QRWNDSVKRFSNDSNVLKVLERNFMLSNLIGQLKRLLMIPISRLSSTDVELRVTDLQESWKIVNVDYKTEILYGLCELEFTLLAVI--VNCIAKRESDVNFEMVYREYNEFCKTSYSNSY--DKNVLRKCLDHLLDLDLVGMKKGKTGNSN 1228
            M ++   LR +  + S H   FG +     I   +K   +HGESNS++IIG RGSGKT LI   L +L   E+  +NV QV+LNGLL  +DK ALK I  QL    +EN   +    +F EN  ++L  L  GDR S C +  I  EFDLF  H NQ L+YN+ +  QS  TPI V+G T RLDILEL+EKRVKSRFSH QI ++  FG     YV+  ++ L++  E   KL  ++WN++V+  S D +V +VL+++F +S  +  L  LLM+ ++R++++   +   DL E+ ++ ++D K  I++GL  LE  L+  +  +N I + E   NF+MVY E+ +F +    + Y  +K V+ K  +HL  L+L+   +  +GNS 
Sbjct:    1 MREVQRILRERFCHQSPHSNLFGVQVQYKHISELLKRTALHGESNSVLIIGPRGSGKTMLINHALKELMEIEEVSENVLQVHLNGLLQINDKIALKEITRQLN---LENVVGDKVFGSFAENLSFLLEALKKGDRTSSCPVIFILDEFDLFAHHKNQTLLYNLFDISQSAQTPIAVIGLTCRLDILELLEKRVKSRFSHRQIHLMNSFG--FPQYVKIFKEQLSLPAEFPDKLFAEKWNENVQYLSEDRSVQEVLQKHFNISKNLRSLHMLLMLTLNRVTASHPFMTAIDLMEASQLCSMDSKANIVHGLSVLEICLIIAMKHLNDIYEEEP-FNFQMVYNEFQKFVQRKAHSVYNFEKPVVMKAFEHLQQLELIKPMERTSGNSQ 380
[Close]
BLAST of Origin recognition complex subunit 4 vs. TrEMBL
Match: A0A2K6BS71 (Origin recognition complex subunit 4 OS=Macaca nemestrina OX=9545 GN=ORC4 PE=3 SV=1)

HSP 1 Score: 221.861 bits (564), Expect = 8.773e-64
Identity = 152/386 (39.38%), Postives = 227/386 (58.81%), Query Frame = 2 
Query:   98 MSDIVSPLRRKI-YSSNHE-FFGYENYESRIIPSIKNAYIHGESNSMMIIGKRGSGKTHLIKSLLNDLNNDEKFRDNVYQVNLNGLLHTDDKCALKSIAFQLKCHLIENEEEEFTSDNFNENFEYILSFLTSGDRNSICXXXXXX-XXXXXXQHTNQILIYNILNCVQSKGTPIFVLGTTTRLDILELMEKRVKSRFSHCQISMI-PFGTTIDLYVESMRKLLTISNEANSKLI-QRWNDSVKRFSNDSNVLKVLERNFMLSNLIGQLKRLLMIPISRLSSTDVELRVTDLQESWKIVNVDYKTEILYGLCELEFTLLAVI--VNCIAKRESDVNFEMVYREYNEFCKTSYSNSY--DKNVLRKCLDHLLDLDLVGMKKGKTGNSN 1228
            +S +   LR +  + S H   FG +     I   +K   +HGESNS++IIG RGSGKT LI   L +L   E+  +NV QV+LNGLL  +DK ALK I  QL    +EN   +    +F EN  ++L  L  GDR S C +  I  EFDLF  H NQ L+YN+ +  QS  TPI V+G T RLDILEL+EKRVKSRFSH QI ++  FG     YV+  ++ L++  E   KL  ++WN++V+  S D +V +VL+++F +S  +  L  LLM+ ++R++++   +   DL E+ ++ ++D K  I++GL  LE  L+  +  +N I + E   NF+MVY E+ +F +    + Y  +K V+ K  +HL  L+L+   +  +GNS 
Sbjct:   17 LSQVQRILRERFCHQSPHSNLFGVQVQYKHISELLKRTALHGESNSVLIIGPRGSGKTMLINHALKELMEIEEVSENVLQVHLNGLLQINDKIALKEITRQLN---LENVVGDKVFGSFAENLSFLLEALKKGDRTSSCPVIFILDEFDLFAHHKNQTLLYNLFDISQSAQTPIAVIGLTCRLDILELLEKRVKSRFSHRQIHLMNSFG--FPQYVKIFKEQLSLPAEFPDKLFAEKWNENVQYLSEDRSVQEVLQKHFNISKNLRSLHMLLMLTLNRVTASHPFMTAIDLMEASQLCSMDSKANIVHGLSVLEICLIIAMKHLNDIYEEEP-FNFQMVYNEFQKFVQRKAHSVYNFEKPVVMKAFEHLQQLELIKPMERTSGNSQ 396
[Close]
BLAST of Origin recognition complex subunit 4 vs. Ensembl Cavefish
Match: orc4 (origin recognition complex subunit 4 [Source:NCBI gene;Acc:103040073])

HSP 1 Score: 198.364 bits (503), Expect = 3.526e-58
Identity = 138/353 (39.09%), Postives = 220/353 (62.32%), Query Frame = 2 
Query:  155 FGYENYESRIIPSIKNAYIHGESNSMMIIGKRGSGKTHLIKSLLNDLNNDEKFRDNVYQVNLNGLLHTDDKCALKSIAFQLKCHLIENEEEEFTSDNFNENFEYILSFLTSGDRNSI-CXXXXXXXXXXXXQHTNQILIYNILNCVQSKGTPIFVLGTTTRLDILELMEKRVKSRFSHCQISMIPFGTTIDLYVESMRKLLTISNE-ANSKLIQRWNDSVKRFSNDSNVLKVLERNFMLSNLIGQLKRLLMIPISRLSSTDVELRVTDLQESWKIVNVDYKTEILYGLCELEFTLLAVI--VNCIAKRESDVNFEMVYREYNEFC-KTSYS-NSYDKNVLRKCLDHLLDLDLV 1195
            +G ++    ++  ++   +HGESNS++I+G RG+GKT L++  L +L   ++ + NV QV+L+GLL TDD+ ALK I  QL  HL EN   +    +F EN  ++L  L  GD++S   + FI++EFDLF  H NQ L+YN+L+  QS   P+ V+G T RLD+LEL+EKRVKSRFSH QI ++    T   Y E+ R  LT+ +   +SK  Q WN S+K+   D +V ++L+++F  S     L  LL++ +SR+S ++  ++  D+ E+ ++   D K  IL+GL  LE  L+  +  +N I + E   NF+MV+ E+ +F  + S+S ++++K V+ K  +HLL L+L+
Sbjct:   38 YGLDSQYKHLLELLRRTAVHGESNSVLIVGPRGAGKTMLLRCALRELLELQEVKKNVLQVHLSGLLQTDDRIALKEITRQL--HL-ENVVGDKVFGSFAENLVFLLEALKKGDKSSSRPVFFILDEFDLFAHHKNQTLLYNLLDVSQSAQAPVAVVGLTCRLDMLELLEKRVKSRFSHRQIHLLS-SMTFPQYQETFRSELTLPDTFPDSKFSQEWNLSIKKLCEDKSVEEILQKSFNCSKDFRSLHLLLLLALSRVSVSNPTVQAADILEANRMSAADSKANILHGLSILELCLIIAMKHLNDIYEGEP-FNFQMVHNEFKKFIQRKSHSIHNFEKPVVIKAFEHLLQLELI 385
[Close]
BLAST of Origin recognition complex subunit 4 vs. Ensembl Cavefish
Match: orc4 (origin recognition complex subunit 4 [Source:NCBI gene;Acc:103040073])

HSP 1 Score: 182.956 bits (463), Expect = 9.845e-53
Identity = 128/353 (36.26%), Postives = 204/353 (57.79%), Query Frame = 2 
Query:  155 FGYENYESRIIPSIKNAYIHGESNSMMIIGKRGSGKTHLIKSLLNDLNNDEKFRDNVYQVNLNGLLHTDDKCALKSIAFQLKCHLIENEEEEFTSDNFNENFEYILSFLTSGDRNSI-CXXXXXXXXXXXXQHTNQILIYNILNCVQSKGTPIFVLGTTTRLDILELMEKRVKSRFSHCQISMIPFGTTIDLYVESMRKLLTISNE-ANSKLIQRWNDSVKRFSNDSNVLKVLERNFMLSNLIGQLKRLLMIPISRLSSTDVELRVTDLQESWKIVNVDYKTEILYGLCELEFTLLAVI--VNCIAKRESDVNFEMVYREYNEFC-KTSYS-NSYDKNVLRKCLDHLLDLDLV 1195
            +G ++    ++  ++   +HGESNS++I+G RG+GKT L++  L +L   ++ + NV QV+L+GLL TDD+ ALK I  QL    +EN   +    +F EN  ++L  L  GD++S   + FI++EFDLF  H NQ L+YN+L+  QS   P+ V+G T RLD+LEL+EKRVKSRFSH QI ++    T   Y E+ R  LT+ +   +SK  Q WN S+K                             ++ +SR+S ++  ++  D+ E+ ++   D K  IL+GL  LE  L+  +  +N I + E   NF+MV+ E+ +F  + S+S ++++K V+ K  +HLL L+L+
Sbjct:   38 YGLDSQYKHLLELLRRTAVHGESNSVLIVGPRGAGKTMLLRCALRELLELQEVKKNVLQVHLSGLLQTDDRIALKEITRQLH---LENVVGDKVFGSFAENLVFLLEALKKGDKSSSRPVFFILDEFDLFAHHKNQTLLYNLLDVSQSAQAPVAVVGLTCRLDMLELLEKRVKSRFSHRQIHLLS-SMTFPQYQETFRSELTLPDTFPDSKFSQEWNLSIK-----------------------------LLALSRVSVSNPTVQAADILEANRMSAADSKANILHGLSILELCLIIAMKHLNDIYEGEP-FNFQMVHNEFKKFIQRKSHSIHNFEKPVVIKAFEHLLQLELI 356
[Close]
BLAST of Origin recognition complex subunit 4 vs. Ensembl Sea Lamprey
Match: orc4 (origin recognition complex, subunit 4 [Source:ZFIN;Acc:ZDB-GENE-040426-2224])

HSP 1 Score: 182.956 bits (463), Expect = 6.117e-54
Identity = 120/305 (39.34%), Postives = 184/305 (60.33%), Query Frame = 2 
Query:  194 IKNAYIHGESNSMMIIGKRGSGKTHLIKSLLNDLNNDEKFRDNVYQVNLNGLLHTDDKCALKSIAFQLKCHLIENEEEEFTSDNFNENFEYILSFLTSGDRNSI-CXXXXXXXXXXXXQHTNQILIYNILNCVQSKGTPIFVLGTTTRLDILELMEKRVKSRFSHCQISMIPFGTTIDLYVESMRKLLTIS-NEANSKLIQRWNDSVKRFSNDSNVLKVLERNFMLSNLIGQLKRLLMIPISRLSSTDVELRVTDLQESWKIVNVDYKTEILYGLCELEFTLLAVI--VNCIAKRESDVNFEMVY 1096
            +K     GE NS++++G RGSGK+ L+K +L +L  +   R+N+ QV+LNGLL  DD+ +LK I  QL+   +EN   +    +F EN  ++L+ L SG+R+    +LF++EEFDLF+ H NQ L+YN+ +  +S  TPI V+G T RLD+LEL+EKRVKSRFSH QI + P     D YV +  + LT+  +  +    + WNDSV+  S D  V +VLE  + +S  +  L  LLM+ +S+++     +    LQE+ +++  D  T +L G+  LE  L+  +  +N I   E   NF+MV+
Sbjct:   51 LKRTTTQGEGNSVLVVGSRGSGKSMLLKGVLKELLENNSIRENLMQVHLNGLLQKDDRISLKEITRQLQ---LENTVGDKVFGSFAENLTFLLTALKSGERSRTRPVLFVLEEFDLFVHHKNQALLYNLFDVAKSAQTPIAVVGLTCRLDVLELLEKRVKSRFSHRQIHIFP-CPEFDDYVAAFCQTLTLPLSFPDVAFAKSWNDSVQMLSEDQAVREVLENQYFMSKDVRSLHALLMLALSQVTLRAPRISAAALQEAGRLLTADSVTNLLQGVSVLELCLIIAMKHLNDIYDGEP-FNFQMVF 350
[Close]
BLAST of Origin recognition complex subunit 4 vs. Ensembl Yeast
Match: ORC4 (Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; ORC4 has a paralog, RIF2, that arose from the whole genome duplication [Source:SGD;Acc:S000006366])

HSP 1 Score: 97.8265 bits (242), Expect = 1.867e-22
Identity = 106/347 (30.55%), Postives = 177/347 (51.01%), Query Frame = 2 
Query:  194 IKNAYIHGESNSMMIIGKRGSGKTHLIKSLLNDLNNDEKFRDNVYQVNLNGLLHTDDKCALKSIAFQLKCHL--IENEEEEF--------TSDNFNENFEYILSFLTSG-----------DRNSICXXXXX---XXXXXXXQHTNQILIYNILNCVQSKGTPIFVLGTTTRLDILELMEKRVKSRFSHCQISMIPFGTTIDLYVESMRKLLTISNEANSKLIQRWNDSVKRFSND--SNVLKVLERNFMLSNLIGQLKRLLMIPISRLSSTDVELRVTDLQESWKIVNVDYKTEI-------LYGLCELEFTLLAVIVNC--IAKRESD--VNFEMVYREYNEFCKT 1123
            IK + I  ES+S++++G R S KT+L+   L+ L   + +++    + LNG +H++ + A+  IA QL+  L  I   EE+         +S +  E FE IL  L S            DR SI  + ++   +E D F     Q L+YN+ + V+    P+ + G TT+L+ILE +EKRVKSRFS   I M P    +D  V+++R LLT+ +E  S  + +WN+++++  +D  SN+ + +  NF     +  LK  + IP+   S     L  T ++ S   +++  K ++       L  L +LE   LA++++   +A R  D   NF + Y EY +  K 
Sbjct:   86 IKQSIIQKESHSVILVGPRQSYKTYLLDYELSLLQ--QSYKEQFITIRLNGFIHSE-QTAINGIATQLEQQLQKIHGSEEKIDDTSLETISSGSLTEVFEKILLLLDSTTKTRNEDSGEVDRESITKITVVFIFDEIDTFAGPVRQTLLYNLFDMVEHSRVPVCIFGCTTKLNILEYLEKRVKSRFSQRVIYM-PQIQNLDDMVDAVRNLLTVRSEI-SPWVSQWNETLEKELSDPRSNLNRHIRMNFETFRSLPTLKNSI-IPLVATSKNFGSL-CTAIK-SCSFLDIYNKNQLSNNLTGRLQSLSDLE---LAILISAARVALRAKDGSFNFNLAYAEYEKMIKA 421
[Close]
BLAST of Origin recognition complex subunit 4 vs. Ensembl Nematostella
Match: EDO42930 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RZZ9])

HSP 1 Score: 201.445 bits (511), Expect = 3.376e-60
Identity = 137/339 (40.41%), Postives = 202/339 (59.59%), Query Frame = 2 
Query:  212 HGESNSMMIIGKRGSGKTHLIKSLLNDLNNDEKFRDNVYQVNLNGLLHTDDKCALKSIAFQLKCHLIENEEEEFTSDNFNENFEYILSFLTSGDRNSICXXXXXXXXXXXXQHTNQILIYNILNCVQSKGTPIFVLGTTTRLDILELMEKRVKSRFSHCQISMIPFGTTIDLYVESMRKLLTIS-NEANSKLIQRWNDSVKRFSNDSNVLKVLERNFMLSNLIGQLKRLLMIPISRLSSTDVELRVTDLQESWKIVNVDYKTEILYGLCELEFTLLAVIVNCIAKRESD-VNFEMVYREYNEFCKTS--YSNSYDKNVLRKCLDHLLDLDLVGMKKGKT 1216
            +GESNS++IIG RGSGK+ L+K +L DL+  +  ++N+ QV LNGL+ TDD+ A+  I  QL+   +EN   E    +  EN  ++L  L  G   S  +LFI++EFDLF+ H NQ L+YN+ +  QS  TP+ V+G + RLD++EL+EKRVKSRFSH QI +     + + Y+  +R +LT+  +  N+  IQ WNDSVK    DS     L R F +S  +  L RLL  PI  LS  +  +   D+  S   +N+D K  IL+GL  LE  L+  + + +     +  NFEMVY+EY +F +     + S++K V+ K  +HLL L+LV   +G +
Sbjct:   21 YGESNSVLIIGPRGSGKSLLVKDVLKDLSKSKTAKENMLQVYLNGLVQTDDRLAMLDITRQLQ---LENTVGERVFGSSAENLAFLLDSLKCG-HASQSILFILDEFDLFVHHKNQTLLYNLFDVSQSAQTPVCVVGLSCRLDVVELLEKRVKSRFSHRQIHLFN-SFSFEEYLGIVRSILTLPRSSGNTSFIQCWNDSVKVLLEDSKSRDTLRRQFHVSKDVRSLHRLLTQPICNLSPDNPFITPDDIVASHAELNMDSKGAILHGLSVLEICLIVAMKHLLTTFNGEPFNFEMVYKEYKKFTQRPGHTAQSFEKAVVLKAFEHLLALELVKPVEGSS 354
[Close]
BLAST of Origin recognition complex subunit 4 vs. Ensembl Medaka
Match: orc4 (origin recognition complex subunit 4 [Source:NCBI gene;Acc:101173285])

HSP 1 Score: 203.756 bits (517), Expect = 2.461e-60
Identity = 132/340 (38.82%), Postives = 213/340 (62.65%), Query Frame = 2 
Query:  194 IKNAYIHGESNSMMIIGKRGSGKTHLIKSLLNDLNNDEKFRDNVYQVNLNGLLHTDDKCALKSIAFQLKCHLIENEEEEFTSDNFNENFEYILSFLTSGDR-NSICXXXXXXXXXXXXQHTNQILIYNILNCVQSKGTPIFVLGTTTRLDILELMEKRVKSRFSHCQISMIPFGTTIDLYVESMRKLLTISNE-ANSKLIQRWNDSVKRFSNDSNVLKVLERNFMLSNLIGQLKRLLMIPISRLSSTDVELRVTDLQESWKIVNVDYKTEILYGLCELEFTLLAVI--VNCIAKRESDVNFEMVYREYNEFCKTSYSNSYD--KNVLRKCLDHLLDLDLV 1195
            ++   ++GESNS++I+G RG+GK+ L++S+L +L  +++ ++N+ QV+LNGLL TDD+ ALK I  QL    +EN   E    +F EN  ++L  L  GDR +S  +LF+++EFDLF  H NQ L+YN+ +  QS   P+ V+G T RLD+LEL+EKRVKSRFSH QI ++  G T   Y++ +R  L++S++  +S+  Q WN SVK    D +V  VL+R+F  S     L  LLM+ +SR++     ++ +DL ++ ++   D KT +L+GL  +E  L+  +  +N + + E   N +MV+ E+ +F +   ++ Y+    V+ K  +HL  L+LV
Sbjct:   51 LRRTAVYGESNSVLIVGPRGAGKSSLLRSVLQELLEEKEVQENLLQVHLNGLLQTDDRIALKEITRQLH---LENVVGEKVFGSFAENLAFLLEALKKGDRTSSRPVLFVLDEFDLFAHHKNQTLLYNLFDVSQSTQAPVAVVGLTCRLDVLELLEKRVKSRFSHRQIHLLS-GLTFSQYLDRVRAQLSLSDDFCDSRFAQEWNASVKNLIEDKSVQDVLQRHFDCSKDFRSLHVLLMLCLSRVTLAKPTIKASDLLDASRLCLADCKTNMLHGLSIVELCLIIAMKHLNDVYEGEP-FNLQMVHNEFKKFLQRKSNSMYNFSPPVIVKGFEHLQQLELV 385
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BLAST of Origin recognition complex subunit 4 vs. Planmine SMEST
Match: SMESG000043431.1 (SMESG000043431.1)

HSP 1 Score: 822.772 bits (2124), Expect = 0.000e+0
Identity = 417/420 (99.29%), Postives = 419/420 (99.76%), Query Frame = 2 
Query:   83 MNSNFMSDIVSPLRRKIYSSNHEFFGYENYESRIIPSIKNAYIHGESNSMMIIGKRGSGKTHLIKSLLNDLNNDEKFRDNVYQVNLNGLLHTDDKCALKSIAFQLKCHLIENEEEEFTSDNFNENFEYILSFLTSGDRNSICXXXXXXXXXXXXQHTNQILIYNILNCVQSKGTPIFVLGTTTRLDILELMEKRVKSRFSHCQISMIPFGTTIDLYVESMRKLLTISNEANSKLIQRWNDSVKRFSNDSNVLKVLERNFMLSNLIGQLKRLLMIPISRLSSTDVELRVTDLQESWKIVNVDYKTEILYGLCELEFTLLAVIVNCIAKRESDVNFEMVYREYNEFCKTSYSNSYDKNVLRKCLDHLLDLDLVGMKKGKTGNSNFNPFQCFILHRDLAECVKRKKVSSYLQQFINDKLVSLC 1342
            MNSNFMSDIVSPLRR+IYSSNHEFFGYENYESRIIPSIKNAYIHGESNSMMIIGKRGSGKTHLIKSLLNDLNNDEKFRDNVYQVNLNGLLHTDDKCALKSIAFQLKCHLIENEEEEFTSDNFNENFEYILSFLTSGDRNSICLLFIIEEFDLFLQHTNQILIYNILNCVQSKGTPIFVLGTTTRLDILELMEKRVKSRFSHCQISMIPFGTTIDLYVESM KLLTISNEANSKLIQRWNDSVKRFSNDSNVLKVLERNFMLSNLIGQLKRLLMIPISRLSSTDVELRVTDLQESWKI+NVDYKTEILYGLCELEFTLLAVIVNCIAKRESDVNFEMVYREYNEFCKTSYSNSYDKNVLRKCLDHLLDLDLVGMKKGKTGNSNFNPFQCFILHRDLAECVKRKKVSSYLQQFINDKLVSLC
Sbjct:    1 MNSNFMSDIVSPLRRRIYSSNHEFFGYENYESRIIPSIKNAYIHGESNSMMIIGKRGSGKTHLIKSLLNDLNNDEKFRDNVYQVNLNGLLHTDDKCALKSIAFQLKCHLIENEEEEFTSDNFNENFEYILSFLTSGDRNSICLLFIIEEFDLFLQHTNQILIYNILNCVQSKGTPIFVLGTTTRLDILELMEKRVKSRFSHCQISMIPFGTTIDLYVESMHKLLTISNEANSKLIQRWNDSVKRFSNDSNVLKVLERNFMLSNLIGQLKRLLMIPISRLSSTDVELRVTDLQESWKIINVDYKTEILYGLCELEFTLLAVIVNCIAKRESDVNFEMVYREYNEFCKTSYSNSYDKNVLRKCLDHLLDLDLVGMKKGKTGNSNFNPFQCFILHRDLAECVKRKKVSSYLQQFINDKLVSLC 420
The following BLAST results are available for this feature:
BLAST of Origin recognition complex subunit 4 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ORC42.991e-6639.35origin recognition complex subunit 4 [Source:HGNC ... [more]
ORC42.991e-6639.35origin recognition complex subunit 4 [Source:HGNC ... [more]
ORC42.991e-6639.35origin recognition complex subunit 4 [Source:HGNC ... [more]
ORC43.074e-5337.92origin recognition complex subunit 4 [Source:HGNC ... [more]
ORC44.924e-5238.10origin recognition complex subunit 4 [Source:HGNC ... [more]
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BLAST of Origin recognition complex subunit 4 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Origin recognition complex subunit 4 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
Orc42.505e-4232.64gene:FBgn0023181 transcript:FBtr0072425[more]
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BLAST of Origin recognition complex subunit 4 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
orc41.581e-6038.46origin recognition complex, subunit 4 [Source:ZFIN... [more]
orc41.581e-6038.46origin recognition complex, subunit 4 [Source:ZFIN... [more]
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BLAST of Origin recognition complex subunit 4 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ppil41.056e-6333.16peptidylprolyl isomerase like 4 [Source:Xenbase;Ac... [more]
ppil41.134e-6333.16peptidylprolyl isomerase like 4 [Source:Xenbase;Ac... [more]
ppil49.722e-6035.33peptidylprolyl isomerase like 4 [Source:Xenbase;Ac... [more]
ppil41.231e-5934.93peptidylprolyl isomerase like 4 [Source:Xenbase;Ac... [more]
ppil41.436e-5733.86peptidylprolyl isomerase like 4 [Source:Xenbase;Ac... [more]
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BLAST of Origin recognition complex subunit 4 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Orc41.322e-6235.88origin recognition complex, subunit 4 [Source:MGI ... [more]
Orc41.199e-3942.18origin recognition complex, subunit 4 [Source:MGI ... [more]
Orc42.317e-1540.74origin recognition complex, subunit 4 [Source:MGI ... [more]
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BLAST of Origin recognition complex subunit 4 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|O43929|ORC4_HUMAN1.436e-6539.35Origin recognition complex subunit 4 OS=Homo sapie... [more]
sp|Q5R6Z7|ORC4_PONAB5.122e-6538.60Origin recognition complex subunit 4 OS=Pongo abel... [more]
sp|Q2YDI2|ORC4_BOVIN1.049e-6237.53Origin recognition complex subunit 4 OS=Bos taurus... [more]
sp|Q6P9Z8|ORC4_RAT5.301e-6235.71Origin recognition complex subunit 4 OS=Rattus nor... [more]
sp|O93479|ORC4_XENLA7.616e-6234.66Origin recognition complex subunit 4 OS=Xenopus la... [more]
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BLAST of Origin recognition complex subunit 4 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
R7VC254.841e-6837.75Origin recognition complex subunit 4 OS=Capitella ... [more]
A0A250Y0V53.676e-6540.81Origin recognition complex subunit 4 OS=Castor can... [more]
G1P7552.330e-6439.74Origin recognition complex subunit 4 OS=Myotis luc... [more]
A0A5F8A6516.380e-6439.38Origin recognition complex subunit 4 OS=Macaca mul... [more]
A0A2K6BS718.773e-6439.38Origin recognition complex subunit 4 OS=Macaca nem... [more]
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BLAST of Origin recognition complex subunit 4 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
orc43.526e-5839.09origin recognition complex subunit 4 [Source:NCBI ... [more]
orc49.845e-5336.26origin recognition complex subunit 4 [Source:NCBI ... [more]
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BLAST of Origin recognition complex subunit 4 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
orc46.117e-5439.34origin recognition complex, subunit 4 [Source:ZFIN... [more]
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BLAST of Origin recognition complex subunit 4 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
ORC41.867e-2230.55Subunit of the origin recognition complex (ORC); O... [more]
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BLAST of Origin recognition complex subunit 4 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO429303.376e-6040.41Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Origin recognition complex subunit 4 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
orc42.461e-6038.82origin recognition complex subunit 4 [Source:NCBI ... [more]
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BLAST of Origin recognition complex subunit 4 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000043431.10.000e+099.29SMESG000043431.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30031539 ID=SMED30031539|Name=Origin recognition complex subunit 4|organism=Schmidtea mediterranea sexual|type=transcript|length=1362bp
CACTTGATGTCGGTTAAAACTTTAATTTGCCATTCAAATTTAATTTAATT
TCAAAATTTATTGAATTAGCTTCATTAAAAATATGAATTCAAATTTCATG
TCCGATATTGTAAGTCCCTTGCGCAGAAAAATCTATTCCTCAAATCATGA
ATTTTTTGGATATGAAAATTATGAAAGTAGAATTATTCCTTCAATTAAAA
ATGCTTATATACACGGAGAGAGTAATTCAATGATGATTATTGGTAAAAGA
GGTTCTGGGAAAACTCACTTAATTAAAAGTTTATTAAATGATTTAAATAA
TGATGAAAAATTTCGTGACAATGTCTATCAAGTTAATTTAAATGGACTTT
TACATACTGATGATAAATGTGCTCTTAAATCTATTGCATTTCAACTGAAA
TGTCATTTGATAGAAAATGAAGAAGAGGAATTTACATCTGACAACTTCAA
TGAAAATTTCGAATATATATTATCGTTTTTAACTTCTGGTGATCGTAACA
GCATTTGTCTATTATTTATCATTGAAGAATTCGATTTATTTCTCCAACAT
ACAAATCAAATTCTTATTTACAATATTCTCAACTGTGTACAGTCGAAAGG
GACTCCGATTTTTGTTTTAGGCACAACAACAAGATTGGATATTCTTGAAT
TAATGGAGAAACGAGTAAAATCCAGATTTTCCCACTGCCAAATCTCGATG
ATTCCATTTGGGACAACTATCGATTTGTACGTTGAATCGATGCGCAAATT
GTTGACAATTTCCAATGAGGCAAATTCGAAACTCATTCAACGGTGGAATG
ATTCGGTGAAGAGATTTTCCAATGATTCCAACGTTCTTAAGGTTTTAGAG
CGAAACTTTATGCTGTCGAATTTGATTGGTCAATTGAAACGGCTGTTGAT
GATTCCAATTTCGAGATTGTCGTCGACAGATGTCGAGTTGCGAGTGACAG
ATTTGCAGGAATCATGGAAAATTGTCAATGTTGATTATAAAACCGAAATC
CTTTACGGTCTCTGTGAATTAGAATTTACTCTCCTTGCTGTGATCGTAAA
TTGCATTGCAAAAAGAGAATCGGATGTCAATTTTGAGATGGTTTATAGAG
AATATAATGAGTTTTGCAAGACATCCTATTCTAACTCCTATGATAAGAAT
GTGCTGCGAAAATGTCTCGATCATTTATTGGATCTTGATTTAGTTGGCAT
GAAGAAAGGCAAAACTGGAAATTCGAATTTCAATCCTTTCCAGTGCTTCA
TTCTTCATCGCGACTTGGCGGAATGCGTAAAAAGAAAGAAAGTATCGTCG
TATTTACAACAATTTATCAATGACAAATTAGTGTCTTTATGTTAAAATAT
ATTTAATACAGG
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protein sequence of SMED30031539-orf-1

>SMED30031539-orf-1 ID=SMED30031539-orf-1|Name=SMED30031539-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=421bp
MNSNFMSDIVSPLRRKIYSSNHEFFGYENYESRIIPSIKNAYIHGESNSM
MIIGKRGSGKTHLIKSLLNDLNNDEKFRDNVYQVNLNGLLHTDDKCALKS
IAFQLKCHLIENEEEEFTSDNFNENFEYILSFLTSGDRNSICLLFIIEEF
DLFLQHTNQILIYNILNCVQSKGTPIFVLGTTTRLDILELMEKRVKSRFS
HCQISMIPFGTTIDLYVESMRKLLTISNEANSKLIQRWNDSVKRFSNDSN
VLKVLERNFMLSNLIGQLKRLLMIPISRLSSTDVELRVTDLQESWKIVNV
DYKTEILYGLCELEFTLLAVIVNCIAKRESDVNFEMVYREYNEFCKTSYS
NSYDKNVLRKCLDHLLDLDLVGMKKGKTGNSNFNPFQCFILHRDLAECVK
RKKVSSYLQQFINDKLVSLC*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000014zeta neoblast
PLANA:0000420parapharyngeal region
PLANA:0000429neoblast
PLANA:0002109X1 cell
PLANA:0002111X2 cell
Vocabulary: INTERPRO
TermDefinition
IPR003593AAA+_ATPase
IPR027417P-loop_NTPase
IPR016527ORC4
IPR032705ORC4_C
IPR011991WHTH_DNA-bd_dom
Vocabulary: cellular component
TermDefinition
GO:0000808origin recognition complex
GO:0005634nucleus
GO:0000784nuclear chromosome, telomeric region
GO:0005654nucleoplasm
GO:0005664nuclear origin of replication recognition complex
GO:0005730nucleolus
GO:0005829cytosol
Vocabulary: molecular function
TermDefinition
GO:0003677DNA binding
GO:0000166nucleotide binding
GO:0003688DNA replication origin binding
GO:0005515protein binding
GO:0005524ATP binding
Vocabulary: biological process
TermDefinition
GO:0006260DNA replication
GO:0000082G1/S transition of mitotic cell cycle
GO:0006270DNA replication initiation
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR032705Origin recognition complex subunit 4, C-terminalPFAMPF14629ORC4_Ccoord: 225..398
e-value: 8.4E-28
score: 97.2
IPR016527Origin recognition complex subunit 4PIRSFPIRSF007858ORC4coord: 1..417
e-value: 2.5E-88
score: 294.3
IPR016527Origin recognition complex subunit 4PANTHERPTHR12087ORIGIN RECOGNITION COMPLEX SUBUNIT 4coord: 27..414
IPR003593AAA+ ATPase domainPFAMPF13401AAA_22coord: 47..185
e-value: 2.1E-7
score: 31.3
NoneNo IPR availableGENE3DG3DSA:3.40.50.300coord: 28..208
e-value: 3.9E-31
score: 110.2
NoneNo IPR availableCDDcd00009AAAcoord: 48..201
e-value: 1.49776E-4
score: 39.8219
IPR027417P-loop containing nucleoside triphosphate hydrolaseSUPERFAMILYSSF52540P-loop containing nucleoside triphosphate hydrolasescoord: 32..247