RBR-type E3 ubiquitin transferase

Overview
NameRBR-type E3 ubiquitin transferase
Smed IDSMED30031537
Length (bp)1341
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of RBR-type E3 ubiquitin transferase (SMED30031537) t-SNE clustered cells

Violin plots show distribution of expression levels for RBR-type E3 ubiquitin transferase (SMED30031537) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of RBR-type E3 ubiquitin transferase (SMED30031537) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for RBR-type E3 ubiquitin transferase (SMED30031537) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30031537

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 1

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
parenchymaSMED30031537SMESG000081048.1 dd_Smed_v4_11580_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Human
Match: RNF14 (ring finger protein 14 [Source:HGNC Symbol;Acc:HGNC:10058])

HSP 1 Score: 149.828 bits (377), Expect = 1.258e-39
Identity = 122/439 (27.79%), Postives = 191/439 (43.51%), Query Frame = 2
Query:  107 EELEALVEIYTNLNYKLTEFYESLTIFFSADIKLNEFKELQ-------IQNNQEFFKINFFPPISINLSFDKYSELLD---ISLLCIWLSDDLLETVRIKVISLLKE-SGDGVLWKCFQFLENETLTFL------------------------------FGTHSN-----EFVLDIHRMIDETNGKLLYESLKDYNNRMNESTFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFECMICGQD-----IENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPR--CEMTVLVE-GEEFGICPKCFFVFCIRCKMMYRGSCICN-SVVKMISIFGCLINCTNVYNIKFSNYLEKE--EKVNAELE-------NYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHF 1231
            +EL AL  IY    ++  E  +        D+  N FK          +QN+   + I F PP+ +N               +L   WLS   L  +   + +L +E  G  VL+   QFL+ ETL +L                              FG  +      E ++D   + D  +   L + + D++       FN+ +F CS+C   K G  C+ F +C+HV+C AC  DY++IQI++G +  +C+ C +          ++++++  E F R+D+L+L   L        CPR  C++ V+ E G   GIC  C F FC  C++ Y G   C  +  K++ +    +               K   +K   E+E       N KSCP C    EK+DGCNKMTC+ C  YFC++C   L +  PY+HF
Sbjct:   11 DELLALASIYDGDEFRKAESVQGGETRIYLDLPQN-FKIFVSGNSNECLQNSGFEYTICFLPPLVLNFELPPDYPSSSPPSFTLSGKWLSPTQLSALCKHLDNLWEEHRGSVVLFAWMQFLKEETLAYLNIVSPFELKIGSQKKVQRRTAQASPNTELDFGGAAGSDVDQEEIVDERAVQDVESLSNLIQEILDFDQAQQIKCFNSKLFLCSICFCEKLGSECMYFLECRHVYCKACLKDYFEIQIRDGQV--QCLNCPEPKCPSVATPGQVKELVEAELFARYDRLLLQSSLDLMADVVYCPRPCCQLPVMQEPGCTMGICSSCNFAFCTLCRLTYHGVSPCKVTAEKLMDLRNEYLQADEANKRLLDQRYGKRVIQKALEEMESKEWLEKNSKSCPCCGTPIEKLDGCNKMTCTGCMQYFCWICMGSLSRANPYKHF 446          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Human
Match: RNF14 (ring finger protein 14 [Source:HGNC Symbol;Acc:HGNC:10058])

HSP 1 Score: 149.828 bits (377), Expect = 1.258e-39
Identity = 122/439 (27.79%), Postives = 191/439 (43.51%), Query Frame = 2
Query:  107 EELEALVEIYTNLNYKLTEFYESLTIFFSADIKLNEFKELQ-------IQNNQEFFKINFFPPISINLSFDKYSELLD---ISLLCIWLSDDLLETVRIKVISLLKE-SGDGVLWKCFQFLENETLTFL------------------------------FGTHSN-----EFVLDIHRMIDETNGKLLYESLKDYNNRMNESTFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFECMICGQD-----IENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPR--CEMTVLVE-GEEFGICPKCFFVFCIRCKMMYRGSCICN-SVVKMISIFGCLINCTNVYNIKFSNYLEKE--EKVNAELE-------NYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHF 1231
            +EL AL  IY    ++  E  +        D+  N FK          +QN+   + I F PP+ +N               +L   WLS   L  +   + +L +E  G  VL+   QFL+ ETL +L                              FG  +      E ++D   + D  +   L + + D++       FN+ +F CS+C   K G  C+ F +C+HV+C AC  DY++IQI++G +  +C+ C +          ++++++  E F R+D+L+L   L        CPR  C++ V+ E G   GIC  C F FC  C++ Y G   C  +  K++ +    +               K   +K   E+E       N KSCP C    EK+DGCNKMTC+ C  YFC++C   L +  PY+HF
Sbjct:   11 DELLALASIYDGDEFRKAESVQGGETRIYLDLPQN-FKIFVSGNSNECLQNSGFEYTICFLPPLVLNFELPPDYPSSSPPSFTLSGKWLSPTQLSALCKHLDNLWEEHRGSVVLFAWMQFLKEETLAYLNIVSPFELKIGSQKKVQRRTAQASPNTELDFGGAAGSDVDQEEIVDERAVQDVESLSNLIQEILDFDQAQQIKCFNSKLFLCSICFCEKLGSECMYFLECRHVYCKACLKDYFEIQIRDGQV--QCLNCPEPKCPSVATPGQVKELVEAELFARYDRLLLQSSLDLMADVVYCPRPCCQLPVMQEPGCTMGICSSCNFAFCTLCRLTYHGVSPCKVTAEKLMDLRNEYLQADEANKRLLDQRYGKRVIQKALEEMESKEWLEKNSKSCPCCGTPIEKLDGCNKMTCTGCMQYFCWICMGSLSRANPYKHF 446          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Human
Match: RNF14 (ring finger protein 14 [Source:HGNC Symbol;Acc:HGNC:10058])

HSP 1 Score: 149.828 bits (377), Expect = 1.258e-39
Identity = 122/439 (27.79%), Postives = 191/439 (43.51%), Query Frame = 2
Query:  107 EELEALVEIYTNLNYKLTEFYESLTIFFSADIKLNEFKELQ-------IQNNQEFFKINFFPPISINLSFDKYSELLD---ISLLCIWLSDDLLETVRIKVISLLKE-SGDGVLWKCFQFLENETLTFL------------------------------FGTHSN-----EFVLDIHRMIDETNGKLLYESLKDYNNRMNESTFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFECMICGQD-----IENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPR--CEMTVLVE-GEEFGICPKCFFVFCIRCKMMYRGSCICN-SVVKMISIFGCLINCTNVYNIKFSNYLEKE--EKVNAELE-------NYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHF 1231
            +EL AL  IY    ++  E  +        D+  N FK          +QN+   + I F PP+ +N               +L   WLS   L  +   + +L +E  G  VL+   QFL+ ETL +L                              FG  +      E ++D   + D  +   L + + D++       FN+ +F CS+C   K G  C+ F +C+HV+C AC  DY++IQI++G +  +C+ C +          ++++++  E F R+D+L+L   L        CPR  C++ V+ E G   GIC  C F FC  C++ Y G   C  +  K++ +    +               K   +K   E+E       N KSCP C    EK+DGCNKMTC+ C  YFC++C   L +  PY+HF
Sbjct:   11 DELLALASIYDGDEFRKAESVQGGETRIYLDLPQN-FKIFVSGNSNECLQNSGFEYTICFLPPLVLNFELPPDYPSSSPPSFTLSGKWLSPTQLSALCKHLDNLWEEHRGSVVLFAWMQFLKEETLAYLNIVSPFELKIGSQKKVQRRTAQASPNTELDFGGAAGSDVDQEEIVDERAVQDVESLSNLIQEILDFDQAQQIKCFNSKLFLCSICFCEKLGSECMYFLECRHVYCKACLKDYFEIQIRDGQV--QCLNCPEPKCPSVATPGQVKELVEAELFARYDRLLLQSSLDLMADVVYCPRPCCQLPVMQEPGCTMGICSSCNFAFCTLCRLTYHGVSPCKVTAEKLMDLRNEYLQADEANKRLLDQRYGKRVIQKALEEMESKEWLEKNSKSCPCCGTPIEKLDGCNKMTCTGCMQYFCWICMGSLSRANPYKHF 446          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Human
Match: RNF14 (ring finger protein 14 [Source:HGNC Symbol;Acc:HGNC:10058])

HSP 1 Score: 149.828 bits (377), Expect = 1.258e-39
Identity = 122/439 (27.79%), Postives = 191/439 (43.51%), Query Frame = 2
Query:  107 EELEALVEIYTNLNYKLTEFYESLTIFFSADIKLNEFKELQ-------IQNNQEFFKINFFPPISINLSFDKYSELLD---ISLLCIWLSDDLLETVRIKVISLLKE-SGDGVLWKCFQFLENETLTFL------------------------------FGTHSN-----EFVLDIHRMIDETNGKLLYESLKDYNNRMNESTFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFECMICGQD-----IENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPR--CEMTVLVE-GEEFGICPKCFFVFCIRCKMMYRGSCICN-SVVKMISIFGCLINCTNVYNIKFSNYLEKE--EKVNAELE-------NYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHF 1231
            +EL AL  IY    ++  E  +        D+  N FK          +QN+   + I F PP+ +N               +L   WLS   L  +   + +L +E  G  VL+   QFL+ ETL +L                              FG  +      E ++D   + D  +   L + + D++       FN+ +F CS+C   K G  C+ F +C+HV+C AC  DY++IQI++G +  +C+ C +          ++++++  E F R+D+L+L   L        CPR  C++ V+ E G   GIC  C F FC  C++ Y G   C  +  K++ +    +               K   +K   E+E       N KSCP C    EK+DGCNKMTC+ C  YFC++C   L +  PY+HF
Sbjct:   11 DELLALASIYDGDEFRKAESVQGGETRIYLDLPQN-FKIFVSGNSNECLQNSGFEYTICFLPPLVLNFELPPDYPSSSPPSFTLSGKWLSPTQLSALCKHLDNLWEEHRGSVVLFAWMQFLKEETLAYLNIVSPFELKIGSQKKVQRRTAQASPNTELDFGGAAGSDVDQEEIVDERAVQDVESLSNLIQEILDFDQAQQIKCFNSKLFLCSICFCEKLGSECMYFLECRHVYCKACLKDYFEIQIRDGQV--QCLNCPEPKCPSVATPGQVKELVEAELFARYDRLLLQSSLDLMADVVYCPRPCCQLPVMQEPGCTMGICSSCNFAFCTLCRLTYHGVSPCKVTAEKLMDLRNEYLQADEANKRLLDQRYGKRVIQKALEEMESKEWLEKNSKSCPCCGTPIEKLDGCNKMTCTGCMQYFCWICMGSLSRANPYKHF 446          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Human
Match: RNF14 (ring finger protein 14 [Source:HGNC Symbol;Acc:HGNC:10058])

HSP 1 Score: 139.813 bits (351), Expect = 6.066e-37
Identity = 92/299 (30.77%), Postives = 144/299 (48.16%), Query Frame = 2
Query:  398 SGDGVLWKCFQFLENETLTFLFGTHSN---EFVLDIHRMIDETNGKLLYESLKDYNNRMNESTFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFECMICGQD-----IENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPR--CEMTVLVE-GEEFGICPKCFFVFCIRCKMMYRGSCICN-SVVKMISIFGCLINCTNVYNIKFSNYLEKE--EKVNAELE-------NYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHF 1231
            S   V  +  Q   N  L F     S+   E ++D   + D  +   L + + D++       FN+ +F CS+C   K G  C+ F +C+HV+C AC  DY++IQI++G +  +C+ C +          ++++++  E F R+D+L+L   L        CPR  C++ V+ E G   GIC  C F FC  C++ Y G   C  +  K++ +    +               K   +K   E+E       N KSCP C    EK+DGCNKMTC+ C  YFC++C   L +  PY+HF
Sbjct:   24 SQKKVQRRTAQASPNTELDFGGAAGSDVDQEEIVDERAVQDVESLSNLIQEILDFDQAQQIKCFNSKLFLCSICFCEKLGSECMYFLECRHVYCKACLKDYFEIQIRDGQV--QCLNCPEPKCPSVATPGQVKELVEAELFARYDRLLLQSSLDLMADVVYCPRPCCQLPVMQEPGCTMGICSSCNFAFCTLCRLTYHGVSPCKVTAEKLMDLRNEYLQADEANKRLLDQRYGKRVIQKALEEMESKEWLEKNSKSCPCCGTPIEKLDGCNKMTCTGCMQYFCWICMGSLSRANPYKHF 320          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Celegans
Match: F56D2.5 (RBR-type E3 ubiquitin transferase [Source:UniProtKB/TrEMBL;Acc:Q20871])

HSP 1 Score: 100.523 bits (249), Expect = 7.934e-23
Identity = 88/364 (24.18%), Postives = 158/364 (43.41%), Query Frame = 2
Query:  236 NNQEFFKINFFPPISINLSF-DKYSELLD--ISLLCIWLSDDLLETVRIKVISLLKESGD-GVLWKCFQFLENETLTFLFGTHSNEFVLDIHRMIDETNGKLLYESLK----DYNNRMNESTFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNG--NLKFECMI--CGQDIENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCP--RCEMTVLVEGEEFGI--CPKCFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVYNIK--FSNYLEKEEKVNAEL--------ENYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHFGLAPNC 1249
             +Q    ++  PPI +     + Y  +    + L   W++ + + +   ++  + +E+    VL+ C+Q     T+  L   ++ + +++++            ESLK           E  F N+++DC VC  ++ G +C++F  C HVFC +C  +YY I I  G  +    C+   C  + +   +++ + +E F +++  +L + ++E      CP   C+M   +   +  +  C  C + FC  CK  + G   C    +         N  +    +  +  Y EK  K   E         EN K CP C    EK +GCNKM C+ C   FC+LC K L+   PY H+    +C
Sbjct:   61 GDQFHLPLDILPPIRLKFHLPNDYPTVSSPKLELESYWMNQEQMTSCETELAKICEENQMMEVLFMCYQ-----TIIDLMAQNTPK-IINLNEACALNRQGETIESLKMKILQKEEEAVEEQFVNTLYDCQVCFESQMGQHCIKFQPCSHVFCKSCTFNYY-ISIAKGFVSKPMSCLAEGCENEAQQGMVQEALGEELFAKYEAHMLEKAIREMDDSMECPNENCQMVAYLTDSQRNLVECSYCNYSFCNLCKGTFHGVSRCKFRKEDEERIMKEWNEADEAGKEEMYKRYGEKNMKALEERFLNRGWLEENSKQCPKCLVYIEKDEGCNKMHCTKCNASFCWLCSKTLNNVDPYSHYSEKGSC 417          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Celegans
Match: F56D2.2 (RBR-type E3 ubiquitin transferase [Source:UniProtKB/TrEMBL;Acc:Q20874])

HSP 1 Score: 86.6557 bits (213), Expect = 3.490e-18
Identity = 88/351 (25.07%), Postives = 142/351 (40.46%), Query Frame = 2
Query:  257 INFFPPISINLSF-DKYSELLD--ISLLCIWLSDDLLETVRIKVISLLKESGD-GVLWKCFQFLENETLTFLFGTHSNEFVLDIHRMIDETNGKLLYESLK----DYNNRMNESTFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFECMICGQDIENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPRCEMTVLVEGEEFGICPKCFFVFCIRCKMMYRG--SCICNSVVKMISIFGCLINCTNVYNIKFSNYLEKEEKVNAELE----------NYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHFGLAPNC 1249
            ++  PPI +     + Y  +    + L   W++ + + +   ++  + +E+    VL+ C+Q + +          S+  +++++      N     ESLK           E  F N++FDC VC  ++ G +C++F  C HVFC  C  DYY   I  G +  + M C  +    E ++   KE     D L   Q                  L E      C  C F FC  CK  + G   C      K + +     +       +       E++V   +E          N K CP C  + EK +GC+KM C+ C  YFC+LC + LDK  PY+HF    +C
Sbjct:   70 LDILPPIRLKFHLPNDYPSVSSPKLELESYWMNQEQMTSCETELARICEENQMMEVLFMCYQTIIDSI------DQSHLKIINLNEACALKNNGETIESLKKKILGKGEEAAEEHFVNTLFDCEVCYDSQMGQHCIKFQPCSHVFCKQCTFDYYRT-ISKGVVS-KAMQCLAEGCKSEAQQNTVKEAL--GDDLYAKQ----------------RFLAE------CSYCNFSFCNLCKQTFHGIERCKWKKGDKEL-LVKRWKDGDEAEKAEMCRQFGGEKRVEELVERFLNEEWLDSNSKPCPKCSVSIEKNEGCHKMHCTKCDTYFCWLCSETLDKEDPYKHFQGDGSC 387          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Celegans
Match: C17H11.6 (RBR-type E3 ubiquitin transferase [Source:UniProtKB/TrEMBL;Acc:A0A0K3AYH3])

HSP 1 Score: 60.8474 bits (146), Expect = 1.168e-9
Identity = 54/249 (21.69%), Postives = 97/249 (38.96%), Query Frame = 2
Query:  509 DETNGKLLYESLKDYNNRMNE--STFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFECMICGQDIENLEIRKVMT--KEEFERWDKLILNQCLKEEKSFYNCPRCEMTVLVEGEEFGICPK-------CFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVYNIKFSNYLEKEEKVNAELENYKSCPGCKQAFEKID--GCNKMTCSYCRIYFCYLC-RKILDKH 1213
            ++++ K L +SL D     +E        + +C +C     G    +   C+H  C AC   Y ++ I    ++  C  C   +   +I+ ++       E+++   L + L  E     CP  +   +    +   CP+       C  +FC  CK  +  +  C+   +        +    +    F    +   K      + K+CP CK    K+D   CN M C+ C   FC+LC ++I D H
Sbjct:   23 EQSDEKQLSQSLPDTPKTPSEVGKKGKGKMKECPLCAAKMPGSAFPKLKGCQHRSCRACLRQYVELSITENRVEVPCPECSSYLHPNDIKMLIGDIPTLIEKYEAFSLRRYLMTEADARWCPAPDCGFVFIATKCAACPQLKCQRPDCGTLFCYHCKREWHSNQTCDEARRPEKRKSRGLAFEEIMRTGFHQSADSTLKPG----DVKACPRCKTYIVKMDDGSCNHMVCTMCNAEFCWLCLKEISDLH 267          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Celegans
Match: C17H11.6 (RBR-type E3 ubiquitin transferase [Source:UniProtKB/TrEMBL;Acc:A0A0K3AYH3])

HSP 1 Score: 60.8474 bits (146), Expect = 1.168e-9
Identity = 54/249 (21.69%), Postives = 97/249 (38.96%), Query Frame = 2
Query:  509 DETNGKLLYESLKDYNNRMNE--STFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFECMICGQDIENLEIRKVMT--KEEFERWDKLILNQCLKEEKSFYNCPRCEMTVLVEGEEFGICPK-------CFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVYNIKFSNYLEKEEKVNAELENYKSCPGCKQAFEKID--GCNKMTCSYCRIYFCYLC-RKILDKH 1213
            ++++ K L +SL D     +E        + +C +C     G    +   C+H  C AC   Y ++ I    ++  C  C   +   +I+ ++       E+++   L + L  E     CP  +   +    +   CP+       C  +FC  CK  +  +  C+   +        +    +    F    +   K      + K+CP CK    K+D   CN M C+ C   FC+LC ++I D H
Sbjct:   23 EQSDEKQLSQSLPDTPKTPSEVGKKGKGKMKECPLCAAKMPGSAFPKLKGCQHRSCRACLRQYVELSITENRVEVPCPECSSYLHPNDIKMLIGDIPTLIEKYEAFSLRRYLMTEADARWCPAPDCGFVFIATKCAACPQLKCQRPDCGTLFCYHCKREWHSNQTCDEARRPEKRKSRGLAFEEIMRTGFHQSADSTLKPG----DVKACPRCKTYIVKMDDGSCNHMVCTMCNAEFCWLCLKEISDLH 267          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Celegans
Match: C17H11.6 (RBR-type E3 ubiquitin transferase [Source:UniProtKB/TrEMBL;Acc:A0A0K3AYH3])

HSP 1 Score: 60.4622 bits (145), Expect = 1.773e-9
Identity = 58/261 (22.22%), Postives = 100/261 (38.31%), Query Frame = 2
Query:  479 EFVLDIHRMIDE--TNGKLLYESLKDYNNRMNE--STFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFECMICGQDIENLEIRKVMT--KEEFERWDKLILNQCLKEEKSFYNCPRCEMTVLVEGEEFGICPK-------CFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVYNIKFSNYLEKEEKVNAELENYKSCPGCKQAFEKID--GCNKMTCSYCRIYFCYLC-RKILDKH 1213
            E +L      DE  ++ K L +SL D     +E        + +C +C     G    +   C+H  C AC   Y ++ I    ++  C  C   +   +I+ ++       E+++   L + L  E     CP  +   +    +   CP+       C  +FC  CK  +  +  C+   +        +    +    F    +   K      + K+CP CK    K+D   CN M C+ C   FC+LC ++I D H
Sbjct:   41 EMLLSSRNQDDEEQSDEKQLSQSLPDTPKTPSEVGKKGKGKMKECPLCAAKMPGSAFPKLKGCQHRSCRACLRQYVELSITENRVEVPCPECSSYLHPNDIKMLIGDIPTLIEKYEAFSLRRYLMTEADARWCPAPDCGFVFIATKCAACPQLKCQRPDCGTLFCYHCKREWHSNQTCDEARRPEKRKSRGLAFEEIMRTGFHQSADSTLKPG----DVKACPRCKTYIVKMDDGSCNHMVCTMCNAEFCWLCLKEISDLH 297          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Fly
Match: ari-2 (gene:FBgn0025186 transcript:FBtr0071774)

HSP 1 Score: 62.7734 bits (151), Expect = 2.539e-10
Identity = 54/206 (26.21%), Postives = 82/206 (39.81%), Query Frame = 2
Query:  599 CSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNG-NLKFECM--ICGQDI-ENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPRCEMTVLVEGEEF----GICPKCFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVYNIKFSNYLEKEEKVNAELENYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLC 1192
            C VC  ++ G        C H FC  C   Y++ QI  G + +  CM  +C   + E+L +  V      +++ +      +K       CP     ++V+  E      IC  C   FC RC M Y     C  + K       L  C +  + + +NY+           + K CP C    EK  GCN M C  C+  FC++C
Sbjct:  153 CPVCASSQLGDKFYSLA-CGHSFCKDCWTIYFETQIFQGISTQIGCMAQMCNVRVPEDLVLTLVTRPVMRDKYQQFAFKDYVKSHPELRFCPGPNCQIIVQSSEISAKRAICKACHTGFCFRCGMDYHAPTDCQVIKKW------LTKCAD--DSETANYISA---------HTKDCPKCHICIEKNGGCNHMQCFNCKHDFCWMC 340          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Fly
Match: CG33144 (gene:FBgn0053144 transcript:FBtr0302517)

HSP 1 Score: 58.5362 bits (140), Expect = 9.827e-9
Identity = 59/270 (21.85%), Postives = 90/270 (33.33%), Query Frame = 2
Query:  593 FDCSVCTIAKRGI-NCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFEC--MICGQD--IENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPR--CEMTVLV-----EGEEFGIC-----------------------------------------PKCFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVYNIKFSNYLEKEEKVNAELENYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHFGLAP 1243
            F C +C I    +   +   +C   FC+ C   Y + +I  G  +  C    C     I   EI  + T    ++  +  LN+ ++ +K+   CPR  CE    V      G+   IC                                         P C   FC  CK  Y  +  C+   + +     + +  +   I F N L             K CP C    EK +GC +M C  C+  FC+ C   LD     +H+   P
Sbjct:  777 FTCKLCLIDVEDVGEAMALQQCGCQFCIECMRAYVEFEISEGAYEISCPDATCPAQGAISLPEIANLTTTNLLKKHHRYRLNREIELDKTRTWCPRAGCETICTVGAAAQPGQSSVICQMDESPSTSQSYSPQQEVAGNGSTGAAAGNGAPVLSVSVHCPSCKDEFCGLCKKAYHPNISCDEFGRRL-----IADGQDDIGIPFDNEL------------IKCCPMCAVPIEKDEGCAQMMCKRCKHVFCWYCLASLDDDFLLRHYDKGP 1029          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Fly
Match: CG33144 (gene:FBgn0053144 transcript:FBtr0088254)

HSP 1 Score: 58.5362 bits (140), Expect = 9.827e-9
Identity = 59/270 (21.85%), Postives = 90/270 (33.33%), Query Frame = 2
Query:  593 FDCSVCTIAKRGI-NCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFEC--MICGQD--IENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPR--CEMTVLV-----EGEEFGIC-----------------------------------------PKCFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVYNIKFSNYLEKEEKVNAELENYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHFGLAP 1243
            F C +C I    +   +   +C   FC+ C   Y + +I  G  +  C    C     I   EI  + T    ++  +  LN+ ++ +K+   CPR  CE    V      G+   IC                                         P C   FC  CK  Y  +  C+   + +     + +  +   I F N L             K CP C    EK +GC +M C  C+  FC+ C   LD     +H+   P
Sbjct:  777 FTCKLCLIDVEDVGEAMALQQCGCQFCIECMRAYVEFEISEGAYEISCPDATCPAQGAISLPEIANLTTTNLLKKHHRYRLNREIELDKTRTWCPRAGCETICTVGAAAQPGQSSVICQMDESPSTSQSYSPQQEVAGNGSTGAAAGNGAPVLSVSVHCPSCKDEFCGLCKKAYHPNISCDEFGRRL-----IADGQDDIGIPFDNEL------------IKCCPMCAVPIEKDEGCAQMMCKRCKHVFCWYCLASLDDDFLLRHYDKGP 1029          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Fly
Match: LUBEL (gene:FBgn0031857 transcript:FBtr0331221)

HSP 1 Score: 55.8398 bits (133), Expect = 7.798e-8
Identity = 51/227 (22.47%), Postives = 88/227 (38.77%), Query Frame = 2
Query:  596 DCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLK-FECMICG---------QDIENLE--------IRKVMTKEEFERWDKLILNQCLKEEKSFYNCPRCEMTVLVEGEEFG-ICPKCFFVFCIRCKM----MYRGSCICNSVVKMISIFGCLINCTNVYNIKFSNYLE-KEEKVNAEL-ENYKSCPGCKQAFE-KIDGCNKMTCSYCRIYFCYLCRK 1198
            +C +C  +      V   KC H  C  CA  Y+ +QI + ++    C  C           + E+LE        ++ ++  +  E + + + ++ L ++ +F  C +C        ++   ICP C  V C +C+      + GS                 +C      K  N  E + + V   L +N   CP CK  +     GC   TC+ C+  FCY C +
Sbjct: 2419 ECELCMNSYPMNQMVSMLKCLHKCCKQCAKSYFTVQITDRSINDCSCPFCKLPELSNEAQHEDEHLEYFSNLDIFLKSILDNDVHELFQRKLRDRSLLQDPNFKWCIQCSSGFFARPKQKRLICPDCGSVTCAQCRKPWERQHEGS-----------------SCEAYLEWKRENDPELQAQGVQEHLAQNGIDCPKCKFRYSLARGGCMHFTCTQCKFEFCYGCAR 2628          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Fly
Match: LUBEL (gene:FBgn0031857 transcript:FBtr0331220)

HSP 1 Score: 55.8398 bits (133), Expect = 7.807e-8
Identity = 51/227 (22.47%), Postives = 88/227 (38.77%), Query Frame = 2
Query:  596 DCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLK-FECMICG---------QDIENLE--------IRKVMTKEEFERWDKLILNQCLKEEKSFYNCPRCEMTVLVEGEEFG-ICPKCFFVFCIRCKM----MYRGSCICNSVVKMISIFGCLINCTNVYNIKFSNYLE-KEEKVNAEL-ENYKSCPGCKQAFE-KIDGCNKMTCSYCRIYFCYLCRK 1198
            +C +C  +      V   KC H  C  CA  Y+ +QI + ++    C  C           + E+LE        ++ ++  +  E + + + ++ L ++ +F  C +C        ++   ICP C  V C +C+      + GS                 +C      K  N  E + + V   L +N   CP CK  +     GC   TC+ C+  FCY C +
Sbjct: 2460 ECELCMNSYPMNQMVSMLKCLHKCCKQCAKSYFTVQITDRSINDCSCPFCKLPELSNEAQHEDEHLEYFSNLDIFLKSILDNDVHELFQRKLRDRSLLQDPNFKWCIQCSSGFFARPKQKRLICPDCGSVTCAQCRKPWERQHEGS-----------------SCEAYLEWKRENDPELQAQGVQEHLAQNGIDCPKCKFRYSLARGGCMHFTCTQCKFEFCYGCAR 2669          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Zebrafish
Match: CABZ01061592.1 (E3 ubiquitin-protein ligase RNF14-like [Source:NCBI gene;Acc:558876])

HSP 1 Score: 152.91 bits (385), Expect = 3.257e-41
Identity = 125/424 (29.48%), Postives = 189/424 (44.58%), Query Frame = 2
Query:  107 EELEALVEIYTNLNYKLTEFYESLTIFFSADIKLNEFKELQIQNNQEFFKINFFPPI--SINLSFDKYSELLDI-SLLCIWLSDDLLETVRIKVISLLKES-GDGVLWKCFQFLENETLTFLFGTHSNEF----------------------VLDIHRMIDETNGKLLYESLKDYNNRMNESTFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFECMI---CGQDIENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPR--CEMTVLVEGEE-FGICPKCFFVFCIRCKMMYRGSCICNSV-VKMISIFGCLINCTNVYNIKFSNYLEKEEKVNAE--------LENYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHF-GLAPNCY 1252
            +EL AL  IY    +  TE  +   I    ++   +F+ L     +    +++ PP+  S  L  D  S    + +L  IWLS   + T+  ++  L +E+ G  VL+   QFL+ ETL FL      E                        LD   +        +   L D+N    +  F  ++F C +C     G  CV F +C+HV+C  C  +Y+ I IKNG ++F       C       +++ ++++E+F R+D+L+L   L        CPR  C M V++E +   GICP C FVFC  CK  Y G  IC  + ++M+               +  +Y ++ E++  E         +N K CP C+   EK DGCNKMTC  C  YFC+LC  +L    PY HF  L   CY
Sbjct:   10 DELLALASIYDEEEFHRTESSQKGEIHLCLELP-PDFRLLIKGQTRVEVDVSYLPPLVLSFELPTDYPSSSAPVFTLSSIWLSRVQIATLCKRLDELWEENRGSVVLFTWIQFLKEETLQFLNIQSPLEIQTNGVQPQCESAESQAAAAAVEELDQRAVQVADPHSDILTQLLDFNEAQKKKVFEATVFSCKICFSENLGSKCVLFKECQHVYCKTCVEEYFKILIKNGEVQFLSCPEPECTSLATPAQVKLLVSEEDFARYDRLLLQWSLNLMTDVVYCPRVTCCMAVMLESDRTVGICPSCQFVFCTTCKRTYHGLSICKEIQLRMLKEAREKEQELLEEKERV-DYEKRLEEIETEETLSEDWVTKNCKQCPICRTNIEKSDGCNKMTCFSCHAYFCWLCLAVLGGKDPYLHFRDLESPCY 431          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Zebrafish
Match: rnf14 (ring finger protein 14 [Source:ZFIN;Acc:ZDB-GENE-040625-65])

HSP 1 Score: 149.058 bits (375), Expect = 1.189e-39
Identity = 123/427 (28.81%), Postives = 183/427 (42.86%), Query Frame = 2
Query:  107 EELEALVEIYTNLNYKLTEFYESLTIFFSADIKLNEFKELQIQNNQEFFKINFFPPISINLSFDKYSELLDISLLCIWLSDDLLETVRI-----KVISLLKE-SGDGVLWKCFQFLENETLTFL---------------------------FGTHSNEFVLDIHRMIDETNGKL-LYESLKDYNNRMNESTFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFECM-----ICGQDIENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPR--CEMTVLVEGEE-FGICPKCFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVYNIKF----------SNYLEKEEKVNAELENYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHF 1231
            +EL AL  IY    +   E  +   I    ++  N FK L          I+F PP+   LSFD   +    S     +S   L  V+I     K+  L +E  G+ VL+   QFL+ ETL FL                            G  S    LD  R + E + +  +   L D++    +  F+   F C +C   K G +C+ F +C+HV+C AC  +Y+ IQIK+G  K +C+      C       +++ ++ ++EF R+D+L+L   L        CPR  C M V+VE +   GICP C + FC  C+  Y G   C +    +         ++    KF             +E+    +    N K CP C    +K  GCNKMTCS C+ YFC++C   L +  PY HF
Sbjct:   10 DELLALASIYDEEEFHRAESGKEGEIHLCLELPPN-FKLLVKGQKSAEHNISFLPPLV--LSFDLPDDYPSTSAPIFTISSKWLTRVQITALCRKLDELWEENQGNVVLFTWIQFLKEETLDFLGIQSPLEIQRSGSQPQCEPAQKHAADASGEKSKVQDLD-PRAVQEVDAQTDILTQLLDFDEAQKQRVFDGKAFCCGICYSEKLGCDCLLFKECEHVYCKACIKEYFQIQIKDG--KVQCLNCPEPKCASTATPTQVKLLVGEDEFARYDRLLLQSSLDLMADVVYCPRMSCCMAVMVEPDSTMGICPSCRYAFCTLCRRSYHGLSHCIATADELRSLRDEYLSSSEEGKKFLEKRFGKRVIQRAVEESFSTDWLKTNCKQCPCCGTNIQKAHGCNKMTCSSCQKYFCWICLGALSRVNPYSHF 430          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Zebrafish
Match: rnf14 (ring finger protein 14 [Source:ZFIN;Acc:ZDB-GENE-040625-65])

HSP 1 Score: 149.058 bits (375), Expect = 1.189e-39
Identity = 123/427 (28.81%), Postives = 183/427 (42.86%), Query Frame = 2
Query:  107 EELEALVEIYTNLNYKLTEFYESLTIFFSADIKLNEFKELQIQNNQEFFKINFFPPISINLSFDKYSELLDISLLCIWLSDDLLETVRI-----KVISLLKE-SGDGVLWKCFQFLENETLTFL---------------------------FGTHSNEFVLDIHRMIDETNGKL-LYESLKDYNNRMNESTFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFECM-----ICGQDIENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPR--CEMTVLVEGEE-FGICPKCFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVYNIKF----------SNYLEKEEKVNAELENYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHF 1231
            +EL AL  IY    +   E  +   I    ++  N FK L          I+F PP+   LSFD   +    S     +S   L  V+I     K+  L +E  G+ VL+   QFL+ ETL FL                            G  S    LD  R + E + +  +   L D++    +  F+   F C +C   K G +C+ F +C+HV+C AC  +Y+ IQIK+G  K +C+      C       +++ ++ ++EF R+D+L+L   L        CPR  C M V+VE +   GICP C + FC  C+  Y G   C +    +         ++    KF             +E+    +    N K CP C    +K  GCNKMTCS C+ YFC++C   L +  PY HF
Sbjct:   10 DELLALASIYDEEEFHRAESGKEGEIHLCLELPPN-FKLLVKGQKSAEHNISFLPPLV--LSFDLPDDYPSTSAPIFTISSKWLTRVQITALCRKLDELWEENQGNVVLFTWIQFLKEETLDFLGIQSPLEIQRSGSQPQCEPAQKHAADASGEKSKVQDLD-PRAVQEVDAQTDILTQLLDFDEAQKQRVFDGKAFCCGICYSEKLGCDCLLFKECEHVYCKACIKEYFQIQIKDG--KVQCLNCPEPKCASTATPTQVKLLVGEDEFARYDRLLLQSSLDLMADVVYCPRMSCCMAVMVEPDSTMGICPSCRYAFCTLCRRSYHGLSHCIATADELRSLRDEYLSSSEEGKKFLEKRFGKRVIQRAVEESFSTDWLKTNCKQCPCCGTNIQKAHGCNKMTCSSCQKYFCWICLGALSRVNPYSHF 430          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Zebrafish
Match: zmp:0000000524 (zmp:0000000524 [Source:ZFIN;Acc:ZDB-GENE-130530-527])

HSP 1 Score: 145.976 bits (367), Expect = 4.177e-39
Identity = 108/358 (30.17%), Postives = 172/358 (48.04%), Query Frame = 2
Query:  257 INFFPP--ISINLSFDKYSELLDI-SLLCIWLSDDLLETVRIKVISLLKES-GDGVLWKCFQFLENETLTFLF----------GTH----------SNEFVLDIHR---MIDETNGKLLYESLKDYNNRMNESTFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKF-EC--MICGQDIENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPR--CEMTVLVEGEE-FGICPKCFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVYNIKFSNYLEKEEKVNAELENYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHF 1231
            ++F P   +S  L  D  S    + +L  IWLS   +  +  ++  L +E+ G  VL+   QFL+ ETL FL           G            +N  V ++ +    + + +  +L + L D+N    +  F  ++F C +C     G + V F +C+HV+C  C  DY++IQIK+G ++F  C    C       +++ ++++E F R+D+L+L   L        CPR  C M V++E +   GICP C FVFC  C  +Y    +CN + +               N +  N   KE++V  + +N K CP C    +K  GCNKM CS+C+ YFC++C   L  + PY HF
Sbjct:   23 VSFLPSTILSFELPTDYPSSSAPVFTLSSIWLSRVQITALCKRLDELWEENRGSVVLFTWIQFLKEETLQFLNIQSPLEIQTNGVQPQCESAECQAANAAVEELDQRAVQVADPHSDILTQ-LLDFNEAQKKKVFEATVFSCGICFTENLGSSFVLFNECQHVYCKTCVKDYFEIQIKDGKVQFLSCPEAECTSLATPAQVKLLVSQEVFARYDRLLLQWSLNLMTDVVYCPRKSCGMAVMLEPDRTMGICPSCKFVFCTLCNRVYHALALCNEIQR--------------ENERRENQ-RKEDEVWVK-QNSKQCPTCGVKIQKDMGCNKMACSFCQQYFCWICVSPLQTNDPYSHF 363          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Zebrafish
Match: zmp:0000000524 (zmp:0000000524 [Source:ZFIN;Acc:ZDB-GENE-130530-527])

HSP 1 Score: 144.436 bits (363), Expect = 1.567e-38
Identity = 106/357 (29.69%), Postives = 167/357 (46.78%), Query Frame = 2
Query:  257 INFFPP--ISINLSFDKYSELLDI-SLLCIWLSDDLLETVRIKVISLLKES-GDGVLWKCFQFLENETLTFLFGTHSNEF----------------------VLDIHRMIDETNGKLLYESLKDYNNRMNESTFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKF-EC--MICGQDIENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPR--CEMTVLVEGEE-FGICPKCFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVYNIKFSNYLEKEEKVNAELENYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHF 1231
            ++F P   +S  L  D  S    + +L  IWLS   +  +  ++  L +E+ G  VL+   QFL+ ETL FL      E                        LD   +        +   L D+N    +  F  ++F+C +C     G + V F +C+HV+C  C  DY++IQIK+G ++F  C    C       +++ +++++ F R+D+L+L   L        CPR  C M V++E +   GICP C FVFC  C  +Y    +C  + +            N  + K +  + KE++V  +  N K CP C    +K  GCNKMTCS C  YFC++C  +L+++ PY HF
Sbjct:   23 VSFLPSTILSFELPTDYPSSSAPVFTLSSIWLSRVQITALCKRLDELWEENRGSVVLFTWIQFLKEETLQFLNIQSPLEIQTNGVQLQCESAECQAAAAAVEELDQRAVQVADPHSDILTQLLDFNEAQKKKVFEATVFNCGICFTENLGSSFVLFNECQHVYCKTCVRDYFEIQIKDGKVQFLSCPEAECTSLATPAQVKLLVSQDVFARYDRLLLQWSLNLMTDIVYCPRKSCGMAVMLEPDRTMGICPSCKFVFCTLCNRVYHALALCKEIQE-----------ENERHEKLA-IIRKEDEVWVK-HNSKQCPTCAANIQKEMGCNKMTCSSCLEYFCWICFSVLNRNDPYSHF 366          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Xenopus
Match: ENSXETT00000012882.1 (ring finger protein 14 gene 4 [Source:NCBI gene;Acc:100485068])

HSP 1 Score: 160.614 bits (405), Expect = 1.263e-43
Identity = 119/432 (27.55%), Postives = 192/432 (44.44%), Query Frame = 2
Query:  107 EELEALVEIYTNLNYKLTEFYES--------LTIFFSADIKLNEFKELQIQNNQEFFKINFFPPISINLSFDKYSELLD---ISLLCIWLSDDLLETVRIKVISLLKE-SGDGVLWKCFQFLENETLTFL------------FGTH-----------------SNEFVLDIHRMIDETNGKLLYESLKDYNNRMNESTFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLK-FECM--ICGQDIENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPR--CEMTVLVE-GEEFGICPKCFFVFCIRCKMMYRGSCICN-SVVKMISIFGCLINCTNV--------YNIKF-SNYLEKEEKVNAELENYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHF 1231
            +EL AL  IY+   +K +E            L   FSA I+ +       ++ ++   ++F PP+ +N          D    +L C WLS   L  +  ++  L +E +G  VL+   QFL+  TL +L            FG+                  +   + D   + D  +   L + + D+N    +  F++  + C++C   K G  C  F  C+HV+C AC  DYY +QI++G ++   C    C       +++ ++ +E F R+D+L+L   L        CPR  C+  V++E G   GIC  C + FC  CKM Y G   C  S  K++++    +             Y  +     LE+ E      EN KSCP C    +K +GCNK+TC+ C+ YFC+LC  +L +  PY H+
Sbjct:   11 DELLALASIYSEDEFKRSETAPGGEICVCLDLPPNFSAAIRGDSTAAAHTESFEDI--VSFLPPVILNFELPPGYPSTDPPAFTLSCKWLSPSQLALLCQRLDDLWEEYAGGVVLFAWMQFLKEGTLEYLKINSPYEIQVYGFGSQCIKNNSGISDSCSATGPAEAVIWDKRAIQDVESVAALIKCILDFNEAQQKKCFDSKSYMCNICFSEKLGSECTHFKDCQHVYCNACLKDYYTVQIQDGQVQALNCPEPKCSSVATPAQVKLLVGEELFSRYDRLLLQSSLDLMADVVYCPRPNCQTPVMLEPGGTMGICSNCNYAFCTLCKMTYHGVSACKLSAEKLMALRNEYLEADEAGKQFMEKRYGKRMIQKALEEMESKEWLEENAKSCPRCGTNIQKTEGCNKLTCTGCKQYFCWLCLGVLSRANPYSHY 440          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Xenopus
Match: ENSXETT00000028050.1 (pep primary_assembly:Xenopus_tropicalis_v9.1:KV460778.1:14948:28369:1 gene:ENSXETG00000005845.1 transcript:ENSXETT00000028050.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 150.214 bits (378), Expect = 3.474e-40
Identity = 117/412 (28.40%), Postives = 185/412 (44.90%), Query Frame = 2
Query:  107 EELEALVEIYTNLNYKLTEFYESLTIFFSADIKLNEFKELQIQ-NNQEFFK-----INFFPPISINLSFDKYSELLD---ISLLCIWLSDDLLETVRIKVISLLKE-SGDGVLWKCFQFLENETLTFL------------FGTHSNEFVLDIHRMIDETNGKLLYESLKDYNNRMNESTFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLK-FECM--ICGQDIENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPR--CEMTVLVE-GEEFGICPKCFFVFCIRCKMMYRGSCICN-SVVKMISIFGCLINCTNVYNIKFSNYLEKEEKVNA-EL-------ENYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHF 1231
            +EL AL  IY+   +K +E      I    D+  N    ++    + E+       ++F PPI ++          D    +L C WLS   L  +  ++ +L +E +G  VL+   QFL+  TL +L            FG    + + D   + D  +   L + + D+N    +  F++  + C +C   K G  C  F KC+H++C AC  DYY +QI++G ++   C    C       +++ ++ +E F R+D+L+L   L        CPR  C   V++E G E GIC  C + FC  CK+ Y     CN +  K++ +    +               K   V A E+       +N K CP C+   EKIDGCN+M C+ C   FC+LC  +L    PY HF
Sbjct:   11 DELLALASIYSEDEFKRSETAPGGEICVCLDLPPNFSVAIKGDCASNEYMGSFEDIVSFLPPIILDFELPPGYPSTDPPAFTLSCKWLSPSQLALLCQRLENLWEEYAGGVVLFAWMQFLKEGTLEYLKINSPYEIQLCEFGP---KLIWDKRAIQDVESVTALIDCILDFNEAQQKKFFDSKSYMCDICFSEKVGSECTHFKKCEHIYCNACLKDYYTVQIQDGQVQALNCPEPKCCSVATPAQVKLLVGEELFSRYDRLLLQSSLDLMADVVYCPRPNCRTPVMLEPGGEMGICSSCKYAFCTLCKLAYHAVAYCNITSEKLLLVRDEYLEADAAGKKLLERRYGKNVIVKAVEMRSFEWLEKNSKCCPSCRANVEKIDGCNRMFCTRCNKNFCWLCLAVLSNGDPYDHF 419          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Xenopus
Match: gpr156 (G protein-coupled receptor 156 [Source:Xenbase;Acc:XB-GENE-962217])

HSP 1 Score: 149.828 bits (377), Expect = 8.256e-40
Identity = 120/425 (28.24%), Postives = 185/425 (43.53%), Query Frame = 2
Query:  107 EELEALVEIYTNLNYKLTEFYESLTIFFSADIKLNEFKELQIQNNQEFFK--INFFPPISINLSFDKYSELLD---ISLLCIWLSDDLLETVRIKVISLLKE-SGDGVLWKCFQFLENETLTFL------------FG----------------THSNEFVLDIHRMIDETNG-KLLYESLKDYNNRMNESTFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLK-FEC--MICGQDIENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCP--RCEMTVLVE-GEEFGICPKCFFVFCIRCKMMYRGSCICN-SVVKMISI----FGCLINCTNVYNIKFSNYL---EKEEKVNAELE-NYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHF 1231
            +EL AL  IY+   +K +E      I    D+  N F +         F+  ++F PPI +N          D    +L C WLS   L  +  ++  L  E +G  VL+   QFL+  TL +L            FG                T   E V+   R+I +      L + + D+N    +  F++  + C++C + K G  C  F  C+HV+C AC  DYY +QI++G ++   C    C       +++ ++ +E F R+D+L+L   L        CP   C+   ++E G   GIC  C + FC  CKM Y G  +CN +  K+I +             +   ++  ++     E K    LE N + CP C  + +K  GCNKM C  C  YFC+LC  +L    PY HF
Sbjct:   11 DELLALASIYSEDEFKRSETAPGGEICVCLDLPPN-FSDCASNEYMGSFESIVSFLPPIILNFELPPGYPSTDPPAFTLSCKWLSPSQLVLLCQRLDDLWVEYAGGVVLFAWMQFLKEGTLEYLKINSPYEIQLCEFGSQCIKNNSGISDSCSATGPAEAVIWDKRVIQDVESVTTLIDCILDFNEAQQKKCFDSKSYMCNICFLGKLGSECTHFKDCQHVYCNACLKDYYTVQIQDGQVQALNCPEPKCSSVATPAQVKLLVGEELFSRYDRLLLQSSLDLMADVVYCPLLNCQTPFMLEPGGTMGICSNCNYAFCTLCKMAYHGVAVCNITTEKLILVREEYLEADAAGKKLLEKRYGKHMILKAVERKSTEWLETNTQQCPNCNASIQKDGGCNKMICRKCNKYFCWLCFAVLSTENPYDHF 434          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Xenopus
Match: znf347 (zinc finger protein 347 [Source:Xenbase;Acc:XB-GENE-6039618])

HSP 1 Score: 147.132 bits (370), Expect = 8.377e-39
Identity = 120/429 (27.97%), Postives = 186/429 (43.36%), Query Frame = 2
Query:  107 EELEALVEIYTNLNYKLTEFYESLTIFFSADIKLNEFKELQIQ-NNQEFFK-----INFFPPISINLSFDKYSELLD---ISLLCIWLSDDLLETVRIKVISLLKE-SGDGVLWKCFQFLENETLTFL------------FG----------------THSNEFVLDIHRMIDETNG-KLLYESLKDYNNRMNESTFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLK-FECM--ICGQDIENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPR--CEMTVLVE-GEEFGICPKCFFVFCIRCKMMYRGSCICN-SVVKMISIFGCLINCTNVYNIKFSNYLEKEEKVNA-EL-------ENYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHF 1231
            +EL AL  IY+   +K +E      I    D+  N    ++    + E+       ++F PPI ++          D    +L C WLS   L  +  ++ +L +E +G  VL+   QFL+  TL +L            FG                T   E V+   R I +      L + + D+N    +  F++  + C +C   K G  C  F KC+H++C AC  DYY +QI++G ++   C    C       +++ ++ +E F R+D+L+L   L        CPR  C   V++E G E GIC  C + FC  CK+ Y     CN +  K++ +    +               K   V A E+       +N K CP C+   EKIDGCN+M C+ C   FC+LC  +L    PY HF
Sbjct:   11 DELLALASIYSEDEFKRSETAPGGEICVCLDLPPNFSVAIKGDCASNEYMGSFEDIVSFLPPIILDFELPPGYPSTDPPAFTLSCKWLSPSQLALLCQRLENLWEEYAGGVVLFAWMQFLKEGTLEYLKINSPYEIQLCEFGPKCIRNNSGISDSCSATGPAEAVIWDKRAIQDVESVTALIDCILDFNEAQQKKFFDSKSYMCDICFSEKVGSECTHFKKCEHIYCNACLKDYYTVQIQDGQVQALNCPEPKCSSVATPAQVKLLVGEELFSRYDRLLLQSSLDLMADVVYCPRPNCRTPVMLEPGGEMGICSSCKYAFCTLCKLAYHAVAYCNITSEKLLLVRDEYLEADAAGKKLLERRYGKNVIVKAVEMRSFEWLEKNSKRCPSCRANVEKIDGCNRMFCTRCNKNFCWLCLAVLSNGDPYDHF 439          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Xenopus
Match: ENSXETT00000035372.1 (E3 ubiquitin-protein ligase RNF14-like [Source:NCBI gene;Acc:101732063])

HSP 1 Score: 140.969 bits (354), Expect = 1.469e-36
Identity = 119/429 (27.74%), Postives = 184/429 (42.89%), Query Frame = 2
Query:  107 EELEALVEIYTNLNYKLTEFYESLTIFFSADIKLNEFKELQIQ-NNQEFFK-----INFFPPISINLSFDKYSELLD---ISLLCIWLSDDLLETVRIKVISLLKE-SGDGVLWKCFQFLENETLTFL------------FG----------------THSNEFVL-DIHRMIDETNGKLLYESLKDYNNRMNESTFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLK-FECM--ICGQDIENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPR--CEMTVLVE-GEEFGICPKCFFVFCIRCKMMYRGSCICN-SVVKMISIFGCLINCTNVYNIKFSNYLEKEEKVNA-EL-------ENYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHF 1231
            +EL AL  IY+   +K  E      I    D+  N    ++    + E+       ++F PPI ++          D    +L C WLS   L  +  ++  L  E +G+ VL+   QFL+  TL +L            FG                T   E V+ D   + D  +   L + + D+N    +  F++  + C +C   K G  C  F KC+H++C AC  DYY +QI++G ++   C    C       +++ ++ +E F R+D+L+L   L        CPR  C   V++E G E GIC  C + FC  CK+ Y     CN +  K++ +    +               K   V A E+       +N K CP C+   EKIDGCN+M C+ C   FC+L   +L    PY HF
Sbjct:   10 DELLALSSIYSEDEFKRLETAPGGEICVCLDLPPNFSVAIKGDCASNEYMGSFEDIVSFLPPIILDFELPPGYPSTDPPAFTLSCKWLSPSQLALLCQRLDDLWVEYAGEVVLFAWMQFLKEGTLEYLKINSPYEIQLCEFGPKCIKNNLGISDSCSATGPAEAVIWDTRAIQDVESVTTLIDCILDFNEAQQKKCFDSKSYMCDICFSEKVGSECTHFKKCEHIYCNACLKDYYTVQIQDGQVQALNCPEPKCSSVATPAQVKLLVGEELFSRYDRLLLQSSLDLMADVVYCPRPNCRTPVMLEPGGEMGICSSCKYAFCTLCKLAYHAVAYCNITSEKLLLVRDEYLEADAAGKKLLERRYGKNVIVKAVEMRSFEWLEKNSKRCPSCRANVEKIDGCNRMFCTRCNKNFCWLYLAVLSNGDPYDHF 438          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Mouse
Match: Rnf14 (ring finger protein 14 [Source:MGI Symbol;Acc:MGI:1929668])

HSP 1 Score: 154.836 bits (390), Expect = 1.458e-41
Identity = 127/446 (28.48%), Postives = 194/446 (43.50%), Query Frame = 2
Query:  107 EELEALVEIYTNLNYKLTEFYESLTIFFSADIKLNEFK-------ELQIQNNQEFFKINFFPPISINLSFDKYSELLD---ISLLCIWLSDDLLETVRIKVISLLKE-SGDGVLWKCFQFLENETLTFL---------FGTH---------------------------SNEFVLDIHRMIDETNGKLLYESLKDYNNRMNESTFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFECMICGQD-----IENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPR--CEMTVLVE-GEEFGICPKCFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVY---NIKFSNYLEKE------EKVNAELE-------NYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHF 1231
            +EL AL  IY    ++  E  +        D+  N FK          +QN+   + I F PP+ +N               +L   WLS   L  +   + +L +E  G  VL+   QFL+ ETLT+L          G+                              E  +D   + D  +   L + + D+N       FN+ +F CS+C   K G +C+ F +CKHV+C AC  DY++IQIK+G +K  C+ C +          ++++++  + F R+D+L+L   L        CPR  C++ V+ E G    IC  C F FC  C++ Y G   C    +       LI+  N Y   +     +LE+       +K   E+E       N KSCP C    +K+DGCNKMTC+ C  YFC++C   L +  PY+HF
Sbjct:   11 DELLALASIYDADEFRKAESVQGGETRIYLDLPQN-FKIFVSGNSNESLQNSGFEYTICFLPPLVLNFELPPDYPSSSPPSFTLSGKWLSPTQLSALCKHLDNLWEEHRGRVVLFAWMQFLKEETLTYLNIVSPFELKMGSQKKVQRRATAQASSSTELGVGGAAAADVDQEETVDERAVQDVESLSSLIQEILDFNQARQTKCFNSKLFLCSICFCEKLGSDCMYFLECKHVYCKACLKDYFEIQIKDGQVK--CLNCPEPQCPSVATPGQVKELVEADLFARYDRLLLQSTLDLMADVVYCPRPCCQLPVMQEPGGTMAICSSCNFAFCTLCRLTYHGLSPCKVTAEK------LIDLRNEYLQADEATKRFLEQRYGKRVIQKALEEMESKDWLEKNSKSCPCCGTPIQKLDGCNKMTCTGCMQYFCWICMGSLSRANPYRHF 447          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Mouse
Match: Rnf14 (ring finger protein 14 [Source:MGI Symbol;Acc:MGI:1929668])

HSP 1 Score: 154.836 bits (390), Expect = 1.458e-41
Identity = 127/446 (28.48%), Postives = 194/446 (43.50%), Query Frame = 2
Query:  107 EELEALVEIYTNLNYKLTEFYESLTIFFSADIKLNEFK-------ELQIQNNQEFFKINFFPPISINLSFDKYSELLD---ISLLCIWLSDDLLETVRIKVISLLKE-SGDGVLWKCFQFLENETLTFL---------FGTH---------------------------SNEFVLDIHRMIDETNGKLLYESLKDYNNRMNESTFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFECMICGQD-----IENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPR--CEMTVLVE-GEEFGICPKCFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVY---NIKFSNYLEKE------EKVNAELE-------NYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHF 1231
            +EL AL  IY    ++  E  +        D+  N FK          +QN+   + I F PP+ +N               +L   WLS   L  +   + +L +E  G  VL+   QFL+ ETLT+L          G+                              E  +D   + D  +   L + + D+N       FN+ +F CS+C   K G +C+ F +CKHV+C AC  DY++IQIK+G +K  C+ C +          ++++++  + F R+D+L+L   L        CPR  C++ V+ E G    IC  C F FC  C++ Y G   C    +       LI+  N Y   +     +LE+       +K   E+E       N KSCP C    +K+DGCNKMTC+ C  YFC++C   L +  PY+HF
Sbjct:   11 DELLALASIYDADEFRKAESVQGGETRIYLDLPQN-FKIFVSGNSNESLQNSGFEYTICFLPPLVLNFELPPDYPSSSPPSFTLSGKWLSPTQLSALCKHLDNLWEEHRGRVVLFAWMQFLKEETLTYLNIVSPFELKMGSQKKVQRRATAQASSSTELGVGGAAAADVDQEETVDERAVQDVESLSSLIQEILDFNQARQTKCFNSKLFLCSICFCEKLGSDCMYFLECKHVYCKACLKDYFEIQIKDGQVK--CLNCPEPQCPSVATPGQVKELVEADLFARYDRLLLQSTLDLMADVVYCPRPCCQLPVMQEPGGTMAICSSCNFAFCTLCRLTYHGLSPCKVTAEK------LIDLRNEYLQADEATKRFLEQRYGKRVIQKALEEMESKDWLEKNSKSCPCCGTPIQKLDGCNKMTCTGCMQYFCWICMGSLSRANPYRHF 447          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Mouse
Match: Rnf14 (ring finger protein 14 [Source:MGI Symbol;Acc:MGI:1929668])

HSP 1 Score: 154.836 bits (390), Expect = 1.458e-41
Identity = 127/446 (28.48%), Postives = 194/446 (43.50%), Query Frame = 2
Query:  107 EELEALVEIYTNLNYKLTEFYESLTIFFSADIKLNEFK-------ELQIQNNQEFFKINFFPPISINLSFDKYSELLD---ISLLCIWLSDDLLETVRIKVISLLKE-SGDGVLWKCFQFLENETLTFL---------FGTH---------------------------SNEFVLDIHRMIDETNGKLLYESLKDYNNRMNESTFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFECMICGQD-----IENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPR--CEMTVLVE-GEEFGICPKCFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVY---NIKFSNYLEKE------EKVNAELE-------NYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHF 1231
            +EL AL  IY    ++  E  +        D+  N FK          +QN+   + I F PP+ +N               +L   WLS   L  +   + +L +E  G  VL+   QFL+ ETLT+L          G+                              E  +D   + D  +   L + + D+N       FN+ +F CS+C   K G +C+ F +CKHV+C AC  DY++IQIK+G +K  C+ C +          ++++++  + F R+D+L+L   L        CPR  C++ V+ E G    IC  C F FC  C++ Y G   C    +       LI+  N Y   +     +LE+       +K   E+E       N KSCP C    +K+DGCNKMTC+ C  YFC++C   L +  PY+HF
Sbjct:   11 DELLALASIYDADEFRKAESVQGGETRIYLDLPQN-FKIFVSGNSNESLQNSGFEYTICFLPPLVLNFELPPDYPSSSPPSFTLSGKWLSPTQLSALCKHLDNLWEEHRGRVVLFAWMQFLKEETLTYLNIVSPFELKMGSQKKVQRRATAQASSSTELGVGGAAAADVDQEETVDERAVQDVESLSSLIQEILDFNQARQTKCFNSKLFLCSICFCEKLGSDCMYFLECKHVYCKACLKDYFEIQIKDGQVK--CLNCPEPQCPSVATPGQVKELVEADLFARYDRLLLQSTLDLMADVVYCPRPCCQLPVMQEPGGTMAICSSCNFAFCTLCRLTYHGLSPCKVTAEK------LIDLRNEYLQADEATKRFLEQRYGKRVIQKALEEMESKDWLEKNSKSCPCCGTPIQKLDGCNKMTCTGCMQYFCWICMGSLSRANPYRHF 447          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Mouse
Match: Rnf14 (ring finger protein 14 [Source:MGI Symbol;Acc:MGI:1929668])

HSP 1 Score: 143.28 bits (360), Expect = 2.928e-38
Identity = 90/276 (32.61%), Postives = 138/276 (50.00%), Query Frame = 2
Query:  476 NEFVLDIHRMIDETNGKLLYESLKDYNNRMNESTFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFECMICGQD-----IENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPR--CEMTVLVE-GEEFGICPKCFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVY---NIKFSNYLEKE------EKVNAELE-------NYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHF 1231
             E  +D   + D  +   L + + D+N       FN+ +F CS+C   K G +C+ F +CKHV+C AC  DY++IQIK+G +K  C+ C +          ++++++  + F R+D+L+L   L        CPR  C++ V+ E G    IC  C F FC  C++ Y G   C    +       LI+  N Y   +     +LE+       +K   E+E       N KSCP C    +K+DGCNKMTC+ C  YFC++C   L +  PY+HF
Sbjct:   54 QEETVDERAVQDVESLSSLIQEILDFNQARQTKCFNSKLFLCSICFCEKLGSDCMYFLECKHVYCKACLKDYFEIQIKDGQVK--CLNCPEPQCPSVATPGQVKELVEADLFARYDRLLLQSTLDLMADVVYCPRPCCQLPVMQEPGGTMAICSSCNFAFCTLCRLTYHGLSPCKVTAEK------LIDLRNEYLQADEATKRFLEQRYGKRVIQKALEEMESKDWLEKNSKSCPCCGTPIQKLDGCNKMTCTGCMQYFCWICMGSLSRANPYRHF 321          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Mouse
Match: Arih2 (ariadne RBR E3 ubiquitin protein ligase 2 [Source:MGI Symbol;Acc:MGI:1344361])

HSP 1 Score: 65.4698 bits (158), Expect = 6.311e-11
Identity = 58/244 (23.77%), Postives = 104/244 (42.62%), Query Frame = 2
Query:  485 VLDIHRMIDETNGKLLYESLKDYNNRMNESTFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNG-NLKFECMICGQDIENLE--IRKVMTKEEF-ERWDKLILNQCLKEEKSFYNCPRCEMTVLVEGEEFGI----CPKCFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVYNIKFSNYLEKEEKVNAELENYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLC 1192
            +LD +R     + +LL E+    N   +  T +     C+VC    R  N +    C+H FC +C   +  + +K+G  +   CM     +   E  +  ++  EE  +++ + +    ++       CP  +  +++  +E       C +C  VFC +C+ MY     C ++ K       L  C +  + + +NY+           + K CP C    EK  GCN M CS C+  FC++C
Sbjct:  104 ILDRYR---SNSAQLLVEARVQPNPSKHVPTAH-PPHHCAVCMQFVRKENLLSLA-CQHQFCRSCWEQHCSVLVKDGVGVGISCMAQDCPLRTPEDFVFPLLPNEELRDKYRRYLFRDYVESHFQLQLCPGADCPMVIRVQEPRARRVQCNRCSEVFCFKCRQMYHAPTDCATIRKW------LTKCAD--DSETANYISA---------HTKDCPKCNICIEKNGGCNHMQCSKCKHDFCWMC 325          
BLAST of RBR-type E3 ubiquitin transferase vs. UniProt/SwissProt
Match: sp|Q9JI90|RNF14_MOUSE (E3 ubiquitin-protein ligase RNF14 OS=Mus musculus OX=10090 GN=Rnf14 PE=1 SV=2)

HSP 1 Score: 154.836 bits (390), Expect = 1.020e-40
Identity = 127/446 (28.48%), Postives = 194/446 (43.50%), Query Frame = 2
Query:  107 EELEALVEIYTNLNYKLTEFYESLTIFFSADIKLNEFK-------ELQIQNNQEFFKINFFPPISINLSFDKYSELLD---ISLLCIWLSDDLLETVRIKVISLLKE-SGDGVLWKCFQFLENETLTFL---------FGTH---------------------------SNEFVLDIHRMIDETNGKLLYESLKDYNNRMNESTFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFECMICGQD-----IENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPR--CEMTVLVE-GEEFGICPKCFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVY---NIKFSNYLEKE------EKVNAELE-------NYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHF 1231
            +EL AL  IY    ++  E  +        D+  N FK          +QN+   + I F PP+ +N               +L   WLS   L  +   + +L +E  G  VL+   QFL+ ETLT+L          G+                              E  +D   + D  +   L + + D+N       FN+ +F CS+C   K G +C+ F +CKHV+C AC  DY++IQIK+G +K  C+ C +          ++++++  + F R+D+L+L   L        CPR  C++ V+ E G    IC  C F FC  C++ Y G   C    +       LI+  N Y   +     +LE+       +K   E+E       N KSCP C    +K+DGCNKMTC+ C  YFC++C   L +  PY+HF
Sbjct:   11 DELLALASIYDADEFRKAESVQGGETRIYLDLPQN-FKIFVSGNSNESLQNSGFEYTICFLPPLVLNFELPPDYPSSSPPSFTLSGKWLSPTQLSALCKHLDNLWEEHRGRVVLFAWMQFLKEETLTYLNIVSPFELKMGSQKKVQRRATAQASSSTELGVGGAAAADVDQEETVDERAVQDVESLSSLIQEILDFNQARQTKCFNSKLFLCSICFCEKLGSDCMYFLECKHVYCKACLKDYFEIQIKDGQVK--CLNCPEPQCPSVATPGQVKELVEADLFARYDRLLLQSTLDLMADVVYCPRPCCQLPVMQEPGGTMAICSSCNFAFCTLCRLTYHGLSPCKVTAEK------LIDLRNEYLQADEATKRFLEQRYGKRVIQKALEEMESKDWLEKNSKSCPCCGTPIQKLDGCNKMTCTGCMQYFCWICMGSLSRANPYRHF 447          
BLAST of RBR-type E3 ubiquitin transferase vs. UniProt/SwissProt
Match: sp|Q9UBS8|RNF14_HUMAN (E3 ubiquitin-protein ligase RNF14 OS=Homo sapiens OX=9606 GN=RNF14 PE=1 SV=1)

HSP 1 Score: 149.828 bits (377), Expect = 6.042e-39
Identity = 122/439 (27.79%), Postives = 191/439 (43.51%), Query Frame = 2
Query:  107 EELEALVEIYTNLNYKLTEFYESLTIFFSADIKLNEFKELQ-------IQNNQEFFKINFFPPISINLSFDKYSELLD---ISLLCIWLSDDLLETVRIKVISLLKE-SGDGVLWKCFQFLENETLTFL------------------------------FGTHSN-----EFVLDIHRMIDETNGKLLYESLKDYNNRMNESTFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFECMICGQD-----IENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPR--CEMTVLVE-GEEFGICPKCFFVFCIRCKMMYRGSCICN-SVVKMISIFGCLINCTNVYNIKFSNYLEKE--EKVNAELE-------NYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHF 1231
            +EL AL  IY    ++  E  +        D+  N FK          +QN+   + I F PP+ +N               +L   WLS   L  +   + +L +E  G  VL+   QFL+ ETL +L                              FG  +      E ++D   + D  +   L + + D++       FN+ +F CS+C   K G  C+ F +C+HV+C AC  DY++IQI++G +  +C+ C +          ++++++  E F R+D+L+L   L        CPR  C++ V+ E G   GIC  C F FC  C++ Y G   C  +  K++ +    +               K   +K   E+E       N KSCP C    EK+DGCNKMTC+ C  YFC++C   L +  PY+HF
Sbjct:   11 DELLALASIYDGDEFRKAESVQGGETRIYLDLPQN-FKIFVSGNSNECLQNSGFEYTICFLPPLVLNFELPPDYPSSSPPSFTLSGKWLSPTQLSALCKHLDNLWEEHRGSVVLFAWMQFLKEETLAYLNIVSPFELKIGSQKKVQRRTAQASPNTELDFGGAAGSDVDQEEIVDERAVQDVESLSNLIQEILDFDQAQQIKCFNSKLFLCSICFCEKLGSECMYFLECRHVYCKACLKDYFEIQIRDGQV--QCLNCPEPKCPSVATPGQVKELVEAELFARYDRLLLQSSLDLMADVVYCPRPCCQLPVMQEPGCTMGICSSCNFAFCTLCRLTYHGVSPCKVTAEKLMDLRNEYLQADEANKRLLDQRYGKRVIQKALEEMESKEWLEKNSKSCPCCGTPIEKLDGCNKMTCTGCMQYFCWICMGSLSRANPYKHF 446          
BLAST of RBR-type E3 ubiquitin transferase vs. UniProt/SwissProt
Match: sp|Q9US46|ITT1_SCHPO (E3 ubiquitin-protein ligase itt1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=itt1 PE=3 SV=1)

HSP 1 Score: 88.5817 bits (218), Expect = 1.032e-17
Identity = 75/279 (26.88%), Postives = 124/279 (44.44%), Query Frame = 2
Query:  548 DYNNRMNESTFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNL-KFEC--MICGQDIENL---EIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPR--CEMTVLVE-GEEFGICPKCFFVFCIRCKMMYRGSC----ICNSVVKMISIF--------GCLINCTNVYNIKFSNYLEKEEKVNAELE-----NYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHFG-LAPNCYXXXXXXXXXXXXXKGNW 1303
            D N ++ E  F    F C+VC     G +C + T+C HV C +C  DYY + I+ G   + +C  + CG+D   L   E+  ++  +   R+ +L   +  + + +   CPR  C+     + G++  IC KC F FC  C+  + G      +     K++ ++           +     Y  +  + L ++ K + E E     N + CP C +  E+IDGC  M C  C  +FC+LC   L +  PY+HF     +CY      +A       NW
Sbjct:  159 DKNAKLLE--FQIRKFQCNVCFDEFNGTDCFQLTRCGHVSCQSCLRDYYTMCIQEGMFSQIKCIDLDCGKDAPVLTLKELESIVGVQLTNRYKELEEKRRYENDSNIIFCPRSFCQGPSKRDPGQKLAICQKCDFAFCSFCQATWHGDLSPCKLEGDSKKLVEMYLNYQENEPEKALELEKRYGKRIIDRLVEQVKNDEEAEKWVLLNGQRCPTCDRVVERIDGCCHMNC-LCGTHFCFLCGAYLMEQNPYKHFNDPVSSCYGMLFASAAEKQRFSENW 434          
BLAST of RBR-type E3 ubiquitin transferase vs. UniProt/SwissProt
Match: sp|Q04638|ITT1_YEAST (Translation termination inhibitor protein ITT1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=ITT1 PE=1 SV=1)

HSP 1 Score: 74.3294 bits (181), Expect = 5.430e-13
Identity = 87/381 (22.83%), Postives = 144/381 (37.80%), Query Frame = 2
Query:  311 LLDISLLCIWLSDDLLETVRIKVISLLKESGD----------GVLWKCFQFLENETLTFLFGTHSNEFVLDIHRMIDETNGKLLYESLKDYNNRMNESTFNNSIFDCSVCTIAKRGINCV----EFTKCKHVFCLACAHDYYDIQIKNGNLK-FECMICGQDIENLE---------------------IRKVMTKEEFERWDKLILNQCLKEEKSF-----YNCPRCEMTVLVEGEEFGI--CPKCFFVFCIRCKMMYRGSCICNSVVKMISIFGCLIN--------------------CTNVYNIKFSNYLEK---EEKVNAELENYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHFGLA-PNCY 1252
            ++DI  L  W+S D  + +  K + L++E+ D           +L   F FL ++T   LF          I + + +      Y+  K  +        + S + C +C   ++G+  +    E    +H  C  CA  Y+   I+   +    C  C      LE                     +++V+  E  ER++K+  NQ       +       C RC+     E  +  +  C KC FVFC  C   + G    N   K +S+   +I                        V  ++ ++YL +   +  +  E  N + CP CK   E+ +GCNKM C  C   FC++C  +L    PY+HF  A   CY
Sbjct:   87 VMDIKSL--WISTDEKKMLIDKALRLVEETVDMSIEFADSFTSILILIFGFLIDDTAILLFPN-------GIRKCLTQDQ----YDLFKQISEEATLQKVSRSNYHCCICMEMEKGVRMIKLPCENANVEHYLCRGCAKSYFTAMIQENRISSVRCPQCEYKELKLEDFKSYKKMLKALFTPLIPVSFLKEVIDTELCERYEKMFYNQAATRLSKYCPYACVTCRRCDSWCTKEDLDDAMIQCQKCHFVFCFDCLHAWHG--YNNKCGKKVSLSTDIIEEYLDDTVTSYERKRKLEAKYGRRVLELEVNDYLAEKMLDLAIKKEGSNLQRCPKCKVVVERSEGCNKMKCEVCGTLFCFICGVLLYPEDPYEHFREAYSGCY 452          
BLAST of RBR-type E3 ubiquitin transferase vs. UniProt/SwissProt
Match: sp|Q9SKC3|ARI9_ARATH (Probable E3 ubiquitin-protein ligase ARI9 OS=Arabidopsis thaliana OX=3702 GN=ARI9 PE=2 SV=1)

HSP 1 Score: 70.8626 bits (172), Expect = 8.176e-12
Identity = 68/241 (28.22%), Postives = 97/241 (40.25%), Query Frame = 2
Query:  527 LLYESLKDYNNRMNESTFNNSIFDCSVC--TIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGN--LKFECM--ICGQDIENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPR--CEMTVLVEGEE---FGICPKCFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVYNIKFSNYLEKEEKVNAELENYKSCPGCKQAFEKIDGCNKMTCSY-CRIYFCYLCRKILDKH 1213
            LL E + D+N    +         C +C  +  +  I  V    C H +C  C   Y   +I++G   L+ +C    C   +    I  V   +  E++ + IL   +++ K    CP   C   V   G E   + +   C + FC  C         C++V K I                F N  E E K N  L N K CP CK+  EK DGCN MTCS  C   FC++C K   +H
Sbjct:  104 LLKEPVVDFNGGEKDKKCRKVNIQCGICFESYTREEIARV---SCGHPYCKTCWAGYITTKIEDGPGCLRVKCPEPSCSAAVGKDMIEDVTETKVNEKYSRYILRSYVEDGKKIKWCPSPGCGYAVEFGGSESSSYDVSCLCSYRFCWNCSEDAHSPVDCDTVSKWI----------------FKNQDESENK-NWMLANSKPCPECKRPIEKNDGCNHMTCSAPCGHEFCWICLKAYRRH 324          
BLAST of RBR-type E3 ubiquitin transferase vs. TrEMBL
Match: A0A401P327 (RBR-type E3 ubiquitin transferase OS=Scyliorhinus torazame OX=75743 GN=scyTo_0005143 PE=3 SV=1)

HSP 1 Score: 176.022 bits (445), Expect = 4.125e-46
Identity = 128/449 (28.51%), Postives = 201/449 (44.77%), Query Frame = 2
Query:  107 EELEALVEIYTNLNYKLTEFYESLTIFFSADIKLNEFKEL----QIQNNQEFFK--INFFPPISINLSFDK---YSELLDISLLCIWLSDDLLETVRIKVISLLKESGD-GVLWKCFQFLENETLTFLF----------------GTHSN----------------EFVLDIHRMIDETNGKLLYESLKDYNNRMNESTFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFECMICGQD-----IENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPR--CEMTVLVE-GEEFGICPKCFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVYNIKFSNYLEKEEKVNAELE-----------------------NYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHFG 1234
            +EL AL  IY    +K  E      I    ++  N FK +    + QN ++  +  ++F PP+ +N               +L C WL    L  + + +  + K++G+  VL+   QFL+ ETL+FL                 GT+SN                EF LD   + D  +   +   + D++    +  FN+ +F CSVC   K GI+C+ F +CKHV+C AC  +Y++IQI++GN+  +C+ C +          ++++++ +E F R+D+L+L   L        CPR  C+  V++E G   G CP C + FC  C+M Y G   C    + +S                  YL+ +E     LE                       N K CP C    +K++GCNKMTC+ C+ YFC+LC + L K  PY HF 
Sbjct:   12 DELLALASIYEEDEFKRAESAPGGEISICLELPPN-FKVIVHGDEKQNKKDLIEYVVSFLPPLVLNFELPPDYPSGSAPKYTLSCKWLFQAQLSVLCVHLDRIWKDNGNCVVLFSWMQFLKEETLSFLLIKSPLEIQGNSEKKSDGTYSNNKDKEFGSRNKPKNLKEFPLDPRAIQDVESWACVLREILDFDQNQQQKVFNSKMFTCSVCFYEKLGIDCMHFKECKHVYCKACLKEYFEIQIRDGNV--QCLNCPEPKCTSIATPAQVKELVREETFARYDRLLLQSTLDLMTDVVYCPRTVCKSVVMLEPGNTMGFCPGCRYAFCALCEMAYHGISPCRLRAEKLSALR-------------DEYLKADESGRQRLEKSYGRRVLQKAVEELCSQEWLDKNSKPCPRCGTNIQKVNGCNKMTCTGCKQYFCWLCIRPLSKVNPYSHFS 444          
BLAST of RBR-type E3 ubiquitin transferase vs. TrEMBL
Match: Q1RL49 (RBR-type E3 ubiquitin transferase OS=Ciona intestinalis OX=7719 GN=Ci-ZF(RING/C6HC)-7 PE=2 SV=1)

HSP 1 Score: 167.548 bits (423), Expect = 4.285e-43
Identity = 111/376 (29.52%), Postives = 186/376 (49.47%), Query Frame = 2
Query:  236 NNQEFFKINFFPPISINLSF-DKYS--ELLDISLLCIWLSDDLLETVRIKVISLL-KESGDGVLWKCFQFLENETLTFLFGTHSNEFVLD---------------------IHRMIDETNG-KLLYESLKDYNNRMNESTFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFECMICGQ---DIENL--EIRKVMTKEEFERWDKLILNQCLKEEKSFYNCP--RCEMTVLVEGE-EFGICPKCFFVFCIRCKMMYRGSCIC----NSVVKMISIFGCL-----INCTNVYNIKFSNYLEKEEKVNAELEN-YKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHF 1231
            +N+E F ++F PPI +N +  D Y   E    +L C+WLS   L  + +K+  +  KE G+ +L++ FQFL++++L+ L G + N  + D                       R +   +    +  +L +Y+ +  +  F  S+F C++C + K+G +C++F  C HV+C  C   Y++I I  G +    +IC +   D   L  ++++ + K+ +ER++KL+L   L        CP   C+  V++E E   G CP C + FC+ CK+ Y G   C    + ++K+   +              Y  K       +    A + N  K CPGC  + EK+DGCNKMTC  CR YFC++C  +LD   PY+H+
Sbjct:   58 HNKEHF-VSFLPPIQLNFALSDGYPSDEPPQFNLSCVWLSPSQLYELCLKLDEIWQKEEGNVILYEWFQFLQDDSLSIL-GINDNLHICDEFESSSQSSTIASSKPGINKPCKRGLQTAHSYAEILPTLLNYDQQKQQEIFFTSVFSCNICFVDKKGTDCLQFKDCGHVYCKQCITSYFEIHISEGTIT--SLICPEPDCDTTALPNQVKEAVNKDLYERYEKLLLQTTLDTMTDIVFCPLMHCQSAVIIEPEASIGQCPSCAYAFCVHCKLAYHGVSPCKIASHEIIKLCKEYESANEEKKKQMEKKYGRKVLCKALDDRATQAWMNNNTKPCPGCNASIEKLDGCNKMTCYKCRAYFCWICMHVLDCANPYRHY 429          
BLAST of RBR-type E3 ubiquitin transferase vs. TrEMBL
Match: R4GDE8 (RBR-type E3 ubiquitin transferase OS=Anolis carolinensis OX=28377 GN=RNF14 PE=3 SV=1)

HSP 1 Score: 165.236 bits (417), Expect = 3.770e-42
Identity = 131/440 (29.77%), Postives = 192/440 (43.64%), Query Frame = 2
Query:  107 EELEALVEIYTNLNYK------------LTEFYESLTIFFSADIKLNEFKELQIQNNQEFFKINFFPPISINLSFDK-YSELLD--ISLLCIWLSDDLLETVRIKVISLLKESGDG--VLWKCFQFLENETLTFL------------------------------FGTHSNEFVLDIHRMIDETNGKLLYESLKDYNNRMNESTFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFECMICGQ-----DIENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPR--CEMTVLVEGE-EFGICPKCFFVFCIRCKMMYRGSCICN-SVVKMISIFGCLINCTNVYNIKFSNYLEKE--EKVNAELE-------NYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHF 1231
            +EL AL  IY    +K            L +  E  T+ +S D K N      +QN++    ++F PPI +N  F   Y  +     +L   WLS + L T R K +  L E   G  VL+   QFL+ ETL  L                               G    E  L+   + D  +   L   + D+++   E  FN  + DC +C   K G  C+ F  C+HV+C AC  DY++IQI++G +   C+ C +          ++++++ ++ F R+D+L+L   L        CPR  C+  V+ E     GIC  C + FC  CKM Y G   C  S  K++ +    +   +           K   +K   E+E       N KSCP C    EK+DGCNKMTCS C  +FC+ C   L K RPY+HF
Sbjct:   11 DELLALASIYDEDEFKRAPSGCGGEIRVLVDLPEDFTLLWSGDQKEN------LQNSKFECTVSFLPPIVLNFEFPADYPSISPPAFTLSSKWLSQEQL-TARCKHLDTLWEENRGSVVLFAWIQFLKEETLDCLNIASPYEPKIYGQEPEQNGTIQEDASNGATGGAMEQEESLNGRTVQDVGSLSTLIREIIDFDHAHQEKCFNTKMHDCKICFSEKLGSECMYFLDCRHVYCKACLKDYFEIQIRDGQV--HCLNCPELKCLSVATPGQVKELVEEKLFARYDRLLLQSTLDLMADMVYCPRPGCQTPVMQEPSCTMGICSSCNYAFCTLCKMTYHGVSPCKISAEKLVQLREEYLAADDTTKKFLEQRYGKRVIQKALEEMESKEWLETNSKSCPSCGTPIEKLDGCNKMTCSVCNKHFCWCCMGSLSKARPYEHF 441          
BLAST of RBR-type E3 ubiquitin transferase vs. TrEMBL
Match: G1KNM7 (RBR-type E3 ubiquitin transferase OS=Anolis carolinensis OX=28377 GN=RNF14 PE=3 SV=2)

HSP 1 Score: 164.851 bits (416), Expect = 4.617e-42
Identity = 131/440 (29.77%), Postives = 192/440 (43.64%), Query Frame = 2
Query:  107 EELEALVEIYTNLNYK------------LTEFYESLTIFFSADIKLNEFKELQIQNNQEFFKINFFPPISINLSFDK-YSELLD--ISLLCIWLSDDLLETVRIKVISLLKESGDG--VLWKCFQFLENETLTFL------------------------------FGTHSNEFVLDIHRMIDETNGKLLYESLKDYNNRMNESTFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFECMICGQ-----DIENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPR--CEMTVLVEGE-EFGICPKCFFVFCIRCKMMYRGSCICN-SVVKMISIFGCLINCTNVYNIKFSNYLEKE--EKVNAELE-------NYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHF 1231
            +EL AL  IY    +K            L +  E  T+ +S D K N      +QN++    ++F PPI +N  F   Y  +     +L   WLS + L T R K +  L E   G  VL+   QFL+ ETL  L                               G    E  L+   + D  +   L   + D+++   E  FN  + DC +C   K G  C+ F  C+HV+C AC  DY++IQI++G +   C+ C +          ++++++ ++ F R+D+L+L   L        CPR  C+  V+ E     GIC  C + FC  CKM Y G   C  S  K++ +    +   +           K   +K   E+E       N KSCP C    EK+DGCNKMTCS C  +FC+ C   L K RPY+HF
Sbjct:   11 DELLALASIYDEDEFKRAPSGCGGEIRVLVDLPEDFTLLWSGDQKEN------LQNSKFECTVSFLPPIVLNFEFPADYPSISPPAFTLSSKWLSQEQL-TARCKHLDTLWEENRGSVVLFAWIQFLKEETLDCLNIASPYEPKIYGQEPEQNGTIQEDASNGATGGAMEQEESLNGRTVQDVGSLSTLIREIIDFDHAHQEKCFNTKMHDCKICFSEKLGSECMYFLDCRHVYCKACLKDYFEIQIRDGQV--HCLNCPELKCLSVATPGQVKELVEEKLFARYDRLLLQSTLDLMADMVYCPRPGCQTPVMQEPSCTMGICSSCNYAFCTLCKMTYHGVSPCKISAEKLVQLREEYLAADDTTKKFLEQRYGKRVIQKALEEMESKEWLETNSKSCPSCGTPIEKLDGCNKMTCSVCNKHFCWCCMGSLSKARPYEHF 441          
BLAST of RBR-type E3 ubiquitin transferase vs. TrEMBL
Match: A0A3Q0K3F8 (RBR-type E3 ubiquitin transferase OS=Ciona intestinalis OX=7719 GN=zf(ring/c6hc)-7 PE=3 SV=1)

HSP 1 Score: 161.384 bits (407), Expect = 5.259e-41
Identity = 108/375 (28.80%), Postives = 180/375 (48.00%), Query Frame = 2
Query:  236 NNQEFFKINFFPPISINLSF-DKYS--ELLDISLLCIWLSDDLLETVRIKVISLLKESGDGVLWKCFQFLENETLTFLFGTHSNEFVLD---------------------IHRMIDETNG-KLLYESLKDYNNRMNESTFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFECMICGQ---DIENL--EIRKVMTKEEFERWDKLILNQCLKEEKSFYNCP--RCEMTVLVEGE-EFGICPKCFFVFCIRCKMMYRGSCIC----NSVVKMISIFGCL-----INCTNVYNIKFSNYLEKEEKVNAELEN-YKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHF 1231
            +N+E F ++F PPI +N +  D Y   E    +L C+WLS               +E G+ +L++ FQFL++++L+ L G + N  + D                       R +   +    +  +L +Y+ +  +  F  S+F C++C + K+G +C++F  C HV+C  C   Y++I I  G +    +IC +   D   L  ++++ + K+ +ER++KL+L   L        CP   C+  V++E E   G CP C + FC+ CK+ Y G   C    + ++K+   +              Y  K       +    A + N  K CPGC  + EK+DGCNKMTC  CR YFC++C  +LD   PY+H+
Sbjct:   58 HNKEHF-VSFLPPIQLNFALSDGYPSDEPPQFNLSCVWLSPS-------------QEEGNVILYEWFQFLQDDSLSIL-GINDNLHICDEFESSSQSSTIASSKPGINKPCKRGLQTAHSYAEILPTLLNYDQQKQQEIFFTSVFSCNICFVDKKGTDCLQFKDCGHVYCKQCITSYFEIHISEGTIT--SLICPEPDCDTTALPNQVKEAVNKDLYERYEKLLLQTTLDTMTDIVFCPLMHCQSAVIIEPEASIGQCPSCAYAFCVHCKLAYHGVSPCKIASHEIIKLCKEYESANEEKKKQMEKKYGRKVLCKALDDRATQAWMNNNTKPCPGCNASIEKLDGCNKMTCYKCRAYFCWICMHVLDCANPYRHY 415          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Cavefish
Match: zmp:0000000524 (ring finger protein 14 [Source:NCBI gene;Acc:103046046])

HSP 1 Score: 157.532 bits (397), Expect = 7.090e-43
Identity = 117/424 (27.59%), Postives = 188/424 (44.34%), Query Frame = 2
Query:  107 EELEALVEIYTNLNYKLTEFYESLTIFFSADIKLNEFKELQIQNNQEFFKINFFPPISINLSFDK---YSELLDISLLCIWLSDDLLETVRIKVISLLKES-GDGVLWKCFQFLENETLTFL--------FGTHSN-------------------EFVLDIHRMIDETNGKLLYESLKDYNNRMNESTFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFECMICGQD-----IENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPR--CEMTVLVEGEE-FGICPKCFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVYNIKFSNYLEKEEKVNAELE----------NYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHF 1231
            +EL AL  IY    ++  E  +   I+   ++  N FK L        + ++F PP+ ++    +    +     +L   WLS   L  +  ++  L KE+ G  VL+   QFL+ ETL FL         G+ S+                   +  LD   +++      L   L D++    +  F+   F C +C   K G  C+ F +C+HV+C AC  +Y++IQI++GN+  +C+ C +          +++ ++ +++F R+D+L+L   L        CPR  C M V++E E   G+CP C + FC  CK  Y G   C      +          N    KF      ++ +   +E          N K+CP C    +K  GCNKMTCS C  YFC++C   L K  PY+HF
Sbjct:   10 DELLALASIYDEEEFRRAESGQEGEIYLCLELPPN-FKLLVNGERPVEYDVSFLPPLVLSFELPENYPSTSAPVFTLSSKWLSRLQLSALCKQLDKLWKENQGSVVLFTWIQFLKEETLEFLGLQSPLEITGSKSDRCKNEAAAKPAEGLEKRKQQQELDPRAVLEADPQADLLPQLLDFDEAQRQKVFDGKPFCCGICFSEKLGSGCMLFKECQHVYCKACMKEYFEIQIRDGNV--QCLNCPEPECTSVAMPSQVKLLVGEDDFARYDRLLLQSTLDRMADVMYCPRKTCCMAVMLEPETTMGLCPSCRYAFCTLCKRAYHGLSHCLPTADELRNLQEEYLAANKEEQKFMEQRYGKQVIQRAVEESFSRQWLEENSKNCPSCGTHIQKTQGCNKMTCSSCHQYFCWICLAPLSKVNPYKHF 430          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Cavefish
Match: rnf19b (ring finger protein 19B [Source:NCBI gene;Acc:103021791])

HSP 1 Score: 71.633 bits (174), Expect = 6.249e-13
Identity = 54/227 (23.79%), Postives = 93/227 (40.97%), Query Frame = 2
Query:  572 STFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFECMICGQDIENLEIRKVMTKEE-FERWDKLILNQCLKEEKSFYNCPR--CEMTVLVEGEEFGICPK-------CFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVYNIKFSNYLEKEEKVNAELENYKSCPGCKQAFEKI-DG-CNKMTCSYCRIYFCYLCRK-ILDKH 1213
            S     + +C +C + +      E   C H  CL C   Y  I+I    ++  C  C + +   ++  ++      E++++ +L +CL  +     CP   C   V+  G     CP+       C   FC  CK  +  +  C+S  +  ++          ++    +Y  ++       ++ K CP C     K+ DG CN MTC+ C   FC+LC K I D H
Sbjct:  104 SLGGQDLLECPLCLVRQPRDQLAELQGCSHRSCLCCLRQYLRIEITESRVQLSCPECAERLAPRQVALILDDPALLEKYEEFLLRRCLASDPDCRWCPAPDCGFAVIASG--CASCPRLVCRREGCGAEFCYHCKQAWHPNQTCDSARQQRALS------LRTHSTHSPSYTAEQ----GPTDDIKPCPRCGAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLH 318          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Cavefish
Match: si:ch211-278j3.3 (E3 ubiquitin-protein ligase RNF19B-like [Source:NCBI gene;Acc:103027424])

HSP 1 Score: 68.9366 bits (167), Expect = 4.537e-12
Identity = 51/219 (23.29%), Postives = 91/219 (41.55%), Query Frame = 2
Query:  590 IFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFECMICGQDIENLEIRKVMTKEEF-ERWDKLILNQCLKEEKSFYNCPRCEMTVLVEGEEFGICPK-------CFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVYNIKFSNYLEKEEKVNAELENYKSCPGCKQAFEKI-DG-CNKMTCSYCRIYFCYLC-RKILDKH 1213
            + +C +C +++   +    + C H  C  C   Y  I+I    +   C  C + +   ++R ++      ER+++  L + L  +     CP  + +  V       CPK       C   FC  C+ ++     C+   +  +      + + +Y   FS      E+   + E  K+CP C     K  DG CN+M C+ C   FC+LC ++I D H
Sbjct:  108 LVECPLCLLSQPRGHFPRLSSCPHRACADCLRQYLRIEISESRVGIACPQCPEALAPPDVRAILDDGALLERFEEFQLRRFLASDPDTRWCPAPDCSYAVIAYGCAECPKLSCGREGCDTEFCYHCRQLWHPDQTCDQARRQRARHTSGADASTLY--VFS------EEPGGDAEEIKACPRCGAYIMKTNDGSCNRMNCTVCACQFCWLCMQEITDVH 318          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Cavefish
Match: arih2 (ariadne RBR E3 ubiquitin protein ligase 2 [Source:NCBI gene;Acc:103035190])

HSP 1 Score: 64.3142 bits (155), Expect = 1.181e-10
Identity = 46/188 (24.47%), Postives = 83/188 (44.15%), Query Frame = 2
Query:  653 CKHVFCLACAHDYYDIQIKNG-NLKFECMI--CGQDIENLEIRKVMTKEEF-ERWDKLILNQCLKEEKSFYNCPRCEMTVLVEGEEFGI----CPKCFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVYNIKFSNYLEKEEKVNAELENYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLC 1192
            C+H FC +C   +  + +K+G  +   CM   C   +    +  ++  EE  E++ + +    ++       CP  +  ++++ +E       C +C  VFC +C+ MY     C ++ K       L  C +  + + +NY+           + K CP C    EK  GCN M CS C+  FC++C
Sbjct:  154 CQHSFCKSCWEQHCTVLVKDGVGVGISCMAQDCSLRMPEDFVLPLLPSEELKEKYRRYLFRDYVESHFQLQLCPGADCPIVIKVQEPRARRVQCSRCAEVFCFKCRQMYHAPTDCATIRKW------LTKCAD--DSETANYISA---------HTKDCPKCNICIEKNGGCNHMQCSKCKHDFCWMC 324          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Cavefish
Match: rnf217 (ring finger protein 217 [Source:NCBI gene;Acc:103021552])

HSP 1 Score: 54.299 bits (129), Expect = 1.790e-7
Identity = 50/230 (21.74%), Postives = 89/230 (38.70%), Query Frame = 2
Query:  590 IFDCSVCTIAK--RGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFECMI--CGQDIENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPRCEMTVLVEGEEFGI-----------CPKCFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVYNIKFSNYLEKEEKVNAELENYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHFG 1234
            +  C +C   +  R ++C     C+   C  C   Y   Q+  G     C I  C   +E   +   +  EE  ++   +  +  + + S   CP+C +   ++G                C KC FV+C +C   +     C    K   +              +++ +E  ++      N + CP CK   ++ +GC+ MTC+ C   FCY C    +K+R  + FG
Sbjct:  273 VLTCRICLDDRHSRPLHC-----CQKAVCEECLKTYISSQVLVGRTDIVCPITECSGFLEESVVVTHLASEELAKYKYFL--ELSRLDSSTKPCPQCSLFTSLKGRSLQAPSKAEHKYKIQCSKCQFVWCFKCHAPWHEGLKCREYRKGDKLL-----------RHWASVIEHGQR------NAQKCPRCKIHIQRTEGCDHMTCTQCNTNFCYRCG---EKYRHLRFFG 475          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Sea Lamprey
Match: zmp:0000000524 (zmp:0000000524 [Source:ZFIN;Acc:ZDB-GENE-130530-527])

HSP 1 Score: 145.591 bits (366), Expect = 6.203e-39
Identity = 113/397 (28.46%), Postives = 174/397 (43.83%), Query Frame = 2
Query:  266 FPPISINLSFD---KYSELLDISLLCIWLSDDLLETVRIKVISLLKES-GDGVLWKCFQFLENETLTFLF----------------------------------------GTHSNEFVLDIHRMIDETNGKLLYESLKDYNNRMNESTFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNL-KFECM--ICGQDIENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPR--CEMTVLVE-GEEFGICPKCFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVYNI--KFSN-------YLEKE----------EKVNAE---LENYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHFGLA 1240
             PP+ +N         +     ++ C WLS + L  +   +  L +E+ G  +L+   QFL+ +TL FL                                         G H     LD   +    +   LY  L DY+    +  F+  +F C +C   K G +CV  + C+HV+C  C   Y+ +QI+ GN+    C    C       ++R+++ +E F R+D+L+L   L        CPR  C+  VL+E  +  G CP+C F FC  C+  Y G            I  C+I   N+ NI  K++N       +LE+           E+V+++    +N K+CP C    +K+DGCNKMTCS C++YFC+LC K L +  PY HF  A
Sbjct:   72 LPPLVMNFELPSDYPSTSPPQFTISCKWLSREQLSWLCHTMDELWQENRGMEILYTWSQFLKEDTLDFLRIAPPLEVKSIAGGTTRKRDHGKTVRAEAGPEDLVKTAAVDGGHQPR-TLDPRAIQTCESWSSLYGELLDYDQAQRQKVFSARVFSCHICLCEKLGSSCVNLSGCEHVYCRDCLSAYFQLQIQEGNVHSLTCPEPKCQTVATPSQVRELVGEELFSRYDRLLLQSSLDLMADVVYCPRTSCQTPVLLEPNKTMGHCPQCKFAFCNVCRHAYHG------------ISACIIKSENLENILKKYNNADAASRAFLEQRYGKHTIKRAIEEVHSKDWLAQNAKACPRCCTNIQKVDGCNKMTCSSCQLYFCWLCLKELSRANPYSHFNEA 455          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Sea Lamprey
Match: rnf19a (ring finger protein 19A, RBR E3 ubiquitin protein ligase [Source:ZFIN;Acc:ZDB-GENE-030131-9414])

HSP 1 Score: 64.3142 bits (155), Expect = 2.510e-11
Identity = 55/224 (24.55%), Postives = 96/224 (42.86%), Query Frame = 2
Query:  581 NNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFECMICGQDIENLEIRKVMTKEEF-ERWDKLILNQCLKEEKSFYNCPR--CEMTVLVEGEEFGICPK-------CFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVYNIKFSNYLEKEEKVNAELENYKSCPGCKQAFEKI-DG-CNKMTCSYCRIYFCYLCRK-ILDKH 1213
             +   +C +C + +   +  E   C H  CL C   Y  I+I    +   C  C + +   +I++++       ++++ +L + L  +     CP   C   V+  G     CPK       C   FC  CK M+  +  C++  +  S          + +I+ ++    ++  +A+  + K CP C     K+ DG CN MTC+ C   FC+LC K I D H
Sbjct:  104 GSDALECPLCLVRRSAEHFPELLSCPHRSCLDCLRQYLRIEISESRVNICCPECAERLNPHDIQRILADATLMGKYEEFMLRRFLVADPDCRWCPAPDCGFAVIATG--CASCPKLTCEREGCGTEFCYHCKAMWHPNQTCDAARQQRSAT------LRLRSIQSASASYSQDGAHAD--DIKPCPRCAAYIMKMNDGSCNHMTCAVCGCEFCWLCMKEISDLH 317          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Sea Lamprey
Match: ankib1a (ankyrin repeat and IBR domain containing 1a [Source:NCBI gene;Acc:566524])

HSP 1 Score: 50.0618 bits (118), Expect = 8.270e-7
Identity = 51/213 (23.94%), Postives = 85/213 (39.91%), Query Frame = 2
Query:  650 KCKHVFCLACAHDYYDIQIKNGNLKFECMICGQ-------DIENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCP--RCEMTVLVEGEEFGI-------CPKCF-----FVFCIRCKMMYRGSCICNS----VVKMISIFGCLINCTNVYNIKFSNYLEKEEKVNAELENYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKH 1213
             C H+FC  C  +Y +++I+ G  K   ++C          IE +E+  ++ +E   R+ +  +   +    S   CP  RCE  V +               P          FC  C       C C +    + K++ +    ++  +V     +N L         + N K CP CK   +K DGCN M C+ C+  FC++C +   KH
Sbjct:  344 PCGHLFCKKCWEEYLNMKIQEG--KAHSILCPAYDCYSLVPIETIEV--LVCREMARRYLQFDIKAFVDTNPSIRWCPVPRCEQAVRLALPGAAGGSAARAHTPTAVDCGSGHTFCWECLGEAHEPCDCGTWKQWLQKIVDMKPEELSGVSVAAEDAANCLWL-------ISNSKPCPSCKSPIQKNDGCNHMQCTKCKHDFCWICLEEWKKH 545          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007741.1 (pep scaffold:Pmarinus_7.0:GL477427:676:25209:1 gene:ENSPMAG00000006996.1 transcript:ENSPMAT00000007741.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 49.2914 bits (116), Expect = 1.615e-6
Identity = 52/212 (24.53%), Postives = 77/212 (36.32%), Query Frame = 2
Query:  599 CSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNL-KFEC--MICGQDIENLEIRKVMT--KEEFERWDKLILNQCLKEEKSFYNCPR---CEMTVLVEGE--EFGICPKCFFVFCIRCKMMYRGSC--ICNSVVKMISIFGCLINCTNVYNIKFSNYLEKEEKVNAELENYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRK 1198
            C +C      +  +    C H  C +C   Y    I    L K  C  M C        IR +M    +  E + + +L   ++   +   C     C+  +  +G       C KC +  C  C  +    C   CN +   +   G        Y    S+ L K     A+L + K CP C    EK +GC  MTC+ C   FC+ C K
Sbjct: 1393 CPICLGVTGEVELLAPLYCTHRCCKSCWRAYLKTSIDQNMLAKCTCPIMDCPAQPTGAFIRTMMEDDSDRLELYKRALLRGYVESCSNLAWCANPQGCDRVLCKDGTGGHAATCAKCHWSTCFSCSFL-EAHCPASCNQIAWWVDEGG-------YYEGMSSDALSKHL---AKLIS-KPCPSCHAQIEKNEGCLHMTCAKCNHSFCWRCLK 1592          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Yeast
Match: ITT1 (Protein that modulates the efficiency of translation termination; interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins [Source:SGD;Acc:S000004533])

HSP 1 Score: 74.3294 bits (181), Expect = 7.820e-15
Identity = 87/381 (22.83%), Postives = 144/381 (37.80%), Query Frame = 2
Query:  311 LLDISLLCIWLSDDLLETVRIKVISLLKESGD----------GVLWKCFQFLENETLTFLFGTHSNEFVLDIHRMIDETNGKLLYESLKDYNNRMNESTFNNSIFDCSVCTIAKRGINCV----EFTKCKHVFCLACAHDYYDIQIKNGNLK-FECMICGQDIENLE---------------------IRKVMTKEEFERWDKLILNQCLKEEKSF-----YNCPRCEMTVLVEGEEFGI--CPKCFFVFCIRCKMMYRGSCICNSVVKMISIFGCLIN--------------------CTNVYNIKFSNYLEK---EEKVNAELENYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHFGLA-PNCY 1252
            ++DI  L  W+S D  + +  K + L++E+ D           +L   F FL ++T   LF          I + + +      Y+  K  +        + S + C +C   ++G+  +    E    +H  C  CA  Y+   I+   +    C  C      LE                     +++V+  E  ER++K+  NQ       +       C RC+     E  +  +  C KC FVFC  C   + G    N   K +S+   +I                        V  ++ ++YL +   +  +  E  N + CP CK   E+ +GCNKM C  C   FC++C  +L    PY+HF  A   CY
Sbjct:   87 VMDIKSL--WISTDEKKMLIDKALRLVEETVDMSIEFADSFTSILILIFGFLIDDTAILLFPN-------GIRKCLTQDQ----YDLFKQISEEATLQKVSRSNYHCCICMEMEKGVRMIKLPCENANVEHYLCRGCAKSYFTAMIQENRISSVRCPQCEYKELKLEDFKSYKKMLKALFTPLIPVSFLKEVIDTELCERYEKMFYNQAATRLSKYCPYACVTCRRCDSWCTKEDLDDAMIQCQKCHFVFCFDCLHAWHG--YNNKCGKKVSLSTDIIEEYLDDTVTSYERKRKLEAKYGRRVLELEVNDYLAEKMLDLAIKKEGSNLQRCPKCKVVVERSEGCNKMKCEVCGTLFCFICGVLLYPEDPYEHFREAYSGCY 452          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Yeast
Match: HEL1 (RING finger ubiquitin ligase (E3); involved in ubiquitination and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU) [Source:SGD;Acc:S000001725])

HSP 1 Score: 67.3958 bits (163), Expect = 1.418e-12
Identity = 59/228 (25.88%), Postives = 93/228 (40.79%), Query Frame = 2
Query:  548 DYNNRMNESTFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFECMICGQDIENLEIRKVMTKEEFER-WDKLILNQCLKEEKSFYNCPRCEMTVLVEGEEFGICPKCFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVYNIKFSNYLEKEEKVNAELENY-----KSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKH 1213
            DYN+   E  F N  F C +C   K         +C H +C+ C   Y   ++  GN+   CM C   ++N +I KVM      +  D  I +   K  +++  CP  +   +V   +    P+         ++ Y     CNS  +    F C     +  + K +    K+ +  +E+ N+     K CP C    EK  GCN M CS C+  FC++C      H
Sbjct:  163 DYNSHFREVEFKND-FTCIICCDKKDTETFA--LECGHEYCINCYRHYIKDKLHEGNI-ITCMDCSLALKNEDIDKVMGHPSSSKLMDSSIKSFVQKHNRNYKWCPFADCKSIVHLRDTSSLPE-------YTRLHYSPFVKCNSFHRFC--FNCGFEVHSPADCKITTAWVKKARKESEILNWVLSHTKECPKCSVNIEKNGGCNHMVCSSCKYEFCWICEGPWAPH 377          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Nematostella
Match: EDO47022 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RN84])

HSP 1 Score: 145.206 bits (365), Expect = 1.124e-38
Identity = 110/384 (28.65%), Postives = 167/384 (43.49%), Query Frame = 2
Query:  245 EFFKINFFPPISINLSF-DKYSEL--LDISLLCIWLSDDLLETV--RIKVISLLKESGDGVLWKCFQFLENETLTFL-------FGTHSNEFV------LDIHRMIDETNGKLLYESLKDYNNRMNESTFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLK-FECMI--CGQDIENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPR--CEMTVLVEGEE-FGICPKCFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVYNIKFSNYLEKEEKVNAELE-----------------------NYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHFG-LAPNCY 1252
            E   + + PPI +N    + Y  +   + +L C WL+   L  +   +  I   +  GD ++++  QFL +E L  L          H  + +      +D   + D  +  LL  S+ +Y  +     F+ S F C VC   K G  C+ F  C HVFC  C   Y+ +QI +G++K   C    C       ++++V+++E F ++DK +L   L        CPR  C+  VLV+ E   G+CP C F FC  C++ Y G            +  C I  +    ++ + YL+  E+  A L+                       N   CP C    +K DGCNKMTC  CR  FC+LCR IL    PY HF  L   C+
Sbjct:   62 ECIDLKYLPPIVLNFVMPENYPSIQPPEYTLSCKWLTRQQLSKLCKDLDEIWTDQGVGDVIIFRWTQFLMDEALEVLNIKSPMTVRFHRQQSIPLDSSLVDKRAVQDVASYSLLIASILEYEKQEKARVFDTSYFTCDVCFSEKPGSMCLAFHNCGHVFCCECMTGYFTVQINDGSVKALTCPTSKCESQALPSQVKRVVSEETFAKYDKFLLQSSLDGMSDITYCPRPDCQSPVLVDSESTIGLCPACSFAFCKICRLGYHG------------VSPCSIKNSEFRKLR-TEYLKATEEERALLDQRYGRDRLKKVFEEVVSEDWVKSNCTKCPSCSYQIQKFDGCNKMTCIKCRANFCWLCRSILLTTNPYLHFNKLGSQCF 432          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Nematostella
Match: EDO48096 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RK36])

HSP 1 Score: 62.7734 bits (151), Expect = 1.082e-10
Identity = 52/193 (26.94%), Postives = 73/193 (37.82%), Query Frame = 2
Query:  653 CKHVFCLACAHDYYDIQIKNG-NLKFECMICGQDIENLEIRKVMTKEEF-ERWDKLILNQCLKEEKSFYNCPRCEMTVLVEGEEFG----ICPKCFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVYNIKFSNYLEKEEKVNAELENYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKH 1213
            C H FC +C   ++  Q++ G +   ECM C   +    +  V+   +  E++   + N  +K       CP      LV  EE      IC KC  +FC  C   Y     C ++ K       L  C            +  E  N    N K CP C    EK  GCN M C  C+  FC++C      H
Sbjct:  137 CGHFFCDSCWSAHFASQLQIGVSSGIECMNCNLLVGETVVLNVLKGGKLREKFINFLFNDQIKTFSKLRWCPGINCGFLVRAEEPAAKRVICSKCNTMFCFSCGEKYHAPTDCATIRKW------LTKCE-----------DDSETANYITANTKDCPECGSCIEKNGGCNHMQCIKCKHDFCWMCMGTWKSH 312          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Nematostella
Match: EDO47093 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RN86])

HSP 1 Score: 63.1586 bits (152), Expect = 1.224e-10
Identity = 64/244 (26.23%), Postives = 96/244 (39.34%), Query Frame = 2
Query:  506 IDETNGKLLYESLKDYNNRMNESTFNNSIF--DCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFECMI--CGQDIENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPRCEMTVLVEGEE-------FGICPKCFFVFCIRCKMMYRGSCICNSVVKMISIFG----CLINCTNVYNIKFSNYLEKEEKVNAELENYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLC 1192
            + E N KL  + +K    R    T +  +   +C +C    R         C H FC  C   Y   QI  G     C    C   ++N+ I   +T   + ++ K  LN+ L+   S+  CP      +V G E       + +  KC  ++C +C         C    K   I G     LIN             E++E +N+ +   K+CP C    EK  GCN MTC  C+  FC++C
Sbjct:  513 VSEANEKLQQDLVKQAKIRSGIDTRDWFMVSKECGICFGDFRENKMTALMSCGHSFCTECWEFYLKSQISRGEGDIGCPGYNCDVTLDNVTIMS-LTPSWYPKFLKRKLNRALEMTSSWRWCPGKNCRQVVNGTELSPNSSAWSVLCKCGGIWCFKCGSQAHWPASCVEARKFYRIAGNYEKLLIN-------------ERKELINSVM--VKNCPSCHYPIEKHLGCNFMTCVMCKTNFCWIC 740          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Nematostella
Match: EDO37844 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SEN1])

HSP 1 Score: 55.4546 bits (132), Expect = 3.683e-8
Identity = 46/199 (23.12%), Postives = 84/199 (42.21%), Query Frame = 2
Query:  653 CKHVFCLACAHDYYDIQIKNGNLKFEC--MICGQDIENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPRCEM-------TVLVEGEEFGICP--KCFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVYNIKFSNYLEKEEKVNAELENY-KSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKH 1213
            C H FC +C H Y  +QI++G+   +C   +C   I++  +  ++  E  E++ +  +N  L   + +  C +C         T +    E  +    +C   +C RCK        C+   +              + +K+++ L + ++ +     Y K CP C+   EK  GC  M C  C+  FC+ C  +  KH
Sbjct:  549 CSHKFCNSCWHQYLTVQIRSGHSPLKCPGHMCDAIIDDTTVMSLVP-ELLEQFIRNKVNMKLCSGQQWQQCEKCAFYVKLVLPTCIANSTEVPVHVVCRCGNTWCSRCKDEPHWPASCSQAER--------------FWLKYADQLSEYQRKDLFYSVYIKRCPHCRYPIEKNGGCPHMYCILCKATFCWHCLTLFSKH 732          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Nematostella
Match: EDO37437 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFQ2])

HSP 1 Score: 51.6026 bits (122), Expect = 2.377e-7
Identity = 51/206 (24.76%), Postives = 84/206 (40.78%), Query Frame = 2
Query:  653 CKHVFCLACAHDYYDIQIKNGN-LKFECM--ICGQ--DIENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPRCEMTVLVEGEEFGI----CPKCFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVYNIKFSNYLEKEEKVNAELENYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHFGLAP 1243
            C   FC  C   Y    I +G+ L+  C   +C    D+   EI  ++ ++ F+ + K+   + ++  KS   CP+ +   +VE          C +C + FC  CK  +     C +                   IKF   +  EE     L   K+CP C+   ++ +GC +M C  C+  FC+ C K LD     +H+   P
Sbjct:   42 CGCFFCKECLKQYVAHAIADGSVLQIPCPDGVCPDKGDLMESEIADLIAEDLFQNFQKMRAIKEIQISKSKAFCPKPDCKGVVESIPGAAKEVCCSECGYSFCFACKGPWHPEKHCQN------------KGEKANGIKFFELVNGEE----VLVEIKACPTCQVLIQRDEGCAQMMCGNCKHIFCWHCLKGLDSDILLRHYDKGP 231          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Medaka
Match: zmp:0000000524 (ring finger protein 14 [Source:NCBI gene;Acc:101167638])

HSP 1 Score: 144.821 bits (364), Expect = 5.553e-38
Identity = 117/450 (26.00%), Postives = 197/450 (43.78%), Query Frame = 2
Query:  107 EELEALVEIYTNLNYKLTEFYESLTIFFSADIKLNEFKELQIQNNQEF-FKINFFPPISINLSFDKYSELLDISLLCI---WLSDDLLETVRIKVISLLKES-GDGVLWKCFQFLENETLTFL------------------------------------------------FGTHSNEFVLDIHRMIDETNGKLLYESLKDYNNRMNESTFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFECMICGQD-----IENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPR--CEMTVLVEGE-EFGICPKCFFVFCIRCKMMYRGSCICN-SVVKMISIFGCLINCTNVYNIKFSNYLEK-----------EEKVNAE--LENYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHF 1231
            +EL AL  IY    +   E  +   I    ++   +FK + ++  Q   + + F PP+ +N         L   +  +   W++   L T+  ++  L +E+ G  +L+   QFL+ ETL FL                                                 G H ++       ++D     L    L D++    +  F++ +F C +C   K G +C+ F +C+HV+C AC  +Y+ IQI++GN+  +C+ C +         L++++++ +E F R+D+L+L   L        CPR  C   V+VE +   GIC  C   FC  CK+ Y G   C     ++ ++    ++ T+    +   ++EK           EE  + +   EN K CP C    +K+DGCNKMTC+ C+ YFC+LC  +L K  PY HF
Sbjct:   10 DELLALASIYDEEEFHQAESAQGGEIQICLELP-PDFKVVVVKGEQTTEYAVCFLPPLVLNFELPGDYPSLSAPVFTLSSKWMTKAQLSTLCQRLDELWEENQGCVILFTWMQFLKEETLDFLGIKSPLEVNRNNTKLCGERRKTDPTAADVTKCDSKSEVAENKPEITDKLGQHPSKLDPRAVVLMDPRADPL--PQLLDFDEAQRQKVFDSKVFCCGICFSEKLGSHCLCFKECQHVYCNACMTEYFQIQIRDGNV--QCLNCPEPKCTSLATPLQVKQLVDEELFARYDRLLLQSTLDLMADVVYCPRQFCGTAVMVEPDTTMGICSACQHAFCTMCKLAYHGVSHCKFPAEELRNLRDEYLSATS----EGKKFMEKRFGKRVIQKAVEESFSRDWLTENCKCCPKCGTNIQKVDGCNKMTCTSCKQYFCWLCLGVLSKVNPYGHF 450          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Medaka
Match: ENSORLT00000014493.2 (E3 ubiquitin-protein ligase RNF14 [Source:NCBI gene;Acc:101172569])

HSP 1 Score: 97.0561 bits (240), Expect = 3.282e-21
Identity = 69/266 (25.94%), Postives = 107/266 (40.23%), Query Frame = 2
Query:  515 TNGKLLYESLKDYNNRMNESTFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLK-FECMICG--QDIENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPR--CEMTVLVE-GEEFGICPKCFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVYNIKFSNYLEKEEKVNAELENYKS------------------------------------CPGCKQAFEKIDGCNKMTCSYCRIYFCY 1186
            T+ ++L   +  +N    E  F  ++FDC +C  A  G +CV+   C HVFC  C  ++  +QI  GN++   C   G        +++ V+ +E F  +D+L+L   L        CPR  C   +L+E      +C +C F FC  CK  Y G+  C    K+    G     +           + EE + A LE+YKS                                    CP C    EK  GC+ M C++C  +F +
Sbjct:  326 TSSQILLSQILIHNASQKEKVFRTTVFDCGICFTALLGSDCVQIHGCGHVFCQTCLREFCKVQITEGNVQGVTCPQAGCPAAPTPAQVKTVVGEELFSHYDRLLLQFTLDRMSDVIYCPRPSCSSVILLEKSSNVALCSECHFAFCTTCKKNYHGASKCYEEKKIQEESGTTPELS---------MPQSEEGIKALLEDYKSGSKERRRLLDRRYGSAILASLEDNLNEMWKIDNTQPCPHCYIPIEKNGGCSHMWCTHCNNFFVW 582          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Medaka
Match: si:ch211-278j3.3 (E3 ubiquitin-protein ligase RNF19A [Source:NCBI gene;Acc:101162972])

HSP 1 Score: 69.707 bits (169), Expect = 2.354e-12
Identity = 56/251 (22.31%), Postives = 100/251 (39.84%), Query Frame = 2
Query:  494 IHRMIDETNGKLLYESLKDYNNRMNESTFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFECMICGQDIENLEIRKVMTKEEF-ERWDKLILNQCLKEEKSFYNCPRCEMTVLVEGEEFGICPK-------CFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVYNIKFSNYLEKEEKVNAELENYKSCPGCKQAFEKI-DG-CNKMTCSYCRIYFCYLC-RKILDKH 1213
            + R+  E+ G L   S         +   +  + +C +C +++   +    + C H  C  C   Y  I+I    +   C  C + +  L++R ++      ER+++  L + L  +     CP  + +  V       CPK       C   FC  C+ ++  +  C+   +  +      N   +Y           E+   + E  K+CP C     K  DG CN+M C+ C   FC+LC ++I D H
Sbjct:   93 VGRVSSESTGVLSLSSCS------QDKLLDEHLEECPLCLLSQPRCHFPRLSSCSHRACSDCLRQYLRIEISESRVGIACPQCPETLAPLDVRAILDDSALLERFEEYQLRRFLAADPDTRWCPAPDCSYAVIAYGCAECPKLSCGREGCDTEFCYHCRQLWHPNQTCDQARRQRARHTSGSNDPTLYVFN--------EEAGGDAEEIKACPRCGAYIMKTNDGSCNRMNCTVCACQFCWLCMQEITDVH 329          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Medaka
Match: ENSORLT00000035803.1 (ring finger protein 19B [Source:NCBI gene;Acc:101169466])

HSP 1 Score: 68.9366 bits (167), Expect = 4.751e-12
Identity = 54/223 (24.22%), Postives = 92/223 (41.26%), Query Frame = 2
Query:  584 NSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFECMICGQDIENLEIRKVMTKEE-FERWDKLILNQCLKEEKSFYNCPR--CEMTVLVEGEEFGICPK-------CFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVYNIKFSNYLEKEEKVNAELENYKSCPGCKQAFEKI-DG-CNKMTCSYCRIYFCYLCRK-ILDKH 1213
            +++ +C +C +        E   C H  CL C   Y  I+I    ++  C  C + +   ++  ++      E++++ +L +CL  +     CP   C   V+  G     CP+       C   FC  CK  +  +  C+S  +            +++    SN+     +     ++ K CP C     K+ DG CN MTC+ C   FC+LC K I D H
Sbjct:  123 SNLLECPLCLVRLPPEQLPELLGCSHRSCLCCLRQYLRIEITESRVQLSCPECAERLAPRQVADILDDTALLEKYEEFLLRRCLASDPDCRWCPAPDCGFAVIASG--CASCPRLVCRREGCGAEFCYHCKQAWHPNQTCDSARQQ--------RAQSLHT--HSNHSPSFTQEQGPADDIKPCPRCGAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLH 333          
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Medaka
Match: arih2 (ariadne RBR E3 ubiquitin protein ligase 2 [Source:NCBI gene;Acc:101159099])

HSP 1 Score: 63.929 bits (154), Expect = 1.318e-10
Identity = 47/190 (24.74%), Postives = 84/190 (44.21%), Query Frame = 2
Query:  653 CKHVFCLACAHDYYDIQIKNG-NLKFECMICGQD-----IENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPRCEMTVLVEGEEFGI----CPKCFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVYNIKFSNYLEKEEKVNAELENYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLC 1192
            C+H FC AC   +  + +K+G  +   CM   QD      E+  +  +  +E  +++ + +    ++       CP  +  ++++ +E       C +C  VFC +C+ MY     C ++ K       L  C +  + + +NY+           + K CP C    EK  GCN M CS C+  FC++C
Sbjct:  158 CQHYFCTACWEQHCTVLVKDGTGVGISCM--AQDCPLRMPEDFVLPLLQGEELKDKYRRYLFRDYIESHFRLQLCPGADCPIVIKVQEPRARRVQCSRCGEVFCFKCRQMYHAPTDCATIRKW------LTKCAD--DSETANYISA---------HTKDCPKCNICIEKNGGCNHMQCSKCKHDFCWMC 328          
BLAST of RBR-type E3 ubiquitin transferase vs. Planmine SMEST
Match: SMESG000081048.1 (SMESG000081048.1)

HSP 1 Score: 301.597 bits (771), Expect = 2.669e-102
Identity = 151/173 (87.28%), Postives = 152/173 (87.86%), Query Frame = 2
Query:  734 MICGQDIENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPRCEMTVLVEGEEFGICPKCFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVYNIKFSNYLEKEEKVNAELENYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHFGLAPNCY 1252
            MICGQDIENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPRCEMTVLVEGEEFGICPKCFFVFCIRCKMMYRGSCICNSVVKMI                     +KEEKVNAELENYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHFGLAPNCY
Sbjct:    1 MICGQDIENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPRCEMTVLVEGEEFGICPKCFFVFCIRCKMMYRGSCICNSVVKMI---------------------KKEEKVNAELENYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHRPYQHFGLAPNCY 152          
BLAST of RBR-type E3 ubiquitin transferase vs. Planmine SMEST
Match: SMESG000061950.1 (SMESG000061950.1)

HSP 1 Score: 62.7734 bits (151), Expect = 1.720e-10
Identity = 54/212 (25.47%), Postives = 96/212 (45.28%), Query Frame = 2
Query:  572 STFNNSIFDCSVC-TIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFECMI--CGQDIENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNC--PRCE-MTVLVEGEEFGICPKCFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVYNIKFSNYLEKEEKVNAELENYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYL 1189
            S  N+ +F C  C  I  +G   V+   C H+FC  C     +    +  +  +C+   C  +I++ EIRK++ + ++E + +  +N  + + K+ ++C  P C+   +  EG +   CP C  + CI C ++++ S  C                 N  +     Y+E + K       Y  CP C    EKI GCN + CS C++  C++
Sbjct:  155 SLPNDEVFTCLTCLKIIPKGSG-VKLMNCYHMFCRDCLKGSIN---SSQIIPVKCLSAECNWEIQDREIRKILNERDYEIYHEKCMNLAISKMKNNFHCKTPNCKYFCIYDEGLKNFTCPICHSLNCINCNVVHKNSETCKQYQDGYP---------NTIDKHTVKYIEDQIKKGK----YMKCPACNCLLEKISGCNWVQCSNCKLELCWI 349          
BLAST of RBR-type E3 ubiquitin transferase vs. Planmine SMEST
Match: SMESG000013684.1 (SMESG000013684.1)

HSP 1 Score: 55.0694 bits (131), Expect = 6.829e-8
Identity = 47/212 (22.17%), Postives = 89/212 (41.98%), Query Frame = 2
Query:  575 TFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFECMICGQDIENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPRCEMTVLVEGEEFGI-----CPKCFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVYNIKFSNYLEKEEKVNAELENYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCR 1195
            TF + +  C +C +     + +    C H  C  C ++Y  I + +  ++     C   +E+ EIR ++   ++ ++ +L L     +EK  Y+C     T  +  +  GI     CP+C    CI C+ ++ G   C    K+ +    +    +++       +E  E +         CPGC    +K  GC+ +TC  C I  C+  +
Sbjct:  295 TFTSEVTVCPICLVDYDPGDAIVLHSCLHTICKECLNNYL-INVNDAQVRCPTTNCIGLVEDQEIRAILNDSDYIKYQELGLRMAEAKEKFSYHCKEVNCTAWITYD--GIVRSYNCPRCKKENCIVCQGIHEGM-TCEEYQKVKANERQMNPADDLF---IKKMIESGEAM--------KCPGCGILVQKNRGCDGVTCRSCGIMMCWATK 491          
BLAST of RBR-type E3 ubiquitin transferase vs. Planmine SMEST
Match: SMESG000013684.1 (SMESG000013684.1)

HSP 1 Score: 55.0694 bits (131), Expect = 7.147e-8
Identity = 47/212 (22.17%), Postives = 89/212 (41.98%), Query Frame = 2
Query:  575 TFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFECMICGQDIENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPRCEMTVLVEGEEFGI-----CPKCFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVYNIKFSNYLEKEEKVNAELENYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCR 1195
            TF + +  C +C +     + +    C H  C  C ++Y  I + +  ++     C   +E+ EIR ++   ++ ++ +L L     +EK  Y+C     T  +  +  GI     CP+C    CI C+ ++ G   C    K+ +    +    +++       +E  E +         CPGC    +K  GC+ +TC  C I  C+  +
Sbjct:  282 TFTSEVTVCPICLVDYDPGDAIVLHSCLHTICKECLNNYL-INVNDAQVRCPTTNCIGLVEDQEIRAILNDSDYIKYQELGLRMAEAKEKFSYHCKEVNCTAWITYD--GIVRSYNCPRCKKENCIVCQGIHEGM-TCEEYQKVKANERQMNPADDLF---IKKMIESGEAM--------KCPGCGILVQKNRGCDGVTCRSCGIMMCWATK 478          
BLAST of RBR-type E3 ubiquitin transferase vs. Planmine SMEST
Match: SMESG000069298.1 (SMESG000069298.1)

HSP 1 Score: 54.299 bits (129), Expect = 1.124e-7
Identity = 52/217 (23.96%), Postives = 88/217 (40.55%), Query Frame = 2
Query:  578 FNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDYYDIQIKNGNLKFECMICGQDIENLEIRKVMTKEEFERWDKLILNQCLKEEKSFYNCPRCEMTVLVEGEEFGI----CPKCFFVFCIRCKMMYRGSCICNSVVKMISIFGCLINCTNVYNIKFSNYLEKEEKVNAELENYKSCPGCKQAFEKIDGCNKMTCSYCRIYFCYLCRKILDKHR 1216
             NN IF+C  C         V+   C H+ C  C  +Y    I     K     C   IE+ EI+ +++  E+E +++ ++N    + ++ Y C   + T + E  +  +    CP C  V C+ C  +++    C    K I         +  +        E+ +K    +     CP C    +K+ GCN + CS C +  C+    IL  HR
Sbjct:  176 MNNEIFECFSCYTCIAKGQGVKLRNCYHLVCKTCLENYLKT-ISKIPPKCPHAYCKLTIEDREIKAILSGNEYEIYNQKLINSIKSKLENRYQCQTPDCTYICEIIDVKMKTLKCPNCKMVNCLLCHAVHKNE-TCAKFRKRID--------STAFGATQRAIEERIKKGECMM-----CPDCNSLIQKVRGCNWIQCSSCGVELCW----ILQMHR 373          
The following BLAST results are available for this feature:
BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
RNF141.258e-3927.79ring finger protein 14 [Source:HGNC Symbol;Acc:HGN... [more]
RNF141.258e-3927.79ring finger protein 14 [Source:HGNC Symbol;Acc:HGN... [more]
RNF141.258e-3927.79ring finger protein 14 [Source:HGNC Symbol;Acc:HGN... [more]
RNF141.258e-3927.79ring finger protein 14 [Source:HGNC Symbol;Acc:HGN... [more]
RNF146.066e-3730.77ring finger protein 14 [Source:HGNC Symbol;Acc:HGN... [more]
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BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
F56D2.57.934e-2324.18RBR-type E3 ubiquitin transferase [Source:UniProt... [more]
F56D2.23.490e-1825.07RBR-type E3 ubiquitin transferase [Source:UniProt... [more]
C17H11.61.168e-921.69RBR-type E3 ubiquitin transferase [Source:UniProt... [more]
C17H11.61.168e-921.69RBR-type E3 ubiquitin transferase [Source:UniProt... [more]
C17H11.61.773e-922.22RBR-type E3 ubiquitin transferase [Source:UniProt... [more]
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BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ari-22.539e-1026.21gene:FBgn0025186 transcript:FBtr0071774[more]
CG331449.827e-921.85gene:FBgn0053144 transcript:FBtr0302517[more]
CG331449.827e-921.85gene:FBgn0053144 transcript:FBtr0088254[more]
LUBEL7.798e-822.47gene:FBgn0031857 transcript:FBtr0331221[more]
LUBEL7.807e-822.47gene:FBgn0031857 transcript:FBtr0331220[more]
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BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CABZ01061592.13.257e-4129.48E3 ubiquitin-protein ligase RNF14-like [Source:NCB... [more]
rnf141.189e-3928.81ring finger protein 14 [Source:ZFIN;Acc:ZDB-GENE-0... [more]
rnf141.189e-3928.81ring finger protein 14 [Source:ZFIN;Acc:ZDB-GENE-0... [more]
zmp:00000005244.177e-3930.17zmp:0000000524 [Source:ZFIN;Acc:ZDB-GENE-130530-52... [more]
zmp:00000005241.567e-3829.69zmp:0000000524 [Source:ZFIN;Acc:ZDB-GENE-130530-52... [more]
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BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSXETT00000012882.11.263e-4327.55ring finger protein 14 gene 4 [Source:NCBI gene;Ac... [more]
ENSXETT00000028050.13.474e-4028.40pep primary_assembly:Xenopus_tropicalis_v9.1:KV460... [more]
gpr1568.256e-4028.24G protein-coupled receptor 156 [Source:Xenbase;Acc... [more]
znf3478.377e-3927.97zinc finger protein 347 [Source:Xenbase;Acc:XB-GEN... [more]
ENSXETT00000035372.11.469e-3627.74E3 ubiquitin-protein ligase RNF14-like [Source:NCB... [more]
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BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Rnf141.458e-4128.48ring finger protein 14 [Source:MGI Symbol;Acc:MGI:... [more]
Rnf141.458e-4128.48ring finger protein 14 [Source:MGI Symbol;Acc:MGI:... [more]
Rnf141.458e-4128.48ring finger protein 14 [Source:MGI Symbol;Acc:MGI:... [more]
Rnf142.928e-3832.61ring finger protein 14 [Source:MGI Symbol;Acc:MGI:... [more]
Arih26.311e-1123.77ariadne RBR E3 ubiquitin protein ligase 2 [Source:... [more]
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BLAST of RBR-type E3 ubiquitin transferase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q9JI90|RNF14_MOUSE1.020e-4028.48E3 ubiquitin-protein ligase RNF14 OS=Mus musculus ... [more]
sp|Q9UBS8|RNF14_HUMAN6.042e-3927.79E3 ubiquitin-protein ligase RNF14 OS=Homo sapiens ... [more]
sp|Q9US46|ITT1_SCHPO1.032e-1726.88E3 ubiquitin-protein ligase itt1 OS=Schizosaccharo... [more]
sp|Q04638|ITT1_YEAST5.430e-1322.83Translation termination inhibitor protein ITT1 OS=... [more]
sp|Q9SKC3|ARI9_ARATH8.176e-1228.22Probable E3 ubiquitin-protein ligase ARI9 OS=Arabi... [more]
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BLAST of RBR-type E3 ubiquitin transferase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A401P3274.125e-4628.51RBR-type E3 ubiquitin transferase OS=Scyliorhinus ... [more]
Q1RL494.285e-4329.52RBR-type E3 ubiquitin transferase OS=Ciona intesti... [more]
R4GDE83.770e-4229.77RBR-type E3 ubiquitin transferase OS=Anolis caroli... [more]
G1KNM74.617e-4229.77RBR-type E3 ubiquitin transferase OS=Anolis caroli... [more]
A0A3Q0K3F85.259e-4128.80RBR-type E3 ubiquitin transferase OS=Ciona intesti... [more]
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BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
zmp:00000005247.090e-4327.59ring finger protein 14 [Source:NCBI gene;Acc:10304... [more]
rnf19b6.249e-1323.79ring finger protein 19B [Source:NCBI gene;Acc:1030... [more]
si:ch211-278j3.34.537e-1223.29E3 ubiquitin-protein ligase RNF19B-like [Source:NC... [more]
arih21.181e-1024.47ariadne RBR E3 ubiquitin protein ligase 2 [Source:... [more]
rnf2171.790e-721.74ring finger protein 217 [Source:NCBI gene;Acc:1030... [more]
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BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 4
Match NameE-valueIdentityDescription
zmp:00000005246.203e-3928.46zmp:0000000524 [Source:ZFIN;Acc:ZDB-GENE-130530-52... [more]
rnf19a2.510e-1124.55ring finger protein 19A, RBR E3 ubiquitin protein ... [more]
ankib1a8.270e-723.94ankyrin repeat and IBR domain containing 1a [Sourc... [more]
ENSPMAT00000007741.11.615e-624.53pep scaffold:Pmarinus_7.0:GL477427:676:25209:1 gen... [more]
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BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 2
Match NameE-valueIdentityDescription
ITT17.820e-1522.83Protein that modulates the efficiency of translati... [more]
HEL11.418e-1225.88RING finger ubiquitin ligase (E3); involved in ubi... [more]
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BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO470221.124e-3828.65Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO480961.082e-1026.94Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO470931.224e-1026.23Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO378443.683e-823.12Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO374372.377e-724.76Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of RBR-type E3 ubiquitin transferase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
zmp:00000005245.553e-3826.00ring finger protein 14 [Source:NCBI gene;Acc:10116... [more]
ENSORLT00000014493.23.282e-2125.94E3 ubiquitin-protein ligase RNF14 [Source:NCBI gen... [more]
si:ch211-278j3.32.354e-1222.31E3 ubiquitin-protein ligase RNF19A [Source:NCBI ge... [more]
ENSORLT00000035803.14.751e-1224.22ring finger protein 19B [Source:NCBI gene;Acc:1011... [more]
arih21.318e-1024.74ariadne RBR E3 ubiquitin protein ligase 2 [Source:... [more]
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BLAST of RBR-type E3 ubiquitin transferase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000081048.12.669e-10287.28SMESG000081048.1[more]
SMESG000061950.11.720e-1025.47SMESG000061950.1[more]
SMESG000013684.16.829e-822.17SMESG000013684.1[more]
SMESG000013684.17.147e-822.17SMESG000013684.1[more]
SMESG000069298.11.124e-723.96SMESG000069298.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30031537 ID=SMED30031537|Name=RBR-type E3 ubiquitin transferase|organism=Schmidtea mediterranea sexual|type=transcript|length=1341bp
TATTTAAAATATTTGTTAACGTGTTTTAAAATATCATTTCTATAAATTAA
TTTTTTGTTAATTTAAAATTTTTGTGAATAATTTAGCATTTATGAAAAAA
ATTTTAGAAGAATTAGAAGCATTAGTGGAAATTTATACAAACTTGAATTA
CAAATTAACTGAATTTTATGAATCATTAACTATTTTTTTTAGTGCAGACA
TAAAACTTAACGAATTTAAAGAACTGCAAATTCAAAATAATCAAGAATTC
TTTAAAATTAACTTTTTTCCTCCAATATCAATCAATTTATCTTTTGACAA
GTATTCAGAACTTTTGGATATATCATTATTATGCATTTGGTTGTCTGATG
ATCTTTTAGAAACAGTCCGTATAAAAGTTATCTCATTGTTAAAAGAATCA
GGGGATGGAGTTTTGTGGAAATGTTTTCAGTTTTTAGAAAATGAAACTTT
AACATTTCTTTTTGGTACACATTCCAATGAATTTGTATTGGACATCCATC
GGATGATAGATGAAACAAATGGAAAATTGTTGTATGAATCTTTAAAAGAT
TATAATAATCGAATGAATGAAAGCACTTTTAATAATTCAATTTTTGATTG
TTCAGTTTGCACGATAGCTAAAAGAGGGATTAATTGTGTAGAATTCACCA
AATGCAAACACGTCTTTTGTCTAGCCTGTGCACATGATTACTATGATATC
CAAATTAAAAATGGAAATTTAAAATTTGAATGCATGATTTGTGGTCAAGA
TATTGAAAATTTAGAAATTAGAAAAGTAATGACAAAAGAAGAGTTCGAAC
GGTGGGATAAATTAATATTGAATCAATGTTTAAAGGAAGAAAAATCATTT
TACAATTGTCCCCGTTGTGAAATGACTGTTCTGGTAGAAGGTGAAGAATT
TGGAATTTGCCCAAAATGCTTTTTTGTGTTTTGCATCCGTTGCAAGATGA
TGTATCGTGGATCATGTATCTGTAATAGTGTAGTGAAGATGATAAGTATT
TTTGGATGTTTAATAAATTGCACAAATGTTTATAATATAAAATTTTCAAA
CTATTTAGAAAAAGAAGAAAAGGTGAATGCTGAATTGGAAAATTATAAAT
CATGTCCCGGATGTAAACAGGCATTTGAAAAAATTGACGGGTGCAATAAA
ATGACTTGCTCATATTGTCGAATCTATTTCTGTTATCTGTGCAGGAAAAT
CTTGGATAAACATCGGCCTTATCAGCATTTCGGGTTGGCCCCGAATTGTT
ATTTGTAGTGATCGAGATTTTCAGCTTCATTAAGTCTTAGCAAAGGCAAT
TGGTGGAAAATTTTTATTTATAAAAGTTTGATAAATGGTGA
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protein sequence of SMED30031537-orf-1

>SMED30031537-orf-1 ID=SMED30031537-orf-1|Name=SMED30031537-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=389bp
MKKILEELEALVEIYTNLNYKLTEFYESLTIFFSADIKLNEFKELQIQNN
QEFFKINFFPPISINLSFDKYSELLDISLLCIWLSDDLLETVRIKVISLL
KESGDGVLWKCFQFLENETLTFLFGTHSNEFVLDIHRMIDETNGKLLYES
LKDYNNRMNESTFNNSIFDCSVCTIAKRGINCVEFTKCKHVFCLACAHDY
YDIQIKNGNLKFECMICGQDIENLEIRKVMTKEEFERWDKLILNQCLKEE
KSFYNCPRCEMTVLVEGEEFGICPKCFFVFCIRCKMMYRGSCICNSVVKM
ISIFGCLINCTNVYNIKFSNYLEKEEKVNAELENYKSCPGCKQAFEKIDG
CNKMTCSYCRIYFCYLCRKILDKHRPYQHFGLAPNCYL*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0016740transferase activity
GO:0005515protein binding
GO:0008270zinc ion binding
GO:0004842ubiquitin-protein transferase activity
GO:0016874ligase activity
GO:0046872metal ion binding
Vocabulary: INTERPRO
TermDefinition
IPR031127E3_UB_ligase_RBR
IPR002867IBR_dom
IPR013083Znf_RING/FYVE/PHD
IPR017907Znf_RING_CS
IPR001841Znf_RING
Vocabulary: biological process
TermDefinition
GO:0016567protein ubiquitination
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR002867IBR domainSMARTSM00647ibrneu5coord: 102..172
e-value: 0.11
score: 12.5
coord: 22..80
e-value: 0.0013
score: 28.0
IPR002867IBR domainPFAMPF01485IBRcoord: 22..80
e-value: 1.5E-5
score: 25.1
coord: 109..157
e-value: 1.9E-8
score: 34.4
NoneNo IPR availableGENE3DG3DSA:1.20.120.1750coord: 94..170
e-value: 2.9E-14
score: 55.4
NoneNo IPR availablePANTHERPTHR11685:SF221E3 UBIQUITIN-PROTEIN LIGASE RNF14coord: 3..166
NoneNo IPR availablePROSITEPS51873TRIADcoord: 1..174
score: 18.282
NoneNo IPR availableSUPERFAMILYSSF57850RING/U-boxcoord: 113..166
NoneNo IPR availableSUPERFAMILYSSF57850RING/U-boxcoord: 22..84
IPR031127E3 ubiquitin ligase RBR familyPANTHERPTHR11685RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAININGcoord: 3..166