Neuronal guanine nucleotide exchange factor

Overview


Name	Neuronal guanine nucleotide exchange factor
Smed ID	SMED30031446
Length (bp)	2017

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Neuronal guanine nucleotide exchange factor (SMED30031446) t-SNE clustered cells

Violin plots show distribution of expression levels for Neuronal guanine nucleotide exchange factor (SMED30031446) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Neuronal guanine nucleotide exchange factor (SMED30031446) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30031446

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 6

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
pharynx	SMED30031446	SMESG000003812.1	dd_Smed_v4_5524_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
protonephridia	SMED30031446	SMESG000003812.1	dd_Smed_v4_5524_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
gut	SMED30031446	SMESG000003812.1	dd_Smed_v4_5524_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30031446	SMESG000003812.1	dd_Smed_v4_5524_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30031446	SMESG000003812.1	dd_Smed_v4_5524_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30031446	SMESG000003812.1	dd_Smed_v4_5524_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Human
Match: NGEF (neuronal guanine nucleotide exchange factor [Source:HGNC Symbol;Acc:HGNC:7807])

HSP 1 Score: 125.176 bits (313), Expect = 2.214e-29
Identity = 104/359 (28.97%), Postives = 195/359 (54.32%), Query Frame = 2

Query:  665 WIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNELKKEIATAK-IIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDFK-PGKKIKEQLGKLIHEGEVKRSNKNPXXXXXXXXXXXXXXWFILTSEYLLMTKLSKKEVTYNVDDYCSSSEIFVEYETIEENG----NIFQFKLQINRNSDVCDVYLIQTKNKESHKKWMNLLS 1723
            W +  +++S G+ + ++ EEIK QE+ FE+++SEASY +SL++L+  F        +E   I+ I+ P +   LFSN+L +  +S +FL +LE R  E+  I+D+ DIV +YA + F VY+ Y+ NQ +Q   Y +L +E A  + +I +LE  P+C  L   SFL+LP QR+ R+ LL++ +    + + +     +D A + +E ++  C+E    +   ++M+ I + ++FK     I      L+ +GE+++ +   + + +     F E +  L ++ L++ +    +  Y V D  S+    +  E +E+ G    N+F  +L  N + D    Y+++  ++   K+WM  L+
Sbjct:  160 WQDLPEIRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHF--------MENERIRKILHPSEAHILFSNVLDVLAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTALD-AHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGD-KYQVFD--SAPRGLLRVEELEDQGQTLANVFILRLLENAD-DREATYMLKASSQSEMKRWMTSLA 505

[Close]

BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Human
Match: NGEF (neuronal guanine nucleotide exchange factor [Source:HGNC Symbol;Acc:HGNC:7807])

HSP 1 Score: 124.79 bits (312), Expect = 4.311e-29
Identity = 104/359 (28.97%), Postives = 195/359 (54.32%), Query Frame = 2

Query:  665 WIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNELKKEIATAK-IIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDFK-PGKKIKEQLGKLIHEGEVKRSNKNPXXXXXXXXXXXXXXWFILTSEYLLMTKLSKKEVTYNVDDYCSSSEIFVEYETIEENG----NIFQFKLQINRNSDVCDVYLIQTKNKESHKKWMNLLS 1723
            W +  +++S G+ + ++ EEIK QE+ FE+++SEASY +SL++L+  F        +E   I+ I+ P +   LFSN+L +  +S +FL +LE R  E+  I+D+ DIV +YA + F VY+ Y+ NQ +Q   Y +L +E A  + +I +LE  P+C  L   SFL+LP QR+ R+ LL++ +    + + +     +D A + +E ++  C+E    +   ++M+ I + ++FK     I      L+ +GE+++ +   + + +     F E +  L ++ L++ +    +  Y V D  S+    +  E +E+ G    N+F  +L  N + D    Y+++  ++   K+WM  L+
Sbjct:  252 WQDLPEIRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHF--------MENERIRKILHPSEAHILFSNVLDVLAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTALD-AHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGD-KYQVFD--SAPRGLLRVEELEDQGQTLANVFILRLLENAD-DREATYMLKASSQSEMKRWMTSLA 597

[Close]

BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Human
Match: ARHGEF15 (Rho guanine nucleotide exchange factor 15 [Source:HGNC Symbol;Acc:HGNC:15590])

HSP 1 Score: 111.309 bits (277), Expect = 7.735e-25
Identity = 82/238 (34.45%), Postives = 130/238 (54.62%), Query Frame = 2

Query:  653 RNLKWIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNELK-KEIATAKIIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDF 1363
            RN  W E   V++ GL   +  +E + QES FE+++SEASY RSL +L D F        V +  ++  + P     LFSN+ ++  +S +FLA L  R   S  I+DL D+V  +AV  F VYV Y++NQ++Q E Y+ L    +  +  +  L+S P+C  L L SFLLLP QR+ R+ +LL+ +    + +     E   KA+  + KII +CS     + + + ++ + + L F
Sbjct:  213 RNTLWQELPAVQASGLLDTLSPQERRMQESLFEVVTSEASYLRSLRLLTDTF--------VLSQALRDTLTPRDHHTLFSNVQRVQGVSERFLATLLSRVRSSPHISDLCDVVHAHAVGPFSVYVDYVRNQQYQEETYSRLMDTNVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILRQTE-EGSSRQENAQKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRF 441

[Close]

BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Human
Match: ARHGEF15 (Rho guanine nucleotide exchange factor 15 [Source:HGNC Symbol;Acc:HGNC:15590])

HSP 1 Score: 111.694 bits (278), Expect = 9.177e-25
Identity = 85/251 (33.86%), Postives = 133/251 (52.99%), Query Frame = 2

Query:  614 RKPGKICQELKENRNLKWIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNEL-KKEIATAKIIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDF 1363
            R PG         RN  W E   V++ GL   +  +E + QES FE+++SEASY RSL +L D F        V +  ++  + P     LFSN+ ++  +S +FLA L  R   S  I+DL D+V  +AV  F VYV Y++NQ++Q E Y+ L    +  +  +  L+S P+C  L L SFLLLP QR+ R+ +LL+ +    + +     E   KA+  + KII +CS     + + + ++ + + L F
Sbjct:  387 RPPGP--------RNTLWQELPAVQASGLLDTLSPQERRMQESLFEVVTSEASYLRSLRLLTDTF--------VLSQALRDTLTPRDHHTLFSNVQRVQGVSERFLATLLSRVRSSPHISDLCDVVHAHAVGPFSVYVDYVRNQQYQEETYSRLMDTNVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILRQTE-EGSSRQENAQKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRF 620

[Close]

BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Human
Match: ARHGEF15 (Rho guanine nucleotide exchange factor 15 [Source:HGNC Symbol;Acc:HGNC:15590])

HSP 1 Score: 111.694 bits (278), Expect = 9.177e-25
Identity = 85/251 (33.86%), Postives = 133/251 (52.99%), Query Frame = 2

Query:  614 RKPGKICQELKENRNLKWIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNEL-KKEIATAKIIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDF 1363
            R PG         RN  W E   V++ GL   +  +E + QES FE+++SEASY RSL +L D F        V +  ++  + P     LFSN+ ++  +S +FLA L  R   S  I+DL D+V  +AV  F VYV Y++NQ++Q E Y+ L    +  +  +  L+S P+C  L L SFLLLP QR+ R+ +LL+ +    + +     E   KA+  + KII +CS     + + + ++ + + L F
Sbjct:  387 RPPGP--------RNTLWQELPAVQASGLLDTLSPQERRMQESLFEVVTSEASYLRSLRLLTDTF--------VLSQALRDTLTPRDHHTLFSNVQRVQGVSERFLATLLSRVRSSPHISDLCDVVHAHAVGPFSVYVDYVRNQQYQEETYSRLMDTNVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILRQTE-EGSSRQENAQKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRF 620

[Close]

BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Celegans
Match: ephx-1 (EPHeXin (Eph-interacting GEF) homolog [Source:UniProtKB/TrEMBL;Acc:A0A1D3PD25])

HSP 1 Score: 95.9005 bits (237), Expect = 2.105e-20
Identity = 55/157 (35.03%), Postives = 85/157 (54.14%), Query Frame = 2

Query:  665 WIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNELKKE-IATAKIIEELESQPEC 1132
            W E  +V++ GL + +  E    QE+ FE+I+SEASY RSL+VLI  F  +PQM  + +     ++    ++HLFSNI  +   S + L DLE R  E+  + D+ DI++ +    F+VY+ Y  NQ +Q      LK E       ++ LE   +C
Sbjct:  149 WCELPEVRAAGLLEKLDDECKLRQEAYFEVITSEASYLRSLNVLITHFMASPQM--LGSKSALSVLSDSDRKHLFSNIFAVRDCSERLLCDLETRLEENLILDDICDILSDHFDKHFEVYIKYCSNQVYQDRTLRRLKTENPGFLSAVQRLEENKQC 303

[Close]

BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Celegans
Match: ephx-1 (EPHeXin (Eph-interacting GEF) homolog [Source:UniProtKB/TrEMBL;Acc:A0A1D3PD25])

HSP 1 Score: 95.9005 bits (237), Expect = 2.890e-20
Identity = 55/157 (35.03%), Postives = 85/157 (54.14%), Query Frame = 2

Query:  665 WIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNELKKE-IATAKIIEELESQPEC 1132
            W E  +V++ GL + +  E    QE+ FE+I+SEASY RSL+VLI  F  +PQM  + +     ++    ++HLFSNI  +   S + L DLE R  E+  + D+ DI++ +    F+VY+ Y  NQ +Q      LK E       ++ LE   +C
Sbjct:  193 WCELPEVRAAGLLEKLDDECKLRQEAYFEVITSEASYLRSLNVLITHFMASPQM--LGSKSALSVLSDSDRKHLFSNIFAVRDCSERLLCDLETRLEENLILDDICDILSDHFDKHFEVYIKYCSNQVYQDRTLRRLKTENPGFLSAVQRLEENKQC 347

[Close]

BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Celegans
Match: ephx-1 (EPHeXin (Eph-interacting GEF) homolog [Source:UniProtKB/TrEMBL;Acc:A0A1D3PD25])

HSP 1 Score: 95.5153 bits (236), Expect = 4.660e-20
Identity = 55/157 (35.03%), Postives = 85/157 (54.14%), Query Frame = 2

Query:  665 WIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNELKKE-IATAKIIEELESQPEC 1132
            W E  +V++ GL + +  E    QE+ FE+I+SEASY RSL+VLI  F  +PQM  + +     ++    ++HLFSNI  +   S + L DLE R  E+  + D+ DI++ +    F+VY+ Y  NQ +Q      LK E       ++ LE   +C
Sbjct:  520 WCELPEVRAAGLLEKLDDECKLRQEAYFEVITSEASYLRSLNVLITHFMASPQM--LGSKSALSVLSDSDRKHLFSNIFAVRDCSERLLCDLETRLEENLILDDICDILSDHFDKHFEVYIKYCSNQVYQDRTLRRLKTENPGFLSAVQRLEENKQC 674

[Close]

BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Celegans
Match: ephx-1 (EPHeXin (Eph-interacting GEF) homolog [Source:UniProtKB/TrEMBL;Acc:A0A1D3PD25])

HSP 1 Score: 95.5153 bits (236), Expect = 5.267e-20
Identity = 55/157 (35.03%), Postives = 85/157 (54.14%), Query Frame = 2

Query:  665 WIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNELKKE-IATAKIIEELESQPEC 1132
            W E  +V++ GL + +  E    QE+ FE+I+SEASY RSL+VLI  F  +PQM  + +     ++    ++HLFSNI  +   S + L DLE R  E+  + D+ DI++ +    F+VY+ Y  NQ +Q      LK E       ++ LE   +C
Sbjct:  660 WCELPEVRAAGLLEKLDDECKLRQEAYFEVITSEASYLRSLNVLITHFMASPQM--LGSKSALSVLSDSDRKHLFSNIFAVRDCSERLLCDLETRLEENLILDDICDILSDHFDKHFEVYIKYCSNQVYQDRTLRRLKTENPGFLSAVQRLEENKQC 814

[Close]

BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Fly
Match: Exn (gene:FBgn0261547 transcript:FBtr0302647)

HSP 1 Score: 78.5666 bits (192), Expect = 1.170e-14
Identity = 75/256 (29.30%), Postives = 132/256 (51.56%), Query Frame = 2

Query:  617 KPGKICQELKENRNLK----WIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNEL---KKEIATAKIIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDF 1363
            KP     +L E +N      W E  +V    +   +   E   QE++FEII+SEASY +SL++L   F N    + ++++    ++    ++ LFS I+ ++  S + L +LE  + ++  +  LS  + + A   F VYV + ++Q         L   K+ +A  + +E LE+ P CC L+L SFL+LPMQR+ R+ LL+ AV +   P  +   E     +  ++K++ +C+E  N  ++   +  I R L+F
Sbjct:  556 KPRPTALQLVEPKNGPSRTLWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMN--HNAFLDSS----VLSAKDRKALFSYIVPVHECSERLLTELEACWQDNIMLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAVFSKESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIARQLEF 805

[Close]

BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Fly
Match: Exn (gene:FBgn0261547 transcript:FBtr0302648)

HSP 1 Score: 78.5666 bits (192), Expect = 1.170e-14
Identity = 75/256 (29.30%), Postives = 132/256 (51.56%), Query Frame = 2

Query:  617 KPGKICQELKENRNLK----WIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNEL---KKEIATAKIIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDF 1363
            KP     +L E +N      W E  +V    +   +   E   QE++FEII+SEASY +SL++L   F N    + ++++    ++    ++ LFS I+ ++  S + L +LE  + ++  +  LS  + + A   F VYV + ++Q         L   K+ +A  + +E LE+ P CC L+L SFL+LPMQR+ R+ LL+ AV +   P  +   E     +  ++K++ +C+E  N  ++   +  I R L+F
Sbjct:  556 KPRPTALQLVEPKNGPSRTLWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMN--HNAFLDSS----VLSAKDRKALFSYIVPVHECSERLLTELEACWQDNIMLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAVFSKESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIARQLEF 805

[Close]

BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Fly
Match: Exn (gene:FBgn0261547 transcript:FBtr0302649)

HSP 1 Score: 78.5666 bits (192), Expect = 1.170e-14
Identity = 75/256 (29.30%), Postives = 132/256 (51.56%), Query Frame = 2

Query:  617 KPGKICQELKENRNLK----WIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNEL---KKEIATAKIIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDF 1363
            KP     +L E +N      W E  +V    +   +   E   QE++FEII+SEASY +SL++L   F N    + ++++    ++    ++ LFS I+ ++  S + L +LE  + ++  +  LS  + + A   F VYV + ++Q         L   K+ +A  + +E LE+ P CC L+L SFL+LPMQR+ R+ LL+ AV +   P  +   E     +  ++K++ +C+E  N  ++   +  I R L+F
Sbjct:  556 KPRPTALQLVEPKNGPSRTLWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMN--HNAFLDSS----VLSAKDRKALFSYIVPVHECSERLLTELEACWQDNIMLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAVFSKESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIARQLEF 805

[Close]

BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Fly
Match: Exn (gene:FBgn0261547 transcript:FBtr0302651)

HSP 1 Score: 77.411 bits (189), Expect = 3.496e-14
Identity = 75/256 (29.30%), Postives = 132/256 (51.56%), Query Frame = 2

Query:  617 KPGKICQELKENRNLK----WIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNEL---KKEIATAKIIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDF 1363
            KP     +L E +N      W E  +V    +   +   E   QE++FEII+SEASY +SL++L   F N    + ++++    ++    ++ LFS I+ ++  S + L +LE  + ++  +  LS  + + A   F VYV + ++Q         L   K+ +A  + +E LE+ P CC L+L SFL+LPMQR+ R+ LL+ AV +   P  +   E     +  ++K++ +C+E  N  ++   +  I R L+F
Sbjct: 1534 KPRPTALQLVEPKNGPSRTLWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMN--HNAFLDSS----VLSAKDRKALFSYIVPVHECSERLLTELEACWQDNIMLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAVFSKESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIARQLEF 1783

[Close]

BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Fly
Match: Exn (gene:FBgn0261547 transcript:FBtr0302650)

HSP 1 Score: 77.411 bits (189), Expect = 3.496e-14
Identity = 75/256 (29.30%), Postives = 132/256 (51.56%), Query Frame = 2

Query:  617 KPGKICQELKENRNLK----WIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNEL---KKEIATAKIIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDF 1363
            KP     +L E +N      W E  +V    +   +   E   QE++FEII+SEASY +SL++L   F N    + ++++    ++    ++ LFS I+ ++  S + L +LE  + ++  +  LS  + + A   F VYV + ++Q         L   K+ +A  + +E LE+ P CC L+L SFL+LPMQR+ R+ LL+ AV +   P  +   E     +  ++K++ +C+E  N  ++   +  I R L+F
Sbjct: 1534 KPRPTALQLVEPKNGPSRTLWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMN--HNAFLDSS----VLSAKDRKALFSYIVPVHECSERLLTELEACWQDNIMLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAVFSKESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIARQLEF 1783

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BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Zebrafish
Match: arhgef15 (Rho guanine nucleotide exchange factor (GEF) 15 [Source:ZFIN;Acc:ZDB-GENE-060526-292])

HSP 1 Score: 102.449 bits (254), Expect = 1.741e-22
Identity = 58/157 (36.94%), Postives = 97/157 (61.78%), Query Frame = 2

Query:  665 WIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNELKKE-IATAKIIEELESQPEC 1132
            W +   VK  G+   + + E + QES FE+++SEASY RSL VL D F  + +++  ET  I      + ++ LFSN+L++Y +S +F+ DL +R  ES  I+D+SDI+ +++ N F VY+ Y++NQ++Q + Y++L +     A ++  LE  P C
Sbjct:   69 WQDLPVVKESGMLHKLTRTEKQRQESMFEVLTSEASYLRSLRVLKDHFLGSRELN--ETLVI------HDRKVLFSNLLQVYEVSERFIRDLLKRVDESVVISDVSDIIYEHSENHFSVYIDYVRNQQYQEKTYSKLMESNTDFAVVMRRLELSPLC 217

[Close]

BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Zebrafish
Match: ngef (neuronal guanine nucleotide exchange factor [Source:ZFIN;Acc:ZDB-GENE-130530-794])

HSP 1 Score: 102.834 bits (255), Expect = 2.769e-22
Identity = 105/362 (29.01%), Postives = 179/362 (49.45%), Query Frame = 2

Query:  665 WIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNELKKE-IATAKIIEELESQPEC----CXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDFKP-GKKIKEQLGKLIHEGEVKRSNKNPXXXXXXXXXXXXXXWFILTSEYLLMTKLSKKEVTYNVDDYCSSSEIFVEYETIEENGNIFQ--FKLQINRNSDVCDV-YLIQTKNKESHKKWMNLLS 1723
            W   + VK  GL + ++ +EI  QE+ FE+++SEASY +SL +L   F   P   LV T      +       LFSNI  I   S KFL DLE R  ES  I+D+ DIV  +AVN F V++ Y+ NQ +Q   Y  + +E  A  + +  LE+QP+      +  L        +  L +  +LK V  N++ ++  ++     A Q +EKI+ +C+E    +   + ++ I + L+FK     +      L+ +GEV++ +   S + M     +   +  L +  LL+TK +     + V D CS S   +  E +E+ G +    F L++  N +  +V Y+++T++     +W+  L+
Sbjct:  250 WQNLDAVKKSGLLQTLEPKEIILQEAMFELVTSEASYYKSLELLETHFLRNPL--LVNT------LSQSDMHFLFSNITDIMKASEKFLMDLEHRIEESILISDVCDIVHFHAVNHFQVFISYVINQVYQETNYRRILQENCAFRENMAILENQPKVKGLSFTSFLILPFQRITRLKLLVQNILKRVEENSEKERTAIL-----AHQELEKIVKQCNEGARKMSRTEELISIEKTLEFKSKSVPVISHSRWLLKKGEVQQMSGPKSTRTMRSRKLYHPIYLFLFNNLLLITKRNSSGDKFQVLDSCSRS--MLRTEDLEDQGQMLACVFVLKLLENQEDREVSYMLKTESVSDKLRWICALT 596

[Close]

BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Zebrafish
Match: ngef (neuronal guanine nucleotide exchange factor [Source:ZFIN;Acc:ZDB-GENE-130530-794])

HSP 1 Score: 102.449 bits (254), Expect = 2.981e-22
Identity = 105/362 (29.01%), Postives = 179/362 (49.45%), Query Frame = 2

Query:  665 WIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNELKKE-IATAKIIEELESQPEC----CXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDFKP-GKKIKEQLGKLIHEGEVKRSNKNPXXXXXXXXXXXXXXWFILTSEYLLMTKLSKKEVTYNVDDYCSSSEIFVEYETIEENGNIFQ--FKLQINRNSDVCDV-YLIQTKNKESHKKWMNLLS 1723
            W   + VK  GL + ++ +EI  QE+ FE+++SEASY +SL +L   F   P   LV T      +       LFSNI  I   S KFL DLE R  ES  I+D+ DIV  +AVN F V++ Y+ NQ +Q   Y  + +E  A  + +  LE+QP+      +  L        +  L +  +LK V  N++ ++  ++     A Q +EKI+ +C+E    +   + ++ I + L+FK     +      L+ +GEV++ +   S + M     +   +  L +  LL+TK +     + V D CS S   +  E +E+ G +    F L++  N +  +V Y+++T++     +W+  L+
Sbjct:  109 WQNLDAVKKSGLLQTLEPKEIILQEAMFELVTSEASYYKSLELLETHFLRNPL--LVNT------LSQSDMHFLFSNITDIMKASEKFLMDLEHRIEESILISDVCDIVHFHAVNHFQVFISYVINQVYQETNYRRILQENCAFRENMAILENQPKVKGLSFTSFLILPFQRITRLKLLVQNILKRVEENSEKERTAIL-----AHQELEKIVKQCNEGARKMSRTEELISIEKTLEFKSKSVPVISHSRWLLKKGEVQQMSGPKSTRTMRSRKLYHPIYLFLFNNLLLITKRNSSGDKFQVLDSCSRS--MLRTEDLEDQGQMLACVFVLKLLENQEDREVSYMLKTESVSDKLRWICALT 455

[Close]

BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Zebrafish
Match: arhgef15 (Rho guanine nucleotide exchange factor (GEF) 15 [Source:ZFIN;Acc:ZDB-GENE-060526-292])

HSP 1 Score: 102.834 bits (255), Expect = 4.040e-22
Identity = 58/157 (36.94%), Postives = 97/157 (61.78%), Query Frame = 2

Query:  665 WIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNEL-KKEIATAKIIEELESQPEC 1132
            W +   VK  G+   + + E + QES FE+++SEASY RSL VL D F  + +++  ET  I      + ++ LFSN+L++Y +S +F+ DL +R  ES  I+D+SDI+ +++ N F VY+ Y++NQ++Q + Y++L +     A ++  LE  P C
Sbjct:  470 WQDLPVVKESGMLHKLTRTEKQRQESMFEVLTSEASYLRSLRVLKDHFLGSRELN--ETLVI------HDRKVLFSNLLQVYEVSERFIRDLLKRVDESVVISDVSDIIYEHSENHFSVYIDYVRNQQYQEKTYSKLMESNTDFAVVMRRLELSPLC 618

[Close]

BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Zebrafish
Match: si:dkey-38p12.3 (si:dkey-38p12.3 [Source:ZFIN;Acc:ZDB-GENE-060810-103])

HSP 1 Score: 93.5893 bits (231), Expect = 1.602e-19
Identity = 104/323 (32.20%), Postives = 166/323 (51.39%), Query Frame = 2

Query:  635 QELKENRNLKWIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAY-NELKKEIATAKIIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAV--RTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDFKPGKKIK--EQLGKLIHEGEVKRSNKNPXXXXXXXXXXXXXXWFILTSEYLLMTKLSKKEVTYNVDDYCSSSEIFVE 1588
            Q LK+N NL W E   V+  G+ + +  EE K+QES FE+I+SE SY RSL VL + F        VE++ +   +    K+ LFSNI++I  +S +FL DLE R  E+  I+D+ DI+  +A + F  Y+ Y++NQ +Q + Y N ++     A +I  L+  P+C  L   SFLLLP QR+ RI +L++ +  RT     ++       KA+  + KII +C+     + + + +++I   L+F   K +    Q   L  +GEV   NK  +            + F+     LL+  + K    Y V D+   S + V+
Sbjct:   56 QSLKQN-NL-WREQSAVRDSGVLEKLSPEECKYQESMFEVITSEMSYLRSLRVLTEHF--------VESSELNETLIIMDKKTLFSNIIRIQEVSERFLKDLEERLDENIIISDICDIIHYHAQHHFPAYIDYVRNQIYQEKTYSNLMQTNTQFATVITRLQESPKCQRLPFMSFLLLPFQRITRIKMLIENILKRTAVGTDKEQT---ASKALDSVSKIIEECNTQVGKMKQMEELIQINGMLEFDKLKAVPIISQTRYLEKQGEVLEVNKGGTFLGNLRPKFTPVYLFLFND--LLVIAIKKSAERYVVLDHAHRSLVQVQ 363

[Close]

BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Xenopus
Match: ARHGEF26 (Rho guanine nucleotide exchange factor 26 [Source:NCBI gene;Acc:100495357])

HSP 1 Score: 112.079 bits (279), Expect = 6.973e-25
Identity = 117/359 (32.59%), Postives = 186/359 (51.81%), Query Frame = 2

Query:  539 NNQEALNDIDLVDCIFKDDRSRNSSRKPGKICQELKENRNLKWIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNELKKEIATAK-IIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDFK--PGKKIKEQLGKLIHEGEVKRSNKNPXXXXXXXXXXXXXXWFILTSEYLLMTKLSKKEVTYNVDDYCSSSEIFVEYETIEE 1606
            N +E   DID       D+ + +  +K  +I  E K  R+  W +   V+  GL++++ +EE K QE+ FE+ISSE SY  SL +LI  F N+ Q+S   T          +  HLFSNI  +Y  S KF  +LE R   +  I D+SDIV K+A   FD YV Y  N+ +Q      L    ++ K ++ ++ES  EC +L + SFL+LPMQR+ R+ LL+  +     P++    E    A++ + K++  C+E    ++  + M+ I   L+FK  P   +      L+  GE+    ++      S+    ++F+F L ++ L++TK  K E +YNV DYC   ++ VE    EE
Sbjct:  381 NYKEKALDID------SDEDADSKEQKEDRIIVEYKPLRS-TWSQLSVVRKNGLSQSVSQEERKRQEAMFEVISSEHSYLLSLEILIRMFKNSKQLSATMTKT--------ESHHLFSNITDVYEASKKFFKELEGRHQRNILIEDISDIVEKHAKATFDPYVKYCTNEVYQQRTLQRLILTNSSFKEVLSKIESHEECRNLPMISFLILPMQRVTRLPLLMDTI-CQKTPKESAKYEASKHALKEVGKLVRLCNEGARKMERMEMMVTINSQLEFKIKPFPLVSSSRW-LLKRGELTAYVED--TGIFSKRTTKQQFYFFLFNDVLIITK-KKSEESYNVTDYCLREKLLVEQNDNEE 719

[Close]

BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Xenopus
Match: ARHGEF26 (Rho guanine nucleotide exchange factor 26 [Source:NCBI gene;Acc:100495357])

HSP 1 Score: 111.694 bits (278), Expect = 8.022e-25
Identity = 117/359 (32.59%), Postives = 186/359 (51.81%), Query Frame = 2

Query:  539 NNQEALNDIDLVDCIFKDDRSRNSSRKPGKICQELKENRNLKWIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNELKKEIATAK-IIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDFK--PGKKIKEQLGKLIHEGEVKRSNKNPXXXXXXXXXXXXXXWFILTSEYLLMTKLSKKEVTYNVDDYCSSSEIFVEYETIEE 1606
            N +E   DID       D+ + +  +K  +I  E K  R+  W +   V+  GL++++ +EE K QE+ FE+ISSE SY  SL +LI  F N+ Q+S   T          +  HLFSNI  +Y  S KF  +LE R   +  I D+SDIV K+A   FD YV Y  N+ +Q      L    ++ K ++ ++ES  EC +L + SFL+LPMQR+ R+ LL+  +     P++    E    A++ + K++  C+E    ++  + M+ I   L+FK  P   +      L+  GE+    ++      S+    ++F+F L ++ L++TK  K E +YNV DYC   ++ VE    EE
Sbjct:  381 NYKEKALDID------SDEDADSKEQKEDRIIVEYKPLRS-TWSQLSVVRKNGLSQSVSQEERKRQEAMFEVISSEHSYLLSLEILIRMFKNSKQLSATMTKT--------ESHHLFSNITDVYEASKKFFKELEGRHQRNILIEDISDIVEKHAKATFDPYVKYCTNEVYQQRTLQRLILTNSSFKEVLSKIESHEECRNLPMISFLILPMQRVTRLPLLMDTI-CQKTPKESAKYEASKHALKEVGKLVRLCNEGARKMERMEMMVTINSQLEFKIKPFPLVSSSRW-LLKRGELTAYVED--TGIFSKRTTKQQFYFFLFNDVLIITK-KKSEESYNVTDYCLREKLLVEQNDNEE 719

[Close]

BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Xenopus
Match: ARHGEF26 (Rho guanine nucleotide exchange factor 26 [Source:NCBI gene;Acc:100495357])

HSP 1 Score: 111.694 bits (278), Expect = 8.231e-25
Identity = 117/359 (32.59%), Postives = 186/359 (51.81%), Query Frame = 2

Query:  539 NNQEALNDIDLVDCIFKDDRSRNSSRKPGKICQELKENRNLKWIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNELKKEIATAK-IIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDFK--PGKKIKEQLGKLIHEGEVKRSNKNPXXXXXXXXXXXXXXWFILTSEYLLMTKLSKKEVTYNVDDYCSSSEIFVEYETIEE 1606
            N +E   DID       D+ + +  +K  +I  E K  R+  W +   V+  GL++++ +EE K QE+ FE+ISSE SY  SL +LI  F N+ Q+S   T          +  HLFSNI  +Y  S KF  +LE R   +  I D+SDIV K+A   FD YV Y  N+ +Q      L    ++ K ++ ++ES  EC +L + SFL+LPMQR+ R+ LL+  +     P++    E    A++ + K++  C+E    ++  + M+ I   L+FK  P   +      L+  GE+    ++      S+    ++F+F L ++ L++TK  K E +YNV DYC   ++ VE    EE
Sbjct:  381 NYKEKALDID------SDEDADSKEQKEDRIIVEYKPLRS-TWSQLSVVRKNGLSQSVSQEERKRQEAMFEVISSEHSYLLSLEILIRMFKNSKQLSATMTKT--------ESHHLFSNITDVYEASKKFFKELEGRHQRNILIEDISDIVEKHAKATFDPYVKYCTNEVYQQRTLQRLILTNSSFKEVLSKIESHEECRNLPMISFLILPMQRVTRLPLLMDTI-CQKTPKESAKYEASKHALKEVGKLVRLCNEGARKMERMEMMVTINSQLEFKIKPFPLVSSSRW-LLKRGELTAYVED--TGIFSKRTTKQQFYFFLFNDVLIITK-KKSEESYNVTDYCLREKLLVEQNDNEE 719

[Close]

BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Xenopus
Match: NGEF (neuronal guanine nucleotide exchange factor [Source:NCBI gene;Acc:100487663])

HSP 1 Score: 107.071 bits (266), Expect = 1.975e-23
Identity = 106/391 (27.11%), Postives = 201/391 (51.41%), Query Frame = 2

Query:  665 WIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNELKKEIATAK-IIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDFK-PGKKIKEQLGKLIHEGEVKRSNKNPXXXXXXXXXXXXXXWFILTSEYLLMTKLSKKEVTYNVDDYCSSSEIFVEYETIEENG----NIFQFKLQINRNSDVCDVYLIQTKNKESHKKWM-NLLSNS*ERSEIVKM--------HIICIFIIISDE 1792
            W +   V+  G+   ++ EE+K QE+ FE+++SEASY +SL +++  F        +++  ++  +   +   +FSN+L++   S +FL  LE+RF E+  I+D+ DIV ++A   F VYV Y+ NQ +Q  AY +L +E    +  +  LE+ P C  L   SFL+LP QR+ R+ LL++ + T  +   +  +  + +A + +EK++  C++    +   ++++ I + L+FK     I      L+ +GE+++ +   + + +     F+  +  L ++ LLM K    E  Y V D  +     +  E +E+ G    N+F  KL  N +      Y+++  ++   K+WM +L+ N   R++ V M         + C+   +S E
Sbjct:  235 WQDLPDVRKSGVLALLQPEEVKLQEAMFELLTSEASYYKSLRLVVSHF--------MDSERLRASLHQSEIHFIFSNVLEVLATSERFLLALEQRFEENIVISDVCDIVYEHAEKHFVVYVTYVCNQTYQERAYRKLLQERPEFRESVGHLETDPVCRGLPFSSFLILPFQRITRLKLLVQNILTKVEEGSEREVSAL-QAHRELEKLVRACNDGVRKMSRTEQLISIEKTLEFKIKSVPIISHSRWLMKQGELQQMSGPRTSRTLRTKKLFRPVYLFLFNDLLLMCKPLTGE-RYQVFDVAARG--LLRVEELEDQGQTLANVFILKLLENAHEREF-TYMLKATSQSEMKRWMTSLVPN--RRTKFVSMSAKLLDCPQVQCVHPYVSQE 610

[Close]

BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Xenopus
Match: NGEF (neuronal guanine nucleotide exchange factor [Source:NCBI gene;Acc:100487663])

HSP 1 Score: 106.301 bits (264), Expect = 2.349e-23
Identity = 106/391 (27.11%), Postives = 201/391 (51.41%), Query Frame = 2

Query:  665 WIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNELKKEIATAK-IIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDFK-PGKKIKEQLGKLIHEGEVKRSNKNPXXXXXXXXXXXXXXWFILTSEYLLMTKLSKKEVTYNVDDYCSSSEIFVEYETIEENG----NIFQFKLQINRNSDVCDVYLIQTKNKESHKKWM-NLLSNS*ERSEIVKM--------HIICIFIIISDE 1792
            W +   V+  G+   ++ EE+K QE+ FE+++SEASY +SL +++  F        +++  ++  +   +   +FSN+L++   S +FL  LE+RF E+  I+D+ DIV ++A   F VYV Y+ NQ +Q  AY +L +E    +  +  LE+ P C  L   SFL+LP QR+ R+ LL++ + T  +   +  +  + +A + +EK++  C++    +   ++++ I + L+FK     I      L+ +GE+++ +   + + +     F+  +  L ++ LLM K    E  Y V D  +     +  E +E+ G    N+F  KL  N +      Y+++  ++   K+WM +L+ N   R++ V M         + C+   +S E
Sbjct:  144 WQDLPDVRKSGVLALLQPEEVKLQEAMFELLTSEASYYKSLRLVVSHF--------MDSERLRASLHQSEIHFIFSNVLEVLATSERFLLALEQRFEENIVISDVCDIVYEHAEKHFVVYVTYVCNQTYQERAYRKLLQERPEFRESVGHLETDPVCRGLPFSSFLILPFQRITRLKLLVQNILTKVEEGSEREVSAL-QAHRELEKLVRACNDGVRKMSRTEQLISIEKTLEFKIKSVPIISHSRWLMKQGELQQMSGPRTSRTLRTKKLFRPVYLFLFNDLLLMCKPLTGE-RYQVFDVAARG--LLRVEELEDQGQTLANVFILKLLENAHEREF-TYMLKATSQSEMKRWMTSLVPN--RRTKFVSMSAKLLDCPQVQCVHPYVSQE 519

[Close]

BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Mouse
Match: Ngef (neuronal guanine nucleotide exchange factor [Source:MGI Symbol;Acc:MGI:1858414])

HSP 1 Score: 122.865 bits (307), Expect = 9.389e-29
Identity = 103/359 (28.69%), Postives = 195/359 (54.32%), Query Frame = 2

Query:  665 WIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNELKKEIATAK-IIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDFK-PGKKIKEQLGKLIHEGEVKRSNKNPXXXXXXXXXXXXXXWFILTSEYLLMTKLSKKEVTYNVDDYCSSSEIFVEYETIEENG----NIFQFKLQINRNSDVCDVYLIQTKNKESHKKWMNLLS 1723
            W +  +++S G+   ++ EEI+ QE+ FE+++SEASY +SL++L+  F        +E   +K I+ P +   LFSN+L +  +S +FL +LE R  E+  I+D+ DIV +YA + F VY+ Y+ NQ +Q   Y +L +E A  + +I +LE  P+C  L   SFL+LP QR+ R+ LL++ +    + + +     +D A + +E ++  C+E    +   ++M+ I + ++FK     I      L+ +GE+++ +   + + +     F+E +  L ++ L++ +    +  Y V D  S+    +  E +E+ G    N+F  +L  N + D    Y+++  ++   K+WM  L+
Sbjct:  162 WQDLPEIQSSGVLDILQPEEIRLQEAMFELVTSEASYYKSLNLLVSHF--------MENERLKKILHPSEAHILFSNVLDVMAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCKGLPFSSFLILPFQRITRLKLLVQNILKRVEERSEREGTALD-AHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFREIYLFLFNDLLVICRQIPGD-KYQVFD--SAPRGLLRVEELEDQGQTLANVFILRLLENAD-DREATYMLKASSQSEMKRWMTSLA 507

[Close]

BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Mouse
Match: Ngef (neuronal guanine nucleotide exchange factor [Source:MGI Symbol;Acc:MGI:1858414])

HSP 1 Score: 122.094 bits (305), Expect = 2.112e-28
Identity = 103/359 (28.69%), Postives = 195/359 (54.32%), Query Frame = 2

Query:  665 WIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNELKKEIATAK-IIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDFK-PGKKIKEQLGKLIHEGEVKRSNKNPXXXXXXXXXXXXXXWFILTSEYLLMTKLSKKEVTYNVDDYCSSSEIFVEYETIEENG----NIFQFKLQINRNSDVCDVYLIQTKNKESHKKWMNLLS 1723
            W +  +++S G+   ++ EEI+ QE+ FE+++SEASY +SL++L+  F        +E   +K I+ P +   LFSN+L +  +S +FL +LE R  E+  I+D+ DIV +YA + F VY+ Y+ NQ +Q   Y +L +E A  + +I +LE  P+C  L   SFL+LP QR+ R+ LL++ +    + + +     +D A + +E ++  C+E    +   ++M+ I + ++FK     I      L+ +GE+++ +   + + +     F+E +  L ++ L++ +    +  Y V D  S+    +  E +E+ G    N+F  +L  N + D    Y+++  ++   K+WM  L+
Sbjct:  252 WQDLPEIQSSGVLDILQPEEIRLQEAMFELVTSEASYYKSLNLLVSHF--------MENERLKKILHPSEAHILFSNVLDVMAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCKGLPFSSFLILPFQRITRLKLLVQNILKRVEERSEREGTALD-AHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFREIYLFLFNDLLVICRQIPGD-KYQVFD--SAPRGLLRVEELEDQGQTLANVFILRLLENAD-DREATYMLKASSQSEMKRWMTSLA 597

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BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Mouse
Match: Arhgef15 (Rho guanine nucleotide exchange factor (GEF) 15 [Source:MGI Symbol;Acc:MGI:3045246])

HSP 1 Score: 114.005 bits (284), Expect = 1.338e-25
Identity = 83/242 (34.30%), Postives = 133/242 (54.96%), Query Frame = 2

Query:  641 LKENRNLKWIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNEL-KKEIATAKIIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDF 1363
            L   RN  W E   V+  GL +++  +E + QES FE+++SEASY RSL +L D F        V +  ++  + P     LFSN+ ++ ++S +FL  L  R   S  ITDL D+V  +AV  F VYV Y++NQ++Q E Y+ L    +  +  +  L+S P+C  L L SFLLLP QR+ R+ +LL+ + +  + +     E   KA+  + KII +CS     + + + ++ + + L F
Sbjct:  396 LPGPRNTLWQELPAVRGSGLLESLSPQERRMQESLFEVVTSEASYLRSLRLLTDTF--------VLSQALRDTLTPRDHHTLFSNVQRVQSVSERFLGTLLSRVRSSPHITDLCDVVHAHAVGPFFVYVDYVRNQQYQEETYSRLMDTNVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILSQTE-EGSSRQENAQKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRF 628

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Query:  641 LKENRNLKWIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNEL-KKEIATAKIIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDF 1363
            L   RN  W E   V+  GL +++  +E + QES FE+++SEASY RSL +L D F        V +  ++  + P     LFSN+ ++ ++S +FL  L  R   S  ITDL D+V  +AV  F VYV Y++NQ++Q E Y+ L    +  +  +  L+S P+C  L L SFLLLP QR+ R+ +LL+ + +  + +     E   KA+  + KII +CS     + + + ++ + + L F
Sbjct:  396 LPGPRNTLWQELPAVRGSGLLESLSPQERRMQESLFEVVTSEASYLRSLRLLTDTF--------VLSQALRDTLTPRDHHTLFSNVQRVQSVSERFLGTLLSRVRSSPHITDLCDVVHAHAVGPFFVYVDYVRNQQYQEETYSRLMDTNVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILSQTE-EGSSRQENAQKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRF 628

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BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Mouse
Match: Arhgef26 (Rho guanine nucleotide exchange factor (GEF) 26 [Source:MGI Symbol;Acc:MGI:1918053])

HSP 1 Score: 107.457 bits (267), Expect = 1.530e-23
Identity = 114/400 (28.50%), Postives = 197/400 (49.25%), Query Frame = 2

Query:  665 WIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNELKKEIAT----AKIIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDF--KPGKKIKEQLGKLIHEGEVKRSNKNPXXXXXXXXXXXXXXWFILTSEYLLMTKLSKKEVTYNVDDYCSSSEIFVE-------------------YETIEENGNIFQFKLQINRNSDVCDVYLIQTKNKESHKKWMNLLSNS-----*ERSEIVKMHIICIF 1774
            W +   VK  GL++ + +EE K QE+ FE+ISSE SY  SL +LI  F N+ +++   T          ++ HLFSNI  ++  S KF  +LE R   +  I D+SDIV K+  + FD YV Y  N+ +Q      L+K +AT     +++  +ES  +C +L + SFL+LPMQR+ R+ LL+  +     P+     E+  +A++ + K++  C+E    ++  + M  I   L+F  KP   +      L+  GE+    ++      S+ M  ++ +F L ++ L++TK  K E +YNV+DY    ++ VE                   Y       ++F   +  N  S+  D+ L+  + +    +W+  L +S      +R+ + ++ II  F
Sbjct:  416 WSQLSAVKRNGLSQTVSQEERKRQEAIFEVISSEHSYLLSLEILIRMFKNSKELTDTMTK--------TERHHLFSNITDVWEASKKFFTELEARHQNNIFIEDISDIVEKHTASTFDPYVKYCTNEVYQQRT---LQKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTI-CQKTPKDSPKYEVCKRALKEVSKLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRW-LVKRGELTAYVED--TVLFSKRMSKQQVYFFLFNDVLIITK-KKSEESYNVNDYSLRDQLLVESCDNEELNSSPGKNPSTMLYSRQSSATHLFTLTVLSNHASEKVDM-LLGAETQSERARWITALGHSSGKQPPDRTTLTQVEIIRSF 798

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BLAST of Neuronal guanine nucleotide exchange factor vs. UniProt/SwissProt
Match: sp|Q5RDX5|NGEF_PONAB (Ephexin-1 OS=Pongo abelii OX=9601 GN=NGEF PE=2 SV=1)

HSP 1 Score: 125.561 bits (314), Expect = 1.358e-28
Identity = 104/359 (28.97%), Postives = 195/359 (54.32%), Query Frame = 2

Query:  665 WIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNELKKEIATAK-IIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDFK-PGKKIKEQLGKLIHEGEVKRSNKNPXXXXXXXXXXXXXXWFILTSEYLLMTKLSKKEVTYNVDDYCSSSEIFVEYETIEENG----NIFQFKLQINRNSDVCDVYLIQTKNKESHKKWMNLLS 1723
            W +  +++S G+ + ++ EEIK QE+ FE+++SEASY +SL++L+  F        +E   I+ I+ P +   LFSN+L +  +S +FL +LE R  E+  I+D+ DIV +YA + F VY+ Y+ NQ +Q   Y +L +E A  + +I +LE  P+C  L   SFL+LP QR+ R+ LL++ +    + + +     +D A + +E ++  C+E    +   ++M+ I + ++FK     I      L+ +GE+++ +   + + +     F E +  L ++ L++ +    +  Y V D  S+    +  E +E+ G    N+F  +L  N + D    Y+++  ++   K+WM  L+
Sbjct:  251 WQDLPEIRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHF--------MENERIRKILHPSEAHILFSNVLDVLAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTALD-AHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGD-KYQVFD--SAPRGLLRVEELEDQGQTLANVFILRLLENAD-DREATYMLKASSQSEMKRWMTSLA 596

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BLAST of Neuronal guanine nucleotide exchange factor vs. UniProt/SwissProt
Match: sp|Q8N5V2|NGEF_HUMAN (Ephexin-1 OS=Homo sapiens OX=9606 GN=NGEF PE=1 SV=2)

HSP 1 Score: 124.79 bits (312), Expect = 2.070e-28
Identity = 104/359 (28.97%), Postives = 195/359 (54.32%), Query Frame = 2

Query:  665 WIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNELKKEIATAK-IIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDFK-PGKKIKEQLGKLIHEGEVKRSNKNPXXXXXXXXXXXXXXWFILTSEYLLMTKLSKKEVTYNVDDYCSSSEIFVEYETIEENG----NIFQFKLQINRNSDVCDVYLIQTKNKESHKKWMNLLS 1723
            W +  +++S G+ + ++ EEIK QE+ FE+++SEASY +SL++L+  F        +E   I+ I+ P +   LFSN+L +  +S +FL +LE R  E+  I+D+ DIV +YA + F VY+ Y+ NQ +Q   Y +L +E A  + +I +LE  P+C  L   SFL+LP QR+ R+ LL++ +    + + +     +D A + +E ++  C+E    +   ++M+ I + ++FK     I      L+ +GE+++ +   + + +     F E +  L ++ L++ +    +  Y V D  S+    +  E +E+ G    N+F  +L  N + D    Y+++  ++   K+WM  L+
Sbjct:  252 WQDLPEIRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHF--------MENERIRKILHPSEAHILFSNVLDVLAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTALD-AHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGD-KYQVFD--SAPRGLLRVEELEDQGQTLANVFILRLLENAD-DREATYMLKASSQSEMKRWMTSLA 597

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BLAST of Neuronal guanine nucleotide exchange factor vs. UniProt/SwissProt
Match: sp|Q8CHT1|NGEF_MOUSE (Ephexin-1 OS=Mus musculus OX=10090 GN=Ngef PE=1 SV=1)

HSP 1 Score: 122.094 bits (305), Expect = 1.586e-27
Identity = 103/359 (28.69%), Postives = 195/359 (54.32%), Query Frame = 2

Query:  665 WIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNELKKEIATAK-IIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDFK-PGKKIKEQLGKLIHEGEVKRSNKNPXXXXXXXXXXXXXXWFILTSEYLLMTKLSKKEVTYNVDDYCSSSEIFVEYETIEENG----NIFQFKLQINRNSDVCDVYLIQTKNKESHKKWMNLLS 1723
            W +  +++S G+   ++ EEI+ QE+ FE+++SEASY +SL++L+  F        +E   +K I+ P +   LFSN+L +  +S +FL +LE R  E+  I+D+ DIV +YA + F VY+ Y+ NQ +Q   Y +L +E A  + +I +LE  P+C  L   SFL+LP QR+ R+ LL++ +    + + +     +D A + +E ++  C+E    +   ++M+ I + ++FK     I      L+ +GE+++ +   + + +     F+E +  L ++ L++ +    +  Y V D  S+    +  E +E+ G    N+F  +L  N + D    Y+++  ++   K+WM  L+
Sbjct:  252 WQDLPEIQSSGVLDILQPEEIRLQEAMFELVTSEASYYKSLNLLVSHF--------MENERLKKILHPSEAHILFSNVLDVMAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCKGLPFSSFLILPFQRITRLKLLVQNILKRVEERSEREGTALD-AHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFREIYLFLFNDLLVICRQIPGD-KYQVFD--SAPRGLLRVEELEDQGQTLANVFILRLLENAD-DREATYMLKASSQSEMKRWMTSLA 597

[Close]

BLAST of Neuronal guanine nucleotide exchange factor vs. UniProt/SwissProt
Match: sp|Q5BKC9|NGEF_RAT (Ephexin-1 OS=Rattus norvegicus OX=10116 GN=Ngef PE=1 SV=2)

HSP 1 Score: 120.168 bits (300), Expect = 6.226e-27
Identity = 104/359 (28.97%), Postives = 194/359 (54.04%), Query Frame = 2

Query:  665 WIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNELKKE-IATAKIIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDFK-PGKKIKEQLGKLIHEGEVKRSNKNPXXXXXXXXXXXXXXWFILTSEYLLMTKLSKKEVTYNVDDYCSSSEIFVEYETIEENG----NIFQFKLQINRNSDVCDVYLIQTKNKESHKKWMNLLS 1723
            W +  +++S G+   ++ EE K QE+ FE+++SEASY +SL++L+  F        +E   +K I+ P +   LFSN+L +  +S +FL +LE R  E+  I+D+ DIV +YA + F VY+ Y+ NQ +Q   Y +L +E  A  ++I +LE  P+C  L L SFL+LP QR+ R+ LL++ +    +   +     +D A + +E ++  C+E    +   ++M+ I + ++FK     I      L+ +GE+++ +   + + +     F+E +  L ++ L++ +    +  Y V D  S+    +  E +E+ G    N+F  +L  N + D    Y+++  ++   K+WM  L+
Sbjct:  243 WQDLPEIQSSGVLDILQPEETKLQEAMFELVTSEASYYKSLNLLVSHF--------MENERLKKILHPSEAHILFSNVLDVMAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKTAFRELIAQLELDPKCKGLPLSSFLILPFQRITRLKLLVQNILKRVEEGSEREGTALD-AHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFREIYLFLFNDLLVICRQIPGD-KYQVFD--SAPRGLLRVEELEDQGQTLANVFILRLLENAD-DREATYMLKASSQSEMKRWMTSLA 588

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BLAST of Neuronal guanine nucleotide exchange factor vs. UniProt/SwissProt
Match: sp|Q5FWH6|ARHGF_MOUSE (Rho guanine nucleotide exchange factor 15 OS=Mus musculus OX=10090 GN=Arhgef15 PE=1 SV=1)

HSP 1 Score: 114.005 bits (284), Expect = 9.361e-25
Identity = 83/242 (34.30%), Postives = 133/242 (54.96%), Query Frame = 2

Query:  641 LKENRNLKWIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNEL-KKEIATAKIIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDF 1363
            L   RN  W E   V+  GL +++  +E + QES FE+++SEASY RSL +L D F        V +  ++  + P     LFSN+ ++ ++S +FL  L  R   S  ITDL D+V  +AV  F VYV Y++NQ++Q E Y+ L    +  +  +  L+S P+C  L L SFLLLP QR+ R+ +LL+ + +  + +     E   KA+  + KII +CS     + + + ++ + + L F
Sbjct:  396 LPGPRNTLWQELPAVRGSGLLESLSPQERRMQESLFEVVTSEASYLRSLRLLTDTF--------VLSQALRDTLTPRDHHTLFSNVQRVQSVSERFLGTLLSRVRSSPHITDLCDVVHAHAVGPFFVYVDYVRNQQYQEETYSRLMDTNVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILSQTE-EGSSRQENAQKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRF 628

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BLAST of Neuronal guanine nucleotide exchange factor vs. TrEMBL
Match: A0A401PDJ3 (Uncharacterized protein OS=Scyliorhinus torazame OX=75743 GN=scyTo_0005868 PE=4 SV=1)

HSP 1 Score: 142.124 bits (357), Expect = 1.706e-31
Identity = 115/359 (32.03%), Postives = 195/359 (54.32%), Query Frame = 2

Query:  665 WIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNE-LKKEIATAKIIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDFK-PGKKIKEQLGKLIHEGEVKRSNKNPXXXXXXXXXXXXXXWFILTSEYLLMTKLSKKEVTYNVDDYCSSSEIFVEYETIEENG----NIFQFKLQINRNSDVCDVYLIQTKNKESHKKWMNLLS 1723
            W   E+V++  +   + ++EIK QE+ FE+++SEASYN+SL +LI  F  + Q+S          + P +K H+FSNIL I   S +F  DLE R  E   I+D+ DIV ++ VN F+VY+PY+ NQ +Q  AY   ++  +    ++ ELE  P+C  L   SFL+LP QR+ R+ LL++ +   A+ + K     V KA + +EK+I +CSE    +   ++++   + L+FK     I  Q   L+ +GE+++ +   + +   +   FK  + IL ++  L+TK       Y V DY       +  + +E+ G    NIF  +L +  N+D    Y+++ K+    K+W++ L+
Sbjct:  292 WQNLEKVRNSTVLSTLSRKEIKLQEAMFELVTSEASYNKSLEILIFHFMKSEQLS--------EALSPTEKHHIFSNILDIKAASERFFRDLEHRIEEDIVISDVCDIVYEHTVNHFNVYIPYVTNQSYQEAAYRRAMEHNLQFRNVMAELERDPKCRGLPFPSFLILPFQRITRLKLLVQNILKTAEEESKRESSAV-KAHRELEKVIKECSERVKKMGRTEQLINFEKKLEFKIKAVPIISQSRWLLKKGELEQMSGQKATRTFRKKKLFKPVYLILFNDLFLITKKHSYGDRYEVFDYALRG--LLRVQELEDQGQALANIFMLRL-LENNNDREVQYMLKAKSLSDKKRWVHALA 638

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BLAST of Neuronal guanine nucleotide exchange factor vs. TrEMBL
Match: A0A401T0V1 (Uncharacterized protein OS=Chiloscyllium punctatum OX=137246 GN=chiPu_0014772 PE=4 SV=1)

HSP 1 Score: 140.584 bits (353), Expect = 7.090e-31
Identity = 115/358 (32.12%), Postives = 193/358 (53.91%), Query Frame = 2

Query:  665 WIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNE-LKKEIATAKIIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDFK-PGKKIKEQLGKLIHEGEVKRSNKNPXXXXXXXXXXXXXXWFILTSEYLLMTKLSKKEVTYNVDDYCSSSEIFVEYETIEENG----NIFQFKLQINRNSDVCDVYLIQTKNKESHKKWMNLL 1720
            W   E+V++  +   + ++EIK QE+ FE+++SEASY +SL +L+  F  + Q+S          + P +K H+FSNIL I   S +F  DLE R  E   I+D+ DIV ++ VN F+VY+PY+ NQ +Q  AY   ++  +    ++ ELE  P+C  L   SFL+LP QR+ R+ LL++ +   A+ + K     V KA + +EK+I +CSE    +   ++++   + LDFK     I  Q   L+ EGE+++ +   + +   +   FK    IL ++  L+TK       Y V DY       +  + +E+ G    NIF  +L +  N+D    Y+++ K++   K+W++ L
Sbjct:  343 WQNLEKVRNSTVLSTLSRKEIKLQEAMFELVTSEASYYKSLEILVFHFMKSEQLS--------EALSPIEKHHIFSNILDIKAASERFFRDLEHRIEEDIVISDVCDIVYEHTVNHFNVYIPYVTNQSYQEAAYRRAMENNLQFRNVMAELEKDPKCRGLPFPSFLILPFQRITRLKLLVQNILKTAEEESKRESTAV-KAHKELEKVIKECSERVKKMGRTEQLISFEKKLDFKVKAVPIISQSRWLLKEGELEQMSGQKATRTFRKKKLFKPVHLILFNDLFLITKKHSYGDRYEVFDYALRG--LLRVQELEDQGQALANIFMLRL-LENNNDREVQYMLKAKSQSDKKRWVHAL 688

[Close]

BLAST of Neuronal guanine nucleotide exchange factor vs. TrEMBL
Match: A0A5K4E9M8 (Putative guanine-nucleotide-exchange-factor OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 140.584 bits (353), Expect = 8.033e-31
Identity = 124/364 (34.07%), Postives = 193/364 (53.02%), Query Frame = 2

Query:  593 DRSRN--SSRKPGKICQELKENRN---------LKWIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNELKKEIATAKIIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDFK-PGKKIKEQLGKLIHEGEVK-------RSNKNPXXXXXXXXXXXXXXWFILTSEYLLMTKLSKKEVTYNVDDYCSSSEIFVEYETIEENGNIFQF 1627
            +RS+N  S+ KP +  QE++   N         ++W E  QV S  LA+++   + K QE+ FE+I+SEASY R+L +LI+KFY AP M   + +    +I   +K HLFSNI +I+  S  FL D+E  F ++  I  L +I+ ++  N F+ YV Y+QNQ +Q     +L    A  + +  ++ QP C  L L+SFLLLPMQR+ R+ LLL A+   A P+     +    A+  IEK+I KC   K  +++++R++EI R L++K   K +  +   L+ EG+++       + +    +       K       L S+YLL+TK  +      V+D CS S I VE      N  I  F
Sbjct:  236 ERSKNQSSASKPRRQTQEVQNFVNEVAGTGPNRVQWSEMPQVISADLARDLPDYQKKLQEALFEVITSEASYYRTLHILIEKFYKAPCM---QPDSKTSVITAIEKRHLFSNISEIFFTSETFLRDMELYFIQNPLIPQLCEIIYEHTENHFENYVKYVQNQMYQLRTLTKLLSSPAFVEAVRSIQQQPSCGFLDLNSFLLLPMQRVTRLRLLLTAILHYA-PKNGVTYQSGLVALASIEKLISKCDSEKARMEQKERLVEICRRLEYKYDAKSLATESRTLVKEGDLRLLTMTNVQGSGFHRRFSSIRKSKATIATLFLFSDYLLITK-KRSNQHLLVEDSCSLSYIHVEAHNALPNCFIHHF 594

[Close]

BLAST of Neuronal guanine nucleotide exchange factor vs. TrEMBL
Match: A0A3Q0KCF1 (Putative guanine-nucleotide-exchange-factor OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 140.584 bits (353), Expect = 8.233e-31
Identity = 124/364 (34.07%), Postives = 193/364 (53.02%), Query Frame = 2

Query:  593 DRSRN--SSRKPGKICQELKENRN---------LKWIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNELKKEIATAKIIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDFK-PGKKIKEQLGKLIHEGEVK-------RSNKNPXXXXXXXXXXXXXXWFILTSEYLLMTKLSKKEVTYNVDDYCSSSEIFVEYETIEENGNIFQF 1627
            +RS+N  S+ KP +  QE++   N         ++W E  QV S  LA+++   + K QE+ FE+I+SEASY R+L +LI+KFY AP M   + +    +I   +K HLFSNI +I+  S  FL D+E  F ++  I  L +I+ ++  N F+ YV Y+QNQ +Q     +L    A  + +  ++ QP C  L L+SFLLLPMQR+ R+ LLL A+   A P+     +    A+  IEK+I KC   K  +++++R++EI R L++K   K +  +   L+ EG+++       + +    +       K       L S+YLL+TK    +    V+D CS S I VE      N  I  F
Sbjct:  312 ERSKNQSSASKPRRQTQEVQNFVNEVAGTGPNRVQWSEMPQVISADLARDLPDYQKKLQEALFEVITSEASYYRTLHILIEKFYKAPCM---QPDSKTSVITAIEKRHLFSNISEIFFTSETFLRDMELYFIQNPLIPQLCEIIYEHTENHFENYVKYVQNQMYQLRTLTKLLSSPAFVEAVRSIQQQPSCGFLDLNSFLLLPMQRVTRLRLLLTAILHYA-PKNGVTYQSGLVALASIEKLISKCDSEKARMEQKERLVEICRRLEYKYDAKSLATESRTLVKEGDLRLLTMTNVQGSGFHRRFSSIRKSKATIATLFLFSDYLLITKKRSNQHLL-VEDSCSLSYIHVEAHNALPNCFIHHF 670

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BLAST of Neuronal guanine nucleotide exchange factor vs. TrEMBL
Match: G4V979 (Putative guanine-nucleotide-exchange-factor OS=Schistosoma mansoni OX=6183 GN=Smp_012580 PE=4 SV=1)

HSP 1 Score: 140.584 bits (353), Expect = 8.821e-31
Identity = 124/364 (34.07%), Postives = 193/364 (53.02%), Query Frame = 2

Query:  593 DRSRN--SSRKPGKICQELKENRN---------LKWIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNELKKEIATAKIIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDFK-PGKKIKEQLGKLIHEGEVK-------RSNKNPXXXXXXXXXXXXXXWFILTSEYLLMTKLSKKEVTYNVDDYCSSSEIFVEYETIEENGNIFQF 1627
            +RS+N  S+ KP +  QE++   N         ++W E  QV S  LA+++   + K QE+ FE+I+SEASY R+L +LI+KFY AP M   + +    +I   +K HLFSNI +I+  S  FL D+E  F ++  I  L +I+ ++  N F+ YV Y+QNQ +Q     +L    A  + +  ++ QP C  L L+SFLLLPMQR+ R+ LLL A+   A P+     +    A+  IEK+I KC   K  +++++R++EI R L++K   K +  +   L+ EG+++       + +    +       K       L S+YLL+TK    +    V+D CS S I VE      N  I  F
Sbjct:  316 ERSKNQSSASKPRRQTQEVQNFVNEVAGTGPNRVQWSEMPQVISADLARDLPDYQKKLQEALFEVITSEASYYRTLHILIEKFYKAPCM---QPDSKTSVITAIEKRHLFSNISEIFFTSETFLRDMELYFIQNPLIPQLCEIIYEHTENHFENYVKYVQNQMYQLRTLTKLLSSPAFVEAVRSIQQQPSCGFLDLNSFLLLPMQRVTRLRLLLTAILHYA-PKNGVTYQSGLVALASIEKLISKCDSEKARMEQKERLVEICRRLEYKYDAKSLATESRTLVKEGDLRLLTMTNVQGSGFHRRFSSIRKSKATIATLFLFSDYLLITKKRSNQHLL-VEDSCSLSYIHVEAHNALPNCFIHHF 674

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BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Cavefish
Match: si:dkey-38p12.3 (rho guanine nucleotide exchange factor 15-like [Source:NCBI gene;Acc:103030780])

HSP 1 Score: 106.301 bits (264), Expect = 3.153e-23
Identity = 84/244 (34.43%), Postives = 134/244 (54.92%), Query Frame = 2

Query:  653 RNLKWIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNEL-KKEIATAKIIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVD------KAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDF 1363
            +N  W +   VK  G+ + +  EE K+QES FE+++SE SY RSL VL + F        +E+  +   +    K+ LFSNIL+I  +S KFL DLE R  ES  ++D+ DI++ +A + F  Y+ Y++NQ +Q + Y+ L +     A +I  L+  P C  L   SFLLLP QR+ RI +L++ +        K  +E  D      KA+  + KII +C+     + + + ++EI + L+F
Sbjct:  548 QNTLWQDLPSVKESGILQKLTPEECKYQESMFEVMTSEVSYLRSLRVLTEHF--------LESRELNDTLIVLDKKTLFSNILRIREVSEKFLKDLENRLDESLVVSDICDIISYHAQHNFPAYIDYVRNQIYQDKTYSTLMQTNTQFATVISRLQESPRCQRLPFMSFLLLPFQRITRIKILVENIL-------KRTVEGTDKEESASKALSAVSKIIEECNSQVGKMKQMEELIEINKMLEF 776

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BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Cavefish
Match: arhgef16 (rho guanine nucleotide exchange factor 16 [Source:NCBI gene;Acc:103040535])

HSP 1 Score: 100.523 bits (249), Expect = 1.152e-21
Identity = 103/360 (28.61%), Postives = 179/360 (49.72%), Query Frame = 2

Query:  659 LKWIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNE-LKKEIATAKIIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDF---KPGKKIKEQLGKLIHEGEVKRSNKNPXXXXXXXXXXXXXXWFILTSEYLLMTKLSKKEVTYNVDDYCSSSEIFVEYETIEENGNIFQF-KLQINRNSDV-CDVYLIQTKNKESHKKWMNLL 1720
            + W +   V+  G+ + +  EE K QE  FEI++SE SY  SLS+L+  F          ++ ++  +   +  HLFSNI  I  +S +F  +LERR      I D+SDIV  YA N F  Y+ Y  N+ FQ     + L    A  ++++++ES PEC  L + SFL+LPMQR  R+ LL+  +     P+Q         A++ I K++  C++    ++  ++M  I + ++F   KP   +      L+ +GE+  + +        ++   K +W  + ++ L++TK  K E +Y V DY +   +    E +EE  +   + +L +  NS+  C+     ++NK    +W+  L
Sbjct:  235 VTWSQLPVVQEMGILETISPEERKRQEVIFEIMTSEYSYLHSLSILVRHFK--------ASDDLRKAMTATEHHHLFSNISVIQAVSKRFFEELERRHQLDPVIKDISDIVQDYAANHFKPYIVYCSNETFQQRTLQKLLASNTAFKEVLKKIESSPECGGLPMISFLILPMQRATRLPLLMDTI-CQKTPKQTTNYYAARWALKEISKLVKSCNDGARRMERTEQMYTIQKQMEFGRIKPFPLVSASRW-LLKKGELAINLEE--LGLFWKAFSHKSYWLFVFNDVLIVTK-RKSEESYVVCDYATLENV----EVVEEQADSKHYLRLTMKPNSEGRCEQMAFVSENKLDRARWVTAL 577

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Query:  659 LKWIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNE-LKKEIATAKIIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDF---KPGKKIKEQLGKLIHEGEVKRSNKNPXXXXXXXXXXXXXXWFILTSEYLLMTKLSKKEVTYNVDDYCSSSEIFVEYETIEENGNIFQF-KLQINRNSDV-CDVYLIQTKNKESHKKWMNLL 1720
            + W +   V+  G+ + +  EE K QE  FEI++SE SY  SLS+L+  F          ++ ++  +   +  HLFSNI  I  +S +F  +LERR      I D+SDIV  YA N F  Y+ Y  N+ FQ     + L    A  ++++++ES PEC  L + SFL+LPMQR  R+ LL+  +     P+Q         A++ I K++  C++    ++  ++M  I + ++F   KP   +      L+ +GE+  + +        ++   K +W  + ++ L++TK  K E +Y V DY +   +    E +EE  +   + +L +  NS+  C+     ++NK    +W+  L
Sbjct:  235 VTWSQLPVVQEMGILETISPEERKRQEVIFEIMTSEYSYLHSLSILVRHFK--------ASDDLRKAMTATEHHHLFSNISVIQAVSKRFFEELERRHQLDPVIKDISDIVQDYAANHFKPYIVYCSNETFQQRTLQKLLASNTAFKEVLKKIESSPECGGLPMISFLILPMQRATRLPLLMDTI-CQKTPKQTTNYYAARWALKEISKLVKSCNDGARRMERTEQMYTIQKQMEFGRIKPFPLVSASRW-LLKKGELAINLEE--LGLFWKAFSHKSYWLFVFNDVLIVTK-RKSEESYVVCDYATLENV----EVVEEQADSKHYLRLTMKPNSEGRCEQMAFVSENKLDRARWVTAL 577

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BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Cavefish
Match: ngef (neuronal guanine nucleotide exchange factor [Source:ZFIN;Acc:ZDB-GENE-130530-794])

HSP 1 Score: 98.2117 bits (243), Expect = 5.071e-21
Identity = 110/352 (31.25%), Postives = 182/352 (51.70%), Query Frame = 2

Query:  683 VKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNELKKEIATAKI-IEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDFKP-GKKIKEQLGKLIHEGEVKRSNKNPXXXXXXXXXXXXXXWFILTSEYLLMTKLSKKEVTYNVDDYCSSSEIFVEYETIEENGNI--FQFKLQINRNSDVCDV-YLIQTKNKESHKKWMNLLS 1723
            V++ GL   +   EI  QE+ FE+++SEASY +SL +L + F   P   L+ T      +       LFSNI  I   S +FL DLE R  ES  I+D+ DIV  +AVN F V++ Y+ NQ +Q + Y  + +E A  +  +  LE+QP+   LS  SFL+LP QR+ R+ LL++ +    +   +  I  + KA Q +E+I+ +C+E    +   + ++ I + L+FK     +      L+ +GEV + +   S + M     +   +  L +  LL+TK S     + V D CS S   +  E +E+ G +  F F L++  N +   V Y+++T +     +W+  L+
Sbjct:  119 VQNSGLLSGLPHREIILQEAMFELVTSEASYYKSLELLENHFLQNPL--LINT------LSQSDMHFLFSNIADIMKASERFLMDLEHRIEESLLISDVCDIVFHHAVNYFHVFISYVINQVYQEKNYRRILQENALFRENMALLENQPKVKGLSFTSFLILPFQRITRLKLLVQNILKKVEENSEREINAI-KAHQELERIVKECNEGARKMSRTEELISIEKTLEFKSKSVPVISHSRWLLKKGEVLQMSGPKSTRTMKSRKLYHPIYLFLFNNLLLITKRSSSGEKFQVLDSCSRS--MLRTEDLEDQGQMLAFVFVLKLLENQEDRPVSYMLKTTSMSEKLRWICALT 459

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BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Cavefish
Match: ARHGEF26 (Rho guanine nucleotide exchange factor 26 [Source:NCBI gene;Acc:103044275])

HSP 1 Score: 92.0485 bits (227), Expect = 8.436e-19
Identity = 89/315 (28.25%), Postives = 150/315 (47.62%), Query Frame = 2

Query:  665 WIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNE-LKKEIATAKIIEELESQPEC-----CXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDF--KPGKKIKEQLGKLIHEGEVKRSNKNPXXXXXXXXXXXXXXWFILTSEYLLMTKLSKKEVTYNVDDYCSSSEIFV 1585
            W +   VK    AK + +EE K QE+ FE+ISSE SY  SL +LI  F ++ ++S   T             HLFSNI+ +   S KF  +LE R  ++  I D+SDIV ++A + F+ YV Y  N+ +Q       L K  +  +++  +E+  +C     CS  +     +    LL   +  K  + + Q       E   KA+  + K++ KC+E    ++  + M  I   L+F  KP   +      ++  GE+   ++       S+ M  ++ +F L ++ L++T+  K E +Y V DY    +I+V
Sbjct:  444 WSQLSVVKKSEAAKKLSQEERKRQEAIFEVISSEHSYLHSLMILIRLFKDSQELSETMTK--------TDHHHLFSNIVDVCETSKKFFKELEDRHQQNIVIDDISDIVIRHAQSNFEPYVTYCSNEVYQQRTLQRLLSKNPSFKEVLNRIETHSDCRNLPMCSFLILPMQRVTRLPLLVDTICQKTPKDSPQ------YEECKKALHCVSKLVRKCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRW-MVKRGELTAYSEE-KNSIFSKRMSRQQVYFFLFNDVLIVTR-KKSEESYTVIDYALRDQIWV 741

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BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000490.1 (pep scaffold:Pmarinus_7.0:GL477825:44699:67115:1 gene:ENSPMAG00000000430.1 transcript:ENSPMAT00000000490.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 85.8853 bits (211), Expect = 6.095e-18
Identity = 52/182 (28.57%), Postives = 101/182 (55.49%), Query Frame = 2

Query:  590 DDRSRNSSRKPGKICQELKENRNLKWIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNELKKEIAT-AKIIEELESQPEC 1132
            + R R+  R+      +L++ R L W     V + G+  ++  +  K QE+ FE+++SEASY +S+S++ D F  + +++          +    K+ L+S+I  +  ++  F+A+L  R      I+D+ DIV KYA ++F VY+PY+ N R+Q + + EL++  +  +  ++ L+  P+C
Sbjct:   52 ESRGRDEERRESVALLQLQQQRML-WQHLPHVIASGVLASLSGDAKKQQEAMFEVLTSEASYLKSISIVTDFFMTSEELN--------QTLNMESKKALYSSIADVKKVTESFIAELGDRIDSDILISDICDIVYKYARDDFKVYIPYLTNNRYQEKKFIELRESNSQFSAAVQRLQEMPQC 224

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BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Yeast
Match: ROM2 (Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p; ROM2 has a paralog, ROM1, that arose from the whole genome duplication [Source:SGD;Acc:S000004363])

HSP 1 Score: 54.299 bits (129), Expect = 5.953e-8
Identity = 35/115 (30.43%), Postives = 66/115 (57.39%), Query Frame = 2

Query:  707 NMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRF 1051
            N+ K+EIK QE+ +E+  +E ++ +SL +  D F      +L ETN I   I+    +H+F++I  IY+++ +FL  L  R   S  +  + DIV ++ +  F+ +V Y+ ++ +
Sbjct:  652 NLPKKEIKRQEAIYEVYITEKNFVKSLEITRDTFMK----TLAETNIISADIRKNFIKHVFAHINDIYSVNRRFLKALTDRQRSSPVVRGIGDIVLRF-IPFFEPFVSYVASRPY 761

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BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Yeast
Match: ROM1 (Guanine nucleotide exchange factor (GEF) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP; ROM1 has a paralog, ROM2, that arose from the whole genome duplication [Source:SGD;Acc:S000003302])

HSP 1 Score: 52.373 bits (124), Expect = 2.201e-7
Identity = 34/120 (28.33%), Postives = 71/120 (59.17%), Query Frame = 2

Query:  692 KGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRF 1051
            K + +++ K++IK QE+ +E+ ++E  + +SL ++ D F       L+ETN I   ++    +H+F++I +IY+++ +FL  L +R   S     ++DI  +Y +  FD ++ YI ++ +
Sbjct:  452 KSVWESLSKQQIKRQEAIYELFTTEKKFVKSLEIIRDTFMK----KLLETNIIPSDVRINFVKHVFAHINEIYSVNREFLKALAQRQSLSPICPGIADIFLQY-LPFFDPFLSYIASRPY 566

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BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Nematostella
Match: EDO39595 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S9L2])

HSP 1 Score: 92.4337 bits (228), Expect = 8.466e-20
Identity = 94/361 (26.04%), Postives = 175/361 (48.48%), Query Frame = 2

Query:  659 LKWIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNELKKEIATAKIIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELV--DKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDF--KPGKKIKEQLGKLIHEGEVKRSN---KNPXXXXXXXXXXXXXXWFILTSEYLLMTKLSKKEVTYNVDDYCSS--SEIFVEYETIEENGNIFQFKLQINRNSDVCDVYLIQTKNKESHKKWMN 1714
            + W E  +V   G+ + +   E K QE+ FE+I+SEASY +SL++L   F ++P++   + +  + +++  Q+  LF N+  +   S KFL  L +R  +S  I+ +SDI+ ++A   FD+Y+ Y  +Q +Q     EL K     + +E +    +C +    SF    +  + RI  L   V       ++   E V  DKA++ I K++H C+E    ++  + ++ +   ++F  KP   +      L+  GEV       K+P    + + +K K  +  L ++ LLM K  K ++ Y V DY +   +++ V  E   +   +    L  N N    D +LI  +++    +W++
Sbjct:    1 MLWCELPEVMKSGVLETIDPTERKRQEAMFEVITSEASYLKSLNILGSHFMDSPEL---QADTAQSVVEKSQQRVLFGNVKGVLEASEKFLTALRQRQRKSYVISTISDIIEEHATQYFDIYIKYCSHQVYQDRILKELGK---NPRFVEAVRRLEQCSTAQCLSFQSFLVLPMQRITRLPLLVDAICHRCEEGSDEFVRTDKALKSINKVVHDCNEGARKMERMEELIALQPLIEFAVKPVALVSSNRW-LLRRGEVLLVTEEFKSP----LRKKIKTKPVYMFLFNDLLLMCK-KKSDIKYRVLDYANRNMTKVEVANEPSIQMKYLLSLILLENSNGKTKD-FLICAESETDKTRWLD 348

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BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Medaka
Match: arhgef16 (rho guanine nucleotide exchange factor 16 [Source:NCBI gene;Acc:101175237])

HSP 1 Score: 107.842 bits (268), Expect = 6.179e-24
Identity = 114/386 (29.53%), Postives = 187/386 (48.45%), Query Frame = 2

Query:  533 SNNNQEALNDIDLVDCIFKDDRSRNSSRKPGKICQELKENRNLKWIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNE-LKKEIATAKIIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDF---KPGKKIKEQLGKLIHEGEVKRSNKNPXXXXXXXXXXXXXXWFILTSEYLLMTKLSKKEVTYNVDDYCSSSEIFVEYETIEENGNI--------FQFKLQINRNSD 1654
            S N  E L+D  +V+   +D      + KP +          L W +  QVK+  +   +  +E K QE+ FEII SE SY  SL +L+  F N+  +S          + P +  HLFSNI  I  +S +F  DLERR  E   I D+SDI+  +A + F+ Y+ Y  N+ FQ   + + L    A  + +++LES  EC  L + SFL+LPMQR+ R+ LLL  +     P+          A+  + K++  C++    ++  ++M  I + +DF   KP   +      L   GE+   N +  +  + ++   + ++  L ++ L++TK  K E  + V DY +   + VEY  +E +G +          FKL + +NSD
Sbjct:  226 STNQDELLDDFVVVETPVEDQGIVVKNYKPAQ----------LTWSQLPQVKNSDILSRITPQERKRQEAIFEIICSEHSYLHSLGILVRHFKNSKTLS--------KTMAPTEHHHLFSNISVILKVSQRFFEDLERRHQEDVVIRDISDIIQNHAAHHFEPYIAYCSNETFQQRTHQKLLNTNSAFKEALKQLESSSECGGLPMFSFLILPMQRVTRLPLLLDTI-CQKTPENTAEYFAAVWALHAMSKLVTSCNDGARRMERTEQMYTIQKQMDFGKIKPFPLVSSSRW-LKKRGEL---NISAEELSIWKAFTNRSYYLFLFNDVLIVTK-KKTEEIFVVLDYATLENVEVEY-VMETDGQMSSPTKSTPLTFKLLMTKNSD 586

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Query:  533 SNNNQEALNDIDLVDCIFKDDRSRNSSRKPGKICQELKENRNLKWIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNE-LKKEIATAKIIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDF---KPGKKIKEQLGKLIHEGEVKRSNKNPXXXXXXXXXXXXXXWFILTSEYLLMTKLSKKEVTYNVDDYCSSSEIFVEYETIEENGNI--------FQFKLQINRNSD 1654
            S N  E L+D  +V+   +D      + KP +          L W +  QVK+  +   +  +E K QE+ FEII SE SY  SL +L+  F N+  +S          + P +  HLFSNI  I  +S +F  DLERR  E   I D+SDI+  +A + F+ Y+ Y  N+ FQ   + + L    A  + +++LES  EC  L + SFL+LPMQR+ R+ LLL  +     P+          A+  + K++  C++    ++  ++M  I + +DF   KP   +      L   GE+   N +  +  + ++   + ++  L ++ L++TK  K E  + V DY +   + VEY  +E +G +          FKL + +NSD
Sbjct:  226 STNQDELLDDFVVVETPVEDQGIVVKNYKPAQ----------LTWSQLPQVKNSDILSRITPQERKRQEAIFEIICSEHSYLHSLGILVRHFKNSKTLS--------KTMAPTEHHHLFSNISVILKVSQRFFEDLERRHQEDVVIRDISDIIQNHAAHHFEPYIAYCSNETFQQRTHQKLLNTNSAFKEALKQLESSSECGGLPMFSFLILPMQRVTRLPLLLDTI-CQKTPENTAEYFAAVWALHAMSKLVTSCNDGARRMERTEQMYTIQKQMDFGKIKPFPLVSSSRW-LKKRGEL---NISAEELSIWKAFTNRSYYLFLFNDVLIVTK-KKTEEIFVVLDYATLENVEVEY-VMETDGQMSSPTKSTPLTFKLLMTKNSD 586

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BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Medaka
Match: si:dkey-38p12.3 (ephexin-1 [Source:NCBI gene;Acc:101161585])

HSP 1 Score: 99.3673 bits (246), Expect = 4.385e-21
Identity = 60/182 (32.97%), Postives = 98/182 (53.85%), Query Frame = 2

Query:  590 DDRSRNSSRKPGKICQELKENRNLKWIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNELKKEIAT-AKIIEELESQPEC 1132
            D  +R SS   G     +  +++  W +  QV+  G+ + +  E+ K+QES FE+++SE SY RSL VL + F    ++      G   II+    + LFSNIL++  +S +FL DLE R  +     D+ DI+  ++ + F  Y+ Y++NQ +Q + Y  L K  A  A +I  L+  P+C
Sbjct:  473 DWAARPSSNGGGPRSSPIPADKSTLWQDLPQVRESGVLETLTPEQCKYQESMFEVLTSETSYLRSLHVLTEHFLENREL------GEALIIR--DTKTLFSNILRVREVSERFLKDLEDRVFQDIVFPDICDIIHYHSQHNFPAYIDYVRNQIYQEKTYAVLMKTNAQFAAVIARLQESPQC 646

[Close]

BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Medaka
Match: ARHGEF26 (Rho guanine nucleotide exchange factor 26 [Source:NCBI gene;Acc:101154796])

HSP 1 Score: 97.8265 bits (242), Expect = 1.199e-20
Identity = 96/310 (30.97%), Postives = 160/310 (51.61%), Query Frame = 2

Query:  665 WIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNELKKEIATAK-IIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDF--KPGKKIKEQLGKLIHEGEVKRSNKNPXXXXXXXXXXXXXXWFILTSEYLLMTKLSKKEVTYNVDDYCSSSEIFV 1585
            W +   VK  GL++ + +EE K QE+ FE+ISSE SY  SL +LI  F ++ ++        +  +   Q  HLFSNI  +   S +F  +LE R  ++  I+D+SDIV K+A + FD ++ Y  N+ +Q     +L     T K ++ ++E+ P+C +L + SFL+LPMQR+ R+ LL+  +     P+     E    A+Q I K++ KC+E    ++  + +  I   L+F  KP   I      ++  GEV    +        +    +  + +L ++ L++T+  K E +Y V DY    EI V
Sbjct:  488 WSQLTVVKKSGLSEKLSQEERKRQEAIFELISSEHSYFHSLEILIRLFKDSAEL--------RETMSKMQHHHLFSNISDVCEASKEFFKELEERHEKNIVISDISDIVCKHAQSNFDPFITYCSNEVYQQRTLQKLLSTNPTFKEVLTKIEAHPDCRNLPMISFLILPMQRITRLPLLMDTI-CQKTPKTSRQYEDCKTALQEISKVVRKCNEGARTMERTEMLCTINSQLEFKIKPFPLISSSRW-MVKRGEVTSLVEG----VFLKRTTRQHLYLLLFNDVLIITR-KKSEDSYTVVDYALRDEISV 782

[Close]

BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Medaka
Match: ngef (neuronal guanine nucleotide exchange factor [Source:NCBI gene;Acc:101175182])

HSP 1 Score: 90.1225 bits (222), Expect = 1.418e-18
Identity = 79/235 (33.62%), Postives = 128/235 (54.47%), Query Frame = 2

Query:  665 WIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNELKKE-IATAKIIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDFK 1366
            W   E V+S GL   + + EI+ QE+ FE+++SEASY +SL +L   F   P+  L+ T      +       LFSNI ++   S +FL DLE R  E+  I+D+ DIV  +A   F V++ Y+ NQ +Q + Y  + +E  A  + + ELE       LS  SFL+LP QR+ R+ LL++ +   A+   +     + KA Q +E+I+ +C+E    +   + ++ I + L+FK
Sbjct:   56 WQNLEAVQSSGLLSRLSQNEIRMQEAMFELVTSEASYYKSLEILETHFLRNPR--LINT------LSQSDTHFLFSNIEEVMEASERFLMDLEHRIEEAILISDVCDIVFHHAEKHFKVFITYVINQVYQEKTYRRILEENQAFRETMAELEKHSCVRGLSFTSFLILPFQRITRLKLLVQNILKTAEEHSERETNAI-KAHQQLEQIVQECNEGVRKMSRTEELISIEKTLEFK 281

[Close]

BLAST of Neuronal guanine nucleotide exchange factor vs. Planmine SMEST
Match: SMESG000003812.1 (SMESG000003812.1)

HSP 1 Score: 1077.39 bits (2785), Expect = 0.000e+0
Identity = 574/577 (99.48%), Postives = 574/577 (99.48%), Query Frame = 2

Query:    2 MSTWVKQMRLKYEKLKLDRSNANSKKPVSPKDKTTSVRSNCERSQKKLESENGSFDSKNNVSQNSISNLGLKPSEIVNEHNICIYSDPESDSLYGSFRKRENVSSLNPGKSSENDIILRLKTGESEFQTIKRYESILRPPLFQHINVSKRRKENFEDKPRKTSLVATLIDAFNHQKISNNNQEALNDIDLVDCIFKDDRSRNSSRKPGKICQELKENRNLKWIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNELKKEIATAKIIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDFKPGKKIKEQLGKLIHEGEVKRSNKNPXXXXXXXXXXXXXXWFILTSEYLLMTKLSK-KEVTYNVDDYCSSSEIFVEYETIEENGNIFQFKLQINRNSDVCDVYLIQTKNKESHKKWMNLLSNS 1729
            MSTWVKQMRLKYEKLKLDRSNANSKKPVSPKDKT SVRSNCERSQKKLESENGSFDSKNNVSQNSISNLGLKPSEIVNE NICIYSDPESDSLYGSFRKRENVSSLNPGKSSENDIILRLKTGESEFQTIKRYESILRPPLFQHINVSKRRKENFEDKPRKTSLVATLIDAFNHQKISNNNQEALNDIDLVDCIFKDDRSRNSSRKPGKICQELKENRNLKWIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNELKKEIATAKIIEELESQPECCSLSLDSFLLLPMQRLLRILLLLKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDFKPGKKIKEQLGKLIHEGEVKRSNKNPSKKFMSESMKFKEFWFILTSEYLLMTKLSK KEVTYNVDDYCSSSEIFVEYETIEENGNIFQFKLQINRNSDVCDVYLIQTKNKESHKKWMNLLSNS
Sbjct:    1 MSTWVKQMRLKYEKLKLDRSNANSKKPVSPKDKTASVRSNCERSQKKLESENGSFDSKNNVSQNSISNLGLKPSEIVNEDNICIYSDPESDSLYGSFRKRENVSSLNPGKSSENDIILRLKTGESEFQTIKRYESILRPPLFQHINVSKRRKENFEDKPRKTSLVATLIDAFNHQKISNNNQEALNDIDLVDCIFKDDRSRNSSRKPGKICQELKENRNLKWIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRFQSEAYNELKKEIATAKIIEELESQPECCSLSLDSFLLLPMQRLLRILLLLKAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDFKPGKKIKEQLGKLIHEGEVKRSNKNPSKKFMSESMKFKEFWFILTSEYLLMTKLSKGKEVTYNVDDYCSSSEIFVEYETIEENGNIFQFKLQINRNSDVCDVYLIQTKNKESHKKWMNLLSNS 577

[Close]

BLAST of Neuronal guanine nucleotide exchange factor vs. Planmine SMEST
Match: SMESG000044434.1 (SMESG000044434.1)

HSP 1 Score: 131.724 bits (330), Expect = 1.298e-31
Identity = 117/346 (33.82%), Postives = 192/346 (55.49%), Query Frame = 2

Query:  581 IFKDDRSRNSSRKPGKICQELKENRNLKWIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCES-AKITDLSDIVTKYAVN-EF-DVYVPYIQNQRFQSEAYNELKKEIATAKIIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVRTNAQPQQ-------KHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDFK-PGKKIKEQLGKLIHEGEVKRSNK--NPXXXXXXXXXXXXXXWFILTSEYLLMTKLSKKEVTYNVDDYCSSSEI 1579
            I KD +      K  K  ++ K +  L W   ++VKS G+   MKKEEI  QE+ FE+I+SEASYN SL  LI+ +Y   +  L+  N    II P +K HLFSNIL I T+S K L DLE R+ +   K+ DL+DI+ K+A + +F   Y+ Y+ NQ +Q  A   L ++    + +  ++S P+CC LSLDSFL LPMQRL R+ LL + +    +  +       K V+E   KA++ + +++  C ENK  ++++ R++++ + L+F+   + +      LI +GEV+ +    + +        +   F+ I+ SE ++  K  K +  + V ++C  S++
Sbjct:  375 ISKDQQEEALIEKQIKAIKDSKASNRLYWSNMDEVKSSGVLSAMKKEEIHLQEAIFEVITSEASYNISLDTLIEYYY---KNELLNANKHDSIINPVEKHHLFSNILLIKTVSLKLLKDLESRWSQQKPKMVDLADIILKHAEDKDFQQQYIFYLTNQSYQINALKALLQKEVFKQALYTIQSNPQCCKLSLDSFLALPMQRLTRLKLLTEVISKLMKQSKDLYETIPKEVVENNRKALEKLRELLSACEENKFKMEQKARLIDLCKFLEFRNSSRHVAIGSMDLIKDGEVRAAANQISSNALKKLSKKRQPTFYLIILSELVIFAK-KKSQTKFVVLEHCPRSKV 716

[Close]

BLAST of Neuronal guanine nucleotide exchange factor vs. Planmine SMEST
Match: SMESG000056271.1 (SMESG000056271.1)

HSP 1 Score: 109.768 bits (273), Expect = 1.317e-24
Identity = 87/246 (35.37%), Postives = 144/246 (58.54%), Query Frame = 2

Query:  665 WIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKI-TDLSDIVTKYAV-NEFDVYVPYIQNQRFQSEAYNELKKEIATAKIIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVR--TNAQPQQKHVIELVDK----AIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDFKPGKK 1378
            W +  +V   G+ K + K EI+ QE+ FEII+SEASY RSL +L   F+++   S+ E    + I+ P  K H+FSN++ I   S   L DLE+R+ E   + +D+ DIV  + + ++F  YV Y++NQ++Q++A   L +     + + +LES  EC  LSLDS+L+LPMQRL R+ LL++AV    N +     + E V      A+  I+K+++  +  K ++D++  ++ +I  + F P  K
Sbjct:  287 WSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDK--ETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRLSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKKLLNTSNTEKGFMDQKSALISLINRIYFPPNVK 530

[Close]

BLAST of Neuronal guanine nucleotide exchange factor vs. Planmine SMEST
Match: SMESG000056271.1 (SMESG000056271.1)

HSP 1 Score: 109.768 bits (273), Expect = 1.569e-24
Identity = 87/246 (35.37%), Postives = 144/246 (58.54%), Query Frame = 2

Query:  665 WIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKI-TDLSDIVTKYAV-NEFDVYVPYIQNQRFQSEAYNELKKEIATAKIIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVR--TNAQPQQKHVIELVDK----AIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDFKPGKK 1378
            W +  +V   G+ K + K EI+ QE+ FEII+SEASY RSL +L   F+++   S+ E    + I+ P  K H+FSN++ I   S   L DLE+R+ E   + +D+ DIV  + + ++F  YV Y++NQ++Q++A   L +     + + +LES  EC  LSLDS+L+LPMQRL R+ LL++AV    N +     + E V      A+  I+K+++  +  K ++D++  ++ +I  + F P  K
Sbjct:  287 WSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDK--ETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRLSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKKLLNTSNTEKGFMDQKSALISLINRIYFPPNVK 530

[Close]

BLAST of Neuronal guanine nucleotide exchange factor vs. Planmine SMEST
Match: SMESG000056271.1 (SMESG000056271.1)

HSP 1 Score: 93.2041 bits (230), Expect = 1.033e-19
Identity = 79/223 (35.43%), Postives = 132/223 (59.19%), Query Frame = 2

Query:  734 QESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKI-TDLSDIVTKYAV-NEFDVYVPYIQNQRFQSEAYNELKKEIATAKIIEELESQPECCXXXXXXXXXXXXXXXXXXXXXXKAVR--TNAQPQQKHVIELVDK----AIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDFKPGKK 1378
            Q++ FEII+SEASY RSL +L   F+++   S+ E    + I+ P  K H+FSN++ I   S   L DLE+R+ E   + +D+ DIV  + + ++F  YV Y++NQ++Q++A   L +     + + +LES  EC  LSLDS+L+LPMQRL R+ LL++AV    N +     + E V      A+  I+K+++  +  K ++D++  ++ +I  + F P  K
Sbjct:    5 QQAMFEIITSEASYYRSLMILTKHFFSSELFSISEDK--ETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRLSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKKLLNTSNTEKGFMDQKSALISLINRIYFPPNVK 225

The following BLAST results are available for this feature:

BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Human
BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Celegans
BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Fly
BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Zebrafish
BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Xenopus
BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Mouse
BLAST of Neuronal guanine nucleotide exchange factor vs. UniProt/SwissProt
BLAST of Neuronal guanine nucleotide exchange factor vs. TrEMBL
BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Cavefish
BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Sea Lamprey
BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Yeast
BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Nematostella
BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Medaka
BLAST of Neuronal guanine nucleotide exchange factor vs. Planmine SMEST

BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
NGEF	2.214e-29	28.97	neuronal guanine nucleotide exchange factor [Sourc...	[more]
NGEF	4.311e-29	28.97	neuronal guanine nucleotide exchange factor [Sourc...	[more]
ARHGEF15	7.735e-25	34.45	Rho guanine nucleotide exchange factor 15 [Source:...	[more]
ARHGEF15	9.177e-25	33.86	Rho guanine nucleotide exchange factor 15 [Source:...	[more]
ARHGEF15	9.177e-25	33.86	Rho guanine nucleotide exchange factor 15 [Source:...	[more]

BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 4


Match Name	E-value	Identity	Description
ephx-1	2.105e-20	35.03	EPHeXin (Eph-interacting GEF) homolog [Source:Uni...	[more]
ephx-1	2.890e-20	35.03	EPHeXin (Eph-interacting GEF) homolog [Source:Uni...	[more]
ephx-1	4.660e-20	35.03	EPHeXin (Eph-interacting GEF) homolog [Source:Uni...	[more]
ephx-1	5.267e-20	35.03	EPHeXin (Eph-interacting GEF) homolog [Source:Uni...	[more]

BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Exn	1.170e-14	29.30	gene:FBgn0261547 transcript:FBtr0302647	[more]
Exn	1.170e-14	29.30	gene:FBgn0261547 transcript:FBtr0302648	[more]
Exn	1.170e-14	29.30	gene:FBgn0261547 transcript:FBtr0302649	[more]
Exn	3.496e-14	29.30	gene:FBgn0261547 transcript:FBtr0302651	[more]
Exn	3.496e-14	29.30	gene:FBgn0261547 transcript:FBtr0302650	[more]

BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
arhgef15	1.741e-22	36.94	Rho guanine nucleotide exchange factor (GEF) 15 [S...	[more]
ngef	2.769e-22	29.01	neuronal guanine nucleotide exchange factor [Sourc...	[more]
ngef	2.981e-22	29.01	neuronal guanine nucleotide exchange factor [Sourc...	[more]
arhgef15	4.040e-22	36.94	Rho guanine nucleotide exchange factor (GEF) 15 [S...	[more]
si:dkey-38p12.3	1.602e-19	32.20	si:dkey-38p12.3 [Source:ZFIN;Acc:ZDB-GENE-060810-1...	[more]

BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ARHGEF26	6.973e-25	32.59	Rho guanine nucleotide exchange factor 26 [Source:...	[more]
ARHGEF26	8.022e-25	32.59	Rho guanine nucleotide exchange factor 26 [Source:...	[more]
ARHGEF26	8.231e-25	32.59	Rho guanine nucleotide exchange factor 26 [Source:...	[more]
NGEF	1.975e-23	27.11	neuronal guanine nucleotide exchange factor [Sourc...	[more]
NGEF	2.349e-23	27.11	neuronal guanine nucleotide exchange factor [Sourc...	[more]

BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Ngef	9.389e-29	28.69	neuronal guanine nucleotide exchange factor [Sourc...	[more]
Ngef	2.112e-28	28.69	neuronal guanine nucleotide exchange factor [Sourc...	[more]
Arhgef15	1.338e-25	34.30	Rho guanine nucleotide exchange factor (GEF) 15 [S...	[more]
Arhgef15	1.338e-25	34.30	Rho guanine nucleotide exchange factor (GEF) 15 [S...	[more]
Arhgef26	1.530e-23	28.50	Rho guanine nucleotide exchange factor (GEF) 26 [S...	[more]

BLAST of Neuronal guanine nucleotide exchange factor vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q5RDX5\|NGEF_PONAB	1.358e-28	28.97	Ephexin-1 OS=Pongo abelii OX=9601 GN=NGEF PE=2 SV=...	[more]
sp\|Q8N5V2\|NGEF_HUMAN	2.070e-28	28.97	Ephexin-1 OS=Homo sapiens OX=9606 GN=NGEF PE=1 SV=...	[more]
sp\|Q8CHT1\|NGEF_MOUSE	1.586e-27	28.69	Ephexin-1 OS=Mus musculus OX=10090 GN=Ngef PE=1 SV...	[more]
sp\|Q5BKC9\|NGEF_RAT	6.226e-27	28.97	Ephexin-1 OS=Rattus norvegicus OX=10116 GN=Ngef PE...	[more]
sp\|Q5FWH6\|ARHGF_MOUSE	9.361e-25	34.30	Rho guanine nucleotide exchange factor 15 OS=Mus m...	[more]

BLAST of Neuronal guanine nucleotide exchange factor vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A401PDJ3	1.706e-31	32.03	Uncharacterized protein OS=Scyliorhinus torazame O...	[more]
A0A401T0V1	7.090e-31	32.12	Uncharacterized protein OS=Chiloscyllium punctatum...	[more]
A0A5K4E9M8	8.033e-31	34.07	Putative guanine-nucleotide-exchange-factor OS=Sch...	[more]
A0A3Q0KCF1	8.233e-31	34.07	Putative guanine-nucleotide-exchange-factor OS=Sch...	[more]
G4V979	8.821e-31	34.07	Putative guanine-nucleotide-exchange-factor OS=Sch...	[more]

BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
si:dkey-38p12.3	3.153e-23	34.43	rho guanine nucleotide exchange factor 15-like [So...	[more]
arhgef16	1.152e-21	28.61	rho guanine nucleotide exchange factor 16 [Source:...	[more]
arhgef16	1.152e-21	28.61	rho guanine nucleotide exchange factor 16 [Source:...	[more]
ngef	5.071e-21	31.25	neuronal guanine nucleotide exchange factor [Sourc...	[more]
ARHGEF26	8.436e-19	28.25	Rho guanine nucleotide exchange factor 26 [Source:...	[more]

BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1


Match Name	E-value	Identity	Description
ENSPMAT00000000490.1	6.095e-18	28.57	pep scaffold:Pmarinus_7.0:GL477825:44699:67115:1 g...	[more]

BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 2


Match Name	E-value	Identity	Description
ROM2	5.953e-8	30.43	Guanine nucleotide exchange factor (GEF) for Rho1p...	[more]
ROM1	2.201e-7	28.33	Guanine nucleotide exchange factor (GEF) for Rho1p...	[more]

BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1


Match Name	E-value	Identity	Description
EDO39595	8.466e-20	26.04	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Neuronal guanine nucleotide exchange factor vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
arhgef16	6.179e-24	29.53	rho guanine nucleotide exchange factor 16 [Source:...	[more]
arhgef16	6.179e-24	29.53	rho guanine nucleotide exchange factor 16 [Source:...	[more]
si:dkey-38p12.3	4.385e-21	32.97	ephexin-1 [Source:NCBI gene;Acc:101161585]	[more]
ARHGEF26	1.199e-20	30.97	Rho guanine nucleotide exchange factor 26 [Source:...	[more]
ngef	1.418e-18	33.62	neuronal guanine nucleotide exchange factor [Sourc...	[more]

BLAST of Neuronal guanine nucleotide exchange factor vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000003812.1	0.000e+0	99.48	SMESG000003812.1	[more]
SMESG000044434.1	1.298e-31	33.82	SMESG000044434.1	[more]
SMESG000056271.1	1.317e-24	35.37	SMESG000056271.1	[more]
SMESG000056271.1	1.569e-24	35.37	SMESG000056271.1	[more]
SMESG000056271.1	1.033e-19	35.43	SMESG000056271.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30031446 ID=SMED30031446|Name=Neuronal guanine nucleotide exchange factor|organism=Schmidtea mediterranea sexual|type=transcript|length=2017bp
GATGTCCACATGGGTGAAGCAAATGAGATTAAAATATGAAAAACTAAAAC
TAGACAGATCTAATGCGAATTCAAAAAAACCGGTTTCACCTAAAGATAAA
ACAACATCTGTCAGATCAAATTGTGAGAGAAGTCAGAAGAAATTGGAATC
AGAAAATGGTTCTTTTGACAGTAAAAATAACGTATCACAAAATTCAATTT
CAAATTTAGGATTGAAGCCCTCAGAAATAGTTAATGAACACAATATTTGC
ATTTATTCTGACCCTGAATCAGACTCATTATATGGATCGTTCAGAAAGCG
TGAAAATGTCAGCAGCTTAAATCCTGGCAAATCTTCAGAAAATGATATCA
TTCTCAGATTAAAGACTGGAGAATCAGAATTTCAAACCATTAAAAGGTAC
GAATCGATTTTACGGCCCCCCTTATTTCAGCATATTAATGTGTCAAAACG
TCGCAAGGAAAATTTCGAAGATAAACCGAGAAAAACAAGTCTTGTGGCTA
CATTAATAGATGCATTTAATCACCAAAAGATTTCTAATAATAACCAAGAA
GCACTAAATGACATAGACCTTGTAGATTGCATTTTCAAAGACGACAGGTC
ACGAAACTCGTCTCGGAAGCCAGGAAAAATATGTCAGGAGTTGAAAGAAA
ATCGAAACTTGAAATGGATCGAAACAGAGCAAGTAAAATCAAAGGGCTTA
GCGAAAAATATGAAGAAAGAAGAAATCAAATTCCAGGAAAGTCAGTTTGA
AATAATATCATCGGAAGCTTCCTACAACAGAAGTTTGTCTGTTCTGATAG
ATAAATTCTACAATGCACCCCAAATGAGTCTAGTTGAAACCAATGGAATC
AAACCGATAATCAAGCCATACCAAAAGGAACATTTATTCTCAAACATTCT
CAAAATATACACCATTAGTTGCAAGTTCCTTGCCGATCTAGAAAGAAGGT
TTTGCGAATCCGCCAAAATCACAGACTTATCAGACATAGTCACAAAGTAT
GCCGTCAACGAATTTGATGTCTACGTGCCTTACATACAAAATCAAAGATT
TCAATCCGAAGCTTACAATGAACTCAAAAAGGAAATTGCAACTGCAAAAA
TAATTGAAGAGCTGGAAAGTCAACCCGAATGTTGTTCGCTCTCTCTGGAT
TCATTTCTACTGCTGCCTATGCAACGGTTATTGCGAATTTTATTGCTACT
CAAGGCTGTGAGAACAAATGCCCAACCTCAACAAAAACATGTCATTGAAC
TTGTGGATAAAGCCATTCAATATATTGAGAAAATTATTCACAAGTGCTCG
GAAAATAAGAATTATATCGACGAAAGACAAAGAATGATGGAAATAATTCG
ACACCTTGATTTCAAGCCGGGAAAGAAAATAAAAGAACAGCTGGGGAAGT
TAATACATGAAGGAGAAGTGAAACGAAGCAACAAGAATCCATCAAAGAAA
TTCATGTCAGAATCCATGAAATTCAAAGAATTTTGGTTCATCCTGACCTC
AGAATACTTGCTGATGACAAAACTGTCAAAAAAAGAAGTGACGTACAATG
TCGACGATTATTGCTCCTCGTCGGAAATCTTTGTGGAATATGAAACCATT
GAAGAGAATGGAAACATATTCCAATTCAAATTGCAAATTAATAGAAATTC
AGATGTGTGCGATGTATATCTGATTCAAACAAAAAATAAAGAGAGCCACA
AAAAGTGGATGAATTTATTATCGAATTCCTGAGAAAGGAGCGAGATAGTG
AAAATGCATATCATTTGTATATTTATTATCATTTCAGATGAAACTTTTTG
AATTTTCCAGGAAAAAATTTCAATTATTTTTTTATATATTCTACCAATAT
TTATAAAAATTTGTTGTTTTCAACTAATTTTCTAATAATTTATTATTAAT
AATTAAGTGAAATAAGTGAGTGTTAATACACCATTTCTAAATTGAATGAT
GGTGAATGACGTGGTAGTTTTGAGGTTTTATAGGATTGACAATATACCTT
AATATTGTGTGTAACTT

protein sequence of SMED30031446-orf-1

>SMED30031446-orf-1 ID=SMED30031446-orf-1|Name=SMED30031446-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=577bp
MSTWVKQMRLKYEKLKLDRSNANSKKPVSPKDKTTSVRSNCERSQKKLES
ENGSFDSKNNVSQNSISNLGLKPSEIVNEHNICIYSDPESDSLYGSFRKR
ENVSSLNPGKSSENDIILRLKTGESEFQTIKRYESILRPPLFQHINVSKR
RKENFEDKPRKTSLVATLIDAFNHQKISNNNQEALNDIDLVDCIFKDDRS
RNSSRKPGKICQELKENRNLKWIETEQVKSKGLAKNMKKEEIKFQESQFE
IISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNIL
KIYTISCKFLADLERRFCESAKITDLSDIVTKYAVNEFDVYVPYIQNQRF
QSEAYNELKKEIATAKIIEELESQPECCSLSLDSFLLLPMQRLLRILLLL
KAVRTNAQPQQKHVIELVDKAIQYIEKIIHKCSENKNYIDERQRMMEIIR
HLDFKPGKKIKEQLGKLIHEGEVKRSNKNPSKKFMSESMKFKEFWFILTS
EYLLMTKLSKKEVTYNVDDYCSSSEIFVEYETIEENGNIFQFKLQINRNS
DVCDVYLIQTKNKESHKKWMNLLSNS*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000016	pharynx
PLANA:0000020	protonephridia
PLANA:0000026	gut
PLANA:0000034	epidermis
PLANA:0002032	epidermal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR000219	DH-domain
IPR011993	PH-like_dom_sf
IPR001849	PH_domain

Vocabulary: **biological process**
Term	Definition
GO:0035023	regulation of Rho protein signal transduction
GO:0001886	endothelial cell morphogenesis
GO:0043065	positive regulation of apoptotic process
GO:0043547	positive regulation of GTPase activity
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0097178	ruffle assembly