Protein kinase domain-containing protein

Overview
NameProtein kinase domain-containing protein
Smed IDSMED30031370
Length (bp)2365
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Protein kinase domain-containing protein (SMED30031370) t-SNE clustered cells

Violin plots show distribution of expression levels for Protein kinase domain-containing protein (SMED30031370) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Protein kinase domain-containing protein (SMED30031370) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Protein kinase domain-containing protein (SMED30031370) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30031370

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
nervous systemSMED30031370h1SMcG0004273 dd_Smed_v4_14823_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30031370h1SMcG0004273 dd_Smed_v4_14823_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30031370h1SMcG0004273 dd_Smed_v4_14823_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30031370h1SMcG0004273 dd_Smed_v6_14823_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: MARK2 (microtubule affinity regulating kinase 2 [Source:HGNC Symbol;Acc:HGNC:3332])

HSP 1 Score: 200.29 bits (508), Expect = 5.797e-54
Identity = 109/269 (40.52%), Postives = 162/269 (60.22%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            IG Y+   +T+GKG+FA+V+L  H +T  +VA+KII+  ++    ++  L+RE RI+  LNHPNI+K +E +  +    L+ E A GG++ +Y+    + R  E  AR   RQ++SA+QY H+K +VHRDLK ENL+LD    ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C++L+K  L   P  R  +++I+  RW+
Sbjct:   17 IGNYRLL-KTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQK-LFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCENLLKKFLILNPSKRGTLEQIMKDRWM 271
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: MARK2 (microtubule affinity regulating kinase 2 [Source:HGNC Symbol;Acc:HGNC:3332])

HSP 1 Score: 200.29 bits (508), Expect = 6.440e-54
Identity = 109/269 (40.52%), Postives = 162/269 (60.22%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            IG Y+   +T+GKG+FA+V+L  H +T  +VA+KII+  ++    ++  L+RE RI+  LNHPNI+K +E +  +    L+ E A GG++ +Y+    + R  E  AR   RQ++SA+QY H+K +VHRDLK ENL+LD    ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C++L+K  L   P  R  +++I+  RW+
Sbjct:   50 IGNYRLL-KTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQK-LFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCENLLKKFLILNPSKRGTLEQIMKDRWM 304
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: MARK2 (microtubule affinity regulating kinase 2 [Source:HGNC Symbol;Acc:HGNC:3332])

HSP 1 Score: 200.29 bits (508), Expect = 7.253e-54
Identity = 109/269 (40.52%), Postives = 162/269 (60.22%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            IG Y+   +T+GKG+FA+V+L  H +T  +VA+KII+  ++    ++  L+RE RI+  LNHPNI+K +E +  +    L+ E A GG++ +Y+    + R  E  AR   RQ++SA+QY H+K +VHRDLK ENL+LD    ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C++L+K  L   P  R  +++I+  RW+
Sbjct:   50 IGNYRLL-KTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQK-LFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCENLLKKFLILNPSKRGTLEQIMKDRWM 304
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: MARK2 (microtubule affinity regulating kinase 2 [Source:HGNC Symbol;Acc:HGNC:3332])

HSP 1 Score: 200.29 bits (508), Expect = 8.922e-54
Identity = 109/269 (40.52%), Postives = 162/269 (60.22%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            IG Y+   +T+GKG+FA+V+L  H +T  +VA+KII+  ++    ++  L+RE RI+  LNHPNI+K +E +  +    L+ E A GG++ +Y+    + R  E  AR   RQ++SA+QY H+K +VHRDLK ENL+LD    ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C++L+K  L   P  R  +++I+  RW+
Sbjct:   50 IGNYRLL-KTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQK-LFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCENLLKKFLILNPSKRGTLEQIMKDRWM 304
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: MARK2 (microtubule affinity regulating kinase 2 [Source:HGNC Symbol;Acc:HGNC:3332])

HSP 1 Score: 199.904 bits (507), Expect = 9.325e-54
Identity = 109/269 (40.52%), Postives = 162/269 (60.22%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            IG Y+   +T+GKG+FA+V+L  H +T  +VA+KII+  ++    ++  L+RE RI+  LNHPNI+K +E +  +    L+ E A GG++ +Y+    + R  E  AR   RQ++SA+QY H+K +VHRDLK ENL+LD    ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C++L+K  L   P  R  +++I+  RW+
Sbjct:   17 IGNYRLL-KTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQK-LFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCENLLKKFLILNPSKRGTLEQIMKDRWM 271
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: par-1 (Serine/threonine-protein kinase par-1 [Source:UniProtKB/Swiss-Prot;Acc:Q9TW45])

HSP 1 Score: 219.164 bits (557), Expect = 9.417e-60
Identity = 129/341 (37.83%), Postives = 195/341 (57.18%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWVTNSDQIXXXXXXXXXXXXELKSQIIEKLAEFTSL--NKTEIERFVHENGTNELSAMFKMLLEETKVEMGYYE 1247
            +GKYK   +T+GKG+FA+V+L  H +T  +VA+KII+   +    ++  L+RE +I+ QL+HPNI+K Y+ +  +    L+ E A GG++ +Y+    + R  E  AR   RQ++SA+QY+H K ++HRDLK ENL+LD+   ++K+ DFG SN       L T CGSP YAAPELF+     GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C++L+K  L   PQ R  +D I+  RW+    +      F +P   ++  Q IEKL +   L  NK  I   V +    ++ A + +LL E K +M   E
Sbjct:  103 VGKYKLL-KTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQK-LFREVKIMKQLDHPNIVKLYQVMETEQTLYLVLEYASGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYLHSKNIIHRDLKAENLLLDQ-DMNIKIADFGFSNTFSLGNKLDTFCGSPPYAAPELFSGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCENLLKKFLVINPQRRSSLDNIMKDRWMNVGYEDDELKPFIEPPKDQIDEQRIEKLIQIFQLGFNKAAILESVEKEKFEDIHATY-LLLGERKSDMDASE 428
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: par-1 (Serine/threonine-protein kinase par-1 [Source:UniProtKB/Swiss-Prot;Acc:Q9TW45])

HSP 1 Score: 219.164 bits (557), Expect = 9.417e-60
Identity = 129/341 (37.83%), Postives = 195/341 (57.18%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWVTNSDQIXXXXXXXXXXXXELKSQIIEKLAEFTSL--NKTEIERFVHENGTNELSAMFKMLLEETKVEMGYYE 1247
            +GKYK   +T+GKG+FA+V+L  H +T  +VA+KII+   +    ++  L+RE +I+ QL+HPNI+K Y+ +  +    L+ E A GG++ +Y+    + R  E  AR   RQ++SA+QY+H K ++HRDLK ENL+LD+   ++K+ DFG SN       L T CGSP YAAPELF+     GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C++L+K  L   PQ R  +D I+  RW+    +      F +P   ++  Q IEKL +   L  NK  I   V +    ++ A + +LL E K +M   E
Sbjct:  103 VGKYKLL-KTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQK-LFREVKIMKQLDHPNIVKLYQVMETEQTLYLVLEYASGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYLHSKNIIHRDLKAENLLLDQ-DMNIKIADFGFSNTFSLGNKLDTFCGSPPYAAPELFSGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCENLLKKFLVINPQRRSSLDNIMKDRWMNVGYEDDELKPFIEPPKDQIDEQRIEKLIQIFQLGFNKAAILESVEKEKFEDIHATY-LLLGERKSDMDASE 428
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: par-1 (Serine/threonine-protein kinase par-1 [Source:UniProtKB/Swiss-Prot;Acc:Q9TW45])

HSP 1 Score: 219.164 bits (557), Expect = 9.417e-60
Identity = 129/341 (37.83%), Postives = 195/341 (57.18%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWVTNSDQIXXXXXXXXXXXXELKSQIIEKLAEFTSL--NKTEIERFVHENGTNELSAMFKMLLEETKVEMGYYE 1247
            +GKYK   +T+GKG+FA+V+L  H +T  +VA+KII+   +    ++  L+RE +I+ QL+HPNI+K Y+ +  +    L+ E A GG++ +Y+    + R  E  AR   RQ++SA+QY+H K ++HRDLK ENL+LD+   ++K+ DFG SN       L T CGSP YAAPELF+     GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C++L+K  L   PQ R  +D I+  RW+    +      F +P   ++  Q IEKL +   L  NK  I   V +    ++ A + +LL E K +M   E
Sbjct:  103 VGKYKLL-KTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQK-LFREVKIMKQLDHPNIVKLYQVMETEQTLYLVLEYASGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYLHSKNIIHRDLKAENLLLDQ-DMNIKIADFGFSNTFSLGNKLDTFCGSPPYAAPELFSGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCENLLKKFLVINPQRRSSLDNIMKDRWMNVGYEDDELKPFIEPPKDQIDEQRIEKLIQIFQLGFNKAAILESVEKEKFEDIHATY-LLLGERKSDMDASE 428
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: par-1 (Serine/threonine-protein kinase par-1 [Source:UniProtKB/Swiss-Prot;Acc:Q9TW45])

HSP 1 Score: 219.164 bits (557), Expect = 9.417e-60
Identity = 129/341 (37.83%), Postives = 195/341 (57.18%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWVTNSDQIXXXXXXXXXXXXELKSQIIEKLAEFTSL--NKTEIERFVHENGTNELSAMFKMLLEETKVEMGYYE 1247
            +GKYK   +T+GKG+FA+V+L  H +T  +VA+KII+   +    ++  L+RE +I+ QL+HPNI+K Y+ +  +    L+ E A GG++ +Y+    + R  E  AR   RQ++SA+QY+H K ++HRDLK ENL+LD+   ++K+ DFG SN       L T CGSP YAAPELF+     GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C++L+K  L   PQ R  +D I+  RW+    +      F +P   ++  Q IEKL +   L  NK  I   V +    ++ A + +LL E K +M   E
Sbjct:  103 VGKYKLL-KTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQK-LFREVKIMKQLDHPNIVKLYQVMETEQTLYLVLEYASGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYLHSKNIIHRDLKAENLLLDQ-DMNIKIADFGFSNTFSLGNKLDTFCGSPPYAAPELFSGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCENLLKKFLVINPQRRSSLDNIMKDRWMNVGYEDDELKPFIEPPKDQIDEQRIEKLIQIFQLGFNKAAILESVEKEKFEDIHATY-LLLGERKSDMDASE 428
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: par-1 (Serine/threonine-protein kinase par-1 [Source:UniProtKB/Swiss-Prot;Acc:Q9TW45])

HSP 1 Score: 219.164 bits (557), Expect = 9.417e-60
Identity = 129/341 (37.83%), Postives = 195/341 (57.18%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWVTNSDQIXXXXXXXXXXXXELKSQIIEKLAEFTSL--NKTEIERFVHENGTNELSAMFKMLLEETKVEMGYYE 1247
            +GKYK   +T+GKG+FA+V+L  H +T  +VA+KII+   +    ++  L+RE +I+ QL+HPNI+K Y+ +  +    L+ E A GG++ +Y+    + R  E  AR   RQ++SA+QY+H K ++HRDLK ENL+LD+   ++K+ DFG SN       L T CGSP YAAPELF+     GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C++L+K  L   PQ R  +D I+  RW+    +      F +P   ++  Q IEKL +   L  NK  I   V +    ++ A + +LL E K +M   E
Sbjct:  103 VGKYKLL-KTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQK-LFREVKIMKQLDHPNIVKLYQVMETEQTLYLVLEYASGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYLHSKNIIHRDLKAENLLLDQ-DMNIKIADFGFSNTFSLGNKLDTFCGSPPYAAPELFSGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCENLLKKFLVINPQRRSSLDNIMKDRWMNVGYEDDELKPFIEPPKDQIDEQRIEKLIQIFQLGFNKAAILESVEKEKFEDIHATY-LLLGERKSDMDASE 428
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: par-1 (gene:FBgn0260934 transcript:FBtr0301505)

HSP 1 Score: 197.978 bits (502), Expect = 7.860e-53
Identity = 107/269 (39.78%), Postives = 165/269 (61.34%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            IGKYK   +T+GKG+FA+V+L  H  T  +VA+KII+  ++    ++  L+RE RI+  L+HPNI+K ++ +  +    LI E A GG++ +Y+    + R  E  AR   RQ++SA+QY H+K ++HRDLK ENL+LD ++ ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF     D +  + L   + +G   K+     ++ST+C++L++  L   P  R  ++ I+  +W+
Sbjct:  250 IGKYKLI-KTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQK-LFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYL--VLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLD-SELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPF-----DGSTLRELRERVLRG---KYRIPF-YMSTDCENLLRKFLVLNPAKRASLETIMGDKWM 504
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: par-1 (gene:FBgn0260934 transcript:FBtr0330243)

HSP 1 Score: 197.978 bits (502), Expect = 8.274e-53
Identity = 107/269 (39.78%), Postives = 165/269 (61.34%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            IGKYK   +T+GKG+FA+V+L  H  T  +VA+KII+  ++    ++  L+RE RI+  L+HPNI+K ++ +  +    LI E A GG++ +Y+    + R  E  AR   RQ++SA+QY H+K ++HRDLK ENL+LD ++ ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF     D +  + L   + +G   K+     ++ST+C++L++  L   P  R  ++ I+  +W+
Sbjct:  250 IGKYKLI-KTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQK-LFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYL--VLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLD-SELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPF-----DGSTLRELRERVLRG---KYRIPF-YMSTDCENLLRKFLVLNPAKRASLETIMGDKWM 504
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: par-1 (gene:FBgn0260934 transcript:FBtr0100390)

HSP 1 Score: 197.593 bits (501), Expect = 9.978e-53
Identity = 107/269 (39.78%), Postives = 165/269 (61.34%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            IGKYK   +T+GKG+FA+V+L  H  T  +VA+KII+  ++    ++  L+RE RI+  L+HPNI+K ++ +  +    LI E A GG++ +Y+    + R  E  AR   RQ++SA+QY H+K ++HRDLK ENL+LD ++ ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF     D +  + L   + +G   K+     ++ST+C++L++  L   P  R  ++ I+  +W+
Sbjct:  250 IGKYKLI-KTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQK-LFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYL--VLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLD-SELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPF-----DGSTLRELRERVLRG---KYRIPF-YMSTDCENLLRKFLVLNPAKRASLETIMGDKWM 504
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: par-1 (gene:FBgn0260934 transcript:FBtr0086457)

HSP 1 Score: 197.593 bits (501), Expect = 2.692e-52
Identity = 107/269 (39.78%), Postives = 165/269 (61.34%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            IGKYK   +T+GKG+FA+V+L  H  T  +VA+KII+  ++    ++  L+RE RI+  L+HPNI+K ++ +  +    LI E A GG++ +Y+    + R  E  AR   RQ++SA+QY H+K ++HRDLK ENL+LD ++ ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF     D +  + L   + +G   K+     ++ST+C++L++  L   P  R  ++ I+  +W+
Sbjct:  373 IGKYKLI-KTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQK-LFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYL--VLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLD-SELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPF-----DGSTLRELRERVLRG---KYRIPF-YMSTDCENLLRKFLVLNPAKRASLETIMGDKWM 627
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: par-1 (gene:FBgn0260934 transcript:FBtr0086450)

HSP 1 Score: 197.208 bits (500), Expect = 3.262e-52
Identity = 107/269 (39.78%), Postives = 165/269 (61.34%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            IGKYK   +T+GKG+FA+V+L  H  T  +VA+KII+  ++    ++  L+RE RI+  L+HPNI+K ++ +  +    LI E A GG++ +Y+    + R  E  AR   RQ++SA+QY H+K ++HRDLK ENL+LD ++ ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF     D +  + L   + +G   K+     ++ST+C++L++  L   P  R  ++ I+  +W+
Sbjct:  250 IGKYKLI-KTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQK-LFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYL--VLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLD-SELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPF-----DGSTLRELRERVLRG---KYRIPF-YMSTDCENLLRKFLVLNPAKRASLETIMGDKWM 504
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: mark3a (MAP/microtubule affinity-regulating kinase 3a [Source:ZFIN;Acc:ZDB-GENE-030131-6232])

HSP 1 Score: 196.823 bits (499), Expect = 2.510e-54
Identity = 107/272 (39.34%), Postives = 161/272 (59.19%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWVTNS 1046
            IG Y+   +T+GKG+FA+V+L  H +T  +VA+K+I+  ++    ++  L RE  I+  LNHPNI+K +E +  +    L+ E A GG++ +Y+    + R  E  AR   RQ++SA+QY H+K +VHRDLK ENL+LD    ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C++L+K  L   P  R  +++I+  RW+ + 
Sbjct:   54 IGNYRLL-KTIGKGNFAKVKLARHILTGSEVAIKMIDKTQLNPTSLQK-LSREVTIMKNLNHPNIVKLFEVIETEKTLFLVMEYASGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLD-GDMNIKIADFGFSNEFMVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCENLLKRFLVLNPAKRGTLEQIMKERWINSG 311
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: mark2b (MAP/microtubule affinity-regulating kinase 2b [Source:ZFIN;Acc:ZDB-GENE-080215-4])

HSP 1 Score: 201.83 bits (512), Expect = 2.550e-54
Identity = 109/269 (40.52%), Postives = 162/269 (60.22%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            IG Y+   +T+GKG+FA+V+L  H +T  +VA+KII+  ++    ++  ++RE RI+  LNHPNI+K +E +  D    L+ E A GG++ +Y+    + R  E  AR   RQ++SA+QY H+K +VHRDLK ENL+LD    ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C++L+K  L   P  R  +++I+  RW+
Sbjct:   46 IGNYRLL-KTIGKGNFAKVKLARHVLTSKEVAVKIIDKTQLNSSSLQK-VFREVRIMKLLNHPNIVKLFEVIETDKTLYLVMEYASGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYCHQKCIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCENLLKKFLILNPTKRGSLEQIMKDRWM 300
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: mark2b (MAP/microtubule affinity-regulating kinase 2b [Source:ZFIN;Acc:ZDB-GENE-080215-4])

HSP 1 Score: 201.83 bits (512), Expect = 3.254e-54
Identity = 109/269 (40.52%), Postives = 162/269 (60.22%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            IG Y+   +T+GKG+FA+V+L  H +T  +VA+KII+  ++    ++  ++RE RI+  LNHPNI+K +E +  D    L+ E A GG++ +Y+    + R  E  AR   RQ++SA+QY H+K +VHRDLK ENL+LD    ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C++L+K  L   P  R  +++I+  RW+
Sbjct:   46 IGNYRLL-KTIGKGNFAKVKLARHVLTSKEVAVKIIDKTQLNSSSLQK-VFREVRIMKLLNHPNIVKLFEVIETDKTLYLVMEYASGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYCHQKCIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCENLLKKFLILNPTKRGSLEQIMKDRWM 300
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: mark2b (MAP/microtubule affinity-regulating kinase 2b [Source:ZFIN;Acc:ZDB-GENE-080215-4])

HSP 1 Score: 201.445 bits (511), Expect = 3.658e-54
Identity = 109/269 (40.52%), Postives = 162/269 (60.22%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            IG Y+   +T+GKG+FA+V+L  H +T  +VA+KII+  ++    ++  ++RE RI+  LNHPNI+K +E +  D    L+ E A GG++ +Y+    + R  E  AR   RQ++SA+QY H+K +VHRDLK ENL+LD    ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C++L+K  L   P  R  +++I+  RW+
Sbjct:   46 IGNYRLL-KTIGKGNFAKVKLARHVLTSKEVAVKIIDKTQLNSSSLQK-VFREVRIMKLLNHPNIVKLFEVIETDKTLYLVMEYASGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYCHQKCIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCENLLKKFLILNPTKRGSLEQIMKDRWM 300
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: mark3b (MAP/microtubule affinity-regulating kinase 3b [Source:ZFIN;Acc:ZDB-GENE-060929-80])

HSP 1 Score: 200.675 bits (509), Expect = 6.083e-54
Identity = 110/269 (40.89%), Postives = 162/269 (60.22%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            IG Y+   +T+GKG+FA+V+L  H +T  +VA+KII+  ++    ++  L+RE RI+  LNHPNI+K +E +  D    L+ E A GG++ +Y+    + R  E  AR   RQ++SA+QY H+K +VHRDLK ENL+LD    ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C++L+K  L   P  R  +++I+  RW+
Sbjct:   53 IGNYRL-LKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQK-LFREVRIMKILNHPNIVKLFEVIETDKTLYLVMEYASGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTIGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCENLLKRFLVLNPVKRGTLEQIMKDRWI 307
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: ENSXETT00000045307.1 (MAP/microtubule affinity-regulating kinase 4 [Source:NCBI gene;Acc:100491038])

HSP 1 Score: 209.534 bits (532), Expect = 1.843e-57
Identity = 121/346 (34.97%), Postives = 193/346 (55.78%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWVT---NSDQIXXXXXXXXXXXXELKSQIIEKLAEFTSLNKTEIERFVHENGTNELSAMFKMLLEETKVEMGYYEEDHT 1259
            +G Y+    T+GKG+FA+V+L  H +T  +VA+KII+  ++    ++  L+RE RI+  LNHPNI+K +E +  +    LI E A GG++ +Y+    + R  E  AR   RQ++SA+ Y H+K +VHRDLK ENL+LD ++ ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C+ +++  L   P  R  +D+I+N +W+    +SD +       +      + +I+ ++      ++ EI+  +  N  NE+ A + +L  + + E G    D T
Sbjct:   48 VGNYRLL-RTIGKGNFAKVKLARHVLTGREVAIKIIDKTQLNPSSLQK-LFREVRIMKGLNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYL--VSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLD-SESNIKIADFGFSNEFTPGGKLDTFCGSPPYAAPELFQGKRYNGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCEGVLRRFLVLNPSKRCTLDQIMNDKWMNIGFDSDDLKPYKEPEEDNADPKRIEIMLEMG----YSREEIKDALSSNKYNEVMATYLLLGRKPESEGGESRSDST 375
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: ENSXETT00000045494.1 (MAP/microtubule affinity-regulating kinase 4 [Source:NCBI gene;Acc:100491038])

HSP 1 Score: 206.838 bits (525), Expect = 3.712e-57
Identity = 121/346 (34.97%), Postives = 193/346 (55.78%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWVT---NSDQIXXXXXXXXXXXXELKSQIIEKLAEFTSLNKTEIERFVHENGTNELSAMFKMLLEETKVEMGYYEEDHT 1259
            +G Y+    T+GKG+FA+V+L  H +T  +VA+KII+  ++    ++  L+RE RI+  LNHPNI+K +E +  +    LI E A GG++ +Y+    + R  E  AR   RQ++SA+ Y H+K +VHRDLK ENL+LD ++ ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C+ +++  L   P  R  +D+I+N +W+    +SD +       +      + +I+ ++      ++ EI+  +  N  NE+ A + +L  + + E G    D T
Sbjct:   48 VGNYRLL-RTIGKGNFAKVKLARHVLTGREVAIKIIDKTQLNPSSLQK-LFREVRIMKGLNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYL--VSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLD-SESNIKIADFGFSNEFTPGGKLDTFCGSPPYAAPELFQGKRYNGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCEGVLRRFLVLNPSKRCTLDQIMNDKWMNIGFDSDDLKPYKEPEEDNADPKRIEIMLEMG----YSREEIKDALSSNKYNEVMATYLLLGRKPESEGGESRSDST 375
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: ENSXETT00000045259.1 (MAP/microtubule affinity-regulating kinase 4 [Source:NCBI gene;Acc:100491038])

HSP 1 Score: 209.149 bits (531), Expect = 5.823e-57
Identity = 121/346 (34.97%), Postives = 193/346 (55.78%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWVT---NSDQIXXXXXXXXXXXXELKSQIIEKLAEFTSLNKTEIERFVHENGTNELSAMFKMLLEETKVEMGYYEEDHT 1259
            +G Y+    T+GKG+FA+V+L  H +T  +VA+KII+  ++    ++  L+RE RI+  LNHPNI+K +E +  +    LI E A GG++ +Y+    + R  E  AR   RQ++SA+ Y H+K +VHRDLK ENL+LD ++ ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C+ +++  L   P  R  +D+I+N +W+    +SD +       +      + +I+ ++      ++ EI+  +  N  NE+ A + +L  + + E G    D T
Sbjct:   48 VGNYRL-LRTIGKGNFAKVKLARHVLTGREVAIKIIDKTQLNPSSLQK-LFREVRIMKGLNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYL--VSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLD-SESNIKIADFGFSNEFTPGGKLDTFCGSPPYAAPELFQGKRYNGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCEGVLRRFLVLNPSKRCTLDQIMNDKWMNIGFDSDDLKPYKEPEEDNADPKRIEIMLEMG----YSREEIKDALSSNKYNEVMATYLLLGRKPESEGGESRSDST 375
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: ENSXETT00000045413.1 (MAP/microtubule affinity-regulating kinase 4 [Source:NCBI gene;Acc:100491038])

HSP 1 Score: 203.756 bits (517), Expect = 8.192e-56
Identity = 118/336 (35.12%), Postives = 190/336 (56.55%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWVT---NSDQIXXXXXXXXXXXXELKSQIIEKLAEFTSLNKTEIERFVHENGTNELSAMFKMLLEETKV 1229
            +G Y+    T+GKG+FA+V+L  H +T  +VA+KII+  ++    ++  L+RE RI+  LNHPNI+K +E +  +    LI E A GG++ +Y+    + R  E  AR   RQ++SA+ Y H+K +VHRDLK ENL+LD ++ ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C+ +++  L   P  R  +D+I+N +W+    +SD +       +      + +I+ ++      ++ EI+  +  N  NE+ A + +L  + +V
Sbjct:   45 VGNYRLL-RTIGKGNFAKVKLARHVLTGREVAIKIIDKTQLNPSSLQK-LFREVRIMKGLNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYL--VSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLD-SESNIKIADFGFSNEFTPGGKLDTFCGSPPYAAPELFQGKRYNGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCEGVLRRFLVLNPSKRCTLDQIMNDKWMNIGFDSDDLKPYKEPEEDNADPKRIEIMLEMG----YSREEIKDALSSNKYNEVMATYLLLGRKPEV 362
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: ENSXETT00000045600.1 (MAP/microtubule affinity-regulating kinase 4 [Source:NCBI gene;Acc:100491038])

HSP 1 Score: 202.601 bits (514), Expect = 8.640e-56
Identity = 118/336 (35.12%), Postives = 190/336 (56.55%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWVT---NSDQIXXXXXXXXXXXXELKSQIIEKLAEFTSLNKTEIERFVHENGTNELSAMFKMLLEETKV 1229
            +G Y+    T+GKG+FA+V+L  H +T  +VA+KII+  ++    ++  L+RE RI+  LNHPNI+K +E +  +    LI E A GG++ +Y+    + R  E  AR   RQ++SA+ Y H+K +VHRDLK ENL+LD ++ ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C+ +++  L   P  R  +D+I+N +W+    +SD +       +      + +I+ ++      ++ EI+  +  N  NE+ A + +L  + +V
Sbjct:   48 VGNYRLL-RTIGKGNFAKVKLARHVLTGREVAIKIIDKTQLNPSSLQK-LFREVRIMKGLNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYL--VSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLD-SESNIKIADFGFSNEFTPGGKLDTFCGSPPYAAPELFQGKRYNGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCEGVLRRFLVLNPSKRCTLDQIMNDKWMNIGFDSDDLKPYKEPEEDNADPKRIEIMLEMG----YSREEIKDALSSNKYNEVMATYLLLGRKPEV 365
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Mark2 (MAP/microtubule affinity regulating kinase 2 [Source:MGI Symbol;Acc:MGI:99638])

HSP 1 Score: 200.29 bits (508), Expect = 5.128e-54
Identity = 109/269 (40.52%), Postives = 162/269 (60.22%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            IG Y+   +T+GKG+FA+V+L  H +T  +VA+KII+  ++    ++  L+RE RI+  LNHPNI+K +E +  +    L+ E A GG++ +Y+    + R  E  AR   RQ++SA+QY H+K +VHRDLK ENL+LD    ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C++L+K  L   P  R  +++I+  RW+
Sbjct:   50 IGNYRLL-KTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQK-LFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCENLLKKFLILNPSKRGTLEQIMKDRWM 304
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Mark2 (MAP/microtubule affinity regulating kinase 2 [Source:MGI Symbol;Acc:MGI:99638])

HSP 1 Score: 200.29 bits (508), Expect = 5.225e-54
Identity = 109/269 (40.52%), Postives = 162/269 (60.22%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            IG Y+   +T+GKG+FA+V+L  H +T  +VA+KII+  ++    ++  L+RE RI+  LNHPNI+K +E +  +    L+ E A GG++ +Y+    + R  E  AR   RQ++SA+QY H+K +VHRDLK ENL+LD    ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C++L+K  L   P  R  +++I+  RW+
Sbjct:   50 IGNYRLL-KTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQK-LFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCENLLKKFLILNPSKRGTLEQIMKDRWM 304
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Mark2 (MAP/microtubule affinity regulating kinase 2 [Source:MGI Symbol;Acc:MGI:99638])

HSP 1 Score: 200.29 bits (508), Expect = 6.065e-54
Identity = 109/269 (40.52%), Postives = 162/269 (60.22%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            IG Y+   +T+GKG+FA+V+L  H +T  +VA+KII+  ++    ++  L+RE RI+  LNHPNI+K +E +  +    L+ E A GG++ +Y+    + R  E  AR   RQ++SA+QY H+K +VHRDLK ENL+LD    ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C++L+K  L   P  R  +++I+  RW+
Sbjct:   50 IGNYRLL-KTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQK-LFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCENLLKKFLILNPSKRGTLEQIMKDRWM 304
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Mark2 (MAP/microtubule affinity regulating kinase 2 [Source:MGI Symbol;Acc:MGI:99638])

HSP 1 Score: 199.904 bits (507), Expect = 7.455e-54
Identity = 109/269 (40.52%), Postives = 162/269 (60.22%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            IG Y+   +T+GKG+FA+V+L  H +T  +VA+KII+  ++    ++  L+RE RI+  LNHPNI+K +E +  +    L+ E A GG++ +Y+    + R  E  AR   RQ++SA+QY H+K +VHRDLK ENL+LD    ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C++L+K  L   P  R  +++I+  RW+
Sbjct:   50 IGNYRLL-KTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQK-LFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCENLLKKFLILNPSKRGTLEQIMKDRWM 304
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Mark3 (MAP/microtubule affinity regulating kinase 3 [Source:MGI Symbol;Acc:MGI:1341865])

HSP 1 Score: 199.904 bits (507), Expect = 8.447e-54
Identity = 110/269 (40.89%), Postives = 162/269 (60.22%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            IG Y+   +T+GKG+FA+V+L  H +T  +VA+KII+  ++    ++  L+RE RI+  LNHPNI+K +E +  +    LI E A GG++ +Y+    + R  E  AR   RQ++SA+QY H+K +VHRDLK ENL+LD    ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C++L+K  L   P  R  +++I+  RW+
Sbjct:   53 IGNYRL-LKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQK-LFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCENLLKRFLVLNPVKRGTLEQIMKDRWI 307
[Close]
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9TW45|PAR1_CAEEL (Serine/threonine-protein kinase par-1 OS=Caenorhabditis elegans OX=6239 GN=par-1 PE=1 SV=1)

HSP 1 Score: 219.935 bits (559), Expect = 2.051e-58
Identity = 129/341 (37.83%), Postives = 195/341 (57.18%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWVTNSDQIXXXXXXXXXXXXELKSQIIEKLAEFTSL--NKTEIERFVHENGTNELSAMFKMLLEETKVEMGYYE 1247
            +GKYK   +T+GKG+FA+V+L  H +T  +VA+KII+   +    ++  L+RE +I+ QL+HPNI+K Y+ +  +    L+ E A GG++ +Y+    + R  E  AR   RQ++SA+QY+H K ++HRDLK ENL+LD+   ++K+ DFG SN       L T CGSP YAAPELF+     GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C++L+K  L   PQ R  +D I+  RW+    +      F +P   ++  Q IEKL +   L  NK  I   V +    ++ A + +LL E K +M   E
Sbjct:  167 VGKYKLL-KTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQK-LFREVKIMKQLDHPNIVKLYQVMETEQTLYLVLEYASGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYLHSKNIIHRDLKAENLLLDQ-DMNIKIADFGFSNTFSLGNKLDTFCGSPPYAAPELFSGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCENLLKKFLVINPQRRSSLDNIMKDRWMNVGYEDDELKPFIEPPKDQIDEQRIEKLIQIFQLGFNKAAILESVEKEKFEDIHATY-LLLGERKSDMDASE 492
[Close]
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|A8WYE4|PAR1_CAEBR (Serine/threonine-protein kinase par-1 OS=Caenorhabditis briggsae OX=6238 GN=par-1 PE=3 SV=1)

HSP 1 Score: 218.394 bits (555), Expect = 4.427e-58
Identity = 128/340 (37.65%), Postives = 194/340 (57.06%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWVTNSDQIXXXXXXXXXXXXELKSQIIEKLAEFTSL--NKTEIERFVHENGTNELSAMFKMLLEETKVEMGYY 1244
            +GKYK   +T+GKG+FA+V+L  H +T  +VA+KII+   +    ++  L+RE +I+ QL+HPNI+K Y+ +  +    L+ E A GG++ +Y+    + R  E  AR   RQ++SA+QY+H K ++HRDLK ENL+LD+   ++K+ DFG SN       L T CGSP YAAPELF+     GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C++L+K  L   PQ R  +D I+  RW+    +      F +P   ++  Q IEKL +   L  NK  I   V +    ++ A + +LL E K +   Y
Sbjct:  125 VGKYKLL-KTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQK-LFREVKIMKQLDHPNIVKLYQVMETEQTLYLVLEYASGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYLHSKNIIHRDLKAENLLLDQ-DMNIKIADFGFSNTFSLGNKLDTFCGSPPYAAPELFSGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCENLLKKFLVINPQRRSSLDNIMKDRWMNVGYEDDELKPFIEPPKDQIDEQRIEKLIQIFQLGFNKATILESVEKEKFEDIHATY-LLLGERKSDPSRY 449
[Close]
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q05512|MARK2_MOUSE (Serine/threonine-protein kinase MARK2 OS=Mus musculus OX=10090 GN=Mark2 PE=1 SV=3)

HSP 1 Score: 201.06 bits (510), Expect = 3.952e-53
Identity = 109/269 (40.52%), Postives = 163/269 (60.59%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            IG Y+   +T+GKG+FA+V+L  H +T  +VA+KII+  ++    ++  L+RE RI+  LNHPNI+K +E +  +    L+ E A GG++ +Y+    + R  E  AR   RQ++SA+QY H+K +VHRDLK ENL+LD    ++K+ DFG SN       L T CGSP YAAPELF    + GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C++L+K  L   P  R  +++I+  RW+
Sbjct:   50 IGNYRLL-KTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQK-LFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKIDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCENLLKKFLILNPSKRGTLEQIMKDRWM 304
[Close]
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|O08679|MARK2_RAT (Serine/threonine-protein kinase MARK2 OS=Rattus norvegicus OX=10116 GN=Mark2 PE=1 SV=1)

HSP 1 Score: 199.904 bits (507), Expect = 4.828e-53
Identity = 109/269 (40.52%), Postives = 162/269 (60.22%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            IG Y+   +T+GKG+FA+V+L  H +T  +VA+KII+  ++    ++  L+RE RI+  LNHPNI+K +E +  +    L+ E A GG++ +Y+    + R  E  AR   RQ++SA+QY H+K +VHRDLK ENL+LD    ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C++L+K  L   P  R  +++I+  RW+
Sbjct:   50 IGNYRLL-KTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQK-LFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCENLLKKFLILNPSKRGTLEQIMKDRWM 304
[Close]
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q03141|MARK3_MOUSE (MAP/microtubule affinity-regulating kinase 3 OS=Mus musculus OX=10090 GN=Mark3 PE=1 SV=2)

HSP 1 Score: 199.904 bits (507), Expect = 8.961e-53
Identity = 110/269 (40.89%), Postives = 162/269 (60.22%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            IG Y+   +T+GKG+FA+V+L  H +T  +VA+KII+  ++    ++  L+RE RI+  LNHPNI+K +E +  +    LI E A GG++ +Y+    + R  E  AR   RQ++SA+QY H+K +VHRDLK ENL+LD    ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C++L+K  L   P  R  +++I+  RW+
Sbjct:   53 IGNYRL-LKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQK-LFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCENLLKRFLVLNPVKRGTLEQIMKDRWI 307
[Close]
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A210QK57 (Serine/threonine-protein kinase par-1 OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT07976 PE=4 SV=1)

HSP 1 Score: 416.772 bits (1070), Expect = 7.848e-126
Identity = 191/353 (54.11%), Postives = 263/353 (74.50%), Query Frame = 3 
Query:  210 MGRKIQSIGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWVTNSDQIXXXXXXXXXXXXELKSQIIEKLAEFTSLNKTEIERFVHENGTNELSAMFKMLLEETKVEMGYYEEDHTNRP 1268
            MG+KIQ IG+Y     TLGKG+FARVEL  H VT CKVA+KII+TRKI E+Y+R NL+REARIL QL HPNI++ YE+L+A   YC++ ECA GG+L  Y+KTF     PE+ AR YLRQL+SA+ Y+HEKGV HRDLKMEN+MLD+ K+++K++DFGLSN    NEL+ THCGS EYAAPELF+    YGPE+DIWS GIVLYA V G LPF +PY D  RR++LL  I KGL  +H +EM H++++CKD++K +LEP P LR+ + EI  H WVT ++++PF  +   P+   +K++++++L++  S+ K ++E+ VHE   ++LSAMF M+++  + E G +E D+T +P
Sbjct:    1 MGKKIQCIGRYVMDGVTLGKGNFARVELATHGVTACKVAIKIIDTRKIKEEYVRQNLHREARILGQLRHPNIVRLYETLKATTLYCIVLECASGGNLLAYIKTFKDFLLPEERARPYLRQLVSAVHYLHEKGVAHRDLKMENIMLDEKKKNIKIVDFGLSNTFNPNELMKTHCGSLEYAAPELFSPAGKYGPEIDIWSIGIVLYAIVVGKLPFTTPYTDQYRREKLLQQIEKGLIEQHNREMAHITSDCKDILKKILEPNPDLRLSVVEIEKHPWVTYNEKMPFYAFHAFPRDKGMKAKVMDELSDMLSMKKDQVEKTVHECKCDDLSAMFNMIMDTKRCEKGLFEIDYTTQP 353
[Close]
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A1S3IJZ4 (serine/threonine-protein kinase MARK2 isoform X1 OS=Lingula unguis OX=7574 GN=LOC106165036 PE=4 SV=1)

HSP 1 Score: 411.764 bits (1057), Expect = 1.160e-125
Identity = 194/350 (55.43%), Postives = 256/350 (73.14%), Query Frame = 3 
Query:  210 MGRKIQSIGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWVTNSDQIXXXXXXXXXXXXELKSQIIEKLAEFTSLNKTEIERFVHENGTNELSAMFKMLLEETKVEMGYYEEDHT 1259
            MG+KIQ IG+Y    +TLGKG+FARVEL +H +T+CKVA+K+I  +KI E Y+R NLYREARILSQL HPNI++ +E+LRA   YCL+TE A GG+L  Y++T    R  E  A  Y+RQLISA+ Y+HE+GVVHRDLKMEN++LD+ K+++K++DFGLSN+    E+L THCGSPEYAAPELFTT   YGPE+DIWS GI +YA + G LPF +P+ D  RRQ LL  I KGL  +H KEM HLS +C+ L++ ++EP P  R+PM EI  H WVT S   PF PY   P+   L++Q+IE+++    L+  E+E+ VHE  ++ELSAMF M++E  K E G+Y+ DHT
Sbjct:    1 MGKKIQCIGRYSMENKTLGKGNFARVELAVHNITQCKVAIKVIEVQKIKESYVRKNLYREARILSQLRHPNIVRLFETLRAGTLYCLVTEYAAGGELLSYIRTQKDCRLSEQQAWPYVRQLISALCYLHERGVVHRDLKMENILLDEKKKNIKIVDFGLSNSFTAEEMLKTHCGSPEYAAPELFTTGKTYGPEIDIWSLGINMYALLVGKLPFTAPFNDERRRQMLLQQIQKGLCLQHDKEMAHLSPDCRSLLRQLIEPNPDYRLPMIEIEVHHWVTRSGACPFYPYQAPPRDRTLRTQVIEEVSGLMDLDPKEVEKKVHEYRSDELSAMFNMMVEAQKKEQGFYDLDHT 350
[Close]
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A2C9JHR7 (Protein kinase domain-containing protein OS=Biomphalaria glabrata OX=6526 GN=106058494 PE=4 SV=1)

HSP 1 Score: 387.111 bits (993), Expect = 5.544e-114
Identity = 182/350 (52.00%), Postives = 250/350 (71.43%), Query Frame = 3 
Query:  210 MGRKIQSIGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWVTNSDQIXXXXXXXXXXXXELKSQIIEKLAEFTSLNKTEIERFVHENGTNELSAMFKMLLEETKVEMGYYEEDHT 1259
            MG+KIQ IG+Y      LGKGSFARVEL  H VT CKVA+KII+TRK+ E+Y +NN+ RE+RIL QL HPNI++ YE+L+A   +CL+ E A GG+L  ++K     R  ED  R Y+RQL+SA+ Y+HE+GV HRDLKMEN+MLD  K+++K++DFGLSN   ++EL+ THCGSPEYAAPELFT    YG E+DIWSFGIV+YA + G LPF +PY D  RRQ+L+  + KGL   H +EM HLS +C+DL++ V+EP P LR+P+ ++  H W+T + + PF P+   P+   +K+Q +E+LA    + K  +E+ V EN ++E SAMF M+L+  + + G Y+ DHT
Sbjct:    1 MGKKIQCIGRYALEGHLLGKGSFARVELAHHSVTGCKVAIKIIDTRKLKEEYQKNNVQRESRILGQLRHPNIVRLYETLKATTLHCLVMEYASGGELQAFIKLQKDFRLSEDRGRPYIRQLVSALHYLHERGVAHRDLKMENIMLDTPKKNIKMVDFGLSNTFSKDELMKTHCGSPEYAAPELFTPGEKYGLEIDIWSFGIVMYAMLVGKLPFTTPYTDQYRRQKLVQQMEKGLVDVHHQEMAHLSADCQDLLQRVIEPSPSLRLPLLDMEIHSWITENGKKPFFPFGTFPRDKNMKTQTLEELATALGMKKEILEQKVAENKSDEYSAMFNMILDRKRQQQGIYDVDHT 350
[Close]
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A2C9JHR5 (Protein kinase domain-containing protein OS=Biomphalaria glabrata OX=6526 GN=106058494 PE=4 SV=1)

HSP 1 Score: 374.785 bits (961), Expect = 9.028e-111
Identity = 180/362 (49.72%), Postives = 249/362 (68.78%), Query Frame = 3 
Query:  210 MGRKIQSIGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWVTNSDQIXXXXXXXXXXXXELKSQIIEKL------------AEFTSLNKTEIERFVHENGTNELSAMFKMLLEETKVEMGYYEEDHT 1259
            MG+KIQ IG+Y      LGKGSFARVEL  H VT CKVA+KII+TRK+ E+Y +NN+ RE+RIL QL HPNI++ YE+L+A   +CL+ E A GG+L  ++K     R  ED  R Y+RQL+SA+ Y+HE+GV HRDLKMEN+MLD  K+++K++DFGLSN   ++EL+ THCGSPEYAAPELFT    YG E+DIWSFGIV+YA + G LPF +PY D  RRQ+L+  + KGL   H +EM HLS +C+DL++ V+EP P LR+P+ ++  H W+T + + PF P+   P+   +K+Q+ + +            A    + K  +E+ V EN ++E SAMF M+L+  + + G Y+ DHT
Sbjct:    1 MGKKIQCIGRYALEGHLLGKGSFARVELAHHSVTGCKVAIKIIDTRKLKEEYQKNNVQRESRILGQLRHPNIVRLYETLKATTLHCLVMEYASGGELQAFIKLQKDFRLSEDRGRPYIRQLVSALHYLHERGVAHRDLKMENIMLDTPKKNIKMVDFGLSNTFSKDELMKTHCGSPEYAAPELFTPGEKYGLEIDIWSFGIVMYAMLVGKLPFTTPYTDQYRRQKLVQQMEKGLVDVHHQEMAHLSADCQDLLQRVIEPSPSLRLPLLDMEIHSWITENGKKPFFPFGTFPRDKNMKTQLQDSMTSLEEDETLEELATALGMKKEILEQKVAENKSDEYSAMFNMILDRKRQQQGIYDVDHT 362
[Close]
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A2C9JHR6 (Protein kinase domain-containing protein OS=Biomphalaria glabrata OX=6526 GN=106058494 PE=4 SV=1)

HSP 1 Score: 375.555 bits (963), Expect = 2.542e-110
Identity = 180/362 (49.72%), Postives = 249/362 (68.78%), Query Frame = 3 
Query:  210 MGRKIQSIGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWVTNSDQIXXXXXXXXXXXXELKSQIIEKL------------AEFTSLNKTEIERFVHENGTNELSAMFKMLLEETKVEMGYYEEDHT 1259
            MG+KIQ IG+Y      LGKGSFARVEL  H VT CKVA+KII+TRK+ E+Y +NN+ RE+RIL QL HPNI++ YE+L+A   +CL+ E A GG+L  ++K     R  ED  R Y+RQL+SA+ Y+HE+GV HRDLKMEN+MLD  K+++K++DFGLSN   ++EL+ THCGSPEYAAPELFT    YG E+DIWSFGIV+YA + G LPF +PY D  RRQ+L+  + KGL   H +EM HLS +C+DL++ V+EP P LR+P+ ++  H W+T + + PF P+   P+   +K+Q+ + +            A    + K  +E+ V EN ++E SAMF M+L+  + + G Y+ DHT
Sbjct:    1 MGKKIQCIGRYALEGHLLGKGSFARVELAHHSVTGCKVAIKIIDTRKLKEEYQKNNVQRESRILGQLRHPNIVRLYETLKATTLHCLVMEYASGGELQAFIKLQKDFRLSEDRGRPYIRQLVSALHYLHERGVAHRDLKMENIMLDTPKKNIKMVDFGLSNTFSKDELMKTHCGSPEYAAPELFTPGEKYGLEIDIWSFGIVMYAMLVGKLPFTTPYTDQYRRQKLVQQMEKGLVDVHHQEMAHLSADCQDLLQRVIEPSPSLRLPLLDMEIHSWITENGKKPFFPFGTFPRDKNMKTQLQDSMTSLEEDETLEELATALGMKKEILEQKVAENKSDEYSAMFNMILDRKRQQQGIYDVDHT 362
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: mark3a (microtubule affinity regulating kinase 3 [Source:NCBI gene;Acc:103040919])

HSP 1 Score: 204.142 bits (518), Expect = 1.031e-55
Identity = 108/269 (40.15%), Postives = 162/269 (60.22%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            +G Y+   +T+GKG+FA+V+L  H +T  +VA+KII+  ++    ++  L+RE RI+  LNHPNI+K +E +  +    L+ E A GG++ +Y+    + R  E  AR   RQ++SA+QY H+K +VHRDLK ENL+LD    ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C++L+K  L   P  R  +++I+  RW+
Sbjct:   54 VGNYRLL-KTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQK-LFREVRIMKILNHPNIVKLFEVIETEKTLFLVMEYASGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCENLLKRFLVLNPGKRGTLEQIMRDRWI 308
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: mark3a (microtubule affinity regulating kinase 3 [Source:NCBI gene;Acc:103040919])

HSP 1 Score: 204.142 bits (518), Expect = 1.247e-55
Identity = 108/269 (40.15%), Postives = 162/269 (60.22%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            +G Y+   +T+GKG+FA+V+L  H +T  +VA+KII+  ++    ++  L+RE RI+  LNHPNI+K +E +  +    L+ E A GG++ +Y+    + R  E  AR   RQ++SA+QY H+K +VHRDLK ENL+LD    ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C++L+K  L   P  R  +++I+  RW+
Sbjct:   54 VGNYRLL-KTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQK-LFREVRIMKILNHPNIVKLFEVIETEKTLFLVMEYASGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCENLLKRFLVLNPGKRGTLEQIMRDRWI 308
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: mark3a (microtubule affinity regulating kinase 3 [Source:NCBI gene;Acc:103040919])

HSP 1 Score: 203.371 bits (516), Expect = 6.043e-55
Identity = 108/269 (40.15%), Postives = 162/269 (60.22%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            +G Y+   +T+GKG+FA+V+L  H +T  +VA+KII+  ++    ++  L+RE RI+  LNHPNI+K +E +  +    L+ E A GG++ +Y+    + R  E  AR   RQ++SA+QY H+K +VHRDLK ENL+LD    ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C++L+K  L   P  R  +++I+  RW+
Sbjct:   54 VGNYRLL-KTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQK-LFREVRIMKILNHPNIVKLFEVIETEKTLFLVMEYASGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCENLLKRFLVLNPGKRGTLEQIMRDRWI 308
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: mark3a (microtubule affinity regulating kinase 3 [Source:NCBI gene;Acc:103040919])

HSP 1 Score: 202.986 bits (515), Expect = 6.635e-55
Identity = 108/269 (40.15%), Postives = 162/269 (60.22%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            +G Y+   +T+GKG+FA+V+L  H +T  +VA+KII+  ++    ++  L+RE RI+  LNHPNI+K +E +  +    L+ E A GG++ +Y+    + R  E  AR   RQ++SA+QY H+K +VHRDLK ENL+LD    ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C++L+K  L   P  R  +++I+  RW+
Sbjct:   54 VGNYRLL-KTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQK-LFREVRIMKILNHPNIVKLFEVIETEKTLFLVMEYASGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCENLLKRFLVLNPGKRGTLEQIMRDRWI 308
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: mark3a (microtubule affinity regulating kinase 3 [Source:NCBI gene;Acc:103040919])

HSP 1 Score: 202.216 bits (513), Expect = 1.054e-54
Identity = 108/269 (40.15%), Postives = 162/269 (60.22%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            +G Y+   +T+GKG+FA+V+L  H +T  +VA+KII+  ++    ++  L+RE RI+  LNHPNI+K +E +  +    L+ E A GG++ +Y+    + R  E  AR   RQ++SA+QY H+K +VHRDLK ENL+LD    ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C++L+K  L   P  R  +++I+  RW+
Sbjct:   54 VGNYRLL-KTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQK-LFREVRIMKILNHPNIVKLFEVIETEKTLFLVMEYASGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCENLLKRFLVLNPGKRGTLEQIMRDRWI 308
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: MARK3 (microtubule affinity regulating kinase 3 [Source:HGNC Symbol;Acc:HGNC:6897])

HSP 1 Score: 199.134 bits (505), Expect = 1.160e-56
Identity = 108/273 (39.56%), Postives = 164/273 (60.07%), Query Frame = 3 
Query:  219 KIQSIGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            + Q +G Y+   +T+GKG+FA+V+L  H +T  +VA+KII+  ++    ++  L+RE RI+  LNHPNI+K +E +  +    L+ E + GG++ +Y+    + R  E  AR   RQ++SA+QY H+K +VHRDLK ENL+LD    ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C++L+K  L   P  R  +++I+  RW+
Sbjct:   61 QTQRVGNYRLL-KTIGKGNFAKVKLAKHTLTGQEVAVKIIDKTQLNTSSLQK-LFREVRIMKVLNHPNIVKLFEVIEMEKTLYLVMEYSSGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCENLLKRFLVLHPLKRGSLEQIMKDRWM 319
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006410.1 (pep scaffold:Pmarinus_7.0:GL476370:17405:31068:-1 gene:ENSPMAG00000005688.1 transcript:ENSPMAT00000006410.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 204.142 bits (518), Expect = 1.731e-56
Identity = 113/275 (41.09%), Postives = 165/275 (60.00%), Query Frame = 3 
Query:  213 GRKIQSIGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            G ++  IG Y+   +T+GKG+FA+V+L  H +T  +VA+KII+  ++    ++  L+RE RI+  LNHPNI+K YE +  +    L+ E A GG++ +Y+    + R  E  AR   RQ++SA+QY H+K +VHRDLK ENL+LD    H+K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF          Q L  +  K L  K+     ++ST+C++L+K  L   P  R  +++I+  RW+
Sbjct:   30 GEELPHIGNYRLL-KTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQK-LFREVRIMKCLNHPNIVKLYEVIETEKTLYLVMEYASGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYCHQKNIVHRDLKAENLLLD-VDMHIKIADFGFSNEFTLVNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELREKVLRGKYRIPF-YMSTDCENLLKRFLVLNPIKRGSLEQIMRDRWM 290
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: MARK3 (microtubule affinity regulating kinase 3 [Source:HGNC Symbol;Acc:HGNC:6897])

HSP 1 Score: 200.29 bits (508), Expect = 2.260e-54
Identity = 109/269 (40.52%), Postives = 162/269 (60.22%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            IG Y+   +T+GKG+FA+V+L  H +T  +VA+KII+  ++    ++  L+RE RI+  LNHPNI+K +E +  +    L+ E A GG++ +Y+    + R  E  AR   RQ++SA+QY H+K +VHRDLK ENL+LD    ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C++L+K  L   P  R  +++I+  RW+
Sbjct:   51 IGTYRLL-KTIGKGNFAKVKLARHTLTGREVAVKIIDKTQLNPSSLQK-LFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCENLLKRFLVLNPAKRGSLEQIMKDRWM 305
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: snrka (SNF related kinase a [Source:ZFIN;Acc:ZDB-GENE-040718-84])

HSP 1 Score: 167.162 bits (422), Expect = 5.056e-44
Identity = 101/275 (36.73%), Postives = 144/275 (52.36%), Query Frame = 3 
Query:  234 GKYKFCYE---TLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWVTNSD 1049
            GK    Y+   TLG+G FA V+L  H  T  KVA+K+I+  K+      +   +E R +  + HPN+++ YE +       LI E A GGDL +Y+   +     E++A+ Y  Q++ AI Y H   VVHRDLK EN++  + +  +KL DFG SN       L T CGS  Y+APE+   +    P VDIWS G++LY  V G  PF       A     L +I   +  K+T    H+S ECKDLI  +L+  P+ R  + E+  H W+   D
Sbjct:   10 GKIAGLYDLEKTLGRGHFAVVKLARHVFTGEKVAVKVIDKSKLDPMATSHLFQQEVRCMKLVQHPNVVRLYEVIDTQTKLYLILELADGGDLYDYIMRHE-GGLQEELAKTYFAQVVHAISYCHRLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNLFQPGTKLATSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILYMLVCGHPPF-----QEANDSETLTMI---MDCKYTVP-AHISRECKDLIARMLQRDPRRRASLQEMEGHPWLCGVD 274
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: NIM1K (NIM1 serine/threonine protein kinase [Source:HGNC Symbol;Acc:HGNC:28646])

HSP 1 Score: 153.68 bits (387), Expect = 6.336e-41
Identity = 94/279 (33.69%), Postives = 152/279 (54.48%), Query Frame = 3 
Query:  207 VMGRKIQSIGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQ--LNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            V+G++I     Y+   E +G G+F++V+L +H +T+ KVA+K+++  ++ E   R        IL+   L HPN+++ YE +       L+ E A GG+L  + +       P D A+    Q+ +A+++MHE GVVHRDLK EN+        +K+ DFG S  +  NE L T CGSP YAAPELF   +  GP+VD+W+ G++L+   +G LPF +   D   + +L ++   G  +   +    +   C +LI  +L PLP  R    +I+   W+
Sbjct:   35 VLGKRISF---YRIRGE-IGSGNFSQVKLGVHLLTRDKVAIKLLDKSRMDE---RTLCLLSCEILAMELLRHPNVVRLYEVVDTPSRLHLVMEYAPGGEL--FTRVSTVGALPHDEAKLVFAQITAAVKHMHECGVVHRDLKAENVFYAGNC-WVKVGDFGFSTTVTPNERLSTFCGSPPYAAPELFRDQSYLGPQVDVWALGVLLFFIASGTLPFRA---DTVGKLKLSIL--DGCFSVPLR----VPASCCNLITTILRPLPDERPTAAQILRSEWL 294
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: SNF1 (AMP-activated S/T protein kinase; forms a complex with Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis; regulates nucleocytoplasmic shuttling of Hxk2p; regulates filamentous growth and acts as a non-canonical GEF, activating Arf3p during invasive growth; SUMOylation by Mms21p inhibits its function and targets Snf1p for destruction via the Slx5-Slx8 Ub ligase [Source:SGD;Acc:S000002885])

HSP 1 Score: 169.088 bits (427), Expect = 1.116e-44
Identity = 103/268 (38.43%), Postives = 150/268 (55.97%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRW 1034
            IG Y+   +TLG+GSF +V+L  H  T  KVA+KIIN + + +  ++  + RE   L  L HP+IIK Y+ +++     ++ E A G +L +Y+   D  +  E  AR + +Q+ISA++Y H   +VHRDLK ENL+LD+   ++K+ DFGLSN +     L T CGSP YAAPE+ +     GPEVD+WS G++LY  +   LPF     D      L   I+ G+        + LS     LIK +L   P  RI + EI+   W
Sbjct:   52 IGNYQIV-KTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPHIIKLYDVIKSKDEIIMVIEYA-GNELFDYIVQRD--KMSEQEARRFFQQIISAVEYCHRHKIVHRDLKPENLLLDE-HLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYVMLCRRLPF-----DDESIPVLFKNISNGVYTLP----KFLSPGAAGLIKRMLIVNPLNRISIHEIMQDDW 305
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: KIN4 (Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication [Source:SGD;Acc:S000005759])

HSP 1 Score: 159.073 bits (401), Expect = 8.372e-41
Identity = 109/287 (37.98%), Postives = 156/287 (54.36%), Query Frame = 3 
Query:  216 RKIQSIGKYKFCYETLGKGSFARVEL------VIHEVTKCKVAMKIINTRKITEDYIRN-NLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNN-LPRNELLMTHCGSPEYAAPEL-FTTNALYGPEVDIWSFGIVLYACVTGDLPFF----SPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            RK  + G Y     TLG+G F +V+L        +EV K +VA+K+I    I +D  +   +YRE   L  L HPNII   E L+   Y  ++ E   GG+  +Y++    +R  E  A     QLIS + YMH KG+VHRDLK+ENL+LDK + +L + DFG  N     NEL+ T CGSP YAAPEL  +T A    + D+WS G++LYA + G LP+     +P  D   R      + K +T    K  E+++   +DL++ +L P P+ RI +  I  H W+
Sbjct:   38 RKHATFGPY-IIGSTLGEGEFGKVKLGWTKASSSNEVPK-QVAIKLIRRDTIKKDADKEIKIYREINALKHLTHPNIIYLEEVLQNSKYIGIVLEFVSGGEFYKYIQR--KRRLKESSACRLFAQLISGVNYMHYKGLVHRDLKLENLLLDKHE-NLVITDFGFVNEFFEDNELMKTSCGSPCYAAPELVVSTKAYEARKADVWSCGVILYAMLAGYLPWDDDHENPTGDDIAR------LYKYITQTPLKFPEYITPIPRDLLRRILVPNPRRRINLQTIKRHVWL 313
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: FRK1 (Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3p; FRK1 has a paralog, KIN4, that arose from the whole genome duplication [Source:SGD;Acc:S000006062])

HSP 1 Score: 152.91 bits (385), Expect = 1.104e-38
Identity = 107/292 (36.64%), Postives = 158/292 (54.11%), Query Frame = 3 
Query:  216 RKIQSIGKYKFCYETLGKGSFARVEL-----------VIHEVTKCKVAMKIINTRKITEDYIRN-NLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNL-PRNELLMTHCGSPEYAAPELFTTNALY-GPEVDIWSFGIVLYACVTGDLPF----FSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            RK  + G Y     TLG+G F +V+L              +  K +VA+K+I    I+ DY +   +YRE   L  L+HPNI+K  E L+   Y  ++ E A GG+  +Y++    +R  E  A     QLIS + Y+H KG+VHRDLK+ENL+LDK + +L + DFG  N    RNEL+ T CGSP YAAPEL  +   Y   + DIWS G++LYA + G LP+     +P  + +   RL   IN    +   K  +++    +DL++ +L   P+ RI + +I  H W+
Sbjct:   33 RKHVTFGPY-ILGSTLGEGEFGKVKLGWPKNFSNSSNSTFDFPK-QVAIKLIKRDSISNDYRKEVKIYREINALKHLSHPNIVKLEEVLQNSRYIGIVLEYACGGEFYKYIQ--KKRRLKEMNACRLFSQLISGVHYIHSKGLVHRDLKLENLLLDKNE-NLVITDFGFVNEFCSRNELMKTSCGSPCYAAPELVISAEPYEARKADIWSCGVILYAILAGYLPWDDDPNNP--EGSDIGRLYNYIN----STPLKFPDYILPIPRDLLRRMLVSDPKKRINLKQIKKHEWL 313
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: GIN4 (Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Hsl1p; GIN4 has a paralog, KCC4, that arose from the whole genome duplication [Source:SGD;Acc:S000002915])

HSP 1 Score: 152.91 bits (385), Expect = 1.705e-38
Identity = 98/284 (34.51%), Postives = 150/284 (52.82%), Query Frame = 3 
Query:  219 KIQSIGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKII-----NTRKI---------TEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINH 1028
            K  +IG +K   ETLG GS  +V+L  +  T  + A+K+I     NT  +         T D +   + RE  I+  LNHPN+++ Y+    +    L+ E A  G+L   +   +    PE  A  + RQ+I  + Y H  G+VHRDLK ENL+LD  K ++K+ DFG++      +LL T CGSP YAAPE+ +     G   D+WS G++L+A +TG LPF     +    + LL+ + KG     +   + +S E +DLI+ +L   P+ RI   +I+ H
Sbjct:   12 KDNTIGPWKLG-ETLGLGSTGKVQLARNGSTGQEAAVKVISKAVFNTGNVSGTSIVGSTTPDALPYGIEREIIIMKLLNHPNVLRLYDVWETNTDLYLVLEYAEKGELFNLL--VERGPLPEHEAIRFFRQIIIGVSYCHALGIVHRDLKPENLLLDH-KYNIKIADFGMAALETEGKLLETSCGSPHYAAPEIVSGIPYQGFASDVWSCGVILFALLTGRLPFDE---EDGNIRTLLLKVQKGEFEMPSD--DEISREAQDLIRKILTVDPERRIKTRDILKH 286
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: KIN1 (Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; KIN1 has a paralog, KIN2, that arose from the whole genome duplication [Source:SGD;Acc:S000002529])

HSP 1 Score: 150.599 bits (379), Expect = 6.909e-38
Identity = 96/297 (32.32%), Postives = 149/297 (50.17%), Query Frame = 3 
Query:  225 QSIGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIIN-------------------------TRKITEDYIRNN-LYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            +S+G ++F  ET+G GS  +V+L  H  T    A+KI+N                          +K+ ++  R+    REA +   L HP+I + +E      ++ ++ E   GG L +Y+    +    E  AR + R + SA+ Y+H   +VHRDLK+EN+M+  +   +K+IDFGLSN     + L T CGS  +AAPEL   N   GPEVD+WSFG+VL+  V G +PF     D      L   I +G      +  +HLS E   L+  +L   P+ R  + +++ H W+
Sbjct:  115 KSLGDWEFV-ETVGAGSMGKVKLAKHRYTNEVCAVKIVNRATKAFLHKEQMLPPPKNEQDVLERQKKLEKEISRDKRTIREASLGQILYHPHICRLFEMCTLSNHFYMLFEYVSGGQLLDYI--IQHGSIREHQARKFARGIASALIYLHANNIVHRDLKIENIMISDSSE-IKIIDFGLSNIYDSRKQLHTFCGSLYFAAPELLKANPYTGPEVDVWSFGVVLFVLVCGKVPF-----DDENSSVLHEKIKQG----KVEYPQHLSIEVISLLSKMLVVDPKRRATLKQVVEHHWM 398
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO46647 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RPA2])

HSP 1 Score: 204.912 bits (520), Expect = 1.673e-59
Identity = 114/283 (40.28%), Postives = 174/283 (61.48%), Query Frame = 3 
Query:  219 KIQSIGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITED-YIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNL---------PRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            K + +G Y    +T+G+GSFA+V+   H +T  KVA+KII+ ++  ED Y+  N+ REARIL  + HP+II   E +  +  Y L+ E A GGDL +Y+     KR  E   R ++RQ+ISA+QY+H+ G++HRDLK+ENL+LD+ + ++++IDFGLSN +         P  +   T CGSP YAAPE+   + LYG +VD+WS G+ +YA +TG LP+ +  ++      ++ + NK +  +     + LS  C+DL+   L   P  RI +DE INH W+
Sbjct:   18 KCKRVGNY-LLGKTIGEGSFAKVKQGFHVLTGEKVAVKIIDKKQALEDRYVSKNMRREARILQMVRHPHIISLLEVVETENRYYLVFELAGGGDLMDYICY--RKRLGETEVRKFIRQIISAVQYLHQGGIIHRDLKVENLLLDE-EYNIRIIDFGLSNTVSVAKPGDLSPIKDYCKTQCGSPAYAAPEIL-GHQLYGTKVDVWSIGVNMYAMLTGKLPYTAEPFN------IVTLYNKMVRGEMNAVPDRLSPSCRDLLMRFLTFDPDERISLDEAINHVWL 289
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO30768 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SZV3])

HSP 1 Score: 200.675 bits (509), Expect = 4.992e-55
Identity = 109/269 (40.52%), Postives = 162/269 (60.22%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            IG+Y+   +T+GKG+FA+V+L  H  T  +VA+KII+  ++    ++  L+RE RI+  L+HPNI+K YE +  D    L+ E A GG++ +Y+    + R  E  AR   RQ++SA+QY H+K V+HRDLK ENL+LD    ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C++L+K  L   PQ R  +++ +  +W+
Sbjct:   35 IGRYRLI-KTIGKGNFAKVKLAKHVPTGKEVAIKIIDKTQLNPSSLQK-LFREVRIMKFLDHPNIVKLYEVIETDKTLYLVMEYASGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYCHQKHVIHRDLKAENLLLD-ADMNIKIADFGFSNEFTPGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCENLLKKFLVLNPQKRARLEQTMTDKWM 289
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO46035 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RR22])

HSP 1 Score: 184.496 bits (467), Expect = 3.186e-52
Identity = 105/262 (40.08%), Postives = 156/262 (59.54%), Query Frame = 3 
Query:  255 ETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWVT 1040
            +T+GKG+FA V+L  H +TK KVA+KII+  ++ +D +   + RE +++ +L HP+IIK +E +  +    L+TE A  G++ +Y+    + R  E  A+    Q++SAI+Y H+  +VHRDLK ENL+LD+   ++K+ DFG SN    ++ L T CGSP YAAPELF      GPEVDIWS G+VLY  V G LPF     D +  Q L   +  G      +    +STEC+ LI+ +L   P  R  + +I  H+W+ 
Sbjct:   24 KTIGKGNFAVVKLATHCITKSKVAVKIIDKSQLDDDNL-TKVKREVKVMKKLAHPHIIKLHEVMETERMLYLVTEYASKGEIFDYLVA--HGRMQEKEAKNTFNQIVSAIEYCHKMNIVHRDLKAENLLLDED-MNIKIADFGFSNIFQADKKLKTWCGSPPYAAPELFEGKEYLGPEVDIWSLGVVLYVLVCGALPF-----DGSTLQSLRSRVLDG----RFRIPFFMSTECEHLIRHMLVRDPVKRFTIPQIRQHKWMA 272
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO36587 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SI81])

HSP 1 Score: 182.57 bits (462), Expect = 2.119e-51
Identity = 114/336 (33.93%), Postives = 177/336 (52.68%), Query Frame = 3 
Query:  225 QSIGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWVTNSDQIXXXXXXXXXXXXELKSQ----IIEKLAEFTSLNKTEIERFVHENGTNELSAMFKMLLEE 1220
            Q  G Y    ETLG+G FA V++  H +T  +VA+K+I+  K+ E   R +L +E R +  + HPN+++ Y+ +  +    LI E   GGD+ +Y+   D K  PE+ ARY+ RQ++ AI Y H+  VVHRDLK EN++  K +   KL DFG SNN   NE L T CGS  Y+APE+   +A   P VD+WS G++LY  V G  PF       A     L    K +  ++    +H+S  CK+LI  +L   P  R  + EI++H W+            P      L +     +++K+ +    ++ ++ R + EN  +  +A + +L E+
Sbjct:   14 QIAGMYDLG-ETLGRGHFAVVKVARHVITGERVAVKVIDKTKLDE-VSREHLLKEVRCMKLVQHPNVVRLYQVIDTNTKLYLILELGDGGDMYDYIMNHD-KGLPEEKARYFFRQIVLAIDYCHKLHVVHRDLKPENVIFFKNQDMAKLTDFGFSNNFIPNEKLDTACGSLAYSAPEVLLGDAYEAPAVDVWSLGVILYMLVCGQAPF-----SEANDSETL---TKIMDCRYDVP-DHVSPLCKNLISRMLIREPHNRASLGEIMSHPWLQQGPTPLVPSDVPLVAELPLTTDEHLLLLDKMEDGNIADRDKVIRSLEENSYDFTAATYFLLAEQ 337
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO47961 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RKT6])

HSP 1 Score: 174.866 bits (442), Expect = 1.363e-49
Identity = 100/259 (38.61%), Postives = 146/259 (56.37%), Query Frame = 3 
Query:  261 LGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            LG+G+FA+V+L   +   C VA+KII+ RK  +DYI   L RE R++ +LNHPN+I+ YE++  +    LI E A GGDL EY+        PE+ AR    Q ++ + Y H++ VVHRDLK ENL+LD   R LK+ DFG + N  +  +L T CGS  Y +PE+   +   G   DIWS G+VLYA V   LPF            L  I+N+    +  +  +  S EC++LI+ +L    + R   +E+++  W 
Sbjct:   14 LGEGAFAKVKLAKSKKHNCHVAIKIIDKRKAPKDYIYKFLPREIRVMHKLNHPNVIQLYEAIETETKVYLILELAEGGDLLEYINKNAL--LPEERARVIFCQFVATMAYCHKERVVHRDLKCENLLLDANGR-LKITDFGFACNTHKTNILQTFCGSYAYCSPEILRGDLYDGQASDIWSMGVVLYALVCARLPFGD--------DDLRAIMNR--EPRKLRFSKKTSKECRELIRKMLALDEKKRPTAEELLHEPWC 259
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: mark3a (microtubule affinity regulating kinase 3 [Source:NCBI gene;Acc:101163781])

HSP 1 Score: 202.601 bits (514), Expect = 4.217e-55
Identity = 109/269 (40.52%), Postives = 163/269 (60.59%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            +G Y+   +T+GKG+FA+V+L  H +T  +VA+KII+  ++  + ++  L+RE RI+  LNHPNI+K +E +  D    L+ E A GG++ +Y+    + R  E  AR   RQ++SA+QY H+K +VHRDLK ENL+LD    ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C++L+K  L   P  R  +++I+  RW+
Sbjct:   50 VGNYRLL-KTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPNSLQK-LFREVRIMKILNHPNIVKLFEVIETDRTLYLVMEYASGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTLGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCENLLKRFLVLNPAKRGTLEQIMKDRWI 304
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: mark3a (microtubule affinity regulating kinase 3 [Source:NCBI gene;Acc:101163781])

HSP 1 Score: 202.601 bits (514), Expect = 4.269e-55
Identity = 109/269 (40.52%), Postives = 163/269 (60.59%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            +G Y+   +T+GKG+FA+V+L  H +T  +VA+KII+  ++  + ++  L+RE RI+  LNHPNI+K +E +  D    L+ E A GG++ +Y+    + R  E  AR   RQ++SA+QY H+K +VHRDLK ENL+LD    ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C++L+K  L   P  R  +++I+  RW+
Sbjct:   50 VGNYRLL-KTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPNSLQK-LFREVRIMKILNHPNIVKLFEVIETDRTLYLVMEYASGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTLGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCENLLKRFLVLNPAKRGTLEQIMKDRWI 304
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: mark3a (microtubule affinity regulating kinase 3 [Source:NCBI gene;Acc:101163781])

HSP 1 Score: 202.216 bits (513), Expect = 1.185e-54
Identity = 109/269 (40.52%), Postives = 163/269 (60.59%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            +G Y+   +T+GKG+FA+V+L  H +T  +VA+KII+  ++  + ++  L+RE RI+  LNHPNI+K +E +  D    L+ E A GG++ +Y+    + R  E  AR   RQ++SA+QY H+K +VHRDLK ENL+LD    ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C++L+K  L   P  R  +++I+  RW+
Sbjct:   50 VGNYRLL-KTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPNSLQK-LFREVRIMKILNHPNIVKLFEVIETDRTLYLVMEYASGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTLGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCENLLKRFLVLNPAKRGTLEQIMKDRWI 304
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: mark3a (microtubule affinity regulating kinase 3 [Source:NCBI gene;Acc:101163781])

HSP 1 Score: 201.83 bits (512), Expect = 1.429e-54
Identity = 109/269 (40.52%), Postives = 163/269 (60.59%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            +G Y+   +T+GKG+FA+V+L  H +T  +VA+KII+  ++  + ++  L+RE RI+  LNHPNI+K +E +  D    L+ E A GG++ +Y+    + R  E  AR   RQ++SA+QY H+K +VHRDLK ENL+LD    ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C++L+K  L   P  R  +++I+  RW+
Sbjct:   50 VGNYRLL-KTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPNSLQK-LFREVRIMKILNHPNIVKLFEVIETDRTLYLVMEYASGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTLGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCENLLKRFLVLNPAKRGTLEQIMKDRWI 304
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: mark3a (microtubule affinity regulating kinase 3 [Source:NCBI gene;Acc:101163781])

HSP 1 Score: 201.83 bits (512), Expect = 1.431e-54
Identity = 109/269 (40.52%), Postives = 163/269 (60.59%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            +G Y+   +T+GKG+FA+V+L  H +T  +VA+KII+  ++  + ++  L+RE RI+  LNHPNI+K +E +  D    L+ E A GG++ +Y+    + R  E  AR   RQ++SA+QY H+K +VHRDLK ENL+LD    ++K+ DFG SN       L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C++L+K  L   P  R  +++I+  RW+
Sbjct:   50 VGNYRLL-KTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPNSLQK-LFREVRIMKILNHPNIVKLFEVIETDRTLYLVMEYASGGEVFDYL--VAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTLGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLKELRERVLRGKYRIPF-YMSTDCENLLKRFLVLNPAKRGTLEQIMKDRWI 304
[Close]
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000005514.1 (SMESG000005514.1)

HSP 1 Score: 1204.12 bits (3114), Expect = 0.000e+0
Identity = 667/668 (99.85%), Postives = 668/668 (100.00%), Query Frame = 3 
Query:  210 MGRKIQSIGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWVTNSDQIXXXXXXXXXXXXELKSQIIEKLAEFTSLNKTEIERFVHENGTNELSAMFKMLLEETKVEMGYYEEDHTNRPLSVVNERKRQXXXXXXXXXXXXXXESARIFRELINSKQQSNGAGKSESFDNKDKAIFQASDXXXXXXXXXXXXXXXGIVKTXXXXXXXXXXRSAMQPAISVESNRSLTQLKNIRSRVPNSETISNQISLPVLSDPSPKRCNSLIPSQRKVTSNPPNLQNDMSCSNKDISRTLKSNSAEKKPQSVPSELSHKSTYRSTQKNLNVDLPKVPLANINEVYMDNLETTSNIDFSEPRYCLVKVTXXXXXXXXXXXXXXXXXXXXXXMNSFNLENAVDNLEVNDSKNEDTTDSGTPTTVICSQTDSHHLCNGDIPANDLL 2213
            MGRKIQSIGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWVTNSDQIPFTPYFPKPKPPELKSQIIEKLAEFTSLNKTEIERFVHENGTNELSAMFKMLLEETKVEMGYYEEDHTNRPLSVVNERKRQLARLKWRKLRYRLKESARIFRELINSKQQSNGAGKSESFDNKDKAIFQASDPRPNKVKVKPRVNPVGIVKTEKKKEFFPPKRSAMQPAISVESNRSLTQLKNIRSRVPNSETISNQISLPVLSDPSPKRCNSLIPSQRKVTSNPPNLQNDMSCSNKDISRTLKSNSAEKKPQSVPSELSHKSTYRSTQKNLNVDLPKVPLANINEVYMDNLETTSNIDFSEPRYCLVKVTESDLSSGLLISSTISEISEGRSMNSFNLENAVDNLEVNDSKNEDTTDSGTPTTVICSQT+SHHLCNGDIPANDLL
Sbjct:    1 MGRKIQSIGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWVTNSDQIPFTPYFPKPKPPELKSQIIEKLAEFTSLNKTEIERFVHENGTNELSAMFKMLLEETKVEMGYYEEDHTNRPLSVVNERKRQLARLKWRKLRYRLKESARIFRELINSKQQSNGAGKSESFDNKDKAIFQASDPRPNKVKVKPRVNPVGIVKTEKKKEFFPPKRSAMQPAISVESNRSLTQLKNIRSRVPNSETISNQISLPVLSDPSPKRCNSLIPSQRKVTSNPPNLQNDMSCSNKDISRTLKSNSAEKKPQSVPSELSHKSTYRSTQKNLNVDLPKVPLANINEVYMDNLETTSNIDFSEPRYCLVKVTESDLSSGLLISSTISEISEGRSMNSFNLENAVDNLEVNDSKNEDTTDSGTPTTVICSQTNSHHLCNGDIPANDLL 668
[Close]
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000005514.1 (SMESG000005514.1)

HSP 1 Score: 1120.92 bits (2898), Expect = 0.000e+0
Identity = 628/629 (99.84%), Postives = 629/629 (100.00%), Query Frame = 3 
Query:  327 MKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWVTNSDQIXXXXXXXXXXXXELKSQIIEKLAEFTSLNKTEIERFVHENGTNELSAMFKMLLEETKVEMGYYEEDHTNRPLSVVNERKRQXXXXXXXXXXXXXXESARIFRELINSKQQSNGAGKSESFDNKDKAIFQASDXXXXXXXXXXXXXXXGIVKTXXXXXXXXXXRSAMQPAISVESNRSLTQLKNIRSRVPNSETISNQISLPVLSDPSPKRCNSLIPSQRKVTSNPPNLQNDMSCSNKDISRTLKSNSAEKKPQSVPSELSHKSTYRSTQKNLNVDLPKVPLANINEVYMDNLETTSNIDFSEPRYCLVKVTXXXXXXXXXXXXXXXXXXXXXXMNSFNLENAVDNLEVNDSKNEDTTDSGTPTTVICSQTDSHHLCNGDIPANDLL 2213
            MKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWVTNSDQIPFTPYFPKPKPPELKSQIIEKLAEFTSLNKTEIERFVHENGTNELSAMFKMLLEETKVEMGYYEEDHTNRPLSVVNERKRQLARLKWRKLRYRLKESARIFRELINSKQQSNGAGKSESFDNKDKAIFQASDPRPNKVKVKPRVNPVGIVKTEKKKEFFPPKRSAMQPAISVESNRSLTQLKNIRSRVPNSETISNQISLPVLSDPSPKRCNSLIPSQRKVTSNPPNLQNDMSCSNKDISRTLKSNSAEKKPQSVPSELSHKSTYRSTQKNLNVDLPKVPLANINEVYMDNLETTSNIDFSEPRYCLVKVTESDLSSGLLISSTISEISEGRSMNSFNLENAVDNLEVNDSKNEDTTDSGTPTTVICSQT+SHHLCNGDIPANDLL
Sbjct:    1 MKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWVTNSDQIPFTPYFPKPKPPELKSQIIEKLAEFTSLNKTEIERFVHENGTNELSAMFKMLLEETKVEMGYYEEDHTNRPLSVVNERKRQLARLKWRKLRYRLKESARIFRELINSKQQSNGAGKSESFDNKDKAIFQASDPRPNKVKVKPRVNPVGIVKTEKKKEFFPPKRSAMQPAISVESNRSLTQLKNIRSRVPNSETISNQISLPVLSDPSPKRCNSLIPSQRKVTSNPPNLQNDMSCSNKDISRTLKSNSAEKKPQSVPSELSHKSTYRSTQKNLNVDLPKVPLANINEVYMDNLETTSNIDFSEPRYCLVKVTESDLSSGLLISSTISEISEGRSMNSFNLENAVDNLEVNDSKNEDTTDSGTPTTVICSQTNSHHLCNGDIPANDLL 629
[Close]
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000055722.1 (SMESG000055722.1)

HSP 1 Score: 211.846 bits (538), Expect = 2.793e-57
Identity = 111/269 (41.26%), Postives = 164/269 (60.97%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            +GKYKF   T+GKG+FA+V+L  H +T+ +VA+KII+   +     +  L RE +I+  LNHPNI+K +E +  D    L+ E A GG++ +Y+    + R  E  AR   RQ++SA+QY H+K +VHRDLK ENL+LDK + ++K+ DFG SN     + L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C+ L++ +L   PQ R  ++ ++  RW+
Sbjct:   52 VGKYKFI-RTIGKGNFAKVKLAKHVITQKEVAIKIIDKSHLNPSS-KQKLNREVKIMKCLNHPNIVKLFEIIENDKILYLVMEYASGGEVFDYL--VAHGRMKEKEARLKFRQIVSAVQYCHQKKIVHRDLKAENLLLDK-EMNIKIADFGFSNEFKPGDKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLRDLRERVLKGKYRIPF-YMSTDCESLLRKMLVLNPQKRYSLEAVMKDRWM 306
[Close]
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000055722.1 (SMESG000055722.1)

HSP 1 Score: 211.846 bits (538), Expect = 3.099e-57
Identity = 111/269 (41.26%), Postives = 164/269 (60.97%), Query Frame = 3 
Query:  231 IGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            +GKYKF   T+GKG+FA+V+L  H +T+ +VA+KII+   +     +  L RE +I+  LNHPNI+K +E +  D    L+ E A GG++ +Y+    + R  E  AR   RQ++SA+QY H+K +VHRDLK ENL+LDK + ++K+ DFG SN     + L T CGSP YAAPELF      GPEVD+WS G++LY  V+G LPF          Q L  +  + L  K+     ++ST+C+ L++ +L   PQ R  ++ ++  RW+
Sbjct:   52 VGKYKFI-RTIGKGNFAKVKLAKHVITQKEVAIKIIDKSHLNPSS-KQKLNREVKIMKCLNHPNIVKLFEIIENDKILYLVMEYASGGEVFDYL--VAHGRMKEKEARLKFRQIVSAVQYCHQKKIVHRDLKAENLLLDK-EMNIKIADFGFSNEFKPGDKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--------QNLRDLRERVLKGKYRIPF-YMSTDCESLLRKMLVLNPQKRYSLEAVMKDRWM 306
[Close]
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000042362.1 (SMESG000042362.1)

HSP 1 Score: 206.068 bits (523), Expect = 5.729e-55
Identity = 111/274 (40.51%), Postives = 165/274 (60.22%), Query Frame = 3 
Query:  216 RKIQSIGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITEDYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEYMKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKRHLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFGIVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECKDLIKDVLEPLPQLRIPMDEIINHRWV 1037
            R   + GKYK   E +GKG+FA+V+L  H +T  +VA+KII+  K+    ++  L RE +I+ +LNHPNI++ YE ++ +    L+ E A  G++ EY+      R  E  AR   RQ++SA+QY H+K +VHRDLK ENL+LDK    +K+ DFG SN+  R   L T CGSP YAAPELF      GPEVD+WS G++LY  ++G LPF     D    + L   +   L  K+     ++S++C+ L++ +L   PQ R+P+ +I+   W+
Sbjct:  125 RNGPTFGKYKLIRE-IGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQK-LTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYL--VKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDK-DLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPF-----DGGTLRELRERV---LRGKYRIPF-YMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWI 384
The following BLAST results are available for this feature:
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
MARK25.797e-5440.52microtubule affinity regulating kinase 2 [Source:H... [more]
MARK26.440e-5440.52microtubule affinity regulating kinase 2 [Source:H... [more]
MARK27.253e-5440.52microtubule affinity regulating kinase 2 [Source:H... [more]
MARK28.922e-5440.52microtubule affinity regulating kinase 2 [Source:H... [more]
MARK29.325e-5440.52microtubule affinity regulating kinase 2 [Source:H... [more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
par-19.417e-6037.83Serine/threonine-protein kinase par-1 [Source:Uni... [more]
par-19.417e-6037.83Serine/threonine-protein kinase par-1 [Source:Uni... [more]
par-19.417e-6037.83Serine/threonine-protein kinase par-1 [Source:Uni... [more]
par-19.417e-6037.83Serine/threonine-protein kinase par-1 [Source:Uni... [more]
par-19.417e-6037.83Serine/threonine-protein kinase par-1 [Source:Uni... [more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
par-17.860e-5339.78gene:FBgn0260934 transcript:FBtr0301505[more]
par-18.274e-5339.78gene:FBgn0260934 transcript:FBtr0330243[more]
par-19.978e-5339.78gene:FBgn0260934 transcript:FBtr0100390[more]
par-12.692e-5239.78gene:FBgn0260934 transcript:FBtr0086457[more]
par-13.262e-5239.78gene:FBgn0260934 transcript:FBtr0086450[more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
mark3a2.510e-5439.34MAP/microtubule affinity-regulating kinase 3a [Sou... [more]
mark2b2.550e-5440.52MAP/microtubule affinity-regulating kinase 2b [Sou... [more]
mark2b3.254e-5440.52MAP/microtubule affinity-regulating kinase 2b [Sou... [more]
mark2b3.658e-5440.52MAP/microtubule affinity-regulating kinase 2b [Sou... [more]
mark3b6.083e-5440.89MAP/microtubule affinity-regulating kinase 3b [Sou... [more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSXETT00000045307.11.843e-5734.97MAP/microtubule affinity-regulating kinase 4 [Sour... [more]
ENSXETT00000045494.13.712e-5734.97MAP/microtubule affinity-regulating kinase 4 [Sour... [more]
ENSXETT00000045259.15.823e-5734.97MAP/microtubule affinity-regulating kinase 4 [Sour... [more]
ENSXETT00000045413.18.192e-5635.12MAP/microtubule affinity-regulating kinase 4 [Sour... [more]
ENSXETT00000045600.18.640e-5635.12MAP/microtubule affinity-regulating kinase 4 [Sour... [more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Mark25.128e-5440.52MAP/microtubule affinity regulating kinase 2 [Sour... [more]
Mark25.225e-5440.52MAP/microtubule affinity regulating kinase 2 [Sour... [more]
Mark26.065e-5440.52MAP/microtubule affinity regulating kinase 2 [Sour... [more]
Mark27.455e-5440.52MAP/microtubule affinity regulating kinase 2 [Sour... [more]
Mark38.447e-5440.89MAP/microtubule affinity regulating kinase 3 [Sour... [more]
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BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q9TW45|PAR1_CAEEL2.051e-5837.83Serine/threonine-protein kinase par-1 OS=Caenorhab... [more]
sp|A8WYE4|PAR1_CAEBR4.427e-5837.65Serine/threonine-protein kinase par-1 OS=Caenorhab... [more]
sp|Q05512|MARK2_MOUSE3.952e-5340.52Serine/threonine-protein kinase MARK2 OS=Mus muscu... [more]
sp|O08679|MARK2_RAT4.828e-5340.52Serine/threonine-protein kinase MARK2 OS=Rattus no... [more]
sp|Q03141|MARK3_MOUSE8.961e-5340.89MAP/microtubule affinity-regulating kinase 3 OS=Mu... [more]
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BLAST of Protein kinase domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A210QK577.848e-12654.11Serine/threonine-protein kinase par-1 OS=Mizuhopec... [more]
A0A1S3IJZ41.160e-12555.43serine/threonine-protein kinase MARK2 isoform X1 O... [more]
A0A2C9JHR75.544e-11452.00Protein kinase domain-containing protein OS=Biomph... [more]
A0A2C9JHR59.028e-11149.72Protein kinase domain-containing protein OS=Biomph... [more]
A0A2C9JHR62.542e-11049.72Protein kinase domain-containing protein OS=Biomph... [more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
mark3a1.031e-5540.15microtubule affinity regulating kinase 3 [Source:N... [more]
mark3a1.247e-5540.15microtubule affinity regulating kinase 3 [Source:N... [more]
mark3a6.043e-5540.15microtubule affinity regulating kinase 3 [Source:N... [more]
mark3a6.635e-5540.15microtubule affinity regulating kinase 3 [Source:N... [more]
mark3a1.054e-5440.15microtubule affinity regulating kinase 3 [Source:N... [more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
MARK31.160e-5639.56microtubule affinity regulating kinase 3 [Source:H... [more]
ENSPMAT00000006410.11.731e-5641.09pep scaffold:Pmarinus_7.0:GL476370:17405:31068:-1 ... [more]
MARK32.260e-5440.52microtubule affinity regulating kinase 3 [Source:H... [more]
snrka5.056e-4436.73SNF related kinase a [Source:ZFIN;Acc:ZDB-GENE-040... [more]
NIM1K6.336e-4133.69NIM1 serine/threonine protein kinase [Source:HGNC ... [more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5
Match NameE-valueIdentityDescription
SNF11.116e-4438.43AMP-activated S/T protein kinase; forms a complex ... [more]
KIN48.372e-4137.98Serine/threonine protein kinase; inhibits the mito... [more]
FRK11.104e-3836.64Protein kinase of unknown cellular role; green flu... [more]
GIN41.705e-3834.51Protein kinase involved in bud growth and assembly... [more]
KIN16.909e-3832.32Serine/threonine protein kinase involved in regula... [more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO466471.673e-5940.28Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO307684.992e-5540.52Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO460353.186e-5240.08Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO365872.119e-5133.93Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO479611.363e-4938.61Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
mark3a4.217e-5540.52microtubule affinity regulating kinase 3 [Source:N... [more]
mark3a4.269e-5540.52microtubule affinity regulating kinase 3 [Source:N... [more]
mark3a1.185e-5440.52microtubule affinity regulating kinase 3 [Source:N... [more]
mark3a1.429e-5440.52microtubule affinity regulating kinase 3 [Source:N... [more]
mark3a1.431e-5440.52microtubule affinity regulating kinase 3 [Source:N... [more]
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BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000005514.10.000e+099.85SMESG000005514.1[more]
SMESG000005514.10.000e+099.84SMESG000005514.1[more]
SMESG000055722.12.793e-5741.26SMESG000055722.1[more]
SMESG000055722.13.099e-5741.26SMESG000055722.1[more]
SMESG000042362.15.729e-5540.51SMESG000042362.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30031370 ID=SMED30031370|Name=Protein kinase domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=2365bp
CTCGTATTATCTCACCCGATAACAGATGGACACTATTTCGTTTGTTTCAA
TTATTCTCGACTTAGAATTCAGTGTTAGATTCGCATAACAATTTGTTACA
ATCCATTCGAATTTCCACCACAATATATTTCTGTTGATTTCGATTTCGGT
TTTTTCAGTTGTTTTTATATTGATCTTTCTCATTTCTCCTAAATATTGAT
TTCTTTGTGATGGGTCGAAAAATTCAATCGATTGGAAAATATAAATTTTG
CTACGAAACACTCGGAAAAGGATCTTTTGCCCGCGTGGAGCTGGTTATCC
ACGAAGTAACTAAATGTAAAGTAGCTATGAAAATTATTAATACAAGGAAA
ATAACCGAAGATTACATCCGTAATAATCTGTATAGAGAAGCTAGAATTCT
CTCTCAACTCAATCATCCTAATATAATAAAGTTCTACGAATCTTTAAGGG
CCGATATTTATTATTGTTTAATAACTGAATGTGCTCACGGTGGTGATCTT
GCCGAGTACATGAAAACATTTGACTACAAAAGATTTCCTGAAGATGTAGC
ACGATATTATTTGCGGCAACTCATTTCGGCCATTCAATATATGCATGAGA
AAGGAGTTGTTCACAGGGATTTGAAAATGGAGAATTTAATGCTCGACAAA
ACAAAAAGACATCTCAAACTCATTGATTTCGGATTGAGTAATAACTTGCC
TAGGAATGAACTACTAATGACCCACTGTGGGTCTCCTGAATATGCAGCTC
CGGAATTATTTACTACAAATGCTCTCTATGGACCTGAAGTCGATATTTGG
AGCTTTGGAATTGTTTTGTACGCTTGTGTCACCGGAGATCTGCCATTTTT
CAGTCCATATTATGATCATGCAAGGAGACAGAGACTGTTAGTCATAATCA
ACAAAGGTCTCACGGCTAAACATACAAAAGAAATGGAACATCTTTCAACC
GAATGCAAAGATTTGATAAAAGATGTACTCGAGCCCCTGCCACAACTCCG
AATTCCGATGGATGAAATCATAAATCATCGATGGGTAACAAACAGTGACC
AGATCCCATTCACACCTTATTTCCCAAAGCCAAAGCCACCGGAATTAAAA
TCTCAAATTATCGAGAAGTTAGCCGAATTCACCAGTTTGAACAAAACAGA
AATCGAAAGATTTGTCCATGAAAATGGAACCAATGAACTATCAGCCATGT
TTAAAATGCTGCTCGAAGAAACCAAAGTTGAAATGGGATATTACGAGGAA
GATCACACAAACAGACCACTGAGCGTGGTTAATGAACGGAAACGTCAATT
AGCCAGATTAAAGTGGCGTAAACTCAGATATAGATTGAAAGAAAGTGCTA
GAATTTTCAGAGAGCTGATTAATAGCAAGCAACAGTCCAATGGAGCAGGA
AAATCTGAAAGTTTTGATAATAAAGATAAAGCAATTTTTCAAGCAAGCGA
CCCTAGACCTAATAAGGTAAAAGTAAAGCCAAGAGTTAATCCTGTTGGAA
TTGTTAAAACAGAAAAGAAAAAAGAATTTTTCCCTCCTAAGCGAAGTGCA
ATGCAACCAGCAATATCAGTTGAAAGTAACAGATCTCTAACTCAACTGAA
AAACATTCGTTCTCGAGTTCCGAATTCCGAAACTATAAGTAACCAAATAT
CACTGCCTGTTCTCAGTGACCCAAGTCCAAAACGCTGTAACAGTCTTATA
CCTTCTCAAAGAAAGGTTACATCAAATCCTCCTAACTTGCAAAATGATAT
GTCGTGTTCCAATAAGGATATTTCACGAACTTTGAAATCTAATTCAGCAG
AAAAGAAACCTCAATCAGTTCCATCCGAACTTTCTCACAAGTCCACATAT
CGCTCAACTCAAAAGAATTTAAATGTAGATCTTCCCAAAGTGCCACTGGC
GAATATAAATGAAGTTTATATGGATAATTTGGAAACGACTTCGAATATAG
ATTTCAGTGAACCAAGATATTGTTTGGTGAAAGTAACTGAAAGTGATCTA
TCTAGTGGATTATTAATATCAAGCACAATTTCTGAGATCAGTGAAGGCAG
ATCAATGAATTCTTTCAACTTGGAGAATGCCGTAGATAATCTGGAAGTAA
ACGATTCGAAAAATGAAGATACGACAGACAGTGGAACCCCGACTACCGTC
ATTTGCTCACAGACTGACAGCCATCACTTATGCAATGGTGATATTCCAGC
CAATGATTTGTTATAAAAACCCGTATATGTCATTTGAAAGCTTTTATGTT
TCTATGTTTGTTGAACAAAATGATTGTTATTTTCATTGAATTTTCTTTGA
AGATTTCAGATGAAAAATATTTTAAGTTGTATCACCAAAATGTATTATTT
CTGATTTCCTTATAT
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protein sequence of SMED30031370-orf-1

>SMED30031370-orf-1 ID=SMED30031370-orf-1|Name=SMED30031370-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=669bp
MGRKIQSIGKYKFCYETLGKGSFARVELVIHEVTKCKVAMKIINTRKITE
DYIRNNLYREARILSQLNHPNIIKFYESLRADIYYCLITECAHGGDLAEY
MKTFDYKRFPEDVARYYLRQLISAIQYMHEKGVVHRDLKMENLMLDKTKR
HLKLIDFGLSNNLPRNELLMTHCGSPEYAAPELFTTNALYGPEVDIWSFG
IVLYACVTGDLPFFSPYYDHARRQRLLVIINKGLTAKHTKEMEHLSTECK
DLIKDVLEPLPQLRIPMDEIINHRWVTNSDQIPFTPYFPKPKPPELKSQI
IEKLAEFTSLNKTEIERFVHENGTNELSAMFKMLLEETKVEMGYYEEDHT
NRPLSVVNERKRQLARLKWRKLRYRLKESARIFRELINSKQQSNGAGKSE
SFDNKDKAIFQASDPRPNKVKVKPRVNPVGIVKTEKKKEFFPPKRSAMQP
AISVESNRSLTQLKNIRSRVPNSETISNQISLPVLSDPSPKRCNSLIPSQ
RKVTSNPPNLQNDMSCSNKDISRTLKSNSAEKKPQSVPSELSHKSTYRST
QKNLNVDLPKVPLANINEVYMDNLETTSNIDFSEPRYCLVKVTESDLSSG
LLISSTISEISEGRSMNSFNLENAVDNLEVNDSKNEDTTDSGTPTTVICS
QTDSHHLCNGDIPANDLL*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000099neuron
PLANA:0000418head
Vocabulary: INTERPRO
TermDefinition
IPR000719Prot_kinase_dom
IPR017441Protein_kinase_ATP_BS
IPR008271Ser/Thr_kinase_AS
IPR011009Kinase-like_dom_sf
Vocabulary: biological process
TermDefinition
GO:0006468protein phosphorylation
GO:0016310phosphorylation
Vocabulary: molecular function
TermDefinition
GO:0005524ATP binding
GO:0004672protein kinase activity
GO:0016301kinase activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000719Protein kinase domainSMARTSM00220serkin_6coord: 12..276
e-value: 1.6E-87
score: 306.7
IPR000719Protein kinase domainPFAMPF00069Pkinasecoord: 16..276
e-value: 2.2E-68
score: 230.5
IPR000719Protein kinase domainPROSITEPS50011PROTEIN_KINASE_DOMcoord: 12..276
score: 46.944
NoneNo IPR availableGENE3DG3DSA:1.10.510.10coord: 4..355
e-value: 7.2E-87
score: 293.7
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 498..517
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 525..553
NoneNo IPR availablePANTHERPTHR24346MAP/MICROTUBULE AFFINITY-REGULATING KINASEcoord: 5..550
NoneNo IPR availablePANTHERPTHR24346:SF30NON-SPECIFIC SERINE/THREONINE PROTEIN KINASEcoord: 5..550
NoneNo IPR availableCDDcd14003STKc_AMPK-likecoord: 16..275
e-value: 2.81697E-99
score: 302.514
IPR017441Protein kinase, ATP binding sitePROSITEPS00107PROTEIN_KINASE_ATPcoord: 18..41
IPR008271Serine/threonine-protein kinase, active sitePROSITEPS00108PROTEIN_KINASE_STcoord: 133..145
IPR011009Protein kinase-like domain superfamilySUPERFAMILYSSF56112Protein kinase-like (PK-like)coord: 15..299