F-box domain-containing protein
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30031271 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 1
Homology
BLAST of F-box domain-containing protein vs. TrEMBL
Match: A0A095AL26 (F-box domain-containing protein OS=Schistosoma haematobium OX=6185 GN=MS3_03007 PE=4 SV=1) HSP 1 Score: 94.3597 bits (233), Expect = 2.095e-17 Identity = 95/334 (28.44%), Postives = 150/334 (44.91%), Query Frame = 2 Query: 26 KMKIRFKYQKKFLIFSMDEIDPTVKQIILGAADKFDLNANNVEISLNANDYYDSENYGSQRASELKIVNGDIIHVRLNGLYDDIKNIVKQEIAYKLEEVL--ECSNVTYKSPTLLKLLIPIHLFMSETGFSMRNDGRPFLQFVLDSFHSEASSDEIPKLMRLVY-FLFKDSFTVNLTIYYTEPHVCIYGS---YPESKSIYFYN---FKSKDFILQN---------QARNAF---------NKADFVYKNLLQFSNSFKNSIAVPLRIDICLSKFIPTHSFFQVLPYEIIHRILEYLDIKSILSVMSTCQRLNEAGRFCSTIWLRRLLKSTGKN 946 KM++R K+ KF +F T+ +I A+ F L NV+ISLNA DYY+ NY +Q SEL IVNGDII++ DDIK ++ E+A + + + SN + + TLL + IP+++F E G + LD H E+ ++RL + + DS + T++ CI S P K + +D I Q+ ++F NK + +Y++L S K+ + P+ + I + LP E+ IL YL + S+ +M + L+ R C+T+W L K KN Sbjct: 46 KMRLRLKFLNKFHVFETATASATLNEIFESASKIFSLKRENVQISLNAKDYYNI-NYSNQSLSELGIVNGDIIYINSLEKLDDIKQSLETELATPILKFINDNLSNDQHYTSTLL-MAIPLYIFAIEKGL-----------YTLD--HLSQYYQEMSSIIRLTFNYPQVDSIKLIFTLFQNGNMTCIAASVQDLPIRKQLILQTKLYLIKQDTIHQSCIFSNNLLFVCLSSFVCMLNLATTNKLNLLYRHLRLLSIRIKDELIEPILLAIHSEYNLSPRLHLCTLPSELFCEILCYLRLTSLGFLMLCNRELSYRIRNCNTVWRIHLAKLNAKN 364
BLAST of F-box domain-containing protein vs. TrEMBL
Match: A0A4S2LHB0 (F-box domain-containing protein OS=Opisthorchis felineus OX=147828 GN=CRM22_008897 PE=4 SV=1) HSP 1 Score: 88.1965 bits (217), Expect = 1.562e-15 Identity = 78/302 (25.83%), Postives = 141/302 (46.69%), Query Frame = 2 Query: 29 MKIRFKYQKKFLIFSMDEIDPTVKQIILGAADKFDLNANNVEISLNANDYYDSENYGSQRASELKIVNGDIIHVRLNGLYDDIKNIVKQEIAYKLEEVLECSNVTYKSPTLLKLL-IPIHLFMSETGFSMRNDGRPFLQFVLDSFHSEASSDEIPKLMRLVYFLFKDSFTVNLTIYYTEPHVCIYGSYPESKSIYFYNFKSKDFILQNQ-ARNAFNKADFVYKNLLQFSNSFKNSIAVPLRIDICLSKFIPTHSFFQVLPYEIIHRILEYLDIKSILSVMSTCQRLNEAGRFCSTIWLRRLL 928 MKIRFK++ KF + + D V ++ +D F + NV+ISLNA D+ S + IVNGDI++V+ L DDI++ ++ E+ ++ + C+ ++ + +L L +P++L +E LQ V D AS +R VY + + T+Y +C+ S E + +D+++ + + F++KNL SN K+ + P+ ++I +P LP+EI+ RI Y+ + ++ +M L + + C+ +W R LL Sbjct: 1 MKIRFKFRNKFHVHEISTKDAHVIDLLRVVSDLFKVALPNVQISLNAKDFMGLAE-SDVPISTVGIVNGDIVYVQSLELLDDIRHSMEHELFTSVDAL--CNQLSLANHNVLSLFALPVYLCANEKK----------LQCV-DELADVASLASTALRLRFVY-VSTPEIHITFTVYTIGNLICMAASCKELQLARQLILSLRDYLVVSALGQQVIPTPSFLFKNLQLLSNRIKDELIEPVLVNIHAELGMPERIMLTNLPFEILTRIFLYVPLLTLGKLMLCNSFLYQQIKSCAPVW-RALL 286
BLAST of F-box domain-containing protein vs. TrEMBL
Match: A0A3Q0KLC2 (F-box domain-containing protein OS=Schistosoma mansoni OX=6183 PE=4 SV=1) HSP 1 Score: 87.8113 bits (216), Expect = 1.688e-15 Identity = 87/313 (27.80%), Postives = 154/313 (49.20%), Query Frame = 2 Query: 29 MKIRFKYQKKFLIFSMDEIDPTVKQIILGAADKFDLNANNVEISLNANDYYDSENYGSQRASELKIVNGDIIHVRLNGLYDDIKNIVKQEIAYKLEEVLECSNVTYKSP--TLLKLLIPIHLFMSETGFSMRNDGRPFLQFVLDSFHSEASSDEIPKLMRLVY-FLFKDSFTVNLTIYYTEPHVCIYGS---YPESKSIYFYNFKSKDFILQNQA--RNAFNKADFVYKNLLQFSNSFKNSIAVPLRIDICLSKFIPTHSFFQVLPYEIIHRILEYLDIKSILSVMSTCQRLNEAGRFCSTIWLRRLLKSTGK 943 MK+R K+ KF +F T+ +I A+ F L NV+ISLNA DYY+ N+ +Q S L IVNGDII++R DDIK ++ E+ + ++ +++T P ++ + IP+++F ++ G +D ++ ++ + SS ++RL + + S V T++ CI S +P K + ++K ++++ A ++ NK + +Y+NL + K+ + P+ + I + LP E+ IL YL + S+ S+M + L R C+TIW +L K K Sbjct: 1 MKLRLKFLNKFHVFETAAASDTLNEIFESASKIFGLKRENVQISLNAKDYYNI-NHSNQSISNLGIVNGDIIYIRSLEKLDDIKQSLEMELTTPIFRLI--NHITNFQPYSSIYLMAIPLYIFATDKGLYNLDD--------INQYYQQRSS-----IIRLTFNYPQVHSIKVIFTLFQNGNMTCIAASVEDHPIRKQLI---LQTKIYLIKQDAICQSTVNKLNLLYRNLRLLAIRIKDKLIEPILLAIHSEFNLSPRLHLCTLPRELFCEILCYLPLTSLGSLMFCNRELYCRIRNCNTIWRIQLAKLNAK 294
BLAST of F-box domain-containing protein vs. TrEMBL
Match: A0A075AEK4 (F-box domain-containing protein OS=Opisthorchis viverrini OX=6198 GN=T265_13928 PE=4 SV=1) HSP 1 Score: 86.2705 bits (212), Expect = 1.103e-14 Identity = 77/320 (24.06%), Postives = 151/320 (47.19%), Query Frame = 2 Query: 29 MKIRFKYQKKFLIFSMDEIDPTVKQII-------LGAADKFDL-NANNVEISLNANDYYDSENYGSQRASELKIVNGDIIHVRLNGLYDDIKNIVKQEIAYKLEEVLECSNVTYKSPTLLKL-LIPIHLFMSETGFSMRNDGRPFLQFVLDSFHSEASSDEIPKLMRLVYFLFKDSFT--------VNLTIYYTEPHVCIYGSYPESKSIYFYNFKSKDFILQNQ-ARNAFNKADFVYKNLLQFSNSFKNSIAVPLRIDICLSKFIPTHSFFQVLPYEIIHRILEYLDIKSILSVMSTCQRLNEAGRFCSTIWLRRLLKS 934 MKIRFK++ +F + + D V ++ + + +L ++ NV+ISLNA D+ S + IVNGDI++V+ L DDI++ ++ E+ ++ + C+ V+ + +L L ++P++L +E + +VL + SS+E+ ++ L + F + T+Y +C+ S E++ +D+++ + + F++KNL SN K+ + P+ ++I +P LP+EI+ RIL YL + ++ +M L + + C+ +W R LL + Sbjct: 1 MKIRFKFRNRFHVHEISAEDAHVIDLLRLLCKCFFSPSGRTNLYHSPNVQISLNAKDFIGLAE-SDVPISTVGIVNGDIVYVQSLELLDDIRHSMEHELFTSVDAL--CNRVSLANHNVLSLFVLPVYLCANEKKLQVL--------YVLCDHRVDQSSNELVDVVNLASTALRLRFVYASTPEIHITFTVYTVGNLICMAASCKEAQLARQLILSLRDYLVVSALGQQVIPTPSFLFKNLQLLSNRIKDELIEPMLVNIHAELGMPERIMLTNLPFEILTRILLYLPLSTLGKLMLCNSFLYQQIKSCAPVW-RALLAT 308
BLAST of F-box domain-containing protein vs. TrEMBL
Match: A0A183QCL5 (Uncharacterized protein OS=Schistosoma rodhaini OX=6188 PE=4 SV=1) HSP 1 Score: 80.4925 bits (197), Expect = 4.252e-13 Identity = 87/313 (27.80%), Postives = 151/313 (48.24%), Query Frame = 2 Query: 29 MKIRFKYQKKFLIFSMDEIDPTVKQIILGAADKFDLNANNVEISLNANDYYDSENYGSQRASELKIVNGDIIHVRLNGLYDDIKNIVKQEIAYKLEEVLECSNVTYKSP--TLLKLLIPIHLFMSETGFSMRNDGRPFLQFVLDSFHSEASSDEIPKLMRLVY-FLFKDSFTVNLTIYYTEPHVCIYGS---YPESKSIYFYNFKSKDFILQNQA--RNAFNKADFVYKNLLQFSNSFKNSIAVPLRIDICLSKFIPTHSFFQVLPYEIIHRILEYLDIKSILSVMSTCQRLNEAGRFCSTIWLRRLLKSTGK 943 MK+R K+ KF +F T+ +I A F L NV+ISLNA DYY+ N+ +Q S L IVNGDII++R DDIK ++ E+ + ++ +++T P ++ + IP+++F ++ G +D L+ ++ + SS ++RL + + S V T++ +CI S +P K + ++K ++++ A ++ NK + +Y+NL + K+ + P+ + I HS IL YL + S+ S+M + L R C+TIW +L K K Sbjct: 1 MKLRLKFLNKFHVFETATASATLNEIFESATKIFGLKRENVQISLNAKDYYNI-NHSNQSISNLGIVNGDIIYIRSLEKLDDIKQSLEIELTTPIFRLI--NHITNFQPYSSIYLMAIPLYIFATDKGLHNLDD--------LNQYYQQRSS-----IIRLTFNYPQVHSIKVIFTLFQNGNMICIAASVQDHPIRKQLI---LQTKIYLIKQDAICQSTVNKLNLLYRNLRLLAIRIKDELIEPILLAI--------HS----------GEILCYLPLTSLGSLMFCNRELYYRIRNCNTIWRIQLAKLNAK 276
BLAST of F-box domain-containing protein vs. Planmine SMEST
Match: SMESG000009405.1 (SMESG000009405.1) HSP 1 Score: 725.702 bits (1872), Expect = 0.000e+0 Identity = 354/355 (99.72%), Postives = 355/355 (100.00%), Query Frame = 2 Query: 29 MKIRFKYQKKFLIFSMDEIDPTVKQIILGAADKFDLNANNVEISLNANDYYDSENYGSQRASELKIVNGDIIHVRLNGLYDDIKNIVKQEIAYKLEEVLECSNVTYKSPTLLKLLIPIHLFMSETGFSMRNDGRPFLQFVLDSFHSEASSDEIPKLMRLVYFLFKDSFTVNLTIYYTEPHVCIYGSYPESKSIYFYNFKSKDFILQNQARNAFNKADFVYKNLLQFSNSFKNSIAVPLRIDICLSKFIPTHSFFQVLPYEIIHRILEYLDIKSILSVMSTCQRLNEAGRFCSTIWLRRLLKSTGKNITEFDSDDITEEREPDNFYKKYLLYQKERKLKRKAANAVSREFDELYYL 1093 MKIRFKYQKKFLIFSMDEIDPTVKQIILGAADKFDLNANNVEISLNANDYYDSENYGSQRASELKIVNGDIIHVRLNGLYDDIKNIVKQEIAYKLEEVLECSNVTYKSPTLLKLLIPIHLFMSETGFSMRNDGRPFLQFVLDSFHSEASSDEIPKLMRL+YFLFKDSFTVNLTIYYTEPHVCIYGSYPESKSIYFYNFKSKDFILQNQARNAFNKADFVYKNLLQFSNSFKNSIAVPLRIDICLSKFIPTHSFFQVLPYEIIHRILEYLDIKSILSVMSTCQRLNEAGRFCSTIWLRRLLKSTGKNITEFDSDDITEEREPDNFYKKYLLYQKERKLKRKAANAVSREFDELYYL Sbjct: 1 MKIRFKYQKKFLIFSMDEIDPTVKQIILGAADKFDLNANNVEISLNANDYYDSENYGSQRASELKIVNGDIIHVRLNGLYDDIKNIVKQEIAYKLEEVLECSNVTYKSPTLLKLLIPIHLFMSETGFSMRNDGRPFLQFVLDSFHSEASSDEIPKLMRLIYFLFKDSFTVNLTIYYTEPHVCIYGSYPESKSIYFYNFKSKDFILQNQARNAFNKADFVYKNLLQFSNSFKNSIAVPLRIDICLSKFIPTHSFFQVLPYEIIHRILEYLDIKSILSVMSTCQRLNEAGRFCSTIWLRRLLKSTGKNITEFDSDDITEEREPDNFYKKYLLYQKERKLKRKAANAVSREFDELYYL 355
BLAST of F-box domain-containing protein vs. Planmine SMEST
Match: SMESG000009405.1 (SMESG000009405.1) HSP 1 Score: 696.041 bits (1795), Expect = 0.000e+0 Identity = 339/340 (99.71%), Postives = 340/340 (100.00%), Query Frame = 2 Query: 74 MDEIDPTVKQIILGAADKFDLNANNVEISLNANDYYDSENYGSQRASELKIVNGDIIHVRLNGLYDDIKNIVKQEIAYKLEEVLECSNVTYKSPTLLKLLIPIHLFMSETGFSMRNDGRPFLQFVLDSFHSEASSDEIPKLMRLVYFLFKDSFTVNLTIYYTEPHVCIYGSYPESKSIYFYNFKSKDFILQNQARNAFNKADFVYKNLLQFSNSFKNSIAVPLRIDICLSKFIPTHSFFQVLPYEIIHRILEYLDIKSILSVMSTCQRLNEAGRFCSTIWLRRLLKSTGKNITEFDSDDITEEREPDNFYKKYLLYQKERKLKRKAANAVSREFDELYYL 1093 MDEIDPTVKQIILGAADKFDLNANNVEISLNANDYYDSENYGSQRASELKIVNGDIIHVRLNGLYDDIKNIVKQEIAYKLEEVLECSNVTYKSPTLLKLLIPIHLFMSETGFSMRNDGRPFLQFVLDSFHSEASSDEIPKLMRL+YFLFKDSFTVNLTIYYTEPHVCIYGSYPESKSIYFYNFKSKDFILQNQARNAFNKADFVYKNLLQFSNSFKNSIAVPLRIDICLSKFIPTHSFFQVLPYEIIHRILEYLDIKSILSVMSTCQRLNEAGRFCSTIWLRRLLKSTGKNITEFDSDDITEEREPDNFYKKYLLYQKERKLKRKAANAVSREFDELYYL Sbjct: 1 MDEIDPTVKQIILGAADKFDLNANNVEISLNANDYYDSENYGSQRASELKIVNGDIIHVRLNGLYDDIKNIVKQEIAYKLEEVLECSNVTYKSPTLLKLLIPIHLFMSETGFSMRNDGRPFLQFVLDSFHSEASSDEIPKLMRLIYFLFKDSFTVNLTIYYTEPHVCIYGSYPESKSIYFYNFKSKDFILQNQARNAFNKADFVYKNLLQFSNSFKNSIAVPLRIDICLSKFIPTHSFFQVLPYEIIHRILEYLDIKSILSVMSTCQRLNEAGRFCSTIWLRRLLKSTGKNITEFDSDDITEEREPDNFYKKYLLYQKERKLKRKAANAVSREFDELYYL 340 The following BLAST results are available for this feature:
BLAST of F-box domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of F-box domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of F-box domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of F-box domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of F-box domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of F-box domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of F-box domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 0
BLAST of F-box domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of F-box domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of F-box domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of F-box domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of F-box domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of F-box domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of F-box domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 2
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30031271 ID=SMED30031271|Name=F-box domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1132bpback to top protein sequence of SMED30031271-orf-1 >SMED30031271-orf-1 ID=SMED30031271-orf-1|Name=SMED30031271-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=356bp MKIRFKYQKKFLIFSMDEIDPTVKQIILGAADKFDLNANNVEISLNANDYback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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