Calcium release-activated calcium channel protein 1

Overview
NameCalcium release-activated calcium channel protein 1
Smed IDSMED30031209
Length (bp)852
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Calcium release-activated calcium channel protein 1 (SMED30031209) t-SNE clustered cells

Violin plots show distribution of expression levels for Calcium release-activated calcium channel protein 1 (SMED30031209) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Calcium release-activated calcium channel protein 1 (SMED30031209) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Calcium release-activated calcium channel protein 1 (SMED30031209) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30031209

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 1

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
gutSMED30031209h1SMcG0003282 dd_Smed_v4_8774_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Human
Match: ORAI2 (ORAI calcium release-activated calcium modulator 2 [Source:HGNC Symbol;Acc:HGNC:21667])

HSP 1 Score: 155.606 bits (392), Expect = 1.289e-45
Identity = 96/237 (40.51%), Postives = 135/237 (56.96%), Query Frame = 2 
Query:  119 NYQDSDYYMLQRR----MTESNNSSDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIE--LEIKNEAPMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPN-ILQSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKF-----------------YKNTIIAVVASCILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDIMENLDDTGDLKTVTVI 757
             ++  DY    RR    +  SN+ S   L WR L LS+AKLKA  +TS LL+GFA+VA++E  LE + + P  L I F  C  +LVAVH+ AL+I+TCILPN+E  S+    N I +SPHE++  YIE+AW  ST +GILLFL    L CW+KF                 +     A+V++ I+ PV LIF++F   FY SL+ HK       + EL+ +   LD  G  +++ V+
Sbjct:   20 GHKGMDYRDWVRRSYLELVTSNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETQYQYPRPLLIAFSACTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLPVDARRQPGPPPGPGSHTGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHNREIEELHKLKVQLD--GHERSLQVL 254
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Human
Match: ORAI2 (ORAI calcium release-activated calcium modulator 2 [Source:HGNC Symbol;Acc:HGNC:21667])

HSP 1 Score: 155.606 bits (392), Expect = 1.289e-45
Identity = 96/237 (40.51%), Postives = 135/237 (56.96%), Query Frame = 2 
Query:  119 NYQDSDYYMLQRR----MTESNNSSDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIE--LEIKNEAPMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPN-ILQSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKF-----------------YKNTIIAVVASCILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDIMENLDDTGDLKTVTVI 757
             ++  DY    RR    +  SN+ S   L WR L LS+AKLKA  +TS LL+GFA+VA++E  LE + + P  L I F  C  +LVAVH+ AL+I+TCILPN+E  S+    N I +SPHE++  YIE+AW  ST +GILLFL    L CW+KF                 +     A+V++ I+ PV LIF++F   FY SL+ HK       + EL+ +   LD  G  +++ V+
Sbjct:   20 GHKGMDYRDWVRRSYLELVTSNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETQYQYPRPLLIAFSACTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLPVDARRQPGPPPGPGSHTGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHNREIEELHKLKVQLD--GHERSLQVL 254
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Human
Match: ORAI2 (ORAI calcium release-activated calcium modulator 2 [Source:HGNC Symbol;Acc:HGNC:21667])

HSP 1 Score: 155.606 bits (392), Expect = 1.289e-45
Identity = 96/237 (40.51%), Postives = 135/237 (56.96%), Query Frame = 2 
Query:  119 NYQDSDYYMLQRR----MTESNNSSDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIE--LEIKNEAPMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPN-ILQSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKF-----------------YKNTIIAVVASCILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDIMENLDDTGDLKTVTVI 757
             ++  DY    RR    +  SN+ S   L WR L LS+AKLKA  +TS LL+GFA+VA++E  LE + + P  L I F  C  +LVAVH+ AL+I+TCILPN+E  S+    N I +SPHE++  YIE+AW  ST +GILLFL    L CW+KF                 +     A+V++ I+ PV LIF++F   FY SL+ HK       + EL+ +   LD  G  +++ V+
Sbjct:   20 GHKGMDYRDWVRRSYLELVTSNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETQYQYPRPLLIAFSACTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLPVDARRQPGPPPGPGSHTGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHNREIEELHKLKVQLD--GHERSLQVL 254
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Human
Match: ORAI2 (ORAI calcium release-activated calcium modulator 2 [Source:HGNC Symbol;Acc:HGNC:21667])

HSP 1 Score: 155.606 bits (392), Expect = 1.289e-45
Identity = 96/237 (40.51%), Postives = 135/237 (56.96%), Query Frame = 2 
Query:  119 NYQDSDYYMLQRR----MTESNNSSDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIE--LEIKNEAPMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPN-ILQSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKF-----------------YKNTIIAVVASCILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDIMENLDDTGDLKTVTVI 757
             ++  DY    RR    +  SN+ S   L WR L LS+AKLKA  +TS LL+GFA+VA++E  LE + + P  L I F  C  +LVAVH+ AL+I+TCILPN+E  S+    N I +SPHE++  YIE+AW  ST +GILLFL    L CW+KF                 +     A+V++ I+ PV LIF++F   FY SL+ HK       + EL+ +   LD  G  +++ V+
Sbjct:   20 GHKGMDYRDWVRRSYLELVTSNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETQYQYPRPLLIAFSACTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLPVDARRQPGPPPGPGSHTGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHNREIEELHKLKVQLD--GHERSLQVL 254
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Human
Match: ORAI2 (ORAI calcium release-activated calcium modulator 2 [Source:HGNC Symbol;Acc:HGNC:21667])

HSP 1 Score: 155.606 bits (392), Expect = 1.289e-45
Identity = 96/237 (40.51%), Postives = 135/237 (56.96%), Query Frame = 2 
Query:  119 NYQDSDYYMLQRR----MTESNNSSDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIE--LEIKNEAPMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPN-ILQSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKF-----------------YKNTIIAVVASCILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDIMENLDDTGDLKTVTVI 757
             ++  DY    RR    +  SN+ S   L WR L LS+AKLKA  +TS LL+GFA+VA++E  LE + + P  L I F  C  +LVAVH+ AL+I+TCILPN+E  S+    N I +SPHE++  YIE+AW  ST +GILLFL    L CW+KF                 +     A+V++ I+ PV LIF++F   FY SL+ HK       + EL+ +   LD  G  +++ V+
Sbjct:   20 GHKGMDYRDWVRRSYLELVTSNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETQYQYPRPLLIAFSACTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLPVDARRQPGPPPGPGSHTGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHNREIEELHKLKVQLD--GHERSLQVL 254
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Celegans
Match: orai-1 (pep chromosome:WBcel235:III:652897:654463:1 gene:WBGene00015648.1 transcript:C09F5.2b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:orai-1)

HSP 1 Score: 103.99 bits (258), Expect = 4.958e-26
Identity = 71/206 (34.47%), Postives = 115/206 (55.83%), Query Frame = 2 
Query:  155 RMTESNNSSDTNLMWRG---------LQLSKAKLKAVGQTSGLLAGFAVVAIIELEIKNEAPMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPNILQSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKFY--KNTIIAVVASCILGPVMLIFIIFAGVFYNSLIGH---KFRHTADMVRELNDIMENLDDT 730
            RM       D +L  RG           LS+A+LKA  +TS LLAGFA+V ++EL+     P  L I   V   +LV+VH++ALM++TCILP +E     +      SPH KL+ YI+++W+ ST IG+LLFLV   +  ++KF          + + +L PV ++F++F+ + + + + H   +F+H  D +++  D+  NL  +
Sbjct:   83 RMPLKKAGDDVDLGHRGELDLSEKYNYDLSRAQLKASSRTSALLAGFAMVCLVELQYDQSTPKPLLIVLGVVTSLLVSVHLLALMMSTCILPYMEATGCTQ-----DSPHIKLKFYIDLSWLFSTCIGLLLFLVEIGVIFYVKFTAVGYPTAGYITTAMLVPVGVVFVVFSYLIHKNRVSHSLGRFKHKVDTMKQFLDVEANLQKS 283
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Celegans
Match: orai-1 (pep chromosome:WBcel235:III:646754:654463:1 gene:WBGene00015648.1 transcript:C09F5.2a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:orai-1)

HSP 1 Score: 103.219 bits (256), Expect = 1.226e-25
Identity = 65/179 (36.31%), Postives = 108/179 (60.34%), Query Frame = 2 
Query:  209 QLSKAKLKAVGQTSGLLAGFAVVAIIELEIKNEAPMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPNILQSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKFYK--NTIIAVVASCILGPVMLIFIIFAGVFYNSLIGH---KFRHTADMVRELNDIMENLDDT 730
             LS+A+LKA  +TS LLAGFA+V ++EL+     P  L I   V   +LV+VH++ALM++TCILP +E     +      SPH KL+ YI+++W+ ST IG+LLFLV   +  ++KF          + + +L PV ++F++F+ + + + + H   +F+H  D +++  D+  NL  +
Sbjct:  114 DLSRAQLKASSRTSALLAGFAMVCLVELQYDQSTPKPLLIVLGVVTSLLVSVHLLALMMSTCILPYMEATGCTQ-----DSPHIKLKFYIDLSWLFSTCIGLLLFLVEIGVIFYVKFTAVGYPTAGYITTAMLVPVGVVFVVFSYLIHKNRVSHSLGRFKHKVDTMKQFLDVEANLQKS 287
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Fly
Match: olf186-F (gene:FBgn0041585 transcript:FBtr0336698)

HSP 1 Score: 158.688 bits (400), Expect = 4.904e-46
Identity = 88/187 (47.06%), Postives = 129/187 (68.98%), Query Frame = 2 
Query:  179 SDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIELEIKNEA--PMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPNIL-QSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKFYKNTIIAVVASC-ILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDIMENLDD 727
            S T L WR LQLS+AKLKA  +TS LL+GFA+VA++E+++ ++   P  + I F +C  +LVAVHM+ALMI+TCILPN+E   +    +++ +SPHE+L  YIE AW  ST +G++LFL+  A+ CW+KFY  +  A  ++C +L PVM+IF+ FA  FY SL+ HK+  T   +REL  + E ++ 
Sbjct:  142 SPTYLSWRKLQLSRAKLKASSKTSALLSGFAMVAMVEVQLDHDTNVPPGMLIAFAICTTLLVAVHMLALMISTCILPNIETVCNLHSISLVHESPHERLHWYIETAWAFSTLLGLILFLLEIAILCWVKFYDLSPPAAWSACVVLIPVMIIFMAFAIHFYRSLVSHKYEVTVSGIRELEMLKEQMEQ 328
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Fly
Match: olf186-F (gene:FBgn0041585 transcript:FBtr0086797)

HSP 1 Score: 158.688 bits (400), Expect = 4.904e-46
Identity = 88/187 (47.06%), Postives = 129/187 (68.98%), Query Frame = 2 
Query:  179 SDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIELEIKNEA--PMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPNIL-QSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKFYKNTIIAVVASC-ILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDIMENLDD 727
            S T L WR LQLS+AKLKA  +TS LL+GFA+VA++E+++ ++   P  + I F +C  +LVAVHM+ALMI+TCILPN+E   +    +++ +SPHE+L  YIE AW  ST +G++LFL+  A+ CW+KFY  +  A  ++C +L PVM+IF+ FA  FY SL+ HK+  T   +REL  + E ++ 
Sbjct:  142 SPTYLSWRKLQLSRAKLKASSKTSALLSGFAMVAMVEVQLDHDTNVPPGMLIAFAICTTLLVAVHMLALMISTCILPNIETVCNLHSISLVHESPHERLHWYIETAWAFSTLLGLILFLLEIAILCWVKFYDLSPPAAWSACVVLIPVMIIFMAFAIHFYRSLVSHKYEVTVSGIRELEMLKEQMEQ 328
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Fly
Match: olf186-F (gene:FBgn0041585 transcript:FBtr0086795)

HSP 1 Score: 158.688 bits (400), Expect = 4.904e-46
Identity = 88/187 (47.06%), Postives = 129/187 (68.98%), Query Frame = 2 
Query:  179 SDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIELEIKNEA--PMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPNIL-QSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKFYKNTIIAVVASC-ILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDIMENLDD 727
            S T L WR LQLS+AKLKA  +TS LL+GFA+VA++E+++ ++   P  + I F +C  +LVAVHM+ALMI+TCILPN+E   +    +++ +SPHE+L  YIE AW  ST +G++LFL+  A+ CW+KFY  +  A  ++C +L PVM+IF+ FA  FY SL+ HK+  T   +REL  + E ++ 
Sbjct:  142 SPTYLSWRKLQLSRAKLKASSKTSALLSGFAMVAMVEVQLDHDTNVPPGMLIAFAICTTLLVAVHMLALMISTCILPNIETVCNLHSISLVHESPHERLHWYIETAWAFSTLLGLILFLLEIAILCWVKFYDLSPPAAWSACVVLIPVMIIFMAFAIHFYRSLVSHKYEVTVSGIRELEMLKEQMEQ 328
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Fly
Match: olf186-F (gene:FBgn0041585 transcript:FBtr0336699)

HSP 1 Score: 160.999 bits (406), Expect = 1.512e-45
Identity = 95/217 (43.78%), Postives = 139/217 (64.06%), Query Frame = 2 
Query:  122 YQDSDYYMLQRR---------MTESNNS--SDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIELEIKNEA--PMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPNIL-QSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKFYKNTIIAVVASC-ILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDIMENLDD 727
            YQ +  Y  Q R         M++S     S T L WR LQLS+AKLKA  +TS LL+GFA+VA++E+++ ++   P  + I F +C  +LVAVHM+ALMI+TCILPN+E   +    +++ +SPHE+L  YIE AW  ST +G++LFL+  A+ CW+KFY  +  A  ++C +L PVM+IF+ FA  FY SL+ HK+  T   +REL  + E ++ 
Sbjct:  268 YQQNQSYRFQPRGHHRTASSSMSQSGEDLHSPTYLSWRKLQLSRAKLKASSKTSALLSGFAMVAMVEVQLDHDTNVPPGMLIAFAICTTLLVAVHMLALMISTCILPNIETVCNLHSISLVHESPHERLHWYIETAWAFSTLLGLILFLLEIAILCWVKFYDLSPPAAWSACVVLIPVMIIFMAFAIHFYRSLVSHKYEVTVSGIRELEMLKEQMEQ 484
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Fly
Match: olf186-F (gene:FBgn0041585 transcript:FBtr0114614)

HSP 1 Score: 160.999 bits (406), Expect = 1.512e-45
Identity = 95/217 (43.78%), Postives = 139/217 (64.06%), Query Frame = 2 
Query:  122 YQDSDYYMLQRR---------MTESNNS--SDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIELEIKNEA--PMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPNIL-QSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKFYKNTIIAVVASC-ILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDIMENLDD 727
            YQ +  Y  Q R         M++S     S T L WR LQLS+AKLKA  +TS LL+GFA+VA++E+++ ++   P  + I F +C  +LVAVHM+ALMI+TCILPN+E   +    +++ +SPHE+L  YIE AW  ST +G++LFL+  A+ CW+KFY  +  A  ++C +L PVM+IF+ FA  FY SL+ HK+  T   +REL  + E ++ 
Sbjct:  268 YQQNQSYRFQPRGHHRTASSSMSQSGEDLHSPTYLSWRKLQLSRAKLKASSKTSALLSGFAMVAMVEVQLDHDTNVPPGMLIAFAICTTLLVAVHMLALMISTCILPNIETVCNLHSISLVHESPHERLHWYIETAWAFSTLLGLILFLLEIAILCWVKFYDLSPPAAWSACVVLIPVMIIFMAFAIHFYRSLVSHKYEVTVSGIRELEMLKEQMEQ 484
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Zebrafish
Match: orai1b (ORAI calcium release-activated calcium modulator 1b [Source:NCBI gene;Acc:402892])

HSP 1 Score: 162.925 bits (411), Expect = 5.039e-49
Identity = 92/219 (42.01%), Postives = 131/219 (59.82%), Query Frame = 2 
Query:  155 RMTESNNSSDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIE--LEIKNEAPMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPN-ILQSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKF-------YKNTII------AVVASCILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDIMENLDDTGDLKTVTVIGS 763
            +M+ S +S    L WR L LS+AKLKA  +TS LL+GFA+VA++E  L+  ++ P  L I F  C  +LVAVH+ ALM++TCILPN+E  S+    N + +SPHE++ ++IE+AW  ST IG LLFL    L CW+KF        KN  +      A+ ++ I+ P  L+FI+FA  FY SL+ HK       + EL D+   LD   ++ T+   GS
Sbjct:    2 KMSRSEHSLQA-LSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDTNHDYPPGLLIAFSACTTVLVAVHLFALMVSTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPIKPKDQKNGTVSAGVAAAITSTSIMVPFGLVFIVFAVHFYRSLVSHKTDRQFQELEELEDLQNELDHREEVSTLQSPGS 219
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Zebrafish
Match: orai1b (ORAI calcium release-activated calcium modulator 1b [Source:NCBI gene;Acc:402892])

HSP 1 Score: 162.925 bits (411), Expect = 5.039e-49
Identity = 92/219 (42.01%), Postives = 131/219 (59.82%), Query Frame = 2 
Query:  155 RMTESNNSSDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIE--LEIKNEAPMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPN-ILQSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKF-------YKNTII------AVVASCILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDIMENLDDTGDLKTVTVIGS 763
            +M+ S +S    L WR L LS+AKLKA  +TS LL+GFA+VA++E  L+  ++ P  L I F  C  +LVAVH+ ALM++TCILPN+E  S+    N + +SPHE++ ++IE+AW  ST IG LLFL    L CW+KF        KN  +      A+ ++ I+ P  L+FI+FA  FY SL+ HK       + EL D+   LD   ++ T+   GS
Sbjct:    2 KMSRSEHSLQA-LSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDTNHDYPPGLLIAFSACTTVLVAVHLFALMVSTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPIKPKDQKNGTVSAGVAAAITSTSIMVPFGLVFIVFAVHFYRSLVSHKTDRQFQELEELEDLQNELDHREEVSTLQSPGS 219
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Zebrafish
Match: orai1a (ORAI calcium release-activated calcium modulator 1a [Source:ZFIN;Acc:ZDB-GENE-110721-1])

HSP 1 Score: 155.606 bits (392), Expect = 4.312e-46
Identity = 93/219 (42.47%), Postives = 124/219 (56.62%), Query Frame = 2 
Query:  170 NNSSDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIE--LEIKNEAPMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPN-ILQSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKFY--------------------KNTIIAVVASCILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDI--MEN-LDDTGDLKTV 748
            N  S   L WR L LS+AKLKA  +TS LL+GFA+VA++E  LE  +  P  L I F  C  +LVAVH+ ALMI+TCILPNLE  S+    N I +SPHE++ ++IE+AW  ST IG LLFL    L CW+KF                     +    A+ ++ I+ P  L+FI+FA  FY SL+ HK     + +  L  I  M+N LD  GD  ++
Sbjct:    4 NEHSLQALSWRKLYLSRAKLKATSRTSALLSGFAMVAMVECQLEEDHNYPPGLLIAFSACTTVLVAVHLFALMISTCILPNLEAVSNVHNLNSIKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPLSQTPVTQKENVTQAPGISEGKAAAIASTTIMVPFALVFIVFAVHFYRSLVSHKTERQHEELEVLAKITQMQNQLDQRGDASSI 222
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Zebrafish
Match: orai2 (ORAI calcium release-activated calcium modulator 2 [Source:ZFIN;Acc:ZDB-GENE-060531-127])

HSP 1 Score: 153.68 bits (387), Expect = 7.769e-45
Identity = 95/232 (40.95%), Postives = 129/232 (55.60%), Query Frame = 2 
Query:  134 DYYMLQRR----MTESNNSSDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIE--LEIKNEAPMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPN-ILQSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKFYK--------NTIIAVVASC--------------------ILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDIMENLD 724
            DY    RR    +  SN+ S   L WR L LS+AKLKA  +TS LL+GFA+VA++E  LE++   P  L I F VC  +LVAVH+ AL+I+TCILPN+E  S+    N + +SPHE++  YIE+AW  ST +GILLFL    L CW+KF          + ++A+  +C                    I+ PV LIF++F   FY SL+ HK       + EL+ I   LD
Sbjct:   27 DYRDWVRRSYLELVTSNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLEMQYNYPRVLLIAFSVCTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSVSESPHERMHHYIELAWGFSTALGILLFLAEVVLLCWIKFLPVDSGAQSASALVALKQNCSTPAVQPGHSGWQAALASTIIMVPVGLIFVVFTIHFYRSLVRHKTERHHQEIEELHKIKVQLD 258
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Zebrafish
Match: orai1a (ORAI calcium release-activated calcium modulator 1a [Source:ZFIN;Acc:ZDB-GENE-110721-1])

HSP 1 Score: 117.087 bits (292), Expect = 9.373e-32
Identity = 71/184 (38.59%), Postives = 101/184 (54.89%), Query Frame = 2 
Query:  275 VAIIELEIKNEA--PMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPN-ILQSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKFY--------------------KNTIIAVVASCILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDI--MEN-LDDTGDLKTV 748
            VA++E +++ +   P  L I F  C  +LVAVH+ ALMI+TCILPNLE  S+    N I +SPHE++ ++IE+AW  ST IG LLFL    L CW+KF                     +    A+ ++ I+ P  L+FI+FA  FY SL+ HK     + +  L  I  M+N LD  GD  ++
Sbjct:    2 VAMVECQLEEDHNYPPGLLIAFSACTTVLVAVHLFALMISTCILPNLEAVSNVHNLNSIKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPLSQTPVTQKENVTQAPGISEGKAAAIASTTIMVPFALVFIVFAVHFYRSLVSHKTERQHEELEVLAKITQMQNQLDQRGDASSI 185
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Xenopus
Match: ORAI1 (ORAI calcium release-activated calcium modulator 2 [Source:NCBI gene;Acc:100380109])

HSP 1 Score: 155.606 bits (392), Expect = 5.304e-46
Identity = 92/214 (42.99%), Postives = 122/214 (57.01%), Query Frame = 2 
Query:  170 NNSSDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIE--LEIKNEAPMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPN-ILQSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKFY----------------KNTIIAVVASCILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDIME------NLDDTGD 736
            N  S   L WR L LS+AKLKA  +TS LL+GFA+VA++E  LE  +  P  L I F  C  +LVAVH+ ALMI+TCILPN+E  S+    N + +SPHE++ ++IE+AW  ST IG LLFL    L CW+KF                      A+ ++ I+ P  L+FI+FA  FY SL+ HK   T    +ELN++ E       LD  GD
Sbjct:    8 NEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLEADHAYPPGLLIAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPVNSPKLSSNDTSTVSSGQAAAIASTAIMVPFGLVFIVFAVHFYRSLVSHK---TDRQFQELNELAELAQLQDQLDHRGD 218
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Xenopus
Match: ORAI1 (ORAI calcium release-activated calcium modulator 2 [Source:NCBI gene;Acc:100380109])

HSP 1 Score: 154.836 bits (390), Expect = 3.124e-45
Identity = 92/214 (42.99%), Postives = 122/214 (57.01%), Query Frame = 2 
Query:  170 NNSSDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIE--LEIKNEAPMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPN-ILQSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKFY----------------KNTIIAVVASCILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDIME------NLDDTGD 736
            N  S   L WR L LS+AKLKA  +TS LL+GFA+VA++E  LE  +  P  L I F  C  +LVAVH+ ALMI+TCILPN+E  S+    N + +SPHE++ ++IE+AW  ST IG LLFL    L CW+KF                      A+ ++ I+ P  L+FI+FA  FY SL+ HK   T    +ELN++ E       LD  GD
Sbjct:   40 NEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLEADHAYPPGLLIAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPVNSPKLSSNDTSTVSSGQAAAIASTAIMVPFGLVFIVFAVHFYRSLVSHK---TDRQFQELNELAELAQLQDQLDHRGD 250
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Xenopus
Match: p2ry12 (purinergic receptor P2Y, G-protein coupled, 12 [Source:Xenbase;Acc:XB-GENE-947453])

HSP 1 Score: 152.14 bits (383), Expect = 2.690e-44
Identity = 94/229 (41.05%), Postives = 130/229 (56.77%), Query Frame = 2 
Query:  134 DYYMLQRR----MTESNNSSDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIE--LEIKNEAPMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPN-ILQSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKF-------YKNTII-------------AVVASCILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDIMENLD--DTG 733
            DY    RR    +  SN+ S   L WR L LS+AKLKA  +TS LL+GFA+VA++E  LE+K   P  L I F  C  +LVAVH+ AL+I+TCILPN+E  S+    N + +SPH+++  YIE+AW  ST +GILLFL    L CW+KF        +N                A++++ I+ PV +IF+IF   FY +L+ HK       + EL+ +   LD  D G
Sbjct:   25 DYRDWVRRSYLELVTSNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLEMKYGYPQLLLIAFSACTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSVNESPHDRMHPYIELAWGFSTALGILLFLAEVVLLCWIKFLPIDSASTRNETTATQKPRGNAGWNSALISTIIMVPVGIIFVIFTIHFYRTLVRHKTERHHQEIEELHKLKVQLDGHDRG 253
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Mouse
Match: Orai2 (ORAI calcium release-activated calcium modulator 2 [Source:MGI Symbol;Acc:MGI:2443195])

HSP 1 Score: 159.073 bits (401), Expect = 4.318e-47
Identity = 97/233 (41.63%), Postives = 135/233 (57.94%), Query Frame = 2 
Query:  119 NYQDSDYYMLQRR----MTESNNSSDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIE--LEIKNEAPMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPN-ILQSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKF-------------YKNTIIAVVASCILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDIMENLDDTGDLKTVTVI 757
             ++  DY    RR    +  SN+ S   L WR L LS+AKLKA  +TS LL+GFA+VA++E  LE K + P  L I F  C  +LVAVH+ AL+I+TCILPN+E  S+    N I +SPHE++  YIE+AW  ST +GILLFL    L CW+KF             +     A+V++ I+ PV LIF++F   FY SL+ HK       + EL+ +   LD  G  +++ V+
Sbjct:   20 GHKGMDYRDWVRRSYLELVTSNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETKYQYPQPLLIAFSACTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLPVDAKDQPGSHSHTGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHNREIEELHKLKVQLD--GHERSLQVV 250
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Mouse
Match: Orai2 (ORAI calcium release-activated calcium modulator 2 [Source:MGI Symbol;Acc:MGI:2443195])

HSP 1 Score: 159.073 bits (401), Expect = 4.861e-47
Identity = 97/233 (41.63%), Postives = 135/233 (57.94%), Query Frame = 2 
Query:  119 NYQDSDYYMLQRR----MTESNNSSDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIE--LEIKNEAPMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPN-ILQSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKF-------------YKNTIIAVVASCILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDIMENLDDTGDLKTVTVI 757
             ++  DY    RR    +  SN+ S   L WR L LS+AKLKA  +TS LL+GFA+VA++E  LE K + P  L I F  C  +LVAVH+ AL+I+TCILPN+E  S+    N I +SPHE++  YIE+AW  ST +GILLFL    L CW+KF             +     A+V++ I+ PV LIF++F   FY SL+ HK       + EL+ +   LD  G  +++ V+
Sbjct:   34 GHKGMDYRDWVRRSYLELVTSNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETKYQYPQPLLIAFSACTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLPVDAKDQPGSHSHTGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHNREIEELHKLKVQLD--GHERSLQVV 264
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Mouse
Match: Orai1 (ORAI calcium release-activated calcium modulator 1 [Source:MGI Symbol;Acc:MGI:1925542])

HSP 1 Score: 147.902 bits (372), Expect = 3.690e-42
Identity = 92/229 (40.17%), Postives = 126/229 (55.02%), Query Frame = 2 
Query:  170 NNSSDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIE--LEIKNEAPMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPN-ILQSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKFYK---------------NTII----------------AVVASCILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDIME------NLDDTGD 736
            N  S   L WR L LS+AKLKA  +TS LL+GFA+VA++E  L+  ++ P  L I F  C  +LVAVH+ ALMI+TCILPN+E  S+    N + +SPHE++ ++IE+AW  ST IG LLFL    L CW+KF                  ++I                A+ ++ I+ P  L+FI+FA  FY SL+ HK   T    +ELN++ E       LD  GD
Sbjct:   69 NEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDTDHDYPPGLLIVFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPLKRQAGQPSPTKPPAESVIVANHSDSSGITPGEAAAIASTAIMVPCGLVFIVFAVHFYRSLVSHK---TDRQFQELNELAEFARLQDQLDHRGD 294
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Mouse
Match: Orai1 (ORAI calcium release-activated calcium modulator 1 [Source:MGI Symbol;Acc:MGI:1925542])

HSP 1 Score: 147.902 bits (372), Expect = 3.690e-42
Identity = 92/229 (40.17%), Postives = 126/229 (55.02%), Query Frame = 2 
Query:  170 NNSSDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIE--LEIKNEAPMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPN-ILQSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKFYK---------------NTII----------------AVVASCILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDIME------NLDDTGD 736
            N  S   L WR L LS+AKLKA  +TS LL+GFA+VA++E  L+  ++ P  L I F  C  +LVAVH+ ALMI+TCILPN+E  S+    N + +SPHE++ ++IE+AW  ST IG LLFL    L CW+KF                  ++I                A+ ++ I+ P  L+FI+FA  FY SL+ HK   T    +ELN++ E       LD  GD
Sbjct:   69 NEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDTDHDYPPGLLIVFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPLKRQAGQPSPTKPPAESVIVANHSDSSGITPGEAAAIASTAIMVPCGLVFIVFAVHFYRSLVSHK---TDRQFQELNELAEFARLQDQLDHRGD 294
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Mouse
Match: Orai3 (ORAI calcium release-activated calcium modulator 3 [Source:MGI Symbol;Acc:MGI:3039586])

HSP 1 Score: 121.709 bits (304), Expect = 2.060e-32
Identity = 61/126 (48.41%), Postives = 88/126 (69.84%), Query Frame = 2 
Query:  191 LMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIELEIKN--EAPMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPN-ILQSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKF 559
            L WR L LS+AKLKA  +TS LL+GFA+VA++E++++N  E P  L + F  C  +LVAVH+ ALM++TC+LP++E  S+    N + QSPH++L +Y+E+AW  ST +G  LFL    L  W+KF
Sbjct:   49 LSWRRLYLSRAKLKASSRTSALLSGFAMVAMVEVQLENDHEYPPGLLVAFSACTTVLVAVHLFALMVSTCLLPHIEAVSNIHNLNSVHQSPHQRLHRYVELAWGFSTALGTFLFLAEVVLVGWVKF 174
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. UniProt/SwissProt
Match: sp|Q6TLE6|CRCM1_DANRE (Calcium release-activated calcium channel protein 1 OS=Danio rerio OX=7955 GN=orai1 PE=2 SV=2)

HSP 1 Score: 162.155 bits (409), Expect = 7.501e-48
Identity = 92/219 (42.01%), Postives = 131/219 (59.82%), Query Frame = 2 
Query:  155 RMTESNNSSDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIE--LEIKNEAPMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPN-ILQSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKF-------YKNTII------AVVASCILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDIMENLDDTGDLKTVTVIGS 763
            +M+ S +S    L WR L LS+AKLKA  +TS LL+GFA+VA++E  L+  ++ P  L I F  C  +LVAVH+ ALM++TCILPN+E  S+    N + +SPHE++ ++IE+AW  ST IG LLFL    L CW+KF        KN  +      A+ ++ I+ P  L+FI+FA  FY SL+ HK       + EL D+   LD   ++ T+   GS
Sbjct:    2 KMSRSEHSLQA-LSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDTNHDYPPGLLIAFSACTTVLVAVHLFALMVSTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAGVVLLCWVKFLPIKPKGQKNGTVSAGVAAAITSTSIMVPFGLVFIVFAVHFYRSLVSHKTDRQFQELEELEDLQNELDHREEVSTLQSPGS 219
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. UniProt/SwissProt
Match: sp|Q8BH10|ORAI2_MOUSE (Protein orai-2 OS=Mus musculus OX=10090 GN=Orai2 PE=2 SV=1)

HSP 1 Score: 159.073 bits (401), Expect = 3.021e-46
Identity = 97/233 (41.63%), Postives = 135/233 (57.94%), Query Frame = 2 
Query:  119 NYQDSDYYMLQRR----MTESNNSSDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIE--LEIKNEAPMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPN-ILQSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKF-------------YKNTIIAVVASCILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDIMENLDDTGDLKTVTVI 757
             ++  DY    RR    +  SN+ S   L WR L LS+AKLKA  +TS LL+GFA+VA++E  LE K + P  L I F  C  +LVAVH+ AL+I+TCILPN+E  S+    N I +SPHE++  YIE+AW  ST +GILLFL    L CW+KF             +     A+V++ I+ PV LIF++F   FY SL+ HK       + EL+ +   LD  G  +++ V+
Sbjct:   20 GHKGMDYRDWVRRSYLELVTSNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETKYQYPQPLLIAFSACTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLPVDAKDQPGSHSHTGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHNREIEELHKLKVQLD--GHERSLQVV 250
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. UniProt/SwissProt
Match: sp|Q5ZL05|CRCM1_CHICK (Calcium release-activated calcium channel protein 1 OS=Gallus gallus OX=9031 GN=ORAI1 PE=2 SV=1)

HSP 1 Score: 157.532 bits (397), Expect = 6.056e-46
Identity = 94/216 (43.52%), Postives = 126/216 (58.33%), Query Frame = 2 
Query:  170 NNSSDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIELEIKNEA--PMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPN-ILQSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKFY---KNTI---------------IAVVASCILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDIME------NLDDTGD 736
            N  S   L WR L LS+AKLKA  +TS LL+GFA+VA++E+++  E   P  L I F  C  +LVAVH+ ALMI+TCILPN+E  S+    N + +SPHE++ ++IE+AW  ST IG LLFL    L CW+KF    KN +                A+ ++ I+ P  LIFI+FA  FY SL+ HK   T    +ELN++ E       LD  GD
Sbjct:    4 NEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDAEHDYPRGLLIAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPLKKNPLDPAENSNSSITSGQAAAIASTSIMVPFGLIFIVFAVHFYRSLVSHK---TDRQFQELNELAEFAWLQDQLDHRGD 216
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. UniProt/SwissProt
Match: sp|Q9U6B8|CRCM1_DROME (Calcium release-activated calcium channel protein 1 OS=Drosophila melanogaster OX=7227 GN=olf186-F PE=1 SV=1)

HSP 1 Score: 158.688 bits (400), Expect = 4.916e-45
Identity = 88/187 (47.06%), Postives = 129/187 (68.98%), Query Frame = 2 
Query:  179 SDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIELEIKNEA--PMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPNIL-QSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKFYKNTIIAVVASC-ILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDIMENLDD 727
            S T L WR LQLS+AKLKA  +TS LL+GFA+VA++E+++ ++   P  + I F +C  +LVAVHM+ALMI+TCILPN+E   +    +++ +SPHE+L  YIE AW  ST +G++LFL+  A+ CW+KFY  +  A  ++C +L PVM+IF+ FA  FY SL+ HK+  T   +REL  + E ++ 
Sbjct:  142 SPTYLSWRKLQLSRAKLKASSKTSALLSGFAMVAMVEVQLDHDTNVPPGMLIAFAICTTLLVAVHMLALMISTCILPNIETVCNLHSISLVHESPHERLHWYIETAWAFSTLLGLILFLLEIAILCWVKFYDLSPPAAWSACVVLIPVMIIFMAFAIHFYRSLVSHKYEVTVSGIRELEMLKEQMEQ 328
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. UniProt/SwissProt
Match: sp|Q96SN7|ORAI2_HUMAN (Protein orai-2 OS=Homo sapiens OX=9606 GN=ORAI2 PE=1 SV=1)

HSP 1 Score: 155.606 bits (392), Expect = 6.189e-45
Identity = 96/237 (40.51%), Postives = 135/237 (56.96%), Query Frame = 2 
Query:  119 NYQDSDYYMLQRR----MTESNNSSDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIE--LEIKNEAPMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPN-ILQSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKF-----------------YKNTIIAVVASCILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDIMENLDDTGDLKTVTVI 757
             ++  DY    RR    +  SN+ S   L WR L LS+AKLKA  +TS LL+GFA+VA++E  LE + + P  L I F  C  +LVAVH+ AL+I+TCILPN+E  S+    N I +SPHE++  YIE+AW  ST +GILLFL    L CW+KF                 +     A+V++ I+ PV LIF++F   FY SL+ HK       + EL+ +   LD  G  +++ V+
Sbjct:   20 GHKGMDYRDWVRRSYLELVTSNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETQYQYPRPLLIAFSACTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLPVDARRQPGPPPGPGSHTGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHNREIEELHKLKVQLD--GHERSLQVL 254
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. TrEMBL
Match: A0A3S5CN70 (Uncharacterized protein OS=Protopolystoma xenopodis OX=117903 GN=PXEA_LOCUS16059 PE=4 SV=1)

HSP 1 Score: 194.897 bits (494), Expect = 7.819e-58
Identity = 99/185 (53.51%), Postives = 135/185 (72.97%), Query Frame = 2 
Query:  191 LMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIELEIK----NEAPMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSS-YRGPNILQSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKFYK-NTIIAVVASCILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDIMENLDD 727
            L WR +QLS+AKLKA  +TS LL+GFA+VAIIEL I+    +  P  L I F   AC+LV VH++ALMI+TCILP+LE +++ Y      +SPHE++R YIE+AWI STG+GILLFLVV  +ACW+KF+  +   A VA+ I+GPV+L+FIIFA +FY SL+ HKF H  +M+ +L+  M  L++
Sbjct:   15 LAWRSIQLSRAKLKASSRTSALLSGFAMVAIIELNIEESDDHPVPEGLIIVFTALACLLVVVHIMALMISTCILPHLESHTNMYDHKAASESPHERMRTYIEMAWIFSTGLGILLFLVVVVMACWVKFWTISKWSAGVATLIIGPVLLVFIIFAALFYRSLVSHKFEHATEMMNKLDLFMSQLEN 199
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. TrEMBL
Match: A0A1D2N1Y8 (Calcium release-activated calcium channel protein 1 OS=Orchesella cincta OX=48709 GN=Ocin01_07778 PE=4 SV=1)

HSP 1 Score: 185.652 bits (470), Expect = 2.302e-54
Identity = 97/215 (45.12%), Postives = 142/215 (66.05%), Query Frame = 2 
Query:  101 MSFYNFNYQDSDYYMLQRRMTESNNSSDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIELEIKNEA--PMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPNILQ-SPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKFYKNTIIAV-VASCILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDIMENLDDTG 733
            M  Y F  +  D Y +     +S +S+ T L WR L LS+AKLKA+ +TS L++GFA+VA++E+++  +   P  L + FV+C  +LVAVHM+ALMI+TCILPN+E  S+    NI++ SPHE++  YIE  W  ST +GI LFL   A+ CW+KFY  +++A   A+ I+ PV+++FI+FA  FY+ L+ HK+  T   +REL  + E LD TG
Sbjct:    8 MGTYEFQDEGDDEYNMNG---DSAHSAATLLSWRKLHLSRAKLKAINKTSALMSGFAMVAMVEMQLNEDTKVPSELLVAFVICTSLLVAVHMLALMISTCILPNVEAISNLHNINIVEESPHERMHWYIEAGWAFSTVLGIFLFLCELAILCWVKFYDYSMMAASSATIIMVPVLILFIVFAIHFYHKLVVHKYELTETGLRELEQLKEQLDSTG 219
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. TrEMBL
Match: A0A226E892 (Calcium release-activated calcium channel protein 1 OS=Folsomia candida OX=158441 GN=Fcan01_12393 PE=4 SV=1)

HSP 1 Score: 183.726 bits (465), Expect = 7.855e-53
Identity = 95/208 (45.67%), Postives = 141/208 (67.79%), Query Frame = 2 
Query:  125 QDSDYYMLQRRMTESNNSSDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIELEIKNEA--PMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPNILQ-SPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKFYKNTIIAV-VASCILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDIMENLDDTGD 736
            + SD Y +    TE   S+ T L WR L LS+AKLKA+ +TS L++GFA+VA++E+++ ++   P  L + FV+C  +LVAVHM+ALMI+TCILPN+E  S+    NI++ SPHE++  YIE  W  ST +GI LFL   A+ CW+KFY  +++A   A+ ++ PV+++FI+FA  FY+ L+ HK+  T   +REL  + +NLD TG 
Sbjct:   73 EASDLYNMS---TEGQYSAATLLSWRKLHLSRAKLKAINKTSALMSGFAMVAMVEMQLNDDTKVPPGLLVAFVICTSLLVAVHMLALMISTCILPNVEAVSNLHNINIVEESPHERMHWYIEAGWAFSTVLGIFLFLCELAILCWVKFYDYSMMAASSATIVMVPVLILFIVFAIHFYHKLVVHKYELTETGLRELEQLKQNLDSTGQ 277
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. TrEMBL
Match: A0A0L8IHU1 (Uncharacterized protein OS=Octopus bimaculoides OX=37653 GN=OCBIM_22014371mg PE=4 SV=1)

HSP 1 Score: 175.252 bits (443), Expect = 1.149e-50
Identity = 89/191 (46.60%), Postives = 133/191 (69.63%), Query Frame = 2 
Query:  167 SNNSSDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIELEIKNEAPMY--LKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRG-PNILQSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKFYKNTIIAVVASCILG-PVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDIMENLDD 727
            +N ++ + L WR L L +AKLKA  +TS LL+GFA+VA++E++ + ++P+   L + F VC  +LVAVH++ALMI+TCILPN+E  S+      + +SPHEK+R YIE+AW  STG+G LLFLV  A+  W+KFYK ++ A +AS  L  PV+++FIIF   FY  L+ HK+ HT   ++EL +++  +D 
Sbjct:    2 TNETTASVLSWRKLYLGRAKLKASSRTSALLSGFAMVAMVEIQFEEKSPLPDCLLVAFSVCTTLLVAVHLIALMISTCILPNIEAVSNMNSFSAVKESPHEKMRWYIEMAWGFSTGLGTLLFLVEIAILSWVKFYKPSVNAAMASTALVIPVLILFIIFGIHFYKRLVAHKYEHTERELQELKELVIKIDQ 192
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. TrEMBL
Match: K7IRN3 (Uncharacterized protein OS=Nasonia vitripennis OX=7425 GN=100123229 PE=4 SV=1)

HSP 1 Score: 175.252 bits (443), Expect = 1.438e-50
Identity = 93/188 (49.47%), Postives = 129/188 (68.62%), Query Frame = 2 
Query:  179 SDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIELEIKN--EAPMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPNIL-QSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKFYK-NTIIAVVASCILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDIMENLDDT 730
            S + + W+ LQLSKAKLKA  +TS LLAGFA+VA++EL++ N  + P  + I F VC  +LVAVHM+ALMI+TCILPN+E  SS      + +SPHE+L  YIEVAW  ST +G+ LFLV  A+ CWL+F++ +T  A   + IL PV++IF+ FA  FY SL+ HK+  T   +REL  + E ++ +
Sbjct:   10 SSSYVAWKKLQLSKAKLKASSKTSALLAGFAMVAMVELQLNNWNDIPEKMIILFTVCTTLLVAVHMLALMISTCILPNIEAVSSMHCITFINESPHERLHWYIEVAWAFSTVLGLFLFLVEIAILCWLRFFEVSTTAAWSGTIILIPVLIIFLAFAVHFYRSLVSHKYEVTVSGIRELELLREQIESS 197
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Cavefish
Match: orai1b (calcium release-activated calcium channel protein 1 [Source:NCBI gene;Acc:103031227])

HSP 1 Score: 166.392 bits (420), Expect = 1.877e-50
Identity = 93/206 (45.15%), Postives = 126/206 (61.17%), Query Frame = 2 
Query:  167 SNNSSDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIE--LEIKNEAPMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPN-ILQSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKF-------YKNTII------AVVASCILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDIMENLDDTGD 736
            S+  S   L WR L LS+AKLKA  +TS LL+GFA+VA++E  L+  ++ P  L I F  C  +LVAVH+ ALMI+TCILPN+E  S+    N +L+SPHE++++YIE+AW  ST IG LLFL    L CW+KF        KN  +      A+ ++ I+ P  L+FI+FA  FY SL+ HK       + EL D+   LD  GD
Sbjct:    2 SSARSLQALTWRRLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDTSHDYPPGLLIAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNAVLESPHERMQRYIELAWAFSTVIGTLLFLAEVVLLCWVKFLPVRPRNQKNGTMPAGVAAAITSTSIMVPFGLVFIVFAVHFYRSLVSHKTDRQFQELEELEDLQNELDQGGD 207
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Cavefish
Match: orai2 (ORAI calcium release-activated calcium modulator 2 [Source:ZFIN;Acc:ZDB-GENE-060531-127])

HSP 1 Score: 162.54 bits (410), Expect = 1.562e-48
Identity = 96/216 (44.44%), Postives = 128/216 (59.26%), Query Frame = 2 
Query:  134 DYYMLQRR----MTESNNSSDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIE--LEIKNEAPMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPN-ILQSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKF------------YKNTIIAVVASCILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDIMENLD 724
            DY    RR    +  SN+ S   L WR L LS+AKLKA  +TS LL+GFA+VA++E  LE++   P  L I F VC  +LVAVH+ AL+I+TCILPN+E  S+    N + +SPHE++ KYIE+AW  ST +GILLFL    L CW+KF            +     A+ ++ I+ PV LIF+IF   FY SL+ HK       + EL+ I   LD
Sbjct:   27 DYRDWVRRSYLELVTSNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLEMQYSYPRVLLIAFSVCTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSVSESPHERMHKYIELAWGFSTALGILLFLAEVVLLCWIKFLPVDSGAASQPGHSGWQAALASTIIMVPVGLIFVIFTIHFYRSLVRHKTERHHQEIEELHKIKVQLD 242
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Cavefish
Match: orai1a (ORAI calcium release-activated calcium modulator 1 [Source:NCBI gene;Acc:103036052])

HSP 1 Score: 149.828 bits (377), Expect = 7.015e-44
Identity = 86/200 (43.00%), Postives = 119/200 (59.50%), Query Frame = 2 
Query:  170 NNSSDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIELEIKNEA--PMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPN-ILQSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKFY-----------KNTII------AVVASCILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDI 709
            N  S   L WR L LS+AKLKA  +TS LL+GFA+VA++E++++ +   P  L I F  C  +LVAVH+ ALMI+TCILPNLE  S+    N + +SPHE++  +IE+AW  ST IG  LFL    L CW+KF             N+ I      A  ++CI+ P  L+FI+FA  FY SL+ HK       + EL+++
Sbjct:    4 NEHSLQALSWRKLYLSRAKLKATSRTSALLSGFAMVAMVEVQLERDYNYPPGLLIAFSACTTVLVAVHLFALMISTCILPNLEAVSNVHNLNSVKESPHERMHHHIELAWAFSTVIGTFLFLAEVLLLCWVKFLPLKKDREPRNNDNSTISAGEAAAYASTCIIVPCGLVFIVFAVHFYRSLVSHKTDRQFQELEELSNL 203
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002932.1 (pep scaffold:Pmarinus_7.0:GL481821:1:1945:-1 gene:ENSPMAG00000002683.1 transcript:ENSPMAT00000002932.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 61.6178 bits (148), Expect = 5.925e-13
Identity = 35/66 (53.03%), Postives = 46/66 (69.70%), Query Frame = 2 
Query:  191 LMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIE--LEIKNEAPMYLKIPFVVCACILVAVHMVALM 382
            L WR L LS+AKLKA  +TS LL+GFA+VA++E  L+ +   P  L + F VC  +LVAVH+ ALM
Sbjct:   11 LSWRRLYLSRAKLKASSRTSALLSGFAMVAMVEAQLDARYTYPPALLVSFSVCTTVLVAVHLFALM 76
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Nematostella
Match: EDO41133 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S528])

HSP 1 Score: 143.665 bits (361), Expect = 1.938e-42
Identity = 78/189 (41.27%), Postives = 118/189 (62.43%), Query Frame = 2 
Query:  191 LMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIELEIKNEAPMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYR---GPNILQSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKFYK-NTIIAVVASCILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDIMENLDDTGDLKT 745
            L WR L L++ KLKA  +TS L++GFA++A++E++++   P  L I F V   IL++VH+ ALMI+ CILPN+E  ++     G  +  SPHEK+  Y+E+AWI STG+G LLFL    +  W+KFYK +   A+ +S +L PV ++F++FA  FY SL  H++      + EL  I   L+ +    T
Sbjct:    1 LSWRRLLLTRGKLKASSRTSALMSGFAMIAMVEIQLEEGIPGGLLIAFSVMTTILISVHVFALMISVCILPNIESVANTHQSSGLMVHDSPHEKMHLYVELAWIFSTGLGTLLFLGEIGILSWVKFYKYSIAAAIASSAVLLPVCVLFVVFAVHFYRSLAQHRYERFYQGIEELQQIASQLESSSAPNT 189
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Medaka
Match: orai1a (calcium release-activated calcium channel protein 1 [Source:NCBI gene;Acc:101161896])

HSP 1 Score: 155.606 bits (392), Expect = 2.723e-46
Identity = 92/210 (43.81%), Postives = 127/210 (60.48%), Query Frame = 2 
Query:  167 SNNSSDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIELEIKNEA--PMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPN-ILQSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKF--YKN-------TII-----AVVASCILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDIM---ENLDDTGD 736
            S+  S   L WR L LS+AKLKA  +TS LL+GFA+VA++E++++ +   P  L I F  C  +LVAVH+ ALMI+TCILPNLE  S+    N + +SPHE++  +IE+AW  ST IG  LFL    L CW+KF   KN       TI      A+ ++CI+ P  L+FI+FA  FY +L+ HK   T   +REL  ++     LD T +
Sbjct:    2 SSEHSLQALSWRKLYLSRAKLKATSRTSALLSGFAMVAMVEVQLEADHVYPPGLLIAFSACTTVLVAVHLFALMISTCILPNLEAVSNVHNLNSVNESPHERMHHHIELAWAFSTVIGTFLFLTEVTLLCWVKFLPLKNNKEVNNGTITSGEAAAIASTCIMVPFGLVFIVFAVHFYRTLVSHK---TDRQIRELEQVINLHNQLDHTAE 208
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Medaka
Match: orai1b (calcium release-activated calcium channel protein 1 [Source:NCBI gene;Acc:101168800])

HSP 1 Score: 155.221 bits (391), Expect = 3.916e-46
Identity = 88/208 (42.31%), Postives = 126/208 (60.58%), Query Frame = 2 
Query:  170 NNSSDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIELEIKNEAPM--YLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPN-ILQSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKFY--------KNTI-----IAVVASCILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDIME---NLDDTGD 736
            N  S   L WR L LS+AKLKA  +TS LL+GFA+VA++E+++ N  P    L I F  C  +LVAVH+ ALM++TCILPN+E  S+    N + +SPH+++ ++IE+AW  ST IG LLFL    L CW+KF          NT+      A+ ++ I+ P  LIFI+FA  FY SL+ HK       + EL+++ +    LD+ G+
Sbjct:    6 NEHSLQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDNSYPYPPALLIAFSACTTVLVAVHLFALMVSTCILPNIEAVSNVHNLNSVKESPHDRMHRHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPIKPNKSSNNTMSSGVAAAITSTSIMVPFGLIFIVFAVHFYRSLVSHKTDRQFQELEELSNLTKLQNELDNRGE 213
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Medaka
Match: orai2 (protein orai-2 [Source:NCBI gene;Acc:101164245])

HSP 1 Score: 141.354 bits (355), Expect = 2.883e-40
Identity = 94/229 (41.05%), Postives = 131/229 (57.21%), Query Frame = 2 
Query:  134 DYYMLQRR----MTESNNSSDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIELEIKNE--APMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPN-ILQSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKF-----------------YKNTI--------IAVVASCILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDIMENLD 724
            DY    RR    +  SN+ S   L WR L LS+AKLKA  +TS LL+GFA+VA++E+E+K +   P  L I F VC  +LVAVH+ AL+I+TCILPN+E  S+    N + +SPHE++  YIE+AW  ST +GILLFL    L CW+KF                   +T+         A+ ++ I+ PV +IF++FA  FY +L+ HK       + EL+ I   LD
Sbjct:   28 DYRDWVRRSYLELVSSNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVELKEQYNYPRELIIAFSVCTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSVSESPHERMHHYIELAWGFSTALGILLFLAEVVLLCWVKFLPVDSGKERKKPSPGATTPSTVGPTDSGWHAALASTIIMVPVAVIFVVFAVHFYRTLVRHKTDRHHQEIEELHKIKVQLD 256
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Medaka
Match: orai2 (protein orai-2 [Source:NCBI gene;Acc:101164245])

HSP 1 Score: 139.813 bits (351), Expect = 1.539e-39
Identity = 90/218 (41.28%), Postives = 127/218 (58.26%), Query Frame = 2 
Query:  155 RMTESNNSSDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIELEIKNE--APMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPN-ILQSPHEKLRKYIEVAWICSTGIGILLFLVVAALACWLKF-----------------YKNTI--------IAVVASCILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVRELNDIMENLD 724
             +  SN+ S   L WR L LS+AKLKA  +TS LL+GFA+VA++E+E+K +   P  L I F VC  +LVAVH+ AL+I+TCILPN+E  S+    N + +SPHE++  YIE+AW  ST +GILLFL    L CW+KF                   +T+         A+ ++ I+ PV +IF++FA  FY +L+ HK       + EL+ I   LD
Sbjct:   54 ELVSSNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVELKEQYNYPRELIIAFSVCTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSVSESPHERMHHYIELAWGFSTALGILLFLAEVVLLCWVKFLPVDSGKERKKPSPGATTPSTVGPTDSGWHAALASTIIMVPVAVIFVVFAVHFYRTLVRHKTDRHHQEIEELHKIKVQLD 271
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. Planmine SMEST
Match: SMESG000032781.1 (SMESG000032781.1)

HSP 1 Score: 248.44 bits (633), Expect = 5.840e-84
Identity = 118/122 (96.72%), Postives = 119/122 (97.54%), Query Frame = 2 
Query:  119 NYQDSDYYMLQRRMTESNNSSDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIELEIKNEAPMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPNILQSPHEKLRKYIEV 484
            NYQDSDYYMLQRRMTESNNSSDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIELEIKNEAPMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPNILQSPHEKLRK   +
Sbjct:    5 NYQDSDYYMLQRRMTESNNSSDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIELEIKNEAPMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPNILQSPHEKLRKLFHI 126
[Close]
BLAST of Calcium release-activated calcium channel protein 1 vs. Planmine SMEST
Match: SMESG000032795.1 (SMESG000032795.1)

HSP 1 Score: 247.669 bits (631), Expect = 7.455e-84
Identity = 118/118 (100.00%), Postives = 118/118 (100.00%), Query Frame = 2 
Query:  119 NYQDSDYYMLQRRMTESNNSSDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIELEIKNEAPMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPNILQSPHEKLRK 472
            NYQDSDYYMLQRRMTESNNSSDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIELEIKNEAPMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPNILQSPHEKLRK
Sbjct:    5 NYQDSDYYMLQRRMTESNNSSDTNLMWRGLQLSKAKLKAVGQTSGLLAGFAVVAIIELEIKNEAPMYLKIPFVVCACILVAVHMVALMIATCILPNLEMYSSYRGPNILQSPHEKLRK 122
The following BLAST results are available for this feature:
BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ORAI21.289e-4540.51ORAI calcium release-activated calcium modulator 2... [more]
ORAI21.289e-4540.51ORAI calcium release-activated calcium modulator 2... [more]
ORAI21.289e-4540.51ORAI calcium release-activated calcium modulator 2... [more]
ORAI21.289e-4540.51ORAI calcium release-activated calcium modulator 2... [more]
ORAI21.289e-4540.51ORAI calcium release-activated calcium modulator 2... [more]
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BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2
Match NameE-valueIdentityDescription
orai-14.958e-2634.47pep chromosome:WBcel235:III:652897:654463:1 gene:W... [more]
orai-11.226e-2536.31pep chromosome:WBcel235:III:646754:654463:1 gene:W... [more]
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BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
olf186-F4.904e-4647.06gene:FBgn0041585 transcript:FBtr0336698[more]
olf186-F4.904e-4647.06gene:FBgn0041585 transcript:FBtr0086797[more]
olf186-F4.904e-4647.06gene:FBgn0041585 transcript:FBtr0086795[more]
olf186-F1.512e-4543.78gene:FBgn0041585 transcript:FBtr0336699[more]
olf186-F1.512e-4543.78gene:FBgn0041585 transcript:FBtr0114614[more]
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BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
orai1b5.039e-4942.01ORAI calcium release-activated calcium modulator 1... [more]
orai1b5.039e-4942.01ORAI calcium release-activated calcium modulator 1... [more]
orai1a4.312e-4642.47ORAI calcium release-activated calcium modulator 1... [more]
orai27.769e-4540.95ORAI calcium release-activated calcium modulator 2... [more]
orai1a9.373e-3238.59ORAI calcium release-activated calcium modulator 1... [more]
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BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 3
Match NameE-valueIdentityDescription
ORAI15.304e-4642.99ORAI calcium release-activated calcium modulator 2... [more]
ORAI13.124e-4542.99ORAI calcium release-activated calcium modulator 2... [more]
p2ry122.690e-4441.05purinergic receptor P2Y, G-protein coupled, 12 [So... [more]
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BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Orai24.318e-4741.63ORAI calcium release-activated calcium modulator 2... [more]
Orai24.861e-4741.63ORAI calcium release-activated calcium modulator 2... [more]
Orai13.690e-4240.17ORAI calcium release-activated calcium modulator 1... [more]
Orai13.690e-4240.17ORAI calcium release-activated calcium modulator 1... [more]
Orai32.060e-3248.41ORAI calcium release-activated calcium modulator 3... [more]
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BLAST of Calcium release-activated calcium channel protein 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q6TLE6|CRCM1_DANRE7.501e-4842.01Calcium release-activated calcium channel protein ... [more]
sp|Q8BH10|ORAI2_MOUSE3.021e-4641.63Protein orai-2 OS=Mus musculus OX=10090 GN=Orai2 P... [more]
sp|Q5ZL05|CRCM1_CHICK6.056e-4643.52Calcium release-activated calcium channel protein ... [more]
sp|Q9U6B8|CRCM1_DROME4.916e-4547.06Calcium release-activated calcium channel protein ... [more]
sp|Q96SN7|ORAI2_HUMAN6.189e-4540.51Protein orai-2 OS=Homo sapiens OX=9606 GN=ORAI2 PE... [more]
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BLAST of Calcium release-activated calcium channel protein 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A3S5CN707.819e-5853.51Uncharacterized protein OS=Protopolystoma xenopodi... [more]
A0A1D2N1Y82.302e-5445.12Calcium release-activated calcium channel protein ... [more]
A0A226E8927.855e-5345.67Calcium release-activated calcium channel protein ... [more]
A0A0L8IHU11.149e-5046.60Uncharacterized protein OS=Octopus bimaculoides OX... [more]
K7IRN31.438e-5049.47Uncharacterized protein OS=Nasonia vitripennis OX=... [more]
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BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 3
Match NameE-valueIdentityDescription
orai1b1.877e-5045.15calcium release-activated calcium channel protein ... [more]
orai21.562e-4844.44ORAI calcium release-activated calcium modulator 2... [more]
orai1a7.015e-4443.00ORAI calcium release-activated calcium modulator 1... [more]
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BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ENSPMAT00000002932.15.925e-1353.03pep scaffold:Pmarinus_7.0:GL481821:1:1945:-1 gene:... [more]
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BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO411331.938e-4241.27Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Calcium release-activated calcium channel protein 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 4
Match NameE-valueIdentityDescription
orai1a2.723e-4643.81calcium release-activated calcium channel protein ... [more]
orai1b3.916e-4642.31calcium release-activated calcium channel protein ... [more]
orai22.883e-4041.05protein orai-2 [Source:NCBI gene;Acc:101164245][more]
orai21.539e-3941.28protein orai-2 [Source:NCBI gene;Acc:101164245][more]
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BLAST of Calcium release-activated calcium channel protein 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000032781.15.840e-8496.72SMESG000032781.1[more]
SMESG000032795.17.455e-84100.00SMESG000032795.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30031209 ID=SMED30031209|Name=Calcium release-activated calcium channel protein 1|organism=Schmidtea mediterranea sexual|type=transcript|length=852bp
CTAATATTTGGATTGCTGCATCAAAATACAATGACAATTAATTCAAATTA
GTTCTATATGGATCTAGCTTTACACCTCAAACCATTTAAATGCTTTCAAA
ATGAGTTTTTATAATTTTAACTATCAAGACTCCGATTATTATATGCTTCA
AAGACGCATGACAGAATCTAACAATTCTTCAGATACAAATTTGATGTGGA
GAGGATTACAACTTAGTAAGGCAAAATTGAAGGCTGTCGGACAAACTTCT
GGCCTACTCGCTGGTTTTGCCGTAGTTGCAATAATTGAATTAGAAATTAA
AAATGAAGCACCAATGTATCTAAAAATTCCATTTGTCGTATGTGCTTGTA
TTTTGGTTGCAGTTCATATGGTGGCTTTAATGATTGCGACATGTATTCTA
CCAAATTTGGAAATGTATTCTTCTTACAGAGGACCGAATATTTTACAATC
TCCTCATGAAAAATTACGAAAATATATTGAAGTTGCCTGGATATGTAGTA
CTGGGATAGGAATTTTATTGTTTCTAGTTGTGGCAGCTTTAGCTTGTTGG
TTAAAATTTTATAAAAATACAATTATTGCAGTAGTCGCAAGCTGTATTTT
AGGTCCAGTGATGCTTATTTTTATTATCTTTGCTGGAGTTTTTTATAATT
CTTTAATTGGACATAAATTTAGACACACTGCAGACATGGTTAGAGAATTG
AATGATATAATGGAAAATTTAGACGACACTGGTGACCTCAAAACTGTTAC
TGTAATTGGTTCGTAAATTTATTTCAATGTGGTCATTTAATATTGTATTT
TATTTTGCTATATTTATTATTTTCTATAATATATCTAGAATTTCATATAA
AA
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protein sequence of SMED30031209-orf-1

>SMED30031209-orf-1 ID=SMED30031209-orf-1|Name=SMED30031209-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=222bp
MSFYNFNYQDSDYYMLQRRMTESNNSSDTNLMWRGLQLSKAKLKAVGQTS
GLLAGFAVVAIIELEIKNEAPMYLKIPFVVCACILVAVHMVALMIATCIL
PNLEMYSSYRGPNILQSPHEKLRKYIEVAWICSTGIGILLFLVVAALACW
LKFYKNTIIAVVASCILGPVMLIFIIFAGVFYNSLIGHKFRHTADMVREL
NDIMENLDDTGDLKTVTVIGS*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
Vocabulary: INTERPRO
TermDefinition
IPR038350Orai_sf
IPR012446CRAC_channel
Vocabulary: cellular component
TermDefinition
GO:0016020membrane
GO:0016021integral component of membrane
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR012446Calcium release-activated calcium channel proteinPFAMPF07856Orai-1coord: 30..189
e-value: 1.2E-50
score: 171.6
IPR012446Calcium release-activated calcium channel proteinPANTHERPTHR31501FAMILY NOT NAMEDcoord: 17..210
IPR038350Orai superfamilyGENE3DG3DSA:1.20.140.140coord: 19..218
e-value: 2.3E-68
score: 231.6
NoneNo IPR availablePANTHERPTHR31501:SF7CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL PROTEIN 1coord: 17..210
NoneNo IPR availableTMHMMTMhelixcoord: 77..99
NoneNo IPR availableTMHMMTMhelixcoord: 158..180
NoneNo IPR availableTMHMMTMhelixcoord: 45..64
NoneNo IPR availableTMHMMTMhelixcoord: 129..151