SMB domain-containing protein

Overview
NameSMB domain-containing protein
Smed IDSMED30031183
Length (bp)1105
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of SMB domain-containing protein (SMED30031183) t-SNE clustered cells

Violin plots show distribution of expression levels for SMB domain-containing protein (SMED30031183) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of SMB domain-containing protein (SMED30031183) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for SMB domain-containing protein (SMED30031183) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30031183

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 9

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
head regionSMED30031183SMESG000079236.1 SmedASXL_011933SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
nervous systemSMED30031183SMESG000079236.1 dd_Smed_v4_11622_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30031183SMESG000079236.1 dd_Smed_v4_11622_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30031183SMESG000079236.1 dd_Smed_v4_11622_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30031183SMESG000079236.1 SMESG000018777.1 Contig46614newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30031183SMESG000079236.1 SMESG000018777.1 Contig46614uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
head regionSMED30031183SMESG000079236.1 dd_Smed_v6_11622_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
head regionSMED30031183SMESG000079236.1 OX_Smed_1.0.18426ox_Smed_v2PMID:24238224
Kao et al., 2013		whole organism asexual adult RNA-sequencing evidence
nervous systemSMED30031183SMESG000079236.1 dd_Smed_v4_11622_0_1dd_Smed_v4PMID:30962434
Cote et al., 2019		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of SMB domain-containing protein vs. Ensembl Human
Match: SBSPON (somatomedin B and thrombospondin type 1 domain containing [Source:HGNC Symbol;Acc:HGNC:30362])

HSP 1 Score: 53.1434 bits (126), Expect = 2.595e-7
Identity = 32/107 (29.91%), Postives = 44/107 (41.12%), Query Frame = 1 
Query:  208 CCQGKNHTCHG----FDKIGSKWAGRQIKCFCDEHCVKSKDCCSDYKRLCSTKAINCILSNWGQWSPCSVDCGAGVQTRFRKVIIPQQHNGRTCDHTEQARFCHNNS 516
            CC G++  C       D++          CFCD+ C  + DCC DY R C  +   C +  W  WS C+  C    + R R V    Q+ G  C   E+   C   S
Sbjct:   28 CCPGRDPACFARGWRLDRVYGT-------CFCDQACRFTGDCCFDYDRACPARP--CFVGEWSPWSGCADQCKPTTRVRRRSVQQEPQNGGAPCPPLEERAGCLEYS 125
[Close]
BLAST of SMB domain-containing protein vs. Ensembl Human
Match: ADGRB2 (adhesion G protein-coupled receptor B2 [Source:HGNC Symbol;Acc:HGNC:944])

HSP 1 Score: 50.8322 bits (120), Expect = 3.576e-6
Identity = 28/89 (31.46%), Postives = 42/89 (47.19%), Query Frame = 1 
Query:  304 VKSKDCCSD-YKRLCS-------------TKAINCILSNWGQWSPCSVDCGAGVQTRFRKVIIPQQHNGRTCDHTE-QARFCHNNSCSI 525
            V+++ C S  Y  LCS             T  ++ +   WG WS CS  CG G ++R R   +P QH G+ C+  E Q + C   +C +
Sbjct:  319 VRTRSCVSSPYGTLCSGPLRETRPCNNSATCPVHGVWEEWGSWSLCSRSCGRGSRSRMR-TCVPPQHGGKACEGPELQTKLCSMAACPV 406
[Close]
BLAST of SMB domain-containing protein vs. Ensembl Human
Match: ADGRB2 (adhesion G protein-coupled receptor B2 [Source:HGNC Symbol;Acc:HGNC:944])

HSP 1 Score: 50.8322 bits (120), Expect = 3.702e-6
Identity = 28/89 (31.46%), Postives = 42/89 (47.19%), Query Frame = 1 
Query:  304 VKSKDCCSD-YKRLCS-------------TKAINCILSNWGQWSPCSVDCGAGVQTRFRKVIIPQQHNGRTCDHTE-QARFCHNNSCSI 525
            V+++ C S  Y  LCS             T  ++ +   WG WS CS  CG G ++R R   +P QH G+ C+  E Q + C   +C +
Sbjct:  331 VRTRSCVSSPYGTLCSGPLRETRPCNNSATCPVHGVWEEWGSWSLCSRSCGRGSRSRMR-TCVPPQHGGKACEGPELQTKLCSMAACPV 418
[Close]
BLAST of SMB domain-containing protein vs. Ensembl Human
Match: ADGRB2 (adhesion G protein-coupled receptor B2 [Source:HGNC Symbol;Acc:HGNC:944])

HSP 1 Score: 50.8322 bits (120), Expect = 3.946e-6
Identity = 28/89 (31.46%), Postives = 42/89 (47.19%), Query Frame = 1 
Query:  304 VKSKDCCSD-YKRLCS-------------TKAINCILSNWGQWSPCSVDCGAGVQTRFRKVIIPQQHNGRTCDHTE-QARFCHNNSCSI 525
            V+++ C S  Y  LCS             T  ++ +   WG WS CS  CG G ++R R   +P QH G+ C+  E Q + C   +C +
Sbjct:  331 VRTRSCVSSPYGTLCSGPLRETRPCNNSATCPVHGVWEEWGSWSLCSRSCGRGSRSRMR-TCVPPQHGGKACEGPELQTKLCSMAACPV 418
[Close]
BLAST of SMB domain-containing protein vs. Ensembl Human
Match: ADGRB2 (adhesion G protein-coupled receptor B2 [Source:HGNC Symbol;Acc:HGNC:944])

HSP 1 Score: 50.8322 bits (120), Expect = 3.946e-6
Identity = 28/89 (31.46%), Postives = 42/89 (47.19%), Query Frame = 1 
Query:  304 VKSKDCCSD-YKRLCS-------------TKAINCILSNWGQWSPCSVDCGAGVQTRFRKVIIPQQHNGRTCDHTE-QARFCHNNSCSI 525
            V+++ C S  Y  LCS             T  ++ +   WG WS CS  CG G ++R R   +P QH G+ C+  E Q + C   +C +
Sbjct:  331 VRTRSCVSSPYGTLCSGPLRETRPCNNSATCPVHGVWEEWGSWSLCSRSCGRGSRSRMR-TCVPPQHGGKACEGPELQTKLCSMAACPV 418
[Close]
BLAST of SMB domain-containing protein vs. Ensembl Celegans
Match: R17.3 (pep chromosome:WBcel235:III:10837445:10839451:1 gene:WBGene00011269.1 transcript:R17.3c.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:R17.3)

HSP 1 Score: 70.4774 bits (171), Expect = 1.025e-13
Identity = 32/78 (41.03%), Postives = 46/78 (58.97%), Query Frame = 1 
Query:  280 KCFCDEHCVKSKDCCSDYKRLCSTKAINCILSNWGQWSPCSVD---CGAGVQTRFRKVIIPQQHNGRTCDHTEQARFC 504
            +C+CDEHCV   DCCSDY  +C  +  +C+L++W  W+ C+ D   CG G Q R R VI   +  G  C+  ++ R C
Sbjct:   32 ECYCDEHCVTLGDCCSDYTFVCPPR--DCVLTDWDSWTQCTADNGTCGIGTQKRLRHVIQHAERGGAACEPLKEMRTC 107
[Close]
BLAST of SMB domain-containing protein vs. Ensembl Celegans
Match: R17.3 (pep chromosome:WBcel235:III:10832936:10839451:1 gene:WBGene00011269.1 transcript:R17.3a.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:R17.3)

HSP 1 Score: 71.2478 bits (173), Expect = 2.523e-13
Identity = 32/78 (41.03%), Postives = 46/78 (58.97%), Query Frame = 1 
Query:  280 KCFCDEHCVKSKDCCSDYKRLCSTKAINCILSNWGQWSPCSVD---CGAGVQTRFRKVIIPQQHNGRTCDHTEQARFC 504
            +C+CDEHCV   DCCSDY  +C  +  +C+L++W  W+ C+ D   CG G Q R R VI   +  G  C+  ++ R C
Sbjct:  218 ECYCDEHCVTLGDCCSDYTFVCPPR--DCVLTDWDSWTQCTADNGTCGIGTQKRLRHVIQHAERGGAACEPLKEMRTC 293
[Close]
BLAST of SMB domain-containing protein vs. Ensembl Celegans
Match: R17.3 (pep chromosome:WBcel235:III:10835014:10839451:1 gene:WBGene00011269.1 transcript:R17.3a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:R17.3)

HSP 1 Score: 71.2478 bits (173), Expect = 2.523e-13
Identity = 32/78 (41.03%), Postives = 46/78 (58.97%), Query Frame = 1 
Query:  280 KCFCDEHCVKSKDCCSDYKRLCSTKAINCILSNWGQWSPCSVD---CGAGVQTRFRKVIIPQQHNGRTCDHTEQARFC 504
            +C+CDEHCV   DCCSDY  +C  +  +C+L++W  W+ C+ D   CG G Q R R VI   +  G  C+  ++ R C
Sbjct:  218 ECYCDEHCVTLGDCCSDYTFVCPPR--DCVLTDWDSWTQCTADNGTCGIGTQKRLRHVIQHAERGGAACEPLKEMRTC 293
[Close]
BLAST of SMB domain-containing protein vs. Ensembl Celegans
Match: R17.3 (pep chromosome:WBcel235:III:10832936:10839451:1 gene:WBGene00011269.1 transcript:R17.3b.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:R17.3)

HSP 1 Score: 70.8626 bits (172), Expect = 2.606e-13
Identity = 32/78 (41.03%), Postives = 46/78 (58.97%), Query Frame = 1 
Query:  280 KCFCDEHCVKSKDCCSDYKRLCSTKAINCILSNWGQWSPCSVD---CGAGVQTRFRKVIIPQQHNGRTCDHTEQARFC 504
            +C+CDEHCV   DCCSDY  +C  +  +C+L++W  W+ C+ D   CG G Q R R VI   +  G  C+  ++ R C
Sbjct:  207 ECYCDEHCVTLGDCCSDYTFVCPPR--DCVLTDWDSWTQCTADNGTCGIGTQKRLRHVIQHAERGGAACEPLKEMRTC 282
[Close]
BLAST of SMB domain-containing protein vs. Ensembl Celegans
Match: R17.3 (pep chromosome:WBcel235:III:10835014:10839451:1 gene:WBGene00011269.1 transcript:R17.3b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:R17.3)

HSP 1 Score: 70.8626 bits (172), Expect = 2.606e-13
Identity = 32/78 (41.03%), Postives = 46/78 (58.97%), Query Frame = 1 
Query:  280 KCFCDEHCVKSKDCCSDYKRLCSTKAINCILSNWGQWSPCSVD---CGAGVQTRFRKVIIPQQHNGRTCDHTEQARFC 504
            +C+CDEHCV   DCCSDY  +C  +  +C+L++W  W+ C+ D   CG G Q R R VI   +  G  C+  ++ R C
Sbjct:  207 ECYCDEHCVTLGDCCSDYTFVCPPR--DCVLTDWDSWTQCTADNGTCGIGTQKRLRHVIQHAERGGAACEPLKEMRTC 282
[Close]
BLAST of SMB domain-containing protein vs. Ensembl Fly
Match: CG42339 (gene:FBgn0259241 transcript:FBtr0299862)

HSP 1 Score: 70.0922 bits (170), Expect = 6.093e-13
Identity = 48/148 (32.43%), Postives = 73/148 (49.32%), Query Frame = 1 
Query:  139 ALSLPAFRLIF----GSCWIKSENRLTCCQGKNHTC----HGFDKIGSKWAGRQIKCFCDEHCVKSKDCCSDYKRLCSTKAINCILSNWGQWSPCSVDCGAGVQTRFRKVIIPQQHNGRTCDHTEQARFCHNNSC------SILRRVA 540
            A+ LP  +L+     GSC    E +L CC G++ +C       + I    + +   C+CD  C+K  DCC D+K  C    ++C + +WG WS C   CG G+ TR R+++   Q+ G+ C   +Q R C    C       ILR +A
Sbjct:    9 AVILPQRQLLPFVSGGSC---REAQL-CCNGRDSSCVVQKAPINAIIEDLSDK--PCYCDHACLKLGDCCDDFKDHCGV--LDCQVGDWGAWSECDRSCGTGMMTRNRQILQAAQNGGKHCPTLQQKRSCQGYRCHGHHDKKILREMA 148
[Close]
BLAST of SMB domain-containing protein vs. Ensembl Zebrafish
Match: si:dkey-178e17.3 (si:dkey-178e17.3 [Source:ZFIN;Acc:ZDB-GENE-081104-335])

HSP 1 Score: 88.1965 bits (217), Expect = 7.944e-20
Identity = 77/293 (26.28%), Postives = 122/293 (41.64%), Query Frame = 1 
Query:  166 IFGSCWIKSENRL--TCCQGKNHTCHGFDKIGSKWAGRQIKCFCDEHCVKSKDCCSDYKRLCSTKAINCILSNWGQWSPCSVDCGAGVQTRFRKVIIPQQHNGRTCDHTEQAR--FCHNNSCSILRRVAXXXXXXXXXXXXXXXXXXTEIHLIPKLERNIDTRKLISNRFGRNGKIYMADLSSRNNADPK--RNVYCATYQITNSTSSCKVWKDLSKLEQIYWKSHSERLNNGQRVCLTCSSHSDNNYKCFEGNKLNNLNK-WTAVRSDNCYGQFRMIETPKTCHCPNGSLSY 1023
            +   C     NR+  TCC G+N+ C       S  + R+  C+CD +C +S DCC DY    +  A +C ++ WG WSPCS  CGAG   R R+V  P ++ G  C   +Q R  F   ++CS  + VA                                  K++ + F RN K    D   R +   K  +  YC   ++  ++++CKV            +  S  L + + VC+ C S +        G+ L N+   W A ++  C G +      + C CP+ S+ +
Sbjct:    6 VSAVCEAGCANRIDPTCCPGRNNDC-------SDRSFRRTVCYCDTYCRRSGDCCEDYN---TVSAKDCEVTLWGAWSPCSSVCGAGTTERSRQVATPPRNGGTPCPDLKQRRGCFAPTDTCSAAKEVA----------------------------------KILPDSFKRNFK----DPWRRPHMLMKEEKKSYCVQMRVKQASAACKV------------RPWSAGLIHERSVCVECQSDAMATDNRCRGDGLQNIRTFWAAAQAPGCSGSWVRESLTENCRCPSYSVIF 238
[Close]
BLAST of SMB domain-containing protein vs. Ensembl Zebrafish
Match: SBSPON (somatomedin B and thrombospondin type 1 domain containing [Source:NCBI gene;Acc:100151218])

HSP 1 Score: 73.9442 bits (180), Expect = 1.177e-14
Identity = 69/278 (24.82%), Postives = 106/278 (38.13%), Query Frame = 1 
Query:  208 CCQGKNHTCHGFDKIGSKWAGRQI--KCFCDEHCVKSKDCCSDYKRLCSTKAINCILSNWGQWSPCSVDCGAGVQTRFRKVIIPQQHNGRTCDHTEQARFC------HNNSCSILRRVAXXXXXXXXXXXXXXXXXXTEIHLIPKLERNIDTRKLISNRFGRNGKIYMADLSSRNNADPKRNVYCATYQITNSTSSCKVWKDLSKLEQIYWKSHSERLNNGQRVCLTCSSHSDNNYKCFEGNKL---NNLNKWTAVRSDNCYGQFRMIETPKTCHCPN 1008
            CCQG + TC   D     W    +   C+CDE C+K+KDCC DY   C  +   C++S W  WS C+  C    + R R V    Q+NG  C   E+   C          CS  +  A                       I  +E +           GR  ++Y A         P    +C  +++ + T+ C         E   +    + L  G  VC+ C   +++++ C     L   N+L  W AV +  C G +R ++  + C CP 
Sbjct:   32 CCQGSDFTCFTTD-----WRMDHVYGTCYCDEKCLKTKDCCFDYPAECPAQP--CVVSEWSNWSGCAQPCQPSFRVRRRNVERLPQNNGEACLSLEEQAGCMEYQDHQGQFCSQTQGAA----------------------FITTMEYSK----------GRTHELYGA---------PVDAGFCMEFKMESLTAQCMG-------ENRPYARWMQYLREGYTVCVACQPPANHSWGCQGDGNLAERNDLLHWQAVGNPPCRGTWRKVQRLQHCSCPQ 254
[Close]
BLAST of SMB domain-containing protein vs. Ensembl Zebrafish
Match: si:dkey-178e17.3 (si:dkey-178e17.3 [Source:ZFIN;Acc:ZDB-GENE-081104-335])

HSP 1 Score: 63.5438 bits (153), Expect = 1.486e-11
Identity = 56/228 (24.56%), Postives = 91/228 (39.91%), Query Frame = 1 
Query:  355 AINCILSNWGQWSPCSVDCGAGVQTRFRKVIIPQQHNGRTCDHTEQAR--FCHNNSCSILRRVAXXXXXXXXXXXXXXXXXXTEIHLIPKLERNIDTRKLISNRFGRNGKIYMADLSSRNNADPK--RNVYCATYQITNSTSSCKVWKDLSKLEQIYWKSHSERLNNGQRVCLTCSSHSDNNYKCFEGNKLNNLNK-WTAVRSDNCYGQFRMIETPKTCHCPNGSLSY 1023
            A +C ++ WG WSPCS  CGAG   R R+V  P ++ G  C   +Q R  F   ++CS  + VA                                  K++ + F RN K    D   R +   K  +  YC   ++  ++++CKV            +  S  L + + VC+ C S +        G+ L N+   W A ++  C G +      + C CP+ S+ +
Sbjct:    7 AKDCEVTLWGAWSPCSSVCGAGTTERSRQVATPPRNGGTPCPDLKQRRGCFAPTDTCSAAKEVA----------------------------------KILPDSFKRNFK----DPWRRPHMLMKEEKKSYCVQMRVKQASAACKV------------RPWSAGLIHERSVCVECQSDAMATDNRCRGDGLQNIRTFWAAAQAPGCSGSWVRESLTENCRCPSYSVIF 184
[Close]
BLAST of SMB domain-containing protein vs. Ensembl Zebrafish
Match: si:dkey-7k24.5 (si:dkey-7k24.5 [Source:ZFIN;Acc:ZDB-GENE-131127-626])

HSP 1 Score: 60.4622 bits (145), Expect = 6.038e-10
Identity = 67/286 (23.43%), Postives = 110/286 (38.46%), Query Frame = 1 
Query:  208 CCQGKNHTCHGFDKIGSKWAGRQIKCFCDEHCVKSKDCCSDYKRLCSTKAINCILSNWGQWSPCSVDCGAGVQTRFRKVIIPQQHNGRTCDHTEQARFC---HNNSCSILRRVAXXXXXXXXXXXXXXXXXXTEIHLIPKLERNIDTRKLISNRFGRNGKIYMADLSSRNNADPKRNV------YCATYQITNSTSSCKVWKDLSKLEQIYWKSHS---ERLNNGQRVCLTCSSHSDNNYKCFEGNKLNNLN-------KWTAVRSDNCYGQFRMIETPKTCHCPN 1008
            CC G+N +C   D    +  G   +C+CD+ C  + DCC DY   C   A++C++S W  WS C   C   +++R R+VI   ++ G  C   +Q   C   H+     L+                         L+P L        + +  +G              NA  KR V      YC  +++T+ T+ C          Q  + SH+     L  G +VC+ C   +    + +      N+        +W AV +  C G +R +   ++C CP 
Sbjct:   49 CCIGQNQSCISEDWRKDRSFG---ECYCDQACKTTLDCCHDYDLAC--PAVSCVVSEWSLWSGCLEPCKPTLRSRRRQVIQEARNGGEPCPSLQQTAGCAEYHDQHGPCLQS------------------------LVPAL--------ITTGGYG--------------NARKKREVLDNITGYCVEFELTSLTAGC----------QRSFSSHTRWMRYLKEGHQVCVECQPPALTPGQRYCSGDGENMGYDRSVSLQWQAVGNSQCRGVWRRVRRRESCSCPT 273
[Close]
BLAST of SMB domain-containing protein vs. Ensembl Zebrafish
Match: si:dkey-7k24.5 (si:dkey-7k24.5 [Source:ZFIN;Acc:ZDB-GENE-131127-626])

HSP 1 Score: 60.4622 bits (145), Expect = 6.038e-10
Identity = 67/286 (23.43%), Postives = 110/286 (38.46%), Query Frame = 1 
Query:  208 CCQGKNHTCHGFDKIGSKWAGRQIKCFCDEHCVKSKDCCSDYKRLCSTKAINCILSNWGQWSPCSVDCGAGVQTRFRKVIIPQQHNGRTCDHTEQARFC---HNNSCSILRRVAXXXXXXXXXXXXXXXXXXTEIHLIPKLERNIDTRKLISNRFGRNGKIYMADLSSRNNADPKRNV------YCATYQITNSTSSCKVWKDLSKLEQIYWKSHS---ERLNNGQRVCLTCSSHSDNNYKCFEGNKLNNLN-------KWTAVRSDNCYGQFRMIETPKTCHCPN 1008
            CC G+N +C   D    +  G   +C+CD+ C  + DCC DY   C   A++C++S W  WS C   C   +++R R+VI   ++ G  C   +Q   C   H+     L+                         L+P L        + +  +G              NA  KR V      YC  +++T+ T+ C          Q  + SH+     L  G +VC+ C   +    + +      N+        +W AV +  C G +R +   ++C CP 
Sbjct:   49 CCIGQNQSCISEDWRKDRSFG---ECYCDQACKTTLDCCHDYDLAC--PAVSCVVSEWSLWSGCLEPCKPTLRSRRRQVIQEARNGGEPCPSLQQTAGCAEYHDQHGPCLQS------------------------LVPAL--------ITTGGYG--------------NARKKREVLDNITGYCVEFELTSLTAGC----------QRSFSSHTRWMRYLKEGHQVCVECQPPALTPGQRYCSGDGENMGYDRSVSLQWQAVGNSQCRGVWRRVRRRESCSCPT 273
[Close]
BLAST of SMB domain-containing protein vs. Ensembl Xenopus
Match: fam107a (family with sequence similarity 107 member A [Source:Xenbase;Acc:XB-GENE-986180])

HSP 1 Score: 82.0333 bits (201), Expect = 2.543e-17
Identity = 67/301 (22.26%), Postives = 114/301 (37.87%), Query Frame = 1 
Query:  124 WYLLI---ALSLPAFRLIFGSCWIKSENRLTCCQGKNHTCHGFDKIGSKWAGRQIKCFCDEHCVKSKDCCSDYKRLCSTKAINCILSNWGQWSPCSVDCGAGVQTRFRKVIIPQQHNGRTCDHTEQARFCHNNSCSILRRVAXXXXXXXXXXXXXXXXXXTEIHLIPKLERNIDTRKLISNRFGRNGKI----YMADLSSRNNADPKRNVYCATYQITNSTSSCKVWKDLSKLEQIYWKSHSERLNNGQRVCLTCSSHSDNNYKCFEGNKLNNLNK-WTAVRSDNCYGQFRMIETPKTCHC 1002
            W LL    AL +P  R    +C  ++  +  CC G+N+ C    + G         C+CD +C +S DCC DY+  C     +C++  WG WS CS  CG G + R R+V++P    G  C    Q   C+                                   P    + D  K++ + F R+ +     Y+  +  R  +      YC  +++ +    C++            +  S +L   Q VC+ C   +  +    +G+ L  +   W A    +C G +   +  + C C
Sbjct:    9 WLLLCSVWALHIPGGR---SACARRAHPK--CCPGRNNACTAPSRTGPT-------CYCDSYCTRSGDCCQDYRSQCGGSVSHCVVGPWGSWSECSSRCGIGSRERTRQVVVPPSSGGSPCPDLRQRCGCYGGD--------------------------------PDCHMSTDVAKILPDSFKRDFRDPWRRYLTTVQERAPS------YCVYFRLKHVGLGCQL------------QGWSRQLIREQLVCVECQKEAAGSNGRCQGDGLAGVRTFWAAASLSSCQGSWVQEDLREHCTC 247
[Close]
BLAST of SMB domain-containing protein vs. Ensembl Xenopus
Match: SBSPON (somatomedin B and thrombospondin type 1 domain containing [Source:NCBI gene;Acc:100489582])

HSP 1 Score: 77.0258 bits (188), Expect = 1.682e-15
Identity = 70/297 (23.57%), Postives = 115/297 (38.72%), Query Frame = 1 
Query:  124 WYLLIALSLPAFRLIFGSCWIKSENRLTCCQGKNHTCHGFDKIGSKWAGRQIKCFCDEHCVKSKDCCSDYKRLCSTKAINCILSNWGQWSPCSVDCGAGVQTRFRKVIIPQQHNGRTCDHTEQARFCHNNSCSILRRVAXXXXXXXXXXXXXXXXXXTEIHLIPKLERNIDTRKLISNRFGRNGKIYMADLSSRNNADPKRNVYCATYQITNSTSSCKVWKDLSKLEQIYWKSHSERLNNGQRVCLTCSSHSDN--NYKCF-EGNKLNNLNKWTAVRSDNCYGQFRMIETPKTCHCP 1005
            W LL+ L++   R   G C   ++    CC+G++  C        +  G    CFCD+ C  + DCC DY + C  +A  CI+  W  WS C+  C   ++ R R+V+   ++ G  C   E+   C     S     A+                      I   E N   R+                LS     + +   YC  +Q+ + +  C +           W  +   L  G  VC+ C   + N  N++C+ +G   N L  W AV +  C G ++ ++  ++C CP
Sbjct:   12 WTLLLGLAV-LIRSAEGGCMEAAK----CCRGRDMNCTSQGWRLDRLYG---TCFCDQACGLTGDCCFDYSQACPARA--CIVGEWSHWSGCADPCTPALRVRRRQVVQEPENGGNPCPALEEKAGCLEYFTSQGTECAQSHVTA----------------FITTFEYNKSRRRRA--------------LSPNWATEKEDAGYCVEFQVKSLSQDCLI----ESRPHARWMQY---LREGYTVCVACQHPAMNMRNHRCYGDGRNANGLLHWEAVGNPQCQGTWKKLKEVESCSCP 261
[Close]
BLAST of SMB domain-containing protein vs. Ensembl Xenopus
Match: THSD7A (thrombospondin type 1 domain containing 7A [Source:NCBI gene;Acc:100495599])

HSP 1 Score: 49.6766 bits (117), Expect = 7.336e-6
Identity = 28/57 (49.12%), Postives = 31/57 (54.39%), Query Frame = 1 
Query:  355 AINCILSNWGQWSPCSVDCG-AGVQTRFRKVIIPQQHNGRTCD-HTEQARFCHNNSC 519
             INC LS W  WS CS DCG AG   R R VI P Q +GR C    EQ++ C    C
Sbjct: 1253 PINCQLSEWSPWSKCSKDCGLAGKMLRNRTVIQPSQGDGRPCPSQMEQSKPCPVKPC 1309
[Close]
BLAST of SMB domain-containing protein vs. Ensembl Xenopus
Match: THSD7A (thrombospondin type 1 domain containing 7A [Source:NCBI gene;Acc:100495599])

HSP 1 Score: 49.6766 bits (117), Expect = 7.798e-6
Identity = 28/57 (49.12%), Postives = 31/57 (54.39%), Query Frame = 1 
Query:  355 AINCILSNWGQWSPCSVDCG-AGVQTRFRKVIIPQQHNGRTCD-HTEQARFCHNNSC 519
             INC LS W  WS CS DCG AG   R R VI P Q +GR C    EQ++ C    C
Sbjct: 1253 PINCQLSEWSPWSKCSKDCGLAGKMLRNRTVIQPSQGDGRPCPSQMEQSKPCPVKPC 1309
[Close]
BLAST of SMB domain-containing protein vs. Ensembl Xenopus
Match: THSD7A (thrombospondin type 1 domain containing 7A [Source:NCBI gene;Acc:100495599])

HSP 1 Score: 49.6766 bits (117), Expect = 8.116e-6
Identity = 28/57 (49.12%), Postives = 31/57 (54.39%), Query Frame = 1 
Query:  355 AINCILSNWGQWSPCSVDCG-AGVQTRFRKVIIPQQHNGRTCD-HTEQARFCHNNSC 519
             INC LS W  WS CS DCG AG   R R VI P Q +GR C    EQ++ C    C
Sbjct: 1240 PINCQLSEWSPWSKCSKDCGLAGKMLRNRTVIQPSQGDGRPCPSQMEQSKPCPVKPC 1296
[Close]
BLAST of SMB domain-containing protein vs. Ensembl Mouse
Match: Sbspon (somatomedin B and thrombospondin, type 1 domain containing [Source:MGI Symbol;Acc:MGI:2684952])

HSP 1 Score: 50.8322 bits (120), Expect = 9.091e-7
Identity = 70/305 (22.95%), Postives = 111/305 (36.39%), Query Frame = 1 
Query:  124 WYLLIALSLPAFRLIFGSCWIKSENRLTCCQGKNHTCHG----FDKIGSKWAGRQIKCFCDEHCVKSKDCCSDYKRLCSTKAINCILSNWGQWSPCSVDCGAGVQTRFRKVIIPQQHNGRTCDHTEQARFCHNNSCSILRRVAXXXXXXXXXXXXXXXXXXTEIHLIPKLERNIDTRKLISNRFGRNGKIYMADLSSRNNADPKRNVYCATYQITNSTSSCKVWKDLSKLEQIYWKSHSERLNNGQRVCLTCSSHSDN--NYKCFEGNKL----NNLNKWTAVRSDNCYGQFRMIETPKTCHCPN 1008
            W +L AL+    RL  G+    +E    CC G++  C       D++          CFCD+ C  + DCC DY R C  +   C +  W  WS C+  C    + R R V     + G  C   E+   C   S S  +                          +P          + S+ F  N K  +  +S + +   K   YC  ++  + T  C     L       W  +   L  G  VC+ C   + N  + +C  G+ L    N   +W A+ +  C G ++ +   + C CP+
Sbjct:    5 WMVLCALA----RLWPGALAGCAEAG-RCCPGRDPACFARGWRLDRVYGT-------CFCDQACRLTGDCCFDYDRACPARP--CFVGEWSPWSGCAGQCQPTTRVRRRSVRQEPLNGGAPCPPLEERAGCLEYSSSQSQDCGH--------------------SFVPAF--------ITSSVF--NKKRIIQAVSPQWSTHTKDAGYCMEFKTESLTPHCA----LVNSPLTRWMQY---LREGYTVCVDCQPPAMNSVSLRC-SGDGLDSDGNQTLRWQAIGNPRCQGTWKKVRRVEQCSCPD 257
[Close]
BLAST of SMB domain-containing protein vs. Ensembl Mouse
Match: Adgrb2 (adhesion G protein-coupled receptor B2 [Source:MGI Symbol;Acc:MGI:2451244])

HSP 1 Score: 50.8322 bits (120), Expect = 2.370e-6
Identity = 28/89 (31.46%), Postives = 42/89 (47.19%), Query Frame = 1 
Query:  304 VKSKDCCSD-YKRLCS-------------TKAINCILSNWGQWSPCSVDCGAGVQTRFRKVIIPQQHNGRTCDHTE-QARFCHNNSCSI 525
            V+++ C S  Y  LCS             T  ++ +   WG WS CS  CG G ++R R   +P QH G+ C+  E Q + C   +C +
Sbjct:  322 VRTRSCVSSPYGTLCSGPLRETRPCNNSATCPVHGVWEEWGSWSLCSRSCGRGSRSRMR-TCVPPQHGGKACEGPELQTKLCSMAACPV 409
[Close]
BLAST of SMB domain-containing protein vs. Ensembl Mouse
Match: Adgrb2 (adhesion G protein-coupled receptor B2 [Source:MGI Symbol;Acc:MGI:2451244])

HSP 1 Score: 50.8322 bits (120), Expect = 2.390e-6
Identity = 28/89 (31.46%), Postives = 42/89 (47.19%), Query Frame = 1 
Query:  304 VKSKDCCSD-YKRLCS-------------TKAINCILSNWGQWSPCSVDCGAGVQTRFRKVIIPQQHNGRTCDHTE-QARFCHNNSCSI 525
            V+++ C S  Y  LCS             T  ++ +   WG WS CS  CG G ++R R   +P QH G+ C+  E Q + C   +C +
Sbjct:  322 VRTRSCVSSPYGTLCSGPLRETRPCNNSATCPVHGVWEEWGSWSLCSRSCGRGSRSRMR-TCVPPQHGGKACEGPELQTKLCSMAACPV 409
[Close]
BLAST of SMB domain-containing protein vs. Ensembl Mouse
Match: Adgrb2 (adhesion G protein-coupled receptor B2 [Source:MGI Symbol;Acc:MGI:2451244])

HSP 1 Score: 50.8322 bits (120), Expect = 2.435e-6
Identity = 28/89 (31.46%), Postives = 42/89 (47.19%), Query Frame = 1 
Query:  304 VKSKDCCSD-YKRLCS-------------TKAINCILSNWGQWSPCSVDCGAGVQTRFRKVIIPQQHNGRTCDHTE-QARFCHNNSCSI 525
            V+++ C S  Y  LCS             T  ++ +   WG WS CS  CG G ++R R   +P QH G+ C+  E Q + C   +C +
Sbjct:  322 VRTRSCVSSPYGTLCSGPLRETRPCNNSATCPVHGVWEEWGSWSLCSRSCGRGSRSRMR-TCVPPQHGGKACEGPELQTKLCSMAACPV 409
[Close]
BLAST of SMB domain-containing protein vs. Ensembl Mouse
Match: Adgrb2 (adhesion G protein-coupled receptor B2 [Source:MGI Symbol;Acc:MGI:2451244])

HSP 1 Score: 50.8322 bits (120), Expect = 2.547e-6
Identity = 28/89 (31.46%), Postives = 42/89 (47.19%), Query Frame = 1 
Query:  304 VKSKDCCSD-YKRLCS-------------TKAINCILSNWGQWSPCSVDCGAGVQTRFRKVIIPQQHNGRTCDHTE-QARFCHNNSCSI 525
            V+++ C S  Y  LCS             T  ++ +   WG WS CS  CG G ++R R   +P QH G+ C+  E Q + C   +C +
Sbjct:  322 VRTRSCVSSPYGTLCSGPLRETRPCNNSATCPVHGVWEEWGSWSLCSRSCGRGSRSRMR-TCVPPQHGGKACEGPELQTKLCSMAACPV 409
[Close]
BLAST of SMB domain-containing protein vs. UniProt/SwissProt
Match: sp|Q32L50|SBSPO_BOVIN (Somatomedin-B and thrombospondin type-1 domain-containing protein OS=Bos taurus OX=9913 GN=SBSPON PE=2 SV=2)

HSP 1 Score: 57.3806 bits (137), Expect = 3.840e-8
Identity = 33/101 (32.67%), Postives = 45/101 (44.55%), Query Frame = 1 
Query:  208 CCQGKNHTCHGFDKIGSKWAGRQI--KCFCDEHCVKSKDCCSDYKRLCSTKAINCILSNWGQWSPCSVDCGAGVQTRFRKVIIPQQHNGRTCDHTEQARFC 504
            CC G++  C       S W   ++   CFCD+ C  + DCC DY R C  +   CI+  W  WS C+  C    + R R V    Q+ G  C   E+   C
Sbjct:   28 CCPGRDPAC-----FASGWRQDRVYGTCFCDQACRLTGDCCFDYARACPARP--CIVGEWSPWSGCASQCRPTARVRRRAVQQEPQNGGEPCPALEERAGC 121
[Close]
BLAST of SMB domain-containing protein vs. UniProt/SwissProt
Match: sp|Q8IVN8|SBSPO_HUMAN (Somatomedin-B and thrombospondin type-1 domain-containing protein OS=Homo sapiens OX=9606 GN=SBSPON PE=1 SV=2)

HSP 1 Score: 53.1434 bits (126), Expect = 1.246e-6
Identity = 32/107 (29.91%), Postives = 44/107 (41.12%), Query Frame = 1 
Query:  208 CCQGKNHTCHG----FDKIGSKWAGRQIKCFCDEHCVKSKDCCSDYKRLCSTKAINCILSNWGQWSPCSVDCGAGVQTRFRKVIIPQQHNGRTCDHTEQARFCHNNS 516
            CC G++  C       D++          CFCD+ C  + DCC DY R C  +   C +  W  WS C+  C    + R R V    Q+ G  C   E+   C   S
Sbjct:   28 CCPGRDPACFARGWRLDRVYGT-------CFCDQACRFTGDCCFDYDRACPARP--CFVGEWSPWSGCADQCKPTTRVRRRSVQQEPQNGGAPCPPLEERAGCLEYS 125
[Close]
BLAST of SMB domain-containing protein vs. UniProt/SwissProt
Match: sp|Q3UPR9|SBSPO_MOUSE (Somatomedin-B and thrombospondin type-1 domain-containing protein OS=Mus musculus OX=10090 GN=Sbspon PE=2 SV=1)

HSP 1 Score: 50.8322 bits (120), Expect = 6.359e-6
Identity = 70/305 (22.95%), Postives = 111/305 (36.39%), Query Frame = 1 
Query:  124 WYLLIALSLPAFRLIFGSCWIKSENRLTCCQGKNHTCHG----FDKIGSKWAGRQIKCFCDEHCVKSKDCCSDYKRLCSTKAINCILSNWGQWSPCSVDCGAGVQTRFRKVIIPQQHNGRTCDHTEQARFCHNNSCSILRRVAXXXXXXXXXXXXXXXXXXTEIHLIPKLERNIDTRKLISNRFGRNGKIYMADLSSRNNADPKRNVYCATYQITNSTSSCKVWKDLSKLEQIYWKSHSERLNNGQRVCLTCSSHSDN--NYKCFEGNKL----NNLNKWTAVRSDNCYGQFRMIETPKTCHCPN 1008
            W +L AL+    RL  G+    +E    CC G++  C       D++          CFCD+ C  + DCC DY R C  +   C +  W  WS C+  C    + R R V     + G  C   E+   C   S S  +                          +P          + S+ F  N K  +  +S + +   K   YC  ++  + T  C     L       W  +   L  G  VC+ C   + N  + +C  G+ L    N   +W A+ +  C G ++ +   + C CP+
Sbjct:    5 WMVLCALA----RLWPGALAGCAEAG-RCCPGRDPACFARGWRLDRVYGT-------CFCDQACRLTGDCCFDYDRACPARP--CFVGEWSPWSGCAGQCQPTTRVRRRSVRQEPLNGGAPCPPLEERAGCLEYSSSQSQDCGH--------------------SFVPAF--------ITSSVF--NKKRIIQAVSPQWSTHTKDAGYCMEFKTESLTPHCA----LVNSPLTRWMQY---LREGYTVCVDCQPPAMNSVSLRC-SGDGLDSDGNQTLRWQAIGNPRCQGTWKKVRRVEQCSCPD 257
[Close]
BLAST of SMB domain-containing protein vs. TrEMBL
Match: A0A0X3P2U1 (Somatomedin-B and thrombospondin type-1 domain-containing protein OS=Schistocephalus solidus OX=70667 GN=SBSPO PE=4 SV=1)

HSP 1 Score: 130.183 bits (326), Expect = 1.208e-30
Identity = 97/343 (28.28%), Postives = 146/343 (42.57%), Query Frame = 1 
Query:  172 GSCWIKSENRLTCCQGKNHTCHGFDKIGSKW-----------AGRQIKCFCDEHCVKSKDCCSDYKRLCSTKAINCILSNWGQWSPCSVDCGAGVQTRFRKVIIPQQHNGRTCDHTEQARFCHNNSCSILRRVAXXXXXXXXXXXXXXXXXXTEI-HLIPKLERNIDTRKLISNRFGRNGKIYMADLSSRNNAD-PKRNVYCATYQITNSTSSCK-------------VWKDLSKLEQIY-----------------------------WKSHSERLNNGQRVCLTCSSH---SDNNYKCFEGNKLNNLNKWTAVRSDNCYGQFRMIETPKT-CHCPNGSLSY 1023
            GSC   S+    CC G+   C G   + + +            G   +C+CDEHC+ ++DCC DY+++C+   I+C +S W  WSPCS DCG G Q R R +I   ++ G  C   E+ R C     SI R V        S S+ R     TE+ +L+P      D  KL   R+    K+Y+  L  +N  + P    YC  Y+I  +  SC+              W D  +   ++                             W   ++ L+ GQ +C TC       D + +C     L  ++KW A+R+ +C G FRMI  P++ C C  G  S+
Sbjct:   30 GSC-RNSDGSAKCCVGRKADCAGQKIVFASFHHLNFSPLKRTVGTNQRCYCDEHCLLTEDCCPDYRQVCNKPKIDCRVSAWSNWSPCSNDCGPGKQRRSRLIIELPRNGGDQCPFLEETRKCDGEHGSICRFV-------RSGSRMRRLDASTEVANLLPVQGDIQDQLKLFDMRWDIRRKLYLVQLIQQNRTEVPDPEPYCVMYKIVQANPSCQKRNSGWSFSLDDDAWTDRRRRRSVWSSGWQSNRRTLTKFAGGEPKQAARALVHPWLRAADLLHPGQEICATCYPQYMRKDRDNRCPGTGYLGMVSKWRALRTQDCRGTFRMISMPRSACTCSAGPASF 364
[Close]
BLAST of SMB domain-containing protein vs. TrEMBL
Match: G4VAK5 (SMB domain-containing protein OS=Schistosoma mansoni OX=6183 GN=Smp_060030 PE=4 SV=1)

HSP 1 Score: 120.939 bits (302), Expect = 4.911e-27
Identity = 91/386 (23.58%), Postives = 147/386 (38.08%), Query Frame = 1 
Query:  115 IMNWYLLIA--LSLPAFRLIFGSCWIKSENRLTCCQGKNHTCHGFDKIGSKWAGRQI----------------KCFCDEHCVKSKDCCSDYKRLCSTKAINCILSNWGQWSPCSVDCGAGVQTRFRKVIIPQQHNGRTCDHTEQARFCHNNSCSILRRVAXXXXXXXXXXXXXXXXXXTEIHLIPKLERNIDTRKLISNRFGRNGKIYMADLSSRNNAD-PKRNVYCATYQITNSTSSCK----VWKDLSKLEQIY-------WKSH----------------------------------------------SERLNNGQRVCLTCSS---HSDNNYKCFEGNKLNNLNKWTAVRSDNCYGQFRMIETP-KTCHCPNGSLSYHVV 1032
             ++W  L +  +++    L+  +  ++      CC G+   C  +   G     R                  +CFCDE CV + DCC DY+  C    ++C +S WG W+ C   CG  V TR+R+V I   +NG+ C    + R C  ++C+  R                        HL+P     +D  +    RF    K+Y+  L   N  + P+ + YCA Y+IT +  +C+    +W+  S  +Q         +K H                                              S  L  GQ++C+TC       D  Y+C      N   +W A+R+ +C G+FRM+  P ++C C  G  S+  V
Sbjct:   17 FLHWVTLFSFYITINQISLVISNGCLQPNGMSICCAGREEKCFVYKSTGQSSISRYYPWRKYRSVAGHSSPRGRCFCDESCVITGDCCHDYQFTCQKTKVDCTVSEWGPWTSCEYACGQSVSTRYRQVQIKPSNNGKPCPELNETRPCIGHNCASKR----FGRSGTLMVPYVYDIKAEVAHLLPVRGDVLDLTRRYDMRFDVRRKLYLGRLIKMNKTEQPEPDPYCAVYEITYTNQACQTQNLLWQFSSSRDQYPYYYYPNRYKRHNGYNGQSITFSRKSFLHERQYNKLGNTGLNKNWEDDYSNSESWITHSALLTPGQQICVTCYPTYMREDLGYRCTGSGLPNIETRWRALRTSDCQGRFRMVSIPQRSCTCGRGVASFVFV 398
[Close]
BLAST of SMB domain-containing protein vs. TrEMBL
Match: A0A0R3U3F2 (SMB domain-containing protein OS=Mesocestoides corti OX=53468 GN=MCOS_LOCUS1091 PE=4 SV=1)

HSP 1 Score: 119.013 bits (297), Expect = 9.390e-27
Identity = 93/337 (27.60%), Postives = 144/337 (42.73%), Query Frame = 1 
Query:  124 WYLLIALSLPAFRLIFGSCWIKSENRLTCCQG---------KNHTCHGFDKIGSKWAGR------QIKCFCDEHCVKSKDCCSDYKRLCSTKAINCILSNWGQWSPCSVDCGAGVQTRFRKVIIPQQHNGRTCDHTEQARFCHNNSCSILRRVAXXXXXXXXXXXXXXXXXXTEIHLIPKLERNIDTRKLISNRFGRNGKIYMADLSSRNNAD-PKRNVYCATYQITNSTSSCK--------VWKDLSKLEQIYWKSH---------SERLNNGQRVCLTCSS---HSDNNYKCFEGNKLNNLNKWTAVRSDNCYGQFRMIETP-KTCHCPNGSLSY 1023
            + +L+A S  A  L  GSC    +    CC G         K H  + +   G + A        +  CFCDE+CV++ DCC DY+ +C+   +NC +S W  WSPCS  CG G QTR R V     + G  C    ++R C  + CS  RRV + +   +   +   +      HL+P      +  K    R+    K+Y   L  +N  D P    YC  Y+I  +  +CK         W+  S+  Q Y+  +         S  +  GQ++C  C      +D   +C        +++W A+ + +C G FRM+  P + C C     S+
Sbjct:   10 FVVLLACSSLASALTHGSCR-NPDGTAICCTGRTNCEGVTKKAHATYVYSNSGYRTANNRPATVPKATCFCDEYCVRTNDCCRDYREVCAKPKVNCEVSAWSSWSPCSQQCGKGNQTRVRTVTREAVNGGDQCPLLMESRACKGHLCS-RRRVGRSEYNSYRYMELPAEVA----HLLPVHGDIEEAIKQFDMRWDIRRKLYYGRLIQQNKTDTPDPEPYCVYYEIVKANDACKGIGLHRRGAWRFPSRSLQHYFDRNLDVDHPWLSSTLMRPGQQICAVCYPKYMRADLGNRCPGTGYPGIISRWRALNTYDCQGTFRMVSMPQRACTCRRQPTSF 340
[Close]
BLAST of SMB domain-containing protein vs. TrEMBL
Match: A0A430QQ21 (SMB domain-containing protein OS=Schistosoma bovis OX=6184 GN=DC041_0003935 PE=4 SV=1)

HSP 1 Score: 116.701 bits (291), Expect = 2.221e-25
Identity = 87/379 (22.96%), Postives = 141/379 (37.20%), Query Frame = 1 
Query:  130 LLIALSLPAFRLIFGSCWIKSENRLTCCQGKNHTCHGFDKIGSKWAGRQI----------------KCFCDEHCVKSKDCCSDYKRLCSTKAINCILSNWGQWSPCSVDCGAGVQTRFRKVIIPQQHNGRTCDHTEQARFCHNNSCSILRRVAXXXXXXXXXXXXXXXXXXTEIHLIPKLERNIDTRKLISNRFGRNGKIYMADLSSRNNAD-PKRNVYCATYQITNSTSSCKVWKDLSKLEQ-------IYWKSHSERLNN--------------------------------------------------GQRVCLTCSS---HSDNNYKCFEGNKLNNLNKWTAVRSDNCYGQFRMIETP-KTCHCPNGSLSYHVV 1032
             L  +++    L+  +  ++      CC G+   C  +   G     R                  +C+CDE CV + DCC DY   C    ++C +S WG W+ C   CG  V TR+R++ I   +NG+ C    + R C  ++C+  R                        HL+P     +D  +    RF    K+Y+  L   N  + P+ + YCA Y+IT S  +C+    L +  Q        Y+ +  +R N+                                                  GQ++C+TC       D  Y+C      N   +W A+R+ +C G+FRM+  P ++C C  G  S+  V
Sbjct:   70 FLFYITINQISLVISNGCLQPNGMSICCAGREKKCFVYKSTGQSSISRYYPWKKYRSVAGHSSPRDRCYCDESCVITGDCCHDYHFTCQKTKVDCTVSEWGPWTSCEYTCGQSVSTRYRQIQIKPSNNGKPCPELNETRPCIGHNCASKR----FGRSGTLMVPYVYDIKAEVAHLLPVHGDVLDLTRRYDMRFDVRRKLYLGRLIKMNKTEQPEPDPYCAVYEITYSNQACQSQNLLWQFSQSRDLYPSYYYPNRYKRHNDYNGQSITFSRKSFLHKRQYSTVGNTGLNKNWEDNYSNSESWITHSALLTPGQQICVTCYPTYMREDLGYRCTGSGLPNVETRWRALRTSDCQGRFRMVSIPQRSCTCGRGVASFVFV 444
[Close]
BLAST of SMB domain-containing protein vs. TrEMBL
Match: C1LEZ0 (Putative spondin 99.0 OS=Schistosoma japonicum OX=6182 GN=EWB00_007457 PE=2 SV=1)

HSP 1 Score: 113.62 bits (283), Expect = 2.050e-24
Identity = 80/313 (25.56%), Postives = 127/313 (40.58%), Query Frame = 1 
Query:  280 KCFCDEHCVKSKDCCSDYKRLCSTKAINCILSNWGQWSPCSVDCGAGVQTRFRKVIIPQQHNGRTCDHTEQARFCHNNSCSILRRVAXXXXXXXXXXXXXXXXXXTEIHLIPKLERNIDTRKLISNRFGRNGKIYMADLSSRNNAD-PKRNVYCATYQITNSTSSCK----VWKDLSKLEQ---IYWKSHSER--------------------------------------------------LNNGQRVCLTCSS---HSDNNYKCFEGNKLNNLNKWTAVRSDNCYGQFRMIETP-KTCHCPNGSLSYHVV 1032
            +C+CDE CV + DCC DY  +C    ++C +S WG W+ C   CG  V TR+R+V I    NG+ C    + R C  ++C+  R                        HL+P     +D  +    RF    K+Y+  L   N  + P+ + YCA Y+IT +  +C+    +W+  S  +Q    Y+ +  +R                                                  L  GQ++C+TC       D  Y+C      N   +W A+R+ +C G+FR++  P ++C C  GS S+  V
Sbjct:   90 RCYCDESCVITGDCCHDYHYICQKTKVDCTVSEWGPWTSCEYACGHSVSTRYRQVQIKPSTNGKPCPELNETRPCIGHNCASKR----FGRSGTLMLPYIYDIKAEVAHLLPVRGDVLDLTRRYDMRFDVRRKLYLGRLIKMNKTEQPEPDPYCAIYEITYTNEACQTQNLLWQFSSSHDQYPSYYYPNRYKRHNSYNGQSVTFSRNTFLHERRYNLLGNHGMNKNWDNDYSNPESWSTHSGLLTPGQQICVTCYPTYMREDLGYRCTGSGLPNIETRWRALRTFDCQGRFRVVSMPQRSCTCGRGSASFVFV 398
[Close]
BLAST of SMB domain-containing protein vs. Ensembl Cavefish
Match: si:dkey-178e17.3 (somatomedin-B and thrombospondin type-1 domain-containing protein-like [Source:NCBI gene;Acc:103038119])

HSP 1 Score: 98.2117 bits (243), Expect = 2.601e-23
Identity = 73/279 (26.16%), Postives = 120/279 (43.01%), Query Frame = 1 
Query:  205 TCCQGKNHTCHGFDKIGSKWAGRQIKCFCDEHCVKSKDCCSDYKRLCS-TKAINCILSNWGQWSPCSVDCGAGVQTRFRKVIIPQQHNGRTCDHTEQARFC--HNNSCSILRRVAXXXXXXXXXXXXXXXXXXTEIHLIPKLERNIDTRKLISNRFGRNGKIYMADLSSRNNA--DPKRNVYCATYQITNSTSSCKVWKDLSKLEQIYWKSHSERLNNGQRVCLTCSSHSDNNYKCFEGNKLNNLNK-WTAVRSDNCYGQFRMIETPKTCHCPNGSLSY 1023
             CC G+N+ C   ++       R+  C+CD +C K+ DCC DY+++C  + AI+C +  WG WSPCS  CGAG   R R+V  P ++ G  C   +Q R C  H ++CS  + VA                                  K++ + F RN K    D   R +     +R  YC   ++   +++C++            K  S ++   + VC+ C S +        G+ L ++   W A  +  C G +      ++C+CP  SL +
Sbjct:   38 ACCTGRNNECAELNR-------RKTACYCDSYCEKTGDCCEDYRQVCQISAAIDCEVGEWGVWSPCSSVCGAGTTERSRQVTTPPRNGGSPCPDLKQRRGCLAHLDTCSTAKEVA----------------------------------KILPDSFKRNFK----DPWRRPHMLIKEERKSYCVNMRVKQVSAACRM------------KVWSSQMARERSVCVECQSDAMAADNRCRGDGLQSIRTFWAAASAPGCLGSWIRESWSESCYCPAHSLLF 259
[Close]
BLAST of SMB domain-containing protein vs. Ensembl Cavefish
Match: SBSPON (somatomedin B and thrombospondin type 1 domain containing [Source:NCBI gene;Acc:103035495])

HSP 1 Score: 70.0922 bits (170), Expect = 2.451e-13
Identity = 72/312 (23.08%), Postives = 120/312 (38.46%), Query Frame = 1 
Query:  115 IMNWY-LLIALSLPAFRLIFGSCWIKSENRLTCCQGKNHTCHGFDKIGSKWAGRQI--KCFCDEHCVKSKDCCSDYKRLCSTKAINCILSNWGQWSPCSVDCGAGVQTRFRKVIIPQQHNGRTCDHTEQARFC------HNNSCSILRRVAXXXXXXXXXXXXXXXXXXTEIHLIPKLERNIDTRKLISNRFGRNGKIYMADLSSRNNADPKRNVYCATYQITNSTSSCKVWKDLSKLEQIYWKSHSERLNNGQRVCLTCSSHSDNN--YKC-FEGNKLN--NLNKWTAVRSDNCYGQFRMIETPKTCHCPN 1008
            ++ W  +L+A     +    G C         CC GK+ TC   D     W   ++   C+CDE CV+SKDCC DY   C+ +   C++S W  WS C+  C    + R R + I  Q++G+ C   E+   C         SC   +  A                                   LI+     NG+I      +     P  + +C  +++ + +  C V           W  +   L  G  VC++C   + +N  + C  +G   N   + +W AV +  C G ++ ++  + C CP+
Sbjct:    6 VIRWASVLLATVFGPYHPAEGGC------SGQCCPGKDLTCSSLD-----WRSDRVYTTCYCDESCVRSKDCCFDYPTECTAQP--CVVSEWTHWSGCARPCQPSYRVRRRSIEIKPQNSGQACPALEERAGCMEYQDYEGQSCGHSQGPA-----------------------------------LITTMEYSNGRIAHVVYGT-----PVDSGFCMEFKVESLSRHCMV----ENKPHTRWMQY---LREGFVVCVSCQPPAISNRSHTCNGDGQSANRDTILQWQAVGNPRCRGTWKKVQKLQHCSCPS 257
[Close]
BLAST of SMB domain-containing protein vs. Ensembl Cavefish
Match: si:dkey-7k24.5 (somatomedin-B and thrombospondin type-1 domain-containing protein-like [Source:NCBI gene;Acc:103032161])

HSP 1 Score: 64.6994 bits (156), Expect = 1.703e-11
Identity = 40/130 (30.77%), Postives = 63/130 (48.46%), Query Frame = 1 
Query:  142 LSLPAFRLIFGSC----WIKSENRL-----TCCQGKNHTCHGFDKIGSKWAGRQIKCFCDEHCVKSKDCCSDYKRLCSTKAINCILSNWGQWSPCSVDCGAGVQTRFRKVIIPQQHNGRTCDHTEQARFC 504
            +S+P + ++  +     W+++E         CC G++ +CH     G +       C+CD+ C    DCC DY++ C   AI C++S W  WS CS  C A V+ R R+V+   Q+ G  C    Q   C
Sbjct:    1 MSVPVWSVLVLTLTLARWVEAEAEGCLPTGLCCSGRDSSCH---SQGWRTDRSHGDCYCDQACRTMLDCCHDYEQAC--PAIPCVVSEWSTWSGCSEPCKATVRVRERRVLQDAQNGGEPCPPLLQTAGC 125
[Close]
BLAST of SMB domain-containing protein vs. Ensembl Sea Lamprey
Match: si:dkey-178e17.3 (si:dkey-178e17.3 [Source:ZFIN;Acc:ZDB-GENE-081104-335])

HSP 1 Score: 61.6178 bits (148), Expect = 1.556e-11
Identity = 47/222 (21.17%), Postives = 84/222 (37.84%), Query Frame = 1 
Query:  355 AINCILSNWGQWSPCSVDCGAGVQTRFRKVIIPQQHNGRTCDHTEQARFCHNNSCSILRRVAXXXXXXXXXXXXXXXXXXTEIHLIPKLERNIDT-RKLISNRFGRNGKIYMADLSSRNNADPKRNVYCATYQITNSTSSCKVWKDLSKLEQIYWKSHSERLNNGQRVCLTCSSHS--DNNYKCFEGNKLNNLNK--WTAVRSDNCYGQFRMIETPKTCHCP 1005
            A +C +  WG WSPCS  CG G + R R+V +P  + G  C H  Q + C+++S  + + +                     +  +P + R+  T  K +++      +   A               C  +++ +++S C     ++   ++        L  G+RVC+ C   +      +C         N+  W AV    C G +        CHCP
Sbjct:    1 ATDCAVLGWGAWSPCSSACGVGSRERIRQVTVPPHNGGAKCPHLRQRQGCYSHSLQLCQGI--------------------RVTAVPFITRDAGTSSKTLADTTAHEPRTEFAS-------------SCVFFRVDDASSPCASRSAVAPWLRL--------LQAGRRVCVECQGEAVRRGEGRCSGDGVQGTSNRTFWAAVSVPGCRGSWLRERHHNDCHCP 181
[Close]
BLAST of SMB domain-containing protein vs. Ensembl Sea Lamprey
Match: si:dkey-178e17.3 (si:dkey-178e17.3 [Source:ZFIN;Acc:ZDB-GENE-081104-335])

HSP 1 Score: 53.9138 bits (128), Expect = 7.030e-9
Identity = 22/54 (40.74%), Postives = 32/54 (59.26%), Query Frame = 1 
Query:  355 AINCILSNWGQWSPCSVDCGAGVQTRFRKVIIPQQHNGRTCDHTEQARFCHNNS 516
            A +C +  WG WSPCS  CG G + R R+V +P  + G  C H  Q + C+++S
Sbjct:    1 ATDCAVLGWGAWSPCSSACGVGSRERIRQVTVPPHNGGAKCPHLRQRQGCYSHS 54
[Close]
BLAST of SMB domain-containing protein vs. Ensembl Nematostella
Match: EDO47504 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RLY4])

HSP 1 Score: 95.9005 bits (237), Expect = 8.144e-23
Identity = 80/278 (28.78%), Postives = 127/278 (45.68%), Query Frame = 1 
Query:  202 LTCCQGKNHTC--HGFDKIGSKWAGRQIKCFCDEHCVKSKDCCSDYKRL---CSTKAI-NCILSNWGQWSPCSVDCGAGVQTRFRKVII-PQQHNGRTCDHTEQARFCHNNSCSILRRVAXXXXXXXXXXXXXXXXXXTEIHLIPKLERNIDTRKLISNRFGRNGKIYMA--DLSSRNNADPKRNVYCATYQITNSTSSCKVWKDLSKLEQIYWKSHSERLNNGQRVCLTCSSHSDNNYKCFEGNKL-NNLNKWTAVRSDNCYGQ-FRMIETPKTCHC 1002
            LTCC+G+N TC    FD+  S+ + R   CFCDE C  + DCC D+K +   C  + + +C++S W +WSPCS  CG G++ R R+VI+ P Q  G+ C    Q R C    C     +A                     +++PK+       K + N++    +I  A   L+ R   + +R  YC  ++I +    C          Q  W S   +L+  + VC+ C S + N +   +G+ +   L  W AV   +C+G+  R+      C C
Sbjct:   33 LTCCKGRNSTCAVERFDEEESRPSNRPKVCFCDEFCEPAGDCCPDFKAVKEECKLQGVQDCVVSTWSRWSPCSHRCGVGMRKRSRRVIVRPSQRGGKECPPLRQKRGCFLEHCGKESGLA---------------------NILPKI------YKRLPNQY---EEILPAKKSLTLRQEKE-ERPSYCTLFKIESKHPYC----------QGTWAS---QLDPKKPVCVECQSSAMNKHGNCKGHGVTGELTSWFAVDIYSCHGEWIRLGPKMSPCKC 266
[Close]
BLAST of SMB domain-containing protein vs. Ensembl Nematostella
Match: EDO49895 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RF43])

HSP 1 Score: 48.9062 bits (115), Expect = 1.783e-6
Identity = 22/55 (40.00%), Postives = 32/55 (58.18%), Query Frame = 1 
Query:  358 INCILSNWGQWSPCSVDCGAGVQTRFRKVIIPQQHNGRTCDHTEQARFCHNNSCS 522
            I+C L++W +W+ CSV CG G Q R R +I   +H+G  C +  + R C    CS
Sbjct:  232 IDCQLTHWSKWTSCSVTCGVGEQIRGRDIIRVPEHDGIPCPNLYEHRPCARQRCS 286
[Close]
BLAST of SMB domain-containing protein vs. Ensembl Medaka
Match: si:dkey-178e17.3 (somatomedin-B and thrombospondin type-1 domain-containing protein [Source:NCBI gene;Acc:101155034])

HSP 1 Score: 101.293 bits (251), Expect = 9.851e-25
Identity = 72/275 (26.18%), Postives = 116/275 (42.18%), Query Frame = 1 
Query:  208 CCQGKNHTCHGFDKIGSKWAGRQIKCFCDEHCVKSKDCCSDYKRLCSTKAINCILSNWGQWSPCSVDCGAGVQTRFRKVIIPQQHNGRTCDHTEQARFCHNNS--CSILRRVAXXXXXXXXXXXXXXXXXXTEIHLIPKLERNIDTRKLISNRFGRNGKIYMADLSSRNNADPKRN-VYCATYQITNSTSSCKVWKDLSKLEQIYWKSHSERLNNGQRVCLTCSSHSDNNYKCFEGNKLNNLNKWTAVRSDNCYGQFRMIETPKTCHCPNGSLSY 1023
            CC G+N+ C+   +       R+  C+CD +C K+ DCC DY+ +C   AI+C++ +WG WS C+  CG G   R R+V +P ++ G  C    Q R C+ N+  CS  +                                     K++ + F RN K    D   R +   K    YC   ++  ++S+CK+            K  S +L   + +C  C S + +     EG+ L N+  W A  +  C G +    + + C CP  S+ Y
Sbjct:   12 CCSGRNNDCYESSR-------RKTVCYCDTYCQKTGDCCEDYRGVCQISAIDCVVGSWGAWSLCTSKCGVGSTERSRQVSVPPRNGGAPCPDLRQRRGCYGNAAVCSAAK-----------------------------------VAKILPDSFKRNFK----DPWRRPHMMIKEEKAYCVYLRVKQASSACKL------------KLWSAQLVRERLICAECQSDAMSKSDRCEGDGLKNITFWAAASAPGCQGSWVRESSSEHCRCPPYSVLY 228
[Close]
BLAST of SMB domain-containing protein vs. Ensembl Medaka
Match: SBSPON (somatomedin B and thrombospondin type 1 domain containing [Source:NCBI gene;Acc:101174055])

HSP 1 Score: 82.0333 bits (201), Expect = 1.660e-17
Identity = 73/305 (23.93%), Postives = 115/305 (37.70%), Query Frame = 1 
Query:  127 YLLIALSLPAFRLIFGSCWIKSENRLTCCQGKNHTCHGFDKIGSKWAGRQIKCFCDEHCVKSKDCCSDYKRLCSTKAINCILSNWGQWSPCSVDCGAGVQTRFRKVIIPQQHNGRTCDHTEQARFCHNNSCSILRRVAXXXXXXXXXXXXXXXXXXTEIHLIPKLERNIDTRKLISNRFGRNGKIYMADLSSRNNADPKRNVY--------CATYQITNSTSSCKVWKDLSKLEQIYWKSHSERLNNGQRVCLTCSSHSDNNYKCFEGNKLNNLNK----WTAVRSDNCYGQFRMIETPKTCHCP 1005
            +LL+A+++    L+ G C  K      CC G++ +C+  D    +  G    C+CDE CVK+KDCC DY   C  +  +C++SNW  WS C+  C   V++R R V     + G  C                                             P+LE     ++   +R  R G              PKR+ Y        C   ++ + T  C        L   Y       +  G +VC+TC   +  N    +G+  ++  +    W A  +  CYG +R I+  + C CP
Sbjct:   11 WLLLAITVGQNSLVTGGCSGK------CCWGRDLSCYTSDWRMDRSYG---TCYCDESCVKTKDCCFDYFTECPAR--DCVVSNWSPWSGCAKPCQLSVRSRVRHVKQKPSNGGEPC---------------------------------------------PRLEERAGCKEYRDHRGSRCGHPAFITSMQFGKGRPKRDSYGNPLDPGFCMELKLESRTPPCTAENRPHTLWMRY-------IAEGFKVCVTCEPPASQNRSLCQGDGQDSDKQAVLHWQAAGNPRCYGTWRKIQRMQQCDCP 252
[Close]
BLAST of SMB domain-containing protein vs. Ensembl Medaka
Match: hmcn1 (hemicentin 1 [Source:NCBI gene;Acc:101172646])

HSP 1 Score: 48.9062 bits (115), Expect = 8.849e-6
Identity = 28/81 (34.57%), Postives = 39/81 (48.15%), Query Frame = 1 
Query:  289 CDEHCVKSKDCCSDYKRLCSTKAINCILSNWGQWSPCSVDCGAGVQTRFRKVIIPQ-QHNGRTCD-HTEQARFCHNNSCSI 525
            C+    +SK C    +RLC         S+W  W PCSV CG G + R R    P  QH GR+C+ +     FC+ + C +
Sbjct: 4420 CEGTDTQSKMC---LERLCPHGK----WSSWMNWGPCSVSCGGGTRQRTRLCASPAPQHGGRSCEGNGVHMDFCNTDPCPV 4493
[Close]
BLAST of SMB domain-containing protein vs. Planmine SMEST
Match: SMESG000079236.1 (SMESG000079236.1)

HSP 1 Score: 588.956 bits (1517), Expect = 0.000e+0
Identity = 304/305 (99.67%), Postives = 304/305 (99.67%), Query Frame = 1 
Query:  118 MNWYLLIALSLPAFRLIFGSCWIKSENRLTCCQGKNHTCHGFDKIGSKWAGRQIKCFCDEHCVKSKDCCSDYKRLCSTKAINCILSNWGQWSPCSVDCGAGVQTRFRKVIIPQQHNGRTCDHTEQARFCHNNSCSILRRVAXXXXXXXXXXXXXXXXXXTEIHLIPKLERNIDTRKLISNRFGRNGKIYMADLSSRNNADPKRNVYCATYQITNSTSSCKVWKDLSKLEQIYWKSHSERLNNGQRVCLTCSSHSDNNYKCFEGNKLNNLNKWTAVRSDNCYGQFRMIETPKTCHCPNGSLSYHVV 1032
            MNWYLLIALSLPAFRLIFGSCWIKSENRLTCCQGKNHTCHGFDKIGSKWAGRQIKCFCDEHCVKSKDCCSDYKRLCSTKAINCILSNWG WSPCSVDCGAGVQTRFRKVIIPQQHNGRTCDHTEQARFCHNNSCSILRRVAKVKTKRHSKSKRRPKKLRTEIHLIPKLERNIDTRKLISNRFGRNGKIYMADLSSRNNADPKRNVYCATYQITNSTSSCKVWKDLSKLEQIYWKSHSERLNNGQRVCLTCSSHSDNNYKCFEGNKLNNLNKWTAVRSDNCYGQFRMIETPKTCHCPNGSLSYHVV
Sbjct:    1 MNWYLLIALSLPAFRLIFGSCWIKSENRLTCCQGKNHTCHGFDKIGSKWAGRQIKCFCDEHCVKSKDCCSDYKRLCSTKAINCILSNWGHWSPCSVDCGAGVQTRFRKVIIPQQHNGRTCDHTEQARFCHNNSCSILRRVAKVKTKRHSKSKRRPKKLRTEIHLIPKLERNIDTRKLISNRFGRNGKIYMADLSSRNNADPKRNVYCATYQITNSTSSCKVWKDLSKLEQIYWKSHSERLNNGQRVCLTCSSHSDNNYKCFEGNKLNNLNKWTAVRSDNCYGQFRMIETPKTCHCPNGSLSYHVV 305
[Close]
BLAST of SMB domain-containing protein vs. Planmine SMEST
Match: SMESG000022577.1 (SMESG000022577.1)

HSP 1 Score: 158.303 bits (399), Expect = 1.814e-45
Identity = 100/299 (33.44%), Postives = 150/299 (50.17%), Query Frame = 1 
Query:  154 AFRLIFGSCW--IKSEN---RLTCCQGKNHTCHGFDKIGSKWAGRQIKCFCDEHCVKSKDCCSDYKRLCST-KAINCILSNWGQWSPCSVDCGAGVQTRFRKVIIPQQHNGRTCDHTEQARFCHNNSCSILRRVAXXXXXXXXXXXXXXXXXXTEIHLIPKLERNIDTRKLISNRFGRNGKIYMADLSSRNNADPKRNVYCATYQITNSTSSCKVWKDLSKLEQIYWKSHSERLNNGQRVCLTCSSHSDNNYK-----CFEGNKLNNLNKWTAVRSDNCYGQFRMIETPKTCHCPNGSL 1017
             F LIF +    I +EN   +  CC+G+N +C   D +G+K      KC+CD  C +SKDCC D+K+ C T + +NC+LSNW  W+ C+ +CG G Q R RK+I   ++NGR CD     + CHN  C + +        R  K  +  K   +   L+P      D  K  ++++     +Y   L   N  +     YCA Y+I  +  SC  ++ L K+++  W  H   L   +++C TC  +S+N YK     C     L    +W A+RSDNC+G F++I   K C CP  S 
Sbjct:   13 TFILIFVAALLQISAENLSCQNRCCKGQNSSCVSHDSVGNK------KCYCDAFCYRSKDCCHDFKQFCRTSQKVNCVLSNWTPWTKCTRNCGQGFQFRSRKIIFHPKNNGRKCDSLRDVKTCHNVLCPVQK-----FENRKRKLTQHSKMTSSVAQLLPDSGIKADIYKHYNHKYDIRQHLYRNSLHQLNITEQSDTPYCAFYKIIFTFGSCDNFQKLKKIDRANWSQHFLFLQKDRKICATC--YSENKYKELSNQCQGTGLLYKPTRWRAIRSDNCHGYFKLIHKRKNCSCPPNSF 298
The following BLAST results are available for this feature:
BLAST of SMB domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
SBSPON2.595e-729.91somatomedin B and thrombospondin type 1 domain con... [more]
ADGRB23.576e-631.46adhesion G protein-coupled receptor B2 [Source:HGN... [more]
ADGRB23.702e-631.46adhesion G protein-coupled receptor B2 [Source:HGN... [more]
ADGRB23.946e-631.46adhesion G protein-coupled receptor B2 [Source:HGN... [more]
ADGRB23.946e-631.46adhesion G protein-coupled receptor B2 [Source:HGN... [more]
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BLAST of SMB domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
R17.31.025e-1341.03pep chromosome:WBcel235:III:10837445:10839451:1 ge... [more]
R17.32.523e-1341.03pep chromosome:WBcel235:III:10832936:10839451:1 ge... [more]
R17.32.523e-1341.03pep chromosome:WBcel235:III:10835014:10839451:1 ge... [more]
R17.32.606e-1341.03pep chromosome:WBcel235:III:10832936:10839451:1 ge... [more]
R17.32.606e-1341.03pep chromosome:WBcel235:III:10835014:10839451:1 ge... [more]
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BLAST of SMB domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
CG423396.093e-1332.43gene:FBgn0259241 transcript:FBtr0299862[more]
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BLAST of SMB domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
si:dkey-178e17.37.944e-2026.28si:dkey-178e17.3 [Source:ZFIN;Acc:ZDB-GENE-081104-... [more]
SBSPON1.177e-1424.82somatomedin B and thrombospondin type 1 domain con... [more]
si:dkey-178e17.31.486e-1124.56si:dkey-178e17.3 [Source:ZFIN;Acc:ZDB-GENE-081104-... [more]
si:dkey-7k24.56.038e-1023.43si:dkey-7k24.5 [Source:ZFIN;Acc:ZDB-GENE-131127-62... [more]
si:dkey-7k24.56.038e-1023.43si:dkey-7k24.5 [Source:ZFIN;Acc:ZDB-GENE-131127-62... [more]
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BLAST of SMB domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
fam107a2.543e-1722.26family with sequence similarity 107 member A [Sour... [more]
SBSPON1.682e-1523.57somatomedin B and thrombospondin type 1 domain con... [more]
THSD7A7.336e-649.12thrombospondin type 1 domain containing 7A [Source... [more]
THSD7A7.798e-649.12thrombospondin type 1 domain containing 7A [Source... [more]
THSD7A8.116e-649.12thrombospondin type 1 domain containing 7A [Source... [more]
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BLAST of SMB domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Sbspon9.091e-722.95somatomedin B and thrombospondin, type 1 domain co... [more]
Adgrb22.370e-631.46adhesion G protein-coupled receptor B2 [Source:MGI... [more]
Adgrb22.390e-631.46adhesion G protein-coupled receptor B2 [Source:MGI... [more]
Adgrb22.435e-631.46adhesion G protein-coupled receptor B2 [Source:MGI... [more]
Adgrb22.547e-631.46adhesion G protein-coupled receptor B2 [Source:MGI... [more]
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BLAST of SMB domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 3
Match NameE-valueIdentityDescription
sp|Q32L50|SBSPO_BOVIN3.840e-832.67Somatomedin-B and thrombospondin type-1 domain-con... [more]
sp|Q8IVN8|SBSPO_HUMAN1.246e-629.91Somatomedin-B and thrombospondin type-1 domain-con... [more]
sp|Q3UPR9|SBSPO_MOUSE6.359e-622.95Somatomedin-B and thrombospondin type-1 domain-con... [more]
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BLAST of SMB domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A0X3P2U11.208e-3028.28Somatomedin-B and thrombospondin type-1 domain-con... [more]
G4VAK54.911e-2723.58SMB domain-containing protein OS=Schistosoma manso... [more]
A0A0R3U3F29.390e-2727.60SMB domain-containing protein OS=Mesocestoides cor... [more]
A0A430QQ212.221e-2522.96SMB domain-containing protein OS=Schistosoma bovis... [more]
C1LEZ02.050e-2425.56Putative spondin 99.0 OS=Schistosoma japonicum OX=... [more]
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BLAST of SMB domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 3
Match NameE-valueIdentityDescription
si:dkey-178e17.32.601e-2326.16somatomedin-B and thrombospondin type-1 domain-con... [more]
SBSPON2.451e-1323.08somatomedin B and thrombospondin type 1 domain con... [more]
si:dkey-7k24.51.703e-1130.77somatomedin-B and thrombospondin type-1 domain-con... [more]
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BLAST of SMB domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
si:dkey-178e17.31.556e-1121.17si:dkey-178e17.3 [Source:ZFIN;Acc:ZDB-GENE-081104-... [more]
si:dkey-178e17.37.030e-940.74si:dkey-178e17.3 [Source:ZFIN;Acc:ZDB-GENE-081104-... [more]
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BLAST of SMB domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMB domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2
Match NameE-valueIdentityDescription
EDO475048.144e-2328.78Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO498951.783e-640.00Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of SMB domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 3
Match NameE-valueIdentityDescription
si:dkey-178e17.39.851e-2526.18somatomedin-B and thrombospondin type-1 domain-con... [more]
SBSPON1.660e-1723.93somatomedin B and thrombospondin type 1 domain con... [more]
hmcn18.849e-634.57hemicentin 1 [Source:NCBI gene;Acc:101172646][more]
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BLAST of SMB domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000079236.10.000e+099.67SMESG000079236.1[more]
SMESG000022577.11.814e-4533.44SMESG000022577.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30031183 ID=SMED30031183|Name=SMB domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1105bp
CTTTTTTTGCTCGATTTTGATTGGATGCCGTCAGAAGCCCATAAAACTTT
GTCACATCTCAATTATTTTTTGTTTGAATTTGAACTGAGAAAACAAAATC
CAAATGATAATTGAATAATGAATTGGTATTTGTTGATTGCGTTGAGCTTA
CCAGCTTTCCGGTTAATTTTCGGGTCTTGTTGGATTAAATCGGAAAATCG
GTTGACTTGCTGCCAGGGCAAAAATCACACTTGTCACGGATTTGATAAAA
TCGGTTCCAAATGGGCTGGTAGACAAATTAAATGCTTTTGCGACGAACAC
TGCGTCAAGTCCAAGGATTGTTGTTCTGATTACAAAAGGCTTTGCAGCAC
GAAAGCAATAAATTGCATATTGTCAAATTGGGGTCAGTGGTCTCCCTGCT
CCGTTGATTGTGGTGCTGGAGTTCAAACGCGTTTCCGCAAGGTCATTATC
CCTCAACAACATAACGGAAGGACGTGTGACCATACAGAGCAAGCGAGATT
CTGTCACAATAATTCGTGTTCTATACTTAGACGAGTCGCAAAAGTGAAAA
CCAAGCGCCATAGCAAATCAAAAAGACGGCCAAAAAAACTTCGAACTGAG
ATTCATTTGATTCCGAAATTAGAACGTAACATTGACACGAGAAAGTTGAT
AAGCAACCGATTTGGGAGAAATGGAAAGATTTATATGGCAGATTTATCAA
GCAGAAATAATGCAGATCCCAAAAGAAATGTGTACTGTGCCACATATCAA
ATTACGAATTCGACCTCAAGCTGTAAAGTTTGGAAAGATTTATCCAAGTT
GGAGCAAATATATTGGAAAAGTCATAGTGAAAGACTAAATAATGGGCAAA
GGGTTTGTCTTACCTGTTCTAGCCATTCGGATAATAATTACAAATGTTTC
GAAGGAAATAAATTGAACAACTTAAATAAATGGACGGCAGTTCGAAGCGA
TAATTGCTATGGACAGTTTAGGATGATTGAAACACCAAAGACATGTCACT
GTCCAAATGGGTCTCTGTCATACCACGTTGTCTAAAAATTTTATTTGTTT
ATTGAGCGTTCTCATTGTAACAATATTTGTAACATTTATTCAGTTGGTTT
GCTCA
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protein sequence of SMED30031183-orf-1

>SMED30031183-orf-1 ID=SMED30031183-orf-1|Name=SMED30031183-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=306bp
MNWYLLIALSLPAFRLIFGSCWIKSENRLTCCQGKNHTCHGFDKIGSKWA
GRQIKCFCDEHCVKSKDCCSDYKRLCSTKAINCILSNWGQWSPCSVDCGA
GVQTRFRKVIIPQQHNGRTCDHTEQARFCHNNSCSILRRVAKVKTKRHSK
SKRRPKKLRTEIHLIPKLERNIDTRKLISNRFGRNGKIYMADLSSRNNAD
PKRNVYCATYQITNSTSSCKVWKDLSKLEQIYWKSHSERLNNGQRVCLTC
SSHSDNNYKCFEGNKLNNLNKWTAVRSDNCYGQFRMIETPKTCHCPNGSL
SYHVV*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: cellular component
TermDefinition
GO:0016020membrane
GO:0016021integral component of membrane
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000025nervous system
PLANA:0000099neuron
PLANA:0000101muscle cell
PLANA:0000418head
Vocabulary: INTERPRO
TermDefinition
IPR036383TSP1_rpt_sf
IPR039942SBSPON
IPR036024Somatomedin_B-like_dom_sf
IPR000884TSP1_rpt
IPR001212Somatomedin_B_dom
Vocabulary: molecular function
TermDefinition
GO:0005044scavenger receptor activity
GO:0030247polysaccharide binding
Vocabulary: biological process
TermDefinition
GO:0006955immune response
GO:0006898receptor-mediated endocytosis
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000884Thrombospondin type-1 (TSP1) repeatSMARTSM00209TSP1_2coord: 85..135
e-value: 2.3E-12
score: 57.1
IPR000884Thrombospondin type-1 (TSP1) repeatPFAMPF00090TSP_1coord: 86..134
e-value: 2.6E-10
score: 40.3
IPR000884Thrombospondin type-1 (TSP1) repeatPROSITEPS50092TSP1coord: 82..135
score: 11.662
IPR001212Somatomedin B domainPFAMPF01033Somatomedin_Bcoord: 31..78
e-value: 2.3E-5
score: 24.7
IPR001212Somatomedin B domainPROSITEPS00524SMB_1coord: 56..76
IPR001212Somatomedin B domainPROSITEPS50958SMB_2coord: 35..80
score: 6.795
IPR036383Thrombospondin type-1 (TSP1) repeat superfamilyGENE3DG3DSA:2.20.100.10coord: 81..129
e-value: 2.1E-14
score: 55.6
IPR036383Thrombospondin type-1 (TSP1) repeat superfamilySUPERFAMILYSSF82895TSP-1 type 1 repeatcoord: 81..130
IPR039942Somatomedin-B and thrombospondin type-1 domain-containing proteinPANTHERPTHR20920RPE-SPONDINcoord: 21..297
NoneNo IPR availableSIGNALP_EUKSignalP-noTMSignalP-noTMcoord: 1..19
score: 0.761
IPR036024Somatomedin B-like domain superfamilySUPERFAMILYSSF90188Somatomedin B domaincoord: 52..79