FMRFamide-activated amiloride-sensitive sodium channel
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny AppSub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30031176 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 3
Homology
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Human
Match: SCNN1A (sodium channel epithelial 1 alpha subunit [Source:HGNC Symbol;Acc:HGNC:10599]) HSP 1 Score: 61.2326 bits (147), Expect = 4.291e-9 Identity = 81/350 (23.14%), Postives = 129/350 (36.86%), Query Frame = 2 Query: 614 QDSISQLKISLFSHQDFFNCYTIEGEQE---YTKSIVGLIFILDIVPSDEIYELSKSFLIDMLNRGDGMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNCHDNQP-----NLYDLGRSFKYTHKHCMENQFQTEVINKCQCMLSNHPRPFLPNSSFPYCLKLNYTNNSEILDKRFSCVEKVQEHFSLNREIIENQFCSLRCRYSTYETTMSLTQWKASEQKLEHLQKLYRSYFSLKQKQSKENINNVINILKSSLKDTKDFRENLRKFHKLNKSLVRNKINDLTYVSITRKNFEISIKKEKLVLDSNTLLSRMGGLSSLCIGLTAAFVAEIIEFIY 1639 Q S +Q S F H + NCYT + + S+ G+ L ++ E ++ I +L+ G ++++H +D+ GFNL P SI + RL +C N NLY KYT + C+ + FQ +I +C C +PRP + YC +Y +S C K+Q FS + + C C ++Y+ + ++W + + Q L R N V NK N + V+I K E + TLLS +G SL G + V E+ E ++ Sbjct: 286 QVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAE-----QNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPS----KYTQQVCIHSCFQESMIKECGCAYIFYPRP----QNVEYC---DYRKHSSW----GYCYYKLQVDFSSDHLGCFTK-CRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQ----------------------------------------NNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVF 574
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Human
Match: SCNN1A (sodium channel epithelial 1 alpha subunit [Source:HGNC Symbol;Acc:HGNC:10599]) HSP 1 Score: 60.8474 bits (146), Expect = 5.515e-9 Identity = 81/350 (23.14%), Postives = 129/350 (36.86%), Query Frame = 2 Query: 614 QDSISQLKISLFSHQDFFNCYTIEGEQE---YTKSIVGLIFILDIVPSDEIYELSKSFLIDMLNRGDGMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNCHDNQP-----NLYDLGRSFKYTHKHCMENQFQTEVINKCQCMLSNHPRPFLPNSSFPYCLKLNYTNNSEILDKRFSCVEKVQEHFSLNREIIENQFCSLRCRYSTYETTMSLTQWKASEQKLEHLQKLYRSYFSLKQKQSKENINNVINILKSSLKDTKDFRENLRKFHKLNKSLVRNKINDLTYVSITRKNFEISIKKEKLVLDSNTLLSRMGGLSSLCIGLTAAFVAEIIEFIY 1639 Q S +Q S F H + NCYT + + S+ G+ L ++ E ++ I +L+ G ++++H +D+ GFNL P SI + RL +C N NLY KYT + C+ + FQ +I +C C +PRP + YC +Y +S C K+Q FS + + C C ++Y+ + ++W + + Q L R N V NK N + V+I K E + TLLS +G SL G + V E+ E ++ Sbjct: 309 QVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAE-----QNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPS----KYTQQVCIHSCFQESMIKECGCAYIFYPRP----QNVEYC---DYRKHSSW----GYCYYKLQVDFSSDHLGCFTK-CRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQ----------------------------------------NNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVF 597
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Human
Match: SCNN1A (sodium channel epithelial 1 alpha subunit [Source:HGNC Symbol;Acc:HGNC:10599]) HSP 1 Score: 60.077 bits (144), Expect = 8.481e-9 Identity = 81/350 (23.14%), Postives = 129/350 (36.86%), Query Frame = 2 Query: 614 QDSISQLKISLFSHQDFFNCYTIEGEQE---YTKSIVGLIFILDIVPSDEIYELSKSFLIDMLNRGDGMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNCHDNQP-----NLYDLGRSFKYTHKHCMENQFQTEVINKCQCMLSNHPRPFLPNSSFPYCLKLNYTNNSEILDKRFSCVEKVQEHFSLNREIIENQFCSLRCRYSTYETTMSLTQWKASEQKLEHLQKLYRSYFSLKQKQSKENINNVINILKSSLKDTKDFRENLRKFHKLNKSLVRNKINDLTYVSITRKNFEISIKKEKLVLDSNTLLSRMGGLSSLCIGLTAAFVAEIIEFIY 1639 Q S +Q S F H + NCYT + + S+ G+ L ++ E ++ I +L+ G ++++H +D+ GFNL P SI + RL +C N NLY KYT + C+ + FQ +I +C C +PRP + YC +Y +S C K+Q FS + + C C ++Y+ + ++W + + Q L R N V NK N + V+I K E + TLLS +G SL G + V E+ E ++ Sbjct: 345 QVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAE-----QNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLY----PSKYTQQVCIHSCFQESMIKECGCAYIFYPRP----QNVEYC---DYRKHSSW----GYCYYKLQVDFSSDHLGCFTK-CRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQ----------------------------------------NNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVF 633
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Human
Match: SCNN1G (sodium channel epithelial 1 gamma subunit [Source:HGNC Symbol;Acc:HGNC:10602]) HSP 1 Score: 58.9214 bits (141), Expect = 1.866e-8 Identity = 55/225 (24.44%), Postives = 95/225 (42.22%), Query Frame = 2 Query: 641 SLFSHQDFFNCYTI---EGEQEYTKSIVGLIFILDIVPSDEIY---ELSKSFLIDMLNRGDGMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNCHDNQP-----NLYDLGRSFKYTHKHCMENQFQTEVINKCQCMLSNHPRPFLPNSSFPYCLKLNYTNNSEILDKRFSCVEKVQEHFSLNREIIENQFCSLRCRYSTYETTMSLTQWKA 1282 +LF H NCYT E E + S+ G + L ++ +Y E FL+ G K++IH P +++ G + + + SI T+ ++L P C ++ N+Y+ Y+ + C+ + FQT+++ KC C + P P N YC NY + + C ++ F + E+ C C + + T SL QW + Sbjct: 273 TLFHHPMHGNCYTFNNRENETILSTSMGGSEYGLQVI----LYINEEEYNPFLVS----STGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESFKLSEPYSQCTEDGSDVPIRNIYNAA----YSLQICLHSCFQTKMVEKCGCAQYSQPLPPAAN----YC---NYQQHPNWM----YCYYQLHRAF-VQEELGCQSVCKEACSFKEWTLTTSLAQWPS 473
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Human
Match: SCNN1D (sodium channel epithelial 1 delta subunit [Source:HGNC Symbol;Acc:HGNC:10601]) HSP 1 Score: 56.6102 bits (135), Expect = 9.464e-8 Identity = 50/250 (20.00%), Postives = 106/250 (42.40%), Query Frame = 2 Query: 647 FSHQDFFNCYTIEG----EQEYTKSIVGLIFILDIVPSDEIYELSKSFLIDMLNRGDGMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNCHDNQPNL-YDLGRSFKYTHKHCMENQFQTEVINKCQCMLSNHPRPFLPNSSFPYCLKLNYTNNSEILDKRFSCVEKVQEHFSLNREIIENQFCSLRCRYSTYETTMSLTQW---KASEQKLEHLQKLYRSYFSLKQKQSKENINNV 1372 F H + +CYT++G ++ VGL+ ++ P + +L+ G+++++H ++ P + + F++ P +I + + +RL +P +C + +L + YT + C+ + FQ ++ C C HP P + YC + C ++ + +R ++ C CR S ++ + ++W K++ L L + + S +Q+ S IN V Sbjct: 278 FHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQPH-----------LPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLP----AGAEYCSSARHPAWGH-------CFYRLYQDLETHRLPCTSR-CPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIV 504
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Celegans
Match: asic-2 (Degenerin-like protein asic-2 [Source:UniProtKB/Swiss-Prot;Acc:Q22851]) HSP 1 Score: 55.0694 bits (131), Expect = 1.146e-7 Identity = 40/164 (24.39%), Postives = 74/164 (45.12%), Query Frame = 2 Query: 806 GMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNCHDNQPNLYDLGRSFKYTHKHCMENQFQTEVINKCQCMLSNHPRPFLPNSSFPYCLKLNYTNNS-EILDKRFSCVEKV---QEHFSLNREIIENQFCSLRCRYSTYETTMSLTQWKAS 1285 G +I ++ + P +D++G + +++ S T R + P C D +P+ D + F YT + C Q + I KCQC +PR L L T+ + + + C++ + Q + N +++ C+ C STY T+SL Q+ ++ Sbjct: 238 GARIGVNSRGSSPGLDSNGIDAGVGYESAVSVSLTQNVRAKKPYGTCVDREPDSSDYYKDFIYTLETCFNGCKQRDTIAKCQCA---NPR-----------LALGSTDTACQPIKADLDCLQTLKGNQTSSTPNIDLLVECNCNPPCDESTYTPTVSLAQFPST 387
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Celegans
Match: unc-105 (Degenerin-like protein unc-105 [Source:UniProtKB/Swiss-Prot;Acc:Q09274]) HSP 1 Score: 53.1434 bits (126), Expect = 4.787e-7 Identity = 59/283 (20.85%), Postives = 112/283 (39.58%), Query Frame = 2 Query: 806 GMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNC-HDNQPNLYDLGRSFKYTHKHCMENQFQTEVINKCQCMLSNHPRPFLPNSSFPYCLKLNYTNNSEILDKRFSCVEK----VQEHFSLNRE-IIENQFCSLRCRYSTYETTMSLTQWKASEQKLEHLQKLYRSYFSLKQKQSKENINNVINILKSSLKDTKDFRENLRKFHKLNKSLVRNKINDLTYVSITRKNFEISIKKEKLVLDSNTLLSRMGGLSSLCIGLTAAFVAEIIEFI 1636 G +I +H+ H +P D G++ M+S + RL P +C H + + F+Y+ + C + Q ++ C C +P + ++ C +N +D+R C+ + E +S +E II + +C C+ + YE T S +W + K+ ++ L + L E RK N ++V+ +L Y ++ +E ++L+ +GGL+ L IG + + EI+ I Sbjct: 427 GFRITVHDKHIVPFPDAFGYSAPTGFMSSFGVRMKQFIRLEPPYGHCRHGGEDAATFVYTGFQYSVEACHRSCAQKVIVEACGCADPMYPVAEMFGNNTKPCQAVN-------MDQR-ECLRNTTLWLGELYSKGKEAIIPDCYCHQPCQETNYEVTYSSARWPSGSAKV--MECLPGDFLCL---------------------------EKYRK----NAAMVQIFYEELNYETM----------QESPAYTLTSVLADLGGLTGLWIGASVVSLLEIVTLI 658
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Celegans
Match: unc-105 (Degenerin-like protein unc-105 [Source:UniProtKB/Swiss-Prot;Acc:Q09274]) HSP 1 Score: 53.1434 bits (126), Expect = 4.787e-7 Identity = 59/283 (20.85%), Postives = 112/283 (39.58%), Query Frame = 2 Query: 806 GMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNC-HDNQPNLYDLGRSFKYTHKHCMENQFQTEVINKCQCMLSNHPRPFLPNSSFPYCLKLNYTNNSEILDKRFSCVEK----VQEHFSLNRE-IIENQFCSLRCRYSTYETTMSLTQWKASEQKLEHLQKLYRSYFSLKQKQSKENINNVINILKSSLKDTKDFRENLRKFHKLNKSLVRNKINDLTYVSITRKNFEISIKKEKLVLDSNTLLSRMGGLSSLCIGLTAAFVAEIIEFI 1636 G +I +H+ H +P D G++ M+S + RL P +C H + + F+Y+ + C + Q ++ C C +P + ++ C +N +D+R C+ + E +S +E II + +C C+ + YE T S +W + K+ ++ L + L E RK N ++V+ +L Y ++ +E ++L+ +GGL+ L IG + + EI+ I Sbjct: 427 GFRITVHDKHIVPFPDAFGYSAPTGFMSSFGVRMKQFIRLEPPYGHCRHGGEDAATFVYTGFQYSVEACHRSCAQKVIVEACGCADPMYPVAEMFGNNTKPCQAVN-------MDQR-ECLRNTTLWLGELYSKGKEAIIPDCYCHQPCQETNYEVTYSSARWPSGSAKV--MECLPGDFLCL---------------------------EKYRK----NAAMVQIFYEELNYETM----------QESPAYTLTSVLADLGGLTGLWIGASVVSLLEIVTLI 658
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Celegans
Match: unc-105 (Degenerin-like protein unc-105 [Source:UniProtKB/Swiss-Prot;Acc:Q09274]) HSP 1 Score: 53.1434 bits (126), Expect = 5.121e-7 Identity = 59/283 (20.85%), Postives = 112/283 (39.58%), Query Frame = 2 Query: 806 GMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNC-HDNQPNLYDLGRSFKYTHKHCMENQFQTEVINKCQCMLSNHPRPFLPNSSFPYCLKLNYTNNSEILDKRFSCVEK----VQEHFSLNRE-IIENQFCSLRCRYSTYETTMSLTQWKASEQKLEHLQKLYRSYFSLKQKQSKENINNVINILKSSLKDTKDFRENLRKFHKLNKSLVRNKINDLTYVSITRKNFEISIKKEKLVLDSNTLLSRMGGLSSLCIGLTAAFVAEIIEFI 1636 G +I +H+ H +P D G++ M+S + RL P +C H + + F+Y+ + C + Q ++ C C +P + ++ C +N +D+R C+ + E +S +E II + +C C+ + YE T S +W + K+ ++ L + L E RK N ++V+ +L Y ++ +E ++L+ +GGL+ L IG + + EI+ I Sbjct: 447 GFRITVHDKHIVPFPDAFGYSAPTGFMSSFGVRMKQFIRLEPPYGHCRHGGEDAATFVYTGFQYSVEACHRSCAQKVIVEACGCADPMYPVAEMFGNNTKPCQAVN-------MDQR-ECLRNTTLWLGELYSKGKEAIIPDCYCHQPCQETNYEVTYSSARWPSGSAKV--MECLPGDFLCL---------------------------EKYRK----NAAMVQIFYEELNYETM----------QESPAYTLTSVLADLGGLTGLWIGASVVSLLEIVTLI 678
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Celegans
Match: unc-105 (Degenerin-like protein unc-105 [Source:UniProtKB/Swiss-Prot;Acc:Q09274]) HSP 1 Score: 53.1434 bits (126), Expect = 5.121e-7 Identity = 59/283 (20.85%), Postives = 112/283 (39.58%), Query Frame = 2 Query: 806 GMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNC-HDNQPNLYDLGRSFKYTHKHCMENQFQTEVINKCQCMLSNHPRPFLPNSSFPYCLKLNYTNNSEILDKRFSCVEK----VQEHFSLNRE-IIENQFCSLRCRYSTYETTMSLTQWKASEQKLEHLQKLYRSYFSLKQKQSKENINNVINILKSSLKDTKDFRENLRKFHKLNKSLVRNKINDLTYVSITRKNFEISIKKEKLVLDSNTLLSRMGGLSSLCIGLTAAFVAEIIEFI 1636 G +I +H+ H +P D G++ M+S + RL P +C H + + F+Y+ + C + Q ++ C C +P + ++ C +N +D+R C+ + E +S +E II + +C C+ + YE T S +W + K+ ++ L + L E RK N ++V+ +L Y ++ +E ++L+ +GGL+ L IG + + EI+ I Sbjct: 447 GFRITVHDKHIVPFPDAFGYSAPTGFMSSFGVRMKQFIRLEPPYGHCRHGGEDAATFVYTGFQYSVEACHRSCAQKVIVEACGCADPMYPVAEMFGNNTKPCQAVN-------MDQR-ECLRNTTLWLGELYSKGKEAIIPDCYCHQPCQETNYEVTYSSARWPSGSAKV--MECLPGDFLCL---------------------------EKYRK----NAAMVQIFYEELNYETM----------QESPAYTLTSVLADLGGLTGLWIGASVVSLLEIVTLI 678
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Xenopus
Match: copg2 (coatomer protein complex subunit gamma 2 [Source:Xenbase;Acc:XB-GENE-941264]) HSP 1 Score: 75.485 bits (184), Expect = 1.242e-13 Identity = 79/337 (23.44%), Postives = 130/337 (38.58%), Query Frame = 2 Query: 647 FSHQDFFNCYTIEG---EQEYTKSIVGLIFILDIVPSDEIYELSKSFLIDMLNRGDGMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNCHDNQPNLYDLGRSF----KYTHKHCMENQFQTEVINKCQCMLSNHPRPFLPNSSFPYCLKLNYTNNSEILDKRFSCVEKVQEHFSLNREIIENQFCSLRCRYSTYETTMSLTQWKASEQKLEHLQKLYRSYFSLKQKQSKENINNVINILKSSLKDTKDFRENLRKFHKLNKSLVRNKINDLTYVSITRKNFEISIKKEKLVLDSNTLLSRMGGLSSLCIGLTAAFVAEIIEFI 1636 F H + NC+TI E + S G + L IV ++++ + +L++ G +I+IH P+ P +++ GF++ P NSI Q + RL C + DLG YT + C+ + FQ ++I C C +P P YC NY + + + EK+ +H +I C +C+ + Y + +W + K + L L Y S + R ++ K + + L + + VS+T LLS MGGL S G + VAEI E + Sbjct: 256 FHHPIYGNCFTINNHWKENSWYSSRPGKQYGLSIVVKTDLHDN-----MPLLSQAAGARIMIHNPNQPPLVEHQGFDIRPGTENSISVKQEEAIRLGGKYSQCTSDGS---DLGIKILYNTSYTMQACLNSCFQYKMIEVCGCGYYFYPLP----PGMEYC---NYNKHPDWGYCFYQLYEKMLDH-----TLICFTQCPKQCKQTEYHLSAGTAKWPSPVSKAKKLLSLQERYNSTSK------------------------RSDISKINVYYEELSYRSVEETPSVSVT------------------MLLSSMGGLWSWWFGSSVLSVAEIAELV 530
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Xenopus
Match: copg2 (coatomer protein complex subunit gamma 2 [Source:Xenbase;Acc:XB-GENE-941264]) HSP 1 Score: 70.8626 bits (172), Expect = 2.971e-12 Identity = 78/337 (23.15%), Postives = 133/337 (39.47%), Query Frame = 2 Query: 647 FSHQDFFNCYTIEG---EQEYTKSIVGLIFILDIVPSDEIYELSKSFLIDMLNRGDGMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNCHDNQPNLYDLGRSF----KYTHKHCMENQFQTEVINKCQCMLSNHPRPFLPNSSFPYCLKLNYTNNSEILDKRFSCVEKVQEHFSLNREIIENQFCSLRCRYSTYETTMSLTQWKASEQKLEHLQKLYRSYFSLKQKQSKENINNVINILKSSLKDTKDFRENLRKFHKLNKSLVRNKINDLTYVSITRKNFEISIKKEKLVLDSNTLLSRMGGLSSLCIGLTAAFVAEIIEFI 1636 F H + NC+TI E + S G + L IV ++++ + +L++ G +I+IH P+ P +++ GF++ P NSI Q + RL C + DLG YT + C+ + FQ ++I C C +P P YC NY + + + EK+ +H +I C +C+ + Y + +W + + K+ Y ++K K + + + D + K + + L + + VS+T LLS MGGL S G + VAEI E + Sbjct: 256 FHHPIYGNCFTINNHWKENSWYSSRPGKQYGLSIVVKTDLHDN-----MPLLSQAAGARIMIHNPNQPPLVEHQGFDIRPGTENSISVKQEEAIRLGGKYSQCTSDGS---DLGIKILYNTSYTMQACLNSCFQYKMIEVCGCGYYFYPLP----PGMEYC---NYNKHPDWGYCFYQLYEKMLDH-----TLICFTQCPKQCKQTEYHLSAGTAKWPSP------VSKVSNDYITIKAK------------VYWGVWELSD----ISKINVYYEELSYRSVEETPSVSVT------------------MLLSSMGGLWSWWFGSSVLSVAEIAELV 532
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Xenopus
Match: cdh12 (cadherin 12, type 2 (N-cadherin 2) [Source:Xenbase;Acc:XB-GENE-982876]) HSP 1 Score: 62.7734 bits (151), Expect = 1.088e-9 Identity = 84/341 (24.63%), Postives = 134/341 (39.30%), Query Frame = 2 Query: 641 SLFSHQDFFNCYTIEGEQE---YTKSIVGLIFILDIVPSDEIYELSKSFLIDMLNRGDGMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNCHDNQP-----NLYDLGRSFKYTHKHCMENQFQTEVINKCQCMLSNHPRPFLPNSSFPYCLKLNYTNNSEILDKRFSCVEKVQEHFSLNREIIENQFCSLRCRYSTYETTMSLTQWKASEQKLEHLQKLYRSYFSLKQKQSKENINNVINILKSSLKDTKDFRENLRKFHKLNKSLVRNKINDLTYVSITRKNFEISIKKEKLVLDSNTLLSRMGGLSSLCIGLTAAFVAEIIEFIY 1639 +LF H + NCYT + S+ G + L +V +Y + + L+ G KI++H+ P I++ G L + SI T+ +L P +C + NLY S KYT + C+ + FQ E++ C C + P LPN + YC N E C K+ + F + E+ C C + + T SL +W SL +Q ++ +L L + KLNK+L + NDL ++I ++ E + TLLS GG L + + V EI+E + Sbjct: 284 TLFHHPLYGNCYTFNSAERGNLLVSSMGGAEYGLKVV----LY-IDEDEYNPYLSTAAGAKILVHDQDEYPFIEDLGTELETATETSIGMQLTESTKLSDPYSDCTMDGSDVSVENLY----SKKYTLQICLNSCFQREMVRTCGCAHYDQP---LPNGA-KYC-------NYEEYPSWIYCYFKLYKQF-VQEELGCQSACRESCSFKEWTLTRSLAKWP-----------------SLNSEQW------MLRVLSWELGE------------KLNKNLTK---NDLANLNIFYQDLNSRSISESPTYNIVTLLSNFGGQLGLWMSCSMICVLEIVEVFF 565
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Xenopus
Match: foxe3 (forkhead box E3 [Source:Xenbase;Acc:XB-GENE-480592]) HSP 1 Score: 62.3882 bits (150), Expect = 1.329e-9 Identity = 67/287 (23.34%), Postives = 113/287 (39.37%), Query Frame = 2 Query: 782 IDMLNRGDGMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNCHDNQPNL-YDLGRSFKYTHKHCMENQFQTEVINKCQCMLSNHPRPFLPNSSFPYCLKLNYTNNSEILDKRFSCVEKVQEHFSLNREIIENQFCSLRCRYSTYETTMSLTQWKASEQKLEHLQKLYRSYFSLKQKQSKENINNVINILKSSLKDTKDFRENLRKFHKLNKSLVRNKINDLTYVSITRKNFEISIKKEKLVLDSNTLLSRMGGLSSLCIGLTAAFVAEIIEFIY 1639 + +L++ G +I+IH P+ P +++ GF++ P SI Q + L C + NL L S YT + C+ + FQ ++ C C +P P P + YC NY + + EK+ +H R Q C ++C + Y+ + QW + K+ F L + + K + N FR ++ K + +L+Y S+ +E + LLS MGG S G + V EI E ++ Sbjct: 299 MPLLSQAAGARIMIHNPNQPPRVEHQGFDIRPGTETSIGVKQDEVRHLGGKYGPCASDGNNLGLKLLYSTSYTLQACLNSCFQYKMTETCGCGYYFYPLP--PGTE--YC---NYNKHPGWGHCFYQLYEKMLDH----RHHCFTQ-CPMQCTKTRYQLSAGTAQWPSPTSKV--------CAFLLLELECKVTLFN--------------FRSDILK--------INVYYEELSYQSV----------EETPAMPVTLLLSNMGGQWSWWFGSSVLSVVEIAELVF 533
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Xenopus
Match: cdh12 (cadherin 12, type 2 (N-cadherin 2) [Source:Xenbase;Acc:XB-GENE-982876]) HSP 1 Score: 56.9954 bits (136), Expect = 6.477e-8 Identity = 58/222 (26.13%), Postives = 93/222 (41.89%), Query Frame = 2 Query: 641 SLFSHQDFFNCYTIEGEQE---YTKSIVGLIFILDIVPSDEIYELSKSFLIDMLNRGDGMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNCHDNQP-----NLYDLGRSFKYTHKHCMENQFQTEVINKCQCMLSNHPRPFLPNSSFPYCLKLNYTNNSEILDKRFSCVEKVQEHFSLNREIIENQFCSLRCRYSTYETTMSLTQWKA 1282 +LF H + NCYT + S+ G + L +V +Y + + L+ G KI++H+ P I++ G L + SI T+ +L P +C + NLY S KYT + C+ + FQ E++ C C + P LPN + YC N E C K+ + F + E+ C C + + T SL +W + Sbjct: 274 TLFHHPLYGNCYTFNSAERGNLLVSSMGGAEYGLKVV----LY-IDEDEYNPYLSTAAGAKILVHDQDEYPFIEDLGTELETATETSIGMQLTESTKLSDPYSDCTMDGSDVSVENLY----SKKYTLQICLNSCFQREMVRTCGCAHYDQP---LPNGA-KYC-------NYEEYPSWIYCYFKLYKQF-VQEELGCQSACRESCSFKEWTLTRSLAKWPS 474
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Mouse
Match: Scnn1g (sodium channel, nonvoltage-gated 1 gamma [Source:MGI Symbol;Acc:MGI:104695]) HSP 1 Score: 60.8474 bits (146), Expect = 3.521e-9 Identity = 85/347 (24.50%), Postives = 137/347 (39.48%), Query Frame = 2 Query: 641 SLFSHQDFFNCYTIEGEQEYT-------KSIVGLIFILDIVPSDEIYELSKSFLIDMLNRGDGMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNCHDNQP-----NLYDLGRSFKYTHKHCMENQFQTEVINKCQCMLSNHPRPFLPNSSFPYCLKLNYTNNSEILDKRFSCVEKVQEHFSLNREIIENQFCSLRCRYSTYETTMSLTQW--KASEQKLEHLQKLYRSYFSLKQKQSKENINNVINILKSSLKDTKDFRENLRKFHKLNKSLVRNKINDLTYVSITRKNFEISIKKEKLVLDSNTLLSRMGGLSSLCIGLTAAFVAEIIEFIY 1639 +LF H + NCYT + T S GL IL I +++ Y FL+ G K+++H+ + P I++ G + + SI T+ ++L P C ++ N+Y+ Y+ + C+ + FQT+++ KC C + P P N YC NY + + C ++ + F + E+ C C + + T SL QW +ASE+ L +N+L T D + + K KLNK+ DL + I K+ E LLS GG L + + V EIIE + Sbjct: 279 TLFHHPMYGNCYTFNNRENATILSTSMGGSEYGLQVILYI--NEDEY---NPFLVS----STGAKVLVHQQNEYPFIEDVGTEIETAMSTSIGMHLTESFKLSEPYSQCTEDGSDVPVTNIYNAA----YSLQICLYSCFQTKMVEKCGCAQYSQPLPPAAN----YC---NYQQHPNWM----YCYYQLYQAF-VREELGCQSVCKQSCSFKEWTLTTSLAQWPSEASEKWL-------------------------LNVL------TWDQSQQINK--KLNKT-------DLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFF 560
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Mouse
Match: Scnn1a (sodium channel, nonvoltage-gated 1 alpha [Source:MGI Symbol;Acc:MGI:101782]) HSP 1 Score: 55.4546 bits (132), Expect = 1.709e-7 Identity = 83/357 (23.25%), Postives = 135/357 (37.82%), Query Frame = 2 Query: 614 QDSISQLKISLFSHQDFFNCYTIEGEQE---YTKSIVGLIFILDIVPSDEIYELSKSFLIDMLNRGDGMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNCHDNQP-----NLYDLGRSFKYTHKHCMENQFQTEVINKCQCMLSNHPRP-------FLPNSSFPYCLKLNYTNNSEILDKRFSCVEKVQEHFSLNREIIENQFCSLRCRYSTYETTMSLTQWKASEQKLEHLQKLYRSYFSLKQKQSKENINNVINILKSSLKDTKDFRENLRKFHKLNKSLVRNKINDLTYVSITRKNFEISIKKEKLVLDSNTLLSRMGGLSSLCIGLTAAFVAEIIEFIY 1639 Q +Q S F H + NCYT + + S+ G+ L + E ++ I +L+ G ++++H +D+ GFN+ P SI + L +C +N NLY KYT + C+ + FQ +I KC C +P+P +L SS+ YC K+Q FSL+ SL C +S S+T +K L Y + S+K S++ I ++++ N + NK N + ++I K E + +LLS +G SL G + V E+ E I+ Sbjct: 288 QAPCNQANYSQFHHPMYGNCYTFNNKNNSNLWMSSMPGVNNGLSLTLRTE-----QNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNVRPGVETSISMRKEALDSLGGNYGDCTENGSDVPVKNLYPS----KYTQQVCIHSCFQENMIKKCGCAYIFYPKPKGVEFCDYLKQSSWGYCYY------------------KLQAAFSLD---------SLGC-FSKCRKPCSVTNYK--------LSAGYSRWPSVK---SQDWIFEMLSL--------------------QNNYTINNKRNGVAKLNIFFKELNYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSVVEMAELIF 576
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Mouse
Match: Scnn1a (sodium channel, nonvoltage-gated 1 alpha [Source:MGI Symbol;Acc:MGI:101782]) HSP 1 Score: 55.4546 bits (132), Expect = 1.709e-7 Identity = 83/357 (23.25%), Postives = 135/357 (37.82%), Query Frame = 2 Query: 614 QDSISQLKISLFSHQDFFNCYTIEGEQE---YTKSIVGLIFILDIVPSDEIYELSKSFLIDMLNRGDGMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNCHDNQP-----NLYDLGRSFKYTHKHCMENQFQTEVINKCQCMLSNHPRP-------FLPNSSFPYCLKLNYTNNSEILDKRFSCVEKVQEHFSLNREIIENQFCSLRCRYSTYETTMSLTQWKASEQKLEHLQKLYRSYFSLKQKQSKENINNVINILKSSLKDTKDFRENLRKFHKLNKSLVRNKINDLTYVSITRKNFEISIKKEKLVLDSNTLLSRMGGLSSLCIGLTAAFVAEIIEFIY 1639 Q +Q S F H + NCYT + + S+ G+ L + E ++ I +L+ G ++++H +D+ GFN+ P SI + L +C +N NLY KYT + C+ + FQ +I KC C +P+P +L SS+ YC K+Q FSL+ SL C +S S+T +K L Y + S+K S++ I ++++ N + NK N + ++I K E + +LLS +G SL G + V E+ E I+ Sbjct: 288 QAPCNQANYSQFHHPMYGNCYTFNNKNNSNLWMSSMPGVNNGLSLTLRTE-----QNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNVRPGVETSISMRKEALDSLGGNYGDCTENGSDVPVKNLYPS----KYTQQVCIHSCFQENMIKKCGCAYIFYPKPKGVEFCDYLKQSSWGYCYY------------------KLQAAFSLD---------SLGC-FSKCRKPCSVTNYK--------LSAGYSRWPSVK---SQDWIFEMLSL--------------------QNNYTINNKRNGVAKLNIFFKELNYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSVVEMAELIF 576
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Mouse
Match: Scnn1a (sodium channel, nonvoltage-gated 1 alpha [Source:MGI Symbol;Acc:MGI:101782]) HSP 1 Score: 55.0694 bits (131), Expect = 1.853e-7 Identity = 83/357 (23.25%), Postives = 135/357 (37.82%), Query Frame = 2 Query: 614 QDSISQLKISLFSHQDFFNCYTIEGEQE---YTKSIVGLIFILDIVPSDEIYELSKSFLIDMLNRGDGMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNCHDNQP-----NLYDLGRSFKYTHKHCMENQFQTEVINKCQCMLSNHPRP-------FLPNSSFPYCLKLNYTNNSEILDKRFSCVEKVQEHFSLNREIIENQFCSLRCRYSTYETTMSLTQWKASEQKLEHLQKLYRSYFSLKQKQSKENINNVINILKSSLKDTKDFRENLRKFHKLNKSLVRNKINDLTYVSITRKNFEISIKKEKLVLDSNTLLSRMGGLSSLCIGLTAAFVAEIIEFIY 1639 Q +Q S F H + NCYT + + S+ G+ L + E ++ I +L+ G ++++H +D+ GFN+ P SI + L +C +N NLY KYT + C+ + FQ +I KC C +P+P +L SS+ YC K+Q FSL+ SL C +S S+T +K L Y + S+K S++ I ++++ N + NK N + ++I K E + +LLS +G SL G + V E+ E I+ Sbjct: 207 QAPCNQANYSQFHHPMYGNCYTFNNKNNSNLWMSSMPGVNNGLSLTLRTE-----QNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNVRPGVETSISMRKEALDSLGGNYGDCTENGSDVPVKNLYPS----KYTQQVCIHSCFQENMIKKCGCAYIFYPKPKGVEFCDYLKQSSWGYCYY------------------KLQAAFSLD---------SLGC-FSKCRKPCSVTNYK--------LSAGYSRWPSVK---SQDWIFEMLSL--------------------QNNYTINNKRNGVAKLNIFFKELNYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSVVEMAELIF 495
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Mouse
Match: Scnn1a (sodium channel, nonvoltage-gated 1 alpha [Source:MGI Symbol;Acc:MGI:101782]) HSP 1 Score: 55.0694 bits (131), Expect = 1.990e-7 Identity = 83/357 (23.25%), Postives = 135/357 (37.82%), Query Frame = 2 Query: 614 QDSISQLKISLFSHQDFFNCYTIEGEQE---YTKSIVGLIFILDIVPSDEIYELSKSFLIDMLNRGDGMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNCHDNQP-----NLYDLGRSFKYTHKHCMENQFQTEVINKCQCMLSNHPRP-------FLPNSSFPYCLKLNYTNNSEILDKRFSCVEKVQEHFSLNREIIENQFCSLRCRYSTYETTMSLTQWKASEQKLEHLQKLYRSYFSLKQKQSKENINNVINILKSSLKDTKDFRENLRKFHKLNKSLVRNKINDLTYVSITRKNFEISIKKEKLVLDSNTLLSRMGGLSSLCIGLTAAFVAEIIEFIY 1639 Q +Q S F H + NCYT + + S+ G+ L + E ++ I +L+ G ++++H +D+ GFN+ P SI + L +C +N NLY KYT + C+ + FQ +I KC C +P+P +L SS+ YC K+Q FSL+ SL C +S S+T +K L Y + S+K S++ I ++++ N + NK N + ++I K E + +LLS +G SL G + V E+ E I+ Sbjct: 207 QAPCNQANYSQFHHPMYGNCYTFNNKNNSNLWMSSMPGVNNGLSLTLRTE-----QNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNVRPGVETSISMRKEALDSLGGNYGDCTENGSDVPVKNLYPS----KYTQQVCIHSCFQENMIKKCGCAYIFYPKPKGVEFCDYLKQSSWGYCYY------------------KLQAAFSLD---------SLGC-FSKCRKPCSVTNYK--------LSAGYSRWPSVK---SQDWIFEMLSL--------------------QNNYTINNKRNGVAKLNIFFKELNYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSVVEMAELIF 495
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Match: sp|P55270|SCNNA_BOVIN (Amiloride-sensitive sodium channel subunit alpha OS=Bos taurus OX=9913 GN=SCNN1A PE=1 SV=2) HSP 1 Score: 70.4774 bits (171), Expect = 2.140e-11 Identity = 83/354 (23.45%), Postives = 133/354 (37.57%), Query Frame = 2 Query: 614 QDSISQLKISLFSHQDFFNCYTIEGEQE---YTKSIVGLIFILDIVPSDEIYELSKSFLIDMLNRGDGMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNCHDNQP-----NLYDLGRSFKYTHKHCMENQFQTEVINKCQCMLSNHPRPFLPNSSFPYCLKLNYTNNSEILDKR-----FSCVEKVQEHFSLNREIIENQFCSLRCRYSTYETTMSLTQWKASEQKLEHLQKLYRSYFSLKQKQSKENINNVINILKSSLKDTKDFRENLRKFHKLNKSLVRNKINDLTYVSITRKNFEISIKKEKLVLDSNTLLSRMGGLSSLCIGLTAAFVAEIIEFI 1636 QDS ++ S F H + NCYT + + S+ G+ L + E ++ I +L+ G ++++HE +D++GFNL P SI S+ RL +C N NLY+ KYT + C+ + FQ +I +C C +PRP + E D R C K+Q+ FS +R + C C + Y+ + S +QW ++ + Q L R N ++NK + + ++I K E + TLLS +G SL G + V E+ E I Sbjct: 267 QDSCNEANYSHFHHPMYGNCYTFNDKNSSNLWMSSMPGVNNGLSLTLRTE-----QNDFIPLLSTVTGARVMVHERDEPAFMDDAGFNLRPGVETSISMSKEAVDRLGGDYGDCTKNGSEVPVENLYNT----KYTQQVCIHSCFQESMIKECGCAYIFYPRP----------------DGVEFCDYRKHNSWGYCYYKLQDAFSSDRLGCFTK-CRKPCSVTIYKLSASYSQWPSATSQDWVFQMLSRQ----------------------------------------NNYTIKNKRDGVAKLNIFFKELNYKSNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELI 554
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Match: sp|Q25011|FANA_CORAP (FMRFamide-activated amiloride-sensitive sodium channel OS=Cornu aspersum OX=6535 PE=2 SV=1) HSP 1 Score: 65.4698 bits (158), Expect = 8.389e-10 Identity = 89/415 (21.45%), Postives = 176/415 (42.41%), Query Frame = 2 Query: 500 TFYMNLSPNESVKVGHS-RDIIRYCIIMKGHDIDVAENCQDSISQLKISLFSHQDFFNCYTIEGEQEYTKSIVG------LIFIL---DIVPSD-EIYELSKSFLIDMLNRGDGMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNCHDNQPNLYDLGRSFKYTHKHCMENQFQTEVINKCQCMLSNHPRPFLPNSSFPYCLK------LNYTN---NSEILDKRF------SCVEKVQEHFSLNREIIENQFCSLRCRYSTYETTMSLTQWKASEQKLEHLQKLYRSYFSLKQ----KQSKENINNVINILKSSL-KDTKDFRENLRKFHKLNKSLVRNKINDLTYVSITRKNF---EISI--KKEKLVLDSNTLLSRMGGLSSLCIGLTAAFVAEIIEFI 1636 FY NL ++ K+ H+ D++ +C + E C S S F ++FNC+T Q G LIF + D +P +Y + L G+++V+H P ++P + G ++ P +S+ RL P NC ++ N + +KYT C++ Q +I +C C S P N++F +K N++N N D+ F +C E+ Q++ + +R + C C ++Y ++SL+ W +L +++ ++ Q K + E + + + + L ++ + L K + L++ + + +DL ++ R N ++S+ ++ L + +GG L +G++ + E+IE + Sbjct: 162 AFYENLG-QDAKKLSHNLEDMLMHCRFNR-------ELCHVS----NFSTFFDGNYFNCFTFNSGQRLQMHATGPENGLSLIFSVEKDDPLPGTYGVYNFDNNIL-----HSAGVRVVVHAPGSMPSPVDHGIDIPPGYSSSVGLKAILHTRLPYPYGNCTNDMLNGI---KQYKYTFFACLQLCKQRLIIQRCGCKSSALPEVPSYNATFCGVIKDWQEINRNHSNEDHNQSEEDRAFIPTPYLACEEREQKNLNNDRTYELSCGCFQPCSETSYLKSVSLSYWPLEFYQLSAVERFFKQERQAGQNHFMKTAYEYLEKLAHPSQKHLARNDSHMDDILSKSYSLSEKEMAKEASDLIRQNMLRLNIYLEDLSVVEYRQLPAYGLADLFADIGGTLGLWMGISVLTIMELIELV 556
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Match: sp|H2QAR5|SCNNG_PANTR (Amiloride-sensitive sodium channel subunit gamma OS=Pan troglodytes OX=9598 GN=SCNN1G PE=3 SV=1) HSP 1 Score: 64.3142 bits (155), Expect = 2.043e-9 Identity = 66/260 (25.38%), Postives = 109/260 (41.92%), Query Frame = 2 Query: 536 KVGHSRDIIRYCIIMKGHDIDVAENCQDSISQLKISLFSHQDFFNCYTI---EGEQEYTKSIVGLIFILDIVPSDEIY---ELSKSFLIDMLNRGDGMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNCHDNQP-----NLYDLGRSFKYTHKHCMENQFQTEVINKCQCMLSNHPRPFLPNSSFPYCLKLNYTNNSEILDKRFSCVEKVQEHFSLNREIIENQFCSLRCRYSTYETTMSLTQWKA 1282 KVG S II K ++ E+ Q QL +LF H NCYT E E + S+ G + L ++ +Y E FL+ G K++IH P +++ G + + + SI T+ ++L P C ++ N+Y+ Y+ + C+ + FQT+++ KC C + P P N YC NY + + C ++ F + E+ C C + + T SL QW + Sbjct: 181 KVGGS-------IIHKASNVMHIESKQVVGFQLNFTLFHHPMHGNCYTFNNRENETILSTSMGGSEYGLQVI----LYINEEEYNPFLVS----STGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESFKLSEPYSQCTEDGSDVPIRNIYNAA----YSLQICLHSCFQTKMVEKCGCAQYSQPLPPAAN----YC---NYQQHPNWM----YCYYQLHRAF-VQEELGCQSVCKEACSFKEWTLTTSLAQWPS 409
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Match: sp|P37091|SCNNG_RAT (Amiloride-sensitive sodium channel subunit gamma OS=Rattus norvegicus OX=10116 GN=Scnn1g PE=1 SV=2) HSP 1 Score: 62.3882 bits (150), Expect = 6.878e-9 Identity = 86/347 (24.78%), Postives = 138/347 (39.77%), Query Frame = 2 Query: 641 SLFSHQDFFNCYTIEGEQEYT-------KSIVGLIFILDIVPSDEIYELSKSFLIDMLNRGDGMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNCHDNQP-----NLYDLGRSFKYTHKHCMENQFQTEVINKCQCMLSNHPRPFLPNSSFPYCLKLNYTNNSEILDKRFSCVEKVQEHFSLNREIIENQFCSLRCRYSTYETTMSLTQW--KASEQKLEHLQKLYRSYFSLKQKQSKENINNVINILKSSLKDTKDFRENLRKFHKLNKSLVRNKINDLTYVSITRKNFEISIKKEKLVLDSNTLLSRMGGLSSLCIGLTAAFVAEIIEFIY 1639 +LF H + NCYT ++ T S GL IL I +++ Y FL+ G K++IH+ + P I++ G + + SI T+ ++L P C ++ N+Y+ Y+ + C+ + FQT+++ KC C + P P N YC NY + + C ++ + F + E+ C C + + T SL QW +ASE+ L +N+L T D + + K KLNK+ DL + I K+ E LLS GG L + + V EIIE + Sbjct: 274 TLFHHPMYGNCYTFNNKENATILSTSMGGSEYGLQVILYI--NEDEY---NPFLVS----STGAKVLIHQQNEYPFIEDVGMEIETAMSTSIGMHLTESFKLSEPYSQCTEDGSDVPVTNIYNAA----YSLQICLYSCFQTKMVEKCGCAQYSQPLPPAAN----YC---NYQQHPNWM----YCYYQLYQAF-VREELGCQSVCKQSCSFKEWTLTTSLAQWPSEASEKWL-------------------------LNVL------TWDQSQQINK--KLNKT-------DLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFF 555
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Match: sp|H2Q5A1|SCNNA_PANTR (Amiloride-sensitive sodium channel subunit alpha OS=Pan troglodytes OX=9598 GN=SCNN1A PE=3 SV=2) HSP 1 Score: 61.2326 bits (147), Expect = 1.891e-8 Identity = 82/350 (23.43%), Postives = 129/350 (36.86%), Query Frame = 2 Query: 614 QDSISQLKISLFSHQDFFNCYTIEGEQE---YTKSIVGLIFILDIVPSDEIYELSKSFLIDMLNRGDGMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNCHDNQP-----NLYDLGRSFKYTHKHCMENQFQTEVINKCQCMLSNHPRPFLPNSSFPYCLKLNYTNNSEILDKRFSCVEKVQEHFSLNREIIENQFCSLRCRYSTYETTMSLTQWKASEQKLEHLQKLYRSYFSLKQKQSKENINNVINILKSSLKDTKDFRENLRKFHKLNKSLVRNKINDLTYVSITRKNFEISIKKEKLVLDSNTLLSRMGGLSSLCIGLTAAFVAEIIEFIY 1639 Q S +Q S F H + NCYT + + S+ G+ L ++ E ++ I +L+ G ++++H +D+ GFNL P SI + RL +C N NLY KYT + C+ + FQ +I +C C +PRP + YC +Y +S C K+Q FS + + C C ++Y+ + ++W + + Q L R N V NK N + V+I K E + TLLS +G SL G + V E+ E I+ Sbjct: 309 QVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAE-----QNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPS----KYTQQVCIHSCFQESMIKECGCAYIFYPRP----QNVEYC---DYRKHSSW----GYCYYKLQVDFSSDHLGCFTK-CRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQ----------------------------------------NNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELIF 597
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: A0A4E0RFC3 (FMRFamide-activated amiloride-sensitive sodium channel OS=Fasciola hepatica OX=6192 GN=D915_003846 PE=3 SV=1) HSP 1 Score: 339.732 bits (870), Expect = 4.375e-105 Identity = 200/526 (38.02%), Postives = 298/526 (56.65%), Query Frame = 2 Query: 107 SKTKLFFQTFSIRGVSKIHHAKSQFEKTLWISXXXXXXXXXXXXXXXXXKNYLQYITTWHTSTKFEDQAAFPGITFCAQNPFSKKSNEIWMRNQILSPTQMQDKXXXXXXXXXXXXXXXXXXXXXXXXXXXTFYMNLSPNESVKVGHSRDIIRYCIIMKGHDIDVAENCQ-DSISQLKISLFSHQDFFNCYTIEGE-QEYTKSIVGLIFILDIVPSDEIYELSKSFLIDMLNRGDGMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNCHDNQPNLYDLGRSFKYTHKHCMENQFQTEVINKCQCMLSNHPRPFLPNSS---FPYCLKLNYTNNSE----ILDKRFSCVEKVQEHFSLNRE-IIENQFCSLRCRYSTYETTMSLTQWKASEQKLEHLQKLYR---SYFSLKQKQSKENINNVINILKSSLKDTKDFRENLR--KFHKLNKSLVRNKINDLTYVSITRKNFEISIKKEKLVLDSNTLLSRMGGLSSLCIGLTAAFVAEIIEFIY 1639 SK KLF + SIRGV +I A++ F +TLWI FVI MT +L ++ L+ +YLQY T+WHT + +D++ FP IT CA NPFS K+N++W ++SP Q++ + +SL L + L D F +Y NLSP +S K+ H +II +CI+ VAE C+ ++++ + FSH +FNC TIEG E T I L+ + +VPS +I + +F++D RG+G+K+VIHE + P I+ GFN+ P++MN I+Y W RL TP C D+QP + DLG ++ Y C++ Q E+I +C CM S PRP PYC ++ ++ E +L +R +C E + RE II C RCR+ TY+T +S+T W+ S KL YR Y + + K+ +++ + + D+ D + N R + + TY+S+ R++F+ ++K+EKLV D+ LLSR+GGL SLCIGLT AF EIIEFIY Sbjct: 71 SKIKLFGEISSIRGVQRIFRAETPFIRTLWILFVISMTCLLTVSSFMLIVDYLQYTTSWHTRSLPDDKSEFPAITLCAHNPFSLKANKLWSTGHVISPNQVKSNMAAVSLEMLNQDKVEDSVIMALSDSFEFYYTNLSPEDSQKISHDFEIIPHCILYSPEHTVVAEKCEMENVTAMVRRTFSHPKYFNCLTIEGGGNESTSDISRLVLLAHLVPSSKIVQARSAFIMDTFTRGEGIKVVIHERNTYPQIERYGFNVQPNRMNEIIYETLSWKRLSTPVAPCKDSQPPISDLGVNYTYETSQCLDIATQEEMIRRCGCMNSEWPRPTRAVHGPRLVPYCTSMDRNSSVEVTATVLSERLACSRIFFEELPVIRERIIRAGICIPRCRFFTYDTKLSVTSWEPSPVKLSSYTANYRIVEEYLTEPIESKKKELSSFLQSIIDPTLDSADEQWNKRIGDYKQFGD-------GTYTYISLIRRDFDTTLKEEKLVFDAPILLSRIGGLCSLCIGLTMAFFIEIIEFIY 589
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: A0A074ZZG9 (Uncharacterized protein OS=Opisthorchis viverrini OX=6198 GN=T265_01528 PE=3 SV=1) HSP 1 Score: 316.235 bits (809), Expect = 6.715e-96 Identity = 190/527 (36.05%), Postives = 289/527 (54.84%), Query Frame = 2 Query: 98 NSKSKTKLFFQTFSIRGVSKIHHAKSQFEKTLWISXXXXXXXXXXXXXXXXXKNYLQYITTWHTSTKFEDQAAFPGITFCAQNPFSKKSNEIWMRNQILSPTQMQDKXXXXXXXXXXXXXXXXXXXXXXXXXXXTFYMNLSPNESVKVGHSRDIIRYCIIMKGHDIDVAENCQDSI-SQLKISLFSHQDFFNCYTIEGEQ-EYTKSIVGLIFILDIVPSDEIYELSKSFLIDMLNRGDGMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNCHDNQPNLYDLGRSFKYTHKHCMENQFQTEVINKCQCMLSNHPRPF---LPNSSFPYCLKLNYT-NNSEI---LDKRFSCVEKVQEHF-SLNREIIENQFCSLRCRYSTYETTMSLTQWKASEQKLEHLQKLYRSYFSLKQKQSKENI-NNVINILKSSLK--DTKDFRENLRKFHKLNKSLVRNKINDLTYVSITRKNFEISIKKEKLVLDSNTLLSRMGGLSSLCIGLTAAFVAEIIEFIY 1639 ++ + + F + SIRGV I A++ F ++LWI FVI MT +L + FL+++YL Y T WHT T +D+ AFP IT CA NPFS ++N W L+P Q+ + T ++ L N + L L D TFY NL P +GH ++ +C++ VAE C+ + ++L + SH +FNC+TIEG+ E TK I LI ++ +VPS +I E + SF++D RG+G+ V+HEP P+I+ G N+ P++MN I+Y W RL TPK C D P + DLG ++ YT C+ Q +++ +C C+ + +PRP P + PYC LN + N E+ L +RF C+ +V + + E C RC Y TYE +S+T W + L + YR L + S N+ N+ ++ +S++ + DF + R S + +TY+S+TR+ FE ++ E LV D L+SR+GGL SLCIGLT AF E++E+ Y Sbjct: 54 STPRRPRTFGEISSIRGVQNISRAETPFIRSLWILFVITMTSLLTIFSSFLIRDYLLYETNWHTRTLRDDKTAFPSITLCAHNPFSLEANRFWREGSTLNPKQINSRFTEIATEVLRQHNVAFSINLLLLDSIETFYTNLDPKVRYNIGHKMEMFPHCMVTSESAHIVAEKCKLELDTELHLHRISHPKYFNCWTIEGKALEATKEITRLIMLVQLVPSKKINEANLSFIMDTFTRGEGVISVVHEPGTYPEIEKHGINIQPNRMNQIIYKPVLWNRLATPKAPCSDQPPPISDLGINYTYTQGQCLNTVVQEQLLARCGCLNTEYPRPASTDFPVNPTPYCTSLNESLTNPEMASRLIERFQCIGEVMDQLKKIKEEATRQGRCPPRCSYFTYENRLSVTLWDPNAHNLAAYTERYRKLDGLLKAHSSMNMTNSFVSYWNASMQQFSSLDFESHNRPEQFAEYSQFVD--GSVTYISLTRQEFETTVMDEHLVFDVYILISRIGGLCSLCIGLTMAFFIEVVEYAY 578
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: H2KR43 (FMRFamide-activated amiloride-sensitive sodium channel OS=Clonorchis sinensis OX=79923 GN=CLF_105403 PE=3 SV=1) HSP 1 Score: 315.079 bits (806), Expect = 1.943e-95 Identity = 190/531 (35.78%), Postives = 284/531 (53.48%), Query Frame = 2 Query: 101 SKSKTKLFFQTFSIRGVSKIHHAKSQFEKTLWISXXXXXXXXXXXXXXXXXKNYLQYITTWHTSTKFEDQAAFPGITFCAQNPFSKKSNEIWMRNQILSPTQMQDKXXXXXXXXXXXXXXXXXXXXXXXXXXXTFYMNLSPNESVKVGHSRDIIRYCIIMKGHDIDVAENCQDSI-SQLKISLFSHQDFFNCYTIEGEQ-EYTKSIVGLIFILDIVPSDEIYELSKSFLIDMLNRGDGMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNCHDNQPNLYDLGRSFKYTHKHCMENQFQTEVINKCQCMLSNHPRPF---LPNSSFPYCLKLNYT-NNSEILDK---RFSCVEKVQEHF-SLNREIIENQFCSLRCRYSTYETTMSLTQWKASEQKLEHLQKLYRSYFSLKQKQSKENI--------NNVINILKSSLKDTKDFRENLRKFHKLNKSLVRNKINDLTYVSITRKNFEISIKKEKLVLDSNTLLSRMGGLSSLCIGLTAAFVAEIIEFIY 1639 + K + F + SIRGV I A++ F ++LWI FVI MT +L + FL+++YL Y T WHT T +D+ AFP IT CA NPFS ++N W +P Q+ + T ++ L N + L L D TFY NL P +GH ++ +C++ VAE C+ + ++L + SH +FNC+TIEG+ E TK I LI ++ +VPS +I E + SF++D RG+G+ V+HEP P+I+ G N+ P++MN I+Y W RL TPK C ++ P + DLG ++ YT C+ Q +++ +C C+ + +PRP P + PYC LN + N E+ K RF C+ +V + + E C RC Y TYE +S+T W + L + YR L + QS N+ N I S D+ + E ++ + V TY+S+TR+ FE ++ E+LV D L+SR+GGL SLCIGLT AF E++E+ Y Sbjct: 58 APRKPRTFGEISSIRGVQNISRAETPFIRSLWILFVITMTSLLTIFSSFLIRDYLLYETNWHTRTLRDDKTAFPSITLCAHNPFSLEANRFWREGSTPNPKQINSRFTEIATEVLRQHNVAFSINLLLLDSIETFYTNLDPKVRYNIGHKMEMFPHCMVTSESAHIVAEKCKLELDTELHLHRISHPKYFNCWTIEGKALEATKEITRLIMLVQLVPSKKINEANLSFIMDTFTRGEGVISVVHEPGTYPEIEKHGINIQPNRMNQIIYKPVLWNRLATPKAPCSEHPPPISDLGVNYTYTQGQCLNTVLQEQLLARCGCLNTEYPRPASTDFPVNPTPYCTSLNESLTNPEMASKLIERFQCIGEVMDRLKEIKEEAARQGRCPPRCSYFTYENRLSVTLWDPNAHNLAAYTERYRKLDGLLKAQSSMNMKTSFVSYWNASIQQFSSLDLDSHNQPERFAEYSQFVDGSV-------TYISLTRQEFETTVMDERLVFDVYILISRIGGLCSLCIGLTMAFFIEVVEYAY 581
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: A0A3R7EZA3 (FMRFamide-activated amiloride-sensitive sodium channel OS=Clonorchis sinensis OX=79923 GN=CSKR_10046s PE=3 SV=1) HSP 1 Score: 314.309 bits (804), Expect = 3.519e-95 Identity = 187/526 (35.55%), Postives = 289/526 (54.94%), Query Frame = 2 Query: 101 SKSKTKLFFQTFSIRGVSKIHHAKSQFEKTLWISXXXXXXXXXXXXXXXXXKNYLQYITTWHTSTKFEDQAAFPGITFCAQNPFSKKSNEIWMRNQILSPTQMQDKXXXXXXXXXXXXXXXXXXXXXXXXXXXTFYMNLSPNESVKVGHSRDIIRYCIIMKGHDIDVAENCQDSI-SQLKISLFSHQDFFNCYTIEGEQ-EYTKSIVGLIFILDIVPSDEIYELSKSFLIDMLNRGDGMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNCHDNQPNLYDLGRSFKYTHKHCMENQFQTEVINKCQCMLSNHPRPF---LPNSSFPYCLKLNYT-NNSEILDK---RFSCVEKVQEHF-SLNREIIENQFCSLRCRYSTYETTMSLTQWKASEQKLEHLQKLYRSYFSLKQKQSKENI-NNVINILKSSLKDTKDFRENLRKFHKLNKSLVRNKIND--LTYVSITRKNFEISIKKEKLVLDSNTLLSRMGGLSSLCIGLTAAFVAEIIEFIY 1639 + K + F + SIRGV I A++ F ++LWI FVI MT +L + FL+++YL Y T WHT T +D+ AFP IT CA NPFS ++N W +P Q+ + T ++ L N + L L D TFY NL P +GH ++ +C++ VAE C+ + ++L + SH +FNC+TIEG+ E TK I LI ++ +VPS +I E + SF++D RG+G+ V+HEP P+I+ G N+ P++MN I+Y W RL TPK C ++ P + DLG ++ YT C+ Q +++ +C C+ + +PRP P + PYC LN + N E+ K RF C+ +V + + E C RC Y TYE +S+T W + L + YR L + QS N+ + ++ +S++ +L ++ + ++ D +TY+S+TR+ FE ++ E+LV D L+SR+GGL SLCIGLT AF E++E+ Y Sbjct: 58 APRKPRTFGEISSIRGVQNISRAETPFIRSLWILFVITMTSLLTIFSSFLIRDYLLYETNWHTRTLRDDKTAFPSITLCAHNPFSLEANRFWREGSTPNPKQINSRFTEIATEVLRQHNVAFSINLLLLDSIETFYTNLDPKVRYNIGHKMEMFPHCMVTSESAHIVAEKCKLELDTELHLHRISHPKYFNCWTIEGKALEATKEITRLIMLVQLVPSKKINEANLSFIMDTFTRGEGVISVVHEPGTYPEIEKHGINIQPNRMNQIIYKPVLWNRLATPKAPCSEHPPPISDLGVNYTYTQGQCLNTVLQEQLLARCGCLNTEYPRPASTDFPVNPTPYCTSLNESLTNPEMASKLIERFQCIGEVMDRLKEIKEEAARQGRCPPRCSYFTYENRLSVTLWDPNAHNLAAYTERYRKLDGLLKAQSSMNMKTSFVSYWNASIQQFSSL--DLESHNQPERFAEYSQFVDGSVTYISLTRQEFETTVMDERLVFDVYILISRIGGLCSLCIGLTMAFFIEVVEYAY 581
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: A0A4S2LSS8 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_005099 PE=3 SV=1) HSP 1 Score: 313.923 bits (803), Expect = 6.343e-95 Identity = 187/526 (35.55%), Postives = 288/526 (54.75%), Query Frame = 2 Query: 101 SKSKTKLFFQTFSIRGVSKIHHAKSQFEKTLWISXXXXXXXXXXXXXXXXXKNYLQYITTWHTSTKFEDQAAFPGITFCAQNPFSKKSNEIWMRNQILSPTQMQDKXXXXXXXXXXXXXXXXXXXXXXXXXXXTFYMNLSPNESVKVGHSRDIIRYCIIMKGHDIDVAENCQDSI-SQLKISLFSHQDFFNCYTIEGEQ-EYTKSIVGLIFILDIVPSDEIYELSKSFLIDMLNRGDGMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNCHDNQPNLYDLGRSFKYTHKHCMENQFQTEVINKCQCMLSNHPRPF---LPNSSFPYCLKLNYT-NNSEILDK---RFSCVEKVQEHF-SLNREIIENQFCSLRCRYSTYETTMSLTQWKASEQKLEHLQKLYRSYFSLKQKQSKENI-NNVINILKSSLKDTKDFRENLRKFHKLNKSLVRNKIND--LTYVSITRKNFEISIKKEKLVLDSNTLLSRMGGLSSLCIGLTAAFVAEIIEFIY 1639 + K + F + SIRGV I A++ F ++LWI FVI MT +L + FL+++YL Y T WHT T +D+ AFP IT CA NPFS ++N W +P Q+ + T ++ L N + L L D TFY NL P +GH ++ +C++ VAE C+ + ++L + SH +FNC+TIEG+ E TK I LI ++ +VPS +I E + SF++D RG+G+ V+HEP P+I+ G N+ P++MN I+Y W RL TPK C D+ P + DLG ++ YT C+ Q +++ +C C+ + +PRP P + PYC LN + N E+ K RF C+ +V + + E C RC Y TYE +S+T W + L + YR L + S N+ + ++ +S++ +L ++ + ++ D +TY+S+TR+ FE ++ E+LV D L+SR+GGL SLCIGLT AF E++E+ Y Sbjct: 65 APRKPRTFGEISSIRGVQNISRAETPFIRSLWILFVITMTSLLTIFSSFLIRDYLLYETNWHTRTLRDDKTAFPSITLCAHNPFSLEANRFWREGSTPNPKQINSRFTEIATEVLRQRNVAFSINLLLLDSIETFYTNLDPKVRYNIGHKMEMFPHCMVTSESAHIVAEKCKLELDTELHLHRISHPKYFNCWTIEGKALEATKEITRLIMLIQLVPSKKINEANLSFIMDTFTRGEGVISVVHEPGTYPEIEKHGINIQPNRMNQIIYKPVLWNRLATPKAPCSDHPPPISDLGVNYTYTQGQCLNTVLQEQLLARCGCLNTEYPRPASTDFPVNPTPYCTSLNESLTNPEMASKLIERFQCIGEVMDRLKEIKEEAARQGRCLPRCSYFTYENRLSVTLWDPNAHNLAAYTERYRKLDGLLKAHSSMNLTTSFVSYWNASIQQFSSL--DLESHNQPERFAEYSQFVDGSVTYISLTRQEFETTVMDERLVFDVYILISRIGGLCSLCIGLTMAFFIEVVEYAY 588
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Sea Lamprey
Match: SCNN1G (sodium channel epithelial 1 gamma subunit [Source:HGNC Symbol;Acc:HGNC:10602]) HSP 1 Score: 53.5286 bits (127), Expect = 1.003e-7 Identity = 48/182 (26.37%), Postives = 78/182 (42.86%), Query Frame = 2 Query: 791 LNRGDGMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNCHDNQPN-----LYDLGRSFKYTHKHCMENQFQTEVINKCQCMLSNHPRPFLPNSSFPYCLKLNYTNNSEILDKRFSCVEKVQEHFSLNREIIENQFCSLRCRYSTYETTMSLTQWKASEQKLEHLQKLYR 1321 L G G KI IH + P I+ G ++ P+ +S+ D +L P +C + + LYD Y+ + C + FQ E+I C C +N+ +P S F NY NN C ++ + + + E+ Q C C + +E T+SL W + K L+ L + Sbjct: 315 LAMGAGAKIGIHLQNTTPFIEAVGIDIPPAMESSLGLRVNDVQKLGDPYSDCTMDGSDIDVKSLYD----SPYSVQTCQNSCFQWEMIKSCGC--ANYEQPLPEGSRF-----CNYDNNP----GWEYCYYRLYDMY-IKEELKCIQVCRQICSETEHEVTLSLADWPSKASKGWLLRALSK 480
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Sea Lamprey
Match: SCNN1A (sodium channel epithelial 1 alpha subunit [Source:HGNC Symbol;Acc:HGNC:10599]) HSP 1 Score: 50.447 bits (119), Expect = 8.343e-7 Identity = 59/254 (23.23%), Postives = 101/254 (39.76%), Query Frame = 2 Query: 611 CQDSISQLKISLFSHQDFFNCYTIEGEQE---YTKSIVGLIFILDIVPSDEIYELSKSFLIDMLNRGDGMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNCHD---NQP--NLYDLGRSFKYTHKHCMENQFQTEVINKCQCMLSNHPRPFLPNSSFPYCLKLNYTNNSEILDKRFSCVEKVQEHFSLNREIIENQF-----CSLRCRYSTYETTMSLTQW--KASEQKLEHLQKLYRSY 1327 C DS + S F H + NCYT + S G + L ++ E ++ I L+ G +I++H+ + P ++ GF++ P S+ + R+ P NC + N P NLY + + C FQ ++ C C +P P PN+S YC +Y N + ++ L R+ I ++ C+ C + T W +SE+ + +L L +Y Sbjct: 225 CSDS----EYSRFHHPTYGNCYTFNSANSSKLWQASKPGRDYGLSLILRTE-----QNDYIPFLSTVAGARIMVHDQESPPFMEEGGFDMRPGFETSLGIRMLEATRMPDPYGNCTEDGSNVPVLNLYSSAYTVQVPECSC----FQLALVEACGCGYYFYPLP--PNAS--YC---SYNNTA----------WAGHCYYKLYRQFISDELGCVDKCAQPCTTKRFAVTPGYAAWPDSSSEKWIFNLLSLQNNY 448
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Sea Lamprey
Match: SCNN1B (sodium channel epithelial 1 beta subunit [Source:HGNC Symbol;Acc:HGNC:10600]) HSP 1 Score: 49.6766 bits (117), Expect = 1.613e-6 Identity = 59/261 (22.61%), Postives = 107/261 (41.00%), Query Frame = 2 Query: 617 DSISQLKISLFSHQDFFNCYTIE-GEQEYTKSI--VGLIFILDIVPSDEIYELSKSFLIDMLNRGDGMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNCHDNQPNL--YDLGRSFKYTHKHCMENQFQTEVINKCQCMLSNHPRPFLPNSSFPYCLKLNYTNNSEILDKRFSCVEKVQEHFSLNREIIENQFCSLRCRYSTYETTMSLTQW--KASEQKLEHLQKLYRSYFSLKQKQSKENINNVIN 1378 D+ S + F H + NC+ GE E + G+ + L +V S + + I L G I++H+ + P + + G + S+ R P +C + +L +L Y+ + C+ + FQT++I C C +P P P YC N+T R+ C K+ E F + ++ C C S Y+ ++S++ W ++SE + H+ K+ K N++ + N Sbjct: 258 DTCSATNFTTFFHPMYGNCFIFNWGENETVMQVSNPGVEYGLKLVLS-----IDQDEYIPFLTTIAGAVIMVHDQNTYPFLSDLGVFVKTGVETSVGIEVGQLQRQGAPYSDCTMDGTDLPITNLYNGTAYSVQACLRSCFQTKMIEMCGCGYYLYPLP--PGEK--YCQNQNFTG------WRY-CYYKLYEQF-VEEDMDCYTICKQPCIESEYKMSISMSDWPSQSSEDWIFHILS----------KERKHNVSRIFN 491
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Nematostella
Match: EDO42137 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S2F2]) HSP 1 Score: 50.447 bits (119), Expect = 1.397e-6 Identity = 64/285 (22.46%), Postives = 115/285 (40.35%), Query Frame = 2 Query: 806 GMKIVIHEPHNLPDIDNSGFNLHPSK-----MNSIVYSQTDWYRLRTPKVNCHDNQPNLYDLGRSFKYTHKHCMENQFQTEVINKCQCMLSNHPRPFLPNSSFPYCLKLNYTNNSEILDKRFSCVEKVQEHF---SLNREIIENQFCSLRCRYSTYETTMSLTQWKASEQKLEHLQKLYRSYFSLKQKQSKENINNVINILKSSLKDTKDFRENLRKFHKLNKSLVRNKINDLTYVSITRKNFEISIKKEKLVLDSNTLLSRMGGLSSLCIGLTAAFVAEIIEFI 1636 GMK+ I + LP G + P + M + + D ++ R+ + + + NL+ G + Y+ C + I +C C +N+ P + + P C +L NS I+D C+ K + F S +RE C C +++ T+S +W A ++ Y + ++ V+N + SS EN+ + H +L Y+ + +E L +LLS +GG + IG++A AE+IE + Sbjct: 250 GMKVTISDQGVLPFPGQQGIRIMPGQSTGIQMTKLQTRRIDPFKNRSCESSNEMSDKNLF-FGYNMTYSIMACKYSCLNARKIERCGC--TNYNTPEMQKRNIPLCNRL----NSTIID----CLNKAYDTFEDGSCDRE------CPPSCSEVSFDLTVSSARWPARSFEVTK----YAYFLRVR----------VLNKIASSSSKYFVNSENIAQVHVY--------YGELDYLLV----------QETLAYTFMSLLSDIGGQMGMWIGISALTCAELIELV 485
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Nematostella
Match: EDO29539 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T3C7]) HSP 1 Score: 47.3654 bits (111), Expect = 8.136e-6 Identity = 50/221 (22.62%), Postives = 80/221 (36.20%), Query Frame = 2 Query: 638 ISLFSHQDFFNCYTIEGEQEYT------KSIVGLIFILDIVPSDEIYELSKSFLIDMLNRGDGMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTP-KVNCHDNQPNLYDLGRSF--KYTHKHCMENQFQTEVINKCQCM-LSNHPRPFLPNSSFPYCLKLNYTNNSEILDKRFSCVEKVQEHFSLNREIIE--NQFCSLRCRYSTYETTMS 1264 S F H + +C+T + ++ I GL L++ D + ++ G K+++H+P P I+ +GF L P + LR P + C + N+ D R F YT C + I KC C + F+ + S +CL L RE E + C + C Y+ YET +S Sbjct: 22 FSTFEHLRYGSCHTFNSDGQFGLKVDSIGPISGLQLRLNVEEKDHV--------SNLYGLQAGFKVLVHDPREHPMIEETGFALQPGTHTFCSVRMKKYVNLRAPYRTECGE---NITDFNRYFNVNYTMAICSKQCLHDYGIKKCGCQPIFEITSEFMDSGSLTHCLLLG----------------------PYPREAAECFKKSCPVPCYYTKYETKLS 209
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Nematostella
Match: EDO30893 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SZH4]) HSP 1 Score: 47.3654 bits (111), Expect = 8.235e-6 Identity = 62/281 (22.06%), Postives = 106/281 (37.72%), Query Frame = 2 Query: 806 GMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTP-KVNCHDNQPNLYDLGRSFK--YTHKHCMENQFQTEVINKCQCMLSNHPRPFLPNSSFPYCLK-LNYTNNSEILDKRFSCVEKVQEHFSLNREIIENQFCSLRCRYSTYETTMSLTQWKASEQKLEHLQKLYRSYFSLKQKQSKENINNVINILKSSLKDTKDFRENLRKFHKLNKSLVRNKINDLTYVSITRKNFEISIKKEKLVLDSNTLLSRMGGLSSLCIGLTAAFVAEIIEFI 1636 G K+++H+ P ++ +GF L P + L TP C + N+ D R F Y+ C + I KC C +P P + YC K + + N +IL F+ E F ++C + C Y+ YET +S Y S S N + L + L ++KD + + N + + +L+Y I ++K DS +L+ +GG L +G++ V E ++ + Sbjct: 49 GFKVLVHDRKEYPIMEQTGFALQPGTHTFCSTKLKKYKNLPTPYNTKCGE---NITDFNRYFSVNYSMSTCGKQCLHDYGIKKCGC------QPIYPITMKLYCQKRIVFKNAPKILIFLFA-----AECF--------KKYCPVPCDYTKYETKLS-----------------YASAIS----------NALARSLPTHLTESKDVADAFK-----NVATLDVYFEELSYDKI----------EQKPSFDSWSLIGNIGGYLGLFLGMSVLTVMEFLDLL 265
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000035185.1 (SMESG000035185.1) HSP 1 Score: 980.319 bits (2533), Expect = 0.000e+0 Identity = 554/555 (99.82%), Postives = 555/555 (100.00%), Query Frame = 2 Query: 80 MIELSENSKSKTKLFFQTFSIRGVSKIHHAKSQFEKTLWISXXXXXXXXXXXXXXXXXKNYLQYITTWHTSTKFEDQAAFPGITFCAQNPFSKKSNEIWMRNQILSPTQMQDKXXXXXXXXXXXXXXXXXXXXXXXXXXXTFYMNLSPNESVKVGHSRDIIRYCIIMKGHDIDVAENCQDSISQLKISLFSHQDFFNCYTIEGEQEYTKSIVGLIFILDIVPSDEIYELSKSFLIDMLNRGDGMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNCHDNQPNLYDLGRSFKYTHKHCMENQFQTEVINKCQCMLSNHPRPFLPNSSFPYCLKLNYTNNSEILDKRFSCVEKVQEHFSLNREIIENQFCSLRCRYSTYETTMSLTQWKASEQKLEHLQKLYRSYFSLKQKQSKENINNVINILKSSLKDTKDFRENLRKFHKLNKSLVRNKINDLTYVSITRKNFEISIKKEKLVLDSNTLLSRMGGLSSLCIGLTAAFVAEIIEFIYXXXXXXXXXXXXXXXXXXXXXXXXTGSNNLNASVE 1744 MIELSENSKSKTKLFFQTFSIRGVSKIHHAKSQFEKTLWISFVIIMTFILILTMIFLVKNYLQYITTWHTSTKFEDQAAFPGITFCAQNPFSKKSNEIWMRNQILSPTQMQDKLTLLSLNALENLNNSLLSYLRLYDLFSTFYMNLSPNESVKVGHSRDIIRYCIIMKGHDIDVAENCQDSISQLKISLFSHQDFFNCYTIEGEQEYTKSIVGLIFILDIVPSDEIYELSKSFLIDMLNRGDGMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNCHDNQPNLYDLGRSFKYTHKHCME+QFQTEVINKCQCMLSNHPRPFLPNSSFPYCLKLNYTNNSEILDKRFSCVEKVQEHFSLNREIIENQFCSLRCRYSTYETTMSLTQWKASEQKLEHLQKLYRSYFSLKQKQSKENINNVINILKSSLKDTKDFRENLRKFHKLNKSLVRNKINDLTYVSITRKNFEISIKKEKLVLDSNTLLSRMGGLSSLCIGLTAAFVAEIIEFIYIICKCNKSRCSKSRIRRKRNCSNSTGSNNLNASVE Sbjct: 1 MIELSENSKSKTKLFFQTFSIRGVSKIHHAKSQFEKTLWISFVIIMTFILILTMIFLVKNYLQYITTWHTSTKFEDQAAFPGITFCAQNPFSKKSNEIWMRNQILSPTQMQDKLTLLSLNALENLNNSLLSYLRLYDLFSTFYMNLSPNESVKVGHSRDIIRYCIIMKGHDIDVAENCQDSISQLKISLFSHQDFFNCYTIEGEQEYTKSIVGLIFILDIVPSDEIYELSKSFLIDMLNRGDGMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNCHDNQPNLYDLGRSFKYTHKHCMESQFQTEVINKCQCMLSNHPRPFLPNSSFPYCLKLNYTNNSEILDKRFSCVEKVQEHFSLNREIIENQFCSLRCRYSTYETTMSLTQWKASEQKLEHLQKLYRSYFSLKQKQSKENINNVINILKSSLKDTKDFRENLRKFHKLNKSLVRNKINDLTYVSITRKNFEISIKKEKLVLDSNTLLSRMGGLSSLCIGLTAAFVAEIIEFIYIICKCNKSRCSKSRIRRKRNCSNSTGSNNLNASVE 555
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000081715.1 (SMESG000081715.1) HSP 1 Score: 501.901 bits (1291), Expect = 5.380e-172 Identity = 268/518 (51.74%), Postives = 371/518 (71.62%), Query Frame = 2 Query: 107 SKTKLFFQTFSIRGVSKIHHAKSQFEKTLWISXXXXXXXXXXXXXXXXXKNYLQYITTWHTSTKFEDQAAFPGITFCAQNPFSKKSNEIWMRNQILSPTQMQDKXXXXXXXXXXXXXXXXXXXXXXXXXXXTFYMNLSPNESVKVGHSRDIIRYCIIMKGHDIDVAENCQDSISQLKISLFSHQDFFNCYTIEGEQEYTKSIVGLIFILDIVPSDEIYELSKSFLIDMLNRGDGMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNCHDNQPNLYDLGRSFKYTHKHCMENQFQTEVINKCQCMLSNHPRPFLPNSSFPYCLKLNYTNNSEILDKRFSCVEKVQEHFSLNREIIENQFCSLRCRYSTYETTMSLTQWKASEQKLEHLQKLYRSYFSLKQKQSKENINNVINILKSSLKDTKDFRENLRKFHKLNKSLVRNKI-------NDLTYVSITRKNFEISIKKEKLVLDSNTLLSRMGGLSSLCIGLTAAFVAEIIEFIY 1639 SKTKLF Q SIRG+SKIH AK++FE+ LW FVI+MT +L + M+FL+++YLQY T WHTST+ + + FP IT CAQNPFS +N +W + +I+SP+++QD LT++SLNA ++ N L YLRLYDLFSTFYMNL +++K+GHS+D+IRYCI++ +DI +AE C + I LFSHQ++FNCYTIEG ++YT ++GLI ++ I+PS++I ELS SFL+D+L RG+G+K+ +H+P PDI+NSG N+HP+KMNS+VYS T W R+ T K C D Q + DL R FKY C+ + Q ++I +C CMLSN PRP+ PN + PYC+KL ++++ +R SCVE +Q R+ I+N C L+C+++TYETTMSLT+W A+E KL++L+ LYRSYF+ + S ENI + +IL +SL + + R H++NK+ N I N TY+S+ R+NF+I K EKLVLDSNTL SRMGGL+S+CIGLTAA AE IEF+Y Sbjct: 2 SKTKLFCQISSIRGISKIHSAKTKFERFLWTGFVILMTCVLFVQMVFLIQDYLQYTTAWHTSTELDYPSPFPAITLCAQNPFSIDANRLWSKRKIMSPSELQDNLTIMSLNAFDDKNLDGLEYLRLYDLFSTFYMNLPFLDTIKLGHSKDMIRYCILIYKNDIIIAEKCDLKNEKFNIKLFSHQEYFNCYTIEGLEQYTTDVIGLILLVQIIPSEKIPELSNSFLVDILQRGEGLKVAVHQPQTYPDIENSGINMHPAKMNSLVYSPTKWIRMSTSKNPCRDKQKPINDLNRHFKYAFTQCVSAEIQRQIIKQCGCMLSNAPRPYPPNETIPYCIKLVSPTKAKLILERLSCVENIQSQSVEIRKTIQNDLCFLKCQFTTYETTMSLTRWTANELKLKNLENLYRSYFAYRHNSSSENIVKIKSILLNSLNRSHNLR------HQINKNQFNNLINYSRFDENAFTYISLMRRNFDIQWKTEKLVLDSNTLFSRMGGLTSICIGLTAAVFAEFIEFLY 513
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000064696.1 (SMESG000064696.1) HSP 1 Score: 317.39 bits (812), Expect = 3.081e-100 Identity = 191/546 (34.98%), Postives = 306/546 (56.04%), Query Frame = 2 Query: 32 LYSIRSHELSQKNRKKMIELSENSKSKTKLFFQTFSIRGVSKIHHAKSQFEKTLWISXXXXXXXXXXXXXXXXXKNYLQYITTWHTSTKFEDQAAFPGITFCAQNPFSKKSNEIWMRNQILSPTQMQDKXXXXXXXXXXXXXXXXXXXXXXX-XXXXTFYMNLSPNESVKVGHSRDIIRYCIIMKGHDIDVAENCQDSISQL--KISLFSHQDFFNCYTIEGEQEYT-KSIVGLIFILDIVPSDEIYELSKSFLIDMLNRGDGMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNCHDNQPNLYDLGRSFKYTHKHCMENQFQTEVINKCQCMLSNHPRPFLPNSSFPYCLKLNYTNNSEILDKRFSCVEKVQEHFSLNREIIENQF----CSLRCRYSTYETTMSLTQWKASEQKLEHLQKLY-RSYFSLKQKQSKENINNVINILKSSLKDTKDFRENLRKFHKLNKSLVR-NKINDLTYVSITRKNFEISIKKEKLVLDSNTLLSRMGGLSSLCIGLTAAFVAEIIEFIY 1639 + S + Q +RK + K+ LF + SIRG+ KI A + F K LWI+FV MT +L L L+K+YL Y T WH TKF+D + FP IT C+ NPFS ++N +W + +P +++L + ++ + + L ++ D +YMN+ + S+K+ H ++++YC I I + NC+ ++ KI +FSHQ FFNCYTI+ Y+ ++I LI ++ + P+ +I EL SFL+D+L RG+G+K+VIHEP++ P+I+ G ++ P KMN+I Y W R TP C + Q ++DL R F Y+ CM Q ++I C CM + PRPF+PN YC+ L + N+S+I K + F++N + ++ Q+ C +C Y TY T +S+T+W S +KL + L ++ LK + +E+ + I+ +++++ ++ +N S + N TY+S++RK IK E+LVLD L+SR+GGL SL IGLT +F E++EF Y Sbjct: 1 MISTEKETIKQASRKSESNVLVIDKNAFNLFCEISSIRGMHKITKAPTLFLKVLWIAFVFCMTSLLFLVTGLLIKDYLNYYTAWHVRTKFDDNSEFPAITLCSHNPFSLRANSLWKKPNAPNPEMFRERLKQVVIDEVNTTKDPNELTLMMFHDKIENYYMNIDYDFSLKISHGTEMLKYCAIFSDGLIIITYNCETEKDKVVEKI-VFSHQKFFNCYTIQQTSNYSQQTITSLIILVSLTPAADIPELKNSFLMDILERGEGLKLVIHEPNSYPEIEEEGIDVQPGKMNNIKYEPVKWARHSTPPQKCKNGQSPIFDLKRQFNYSFSFCMNYNLQLKLIETCGCMNALFPRPFIPNEKIGYCMNLTHRNSSQIFTNL-----KCAQDFTMNVKTLKKQWENTKCMQKCNYFTYNTELSITKWVPSYEKLFRIADLINKTEIYLKNHRERESKEDYISYIQANITNS-----------YINSSFLDLENENKFTYISLSRKTRNTVIKDEELVLDLAILMSRIGGLCSLFIGLTVSFFIELVEFGY 529
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000016707.1 (SMESG000016707.1) HSP 1 Score: 310.457 bits (794), Expect = 2.731e-97 Identity = 191/533 (35.83%), Postives = 303/533 (56.85%), Query Frame = 2 Query: 107 SKTKLFFQTFSIRGVSKIHHAKSQFEKTLWISXXXXXXXXXXXXXXXXXKNYLQYITTWHTSTKFEDQAAFPGITFCAQNPFSKKSNEIWMRNQILSPTQMQDKXXXXXXXXXXXXXXXXXXXXXXXXXXXTFYMNLSPNESVKVGHSRDIIRYCIIMKGHDIDVAENC-QDSISQLKISLFSHQDFFNCYTIEGEQEY----------TKSIVGLIFILDIVPSDEIYELSKSFLIDMLNRGDGMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNCHDNQPNLYDLGRSFKYTHKHCMENQFQTEVINKCQCMLSNHPRPFLPNSSFPYCLKLNYTNNSEILDKRFSCV-EKVQEHFSLNREIIENQFCSLRCRYSTYETTMSLTQWKASEQKLEHLQKLYRSY------FSLKQKQSKENI----NNVINILKSSLKDTKDFRENLRKFHKLNKSLVRNKINDLTYVSITRKNFEISIKKEKLVLDSNTLLSRMGGLSSLCIGLTAAFVAEIIEFIY 1639 SK +F + S+RG+ KIH +K+ F K LWI+FV M+ +LI+ LV ++ Y T WH ST+ +++ FP I+ C+ NPFSK+++ W +IL P + +++L + + +++ N + L + +Y N+ S+K+GH R I++YC++ +AE+C ++ + +S FSH ++FNC+TIE + E T V LI ++++ ++++ ++SF++D L RG+G++IVIH + PDID +G N+ P KMN + + W R +PK C D+QP + DL R + YT C++ E++ KCQCM + PRP LP+ PYC +Y+ N + KR CV E+V + + C C ++TY++T+S+T+WK S KL + K YRS SL K + E I +N IN LK LK ++ L HK + +++N Y+++ RKNF+ + K EKL +D +SR+GGL SLCIGLT AF EIIEF+Y Sbjct: 51 SKFAIFCEASSVRGMQKIHKSKTPFLKALWIAFVFFMSILLIIISTNLVIDFRNYHTAWHVSTELDEKTRFPAISICSHNPFSKQASRYWKEGKILPPEKFRERLFEVEMELIKSGNLPGQTLLDKAEE---YYGNVDYPSSIKLGHVRKILQYCVVQNDGFTIIAEDCLVENETGFTVSQFSHYNYFNCFTIEAKSEKNGLIKSYGDKTNETVSLILLINVNLFSDLFQANESFVMDSLTRGEGLRIVIHRVGSYPDIDKNGINIQPGKMNEVNFQNIHWTRYSSPKRECKDDQPPIVDLDRIYDYTFAQCLDAIVNKELVEKCQCMSTIWPRPQLPSKDVPYC--NDYSGNLTTIVKRTQCVYEEVFQKLKPIKAAAVGTKCWPLCTFNTYDSTLSITRWKPSLLKLRQITKRYRSVNKYIDDISL-AKNNTETIEQLKSNYINELKRELK----YKPTLSH-HKSEEIFNEHQMN---YINLVRKNFDTTKKIEKLFIDIYIFISRVGGLCSLCIGLTTAFFIEIIEFVY 569
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000045131.1 (SMESG000045131.1) HSP 1 Score: 295.434 bits (755), Expect = 3.686e-92 Identity = 185/541 (34.20%), Postives = 304/541 (56.19%), Query Frame = 2 Query: 59 SQKNRKKMIELSENSKSKTKLFFQTFSIRGVSKIHHAKSQFEKTLWISXXXXXXXXXXXXXXXXXKNYLQYITTWHTSTKFEDQAAFPGITFCAQNPFSKKSNEIWMRNQILSPTQMQDKXXXXXXXXXXXXXXXXXXXXXXXXXXXTFYMNLSPNESVKVGHSRDIIRYCIIMKGHDIDVAENCQ-DSISQLKISLFSHQDFFNCYTIEGEQE----------YTKSIVGLIFILDIVPSDEIYELSKSFLIDMLNRGDGMKIVIHEPHNLPDIDNSGFNLHPSKMNSIVYSQTDWYRLRTPKVNCHDNQPNLYDLGRSFKYTHKHCMENQFQTEVINKCQCMLSNHPRPFLPNSSFPYCLKLNYTNNSEILDKRFSCVEKVQEHFSLNREIIENQFCSLRCRYSTYETTMSLTQWKASEQKLEHLQKLYRSYFSLKQKQSKENINNVINILKSSLKDTKDFRENLRKFHKLNKSLVRNKIND---LTYVSITRKNFEISIKKEKLVLDSNTLLSRMGGLSSLCIGLTAAFVAEIIEFIY 1639 S N K L+ S LF + SIRG+ KI A + F +++WI +VI+MT +L +T FL +++ Y T WHTST F+++ FP I+ C+ NPFS+ +N +W N +++P + ++ LL+ ++ + N+ LYD +Y N+ SV + H +I+RYC++ + +AE C S ++ FS+ +FNC+TIE + E T+ ++ +I ++ I P ++ +++ SF++D L RG G+K+V+HE P+I+N G NL P KMN I + W R +PK C +NQ N+ DLG S+KYT C+E + Q I C CM SN PRP P+ + PYC N++ +++ + KR+ C +++ +++++ + C C Y TY+T +S+T WK S KL + ++Y+ + ++ E + LK +DT ++K+L N + D TY+++ RKNF+ K E+LV+D++ +SR+GGL SL +GLT A AE+IEF Y Sbjct: 68 SGYNEPKQKPLANPQPSPLTLFCEAISIRGMQKIARAPNNFLRSVWIGYVILMTTLLTVTSYFLFRDFFNYNTAWHTSTAFDEKTEFPAISICSHNPFSENANRMWQENLVMTPKKFEE---LLTNVSINMVKNNRGGGEILYDSAEYYYGNIEYESSVNLSHKEEILRYCVLTTDAYVYIAEQCDLASYVAYRLRKFSNSKYFNCFTIEEDPEKLKTHSADVVSTRELLSIIILIQITPESDLTQINSSFVMDTLTRGTGVKVVLHEVGTSPEIENYGINLQPGKMNEISFETIHWNRYNSPKRPCLNNQSNIIDLGNSYKYTMSKCVEAELQKSTIKNCGCMNSNWPRPVKPSQNIPYC--TNFSCSTDEILKRYEC-SSIKDQGLTKQKLVDTK-CFGVCSYFTYDTKVSVTNWKPSLYKLNRVTQIYK-LANENYTETDEGKTERVKKLKEKPQDT------------ISKNL--NMLTDESRFTYINVVRKNFDTIKKTERLVIDASIFMSRVGGLCSLLVGLTTAVFAELIEFCY 586 The following BLAST results are available for this feature:
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 3
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 3
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30031176 ID=SMED30031176|Name=FMRFamide-activated amiloride-sensitive sodium channel|organism=Schmidtea mediterranea sexual|type=transcript|length=1764bpback to top protein sequence of SMED30031176-orf-1 >SMED30031176-orf-1 ID=SMED30031176-orf-1|Name=SMED30031176-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=556bp MIELSENSKSKTKLFFQTFSIRGVSKIHHAKSQFEKTLWISFVIIMTFILback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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