Protein kinase domain-containing protein

Overview
NameProtein kinase domain-containing protein
Smed IDSMED30031142
Length (bp)2222
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Protein kinase domain-containing protein (SMED30031142) t-SNE clustered cells

Violin plots show distribution of expression levels for Protein kinase domain-containing protein (SMED30031142) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Protein kinase domain-containing protein (SMED30031142) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Protein kinase domain-containing protein (SMED30031142) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30031142

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 8

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
pharynxSMED30031142h1SMcG0012840 dd_Smed_v4_12680_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30031142h1SMcG0012840 dd_Smed_v4_12680_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30031142h1SMcG0012840 dd_Smed_v4_12680_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30031142h1SMcG0012840 dd_Smed_v4_12680_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30031142h1SMcG0012840 dd_Smed_v4_12680_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30031142h1SMcG0012840 dd_Smed_v4_12680_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30031142h1SMcG0012840 dd_Smed_v4_12680_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30031142h1SMcG0012840 dd_Smed_v4_12680_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: CHEK1 (checkpoint kinase 1 [Source:HGNC Symbol;Acc:HGNC:1925])

HSP 1 Score: 110.153 bits (274), Expect = 9.333e-27
Identity = 64/205 (31.22%), Postives = 114/205 (55.61%), Query Frame = 3 
Query: 1305 IENINITRELASGGFGKIFICQNKFSTNNFLIK-----KSINETENLHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPY-SNKIDIWSFGMVIVEMVTGK 1901
            +E+ ++ + L  G +G++ +  N+ +     +K     ++++  EN+ +EI IN +    + + K  G  R  N  YL + Y  GG L   IE    + E +     +Q++  +  LH +GI HRDIKP+N++ DE+ N K+ DFGLA     + N+++L N    + GT+ Y+APEL+K   + +  +D+WS G+V+  M+ G+
Sbjct:    6 VEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICIN-KMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVF-RYNNRERLLN---KMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGE 205
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: PNCK (pregnancy up-regulated nonubiquitous CaM kinase [Source:HGNC Symbol;Acc:HGNC:13415])

HSP 1 Score: 110.538 bits (275), Expect = 1.216e-25
Identity = 81/287 (28.22%), Postives = 145/287 (50.52%), Query Frame = 3 
Query: 1281 LMFERMRNIENINITRE-LASGGFGKIFICQNKFSTNNFLIK----KSINETENL-HREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFD---EKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSI--KQISNDMKLLIGSCLKANPELRQTGQQMIKSQLFINSFGRFNR 2108
            L+ +   +I ++   RE L SG F ++ + Q + S +   +K    K++   E L   EI +  +  + + +  +  +  + +H YLAM    GG L   I +     EK+  +++ Q+L  ++ LH LGI+HRD+KP+N+++    E     + DFGL+K         Q  N+     GT  Y+APEL++  PY   +D+W+ G++   ++ G PPF   +  ++  ++ +  +Y F S     IS   K  I   L+ +P+ R T QQ ++  L+I+    F+R
Sbjct:    3 LLKKHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISHPN-IVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKI--------QAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILR-ASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALR-HLWISGDTAFDR 278
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: PNCK (pregnancy up-regulated nonubiquitous CaM kinase [Source:HGNC Symbol;Acc:HGNC:13415])

HSP 1 Score: 110.538 bits (275), Expect = 1.216e-25
Identity = 81/287 (28.22%), Postives = 145/287 (50.52%), Query Frame = 3 
Query: 1281 LMFERMRNIENINITRE-LASGGFGKIFICQNKFSTNNFLIK----KSINETENL-HREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFD---EKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSI--KQISNDMKLLIGSCLKANPELRQTGQQMIKSQLFINSFGRFNR 2108
            L+ +   +I ++   RE L SG F ++ + Q + S +   +K    K++   E L   EI +  +  + + +  +  +  + +H YLAM    GG L   I +     EK+  +++ Q+L  ++ LH LGI+HRD+KP+N+++    E     + DFGL+K         Q  N+     GT  Y+APEL++  PY   +D+W+ G++   ++ G PPF   +  ++  ++ +  +Y F S     IS   K  I   L+ +P+ R T QQ ++  L+I+    F+R
Sbjct:    3 LLKKHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISHPN-IVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKI--------QAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILR-ASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALR-HLWISGDTAFDR 278
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: CHEK1 (checkpoint kinase 1 [Source:HGNC Symbol;Acc:HGNC:1925])

HSP 1 Score: 112.079 bits (279), Expect = 1.635e-25
Identity = 65/208 (31.25%), Postives = 116/208 (55.77%), Query Frame = 3 
Query: 1305 IENINITRELASGGFGKIFICQNKFSTNNFLIK-----KSINETENLHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPY-SNKIDIWSFGMVIVEMVTGKPPF 1910
            +E+ ++ + L  G +G++ +  N+ +     +K     ++++  EN+ +EI IN +    + + K  G  R  N  YL + Y  GG L   IE    + E +     +Q++  +  LH +GI HRDIKP+N++ DE+ N K+ DFGLA     + N+++L N    + GT+ Y+APEL+K   + +  +D+WS G+V+  M+ G+ P+
Sbjct:    6 VEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICIN-KMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVF-RYNNRERLLN---KMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPW 208
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: CHEK1 (checkpoint kinase 1 [Source:HGNC Symbol;Acc:HGNC:1925])

HSP 1 Score: 112.079 bits (279), Expect = 1.815e-25
Identity = 65/208 (31.25%), Postives = 116/208 (55.77%), Query Frame = 3 
Query: 1305 IENINITRELASGGFGKIFICQNKFSTNNFLIK-----KSINETENLHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPY-SNKIDIWSFGMVIVEMVTGKPPF 1910
            +E+ ++ + L  G +G++ +  N+ +     +K     ++++  EN+ +EI IN +    + + K  G  R  N  YL + Y  GG L   IE    + E +     +Q++  +  LH +GI HRDIKP+N++ DE+ N K+ DFGLA     + N+++L N    + GT+ Y+APEL+K   + +  +D+WS G+V+  M+ G+ P+
Sbjct:    6 VEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICIN-KMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVF-RYNNRERLLN---KMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPW 208
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: unc-82 (pep chromosome:WBcel235:IV:7424498:7444660:1 gene:WBGene00006814.1 transcript:B0496.3e.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:unc-82)

HSP 1 Score: 114.39 bits (285), Expect = 1.124e-25
Identity = 76/252 (30.16%), Postives = 130/252 (51.59%), Query Frame = 3 
Query: 1320 ITRELASGGFGKIFIC-QNKFSTNNF--LIKKSINETE----NLHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSN-KIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELRQT 2051
            IT++L SG +GK+ +   +KF       LIKKS  E++     + REI I S   + + + +I  +  N++   L M Y  GG L  Y+ +   L E E   I  QI   +   H+  + HRD+K +NI+ D+  NAK+ DFGL+    +       +NL +   G+  Y +PE++ G+PY   ++D WS G+++  +V G  PF G    +++ ++++   +      +  +   +LI + L+ NPE R T
Sbjct:  299 ITKKLGSGTYGKVSLAYDHKFDREVAVKLIKKSAIESKADLVRIRREIRIMSALNHPN-IIQIYEVFENKDKIILVMEYSSGGELYDYVSRCGSLPEAEARRIFRQITSAVLYCHKHRVAHRDLKLENILLDQNNNAKIADFGLSNYFAD-------KNLLTTFCGSPLYASPEIINGTPYKGPEVDCWSLGILLYTLVYGSMPFDGRDFNRMVRQIKRGAYFE----PETPSTASMLIRNMLRVNPERRAT 538
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: unc-82 (pep chromosome:WBcel235:IV:7428926:7444648:1 gene:WBGene00006814.1 transcript:B0496.3b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:unc-82)

HSP 1 Score: 114.005 bits (284), Expect = 1.474e-25
Identity = 76/252 (30.16%), Postives = 130/252 (51.59%), Query Frame = 3 
Query: 1320 ITRELASGGFGKIFIC-QNKFSTNNF--LIKKSINETE----NLHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSN-KIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELRQT 2051
            IT++L SG +GK+ +   +KF       LIKKS  E++     + REI I S   + + + +I  +  N++   L M Y  GG L  Y+ +   L E E   I  QI   +   H+  + HRD+K +NI+ D+  NAK+ DFGL+    +       +NL +   G+  Y +PE++ G+PY   ++D WS G+++  +V G  PF G    +++ ++++   +      +  +   +LI + L+ NPE R T
Sbjct:   60 ITKKLGSGTYGKVSLAYDHKFDREVAVKLIKKSAIESKADLVRIRREIRIMSALNHPN-IIQIYEVFENKDKIILVMEYSSGGELYDYVSRCGSLPEAEARRIFRQITSAVLYCHKHRVAHRDLKLENILLDQNNNAKIADFGLSNYFAD-------KNLLTTFCGSPLYASPEIINGTPYKGPEVDCWSLGILLYTLVYGSMPFDGRDFNRMVRQIKRGAYFE----PETPSTASMLIRNMLRVNPERRAT 299
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: unc-82 (pep chromosome:WBcel235:IV:7428926:7444648:1 gene:WBGene00006814.1 transcript:B0496.3d.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:unc-82)

HSP 1 Score: 114.005 bits (284), Expect = 1.490e-25
Identity = 76/252 (30.16%), Postives = 130/252 (51.59%), Query Frame = 3 
Query: 1320 ITRELASGGFGKIFIC-QNKFSTNNF--LIKKSINETE----NLHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSN-KIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELRQT 2051
            IT++L SG +GK+ +   +KF       LIKKS  E++     + REI I S   + + + +I  +  N++   L M Y  GG L  Y+ +   L E E   I  QI   +   H+  + HRD+K +NI+ D+  NAK+ DFGL+    +       +NL +   G+  Y +PE++ G+PY   ++D WS G+++  +V G  PF G    +++ ++++   +      +  +   +LI + L+ NPE R T
Sbjct:   60 ITKKLGSGTYGKVSLAYDHKFDREVAVKLIKKSAIESKADLVRIRREIRIMSALNHPN-IIQIYEVFENKDKIILVMEYSSGGELYDYVSRCGSLPEAEARRIFRQITSAVLYCHKHRVAHRDLKLENILLDQNNNAKIADFGLSNYFAD-------KNLLTTFCGSPLYASPEIINGTPYKGPEVDCWSLGILLYTLVYGSMPFDGRDFNRMVRQIKRGAYFE----PETPSTASMLIRNMLRVNPERRAT 299
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: unc-82 (pep chromosome:WBcel235:IV:7428926:7444648:1 gene:WBGene00006814.1 transcript:B0496.3f.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:unc-82)

HSP 1 Score: 113.62 bits (283), Expect = 1.766e-25
Identity = 76/252 (30.16%), Postives = 130/252 (51.59%), Query Frame = 3 
Query: 1320 ITRELASGGFGKIFIC-QNKFSTNNF--LIKKSINETE----NLHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSN-KIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELRQT 2051
            IT++L SG +GK+ +   +KF       LIKKS  E++     + REI I S   + + + +I  +  N++   L M Y  GG L  Y+ +   L E E   I  QI   +   H+  + HRD+K +NI+ D+  NAK+ DFGL+    +       +NL +   G+  Y +PE++ G+PY   ++D WS G+++  +V G  PF G    +++ ++++   +      +  +   +LI + L+ NPE R T
Sbjct:   60 ITKKLGSGTYGKVSLAYDHKFDREVAVKLIKKSAIESKADLVRIRREIRIMSALNHPN-IIQIYEVFENKDKIILVMEYSSGGELYDYVSRCGSLPEAEARRIFRQITSAVLYCHKHRVAHRDLKLENILLDQNNNAKIADFGLSNYFAD-------KNLLTTFCGSPLYASPEIINGTPYKGPEVDCWSLGILLYTLVYGSMPFDGRDFNRMVRQIKRGAYFE----PETPSTASMLIRNMLRVNPERRAT 299
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: unc-82 (pep chromosome:WBcel235:IV:7431348:7444648:1 gene:WBGene00006814.1 transcript:B0496.3i.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:unc-82)

HSP 1 Score: 113.62 bits (283), Expect = 1.901e-25
Identity = 76/252 (30.16%), Postives = 130/252 (51.59%), Query Frame = 3 
Query: 1320 ITRELASGGFGKIFIC-QNKFSTNNF--LIKKSINETE----NLHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSN-KIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELRQT 2051
            IT++L SG +GK+ +   +KF       LIKKS  E++     + REI I S   + + + +I  +  N++   L M Y  GG L  Y+ +   L E E   I  QI   +   H+  + HRD+K +NI+ D+  NAK+ DFGL+    +       +NL +   G+  Y +PE++ G+PY   ++D WS G+++  +V G  PF G    +++ ++++   +      +  +   +LI + L+ NPE R T
Sbjct:   77 ITKKLGSGTYGKVSLAYDHKFDREVAVKLIKKSAIESKADLVRIRREIRIMSALNHPN-IIQIYEVFENKDKIILVMEYSSGGELYDYVSRCGSLPEAEARRIFRQITSAVLYCHKHRVAHRDLKLENILLDQNNNAKIADFGLSNYFAD-------KNLLTTFCGSPLYASPEIINGTPYKGPEVDCWSLGILLYTLVYGSMPFDGRDFNRMVRQIKRGAYFE----PETPSTASMLIRNMLRVNPERRAT 316
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: PhKgamma (gene:FBgn0011754 transcript:FBtr0343587)

HSP 1 Score: 110.923 bits (276), Expect = 8.126e-26
Identity = 79/242 (32.64%), Postives = 122/242 (50.41%), Query Frame = 3 
Query: 1422 ENLHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVK-----GSP-YSNKIDIWSFGMVIVEMVTGKPPF---PGMAIGKILLELRKLETYRFKSIK--QISNDMKLLIGSCLKANPELRQTGQQMIKSQLF---INSFGRFN 2105
            E   +EI I  Q      +  +  +  ++   +L     P G L  Y+  V  L EK+   I+ QI   +  +H   I+HRD+KP+NI+ DE  N K+ DFG AK + E    ++L NL     GT  Y+APE +K     GSP YS ++DIW+ G+++  ++ G PPF     M + + ++E +    Y F S +   IS D K LI  CL  +P  R T +++++   F   +    RFN
Sbjct:   72 EATRQEISILRQVMGHPYIIDLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLSEKKTRTIMRQIFEGVEYIHAKSIVHRDLKPENILLDENHNVKITDFGFAKQLQE---GEKLTNL----CGTPGYLAPETLKCNMFEGSPGYSQEVDIWACGVIMFTLLVGCPPFWHRKQMVMLRNIMEGK----YSFTSPEWADISEDPKDLIRKCLVVDPSQRITVKEVLRHPFFNQMLRKQSRFN 302
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: PhKgamma (gene:FBgn0011754 transcript:FBtr0090002)

HSP 1 Score: 110.538 bits (275), Expect = 1.947e-25
Identity = 76/231 (32.90%), Postives = 118/231 (51.08%), Query Frame = 3 
Query: 1422 ENLHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVK-----GSP-YSNKIDIWSFGMVIVEMVTGKPPF---PGMAIGKILLELRKLETYRFKSIK--QISNDMKLLIGSCLKANPELRQTGQQMIKSQLF 2081
            E   +EI I  Q      +  +  +  ++   +L     P G L  Y+  V  L EK+   I+ QI   +  +H   I+HRD+KP+NI+ DE  N K+ DFG AK + E    ++L NL     GT  Y+APE +K     GSP YS ++DIW+ G+++  ++ G PPF     M + + ++E +    Y F S +   IS D K LI  CL  +P  R T +++++   F
Sbjct:   72 EATRQEISILRQVMGHPYIIDLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLSEKKTRTIMRQIFEGVEYIHAKSIVHRDLKPENILLDENHNVKITDFGFAKQLQE---GEKLTNL----CGTPGYLAPETLKCNMFEGSPGYSQEVDIWACGVIMFTLLVGCPPFWHRKQMVMLRNIMEGK----YSFTSPEWADISEDPKDLIRKCLVVDPSQRITVKEVLRHPFF 291
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: PhKgamma (gene:FBgn0011754 transcript:FBtr0343648)

HSP 1 Score: 110.538 bits (275), Expect = 1.947e-25
Identity = 76/231 (32.90%), Postives = 118/231 (51.08%), Query Frame = 3 
Query: 1422 ENLHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVK-----GSP-YSNKIDIWSFGMVIVEMVTGKPPF---PGMAIGKILLELRKLETYRFKSIK--QISNDMKLLIGSCLKANPELRQTGQQMIKSQLF 2081
            E   +EI I  Q      +  +  +  ++   +L     P G L  Y+  V  L EK+   I+ QI   +  +H   I+HRD+KP+NI+ DE  N K+ DFG AK + E    ++L NL     GT  Y+APE +K     GSP YS ++DIW+ G+++  ++ G PPF     M + + ++E +    Y F S +   IS D K LI  CL  +P  R T +++++   F
Sbjct:   72 EATRQEISILRQVMGHPYIIDLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLSEKKTRTIMRQIFEGVEYIHAKSIVHRDLKPENILLDENHNVKITDFGFAKQLQE---GEKLTNL----CGTPGYLAPETLKCNMFEGSPGYSQEVDIWACGVIMFTLLVGCPPFWHRKQMVMLRNIMEGK----YSFTSPEWADISEDPKDLIRKCLVVDPSQRITVKEVLRHPFF 291
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: PhKgamma (gene:FBgn0011754 transcript:FBtr0301501)

HSP 1 Score: 110.153 bits (274), Expect = 8.163e-25
Identity = 76/231 (32.90%), Postives = 118/231 (51.08%), Query Frame = 3 
Query: 1422 ENLHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVK-----GSP-YSNKIDIWSFGMVIVEMVTGKPPF---PGMAIGKILLELRKLETYRFKSIK--QISNDMKLLIGSCLKANPELRQTGQQMIKSQLF 2081
            E   +EI I  Q      +  +  +  ++   +L     P G L  Y+  V  L EK+   I+ QI   +  +H   I+HRD+KP+NI+ DE  N K+ DFG AK + E    ++L NL     GT  Y+APE +K     GSP YS ++DIW+ G+++  ++ G PPF     M + + ++E +    Y F S +   IS D K LI  CL  +P  R T +++++   F
Sbjct:   72 EATRQEISILRQVMGHPYIIDLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLSEKKTRTIMRQIFEGVEYIHAKSIVHRDLKPENILLDENHNVKITDFGFAKQLQE---GEKLTNLC----GTPGYLAPETLKCNMFEGSPGYSQEVDIWACGVIMFTLLVGCPPFWHRKQMVMLRNIMEGK----YSFTSPEWADISEDPKDLIRKCLVVDPSQRITVKEVLRHPFF 291
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: PhKgamma (gene:FBgn0011754 transcript:FBtr0301500)

HSP 1 Score: 110.153 bits (274), Expect = 8.163e-25
Identity = 76/231 (32.90%), Postives = 118/231 (51.08%), Query Frame = 3 
Query: 1422 ENLHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVK-----GSP-YSNKIDIWSFGMVIVEMVTGKPPF---PGMAIGKILLELRKLETYRFKSIK--QISNDMKLLIGSCLKANPELRQTGQQMIKSQLF 2081
            E   +EI I  Q      +  +  +  ++   +L     P G L  Y+  V  L EK+   I+ QI   +  +H   I+HRD+KP+NI+ DE  N K+ DFG AK + E    ++L NL     GT  Y+APE +K     GSP YS ++DIW+ G+++  ++ G PPF     M + + ++E +    Y F S +   IS D K LI  CL  +P  R T +++++   F
Sbjct:   72 EATRQEISILRQVMGHPYIIDLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLSEKKTRTIMRQIFEGVEYIHAKSIVHRDLKPENILLDENHNVKITDFGFAKQLQE---GEKLTNLC----GTPGYLAPETLKCNMFEGSPGYSQEVDIWACGVIMFTLLVGCPPFWHRKQMVMLRNIMEGK----YSFTSPEWADISEDPKDLIRKCLVVDPSQRITVKEVLRHPFF 291
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: camk1a (calcium/calmodulin-dependent protein kinase Ia [Source:ZFIN;Acc:ZDB-GENE-131120-147])

HSP 1 Score: 114.775 bits (286), Expect = 4.507e-27
Identity = 77/263 (29.28%), Postives = 132/263 (50.19%), Query Frame = 3 
Query: 1308 ENINITRELASGGFGKIFICQNKFSTNNFLIK----KSINETEN-LHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVF---DEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSI--KQISNDMKLLIGSCLKANPELRQTGQQMI 2066
            EN +    L +G F ++F+ + K +     IK    K++   EN +  EI +  +  + + +  +  +  +++H YL M    GG L   I +     E++   ++ QIL  +  LH +GI+HRD+KP+N+++   +E  N  + DFGL+K  D         ++ S   GT  Y+APE++   PYS  +D WS G++   ++ G PPF      K+  ++ K E Y F S     IS+  K  I   ++ +P LR T +Q +
Sbjct:   19 ENYDFKEVLGTGAFSEVFLAEEKKTQRLVAIKCIPKKALEGKENSIENEIAVLHRIKH-ENIVSLEDIFESQSHLYLVMQLVSGGELFDRIVEKGFYTERDASKLIRQILDAVKYLHDMGIVHRDLKPENLLYYSMEEDSNIMISDFGLSKIEDSG-------SVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVISYILLCGYPPFYDENDAKLFEQILKAE-YEFDSPYWDDISDSAKDFISHLMEKDPSLRYTCEQAL 272
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: camk1a (calcium/calmodulin-dependent protein kinase Ia [Source:ZFIN;Acc:ZDB-GENE-131120-147])

HSP 1 Score: 115.161 bits (287), Expect = 4.652e-27
Identity = 77/263 (29.28%), Postives = 132/263 (50.19%), Query Frame = 3 
Query: 1308 ENINITRELASGGFGKIFICQNKFSTNNFLIK----KSINETEN-LHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVF---DEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSI--KQISNDMKLLIGSCLKANPELRQTGQQMI 2066
            EN +    L +G F ++F+ + K +     IK    K++   EN +  EI +  +  + + +  +  +  +++H YL M    GG L   I +     E++   ++ QIL  +  LH +GI+HRD+KP+N+++   +E  N  + DFGL+K  D         ++ S   GT  Y+APE++   PYS  +D WS G++   ++ G PPF      K+  ++ K E Y F S     IS+  K  I   ++ +P LR T +Q +
Sbjct:   19 ENYDFKEVLGTGAFSEVFLAEEKKTQRLVAIKCIPKKALEGKENSIENEIAVLHRIKH-ENIVSLEDIFESQSHLYLVMQLVSGGELFDRIVEKGFYTERDASKLIRQILDAVKYLHDMGIVHRDLKPENLLYYSMEEDSNIMISDFGLSKIEDSG-------SVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVISYILLCGYPPFYDENDAKLFEQILKAE-YEFDSPYWDDISDSAKDFISHLMEKDPSLRYTCEQAL 272
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: camk1a (calcium/calmodulin-dependent protein kinase Ia [Source:ZFIN;Acc:ZDB-GENE-131120-147])

HSP 1 Score: 115.161 bits (287), Expect = 4.652e-27
Identity = 77/263 (29.28%), Postives = 132/263 (50.19%), Query Frame = 3 
Query: 1308 ENINITRELASGGFGKIFICQNKFSTNNFLIK----KSINETEN-LHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVF---DEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSI--KQISNDMKLLIGSCLKANPELRQTGQQMI 2066
            EN +    L +G F ++F+ + K +     IK    K++   EN +  EI +  +  + + +  +  +  +++H YL M    GG L   I +     E++   ++ QIL  +  LH +GI+HRD+KP+N+++   +E  N  + DFGL+K  D         ++ S   GT  Y+APE++   PYS  +D WS G++   ++ G PPF      K+  ++ K E Y F S     IS+  K  I   ++ +P LR T +Q +
Sbjct:   19 ENYDFKEVLGTGAFSEVFLAEEKKTQRLVAIKCIPKKALEGKENSIENEIAVLHRIKH-ENIVSLEDIFESQSHLYLVMQLVSGGELFDRIVEKGFYTERDASKLIRQILDAVKYLHDMGIVHRDLKPENLLYYSMEEDSNIMISDFGLSKIEDSG-------SVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVISYILLCGYPPFYDENDAKLFEQILKAE-YEFDSPYWDDISDSAKDFISHLMEKDPSLRYTCEQAL 272
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: stk24a (serine/threonine kinase 24a (STE20 homolog, yeast) [Source:ZFIN;Acc:ZDB-GENE-070424-52])

HSP 1 Score: 110.923 bits (276), Expect = 1.653e-25
Identity = 77/258 (29.84%), Postives = 129/258 (50.00%), Query Frame = 3 
Query: 1332 LASGGFGKIFICQNKFSTNNFLIK-----KSINETENLHREIFINSQFFYSDKLF--KISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELRQTGQQMIKSQLFI 2084
            +  G FG++F   +  +     IK     ++ +E E++ +EI + SQ    D LF  K  G    +   ++ M Y  GGS    +     LDE  I  IL +IL  ++ LH    IHRDIK  N++  E+ + KL DFG+A  + + + K      ++   GT  +MAPE++K S Y +K DIWS G+  +E+  G+PP   +   K+L  + K      +     +  +K  + +CL  +P  R T ++++K +L +
Sbjct:   23 IGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEVEDIQQEITVLSQ---CDSLFITKYFGSYLKDTKLWIIMEYLGGGSALDLLGP-GALDETHIATILREILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIK------RNTFVGTPFWMAPEVIKQSEYDSKADIWSLGITAIELAKGEPPHSDLHPMKVLFLIPKENPPTLEG--NYNKALKEFVDACLNKDPNFRPTAKELLKHKLIV 268
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: hunk (hormonally up-regulated Neu-associated kinase [Source:ZFIN;Acc:ZDB-GENE-050309-240])

HSP 1 Score: 106.686 bits (265), Expect = 4.988e-25
Identity = 59/163 (36.20%), Postives = 90/163 (55.21%), Query Frame = 3 
Query: 1422 ENLHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPF 1910
            +NL RE  I  Q      + ++  ++  EN  YL M   PGG+L +YI + + L+E+E    + Q++M +  LHR G++HRD+K +N++ D+  N KLIDFGL+         D      S   G+  Y APEL+    Y  K+D+WS G+ +  M+TG  PF
Sbjct:   93 KNLRREGNI-QQMIRHPHIAQLLDIMETENRFYLVMELCPGGNLMNYIYENKRLEEREANKYVRQLVMAVEHLHRAGVVHRDLKIENLLLDDHDNLKLIDFGLSNSAGILGYSDPF----STQCGSPAYAAPELLSRKKYGPKVDVWSIGVNMYAMLTGTLPF 250
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: numbl (numb homolog-like [Source:Xenbase;Acc:XB-GENE-961776])

HSP 1 Score: 107.842 bits (268), Expect = 7.565e-25
Identity = 76/273 (27.84%), Postives = 137/273 (50.18%), Query Frame = 3 
Query: 1302 NIENINITRELASGGFGKIFICQNKFSTNNFLIKK-------SINETENLHREIFINSQFFYSDKLFKIS--GLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELR----QTGQQMIKSQLF 2081
            ++EN N+ + L  G FGK+F+ + K +     IK        + N+ +++ +E  I  +   ++  F +S     ++ENH +  M Y PGG L   +E     +E +       I++ + ELHR  I+HRD+K +N++ D     K++DFGL+K  D ++  D+ + L     GT  YMAPE++    YS  +D W+ G+V+  M+  + PF      ++   +R     +    +++S + + LI   L+ NP  R    + G + +K+  F
Sbjct:   16 SLENFNLGKVLGEGTFGKVFLAEYKDTKQLCAIKTLKKERIIAKNDIKSVFKEKRILQKVTSAEHPFLVSLYATFQSENHLFFVMEYLPGGDLCHLLEHQGAFEESKAMFYTACIVLGLEELHRNNIVHRDLKLENLMVDVHGYLKIVDFGLSK--DGFRYGDRSKTL----CGTNCYMAPEIIDEMAYSRAVDWWALGVVLYVMIMFQFPFDAEDDMELFESIR---NDKPALTEELSEEAQCLILRLLEKNPCRRLGYSEAGAEEVKAHEF 279
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: bnc2 (basonuclin 2 [Source:Xenbase;Acc:XB-GENE-953157])

HSP 1 Score: 108.227 bits (269), Expect = 3.097e-24
Identity = 61/208 (29.33%), Postives = 113/208 (54.33%), Query Frame = 3 
Query: 1305 IENINITRELASGGFGKIFICQNKFSTNNFLIK-----KSINETENLHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPY-SNKIDIWSFGMVIVEMVTGKPPF 1910
            +E+ ++ + L  G +G++ +  N+ +     +K     ++ +  EN+ +EI IN    +++ + +  G  R  N  YL + Y  GG L   IE    + E++      Q++  +  LH +GI HRDIKP+N++ D++ + K+ DFGLA         +  E L + + GT+ Y+APEL+K   + +  +D+WS G+V+  M+ G+ P+
Sbjct:    6 VEDWDLVQTLGEGAYGEVQLAVNRKTEEAVAVKIVDMTRAADCPENIKKEICINRMLNHTN-IVRFYGHRREGNIQYLFLEYCRGGELFDRIEPDVGMPEQDAQKFFQQLIAGVEYLHSIGITHRDIKPENLLLDDRDHLKISDFGLATVF----RHNAKERLLNKMCGTLPYVAPELIKSRAFNAEPVDVWSCGIVLTAMLAGELPW 208
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: exosc4 (exosome component 4 [Source:Xenbase;Acc:XB-GENE-969649])

HSP 1 Score: 105.145 bits (261), Expect = 6.309e-24
Identity = 77/271 (28.41%), Postives = 131/271 (48.34%), Query Frame = 3 
Query: 1299 RNIENIN----ITRELASGGFGKIFICQNKFSTNNFLIK----KSINETENL-HREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFD---EKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSI--KQISNDMKLLIGSCLKANPELRQTGQQMIK 2069
            + IE+IN    I  +L +G F ++ + Q K S     +K    K++   E +   EI +  +  + + +  +  +  +  H YLAM    GG L   I +     EK+   ++ Q+L  +  LH +GI+HRD+KP+N+++    E     + DFGL+K  D          + +   GT  Y+APEL++  PY   +D+W+ G++   ++ G PPF      ++  ++ K E Y F S     IS   K  I   L+  PE R T +Q ++
Sbjct:    9 KKIEDINMAYNIKEKLGAGAFSEVVLAQEKNSERLVALKCIPKKALRGKEAVVENEIAVLKKITHKN-IVSLEDIYESPTHLYLAMELVTGGELFDRIIERGYYTEKDASQLIRQVLDAVQYLHNMGIVHRDLKPENLLYATPFEDSKIMISDFGLSKIED--------GGMMATACGTPGYVAPELLEQKPYGKAVDVWAIGVISYILLCGYPPFYDENDSELFNQILKAE-YEFDSPYWDDISESAKDFIRHLLEREPEKRLTCEQALQ 269
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: stk10 (serine/threonine kinase 10 [Source:NCBI gene;Acc:780079])

HSP 1 Score: 108.997 bits (271), Expect = 6.564e-24
Identity = 82/265 (30.94%), Postives = 131/265 (49.43%), Query Frame = 3 
Query: 1317 NITRELASGGFGKIFICQNK----FSTNNFLIKKSINETENLHREIFI----NSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSL-ASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELV-----KGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELRQTGQQMIK 2069
             I  EL  G FGK++  +NK     +    +  K+  E E+   EI I    N  F     + K+ G    E   ++ + + PGG++ A  +E  R L E EI  I  Q+L  +  LH + +IHRD+K  N++     + KL DFG++      KN   L+   S++ GT  +MAPE+V     K +PY  K DIWS G+ ++EM   +PP   +   ++LL++ K E     S  + S +    + + L  NPE R +  Q+++
Sbjct:   37 EIIGELGDGAFGKVYKAKNKETGILAAAKVIETKNEEELEDYMVEIEILATCNHHF-----IVKLLGSYYWEGKLWIMIEFCPGGAVDAIMLELDRGLKEPEIRTICRQMLEGLTYLHSMKMIHRDLKAGNVLLTLDGDIKLADFGVSA-----KNVKTLQRRDSFI-GTPYWMAPEVVMCETMKDAPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSEPPTLSSPSKWSPEFHNFLKTALDKNPETRPSAAQLLE 290
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: stk10 (serine/threonine kinase 10 [Source:NCBI gene;Acc:780079])

HSP 1 Score: 108.997 bits (271), Expect = 7.772e-24
Identity = 82/264 (31.06%), Postives = 131/264 (49.62%), Query Frame = 3 
Query: 1320 ITRELASGGFGKIFICQNK----FSTNNFLIKKSINETENLHREIFI----NSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSL-ASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELV-----KGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELRQTGQQMIK 2069
            I  EL  G FGK++  +NK     +    +  K+  E E+   EI I    N  F     + K+ G    E   ++ + + PGG++ A  +E  R L E EI  I  Q+L  +  LH + +IHRD+K  N++     + KL DFG++      KN   L+   S++ GT  +MAPE+V     K +PY  K DIWS G+ ++EM   +PP   +   ++LL++ K E     S  + S +    + + L  NPE R +  Q+++
Sbjct:   38 IIGELGDGAFGKVYKAKNKETGILAAAKVIETKNEEELEDYMVEIEILATCNHHF-----IVKLLGSYYWEGKLWIMIEFCPGGAVDAIMLELDRGLKEPEIRTICRQMLEGLTYLHSMKMIHRDLKAGNVLLTLDGDIKLADFGVSA-----KNVKTLQRRDSFI-GTPYWMAPEVVMCETMKDAPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSEPPTLSSPSKWSPEFHNFLKTALDKNPETRPSAAQLLE 290
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Gm4922 (predicted gene 4922 [Source:MGI Symbol;Acc:MGI:3644318])

HSP 1 Score: 116.701 bits (291), Expect = 5.657e-27
Identity = 77/264 (29.17%), Postives = 129/264 (48.86%), Query Frame = 3 
Query: 1284 MFERMRNIENINITRELASGGFGKIFICQNKFSTNNFLIK--KSINETENLHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSN-KIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELRQTGQQMI 2066
            MFE         + + L+  G  ++ +C +  +     +K  K     E    E+ I     + + +  +  +I  E + YL M    G  L + +++ RCL E E  +I  Q+L  I   H  G++HRD+KPDN++ DE  N K++DFGL      +    +LE L     G  +++ PE+  G PY   K+DIW+ G+++  MVTG  PF G  + +I  E+ +    R++    +S D++ +IG  L  N   R T Q ++
Sbjct:   18 MFEEKEFTRQYTVLKTLSQHGTTEVRLCSHHLTGVTVAVKALKYQRWWEPKVSEVEIMKMLSHPN-IVSLLQVIETEQNIYLIMEVAQGTQLHNRVQEARCLKEDEARSIFVQLLSAIGYCHGEGVVHRDLKPDNVIVDEHGNVKIVDFGLGA---RFMPGQKLERLC----GAFQFIPPEIFLGLPYDGPKVDIWALGVLLYYMVTGIFPFVGSTLSEISKEVLQ---GRYEIPYNLSKDLRSMIGLLLATNARQRPTAQDLL 270
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Gm4922 (predicted gene 4922 [Source:MGI Symbol;Acc:MGI:3644318])

HSP 1 Score: 116.701 bits (291), Expect = 5.657e-27
Identity = 77/264 (29.17%), Postives = 129/264 (48.86%), Query Frame = 3 
Query: 1284 MFERMRNIENINITRELASGGFGKIFICQNKFSTNNFLIK--KSINETENLHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSN-KIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELRQTGQQMI 2066
            MFE         + + L+  G  ++ +C +  +     +K  K     E    E+ I     + + +  +  +I  E + YL M    G  L + +++ RCL E E  +I  Q+L  I   H  G++HRD+KPDN++ DE  N K++DFGL      +    +LE L     G  +++ PE+  G PY   K+DIW+ G+++  MVTG  PF G  + +I  E+ +    R++    +S D++ +IG  L  N   R T Q ++
Sbjct:   18 MFEEKEFTRQYTVLKTLSQHGTTEVRLCSHHLTGVTVAVKALKYQRWWEPKVSEVEIMKMLSHPN-IVSLLQVIETEQNIYLIMEVAQGTQLHNRVQEARCLKEDEARSIFVQLLSAIGYCHGEGVVHRDLKPDNVIVDEHGNVKIVDFGLGA---RFMPGQKLERLC----GAFQFIPPEIFLGLPYDGPKVDIWALGVLLYYMVTGIFPFVGSTLSEISKEVLQ---GRYEIPYNLSKDLRSMIGLLLATNARQRPTAQDLL 270
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Pnck (pregnancy upregulated non-ubiquitously expressed CaM kinase [Source:MGI Symbol;Acc:MGI:1347357])

HSP 1 Score: 112.079 bits (279), Expect = 2.417e-26
Identity = 81/287 (28.22%), Postives = 146/287 (50.87%), Query Frame = 3 
Query: 1281 LMFERMRNIENINITRE-LASGGFGKIFICQNKFSTNNFLIK----KSINETENL-HREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFD---EKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSI--KQISNDMKLLIGSCLKANPELRQTGQQMIKSQLFINSFGRFNR 2108
            L+ ++  +I ++   RE L SG F ++ + Q + S +   +K    K++   E L   EI +  +  + + +  +  +  + +H YLAM    GG L   I +     EK+  +++ Q+L  ++ LH LGI+HRD+KP+N+++    E     + DFGL+K         Q  N+     GT  Y+APEL++  PY   +D+W+ G++   ++ G PPF   +  ++  ++ +  +Y F S     IS   K  I   L+ +P+ R T QQ ++  L+I+    F+R
Sbjct:    3 LLKKQTEDISSVYEIREKLGSGAFSEVMLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISHPN-IVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKI--------QAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILR-ASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALQ-HLWISGDAAFDR 278
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Pnck (pregnancy upregulated non-ubiquitously expressed CaM kinase [Source:MGI Symbol;Acc:MGI:1347357])

HSP 1 Score: 112.079 bits (279), Expect = 2.417e-26
Identity = 81/287 (28.22%), Postives = 146/287 (50.87%), Query Frame = 3 
Query: 1281 LMFERMRNIENINITRE-LASGGFGKIFICQNKFSTNNFLIK----KSINETENL-HREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFD---EKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSI--KQISNDMKLLIGSCLKANPELRQTGQQMIKSQLFINSFGRFNR 2108
            L+ ++  +I ++   RE L SG F ++ + Q + S +   +K    K++   E L   EI +  +  + + +  +  +  + +H YLAM    GG L   I +     EK+  +++ Q+L  ++ LH LGI+HRD+KP+N+++    E     + DFGL+K         Q  N+     GT  Y+APEL++  PY   +D+W+ G++   ++ G PPF   +  ++  ++ +  +Y F S     IS   K  I   L+ +P+ R T QQ ++  L+I+    F+R
Sbjct:    3 LLKKQTEDISSVYEIREKLGSGAFSEVMLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISHPN-IVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKI--------QAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILR-ASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALQ-HLWISGDAAFDR 278
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Pnck (pregnancy upregulated non-ubiquitously expressed CaM kinase [Source:MGI Symbol;Acc:MGI:1347357])

HSP 1 Score: 112.079 bits (279), Expect = 2.417e-26
Identity = 81/287 (28.22%), Postives = 146/287 (50.87%), Query Frame = 3 
Query: 1281 LMFERMRNIENINITRE-LASGGFGKIFICQNKFSTNNFLIK----KSINETENL-HREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFD---EKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSI--KQISNDMKLLIGSCLKANPELRQTGQQMIKSQLFINSFGRFNR 2108
            L+ ++  +I ++   RE L SG F ++ + Q + S +   +K    K++   E L   EI +  +  + + +  +  +  + +H YLAM    GG L   I +     EK+  +++ Q+L  ++ LH LGI+HRD+KP+N+++    E     + DFGL+K         Q  N+     GT  Y+APEL++  PY   +D+W+ G++   ++ G PPF   +  ++  ++ +  +Y F S     IS   K  I   L+ +P+ R T QQ ++  L+I+    F+R
Sbjct:    3 LLKKQTEDISSVYEIREKLGSGAFSEVMLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISHPN-IVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKI--------QAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILR-ASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALQ-HLWISGDAAFDR 278
[Close]
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q10056|SHK2_SCHPO (Serine/threonine-protein kinase shk2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=shk2 PE=3 SV=1)

HSP 1 Score: 117.857 bits (294), Expect = 3.463e-26
Identity = 76/270 (28.15%), Postives = 130/270 (48.15%), Query Frame = 3 
Query: 1305 IENINITRELASGGFGKIFICQ----NKFSTNNFLIKKSINETENLHREIFINS-----QFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELRQTGQQMIKSQLFIN 2087
            +E  N+  +L  G  G +++ +     +    + +  KSI+      +E+ +N      +  + + +  +   +  E H ++ M Y   GSL   IE+ + L E +I  I  +    I  LH   IIHRDIK DN++ D   N K+ DFG    +    NK      +  + GT  +MAPE+VK + Y  K+DIWS G++I+EM+  +PP+      + L  + K  T   K    +S ++K  + SCL  +   R T  +++ +  F+N
Sbjct:  306 VEYFNVKHKLGQGASGSVYLAKVVGGKQLGIFDSVAIKSIDLQCQTRKELILNEITVMRESIHPNIVTYLDSFLVRERHLWVVMEYMNAGSLTDIIEKSK-LTEAQIARICLETCKGIQHLHARNIIHRDIKSDNVLLDNSGNIKITDFGFCARLSNRTNK------RVTMVGTPYWMAPEVVKQNEYGTKVDIWSLGIMIIEMIENEPPYLREDPIRALYLIAKNGTPTLKKPNLVSKNLKSFLNSCLTIDTIFRATAAELL-THSFLN 567
[Close]
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q8C0N0|SMKZ_MOUSE (Sperm motility kinase Z OS=Mus musculus OX=10090 GN=Gm4922 PE=2 SV=1)

HSP 1 Score: 116.701 bits (291), Expect = 3.957e-26
Identity = 77/264 (29.17%), Postives = 129/264 (48.86%), Query Frame = 3 
Query: 1284 MFERMRNIENINITRELASGGFGKIFICQNKFSTNNFLIK--KSINETENLHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSN-KIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELRQTGQQMI 2066
            MFE         + + L+  G  ++ +C +  +     +K  K     E    E+ I     + + +  +  +I  E + YL M    G  L + +++ RCL E E  +I  Q+L  I   H  G++HRD+KPDN++ DE  N K++DFGL      +    +LE L     G  +++ PE+  G PY   K+DIW+ G+++  MVTG  PF G  + +I  E+ +    R++    +S D++ +IG  L  N   R T Q ++
Sbjct:   18 MFEEKEFTRQYTVLKTLSQHGTTEVRLCSHHLTGVTVAVKALKYQRWWEPKVSEVEIMKMLSHPN-IVSLLQVIETEQNIYLIMEVAQGTQLHNRVQEARCLKEDEARSIFVQLLSAIGYCHGEGVVHRDLKPDNVIVDEHGNVKIVDFGLGA---RFMPGQKLERLC----GAFQFIPPEIFLGLPYDGPKVDIWALGVLLYYMVTGIFPFVGSTLSEISKEVLQ---GRYEIPYNLSKDLRSMIGLLLATNARQRPTAQDLL 270
[Close]
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9QYK9|KCC1B_MOUSE (Calcium/calmodulin-dependent protein kinase type 1B OS=Mus musculus OX=10090 GN=Pnck PE=1 SV=1)

HSP 1 Score: 112.079 bits (279), Expect = 1.691e-25
Identity = 81/287 (28.22%), Postives = 146/287 (50.87%), Query Frame = 3 
Query: 1281 LMFERMRNIENINITRE-LASGGFGKIFICQNKFSTNNFLIK----KSINETENL-HREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFD---EKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSI--KQISNDMKLLIGSCLKANPELRQTGQQMIKSQLFINSFGRFNR 2108
            L+ ++  +I ++   RE L SG F ++ + Q + S +   +K    K++   E L   EI +  +  + + +  +  +  + +H YLAM    GG L   I +     EK+  +++ Q+L  ++ LH LGI+HRD+KP+N+++    E     + DFGL+K         Q  N+     GT  Y+APEL++  PY   +D+W+ G++   ++ G PPF   +  ++  ++ +  +Y F S     IS   K  I   L+ +P+ R T QQ ++  L+I+    F+R
Sbjct:    3 LLKKQTEDISSVYEIREKLGSGAFSEVMLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISHPN-IVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKI--------QAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILR-ASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALQ-HLWISGDAAFDR 278
[Close]
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q5APR8|CLA4_CANAL (Serine/threonine-protein kinase CLA4 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=CLA4 PE=1 SV=1)

HSP 1 Score: 116.701 bits (291), Expect = 1.810e-25
Identity = 74/267 (27.72%), Postives = 128/267 (47.94%), Query Frame = 3 
Query: 1320 ITRELASGGFGKIFICQNKFSTNNFLIKKSINETENLHREIFINSQFFYSDKLFK-----ISGLIRNENHPYLAMPYFPGGSLASYIEQVR-CLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELRQTGQQMIKSQLFINSFGRF 2102
            I  +   G  G +++ +     N  +  K ++      +E+ IN      D   K     +   +  +N  ++ M Y  GGSL   IE     L+EK+I  I ++ L  +  LH+  IIHRDIK DN++ D   N K+ DFG    + + +NK      ++ + GT  +MAPE+VK   Y  K+D+WS G++ +EM+ G+PP+      K L  +    T + K  + +SN +K  +  CL  +   R +  ++++     +  G+ 
Sbjct:  687 IVEKAGQGASGNVYLAEMIKDNNRKIAIKQMDLDAQPRKELIINEILVMKDSQHKNIVNFLDSYLIGDNELWVIMEYMQGGSLTEIIENNDFKLNEKQIATICFETLKGLQHLHKKHIIHRDIKSDNVLLDAYGNVKITDFGFCAKLTDQRNK------RATMVGTPYWMAPEVVKQKEYDEKVDVWSLGIMTIEMIEGEPPYLNEEPLKALYLIATNGTPKLKKPELLSNSIKKFLSICLCVDVRYRASTDELLEHSFIQHKSGKI 947
[Close]
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|O14427|CLA4_CANAX (Serine/threonine-protein kinase CLA4 OS=Candida albicans OX=5476 GN=CLA4 PE=3 SV=1)

HSP 1 Score: 116.316 bits (290), Expect = 2.239e-25
Identity = 74/267 (27.72%), Postives = 128/267 (47.94%), Query Frame = 3 
Query: 1320 ITRELASGGFGKIFICQNKFSTNNFLIKKSINETENLHREIFINSQFFYSDKLFK-----ISGLIRNENHPYLAMPYFPGGSLASYIEQVR-CLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELRQTGQQMIKSQLFINSFGRF 2102
            I  +   G  G +++ +     N  +  K ++      +E+ IN      D   K     +   +  +N  ++ M Y  GGSL   IE     L+EK+I  I ++ L  +  LH+  IIHRDIK DN++ D   N K+ DFG    + + +NK      ++ + GT  +MAPE+VK   Y  K+D+WS G++ +EM+ G+PP+      K L  +    T + K  + +SN +K  +  CL  +   R +  ++++     +  G+ 
Sbjct:  682 IVEKAGQGASGNVYLAEMIKDNNRKIAIKQMDLDAQPRKELIINEILVMKDSQHKNIVNFLDSYLIGDNELWVIMEYMQGGSLTEIIENNDFKLNEKQIATICFETLKGLQHLHKKHIIHRDIKSDNVLLDAYGNVKITDFGFCAKLTDQRNK------RATMVGTPYWMAPEVVKQKEYDEKVDVWSLGIMTIEMIEGEPPYLNEEPLKALYLIATNGTPKLKKPELLSNSIKKFLSICLCVDVRYRASTDELLEHSFIQHKSGKI 942
[Close]
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0BFM2 (Protein kinase domain-containing protein OS=Paramecium tetraurelia OX=5888 GN=GSPATT00028374001 PE=4 SV=1)

HSP 1 Score: 142.124 bits (357), Expect = 4.608e-33
Identity = 85/248 (34.27%), Postives = 134/248 (54.03%), Query Frame = 3 
Query: 1317 NITRELASGGFGKIFICQNKFSTNNFLIKKSINETE--------NLHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANP 2036
            ++ + L  G FG + + + +  T N    K++ + E        NL REI I  +  + + + K+     ++ + YL + Y  GGSL   I++ R L E+E  + LYQ  + I  LH++ IIHRDIKP+N++ D K N K+ DFG +  MD         NLK    GT++YMAPE++K    + K+DIW  G+++ EMV GKPPF G    +  + +   +  +++    +S D K LI   L+ANP
Sbjct:   40 SMQQTLGQGSFGWVTLVK-EIKTGNLFAMKAMRKEELFKYCTVDNLKREIKIQRKLHHPN-IIKLDSYFEDKTNVYLILEYAEGGSLFKKIKKERRLSEEEAFHYLYQTCLGIEYLHKMKIIHRDIKPENLLLDAKGNIKICDFGWSTEMD---------NLKKAFCGTIEYMAPEMIKSQSTNFKLDIWCLGVLLYEMVQGKPPFTGRNDQEKCVAILSGQQLKYEEF--VSEDCKALIAMILQANP 274
[Close]
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0BZI1 (Protein kinase domain-containing protein OS=Paramecium tetraurelia OX=5888 GN=GSPATT00033801001 PE=4 SV=1)

HSP 1 Score: 137.117 bits (344), Expect = 4.184e-31
Identity = 88/260 (33.85%), Postives = 136/260 (52.31%), Query Frame = 3 
Query: 1284 MFERMRNIENINITRE-LASGGFGKIFICQNKFSTNNFLIKKSINETE--------NLHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANP 2036
            M+   R+I +    ++ L  G FG + + + + ST   L  K++ + E        NL REI I  +  + + + K+     ++ + YL + Y  GGSL   I++ R L E E  + LYQ  + I+ LH+  IIHRDIKP+N++ D K N K+ DFG +          ++ NLK    GT++YMAPE++K    + K+DIW  G+++ EMV GKPPF G    +    +  L     K  + +S D K LI   L+ NP
Sbjct:   59 MYMCFRDISDFQAMQQTLGQGSFGWVTLVK-EISTGKLLAMKAMKKAELFKYCTVDNLKREIKIQRKLNHPN-IIKLDSYFEDKTNVYLVLEYAEGGSLFKQIKKQRHLSEDEASHYLYQTCLGIDYLHKQKIIHRDIKPENLLLDNKGNIKICDFGWS---------TEMGNLKKAFCGTIEYMAPEMIKSQSTNYKLDIWCLGVLLYEMVQGKPPFTGRNDQEKCQAI--LSGSPLKYDEYVSEDCKSLISMILQQNP 305
[Close]
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0BWA1 (Protein kinase domain-containing protein OS=Paramecium tetraurelia OX=5888 GN=GSPATT00032670001 PE=4 SV=1)

HSP 1 Score: 134.806 bits (338), Expect = 8.215e-31
Identity = 84/247 (34.01%), Postives = 128/247 (51.82%), Query Frame = 3 
Query: 1320 ITRELASGGFGKIFICQNKFSTNNFLIKKSINETE--------NLHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANP 2036
            + + L  G FG + + + +  T      K++ + E        NL REI I  +  +   +  +     ++ + YL + Y  GGSL   I++ R L E E  + LYQ  + I  LH++ IIHRDIKP+N++ D K N K+ DFG +  MD         NLK    GT++YMAPE++K    + K+DIW  G+++ EMV GKPPF G    +  + +  L   + K  + +S D K LI   L+ NP
Sbjct:    1 MQQTLGQGSFGWVTLVR-EIQTGKLFAMKAMKKAELFKYCTIDNLKREIKIQRKLNHPH-IIDLDSYFEDKTNVYLILEYAEGGSLFKRIKKQRRLSEDEAYHYLYQTCLGIEYLHKMKIIHRDIKPENLLLDAKGNIKICDFGWSTEMD---------NLKKAFCGTIEYMAPEMIKSQSTNYKLDIWCLGVLLYEMVQGKPPFTGKNDQEKCVAI--LSGQQLKYEESVSEDCKSLIAMILQPNP 234
[Close]
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: T2M6M6 (Mitogen-activated protein kinase kinase kinase 3 OS=Hydra vulgaris OX=6087 GN=MAP3K3 PE=2 SV=1)

HSP 1 Score: 132.109 bits (331), Expect = 2.736e-28
Identity = 83/264 (31.44%), Postives = 132/264 (50.00%), Query Frame = 3 
Query: 1326 RELASGGFGKIFICQN---------KFSTNNFLIKKSINETENLHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPF----PGMAIGKILLELRKLETYRFKSIKQISNDM----KLLIGSCLKANPELRQTGQQMI 2066
            R++ SGGFG +++C +         K+     +   ++ E E L REI +     + +++ +  G I+      + M Y  GGS+   I ++  LDEKE     +QIL  IN LH   IIHRDIK  NI+ D   N KL DFG +K +   +++   ++    V GT  +M+PE++ G+ Y  K DIWS G  ++EM+T KPP+    P  A+ KI  +          +I  + +D     K  +  C K +P LR    +++
Sbjct:  371 RQIGSGGFGTVYLCVDLNTGKELAMKYIETGHINTAALKEVEILQREISLYKTLNH-ERIVEYYGTIQANTSISIFMEYMEGGSIHDKISKIGALDEKETSCYCFQILEGINYLHSKNIIHRDIKGANILLDSSGNCKLADFGASKQIQTIRSQTGCKS----VHGTPYWMSPEVINGAGYGRKADIWSLGCTVLEMLTTKPPWFQFEPMAALFKIATQT---------TIPHLPDDSSISCKRFVDDCFKRDPSLRPNALELL 620
[Close]
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: G0R2T0 (Protein kinase domain protein OS=Ichthyophthirius multifiliis (strain G5) OX=857967 GN=IMG5_181310 PE=3 SV=1)

HSP 1 Score: 129.413 bits (324), Expect = 5.072e-28
Identity = 83/246 (33.74%), Postives = 132/246 (53.66%), Query Frame = 3 
Query: 1329 ELASGGFGKIFICQNKFSTNNFLIK-------KSINETENLHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELR 2045
            +L  G FG++ +  NK +   + IK        S+ E + + REI ++SQ  + + +        NE   ++ + Y   G+L SY+++ +   EKE     YQ    +  LH + I+HRDIKP+NI+ DE    KL DFG       W  +D +EN ++   GT +YMAPE+V    Y  +IDIW+ G++I E + G  PF G ++ +I L+++K +   F +  QI++  K LI   L+ANP  R
Sbjct:   38 QLGMGSFGEVKLAINKKTQEKYAIKIMNLKNMHSLQEIQGIEREIRVHSQLNHPNIIQYYDSFQENE-LVFIVLDYAQNGNLYSYLQKKKHFSEKEAFKFFYQTCQALKYLHEMNIVHRDIKPENILIDENLQVKLCDFG-------WCTED-MENPRNTFCGTYEYMAPEIVFRQQYDYRIDIWALGVLIYEFLHGSAPFKGKSLKEIQLKIQKGDVL-FST--QITDLSKSLICKLLQANPLKR 271
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: hunk (hormonally up-regulated Neu-associated kinase [Source:ZFIN;Acc:ZDB-GENE-050309-240])

HSP 1 Score: 120.939 bits (302), Expect = 5.760e-28
Identity = 81/268 (30.22%), Postives = 128/268 (47.76%), Query Frame = 3 
Query: 1287 FERMRNIENINITRELASGGFGKIFICQNKFSTNNFLIK--------KSINETENLHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELRQTGQQMI 2066
            F   + + N  I R+L  G F K+    +  +     +K        K    T+NL RE  I  Q      + ++  ++  EN  YL M   PGG+L +YI + + LDE+E    + Q++M +  LHR G++HRD+K +N++ DE+ N KLIDFGL+ C       +      S   G+  Y APEL+    Y  K+D+WS G+ +  M+TG  PF         L  R ++         +S+    L+ S L+ +P  R    Q++
Sbjct:   44 FYHTKRVGNYLIGRKLGEGSFAKVREGLHALTGEKVAVKVIDKRKAKKDSYVTKNLRREGQIQ-QMIRHPNITQLLDILETENSYYLVMELCPGGNLMNYIYEKKRLDEREAQKYIRQLVMAVEHLHRAGVVHRDLKIENLLLDEEDNIKLIDFGLSNCAGILGYSEPF----STQCGSPAYAAPELLSRKKYGPKVDVWSIGVNMYAMLTGTLPFTVEPFSLKALHQRMVDKDMNPLPPSVSSAAVSLLKSLLEPDPAKRPNIHQVM 306
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: camk1ga (calcium/calmodulin-dependent protein kinase IGa [Source:ZFIN;Acc:ZDB-GENE-030131-7594])

HSP 1 Score: 110.923 bits (276), Expect = 1.668e-25
Identity = 79/266 (29.70%), Postives = 132/266 (49.62%), Query Frame = 3 
Query: 1302 NIENINITRE-LASGGFGKIFICQNKFSTNNF----LIKKSINETENLHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVF---DEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSI--KQISNDMKLLIGSCLKANPELRQTGQQMIK 2069
            NI+++   RE L SG F ++F+ + +  T NF     +KK   +  NL  EI +  +  +++ +  +        H YL M    GG L   I       EK+   ++ Q+L  +  LH+  ++HRD+KP+N++F   DEK    + DFGL+K +D          +     GT  Y+APE++   PYS  +D WS G++   +++G PPF      ++  ++ + E Y F S     IS   K  I + L+ NP+ R T +Q ++
Sbjct:   16 NIKDVFEFREILGSGSFSEVFLVRER-KTGNFYALKCVKKKQLDHSNLENEITVLKRIKHNN-VVSLEDFYETRTHYYLVMELVSGGELFDRILDRGVYTEKDASLVIRQVLEAVTYLHQNSVVHRDLKPENLLFYNQDEKAKIMISDFGLSKMVD--------HGVMQTACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLSGYPPFYDDNETRLFSKIMRAE-YAFHSPYWDNISESAKDFIRNMLEKNPKNRFTSEQALR 270
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: stk10 (serine/threonine-protein kinase 10 [Source:NCBI gene;Acc:103041064])

HSP 1 Score: 110.538 bits (275), Expect = 1.699e-24
Identity = 86/280 (30.71%), Postives = 133/280 (47.50%), Query Frame = 3 
Query: 1320 ITRELASGGFGKIFICQNK----FSTNNFLIKKSINETENLHREIFINSQ------------FFYSDKLFKISGLIRNENHPYLAMPYFPGGSL-ASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELV-----KGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELRQTGQQMIKSQLFINSF 2093
            I  EL  G FGK++  QNK     +    +  KS  E E+   EI I +             F+Y  KL             ++ + + PGG++ A+ +E  R L EK+I  +  Q+L  +  LH + IIHRDIK  N++       KL DFG++      KN   L+   S++ GT  +MAPE+V     K +PY  K DIWS G+ ++E+   +PP   +   ++LL++ K +        + S D K  +   L  NPE R T  Q+++   F+ S 
Sbjct:   37 IVGELGDGAFGKVYKAQNKETGVLAAAKVIETKSEEELEDYMVEIDILASCDHHYIVKLLDAFYYEHKL-------------WIMIEFCPGGAVDATMLELDRGLTEKQIQVVCKQMLEALVYLHSMKIIHRDIKAGNVLLMLDGGIKLADFGVS-----AKNTKTLQRRDSFI-GTPYWMAPEVVMCETTKDAPYEYKADIWSLGITLIELAQIEPPHHELNPMRVLLKIAKSDPPTLDQPSKWSADFKDFLRKALDKNPETRPTAAQLLE-HPFVTSV 296
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: pak6a (p21 (RAC1) activated kinase 6 [Source:NCBI gene;Acc:103035957])

HSP 1 Score: 109.383 bits (272), Expect = 2.691e-24
Identity = 76/261 (29.12%), Postives = 126/261 (48.28%), Query Frame = 3 
Query: 1329 ELASGGFGKIFICQNKFSTNNFLIKKSINETENLHREIFINSQFFYSD-------KLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELRQTGQQMIKSQLFINS 2090
            ++  G  G + I + K S    +  K ++      RE+  N      D       ++FK S L+  E   ++ M Y  GG+L + + + R L E++I  +   +L  +  LH  G+IHRDIK D+I+       KL DFG   C    K+   +   KS V GT  +MAPE++  SPY  ++D+WS G+++VEMV G+PP+        +  LR       ++I+Q+S  +K  +   L   P  R +   +++    + S
Sbjct:  430 KIGEGSTGVVCIAREKHS-GRLVAVKMMDLRRQQRRELLFNEVVIMRDYQHKNVVEMFK-SALVEEEL--WVIMEYLQGGALTNIVSETR-LSEEQIATVCEAVLQALAYLHSQGVIHRDIKSDSILLSLDGRIKLSDFGF--CAQISKD---IPKRKSLV-GTPYWMAPEVISKSPYGTEVDVWSMGIMVVEMVDGEPPYFSETPVAAMKRLRDEPAPTIRNIQQVSPVLKDFLDRMLTREPMERASATDLLEHPFLLQS 679
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: pak1 (p21 protein (Cdc42/Rac)-activated kinase 1 [Source:ZFIN;Acc:ZDB-GENE-030826-29])

HSP 1 Score: 108.227 bits (269), Expect = 2.729e-24
Identity = 74/282 (26.24%), Postives = 135/282 (47.87%), Query Frame = 3 
Query: 1278 ELMFERMRNIENINITRE-------LASGGFGKIFICQNKFSTNNFLIKKSINETENLHREIFINSQFFYSDKLFKISGLIRNENHPYLA-------MPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELRQTGQQMIKSQLF 2081
            E + E++R+I ++   ++       +  G  G ++   +  +T   +  K +N  +   +E+ IN              L+  EN PYL        M Y  GGSL   + +  C+DE +I  +  + L  +  LH   +IHRDIK DNI+     + KL DFG    +   ++K      +S + GT  +MAPE+V    Y  K+DIWS G++ +EM+ G+PP+      + L  +    T   ++ +++S+  +  +  CL+ + E R + +++++ Q  
Sbjct:  238 EEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAID-IATGQEVAIKQMNLQQQPKKELIINEI------------LVMRENKPYLVGDELWVVMEYLAGGSLTDVVTET-CMDEAQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSK------RSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSSVFRDFLNRCLEMDVEKRGSAKELLQHQFL 499
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: aurka (aurora kinase A [Source:ZFIN;Acc:ZDB-GENE-040801-161])

HSP 1 Score: 104.375 bits (259), Expect = 6.590e-25
Identity = 71/256 (27.73%), Postives = 128/256 (50.00%), Query Frame = 3 
Query: 1302 NIENINITRELASGGFGKIFICQNKFSTNNFLIKKSINETE--------NLHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELR 2045
            +++N +I R L  G FG +++ + K ST   L  K + +++         L REI I S   + + + ++ G   +    YL + Y P G L   ++++   DE+   + +  +   +   H   +IHRDIKP+N++   K   K+ DFG       W +     + ++ + GT+ Y+ PE+++G  +  K+D+WS G++  E + G+PPF      +    + K++  RF S   +S+  K LI + LK NP  R
Sbjct:   11 SLDNFDIGRPLGKGKFGNVYLAREK-STKFILALKVLFKSQLEKSGVEHQLRREIEIQSHLRHPN-ILRLYGYFHDRTRVYLILEYAPRGELYKLLQKLGKFDEERSASYVADMADALIYCHSKKVIHRDIKPENLLLGLKGELKIADFG-------W-SVHAPSSRRATLCGTLDYLPPEMIEGRTHDEKVDLWSLGVLCYEFLVGRPPFESETHNETYRRISKVDL-RFPS--HLSDGAKDLIANLLKHNPHTR 253
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004683.1 (pep scaffold:Pmarinus_7.0:GL488517:199:5283:1 gene:ENSPMAG00000004265.1 transcript:ENSPMAT00000004683.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 99.7525 bits (247), Expect = 1.797e-24
Identity = 51/139 (36.69%), Postives = 84/139 (60.43%), Query Frame = 3 
Query: 1500 RNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPG 1916
            + E   YL + +  GG L + + +     E+++   L ++ + ++ LH LGII+RD+KP+NI+ DE  +  L DFGL+K     ++ D  +   S+  GTV+YMAPE+V    +++  D WSFG+++ EM+TG  PF G
Sbjct:    3 QTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDESGHIGLTDFGLSK-----ESIDHEKKAYSFC-GTVEYMAPEVVNRKGHTHSADWWSFGVLMFEMLTGTLPFQG 135
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: slka (STE20-like kinase a [Source:ZFIN;Acc:ZDB-GENE-050411-66])

HSP 1 Score: 104.375 bits (259), Expect = 3.558e-23
Identity = 81/260 (31.15%), Postives = 131/260 (50.38%), Query Frame = 3 
Query: 1329 ELASGGFGKIFICQNK----FSTNNFLIKKSINETENLHREIFINSQFFYSDKLFKISGLIRN---ENHPYLAMPYFPGGSL-ASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELV-----KGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELRQTGQQMIK 2069
            EL  G FGK++  QNK     +    +  KS  E E+   EI I +   + +    I GL+     EN  ++ + + PGG++ A  +E  R L E +I  +  Q+L  +N LH   IIHRD+K  NI+   + + KL DFG++      KN   L+   S++ GT  +MAPE+V     K +PY  K DIWS G+ ++E+   +PP   +   +++L++ K +        + S +    +  CL  NPE R    Q+++
Sbjct:   38 ELGDGAFGKVYKAQNKESGVLAAAKVIETKSEEELEDYMVEIEILALCDHPN----IVGLLNAFYYENKLWIFIEFCPGGAVDAIMLELERGLAEPQIRVVCKQMLEALNYLHTHRIIHRDLKAGNILLTFEGDVKLADFGVSA-----KNTRTLQRRDSFI-GTPYWMAPEVVMCETMKDAPYDYKADIWSLGITLIELAQMEPPNHELNPMRVMLKIAKNDPPSLSFPSKWSAEFTDFLKKCLDKNPETRWNALQLLQ 287
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: pak4 (p21 protein (Cdc42/Rac)-activated kinase 4 [Source:ZFIN;Acc:ZDB-GENE-040704-69])

HSP 1 Score: 99.7525 bits (247), Expect = 5.960e-22
Identity = 68/260 (26.15%), Postives = 132/260 (50.77%), Query Frame = 3 
Query: 1329 ELASGGFGKIFICQNKFSTNNFLIKKSINETENLHREIFINS----QFFYSDKLFKI--SGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELRQTGQQMIKSQLFINS 2090
            ++  G  G + +  ++ S     +KK ++  +   RE+  N     + ++ + +  +  S L+ +E   ++ M +  GG+L   +   R ++E++I  +   +L  +  LH  G+IHRDIK D+I+       KL DFG   C    K   ++   KS V GT  +MAPE++   PY  ++D+WS G++++EMV G+PP+      + +  +R     + K+I++ S  ++  +   L  +P LR T  ++++     N+
Sbjct:  424 KIGEGSTGVVCLAVDRRSGRQVAVKK-MHLRKQQRRELLFNEVVIMREYHHENVVDMYNSYLVADEL--WVVMEFLEGGALTDIVTHTR-MNEEQIATVCVSVLRALAYLHGQGVIHRDIKSDSILLTADGRIKLSDFGF--CAQVSK---EVTRRKSLV-GTPYWMAPEVISRLPYGPEVDVWSLGIMVIEMVDGEPPYFNEPPLQAMRRIRDNVPPKMKNIQKASPLLRGFLDQMLVRDPALRATALELLQHPFLQNA 673
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:ZFIN;Acc:ZDB-GENE-120215-96])

HSP 1 Score: 99.3673 bits (246), Expect = 6.174e-22
Identity = 70/214 (32.71%), Postives = 100/214 (46.73%), Query Frame = 3 
Query: 1332 LASGGFGKIFIC------------QNKFSTNNFLIKKSINETE-------NLHREIFINSQFFYSDKLFKISGLIRNENHPYLA--MPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPF 1910
            L  G FG++++C            Q +F   +    K +N  E       NL  E  +  Q+F         G +R+     L+  M Y PGGS+   +     L E        QIL  ++ LH   I+HRDIK  NI+ D   N KL DFG +K +    +  Q   ++S V GT  +M+PE++ G  Y  K DIWS G  +VEM+T KPP+
Sbjct:  365 LGQGAFGRVYLCYDADTGRELAVKQVQFDPGSVETSKEVNALECEIQLLKNLQHERIV--QYF---------GCLRDPQQKTLSIFMEYMPGGSIKDQLRAYGALTENVTRKYTRQILEGVSFLHGNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICS--QGTAMRS-VTGTPYWMSPEVINGEGYGRKADIWSVGCTVVEMLTEKPPW 564
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: YPL150W_mRNA (Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study [Source:SGD;Acc:S000006071])

HSP 1 Score: 115.161 bits (287), Expect = 7.516e-27
Identity = 86/281 (30.60%), Postives = 140/281 (49.82%), Query Frame = 3 
Query: 1278 ELMFERMRNIENINITRELASGGFGKIFICQNKFSTNNFLIKKSINETENLHREIFINSQF--FYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAK-CMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSN-KIDIWSFGMVIVEMVTGKPPF----PGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELRQTGQQMIKSQLFINSFG 2096
            +   + +  + N  I +++  G FGK+++  ++ +     +K S     N+ RE+F + QF   Y  KL+++   I  E+  ++A+ Y PG  L  ++  +R +   E G +  QI   +   H +  +HRD+K +NI+ D+  NAKL DFG  + CM     K  LE     V GT  YMAPEL++   Y   KIDIWS G+++  ++TG  PF          KI+ E  K +       K I +D + LI   L  NP  R +  Q+++   F+  +G
Sbjct:   29 QFTSDELTEVGNYKILKQIGEGSFGKVYLALHRPTHRKVCLKTSDKNDPNIVREVFYHRQFDFPYITKLYEV---IVTESKVWMALEYCPGKELYDHLLSLRRISLLECGELFAQISGAVYYAHSMHCVHRDLKLENILLDKNGNAKLTDFGFTRECM----TKTTLET----VCGTTVYMAPELIERRTYDGFKIDIWSLGVILYTLITGYLPFDDDDEAKTKWKIVNEEPKYDA------KVIPDDARDLISRLLAKNPGERPSLSQVLR-HPFLQPYG 291
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: MKK2 (MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication [Source:SGD;Acc:S000006061])

HSP 1 Score: 110.538 bits (275), Expect = 5.990e-26
Identity = 81/266 (30.45%), Postives = 130/266 (48.87%), Query Frame = 3 
Query: 1332 LASGGFGKIFICQNKFSTNNFLIKK--SINETENLHREIFINSQF---FYSDKLFKISGLIRNENHP--YLAMPYFPGGSL-ASY---IEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLE-----TYRFKSIKQI----SNDMKLLIGSCLKANPELRQTGQQMIK 2069
            L  G  G +  C+ K     F +K   ++N      ++IF   QF   F SD + +  G+  +E     Y+AM Y  G SL A+Y   +++   + E+ IG I   +L  ++ LH   +IHRDIKP NI+ +EK   KL DFG++         + + +L     GT  YMAPE ++G PYS   D+WS G+ ++E+  G+ PF    I + +  +  L      + + K   ++    S   +  I  CLK +   R + +QM+K
Sbjct:  220 LGEGAGGSVAKCRLKNGKKVFALKTINTMNTDPEYQKQIFRELQFNKSFKSDYIVQYYGMFTDEQSSSIYIAMEYMGGKSLEATYKNLLKRGGRISERVIGKIAESVLRGLSYLHERKVIHRDIKPQNILLNEKGEIKLCDFGVS--------GEAVNSLAMTFTGTSFYMAPERIQGQPYSVTCDVWSLGLTLLEVAGGRFPFESDKITQNVAPIELLTMILTFSPQLKDEPELDISWSKTFRSFIDYCLKKDARERPSPRQMLK 477
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: BCK1 (MAPKKK acting in the protein kinase C signaling pathway; the kinase C signaling pathway controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p; MAPKKK is an acronym for mitogen-activated protein (MAP) kinase kinase kinase [Source:SGD;Acc:S000003631])

HSP 1 Score: 108.227 bits (269), Expect = 1.365e-24
Identity = 100/360 (27.78%), Postives = 161/360 (44.72%), Query Frame = 3 
Query: 1101 FVMMRINCENKLLAIPSTPQTVIEAKRVIACKCGVSIDDFYCIDLYNSDKPNDWDTYEYELMFERMRNIENINITRE------------LASGGFGKIFICQN---------------KFSTNNFLIKKSINETENLHREIFINSQFFYSDKLFKISGL-IRNENHPY-LAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSP-YSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIG--------SCLKANPELRQTGQQMI 2066
            F+   +N +NK L    TP+   +  R IA +  ++  +   +   N+     W T   E+    M +I     ++             +  G FG +++C N               K+S+ N  I   ++  E L  E+   S     D L  +  L   N+N+ Y L + Y  GGS+ S I      DE  I ++  Q+L  +  LH  GI+HRD+K DN++ D+    K+ DFG+++     K+KD   N    + GTV +MAPE+V     YS K+DIWS G +++EM  GK P+  + +   + ++ K      KS   I  D   LI         +C + NPE R T  +++
Sbjct: 1096 FIQDGLNGKNKPLNQAKTPKRT-KTIRTIAHEASLARKNSVKLKRQNTKM---WGTRMVEVTENHMVSINKAKNSKGEYKEFAWMKGEMIGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAI---LSTVEALRSEV---STLKDLDHLNIVQYLGFENKNNIYSLFLEYVAGGSVGSLIRMYGRFDEPLIKHLTTQVLKGLAYLHSKGILHRDMKADNLLLDQDGICKISDFGISR-----KSKDIYSNSDMTMRGTVFWMAPEMVDTKQGYSAKVDIWSLGCIVLEMFAGKRPWSNLEVVAAMFKIGK-----SKSAPPIPEDTLPLISQIGRNFLDACFEINPEKRPTANELL 1435
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: MKK1 (MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication [Source:SGD;Acc:S000005757])

HSP 1 Score: 105.916 bits (263), Expect = 1.749e-24
Identity = 72/228 (31.58%), Postives = 117/228 (51.32%), Query Frame = 3 
Query: 1257 DWDTYEYELMFERMRNIENINITRELASGGFGKIFICQNKFSTNNFLIK--KSINETENLHREIFINSQF---FYSDKLFKISGLIRNENHP--YLAMPYFPGGSLAS----YIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPP 1907
            D + ++Y  + +R   IE + I   L  G  G +  C+ K  +  F +K   ++N      ++IF   QF   F S+ + +  G+  ++ +   Y+AM Y  G SL +     +E+   + EK +G I   +L  ++ LH   +IHRDIKP NI+ +E    KL DFG++         + + +L +   GT  YMAPE ++G PYS   D+WS G+ I+E+  GK P
Sbjct:  208 DENGWKYANLKDR---IETLGI---LGEGAGGSVSKCKLKNGSKIFALKVINTLNTDPEYQKQIFRELQFNRSFQSEYIVRYYGMFTDDENSSIYIAMEYMGGRSLDAIYKNLLERGGRISEKVLGKIAEAVLRGLSYLHEKKVIHRDIKPQNILLNENGQVKLCDFGVSG--------EAVNSLATTFTGTSFYMAPERIQGQPYSVTSDVWSLGLTILEVANGKFP 421
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: STE11 (Signal transducing MEK kinase; involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000004354])

HSP 1 Score: 105.916 bits (263), Expect = 4.424e-24
Identity = 54/129 (41.86%), Postives = 79/129 (61.24%), Query Frame = 3 
Query: 1527 MPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFP 1913
            + Y PGGS++S +      +E  I N   QIL+ +  LH+  IIHRDIK  NI+ D K   K+ DFG++K +     K   +N ++ + G+V +M+PE+VK +  + K DIWS G V++EM TGK PFP
Sbjct:  533 LEYVPGGSVSSMLNNYGPFEESLITNFTRQILIGVAYLHKKNIIHRDIKGANILIDIKGCVKITDFGISKKLSPLNKK---QNKRASLQGSVFWMSPEVVKQTATTAKADIWSTGCVVIEMFTGKHPFP 658
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO41410 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4G7])

HSP 1 Score: 122.865 bits (307), Expect = 2.680e-31
Identity = 83/267 (31.09%), Postives = 135/267 (50.56%), Query Frame = 3 
Query: 1332 LASGGFGKIFICQNKFSTNNFLIKK---------SINETENLHREI-FINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPF----PGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELRQTGQQMIKSQLFINS 2090
            L +G FG++++C +  +     +K+         + NE + L  EI F+ +  F ++++ +  G+  ++ H Y+ M Y PGGS+  +I+Q   L+E        QIL  I  LH   I+HRDIK  NI+ D   N KL DFG +K +   ++K    +    V GT  +MAPE++ G  Y  K D+WS G  +VEM+T KPP+    P  A+ KI  +  + E         +S D    + S L+ N + R +  ++++     NS
Sbjct:   10 LGAGAFGQVYMCHDLDTGRELAVKQIETGQLNSSTKNEVKALEGEIEFMKA--FRNERIVQYYGIETDDLHIYIFMEYLPGGSIHEHIKQHGALNESLTRKYSRQILEGILYLHTNRIVHRDIKGANILRDLYGNVKLADFGASKRLQTIRSKTGFRS----VHGTPYWMAPEVINGEGYGRKADVWSVGCTVVEMLTTKPPWADFEPMAALFKIATQPTEPEL-----PSDLSVDAVEFVRSTLRMNSKSRPSADELLRFSFVTNS 265
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO45846 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRL1])

HSP 1 Score: 110.923 bits (276), Expect = 7.187e-27
Identity = 77/291 (26.46%), Postives = 140/291 (48.11%), Query Frame = 3 
Query: 1242 SDKPNDWDTYE--YELMFERMRNIENINITRELASGGFGKIFICQNKFSTNNFLIKKSINETENLHREIFINSQFFYSD----KLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELRQTGQQMIKSQLFINSFG 2096
            SD P   + +    E++ +  R  EN+    ++  G  G + +  +K +     +KK ++  +   RE+  N      D     + ++ G     +  ++ M +  GG+L   +     L E+++  +   +L  +  LH  G+IHRDIK D+I+       KL DFG    + E      +   KS V GT  +MAPE++   PY  ++DIWS G++++EMV G+PP+      + + +LR LE    ++  QIS  ++  + + L  +P  R T  +++ +  FI + G
Sbjct:    3 SDTPVTHEQFRRHLEVVVQSTRQPENLGNFMKIGEGSTGIVCLATDKRTGRQVAVKK-MDLKKQQRRELLFNEVVIMRDYPHPNIVEMYGSHLVGDELWVVMEFLEGGTLTDIVTHTN-LSEEQVACVCRAVLKALTFLHSQGVIHRDIKSDSILLTSNGTVKLSDFGFCAQVTE-----DMPRRKSLV-GTPYWMAPEVISRKPYGTEVDIWSLGIMVLEMVDGEPPYFNEPPLQAMRKLRDLEPPTSRNPIQISPRLQSFLDNALIRDPLYRATAFELL-NHPFIRNVG 284
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO48741 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RIM4])

HSP 1 Score: 112.849 bits (281), Expect = 1.207e-25
Identity = 84/274 (30.66%), Postives = 137/274 (50.00%), Query Frame = 3 
Query: 1311 NINITRELASGGFGKIFICQNK----FSTNNFLIKKSINETENLHREIFINSQFFYSDKLFKISGLIR---NENHPYLAMPYFPGGSLAS-YIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELV-----KGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELRQTGQQMIKSQLFINSF 2093
            N  +  EL  G FGK++  Q+K     S    +I    NE E+   EI I S+  + +    + GL     ++   ++ + +  GG+L    +E  R L+E EI  +  Q+   +  LH   +IHRD+K  N++     N K+ DFG++      KNK  L+   +++ GT  +MAPE+V     K  PY  K DIWS G+ ++E+    PP   M   ++L ++ K +   F +  + SND+   + SC+  NP++R +  +MIK   FI  F
Sbjct:   21 NWELVGELGDGSFGKVYKAQHKTESSLSAAKIIIVNDENELEDFMVEIDILSECKHKN----LVGLFETFLHDGKLWMMLEFCSGGALDDLMLELERGLNEPEIRAVTRQLFEGLQFLHNHKVIHRDLKAGNLLLASDGNVKMADFGVS-----AKNKKTLQKRSTFI-GTPYWMAPEVVVTETYKDDPYDYKADIWSAGITLIELAQMVPPNHNMHPMRVLFKIPKSDPPTFDNPNKWSNDLNDFLASCVVKNPDMRASATEMIK-HPFIADF 283
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO35437 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SLH0])

HSP 1 Score: 107.457 bits (267), Expect = 1.557e-25
Identity = 69/255 (27.06%), Postives = 123/255 (48.24%), Query Frame = 3 
Query: 1302 NIENINITRELASGGFGKIFICQNKFSTNNFLIK-------KSINETENLHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELR 2045
            N+ + +I + L  G FG +++ + K S     +K       +  N    L REI I S   +++ + ++ G   ++   YL + Y P G L   +      DEK     + Q+   +   H   +IHRDIKP+N++ + K + K+ DFG       W +     + ++ + GT+ Y+ PE+++G  +  K+D+WS G++  E + GKPPF      +    + +++  RF S   +S   + LI   L+ NP  R
Sbjct:   44 NLSDFDIGKPLGKGKFGNVYLAREKKSKYIVALKVLFKSQLQKSNVEHQLRREIEIQSHLRHNN-ILRLFGYFYDDTRVYLILEYAPRGELYKELTACEKFDEKRAAKYIRQLADALAYCHSKKVIHRDIKPENLLLNYKGDIKIADFG-------W-SVHAPSSRRTTLCGTLDYLPPEMIEGKEHDEKVDLWSIGVLCYEFLVGKPPFEAEGHNETYRRISRVD-LRFPS--HVSPGARDLISKLLQHNPNNR 286
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO36253 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SJ85])

HSP 1 Score: 107.071 bits (266), Expect = 1.619e-25
Identity = 72/255 (28.24%), Postives = 127/255 (49.80%), Query Frame = 3 
Query: 1332 LASGGFGKIFICQNKFSTNNFLIK-----KSINETENLHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVF---DEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSI--KQISNDMKLLIGSCLKANPELRQTGQQMI 2066
            L +G F ++ + + K + + F +K     +   + E++  EI I  +  + + +  +  +  N++H YL M    GG L   I +     E++   ++ QIL   + LH LGI+HRD+KP+N+++   DE     + DFGL+K   +    D          GT  Y+APE++K  PY   +D WS G++   ++ G PPF   +   +  ++ + E Y F S    +IS   K  I   ++ +P+LR T +Q +
Sbjct:   23 LGTGAFSEVVLAEEKATGSLFAVKCISKKELKGKEESVENEIAILKKVRHKN-IIGLKDIFDNKSHLYLVMDLVQGGELFDRIVEKGNYTEQDASALVQQILEAADYLHSLGIVHRDLKPENLLYYSPDEDSKIMISDFGLSKIEAQGSFMDT-------ACGTPGYVAPEVLKQQPYGKAVDCWSIGVITYILLCGYPPFYDDSDANLFAQIMRAE-YEFDSPYWDEISESAKDFIRHLMELDPKLRYTCRQAL 268
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: camk1gb (calcium/calmodulin-dependent protein kinase type 1D [Source:NCBI gene;Acc:101164726])

HSP 1 Score: 115.546 bits (288), Expect = 5.748e-27
Identity = 79/277 (28.52%), Postives = 134/277 (48.38%), Query Frame = 3 
Query: 1302 NIENI-NITRELASGGFGKIFICQNKFSTNNFLIK---KSINETENLHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVF---DEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSI--KQISNDMKLLIGSCLKANPELRQTGQQMIKSQLFINSFGRFN 2105
            NI+ I ++  EL SG F ++F+ + + +   F +K   K      NL  E+ +  +  + + +  +  +  +  H YL M    GG L   I       EK+   ++ Q+L  ++ LH+ GI+HRD+KP+NI++   DE     + DFGL+K  D          + S   GT  Y+APE++   PYS  +D WS G++   ++ G PPF   +  K+  ++ K + Y F S     IS   K  I + ++  P +R + +Q ++    I    R N
Sbjct:   16 NIQEIFDLMEELGSGAFSEVFMVRERKTGKKFAMKCIKKKKKRDINLENEMAVLRRIKH-ENVVGLEDIYESRTHYYLIMQLVSGGELFDRILDRGMYTEKDASRVIQQVLQAVSYLHQNGIVHRDLKPENILYYSQDEDSKIMISDFGLSKMTD--------TGIMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEESETKLFSKIMKAQ-YEFDSPFWDDISESAKDFIRNMMQKTPSMRYSTEQALRHPWIIGKTARSN 282
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: hunk (hormonally up-regulated Neu-associated kinase [Source:NCBI gene;Acc:101172599])

HSP 1 Score: 117.472 bits (293), Expect = 7.225e-27
Identity = 75/217 (34.56%), Postives = 111/217 (51.15%), Query Frame = 3 
Query: 1287 FERMRNIENINITRELASGGFGKIFICQNKFSTNNFLIKKSINE---------TENLHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPF 1910
            F   + + N  I R+L  G F K+    +  ST   +  K I++         T+NL RE  I  Q      + ++  ++  EN  YL M   PGG+L S I   + LDE+E    + Q+++ +  LHR G++HRD+K +N++ DEK N KLIDFGL+ C       D      S   G+  Y APEL+    Y  K+D+WS G+ +  M+TG  PF
Sbjct:   46 FYHTKRVGNYLIGRKLGEGSFAKVKEGLH-VSTGEKVAVKVIDKRKAKKDSYVTKNLRREGNIQ-QMIRHPNIAQLLDILETENSYYLVMELCPGGNLMSCIYDKKHLDERETQKYIRQLVLAVEHLHRAGVVHRDLKIENLLLDEKNNIKLIDFGLSNCAGILGYSDPF----STQCGSPAYAAPELLSRKKYGPKVDVWSIGVNMYAMLTGGLPF 256
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: chek1 (checkpoint kinase 1 [Source:NCBI gene;Acc:101170780])

HSP 1 Score: 113.62 bits (283), Expect = 2.356e-26
Identity = 80/270 (29.63%), Postives = 140/270 (51.85%), Query Frame = 3 
Query: 1305 IENINITRELASGGFGKIFICQNKFSTNNFLIK-----KSINETENLHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPY-SNKIDIWSFGMVIVEMVTGKPPF--PGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELRQTGQQMIKSQLFINS 2090
            +++ ++ + L  G +G++ +  N+ +     +K     ++    EN+ +EI I+    + + + +  G  R     YL + Y  GG L   IE    + E++      Q++  +  LH+LGI HRDIKP+NI+ D+K N KL DFGLA  M  +K +++  N    + GT+ Y+APEL+  S Y +   DIW+ G+V+  M+ G+ P+  P  +  +    L++ +TY     K+I      L+   L+ NP  R TG+++ K + F   
Sbjct:    6 VQDWDVVQTLGEGAYGEVRLLVNRQTEEAVAVKVIDTSQAEECAENVKKEICIHKILNHCN-IVRFFGHRREGTTVYLFLEYCTGGELFDRIEPDVGMPERDAHRFFQQLIAAVEYLHKLGITHRDIKPENILLDDKDNLKLTDFGLA-TMFRFKGRERRLN---RLCGTLPYVAPELLSQSEYHAQPADIWACGIVLTAMLAGELPWDQPTESCQEYADWLQR-KTY-LPPWKKIQPAPLSLLSKLLQPNPNTRITGEELKKDRWFTQG 268
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: pak6a (p21 (RAC1) activated kinase 6 [Source:NCBI gene;Acc:101175447])

HSP 1 Score: 109.383 bits (272), Expect = 2.533e-24
Identity = 75/261 (28.74%), Postives = 126/261 (48.28%), Query Frame = 3 
Query: 1329 ELASGGFGKIFICQNKFSTNNFLIKKSINETENLHREIFINSQFFYSD-------KLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELRQTGQQMIKSQLFINS 2090
            ++  G  G + I   K +     +K  ++      RE+  N      D       ++FK S L+  E   ++ M Y  GG+L + + + R L E++I  +   +L  +  LH  G+IHRDIK D+I+       KL DFG   C    K+   +   KS V GT  +MAPE++  SPY  ++D+WS G+++VEMV G+PP+        +  LR  +    ++I Q+S  +K  +   L  +P  R +   +++    + S
Sbjct:  426 KIGEGSTGVVCIATEKHTGRQVAVKM-MDLRRQQRRELLFNEVVIMRDYQHKNVVEMFK-SALVEEEL--WVIMEYLQGGALTNIVSETR-LSEEQIATVCEAVLQALAYLHSQGVIHRDIKSDSILLTLDGRVKLSDFGF--CAQISKD---IPKRKSLV-GTPYWMAPEVISKSPYGTEVDVWSMGIMVVEMVDGEPPYFSETPVAAMKRLRDEQAPTVRNISQVSPVLKHFLDRMLTRDPLERASATDLLEHPFLLQS 675
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: aurka (aurora kinase A [Source:NCBI gene;Acc:101165631])

HSP 1 Score: 107.071 bits (266), Expect = 3.099e-24
Identity = 68/260 (26.15%), Postives = 124/260 (47.69%), Query Frame = 3 
Query: 1287 FERMRNIENINITRELASGGFGKIFIC---QNKFSTN-NFLIKKSINET---ENLHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELR 2045
            + +  ++E+ +I R L  G FG +++    Q KF      L KK +        L RE+ I S   + + + ++ G   + +  YL + + P G L   +++     E      + ++   ++  H   +IHRDIKP+N++       K+ DFG       W +     + +S + GT+ Y+ PE+++G  +  K+D+WS G++  E + GKPPF      +    + ++E Y + +   IS+  K L+   LK NP  R
Sbjct:  160 YRKRWSLEDFDIGRPLGKGKFGNVYLARERQTKFILALKVLFKKQLERAGVEHQLRREVEIQSHLRHPN-ILRLYGYFHDASRVYLILEFAPKGELYGELQRCGSFPEDRSATYIMELADALHYCHTKKVIHRDIKPENLLLGANGELKIADFG-------W-SVHTPSSRRSTLCGTLDYLPPEMIEGKTHDEKVDLWSLGVLCYEFLVGKPPFEAKTNDETYRRISRVE-YTYPAHAAISDGAKDLVAKLLKHNPMHR 409
[Close]
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000073002.1 (SMESG000073002.1)

HSP 1 Score: 682.945 bits (1761), Expect = 0.000e+0
Identity = 331/335 (98.81%), Postives = 333/335 (99.40%), Query Frame = 3 
Query: 1107 MMRINCENKLLAIPSTPQTVIEAKRVIACKCGVSIDDFYCIDLYNSDKPNDWDTYEYELMFERMRNIENINITRELASGGFGKIFICQNKFSTNNFLIKKSINETENLHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELRQTGQQMIKSQLFINSFGRFNRC 2111
            MMRINCENKLLAIPSTPQTVIEAKRVIACKCGVSIDDFYCIDLYNSDKPNDWDTYEYELMFERMRNIENINITRELASGGFG+IFICQNKFSTNNFLIKKSINETENLHREIFIN QFFYSDKLFKISGLIRNENHP LAMPYFPGGSLASYIEQ+RCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELRQTGQQMIKSQLFINSFGRFNRC
Sbjct:    1 MMRINCENKLLAIPSTPQTVIEAKRVIACKCGVSIDDFYCIDLYNSDKPNDWDTYEYELMFERMRNIENINITRELASGGFGRIFICQNKFSTNNFLIKKSINETENLHREIFINLQFFYSDKLFKISGLIRNENHPCLAMPYFPGGSLASYIEQIRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELRQTGQQMIKSQLFINSFGRFNRC 335
[Close]
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000072984.1 (SMESG000072984.1)

HSP 1 Score: 653.67 bits (1685), Expect = 0.000e+0
Identity = 322/322 (100.00%), Postives = 322/322 (100.00%), Query Frame = 3 
Query:   54 MQLIVINGESCSEKIEVEIEEFAFVADIKDKFDEILSGHGKYKSEYFILIYKNMVLNDDYIKLYNFHDHDEIWFGKIENYLTNEDCIAEIFIAARTLDIIYIIVKLNDSISAIRLILAKVYSEITNLWDCKGREIKNNEIVKDIYTSGLFKIFASCGDLSFEDCCCQHDQFKCKSYLYNWSANIIQETTRAKVINRMNKIRKLLTSSNYEFNSRFNENLLNFPLSFVNSNILFRDVIGYYIWEICENFWKLIENPYNHFERIQLRLYCHASILVALSEYSVARQHHPENTDKSINDIIIDALDYFVTLLAYLDEDWKFTAKK 1019
            MQLIVINGESCSEKIEVEIEEFAFVADIKDKFDEILSGHGKYKSEYFILIYKNMVLNDDYIKLYNFHDHDEIWFGKIENYLTNEDCIAEIFIAARTLDIIYIIVKLNDSISAIRLILAKVYSEITNLWDCKGREIKNNEIVKDIYTSGLFKIFASCGDLSFEDCCCQHDQFKCKSYLYNWSANIIQETTRAKVINRMNKIRKLLTSSNYEFNSRFNENLLNFPLSFVNSNILFRDVIGYYIWEICENFWKLIENPYNHFERIQLRLYCHASILVALSEYSVARQHHPENTDKSINDIIIDALDYFVTLLAYLDEDWKFTAKK
Sbjct:    1 MQLIVINGESCSEKIEVEIEEFAFVADIKDKFDEILSGHGKYKSEYFILIYKNMVLNDDYIKLYNFHDHDEIWFGKIENYLTNEDCIAEIFIAARTLDIIYIIVKLNDSISAIRLILAKVYSEITNLWDCKGREIKNNEIVKDIYTSGLFKIFASCGDLSFEDCCCQHDQFKCKSYLYNWSANIIQETTRAKVINRMNKIRKLLTSSNYEFNSRFNENLLNFPLSFVNSNILFRDVIGYYIWEICENFWKLIENPYNHFERIQLRLYCHASILVALSEYSVARQHHPENTDKSINDIIIDALDYFVTLLAYLDEDWKFTAKK 322
[Close]
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000073002.1 (SMESG000073002.1)

HSP 1 Score: 607.831 bits (1566), Expect = 0.000e+0
Identity = 304/335 (90.75%), Postives = 307/335 (91.64%), Query Frame = 3 
Query: 1107 MMRINCENKLLAIPSTPQTVIEAKRVIACKCGVSIDDFYCIDLYNSDKPNDWDTYEYELMFERMRNIENINITRELASGGFGKIFICQNKFSTNNFLIKKSINETENLHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELRQTGQQMIKSQLFINSFGRFNRC 2111
            MMRINCENKLLAIPSTPQTVIEAKRVIACKCGVSIDDFYCIDLYNSDKPNDWDTYEYELMFERMRN   +   R    G   K      +F    F   KSINETENLHREIFIN QFFYSDKLFKISGLIRNENHP LAMPYFPGGSLASYIEQ+RCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELRQTGQQMIKSQLFINSFGRFNRC
Sbjct:    1 MMRINCENKLLAIPSTPQTVIEAKRVIACKCGVSIDDFYCIDLYNSDKPNDWDTYEYELMFERMRNFIVVVSRRRGQPGRKQK----AKEFVEFCF---KSINETENLHREIFINLQFFYSDKLFKISGLIRNENHPCLAMPYFPGGSLASYIEQIRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELRQTGQQMIKSQLFINSFGRFNRC 328
[Close]
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000073002.1 (SMESG000073002.1)

HSP 1 Score: 605.134 bits (1559), Expect = 0.000e+0
Identity = 303/334 (90.72%), Postives = 306/334 (91.62%), Query Frame = 3 
Query: 1110 MRINCENKLLAIPSTPQTVIEAKRVIACKCGVSIDDFYCIDLYNSDKPNDWDTYEYELMFERMRNIENINITRELASGGFGKIFICQNKFSTNNFLIKKSINETENLHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELRQTGQQMIKSQLFINSFGRFNRC 2111
            MRINCENKLLAIPSTPQTVIEAKRVIACKCGVSIDDFYCIDLYNSDKPNDWDTYEYELMFERMRN   +   R    G   K      +F    F   KSINETENLHREIFIN QFFYSDKLFKISGLIRNENHP LAMPYFPGGSLASYIEQ+RCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELRQTGQQMIKSQLFINSFGRFNRC
Sbjct:    1 MRINCENKLLAIPSTPQTVIEAKRVIACKCGVSIDDFYCIDLYNSDKPNDWDTYEYELMFERMRNFIVVVSRRRGQPGRKQK----AKEFVEFCF---KSINETENLHREIFINLQFFYSDKLFKISGLIRNENHPCLAMPYFPGGSLASYIEQIRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELRQTGQQMIKSQLFINSFGRFNRC 327
[Close]
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000024532.1 (SMESG000024532.1)

HSP 1 Score: 523.857 bits (1348), Expect = 2.565e-177
Identity = 302/691 (43.70%), Postives = 431/691 (62.37%), Query Frame = 3 
Query:   54 MQLIVINGESCSEKIEVEIEEFAFVADIKDKFDEILSGHGKYKSEYFILIYKNMVLNDDYIKLYNFHDHDEIWFGKIENYLTNEDCIAEIFIAARTLDIIYIIVKLNDSISAIRLILAKVYSEITNLWDCKGREIKNNEIVKDIYTSGLFKIFASCGD-----LSFEDCCCQHDQFKCKSYLYNWSANIIQETTRAKVINRMNKIRKLLTSSNYEFNSRFNENLLNFPLSFVNSNILFRDVIGYYIWEICENFWKLIENP-----YNHFERIQLRLYCHASILVALSEYSVARQHHPENTDKSINDIIIDALDYFVTLLAYLDEDWKFTAKKLLFPCLLISYSSFEFDKFFDQCNSD--KSFVMMRINCENKLLAIPSTPQTVIEAKRVIACKCGVSIDDFYCIDLYNSDKPNDWDTY-EYELMFERMRNIENINITRELASGGFGKIFICQNKFSTNNFLIKKSINETENLHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSLASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKKNAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKIDIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMKLLIGSCLKANPELRQTGQQMIKSQLFIN 2087
            M++ V+NGE+ S K  +EI++ ++V DIK K D+IL+G GK++ E+   IYKN++L+D+YIK Y   + DEIWFGKIENYL ++D I E+F+A  +  +I++IVK+N SI+ IR ++  V S++ N++D  GRE++N +IV DI   G +++  S  D     LSFEDC  QHD+F  +  L   S    ++ T    +N +NKIR ++ S N   ++R  ENL N P   VNS +LF   I   I +IC+ FWK  ++      YN  +  +L      SILVAL +YS +RQ  PEN DKS N I+IDALDY V  L    +D K+  K      LL+     E+ +  ++ +S      ++ + +     L +  T  TV++AK  IA K GVSI D YCI+ +N DK  +   Y E   MFE ++++EN+N+ +E  +GGFG++F  Q+  S     +K + ++  +L+R+IFI++    + +LFK SGL + ++  Y+AMPY  GGSL SYI+  + L EKE   I YQIL+QI +LH L IIHRDIKPDNIVFD   NAKLIDFGL+K M    +++ LE LK+Y PGT+ YMAPE+++  PYS KIDIWSFGMV+VEMVTG PPF   A  + ++EL+K+  Y+FK    IS ++   I SCL  NP  R + QQ+I SQ  I 
Sbjct:    1 MKISVVNGENLSVKFVIEIDKHSYVGDIKHKIDKILNGQGKWEKEHLRFIYKNIILHDEYIKRYKVCESDEIWFGKIENYLRSDDVIIEVFLAGCSPVLIWLIVKINHSITVIRSMIEIVQSKLINIYDWNGREMQNVQIVSDIDPIGYYRLIVSYEDERGKWLSFEDCVRQHDEFTFRFCLN--SEFEFEDMTEINTVNLINKIRTIM-SLNDVIDARLKENLSNIPSGVVNSKLLFYYNIQLRILDICQEFWKSTKDSPYYINYNIIKSFEL------SILVALHQYSHSRQKDPENKDKSFNGIVIDALDYLVKHLHDHCKDLKYHQKLFFDHFLLVPRPVSEYIELRNEYSSQLITKIIINKKDNIAPFLTLLLTQGTVLDAKCEIAQKLGVSIKDLYCINHWNHDKAEEDKIYKEGFYMFEIIKSMENMNLGKEFGAGGFGRVFFYQDIISGKQLAMKTANSDKSSLYRDIFISALIMNNSELFKYSGLFKYKSELYIAMPYMTGGSLTSYIQGKKGLFEKEALRISYQILIQIEKLHELKIIHRDIKPDNIVFDGAGNAKLIDFGLSKWMKNSTDENILEKLKAYAPGTINYMAPEILREIPYSYKIDIWSFGMVLVEMVTGNPPFHKKAPARAIIELKKMVEYKFKPSVLISIELHQFIKSCLIVNPNERPSAQQLIGSQFIIG 682
The following BLAST results are available for this feature:
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CHEK19.333e-2731.22checkpoint kinase 1 [Source:HGNC Symbol;Acc:HGNC:1... [more]
PNCK1.216e-2528.22pregnancy up-regulated nonubiquitous CaM kinase [S... [more]
PNCK1.216e-2528.22pregnancy up-regulated nonubiquitous CaM kinase [S... [more]
CHEK11.635e-2531.25checkpoint kinase 1 [Source:HGNC Symbol;Acc:HGNC:1... [more]
CHEK11.815e-2531.25checkpoint kinase 1 [Source:HGNC Symbol;Acc:HGNC:1... [more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
unc-821.124e-2530.16pep chromosome:WBcel235:IV:7424498:7444660:1 gene:... [more]
unc-821.474e-2530.16pep chromosome:WBcel235:IV:7428926:7444648:1 gene:... [more]
unc-821.490e-2530.16pep chromosome:WBcel235:IV:7428926:7444648:1 gene:... [more]
unc-821.766e-2530.16pep chromosome:WBcel235:IV:7428926:7444648:1 gene:... [more]
unc-821.901e-2530.16pep chromosome:WBcel235:IV:7431348:7444648:1 gene:... [more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
PhKgamma8.126e-2632.64gene:FBgn0011754 transcript:FBtr0343587[more]
PhKgamma1.947e-2532.90gene:FBgn0011754 transcript:FBtr0090002[more]
PhKgamma1.947e-2532.90gene:FBgn0011754 transcript:FBtr0343648[more]
PhKgamma8.163e-2532.90gene:FBgn0011754 transcript:FBtr0301501[more]
PhKgamma8.163e-2532.90gene:FBgn0011754 transcript:FBtr0301500[more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
camk1a4.507e-2729.28calcium/calmodulin-dependent protein kinase Ia [So... [more]
camk1a4.652e-2729.28calcium/calmodulin-dependent protein kinase Ia [So... [more]
camk1a4.652e-2729.28calcium/calmodulin-dependent protein kinase Ia [So... [more]
stk24a1.653e-2529.84serine/threonine kinase 24a (STE20 homolog, yeast)... [more]
hunk4.988e-2536.20hormonally up-regulated Neu-associated kinase [Sou... [more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
numbl7.565e-2527.84numb homolog-like [Source:Xenbase;Acc:XB-GENE-9617... [more]
bnc23.097e-2429.33basonuclin 2 [Source:Xenbase;Acc:XB-GENE-953157][more]
exosc46.309e-2428.41exosome component 4 [Source:Xenbase;Acc:XB-GENE-96... [more]
stk106.564e-2430.94serine/threonine kinase 10 [Source:NCBI gene;Acc:7... [more]
stk107.772e-2431.06serine/threonine kinase 10 [Source:NCBI gene;Acc:7... [more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Gm49225.657e-2729.17predicted gene 4922 [Source:MGI Symbol;Acc:MGI:364... [more]
Gm49225.657e-2729.17predicted gene 4922 [Source:MGI Symbol;Acc:MGI:364... [more]
Pnck2.417e-2628.22pregnancy upregulated non-ubiquitously expressed C... [more]
Pnck2.417e-2628.22pregnancy upregulated non-ubiquitously expressed C... [more]
Pnck2.417e-2628.22pregnancy upregulated non-ubiquitously expressed C... [more]
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BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q10056|SHK2_SCHPO3.463e-2628.15Serine/threonine-protein kinase shk2 OS=Schizosacc... [more]
sp|Q8C0N0|SMKZ_MOUSE3.957e-2629.17Sperm motility kinase Z OS=Mus musculus OX=10090 G... [more]
sp|Q9QYK9|KCC1B_MOUSE1.691e-2528.22Calcium/calmodulin-dependent protein kinase type 1... [more]
sp|Q5APR8|CLA4_CANAL1.810e-2527.72Serine/threonine-protein kinase CLA4 OS=Candida al... [more]
sp|O14427|CLA4_CANAX2.239e-2527.72Serine/threonine-protein kinase CLA4 OS=Candida al... [more]
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BLAST of Protein kinase domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0BFM24.608e-3334.27Protein kinase domain-containing protein OS=Parame... [more]
A0BZI14.184e-3133.85Protein kinase domain-containing protein OS=Parame... [more]
A0BWA18.215e-3134.01Protein kinase domain-containing protein OS=Parame... [more]
T2M6M62.736e-2831.44Mitogen-activated protein kinase kinase kinase 3 O... [more]
G0R2T05.072e-2833.74Protein kinase domain protein OS=Ichthyophthirius ... [more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
hunk5.760e-2830.22hormonally up-regulated Neu-associated kinase [Sou... [more]
camk1ga1.668e-2529.70calcium/calmodulin-dependent protein kinase IGa [S... [more]
stk101.699e-2430.71serine/threonine-protein kinase 10 [Source:NCBI ge... [more]
pak6a2.691e-2429.12p21 (RAC1) activated kinase 6 [Source:NCBI gene;Ac... [more]
pak12.729e-2426.24p21 protein (Cdc42/Rac)-activated kinase 1 [Source... [more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
aurka6.590e-2527.73aurora kinase A [Source:ZFIN;Acc:ZDB-GENE-040801-1... [more]
ENSPMAT00000004683.11.797e-2436.69pep scaffold:Pmarinus_7.0:GL488517:199:5283:1 gene... [more]
slka3.558e-2331.15STE20-like kinase a [Source:ZFIN;Acc:ZDB-GENE-0504... [more]
pak45.960e-2226.15p21 protein (Cdc42/Rac)-activated kinase 4 [Source... [more]
map3k26.174e-2232.71mitogen-activated protein kinase kinase kinase 2 [... [more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5
Match NameE-valueIdentityDescription
YPL150W_mRNA7.516e-2730.60Protein kinase of unknown cellular role; binds pho... [more]
MKK25.990e-2630.45MAPKK involved in the protein kinase C signaling p... [more]
BCK11.365e-2427.78MAPKKK acting in the protein kinase C signaling pa... [more]
MKK11.749e-2431.58MAPKK involved in the protein kinase C signaling p... [more]
STE114.424e-2441.86Signal transducing MEK kinase; involved in pheromo... [more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO414102.680e-3131.09Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO458467.187e-2726.46Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO487411.207e-2530.66Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO354371.557e-2527.06Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO362531.619e-2528.24Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
camk1gb5.748e-2728.52calcium/calmodulin-dependent protein kinase type 1... [more]
hunk7.225e-2734.56hormonally up-regulated Neu-associated kinase [Sou... [more]
chek12.356e-2629.63checkpoint kinase 1 [Source:NCBI gene;Acc:10117078... [more]
pak6a2.533e-2428.74p21 (RAC1) activated kinase 6 [Source:NCBI gene;Ac... [more]
aurka3.099e-2426.15aurora kinase A [Source:NCBI gene;Acc:101165631][more]
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BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000073002.10.000e+098.81SMESG000073002.1[more]
SMESG000072984.10.000e+0100.00SMESG000072984.1[more]
SMESG000073002.10.000e+090.75SMESG000073002.1[more]
SMESG000073002.10.000e+090.72SMESG000073002.1[more]
SMESG000024532.12.565e-17743.70SMESG000024532.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30031142 ID=SMED30031142|Name=Protein kinase domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=2222bp
TATCTTATTTTTATAAATTTGTTTTAGTTAGATTGTAGTATCAAAATATT
AAAATGCAATTGATAGTGATAAATGGTGAAAGTTGTAGTGAAAAAATAGA
AGTTGAAATAGAAGAATTCGCATTCGTAGCAGATATAAAAGATAAATTTG
ATGAAATTCTTAGTGGACATGGAAAATATAAGTCAGAATACTTTATATTA
ATTTACAAAAATATGGTTTTAAACGATGACTATATTAAGCTATACAATTT
TCATGATCATGATGAAATCTGGTTTGGTAAAATTGAAAATTATTTGACAA
ATGAGGATTGTATTGCAGAGATTTTTATAGCAGCACGGACACTTGATATT
ATATATATAATAGTAAAATTAAATGATTCGATATCAGCGATCAGATTAAT
ATTAGCAAAAGTTTATTCTGAAATTACAAATTTGTGGGATTGTAAAGGTC
GAGAAATTAAAAATAATGAAATAGTTAAAGATATATATACGAGTGGATTA
TTTAAAATTTTTGCGAGCTGTGGCGATTTGTCTTTCGAAGATTGCTGCTG
TCAGCACGATCAATTCAAATGCAAATCTTACTTATATAATTGGTCAGCTA
ATATTATCCAAGAAACAACAAGAGCGAAAGTAATAAATCGAATGAATAAA
ATCAGGAAGTTGCTCACCTCATCAAATTACGAATTCAATTCCAGATTTAA
CGAAAATTTATTGAATTTTCCGTTGTCATTTGTCAATTCAAATATTCTAT
TTCGTGACGTCATTGGCTATTACATCTGGGAGATTTGTGAGAATTTTTGG
AAATTGATTGAAAATCCATATAATCATTTCGAGCGTATCCAGTTGAGATT
GTATTGCCACGCATCTATATTAGTTGCTTTATCTGAATATAGTGTTGCTA
GGCAACATCACCCAGAAAATACCGATAAATCAATAAATGACATTATAATC
GATGCTTTGGATTATTTTGTCACGCTTTTAGCCTATCTTGACGAAGATTG
GAAATTCACTGCAAAAAAATTACTTTTTCCATGTTTATTAATATCTTATT
CCAGTTTTGAATTTGATAAATTTTTTGATCAATGTAATTCTGACAAATCT
TTTGTCATGATGAGAATAAATTGTGAGAATAAATTATTAGCTATTCCATC
CACTCCTCAAACTGTTATCGAAGCCAAGAGAGTCATTGCTTGCAAATGTG
GAGTGAGCATTGATGATTTCTATTGTATCGATCTTTATAATAGTGACAAA
CCAAATGATTGGGATACATATGAATATGAGTTAATGTTTGAACGGATGAG
AAACATTGAAAATATAAATATCACAAGAGAATTGGCAAGTGGAGGATTTG
GGAAAATTTTTATTTGTCAAAATAAATTTTCTACAAATAATTTTCTCATA
AAGAAGTCCATTAATGAAACAGAAAATCTTCATCGAGAAATTTTCATTAA
TTCGCAATTCTTTTACTCAGACAAACTGTTCAAAATTTCAGGTTTAATCA
GAAATGAAAATCATCCCTACCTTGCTATGCCATACTTCCCAGGAGGCTCT
CTCGCTTCATACATCGAACAAGTAAGATGTTTAGATGAAAAAGAAATTGG
AAACATTTTGTATCAAATTCTCATGCAAATAAACGAGTTGCATCGATTGG
GAATAATACATCGTGACATCAAACCTGATAATATTGTTTTTGATGAAAAG
AAAAATGCAAAATTAATAGATTTTGGGCTAGCCAAGTGTATGGACGAATG
GAAAAATAAAGATCAATTAGAAAATTTGAAATCTTATGTTCCAGGAACAG
TTAAATATATGGCGCCAGAATTGGTAAAAGGATCTCCTTATTCTAACAAA
ATCGATATTTGGTCTTTTGGGATGGTAATTGTTGAGATGGTTACAGGTAA
ACCTCCGTTTCCTGGGATGGCAATTGGCAAAATACTGTTGGAACTTAGAA
AATTGGAAACCTATAGATTCAAATCAATTAAACAGATTTCCAATGACATG
AAACTGTTAATCGGTTCATGTTTGAAAGCGAATCCGGAATTGAGACAAAC
TGGCCAGCAAATGATCAAATCTCAATTATTTATTAATAGTTTTGGCAGGT
TTAATAGATGTTAATAATTATCAGTCTAATAGTTATGTCAAAATACAGTA
ACTTCCGCTTATAGTAAAACACCATCTGCCATAAAAAAATTTTGACTATA
ACTTGATTATACTATAAGTGAT
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protein sequence of SMED30031142-orf-1

>SMED30031142-orf-1 ID=SMED30031142-orf-1|Name=SMED30031142-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=687bp
MQLIVINGESCSEKIEVEIEEFAFVADIKDKFDEILSGHGKYKSEYFILI
YKNMVLNDDYIKLYNFHDHDEIWFGKIENYLTNEDCIAEIFIAARTLDII
YIIVKLNDSISAIRLILAKVYSEITNLWDCKGREIKNNEIVKDIYTSGLF
KIFASCGDLSFEDCCCQHDQFKCKSYLYNWSANIIQETTRAKVINRMNKI
RKLLTSSNYEFNSRFNENLLNFPLSFVNSNILFRDVIGYYIWEICENFWK
LIENPYNHFERIQLRLYCHASILVALSEYSVARQHHPENTDKSINDIIID
ALDYFVTLLAYLDEDWKFTAKKLLFPCLLISYSSFEFDKFFDQCNSDKSF
VMMRINCENKLLAIPSTPQTVIEAKRVIACKCGVSIDDFYCIDLYNSDKP
NDWDTYEYELMFERMRNIENINITRELASGGFGKIFICQNKFSTNNFLIK
KSINETENLHREIFINSQFFYSDKLFKISGLIRNENHPYLAMPYFPGGSL
ASYIEQVRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVFDEKK
NAKLIDFGLAKCMDEWKNKDQLENLKSYVPGTVKYMAPELVKGSPYSNKI
DIWSFGMVIVEMVTGKPPFPGMAIGKILLELRKLETYRFKSIKQISNDMK
LLIGSCLKANPELRQTGQQMIKSQLFINSFGRFNRC*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: biological process
TermDefinition
GO:0035404histone-serine phosphorylation
GO:0006468protein phosphorylation
GO:0016310phosphorylation
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000099neuron
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR000719Prot_kinase_dom
IPR008271Ser/Thr_kinase_AS
IPR011009Kinase-like_dom_sf
Vocabulary: molecular function
TermDefinition
GO:0005524ATP binding
GO:0004672protein kinase activity
GO:0004674protein serine/threonine kinase activity
GO:0016301kinase activity
GO:0016740transferase activity
GO:0000166nucleotide binding
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000719Protein kinase domainSMARTSM00220serkin_6coord: 421..676
e-value: 2.4E-57
score: 206.5
IPR000719Protein kinase domainPFAMPF00069Pkinasecoord: 424..676
e-value: 4.7E-53
score: 180.2
IPR000719Protein kinase domainPROSITEPS50011PROTEIN_KINASE_DOMcoord: 421..677
score: 41.206
NoneNo IPR availableGENE3DG3DSA:1.10.510.10coord: 413..684
e-value: 2.2E-62
score: 213.1
NoneNo IPR availablePANTHERPTHR24347SERINE/THREONINE-PROTEIN KINASEcoord: 412..678
NoneNo IPR availablePANTHERPTHR24347:SF412CALCIUM/CALMODULIN DEPENDENT PROTEIN KINASE Icoord: 412..678
NoneNo IPR availableCDDcd14014STKc_PknB_likecoord: 423..671
e-value: 5.99536E-47
score: 165.067
IPR008271Serine/threonine-protein kinase, active sitePROSITEPS00108PROTEIN_KINASE_STcoord: 534..546
IPR011009Protein kinase-like domain superfamilySUPERFAMILYSSF56112Protein kinase-like (PK-like)coord: 409..678