Ribosomal protein S6 kinase
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30031106 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 8
Homology
BLAST of Ribosomal protein S6 kinase vs. Ensembl Human
Match: RPS6KB1 (ribosomal protein S6 kinase B1 [Source:HGNC Symbol;Acc:HGNC:10436]) HSP 1 Score: 350.517 bits (898), Expect = 2.084e-115 Identity = 191/357 (53.50%), Postives = 243/357 (68.07%), Query Frame = 1
Query: 205 DICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP--TTTDDSNCYWFENFSYVSPQVYLELSENGSF 1266
+I E +VN K+ F+LL+ LGKGGYG+VF +KV GA G+ FAMKV+KKA ++ N K DT + ERNILE V HPF+V L +AFQT L+L+LEYL+GGELFMQLER+ ED A FYLAE ++ALGHLH G+IYRDLK EN+ML+ GHVKLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +VDWWS+G L+YDML G PF G NR + I K+ KL +P +LT + LLK LL +N +RLG G D E++ H FFR INW++ LAR+++PPF P L S +DVS FD + + SP +T +S F F+YV+P V + E SF
Sbjct: 73 EISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAK-DTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSF 428
BLAST of Ribosomal protein S6 kinase vs. Ensembl Human
Match: RPS6KB1 (ribosomal protein S6 kinase B1 [Source:HGNC Symbol;Acc:HGNC:10436]) HSP 1 Score: 351.288 bits (900), Expect = 2.498e-115 Identity = 191/357 (53.50%), Postives = 243/357 (68.07%), Query Frame = 1
Query: 205 DICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP--TTTDDSNCYWFENFSYVSPQVYLELSENGSF 1266
+I E +VN K+ F+LL+ LGKGGYG+VF +KV GA G+ FAMKV+KKA ++ N K DT + ERNILE V HPF+V L +AFQT L+L+LEYL+GGELFMQLER+ ED A FYLAE ++ALGHLH G+IYRDLK EN+ML+ GHVKLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +VDWWS+G L+YDML G PF G NR + I K+ KL +P +LT + LLK LL +N +RLG G D E++ H FFR INW++ LAR+++PPF P L S +DVS FD + + SP +T +S F F+YV+P V + E SF
Sbjct: 20 EISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAK-DTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSF 375
BLAST of Ribosomal protein S6 kinase vs. Ensembl Human
Match: RPS6KB1 (ribosomal protein S6 kinase B1 [Source:HGNC Symbol;Acc:HGNC:10436]) HSP 1 Score: 350.903 bits (899), Expect = 1.444e-114 Identity = 191/357 (53.50%), Postives = 243/357 (68.07%), Query Frame = 1
Query: 205 DICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP--TTTDDSNCYWFENFSYVSPQVYLELSENGSF 1266
+I E +VN K+ F+LL+ LGKGGYG+VF +KV GA G+ FAMKV+KKA ++ N K DT + ERNILE V HPF+V L +AFQT L+L+LEYL+GGELFMQLER+ ED A FYLAE ++ALGHLH G+IYRDLK EN+ML+ GHVKLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +VDWWS+G L+YDML G PF G NR + I K+ KL +P +LT + LLK LL +N +RLG G D E++ H FFR INW++ LAR+++PPF P L S +DVS FD + + SP +T +S F F+YV+P V + E SF
Sbjct: 73 EISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAK-DTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSF 428
BLAST of Ribosomal protein S6 kinase vs. Ensembl Human
Match: RPS6KB2 (ribosomal protein S6 kinase B2 [Source:HGNC Symbol;Acc:HGNC:10437]) HSP 1 Score: 337.806 bits (865), Expect = 5.939e-110 Identity = 182/358 (50.84%), Postives = 240/358 (67.04%), Query Frame = 1
Query: 202 VDICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP--TTTDDSNCYWFENFSYVSPQVYLELSENGSF 1266
V++ E +VN ++ H F+LL+ LGKGGYG+VF +KV G G+ +AMKV++KA+++ N K DT + ERNILE+V HPF+V+L +AFQT L+L+LE L+GGELF LER+ ED A FYLAE TLALGHLHS G+IYRDLK EN+ML GH+KLTDFGL KE ++ +TH+FCGT+EYMAPEIL R GH +VDWWS+G L+YDML G+ PF NR + + K+ KL +P +LT + L+K L +NP R+GGG D +++RH FFR +NWD LA + PPF P L S +DVS FD + + SP T +S F F+YV+P V + E SF
Sbjct: 48 VELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAK-DTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSIKEGFSF 404
BLAST of Ribosomal protein S6 kinase vs. Ensembl Human
Match: RPS6KB1 (ribosomal protein S6 kinase B1 [Source:HGNC Symbol;Acc:HGNC:10436]) HSP 1 Score: 316.235 bits (809), Expect = 2.235e-101 Identity = 163/303 (53.80%), Postives = 206/303 (67.99%), Query Frame = 1
Query: 367 KARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP--TTTDDSNCYWFENFSYVSPQVYLELSENGSF 1266
KA ++ N K DT + ERNILE V HPF+V L +AFQT L+L+LEYL+GGELFMQLER+ ED A FYLAE ++ALGHLH G+IYRDLK EN+ML+ GHVKLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +VDWWS+G L+YDML G PF G NR + I K+ KL +P +LT + LLK LL +N +RLG G D E++ H FFR INW++ LAR+++PPF P L S +DVS FD + + SP +T +S F F+YV+P V + E SF
Sbjct: 104 KAMIVRNAK-DTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSF 405
BLAST of Ribosomal protein S6 kinase vs. Ensembl Celegans
Match: rsks-1 (Ribosomal protein S6 kinase beta [Source:UniProtKB/Swiss-Prot;Acc:Q9NAH6]) HSP 1 Score: 340.117 bits (871), Expect = 1.774e-110 Identity = 178/365 (48.77%), Postives = 242/365 (66.30%), Query Frame = 1
Query: 184 DSTSKSVDICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNI-----VSEPCMISPTTTDDSNCYWFENFSYVSPQVYLELSENG 1260
D +S+ +C +NPP V+V DF LLK LGKGGYG+VF +K G+ G+ FAMKV++KA ++ N+K DT + ERNILEAV PF+ L +AFQT L+L+LEYL+GGELFM LER+ E+ A+FYL+E ++L HLH G+IYRDLK EN++LD YGHVKLTDFGL KE D+ TH+FCGT+EYMAPEIL R GHG +VDWWS+G L++DML G PF NR + I K+ +L +P +L++ + L+K LL ++ RLG G D EEIK H FF++ +W+ AR+L+ PF P + + +D SLFD V PC + + D+ F F+YV+P V +++ G
Sbjct: 58 DPMMESIQLCASAINPPNVRVGPEDFQLLKVLGKGGYGKVFQVRKTTGSDNGQIFAMKVLQKATIVRNQK-DTAHTKAERNILEAVKSPFICDLLYAFQTGGKLYLILEYLSGGELFMHLEREGMFMENVAKFYLSEIVVSLEHLHQQGIIYRDLKPENILLDAYGHVKLTDFGLCKEEIEGDQKTHTFCGTIEYMAPEILMRCGHGKAVDWWSLGALMFDMLTGGPPFTAENRRKTIDKILKGRLTLPAYLSNEARDLIKKLLKRHVDTRLGAGLSDAEEIKSHAFFKTTDWNLVYARQLEAPFKPNIENDEDTSLFDARFTKMTPVDSPCETNFSLNGDNP---FVGFTYVAPSVLEMMNKGG 418
BLAST of Ribosomal protein S6 kinase vs. Ensembl Celegans
Match: rskn-1 (Putative ribosomal protein S6 kinase alpha-1 [Source:UniProtKB/Swiss-Prot;Acc:Q21734]) HSP 1 Score: 311.997 bits (798), Expect = 1.415e-97 Identity = 173/361 (47.92%), Postives = 241/361 (66.76%), Query Frame = 1
Query: 172 KDEYDSTSKS-VDICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKERNDDE-LTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISPTTTDDSNCY-WFENFSYVSPQVYLE 1245
+++ DS+S++ +DI + V G K F+LLK LG+G +G+VFL +KV G +G +AMKV+KKA L + TK ERNIL ++HPF+VKL++AFQT L+L+L++L GG+LF +L ++ TED+ +FYLAE TLAL HLHS+G++YRDLK EN++LD GH+K+TDFGLSKE D E T+SFCGTVEYMAPE++ RRGH + D+WS+G+L+++ML G+ PF G +R+ + ++ AKL +P FLT + LL+ L +N + RLG G VEEIKRH FF I++ K L +E+ PPF P LS+ D S FD SP +N + F FS+VS V E
Sbjct: 19 EEKTDSSSETEIDIGD--VRKCGEKADPRQFELLKVLGQGSFGKVFLVRKVRGRDSGHVYAMKVLKKATLKVRDRQRTKL---ERNILAHISHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEDDVKFYLAELTLALEHLHSLGIVYRDLKPENILLDADGHIKVTDFGLSKEAIDSEKKTYSFCGTVEYMAPEVINRRGHSMAADFWSLGVLMFEMLTGHLPFQGRDRNDTMTQILKAKLSMPHFLTQEAQSLLRALFKRNSQNRLGAGPDGVEEIKRHAFFAKIDFVKLLNKEIDPPFKPALSTVDSTSYFDPEFTKRTPKDSPALPASANGHEIFRGFSFVSNAVMEE 374 HSP 2 Score: 105.145 bits (261), Expect = 1.739e-23 Identity = 61/202 (30.20%), Postives = 115/202 (56.93%), Query Frame = 1
Query: 346 FAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTL-TEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRY----GHVKLTDFGLSKE-RNDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGG---NRSQVIQKVTNAKLKI 924
+A+K+VKKA ++ D +L +H F+VKL+ ++ +++++ E GGEL +L + +L +E E +A A+ +LHS V +RDL + N++ +++ DFG +K+ R ++ + + C T +++APE+L+++G+ S D WS+G+LL+ ML G +PF G Q++Q+V + K+ +
Sbjct: 423 YAVKIVKKAVFDATEEVDI--------LLRHSHHQFVVKLFDVYEDETAIYMIEELCEGGELLDKLVNKKSLGSEKEVAAIMANLLNAVQYLHSQQVAHRDLTAANILFALKDGDPSSLRIVDFGFAKQSRAENGMLMTPCYTAQFVAPEVLRKQGYDRSCDVWSLGVLLHTMLTGCTPFAMGPNDTPDQILQRVGDGKISM 616
BLAST of Ribosomal protein S6 kinase vs. Ensembl Celegans
Match: rskn-1 (Putative ribosomal protein S6 kinase alpha-1 [Source:UniProtKB/Swiss-Prot;Acc:Q21734]) HSP 1 Score: 310.842 bits (795), Expect = 3.743e-97 Identity = 177/376 (47.07%), Postives = 246/376 (65.43%), Query Frame = 1
Query: 127 INGIELEANDSDNLNKDEYDSTSKS-VDICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKERNDDE-LTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISPTTTDDSNCY-WFENFSYVSPQVYLE 1245
I+ I+ N+ L + DS+S++ +DI + V G K F+LLK LG+G +G+VFL +KV G +G +AMKV+KKA L + TK ERNIL ++HPF+VKL++AFQT L+L+L++L GG+LF +L ++ TED+ +FYLAE TLAL HLHS+G++YRDLK EN++LD GH+K+TDFGLSKE D E T+SFCGTVEYMAPE++ RRGH + D+WS+G+L+++ML G+ PF G +R+ + ++ AKL +P FLT + LL+ L +N + RLG G VEEIKRH FF I++ K L +E+ PPF P LS+ D S FD SP +N + F FS+VS V E
Sbjct: 42 IHIIQPPPNNGFRLMNWKTDSSSETEIDIGD--VRKCGEKADPRQFELLKVLGQGSFGKVFLVRKVRGRDSGHVYAMKVLKKATLKVRDRQRTKL---ERNILAHISHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEDDVKFYLAELTLALEHLHSLGIVYRDLKPENILLDADGHIKVTDFGLSKEAIDSEKKTYSFCGTVEYMAPEVINRRGHSMAADFWSLGVLMFEMLTGHLPFQGRDRNDTMTQILKAKLSMPHFLTQEAQSLLRALFKRNSQNRLGAGPDGVEEIKRHAFFAKIDFVKLLNKEIDPPFKPALSTVDSTSYFDPEFTKRTPKDSPALPASANGHEIFRGFSFVSNAVMEE 412 HSP 2 Score: 104.76 bits (260), Expect = 2.401e-23 Identity = 61/202 (30.20%), Postives = 115/202 (56.93%), Query Frame = 1
Query: 346 FAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTL-TEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRY----GHVKLTDFGLSKE-RNDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGG---NRSQVIQKVTNAKLKI 924
+A+K+VKKA ++ D +L +H F+VKL+ ++ +++++ E GGEL +L + +L +E E +A A+ +LHS V +RDL + N++ +++ DFG +K+ R ++ + + C T +++APE+L+++G+ S D WS+G+LL+ ML G +PF G Q++Q+V + K+ +
Sbjct: 461 YAVKIVKKAVFDATEEVDI--------LLRHSHHQFVVKLFDVYEDETAIYMIEELCEGGELLDKLVNKKSLGSEKEVAAIMANLLNAVQYLHSQQVAHRDLTAANILFALKDGDPSSLRIVDFGFAKQSRAENGMLMTPCYTAQFVAPEVLRKQGYDRSCDVWSLGVLLHTMLTGCTPFAMGPNDTPDQILQRVGDGKISM 654
BLAST of Ribosomal protein S6 kinase vs. Ensembl Celegans
Match: rskn-1 (Putative ribosomal protein S6 kinase alpha-1 [Source:UniProtKB/Swiss-Prot;Acc:Q21734]) HSP 1 Score: 310.842 bits (795), Expect = 5.161e-97 Identity = 173/357 (48.46%), Postives = 238/357 (66.67%), Query Frame = 1
Query: 184 DSTSKS-VDICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKERNDDE-LTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISPTTTDDSNCY-WFENFSYVSPQVYLE 1245
DS+S++ +DI + V G K F+LLK LG+G +G+VFL +KV G +G +AMKV+KKA L + TK ERNIL ++HPF+VKL++AFQT L+L+L++L GG+LF +L ++ TED+ +FYLAE TLAL HLHS+G++YRDLK EN++LD GH+K+TDFGLSKE D E T+SFCGTVEYMAPE++ RRGH + D+WS+G+L+++ML G+ PF G +R+ + ++ AKL +P FLT + LL+ L +N + RLG G VEEIKRH FF I++ K L +E+ PPF P LS+ D S FD SP +N + F FS+VS V E
Sbjct: 41 DSSSETEIDIGD--VRKCGEKADPRQFELLKVLGQGSFGKVFLVRKVRGRDSGHVYAMKVLKKATLKVRDRQRTKL---ERNILAHISHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEDDVKFYLAELTLALEHLHSLGIVYRDLKPENILLDADGHIKVTDFGLSKEAIDSEKKTYSFCGTVEYMAPEVINRRGHSMAADFWSLGVLMFEMLTGHLPFQGRDRNDTMTQILKAKLSMPHFLTQEAQSLLRALFKRNSQNRLGAGPDGVEEIKRHAFFAKIDFVKLLNKEIDPPFKPALSTVDSTSYFDPEFTKRTPKDSPALPASANGHEIFRGFSFVSNAVMEE 392 HSP 2 Score: 104.76 bits (260), Expect = 1.917e-23 Identity = 61/202 (30.20%), Postives = 115/202 (56.93%), Query Frame = 1
Query: 346 FAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTL-TEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRY----GHVKLTDFGLSKE-RNDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGG---NRSQVIQKVTNAKLKI 924
+A+K+VKKA ++ D +L +H F+VKL+ ++ +++++ E GGEL +L + +L +E E +A A+ +LHS V +RDL + N++ +++ DFG +K+ R ++ + + C T +++APE+L+++G+ S D WS+G+LL+ ML G +PF G Q++Q+V + K+ +
Sbjct: 441 YAVKIVKKAVFDATEEVDI--------LLRHSHHQFVVKLFDVYEDETAIYMIEELCEGGELLDKLVNKKSLGSEKEVAAIMANLLNAVQYLHSQQVAHRDLTAANILFALKDGDPSSLRIVDFGFAKQSRAENGMLMTPCYTAQFVAPEVLRKQGYDRSCDVWSLGVLLHTMLTGCTPFAMGPNDTPDQILQRVGDGKISM 634
BLAST of Ribosomal protein S6 kinase vs. Ensembl Celegans
Match: rskn-1 (Putative ribosomal protein S6 kinase alpha-1 [Source:UniProtKB/Swiss-Prot;Acc:Q21734]) HSP 1 Score: 311.612 bits (797), Expect = 6.293e-97 Identity = 177/376 (47.07%), Postives = 246/376 (65.43%), Query Frame = 1
Query: 127 INGIELEANDSDNLNKDEYDSTSKS-VDICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKERNDDE-LTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISPTTTDDSNCY-WFENFSYVSPQVYLE 1245
I+ I+ N+ L + DS+S++ +DI + V G K F+LLK LG+G +G+VFL +KV G +G +AMKV+KKA L + TK ERNIL ++HPF+VKL++AFQT L+L+L++L GG+LF +L ++ TED+ +FYLAE TLAL HLHS+G++YRDLK EN++LD GH+K+TDFGLSKE D E T+SFCGTVEYMAPE++ RRGH + D+WS+G+L+++ML G+ PF G +R+ + ++ AKL +P FLT + LL+ L +N + RLG G VEEIKRH FF I++ K L +E+ PPF P LS+ D S FD SP +N + F FS+VS V E
Sbjct: 61 IHIIQPPPNNGFRLMNWKTDSSSETEIDIGD--VRKCGEKADPRQFELLKVLGQGSFGKVFLVRKVRGRDSGHVYAMKVLKKATLKVRDRQRTKL---ERNILAHISHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEDDVKFYLAELTLALEHLHSLGIVYRDLKPENILLDADGHIKVTDFGLSKEAIDSEKKTYSFCGTVEYMAPEVINRRGHSMAADFWSLGVLMFEMLTGHLPFQGRDRNDTMTQILKAKLSMPHFLTQEAQSLLRALFKRNSQNRLGAGPDGVEEIKRHAFFAKIDFVKLLNKEIDPPFKPALSTVDSTSYFDPEFTKRTPKDSPALPASANGHEIFRGFSFVSNAVMEE 431 HSP 2 Score: 105.145 bits (261), Expect = 1.656e-23 Identity = 61/202 (30.20%), Postives = 115/202 (56.93%), Query Frame = 1
Query: 346 FAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTL-TEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRY----GHVKLTDFGLSKE-RNDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGG---NRSQVIQKVTNAKLKI 924
+A+K+VKKA ++ D +L +H F+VKL+ ++ +++++ E GGEL +L + +L +E E +A A+ +LHS V +RDL + N++ +++ DFG +K+ R ++ + + C T +++APE+L+++G+ S D WS+G+LL+ ML G +PF G Q++Q+V + K+ +
Sbjct: 480 YAVKIVKKAVFDATEEVDI--------LLRHSHHQFVVKLFDVYEDETAIYMIEELCEGGELLDKLVNKKSLGSEKEVAAIMANLLNAVQYLHSQQVAHRDLTAANILFALKDGDPSSLRIVDFGFAKQSRAENGMLMTPCYTAQFVAPEVLRKQGYDRSCDVWSLGVLLHTMLTGCTPFAMGPNDTPDQILQRVGDGKISM 673
BLAST of Ribosomal protein S6 kinase vs. Ensembl Fly
Match: S6k (gene:FBgn0283472 transcript:FBtr0077114) HSP 1 Score: 363.229 bits (931), Expect = 4.033e-120 Identity = 188/373 (50.40%), Postives = 253/373 (67.83%), Query Frame = 1
Query: 127 INGIELEANDSDNLNKDEYDSTSKSVDICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP--TTTDDSNCYWFENFSYVSPQV 1236
++ ++LE NL++D +++ +CEE VNP +K+ DF+L K LGKGGYG+VF +K G A +YFAMKV+KKA ++TN+K DT + ERNILEAV HPF+V+L +AFQT+ L+L+LEYL+GGELFM LER+ ED FYL+E LALGHLH +G+IYRDLK EN++LD GHVKLTDFGL KE + +TH+FCGT+EYMAPEIL R GHG +VDWWS+G L++DML G PF NR + I+ + AKL +P +LT + L++ L+ + RLG G +D ++ H FF+ +NWD LAR L+PP P L S DDVS FD + + SP TT +S F+ F+YV+P +
Sbjct: 35 LDDVDLEPELCINLHQDT--EGQETIQLCEENVNPGKIKLGPKDFELKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQK-DTAHTRAERNILEAVKHPFIVELVYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGHLHKLGIIYRDLKPENILLDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMFDMLTGVPPFTAENRKKTIETILKAKLNLPAYLTPEARDLVRRLMKRQEPQRLGSGPEDAAAVQIHPFFKHVNWDDVLARRLEPPIKPLLRSEDDVSQFDTRFTRQIPVDSPDDTTLSESANLIFQGFTYVAPSI 404
BLAST of Ribosomal protein S6 kinase vs. Ensembl Fly
Match: S6k (gene:FBgn0283472 transcript:FBtr0333264) HSP 1 Score: 363.229 bits (931), Expect = 4.033e-120 Identity = 188/373 (50.40%), Postives = 253/373 (67.83%), Query Frame = 1
Query: 127 INGIELEANDSDNLNKDEYDSTSKSVDICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP--TTTDDSNCYWFENFSYVSPQV 1236
++ ++LE NL++D +++ +CEE VNP +K+ DF+L K LGKGGYG+VF +K G A +YFAMKV+KKA ++TN+K DT + ERNILEAV HPF+V+L +AFQT+ L+L+LEYL+GGELFM LER+ ED FYL+E LALGHLH +G+IYRDLK EN++LD GHVKLTDFGL KE + +TH+FCGT+EYMAPEIL R GHG +VDWWS+G L++DML G PF NR + I+ + AKL +P +LT + L++ L+ + RLG G +D ++ H FF+ +NWD LAR L+PP P L S DDVS FD + + SP TT +S F+ F+YV+P +
Sbjct: 35 LDDVDLEPELCINLHQDT--EGQETIQLCEENVNPGKIKLGPKDFELKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQK-DTAHTRAERNILEAVKHPFIVELVYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGHLHKLGIIYRDLKPENILLDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMFDMLTGVPPFTAENRKKTIETILKAKLNLPAYLTPEARDLVRRLMKRQEPQRLGSGPEDAAAVQIHPFFKHVNWDDVLARRLEPPIKPLLRSEDDVSQFDTRFTRQIPVDSPDDTTLSESANLIFQGFTYVAPSI 404
BLAST of Ribosomal protein S6 kinase vs. Ensembl Fly
Match: S6kII (gene:FBgn0262866 transcript:FBtr0333715) HSP 1 Score: 287.73 bits (735), Expect = 6.848e-87 Identity = 150/325 (46.15%), Postives = 216/325 (66.46%), Query Frame = 1
Query: 292 YGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKERNDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISPTTTDDSNCY-WFENFSYVSPQVYLELSENGS 1263
+G+VFL +K+ G AG +AMKV+KKA L K D + ER IL V H F+V+L++AFQT L+L+L++L GG+LF +L ++ TE++ +FYLAE LA+ HLH++G+IYRDLK EN++LD +GH+ LTDFGLSK+ D T+SFCGTVEYMAPEI+ R+GH + DWWS G+L+Y+ML GN PF G R + + ++ +KL +P L+ + LL+ L +NP+ RLG G + + +IK H FF +I+W + ++++PPFIP + SRDD FD S+ SP ++ + F FS+V+P V LE GS
Sbjct: 210 FGKVFLVRKIIGKDAGTLYAMKVLKKATL---KVKDRVRSTNERKILADVGHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPLDGSKTYSFCGTVEYMAPEIVNRKGHDFAADWWSFGVLMYEMLTGNLPFHGQTRQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFATIDWVRLERKQVRPPFIPAV-SRDDAFYFDVEYTSKSPRDSPGGPISASAHEIFRGFSFVAP-VLLEGQCAGS 529 HSP 2 Score: 109.383 bits (272), Expect = 1.241e-24 Identity = 66/183 (36.07%), Postives = 103/183 (56.28%), Query Frame = 1
Query: 340 EYFAMKVVKKARLITNKKNDTKYAMTERNI-LEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENV----MLDRYGHVKLTDFGLSKE-RNDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFV 870
+++A+KV++KA + + + E I L NHP +V LY ++ S +LV+E L GGEL ++ + E EA L A+ +LH GV++RDLK N+ M +KL D G +K+ R D+ L + C T ++APE+L+R+G+ + D WS+G+LLY ML G +PF
Sbjct: 592 KHYAVKVIEKAAVAAASTSTSADCWEEVEIMLRYGNHPNIVTLYSVYEDAGSAYLVMELLKGGELLDRILAVGQMCESEASAVLRTIASAVAYLHEHGVVHRDLKPSNMIYASMRQTPETLKLCDLGFAKQLRADNGLLMTPCYTANFVAPEVLKRQGYDLACDIWSLGVLLYIMLSGRTPFA 774
BLAST of Ribosomal protein S6 kinase vs. Ensembl Fly
Match: S6kII (gene:FBgn0262866 transcript:FBtr0077360) HSP 1 Score: 287.73 bits (735), Expect = 6.848e-87 Identity = 150/325 (46.15%), Postives = 216/325 (66.46%), Query Frame = 1
Query: 292 YGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKERNDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISPTTTDDSNCY-WFENFSYVSPQVYLELSENGS 1263
+G+VFL +K+ G AG +AMKV+KKA L K D + ER IL V H F+V+L++AFQT L+L+L++L GG+LF +L ++ TE++ +FYLAE LA+ HLH++G+IYRDLK EN++LD +GH+ LTDFGLSK+ D T+SFCGTVEYMAPEI+ R+GH + DWWS G+L+Y+ML GN PF G R + + ++ +KL +P L+ + LL+ L +NP+ RLG G + + +IK H FF +I+W + ++++PPFIP + SRDD FD S+ SP ++ + F FS+V+P V LE GS
Sbjct: 210 FGKVFLVRKIIGKDAGTLYAMKVLKKATL---KVKDRVRSTNERKILADVGHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPLDGSKTYSFCGTVEYMAPEIVNRKGHDFAADWWSFGVLMYEMLTGNLPFHGQTRQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFATIDWVRLERKQVRPPFIPAV-SRDDAFYFDVEYTSKSPRDSPGGPISASAHEIFRGFSFVAP-VLLEGQCAGS 529 HSP 2 Score: 109.383 bits (272), Expect = 1.241e-24 Identity = 66/183 (36.07%), Postives = 103/183 (56.28%), Query Frame = 1
Query: 340 EYFAMKVVKKARLITNKKNDTKYAMTERNI-LEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENV----MLDRYGHVKLTDFGLSKE-RNDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFV 870
+++A+KV++KA + + + E I L NHP +V LY ++ S +LV+E L GGEL ++ + E EA L A+ +LH GV++RDLK N+ M +KL D G +K+ R D+ L + C T ++APE+L+R+G+ + D WS+G+LLY ML G +PF
Sbjct: 592 KHYAVKVIEKAAVAAASTSTSADCWEEVEIMLRYGNHPNIVTLYSVYEDAGSAYLVMELLKGGELLDRILAVGQMCESEASAVLRTIASAVAYLHEHGVVHRDLKPSNMIYASMRQTPETLKLCDLGFAKQLRADNGLLMTPCYTANFVAPEVLKRQGYDLACDIWSLGVLLYIMLSGRTPFA 774
BLAST of Ribosomal protein S6 kinase vs. Ensembl Fly
Match: Akt1 (gene:FBgn0010379 transcript:FBtr0083226) HSP 1 Score: 254.988 bits (650), Expect = 7.141e-78 Identity = 144/332 (43.37%), Postives = 210/332 (63.25%), Query Frame = 1
Query: 184 DSTSKSVDICEETVNPPGVK-VTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP 1173
D S+ + T N GVK VT +F+ LK LGKG +G+V L ++ A + +A+K++KK +I +K++ + +TE +L++ NHPFL+ L ++FQTN L V++Y+ GGELF L + TED RFY AE ALG+LHS G+IYRDLK EN++LD+ GH+K+ DFGL KE T +FCGT EY+APE+L +G +VDWW G+++Y+M+ G PF + + + ++K PR +TD K+LL LL K+PK RLGGG+ DV+EI+ H FF SINW + +++ PPF P+++S D FDK E ++P
Sbjct: 159 DELSEQFSVQGTTCNSSGVKKVTLENFEFLKVLGKGTFGKVILCREKATA---KLYAIKILKKEVII--QKDEVAHTLTESRVLKSTNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELTP 485
BLAST of Ribosomal protein S6 kinase vs. Ensembl Zebrafish
Match: rps6kb1b (ribosomal protein S6 kinase b, polypeptide 1b [Source:ZFIN;Acc:ZDB-GENE-040426-2038]) HSP 1 Score: 354.369 bits (908), Expect = 1.953e-116 Identity = 190/360 (52.78%), Postives = 245/360 (68.06%), Query Frame = 1
Query: 196 KSVDICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP--TTTDDSNCYWFENFSYVSPQVYLELSENGSF 1266
+ ++I E+ VN + F+LL+ LGKGGYG+VF +KV+GA G+ FAMKV+KKA ++ N K DT + ERNILE V HPF+V L +AFQT L+L+LEYL+GGELFMQLER+ ED A FYLAE ++ALGHLH G+IYRDLK EN+ML+ GHVKLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +VDWWS+G L+YDML G PF G NR + I K+ KL +P +LT + LLK LL ++ +RLG G D E++ H FFR +NWD LAR+++PPF P L S +DVS FD S+ + SP +T +S F F+YV+P V + E SF
Sbjct: 44 EKIEISEDNVNQGTENIRPECFELLRVLGKGGYGKVFQVRKVSGAATGKIFAMKVLKKAMIVRNAK-DTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNNQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKRLLKRSASSRLGAGPGDATEVQTHPFFRHVNWDDLLARKVEPPFKPFLQSAEDVSQFDSKFTSQTPVDSPDDSTLSESANQVFLGFTYVAPSVLENIKEKFSF 402
BLAST of Ribosomal protein S6 kinase vs. Ensembl Zebrafish
Match: rps6kb1a (ribosomal protein S6 kinase b, polypeptide 1a [Source:ZFIN;Acc:ZDB-GENE-091113-52]) HSP 1 Score: 350.132 bits (897), Expect = 1.215e-114 Identity = 192/372 (51.61%), Postives = 248/372 (66.67%), Query Frame = 1
Query: 160 DNLNKDEYDSTSKSVDICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP--TTTDDSNCYWFENFSYVSPQVYLELSENGSF 1266
D + E+ + +I E++VN K+ F+LL+ LGKGGYG+VF +KV GA +G+ FAMKV+KKA ++ N K DT + ER+ILE V HPF+V L +AFQT L+L+LEYL+GGELFMQLER+ ED A FYLAE +LALGHLH G+IYRDLK EN+ML+ GHVKLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +VDWWS+G L+YDML G PF NR + I K+ KL +P +LT + LLK LL +N R+G +DV +I+RH FFR INWD LA ++ PPF P L S DDVS FD S+ + SP T +S+ F F+Y++P V + E +F
Sbjct: 32 DQCSGFEFMEDCEKFEISEDSVNQGTEKIRPECFELLRVLGKGGYGKVFQVRKVAGAASGKIFAMKVLKKAMIVRNAK-DTAHTKAERSILEEVKHPFIVDLIYAFQTGEKLYLILEYLSGGELFMQLEREGIFLEDTACFYLAEISLALGHLHQKGIIYRDLKPENIMLNYNGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILTRSGHNRAVDWWSLGALMYDMLTGAPPFTAENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNASVRIGASPRDVLDIQRHSFFRHINWDDLLAFKIDPPFKPFLQSADDVSQFDSKFTSQTPVDSPDDTKLSESDNQVFLGFTYIAPSVLENIKEKFTF 402
BLAST of Ribosomal protein S6 kinase vs. Ensembl Zebrafish
Match: BX000486.1 (ribosomal protein S6 kinase b, polypeptide 1a [Source:NCBI gene;Acc:562242]) HSP 1 Score: 348.977 bits (894), Expect = 2.809e-114 Identity = 190/357 (53.22%), Postives = 243/357 (68.07%), Query Frame = 1
Query: 205 DICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP--TTTDDSNCYWFENFSYVSPQVYLELSENGSF 1266
+I E++VN K+ F+LL+ LGKGGYG+VF +KV GA +G+ FAMKV+KKA ++ N K DT + ER+ILE V HPF+V L +AFQT L+L+LEYL+GGELFMQLER+ ED A FYLAE +LALGHLH G+IYRDLK EN+ML+ GHVKLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +VDWWS+G L+YDML G PF NR + I K+ KL +P +LT + LLK LL +N R+G +DV +I+RH FFR INWD LA ++ PPF P L S DDVS FD S+ + SP T +S+ F F+Y++P V + E +F
Sbjct: 48 EISEDSVNQGTEKIRPECFELLRVLGKGGYGKVFQVRKVAGAASGKIFAMKVLKKAMIVRNAK-DTAHTKAERSILEEVKHPFIVDLIYAFQTGEKLYLILEYLSGGELFMQLEREGIFLEDTACFYLAEISLALGHLHQKGIIYRDLKPENIMLNYNGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILTRSGHNRAVDWWSLGALMYDMLTGAPPFTAENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNASVRIGASPRDVLDIQRHSFFRHINWDDLLAFKIDPPFKPFLQSADDVSQFDSKFTSQTPVDSPDDTKLSESDNQVFLGFTYIAPSVLENIKEKFTF 403
BLAST of Ribosomal protein S6 kinase vs. Ensembl Zebrafish
Match: rps6kb1b (ribosomal protein S6 kinase b, polypeptide 1b [Source:ZFIN;Acc:ZDB-GENE-040426-2038]) HSP 1 Score: 315.849 bits (808), Expect = 3.770e-101 Identity = 181/382 (47.38%), Postives = 240/382 (62.83%), Query Frame = 1
Query: 196 KSVDICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGEL-FMQLER----QHTLTED-----------------EARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP--TTTDDSNCYWFENFSYVSPQVYLELSENGSF 1266
+ ++I E+ VN + F+LL+ LGKGGYG+VF +KV+GA G+ FAMKV+KKA ++ N K DT + ERNILE V HPF+V L +AFQT L+L+LEYL+G L F++++ H+ FYLAE ++ALGHLH G+IYRDLK EN+ML+ GHVKLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +VDWWS+G L+YDML G PF G NR + I K+ KL +P +LT + LLK LL ++ +RLG G D E++ H FFR +NWD LAR+++PPF P L S +DVS FD S+ + SP +T +S F F+YV+P V + E SF
Sbjct: 44 EKIEISEDNVNQGTENIRPECFELLRVLGKGGYGKVFQVRKVSGAATGKIFAMKVLKKAMIVRNAK-DTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGLNLCFLEIDNFSFFPHSFCCCGVAKGLIQPLKCCSGLLTCSFYLAEISMALGHLHQKGIIYRDLKPENIMLNNQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKRLLKRSASSRLGAGPGDATEVQTHPFFRHVNWDDLLARKVEPPFKPFLQSAEDVSQFDSKFTSQTPVDSPDDSTLSESANQVFLGFTYVAPSVLENIKEKFSF 424
BLAST of Ribosomal protein S6 kinase vs. Ensembl Zebrafish
Match: rps6ka2 (ribosomal protein S6 kinase, polypeptide 2 [Source:ZFIN;Acc:ZDB-GENE-090827-1]) HSP 1 Score: 311.227 bits (796), Expect = 5.318e-97 Identity = 172/356 (48.31%), Postives = 233/356 (65.45%), Query Frame = 1
Query: 166 LNKDEYDSTSKSVDICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKERND-DELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISPTTTDDSNCY-WFENFSYVS 1227
L K E DS K DI V K F+LLK LG+G YG+VFL +K+ G+ G+ +AMKV+KKA L K D + ER+IL VNHPF+VKL++AFQT L+L+L++L GG+LF +L ++ TE++ +FYLAE LAL HLHS+G+IYRDLK EN++LD GH+K+TDFGLSKE D D+ +SFCGT+EYMAPE++ RRGH S DWWS G+L+++ML G+ PF G +R + + + AKL +P+FL+ + LL+ L +NP RLG G VEEIKRH FF +I+W+K RE+KPPF P + +D FD S SP +N + F FS+V+
Sbjct: 29 LCKLEDDSILKEFDISHH-VKEGFEKADPSQFELLKVLGQGSYGKVFLVRKIKGSDTGQLYAMKVLKKATL---KVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSPEVQSLLRALFKRNPSNRLGAGPDGVEEIKRHIFFATIDWNKLYRREIKPPFKPAVGRPEDTFHFDPEFTSRTPTDSPGVPASANAHQLFRGFSFVA 380 HSP 2 Score: 110.153 bits (274), Expect = 7.500e-25 Identity = 58/174 (33.33%), Postives = 101/174 (58.05%), Query Frame = 1
Query: 427 ILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVM-LDRYG---HVKLTDFGLSKE-RNDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGG---NRSQVIQKVTNAKLKI 924
+L HP ++ L + ++LV+E + GGEL ++ RQ +E EA L T + +LHS GV++RDLK N++ +D G +++ DFG +K+ R ++ L + C T ++APE+L+++G+ + D WS+GILLY ML G +PF G +++ ++ + K +
Sbjct: 460 LLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQKCFSEREASAVLCTITKTVEYLHSQGVVHRDLKPSNILYVDETGDPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKKQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKFAL 633
BLAST of Ribosomal protein S6 kinase vs. Ensembl Xenopus
Match: l3hypdh (L-3-hydroxyproline dehydratase (trans-) [Source:Xenbase;Acc:XB-GENE-1000732]) HSP 1 Score: 352.058 bits (902), Expect = 2.662e-115 Identity = 201/396 (50.76%), Postives = 258/396 (65.15%), Query Frame = 1
Query: 103 DLKLKCDLINGIELEANDSDNLNKDEYDSTS-----KSVDICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP--TTTDDSNCYWFENFSYVSPQVYLELSENGSF 1266
DL D I+ ELE ++L D S+S + +I E +VN K+ F+LL+ LGKGGYG+VF +KV GA G+ FAMKV+KKA ++ N K DT + ERNILE V HPF+V L +AFQT L+L+LEYL+GGELFMQLER+ ED A FYLAE ++ALGHLH G+IYRDLK EN+ML+ GHVKLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +VDWWS+G L+YDML G PF G NR + I K+ KL +P +LT + LLK LL +N +RLG G D +++ H FFR INW++ LAR+++PPF P L S +DVS FD + + SP T +S F F+YV+P V + E SF
Sbjct: 8 DLDQPEDAISDDELEDGVREDLLDDLLVSSSGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVIGAHTGKIFAMKVLKKAMIVRNAK-DTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGAGDAIDVQGHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDATLSESANQVFVGFTYVAPSVLESVKEKFSF 402
BLAST of Ribosomal protein S6 kinase vs. Ensembl Xenopus
Match: l3hypdh (L-3-hydroxyproline dehydratase (trans-) [Source:Xenbase;Acc:XB-GENE-1000732]) HSP 1 Score: 348.591 bits (893), Expect = 2.212e-114 Identity = 190/357 (53.22%), Postives = 242/357 (67.79%), Query Frame = 1
Query: 205 DICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP--TTTDDSNCYWFENFSYVSPQVYLELSENGSF 1266
+I E +VN K+ F+LL+ LGKGGYG+VF +KV GA G+ FAMKV+KKA ++ N K DT + ERNILE V HPF+V L +AFQT L+L+LEYL+GGELFMQLER+ ED A FYLAE ++ALGHLH G+IYRDLK EN+ML+ GHVKLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +VDWWS+G L+YDML G PF G NR + I K+ KL +P +LT + LLK LL +N +RLG G D +++ H FFR INW++ LAR+++PPF P L S +DVS FD + + SP T +S F F+YV+P V + E SF
Sbjct: 18 EISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVIGAHTGKIFAMKVLKKAMIVRNAK-DTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGAGDAIDVQGHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDATLSESANQVFVGFTYVAPSVLESVKEKFSF 373
BLAST of Ribosomal protein S6 kinase vs. Ensembl Xenopus
Match: l3hypdh (L-3-hydroxyproline dehydratase (trans-) [Source:Xenbase;Acc:XB-GENE-1000732]) HSP 1 Score: 348.206 bits (892), Expect = 3.629e-114 Identity = 190/357 (53.22%), Postives = 242/357 (67.79%), Query Frame = 1
Query: 205 DICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP--TTTDDSNCYWFENFSYVSPQVYLELSENGSF 1266
+I E +VN K+ F+LL+ LGKGGYG+VF +KV GA G+ FAMKV+KKA ++ N K DT + ERNILE V HPF+V L +AFQT L+L+LEYL+GGELFMQLER+ ED A FYLAE ++ALGHLH G+IYRDLK EN+ML+ GHVKLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +VDWWS+G L+YDML G PF G NR + I K+ KL +P +LT + LLK LL +N +RLG G D +++ H FFR INW++ LAR+++PPF P L S +DVS FD + + SP T +S F F+YV+P V + E SF
Sbjct: 26 EISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVIGAHTGKIFAMKVLKKAMIVRNAK-DTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGAGDAIDVQGHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDATLSESANQVFVGFTYVAPSVLESVKEKFSF 381
BLAST of Ribosomal protein S6 kinase vs. Ensembl Xenopus
Match: l3hypdh (L-3-hydroxyproline dehydratase (trans-) [Source:Xenbase;Acc:XB-GENE-1000732]) HSP 1 Score: 348.206 bits (892), Expect = 6.413e-114 Identity = 190/357 (53.22%), Postives = 242/357 (67.79%), Query Frame = 1
Query: 205 DICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP--TTTDDSNCYWFENFSYVSPQVYLELSENGSF 1266
+I E +VN K+ F+LL+ LGKGGYG+VF +KV GA G+ FAMKV+KKA ++ N K DT + ERNILE V HPF+V L +AFQT L+L+LEYL+GGELFMQLER+ ED A FYLAE ++ALGHLH G+IYRDLK EN+ML+ GHVKLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +VDWWS+G L+YDML G PF G NR + I K+ KL +P +LT + LLK LL +N +RLG G D +++ H FFR INW++ LAR+++PPF P L S +DVS FD + + SP T +S F F+YV+P V + E SF
Sbjct: 40 EISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVIGAHTGKIFAMKVLKKAMIVRNAK-DTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGAGDAIDVQGHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDATLSESANQVFVGFTYVAPSVLESVKEKFSF 395
BLAST of Ribosomal protein S6 kinase vs. Ensembl Xenopus
Match: l3hypdh (L-3-hydroxyproline dehydratase (trans-) [Source:Xenbase;Acc:XB-GENE-1000732]) HSP 1 Score: 348.591 bits (893), Expect = 1.097e-113 Identity = 190/357 (53.22%), Postives = 242/357 (67.79%), Query Frame = 1
Query: 205 DICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP--TTTDDSNCYWFENFSYVSPQVYLELSENGSF 1266
+I E +VN K+ F+LL+ LGKGGYG+VF +KV GA G+ FAMKV+KKA ++ N K DT + ERNILE V HPF+V L +AFQT L+L+LEYL+GGELFMQLER+ ED A FYLAE ++ALGHLH G+IYRDLK EN+ML+ GHVKLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +VDWWS+G L+YDML G PF G NR + I K+ KL +P +LT + LLK LL +N +RLG G D +++ H FFR INW++ LAR+++PPF P L S +DVS FD + + SP T +S F F+YV+P V + E SF
Sbjct: 71 EISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVIGAHTGKIFAMKVLKKAMIVRNAK-DTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGAGDAIDVQGHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDATLSESANQVFVGFTYVAPSVLESVKEKFSF 426
BLAST of Ribosomal protein S6 kinase vs. Ensembl Mouse
Match: Rps6kb1 (ribosomal protein S6 kinase, polypeptide 1 [Source:MGI Symbol;Acc:MGI:1270849]) HSP 1 Score: 350.903 bits (899), Expect = 9.806e-115 Identity = 191/357 (53.50%), Postives = 243/357 (68.07%), Query Frame = 1
Query: 205 DICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP--TTTDDSNCYWFENFSYVSPQVYLELSENGSF 1266
+I E +VN K+ F+LL+ LGKGGYG+VF +KV GA G+ FAMKV+KKA ++ N K DT + ERNILE V HPF+V L +AFQT L+L+LEYL+GGELFMQLER+ ED A FYLAE ++ALGHLH G+IYRDLK EN+ML+ GHVKLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +VDWWS+G L+YDML G PF G NR + I K+ KL +P +LT + LLK LL +N +RLG G D E++ H FFR INW++ LAR+++PPF P L S +DVS FD + + SP +T +S F F+YV+P V + E SF
Sbjct: 73 EISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAK-DTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSF 428
BLAST of Ribosomal protein S6 kinase vs. Ensembl Mouse
Match: Rps6kb2 (ribosomal protein S6 kinase, polypeptide 2 [Source:MGI Symbol;Acc:MGI:1927343]) HSP 1 Score: 341.273 bits (874), Expect = 1.765e-111 Identity = 183/358 (51.12%), Postives = 239/358 (66.76%), Query Frame = 1
Query: 202 VDICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP--TTTDDSNCYWFENFSYVSPQVYLELSENGSF 1266
V++ E +VN ++ H F+LL LGKGGYG+VF +KV G G+ +AMKV++KA+++ + K DT + ERNILE+V HPF+V+L +AFQT L+L+LE L+GGELF LER+ ED A FYLAE TLALGHLHS G+IYRDLK EN+ML GH+KLTDFGL KE ++ +TH+FCGT+EYMAPEIL R GH +VDWWS+G L+YDML G+ PF NR + + K+ KL +P +LT + L K L +NP R+GGG D +++RH FFR INWD LAR + PPF P L S +DVS FD + + SP T +S F F+YV+P V + E SF
Sbjct: 48 VELTESSVNLGPERIGPHCFELLSVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVCSAK-DTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSHGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAITHTFCGTIEYMAPEILVRTGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIKGKLVLPPYLTPDARDLAKKFLKRNPTQRIGGGLGDAADVQRHPFFRHINWDDLLARRVDPPFRPSLQSEEDVSQFDARFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSIKEGFSF 404
BLAST of Ribosomal protein S6 kinase vs. Ensembl Mouse
Match: Rps6kb2 (ribosomal protein S6 kinase, polypeptide 2 [Source:MGI Symbol;Acc:MGI:1927343]) HSP 1 Score: 341.273 bits (874), Expect = 1.765e-111 Identity = 183/358 (51.12%), Postives = 239/358 (66.76%), Query Frame = 1
Query: 202 VDICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP--TTTDDSNCYWFENFSYVSPQVYLELSENGSF 1266
V++ E +VN ++ H F+LL LGKGGYG+VF +KV G G+ +AMKV++KA+++ + K DT + ERNILE+V HPF+V+L +AFQT L+L+LE L+GGELF LER+ ED A FYLAE TLALGHLHS G+IYRDLK EN+ML GH+KLTDFGL KE ++ +TH+FCGT+EYMAPEIL R GH +VDWWS+G L+YDML G+ PF NR + + K+ KL +P +LT + L K L +NP R+GGG D +++RH FFR INWD LAR + PPF P L S +DVS FD + + SP T +S F F+YV+P V + E SF
Sbjct: 48 VELTESSVNLGPERIGPHCFELLSVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVCSAK-DTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSHGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAITHTFCGTIEYMAPEILVRTGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIKGKLVLPPYLTPDARDLAKKFLKRNPTQRIGGGLGDAADVQRHPFFRHINWDDLLARRVDPPFRPSLQSEEDVSQFDARFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSIKEGFSF 404
BLAST of Ribosomal protein S6 kinase vs. Ensembl Mouse
Match: Rps6kb2 (ribosomal protein S6 kinase, polypeptide 2 [Source:MGI Symbol;Acc:MGI:1927343]) HSP 1 Score: 334.339 bits (856), Expect = 5.625e-110 Identity = 178/348 (51.15%), Postives = 235/348 (67.53%), Query Frame = 1
Query: 196 KSVDICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISPTTTDDSNCYWFENFSYVSPQV 1236
+ V++ E +VN ++ H F+LL LGKGGYG+VF +KV G G+ +AMKV++KA+++ + K DT + ERNILE+V HPF+V+L +AFQT L+L+LE L+GGELF LER+ ED A FYLAE TLALGHLHS G+IYRDLK EN+ML GH+KLTDFGL KE ++ +TH+FCGT+EYMAPEIL R GH +VDWWS+G L+YDML G+ PF NR + + K+ KL +P +LT + L K L +NP R+GGG D +++RH FFR INWD LAR + PPF P L S +DVS FD + + SP DD+ N +++ PQV
Sbjct: 46 EEVELTESSVNLGPERIGPHCFELLSVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVCSAK-DTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSHGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAITHTFCGTIEYMAPEILVRTGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIKGKLVLPPYLTPDARDLAKKFLKRNPTQRIGGGLGDAADVQRHPFFRHINWDDLLARRVDPPFRPSLQSEEDVSQFDARFTRQTPVDSP---DDTALSESANQAFLPPQV 389
BLAST of Ribosomal protein S6 kinase vs. Ensembl Mouse
Match: Rps6kb2 (ribosomal protein S6 kinase, polypeptide 2 [Source:MGI Symbol;Acc:MGI:1927343]) HSP 1 Score: 334.339 bits (856), Expect = 5.625e-110 Identity = 178/348 (51.15%), Postives = 235/348 (67.53%), Query Frame = 1
Query: 196 KSVDICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISPTTTDDSNCYWFENFSYVSPQV 1236
+ V++ E +VN ++ H F+LL LGKGGYG+VF +KV G G+ +AMKV++KA+++ + K DT + ERNILE+V HPF+V+L +AFQT L+L+LE L+GGELF LER+ ED A FYLAE TLALGHLHS G+IYRDLK EN+ML GH+KLTDFGL KE ++ +TH+FCGT+EYMAPEIL R GH +VDWWS+G L+YDML G+ PF NR + + K+ KL +P +LT + L K L +NP R+GGG D +++RH FFR INWD LAR + PPF P L S +DVS FD + + SP DD+ N +++ PQV
Sbjct: 46 EEVELTESSVNLGPERIGPHCFELLSVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVCSAK-DTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSHGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAITHTFCGTIEYMAPEILVRTGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIKGKLVLPPYLTPDARDLAKKFLKRNPTQRIGGGLGDAADVQRHPFFRHINWDDLLARRVDPPFRPSLQSEEDVSQFDARFTRQTPVDSP---DDTALSESANQAFLPPQV 389
BLAST of Ribosomal protein S6 kinase vs. UniProt/SwissProt
Match: sp|Q8BSK8|KS6B1_MOUSE (Ribosomal protein S6 kinase beta-1 OS=Mus musculus OX=10090 GN=Rps6kb1 PE=1 SV=2) HSP 1 Score: 350.903 bits (899), Expect = 6.859e-114 Identity = 191/357 (53.50%), Postives = 243/357 (68.07%), Query Frame = 1
Query: 205 DICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP--TTTDDSNCYWFENFSYVSPQVYLELSENGSF 1266
+I E +VN K+ F+LL+ LGKGGYG+VF +KV GA G+ FAMKV+KKA ++ N K DT + ERNILE V HPF+V L +AFQT L+L+LEYL+GGELFMQLER+ ED A FYLAE ++ALGHLH G+IYRDLK EN+ML+ GHVKLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +VDWWS+G L+YDML G PF G NR + I K+ KL +P +LT + LLK LL +N +RLG G D E++ H FFR INW++ LAR+++PPF P L S +DVS FD + + SP +T +S F F+YV+P V + E SF
Sbjct: 73 EISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAK-DTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSF 428
BLAST of Ribosomal protein S6 kinase vs. UniProt/SwissProt
Match: sp|P23443|KS6B1_HUMAN (Ribosomal protein S6 kinase beta-1 OS=Homo sapiens OX=9606 GN=RPS6KB1 PE=1 SV=2) HSP 1 Score: 350.903 bits (899), Expect = 6.933e-114 Identity = 191/357 (53.50%), Postives = 243/357 (68.07%), Query Frame = 1
Query: 205 DICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP--TTTDDSNCYWFENFSYVSPQVYLELSENGSF 1266
+I E +VN K+ F+LL+ LGKGGYG+VF +KV GA G+ FAMKV+KKA ++ N K DT + ERNILE V HPF+V L +AFQT L+L+LEYL+GGELFMQLER+ ED A FYLAE ++ALGHLH G+IYRDLK EN+ML+ GHVKLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +VDWWS+G L+YDML G PF G NR + I K+ KL +P +LT + LLK LL +N +RLG G D E++ H FFR INW++ LAR+++PPF P L S +DVS FD + + SP +T +S F F+YV+P V + E SF
Sbjct: 73 EISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAK-DTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSF 428
BLAST of Ribosomal protein S6 kinase vs. UniProt/SwissProt
Match: sp|P67999|KS6B1_RAT (Ribosomal protein S6 kinase beta-1 OS=Rattus norvegicus OX=10116 GN=Rps6kb1 PE=1 SV=1) HSP 1 Score: 350.903 bits (899), Expect = 7.161e-114 Identity = 191/357 (53.50%), Postives = 243/357 (68.07%), Query Frame = 1
Query: 205 DICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP--TTTDDSNCYWFENFSYVSPQVYLELSENGSF 1266
+I E +VN K+ F+LL+ LGKGGYG+VF +KV GA G+ FAMKV+KKA ++ N K DT + ERNILE V HPF+V L +AFQT L+L+LEYL+GGELFMQLER+ ED A FYLAE ++ALGHLH G+IYRDLK EN+ML+ GHVKLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +VDWWS+G L+YDML G PF G NR + I K+ KL +P +LT + LLK LL +N +RLG G D E++ H FFR INW++ LAR+++PPF P L S +DVS FD + + SP +T +S F F+YV+P V + E SF
Sbjct: 73 EISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAK-DTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSF 428
BLAST of Ribosomal protein S6 kinase vs. UniProt/SwissProt
Match: sp|P67998|KS6B1_RABIT (Ribosomal protein S6 kinase beta-1 OS=Oryctolagus cuniculus OX=9986 GN=RPS6KB1 PE=2 SV=1) HSP 1 Score: 350.903 bits (899), Expect = 7.639e-114 Identity = 191/357 (53.50%), Postives = 243/357 (68.07%), Query Frame = 1
Query: 205 DICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP--TTTDDSNCYWFENFSYVSPQVYLELSENGSF 1266
+I E +VN K+ F+LL+ LGKGGYG+VF +KV GA G+ FAMKV+KKA ++ N K DT + ERNILE V HPF+V L +AFQT L+L+LEYL+GGELFMQLER+ ED A FYLAE ++ALGHLH G+IYRDLK EN+ML+ GHVKLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +VDWWS+G L+YDML G PF G NR + I K+ KL +P +LT + LLK LL +N +RLG G D E++ H FFR INW++ LAR+++PPF P L S +DVS FD + + SP +T +S F F+YV+P V + E SF
Sbjct: 73 EISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAK-DTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSF 428
BLAST of Ribosomal protein S6 kinase vs. UniProt/SwissProt
Match: sp|Q6TJY3|KS6B1_BOVIN (Ribosomal protein S6 kinase beta-1 OS=Bos taurus OX=9913 GN=RPS6KB1 PE=2 SV=1) HSP 1 Score: 348.977 bits (894), Expect = 3.862e-113 Identity = 190/357 (53.22%), Postives = 242/357 (67.79%), Query Frame = 1
Query: 205 DICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP--TTTDDSNCYWFENFSYVSPQVYLELSENGSF 1266
+I E +VN K+ F+LL+ LGKGGYG+VF +KV GA G+ FAMKV+KKA ++ N K DT + ERNILE V HPF+V L +AFQT L+L+LEYL+GGELFMQLER+ ED A FYLAE ++ALGHLH G+IYRDLK EN+ML+ GHVKLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +VDWWS+G L+YDML G PF G NR + I K+ KL +P +LT + LLK LL +N +RLG G D E++ H FFR INW++ LAR+++PPF P L S +DVS FD + + SP + +S F F+YV+P V + E SF
Sbjct: 73 EISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAK-DTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSALSESANQVFLGFTYVAPSVLESVKEKFSF 428
BLAST of Ribosomal protein S6 kinase vs. TrEMBL
Match: A0A068YKN8 (Non-specific serine/threonine protein kinase OS=Echinococcus multilocularis OX=6211 GN=EmuJ_001044600 PE=4 SV=1) HSP 1 Score: 390.193 bits (1001), Expect = 1.570e-126 Identity = 205/364 (56.32%), Postives = 260/364 (71.43%), Query Frame = 1
Query: 166 LNKDEYDSTSKSVDICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKERNDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP---TTTDDSNCYWFENFSYVSPQVYLEL 1248
L+ +E + + V+ICE+TVNP KV DF LLK LGKGGYG+VFLA+K+ G +G+ FAMKV+KKA ++TN K DT + TERNILE + HPFLV+L++AFQT L+LVLE+LAGGELF QLE++ ED+A FYL+E LA+GHLH +G++YRDLK EN++LD GHVKLTDFGLSKER D +LTH+FCGT+EYMAPEIL R+GHG SVDWWS+G L+YDML G PF G +R + ++ V + + +LT K LLK LL K RLG G D EEIK+H FF+SINWD+ AR+L+PPF P L+S DVS FD SE + SP SNC F+ F+YV PQV + +
Sbjct: 44 LSVEEMNEHVERVEICEDTVNPGQPKVRPQDFTLLKVLGKGGYGKVFLARKITGVDSGQIFAMKVLKKASIVTNAK-DTAHTKTERNILEMIKHPFLVQLHYAFQTPGKLYLVLEFLAGGELFTQLEKEGVFMEDQASFYLSEIILAIGHLHKMGIVYRDLKPENILLDTEGHVKLTDFGLSKERVDQDLTHTFCGTIEYMAPEILLRQGHGKSVDWWSLGTLMYDMLSGGPPFTGDDRKKTMEAVLRGRYTLAPYLTYEAKDLLKRLLKKTVSERLGSGPTDAEEIKQHPFFQSINWDQVYARQLEPPFKPSLTSETDVSRFDPLFTSENPVESPDDGVPISASNCNVFDGFTYVDPQVQISM 406
BLAST of Ribosomal protein S6 kinase vs. TrEMBL
Match: A0A068WC56 (Non-specific serine/threonine protein kinase OS=Echinococcus granulosus OX=6210 GN=EgrG_001044600 PE=4 SV=1) HSP 1 Score: 389.808 bits (1000), Expect = 2.316e-126 Identity = 205/364 (56.32%), Postives = 260/364 (71.43%), Query Frame = 1
Query: 166 LNKDEYDSTSKSVDICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKERNDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP---TTTDDSNCYWFENFSYVSPQVYLEL 1248
L+ +E + + V+ICE+TVNP KV DF LLK LGKGGYG+VFLA+K+ G +G+ FAMKV+KKA ++TN K DT + TERNILE + HPFLV+L++AFQT L+LVLE+LAGGELF QLE++ ED+A FYL+E LA+GHLH +G++YRDLK EN++LD GHVKLTDFGLSKER D +LTH+FCGT+EYMAPEIL R+GHG SVDWWS+G L+YDML G PF G +R + ++ V + + +LT K LLK LL K RLG G D EEIK+H FF+SINWD+ AR+L+PPF P L+S DVS FD SE + SP SNC F+ F+YV PQV + +
Sbjct: 44 LSVEEMNEHVERVEICEDTVNPGQPKVRPQDFTLLKVLGKGGYGKVFLARKITGVDSGQIFAMKVLKKASIVTNAK-DTAHTKTERNILEMIKHPFLVQLHYAFQTPGKLYLVLEFLAGGELFTQLEKEGVFMEDQASFYLSEIILAIGHLHKMGIVYRDLKPENILLDTEGHVKLTDFGLSKERVDQDLTHTFCGTIEYMAPEILLRQGHGKSVDWWSLGTLMYDMLSGGPPFTGDDRKKTMEAVLRGRYTLAPYLTYEAKDLLKRLLKKTVSERLGSGPTDAEEIKQHPFFQSINWDQVYARQLEPPFKPSLTSETDVSRFDPLFTSENPVESPDDGVPISASNCDVFDGFTYVDPQVQISM 406
BLAST of Ribosomal protein S6 kinase vs. TrEMBL
Match: A0A0R3TRD3 (Non-specific serine/threonine protein kinase OS=Rodentolepis nana OX=102285 GN=HNAJ_LOCUS10136 PE=4 SV=1) HSP 1 Score: 389.037 bits (998), Expect = 4.661e-126 Identity = 205/364 (56.32%), Postives = 263/364 (72.25%), Query Frame = 1
Query: 166 LNKDEYDSTSKSVDICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKERNDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP---TTTDDSNCYWFENFSYVSPQVYLEL 1248
L+ +E + V+ICE+TVNP KV DF+LLK LGKGGYG+VFLA+K+ G G+ FAMKV+KKA ++TN K DT + TERNILE + HPFLV+L++AFQT L+LVLE+LAGGELF QLE++ E++A FYL+E LA+GHLHS+G++YRDLK EN++LD GHVKLTDFGLSKER D +LTH+FCGT+EYMAPEIL R+GHG SVDWWS+G L+YDML G PFVG +R + ++KV + +I +L+ K LL+ LL KN RLG G D EEIK+H FF SI+WD+ AR+L+PPF P L+S DVS FD SE + SP SN F+ F+YV PQV++ +
Sbjct: 44 LSVEEMSEYIERVEICEDTVNPGQPKVRPQDFNLLKVLGKGGYGKVFLAQKITGVDCGQIFAMKVLKKASIVTNAK-DTAHTKTERNILELIKHPFLVQLHYAFQTPGKLYLVLEFLAGGELFTQLEKEGVFLEEQAIFYLSEIILAIGHLHSMGIVYRDLKPENILLDTEGHVKLTDFGLSKERVDHDLTHTFCGTIEYMAPEILLRQGHGKSVDWWSLGTLMYDMLSGGPPFVGEDRKKTMEKVIRGRFQIAPYLSAEAKDLLRKLLKKNVSERLGSGPTDAEEIKKHLFFASISWDQVYARQLEPPFKPSLTSETDVSRFDPLFTSENPVESPDDGVPISASNLDVFDGFTYVDPQVHISM 406
BLAST of Ribosomal protein S6 kinase vs. TrEMBL
Match: A0A564YF52 (Non-specific serine/threonine protein kinase OS=Hymenolepis diminuta OX=6216 GN=WMSIL1_LOCUS5369 PE=4 SV=1) HSP 1 Score: 388.267 bits (996), Expect = 1.106e-125 Identity = 205/364 (56.32%), Postives = 262/364 (71.98%), Query Frame = 1
Query: 166 LNKDEYDSTSKSVDICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKERNDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP---TTTDDSNCYWFENFSYVSPQVYLEL 1248
L+ +E + V+ICE+TVNP KV DF+LLK LGKGGYG+VFLA+K+ G +G+ FAMKV+KKA ++TN K DT + TERNILE + HPFLV+L++AFQT L+LVLE+LAGGELF QLE++ ED+A FYL+E LA+GHLHS+G++YRDLK EN++LD GHVKLTDFGLSKER D +LTH+FCGT+EYMAPEIL R+GHG SVDWWS+G L+YDML G PFVG +R + ++KV + ++ +L+ K LL+ LL KN RLG G D EEIK+H FF INWD+ AR L+PPF P L+S DVS FD SE + SP SN F+ F+YV PQV++ +
Sbjct: 44 LSVEEMSEHIERVEICEDTVNPGQPKVRPQDFNLLKVLGKGGYGKVFLAQKITGVDSGQIFAMKVLKKASIVTNAK-DTAHTKTERNILEMIKHPFLVQLHYAFQTPGKLYLVLEFLAGGELFTQLEKEGVFLEDQAIFYLSEIILAIGHLHSMGIVYRDLKPENILLDTGGHVKLTDFGLSKERVDHDLTHTFCGTIEYMAPEILLRQGHGKSVDWWSLGTLMYDMLSGGPPFVGEDRKKTMEKVIRGRFQLAPYLSAEAKDLLRKLLKKNVGERLGSGPTDAEEIKQHPFFAPINWDQVYARRLEPPFKPSLTSETDVSRFDPLFTSENPVESPDDGVPISASNLDVFDGFTYVDPQVHISM 406
BLAST of Ribosomal protein S6 kinase vs. TrEMBL
Match: A0A0V0J6H0 (Non-specific serine/threonine protein kinase OS=Schistocephalus solidus OX=70667 GN=TR96085 PE=4 SV=1) HSP 1 Score: 385.956 bits (990), Expect = 1.567e-123 Identity = 207/381 (54.33%), Postives = 268/381 (70.34%), Query Frame = 1
Query: 166 LNKDEYDSTSKSVDICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKERNDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP---TTTDDSNCYWFENFSYVSPQVYLELSEN-----GSFSRQRTR 1284
L+ +E + V+ICE+TVNP KV DF LLK LGKGGYG+VFLA+K++G +G+ FAMKV+KKA ++T+ K DT + TERNILE + HPFLV+L++AFQT L+L LE+LAGGELF QLER+ ED+A FYLAE LA+GHLHS+G++YRDLK EN++LD GHVKLTDFGLSKER D +LTH+FCGT+EYMAPEIL R+GHG SVDWWS+G L+YDML G PF G +R + ++ V K + +L+ K LLK LL KN RLG E+D EEIK H FFR+ NWD+ AR+++PPF P L+S DVS FD +E + SP S C FE F+YV PQV++ ++ + ++ R+R R
Sbjct: 44 LSIEEMHDEVERVEICEDTVNPGQPKVRPQDFTLLKVLGKGGYGKVFLARKISGVDSGQVFAMKVLKKASIVTSAK-DTAHTKTERNILEMIKHPFLVQLHYAFQTPGKLYLALEFLAGGELFTQLEREGVFMEDQASFYLAEIILAIGHLHSMGIVYRDLKPENILLDTEGHVKLTDFGLSKERVDKDLTHTFCGTIEYMAPEILLRQGHGKSVDWWSLGTLMYDMLSGGPPFAGEDRKKTMELVLRGKFVLAPYLSREAKRLLKGLLRKNVAERLGSKEEDAEEIKAHPFFRNTNWDQVYARQVEPPFKPTLTSETDVSRFDPQFTNENPVESPDEGVPISASVCDVFEGFTYVDPQVHISMARDPWAFENTYLRRRRR 423
BLAST of Ribosomal protein S6 kinase vs. Ensembl Cavefish
Match: rps6kb1b (ribosomal protein S6 kinase B1 [Source:NCBI gene;Acc:103035647]) HSP 1 Score: 354.369 bits (908), Expect = 1.682e-116 Identity = 193/370 (52.16%), Postives = 249/370 (67.30%), Query Frame = 1
Query: 166 LNKDEYDSTSKSVDICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP--TTTDDSNCYWFENFSYVSPQVYLELSENGSF 1266
LN D+ + ++I E++VN + F+LL+ LGKGGYG+VF +KV G +G+ FAMKV+KKA ++ N K DT + ERNILE V HPF+V L +AFQT L+L+LEYL+GGELFMQLER+ ED A FYLAE ++ALGHLH G+IYRDLK EN+ML+ GHVKLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +VDWWS+G L+YDML G PF G NR + I K+ KL +P +LT + LLK LL ++ +RLG G D E++ H FFR INWD LAR+++PPF P L S +DVS FD S+ + SP +T +S F F+YV+P V + E SF
Sbjct: 35 LNMDD----CEKIEISEDSVNQGTESIRPECFELLRVLGKGGYGKVFQVRKVTGGGSGKIFAMKVLKKAMIVRNAK-DTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNNQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKRLLKRSASSRLGAGPGDATEVQTHPFFRHINWDDLLARKVEPPFKPFLQSAEDVSQFDSKFTSQTPVDSPDDSTLSESANQVFLGFTYVAPSVLENIKEKFSF 399
BLAST of Ribosomal protein S6 kinase vs. Ensembl Cavefish
Match: rps6kb1b (ribosomal protein S6 kinase B1 [Source:NCBI gene;Acc:103035647]) HSP 1 Score: 353.984 bits (907), Expect = 2.547e-116 Identity = 190/360 (52.78%), Postives = 245/360 (68.06%), Query Frame = 1
Query: 196 KSVDICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP--TTTDDSNCYWFENFSYVSPQVYLELSENGSF 1266
+ ++I E++VN + F+LL+ LGKGGYG+VF +KV G +G+ FAMKV+KKA ++ N K DT + ERNILE V HPF+V L +AFQT L+L+LEYL+GGELFMQLER+ ED A FYLAE ++ALGHLH G+IYRDLK EN+ML+ GHVKLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +VDWWS+G L+YDML G PF G NR + I K+ KL +P +LT + LLK LL ++ +RLG G D E++ H FFR INWD LAR+++PPF P L S +DVS FD S+ + SP +T +S F F+YV+P V + E SF
Sbjct: 44 EKIEISEDSVNQGTESIRPECFELLRVLGKGGYGKVFQVRKVTGGGSGKIFAMKVLKKAMIVRNAK-DTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNNQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKRLLKRSASSRLGAGPGDATEVQTHPFFRHINWDDLLARKVEPPFKPFLQSAEDVSQFDSKFTSQTPVDSPDDSTLSESANQVFLGFTYVAPSVLENIKEKFSF 402
BLAST of Ribosomal protein S6 kinase vs. Ensembl Cavefish
Match: ENSAMXT00000004157.2 (ribosomal protein S6 kinase B2 [Source:NCBI gene;Acc:103031203]) HSP 1 Score: 344.354 bits (882), Expect = 4.093e-113 Identity = 191/387 (49.35%), Postives = 255/387 (65.89%), Query Frame = 1
Query: 136 IELEANDSDNLNKDEYDST--------SKSVDICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP--TTTDDSNCYWFENFSYVSPQVYLELSENGS 1263
I+LE+ D + + Y+ T ++ V++ E VN +V F+LL LGKGGYG+VF +KV G+ G+ FAMKV++KA+++ N K DT + ER ILE V HPF+V L++AFQT L+L+LE L+GGELFMQLE++ ED A FYLAE TLALGHLHS G+IYRDLK EN+ML+ GH+KLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +VDWWS+G L++DM+ G+ PF G NR + I K+ K+ +P +LT + L+K LL KNP RLG G+ D +I++H FFR INWD L + ++PP+ P L S +DVS FD + + SP TT S + F F+YV+P V L E S
Sbjct: 7 IDLESEDVSDPEDEVYNFTVAESEPLETEEVELTSEVVNRDSERVGPDCFELLTVLGKGGYGKVFQVRKVQGSQMGKIFAMKVLRKAKIVRNAK-DTAHTRAEREILETVRHPFIVDLWYAFQTGGKLYLILECLSGGELFMQLEKEGIFMEDTACFYLAEITLALGHLHSNGIIYRDLKPENIMLNHEGHIKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILNRSGHNRAVDWWSLGALMFDMMTGSPPFTGENRKKTIDKILKCKICLPPYLTPDARDLIKKLLKKNPSQRLGSGKGDCADIQKHPFFRHINWDDLLHKRVEPPYRPSLQSDEDVSQFDSRFTRQTPVDSPDDTTLSGSADHAFAGFTYVAPSVLESLKEGFS 392
BLAST of Ribosomal protein S6 kinase vs. Ensembl Cavefish
Match: rps6kal (ribosomal protein S6 kinase a, like [Source:NCBI gene;Acc:337670]) HSP 1 Score: 310.071 bits (793), Expect = 6.100e-97 Identity = 158/328 (48.17%), Postives = 223/328 (67.99%), Query Frame = 1
Query: 292 YGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKERND-DELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISPTTTDDSNCY-WFENFSYVSPQVYLELSENGSFS 1269
+G+VFL +K+ G AG+ +AMKV+KKA L + TK ER+IL VNHPF+VKL++AFQT L+L+L++L GG++F +L ++ TE++ +FYLAE LAL HLH++G++YRDLK EN++LD GH+KLTDFGLSKE D D +SFCGTVEYMAPE++ RRGH S DWWS+G+L+++ML G PF G +R++ + + AKL +P+FL+ + LL+ L +NP RLG G VEEIKRH FF +I+W+K +EL+PPF P DD FD ++ SP +N + F+ FS+V+P LE S++ F+
Sbjct: 71 FGKVFLVRKIMGPDAGQLYAMKVLKKASLKVRDRVRTK---MERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVMFTEEDVKFYLAELALALDHLHNLGIVYRDLKPENILLDEAGHIKLTDFGLSKESVDQDRKAYSFCGTVEYMAPEVVNRRGHTQSADWWSLGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSLEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHAFFSTIDWNKLYRQELQPPFKPAAGKPDDTFCFDPEFTAKTPKDSPGIPPSANAHQLFKGFSFVAP-ASLEESKSSPFN 394 HSP 2 Score: 109.383 bits (272), Expect = 9.042e-25 Identity = 62/199 (31.16%), Postives = 109/199 (54.77%), Query Frame = 1
Query: 295 GQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVM-LDRYGH---VKLTDFGLSKE-RNDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGG 876
G + K+ + FA+K++ K++ +++ + ++ HP ++ L + ++LV E + GGEL ++ RQ +E EA L T + +LH GV++RDLK N++ +D G+ +++ DFG +K+ R D+ L + C T ++APE+L R+G+ + D WS+G+LLY ML G +PF G
Sbjct: 421 GSYSICKRCIHRVTAMEFAVKIIDKSKRDPSEEIEI--------LMRYGQHPNIITLKDVYDEGRFVYLVTELMKGGELLDKILRQKFFSEREASAVLYTITKTVDYLHCQGVVHRDLKPSNILYMDDSGNPDSIRICDFGFAKQLRGDNGLLLTPCYTANFVAPEVLMRQGYDAACDIWSLGVLLYTMLAGYTPFANG 611
BLAST of Ribosomal protein S6 kinase vs. Ensembl Cavefish
Match: rps6ka2 (ribosomal protein S6 kinase A2 [Source:NCBI gene;Acc:103036630]) HSP 1 Score: 310.842 bits (795), Expect = 6.122e-97 Identity = 173/364 (47.53%), Postives = 237/364 (65.11%), Query Frame = 1
Query: 166 LNKDEYDSTSKSVDICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKERND-DELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISPTTTDDSNCY-WFENFSYVSPQVYLELS 1251
L K E DS K +DI V K F+LLK LG+G YG+VFL +K+ G+ G+ +AMKV+KKA L K D + ER+IL VNHPF+VKL++AFQT L+L+L++L GG+LF +L ++ TE++ +FYLAE LAL HLHS+G+IYRDLK EN++LD GH+K+TDFGLSKE D D+ +SFCGT+EYMAPE++ RRGH S DWWS G+L+++ML G+ PF G +R + + + AKL +P+FL+ + LL+ L +NP RLG G VEEIKRH FF +I+W+K +E+KPPF P + +D FD S SP +N + F FS+V+ + E S
Sbjct: 29 LCKLEDDSILKEIDISNH-VKEGFEKADPSQFELLKVLGQGSYGKVFLVRKIKGSDTGQLYAMKVLKKATL---KVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEDGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSSEVQSLLRALFKRNPSNRLGAGPDGVEEIKRHHFFATIDWNKLYRKEIKPPFKPAVGRPEDTFHFDPEFTSRTPTDSPGVPPSANAHQLFRGFSFVATNLRPEQS 388 HSP 2 Score: 109.383 bits (272), Expect = 9.512e-25 Identity = 60/182 (32.97%), Postives = 107/182 (58.79%), Query Frame = 1
Query: 346 FAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVM-LDRYG---HVKLTDFGLSKE-RNDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGG 876
+A+K+++K++ +++ + +L HP ++ L + ++LV+E + GGEL ++ RQ +E EA L T + +LHS GV++RDLK N++ +D G +++ DFG +K+ R ++ L + C T ++APE+L+++G+ + D WS+GILLY ML G +PF G
Sbjct: 441 YAVKIIEKSKKDPSEEIEI--------LLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQKGFSEREASAVLCTITKTVEYLHSQGVVHRDLKPSNILYVDETGDPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKKQGYDAACDIWSLGILLYTMLAGFTPFANG 614
BLAST of Ribosomal protein S6 kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008480.1 (pep scaffold:Pmarinus_7.0:GL482122:191709:206473:1 gene:ENSPMAG00000007654.1 transcript:ENSPMAT00000008480.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 248.44 bits (633), Expect = 1.665e-76 Identity = 140/352 (39.77%), Postives = 212/352 (60.23%), Query Frame = 1
Query: 199 SVDICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHS-IGVIYRDLKSENVMLDRYGHVKLTDFGLSKERNDDELT-HSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISPT-------TTDDSNCYWFENFSYVS 1227
S + + ++ P KVT ++FD LK LGKG +G+V L ++ G+Y+AMK++KK ++ K++ + +TE +L+ HPFL L ++FQT+ L V+EY+ GGELF L R+ +ED RFY AE AL +LH+ V+YRDLK EN+MLD+ GH+K+ DFGL KE D T +FCGT EY+APE+L+ +G +VDWW +G+++Y+M+ G PF + ++ + + ++ PR L++ + LL LL K+PK RLGGG D +EI RH FF I W R++ PPF P+++S D FD+ ++ I+P + D+ F FSY +
Sbjct: 130 STEQMDTILSKPKSKVTMNNFDYLKLLGKGTFGKVILVRE---KATGQYYAMKILKKEVIVA--KDEVAHTLTENRVLQTTKHPFLTLLKYSFQTHDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHTEKNVVYRDLKLENLMLDKDGHIKIADFGLCKEGITDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIRFPRTLSNDARALLSGLLKKDPKQRLGGGVDDAKEIMRHSFFAGIIWQDVYDRKMTPPFKPQVASETDTRYFDEEFTAQTITITPPDRFDSMESLDNERRPHFPQFSYCA 476
BLAST of Ribosomal protein S6 kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006766.1 (pep scaffold:Pmarinus_7.0:GL478342:9725:27922:-1 gene:ENSPMAG00000006086.1 transcript:ENSPMAT00000006766.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 236.498 bits (602), Expect = 1.323e-72 Identity = 133/315 (42.22%), Postives = 202/315 (64.13%), Query Frame = 1
Query: 256 DFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNIL-EAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKERNDDE-LTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISPTTTDDSN 1194
DFD L LGKG +G+V LAK + G ++A+KV+KK+ ++ +K + K+ M ERN+L + V HPFLV L+++FQ+ L+ V++Y+ GGELF L+RQ + E A+FY AE A+G+LHS+ ++YRDLK EN++LD GH+ LTDFGL KE D T +FCGT EY+APE+L++ + +VDWW +G +LY+ML G PF N Q+ + + + L++ T++ +L+ LL+K+P RL G D+ EIK H FF +INW+ A+ + P+ P +S D+ FD +EP +S + D++
Sbjct: 91 DFDFLTVLGKGSFGKVLLAKHKSD---GIFYAVKVMKKSIIL--QKKEEKHIMAERNVLVKNVRHPFLVGLHYSFQSADKLYFVMDYVNGGELFFHLQRQGSFPESRAQFYAAEIGSAIGYLHSLNIVYRDLKPENILLDYQGHIVLTDFGLCKEGIDPHSTTCTFCGTPEYLAPEVLKKHPYDRTVDWWCLGCVLYEMLYGLPPFYSKNLKQMYESILHQPLQLRPCTTNAAISVLEGLLHKDPHQRL-GATSDILEIKNHVFFSTINWNDLDAKRIPSPYNPGVSGPCDLHNFDPAFTAEPLSMSMAQSSDTS 399
BLAST of Ribosomal protein S6 kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001814.1 (pep scaffold:Pmarinus_7.0:GL481074:830:17391:1 gene:ENSPMAG00000001637.1 transcript:ENSPMAT00000001814.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 204.527 bits (519), Expect = 4.108e-62 Identity = 100/268 (37.31%), Postives = 169/268 (63.06%), Query Frame = 1
Query: 334 AGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKERNDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFD 1137
G++ ++K K+ +++ K+ ++ + E+ IL+A++ PFLV+L ++F+ N +L++VLEY+ GGE+F L R +E +RFY A+ LA +LHS+ +IYRDLK EN+++D+ G++++TDFG +K T + CGT EY+APEI+ +G+ +VDWW++G+L+Y+M G PF Q+ +K+ + K++ P + K LL+NLL + R G + V +IK H +F + +W R+++ PFIP+ D S FD
Sbjct: 3 VGQHVSLKATKRTKVVKLKQ--VEHTLNEKRILQAISFPFLVRLEYSFKDNSNLYMVLEYVPGGEMFSHLRRIGRFSEPHSRFYAAQIVLAFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGR--TWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFSTTDWIAIYQRKVEAPFIPKCKGPGDASNFD 266
BLAST of Ribosomal protein S6 kinase vs. Ensembl Sea Lamprey
Match: PRKCD (protein kinase C delta [Source:HGNC Symbol;Acc:HGNC:9399]) HSP 1 Score: 209.534 bits (532), Expect = 2.880e-61 Identity = 115/276 (41.67%), Postives = 167/276 (60.51%), Query Frame = 1
Query: 292 YGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNIL-EAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHT--LTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPEL 1107
+G+V LA+ G++FA+K +KK ++ +D + M E+ +L A HPFL L FQT LF V+E+L GG+L ++ + L RFY AE L LHS +IYRDLK +NV+LDR GHVK+ DFG+ KE L +FCGT +Y+APEIL R +G SVDWWSMG+L+Y+MLIG SPF G + ++ + + PR+L+DS +++L L ++ RLG V +I+ H FF++I+W AR++ PPF P++
Sbjct: 263 FGKVMLAELKE---QGKFFAIKALKKEVVLMG--DDVECTMVEKRVLLMACEHPFLTHLCGTFQTKEHLFFVMEFLTGGDLMFHIQDKGKFDLPTGTNRFYAAEVICGLQFLHSHNIIYRDLKLDNVLLDREGHVKIADFGMCKEHVGAGNLATTFCGTPDYIAPEILLGRAYGTSVDWWSMGVLIYEMLIGQSPFYGSDEDELFEAIKGHTPHYPRWLSDSSRNILSCLFERDHTKRLGA----VGDIRLHPFFKNIDWPSLEARKITPPFKPKV 529
BLAST of Ribosomal protein S6 kinase vs. Ensembl Sea Lamprey
Match: PRKCD (protein kinase C delta [Source:HGNC Symbol;Acc:HGNC:9399]) HSP 1 Score: 199.904 bits (507), Expect = 1.267e-60 Identity = 115/274 (41.97%), Postives = 164/274 (59.85%), Query Frame = 1
Query: 298 QVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILE-AVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSS 1113
QVFLA+ + +FA+K +KK +I + +D + + E+ IL A HP+L LY FQT L V+EYL GG+L ++ + D A FY AE L LH G+IYRDLK +N++LD+ GHVK+ DFG+ KE D +FCGT +Y+APEI+ + + SVDWWS G+LLY+MLIG SPF G + ++ + + + PR++T + +L LL + P RLG EI++H FFR+INW+ REL+PPF P + S
Sbjct: 1 QVFLAEL--KSRPRNFFAIKALKKDVVIMS--DDVECTLVEKRILSLAWGHPYLAHLYSTFQTKEHLMFVMEYLNGGDLMFHIQVKGRFEIDRATFYAAEIVSGLQFLHDQGIIYRDLKLDNILLDKDGHVKIADFGMCKENIVGDVRAGTFCGTPDYIAPEIVIGQKYNCSVDWWSFGVLLYEMLIGQSPFRGDDEEELFESIRTSVPYYPRWITKDSRDILPLLLEREPMKRLGV----TGEIRQHPFFRTINWEALEKRELEPPFKPRVVS 266
BLAST of Ribosomal protein S6 kinase vs. Ensembl Yeast
Match: TPK1 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; phosphorylates and inhibits Whi3p to promote G1/S phase passage; partially redundant with Tpk2p and Tpk3p; phosphorylates pre-Tom40p, which impairs its import into mitochondria under non-respiratory conditions; TPK1 has a paralog, TPK3, that arose from the whole genome duplication [Source:SGD;Acc:S000003700]) HSP 1 Score: 219.935 bits (559), Expect = 8.903e-67 Identity = 117/301 (38.87%), Postives = 187/301 (62.13%), Query Frame = 1
Query: 241 KVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKERNDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSS-RDDVSLFDK 1140
K + DF +L+ LG G +G+V L + G Y+AMKV+KK ++ K+ ++ ER +L V HPF+++++ FQ +F++++Y+ GGELF L + A+FY AE LAL +LHS +IYRDLK EN++LD+ GH+K+TDFG +K D +T++ CGT +Y+APE++ + + S+DWWS GIL+Y+ML G +PF N + +K+ NA+L+ P F + K LL L+ ++ RLG + E++K H +F+ + W+K L+R ++ P+ P + + D S FDK
Sbjct: 81 KYSLQDFQILRTLGTGSFGRVHL---IRSRHNGRYYAMKVLKKEIVVRLKQ--VEHTNDERLMLSIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPD--VTYTLCGTPDYIAPEVVSTKPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPPFFNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWFKEVVWEKLLSRNIETPYEPPIQQGQGDTSQFDK 374
BLAST of Ribosomal protein S6 kinase vs. Ensembl Yeast
Match: TPK2 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase; relocalizes to the cytosol in response to hypoxia [Source:SGD;Acc:S000006124]) HSP 1 Score: 218.009 bits (554), Expect = 3.068e-66 Identity = 119/326 (36.50%), Postives = 196/326 (60.12%), Query Frame = 1
Query: 241 KVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKERNDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSR-DDVSLFDKNIVSEPCMISPTTTDDSNCYWFENF 1215
K T HDF +++ LG G +G+V L + V+ G Y+A+KV+KK +++ K+ ++ ER +L+ V HPFL++++ FQ ++F+V++Y+ GGELF L + A+FY AE LAL +LH+ +IYRDLK EN++LDR GH+K+TDFG +KE +T + CGT +Y+APE++ + + SVDWWS+G+L+Y+ML G +PF + +K+ K+ P + LL L+ + R+G + +IK H +F + W++ LA++++ P+ P ++S D SLFD+ E + DD +F++F
Sbjct: 64 KYTLHDFQIMRTLGTGSFGRVHLVRSVHN---GRYYAIKVLKKQQVVKMKQ--VEHTNDERRMLKLVEHPFLIRMWGTFQDARNIFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVILALEYLHAHNIIYRDLKPENILLDRNGHIKITDFGFAKEVQ--TVTWTLCGTPDYIAPEVITTKPYNKSVDWWSLGVLIYEMLAGYTPFYDTTPMKTYEKILQGKVVYPPYFHPDVVDLLSKLITADLTRRIGNLQSGSRDIKAHPWFSEVVWERLLAKDIETPYEPPITSGIGDTSLFDQ--YPEEQLDYGIQGDDPYAEYFQDF 380
BLAST of Ribosomal protein S6 kinase vs. Ensembl Yeast
Match: TPK3 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication [Source:SGD;Acc:S000001649]) HSP 1 Score: 215.698 bits (548), Expect = 3.884e-65 Identity = 115/301 (38.21%), Postives = 187/301 (62.13%), Query Frame = 1
Query: 241 KVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKERNDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSS-RDDVSLFDK 1140
K + DF +L+ LG G +G+V L + + G ++A+K +KK ++ K+ ++ ER +L V+HPF+++++ FQ + +F+V++Y+ GGELF L + A+FY AE LAL +LHS +IYRDLK EN++LD+ GH+K+TDFG +K D +T++ CGT +Y+APE++ + + SVDWWS G+L+Y+ML G +PF N + + + NA+LK P F + LLK L+ ++ RLG + E++K H +F + W+K LAR ++ P+ P + + D S FD+
Sbjct: 82 KYSLSDFQILRTLGTGSFGRVHLIRSNHN---GRFYALKTLKKHTIVKLKQ--VEHTNDERRMLSIVSHPFIIRMWGTFQDSQQVFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPD--VTYTLCGTPDYIAPEVVSTKPYNKSVDWWSFGVLIYEMLAGYTPFYNSNTMKTYENILNAELKFPPFFHPDAQDLLKKLITRDLSERLGNLQNGSEDVKNHPWFNEVIWEKLLARYIETPYEPPIQQGQGDTSQFDR 375
BLAST of Ribosomal protein S6 kinase vs. Ensembl Yeast
Match: SCH9 (AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan [Source:SGD;Acc:S000001248]) HSP 1 Score: 219.935 bits (559), Expect = 2.948e-63 Identity = 133/300 (44.33%), Postives = 193/300 (64.33%), Query Frame = 1
Query: 253 HDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNIL---EAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKERNDDELTHSFCGTVEYMAPE-ILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPR-FLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFD 1137
DF++L+ LGKG +GQV+ KK + +AMKV+ K ++ KKN+ + + ERNIL + + PF+V L F+FQT L+LV +Y++GGELF L+++ +ED A+FY+AE LAL HLH ++YRDLK EN++LD G++ L DFGLSK D T++FCGT EY+APE +L G+ VD+WS+G+L+++M G SPF N ++ QK+ K+K PR L+ G+ +K LLN+NPK RLG + D E++ H FF I+W+ +++ PPF P L S D S FD
Sbjct: 410 QDFEVLRLLGKGTFGQVYQVKKKD---TQRIYAMKVLSKKVIV--KKNEIAHTIGERNILVTTASKSSPFIVGLKFSFQTPTDLYLVTDYMSGGELFWHLQKEGRFSEDRAKFYIAELVLALEHLHDNDIVYRDLKPENILLDANGNIALCDFGLSKADLKDR-TNTFCGTTEYLAPELLLDETGYTKMVDFWSLGVLIFEMCCGWSPFFAENNQKMYQKIAFGKVKFPRDVLSQEGRSFVKGLLNRNPKHRLGAID-DGRELRAHPFFADIDWEALKQKKIPPPFKPHLVSETDTSNFD 702
BLAST of Ribosomal protein S6 kinase vs. Ensembl Yeast
Match: PKC1 (Protein serine/threonine kinase; essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC) [Source:SGD;Acc:S000000201]) HSP 1 Score: 211.846 bits (538), Expect = 1.237e-59 Identity = 121/321 (37.69%), Postives = 184/321 (57.32%), Query Frame = 1
Query: 292 YGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNIL---EAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKERNDDEL-----THSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMIS--PTTTDDSNCYWFENFSYV 1224
+G+V L+K N A+KV+KK +I N +D + A E+ + HPFL LY +FQT + ++ +E++ GG+L ++ Q L+ A+FY AE LAL + H GVIYRDLK EN++L GH+K+ D+GL K DE+ T +FCGT E+MAPEIL+ + + +VDWW+ G+LLY ML+ SPF G + +V + + P + + + LL K+P+ RLG G +D +E+ FFR+IN+D L +KPP+IPE+ S +D S F++ S P ++ P+ S F FS++
Sbjct: 835 FGKVILSKSKN---TDRLCAIKVLKKDNIIQN--HDIESARAEKKVFLLATKTKHPFLTNLYCSFQTENRIYFAMEFIGGGDLMWHVQNQR-LSVRRAKFYAAEVLLALKYFHDNGVIYRDLKLENILLTPEGHIKIADYGLCK----DEMWYGNRTSTFCGTPEFMAPEILKEQEYTKAVDWWAFGVLLYQMLLCQSPFSGDDEDEVFNAILTDEPLYPIDMAGEIVQIFQGLLTKDPEKRLGAGPRDADEVMEEPFFRNINFDDILNLRVKPPYIPEIKSPEDTSYFEQEFTSAPPTLTPLPSVLTTSQQEEFRGFSFM 1145
BLAST of Ribosomal protein S6 kinase vs. Ensembl Nematostella
Match: EDO41166 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S521]) HSP 1 Score: 350.132 bits (897), Expect = 1.985e-116 Identity = 196/401 (48.88%), Postives = 259/401 (64.59%), Query Frame = 1
Query: 127 INGIELEANDSDNLNKDEYDSTS------------KSVDICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKERN-DDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP--TTTDDSNCYWFENFSYVSPQVYLELSENGSFSRQRTR 1284
IN + L A + + + DE+D +++ + EETVNP KV F+LLK LGKGGYG+VFL KK +G + FAMKV+KKA +I ++K DT + ERNILE V HPF+V L +AFQT L+L+LEYL+GGELFMQLER+ ED A FYL+E ++AL HLH G++YRDLK EN++LD GHVKLTDFGL KE ++ LTH+FCGT+EYMAPEIL R GHG +VDWWS+G L+YDML G PF NR + I K+ KL IP +LT K ++ LL ++P+ARLGG D IK H FFR I W+ LA++++PPF P +S +DVS FD + + SP + +S F+ F+YV+P V L + +FS + R
Sbjct: 9 INDVALAAGEDELSSDDEFDEGQVYDEPMDGDERMETLQLSEETVNPKDEKVGPESFELLKVLGKGGYGKVFLVKKNHGHSKEKIFAMKVLKKAAIIRSQK-DTAHTKAERNILECVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFLEDTACFYLSEISMALEHLHKQGIVYRDLKPENILLDANGHVKLTDFGLCKESIFENSLTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMYDMLTGTPPFCADNRKKTIDKILKGKLIIPPYLTPEAKDFIRKLLKRHPQARLGGMAGDANPIKAHSFFRHICWEDLLAKKVEPPFRPSISGEEDVSQFDSKFTRQTPVDSPDDSMLSESASNIFQGFTYVAPSVLESLCRSDNFSPWKVR 408
BLAST of Ribosomal protein S6 kinase vs. Ensembl Nematostella
Match: EDO31895 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SWM6]) HSP 1 Score: 315.079 bits (806), Expect = 1.376e-100 Identity = 167/345 (48.41%), Postives = 227/345 (65.80%), Query Frame = 1
Query: 241 KVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKERNDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISPTTTDDSNCY-WFENFSYVSPQVYLELSENGSFSR 1272
K F+LLK LG+G +G+VFL +KV GA AG +AMKV+KKA L K D M ER+IL V HPF+V+L +AFQT ++L+L++L GG+LF +L ++ TE++ +FYLAE LAL HLH +G+IYRDLK EN++LD GHV LTDFGLSKE D+ T+SFCGTVEYMAPE++ RRGH + DWWS G+L+++ML G+ PF G +R + + AKL +P+FLT + LL+ L +NP RLG G+ +E+IK+H FF +INW+ RE+KPPF P DD FD S+ SP + C+ F FSYV+P + +E+ G +R
Sbjct: 3 KADPSQFELLKVLGQGSFGKVFLVRKVIGADAGTLYAMKVLKKATL---KVRDRMRTMKERDILVDVQHPFIVRLNYAFQTEGKVYLILDFLRGGDLFTRLSKEIMFTEEDVKFYLAELALALDHLHGLGIIYRDLKPENILLDASGHVALTDFGLSKESEHDQKTYSFCGTVEYMAPEVVNRRGHSQAADWWSYGVLMFEMLTGSLPFQGKDRKDTMNMILKAKLGMPQFLTPEAQSLLRQLFKRNPLNRLGAGDLGIEDIKKHPFFSTINWELLYKREIKPPFKPAAGRADDAFYFDPEFTSKTPQDSPAVPPSATCHQLFRGFSYVAPDI-VEVETRGPAAR 343 HSP 2 Score: 103.99 bits (258), Expect = 1.352e-23 Identity = 68/207 (32.85%), Postives = 113/207 (54.59%), Query Frame = 1
Query: 319 VNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVML-DRYG---HVKLTDFGLSKE-RNDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGG---NRSQVIQKVTNAK 915
VN A EY A+K+ +K K D M +L +HP +V L A++ +++V+E + GGEL ++ + L+E EA + T + LH GV++RDLK N+M D G +++ DFG +K+ R + L + C T ++APE+L+++G+ + D WS+G+LLY ML G +PF G S +++++ K
Sbjct: 374 VNKADGKEY-AVKIFEKP------KKDPSEEM--EILLRFGHHPNIVHLRDAYEAGKQVYIVMELMRGGELLDRILKHKCLSEREAGNIMYTLTSTIAFLHEEGVVHRDLKPSNIMYADDSGTPESLRIVDFGFAKQMRATNGLLMTPCYTANFVAPEVLKKQGYDAACDIWSLGVLLYTMLSGLTPFAVGPEDTPSVILKRIGEGK 571
BLAST of Ribosomal protein S6 kinase vs. Ensembl Nematostella
Match: EDO37800 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SEW2]) HSP 1 Score: 261.151 bits (666), Expect = 5.124e-82 Identity = 157/387 (40.57%), Postives = 234/387 (60.47%), Query Frame = 1
Query: 103 DLKLKCDLINGIELEANDSDNLNKDEYDSTSKSVDICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNIL-EAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKERNDDE-LTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISPTTTDDSNCY---------WFENFSYVSP 1230
D++ L N +AND D + D+ + +D+ E NP K DF LK +GKG +G+VFL+K +++A+KV+ K+ + K+N+ K+ M ERN+L + V HPFLV L+++FQT L+ VL+Y+ GGELF L+R+ E ARFY AE A+G+LH + +IYRDLK EN++LD GH+ LTDFGL KE D T +FCGT EY+APE+L+++ + SVDWW +G +LY+M+ G PF + +++ + + L++ ++ S +H+L+ LL K+ RLG GE D E+I+ H FFRSINW + +AR ++PP+ P +S + D+ FD V EP S + DSN F F+YV+P
Sbjct: 27 DVREFLSLDNPKNAQANDEDEQPGSD-DADVEKIDLGESN-NP---KAKPSDFLFLKVIGKGSFGKVFLSKN---KQEDKFYAIKVLNKSAI--RKRNEAKHIMAERNVLVQNVTHPFLVGLHYSFQTKDKLYFVLDYVNGGELFFHLQRERYFPESRARFYAAEIASAIGYLHGLQIIYRDLKPENILLDSKGHIVLTDFGLCKEGIDRSGTTSTFCGTPEYLAPEVLRKQDYDKSVDWWCLGAVLYEMMYGLPPFYSRDTAEMYDNILHKPLRLRTNISQSARHILEGLLQKDKTKRLGSGEGDFEDIRTHSFFRSINWQQLVARGIEPPYNPNVSGQLDLKHFDPEFVREPVPGSVGKSADSNFVSASVDDPDDAFVGFTYVAP 403
BLAST of Ribosomal protein S6 kinase vs. Ensembl Nematostella
Match: EDO39163 (Ribosomal protein S6 kinase [Source:UniProtKB/TrEMBL;Acc:A7SAZ2]) HSP 1 Score: 253.832 bits (647), Expect = 8.301e-76 Identity = 149/342 (43.57%), Postives = 211/342 (61.70%), Query Frame = 1
Query: 241 KVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNH-PFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKE---RNDDELTHSFCGTVEYMAPEILQ--RRGHGPSVDWWSMGILLYDMLIGNSPF-VGG---NRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISPTTTDDSNCYWFENFSYVSPQV 1236
KV +F+LL+ LG G YG+VFLA+K G G FAMKV+KKA ++ K ++ TER +LEAV PFLV L++AFQT L L+++Y+ GGELF L ++ TEDE R Y+ E +AL HLH +G+IYRD+K EN++LD+ GHV LTDFGLSKE N E +SFCGT+EYMAPE+++ RGH +VDWWS+G+L+Y++L G SPF V G ++S++ +++ + +P L+ LL LL K+PK RLG K E+K H FF++ +W + + PF P + DVS F + SP + F +S+V+P +
Sbjct: 10 KVGIENFELLRVLGTGAYGKVFLARKRGGHHDGRLFAMKVLKKATIVQKAKT-AEHTRTERQVLEAVRRCPFLVTLHWAFQTEAKLHLIMDYVNGGELFTHLYQREKFTEDEVRLYIGEIVVALDHLHQLGIIYRDIKLENILLDKDGHVVLTDFGLSKEFAAPNSGERAYSFCGTIEYMAPEVVKGGSRGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQSEISKRILHNNPPMPHDLSAEAIDLLHKLLQKDPKKRLGA--KGAHELKAHPFFKAFDWADLAEKRIPAPFKPRIRDELDVSNFSEEFTDMAPTYSPAAVPKTADRVFRGYSFVAPSI 348 HSP 2 Score: 101.679 bits (252), Expect = 1.092e-22 Identity = 52/149 (34.90%), Postives = 82/149 (55.03%), Query Frame = 1
Query: 442 NHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVML---DRYGHVKLTDFGLSKERNDDELTHSFCGTVEYMAPEILQR----RGHGPSVDWWSMGILLYDMLIGNSPF 867
HP +V LY +Q +LV+E LAGGEL ++ ++ TE A + + A+ +H GV++RDLK EN++ +K+ DFG + + + + + C T+ Y APE+L + G+ S D WS+G++LY ML G PF
Sbjct: 445 GHPNIVTLYDVYQDEFHTYLVMELLAGGELLERIRKKKMFTESAASVIMRKIVSAVEFMHQRGVVHRDLKPENLLFVDNSEDAEIKIVDFGFACVKPEAQQLQTPCFTLSYAAPEVLDQTVSNSGYDESCDLWSLGVILYTMLSGQVPF 593
BLAST of Ribosomal protein S6 kinase vs. Ensembl Nematostella
Match: EDO35585 (Protein kinase C [Source:UniProtKB/TrEMBL;Acc:A7SL27]) HSP 1 Score: 232.646 bits (592), Expect = 4.001e-68 Identity = 136/337 (40.36%), Postives = 203/337 (60.24%), Query Frame = 1
Query: 241 KVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILE-AVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVE-EIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISPTTTD---DSNCYWFENFSYVSPQ 1233
K+T DF +K LGKG +G+V LA++ E +A+K++KK ++ + +D + M ER +L + HPFL L+ +FQT LF V+EY+ GG+L Q+++ E+ +RFY AE LAL LH GVIYRDLK +NV+LD GH+KL DFG+ KE + T +FCGT +Y+APEILQ + +G SVDWW++G+L+Y+M+ G PF N + + + + + P +L+ +LK + KN RLG E I+ H FFR IN++K AR++ PPF P++ SR DV FD + E ++PT + + + F FS+V+P
Sbjct: 377 KMTLKDFTFIKVLGKGSFGKVLLAERKG---TDEVYAIKILKKESVLQD--DDVECTMIERRVLALSAGHPFLTSLHSSFQTVERLFFVMEYVNGGDLMFQIQKSRKFDENRSRFYAAEVVLALQFLHQNGVIYRDLKLDNVLLDADGHIKLADFGMCKENMAPGKTTTTFCGTPDYIAPEILQEQPYGFSVDWWALGVLMYEMMAGQPPFEAENEEDLFESILHDDVLYPVWLSREAVSILKGFMTKNYLKRLGCTPTSTESSIREHAFFRLINFEKLEARQINPPFKPKIRSRTDVGNFDTDFTKEEPKLTPTDRNVIVNIDQREFRGFSFVNPH 708
BLAST of Ribosomal protein S6 kinase vs. Ensembl Medaka
Match: rps6kb1b (ribosomal protein S6 kinase beta-1-like [Source:NCBI gene;Acc:101174764]) HSP 1 Score: 360.533 bits (924), Expect = 2.864e-119 Identity = 195/374 (52.14%), Postives = 250/374 (66.84%), Query Frame = 1
Query: 154 DSDNLNKDEYDSTSKSVDICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP--TTTDDSNCYWFENFSYVSPQVYLELSENGSF 1266
D D ++ D ++ ++I E+ VN + F+LL+ LGKGGYG+VF +KV GA AG+ FAMKV+KKA ++ N K DT + ERNILE V HPF+V L +AFQT L+L+LEYL+GGELFMQLER+ ED A FYLAE ++ALGHLH G+IYRDLK EN+ML+ GHVKLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +VDWWS+G L+YDML G PF G NR + I K+ KL +P +LT + LLK LL + +RLG G D E++ H FFR INW+ LAR+++PPF P L S DDVS FD S+ + SP +T +S F F+YV+P V + E SF
Sbjct: 8 DLDQPEENVSDDENEEIEISEDNVNQGTESIRPECFELLRVLGKGGYGKVFQVRKVVGAAAGKIFAMKVLKKAMIVRNAK-DTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNSQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKRLLKRTASSRLGAGPGDATEVQAHPFFRHINWEDLLARKVEPPFKPVLQSADDVSQFDSKFTSQTPVDSPDDSTLSESANQAFLGFTYVAPSVLENMKERFSF 380
BLAST of Ribosomal protein S6 kinase vs. Ensembl Medaka
Match: rps6kb1b (ribosomal protein S6 kinase beta-1-like [Source:NCBI gene;Acc:101174764]) HSP 1 Score: 356.295 bits (913), Expect = 3.087e-117 Identity = 192/360 (53.33%), Postives = 244/360 (67.78%), Query Frame = 1
Query: 196 KSVDICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP--TTTDDSNCYWFENFSYVSPQVYLELSENGSF 1266
+ ++I E+ VN + F+LL+ LGKGGYG+VF +KV GA AG+ FAMKV+KKA ++ N K DT + ERNILE V HPF+V L +AFQT L+L+LEYL+GGELFMQLER+ ED A FYLAE ++ALGHLH G+IYRDLK EN+ML+ GHVKLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +VDWWS+G L+YDML G PF G NR + I K+ KL +P +LT + LLK LL + +RLG G D E++ H FFR INW+ LAR+++PPF P L S DDVS FD S+ + SP +T +S F F+YV+P V + E SF
Sbjct: 49 EQIEISEDNVNQGTESIRPECFELLRVLGKGGYGKVFQVRKVVGAAAGKIFAMKVLKKAMIVRNAK-DTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNSQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKRLLKRTASSRLGAGPGDATEVQAHPFFRHINWEDLLARKVEPPFKPVLQSADDVSQFDSKFTSQTPVDSPDDSTLSESANQAFLGFTYVAPSVLENMKERFSF 407
BLAST of Ribosomal protein S6 kinase vs. Ensembl Medaka
Match: rps6kb1a (ribosomal protein S6 kinase beta-1 [Source:NCBI gene;Acc:101174287]) HSP 1 Score: 355.525 bits (911), Expect = 3.266e-117 Identity = 196/373 (52.55%), Postives = 250/373 (67.02%), Query Frame = 1
Query: 157 SDNLNKDEYDSTSKSVDICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP--TTTDDSNCYWFENFSYVSPQVYLELSENGSF 1266
+ NL D K ++ E VN ++ F+LLK LGKGGYG+VF +KV+GA +G+ +AMKV+KKA ++ N K DT + ERNILE V HPF+V L +AFQT L+L+LEYL+GGELFMQLER+ ED A FYLAE ++ALGHLH G+IYRDLK EN+ML+ GHVKLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +VDWWS+G L+YDML G PF G NR + I K+ KL +P +LT + LLK LL ++ +RLGGG D E++ H FFR INWD LAR+++PPF P L S DDVS FD S+ + SP +T +S F F+YV+P V + E SF
Sbjct: 6 TTNLRMGNMDDCEK-FELSENNVNKGTEQIRPECFELLKVLGKGGYGKVFQVRKVSGASSGKIYAMKVLKKAMIVRNAK-DTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNDSGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLSLPPYLTQEARDLLKKLLKRSASSRLGGGPGDAAEVQVHPFFRHINWDDLLARKVEPPFKPFLQSADDVSQFDSKFTSQTPVDSPDDSTLSESANQVFLGFTYVAPSVLENVKEKFSF 376
BLAST of Ribosomal protein S6 kinase vs. Ensembl Medaka
Match: rps6kb1a (ribosomal protein S6 kinase beta-1 [Source:NCBI gene;Acc:101174287]) HSP 1 Score: 354.755 bits (909), Expect = 1.010e-116 Identity = 197/381 (51.71%), Postives = 254/381 (66.67%), Query Frame = 1
Query: 133 GIELEANDSDNLNKDEYDSTSKSVDICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP--TTTDDSNCYWFENFSYVSPQVYLELSENGSF 1266
G +E S + N D+ + ++ E VN ++ F+LLK LGKGGYG+VF +KV+GA +G+ +AMKV+KKA ++ N K DT + ERNILE V HPF+V L +AFQT L+L+LEYL+GGELFMQLER+ ED A FYLAE ++ALGHLH G+IYRDLK EN+ML+ GHVKLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +VDWWS+G L+YDML G PF G NR + I K+ KL +P +LT + LLK LL ++ +RLGGG D E++ H FFR INWD LAR+++PPF P L S DDVS FD S+ + SP +T +S F F+YV+P V + E SF
Sbjct: 11 GEYMEQCSSFDFNMDDCEK----FELSENNVNKGTEQIRPECFELLKVLGKGGYGKVFQVRKVSGASSGKIYAMKVLKKAMIVRNAK-DTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNDSGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLSLPPYLTQEARDLLKKLLKRSASSRLGGGPGDAAEVQVHPFFRHINWDDLLARKVEPPFKPFLQSADDVSQFDSKFTSQTPVDSPDDSTLSESANQVFLGFTYVAPSVLENVKEKFSF 386
BLAST of Ribosomal protein S6 kinase vs. Ensembl Medaka
Match: rps6kb1a (ribosomal protein S6 kinase beta-1 [Source:NCBI gene;Acc:101174287]) HSP 1 Score: 354.369 bits (908), Expect = 2.698e-116 Identity = 197/381 (51.71%), Postives = 254/381 (66.67%), Query Frame = 1
Query: 133 GIELEANDSDNLNKDEYDSTSKSVDICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISP--TTTDDSNCYWFENFSYVSPQVYLELSENGSF 1266
G +E S + N D+ + ++ E VN ++ F+LLK LGKGGYG+VF +KV+GA +G+ +AMKV+KKA ++ N K DT + ERNILE V HPF+V L +AFQT L+L+LEYL+GGELFMQLER+ ED A FYLAE ++ALGHLH G+IYRDLK EN+ML+ GHVKLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +VDWWS+G L+YDML G PF G NR + I K+ KL +P +LT + LLK LL ++ +RLGGG D E++ H FFR INWD LAR+++PPF P L S DDVS FD S+ + SP +T +S F F+YV+P V + E SF
Sbjct: 28 GEYMEQCSSFDFNMDD----CEKFELSENNVNKGTEQIRPECFELLKVLGKGGYGKVFQVRKVSGASSGKIYAMKVLKKAMIVRNAK-DTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNDSGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLSLPPYLTQEARDLLKKLLKRSASSRLGGGPGDAAEVQVHPFFRHINWDDLLARKVEPPFKPFLQSADDVSQFDSKFTSQTPVDSPDDSTLSESANQVFLGFTYVAPSVLENVKEKFSF 403
BLAST of Ribosomal protein S6 kinase vs. Planmine SMEST
Match: SMESG000068122.1 (SMESG000068122.1) HSP 1 Score: 823.543 bits (2126), Expect = 0.000e+0 Identity = 441/441 (100.00%), Postives = 441/441 (100.00%), Query Frame = 1
Query: 55 MAIVNASSIEGLKIFKDLKLKCDLINGIELEANDSDNLNKDEYDSTSKSVDICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKERNDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISPTTTDDSNCYWFENFSYVSPQVYLELSENGSFSRQRTRXXXXXXXXXXXXXXXXQTTQFLFEEDFVDLK 1377
MAIVNASSIEGLKIFKDLKLKCDLINGIELEANDSDNLNKDEYDSTSKSVDICEETVNPPGVKVTSHDFDLLKKLGKGGYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKERNDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGKHLLKNLLNKNPKARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISPTTTDDSNCYWFENFSYVSPQVYLELSENGSFSRQRTRSGVSHSSSSPGDSHHHQTTQFLFEEDFVDLK
Sbjct: 1 MAIVNASSIEGLKIFKDLKLKCDLINGIELEANDSDNLNKDEYDSTSKSVDICEETVNPPGVKVTSHDFDLLKKLGKGGYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKERNDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGKHLLKNLLNKNPKARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISPTTTDDSNCYWFENFSYVSPQVYLELSENGSFSRQRTRSGVSHSSSSPGDSHHHQTTQFLFEEDFVDLK 441
BLAST of Ribosomal protein S6 kinase vs. Planmine SMEST
Match: SMESG000004478.1 (SMESG000004478.1) HSP 1 Score: 328.946 bits (842), Expect = 3.609e-106 Identity = 192/408 (47.06%), Postives = 269/408 (65.93%), Query Frame = 1
Query: 172 KDEYDSTSKSVDICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVN-GAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKERNDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVG-GNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRS--INWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISPTTTDDSNCY--WFENFSYVSPQVYLE-LSENGSFSRQRTRXXXXXXXXXXXXXXXXQTTQFLFEEDFVDL 1374
K E D +SV+IC+ VNP GVK++ DF +L +G+GGYG+VFL +K + G + +AMKV+KKAR+I N+K DT + +ERNILE + HPFLVKL++AFQ +L++VL Y +GGELF LER+ TL E++A FY+AE +LA+GHLH G+IYRDLK ENV+LD+ GHVKLTDFGLSKE LT++FCGT+EYMAPEIL+R GHG VDWWS+G LL+DML G PF ++ + I K+ ++ + P++ + L++ LL +NPK RL G + DVE+IK H FF++ INW R + PPF PEL S DVS FD + +++P + ++ F+ FSYV+P V L+E + + TR + S + + + FL E DF+++
Sbjct: 42 KREEDDDIESVEICQSVVNP-GVKISMEDFKVLNVIGRGGYGKVFLVQKSSSGHDENKLYAMKVLKKARIIRNEK-DTAHTKSERNILEMIRHPFLVKLHYAFQNQSNLYIVLTYCSGGELFTYLEREGTLMENQACFYVAEISLAIGHLHKTGIIYRDLKPENVLLDKKGHVKLTDFGLSKE--SVSLTNTFCGTIEYMAPEILKRGGHGKEVDWWSLGTLLFDMLSGGPPFSQECDKQETITKILHSTIAYPKYFSSEVVRLIQGLLKRNPKERL-GCKNDVEDIKNHEFFKTHDINWSDVYHRRMDPPFKPELKSEMDVSCFDSTFTGQQPIMTPDDCNGAHILPDLFQGFSYVAPNVASSVLNEPMTGVSRHTRRRNNSGLSGNAFNGLNANSPFLNENDFIEM 444
BLAST of Ribosomal protein S6 kinase vs. Planmine SMEST
Match: SMESG000059433.1 (SMESG000059433.1) HSP 1 Score: 314.309 bits (804), Expect = 2.087e-98 Identity = 174/379 (45.91%), Postives = 244/379 (64.38%), Query Frame = 1
Query: 127 INGIELEANDSDNLNKDEYDSTS-KSVDICEETVNPPGVKVTSHDFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER--NDD-ELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSE-----PCMISPTTTDDSNCYWFENFSYVSPQV 1236
+N +E++ SDN E ++T +VD+ +E K+ S F+LL+ LG+G +G+VFL +KV+ G +AMKV+KKA L K D K ER+IL A+ HPF+V L++AFQ ++L+LE+L GG+LF +L ++ TED+ +FYLAE LAL HLHS+G++YRDLK EN++LD GH+KLTDFGLSKE NDD T SFCGTVEYMAPE++ R+GHG + DWWS G+L+++ML G PF G +R + + + AKL +P+FL+ + LL+ L +NP R+G G K +EEIK FF+ INW L R++ PPF P+ + DD S FD S+ PC + T ++ F FSYV+P V
Sbjct: 15 LNEVEVDEEFSDNAFSQEEEATEVNAVDLVDE-------KLDSSHFELLRVLGQGSFGKVFLVRKVSEPQQGILYAMKVLKKASL---KVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYLAELALALDHLHSLGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPFQGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQLINWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANE----IFRGFSYVAPDV 379 HSP 2 Score: 101.679 bits (252), Expect = 2.103e-22 Identity = 55/163 (33.74%), Postives = 96/163 (58.90%), Query Frame = 1
Query: 415 TERNILEAVN-------HPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYG----HVKLTDFGLSK-ERNDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPF 867
T+R+++E V HP +VKL + +++ L++EYL GGEL + Q +E EA L T + +LH+ V++RDLK N++ + ++ + DFG +K +R ++ L + C T ++APE+L+++G+ + D WS+G+LL+ ML G +PF
Sbjct: 445 TKRDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPF 607
BLAST of Ribosomal protein S6 kinase vs. Planmine SMEST
Match: SMESG000022857.1 (SMESG000022857.1) HSP 1 Score: 240.35 bits (612), Expect = 6.507e-73 Identity = 145/344 (42.15%), Postives = 212/344 (61.63%), Query Frame = 1
Query: 256 DFDXXXXXXXXXYGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNIL-EAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKERNDDE-LTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKI----PRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEP-------------CMISPTTTDDSNCYWFENFSYVSP 1230
DFD +K +GKG +G+VFLA++ + G FA+KV+ K + K+N+ K+ M+ERNIL + + HPFL +LYF+FQT L+ L+Y+ GGELF L+++ + ++ A+FY AE +LG+LHS +IYRDLK EN++LD GH+ LTDFGL KE + E T +FCGT EY+APE++++ + SVDWWS G ++Y+ML G PF + Q+ Q++ N+ L + P ++D +L L+ KNPK RL G + D +EIK H FF I+W + +++KPPF+P++SS D+ D EP +S DDS F FSYV P
Sbjct: 142 DFDFIKTIGKGSFGKVFLARRKSD---GAVFAVKVLYKENI--KKRNEVKHIMSERNILVQNLRHPFLCRLYFSFQTKRKLYFFLDYVNGGELFFHLQKERSFSQKRAQFYAAEIGSSLGYLHSKNIIYRDLKPENILLDAQGHIILTDFGLCKEGIEREGTTSTFCGTPEYLAPEVIKKEPYDRSVDWWSFGSVIYEMLFGLPPFYSQDTHQMYQRILNSPLPLRGNCPSVISD----ILVKLIRKNPKERL-GYKNDFDEIKVHPFFSQIDWVALVNKQVKPPFVPQVSSNADIRNIDPEFHKEPISGSIPNSQLNRRTQLSVEDVDDS----FVGFSYVPP 471
BLAST of Ribosomal protein S6 kinase vs. Planmine SMEST
Match: SMESG000077752.1 (SMESG000077752.1) HSP 1 Score: 225.328 bits (573), Expect = 1.543e-68 Identity = 117/308 (37.99%), Postives = 187/308 (60.71%), Query Frame = 1
Query: 292 YGQVFLAKKVNGAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKERNDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQVIQKVTNAKLKIPRFLTDSGXXXXXXXXXXXXXARLGGGEKDVEEIKRHFFFRSINWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISPTTTDDSNCYWFENF 1215
+G+V + ++ G Y+A+K++ ++ K+ ++ ++E+ ILE ++HPF+V LY+ L+++LEY GGELF L + A FY AE A+ +LH + ++YRDLK EN++LD+ GH+K+TDFG +K D T++ CGT EY+APEI+Q +G+ +VDWW++GIL+Y+ML GN PF N Q+ QK+ N+K + P+ + K L+K LL + RLG + E++ RH +F+SI+W++ L R+++PP IP ++ D +D + ISP TT F NF
Sbjct: 59 FGRVMVVREKE---TGSYYALKIMIIEDILKMKQ--VEHVLSEKQILEQISHPFIVDLYWTKSDIKFLYMLLEYACGGELFTYLRNMAKFPDSTAMFYSAEIVSAISYLHGLRIVYRDLKPENLLLDQKGHIKITDFGFAKFLTDR--TYTMCGTPEYLAPEIIQGKGYNKAVDWWALGILIYEMLSGNPPFSDDNPMQIYQKILNSKFEFPKQIDSIAKDLIKKLLISDRMRRLGNMKGGSEDVMRHRWFKSIDWNELLKRKIEPPIIPNITHVGDTRCYDNYDEQDWRKISPATTKSQEI--FRNF 357 The following BLAST results are available for this feature:
BLAST of Ribosomal protein S6 kinase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Ribosomal protein S6 kinase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Ribosomal protein S6 kinase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Ribosomal protein S6 kinase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Ribosomal protein S6 kinase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Ribosomal protein S6 kinase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Ribosomal protein S6 kinase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Ribosomal protein S6 kinase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Ribosomal protein S6 kinase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Ribosomal protein S6 kinase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Ribosomal protein S6 kinase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Ribosomal protein S6 kinase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Ribosomal protein S6 kinase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Ribosomal protein S6 kinase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30031106 ID=SMED30031106|Name=Ribosomal protein S6 kinase|organism=Schmidtea mediterranea sexual|type=transcript|length=1617bpback to top protein sequence of SMED30031106-orf-1 >SMED30031106-orf-1 ID=SMED30031106-orf-1|Name=SMED30031106-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=442bp MAIVNASSIEGLKIFKDLKLKCDLINGIELEANDSDNLNKDEYDSTSKSVback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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