activin 1

Overview
Nameactivin 1 (AGX01005.1)
Smed IDSMED30031091
Length (bp)1782
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of activin 1 (SMED30031091) t-SNE clustered cells

Violin plots show distribution of expression levels for activin 1 (SMED30031091) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of activin 1 (SMED30031091) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for activin 1 (SMED30031091) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30031091

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 12

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
gutSMED30031091SMESG000072407.1 Contig4428GPL15192PMID:23079596
Forsthoefel et al., 2012		whole organism asexual adult colorimetric in situ hybridization evidence
intestinal phagocyteSMED30031091SMESG000072407.1 Contig4428GPL15192PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
gutSMED30031091SMESG000024833.1 Contig4428GPL15192PMID:23079596
Forsthoefel et al., 2012		whole organism asexual adult colorimetric in situ hybridization evidence
intestinal phagocyteSMED30031091SMESG000024833.1 Contig4428GPL15192PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
nervous systemSMED30031091SMESG000024833.1 SMESG000024831.1 dd_Smed_v4_4120_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30031091SMESG000024833.1 SMESG000024831.1 dd_Smed_v4_4120_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30031091SMESG000024833.1 SMESG000024831.1 dd_Smed_v4_4120_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30031091SMESG000024833.1 SMESG000024831.1 dd_Smed_v4_4120_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30031091SMESG000024833.1 SMESG000024831.1 SMESG000041900.1 SMESG000031061.1 Contig45752newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30031091SMESG000024833.1 SMESG000024831.1 SMESG000041900.1 SMESG000031061.1 Contig45752uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
head regionSMED30031091SMESG000024833.1 SMESG000024831.1 OX_Smed_1.0.01410ox_Smed_v2PMID:24238224
Kao et al., 2013		whole organism asexual adult RNA-sequencing evidence
nervous systemSMED30031091SMESG000024833.1 SMESG000024831.1 dd_Smed_v4_4120_0_1dd_Smed_v4PMID:30962434
Cote et al., 2019		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of activin 1 vs. Ensembl Human
Match: INHBE (inhibin subunit beta E [Source:HGNC Symbol;Acc:HGNC:24029])

HSP 1 Score: 68.5514 bits (166), Expect = 7.431e-12
Identity = 44/154 (28.57%), Postives = 71/154 (46.10%), Query Frame = 2 
Query:  767 GFQKPNVYIRTIILLASMASAKRRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQNLI-SPDLIHLNYCKGDCNHY---SP--YRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGCN 1210
            G Q+P + ++          A+RR P          C  ++  CC ++  V   +LG ++ I  P+   LNYC G C  +   SP    S H++  S+LK +     S        +CC P     L + Y D+  ++  T+V DM+VE+CGC+
Sbjct:  213 GHQQPFLELKIRANEPGAGRARRRTP---------TCEPATPLCCRRDHYVDFQELGWRDWILQPEGYQLNYCSGQCPPHLAGSPGIAASFHSAVFSLLKANNPWPAST-------SCCVPTARRPLSLLYLDHNGNVVKTDVPDMVVEACGCS 350
[Close]
BLAST of activin 1 vs. Ensembl Human
Match: INHBA (inhibin subunit beta A [Source:HGNC Symbol;Acc:HGNC:6066])

HSP 1 Score: 63.929 bits (154), Expect = 3.189e-10
Identity = 39/141 (27.66%), Postives = 67/141 (47.52%), Query Frame = 2 
Query:  794 RTIILLASMASAKRRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQN-LISPDLIHLNYCKGDC-NHYSPYRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGCN 1210
            R  ++L +  S    + R   ++  L C      CC K F V+  D+G  + +I+P   H NYC+G+C +H +       S+ S +  +   +        +K+CC P     + + Y D  Q+I   ++ +MIVE CGC+
Sbjct:  290 RPFLMLQARQSEDHPHRR---RRRGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVI-NHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS 426
[Close]
BLAST of activin 1 vs. Ensembl Human
Match: INHBA (inhibin subunit beta A [Source:HGNC Symbol;Acc:HGNC:6066])

HSP 1 Score: 63.929 bits (154), Expect = 3.189e-10
Identity = 39/141 (27.66%), Postives = 67/141 (47.52%), Query Frame = 2 
Query:  794 RTIILLASMASAKRRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQN-LISPDLIHLNYCKGDC-NHYSPYRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGCN 1210
            R  ++L +  S    + R   ++  L C      CC K F V+  D+G  + +I+P   H NYC+G+C +H +       S+ S +  +   +        +K+CC P     + + Y D  Q+I   ++ +MIVE CGC+
Sbjct:  290 RPFLMLQARQSEDHPHRR---RRRGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVI-NHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS 426
[Close]
BLAST of activin 1 vs. Ensembl Human
Match: INHBA (inhibin subunit beta A [Source:HGNC Symbol;Acc:HGNC:6066])

HSP 1 Score: 63.929 bits (154), Expect = 3.189e-10
Identity = 39/141 (27.66%), Postives = 67/141 (47.52%), Query Frame = 2 
Query:  794 RTIILLASMASAKRRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQN-LISPDLIHLNYCKGDC-NHYSPYRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGCN 1210
            R  ++L +  S    + R   ++  L C      CC K F V+  D+G  + +I+P   H NYC+G+C +H +       S+ S +  +   +        +K+CC P     + + Y D  Q+I   ++ +MIVE CGC+
Sbjct:  290 RPFLMLQARQSEDHPHRR---RRRGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVI-NHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS 426
[Close]
BLAST of activin 1 vs. Ensembl Human
Match: INHBC (inhibin subunit beta C [Source:HGNC Symbol;Acc:HGNC:6068])

HSP 1 Score: 59.6918 bits (143), Expect = 7.068e-9
Identity = 56/224 (25.00%), Postives = 90/224 (40.18%), Query Frame = 2 
Query:  620 TFNIKSRQLQVGIH------------EIECTNILQLFFSKYNQ---TDGKKILKLGLRVQYN------GKGFQKPNVYIRTIILLASMASAKRRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQN-LISPDLIHLNYCKGDCN-HYSPY----RSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGCN 1210
            T+ +K R L +G H            E++ +   QL      Q   + G   L+L L  Q        G    +P V  R  +        K +  R  +      C   S  CC + F V   ++G  + +I P+   +N+C G C  H +       S H + L++LK +     +A       +CC P     L + Y D   +I  T++ DM+VE+CGC+
Sbjct:  145 TWTLKVRVLVLGPHNTNLTLATQYLLEVDASGWHQLPLGPEAQAACSQGHLTLELVLEGQVAQSSVILGGAAHRPFVAARVRV------GGKHQIHRRGID-----CQGGSRMCCRQEFFVDFREIGWHDWIIQPEGYAMNFCIGQCPLHIAGMPGIAASFHTAVLNLLKAN-----TAAGTTGGGSCCVPTARRPLSLLYYDRDSNIVKTDIPDMVVEACGCS 352
[Close]
BLAST of activin 1 vs. Ensembl Fly
Match: daw (gene:FBgn0031461 transcript:FBtr0335151)

HSP 1 Score: 50.447 bits (119), Expect = 4.036e-6
Identity = 31/112 (27.68%), Postives = 55/112 (49.11%), Query Frame = 2 
Query:  875 CTSSSIFCCMKNFTVTPTDLGLQNLI-SPDLIHLNYCKGDCNHYSPYRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGC 1207
            C+S    CC ++  ++  D+G  N I  P+  +  +C+G C+  +      + + S++K   TS   A +   +  CCT   Y+ LQ+   D +       + +M+VESCGC
Sbjct:  476 CSSGMTECCREHLYISFRDIGWSNWILKPEGYNAYFCRGSCSSVASVTQAASHHSSIMKILSTS--GANKSLELVPCCTAKQYSSLQLVVMDSSNTATVKTLPNMVVESCGC 585
[Close]
BLAST of activin 1 vs. Ensembl Fly
Match: daw (gene:FBgn0031461 transcript:FBtr0077720)

HSP 1 Score: 50.447 bits (119), Expect = 4.036e-6
Identity = 31/112 (27.68%), Postives = 55/112 (49.11%), Query Frame = 2 
Query:  875 CTSSSIFCCMKNFTVTPTDLGLQNLI-SPDLIHLNYCKGDCNHYSPYRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGC 1207
            C+S    CC ++  ++  D+G  N I  P+  +  +C+G C+  +      + + S++K   TS   A +   +  CCT   Y+ LQ+   D +       + +M+VESCGC
Sbjct:  476 CSSGMTECCREHLYISFRDIGWSNWILKPEGYNAYFCRGSCSSVASVTQAASHHSSIMKILSTS--GANKSLELVPCCTAKQYSSLQLVVMDSSNTATVKTLPNMVVESCGC 585
[Close]
BLAST of activin 1 vs. Ensembl Fly
Match: daw (gene:FBgn0031461 transcript:FBtr0077721)

HSP 1 Score: 50.447 bits (119), Expect = 4.036e-6
Identity = 31/112 (27.68%), Postives = 55/112 (49.11%), Query Frame = 2 
Query:  875 CTSSSIFCCMKNFTVTPTDLGLQNLI-SPDLIHLNYCKGDCNHYSPYRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGC 1207
            C+S    CC ++  ++  D+G  N I  P+  +  +C+G C+  +      + + S++K   TS   A +   +  CCT   Y+ LQ+   D +       + +M+VESCGC
Sbjct:  476 CSSGMTECCREHLYISFRDIGWSNWILKPEGYNAYFCRGSCSSVASVTQAASHHSSIMKILSTS--GANKSLELVPCCTAKQYSSLQLVVMDSSNTATVKTLPNMVVESCGC 585
[Close]
BLAST of activin 1 vs. Ensembl Zebrafish
Match: CABZ01117503.1 (inhibin beta B chain-like [Source:NCBI gene;Acc:100329520])

HSP 1 Score: 76.6406 bits (187), Expect = 1.461e-14
Identity = 56/193 (29.02%), Postives = 87/193 (45.08%), Query Frame = 2 
Query:  653 GIHEIECTNILQLFFSKYNQTDGKKILKLGLRVQYNGKGF--QKPNVYIRTIILLASMASAKRRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQN-LISPDLIHLNYCKGDCNHY---SP--YRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGC 1207
            G H    T+ LQ F        G++ L+L ++ Q  G+    ++P         L +    +    + A+ +  L C      CC K+F +   D+  Q+ +I+P+  H+NYC G C  +   SP    S HAS  S LK +  +         + +CC P+    L + Y +    I  T+V DMIVESCGC
Sbjct:  198 GWHTFPVTSTLQAFLDG-----GQRRLRLEVQCQDAGRNLCKKEPTEDSSHQPFLVAQVRLREDPSKHALSKRSLRCGDDVTVCCKKDFYIKFRDIQWQDWIIAPEGYHMNYCMGQCPQHLSGSPGIASSFHASVFSQLKANGINT-------AVSSCCVPIQRRPLSMVYFNSQHTIVKTDVPDMIVESCGC 378
[Close]
BLAST of activin 1 vs. Ensembl Zebrafish
Match: inhbaa (inhibin subunit beta Aa [Source:ZFIN;Acc:ZDB-GENE-000210-21])

HSP 1 Score: 61.6178 bits (148), Expect = 1.248e-9
Identity = 34/116 (29.31%), Postives = 56/116 (48.28%), Query Frame = 2 
Query:  869 LVCTSSSIFCCMKNFTVTPTDLGLQN-LISPDLIHLNYCKGDC-NHYSPYRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGCN 1210
            L C   +  CC + F V   D+G  + +I+P   H NYC+GDC ++ +       S+ S +  S   +        +K+CC P     + + Y +  Q I   ++ +MIVE CGC+
Sbjct:  281 LECDGKARVCCKRQFYVNFKDIGWNDWIIAPSGYHANYCEGDCASNVASITGNSLSFHSTVI-SHYRIRGYSPFTNIKSCCVPTRLRAMSMLYYNEEQKIVKKDIQNMIVEECGCS 395
[Close]
BLAST of activin 1 vs. Ensembl Zebrafish
Match: inhbab (inhibin subunit beta Ab [Source:ZFIN;Acc:ZDB-GENE-050525-2])

HSP 1 Score: 58.5362 bits (140), Expect = 1.010e-8
Identity = 37/139 (26.62%), Postives = 62/139 (44.60%), Query Frame = 2 
Query:  800 IILLASMASAKRRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQN-LISPDLIHLNYCKGDC-NHYSPYRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGCN 1210
            ++L  +     RR  R       L C      CC + F V   D+G  + +I+P   H NYC+GDC +H +       S+ S +  +   +        +K+CC P     + + Y +  Q I   ++ +MIV+ CGC+
Sbjct:  274 VVLKPAEEHQHRRSKRG------LECDGKIRVCCKRQFYVNFKDIGWSDWIIAPSGYHANYCEGDCPSHVASITGSALSFHSTVI-NHYRMRGYSPFNNIKSCCVPTRLRAMSMLYYNEEQKIIKKDIQNMIVDECGCS 405
[Close]
BLAST of activin 1 vs. Ensembl Zebrafish
Match: inhbab (inhibin subunit beta Ab [Source:ZFIN;Acc:ZDB-GENE-050525-2])

HSP 1 Score: 58.5362 bits (140), Expect = 1.010e-8
Identity = 37/139 (26.62%), Postives = 62/139 (44.60%), Query Frame = 2 
Query:  800 IILLASMASAKRRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQN-LISPDLIHLNYCKGDC-NHYSPYRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGCN 1210
            ++L  +     RR  R       L C      CC + F V   D+G  + +I+P   H NYC+GDC +H +       S+ S +  +   +        +K+CC P     + + Y +  Q I   ++ +MIV+ CGC+
Sbjct:  274 VVLKPAEEHQHRRSKRG------LECDGKIRVCCKRQFYVNFKDIGWSDWIIAPSGYHANYCEGDCPSHVASITGSALSFHSTVI-NHYRMRGYSPFNNIKSCCVPTRLRAMSMLYYNEEQKIIKKDIQNMIVDECGCS 405
[Close]
BLAST of activin 1 vs. Ensembl Zebrafish
Match: CABZ01074203.1 (inhibin beta B chain-like [Source:NCBI gene;Acc:100332902])

HSP 1 Score: 56.9954 bits (136), Expect = 1.457e-8
Identity = 51/197 (25.89%), Postives = 89/197 (45.18%), Query Frame = 2 
Query:  653 GIHEIECTNILQLFFSKYNQTDGKKILKLGLRVQYNGKGFQKPNVYIRTIILLASMASAKRRY----PRAA-----VKQSPLVCTSSSIFCCMKNFTVTPTDLGLQN-LISPDLIHLNYCKGDCNHYSPYRSKHAS--YLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGC 1207
            G H    T+ +Q+ FS+     G +   L +R +    G +K  V     IL+ S   + R +     R A     +++  L C  S+  CC + F +    +G  + +I+P     NYC+G+C  Y       AS  + +++ + +   +S     +M +CC P   + + + Y D   +I   +V +MIVE CGC
Sbjct:   82 GWHTFPLTDAVQMVFSQ-----GDRRQNLDVRCE----GCEKMGV---VPILVNSADESHRPFLVVQARVADNKHRIRKRGLECDGSNSLCCRQQFYIDFRLIGWNDWIIAPSGYFGNYCEGNCPAYMAGVPGSASSFHTAVVNQYRMRGMSP---GSMNSCCIPTKLSTMSMLYFDDEYNIVKRDVPNMIVEECGC 263
[Close]
BLAST of activin 1 vs. Ensembl Xenopus
Match: INHBA (inhibin subunit beta A [Source:NCBI gene;Acc:100038114])

HSP 1 Score: 70.0922 bits (170), Expect = 3.377e-12
Identity = 38/120 (31.67%), Postives = 63/120 (52.50%), Query Frame = 2 
Query:  857 KQSPLVCTSSSIFCCMKNFTVTPTDLGLQN-LISPDLIHLNYCKGDC-NHYSPYRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGCN 1210
            K+  L C      CC K+F V+  D+G  + +I+P   H NYC+GDC +H++       S+ S +  ++  L       ++K+CC P     + + Y D  Q+I   ++ +MIVE CGC+
Sbjct:  293 KKRGLECDGKVSICCKKHFYVSFKDIGWNDWIIAPPGYHANYCEGDCPSHFAGTTGSSLSFHSTVI-NQYRLRGQSPFTSIKSCCVPSKLRAMSMLYYDDGQNIIKKDIQNMIVEECGCS 411
[Close]
BLAST of activin 1 vs. Ensembl Xenopus
Match: INHBC (inhibin subunit beta C [Source:HGNC Symbol;Acc:HGNC:6068])

HSP 1 Score: 65.4698 bits (158), Expect = 6.866e-11
Identity = 38/117 (32.48%), Postives = 58/117 (49.57%), Query Frame = 2 
Query:  875 CTSSSIFCCMKNFTVTPTDLGLQN-LISPDLIHLNYCKGDCNHY-----SPYRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGC 1207
            C+S    CC KNF +   ++G  + +ISP+  ++NYC+G C  +         S H + LS++K +           +  +CC P     L + Y D    I  T++ DMIVESCGC
Sbjct:  230 CSSDVDMCCRKNFYIDFKEIGWTDWIISPEGYNMNYCEGRCPVHLARVPGIAASSHTAILSLIKANNL-------YASFSSCCVPTKRRPLSLLYFDMYNSIVKTDIPDMIVESCGC 339
[Close]
BLAST of activin 1 vs. Ensembl Xenopus
Match: piwil4 (piwi-like RNA-mediated gene silencing 4 [Source:Xenbase;Acc:XB-GENE-993661])

HSP 1 Score: 63.5438 bits (153), Expect = 3.668e-10
Identity = 55/195 (28.21%), Postives = 89/195 (45.64%), Query Frame = 2 
Query:  650 VGIHEIECTNILQLFFSKYNQTDGKKILKLGLRVQYNGKGFQKPNVYI-----RTIILLASMASAKRRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQN-LISPDLIHLNYCKGDCN-HYSPYRSKHASYLSMLKRSKTSLLSARQLETMKN-CCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGCN 1210
             G       + LQ FF   N++         L+++ N +G Q   V I         L+A     ++ +   A K+S L C  +S  CC K++ V   D+G  + +I P+   +NYC G C  H +      AS+ + +     +L+ A  ++   N CC P     L + Y D   +I  T++ DMIVE+CGC+
Sbjct:  189 TGWQTFSLKSTLQAFFDGGNKS---------LQLELNCEGCQDAPVLINLNDSHQPFLVAQAKVHEQSH--HATKRS-LNCDQNSNLCCRKDYYVDFKDIGWNDWIIKPEGYQINYCMGLCPMHIAGAPGMAASFHTTV----FNLIKANNIQNAVNSCCVPTKRRPLSMLYFDRNNNILKTDIADMIVEACGCS 367
[Close]
BLAST of activin 1 vs. Ensembl Xenopus
Match: INHBB (inhibin subunit beta B [Source:NCBI gene;Acc:100124901])

HSP 1 Score: 53.5286 bits (127), Expect = 4.238e-8
Identity = 39/145 (26.90%), Postives = 67/145 (46.21%), Query Frame = 2 
Query:  803 ILLASMASAKRRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQN-LISPDLIHLNYCKGDCNHYSPYRSKHASYLSMLKRSKTSLLSA-------RQLE--TMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGC 1207
            ++ A +A  K R     +++  L C   +  CC + F +    +G  + +I+P   + NYC+G C           +YL+ +  S +S  +A       R L   T+ +CC P   + + + Y D   +I   +V +MIVE CGC
Sbjct:    1 VVHARLADNKHR-----IRKRGLECDGRTNLCCRQQFYIDFRLIGWNDWIIAPAGYYGNYCEGSC----------PAYLAGVPGSASSFHTAVVNQYRMRGLNPGTVNSCCIPTKLSTMSMLYFDDEYNIVKRDVPNMIVEECGC 130
[Close]
BLAST of activin 1 vs. Ensembl Xenopus
Match: atrip (ATR interacting protein [Source:Xenbase;Acc:XB-GENE-493757])

HSP 1 Score: 51.2174 bits (121), Expect = 3.314e-6
Identity = 79/400 (19.75%), Postives = 151/400 (37.75%), Query Frame = 2 
Query:  155 LSLFFIKVSILFLLFERMRGETFHDLDQLKRKLAITQFRNK------LIDHFKKFKIESVLTGV------SHHEGTKTKNINRILAGIEKIQEI------------------PSENRKTVTKILVLGVKANSCVR--PSTACIEF-LLPQKFFNENIKLAKFLLAVPGRRGVLIRWQIDLIIGRMQIATFNIKSRQLQVGIHE-------IECTNILQLFFSKYNQTDGKKILKLG-----LRVQYNGKGFQKPNVYIRTIILLASMASAKRRYPRAAVKQSPLVCT--SSSIFCCMKNFTVTPTDLGLQNLISPDLIHLNYCKGDCNHYSPYRSKHASYLSMLKRSKTSLLS-ARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGCN 1210
            L   F+ + +L + F + +GE       L+ +L + +   +         H K+ ++ES+ + +              + +N++L     +Q+I                    E   T   ++ +  + +  VR   +  C  F   P+  F + +K   ++   P +    +  QI  +    +  + +I+ R L++ +H        I+  ++LQ +F + +   G +I         L V   G G +     +   + L  M + KR     + +   L C   S+   CC    TV     G   +I+P     NYC G C            Y+ M K   T L+  A    +   CCTP   + + + Y +  Q I   ++  M+V+ CGC+
Sbjct:   46 LCPLFLCMLVLSMEFSKSKGEAIQQKGSLQVELTLGESEEQDCPVCTWRKHSKEMRLESIKSQILSKLRLKEAPNISREVVNQLLPKAPPLQQILDQHEFQGDSFQHNTFLEEDEYHATTETVISMAQETDHAVRIDGNPHCCYFNFSPKIMFTKVVKAQLWVYLRPVQHTSTVYLQILRLKPVTEEGSKHIRIRSLKIDLHSRSGHWQSIDFKHVLQNWFKQPHNNWGIEINAFDPNGNDLAVTSLGPGAEG----LHPFMELRVMENNKR-----SRRNLGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGQC-----------EYMFMQKYPHTHLVQQANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS 425
[Close]
BLAST of activin 1 vs. Ensembl Mouse
Match: Inhbe (inhibin beta-E [Source:MGI Symbol;Acc:MGI:109269])

HSP 1 Score: 68.5514 bits (166), Expect = 4.965e-12
Identity = 44/161 (27.33%), Postives = 72/161 (44.72%), Query Frame = 2 
Query:  746 RVQYNGKGFQKPNVYIRTIILLASMASAKRRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQNLI-SPDLIHLNYCKGDCNHY---SP--YRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGCN 1210
            R+  +  G Q+P + ++          A+RR P          C   +  CC ++  V   +LG ++ I  P+   LNYC G C  +   SP    S H++  S+LK +              +CC P     L + Y D+  ++  T+V DM+VE+CGC+
Sbjct:  206 RLLLDTAGQQRPFLELKIRANEPGAGRARRRTP---------TCEPETPLCCRRDHYVDFQELGWRDWILQPEGYQLNYCSGQCPPHLAGSPGIAASFHSAVFSLLKANNP-------WPAGSSCCVPTARRPLSLLYLDHNGNVVKTDVPDMVVEACGCS 350
[Close]
BLAST of activin 1 vs. Ensembl Mouse
Match: Inhba (inhibin beta-A [Source:MGI Symbol;Acc:MGI:96570])

HSP 1 Score: 64.6994 bits (156), Expect = 1.569e-10
Identity = 39/141 (27.66%), Postives = 67/141 (47.52%), Query Frame = 2 
Query:  794 RTIILLASMASAKRRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQN-LISPDLIHLNYCKGDC-NHYSPYRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGCN 1210
            R  ++L +  S    + R   ++  L C      CC K F V+  D+G  + +I+P   H NYC+G+C +H +       S+ S +  +   +        +K+CC P     + + Y D  Q+I   ++ +MIVE CGC+
Sbjct:  288 RPFLMLQARQSEDHPHRR---RRRGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVI-NHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS 424
[Close]
BLAST of activin 1 vs. Ensembl Mouse
Match: Inhba (inhibin beta-A [Source:MGI Symbol;Acc:MGI:96570])

HSP 1 Score: 64.6994 bits (156), Expect = 1.569e-10
Identity = 39/141 (27.66%), Postives = 67/141 (47.52%), Query Frame = 2 
Query:  794 RTIILLASMASAKRRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQN-LISPDLIHLNYCKGDC-NHYSPYRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGCN 1210
            R  ++L +  S    + R   ++  L C      CC K F V+  D+G  + +I+P   H NYC+G+C +H +       S+ S +  +   +        +K+CC P     + + Y D  Q+I   ++ +MIVE CGC+
Sbjct:  288 RPFLMLQARQSEDHPHRR---RRRGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVI-NHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS 424
[Close]
BLAST of activin 1 vs. Ensembl Mouse
Match: Inhbc (inhibin beta-C [Source:MGI Symbol;Acc:MGI:105932])

HSP 1 Score: 62.7734 bits (151), Expect = 4.545e-10
Identity = 35/125 (28.00%), Postives = 62/125 (49.60%), Query Frame = 2 
Query:  854 VKQSPLVCTSSSIFCCMKNFTVTPTDLGLQN-LISPDLIHLNYCKGDCNHYSP-----YRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGCN 1210
            V++  + C  +S  CC + F V   ++G  + +I P+   +N+C G C  +         S H + L++LK +  +  + R      +CC P     L + Y D   +I  T++ DM+VE+CGC+
Sbjct:  233 VRRRGIDCQGASRMCCRQEFFVDFREIGWNDWIIQPEGYAMNFCTGQCPLHVAGMPGISASFHTAVLNLLKANAAAGTTGR-----GSCCVPTSRRPLSLLYYDRDSNIVKTDIPDMVVEACGCS 352
[Close]
BLAST of activin 1 vs. Ensembl Mouse
Match: Inhbb (inhibin beta-B [Source:MGI Symbol;Acc:MGI:96571])

HSP 1 Score: 53.1434 bits (126), Expect = 5.807e-7
Identity = 36/146 (24.66%), Postives = 67/146 (45.89%), Query Frame = 2 
Query:  800 IILLASMASAKRRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQN-LISPDLIHLNYCKGDCNHYSPYRSKHASYLSMLKRSKTSLLSA-------RQLET--MKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGC 1207
            +++ A +  ++ R     +++  L C   +  CC + F +    +G  + +I+P   + NYC+G C           +YL+ +  S +S  +A       R L    + +CC P   + + + Y D   +I   +V +MIVE CGC
Sbjct:  280 VVVQARLGDSRHR-----IRKRGLECDGRTSLCCRQQFFIDFRLIGWNDWIIAPTGYYGNYCEGSC----------PAYLAGVPGSASSFHTAVVNQYRMRGLNPGPVNSCCIPTKLSSMSMLYFDDEYNIVKRDVPNMIVEECGC 410
[Close]
BLAST of activin 1 vs. UniProt/SwissProt
Match: sp|O88959|INHBE_RAT (Inhibin beta E chain OS=Rattus norvegicus OX=10116 GN=Inhbe PE=2 SV=1)

HSP 1 Score: 69.707 bits (169), Expect = 1.527e-11
Identity = 45/161 (27.95%), Postives = 73/161 (45.34%), Query Frame = 2 
Query:  746 RVQYNGKGFQKPNVYIRTIILLASMASAKRRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQNLI-SPDLIHLNYCKGDCNHY---SP--YRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGCN 1210
            R+  +  G Q+P + ++          A+RR P          C S +  CC ++  V   +LG ++ I  P+   LNYC G C  +   SP    S H++  S+LK +              +CC P     L + Y D+  ++  T+V DM+VE+CGC+
Sbjct:  206 RLLLDTAGQQRPFLELKIRANEPGAGRARRRTP---------TCESETPLCCRRDHYVDFQELGWRDWILQPEGYQLNYCSGQCPPHLAGSPGIAASFHSAVFSLLKANNP-------WPAGSSCCVPTARRPLSLLYLDHNGNVVKTDVPDMVVEACGCS 350
[Close]
BLAST of activin 1 vs. UniProt/SwissProt
Match: sp|O08717|INHBE_MOUSE (Inhibin beta E chain OS=Mus musculus OX=10090 GN=Inhbe PE=2 SV=2)

HSP 1 Score: 68.5514 bits (166), Expect = 3.473e-11
Identity = 44/161 (27.33%), Postives = 72/161 (44.72%), Query Frame = 2 
Query:  746 RVQYNGKGFQKPNVYIRTIILLASMASAKRRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQNLI-SPDLIHLNYCKGDCNHY---SP--YRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGCN 1210
            R+  +  G Q+P + ++          A+RR P          C   +  CC ++  V   +LG ++ I  P+   LNYC G C  +   SP    S H++  S+LK +              +CC P     L + Y D+  ++  T+V DM+VE+CGC+
Sbjct:  206 RLLLDTAGQQRPFLELKIRANEPGAGRARRRTP---------TCEPETPLCCRRDHYVDFQELGWRDWILQPEGYQLNYCSGQCPPHLAGSPGIAASFHSAVFSLLKANNP-------WPAGSSCCVPTARRPLSLLYLDHNGNVVKTDVPDMVVEACGCS 350
[Close]
BLAST of activin 1 vs. UniProt/SwissProt
Match: sp|P58166|INHBE_HUMAN (Inhibin beta E chain OS=Homo sapiens OX=9606 GN=INHBE PE=1 SV=1)

HSP 1 Score: 68.5514 bits (166), Expect = 3.568e-11
Identity = 44/154 (28.57%), Postives = 71/154 (46.10%), Query Frame = 2 
Query:  767 GFQKPNVYIRTIILLASMASAKRRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQNLI-SPDLIHLNYCKGDCNHY---SP--YRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGCN 1210
            G Q+P + ++          A+RR P          C  ++  CC ++  V   +LG ++ I  P+   LNYC G C  +   SP    S H++  S+LK +     S        +CC P     L + Y D+  ++  T+V DM+VE+CGC+
Sbjct:  213 GHQQPFLELKIRANEPGAGRARRRTP---------TCEPATPLCCRRDHYVDFQELGWRDWILQPEGYQLNYCSGQCPPHLAGSPGIAASFHSAVFSLLKANNPWPAST-------SCCVPTARRPLSLLYLDHNGNVVKTDVPDMVVEACGCS 350
[Close]
BLAST of activin 1 vs. UniProt/SwissProt
Match: sp|P55102|INHBA_HORSE (Inhibin beta A chain OS=Equus caballus OX=9796 GN=INHBA PE=2 SV=1)

HSP 1 Score: 65.4698 bits (158), Expect = 6.065e-10
Identity = 36/116 (31.03%), Postives = 58/116 (50.00%), Query Frame = 2 
Query:  869 LVCTSSSIFCCMKNFTVTPTDLGLQN-LISPDLIHLNYCKGDC-NHYSPYRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGCN 1210
            L C      CC K F V+  D+G  + +I+P   H NYC+G+C +H +       S+ S +  ++  L        +K+CC P     + + Y D  Q+I   ++ +MIVE CGC+
Sbjct:  312 LECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVI-NQYRLRGHNPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS 426
[Close]
BLAST of activin 1 vs. UniProt/SwissProt
Match: sp|P18331|INHBA_RAT (Inhibin beta A chain OS=Rattus norvegicus OX=10116 GN=Inhba PE=2 SV=1)

HSP 1 Score: 64.6994 bits (156), Expect = 9.875e-10
Identity = 39/141 (27.66%), Postives = 67/141 (47.52%), Query Frame = 2 
Query:  794 RTIILLASMASAKRRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQN-LISPDLIHLNYCKGDC-NHYSPYRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGCN 1210
            R  ++L +  S    + R   ++  L C      CC K F V+  D+G  + +I+P   H NYC+G+C +H +       S+ S +  +   +        +K+CC P     + + Y D  Q+I   ++ +MIVE CGC+
Sbjct:  288 RPFLMLQARQSEDHPHRR---RRRGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVI-NHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS 424
[Close]
BLAST of activin 1 vs. TrEMBL
Match: U3RA98 (Activin 1 OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 694.886 bits (1792), Expect = 0.000e+0
Identity = 335/335 (100.00%), Postives = 335/335 (100.00%), Query Frame = 2 
Query:  206 MRGETFHDLDQLKRKLAITQFRNKLIDHFKKFKIESVLTGVSHHEGTKTKNINRILAGIEKIQEIPSENRKTVTKILVLGVKANSCVRPSTACIEFLLPQKFFNENIKLAKFLLAVPGRRGVLIRWQIDLIIGRMQIATFNIKSRQLQVGIHEIECTNILQLFFSKYNQTDGKKILKLGLRVQYNGKGFQKPNVYIRTIILLASMASAKRRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQNLISPDLIHLNYCKGDCNHYSPYRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGCN 1210
            MRGETFHDLDQLKRKLAITQFRNKLIDHFKKFKIESVLTGVSHHEGTKTKNINRILAGIEKIQEIPSENRKTVTKILVLGVKANSCVRPSTACIEFLLPQKFFNENIKLAKFLLAVPGRRGVLIRWQIDLIIGRMQIATFNIKSRQLQVGIHEIECTNILQLFFSKYNQTDGKKILKLGLRVQYNGKGFQKPNVYIRTIILLASMASAKRRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQNLISPDLIHLNYCKGDCNHYSPYRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGCN
Sbjct:    1 MRGETFHDLDQLKRKLAITQFRNKLIDHFKKFKIESVLTGVSHHEGTKTKNINRILAGIEKIQEIPSENRKTVTKILVLGVKANSCVRPSTACIEFLLPQKFFNENIKLAKFLLAVPGRRGVLIRWQIDLIIGRMQIATFNIKSRQLQVGIHEIECTNILQLFFSKYNQTDGKKILKLGLRVQYNGKGFQKPNVYIRTIILLASMASAKRRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQNLISPDLIHLNYCKGDCNHYSPYRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGCN 335
[Close]
BLAST of activin 1 vs. TrEMBL
Match: T1D136 (Inhibin-1 OS=Dendrocoelum lacteum OX=27895 PE=2 SV=1)

HSP 1 Score: 86.6557 bits (213), Expect = 1.135e-14
Identity = 49/137 (35.77%), Postives = 77/137 (56.20%), Query Frame = 2 
Query:  800 IILLASMASAKRRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQNLISPDLIHLNYCKGDCNHYSPYRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQY-RDYTQDIRNTEVNDMIVESCGC 1207
            ++L   + S ++R   +A K     CT+  I CC ++F   P D+GL  ++SP  I LNYC G+CN  +   S ++  +SM+KRSK   L+ +Q E+MK CC P  Y  + + Y  +     +   +N+MIV+SC C
Sbjct:  211 VVLGPKVISRRKRSLPSANKS----CTNDDIMCCKRSFIFRPIDIGLGWIVSPREIRLNYCMGECNDQTSNIS-YSQVMSMIKRSKNINLTPQQWESMKFCCAPKKYIGIDVIYLTNNNNTFQKLHLNNMIVDSCSC 342
[Close]
BLAST of activin 1 vs. TrEMBL
Match: I1ZI68 (Inhibin-1 OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 80.4925 bits (197), Expect = 1.369e-12
Identity = 38/112 (33.93%), Postives = 65/112 (58.04%), Query Frame = 2 
Query:  875 CTSSSIFCCMKNFTVTPTDLGLQNLISPDLIHLNYCKGDCNHYSPYRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDY-TQDIRNTEVNDMIVESCGC 1207
            CTS  +FCC +NF   P DLG   ++ P+ I LNYC G+CN Y    + +   +S ++R+K   LS  Q+++M++CC P  YN L++ Y    +   +   + ++++ +C C
Sbjct:  243 CTSKGVFCCKRNFKFRPVDLGWNWIVYPEEIVLNYCSGECNQYIS-SNNYGKMISFIRRTKPH-LSPLQVKSMRSCCAPEDYNGLELIYMPIRSNTFQKMYLPNILINNCSC 352
[Close]
BLAST of activin 1 vs. TrEMBL
Match: A0A452I9Q1 (Inhibin subunit beta C OS=Gopherus agassizii OX=38772 GN=INHBC PE=3 SV=1)

HSP 1 Score: 77.7962 bits (190), Expect = 1.048e-11
Identity = 66/239 (27.62%), Postives = 103/239 (43.10%), Query Frame = 2 
Query:  533 AKFLLAVPGRRGVLIRWQIDLIIGRMQIATFNIKSRQLQVGIHEIECTNILQLFFSKYNQTDGKKILKLGLRVQYNGKGFQKPNVYIRTIILLAS-------MASAKRRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQN-LISPDLIHLNYCKGDC-NHYSPY----RSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGCN 1210
            AK LL+ PG            ++GR Q+    +K    Q G   +E    +Q FFSK  Q          L  +   +G  +P       +LL+S       M +  R  PR  + +  + C S+S  CC K F V   ++G ++ +I P+  H+NYC G C  H +       S H + L+++K +              +CC P     L + Y D   ++  T++ DMIVE+CGC 
Sbjct:  154 AKLLLSEPGNAN-------PTLVGRRQL---EVK----QGGWAAVEVRTAVQSFFSKGGQR---------LTAELELEGSPEP------ALLLSSSESHRPFMVAKTRARPRHRLHRRAVECNSNSRTCCRKQFFVDFKEIGWEDWIIQPEGYHMNYCTGPCPTHVASMPGLASSFHTAILNLIKANDVH-------AAFSSCCIPTRRRPLSLLYYDQDSNVIKTDIPDMIVEACGCT 356
[Close]
BLAST of activin 1 vs. TrEMBL
Match: F1QPH9 (Inhibin subunit beta C OS=Danio rerio OX=7955 GN=LOC100329520 PE=3 SV=1)

HSP 1 Score: 76.6406 bits (187), Expect = 3.268e-11
Identity = 56/193 (29.02%), Postives = 87/193 (45.08%), Query Frame = 2 
Query:  653 GIHEIECTNILQLFFSKYNQTDGKKILKLGLRVQYNGKGF--QKPNVYIRTIILLASMASAKRRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQN-LISPDLIHLNYCKGDCNHY---SP--YRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGC 1207
            G H    T+ LQ F        G++ L+L ++ Q  G+    ++P         L +    +    + A+ +  L C      CC K+F +   D+  Q+ +I+P+  H+NYC G C  +   SP    S HAS  S LK +  +         + +CC P+    L + Y +    I  T+V DMIVESCGC
Sbjct:  198 GWHTFPVTSTLQAFLDG-----GQRRLRLEVQCQDAGRNLCKKEPTEDSSHQPFLVAQVRLREDPSKHALSKRSLRCGDDVTVCCKKDFYIKFRDIQWQDWIIAPEGYHMNYCMGQCPQHLSGSPGIASSFHASVFSQLKANGINT-------AVSSCCVPIQRRPLSMVYFNSQHTIVKTDVPDMIVESCGC 378
[Close]
BLAST of activin 1 vs. Ensembl Cavefish
Match: INHBC (inhibin beta B chain-like [Source:NCBI gene;Acc:103021438])

HSP 1 Score: 69.3218 bits (168), Expect = 2.839e-12
Identity = 56/194 (28.87%), Postives = 89/194 (45.88%), Query Frame = 2 
Query:  653 GIHEIECTNILQLFFSKYNQTDGKKILKLGLRVQYNGKGF--QKPNVYIRTIILLASMASAKRRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQN-LISPDLIHLNYCKGDCNHY---SP--YRSKHASYLSMLKRSKTSLLSARQLET-MKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGC 1207
            G H    ++ LQ F        G++ L+L +  +  G+    ++     +   L+A +    R   + A+ +  L C      CC K+F +   D+  Q+ +I+P+  H+NYC G C  +   SP    S HA+  S LK        A  + T + +CC P+    L + Y +    I  T+V DMIVESCGC
Sbjct:  210 GWHTFPVSSTLQAFLDG-----GQRRLRLEVHCEDGGQNLCSRRGADTSQQPFLVAQVR--LRDDSKHALSKRSLHCGDDVSVCCKKDFYIKFKDIQWQDWIIAPEGYHMNYCMGQCPQHLAGSPGIASSFHATVFSQLK--------ANGIHTAVSSCCVPIQRRPLSMVYFNSQHSIVKTDVPDMIVESCGC 388
[Close]
BLAST of activin 1 vs. Ensembl Cavefish
Match: inhbaa (inhibin beta A chain-like [Source:NCBI gene;Acc:103033691])

HSP 1 Score: 63.5438 bits (153), Expect = 2.085e-10
Identity = 40/137 (29.20%), Postives = 65/137 (47.45%), Query Frame = 2 
Query:  806 LLASMASAKRRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQN-LISPDLIHLNYCKGDC-NHYSPYRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGCN 1210
            L+A +  A  + PR   K+  L C      CC + F V   D+G  + +I+P   H NYC+GDC +H +       S+ S +  +   +        +K+CC P     + + Y +  Q I   ++ +MIVE CGC+
Sbjct:  258 LMAVVRQADDQNPRRRRKRG-LECDGKVRVCCKRQFYVNFKDIGWNDWIIAPSGYHANYCEGDCPSHIASITGTSLSFHSTVI-NHYRMRGYSPFTNIKSCCVPTRLRAMSMLYYNEEQKIVKKDIQNMIVEECGCS 392
[Close]
BLAST of activin 1 vs. Ensembl Cavefish
Match: INHBB (inhibin beta B chain-like [Source:NCBI gene;Acc:103029944])

HSP 1 Score: 58.5362 bits (140), Expect = 7.977e-9
Identity = 50/200 (25.00%), Postives = 87/200 (43.50%), Query Frame = 2 
Query:  653 GIHEIECTNILQLFFSKYNQTDGKKILKLGLRVQ------------YNGKGFQKPNVYIRTIILLASMASAKRRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQN-LISPDLIHLNYCKGDCNHYSPYRSKHAS--YLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGC 1207
            G H    T+ +QL FSK     G++   L +R +             +     +P + +R      +M  +K R     +++  L C  SS  CC + F +    +G  + +I+P     NYC+G C  Y       AS  + +++ + +   +S     +M +CC P   + + + Y D   +I   +V +MIVE CGC
Sbjct:  206 GWHTFPLTDAVQLVFSK-----GERRQNLDIRCEGCEAAGVLPALVNSADEAHRPFLVVRA----RAMEDSKHR-----IRKRGLECDGSSSLCCRQQFYIDFRLIGWNDWIIAPSGYFGNYCEGKCPAYMAGVPGSASSFHTAVVNQYRMRGMSP---GSMNSCCIPTKLSTMSMLYFDDEYNIVKRDVPNMIVEECGC 388
[Close]
BLAST of activin 1 vs. Ensembl Cavefish
Match: inhbab (inhibin beta A chain-like [Source:NCBI gene;Acc:103038302])

HSP 1 Score: 58.9214 bits (141), Expect = 8.576e-9
Identity = 34/116 (29.31%), Postives = 55/116 (47.41%), Query Frame = 2 
Query:  869 LVCTSSSIFCCMKNFTVTPTDLGLQN-LISPDLIHLNYCKGDC-NHYSPYRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGCN 1210
            L C      CC + F V   D+G  + +I+P   H NYC+G+C +H S       S+ S +  +   +        +K+CC P     + + Y +  Q I   ++ +MIVE CGC+
Sbjct:  317 LECDGKIRTCCKRQFYVNFKDIGWSDWIIAPSGYHANYCEGECPSHVSSITGSALSFHSTVI-NHYRMRGYSPFTNIKSCCVPTRLRAMSMLYYNEEQKIIKKDIQNMIVEECGCS 431
[Close]
BLAST of activin 1 vs. Ensembl Cavefish
Match: mstnb (myostatin [Source:NCBI gene;Acc:103027626])

HSP 1 Score: 56.225 bits (134), Expect = 5.497e-8
Identity = 57/233 (24.46%), Postives = 97/233 (41.63%), Query Frame = 2 
Query:  524 IKLAKFLLAVPGRRGVLIR-WQIDLIIGRMQIATFNIKSRQLQVGIHEIECTNILQLFFSKYNQTDGKKILKLGLRVQYNGKGFQKPNVYIRTIILLASMASAKRRYPRAAVKQSPLVC--TSSSIFCCMKNFTVTPTDLGLQNLISPDLIHLNYCKGDCNHYSPYRSKHASYLSMLKRSKTSLLS-ARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGCN 1210
            +++++ +    GRR + IR  +ID+  G     + ++K + L V + + E    +++     N  D K           N      P+V      LL  M       P+ + + S L C   SS   CC    TV   D G   +I+P     NYC G+C+           Y+ + K   T L++ A    T   CCTP   + + + Y +  + I   ++  M+V+ CGC+
Sbjct:  232 LQISRLMPVTDGRRQIRIRSLKIDVKAGVTSWQSIDVK-QVLTVWLRQPETNWGIEI-----NAYDAKG----------NDLAVTSPDVGDEG--LLPFMEVKISEGPKRSRRDSGLDCDENSSESRCCRYPLTVDFEDFGWDWIIAPKRYKANYCSGECD-----------YMHLQKYPHTHLVNKANPRGTAGPCCTPTKMSPINMLYFNGKEQIIYGKLPSMVVDRCGCS 435
[Close]
BLAST of activin 1 vs. Ensembl Sea Lamprey
Match: inhbab (inhibin subunit beta Ab [Source:ZFIN;Acc:ZDB-GENE-050525-2])

HSP 1 Score: 57.7658 bits (138), Expect = 2.888e-9
Identity = 40/138 (28.99%), Postives = 65/138 (47.10%), Query Frame = 2 
Query:  806 LLASMASAK--RRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQN-LISPDLIHLNYCKGDCNHYSPYR-SKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGC 1207
            LL  MAS++   R  R +V+     C  SS  CC++ F V    +   + +I P     NYC+G+C        +  AS L  +  ++ +L     +     CC PV ++ + + Y D   +I+  +V DM+ E CGC
Sbjct:  263 LLLRMASSQGGSRTRRRSVE-----CDGSSSLCCLQRFYVEFRKINWGDWIIQPAGFQSNYCQGECRGAQVLNGTSSASSLRSVIINQYNLRGLGPVAAKTTCCVPVRFSSVSMLYYDDKNNIQKKDVPDMVAEECGC 395
[Close]
BLAST of activin 1 vs. Ensembl Sea Lamprey
Match: inhbb (inhibin subunit beta B [Source:ZFIN;Acc:ZDB-GENE-990415-2])

HSP 1 Score: 55.0694 bits (131), Expect = 2.314e-8
Identity = 38/157 (24.20%), Postives = 60/157 (38.22%), Query Frame = 2 
Query:  740 GLRVQYNGKGFQKPNVYIRTIILLASMASAKRRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQN-LISPDLIHLNYCKGDCNHYSPYRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGC 1207
            G+R     +    P+   R  +LL   +    R     V +  L C   S  CC+  F V    +G  + +I P     N+C G C  Y       ++       ++  L     + +   CC P     + + Y D   +I   +V DM+VE CGC
Sbjct:  205 GVRATLGPRWGDSPDSDYRPFLLLHMGSDMAHR-----VSRRDLQCDDRSDLCCLHRFFVDFHKIGWNDWIIQPSGYQSNFCLGKCPLYMAGTPGASASFHNAIINQYRLRGVEPMASKNPCCVPTRLTSMSMLYLDKQNNIIKKDVPDMVVEECGC 356
[Close]
BLAST of activin 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004249.1 (pep scaffold:Pmarinus_7.0:GL479487:17949:23694:-1 gene:ENSPMAG00000003876.1 transcript:ENSPMAT00000004249.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 48.9062 bits (115), Expect = 2.366e-6
Identity = 47/209 (22.49%), Postives = 78/209 (37.32%), Query Frame = 2 
Query:  599 IGRMQIATFNIKSRQLQVGIHEIECTNILQLFFSKYNQTDGKKILKL---GLRVQYNGKGFQKPNVYIRTIILLASMASAKRRYPRAAVKQSPLVC--TSSSIFCCMKNFTVTPTDLGLQNLISPDLIHLNYCKGDCNHYSPYRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGCN 1210
            +GR+ I ++  +    +     I+   +LQ  F    +  G +I  +   G  +     G Q+  +     + L  +    RR    AV    L C    S   CC  +  V     G   +I+P     NYC G C H    +  H   +     S ++            CC P   + + + Y +  Q I   ++ DM+VE CGC+
Sbjct:  198 VGRIHIRSWKTRLTSPKGHWQRIDSKKLLQNSFKYPERNWGLEIHAVDAEGNELAVTDPGPQEDGLKPFLEVQLMDLQKRSRR----AVG---LDCNDPGSESRCCRYSLVVDFEAFGWDWIIAPKRYKANYCSGQCEHMFLQKYPHTHLVQQANPSGSA----------GPCCAPTKMSAISMLYFNDQQQIIFGKIPDMVVERCGCS 389
[Close]
BLAST of activin 1 vs. Ensembl Nematostella
Match: EDO34888 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SN19])

HSP 1 Score: 51.2174 bits (121), Expect = 4.835e-8
Identity = 34/123 (27.64%), Postives = 55/123 (44.72%), Query Frame = 2 
Query:  845 RAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQNLI-SPDLIHLNYCKGDCNHYSPYRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGCN 1210
            R   K+  + C+     CC + F V+  ++G  N I  P   + NYC G C  +      H   +      K +LL  R+   +  CC P     L + Y D  +++    V++M+VE CGC+
Sbjct:   11 RKQRKKRAIHCSPGMRECCRQEFYVSFEEMGWDNWILVPRGFNANYCTGSCYGHILPVYHHTEVIQ-----KVALL--RKQRELSPCCAPTKMFDLSLLYYDKDENLFQENVSNMVVEECGCS 126
[Close]
BLAST of activin 1 vs. Ensembl Nematostella
Match: MSTN (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RGJ4])

HSP 1 Score: 48.521 bits (114), Expect = 3.714e-6
Identity = 34/123 (27.64%), Postives = 50/123 (40.65%), Query Frame = 2 
Query:  845 RAAVKQSPLVCT--SSSIFCCMKNFTVTPTDLGLQNLISPDLIHLNYCKGDCNHYSPYRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGC 1207
            R A +++ L C   S    CC    TV         +I+P      YC G+C         HA    M+K+S             + CC+P   + + + Y D+ Q I   EV  M+ E+CGC
Sbjct:  214 RRAKRRAGLDCDPYSHERRCCRYELTVDFEKFSWNWIIAPKRFRAYYCTGECQEIMLPMYPHAH---MVKKSTGK----------RPCCSPTKMSSISMIYFDFNQQIMFEEVPAMVAETCGC 323
[Close]
BLAST of activin 1 vs. Ensembl Medaka
Match: INHBC (inhibin beta B chain [Source:NCBI gene;Acc:101163243])

HSP 1 Score: 69.707 bits (169), Expect = 2.172e-12
Identity = 54/195 (27.69%), Postives = 85/195 (43.59%), Query Frame = 2 
Query:  659 HEIECTNILQLFFSKYNQTDGKKILKLGLRVQYNGKGF------QKPNVYIRTIILLASMASAKRRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQN-LISPDLIHLNYCKGDCNHY---SP--YRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGC 1207
            H    T  LQ F        G++ L+L +  + +GK          PN        L +    +  + + +V++  L C +    CC ++F +   D+     +I+P+  H+NYC G C  +   SP    S HA+  S LK +  +  +A       +CC P     L + Y +    I  T+V DMIVESCGC
Sbjct:  201 HTFPITRTLQSFLD-----GGQRRLRLEVSCEEDGKNLCSLDTSDSPNQ-----PFLVAQVRLRDDHSKHSVRKRSLRCGNEVTVCCKRDFYIKFKDIQWDEWIIAPEGYHMNYCMGQCPQHLSGSPGIASSFHATIFSQLKVNGINTATA-------SCCIPTERQPLSMVYFNSQHSIVKTDVPDMIVESCGC 378
[Close]
BLAST of activin 1 vs. Ensembl Medaka
Match: inhbaa (inhibin beta A chain [Source:NCBI gene;Acc:101170230])

HSP 1 Score: 69.707 bits (169), Expect = 3.576e-12
Identity = 44/160 (27.50%), Postives = 74/160 (46.25%), Query Frame = 2 
Query:  749 VQYNGKGFQKPNVYIRTIILLASMASAKRRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQN-LISPDLIHLNYCKGDCNHYS---PYRSK--HASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGCN 1210
            +Q N +  Q    ++  ++       ++RR  R       L C      CC K F V   D+   + +I+P   H NYC+GDC  ++   P  S   H++ +S  +  + S       +++K+CCTP     + + Y D  Q I   ++ +MIVE CGC+
Sbjct:  309 LQRNNQREQSHRPFLMAVVRQGDSNDSRRRRKRG------LECDGKVRVCCKKQFYVNFKDIAWADWIIAPSGYHANYCEGDCPSHAASLPGSSLSFHSTVISHYRMKENS-----PFQSLKSCCTPTKLRAMSMLYYDEKQRIVKKDIPNMIVEECGCS 457
[Close]
BLAST of activin 1 vs. Ensembl Medaka
Match: ENSORLT00000010146.2 (inhibin beta A chain [Source:NCBI gene;Acc:100144359])

HSP 1 Score: 66.2402 bits (160), Expect = 3.666e-11
Identity = 42/139 (30.22%), Postives = 65/139 (46.76%), Query Frame = 2 
Query:  800 IILLASMASAKRRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQN-LISPDLIHLNYCKGDC-NHYSPYRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGCN 1210
            ++L A   +  RR  RA      L C      CC   F V   D+G  + +I+P   H NYC+GDC NH +   S   S+ S +  +   +      + +K+CC P     + + Y +  Q I   ++ +MIVE CGC+
Sbjct:  267 VVLQAREEANPRRVKRA------LECDGKIRLCCKGQFYVNFKDIGWSDWIIAPSGYHANYCEGDCPNHMTNLGSSSLSFHSTVI-NHYRMRGYGPFQNIKSCCVPTKLRAMSMLYYNEEQKIIKKDIQNMIVEECGCS 398
[Close]
BLAST of activin 1 vs. Ensembl Medaka
Match: mstn (myostatin [Source:NCBI gene;Acc:100529165])

HSP 1 Score: 60.077 bits (144), Expect = 2.959e-9
Identity = 65/295 (22.03%), Postives = 115/295 (38.98%), Query Frame = 2 
Query:  380 IEKIQEIPSENRKTVTKILVLGVKANSCVR--PSTACIEFLLPQKFFNENIKLAKFLLAV-PGRRGVLIRWQIDLIIGRMQIATFNIKSRQLQVGIHEIECTNILQLFFSKYNQTDGKKILKLGLRVQYNGKGFQKPNVYIRTIILLASMASAKRRY------------PRAAVKQSPLVCTSSSIF--CCMKNFTVTPTDLGLQNLISPDLIHLNYCKGDCNHYSPYRSKHASYLSMLKRSKTSLLS-ARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGCN 1210
            ++ + E   E+  T T I+++  + +S V+      C  F   QKF+   I  A+  + + P      +  QI  ++         ++ R L++ +         +   S +   D K++L + +R      G +      R   L  + A    +             PR A + S L C  +S    CC    TV   D G   +I+P     NYC G+C            Y+ + K   T L++ A    T   CCTP   + + + Y +  + I   ++  M+V+ CGC+
Sbjct:   95 MDAVAEEDDEHASTET-IMLMATEPDSDVQVDGEPKCCLFSFAQKFYASRIVRAQLWVHLRPADEATTVFLQISRLMPVTDGNRHIVRIRSLKIDV---------RAGLSSWQSIDVKQVLAVWVRQPETNWGIEINAFDSRGNDLAVTSAEPGEQGLQPFIEVKISEGPRRARRDSGLDCDENSPESRCCRYPLTVDFEDFGWDWIIAPKRYKANYCSGEC-----------EYMYLQKYPHTHLVNKANPRGTAGPCCTPTKMSPINMLYFNRKEQIIYGKIPSMVVDRCGCS 368
[Close]
BLAST of activin 1 vs. Ensembl Medaka
Match: INHBB (inhibin subunit beta B [Source:NCBI gene;Acc:101165458])

HSP 1 Score: 60.077 bits (144), Expect = 3.240e-9
Identity = 40/142 (28.17%), Postives = 66/142 (46.48%), Query Frame = 2 
Query:  800 IILLASMASAKRRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQN-LISPDLIHLNYCKGDCNHY-----SPYRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGC 1207
            +++ A  A AK R     +++  L C  SS  CC + F +    +G  + +I+P     NYC+GDC  Y         S H + ++  +    S +S      M +CC P   + + + Y D   +I   +V +MIV+ CGC
Sbjct:  255 LVVRARQADAKHR-----IRKRGLECDGSSDLCCRQQFYIDFRLIGWNDWIIAPSGYFGNYCEGDCPPYMAGVPGSASSFHTAVVNQYRMRGKSPVS------MNSCCIPTKLSTMSMLYFDDEYNIVKRDVPNMIVDECGC 385
[Close]
BLAST of activin 1 vs. Planmine SMEST
Match: SMESG000024833.1 (SMESG000024833.1)

HSP 1 Score: 728.398 bits (1879), Expect = 0.000e+0
Identity = 353/353 (100.00%), Postives = 353/353 (100.00%), Query Frame = 2 
Query:  152 MLSLFFIKVSILFLLFERMRGETFHDLDQLKRKLAITQFRNKLIDHFKKFKIESVLTGVSHHEGTKTKNINRILAGIEKIQEIPSENRKTVTKILVLGVKANSCVRPSTACIEFLLPQKFFNENIKLAKFLLAVPGRRGVLIRWQIDLIIGRMQIATFNIKSRQLQVGIHEIECTNILQLFFSKYNQTDGKKILKLGLRVQYNGKGFQKPNVYIRTIILLASMASAKRRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQNLISPDLIHLNYCKGDCNHYSPYRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGCN 1210
            MLSLFFIKVSILFLLFERMRGETFHDLDQLKRKLAITQFRNKLIDHFKKFKIESVLTGVSHHEGTKTKNINRILAGIEKIQEIPSENRKTVTKILVLGVKANSCVRPSTACIEFLLPQKFFNENIKLAKFLLAVPGRRGVLIRWQIDLIIGRMQIATFNIKSRQLQVGIHEIECTNILQLFFSKYNQTDGKKILKLGLRVQYNGKGFQKPNVYIRTIILLASMASAKRRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQNLISPDLIHLNYCKGDCNHYSPYRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGCN
Sbjct:    1 MLSLFFIKVSILFLLFERMRGETFHDLDQLKRKLAITQFRNKLIDHFKKFKIESVLTGVSHHEGTKTKNINRILAGIEKIQEIPSENRKTVTKILVLGVKANSCVRPSTACIEFLLPQKFFNENIKLAKFLLAVPGRRGVLIRWQIDLIIGRMQIATFNIKSRQLQVGIHEIECTNILQLFFSKYNQTDGKKILKLGLRVQYNGKGFQKPNVYIRTIILLASMASAKRRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQNLISPDLIHLNYCKGDCNHYSPYRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGCN 353
[Close]
BLAST of activin 1 vs. Planmine SMEST
Match: SMESG000024833.1 (SMESG000024833.1)

HSP 1 Score: 694.886 bits (1792), Expect = 0.000e+0
Identity = 335/335 (100.00%), Postives = 335/335 (100.00%), Query Frame = 2 
Query:  206 MRGETFHDLDQLKRKLAITQFRNKLIDHFKKFKIESVLTGVSHHEGTKTKNINRILAGIEKIQEIPSENRKTVTKILVLGVKANSCVRPSTACIEFLLPQKFFNENIKLAKFLLAVPGRRGVLIRWQIDLIIGRMQIATFNIKSRQLQVGIHEIECTNILQLFFSKYNQTDGKKILKLGLRVQYNGKGFQKPNVYIRTIILLASMASAKRRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQNLISPDLIHLNYCKGDCNHYSPYRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGCN 1210
            MRGETFHDLDQLKRKLAITQFRNKLIDHFKKFKIESVLTGVSHHEGTKTKNINRILAGIEKIQEIPSENRKTVTKILVLGVKANSCVRPSTACIEFLLPQKFFNENIKLAKFLLAVPGRRGVLIRWQIDLIIGRMQIATFNIKSRQLQVGIHEIECTNILQLFFSKYNQTDGKKILKLGLRVQYNGKGFQKPNVYIRTIILLASMASAKRRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQNLISPDLIHLNYCKGDCNHYSPYRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGCN
Sbjct:    1 MRGETFHDLDQLKRKLAITQFRNKLIDHFKKFKIESVLTGVSHHEGTKTKNINRILAGIEKIQEIPSENRKTVTKILVLGVKANSCVRPSTACIEFLLPQKFFNENIKLAKFLLAVPGRRGVLIRWQIDLIIGRMQIATFNIKSRQLQVGIHEIECTNILQLFFSKYNQTDGKKILKLGLRVQYNGKGFQKPNVYIRTIILLASMASAKRRYPRAAVKQSPLVCTSSSIFCCMKNFTVTPTDLGLQNLISPDLIHLNYCKGDCNHYSPYRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESCGCN 335
[Close]
BLAST of activin 1 vs. Planmine SMEST
Match: SMESG000024831.1 (SMESG000024831.1)

HSP 1 Score: 174.481 bits (441), Expect = 1.607e-52
Identity = 84/85 (98.82%), Postives = 84/85 (98.82%), Query Frame = 3 
Query: 1428 MALIKTLNLLFVMGTVLVIFTANSNTEEVKRYDTGHDIFRLKKSYHYFRLRRALDQMKCSRNTNDLVNFIEKHCMEKPDFLAQMF 1682
            MALIKTLNLLFVM TVLVIFTANSNTEEVKRYDTGHDIFRLKKSYHYFRLRRALDQMKCSRNTNDLVNFIEKHCMEKPDFLAQMF
Sbjct:    1 MALIKTLNLLFVMCTVLVIFTANSNTEEVKRYDTGHDIFRLKKSYHYFRLRRALDQMKCSRNTNDLVNFIEKHCMEKPDFLAQMF 85
[Close]
BLAST of activin 1 vs. Planmine SMEST
Match: SMESG000024831.1 (SMESG000024831.1)

HSP 1 Score: 151.754 bits (382), Expect = 3.372e-44
Identity = 72/73 (98.63%), Postives = 72/73 (98.63%), Query Frame = 3 
Query: 1464 MGTVLVIFTANSNTEEVKRYDTGHDIFRLKKSYHYFRLRRALDQMKCSRNTNDLVNFIEKHCMEKPDFLAQMF 1682
            M TVLVIFTANSNTEEVKRYDTGHDIFRLKKSYHYFRLRRALDQMKCSRNTNDLVNFIEKHCMEKPDFLAQMF
Sbjct:    1 MCTVLVIFTANSNTEEVKRYDTGHDIFRLKKSYHYFRLRRALDQMKCSRNTNDLVNFIEKHCMEKPDFLAQMF 73
[Close]
BLAST of activin 1 vs. Planmine SMEST
Match: SMESG000062806.1 (SMESG000062806.1)

HSP 1 Score: 80.4925 bits (197), Expect = 3.985e-16
Identity = 38/112 (33.93%), Postives = 65/112 (58.04%), Query Frame = 2 
Query:  875 CTSSSIFCCMKNFTVTPTDLGLQNLISPDLIHLNYCKGDCNHYSPYRSKHASYLSMLKRSKTSLLSARQLETMKNCCTPVFYNKLQIQYRDY-TQDIRNTEVNDMIVESCGC 1207
            CTS  +FCC +NF   P DLG   ++ P+ I LNYC G+CN Y    + +   +S ++R+K   LS  Q+++M++CC P  YN L++ Y    +   +   + ++++ +C C
Sbjct:  243 CTSKGVFCCKRNFKFRPVDLGWNWIVYPEEIVLNYCSGECNQYIS-SNNYGKMISFIRRTKPH-LSPLQVKSMRSCCAPEDYNGLELIYMPIRSNTFQKMYLPNILINNCSC 352
The following BLAST results are available for this feature:
BLAST of activin 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
INHBE7.431e-1228.57inhibin subunit beta E [Source:HGNC Symbol;Acc:HGN... [more]
INHBA3.189e-1027.66inhibin subunit beta A [Source:HGNC Symbol;Acc:HGN... [more]
INHBA3.189e-1027.66inhibin subunit beta A [Source:HGNC Symbol;Acc:HGN... [more]
INHBA3.189e-1027.66inhibin subunit beta A [Source:HGNC Symbol;Acc:HGN... [more]
INHBC7.068e-925.00inhibin subunit beta C [Source:HGNC Symbol;Acc:HGN... [more]
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BLAST of activin 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of activin 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3
Match NameE-valueIdentityDescription
daw4.036e-627.68gene:FBgn0031461 transcript:FBtr0335151[more]
daw4.036e-627.68gene:FBgn0031461 transcript:FBtr0077720[more]
daw4.036e-627.68gene:FBgn0031461 transcript:FBtr0077721[more]
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BLAST of activin 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CABZ01117503.11.461e-1429.02inhibin beta B chain-like [Source:NCBI gene;Acc:10... [more]
inhbaa1.248e-929.31inhibin subunit beta Aa [Source:ZFIN;Acc:ZDB-GENE-... [more]
inhbab1.010e-826.62inhibin subunit beta Ab [Source:ZFIN;Acc:ZDB-GENE-... [more]
inhbab1.010e-826.62inhibin subunit beta Ab [Source:ZFIN;Acc:ZDB-GENE-... [more]
CABZ01074203.11.457e-825.89inhibin beta B chain-like [Source:NCBI gene;Acc:10... [more]
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BLAST of activin 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
INHBA3.377e-1231.67inhibin subunit beta A [Source:NCBI gene;Acc:10003... [more]
INHBC6.866e-1132.48inhibin subunit beta C [Source:HGNC Symbol;Acc:HGN... [more]
piwil43.668e-1028.21piwi-like RNA-mediated gene silencing 4 [Source:Xe... [more]
INHBB4.238e-826.90inhibin subunit beta B [Source:NCBI gene;Acc:10012... [more]
atrip3.314e-619.75ATR interacting protein [Source:Xenbase;Acc:XB-GEN... [more]
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BLAST of activin 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Inhbe4.965e-1227.33inhibin beta-E [Source:MGI Symbol;Acc:MGI:109269][more]
Inhba1.569e-1027.66inhibin beta-A [Source:MGI Symbol;Acc:MGI:96570][more]
Inhba1.569e-1027.66inhibin beta-A [Source:MGI Symbol;Acc:MGI:96570][more]
Inhbc4.545e-1028.00inhibin beta-C [Source:MGI Symbol;Acc:MGI:105932][more]
Inhbb5.807e-724.66inhibin beta-B [Source:MGI Symbol;Acc:MGI:96571][more]
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BLAST of activin 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|O88959|INHBE_RAT1.527e-1127.95Inhibin beta E chain OS=Rattus norvegicus OX=10116... [more]
sp|O08717|INHBE_MOUSE3.473e-1127.33Inhibin beta E chain OS=Mus musculus OX=10090 GN=I... [more]
sp|P58166|INHBE_HUMAN3.568e-1128.57Inhibin beta E chain OS=Homo sapiens OX=9606 GN=IN... [more]
sp|P55102|INHBA_HORSE6.065e-1031.03Inhibin beta A chain OS=Equus caballus OX=9796 GN=... [more]
sp|P18331|INHBA_RAT9.875e-1027.66Inhibin beta A chain OS=Rattus norvegicus OX=10116... [more]
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BLAST of activin 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
U3RA980.000e+0100.00Activin 1 OS=Schmidtea mediterranea OX=79327 PE=2 ... [more]
T1D1361.135e-1435.77Inhibin-1 OS=Dendrocoelum lacteum OX=27895 PE=2 SV... [more]
I1ZI681.369e-1233.93Inhibin-1 OS=Schmidtea mediterranea OX=79327 PE=2 ... [more]
A0A452I9Q11.048e-1127.62Inhibin subunit beta C OS=Gopherus agassizii OX=38... [more]
F1QPH93.268e-1129.02Inhibin subunit beta C OS=Danio rerio OX=7955 GN=L... [more]
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BLAST of activin 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
INHBC2.839e-1228.87inhibin beta B chain-like [Source:NCBI gene;Acc:10... [more]
inhbaa2.085e-1029.20inhibin beta A chain-like [Source:NCBI gene;Acc:10... [more]
INHBB7.977e-925.00inhibin beta B chain-like [Source:NCBI gene;Acc:10... [more]
inhbab8.576e-929.31inhibin beta A chain-like [Source:NCBI gene;Acc:10... [more]
mstnb5.497e-824.46myostatin [Source:NCBI gene;Acc:103027626][more]
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BLAST of activin 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 3
Match NameE-valueIdentityDescription
inhbab2.888e-928.99inhibin subunit beta Ab [Source:ZFIN;Acc:ZDB-GENE-... [more]
inhbb2.314e-824.20inhibin subunit beta B [Source:ZFIN;Acc:ZDB-GENE-9... [more]
ENSPMAT00000004249.12.366e-622.49pep scaffold:Pmarinus_7.0:GL479487:17949:23694:-1 ... [more]
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BLAST of activin 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of activin 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2
Match NameE-valueIdentityDescription
EDO348884.835e-827.64Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
MSTN3.714e-627.64Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of activin 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
INHBC2.172e-1227.69inhibin beta B chain [Source:NCBI gene;Acc:1011632... [more]
inhbaa3.576e-1227.50inhibin beta A chain [Source:NCBI gene;Acc:1011702... [more]
ENSORLT00000010146.23.666e-1130.22inhibin beta A chain [Source:NCBI gene;Acc:1001443... [more]
mstn2.959e-922.03myostatin [Source:NCBI gene;Acc:100529165][more]
INHBB3.240e-928.17inhibin subunit beta B [Source:NCBI gene;Acc:10116... [more]
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BLAST of activin 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000024833.10.000e+0100.00SMESG000024833.1[more]
SMESG000024833.10.000e+0100.00SMESG000024833.1[more]
SMESG000024831.11.607e-5298.82SMESG000024831.1[more]
SMESG000024831.13.372e-4498.63SMESG000024831.1[more]
SMESG000062806.13.985e-1633.93SMESG000062806.1[more]
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Cross References
External references for this transcript
DatabaseAccession
SmedGD GBrowseSMED30031091
GenBankAGX01005.1
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30031091 ID=SMED30031091|Name=activin 1|organism=Schmidtea mediterranea sexual|type=transcript|length=1782bp
AATCGGTAATGATTATAAAAGTTTTCCGTAAATCAAAACTATGAGCGCGC
ATATGTGTTTAAACTCATTTCAAGTGGCCCATTAGTTTATTCAAGTATTT
TTTAGATAATGAGCATCCTCTGTTTTAGATTTCAGAATTTATTATTCTGT
TATGTTGTCATTGTTTTTCATAAAGGTCTCGATATTGTTTCTATTGTTCG
AGAGGATGAGAGGTGAAACGTTTCACGATCTGGATCAACTGAAACGGAAG
TTGGCTATTACTCAATTCAGAAACAAACTGATTGACCATTTCAAAAAATT
CAAGATCGAGTCAGTTTTGACTGGGGTTAGCCATCATGAAGGAACTAAGA
CTAAAAACATCAATCGGATTCTCGCGGGCATTGAAAAGATTCAAGAAATT
CCATCGGAAAATCGGAAAACTGTTACCAAAATATTGGTTCTAGGTGTAAA
AGCGAATTCTTGCGTTAGGCCGAGTACTGCATGCATCGAGTTTCTTCTAC
CTCAAAAATTCTTTAATGAAAATATCAAATTGGCAAAGTTTCTGCTGGCT
GTTCCAGGCCGGAGAGGAGTTCTAATTAGATGGCAGATAGACCTAATAAT
AGGCCGAATGCAAATTGCCACTTTCAATATAAAATCAAGGCAGTTGCAAG
TCGGGATTCATGAAATAGAGTGCACCAATATTTTACAGTTGTTTTTCAGT
AAGTATAATCAAACTGATGGGAAAAAGATATTGAAGCTGGGATTGCGAGT
TCAATACAATGGGAAAGGGTTTCAAAAACCAAATGTTTACATACGAACTA
TAATCCTTTTGGCTTCAATGGCCTCTGCTAAGAGACGATATCCGAGAGCT
GCAGTTAAACAGTCGCCCTTAGTATGTACAAGTTCTTCGATATTTTGTTG
CATGAAAAATTTCACAGTAACCCCAACTGATCTGGGGTTACAAAACCTCA
TCAGTCCAGATTTGATTCATCTAAATTATTGCAAGGGAGACTGTAATCAT
TATTCTCCGTATAGAAGTAAACATGCGAGCTACCTTTCAATGCTGAAAAG
ATCCAAGACCTCCTTGCTATCCGCCAGACAACTCGAGACCATGAAAAACT
GTTGCACTCCCGTATTCTACAACAAATTACAAATCCAGTACCGAGATTAC
ACCCAAGATATCAGGAATACCGAAGTCAATGACATGATTGTCGAAAGTTG
CGGTTGCAATTAAAATCCGAAAAAATACAAAAATATTCTATTTGAATAAA
TTTATTTTCCTAATAATTTATTTTCGAGATTTCAATCTGATCTGTCAGGC
TTGCGTCTAATTTCATTAATTTCAACTTTTCCCTCATTTTCATTGGTTGA
CTCTGTCGGAGAAGTTTCCCTATAAAATCTGTAGAATTTCTGGTCATTTT
CGATTTTAAACAAAAACATAAAATAATATGGCTTTGATAAAAACACTCAA
CCTCCTGTTTGTCATGGGGACCGTTTTGGTCATTTTCACTGCAAATTCAA
ACACTGAAGAAGTGAAACGCTATGACACCGGCCATGATATATTTAGATTA
AAAAAAAGCTATCATTACTTTCGACTTAGACGAGCCTTGGACCAAATGAA
GTGCTCTAGGAACACTAATGACCTTGTGAATTTTATCGAAAAACACTGCA
TGGAAAAACCGGATTTCCTAGCACAAATGTTTTAATTCAAATTTCCTGAG
ATTCGGCAAAGATTTTTGTTCTGATTCTTGTTCATGAAAATGTAAAAGCT
TTTCTTGAATAAATTCGTAATTTCTTAGATCG
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protein sequence of SMED30031091-orf-1

>SMED30031091-orf-1 ID=SMED30031091-orf-1|Name=SMED30031091-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=354bp
MLSLFFIKVSILFLLFERMRGETFHDLDQLKRKLAITQFRNKLIDHFKKF
KIESVLTGVSHHEGTKTKNINRILAGIEKIQEIPSENRKTVTKILVLGVK
ANSCVRPSTACIEFLLPQKFFNENIKLAKFLLAVPGRRGVLIRWQIDLII
GRMQIATFNIKSRQLQVGIHEIECTNILQLFFSKYNQTDGKKILKLGLRV
QYNGKGFQKPNVYIRTIILLASMASAKRRYPRAAVKQSPLVCTSSSIFCC
MKNFTVTPTDLGLQNLISPDLIHLNYCKGDCNHYSPYRSKHASYLSMLKR
SKTSLLSARQLETMKNCCTPVFYNKLQIQYRDYTQDIRNTEVNDMIVESC
GCN*
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Aliases
The feature 'activin 1' has the following synonyms
Synonym
activin1
Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: biological process
TermDefinition
GO:0007165signal transduction
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000025nervous system
PLANA:0000026gut
PLANA:0000070intestinal phagocyte
PLANA:0000099neuron
PLANA:0000418head
Vocabulary: INTERPRO
TermDefinition
IPR015615TGF-beta-rel
IPR001839TGF-b_C
IPR029034Cystine-knot_cytokine
Vocabulary: molecular function
TermDefinition
GO:0008083growth factor activity
GO:0005179hormone activity
Vocabulary: cellular component
TermDefinition
GO:0005576extracellular region
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 323..343
NoneNo IPR availablePANTHERPTHR11848:SF256TRANSFORMING GROWTH FACTOR BETA FAMILYcoord: 221..353
NoneNo IPR availableSIGNALP_EUKSignalP-noTMSignalP-noTMcoord: 1..21
score: 0.745
IPR001839Transforming growth factor-beta, C-terminalSMARTSM00204TGFB_2coord: 249..353
e-value: 1.5E-7
score: 26.4
IPR001839Transforming growth factor-beta, C-terminalPFAMPF00019TGF_betacoord: 249..352
e-value: 5.1E-17
score: 62.8
IPR001839Transforming growth factor-beta, C-terminalPROSITEPS51362TGF_BETA_2coord: 229..353
score: 19.139
IPR029034Cystine-knot cytokineGENE3DG3DSA:2.10.90.10coord: 241..353
e-value: 4.9E-19
score: 70.9
IPR029034Cystine-knot cytokineSUPERFAMILYSSF57501Cystine-knot cytokinescoord: 244..352
IPR015615Transforming growth factor-beta-relatedPANTHERPTHR11848TGF-BETA FAMILYcoord: 221..353