Proprotein convertase subtilisin/kexin type 1

Query:  155 LLILCVFLVLTQA----EYQWEWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKA--QNWKNVPPMTTCRVK--------VKSSKMISNKLPATIIAYGNHCKEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKTTPDYIKNSK 1954
             ++ C +  L  A    ++  EWA +I  G  AA  IA++ G++ LG IG+L+N + F+ ++    R +RS    T+ LS   ++     Q    R KR +                 R   L +FNDP W  +WYL D+R  +     D+ V PVW   ITGKGV + +LDDGLE  H D+  NYDP +S D NDND DP P   P   N+HGTRCA EIAM ANN  CGVG+AYN K+GGIRMLDG V   IEA S+GFN  H+DIYS+SWGP DDGKT+E P +L Q+    G   GR GKG+IFVWASGNGG   D+C CDGY  S+Y IS++S +     P++AEKC ST+  +YS+   +   + +AD+   CT+ H+GTSASAP AAGIFAL LE NPNLTWRD++HL+ WTSEY+ + +N GWKKN AG  VN++FGFGLLNA  +V  A  + W++VP    C VK        +K++  +  ++P T    G   +  +  +E +     I Y  RG L + L S  G +T LL  R  D S +G  NW F SVH WGENP G W + + D ++      G + +  L  +GT + P+++K  +
Sbjct:   13 FVLFCAWCALNSAKAKRQFVNEWAAEIPGGPEAASAIAEELGYDLLGQIGSLENHYLFKHKNHPR-RSRRSAFHITKRLSDDDRVIWAEQQYEKERSKRSAL----------------RDSALNLFNDPMWNQQWYLQDTRMTAALPKLDLHVIPVWQKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFPRYDPTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATSYSSGDYTDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPLANNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPRTWRSVPEKKECVVKDNDFEPRALKANGEVIIEIP-TRACEGQ--ENAIKSLEHVQFEATIEYSRRGDLHVTLTSAAGTSTVLLAERERDTSPNGFKNWDFMSVHTWGENPIGTWTLRITD-MSGRIQNEGRIVNWKLILHGTSSQPEHMKQPR 605          

Query:  269 FEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKA--QNWKNVPPMTTCRVK--------VKSSKMISNKLPATIIAYGNHCKEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKTTPDYIKNSK 1954
            F +   IG+L+N + F+ ++    R +RS    T+ LS   ++     Q    R KR +                 R   L +FNDP W  +WYL D+R  +     D+ V PVW   ITGKGV + +LDDGLE  H D+  NYDP +S D NDND DP P   P   N+HGTRCA EIAM ANN  CGVG+AYN K+GGIRMLDG V   IEA S+GFN  H+DIYS+SWGP DDGKT+E P +L Q+    G   GR GKG+IFVWASGNGG   D+C CDGY  S+Y IS++S +     P++AEKC ST+  +YS+   +   + +AD+   CT+ H+GTSASAP AAGIFAL LE NPNLTWRD++HL+ WTSEY+ + +N GWKKN AG  VN++FGFGLLNA  +V  A  + W++VP    C VK        +K++  +  ++P T    G   +  +  +E +     I Y  RG L + L S  G +T LL  R  D S +G  NW F SVH WGENP G W + + D ++      G + +  L  +GT + P+++K  +
Sbjct:    8 FLFFSQIGSLENHYLFKHKNHPR-RSRRSAFHITKRLSDDDRVIWAEQQYEKERSKRSAL----------------RDSALNLFNDPMWNQQWYLQDTRMTAALPKLDLHVIPVWQKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFPRYDPTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATSYSSGDYTDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPLANNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPRTWRSVPEKKECVVKDNDFEPRALKANGEVIIEIP-TRACEGQ--ENAIKSLEHVQFEATIEYSRRGDLHVTLTSAAGTSTVLLAERERDTSPNGFKNWDFMSVHTWGENPIGTWTLRITD-MSGRIQNEGRIVNWKLILHGTSSQPEHMKQPR 558          

Query:  167 CVFLVLTQAEYQWEWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRN---LSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTCRVKV-KSSKMISNKLPATIIAYGNHCKEK----VAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDED--RSGEVTDCTLEFYGTKTTPDYIKNS--KTRRRNYDETMD 1987
            C+  V     Y   WAVKI  G   A  IA  +GF  +G IG L + +HF    +     KRSV S+      +S   K+  +  Q +  R KRD   +               R     FNDPKWP  WY+  S      +S DM +   W    TGK + V ILDDG+E THPDL+ NYD  +S D+N ND DP P       N+HGTRCA E+A +ANN  C VGIA+N KIGG+RMLDG V  ++EAKS+ FN  H+ IYS+SWGP DDGKT++ P+ L ++    G   GR G G++FVWASGNGG  +D CSCDGY +S+Y IS++S  +  K P++ E+C ST+  TYS+       +I  D++ +CT  H+GTSASAP AAGI AL LE NP LTWRD++H+I  TS    +  N  WK NAAGF V+  +GFGL++A  MV +A+ W  VP    C     +  K I        I   + C +     V ++E +++ + IT+  RG L I L SP G  + LL  R  D S +G  NW F ++H WGE   G WV+ V D  +   +    G++ + +L  YGT   P    N   K  R  Y    D
Sbjct:   25 CLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQIGALKDYYHFYHSRT----IKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFS---------------RAQSTYFNDPKWPSMWYMHCSDNTHPCQS-DMNIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNAN-DWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIRPNSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPYSPTNEFPKVERFRYSRVED 622          

Query:  167 CVFLVLTQAEYQWEWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRN---LSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTCRVKV-KSSKMISNKLPATIIAYGNHCKEK----VAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDED--RSGEVTDCTLEFYGTKTTPDYIKNS--KTRRRNYDETMD 1987
            C+  V     Y   WAVKI  G   A  IA  +GF  +G IG L + +HF    +     KRSV S+      +S   K+  +  Q +  R KRD   +               R     FNDPKWP  WY+  S      +S DM +   W    TGK + V ILDDG+E THPDL+ NYD  +S D+N ND DP P       N+HGTRCA E+A +ANN  C VGIA+N KIGG+RMLDG V  ++EAKS+ FN  H+ IYS+SWGP DDGKT++ P+ L ++    G   GR G G++FVWASGNGG  +D CSCDGY +S+Y IS++S  +  K P++ E+C ST+  TYS+       +I  D++ +CT  H+GTSASAP AAGI AL LE NP LTWRD++H+I  TS    +  N  WK NAAGF V+  +GFGL++A  MV +A+ W  VP    C     +  K I        I   + C +     V ++E +++ + IT+  RG L I L SP G  + LL  R  D S +G  NW F ++H WGE   G WV+ V D  +   +    G++ + +L  YGT   P    N   K  R  Y    D
Sbjct:   25 CLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQIGALKDYYHFYHSRT----IKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFS---------------RAQSTYFNDPKWPSMWYMHCSDNTHPCQS-DMNIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNAN-DWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIRPNSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPYSPTNEFPKVERFRYSRVED 622          

Query:  176 LVLTQAEYQWE------WAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTCRVKVKSS------KMISNKLPATIIAYGNHCKEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGT 1921
            LVL  A+ Q +      WAV+I  G   A  +A   GF  LG I    + +HF         + R V          +K S+  H+    R +R+ ++    +   + KR + +R V +   DPK+P +WYL      S     D+ V   W    TG G+ V+ILDDG+E  HPDL  NYDP +S D+ND D DP P  T    N HGTRCA E+A  ANN +CGVG+AYN +IGG+RMLDG V   +EA+SLG N NHI IYS+SWGP DDGKT++ P++L +E   RG   GR G G+IFVWASGNGG   DSC+CDGY +S+Y +S++S T     P+++E C ST+  TYS+ ++++  ++  D++ KCT+ H+GTSASAP AAGI AL LE N NLTWRD++HL+  TS+   +  N  W  N  G  V+  +G+GLL+A  MV  AQNW  V P   C + + +       ++   K     +   NH    +  +E     + ++Y  RG L I L SP G  +TLL  R  D S DG  +W F + H+W E+P+G+WV+ +E+    + +  G +T  TL  YGT
Sbjct:   17 LVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQI--FGDYYHF---------WHRGV----------TKRSLSPHRPRHSRLQREPQV--QWLEQQVAKR-RTKRDVYQEPTDPKFPQQWYL------SGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNAN-DWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKTVTACLGEPNH----ITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIEN--TSEANNYGTLTKFTLVLYGT 573          

Query:  242 AKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHN------IIKRLQHRRKVLEM-----------FNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTC----RVKVKSSKMISNKLPATIIAYGNHCKE--KVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGT 1921
            A+ IA D      G      + F +  E+++  R KR++      L  H  +  V  QR   R KRD  + D+ +HH+      ++ R   RR   +            F DP + D+WYL           YDM V   W     G+ V V+ILDDG++  HPDL  NYDP +STD+ND+DDDP+P       N+HGTRCA E+A  A N  CGVG+A+  KIGG+RMLDG V+  +EA SL  N +HIDIYS+SWGP DDGKT + P  L +E   RG  +GR GKGNIFVWASGNGG  QDSCS DGY +S+Y +S++S T DN  P++ E+CPS++  TYS++   + +++  DV G CT KH+GTSASAP AAGI AL LE NP LTWRD++HL+  T+ +  +++N GW +N  G  V+ KFG+GL++   +V  A+ WK VP    C    R+   + + I  +         N C+    V ++E + +   + Y  RG L + L SP G  + LL  R  D + +G   WPF SV  WGE+P G W++ VE  +  +   +G   D TL  YGT
Sbjct:   54 ARRIAADHDMHVKGDPFLDTHYFLYHSETTRTRRHKRAI---VERLDSHPAVEWVEEQRPKKRVKRDYILLDNDVHHSNPFRRSVLNRDGTRRAQRQQPQSPREIPSLPFPDPLYKDQWYLHGGAV----GGYDMNVRQAWLQGYAGRNVSVSILDDGIQRDHPDLAANYDPLASTDINDHDDDPTPQNNG--DNKHGTRCAGEVAALAGNNQCGVGVAFKAKIGGVRMLDGAVSDSVEAASLSLNQDHIDIYSASWGPEDDGKTFDGPGPLAREAFYRGIKNGRGGKGNIFVWASGNGGSRQDSCSADGYTTSVYTLSISSATYDNHRPWYLEECPSSIATTYSSADFRQPAIVTVDVPGGCTDKHTGTSASAPLAAGIIALALEANPELTWRDMQHLVLRTANWKPLENNPGWSRNGVGRMVSNKFGYGLIDGGALVNMAKTWKTVPEQHICTYEYRLANPNPRPIVGRFQLNFTLDVNGCESGTPVLYLEHVQVHATVRYLKRGDLKLTLFSPSGTRSVLLPPRPQDFNANGFHKWPFLSVQQWGEDPRGTWLLMVE-SVTTNPAATGTFHDWTLLLYGT 626          

Query:  242 AKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHN------IIKRLQHRRKVLEM-----------FNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTC----RVKVKSSKMISNKLPATIIAYGNHCKE--KVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGT 1921
            A+ IA D      G      + F +  E+++  R KR++      L  H  +  V  QR   R KRD  + D+ +HH+      ++ R   RR   +            F DP + D+WYL           YDM V   W     G+ V V+ILDDG++  HPDL  NYDP +STD+ND+DDDP+P       N+HGTRCA E+A  A N  CGVG+A+  KIGG+RMLDG V+  +EA SL  N +HIDIYS+SWGP DDGKT + P  L +E   RG  +GR GKGNIFVWASGNGG  QDSCS DGY +S+Y +S++S T DN  P++ E+CPS++  TYS++   + +++  DV G CT KH+GTSASAP AAGI AL LE NP LTWRD++HL+  T+ +  +++N GW +N  G  V+ KFG+GL++   +V  A+ WK VP    C    R+   + + I  +         N C+    V ++E + +   + Y  RG L + L SP G  + LL  R  D + +G   WPF SV  WGE+P G W++ VE  +  +   +G   D TL  YGT
Sbjct:   54 ARRIAADHDMHVKGDPFLDTHYFLYHSETTRTRRHKRAI---VERLDSHPAVEWVEEQRPKKRVKRDYILLDNDVHHSNPFRRSVLNRDGTRRAQRQQPQSPREIPSLPFPDPLYKDQWYLHGGAV----GGYDMNVRQAWLQGYAGRNVSVSILDDGIQRDHPDLAANYDPLASTDINDHDDDPTPQNNG--DNKHGTRCAGEVAALAGNNQCGVGVAFKAKIGGVRMLDGAVSDSVEAASLSLNQDHIDIYSASWGPEDDGKTFDGPGPLAREAFYRGIKNGRGGKGNIFVWASGNGGSRQDSCSADGYTTSVYTLSISSATYDNHRPWYLEECPSSIATTYSSADFRQPAIVTVDVPGGCTDKHTGTSASAPLAAGIIALALEANPELTWRDMQHLVLRTANWKPLENNPGWSRNGVGRMVSNKFGYGLIDGGALVNMAKTWKTVPEQHICTYEYRLANPNPRPIVGRFQLNFTLDVNGCESGTPVLYLEHVQVHATVRYLKRGDLKLTLFSPSGTRSVLLPPRPQDFNANGFHKWPFLSVQQWGEDPRGTWLLMVE-SVTTNPAATGTFHDWTLLLYGT 626          

Query:  242 AKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHN------IIKRLQHRRKVLEM-----------FNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTC----RVKVKSSKMISNKLPATIIAYGNHCKE--KVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGT 1921
            A+ IA D      G      + F +  E+++  R KR++      L  H  +  V  QR   R KRD  + D+ +HH+      ++ R   RR   +            F DP + D+WYL           YDM V   W     G+ V V+ILDDG++  HPDL  NYDP +STD+ND+DDDP+P       N+HGTRCA E+A  A N  CGVG+A+  KIGG+RMLDG V+  +EA SL  N +HIDIYS+SWGP DDGKT + P  L +E   RG  +GR GKGNIFVWASGNGG  QDSCS DGY +S+Y +S++S T DN  P++ E+CPS++  TYS++   + +++  DV G CT KH+GTSASAP AAGI AL LE NP LTWRD++HL+  T+ +  +++N GW +N  G  V+ KFG+GL++   +V  A+ WK VP    C    R+   + + I  +         N C+    V ++E + +   + Y  RG L + L SP G  + LL  R  D + +G   WPF SV  WGE+P G W++ VE  +  +   +G   D TL  YGT
Sbjct:   54 ARRIAADHDMHVKGDPFLDTHYFLYHSETTRTRRHKRAI---VERLDSHPAVEWVEEQRPKKRVKRDYILLDNDVHHSNPFRRSVLNRDGTRRAQRQQPQSPREIPSLPFPDPLYKDQWYLHGGAV----GGYDMNVRQAWLQGYAGRNVSVSILDDGIQRDHPDLAANYDPLASTDINDHDDDPTPQNNG--DNKHGTRCAGEVAALAGNNQCGVGVAFKAKIGGVRMLDGAVSDSVEAASLSLNQDHIDIYSASWGPEDDGKTFDGPGPLAREAFYRGIKNGRGGKGNIFVWASGNGGSRQDSCSADGYTTSVYTLSISSATYDNHRPWYLEECPSSIATTYSSADFRQPAIVTVDVPGGCTDKHTGTSASAPLAAGIIALALEANPELTWRDMQHLVLRTANWKPLENNPGWSRNGVGRMVSNKFGYGLIDGGALVNMAKTWKTVPEQHICTYEYRLANPNPRPIVGRFQLNFTLDVNGCESGTPVLYLEHVQVHATVRYLKRGDLKLTLFSPSGTRSVLLPPRPQDFNANGFHKWPFLSVQQWGEDPRGTWLLMVE-SVTTNPAATGTFHDWTLLLYGT 626          

Query:  242 AKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHN------IIKRLQHRRKVLEM-----------FNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTC----RVKVKSSKMISNKLPATIIAYGNHCKE--KVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGT 1921
            A+ IA D      G      + F +  E+++  R KR++      L  H  +  V  QR   R KRD  + D+ +HH+      ++ R   RR   +            F DP + D+WYL           YDM V   W     G+ V V+ILDDG++  HPDL  NYDP +STD+ND+DDDP+P       N+HGTRCA E+A  A N  CGVG+A+  KIGG+RMLDG V+  +EA SL  N +HIDIYS+SWGP DDGKT + P  L +E   RG  +GR GKGNIFVWASGNGG  QDSCS DGY +S+Y +S++S T DN  P++ E+CPS++  TYS++   + +++  DV G CT KH+GTSASAP AAGI AL LE NP LTWRD++HL+  T+ +  +++N GW +N  G  V+ KFG+GL++   +V  A+ WK VP    C    R+   + + I  +         N C+    V ++E + +   + Y  RG L + L SP G  + LL  R  D + +G   WPF SV  WGE+P G W++ VE  +  +   +G   D TL  YGT
Sbjct:   54 ARRIAADHDMHVKGDPFLDTHYFLYHSETTRTRRHKRAI---VERLDSHPAVEWVEEQRPKKRVKRDYILLDNDVHHSNPFRRSVLNRDGTRRAQRQQPQSPREIPSLPFPDPLYKDQWYLHGGAV----GGYDMNVRQAWLQGYAGRNVSVSILDDGIQRDHPDLAANYDPLASTDINDHDDDPTPQNNG--DNKHGTRCAGEVAALAGNNQCGVGVAFKAKIGGVRMLDGAVSDSVEAASLSLNQDHIDIYSASWGPEDDGKTFDGPGPLAREAFYRGIKNGRGGKGNIFVWASGNGGSRQDSCSADGYTTSVYTLSISSATYDNHRPWYLEECPSSIATTYSSADFRQPAIVTVDVPGGCTDKHTGTSASAPLAAGIIALALEANPELTWRDMQHLVLRTANWKPLENNPGWSRNGVGRMVSNKFGYGLIDGGALVNMAKTWKTVPEQHICTYEYRLANPNPRPIVGRFQLNFTLDVNGCESGTPVLYLEHVQVHATVRYLKRGDLKLTLFSPSGTRSVLLPPRPQDFNANGFHKWPFLSVQQWGEDPRGTWLLMVE-SVTTNPAATGTFHDWTLLLYGT 626          

Query:  242 AKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHN------IIKRLQHRRKVLEM-----------FNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTC----RVKVKSSKMISNKLPATIIAYGNHCKE--KVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGT 1921
            A+ IA D      G      + F +  E+++  R KR++      L  H  +  V  QR   R KRD  + D+ +HH+      ++ R   RR   +            F DP + D+WYL           YDM V   W     G+ V V+ILDDG++  HPDL  NYDP +STD+ND+DDDP+P       N+HGTRCA E+A  A N  CGVG+A+  KIGG+RMLDG V+  +EA SL  N +HIDIYS+SWGP DDGKT + P  L +E   RG  +GR GKGNIFVWASGNGG  QDSCS DGY +S+Y +S++S T DN  P++ E+CPS++  TYS++   + +++  DV G CT KH+GTSASAP AAGI AL LE NP LTWRD++HL+  T+ +  +++N GW +N  G  V+ KFG+GL++   +V  A+ WK VP    C    R+   + + I  +         N C+    V ++E + +   + Y  RG L + L SP G  + LL  R  D + +G   WPF SV  WGE+P G W++ VE  +  +   +G   D TL  YGT
Sbjct:   54 ARRIAADHDMHVKGDPFLDTHYFLYHSETTRTRRHKRAI---VERLDSHPAVEWVEEQRPKKRVKRDYILLDNDVHHSNPFRRSVLNRDGTRRAQRQQPQSPREIPSLPFPDPLYKDQWYLHGGAV----GGYDMNVRQAWLQGYAGRNVSVSILDDGIQRDHPDLAANYDPLASTDINDHDDDPTPQNNG--DNKHGTRCAGEVAALAGNNQCGVGVAFKAKIGGVRMLDGAVSDSVEAASLSLNQDHIDIYSASWGPEDDGKTFDGPGPLAREAFYRGIKNGRGGKGNIFVWASGNGGSRQDSCSADGYTTSVYTLSISSATYDNHRPWYLEECPSSIATTYSSADFRQPAIVTVDVPGGCTDKHTGTSASAPLAAGIIALALEANPELTWRDMQHLVLRTANWKPLENNPGWSRNGVGRMVSNKFGYGLIDGGALVNMAKTWKTVPEQHICTYEYRLANPNPRPIVGRFQLNFTLDVNGCESGTPVLYLEHVQVHATVRYLKRGDLKLTLFSPSGTRSVLLPPRPQDFNANGFHKWPFLSVQQWGEDPRGTWLLMVE-SVTTNPAATGTFHDWTLLLYGT 626          

Query:  191 AEYQWEWAVKIEDGETA-AKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRN---LSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEM-------FNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTCRVKVKS-SKMISNKLPATIIAYGNHCKEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKT--TPDYIKN 1948
              Y   WAV I +G+   A  +A D GF  LG I   D+ +HF          KRS+  AT +   L    ++     QR   R KRD            I+    R     M       FND KWP  WYL      +     DM V P W M ITGKGV V ILDDGLE  HPD+ DNYDP +S D+N +DDDP P      SN HGTRCA E+A +ANN  C VGIAY   +GG+RMLDG V   +EA+SL  N  HIDIYS+SWGP DDGKT++ P +L       G   GR GKG+IF+WASGNGG  QD+C+CDGY +S++ +S++S T++   P+++EKC ST+  TYS+  + +  ++  D+   CT  H+GTSASAP AAGI ALVL+ N NLTWRD++H++  T++   +KD   W +N  G  V+  FG+GL++A +MV+ A+NWK VP    C +      K+I  +   T+    NHC+  V ++E +   + +T + RG + + L+SP   + TLLT R  D S+ G   WPF SVH WGE+P G W +    +I+++     ++T   + FYGT+T   PD + N
Sbjct:  229 GHYTHTWAVHIPNGDNGMADAVAKDHGFVNLGKI--FDDHYHFAHHKVS----KRSLSPATHHQTRLDDDDRVHWAKQQRAKSRSKRD-----------FIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYL------NRGGGLDMNVIPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMTDSNRHGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQHIDIYSASWGPDDDGKTVDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNSIWTLSISSATEEGHVPWYSEKCSSTLATTYSSGGQGEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLTWRDLQHIVVRTAKPANLKD-PSWSRNGVGRRVSHSFGYGLMDAAEMVRVARNWKAVPEQQRCEINAPHVDKVIPPRTHITLQLTVNHCR-SVNYLEHVQAKITLTSQRRGDIQLFLRSPANTSVTLLTPRIHDNSRSGFNQWPFMSVHTWGESPQGNWQL----EIHNEGRYMAQITQWDMIFYGTETPAQPDDVAN 799          

Query:  191 AEYQWEWAVKIEDGETA-AKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRN---LSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEM-------FNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTCRVKVKS-SKMISNKLPATIIAYGNHCKEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKT--TPDYIKN 1948
              Y   WAV I +G+   A  +A D GF  LG I   D+ +HF          KRS+  AT +   L    ++     QR   R KRD            I+    R     M       FND KWP  WYL      +     DM V P W M ITGKGV V ILDDGLE  HPD+ DNYDP +S D+N +DDDP P      SN HGTRCA E+A +ANN  C VGIAY   +GG+RMLDG V   +EA+SL  N  HIDIYS+SWGP DDGKT++ P +L       G   GR GKG+IF+WASGNGG  QD+C+CDGY +S++ +S++S T++   P+++EKC ST+  TYS+  + +  ++  D+   CT  H+GTSASAP AAGI ALVL+ N NLTWRD++H++  T++   +KD   W +N  G  V+  FG+GL++A +MV+ A+NWK VP    C +      K+I  +   T+    NHC+  V ++E +   + +T + RG + + L+SP   + TLLT R  D S+ G   WPF SVH WGE+P G W +    +I+++     ++T   + FYGT+T   PD + N
Sbjct:  229 GHYTHTWAVHIPNGDNGMADAVAKDHGFVNLGKI--FDDHYHFAHHKVS----KRSLSPATHHQTRLDDDDRVHWAKQQRAKSRSKRD-----------FIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYL------NRGGGLDMNVIPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMTDSNRHGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQHIDIYSASWGPDDDGKTVDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNSIWTLSISSATEEGHVPWYSEKCSSTLATTYSSGGQGEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLTWRDLQHIVVRTAKPANLKD-PSWSRNGVGRRVSHSFGYGLMDAAEMVRVARNWKAVPEQQRCEINAPHVDKVIPPRTHITLQLTVNHCRS-VNYLEHVQAKITLTSQRRGDIQLFLRSPANTSVTLLTPRIHDNSRSGFNQWPFMSVHTWGESPQGNWQL----EIHNEGRYMAQITQWDMIFYGTETPAQPDDVAN 799          

Query:  191 AEYQWEWAVKIEDGETA-AKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRN---LSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEM-------FNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTCRVKVKS-SKMISNKLPATIIAYGNHCKEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKT--TPDYIKN 1948
              Y   WAV I +G+   A  +A D GF  LG I   D+ +HF          KRS+  AT +   L    ++     QR   R KRD            I+    R     M       FND KWP  WYL      +     DM V P W M ITGKGV V ILDDGLE  HPD+ DNYDP +S D+N +DDDP P      SN HGTRCA E+A +ANN  C VGIAY   +GG+RMLDG V   +EA+SL  N  HIDIYS+SWGP DDGKT++ P +L       G   GR GKG+IF+WASGNGG  QD+C+CDGY +S++ +S++S T++   P+++EKC ST+  TYS+  + +  ++  D+   CT  H+GTSASAP AAGI ALVL+ N NLTWRD++H++  T++   +KD   W +N  G  V+  FG+GL++A +MV+ A+NWK VP    C +      K+I  +   T+    NHC+  V ++E +   + +T + RG + + L+SP   + TLLT R  D S+ G   WPF SVH WGE+P G W +    +I+++     ++T   + FYGT+T   PD + N
Sbjct:  229 GHYTHTWAVHIPNGDNGMADAVAKDHGFVNLGKI--FDDHYHFAHHKVS----KRSLSPATHHQTRLDDDDRVHWAKQQRAKSRSKRD-----------FIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYL------NRGGGLDMNVIPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMTDSNRHGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQHIDIYSASWGPDDDGKTVDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNSIWTLSISSATEEGHVPWYSEKCSSTLATTYSSGGQGEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLTWRDLQHIVVRTAKPANLKD-PSWSRNGVGRRVSHSFGYGLMDAAEMVRVARNWKAVPEQQRCEINAPHVDKVIPPRTHITLQLTVNHCRS-VNYLEHVQAKITLTSQRRGDIQLFLRSPANTSVTLLTPRIHDNSRSGFNQWPFMSVHTWGESPQGNWQL----EIHNEGRYMAQITQWDMIFYGTETPAQPDDVAN 799          

Query:  191 AEYQWEWAVKIEDGETA-AKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRN---LSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEM-------FNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTCRVKVKS-SKMISNKLPATIIAYGNHCKEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKT--TPDYIKN 1948
              Y   WAV I +G+   A  +A D GF  LG I   D+ +HF          KRS+  AT +   L    ++     QR   R KRD            I+    R     M       FND KWP  WYL      +     DM V P W M ITGKGV V ILDDGLE  HPD+ DNYDP +S D+N +DDDP P      SN HGTRCA E+A +ANN  C VGIAY   +GG+RMLDG V   +EA+SL  N  HIDIYS+SWGP DDGKT++ P +L       G   GR GKG+IF+WASGNGG  QD+C+CDGY +S++ +S++S T++   P+++EKC ST+  TYS+  + +  ++  D+   CT  H+GTSASAP AAGI ALVL+ N NLTWRD++H++  T++   +KD   W +N  G  V+  FG+GL++A +MV+ A+NWK VP    C +      K+I  +   T+    NHC+  V ++E +   + +T + RG + + L+SP   + TLLT R  D S+ G   WPF SVH WGE+P G W +    +I+++     ++T   + FYGT+T   PD + N
Sbjct:  229 GHYTHTWAVHIPNGDNGMADAVAKDHGFVNLGKI--FDDHYHFAHHKVS----KRSLSPATHHQTRLDDDDRVHWAKQQRAKSRSKRD-----------FIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYL------NRGGGLDMNVIPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMTDSNRHGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQHIDIYSASWGPDDDGKTVDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNSIWTLSISSATEEGHVPWYSEKCSSTLATTYSSGGQGEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLTWRDLQHIVVRTAKPANLKD-PSWSRNGVGRRVSHSFGYGLMDAAEMVRVARNWKAVPEQQRCEINAPHVDKVIPPRTHITLQLTVNHCRS-VNYLEHVQAKITLTSQRRGDIQLFLRSPANTSVTLLTPRIHDNSRSGFNQWPFMSVHTWGESPQGNWQL----EIHNEGRYMAQITQWDMIFYGTETPAQPDDVAN 799          

Query:  191 AEYQWEWAVKIEDGETA-AKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRN---LSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEM-------FNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTCRVKVKS-SKMISNKLPATIIAYGNHCKEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKT--TPDYIKN 1948
              Y   WAV I +G+   A  +A D GF  LG I   D+ +HF          KRS+  AT +   L    ++     QR   R KRD            I+    R     M       FND KWP  WYL      +     DM V P W M ITGKGV V ILDDGLE  HPD+ DNYDP +S D+N +DDDP P      SN HGTRCA E+A +ANN  C VGIAY   +GG+RMLDG V   +EA+SL  N  HIDIYS+SWGP DDGKT++ P +L       G   GR GKG+IF+WASGNGG  QD+C+CDGY +S++ +S++S T++   P+++EKC ST+  TYS+  + +  ++  D+   CT  H+GTSASAP AAGI ALVL+ N NLTWRD++H++  T++   +KD   W +N  G  V+  FG+GL++A +MV+ A+NWK VP    C +      K+I  +   T+    NHC+  V ++E +   + +T + RG + + L+SP   + TLLT R  D S+ G   WPF SVH WGE+P G W +    +I+++     ++T   + FYGT+T   PD + N
Sbjct:  229 GHYTHTWAVHIPNGDNGMADAVAKDHGFVNLGKI--FDDHYHFAHHKVS----KRSLSPATHHQTRLDDDDRVHWAKQQRAKSRSKRD-----------FIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYL------NRGGGLDMNVIPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMTDSNRHGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQHIDIYSASWGPDDDGKTVDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNSIWTLSISSATEEGHVPWYSEKCSSTLATTYSSGGQGEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLTWRDLQHIVVRTAKPANLKD-PSWSRNGVGRRVSHSFGYGLMDAAEMVRVARNWKAVPEQQRCEINAPHVDKVIPPRTHITLQLTVNHCRS-VNYLEHVQAKITLTSQRRGDIQLFLRSPANTSVTLLTPRIHDNSRSGFNQWPFMSVHTWGESPQGNWQL----EIHNEGRYMAQITQWDMIFYGTETPAQPDDVAN 799          

Query:  158 LILCVFLVLTQA--------EYQWEWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQN--WKNVPPMTTCRVK--------VKSSKMISNKLPATIIAYGNHCKEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKTTPDYIKNSK 1954
            ++LC  L L  A        +Y  EWAV+I  G   A+ IAD+FG++ +  IG L+N + F++ S  + R KRS +  T+ LS+  ++S    Q    R KR     +                V ++F+DP W  +WYL D+R  S     D+ V PVW   ITGKGV + +LDDGLE  H D+  NYDP +S D NDND DP P       N+HGTRCA EIAM A+N  CGVG+AYN K+GGIRMLDG V   IEA S+G+N +H+DIYS+SWGP DDGKT+E P +L Q+    G   GR GKG+IFVWASGNGG   D+C CDGY  SLY IS++S +     P++AEKC ST+   YS+   +   + +AD+  +CT+ H+GTSASAP AAGIFAL LE NP+LTWRD++HL+ WTSE++ + +N GWK+N AG  VN++FGFGLLNA  +V  A    WK+VP    C V+        +K++  IS ++P    A   +    V  +E + + ++I Y  RG L I L SP G  T LL  R  D S +G  NW F SVH WGENPTG W++ + D     E+  G++    L  +GT   P+++K ++
Sbjct:    8 MLLCSVLALVCALVSSAVDRQYLNEWAVEIPGGVQNARSIADEFGYQLVRQIGALENHYLFKRHSHPS-RTKRSADHITKRLSEDDRVSWAEQQYEKRRAKRAPLGVEC-----------KDCSVDKLFDDPMWNQQWYLQDTRTSSSLPKLDLHVIPVWKKGITGKGVVITVLDDGLEWNHTDIYPNYDPAASYDFNDNDPDPFPRYDSTNENKHGTRCAGEIAMQADNNKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGYNPDHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGIQKGRGGKGSIFVWASGNGGRQGDNCDCDGYTDSLYTISISSASQQGLSPWYAEKCSSTLATAYSSGDYTDQRITSADLHNECTETHTGTSASAPLAAGIFALALEQNPDLTWRDLQHLVVWTSEFDPLANNPGWKRNGAGLMVNSRFGFGLLNAKALVDLADPKVWKHVPEKKQCIVRDETFQPRPLKAAGEISIEIPTKACAGQAN---SVMSLEHVQVEVSIEYTRRGDLHITLTSPSGTTTVLLAERERDTSSNGFRNWAFMSVHTWGENPTGTWILKITDTSGRMENE-GQIISWKLILHGTSEKPEHMKKAR 608          

Query:  158 LILCVFLVLTQA--------EYQWEWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQN--WKNVPPMTTCRVK--------VKSSKMISNKLPATIIAYGNHCKEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKTTPDYIKNSK 1954
            ++LC  L L  A        +Y  EWAV+I  G   A+ IAD+FG++ +  IG L+N + F++ S  + R KRS +  T+ LS+  ++S    Q    R KR     +                V ++F+DP W  +WYL D+R  S     D+ V PVW   ITGKGV + +LDDGLE  H D+  NYDP +S D NDND DP P       N+HGTRCA EIAM A+N  CGVG+AYN K+GGIRMLDG V   IEA S+G+N +H+DIYS+SWGP DDGKT+E P +L Q+    G   GR GKG+IFVWASGNGG   D+C CDGY  SLY IS++S +     P++AEKC ST+   YS+   +   + +AD+  +CT+ H+GTSASAP AAGIFAL LE NP+LTWRD++HL+ WTSE++ + +N GWK+N AG  VN++FGFGLLNA  +V  A    WK+VP    C V+        +K++  IS ++P    A   +    V  +E + + ++I Y  RG L I L SP G  T LL  R  D S +G  NW F SVH WGENPTG W++ + D     E+  G++    L  +GT   P+++K ++
Sbjct:    8 MLLCSVLALVCALVSSAVDRQYLNEWAVEIPGGVQNARSIADEFGYQLVRQIGALENHYLFKRHSHPS-RTKRSADHITKRLSEDDRVSWAEQQYEKRRAKRAPLGVEC-----------KDCSVDKLFDDPMWNQQWYLQDTRTSSSLPKLDLHVIPVWKKGITGKGVVITVLDDGLEWNHTDIYPNYDPAASYDFNDNDPDPFPRYDSTNENKHGTRCAGEIAMQADNNKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGYNPDHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGIQKGRGGKGSIFVWASGNGGRQGDNCDCDGYTDSLYTISISSASQQGLSPWYAEKCSSTLATAYSSGDYTDQRITSADLHNECTETHTGTSASAPLAAGIFALALEQNPDLTWRDLQHLVVWTSEFDPLANNPGWKRNGAGLMVNSRFGFGLLNAKALVDLADPKVWKHVPEKKQCIVRDETFQPRPLKAAGEISIEIPTKACAGQAN---SVMSLEHVQVEVSIEYTRRGDLHITLTSPSGTTTVLLAERERDTSSNGFRNWAFMSVHTWGENPTGTWILKITDTSGRMENE-GQIISWKLILHGTSEKPEHMKKAR 608          

Query:  143 VFRNLLILCVFLVLTQAEYQWEWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEM-----FNDPKWPDEWYLFDSRFDSDQKSY-DMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTCRVKV-KSSKMISNKLPATIIAYGNHCK----EKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDR--SGEVTDCTLEFYGTKTTPDYIKNSKTRRRNYDETMDEDEI 1999
            +F  + + CV + L    Y   WAVKI  G  AA  IA+ +GF  +G IG L + + F+     +G  KRS   +  N   HS I+M            ++K+    I   ++++   R + ++      FNDPKW   WY+       D     DM +   W    TGKGV V+ILDDG+E  HPDL  NYD  +S D+N ND DP+P       N+HGTRCA  +A SANN +C VGIAYN KIGG+RMLDG +  ++EA+SL     +IDIYSSSWGP DDG+T++ P  L +  L  G   GR G+G+IFVWASGNGG  QD CSCDGY +S+Y ISV S T   + P++ E+C ST+  TYS+       ++  D++ +CT +HSGTSASAP AAGI AL LE NP LTWRDI+H+I  TS    +  +  W+ N AG+ V+  +GFGLLNA  MVK A+ WK VP    C   + +++++IS +     +   + C     ++V ++E +I+ + IT+  RG L I L SP G  + LL  R  D S +G I W F + H WGE   G W++ + D  +   +    G++ + +L  YGT T P YI++ + R     +   EDEI
Sbjct:   11 LFFGIGLQCVQMRL----YTNRWAVKITGGPEAADLIAEKYGFVNMGQIGGLVDHYQFQH----SGIIKRSTIKSKGN---HSLITM------------ETKV--EWIQQQMVQKRVKRTETMDQTHDGSFNDPKWDSMWYIH-----CDHNCLTDMNIQAAWRRGYTGKGVVVSILDDGIERQHPDLKQNYDARASYDVNGNDPDPTPRYDVTNENKHGTRCAGVVAASANNSLCIVGIAYNAKIGGVRMLDGDMTDMVEAQSLNLRQQYIDIYSSSWGPDDDGRTVDGPGPLARLALENGIRKGRKGRGSIFVWASGNGGQSQDHCSCDGYTNSIYTISVGSTTQSGRKPWYLEECSSTLATTYSSGDSHSPGVVTTDLRQRCTDEHSGTSASAPMAAGIIALTLEANPALTWRDIQHIIVKTSSRGHLSAS-DWQSNGAGYDVSHLYGFGLLNAEAMVKNAETWKQVPSQHICEENIGQNARIISPERVLRSVLKSSGCSAQRLQRVVYLEHVIVRVTITHPHRGDLSITLTSPSGTTSQLLANRPNDHSSEGFIKWEFMTTHCWGERLAGDWILDIRDTPSPQRNNRLQGKLVEWSLVLYGTSTHP-YIRHEQPRSA---QLPSEDEI 607          

Query:  143 VFRNLLILCVFLVLTQAEYQWEWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEM-----FNDPKWPDEWYLFDSRFDSDQKSY-DMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTCRVKV-KSSKMISNKLPATIIAYGNHCK----EKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDR--SGEVTDCTLEFYGTKTTPDYIKNSKTRRRNYDETMDEDEI 1999
            +F  + + CV + L    Y   WAVKI  G  AA  IA+ +GF  +G IG L + + F+     +G  KRS   +  N   HS I+M            ++K+    I   ++++   R + ++      FNDPKW   WY+       D     DM +   W    TGKGV V+ILDDG+E  HPDL  NYD  +S D+N ND DP+P       N+HGTRCA  +A SANN +C VGIAYN KIGG+RMLDG +  ++EA+SL     +IDIYSSSWGP DDG+T++ P  L +  L  G   GR G+G+IFVWASGNGG  QD CSCDGY +S+Y ISV S T   + P++ E+C ST+  TYS+       ++  D++ +CT +HSGTSASAP AAGI AL LE NP LTWRDI+H+I  TS    +  +  W+ N AG+ V+  +GFGLLNA  MVK A+ WK VP    C   + +++++IS +     +   + C     ++V ++E +I+ + IT+  RG L I L SP G  + LL  R  D S +G I W F + H WGE   G W++ + D  +   +    G++ + +L  YGT T P YI++ + R     +   EDEI
Sbjct:   11 LFFGIGLQCVQMRL----YTNRWAVKITGGPEAADLIAEKYGFVNMGQIGGLVDHYQFQH----SGIIKRSTIKSKGN---HSLITM------------ETKV--EWIQQQMVQKRVKRTETMDQTHDGSFNDPKWDSMWYIH-----CDHNCLTDMNIQAAWRRGYTGKGVVVSILDDGIERQHPDLKQNYDARASYDVNGNDPDPTPRYDVTNENKHGTRCAGVVAASANNSLCIVGIAYNAKIGGVRMLDGDMTDMVEAQSLNLRQQYIDIYSSSWGPDDDGRTVDGPGPLARLALENGIRKGRKGRGSIFVWASGNGGQSQDHCSCDGYTNSIYTISVGSTTQSGRKPWYLEECSSTLATTYSSGDSHSPGVVTTDLRQRCTDEHSGTSASAPMAAGIIALTLEANPALTWRDIQHIIVKTSSRGHLSAS-DWQSNGAGYDVSHLYGFGLLNAEAMVKNAETWKQVPSQHICEENIGQNARIISPERVLRSVLKSSGCSAQRLQRVVYLEHVIVRVTITHPHRGDLSITLTSPSGTTSQLLANRPNDHSSEGFIKWEFMTTHCWGERSAGDWILDIRDTPSPQRNTRLQGKLVEWSLVLYGTSTHP-YIRHEQPRSA---QLPSEDEI 607          

Query:  182 LTQAEYQWEWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTCRVKVKS------SKMISNKLPATIIAYGNHCKEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKTT 1930
            + Q  Y   WAV IE GE  A  IA    F   G +    + +HFR          R+V    R+LS+H    + +H          ++         ++KR + +R V     DPK+  +WYL++      Q   D+ V   W   +TG+GV V+ILDDG+E  HPDL+ NYDP +S D+ND D DP P  T    N HGTRCA E+A  A+N ICGVG+AYN +IGG+RMLDG V  ++EA+SL  N  HIDIYS+SWGP DDGKT++ P+KL +E  +RG + GR G+G+IFVWASGNGG  +DSC+CDGY +S+Y +S++S T +   P+++E C ST+ +TYS+   ++  ++  D++ KCT  H+GTSASAP AAGI AL LE N NLTWRD++HL+  TS    +  N  WK N  G  V+  +G+GLL+A  +V  A+NW NV P   C + + S      S ++ NK         N     V+ +E +   + ++Y  RG L I L SP G  +TLL  R  D S +G  +W F + H+W E+P G+W + +++     +   G +T  TL  YGT ++
Sbjct:   25 IGQKVYTNTWAVHIEGGEEEADRIARKHSFVNHGNV--FGDYYHFRH---------RTV--VKRSLSEHRGTHIRLH----------TEPQVMWAEQQVVKR-RKKRDVYYEPTDPKFAQQWYLYN------QDHLDLNVKNAWKQGVTGQGVVVSILDDGIEKNHPDLVQNYDPDASYDVNDGDPDPQPRYTQLNDNRHGTRCAGEVAAVADNDICGVGVAYNARIGGVRMLDGEVTDVVEAQSLSLNPQHIDIYSASWGPEDDGKTVDGPAKLAKEAFQRGVIEGRGGRGSIFVWASGNGGRMKDSCNCDGYTNSIYTLSISSSTQNGNVPWYSEACSSTLASTYSSGGVNEKQIVTTDLRQKCTDSHTGTSASAPLAAGIIALALEANKNLTWRDMQHLVVRTSNPAHLTTN-DWKINGVGRRVSHSYGYGLLDAGAIVALAKNWTNVGPQHKCVLSLVSEPRNIGSYLVINKTVDACTGMANF----VSSLEHVQAQLTLSYNRRGNLAIYLISPQGTRSTLLPPRPHDYSSEGFNDWAFMTTHSWDEDPRGEWTLEIKNVAGTSD--YGTLTQFTLVLYGTASS 576          

Query:  107 KHWFLNKMNDVQVFRNLLILC-VFLVLTQAEYQWEWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKA--QNWKNVPPMTTCRVK--------VKSSKMISNKLPATII-AYGNHCKEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKTTPDYIKNSK 1954
            ++W+   +  V V   L +LC V  V     Y  EWA +I  G   A+ +A +  ++YLG IG+L+N + FR ++    R +RS    T+ L+   ++S    Q    R KR +                 R+    +FNDP W  +WYL D+R +      D+ + PVW   ITGKGV + +LDDGLE  H D+  NYDP +S D NDND+DP P       N HGTRCA EIAM ANN  CGVG+AYN K+GGIRMLDG V    EA S+GFN  H+ IYS+SWGP DDGKT+E P +L Q+    G   GRNGKG+IFVWASGNGG   D+C CDGY  S+Y IS++S +     P++AEKC ST+   YS+   +   +I+AD+  +CT+ H+GTSASAP AAGIFAL LE NP+LTWRD++HL+ WTSEY+ + +N GWKKN AG  VN++FGFGLLNA  +V  A  + WK V     C V+        ++S   ++ ++P        NH K     +E + +   I Y  RG L I L SP G NT LLT R  D S  G  +W F SVH WGE+P G W + + D ++  +   G +    L  +GT T P+++K+ +
Sbjct:    4 RYWYPVCIASVAV---LSLLCQVLAVGVDKRYVNEWAAEIPGGPEEAQLLALELDYDYLGQIGSLENHYLFRHKAHPR-RSRRSAPHLTKRLADDGRVSWAEQQYSKERNKRST----------------FRQDTKNLFNDPLWNRQWYLQDTRSNPSLPKLDLHLLPVWKKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDNDPFPRYDITNENRHGTRCAGEIAMVANNNKCGVGVAYNAKVGGIRMLDGVVTDAKEASSIGFNPQHVHIYSASWGPNDDGKTVEGPGRLAQKAFEYGIKQGRNGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATAYSSGDYTDQRIISADLHNECTETHTGTSASAPLAAGIFALALEFNPDLTWRDMQHLVVWTSEYDPLANNAGWKKNGAGLMVNSRFGFGLLNAKALVDLADPKTWKGVAEKKECIVEDNEFSPRFLRSDGEVTIQIPTKACEGQDNHIKS----LEHLQLEATIEYTRRGDLHITLTSPLGTNTVLLTERERDTSPYGFKSWDFMSVHTWGEDPAGTWTLKISD-VSGRKKNEGRIVSWKLILHGTSTQPEHMKHPR 606          

Query:  107 KHWFLNKMNDVQVFRNLLILCVFLVL-TQAEYQWEWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKA--QNWKNVPPMTTCRVK--------VKSSKMISNKLPATII-AYGNHCKEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKTTPDYIKNSK 1954
            ++W+   +  V V   L +LC  L       Y  EWA +I  G   A+ +A +  ++YLG IG+L+N + FR ++    R +RS    T+ L+   ++S    Q    R KR +                 R+    +FNDP W  +WYL D+R +      D+ + PVW   ITGKGV + +LDDGLE  H D+  NYDP +S D NDND+DP P       N HGTRCA EIAM ANN  CGVG+AYN K+GGIRMLDG V    EA S+GFN  H+ IYS+SWGP DDGKT+E P +L Q+    G   GRNGKG+IFVWASGNGG   D+C CDGY  S+Y IS++S +     P++AEKC ST+   YS+   +   +I+AD+  +CT+ H+GTSASAP AAGIFAL LE NP+LTWRD++HL+ WTSEY+ + +N GWKKN AG  VN++FGFGLLNA  +V  A  + WK V     C V+        ++S   ++ ++P        NH K     +E + +   I Y  RG L I L SP G NT LLT R  D S  G  +W F SVH WGE+P G W + + D ++  +   G +    L  +GT T P+++K+ +
Sbjct:    4 RYWYPMCIASVAV---LSLLCQVLAAGVDKRYMNEWAAEIPGGPEEAQLLALELDYDYLGQIGSLENHYLFRHKAHPR-RSRRSAPHLTKRLADDGRVSWAEQQYSKERNKRST----------------FRQDTKNLFNDPLWNRQWYLQDTRSNPSLPKLDLHLLPVWKKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDNDPFPRYDITNENRHGTRCAGEIAMVANNNKCGVGVAYNAKVGGIRMLDGVVTDAKEASSIGFNPQHVHIYSASWGPNDDGKTVEGPGRLAQKAFEYGIKQGRNGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATAYSSGDYTDQRIISADLHNECTETHTGTSASAPLAAGIFALALEFNPDLTWRDMQHLVVWTSEYDPLANNAGWKKNGAGLMVNSRFGFGLLNAKALVDLADPKTWKGVAEKKECIVEDNEFSPRFLRSDGEVTIQIPTKACEGQDNHIKS----LEHLQLEATIEYTRRGDLHITLTSPLGTNTVLLTERERDTSPYGFKSWDFMSVHTWGEDPAGTWTLKISD-VSGRKKNEGRIVSWKLILHGTSTQPEHMKHPR 606          

Query:  107 KHWFLNKMNDVQVFRNLLILCVFLVL-TQAEYQWEWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKA--QNWKNVPPMTTCRVK--------VKSSKMISNKLPATII-AYGNHCKEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKTTPDYIKNSK 1954
            ++W+   +  V V   L +LC  L       Y  EWA +I  G   A+ +A +  ++YLG IG+L+N + FR ++    R +RS    T+ L+   ++S    Q    R KR +                 R+    +FNDP W  +WYL D+R +      D+ + PVW   ITGKGV + +LDDGLE  H D+  NYDP +S D NDND+DP P       N HGTRCA EIAM ANN  CGVG+AYN K+GGIRMLDG V    EA S+GFN  H+ IYS+SWGP DDGKT+E P +L Q+    G   GRNGKG+IFVWASGNGG   D+C CDGY  S+Y IS++S +     P++AEKC ST+   YS+   +   +I+AD+  +CT+ H+GTSASAP AAGIFAL LE NP+LTWRD++HL+ WTSEY+ + +N GWKKN AG  VN++FGFGLLNA  +V  A  + WK V     C V+        ++S   ++ ++P        NH K     +E + +   I Y  RG L I L SP G NT LLT R  D S  G  +W F SVH WGE+P G W + + D ++  +   G +    L  +GT T P+++K+ +
Sbjct:    4 RYWYPMCIASVAV---LSLLCQVLAAGVDKRYMNEWAAEIPGGPEEAQLLALELDYDYLGQIGSLENHYLFRHKAHPR-RSRRSAPHLTKRLADDGRVSWAEQQYSKERNKRST----------------FRQDTKNLFNDPLWNRQWYLQDTRSNPSLPKLDLHLLPVWKKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDNDPFPRYDITNENRHGTRCAGEIAMVANNNKCGVGVAYNAKVGGIRMLDGVVTDAKEASSIGFNPQHVHIYSASWGPNDDGKTVEGPGRLAQKAFEYGIKQGRNGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATAYSSGDYTDQRIISADLHNECTETHTGTSASAPLAAGIFALALEFNPDLTWRDMQHLVVWTSEYDPLANNAGWKKNGAGLMVNSRFGFGLLNAKALVDLADPKTWKGVAEKKECIVEDNEFSPRFLRSDGEVTIQIPTKACEGQDNHIKS----LEHLQLEATIEYTRRGDLHITLTSPLGTNTVLLTERERDTSPYGFKSWDFMSVHTWGEDPAGTWTLKISD-VSGRKKNEGRIVSWKLILHGTSTQPEHMKHPR 606          

Query:  209 WAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRN---LSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTC-----RVKVKSSKMI--SNKLPATIIAYGNHCKEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKIND--DEDRSGEVTDCTLEFYGTKTTP-DYIKNSKTRRRNYD 1975
            WAV+I  G   A E+A  +G+  LG IGNL+N +HF    +     KRS  ++      L  H K+  +  Q +  R KR  +   ++++                FNDP WP+ WYL  S   S  +S +M V   W    TGK V V+ILDDG+E  HPDLI NYDP +S D+N +D DPSP       N+HGTRCA E+A SANN  C VGIAYN +IGGIRMLDG V  ++EAKSLG   ++IDIYSSSWGP DDGKT++ P  L ++    G   GR G G+IFVWASGNGG   D CSCDGY +S+Y IS++S T++   P++ E+C ST+  TYS+ +  +  ++  D++  CT  H+GTS SAP  AG+ AL LE NP L WRD++HL+  TS    ++    WK N AG  V+  +GFGL++A  MV +A+ W+ VPP   C     R  +++ ++I  + +  A +   G++    VA++E +++ + I++  RG L I L SP G  + LL  R  D S +G  NW F +VH WGE   G+W + + D  +   + +  G++ + TL FYGT   P ++I    +R R  D
Sbjct:   29 WAVRIPGGPEVAAELAAQYGYLSLGQIGNLENYYHFYHSRT----IKRSTYASRGTHSFLRMHPKVEWMQQQEVKKRVKRHVRTDPNLVN----------------FNDPIWPNMWYLHCSDKSSRCRS-EMNVMSAWQRGYTGKNVVVSILDDGVEKNHPDLIQNYDPHASHDVNGDDQDPSPRYDASNENKHGTRCAGEVAASANNSHCIVGIAYNARIGGIRMLDGDVTDVVEAKSLGVRPDYIDIYSSSWGPDDDGKTVDGPGPLARKAFEDGIKKGRKGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISISSTTENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQGCTDDHTGTSVSAPMVAGVIALALEANPVLNWRDVQHLLVKTSRSVHLRAP-DWKTNGAGRKVSHLYGFGLVDADAMVVEAKKWRTVPPQHVCIGASDRRFIRAVQLIRTTTQTNACVDNAGHY----VAYLEHVVVRVTISHPRRGDLQIYLISPSGTKSQLLAKRTFDSSNEGFKNWEFMTVHCWGEKAEGEWTLEIHDSSSQLRNPEIQGKLKEWTLIFYGTSEHPYNHIGTQHSRIRTLD 604          

Query:  209 WAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRN---LSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTC-RVKVKSSKMISNKLPATIIAYGNHCKEK----VAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKIND--DEDRSGEVTDCTLEFYGTKTTP-DYIKNSKTRRRNYD 1975
            WAV+I  G   A E+A  +G+  LG IGNL+N +HF    +     KRS  ++      L  H K+  +  Q +  R KR  +   ++++                FNDP WP+ WYL  S   S  +S +M V   W    TGK V V+ILDDG+E  HPDLI NYDP +S D+N +D DPSP       N+HGTRCA E+A SANN  C VGIAYN +IGGIRMLDG V  ++EAKSLG   ++IDIYSSSWGP DDGKT++ P  L ++    G   GR G G+IFVWASGNGG   D CSCDGY +S+Y IS++S T++   P++ E+C ST+  TYS+ +  +  ++  D++  CT  H+GTS SAP  AG+ AL LE NP L WRD++HL+  TS    ++    WK N AG  V+  +GFGL++A  MV +A+ W+ VPP   C     +  + I            N C +     VA++E +++ + I++  RG L I L SP G  + LL  R  D S +G  NW F +VH WGE   G+W + + D  +   + +  G++ + TL FYGT   P ++I    +R R  D
Sbjct:   38 WAVRIPGGPEVAAELAAQYGYLSLGQIGNLENYYHFYHSRT----IKRSTYASRGTHSFLRMHPKVEWMQQQEVKKRVKRHVRTDPNLVN----------------FNDPIWPNMWYLHCSDKSSRCRS-EMNVMSAWQRGYTGKNVVVSILDDGVEKNHPDLIQNYDPHASHDVNGDDQDPSPRYDASNENKHGTRCAGEVAASANNSHCIVGIAYNARIGGIRMLDGDVTDVVEAKSLGVRPDYIDIYSSSWGPDDDGKTVDGPGPLARKAFEDGIKKGRKGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISISSTTENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQGCTDDHTGTSVSAPMVAGVIALALEANPVLNWRDVQHLLVKTSRSVHLRAP-DWKTNGAGRKVSHLYGFGLVDADAMVVEAKKWRTVPPQHVCIGASDRRPRFIRAVQLIRTTTQTNACVDNAGHYVAYLEHVVVRVTISHPRRGDLQIYLISPSGTKSQLLAKRTFDSSNEGFKNWEFMTVHCWGEKAEGEWTLEIHDSSSQLRNPEIQGKLKEWTLIFYGTSEHPYNHIGTQHSRIRTLD 615          

Query:  161 ILCVFLVL--TQAEYQW--EWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKA--QNWKNVPPMTTCRVKVKSSKMISNKLPATIIAY--GNHCKEK---VAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKTTPDYIKNSK 1954
              CV+  L   +A+ Q+  EWA +I  G+ AA  IA++ G++ LG IG+L+N + F+ +S    R +RS    T+ LS   +++    Q    R KR  +                +   L++FNDP W  +WYL D+R  +     D+ V PVW   ITGKGV + +LDDGLE  H D+  NYDP +S D NDND DP P       N+HGTRCA EIAM ANN  CGVG+AYN K+GGIRMLDG V   IEA S+GFN  H+DIYS+SWGP DDGKT+E P +L Q+    G   GR GKG+IFVWASGNGG   D+C CDGY  S+Y IS++S +     P++AEKC ST+  +YS+   +   + +AD+   CT+ H+GTSASAP AAGIFAL LE NPNLTWRD++HL+ WTSEY+ +  N GWKKN AG  VN++FGFGLLNA  +V  A  + W+NVP    C VK  + +  + K    +I       C+ +   +  +E +     I Y  RG L + L S  G +T LL  R  D S +G  NW F SVH WGENP G W + + D ++      G + +  L  +GT + P+++K  +
Sbjct:   15 FFCVWCALNSVKAKRQFVNEWAAEIPGGQEAASAIAEELGYDLLGQIGSLENHYLFKHKSHPR-RSRRSALHITKRLSDDDRVTWAEQQYEKERSKRSVQ----------------KDSALDLFNDPMWNQQWYLQDTRMTAALPKLDLHVIPVWEKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFPRYDLTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATSYSSGDYTDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPLASNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPRTWRNVPEKKECVVKDNNFEPRALKANGEVIVEIPTRACEGQENAIKSLEHVQFEATIEYSRRGDLHVTLTSAVGTSTVLLAERERDTSPNGFKNWDFMSVHTWGENPVGTWTLKITD-MSGRMQNEGRIVNWKLILHGTSSQPEHMKQPR 605          

Query:  134 DVQVFRNLLILCVFLVLTQAEYQWEWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRN---LSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTCRVKV-KSSKMISNKLPATIIAYGNHCKEK----VAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDED--RSGEVTDCTLEFYGTKTTPDYIKNS--KTRRRNYDETMD 1987
            D+     LL  C+  V     Y   WAVKI  G   A  IA  +GF  +G IG L + +HF    +     KRSV S+      +S   K+  +  Q +  R KRD               L H +     FNDPKWP  WY+  S      +S DM +   W    TGK + V ILDDG+E THPDL+ NYD  +S D+N ND DP P       N+HGTRCA E+A +ANN  C VGIA+N KIGG+RMLDG V  ++EAKS+ +N  H+ IYS+SWGP DDGKT++ P+ L ++    G   GR G G++FVWASGNGG  +D CSCDGY +S+Y IS++S  +  K P++ E+C ST+  TYS+       +I  D++ +CT  H+GTSASAP AAGI AL LE NP LTWRD++H+I  TS    +  N  WK NAAGF V+  +GFGL++A  MV +A+ W  VP    C     +  K I        I   + C +     V ++E +++ + IT+  RG L I L SP G  + LL  R  D S +G  NW F ++H WGE   G WV+ V D  +   +    G++ + +L  YGT   P    N   K  R  Y    D
Sbjct:   16 DLLCVLALLAGCLLPVCRTRVYTNHWAVKIAGGFAEADRIASKYGFINVGQIGALKDYYHFYHSRT----IKRSVLSSRGTHSFISMEPKVEWIQQQVVKKRTKRDYD-------------LSHAQSTY--FNDPKWPSMWYMHCSDNTHPCQS-DMNIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAATANNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSYNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNAN-DWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPQQHVCVESTDRQIKTIRPNSAVRSIYKASGCSDNPNHHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPYSPTNEFPKVERFRYSRVED 624          

Query:  209 WAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTCRVKVK------SSKMISNKLPATIIAYGNHCKEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTK----TTPDYIKNSKT 1957
            WAV I  G   A  +A   GF  LG I    + +HF         + R+V          +K S+  H+    R +R+ ++    +   + KR + +R V +   DPK+P +WYL      S     D+ V   W    TG G+ V+ILDDG+E  HPDL  NYDP +S D+ND D DP P  T    N HGTRCA E+A  ANN +CGVG+AYN +IGG+RMLDG V   +EA+SLG N NHI IYS+SWGP DDGKT++ P++L +E   RG   GR G G+IFVWASGNGG   DSC+CDGY +S+Y +S++S T     P+++E C ST+  TYS+ ++++  ++  D++ KCT+ H+GTSASAP AAGI AL LE N NLTWRD++HL+  TS+   +  +  W  N  G  V+  +G+GLL+A  MV  AQNW  V P   C V++         ++   K     +   NH    +  +E +   + ++Y  RG L I L SP G  +TLL  R  D S DG  +W F + H+W E+P G+WV+ +E+    + +  G +T  TL  YGT     +TP      KT
Sbjct:   34 WAVHIPGGPAVADRVAQKHGFHNLGQI--FGDYYHF---------WHRAV----------TKRSLSPHRPRHSRLQREPQVK--WLEQQVAKR-RAKRDVYQEPTDPKFPQQWYL------SGVTQRDLNVKEAWAQGFTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNAD-DWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIVEILVEPKDIGKRLEVRKAVTACLGEPNH----ITRLEHVQARLTLSYNRRGDLAIHLISPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPAGEWVLEIEN--TSEANNYGTLTKFTLVLYGTAPEGLSTPPESSGCKT 589          

Query:  209 WAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTCRVKVK------SSKMISNKLPATIIAYGNHCKEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTK----TTPDYIKNSKT 1957
            WAV I  G   A  +A   GF  LG I    + +HF         + R+V          +K S+  H+    R +R+ ++    +   + KR + +R V +   DPK+P +WYL      S     D+ V   W    TG G+ V+ILDDG+E  HPDL  NYDP +S D+ND D DP P  T    N HGTRCA E+A  ANN +CGVG+AYN +IGG+RMLDG V   +EA+SLG N NHI IYS+SWGP DDGKT++ P++L +E   RG   GR G G+IFVWASGNGG   DSC+CDGY +S+Y +S++S T     P+++E C ST+  TYS+ ++++  ++  D++ KCT+ H+GTSASAP AAGI AL LE N NLTWRD++HL+  TS+   +  +  W  N  G  V+  +G+GLL+A  MV  AQNW  V P   C V++         ++   K     +   NH    +  +E +   + ++Y  RG L I L SP G  +TLL  R  D S DG  +W F + H+W E+P G+WV+ +E+    + +  G +T  TL  YGT     +TP      KT
Sbjct:   34 WAVHIPGGPAVADRVAQKHGFHNLGQI--FGDYYHF---------WHRAV----------TKRSLSPHRPRHSRLQREPQVK--WLEQQVAKR-RAKRDVYQEPTDPKFPQQWYL------SGVTQRDLNVKEAWAQGFTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNAD-DWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIVEILVEPKDIGKRLEVRKAVTACLGEPNH----ITRLEHVQARLTLSYNRRGDLAIHLISPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPAGEWVLEIEN--TSEANNYGTLTKFTLVLYGTAPEGLSTPPESSGCKT 589          

Query:  209 WAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTCRVKVK------SSKMISNKLPATIIAYGNHCKEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTK----TTPDYIKNSKT 1957
            WAV I  G   A  +A   GF  LG I    + +HF         + R+V          +K S+  H+    R +R+ ++    +   + KR + +R V +   DPK+P +WYL      S     D+ V   W    TG G+ V+ILDDG+E  HPDL  NYDP +S D+ND D DP P  T    N HGTRCA E+A  ANN +CGVG+AYN +IGG+RMLDG V   +EA+SLG N NHI IYS+SWGP DDGKT++ P++L +E   RG   GR G G+IFVWASGNGG   DSC+CDGY +S+Y +S++S T     P+++E C ST+  TYS+ ++++  ++  D++ KCT+ H+GTSASAP AAGI AL LE N NLTWRD++HL+  TS+   +  +  W  N  G  V+  +G+GLL+A  MV  AQNW  V P   C V++         ++   K     +   NH    +  +E +   + ++Y  RG L I L SP G  +TLL  R  D S DG  +W F + H+W E+P G+WV+ +E+    + +  G +T  TL  YGT     +TP      KT
Sbjct:   34 WAVHIPGGPAVADRVAQKHGFHNLGQI--FGDYYHF---------WHRAV----------TKRSLSPHRPRHSRLQREPQVK--WLEQQVAKR-RAKRDVYQEPTDPKFPQQWYL------SGVTQRDLNVKEAWAQGFTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNAD-DWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIVEILVEPKDIGKRLEVRKAVTACLGEPNH----ITRLEHVQARLTLSYNRRGDLAIHLISPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPAGEWVLEIEN--TSEANNYGTLTKFTLVLYGTAPEGLSTPPESSGCKT 589          

Query:  161 ILCVFLVLT--QAEYQW--EWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKA--QNWKNVPPMTTCRVKVKSSKMISNKLPATIIAY--GNHCKEK---VAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKTTPDYIKNSK 1954
              CV+  L+  +A+ Q+  EWA +I  G+ AA  IA++ G++ LG IG+L+N + F+ +S    R +RS    T+ LS   +++    Q    R KR  +                +   L++FNDP W  +WYL D+R  +     D+ V PVW   ITGKGV + +LDDGLE  H D+  NYDP +S D NDND DP P       N+HGTRCA EIAM ANN  CGVG+AYN K+GGIRMLDG V   IEA S+GFN  H+DIYS+SWGP DDGKT+E P +L Q+    G   GR GKG+IFVWASGNGG   D+C CDGY  S+Y IS++S +     P++AEKC ST+  +YS+   +   + +AD+   CT+ H+GTSASAP AAGIFAL LE NPNLTWRD++HL+ WTSEY+ +  N GWKKN AG  VN++FGFGLLNA  +V  A  + W+NVP    C VK  + +  + K    +I       C+ +   +  +E +     I Y  RG L + L S  G +T LL  R  D S +G  NW F SVH WGENP G W + + D ++      G + +  L  +GT + P+++K  +
Sbjct:   15 FFCVWCALSSVKAKRQFVNEWAAEIPGGQEAASAIAEELGYDLLGQIGSLENHYLFKHKSHPR-RSRRSALHITKRLSDDDRVTWAEQQYEKERSKRSVQ----------------KDSALDLFNDPMWNQQWYLQDTRMTAALPKLDLHVIPVWEKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFPRYDLTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATSYSSGDYTDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPLASNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPRTWRNVPEKKECVVKDNNFEPRALKANGEVIVEIPTRACEGQENAIKSLEHVQFEATIEYSRRGDLHVTLTSAVGTSTVLLAERERDTSPNGFKNWDFMSVHTWGENPVGTWTLKITD-MSGRMQNEGRIVNWKLILHGTSSQPEHMKQPR 605          

Query:  161 ILCVFLVL--TQAEYQW--EWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKA--QNWKNVPPMTTCRVKVKSSKMISNKLPATIIAY--GNHCKEK---VAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKTTPDYIKNSK 1954
              CV+  L   +A+ Q+  EWA +I  G+ AA  IA++ G++ LG IG+L+N + F+ +S    R +RS    T+ LS   +++    Q    R KR  +                +   L++FNDP W  +WYL D+R  +     D+ V PVW   ITGKGV + +LDDGLE  H D+  NYDP +S D NDND DP P       N+HGTRCA EIAM ANN  CGVG+AYN K+GGIRMLDG V   IEA S+GFN  H+DIYS+SWGP DDGKT+E P +L Q+    G   GR GKG+IFVWASGNGG   D+C CDGY  S+Y IS++S +     P++AEKC ST+  +YS+   +   + +AD+   CT+ H+GTSASAP AAGIFAL LE NPNLTWRD++HL+ WTSEY+ +  N GWKKN AG  VN++FGFGLLNA  +V  A  + W+NVP    C VK  + +  + K    +I       C+ +   +  +E +     I Y  RG L + L S  G +T LL  R  D S +G  NW F SVH WGENP G W + + D ++      G + +  L  +GT + P+++K  +
Sbjct:   15 FFCVWCALNSVKAKRQFVNEWAAEIPGGQEAASAIAEELGYDLLGQIGSLENHYLFKHKSHPR-RSRRSALHITKRLSDDDRVTWAEQQYEKERSKRSVQ----------------KDSALDLFNDPMWNQQWYLQDTRMTAALPKLDLHVIPVWEKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFPRYDLTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATSYSSGDYTDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPLASNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPRTWRNVPEKKECVVKDNNFEPRALKANGEVIVEIPTRACEGQENAIKSLEHVQFEATIEYSRRGDLHVTLTSAVGTSTVLLAERERDTSPNGFKNWDFMSVHTWGENPVGTWTLKITD-MSGRMQNEGRIVNWKLILHGTSSQPEHMKQPR 605          

Query:  155 LLILCVFLVL--TQAEYQW--EWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKA--QNWKNVPPMTTCRVKVKSSKMISNKLPATIIAY--GNHCKEK---VAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKTTPDYIKNSK 1954
              + CV+  L   +A+ Q+  EWA +I  G  AA  IA++ G++ LG IG+L+N + F+ ++    R +RS    T+ LS   ++     Q    R+KR                   R   L +FNDP W  +WYL D+R  +     D+ V PVW   ITGKGV + +LDDGLE  H D+  NYDP +S D NDND DP P   P   N+HGTRCA EIAM ANN  CGVG+AYN K+GGIRMLDG V   IEA S+GFN  H+DIYS+SWGP DDGKT+E P +L Q+    G   GR GKG+IFVWASGNGG   D+C CDGY  S+Y IS++S +     P++AEKC ST+  +YS+   +   + +AD+   CT+ H+GTSASAP AAGIFAL LE NPNLTWRD++HL+ WTSEY+ + +N GWKKN AG  VN++FGFGLLNA  +V  A  + W+NVP    C +K  + +  + K    +I       C+ +   +  +E +     I Y  RG L + L S  G +T LL  R  D S +G  NW F SVH WGENP G W + V D ++      G + +  L  +GT + P+++K  +
Sbjct:   13 FTLFCVWCALNSVKAKRQFVNEWAAEIHGGPEAASAIAEELGYDLLGQIGSLENHYLFKHKNHPR-RSRRSALHITKRLSDDDRVIWAEQQYEKERRKRSVP----------------RDSALNLFNDPMWNQQWYLQDTRMTASLPKLDLHVIPVWQKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFPRYDPTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATSYSSGDYTDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPLANNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPRTWRNVPEKKECIIKDNNFEPRALKANGEVIVEIPTRACEGQENAINSLEHVQFEATIEYSRRGDLHVTLTSAAGTSTVLLAERERDTSPNGFKNWDFMSVHTWGENPVGTWTLKVTD-MSGRMQNEGRIVNWKLILHGTSSQPEHMKQPR 605          

Query:  155 LLILCVFLVLTQA----EYQWEWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKA--QNWKNVPPMTTCRVK--------VKSSKMISNKLPATIIAYGNHCKEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKTTPDYIKNSK 1954
             ++ C +  L  A    ++  EWA +I  G  AA  IA++ G++ LG IG+L+N + F+ ++    R +RS    T+ LS   ++     Q    R KR +                 R   L +FNDP W  +WYL D+R  +     D+ V PVW   ITGKGV + +LDDGLE  H D+  NYDP +S D NDND DP P   P   N+HGTRCA EIAM ANN  CGVG+AYN K+GGIRMLDG V   IEA S+GFN  H+DIYS+SWGP DDGKT+E P +L Q+    G   GR GKG+IFVWASGNGG   D+C CDGY  S+Y IS++S +     P++AEKC ST+  +YS+   +   + +AD+   CT+ H+GTSASAP AAGIFAL LE NPNLTWRD++HL+ WTSEY+ + +N GWKKN AG  VN++FGFGLLNA  +V  A  + W++VP    C VK        +K++  +  ++P T    G   +  +  +E +     I Y  RG L + L S  G +T LL  R  D S +G  NW F SVH WGENP G W + + D ++      G + +  L  +GT + P+++K  +
Sbjct:   13 FVLFCAWCALNSAKAKRQFVNEWAAEIPGGPEAASAIAEELGYDLLGQIGSLENHYLFKHKNHPR-RSRRSAFHITKRLSDDDRVIWAEQQYEKERSKRSAL----------------RDSALNLFNDPMWNQQWYLQDTRMTAALPKLDLHVIPVWQKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFPRYDPTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATSYSSGDYTDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPLANNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPRTWRSVPEKKECVVKDNDFEPRALKANGEVIIEIP-TRACEGQ--ENAIKSLEHVQFEATIEYSRRGDLHVTLTSAAGTSTVLLAERERDTSPNGFKNWDFMSVHTWGENPIGTWTLRITD-MSGRIQNEGRIVNWKLILHGTSSQPEHMKQPR 605          

Query:  161 ILCVFLVL--TQAEYQW--EWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKA--QNWKNVPPMTTCRVK--------VKSSKMISNKLPATIIAYGNHCKEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKTTPDYIKNSK 1954
            + C +  +   +A+ Q+  EWA +I  G  AA  IA + G++ LG IG+L+N + F+  +    R +RS    T+ LS   ++     Q    R KR           +++     R   L++FNDP W  +WYL D+R  +     D+ V PVW   ITGKGV + +LDDGLE  H D+  NYDP +S D NDND DP P       N+HGTRCA EIAM ANN  CGVG+AYN K+GGIRMLDG V   IEA  +GFN  H+DIYS+SWGP DDGKT+E P +L Q+    G   GR GKG+IFVWASGNGG   D+C CDGY  S+Y IS+NS +     P++AEKC ST+  +YS+   +   + +AD+   CT+ H+GTSASAP AAGIFAL LE NPNLTWRD++HL+ WTSEY+ + +N GWKKN AG  VN++FGFGLLNA  +V  A    W +VP    C VK        +K++  +  ++P T    G   +  +  +E +     I Y  RG L + L S  G +T LL  R  D S +G  NW F SVH WGENP G W + + D ++      G +    L  +GT + P+++K  +
Sbjct:   15 LFCAWCAMNSVKAKKQFVNEWAAEIPGGPEAASAIAQELGYDLLGQIGSLENHYLFKHRNHPR-RSRRSALHITKRLSDDDRVIWAEQQYEKERSKR-----------SVL-----RDSALDLFNDPMWNQQWYLQDTRMTATLPKLDLHVIPVWQKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFPRYDLINENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRMLDGIVTDAIEASLIGFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISINSASQQGLSPWYAEKCSSTLATSYSSGDYTDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPLANNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPSTWSSVPEKKECVVKDNDFEPRALKANGEVIIEIP-TRACEGQ--ENAIKSLEHVQFEATIEYSRRGDLHVTLTSAAGTSTVLLAERERDTSPNGFKNWDFMSVHTWGENPIGTWTLRIAD-MSGRIQNEGRIVTWKLILHGTSSQPEHMKQPR 605          

Query:  155 LLILCVFLVLTQAEYQWEWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEM-FNDPKWPDEWYLFDSRF-DSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKA--QNWKNVPPMTTCRVKVKSSKMISNKLPA----TIIAYGNHCK---EKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKTTPDYIKNSKTRR 1963
            L +L V  V     Y  EWAV+I  G    + +    G++ +  +   DN +     S    R KRS +  TR L   +++     Q    R KRD             KR+   R  + + FNDP WP +WY+ D    D  +  YD+ + PVW   ITGKGV +++LDDG+EH HPDL  NYDP +STDLN NDDDP P   P   N+HGTRCA EIAM ANN +CGVG+AYN +IGG+RMLDG V   +E +++ FN+ +IDIYS+SWGP DDG T+E P K+ Q     G   GRNGKG I+VWASGNGG   D+C CDGY  S+Y +S++S +     P++AEKC STM  TYS+       + +AD+ G CT +H+GTSA+AP AAGIFALVLE NP+LTWRD++HL+AWTSEY+ +++N GWK+N AG+WVN  FGFGLLNA  +V++A  Q WK VP    C V   S+  +  +L +     I    + C+    ++ ++E + + +N+ Y  RGAL I L SP G  T LL+ R++D S  G  NW F SV +WGENPTG+W + ++DK   D    G V   TL  +GTK  PD+ + +  RR
Sbjct:   12 LFVLYVCNVTAGNHYLNEWAVEIPGGYDEVQRVTRLHGYDLVKELKPFDNHY-LLTHSEVPSRSKRSADHHTRRLQTDNRVHWAEQQVTKTRTKRDL----------FEKRVDEERSYIRLDFNDPLWPKQWYMKDGEVHDPTELRYDLHIIPVWNKGITGKGVVISVLDDGIEHNHPDLAQNYDPRASTDLNGNDDDPQPRYDPTNENKHGTRCAGEIAMVANNSLCGVGVAYNARIGGVRMLDGRVTDSLEGQAIAFNHKYIDIYSASWGPNDDGATVEGPGKMAQRAFELGIKEGRNGKGVIYVWASGNGGRLGDNCDCDGYTGSIYSLSISSASQHQMTPWYAEKCASTMATTYSSGEYGDDRVASADLHGGCTVQHTGTSAAAPLAAGIFALVLEANPDLTWRDMQHLVAWTSEYSSLRNNSGWKQNGAGYWVNNAFGFGLLNAASLVQEAHPQTWKTVPEKYVCTVHSNSNSNLPQRLQSGYKLDIDLTSSGCQGQDNEIRYLEHVQMQINMDYSKRGALHISLTSPSGNETMLLSERSMDGSTAGFQNWTFMSVQSWGENPTGQWKLTIKDKKRGDN--HGVVKGVTLILHGTKEMPDHRQRAGGRR 612          

Query:  158 LILCVFLVLTQAEY----QWEWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRF-KRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHR---RKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTCRVKVKSSKMISNKL--PATIIAYGNHCK---EKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKTTPDYIK-NSKTRRRNYD 1975
             + C  L L  + +      E  V+   G    KE+AD+ G+ + G +    + +     + KN  + KR   +  R+L +  ++  +  Q++  RQKRD +  D  +   + K    R   R     FND  W  +WYL D+R  SD    D+ V PV+ M ITGKG++V ILDDG+E+TH DL  NYDP  S D N++DDDP P      +N HGTRCA EIAM ANN  CGVGIA+N K+GG+++LDGP+N  IE  +L +  N +DIYS+SWGP DDG+T++ P +L  E L  G   GRNGKG I+VWASGNGG   D+C+CDGY++S+Y IS+ S +   +FP++ E C ST+  TYS+ +     +   D+  +CT KH+GTSASAP AAGI AL LE NPNLTWRD++HLI WTSE   + +N GW++NAAGFW N +FGFGL+NAY MV  A NW +VP  + C  K+   K  S     P T+    + CK    ++ F+E + + M+I+Y IRGAL + L SP G N  LLT R+ D++  G   W F SV  WGENP G W + + DKI      SGEVTD T+  +GTK  P+Y+   S+   R Y+
Sbjct:    3 FLACFLLFLAPSIFANFHNEEVVVRAVGGLEMVKELADEAGYIFKGPVRGFKDTYVILPRNDKNSEYDKRDGNNVRRSLEEDKRVIWIEKQKVKPRQKRDYRYLDDFLESLVEKDEFQRIKSRNSERAFNDELWSQQWYLQDTRTRSDLPKLDLNVIPVYRMGITGKGIRVNILDDGIEYTHDDLKINYDPEISYDCNEDDDDPLPRYDRTRANSHGTRCAGEIAMVANNLKCGVGIAFNAKVGGVKILDGPINDRIEGTALSYGLNLVDIYSASWGPSDDGETVDGPGRLASEALENGVKKGRNGKGAIYVWASGNGGSQHDNCNCDGYLTSIYTISIGSASQKGEFPWYGEACASTLAVTYSSGAYRDQMIATTDLFNQCTIKHTGTSASAPLAAGIIALALEANPNLTWRDVQHLIVWTSEPAPVYENPGWQQNAAGFWFNTRFGFGLMNAYGMVIAALNWTSVPEKSVCTYKISLPKNGSFSFGNPITVPFDSDGCKGSINEIQFLEHVEVQMSISYNIRGALELNLTSPSGTNVQLLTPRDHDQNPFGFHEWTFMSVMTWGENPNGLWKIVLSDKIG-PYGNSGEVTDVTVRLHGTKHRPNYMSAGSRNYNREYN 621          

Query:  185 TQAEYQWEWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRK----------VLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTCRVKVKSSK--MISNKLPATIIAYGNHC---KEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKTTPDYIKNSKTRRRNYD 1975
            T   Y  EW V++E G   A+ +A   G+++LG +    + +   K      + KR+    T+ L++ +++     Q    R KRD +     +  + I R   RRK          V  +FND  W  EWYL D+R   D    D+ V P++ M +TG+GV+V +LDDGLE+TH D+ +NYDP  S D NDND DP+P      +N HGTRCA EIAMSANN+ CGVG+A+N K+GG+R+LDG VN  +E  +LG+  + +DIYS+SWGP DDGKT+E P +L QE + RG   GR GKG+IFVWASGNGG   D+C+CDGY+ S+Y +S+ S +   +FP++ E+C +TM ATYS+ + S   +   D++  CT KH+GTSASAP AAGI AL LE+NP LTWRD++HL+ WT+EY  + DN GW++NAAG W+N +FGFGL+NA+ +V  A NW NVPP T C    +  K   IS+ + + I+   + C   KE++ F+E + ++ NI + +RGAL + L SP G    LL+ R  D+S  G + W F SV +WGE P GKWV+ + D++  + +R G +   TL  +GTK  P Y+ N   RR N D
Sbjct:   24 TTQHYSNEWMVRLEGGPDVAQLLAVQLGYDFLGSVTGFPDTYRMLKLDHPPLQ-KRAFPRLTQRLARDARVVWAEQQFAKQRVKRDFEPP---LDVSDIPRPTSRRKRADLEVPSQRVERLFNDELWDQEWYLQDTRTRPDLPKLDLHVLPLYKMGVTGRGVRVVVLDDGLEYTHDDIRENYDPEISYDANDNDYDPTPRYDEALTNAHGTRCAGEIAMSANNRKCGVGVAFNAKVGGVRLLDGMVNDRVEGSALGYAFDKVDIYSASWGPNDDGKTVEGPGRLAQEAIERGIQQGRGGKGSIFVWASGNGGSKGDNCNCDGYIGSVYTLSIGSASQQGQFPWYGERCAATMAATYSSGAYSDQMIATTDLRNTCTIKHTGTSASAPLAAGIIALALEVNPELTWRDVQHLVMWTAEYAPLSDNTGWQRNAAGAWINTRFGFGLMNAHGLVTAATNWTNVPPKTICTAAAEPLKNNTISHGIRSEILFITDGCEGKKEEIRFLEHVEVVTNIAFTVRGALEMHLTSPAGTRVQLLSPRERDQSDKGFVGWKFLSVLSWGEQPRGKWVLDIIDQVGPESNR-GHLGSFTLVLHGTKERPAYLDNGP-RRYNQD 629          

Query:  155 LLILCVFLVLTQAEYQW--EWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKA--QNWKNVPPMTTCRVKVKS--SKMISNKLPATIIAYGNHCKEK---VAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKTTPDYIKNSK 1954
            LL  C       AE Q+  EWA ++  G  AA+ IA++  ++ +G IG+L N + FR +S    R +RS    T+ LS   ++S    Q    R KR + +TD                   +FNDP W  +WYL D+R        D+ V PVW   ITGKGV + +LDDGLE  H D+  NYDP +S D NDND DP P   P   N+HGTRCA EIAM ANN+ CGVG+AYN K+GGIRMLDG V   IEA S+GFN  H+DIYS+SWGP DDGKT+E P +L Q+    G   GRNGKG+IFVWASGNGG   D+C CDGY  S+Y IS++S +     P++AEKC ST+   YS+   +   + +AD+  +CT+ H+GTSASAP AAGIFAL LE NPNLTWRD++HL+ WTSEY+ +  N GWKKN AG  VN++FGFGLLNA  +V  A  + W+ VP    C VK KS   +++       I      C+ +   +A +E + +   I Y  RG L + L SP G  T LL  R  DKS +G  NW F SVH WGENPTG WV+ + D ++      G + +  L  +GT T P+++K  +
Sbjct:   15 LLAACCLARGGGAERQFLNEWAAEVPAGPDAARAIAEELDYDLVGQIGSLKNHYLFRHKSHPR-RSRRSAVHITKRLSDDERVSWAEQQYEKKRTKR-AAVTD---------------SAENLFNDPMWNQQWYLQDTRITPSLPKLDLHVIPVWQKGITGKGVVITVLDDGLEWNHTDIYANYDPKASYDFNDNDHDPFPRYDPTNENKHGTRCAGEIAMQANNRKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGFNPEHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGIKQGRNGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATAYSSGDYTDQRITSADLHNECTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPLAGNPGWKKNGAGLMVNSRFGFGLLNANALVDLADPKRWRGVPEKRECIVKDKSFEPRLLRANEEVIIEIPTKACEGQENSIASLEHVQLEATIEYSRRGDLHVTLVSPSGTTTVLLAERERDKSPNGFKNWDFMSVHTWGENPTGTWVLRITD-VSKRIQNEGRIVNWKLILHGTGTQPEHMKQPR 605          

Query:  206 EWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKA--QNWKNVPPMTTCRVKVKS--SKMISNKLPATIIAYGNHCKEK---VAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKTTPDYIKNSK 1954
            EWA ++  G  AA++IA++ G++ +G IG+L N + FR +S    R +RS    T+ LS   ++S    Q   + +KR              KR   R     +FNDP W  +WYL D+R        D+ V PVW   ITGKGV + +LDDGLE  H D+  NYDP +S D NDND DP P   P   N+HGTRCA EIAM ANN+ CGVG+AYN K+GGIRMLDG V   IEA S+GFN  H+DIYS+SWGP DDGKT+E P +L Q+    G   GRNGKG+IFVWASGNGG   D+C CDGY  S+Y IS++S +     P++AEKC ST+   YS+   +   + +AD+  +CT+ H+GTSASAP AAGIFAL LE NPNLTWRD++HL+ WTSEY+ +  N GWKKN AG  VN++FGFGLLNA  +V  A  + WK VP    C VK KS   +++       I      C+ +   +A +E + +   I Y  RG L + L SP G +T LL  R  DKS +G  NW F SVH WGENP G WV+ + D ++      G + +  L  +GT T P+++K  +
Sbjct:   34 EWAAEVPAGPDAARDIAEELGYDLVGQIGSLKNHYLFRHKSHPR-RSRRSAIHITKRLSDDERVSWAEQQ---YEKKR-------------TKRATMRESAENLFNDPMWNQQWYLQDTRITPSLPKLDLHVIPVWQKGITGKGVVITVLDDGLEWNHTDIYTNYDPKASYDFNDNDHDPFPRYDPTNENKHGTRCAGEIAMQANNRKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGFNPEHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGIKQGRNGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATAYSSGDYTDQRITSADLHNECTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPLAGNPGWKKNGAGLMVNSRFGFGLLNANALVDLADPKRWKGVPEKRECIVKDKSFEPRLLRANEEVIIEIPTKACEGQENSIASLEHVQLEATIEYSRRGDLHVTLVSPSGTSTVLLAERERDKSPNGFKNWDFMSVHTWGENPRGTWVLRITD-VSRRIQNEGRIVNWKLILHGTATQPEHMKQPR 605          

Query:  155 LLILCVF----LVLTQAEYQWEWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQN--WKNVPPMTTCRVK--------VKSSKMISNKLPATIIAYGNHCKEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKTTPDYIKNSK 1954
            L +LC      +     +Y  EWAV+I  G  AA+ IA++ G+E +  IG L N + F+ +S  + R KRS +  T+ LS+  ++S    Q    R KR     D        K       V ++F+DP W  +WYL D+R        D+ V PVW   ITGKGV + +LDDGLE  H D+  NYDP +S D NDND DP P       N+HGTRCA EIAM A+N  CGVG+AYN K+GGIRMLDG V   IEA S+GFN +H+DIYS+          ME P +L Q+    G   GR GKG+IFVWASGNGG   D+C CDGY  S+Y IS++S +     P++AEKC ST+   YS+   +   +++              S S P+        +E NP+LTWRD++H++ WTSE++ + +N GWK+N AG  VN++FGFGLLNA  +V  A    WK+VP    C V+        +K++  IS ++P    A   +  E    +E + +  +I Y  RG L I L SP G  T LL  R  D S +G  NW F SVH WGENPTG W + + D     E+  G++    L  +GT   P+++K  +
Sbjct:   14 LAVLCALSSPGVNALDRQYLNEWAVEIPGGTDAAQSIANELGYELVRQIGALQNHYLFKHQSHPS-RTKRSADHITKRLSEDDRVSWAEQQYEKQRSKRAPLGAD-------CKEC----SVDKLFDDPMWNQQWYLQDTRTSPSLPKLDLHVIPVWKKGITGKGVVITVLDDGLEWNHTDIYPNYDPAASYDFNDNDPDPFPRYDSTNENKHGTRCAGEIAMQADNNKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGFNPDHVDIYSA----------MEGPGRLAQKAFEYGIQKGRGGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATAYSSGDYTDQRIVS-------------VSQSKPH--------IEFNPDLTWRDLQHIVVWTSEFDPLANNPGWKRNGAGLMVNSRFGFGLLNAKALVDLADPKVWKHVPEKKQCIVRDDSFQPRPLKAAGEISIEIPTKACAGQTNSIES---LEHVQVEASIEYTRRGDLHITLTSPSGTTTVLLAERERDTSSNGFRNWDFMSVHTWGENPTGTWTLKITDTSGRMENE-GQILSWKLILHGTSEKPEHMKKPR 580          

Query:  197 YQWEWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRN---LSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTCRVKVKSSKMISNKLPATII-----AYG--NHCKEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKIND--DEDRSGEVTDCTLEFYGTKTTPDYIKNSKTRRRNYDETMDE 1990
            Y   WAV+I  G   A+ IA  +G+  LG IG+L + +HF    +     KRS  S+      +S   K+  +  Q +  R KRD K +    + + ++    +   +  FND KW   WY+  +    + +S DM +   W    TGK V V ILDDG+E  HPDL+ NYD  +S D+N ND DP P       N+HGTRCA E+A SANN  C VGIAYN KIGG+RMLDG V  ++EAKSL  +  HIDIYS+SWGP DDGKT++ P+ L ++    G   GR G+G+IFVWASGNGG  +D CSCDGY +S+Y IS++S  +  + P++ E+C ST+  TYS+       +I  D++ +CT  H+GTSASAP AAGI AL LE N  LTWRD++H+I  TS    +     WK NAAG+ V+  +GFGL++A  MVK+A+ WK VPP   C     + K I    P  ++     A G  ++    V ++E +++ + IT+  RG L I L SP G  + LL  R  D S +G  NW F + H WGE   G W++ + D  +    +   G++ + +L  YGT   P   ++ K R    + + DE
Sbjct:   31 YTNHWAVRITGGAELAERIASRYGYRNLGQIGDLKDYYHFFHSRT----IKRSTLSSRGTHSFISMEPKVQWMEQQVVKRRVKRDYKSS----YTSAVQSSPAQSDSI-FFNDAKWSSMWYIHCNDNIHNCQS-DMNIVGAWKRGYTGKDVVVTILDDGIERNHPDLVQNYDNQASYDVNGNDLDPMPRYDVSNENKHGTRCAGEVAASANNSHCTVGIAYNAKIGGVRMLDGDVTDMVEAKSLSLHPQHIDIYSASWGPDDDGKTVDGPAALARQAFENGIRLGRKGRGSIFVWASGNGGRSRDHCSCDGYTNSIYTISISSTAESGRKPWYLEECASTLTTTYSSGENYDRKIITTDLRQRCTDSHTGTSASAPMAAGIIALALEANTLLTWRDVQHIIVKTSRAGHLSAP-DWKTNAAGYNVSHLYGFGLMDAEAMVKEAERWKPVPPQHIC--VENADKQIRTIRPEHVVRSVYKATGCTDNANNHVIYLEHVVVRITITHPRRGDLSINLTSPSGTKSQLLANRLFDHSMEGFKNWEFMTTHCWGEKAAGDWILEINDTPSQLRSQKTPGKLKEWSLVLYGTSVHPYSFRSEKPRSTVENPSDDE 627          

Query:  182 LTQAEYQWEWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTCRVK-VKSSKMISNKLPATIIAYGNHCKEKVAFIESI---IILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKTT---PDYIKNSKT 1957
            L Q  Y   WAV I  GE  A  +A    F   G I    + +HFR         +R V+   R+LS+H    + +H        R+ +++       ++KR + +R +     DPK+  +WYL++S         D+ V   W   +TGKGV V+ILDDG+E  HPDL  NYDP +S D+ND D DP P  T    N HGTRCA E+A  ANN ICGVG+AYN KIGG+RMLDG V   +EA+SL  N  HIDIYS+SWGP DDGKT++ P+KL ++   RG   GR G G+IFVWASGNGG  +DSC+CDGY +S+Y +S++S T     P+++E C ST+  TYS+   ++  +I  D++ KCT  H+GTSASAP AAGI AL LE N NLTWRD++HL+  TS    +  +  W+ N  G  V+  +G+GLL+A  +V  A+NW NV P   C +  V   K I + L   I    + C  K  F+ S+      + ++Y  RG L I L SP G  +TLL  R  D S +G  +W F + H+W E+P G+W + +E+K    +   G +T  TL  YGT ++   P    +S+T
Sbjct:   25 LGQKVYTNTWAVHITGGEEEANRLARKHDFINHGNI--FGDYYHFR--------HRRVVK---RSLSEHRGTHIRLH--------REPQVS--WAEQQVVKR-RKKRDIYSEPADPKFAQQWYLYNSNH------RDLNVKEAWKQGVTGKGVVVSILDDGIEMNHPDLERNYDPDASYDVNDGDPDPQPRYTQLNDNRHGTRCAGEVAAVANNDICGVGVAYNAKIGGVRMLDGEVTDAVEAQSLSLNPQHIDIYSASWGPEDDGKTVDGPAKLAKDAFLRGVTEGRGGLGSIFVWASGNGGREKDSCNCDGYTNSIYTLSISSSTQYGNVPWYSEACSSTLATTYSSGGLNEKQIITTDLRQKCTDSHTGTSASAPLAAGIIALALEANKNLTWRDMQHLVVRTSNPAHLTTD-DWRTNGVGRKVSHSYGYGLLDAAAIVALAKNWTNVGPQQKCVLSLVSEPKNIGSHL--VISKNVDSCAGKPNFVSSLEHAQAQLTLSYNRRGNLAIYLISPQGTRSTLLAGRPHDYSSEGFNDWAFMTTHSWDEDPRGEWTLEIENKAGLSD--FGTLTQFTLILYGTASSSGGPSTADSSQT 588          

Query:  182 LTQAEYQWEWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTCRVK-VKSSKMISNKLPATIIAYGNHCKEKVAFIESI---IILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKTT---PDYIKNSKT 1957
            L Q  Y   WAV I  GE  A  +A    F   G I    + +HFR         +R V+   R+LS+H    + +H        R+ +++       ++KR + +R +     DPK+  +WYL++S         D+ V   W   +TGKGV V+ILDDG+E  HPDL  NYDP +S D+ND D DP P  T    N HGTRCA E+A  ANN ICGVG+AYN KIGG+RMLDG V   +EA+SL  N  HIDIYS+SWGP DDGKT++ P+KL ++   RG   GR G G+IFVWASGNGG  +DSC+CDGY +S+Y +S++S T     P+++E C ST+  TYS+   ++  +I  D++ KCT  H+GTSASAP AAGI AL LE N NLTWRD++HL+  TS    +  +  W+ N  G  V+  +G+GLL+A  +V  A+NW NV P   C +  V   K I + L   I    + C  K  F+ S+      + ++Y  RG L I L SP G  +TLL  R  D S +G  +W F + H+W E+P G+W + +E+K    +   G +T  TL  YGT ++   P    +S+T
Sbjct:   25 LGQKVYTNTWAVHITGGEEEANRLARKHDFINHGNI--FGDYYHFR--------HRRVVK---RSLSEHRGTHIRLH--------REPQVS--WAEQQVVKR-RKKRDIYSEPADPKFAQQWYLYNSNH------RDLNVKEAWKQGVTGKGVVVSILDDGIEMNHPDLERNYDPDASYDVNDGDPDPQPRYTQLNDNRHGTRCAGEVAAVANNDICGVGVAYNAKIGGVRMLDGEVTDAVEAQSLSLNPQHIDIYSASWGPEDDGKTVDGPAKLAKDAFLRGVTEGRGGLGSIFVWASGNGGREKDSCNCDGYTNSIYTLSISSSTQYGNVPWYSEACSSTLATTYSSGGLNEKQIITTDLRQKCTDSHTGTSASAPLAAGIIALALEANKNLTWRDMQHLVVRTSNPAHLTTD-DWRTNGVGRKVSHSYGYGLLDAAAIVALAKNWTNVGPQQKCVLSLVSEPKNIGSHL--VISKNVDSCAGKPNFVSSLEHAQAQLTLSYNRRGNLAIYLISPQGTRSTLLAGRPHDYSSEGFNDWAFMTTHSWDEDPRGEWTLEIENKAGLSD--FGTLTQFTLILYGTASSSGGPSTADSSQT 588          

Query:  209 WAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMV--IHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLE-MFNDPKWPDEWYLFDSRFDSDQKSY-DMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTCRVK-VKSSKMISNKLPATIIAYGNHCK----EKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDED-RSGEVTDCTLEFYGTKTTPDYIKNSKTR 1960
            WAV+I  G+  A  IA+ +GF  +G IG L + ++F       G  KRS   +  N S  S  S V  I Q+++HR+               +KR +   +    +FNDPKW   WY+       D     DM +  VW    TG GV V+ILDDG+E  HPDL  NYD  +S D+N ND DP+P       N+HGTRCA  +A +ANN +C VGIAYN +IGG+RMLDG +  ++EA+SL     +IDIYSSSWGP DDGKT++ P  L +  L  G   GR G+G+IFVWASGNGG  +D CSCDGY +S++ IS+ S T   + P++ E+C ST+  TYS+       ++  D++ +CT +HSGTSASAP AAGI AL LE NP LTWRD++H+I  TS    +     W+ N AG+ V+  +GFGL++A  MVK+A+ W+ VP    C  + V+++++IS +    ++   + C     + VA++E +II + IT+  RG L I L SP G  + LL  R  D S DG + W F + H WGE   G W++ + D  +   + R G++ +  L FYGT + P Y ++ + R
Sbjct:   34 WAVRIRGGQENADLIAEKYGFLNMGQIGGLKDHYNFLHP----GGMKRSTVESRGNHSLISTESEVEWIQQQMVHRR---------------VKRTERASQTHSTLFNDPKWSSMWYIH-----CDHNCLTDMNIKAVWRRGYTGNGVVVSILDDGVERLHPDLKQNYDARASHDVNGNDSDPTPRYDATNENKHGTRCAGVVAAAANNSLCMVGIAYNARIGGVRMLDGDMTDMVEAQSLSLRQQYIDIYSSSWGPDDDGKTVDGPGPLARLALENGIRKGRKGRGSIFVWASGNGGQRKDHCSCDGYTNSIFTISLGSTTQSGRKPWYLEECSSTLATTYSSGESQGLGIVTTDLRQRCTDEHSGTSASAPIAAGIIALTLEANPLLTWRDVQHIIVKTSRRGHLS-APDWQSNGAGYDVSHLYGFGLMDAEAMVKEAETWREVPTQHVCEERTVQNARVISPEKVLRLLYKSSGCSAQRTQHVAYVEHVIIRVTITHPRRGDLSIALTSPAGTKSQLLALRPNDHSTDGFVKWEFMTTHCWGEKAAGDWILEIRDSPSLKRNTRPGKLMEWALVFYGTSSHP-YQRHEQPR 601          

Query:  242 AKEIADDFGFEYLGIIGNLDNMFHF-RKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNE---HGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISV 1150
            A+++A   G E  G IG L   + +    +  +G  +++   A R   +H  +   + Q+ L R KR                          FNDPK+P +W+L   + ++     D+ VT VW   +TGKGV VA++DDG+EHT PDL  NY      + + +  D   D  PGT ++   HGTRCA EIA  ANN +CGVG AY+ ++ GIR+LDGP+   +EA +   +     IYS SWGP DDGKT++ P  L Q  L+RG + GR G G IFV ASGNGG YQD+C+ DGY +S+Y I++
Sbjct:   10 ARDVAASLGLENHGQIGELTGTYLYSHPHTGLSGNARKTTHDALR---QHRSVLWSVEQKGLRRVKRSLP-----------------------FNDPKFPKQWHL---QRNTHTPGMDLNVTGVWERGVTGKGVVVAVVDDGVEHTLPDLQSNY----CAEGSYDLTDGDQDPRPGTGDQESRHGTRCAGEIAAVANNSLCGVGAAYDSRVAGIRLLDGPLTDHMEATAFNTHYQLNHIYSCSWGPDDDGKTVDGPHVLGQSALQRGVVGGRRGFGTIFVVASGNGGRYQDNCNYDGYANSIYTITI 283          

Query: 1040 GRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYS--ASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYN---WIKDNLGWKKNAAGFWVNAK--------------------FGFGLLNAYKMVKKAQNWKNVPPMTT---CR-VKVKSSKMISNKLPATIIAYGNHCK---EKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDK-SKDGIINWPFHSVHNWGENPTGKWVVYV------EDKINDDEDRSGEVTDCTLEFYGTKTTP 1933
            GR GKG+++VWASG+GG Y D C+CDGY SS++ IS+NS  +D +   + E C ST+ +T+S     + +  +   D+ G CT +HSGTSA+AP AAG+FAL +E N   T   I      TS+ N   ++  + G+      F +  +                    F         +      ++  PP+ +   CR V       +  +    +    + C+   + V ++E + +++ +    RG L + L SP G  + LL  R  D  S+ G   WPF + H WGE+P G+W + V      E        RSG +++ TL  +GT + P
Sbjct:    2 GRGGKGSVYVWASGDGGSYDD-CNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKKDPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALAIEANHPETAPCIARRTT-TSDANRAFFVTKSRGFLGICHDFHLQKQPTTHLTAFRGEDVCCDIAGHFSRSTEQQQHLATFRSPFRTFPPLRSRSPCRCVPCVPCSAVPGQGRLVLTVDTDACEGRADHVRYLEHVQVVVTVNATRRGDLTLNLTSPMGTRSLLLGRRPRDSDSRVGFHRWPFMTTHTWGEDPRGRWTLEVGFADGAEGPAAAAAARSGVLSEWTLMLHGTHSPP 336          

Query: 1040 GRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYS--ASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEM-------NPNLTWRDIKHLIAWTSEYN--WIKDNLGWKKNAAGFWVNAKFGF-GLLNAYKMVKKAQNWKNVPPMTTCRVKVKSSKMISNKLPATIIAYGNHCK---EKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDK-SKDGIINWPFHSVHNWGENPTGKWVVYV------EDKINDDEDRSGEVTDCTLEFYGTKTTPDYI---------KNSKTRRRNYDETMDE 1990
            GR GKG+++VWASG+GG Y D C+CDGY SS++ IS+NS  +D +   + E C ST+ +T+S     + +  +   D+ G CT +HSGTSA+AP AAG+FAL +E        N + +   + H  + +       I            F+V    GF G+ + + + K+         +T  R +   +     +L  T+    + C+   + V ++E + +++ +    RG L + L SP G  + LL  R  D  S+ G   WPF + H WGE+P G+W + V      E        RSG +++ TL  +GT  +P Y+         K + +RR+  ++ + E
Sbjct:    2 GRGGKGSVYVWASGDGGSYDD-CNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKKDPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALAIEAKGVEWLHNTSASVSLLPHSRSQSHPETAPCIARRTTTSDANRAFFVTKSRGFLGICHDFHLQKQPTTH-----LTAFRGEDVCAVPGQGRLVLTVDT--DACEGRADHVRYLEHVQVVVTVNATRRGDLTLNLTSPMGTRSLLLGRRPRDSDSRVGFHRWPFMTTHTWGEDPRGRWTLEVGFADGAEGPAAAAAARSGVLSEWTLMLHGTH-SPPYVGQVVHDSGSKLAMSRRQELEQELGE 340          

Query:  197 YQWEWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPF 709
            Y   WAV +  G  AA ++A   GF  LG I    + +HFR  +            A R+LS+H       H R L  QK + K+        ++K  + +R++ +   DPK+  +WYL +S        +D+ V   W   ++G+GV V+ILDDG+E  HPDL+ NYDP 
Sbjct:   32 YTHTWAVLVPGGAAAADDVAGRHGFTNLGQI--FGDYYHFRHRAV-----------AKRSLSRH-------HNRNLKLQK-EPKV--QWAEQQVVK-ARRKRELFQEPTDPKYLLQWYLHNS------VHHDLNVLAAWSQGVSGRGVVVSILDDGIEKNHPDLVSNYDPM 172          

Query:  518 FNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNA--------KFGFGLLNAYKMVKKAQNWKNVPPMT---TCRVKVKSSKMISNKLPATIIAYGNHCKEKVAF--IESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKIN 1864
             NDP +  +W+L +  F       D+ V  +WY NITG GV  AI+DDGL++ + DL DN   F +    D +D+ +      + + HGTRCA EIA    N  CGVG+ YN KI GIR+L G +    EA SL +  +  DIYS SWGP DDG+ ++ PS LV++ L +G   GR+ KG I+V+ASGNGG   D+C+ DGY +S+Y I++ +I   +  P ++E C + M  TYS+ S  +Y + ++D+ G+C+  H GTSA+AP AAG++ L+LE NPNLTWRD+++L         I   +G +KNA G W ++        ++GFG ++A+K+++ ++ W+NV   T      + V  S   + +   ++I       +   F  IE + + ++I  EIRG   + L SP G+ + L   R  D S +G  +W F SV +WGEN  G W + V+   N
Sbjct:  133 INDPLFERQWHLVNPSF----PGSDINVLDLWYNNITGAGVVAAIVDDGLDYENEDLKDN---FCAEGSWDFNDNTNLPKPRLSDDYHGTRCAGEIAAKKGNNFCGVGVGYNAKISGIRILSGDITTEDEAASLIYGLDVNDIYSCSWGPADDGRHLQGPSDLVKKALVKGVTEGRDSKGAIYVFASGNGGTRGDNCNYDGYTNSIYSITIGAIDHKDLHPPYSEGCSAVMAVTYSSGS-GEY-IHSSDINGRCSNSHGGTSAAAPLAAGVYTLLLEANPNLTWRDVQYLS--------ILSAVGLEKNADGDWRDSAMGKKYSHRYGFGKIDAHKLIEMSKTWENVNAQTWFYLPTLYVSQSTNSTEETLESVITISEKSLQDANFKRIEHVTVTVDIDTEIRGTTTVDLISPAGIISNLGVVRPRDVSSEGFKDWTFMSVAHWGENGVGDWKIKVKTTEN 577          

Query:  209 WAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQ--NWKNVPPMTTCRVKV-KSSKMISNKLPATIIAYGNHCK---EKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKTTPDY 1939
            WA+ +  G   AKE+A   GFE +  IG L+  +H    S  + R +RS E  T  L +H  ++ V  Q    R+KR     D M+   I+ R          F DP W  +WYL D R D+D    D+ V PVW   I+GKGV V ILDDG+EH H DLI NYDP +S D+ND D+DP P   P   N+HGTRCA E+A  ANN  CGVG+A+N +IGG+RMLDG V   +EA+SL  N  +IDIYS+SWGP DDG T+E P  L       G   GR G G+IFVWASGNGG + DSC+CDGY  S+Y +S++S +D  + P+++E C ST+  T+S+ +  +  ++  D+   CT++H+GTSASAP AAGIFAL LE+NP LTWRD++H++  TS +  +K +  W KN     VN KFGFGLL A K+V  A    +  VP    CR ++ + +K+     P TI      C    +++ ++E + +++++ Y  RG L+I L SP G  + LL+ R  D S +G   WPF + H+WGE+P G W + ++D + D++   G + +  L  +GTK  P +
Sbjct:   45 WAIHVNGGIEEAKEVAKAHGFEKVEPIGTLEGYYHLEHPSHPS-RSRRSAEDRTDQLRQHRHVTWVEQQHEKVREKR-GFYHDRMVARGIVPR----------FKDPLWDAQWYLDDKRKDTD---LDIHVIPVWKKGISGKGVVVTILDDGIEHNHTDLIKNYDPNASWDVNDGDNDPFPRYDPTNENKHGTRCAGEVAAEANNTKCGVGVAFNARIGGVRMLDGRVTDKVEAESLSLNPQYIDIYSASWGPSDDGATVEGPGTLATAAFLNGIQKGRGGLGSIFVWASGNGGRHGDSCNCDGYTDSIYTLSISSASDHGESPWYSESCSSTLATTFSSGAHGEKRIVTTDLHNTCTERHTGTSASAPLAAGIFALALEVNPKLTWRDMQHIVVHTSNHLPLKHDQDWSKNGIDLMVNRKFGFGLLVAEKIVDMANPATYVTVPEKRFCRGQINQDAKVFKWDKPLTIQLPATGCSGTGDEIRYLEHVQLMVSLDYVRRGDLVIYLTSPMGTKSCLLSPRKEDSSNEGFSKWPFMTTHSWGEDPRGTWTLEIKD-LGDNKANHGTLREWQLILHGTKDKPAH 611          

Query:  209 WAVKIEDGET-AAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRS--VESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYS---LIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTCRVKVKSSKM---ISNKLPATIIAYGNHCKEK-VAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKIN 1864
            WAV+++  E  AA  IA   GF  LG +G+L   +HF+       R +R   V   TR L +  ++     Q +L R ++      +++ H                 DPK+ D+WYLF+    +     D+ V P W  NITG+GV V+ILDDG++HTHPDL DN+D   ++   ++ D           N HGTRCA E+A +ANN +CGVG+AYN  IGG+RMLDG    ++E  SL F + +IDIYS+ WGP DDGKT  +P KL QE L +GAL GR G+GNI+VWA+GNGGL  D C+CDGY +S+Y IS+  I D     Y+ E C ST+  T++  S  +     ++  D+  KCT++  GTS++AP AAG+ ALVLE NPNL+WRD++HL+  T++     D  GW KN AG+  N KFGFG L+A  MVK+A+ WK+V P   C     S++        L  TI        +K +  +E + + ++  +  RG + I L SP G    +L+TR  D SK+G+ +W F +VHNWGENP G+WV+ V D ++
Sbjct:    6 WAVQLDSAEVEAADRIAAKHGFTNLGQVGSLKGYYHFKHVHKPGNRARRELHVHEKTRLLMQEDEVLWAQRQHVLARTRK------YIVPH-----------------DPKFHDQWYLFNDGQSTGPAGVDIDVVPAWNRNITGRGVVVSILDDGVDHTHPDLRDNFDQ-KASYDFNDMDPDPRPRDSDPDNCHGTRCAGEVA-AANNDVCGVGVAYNANIGGVRMLDGQATDVLEGSSLSFQSAYIDIYSNCWGPKDDGKTFGKPGKLAQEALMQGALKGRGGRGNIYVWATGNGGLTDDDCNCDGYTTSIYTISIGCIGDHGLSAYYTELCSSTLGVTFNGGSHREREENKMVTTDLHHKCTEEFKGTSSAAPLAAGMIALVLEANPNLSWRDVQHLVVETAQVTSPVDE-GWMKNGAGYHFNHKFGFGRLDADAMVKRAKTWKSVAPQRICHGPSSSTQQEIPTGGTLSITIDTIACSGTDKMLTKLEHVTLTVSFQHRRRGDVSIDLFSPSGTRNEMLSTRRYDDSKNGLHDWTFMTVHNWGENPKGEWVMNVTDNLS 541          

Query:  209 WAVKIEDGE-TAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSA----SSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTCRVK-VKSSKMISNKLPATII-AYGNHC---KEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKIN 1864
            WAV+++  + + A  IA   GF+ LG IG L   + F  +S+ + R +RS+ES T+ L  H ++     QRIL RQKRD             + L H R+    ++DP +  +WYL ++   +  +  D+ V PVW    TGKGV V+ILDDGL+HTHPDL  NYDP  ++   ++ DD          N HGT+C  E+   A+N ICG G+A N  +GGIRMLDG     +EA +L +   +IDIYS+ WGP DDGKT  +P KL Q+ L  GA  GR GKG+I+VWA+GNGGL  D C+CDGY SS+Y IS+ +I+      Y+ E+C STM  T++     S E +Y+L+  ++  +CT    GTS++AP AAGIFALVLE NPNLTWRD++HL+  ++E     D  GWK N AG   N KFGFG L+A ++V  A  WK+VP    C+V+  ++ K I  +    I+  + + C   K  V  +E +   +++ +  RGAL I+++SP G  + LL+TR  D S +G+ +W F +VH WGE+P G+W V + D  +
Sbjct:    5 WAVQLDSNDGSLADAIARAHGFKNLGGIGTLTGHYEFVHDSTGS-RMRRSMESRTKRLISHPRVIWAKQQRILDRQKRDFFDLLEARASQQQRSLGHERRK-RFYHDPMFAKQWYLQNTGQFNIPEGNDIGVLPVWERGFTGKGVVVSILDDGLDHTHPDLKRNYDP-KASWDFNDKDDDPFPNDVDPYNAHGTKCGGEVGAQADNDICGAGVAPNVSLGGIRMLDGVATDALEANALSYKPQYIDIYSNCWGPKDDGKTFGRPGKLGQKALEDGAKKGRGGKGSIYVWATGNGGLVDDDCNCDGYTSSIYTISIGAISSYGLSTYYDEQCSSTMAVTFTGDSHRSGEEEYTLVTTNLHHECTDTFRGTSSAAPLAAGIFALVLEANPNLTWRDLQHLVVHSAEKTSPLDQ-GWKVNGAGIHFNHKFGFGRLHATRLVANALKWKHVPAQHICQVEGFQARKEIIKRNGKLILKVHTDGCAGTKNAVKRLEHVQATVSLKHNRRGALSIEIRSPMGTTSQLLSTRKYDTSTNGLKDWSFMTVHFWGEDPAGEWEVIITDNTD 562          

Query:  173 FLVLTQAEYQWEWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSL--IAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQN--WKNVPPMTTCRVKVKSSKM---ISNKLPATIIAYGNHCKEK-VAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKTTP 1933
            F++ ++  Y   W +  + G+     +A   GF+     G L+  F+  +    + R +RS+   + N  +   +S    Q+IL RQKR                          F DP + D+WYL +       K  D+ V PVW  NITGK V V ILDDG+E+THPDL  NYD  +S D N  D DP P  +P   N+HGTRCA E+A +  N  CGVG+AYN +IGGIRMLDG V  I+E KSL     +IDIYSSSWGP DDG+T++ P  + +   R G   GR G G+IFVWA+GNGG Y D C+CDGY++S+Y IS+ +I D  K P++AE CPST+  TYS+   +   L  +  D+  KCTK+H+GTSA+AP AAGIFALVLE NP LTWRD++HL+  TS+     D+  W  N AG  VN K+GFG+L++  +V+ AQ+  W+       CR    SS      + +L  T+ A G   K   V  +E + + + + ++ RGA+ I L SP G  + LL  R+ D S +G  NWPF +V +W ENP GKW + V +  +     +G      ++F+GT   P
Sbjct:   20 FVLASKPLYTNTWVIYTDKGQEYVDNLAAKHGFKSHRDGGGLEG-FYILEHQRTSKRMRRSLVHHSTNFLRDPHVSYAKQQKILRRQKRG-------------------------FVDPLFNDQWYLNNYGQTPGPKGLDINVLPVWRKNITGKNVVVTILDDGIEYTHPDLQQNYDKEASYDYNHYDSDPFPRYSPDNINKHGTRCAGEVA-AIKNTHCGVGVAYNARIGGIRMLDGDVTDIVEGKSLSLKTGYIDIYSSSWGPDDDGRTVDGPGPMAKRAFRDGIKKGRRGLGSIFVWATGNGGRYNDYCNCDGYITSIYTISIGAINDKGKSPWYAENCPSTLGVTYSSGQTNGPDLQIVTTDLHHKCTKEHTGTSAAAPLAAGIFALVLEANPKLTWRDLQHLVVNTSKKTDAGDSE-WITNGAGHHVNNKYGFGVLDSAALVELAQSPKWRTAEEQHVCREPGSSSSQEIPKNGELTLTLDATGCSGKSNCVTRLEHVRVYVTLRHDRRGAISIVLISPSGTRSDLLKQRSKDFSNNGFKNWPFMTVFSWNENPVGKWKLVVRNHAST----AGTFDRWFIKFFGTCQRP 582          

Query:  209 WAVKIEDG--ETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASS---ESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTCR-----VKVKSSKMISNKLPATIIAYGNHCKEKVAFI---ESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDK-INDDEDR 1879
            WAV+IE    E   +EI+   GF  +G IGNL   +H R +       K      T  L     +     Q+ILHR ++D   T                       DP + + WYL ++         D+ V PVW   ITG+GV V +LDDG++H HPDL  NY+P +S D NDND DP+P       N HGTRCA EIA  AN+ ICG G+AYN KIGG+RMLDG     +EA SLGF N   D+YS+ WGP DDGKT  +P  L  + L+ GA  GR GKGNIFVWA+GNGGL  D C+CDGY +S+Y +S+  I D     Y+ E C ST+  T++  +   + +  +I  D+KGKCT++  GTS++AP AAG+ AL+LE NP+LTWRD++H+I  T++     D+ GW+ N AG   N KFGFG L+A  MV+K++ WKNVP   TC         +    +   L   I   G  C   +A I   E +++ ++  +  RG + + L SP G    +L+TR  D SK+G+  W F +VH WGENP G W + V D  +N+  DR
Sbjct:    9 WAVEIEHPFEEKYVREISKRHGFTIIGKIGNLKGHYHLRHDDVDE-LNKEHNRDKTDRLLLEDNVRWAEQQKILHRVRKDGIPT-----------------------DPMFTEMWYLMNTGQTGGPVGVDINVIPVWKRGITGRGVVVTVLDDGMDHNHPDLKPNYEPCASHDFNDNDQDPAPRDID-PDNCHGTRCAGEIAAVANDSICGAGVAYNAKIGGVRMLDGKATDALEACSLGFANQVTDVYSNCWGPKDDGKTFGKPGPLAAKALKSGAEKGRGGKGNIFVWATGNGGLTDDDCNCDGYTTSIYTVSIGCIGDHGLSAYYTELCSSTLAVTFNGGAHREKEENKMITTDLKGKCTEQFKGTSSAAPLAAGMVALMLEQNPSLTWRDVQHIIVHTAKMTSPVDD-GWRTNGAGLHFNHKFGFGRLDADAMVEKSRVWKNVPVQRTCTGASSVTGDEKDIPVGGSLDIQIPTGG--CMGTIAEINHLEHVVLTVSFIHRRRGDVSLLLTSPSGTKNEMLSTRRYDDSKEGLDKWSFMTVHCWGENPRGFWKLNVIDNPLNEIGDR 551          

Query:  158 LILCVFLVLTQA------------EYQWEWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQ--NWKNVPPMTTCRVK--------VKSSKMISNKLPATIIAYGNHCKEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKTTPDYIKNSK 1954
            +++CVF +L               +Y  EWAV+I  G +AA+ IA +  +E +  IG LD+ +  +     + R KRS +  TR LS+  ++     Q    R KR             + R      V ++F+DP W  +WYL D+R  S     D+ V PVW   ITGKGV + +LDDGLE  H D+  NYD  +S D NDND DP P       N+HGTRCA EIAM A+N  CGVG+AYN K+GGIRMLDG V   IEA S+GFN NH+DIYS+SWGP DDGKT+E P +L Q+    G   GR GKG+IFVWASGNGG   D+C CDGY  S+Y IS++S +     P++AEKC ST+   YS+   +   + +AD+  +CT+ H+GTSASAP AAGIFAL LE NPNLTWRD++H+I WTSE++ + +N GWK+N AG  VN++FGFGLLNA  +V  A    WK+VP    C V+        +K++  I+ ++P    A   +    V  +E + +  +I Y  RG L I L SP G  T LL  R  D S +G  NW F SVH WGE+P G W + + D     E++ G +    L  +GT   P+++K  +
Sbjct:    8 VVMCVFAILCSGAPRSLGSPYADRQYLNEWAVEIPGGLSAAEAIARELDYELVRQIGALDDHYLLKHRRHPH-RMKRSADHITRQLSEDDRVLWAEQQYEKRRNKR------------AVIRECRDCSVDKLFDDPMWNQQWYLQDTRTSSSLPKLDLHVIPVWQKGITGKGVVITVLDDGLEWNHTDIYSNYDAAASYDFNDNDPDPFPRYDSTNENKHGTRCAGEIAMQADNNKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGFNPNHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGIQKGRGGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATAYSSGDYTDQRITSADLHNECTQTHTGTSASAPLAAGIFALALEQNPNLTWRDLQHIIVWTSEFDPLANNPGWKRNGAGLMVNSRFGFGLLNAKALVDLADPATWKHVPEKKICIVRDDSFQPRELKAAGEITIEIPTKACAGQENA---VRSLEHLQVEASIEYTRRGDLHITLTSPAGTTTVLLAERERDTSANGFRNWDFMSVHTWGEDPAGTWTLKITDTSGRMENK-GRILSWKLILHGTSEKPEHMKKPR 611          

Query:  197 YQWEWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTC-RVKVKSSKMISNKL---PATIIAYGNHCKEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGT------KTTPDYIKNSKTRRRNYD 1975
            Y   WAV+I  G   A  IA + GF   G +    + +HFR  + K                   + S+ IH+ +  + + + KI        ++K+ + +R + E   DP +P +WYL      S+    D+     W    TG+GV V ILDDG+E  HPDLI NYDP +S D+ND D DP P  T    N HGTRCA E+A +ANN +CGVG+AY+ KIGG+RMLDG V  ++EA+SL  N  HI IYS+SWGP DDGK+++ P+KL +E   +G   GR+G G+IFVWASGNGG  QDSC+CDGY +S+Y +S++S T     P+++E C ST+  T+S+ +  +  ++  D++ KCT  H+GTSASAP AAGI AL LE N NLTWRD++HL+  TS+   +     WK N  G  V+  +G+GLL+A  MV  AQNW  V P   C    +   + I NKL    +    +G    + V+ +E +   + +++  RG L + L SP G  +TLL  R  D S +G  +W F + H+W E+P G+W + +E+   +  D  G +T  TL  +GT       ++PD+ + S    + +D
Sbjct:   26 YTNSWAVQISGGPEEADRIAREHGFINHGNV--FGDYYHFRHHAVK-------------------RRSLSIHKGMHIKLQEEPKIL--WAEQQVVKK-RKKRDIYEDPTDPDFPKQWYL------SNPTHQDLDTKAAWAQGYTGRGVVVTILDDGIEKDHPDLISNYDPEASYDVNDGDADPQPRYTQRNENRHGTRCAGEVAAAANNGVCGVGVAYHAKIGGVRMLDGEVTDVVEARSLSLNPQHIHIYSASWGPEDDGKSLDGPAKLAKEAFIQGITKGRSGLGSIFVWASGNGGREQDSCNCDGYTNSIYTLSISSTTQSGSVPWYSEPCSSTLATTFSSGNPGEKQIVTTDLRQKCTDSHTGTSASAPLAAGIIALALEANMNLTWRDMQHLVVRTSQPGHLS-AADWKTNGVGRTVSHSYGYGLLDAAAMVGLAQNWTTVGPQHQCVHTMLAEPRDIGNKLVFSKSLDACWGR--PDYVSSLEHVQARLTLSHNQRGKLAVHLISPLGTRSTLLFPRPNDYSSEGFNDWAFMTTHSWDEDPQGEWTLEIENVAPNGHDY-GVLTQFTLLLWGTGPGLVNPSSPDFPRPSNNSCKTFD 594          

Query:  155 LLILCVFLVLTQAEYQWEWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFN---DPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTCRVKVKSS-KMISNKLPATIIAYGNHC---KEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFY 1915
            +L+  +     Q  Y   WAV I  G+  A  +A+  GF   G +    + +HFR          R+V  A R+LS H    +        R  RD  ++       ++KR   R    ++FN   DPK+ D+WYL      S+    D+     W    TGKGV V+ILDDG+E  HPDL+ NYDP +S D+ND D DP P  T    N HGTRCA E+A +A+N ICGVG+AYN KIGG+RMLDG V  ++EA+SL  N  HI IYS+SWGP DDGKT++ P+KL +E   RG   GR G G+IFVWASGNGG  +DSC+CDGY +S+Y +S++S T +   P+++E C ST+  TYS+ + ++  ++  D+K KCT  H+GTSASAP AAGI AL LE N NLTWRD++HL+  TS    +  N  W+ N  G  V+  +G+GLL+A  +V  A+NW NV P   C + + S  + I N L   I    + C      V  +E +   + ++Y  RG L I L SP G  +TLL  R  D S +G  +W F + H+W ENPTG W + +E+ +   +   G +T   L  Y
Sbjct:   27 MLVSGIGPTFCQNIYTNTWAVHIPGGQEEADRVAEKHGFINYGHV--FSDYYHFRH---------RTV--AKRSLSDHRGTKV--------RLLRDPMVS--WAEQQVVKRRIKR----DLFNEPLDPKFKDQWYL------SNSNHRDLNAKAAWQQGYTGKGVVVSILDDGIEKNHPDLMQNYDPDASYDVNDGDPDPQPRYTQLNDNRHGTRCAGEVAAAASNGICGVGVAYNAKIGGVRMLDGEVTDMVEAQSLSLNPQHIHIYSASWGPEDDGKTVDGPAKLAKEAFLRGVTEGRGGLGSIFVWASGNGGREKDSCNCDGYTNSIYTLSISSSTQNGNVPWYSEACSSTLATTYSSGNINEKQIVTTDLKSKCTDSHTGTSASAPLAAGIIALALEANQNLTWRDMQHLVVQTSHPAHLLAN-DWRTNGVGRKVSHSYGYGLLDAGAIVSLAKNWTNVKPQRKCVITMLSEPRNIGNHL--YINKSVDACIGSDSYVTSLEHVQARLTLSYNRRGNLAIHLISPAGTRSTLLHPRPHDYSSEGFNDWAFMTTHSWDENPTGTWRLEIENVVGASD--YGTLTQFVLVLY 582          

Query:  155 LLILCVFLVLT--QAEYQWEWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKIT--DHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTC-RVKVKSSKMISN--KLPATIIAYG--NHCKEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRS--GEVTDCTLEFYGTKTT 1930
            LL+LC   V +  +  Y   WAV+I  G   A  +A  +G+  LG IG L +++HF           R V  AT     H     +IH         D+++      +    +KR+         FNDPKW   WY+ + + D  +   DM V   W    TG+ V V+ILDDG+E  HPDL  NYD  +S D+N ND DP+P       N HGTRCA E+A +ANN  C VGIAYN  IGGIRMLDG V  I+EAKSLG   ++I IYS+SWGP DDG+T++ P  L ++   RG   GR G G+IFVWA+GNGG   D CSCDGY SS+Y ISV+S T++   P++ E C S M  TYS+    +  ++  D+  +CT  H+GTS SAP  AG+ AL LE N  L+WRD++HL+  TS    +K    WK NAAG  V+  +GFGL++A  MV +A+ W+ VPP  TC +V  + S+ I    +L ++I   G     ++ V  +E +++ + + +  RG L ++L SP G  + LL  R LD S +G  NW F +VH W E P G W + V+D  +   +    G + + TL  YGT  +
Sbjct:   33 LLVLCSSAVASGRRDRYTNHWAVQILGGPDQADAVAAKYGYRNLGQIGGLQDLYHFH--------HSRVVRRATL---PHRGPHSLIHL--------DAQVAWAQQQLVKPRVKRIAQTDPAFLGFNDPKWSSMWYI-NCQDDGGRCRSDMNVLAAWQRGYTGRNVVVSILDDGIERNHPDLSQNYDHLASYDINGNDHDPTPRYDSRNENVHGTRCAGEVAAAANNSQCIVGIAYNAHIGGIRMLDGDVTDIVEAKSLGIRPDYIHIYSASWGPKDDGRTVDGPGPLTRQAFERGIQKGRRGLGSIFVWAAGNGGRQADHCSCDGYTSSIYTISVSSTTENGNRPWYLEVCSSIMVTTYSSGEFHERKIVTTDLWQRCTDAHTGTSISAPIVAGVIALALEANFLLSWRDVQHLLVKTSRPAHLKAE-DWKTNAAGLTVSHLYGFGLVDADAMVMEARRWRPVPPQHTCSQVSGRRSRHIHAGLRLNSSITTSGCSGDPQQHVQHLEHVVVKVLLLHPRRGDLEMELISPAGTRSQLLARRLLDSSSEGFRNWEFMTVHFWAETPNGTWTLEVKDTPSKLRNLEVLGNLKEWTLILYGTSQS 614          

Query:  398 SMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTC-RVKVKSSKMISNKL---PATIIAYGNHCKEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGT------KTTPDYIKNSKTRRRNYD 1975
            S+ IH+ +  + + + KI        ++K+ + +R + E   DP +P +WYL      S+    D+     W    TG+GV V ILDDG+E  HPDLI NYDP +S D+ND D DP P  T    N HGTRCA E+A +ANN +CGVG+AY+ KIGG+RMLDG V  ++EA+SL  N  HI IYS+SWGP DDGK+++ P+KL +E   +G   GR+G G+IFVWASGNGG  QDSC+CDGY +S+Y +S++S T     P+++E C ST+  T+S+ +  +  ++  D++ KCT  H+GTSASAP AAGI AL LE N NLTWRD++HL+  TS+   +     WK N  G  V+  +G+GLL+A  MV  AQNW  V P   C    +   + I NKL    +    +G    + V+ +E +   + +++  RG L + L SP G  +TLL  R  D S +G  +W F + H+W E+P G+W + +E+   +  D  G +T  TL  +GT       ++PD+ + S    + +D
Sbjct:   68 SLSIHKGMHIKLQEEPKIL--WAEQQVVKK-RKKRDIYEDPTDPDFPKQWYL------SNPTHQDLDTKAAWAQGYTGRGVVVTILDDGIEKDHPDLISNYDPEASYDVNDGDADPQPRYTQRNENRHGTRCAGEVAAAANNGVCGVGVAYHAKIGGVRMLDGEVTDVVEARSLSLNPQHIHIYSASWGPEDDGKSLDGPAKLAKEAFIQGITKGRSGLGSIFVWASGNGGREQDSCNCDGYTNSIYTLSISSTTQSGSVPWYSEPCSSTLATTFSSGNPGEKQIVTTDLRQKCTDSHTGTSASAPLAAGIIALALEANMNLTWRDMQHLVVRTSQPGHLS-AADWKTNGVGRTVSHSYGYGLLDAAAMVGLAQNWTTVGPQHQCVHTMLAEPRDIGNKLVFSKSLDACWGR--PDYVSSLEHVQARLTLSHNQRGKLAVHLISPLGTRSTLLFPRPNDYSSEGFNDWAFMTTHSWDEDPQGEWTLEIENVAPNGHDY-GVLTQFTLLLWGTGPGLVNPSSPDFPRPSNNSCKTFD 590          

Query:    5 ETNVYCLSS*VVFLADLEKLYKYVIYSLKYTIIKKHWFLNKMNDVQVFRNLLILCVFLVLTQAEYQWEWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTCRVKVKSSKMISNKLPATIIAYGNHCKEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKTTPDYIKNSKTRRRNYDETMDEDEI 1999
            ET  YC  S      DLEKLYKYVIYSLKYT+IKKHWFLNKMNDVQVFRNLLILCVFLVLTQAEYQWEWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFSSTDLNDNDDDPSPDLTPGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTCRVKVKSSKMISNKLPATIIAYGNHCKEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKTTPDYIKNSKTRRRNYDETMDEDEI
Sbjct:   27 ETEGYCSHS------DLEKLYKYVIYSLKYTLIKKHWFLNKMNDVQVFRNLLILCVFLVLTQAEYQWEWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFSSTDLNDNDDDPSPDLTPGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTCRVKVKSSKMISNKLPATIIAYGNHCKEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKTTPDYIKNSKTRRRNYDETMDEDEI 685          

Query:    5 ETNVYCLSS*VVFLADLEKLYKYVIYSLKYTIIKKHWFLNKMNDVQVFRNLLILCVFLVLTQAEYQWEWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTCRVKVKSSKMISNKLPATIIAYGNHCKEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKTTPDYIKNSKTRRRNYDETMDEDEI 1999
            ET  YC  S      DLEKLYKYVIYSLKYT+IKKHWFLNKMNDVQVFRNLLILCVFLVLTQAEYQWEWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFSSTDLNDNDDDPSPDLTPGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTCRVKVKSSKMISNKLPATIIAYGNHCKEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKTTPDYIKNSKTRRRNYDETMDEDEI
Sbjct:   27 ETEGYCSHS------DLEKLYKYVIYSLKYTLIKKHWFLNKMNDVQVFRNLLILCVFLVLTQAEYQWEWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFSSTDLNDNDDDPSPDLTPGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTCRVKVKSSKMISNKLPATIIAYGNHCKEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKTTPDYIKNSKTRRRNYDETMDEDEI 685          

Query:    5 ETNVYCLSS*VVFLADLEKLYKYVIYSLKYTIIKKHWFLNKMNDVQVFRNLLILCVFLVLTQAEYQWEWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTCRVKVKSSKMISNKLPATIIAYGNHCKEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKTTPDYIKNSKTRRRNYDETMDEDEI 1999
            ET  YC  S      DLEKLYKYVIYSLKYT+IKKHWFLNKMNDVQVFRNLLILCVFLVLTQAEYQWEWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFSSTDLNDNDDDPSPDLTPGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTCRVKVKSSKMISNKLPATIIAYGNHCKEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKTTPDYIKNSKTRRRNYDETMDEDE+
Sbjct:   27 ETEGYCSHS------DLEKLYKYVIYSLKYTLIKKHWFLNKMNDVQVFRNLLILCVFLVLTQAEYQWEWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFSSTDLNDNDDDPSPDLTPGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTCRVKVKSSKMISNKLPATIIAYGNHCKEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKTTPDYIKNSKTRRRNYDETMDEDEM 685          

Query:  185 TQAEYQWEWAVKIEDGETAAKEIADDFGFEYLGIIGNLDNMFHFRKESSKNGRFKRSVESATRNLSKHSKISMVIHQRILHRQKRDSKITDHMIHHNIIKRLQHRRKVLEMFNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTS-----NEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNL---GWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTCRVKVK------SSKMISNK-LPATIIAYGNHCKEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLDKSKDGIINWPFHSVHNWGENPTGKW--VVYVEDKINDDEDRSGEVT--DCTLEFYGTKTTPDYIKNS---KTRRR 1966
            ++  Y   WAV+I      A+ +A  +GF +L  I      F  R+ S      KRS+  +    S  S    VI    L +Q    ++  H++                  NDPKW   WYL     +   K   M +   W     G+ V V+ILDDG+E  HPDL +NYDP +S D+  ND++P P      +     N HGTRCA ++A +ANN+ICGVG+AY   IGGIRMLDG V+  +E+ SL     HIDIYS+SWGP DDGKT++ P +L +     G L GRNG G+IFVWASGNGG   D+C+CDGY +S++ + VN++++    P++AEKC ST+  TYS+ S  + ++I  DV  +CT++HSGTSASAP+AAGI AL L  N  LTWRD++HL+  T+     K NL    W  NAAG   +  FGFGL++A  MV  A NW  VP    C           S K  +N+ L  T  A  ++ K++V ++E +   +++    RG + + L SP    + LLT R  D +  G  +WPF SVH WGE   G W   +Y  D          EVT  + +L  YGT T P + +NS   K+++R
Sbjct:   22 SRGHYTDTWAVQINGTVDDARILAATYGFVFLNEIMPSIYSFKHRRVS------KRSIYPSNYYQSNLSDDPRVI---WLEQQFAKVRVKRHIV------------------NDPKWYKMWYL-----NKMNKENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITAR----KANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYD---------AEVTLINWSLILYGTDTLPSHRQNSTHTKSQKR 592          

Query:  518 FNDPKWPDEWYLFDSRFDSDQKSYDMRVTPVWYMNITGKGVKVAILDDGLEHTHPDLIDNYDPFXXXXXXXXXXXXXXXXXXGTSNEHGTRCASEIAMSANNKICGVGIAYNCKIGGIRMLDGPVNGIIEAKSLGFNNNHIDIYSSSWGPLDDGKTMEQPSKLVQEVLRRGALSGRNGKGNIFVWASGNGGLYQDSCSCDGYVSSLYVISVNSITDDNKFPYFAEKCPSTMCATYSASSESKYSLIAADVKGKCTKKHSGTSASAPYAAGIFALVLEMNPNLTWRDIKHLIAWTSEYNWIKDNLGWKKNAAGFWVNAKFGFGLLNAYKMVKKAQNWKNVPPMTTCRVKVKSSKM-ISNKLPATIIAYGNHC--KEKVAFIESIIILMNITYEIRGALLIKLQSPYGMNTTLLTTRNLD--KSKDGIINWPFHSVHNWGENPTGKWVVYVEDKINDDEDRSGEVTDCTLEFYGTKTTPDYIKNSKTRRRN 1969
            F+DP +  +WYL  S+F++  K  DM V   W +  TGKGV ++ILDDG+++ H DL +NYDP  ++   + DD+        T N HGTRCA E++  ANN  CGVGIAYN +IG +RMLDG V   +EA++L F   HIDIYS SWGP D+G+ +E P+ L +   ++G   GRNG GNI+VWASGNGG   DSC+CDGY SS+Y IS++S++++N+ P++ E C ST+ +TYS+    +  +I+ D+  KC   H+GTSASAP AAGI AL++E N NLTWRD++++I  TS  +   D   +  N A   V+  +GFGL+++ K+V+  + W  +P    C++     K+ + +K    +    + C  K KV ++E +I+ + + Y+ RG L I L SP G  + +L  R  D  +       WP  SV  WGE  +G+W V + +        +G  ++  L+ YGT+  P  + ++++   N
Sbjct:    8 FSDPLFKKQWYLIRSQFNT--KLVDMNVKEAWELGYTGKGVTISILDDGIDYRHDDLKENYDP-EASFDINGDDNDPLPNLKSTENRHGTRCAGEVSAKANNSKCGVGIAYNSRIGAVRMLDGDVTDRVEAEALSFKQQHIDIYSGSWGPDDNGQKVEGPAILAKSAFKKGIRYGRNGLGNIYVWASGNGGKKSDSCACDGYASSIYTISISSVSENNRKPWYLESCASTLASTYSSGDGYEQKIISTDLNNKCAFDHTGTSASAPLAAGIIALLIEANSNLTWRDVQYIIVLTSNPHPFIDG-NFIVNGANKKVSNLYGFGLMDSGKLVRIGRLWHKLPSHHFCKISYNGKKISLKDKFTVKLSVKTDGCPGKNKVNYVEHVILYLKLDYDKRGDLRIILISPSGTRSEILPYRPHDFARGPSTFDIWPLMSVQFWGEKASGEWSVEINNYGTKFSKSNGVWSNFELKIYGTEKWPIRLISAESSENN 492