DNA replication licensing factor MCM7

Query:   28 MRNYESDKDKFKNFIENFYEETSDSKK-FIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEII-HGMGRATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIG-TAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKLKDPEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKSDRARQRTRLGYKELIYQAIRGLAADSSTVRMADISKKCVSMGFTPDQINEVIDSYEELNIWQVNVGRTRIVLV 2229
            +++Y  +K+K K F++ FY++    KK F Y  Q++ ++ +EQ A+Y+ LDD+ E D EL + I +N  RY KL   A+ E++     R  VNK   D++I+H L +EQ  RD       P  +   + ++P+EL+RR+E YF    ++K   IR V +  +G ++ ++ +V R + VKP M +ATYTCD+CG+ET+Q I + T +PL+ C ++ C+   + GRL+LQT+GS+++K QE+++QE SDQVP+GNIPRS+ V   G NTR+ QPGDHV +TG+FLP+L TG R + +GL++E +L+AH I ++ K E D+ G     T  EL ++ + + Y  +A SIAPEI+GHEDVKK LL+++ GG      G KIRG++NICLMGDPGVAKSQLL ++DRL PRSQYT GRGSSG GLTA+V+RD ++GE+TLE G+LVLAD G+CCIDEFDKM ++DRTAIHEVMEQQTISIAKAGI+TTLNAR SILAAANPAYGRYNPRR++EQNI LPAALLSRFDLLWLIQD+PDRD DLRLAQHI+YVH ++  PPS             PL M  +RRY+A+ R +  P VPE+L +Y+   Y+ MR+E+ A SK++ +TSAR+LLA++R+STAL+R++    V++ DV+EAIRL+E SK S+  D+ +        ++I+  +R L +   +VR ++  ++CVS GFTP Q    +D YEELN+WQVN  RTRI  V
Sbjct:    3 LKDYALEKEKVKKFLQEFYQDDELGKKQFKYGNQLVRLAHREQVALYVDLDDVAEDDPELVDSICENARRYAKLFADAVQELLPQYKEREVVNKDVLDVYIEHRLMMEQRSRD-------PGMVRSPQNQYPAELMRRFELYFQGPSSNKPRVIREVRADSVGKLVTVRGIVTRVSEVKPKMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQEHSDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIFLPILRTGFRQVVQGLLSETYLEAHRIVKMNKSEDDESGAG-ELTREELRQIAEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPSQFE----------PLDMKLMRRYIAMCREK-QPMVPESLADYITAAYVEMRREAWA-SKDATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMSKDSLLGDKGQTARTQRPADVIFATVRELVSGGRSVRFSEAEQRCVSRGFTPAQFQAALDEYEELNVWQVNASRTRITFV 719          

Query:  565 MKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIG-TAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKLKDPEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKSDRARQRTRLGYKELIYQAIRGLAADSSTVRMADISKKCVSMGFTPDQINEVIDSYEELNIWQVNVGRTRIVLV 2229
            M +ATYTCD+CG+ET+Q I + T +PL+ C ++ C+   + GRL+LQT+GS+++K QE+++QE SDQVP+GNIPRS+ V   G NTR+ QPGDHV +TG+FLP+L TG R + +GL++E +L+AH I ++ K E D+ G     T  EL ++ + + Y  +A SIAPEI+GHEDVKK LL+++ GG      G KIRG++NICLMGDPGVAKSQLL ++DRL PRSQYT GRGSSG GLTA+V+RD ++GE+TLE G+LVLAD G+CCIDEFDKM ++DRTAIHEVMEQQTISIAKAGI+TTLNAR SILAAANPAYGRYNPRR++EQNI LPAALLSRFDLLWLIQD+PDRD DLRLAQHI+YVH ++  PPS             PL M  +RRY+A+ R +  P VPE+L +Y+   Y+ MR+E+ A SK++ +TSAR+LLA++R+STAL+R++    V++ DV+EAIRL+E SK S+  D+ +        ++I+  +R L +   +VR ++  ++CVS GFTP Q    +D YEELN+WQVN  RTRI  V
Sbjct:    1 MVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQEHSDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIFLPILRTGFRQVVQGLLSETYLEAHRIVKMNKSEDDESGAG-ELTREELRQIAEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPSQFE----------PLDMKLMRRYIAMCREK-QPMVPESLADYITAAYVEMRREAWA-SKDATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMSKDSLLGDKGQTARTQRPADVIFATVRELVSGGRSVRFSEAEQRCVSRGFTPAQFQAALDEYEELNVWQVNASRTRITFV 543          

Query:  565 MKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIG-TAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKLKDPEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKSDRARQRTRLGYKELIYQAIRGLAADSSTVRMADISKKCVSMGFTPDQINEVIDSYEELNIWQVNVGRTRIVLV 2229
            M +ATYTCD+CG+ET+Q I + T +PL+ C ++ C+   + GRL+LQT+GS+++K QE+++QE SDQVP+GNIPRS+ V   G NTR+ QPGDHV +TG+FLP+L TG R + +GL++E +L+AH I ++ K E D+ G     T  EL ++ + + Y  +A SIAPEI+GHEDVKK LL+++ GG      G KIRG++NICLMGDPGVAKSQLL ++DRL PRSQYT GRGSSG GLTA+V+RD ++GE+TLE G+LVLAD G+CCIDEFDKM ++DRTAIHEVMEQQTISIAKAGI+TTLNAR SILAAANPAYGRYNPRR++EQNI LPAALLSRFDLLWLIQD+PDRD DLRLAQHI+YVH ++  PPS             PL M  +RRY+A+ R +  P VPE+L +Y+   Y+ MR+E+ A SK++ +TSAR+LLA++R+STAL+R++    V++ DV+EAIRL+E SK S+  D+ +        ++I+  +R L +   +VR ++  ++CVS GFTP Q    +D YEELN+WQVN  RTRI  V
Sbjct:    1 MVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQEHSDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIFLPILRTGFRQVVQGLLSETYLEAHRIVKMNKSEDDESGAG-ELTREELRQIAEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPSQFE----------PLDMKLMRRYIAMCREK-QPMVPESLADYITAAYVEMRREAWA-SKDATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMSKDSLLGDKGQTARTQRPADVIFATVRELVSGGRSVRFSEAEQRCVSRGFTPAQFQAALDEYEELNVWQVNASRTRITFV 543          

Query:   34 NYESDKDKFKNFIENFYEETS--------DSKKFIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIGTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPL-LNTGMRTLNRGLVTELFLDA-HFINRITKDES--DDLGETIPATEAELEKLKD----PEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXXXXT---KIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTS-ARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLL-EASKASVKSDR 2016
            N  + K+ F+ F++ F +  +        D  + +Y +++  I+   +  + ++ + I  FD  L          Y++LI Y   E+I     A VN+  FD + D  L+ +  +R                              F A KT    ++RN+  +++  +I +  +VIR + + P M+ A + C  C   T  E+    +     C     +  T   + L    S +   Q I++QE  + +P G  P ++ +         VQPGD V +TG++  + +    R  N   V +  +D  H+     K     D+  E    +E  +E LK+    P++Y  +A ++AP I+ HED+KKG+L+ + GG   D + T   K R  +NI L GDPG +KSQLL +V  L PR QYT+G+GSS  GLTA V++D  T ++ L+ G+LVL+D GICCIDEFDKM +S R+ +HEVMEQQT+SIAKAGI+  LNAR S+LAAANP   ++NP++T  +NI LP  LLSRFDL++L+ D  D   D RLA H+  ++  +E           + A    L MA L+ Y+A   S   P + E     L+  Y+ MR   K GS   + ++  R L +LIR++ A ++++   +V+ IDV+EA RL  EA K S    R
Sbjct:  108 NVAACKENFQRFLQRFIDPLAKEEENVGIDITEPLYMQRLGEINVIGEPFLNVNCEHIKSFDKNL----------YRQLISYP-QEVIPTFDMA-VNEIFFDRYPDSILEHQIQVRP-----------------------------FNALKTK---NMRNLNPEDIDQLITISGMVIRTSQLIPEMQEAFFQCQVCAHTTRVEMDRGRIAEPSVCG----RCHTTHSMALIHNRSLFSDKQMIKLQESPEDMPAGQTPHTVILFAHNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVSNVKSVYKTHIDVIHYRKTDAKRLHGLDEEAEQKLFSEKRVELLKELSRKPDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLLLDPQDEAYDRRLAHHLVALYYQSE-----------EQAEEELLDMAVLKDYIAYAHSTIMPRLSEEASQALIEAYVDMR---KIGSSRGMVSAYPRQLESLIRLAEAHAKVRLSNKVEAIDVEEAKRLHREALKQSATDPR 727          

Query:   34 NYESDKDKFKNFIENFYEETS--------DSKKFIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIGTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPL-LNTGMRTLNRGLVTELFLDA-HFINRITKDES--DDLGETIPATEAELEKLKD----PEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXXXXT---KIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTS-ARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLL-EASKASVKSDR 2016
            N  + K+ F+ F++ F +  +        D  + +Y +++  I+   +  + ++ + I  FD  L          Y++LI Y   E+I     A VN+  FD + D  L+ +  +R                              F A KT    ++RN+  +++  +I +  +VIR + + P M+ A + C  C   T  E+    +     C     +  T   + L    S +   Q I++QE  + +P G  P ++ +         VQPGD V +TG++  + +    R  N   V +  +D  H+     K     D+  E    +E  +E LK+    P++Y  +A ++AP I+ HED+KKG+L+ + GG   D + T   K R  +NI L GDPG +KSQLL +V  L PR QYT+G+GSS  GLTA V++D  T ++ L+ G+LVL+D GICCIDEFDKM +S R+ +HEVMEQQT+SIAKAGI+  LNAR S+LAAANP   ++NP++T  +NI LP  LLSRFDL++L+ D  D   D RLA H+  ++  +E           + A    L MA L+ Y+A   S   P + E     L+  Y+ MR   K GS   + ++  R L +LIR++ A ++++   +V+ IDV+EA RL  EA K S    R
Sbjct:  158 NVAACKENFQRFLQRFIDPLAKEEENVGIDITEPLYMQRLGEINVIGEPFLNVNCEHIKSFDKNL----------YRQLISYP-QEVIPTFDMA-VNEIFFDRYPDSILEHQIQVRP-----------------------------FNALKTK---NMRNLNPEDIDQLITISGMVIRTSQLIPEMQEAFFQCQVCAHTTRVEMDRGRIAEPSVC----GRCHTTHSMALIHNRSLFSDKQMIKLQESPEDMPAGQTPHTVILFAHNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVSNVKSVYKTHIDVIHYRKTDAKRLHGLDEEAEQKLFSEKRVELLKELSRKPDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLLLDPQDEAYDRRLAHHLVALYYQSE-----------EQAEEELLDMAVLKDYIAYAHSTIMPRLSEEASQALIEAYVDMR---KIGSSRGMVSAYPRQLESLIRLAEAHAKVRLSNKVEAIDVEEAKRLHREALKQSATDPR 777          

Query:   25 FMRNYESDKDKFKNFIENFYEETSDS--KKFIYREQVLNISKQEQQAIYISLDDINEFDS----ELAEVIEKNGFRYQKLICYAIDEIIH---GMGRATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIGTA-GRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKLK-DPEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKSDRARQRTRLGYKELIYQAIRGL-AADSSTVRMADISKKCVSMGFTPDQINEVIDSY 2175
            +  ++ ++K K ++F + +Y +  D   K F YR+QV  I+++++QAI +++D I E D     EL+E I  N  RY+ L    I ++I    G  +A V   A D ++   L +++N   +AN   + ++++D R K+P +LL+R+E YF     +    +RN+ + E+G ++ +K VVIRAT VKP +++ TYTCD C +E +Q +      P + C N+ C    A GRLH+Q +GSK+VK QE++IQE+S+QVP+G+IPR+M VH  G  TR    G+ V ++GVFLP++ +G R    GLV + +L+AH+IN +     DD         AELE L+   + Y  +A SIAPEIFGH DVKK LL+ + GG    + G KIRG +N+ +MGDPGVAKSQLLG+V+RL PRSQYT GRGSSG GLTA+V++D +TGEM+LE G+LVLADGGICCIDEFDKM D DRTAIHEVMEQQTISIAKAGIMTTLNAR +I+AAANPAYGRYNP R+IEQN+DLPAALLSRFDL+ L+QDK DR+ D  LA+HI+YVH +   P         +   L  +S+  LR Y+++ ++   P V   L   +V  Y+ MR++++  S +  F S R +L ++R++TA ++++  T VD  DV+EA+RL++ +K S++ ++ +   R+   +  +  +R L  AD++ + +++  ++C   G +   + + +D Y
Sbjct:    6 YNTDWAAEKTKIRSFFDEYYVDNEDGSGKAFPYRDQVFEIARRDKQAIVVNVDHIKESDIPDALELSEAITSNTKRYEVLFKDTISDMIQDYLGDKQAPV-IDALDAYMFQRLHMDRN-EGAAN---EEVSLQDKRKKYPPQLLQRFEVYFTTDDAAHETCVRNIKATEIGHLVSMKGVVIRATEVKPCVEVMTYTCDTCAAEVYQPVKGMQFTPPVNCPNKECVEAKANGRLHMQLRGSKFVKFQELKIQELSEQVPVGSIPRTMTVHVYGEMTRKCNTGNVVHVSGVFLPIMQSGFRPTG-GLVADTYLEAHYINNL-----DDNPTFNGVQSAELEVLRRKGDNYETLAASIAPEIFGHVDVKKCLLMALVGGNDNSSNGMKIRGCINVLMMGDPGVAKSQLLGYVNRLAPRSQYTTGRGSSGVGLTAAVMKDPVTGEMSLEGGALVLADGGICCIDEFDKMMDHDRTAIHEVMEQQTISIAKAGIMTTLNARTAIIAAANPAYGRYNPNRSIEQNVDLPAALLSRFDLILLMQDKADRENDKILAEHITYVHQHGCHPNR-------EKKDL--ISLETLREYISLCKTYT-PTVDPALRERIVEAYVEMRRDARYSS-DPTFVSPRMILGIVRMATARAKLRLSTIVDESDVEEALRLMQFAKDSLRPEQNKIEKRMAPVDAAFAVLRELYHADNAPIAISNAIQRCARKGISEVALKKCLDQY 712          

Query:  115 YREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIGTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRT--LNRGL--VTELFLDA-HFINRITKDESDDLGETIPATEAELEKL----KDPEMYSLMARSIAPEIFGHEDVKKGLL---XXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTS-ARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLL-EASKAS 2001
            Y E++L  +  E   I ++L  +N F   L          Y+K+I Y  D I +            DI ++       N                 RT   S  LR + A        K  ++R +   ++  +I +  +V R + + P M+   + C  C      E+    +   + CTN            L    S ++  Q +++QE  D +P G  P +++V+  G+    VQPGD + +TG+F     TGM+     R L  V    +DA HF    T     D GETI  TE  ++++    K P++   +A+SIAP I+ H+DVK+GLL                TK+R  +NI L GDPG +KSQ+L +V RL PRSQYT+G+GSS  GLTASV RD  T ++ L+ G+LVLAD G+CCIDEFDKM +S R+ +HEVMEQQT+SIAKAGI+  LNARAS+LAAANP   ++N  +TI +NI LP  LLSRFDL++LI D  D   D RL  H+  ++  N+          G+      + M  LR Y+A  ++   P + E    +++  Y+ MR   KAG++    T+  R L +LIR+S A ++I+   EV   DV++A  L  EA K S
Sbjct:  157 YMERLLECNDAEVTHINLNLKHLNAFSEAL----------YRKVIAYPADVIPY-----------LDIVVNEVFAERFN-----------------RTLAQSIELRPFNA-------QKTRNMRGLNPNDVDQLITISGMVTRTSSLIPEMRSGYFQCAVCAFGIESEVDKGRIEEPVVCTN----CSNTHCFQLVHNRSVFLDKQVVKLQESPDDMPSGETPHTVSVYAHGSLVESVQPGDRITVTGIFRA---TGMKVNPKQRALASVYRTSIDALHFRKMDTSRLHQDNGETI--TEERIQQIIELSKRPDIMDALAQSIAPSIYEHDDVKRGLLCLLFGGTRKDDETTNKTKLRSEINILLCGDPGTSKSQMLQYVYRLLPRSQYTSGKGSSAVGLTASVSRDADTKQLVLQTGALVLADNGVCCIDEFDKMNESARSVLHEVMEQQTLSIAKAGIICQLNARASVLAAANPVDSKWNRNKTIVENITLPHTLLSRFDLIFLIVDAQDEMQDRRLGNHLVSLYFEND----------GNQEKTEHVDMNLLRDYIAYAKANIHPKLSEEASQFIIEKYLFMR---KAGAQHGQITAYPRQLESLIRLSEAHAKIRLSQEVSVDDVEKAFTLWREALKQS 732          

Query:  115 YREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIGTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRT--LNRGL--VTELFLDA-HFINRITKDESDDLGETIPATEAELEKL----KDPEMYSLMARSIAPEIFGHEDVKKGLL---XXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTS-ARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLL-EASKAS 2001
            Y E++L  +  E   I ++L  +N F   L          Y+K+I Y  D I +            DI ++       N                 RT   S  LR + A        K  ++R +   ++  +I +  +V R + + P M+   + C  C      E+    +   + CTN            L    S ++  Q +++QE  D +P G  P +++V+  G+    VQPGD + +TG+F     TGM+     R L  V    +DA HF    T     D GETI  TE  ++++    K P++   +A+SIAP I+ H+DVK+GLL                TK+R  +NI L GDPG +KSQ+L +V RL PRSQYT+G+GSS  GLTASV RD  T ++ L+ G+LVLAD G+CCIDEFDKM +S R+ +HEVMEQQT+SIAKAGI+  LNARAS+LAAANP   ++N  +TI +NI LP  LLSRFDL++LI D  D   D RL  H+  ++  N+          G+      + M  LR Y+A  ++   P + E    +++  Y+ MR   KAG++    T+  R L +LIR+S A ++I+   EV   DV++A  L  EA K S
Sbjct:  157 YMERLLECNDAEVTHINLNLKHLNAFSEAL----------YRKVIAYPADVIPY-----------LDIVVNEVFAERFN-----------------RTLAQSIELRPFNA-------QKTRNMRGLNPNDVDQLITISGMVTRTSSLIPEMRSGYFQCAVCAFGIESEVDKGRIEEPVVCTN----CSNTHCFQLVHNRSVFLDKQVVKLQESPDDMPSGETPHTVSVYAHGSLVESVQPGDRITVTGIFRA---TGMKVNPKQRALASVYRTSIDALHFRKMDTSRLHQDNGETI--TEERIQQIIELSKRPDIMDALAQSIAPSIYEHDDVKRGLLCLLFGGTRKDDETTNKTKLRSEINILLCGDPGTSKSQMLQYVYRLLPRSQYTSGKGSSAVGLTASVSRDADTKQLVLQTGALVLADNGVCCIDEFDKMNESARSVLHEVMEQQTLSIAKAGIICQLNARASVLAAANPVDSKWNRNKTIVENITLPHTLLSRFDLIFLIVDAQDEMQDRRLGNHLVSLYFEND----------GNQEKTEHVDMNLLRDYIAYAKANIHPKLSEEASQFIIEKYLFMR---KAGAQHGQITAYPRQLESLIRLSEAHAKIRLSQEVSVDDVEKAFTLWREALKQS 732          

Query:   76 NFYEETSDSKKFIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLL-PLLTCTNEVCKIGTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRL---VQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAE-------LEKLKDPEMYSLMARSIAPEIFGHEDVKKGLL-XXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVH---TNNEAPPSVLTTAAG-----------------------DSAGLLP---LSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKE--SKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLL 1983
            NF +  +D+  F YR++++ +    +  + ++LD+I E   E AE           L+  ++ E+                   +CLQ         + +   +   D++    +     +E  F  R     ++ R + S  +G+++  + +V + + V+  +  + + C        ++  + T+L   +T  N   +      L  +   S Y   Q   IQE+ +  P G +PR+  V CV A+  L   V+PGD V I GVF  L N        G+ +  F     IN I         E IP  E +       + K ++P  + L+ARS+AP I GHE+ KK LL +++ G   I   G+++RG +N+ L+GDP VAKSQLL +V R+ PR+  T GRGSSG GLTA+V  D  +GE  LEAG++VLAD G+ CIDEFDKM+D DRTAIHEVMEQ  ++I+KAGI   LNAR S+LAAANP YGRYNP ++  +NI +  +LLSRFDL++++ D+ D D D  +A+H+  +H   T  EA  +VL    G                         AG+     L+M  +R+Y+ + RS   P + +    Y+   Y  +R    +K   + ++  +AR L  LIR+STA+++ +   +V+R D ++A  LL
Sbjct:   27 NFLDNQADT--FHYRQKIVKMMNDGESRLVMNLDEIREILPERAE----------GLLTQSVLEM-------------------NCLQ---------SALQMAINRSDVQAVVKTGFHVGFEGTFGERH----VNPRTLKSSYLGNLVCCEGIVTKCSTVRQKLLTSVHYCPATNKVLEKKFADFTMLDTAVTNNNYPTEDENKNPLETEFGHSVYKDHQTFTIQELPESAPAGQLPRA--VDCV-ADLDLADRVKPGDRVRIIGVFRVLPNK-----QNGVSSGSFRSIIIINHIQMLSK----EVIPNFEPQDVKDVRKISKSRNP--FELLARSLAPSICGHEETKKALLCLLLGGMEKILNNGSRLRGDINVLLIGDPSVAKSQLLRYVLRMAPRAITTTGRGSSGVGLTAAVTTDPDSGERRLEAGAMVLADRGVVCIDEFDKMSDIDRTAIHEVMEQGRVTISKAGIHAKLNARCSVLAAANPVYGRYNPFKSPMENIGMQDSLLSRFDLIFVLLDEHDADKDANVAEHVLKLHTYRTQGEADGTVLPMGGGVETISTINMETKKASSSIYEENTQWAGIQDTKILTMDFMRKYIHLARSV-QPKLTDEATEYISEVYADIRSFDITKTDQERTMPVTARQLETLIRLSTAIAKARFSKKVEREDTEKAYNLL 646          

Query:   55 KFKNFIENFYEETSDSKKFIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRAT--VNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGS------ETFQEILNKTLLPLLTCTNEVCKIGTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKLKDPEMYSLMARSIAPEIFGHEDVKKGL-LXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDS---------AGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLL 1983
            +FKNF+ +F+E  +   K+I  + + +++   ++++ +S  D+++ + E           Y   +  A +E++  M RA   V    +  +   C +I+         I Q    ED+R      +LR+                       +  +I+   VV  A+ + P + +  Y C  CG       +   E +  T+ P  +C  +       G   L  + + Y   Q I +QE  ++V  G +PRS +V  +G      +PGD + +TGV+    +  +       V    + A+ I    K  SD L  T    +A  E  +DP +   +  SIAP I+GH+DVK+ + L +  G A    A  ++RG +N+ L GDPG AKSQ L +   + PRS  T G+G+S  GLTA V R  +T E TLEAG++VLAD G+C IDEFDKM+D DRT+IHE MEQQ+ISI+KAGI+T+L+AR +++AA+NP  GRYNP RT  +N+DL   +LSRFD+L +I+D  D   D RLA+ +   H  +  P +      GD           G+  +    LR+Y+   R +  P +PE         +  MRKES A    S+  + R + ++IR+S A +++  ++ V+  D   AIR++
Sbjct:  171 RFKNFLRSFHEPGNKQTKYI--QMIKSMAADNRESLEVSFTDLSDDNGE-------QNISY--FLPEAPNEMLAIMDRAATEVVMNMYPFYSRVCNEIKVR-------ISQLPVEEDIR------MLRQVH---------------------LNMLIRTAGVVTIASGILPQLAVVKYDCVACGYLLGPFVQQNDEEVRPTICP--SCQGK-------GPFELNVENTVYHNYQRITMQESPNKVAAGRLPRSKDVILLGDLCDSCKPGDEIEVTGVYTNNFDGSLNYKQGFPVFNTLIHANHITNKDKMASDQL--TDEDIKAIRELSQDPNISQRVFSSIAPSIYGHDDVKRAIALALFRGEAKNPGAKHRLRGDINVLLCGDPGTAKSQFLRYAAHIAPRSVLTTGQGASAVGLTAYVQRHPVTREWTLEAGAMVLADKGVCLIDEFDKMSDQDRTSIHEAMEQQSISISKAGIVTSLHARCTVIAASNPIGGRYNPTRTFAENVDLTEPILSRFDVLCVIRDSVDSVEDERLAKFVVGNHRTHH-PDAKKIVKEGDELEEDQMDERTGVRLIPQDLLRKYIIYAREKCHPTLPEQHSEKFSNIFAQMRKESMATG--SVAITVRHVESMIRLSEAHAKLHLRSYVNDEDCAAAIRVM 772          

Query:   31 RNYESDKDKFKNFIENFYEETSDSKK-FIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRATVN-KTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIGTAG-RLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKLKDPEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKSDRARQRTRL-GYKELIYQAIRGLAADSSTVRMADISKKCVSMGFTPDQINEVIDSYEELNIWQVNVGRTRIVLV 2229
            R+Y  D++  K F+  F +   D KK F+Y  Q++ ++ +EQ  I I LDD+ EF+  LAE +  N  RY  +    I E++    +  V+ K A D++I+H L +E   R+       P+   D R  FPSEL++R+E  F    T KA SIR V ++ +G ++ ++ +V R T VKP+M +ATYTCDRCGSET+Q + + +  P+  C ++ C++  AG RL+LQT+GSK+VK QE+++QE SDQVP+G+IPRSM + C G  TR+ QPGDH+ ++GVFLPL+ TG   + +GL++E FL AH I  I K++     +     E   E  +D + Y  +A S+APEI+GH DVKK LL+++ GG      G KIRG++NICLMGDPGVAKSQLLG++ RL  RSQYT GRGSSG GLTA+V++D LTGEMTLE G+LVLAD G+CCIDEFDKM D DRTAIHEVMEQQTISIAKAGIMTTLNAR SILAAANPA+GRYNPRRT+EQNI LPAALLSRFDLLWLIQDKPDRD DLRLA+HI+YVH++++ PP+ +            L M  +RRY+ + + + +P +P+ L +Y+VG Y+ +R+E++   K+  FTSAR+LL ++R+STAL+R++    V++ DV EA+RLLE SK S+      Q+  +    + I+  +R LA     V+++DI  +C + GF PDQ+++ ID YEELN+WQVN+GRT+I  +
Sbjct:    4 RDYAQDRESIKTFLSEFCKCDDDGKKEFVYGSQLVKLAHREQVLITIDLDDLAEFNESLAEAVVDNCRRYTSIFSDVIAELLPSYKQQEVHAKDALDVYIEHRLMMESRTRN-------PMEQRDERNSFPSELMKRFEVGFKPLSTEKAHSIREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTCDRCGSETYQPVNSLSFTPVHDCPSDDCRVNKAGGRLYLQTRGSKFVKFQEVKMQEHSDQVPVGHIPRSMTIMCRGEVTRMAQPGDHIVVSGVFLPLMRTGFAQMIQGLLSETFLQAHRIICINKNDEISDKDAELTPEELEELAQD-DFYERLATSLAPEIYGHLDVKKALLLLLVGGVDKRPDGMKIRGNINICLMGDPGVAKSQLLGYISRLAVRSQYTTGRGSSGVGLTAAVMKDPLTGEMTLEGGALVLADQGVCCIDEFDKMADQDRTAIHEVMEQQTISIAKAGIMTTLNARVSILAAANPAFGRYNPRRTVEQNIQLPAALLSRFDLLWLIQDKPDRDNDLRLAKHITYVHSHSKQPPTRVKA----------LDMNLMRRYINLCKRK-NPTIPDELTDYIVGAYVELRREAR-NQKDMTFTSARNLLGILRLSTALARLRLSDSVEKDDVAEALRLLEMSKDSLNQIHEHQKGHVPNTSDRIFAIVRELAGSGKAVKISDIMDRCTTKGFKPDQVDKCIDDYEELNVWQVNMGRTKITFM 720          

Query:   49 KDKFKNFIENFYE---------ETSDSKKFIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIGTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVF--LPLLNTGMRTLNRGLVTELFLDAHF----INRITKDESDDLGETIPATEAELEKL--KDPEMYSLMARSIAPEIFGHEDVKKGLLXXX---XXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHIS--YVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRL 1980
            K KFK+FI  F +         E  D  + +Y +++  I   E+  + ++   +  FD +L          Y++LICY   E+I G   A +N+  F+                               ++P+ LL  ++         K  ++R++  ++M  +I +  +VIR++ V P M+ A ++C+ C   T  E+    +     CTN  C      RL +  + S++   Q +++QE  D +  G  P ++ ++        VQPGD V +TG++   PL   G+ +  + +        HF      R+ +DE +      P    EL +L  K P++Y  +AR+IAP I+ ++D+KKG+L+ +                R  +++ L GDPG +KSQ+L +V  L PRSQYT+GRGSS  GLTA V +D  T ++ L+ G+LVLAD G+CCIDEFDKM DS R+ +HEVMEQQT+SIAKAGI+  LNAR SILAAANPA  ++N R+ I  N+ LP  LLSRFDL++L+ D  D   D RLA H+   Y  T +E   ++               M+ LR Y+A  R    P + +     L+  Y+ MRK      + S +   R L +LIR+S A ++++   +V+ +DV+EA RL
Sbjct:  165 KSKFKSFIMRFIDPSAEQDEISENIDVNQPLYLQKLEEIHTLEEPYLNLNCAHLKTFDQDL----------YRQLICYP-QEVIPGFDMA-INEMFFE-------------------------------RYPAALLE-HQIQVRPFNADKTRNMRSLNPEDMDQLISISGMVIRSSNVIPEMREAFFSCNICSFSTTVEVDRGRINQPTLCTN--CNTNHCFRL-IHNR-SEFTDKQLVKLQESPDDMAAGQTPHNVLLYAHNDLVDKVQPGDRVTVTGIYRATPLKTGGLSSSVKSVYKTHVDVVHFRKVDNKRLYEDE-EGKDHIFPPERVELLQLLAKKPDIYDRLARAIAPSIYENDDIKKGILLQLFGGTKKKHATLGRQNFRSEIHLLLCGDPGTSKSQMLQYVFNLVPRSQYTSGRGSSAVGLTAYVTKDPETRQLVLQTGALVLADNGVCCIDEFDKMNDSTRSVLHEVMEQQTLSIAKAGIICQLNARTSILAAANPAESQWNKRKNIIDNVQLPHTLLSRFDLIFLVLDPQDEIFDKRLASHLVSLYYVTRHEEEDTM-------------FDMSVLRDYIAYAREHLSPTLSDEAQQRLIQAYVDMRKVGAGRGQISAY--PRQLESLIRLSEAHAKVRLSNQVELLDVEEAWRL 766          

Query:   49 KDKFKNFIENFYE---------ETSDSKKFIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIGTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVF--LPLLNTGMRTLNRGLVTELFLDAHF----INRITKDESDDLGETIPATEAELEKL--KDPEMYSLMARSIAPEIFGHEDVKKGLLXXX---XXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHIS--YVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRL 1980
            K KFK+FI  F +         E  D  + +Y +++  I   E+  + ++   +  FD +L          Y++LICY   E+I G   A +N+  F+                               ++P+ LL  ++         K  ++R++  ++M  +I +  +VIR++ V P M+ A ++C+ C   T  E+    +     CTN  C      RL +  + S++   Q +++QE  D +  G  P ++ ++        VQPGD V +TG++   PL   G+ +  + +        HF      R+ +DE +      P    EL +L  K P++Y  +AR+IAP I+ ++D+KKG+L+ +                R  +++ L GDPG +KSQ+L +V  L PRSQYT+GRGSS  GLTA V +D  T ++ L+ G+LVLAD G+CCIDEFDKM DS R+ +HEVMEQQT+SIAKAGI+  LNAR SILAAANPA  ++N R+ I  N+ LP  LLSRFDL++L+ D  D   D RLA H+   Y  T +E   ++               M+ LR Y+A  R    P + +     L+  Y+ MRK      + S +   R L +LIR+S A ++++   +V+ +DV+EA RL
Sbjct:  165 KSKFKSFIMRFIDPSAEQDEISENIDVNQPLYLQKLEEIHTLEEPYLNLNCAHLKTFDQDL----------YRQLICYP-QEVIPGFDMA-INEMFFE-------------------------------RYPAALLE-HQIQVRPFNADKTRNMRSLNPEDMDQLISISGMVIRSSNVIPEMREAFFSCNICSFSTTVEVDRGRINQPTLCTN--CNTNHCFRL-IHNR-SEFTDKQLVKLQESPDDMAAGQTPHNVLLYAHNDLVDKVQPGDRVTVTGIYRATPLKTGGLSSSVKSVYKTHVDVVHFRKVDNKRLYEDE-EGKDHIFPPERVELLQLLAKKPDIYDRLARAIAPSIYENDDIKKGILLQLFGGTKKKHATLGRQNFRSEIHLLLCGDPGTSKSQMLQYVFNLVPRSQYTSGRGSSAVGLTAYVTKDPETRQLVLQTGALVLADNGVCCIDEFDKMNDSTRSVLHEVMEQQTLSIAKAGIICQLNARTSILAAANPAESQWNKRKNIIDNVQLPHTLLSRFDLIFLVLDPQDEIFDKRLASHLVSLYYVTRHEEEDTM-------------FDMSVLRDYIAYAREHLSPTLSDEAQQRLIQAYVDMRKVGAGRGQISAY--PRQLESLIRLSEAHAKVRLSNQVELLDVEEAWRL 766          

Query:   58 FKNFIENFYEETSDSKKFIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIGTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITG--VFLP----LLNTGMRTLNR-------------GL----VTELFLDAHFINRITKDESDDLGET-IPATE------------AELEKL----KDPEMYSLMARSIAPEIFGHEDVKKG-LLXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIF-TSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEAS 1992
            F++F+E F E+     +  Y     ++   ++  + +S +D+ ++D  LA  I +  +     +C ++   +         K  +  F                            T+ P+    R++             +R++ + ++G++I++   V+R   V P +    + C  C +E               C N VC      R  L  + S ++  Q+IRIQE   ++P G IPR++ +         VQ GD    TG  + +P    L   G R  N              GL    + EL     F+    +  +   G T +P +E            AE  K+    KD  +Y  +  S+ P I+G+++VK+G LL    G A      T +RG +N+C++GDP  AKSQ L  V    PR+ YT+G+ SS AGLTA+VVRD+ + +  +EAG+L+LAD GICCIDEFDKM   D+ AIHE MEQQTISIA+AG+  TLNAR SILAAANP  GRY+  ++++QNI L A ++SRFDL +++ D+ +   D  +A+ I  +H+N E       T              E+ RY+   R Q  P + +   + LV  Y  +R+     S  S +  + R L ++IR+S A+++++C   V    V EA RLL  S
Sbjct:   25 FQDFLEEFKED----GEIKYTRPAASLESPDRCTLEVSFEDVEKYDQNLATAIIEEYYHIYPFLCQSVSNYVKDRIGLKTQKDCYVAF----------------------------TEVPT----RHK-------------VRDLTTSKIGTLIRISGQVVRTHPVHPELVSGVFMCLDCQTEIRNVEQQFKFTNPTICRNPVC--SNRKRFMLDVEKSLFLDFQKIRIQETQAELPRGCIPRAVEIILRSELVETVQAGDRYDFTGTLIVVPDVSVLAGVGTRAENSSRHKPGEGMDGVTGLKALGMRELNYRMAFLACSVQATTARFGGTDLPMSEVTAEDMKKQMTDAEWHKIYEMSKDRNLYQNLISSLFPSIYGNDEVKRGILLQQFGGVAKTTTEKTSLRGDINVCIVGDPSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGICCIDEFDKMDQRDQVAIHEAMEQQTISIARAGVRATLNARTSILAAANPINGRYDRSKSLQQNIQLSAPIMSRFDLFFILVDECNEVVDYAIARKIVDLHSNIEESVERAYT------------REEVLRYVTFAR-QFKPVISQEAGHMLVENYGHLRQRDTGTSGRSTWRITVRQLESMIRLSEAMAKLECSNRVLERHVKEAFRLLNKS 647          

Query:  478 SIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLT--CTNEVCKIGTAGR-------LHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVF------LPLLNTGMRTLNRGL------VTELFLD---AHFINRITKDESDDLGETIPATEAELEKLK-DPEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXXXXTKIR-GSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVH-TNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKE-------SIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEAS 1992
            +IR + S  +  ++K+  +++ A+ +       +  C  C +     I N  + P L        C    AGR         +     K V  Q +++QE+ D VP G IPR + + C  +    V PG+ V I G++       P    G      G+      V  + +D   A  I+R +   SD+        E    ++    ++Y  +++S+AP IFG  D+KK +  M+ GG+         R G +N+ L+GDPG AKSQLL FV+++ P + YT+G+GSS AGLTASV++D  T    +E G++VLADGG+ CIDEFDKM + DR AIHE MEQQTISIAKAGI TTLN+R S+LAAAN  +GR++  +  E+NID    +LSRFD++++++D  D   D+ LA+HI  VH ++N++ PS    A G+      +S++  ++Y+   R+   P + E     L   Y+ MR  S AG +E       SI  + R L A+IRIS +L++I+ Q       V+EA+RL + S
Sbjct:  131 NIRQLKSDCVSKLVKIAGIIVAASGISAKATRMSIQCLSCSTV----IPNLKVNPGLEGYALPRKCNTEQAGRPKCPLDPFFIMPDKCKCVDFQTLKLQELPDFVPQGEIPRHLQLFCDRSLCERVVPGNRVLIQGIYSIRKVGKPSRRDGREKAVVGVRAPYMRVVGITVDSEGAGAISRYSNITSDE--------EEHFRRMAASGDIYERLSQSLAPSIFGSRDIKKAITCMLFGGSRKRLPDGLCRRGDINVLLLGDPGTAKSQLLKFVEKVAPIAVYTSGKGSSAAGLTASVMKDPQTRNFVMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDDTKG-EENIDFMPTILSRFDMIFIVKDIHDESRDITLAKHIINVHLSSNKSAPS--EPAEGE------ISLSTFKKYIHYCRTHCGPRLSEAAGEKLKSRYVLMR--SGAGQQEKASDKRLSIPITVRQLEAVIRISESLAKIRLQPFATDEHVNEALRLFQVS 646          

Query:  295 VNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIG-TAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKLKDPEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQ----NIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKSDRARQRTRLGYKELIYQAIRGLAADSS--TVRMADISKKCVSMGFTPDQINEVIDSYEELNIWQVNVGRTRIVLV 2229
            V K A D++I+H L +E   RD A+         D R ++P EL+RR+E YF    T K   +R+V +  +G ++ ++ +V RAT VKP+M +ATYTCD+CG+ET+Q I + +  PL+ C ++ C    + GRL+LQT+GSK++K QE+RIQE SDQVP+GNIPRSM ++  G NTR+ QPGDHV ++GVFLPLL +G R   +GL++E +L+ H I  + K E D+LG T   ++ EL ++ + + Y  +A SIAPEI+GHEDVKK LL+++ GG      G KIRG++NICLMGDPGVAKSQLL ++DRL PRSQYT GRGSSG GLTA+V+RD +TGEMTLE G+LVLAD G+CCIDEFDKM D+DRTAIHEVMEQQTISIAK      ++   S      P+Y   + R  + Q     ++L +++    D                     S  H  N     V   A              +RRY++  + Q  P VPE+L +Y+   Y+ MRKE++  SK++ FTSAR+LL+++R+STAL+R++  + V++ DV+EA+RL+E SK S+++DR+         ++I+  +R L  +S+  +VR++   ++CVS GFTP Q    +  YEELN+WQ+N  RTRI  V
Sbjct:    3 VVKDALDVYIEHRLMMEVRGRDPAD-------TRDHRKQYPPELMRRFEVYFRPPATLKPRVVRDVKADSIGQLVTVRGIVTRATEVKPMMAVATYTCDQCGAETYQPIASPSFTPLIMCPSQECVTNKSGGRLYLQTRGSKFIKFQELRIQEHSDQVPVGNIPRSMTIYARGENTRVAQPGDHVAVSGVFLPLLRSGFRQAVQGLLSETYLECHSITLMNKTEDDELG-TEELSDEELRQITEEDFYEKLAGSIAPEIYGHEDVKKALLLLLVGGVEQAPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVMRDPVTGEMTLEGGALVLADLGVCCIDEFDKMADADRTAIHEVMEQQTISIAK------VSPACSCPHPHCPSYMPGSSRVCVFQAGIMTVELSSSMHQEID---------------------SQNHLKNCMYLCVRACAC---------VCVRVRRYISKCK-QKQPVVPESLSDYITAAYVEMRKEARV-SKDTTFTSARTLLSILRLSTALARLRMVSVVEKEDVNEAMRLMEMSKDSLQADRSSSSRSQRPADVIFSLLRELCGESAGRSVRVSAAEQRCVSRGFTPAQFQAALQEYEELNVWQINQARTRITFV 608          

Query:  295 VNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIG-TAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKLKDPEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAAN 1503
            V K A D++I+H L +E   RD A+         D R ++P EL+RR+E YF    T K   +R+V +  +G ++ ++ +V RAT VKP+M +ATYTCD+CG+ET+Q I + +  PL+ C ++ C    + GRL+LQT+GSK++K QE+RIQE SDQVP+GNIPRSM ++  G NTR+ QPGDHV ++GVFLPLL +G R   +GL++E +L+ H I  + K E D+LG T   ++ EL ++ + + Y  +A SIAPEI+GHEDVKK LL+++ GG      G KIRG++NICLMGDPGVAKSQLL ++DRL PRSQYT GRGSSG GLTA+V+RD +TGEMTLE G+LVLAD G+CCIDEFDKM D+DRTAIHEVMEQQTISIAKAGIMT+LNAR SILAAAN
Sbjct:    2 VVKDALDVYIEHRLMMEVRGRDPAD-------TRDHRKQYPPELMRRFEVYFRPPATLKPRVVRDVKADSIGQLVTVRGIVTRATEVKPMMAVATYTCDQCGAETYQPIASPSFTPLIMCPSQECVTNKSGGRLYLQTRGSKFIKFQELRIQEHSDQVPVGNIPRSMTIYARGENTRVAQPGDHVAVSGVFLPLLRSGFRQAVQGLLSETYLECHSITLMNKTEDDELG-TEELSDEELRQITEEDFYEKLAGSIAPEIYGHEDVKKALLLLLVGGVEQAPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVMRDPVTGEMTLEGGALVLADLGVCCIDEFDKMADADRTAIHEVMEQQTISIAKAGIMTSLNARCSILAAAN 397          

Query:   49 KDKFKNFIENFYEETS--------DSKKFIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIGTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVF--LPL-LNTGMRTLNRGLVTELFLDA-HFINRITKDES----DDLGETIPATEAELEKLKD----PEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXXXXT---KIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTS-ARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLL-EASKASVKSDR 2016
            K+KF+ F++ F +  S        D  + +Y +++  IS   +  + ++   I  FD++L          Y++LICY   E+I      +VN+  FD F D  L+ +  +R                          Y A        K  ++RN+  +++  +I +  +VIR + + P M+ A + C  C   T  E+    +     C N  C   T   + L    S +   Q I++QE  + +P G  P +  V+        VQPGD V ITG++   P+ LN   R      V +  +DA HF  R T ++     D+ GE    T+  +  LK+    P++Y  ++ ++AP I+ HED+KKG+L+ + GG   D   T     R  +NI L GDPG +KSQLL +V  L PR QYT+G+GSS  GLTA V++D  T ++ L+ G+LVL+D GICCIDEFDKM+D+ R+ +HEVMEQQT+SIAKAGI+  LNAR SILAAANP   ++NP++T  +NI LP  LLSRFDL++L+ D  D   D RLA H+  ++  +E           +      L MA L+ Y+A  R+   P + E     L+  Y+ MR   K GS   + ++  R L +LIR++ A ++++   +V+ IDV+EA RL  EA K S    R
Sbjct:  145 KEKFQRFLQQFTDPDSREEENAGLDLNEPLYMQKLDEISVVGEPVLNVNCTHIQTFDADL----------YRQLICYP-QEVIPTFD-MSVNELFFDRFPDSVLEHQIQVRP-------------------------YSAI-------KTRNMRNLNPEDIDQLITISGMVIRTSQLIPEMQEAFFRCQVCAFNTRVEVDRGRIAEPAVCRN--C--NTTHSMALVHNRSVFSDKQMIKLQESPEDMPAGQTPHTTVVYAHNDLVDKVQPGDRVNITGIYRAAPMRLNP--RQSQVKSVYKTHIDAIHF--RKTDEKRLHGLDEDGEQKLFTKERVALLKELAAKPDVYERLSSALAPSIYEHEDIKKGILLQLFGGTRKDFTQTGRGNFRAEVNILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMSDNTRSVLHEVMEQQTLSIAKAGIICQLNARTSILAAANPVESQWNPKKTTIENIQLPHTLLSRFDLIFLMLDPQDEAYDRRLAHHLVSLYYQSE-----------EQIEEEHLDMAVLKDYIAFARTTVHPRLSEEASQALIEAYVDMR---KIGSGRGMVSAYPRQLESLIRLAEAHAKVRFSGKVETIDVEEAKRLHREALKQSATDPR 759          

Query:   58 FKNFIENFYEETSDSKKFIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRC-GSETFQEILNKTLLPLLTCTNEVCKIGTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITG--VFLPLL-----------------------NTGMRTLNRGLVTEL-----FLDAH-------FINRITKDE---SDDLGETIPATEAE--LEKLKDPEMYSLMARSIAPEIFGHEDVKKG-LLXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIF-TSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKS 2010
            F+ F+E F     + K     E+++   + E+  + +S  D+  F+ ELA  I++  +R    +C A+       G    +K  +  F                        +DL T+                       IR + + ++GS++++   V+R   V P +   T+ C  C G     E   K   P + C N VC      R  L T  SK++  Q++RIQE   ++P G+IPRSM V          Q GD     G  + +P +                       N G+R L    V EL     FL  H       F  +  +DE   ++ + + +   E E   E  +D  +Y  +  S+ P I G+++VK+G LL++  G       GT +RG +N+C++GDP  AKSQ L  V+  CPR+ YT+G+ SS AGLTA+VVRD+ + E  +EAG+L+LAD G+CCIDEFDKM   D+ AIHE MEQQTISI KAG+  TLNAR SILAAANP  GRY+  ++++QN++L A ++SRFDL +++ D  +   D  +A+ I  +H+  E     +             S+ E+RRYL   R Q  P + +    ++V  Y  +R+   +G  +S +  + R L +LIR+S +++R+ C  EV    V EA RLL  S   V++
Sbjct:   28 FQAFLEEFQNSDGEVKYLRDAEELI---RPERNTLAVSFTDLEGFNQELATAIQEEFYRLYPYLCRAVRNFARDHGEVPTSKEFYVAF------------------------QDLPTRH---------------------KIRELTTVKVGSLVRISGQVVRTHPVHPELVSGTFLCLDCQGVIKDVEQQFKYTQPSI-CRNPVC--NNRRRFLLDTNKSKFIDFQKVRIQETQAELPRGSIPRSMEVILRAEAVESAQAGDKCDFIGSLIVVPDISQLATPGVRAETSSRTAGVQGYENEGLRGLKALGVRELSYKLAFLACHVAPTNPRFGGKEIRDEEQTAESIKKQMSVQEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGILLMLFGGVPKTTMEGTSLRGDINVCVVGDPSTAKSQFLKHVEEFCPRAVYTSGKASSAAGLTAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMETRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVSGRYDRSKSLKQNVNLTAPIMSRFDLFFILVDDCNEVTDYAIARRIVDLHSRIENSVDRV------------YSLDEIRRYLLFAR-QFKPKISKESEEFIVEQYKRLRQRDGSGVTKSAWRITVRQLESLIRLSESMARMHCCDEVQPKHVKEAFRLLNKSIIRVET 659          

Query:   49 KDKFKNFIENFYEETSDSK-KFIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRC-GSETFQEILNKTLLPLLT--CTNEVCKIGTAGRLHLQTKGSKY---------VKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDD------LGETIPATEAELEKLK-DPEMYSLMARSIAPEIFGHEDVKKGL--LXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKE-----SIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEAS 1992
            K KF+ F+  F   T  +   + YR+++       +  I + ++D+  FD +L++ + K       L+  A  E+   + R                            +G+  T++D++    S+              +   SIR++ S+++  ++K+  ++I +T V+     AT  C +C G      I N  L P L        C    AGR+        Y         V  Q  R+QE  D VP G +PR M ++C       V PG+ V + G++        +   R   T + + + ++  +  D   +       G   P  E EL  L   P +Y  +ARS+AP I+G +D+KK +  L+       +    T+ RG +N+ ++GDPG AKSQLL FV+R  P   YT+G+GSS AGLTASV+RD  T    +E G++VLADGG+ CIDEFDKM + DR AIHE MEQQTISIAKAGI TTLN+R S+LAAAN  +GR++  +  E NID    +LSRFD++++I+D  D+  D+ LA+H+  VH + +       T      G +PL  A L++Y+A  R +  P +       L   Y+ MR  +K   +E     SI  + R L A++RI+ +L+++K Q      +VDEA+RL + S
Sbjct:   33 KKKFREFLRQFRVGTDRTGFTYKYRDELKRHYTLGEYWIEVEMEDLASFDEDLSDCLYKLPAENLPLLEEAAQEVADEVTRP-------------------------RPVGEE-TVQDIQVMLKSD--------------AHPASIRSLKSEQVSRLVKIPGIIISSTAVRAK---ATRVCLQCRGCRAV--ISNIPLPPGLQGYALPRKCNTEQAGRVKCPV--DPYFIIPDRCVCVDFQTQRLQEAPDAVPHGEMPRHMQLYCDRYLCDRVVPGNRVTVMGIYSIKKVAQTKAKGRDKGTGVGIRSAYLRVVGIDVDTEGAGRGATGSVSPQEEEELRSLAASPSVYDSLARSLAPSIYGSDDLKKAIACLLFGGSRKRLPDGLTR-RGDINLLMLGDPGTAKSQLLKFVERCSPIGVYTSGKGSSAAGLTASVLRDPTTRGFVMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDDTKG-EDNIDFMPTILSRFDMIFIIKDHHDQQRDMTLARHVMNVHLSAQ-------TQTEGVEGEIPL--ATLKKYIAYSRVKCGPRLSAAAAEKLKNRYVLMRSGAKEHERETDRRVSIPITVRQLEAVVRIAESLAKMKLQPIAGEEEVDEALRLFQVS 649          

Query:   31 RNYESDKDKFKNFIENFYEETSDSKK-FIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMG-RATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIG-TAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKLKDPEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKSDRARQRTRLGYKELIYQAIRGLAAD--SSTVRMADISKKCVSMGFTPDQINEVIDSYEELNIWQVNVGRTRIVLV 2229
            R+Y+++K+K K F++ FY++    KK F Y  Q+ NI+ +EQ A+YI LDD+ E D EL + I +N  RY  L   A+ E++     R  V+K A D++I+H L +EQ  RD       P    D   ++P EL+RR+E YF A  +SKA  +R+V +  +G ++ ++ +V R T VKP+M +ATYTCD+CG+ET+Q I + T +PL+ C +  C+   + GRL+LQT+GSK++K QE++IQE SDQVP+GNIPR M+V+  G NTRL QPGDHV ITGVFLP+L TG R + +GL++E +L++H + ++ K E D+LG T   +E EL ++ + + Y  +A SIAPEI+GHEDVKK LL+++ GG      G KIRG++NICLMGDPGVAKSQLL ++DRL PRSQYT GRGSSG GLTA+V++D +TGEMTLE G+LVLAD G+CCIDEFDKM D+DRTAIHEVMEQQTISIAKAGIMTTLNAR SILAAANPAYGRYNP++T+EQNI LPAALLSRFDLLWLIQDKPDRD DLRLAQHI+YVH +++ PPS             PL M  +RRY+ + + +  PA+PE+L +YL   Y+ MRKE++  +K+  FTSAR+LL+++R+STAL+R++ +  V++ DV+EA+RL E SK S+  D+ +        ++I+  IR +  +  + +V+ ++  ++ VS GFTP Q    ++ YEELN+W VN  RT+I  V
Sbjct:    3 RDYQAEKEKCKTFLQEFYKDDELGKKNFKYGVQLANIAHREQVALYIDLDDLAEEDPELVDAICENTRRYTNLFADAVQELLPQYKEREVVHKDALDVYIEHRLMMEQRGRD-------PSETRDPHNQYPPELMRRFELYFKAPSSSKARVVRDVKADSIGKLVTVRGIVTRVTEVKPMMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSRECQTNRSGGRLYLQTRGSKFIKFQELKIQEHSDQVPVGNIPRCMSVYVRGENTRLAQPGDHVSITGVFLPMLRTGFRQVVQGLLSETYLESHRLVKMNKTEDDELG-TEELSEEELRQITEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDNSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVMKDPVTGEMTLEGGALVLADQGVCCIDEFDKMMDTDRTAIHEVMEQQTISIAKAGIMTTLNARCSILAAANPAYGRYNPKKTVEQNIQLPAALLSRFDLLWLIQDKPDRDNDLRLAQHITYVHQHSKQPPSQFQ----------PLDMKLMRRYITMCKRK-QPAIPESLADYLTAAYVEMRKEART-NKDMTFTSARTLLSILRLSTALARLRLEDVVEKEDVNEAMRLTEMSKDSLLGDKGQTSRTQRPADVIFSTIREMVPEKGARSVKYSEAEQRAVSKGFTPAQFEAALEEYEELNVWLVNQARTKITFV 720          

Query:   31 RNYESDKDKFKNFIENFYEETSDSKK-FIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMG-RATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIG-TAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKLKDPEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKSDRARQRTRLGYKELIYQAIRGLAAD--SSTVRMADISKKCVSMGFTPDQINEVIDSYEELNIWQVNVGRTRIVLV 2229
            R Y   + K K F++ FY++    KK F Y  Q+ NI+ +EQ A+YI LDD+ E D EL + I +N  RY  L   A+ E++     R  V+K A D++I+H L +EQ  RD       P    D   ++P EL+RR+E YF A  +SKA  +R+V +  +G ++ ++ +V R T VKP+M +ATYTCD+CG+ET+Q I + T +PL+ C +  C+   + GRL+LQT+GSK++K QE++IQE SDQVP+GNIPR M+V+  G NTRL QPGDHV ITGVFLP+L TG R + +GL++E +L++H + ++ K E D+LG T   +E EL ++ + + Y  +A SIAPEI+GHEDVKK LL+++ GG      G KIRG++NICLMGDPGVAKSQLL ++DRL PRSQYT GRGSSG GLTA+V++D +TGEMTLE G+LVLAD G+CCIDEFDKM D+DRTAIHEVMEQQTISIAKAGIMTTLNAR SILAAANPAYGRYNP++T+EQNI LPAALLSRFDLLWLIQDKPDRD DLRLAQHI+YVH +++ PPS             PL M  +RRY+ + + +  PA+PE+L +YL   Y+ MRKE++  +K+  FTSAR+LL+++R+STAL+R++ +  V++ DV+EA+RL E SK S+  D+ +        ++I+  IR +  +  + +V+ ++  ++ VS GFTP Q    ++ YEELN+W VN  RT+I  V
Sbjct:    4 RAYTLQEKKCKTFLQEFYKDDELGKKNFKYGVQLANIAHREQVALYIDLDDLAEEDPELVDAICENTRRYTNLFADAVQELLPQYKEREVVHKDALDVYIEHRLMMEQRGRD-------PSETRDPHNQYPPELMRRFELYFKAPSSSKARVVRDVKADSIGKLVTVRGIVTRVTEVKPMMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSRECQTNRSGGRLYLQTRGSKFIKFQELKIQEHSDQVPVGNIPRCMSVYVRGENTRLAQPGDHVSITGVFLPMLRTGFRQVVQGLLSETYLESHRLVKMNKTEDDELG-TEELSEEELRQITEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDNSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVMKDPVTGEMTLEGGALVLADQGVCCIDEFDKMMDTDRTAIHEVMEQQTISIAKAGIMTTLNARCSILAAANPAYGRYNPKKTVEQNIQLPAALLSRFDLLWLIQDKPDRDNDLRLAQHITYVHQHSKQPPSQFQ----------PLDMKLMRRYITMCKRK-QPAIPESLADYLTAAYVEMRKEART-NKDMTFTSARTLLSILRLSTALARLRLEDVVEKEDVNEAMRLTEMSKDSLLGDKGQTSRTQRPADVIFSTIREMVPEKGARSVKYSEAEQRAVSKGFTPAQFEAALEEYEELNVWLVNQARTKITFV 721          

Query:   31 RNYESDKDKFKNFIENFYEETSDSKK-FIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMG-RATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIG-TAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKLKDPEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKSDRARQRTRLGYKELIYQAIRGLAAD--SSTVRMADISKKCVSMGFTPDQINEVIDSYEELNIWQVNVGRTRIVLV 2229
            ++  S + K K F++ FY++    KK F Y  Q+ NI+ +EQ A+YI LDD+ E D EL + I +N  RY  L   A+ E++     R  V+K A D++I+H L +EQ  RD       P    D   ++P EL+RR+E YF A  +SKA  +R+V +  +G ++ ++ +V R T VKP+M +ATYTCD+CG+ET+Q I + T +PL+ C +  C+   + GRL+LQT+GSK++K QE++IQE SDQVP+GNIPR M+V+  G NTRL QPGDHV ITGVFLP+L TG R + +GL++E +L++H + ++ K E D+LG T   +E EL ++ + + Y  +A SIAPEI+GHEDVKK LL+++ GG      G KIRG++NICLMGDPGVAKSQLL ++DRL PRSQYT GRGSSG GLTA+V++D +TGEMTLE G+LVLAD G+CCIDEFDKM D+DRTAIHEVMEQQTISIAKAGIMTTLNAR SILAAANPAYGRYNP++T+EQNI LPAALLSRFDLLWLIQDKPDRD DLRLAQHI+YVH +++ PPS             PL M  +RRY+ + + +  PA+PE+L +YL   Y+ MRKE++  +K+  FTSAR+LL+++R+STAL+R++ +  V++ DV+EA+RL E SK S+  D+ +        ++I+  IR +  +  + +V+ ++  ++ VS GFTP Q    ++ YEELN+W VN  RT+I  V
Sbjct:    4 KSLHSTRKKCKTFLQEFYKDDELGKKNFKYGVQLANIAHREQVALYIDLDDLAEEDPELVDAICENTRRYTNLFADAVQELLPQYKEREVVHKDALDVYIEHRLMMEQRGRD-------PSETRDPHNQYPPELMRRFELYFKAPSSSKARVVRDVKADSIGKLVTVRGIVTRVTEVKPMMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSRECQTNRSGGRLYLQTRGSKFIKFQELKIQEHSDQVPVGNIPRCMSVYVRGENTRLAQPGDHVSITGVFLPMLRTGFRQVVQGLLSETYLESHRLVKMNKTEDDELG-TEELSEEELRQITEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDNSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVMKDPVTGEMTLEGGALVLADQGVCCIDEFDKMMDTDRTAIHEVMEQQTISIAKAGIMTTLNARCSILAAANPAYGRYNPKKTVEQNIQLPAALLSRFDLLWLIQDKPDRDNDLRLAQHITYVHQHSKQPPSQFQ----------PLDMKLMRRYITMCKRK-QPAIPESLADYLTAAYVEMRKEART-NKDMTFTSARTLLSILRLSTALARLRLEDVVEKEDVNEAMRLTEMSKDSLLGDKGQTSRTQRPADVIFSTIREMVPEKGARSVKYSEAEQRAVSKGFTPAQFEAALEEYEELNVWLVNQARTKITFV 721          

Query:   55 KFKNFIENFYEETSDSKK-FIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMG-RATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIG-TAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKLKDPEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKSDRARQRTRLGYKELIYQAIRGLAAD--SSTVRMADISKKCVSMGFTPDQINEVIDSYEELNIWQVNVGRTRIVLV 2229
            K K F++ FY++    KK F Y  Q+ NI+ +EQ A+YI LDD+ E D EL + I +N  RY  L   A+ E++     R  V+K A D++I+H L +EQ  RD       P    D   ++P EL+RR+E YF A  +SKA  +R+V +  +G ++ ++ +V R T VKP+M +ATYTCD+CG+ET+Q I + T +PL+ C +  C+   + GRL+LQT+GSK++K QE++IQE SDQVP+GNIPR M+V+  G NTRL QPGDHV ITGVFLP+L TG R + +GL++E +L++H + ++ K E D+LG T   +E EL ++ + + Y  +A SIAPEI+GHEDVKK LL+++ GG      G KIRG++NICLMGDPGVAKSQLL ++DRL PRSQYT GRGSSG GLTA+V++D +TGEMTLE G+LVLAD G+CCIDEFDKM D+DRTAIHEVMEQQTISIAKAGIMTTLNAR SILAAANPAYGRYNP++T+EQNI LPAALLSRFDLLWLIQDKPDRD DLRLAQHI+YVH +++ PPS             PL M  +RRY+ + + +  PA+PE+L +YL   Y+ MRKE++  +K+  FTSAR+LL+++R+STAL+R++ +  V++ DV+EA+RL E SK S+  D+ +        ++I+  IR +  +  + +V+ ++  ++ VS GFTP Q    ++ YEELN+W VN  RT+I  V
Sbjct:   10 KCKTFLQEFYKDDELGKKNFKYGVQLANIAHREQVALYIDLDDLAEEDPELVDAICENTRRYTNLFADAVQELLPQYKEREVVHKDALDVYIEHRLMMEQRGRD-------PSETRDPHNQYPPELMRRFELYFKAPSSSKARVVRDVKADSIGKLVTVRGIVTRVTEVKPMMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSRECQTNRSGGRLYLQTRGSKFIKFQELKIQEHSDQVPVGNIPRCMSVYVRGENTRLAQPGDHVSITGVFLPMLRTGFRQVVQGLLSETYLESHRLVKMNKTEDDELG-TEELSEEELRQITEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDNSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVMKDPVTGEMTLEGGALVLADQGVCCIDEFDKMMDTDRTAIHEVMEQQTISIAKAGIMTTLNARCSILAAANPAYGRYNPKKTVEQNIQLPAALLSRFDLLWLIQDKPDRDNDLRLAQHITYVHQHSKQPPSQFQ----------PLDMKLMRRYITMCKRK-QPAIPESLADYLTAAYVEMRKEART-NKDMTFTSARTLLSILRLSTALARLRLEDVVEKEDVNEAMRLTEMSKDSLLGDKGQTSRTQRPADVIFSTIREMVPEKGARSVKYSEAEQRAVSKGFTPAQFEAALEEYEELNVWLVNQARTKITFV 719          

Query:   55 KFKNFIENFYEETSDSKK-FIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMG-RATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIG-TAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKLKDPEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKSDRARQRTRLGYKELIYQAIRGLAAD--SSTVRMADISKKCVSMGFTPDQINEVIDSYEELNIWQVNVGRTRIVLV 2229
            K K F++ FY++    KK F Y  Q+ NI+ +EQ A+YI LDD+ E D EL + I +N  RY  L   A+ E++     R  V+K A D++I+H L +EQ  RD       P    D   ++P EL+RR+E YF A  +SKA  +R+V +  +G ++ ++ +V R T VKP+M +ATYTCD+CG+ET+Q I + T +PL+ C +  C+   + GRL+LQT+GSK++K QE++IQE SDQVP+GNIPR M+V+  G NTRL QPGDHV ITGVFLP+L TG R + +GL++E +L++H + ++ K E D+LG T   +E EL ++ + + Y  +A SIAPEI+GHEDVKK LL+++ GG      G KIRG++NICLMGDPGVAKSQLL ++DRL PRSQYT GRGSSG GLTA+V++D +TGEMTLE G+LVLAD G+CCIDEFDKM D+DRTAIHEVMEQQTISIAKAGIMTTLNAR SILAAANPAYGRYNP++T+EQNI LPAALLSRFDLLWLIQDKPDRD DLRLAQHI+YVH +++ PPS             PL M  +RRY+ + + +  PA+PE+L +YL   Y+ MRKE++  +K+  FTSAR+LL+++R+STAL+R++ +  V++ DV+EA+RL E SK S+  D+ +        ++I+  IR +  +  + +V+ ++  ++ VS GFTP Q    ++ YEELN+W VN  RT+I  V
Sbjct:   14 KCKTFLQEFYKDDELGKKNFKYGVQLANIAHREQVALYIDLDDLAEEDPELVDAICENTRRYTNLFADAVQELLPQYKEREVVHKDALDVYIEHRLMMEQRGRD-------PSETRDPHNQYPPELMRRFELYFKAPSSSKARVVRDVKADSIGKLVTVRGIVTRVTEVKPMMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSRECQTNRSGGRLYLQTRGSKFIKFQELKIQEHSDQVPVGNIPRCMSVYVRGENTRLAQPGDHVSITGVFLPMLRTGFRQVVQGLLSETYLESHRLVKMNKTEDDELG-TEELSEEELRQITEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDNSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVMKDPVTGEMTLEGGALVLADQGVCCIDEFDKMMDTDRTAIHEVMEQQTISIAKAGIMTTLNARCSILAAANPAYGRYNPKKTVEQNIQLPAALLSRFDLLWLIQDKPDRDNDLRLAQHITYVHQHSKQPPSQFQ----------PLDMKLMRRYITMCKRK-QPAIPESLADYLTAAYVEMRKEART-NKDMTFTSARTLLSILRLSTALARLRLEDVVEKEDVNEAMRLTEMSKDSLLGDKGQTSRTQRPADVIFSTIREMVPEKGARSVKYSEAEQRAVSKGFTPAQFEAALEEYEELNVWLVNQARTKITFV 723          

Query:   28 MRNYESDKDKFKNFIENFYEETSDSKK-FIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMG-RATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIG-TAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKLKDPEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKSDRARQRTRLGYKELIYQAIRGLAADSSTVRMADISKKCVSMGFTPDQINEVIDSYEELNIWQVNVGRTRIVLV 2229
            +++Y  +K+K K F++ FY E    KK F Y  Q+++++ +EQ A+Y+ LDDI E D EL + I +N  RY +L    + E++     +  VNK   D++I+H L +EQ  RD       P  + + + ++PSEL+RR+E YF    +SK   IR V +  +G ++ ++ +V R + VKP M +ATYTCD+CG+ET+Q I + T +PL+ C ++ C+   + GRL+LQT+GSK+VK QE++IQE SDQVP+GNIPRS+ V   G NTR+ QPGDHV +TG+FLP+L TG + + +GL++E +L+AH+I ++TK + D  G    ++E EL+++ + + Y  +A SIAPEI+GHEDVKK LL+++ GG      G KIRG+++ICLMGDPGVAKSQLL ++DRL PRSQYT GRGSSG GLTA+V+RD ++GE+TLE G+LVLAD G+CCIDEFDKM ++DRTAIHEVMEQQTISIAKAGI+TTLNAR SILAAANPAYGRYNPRR++EQN+ LPAALLSRFDLLWLIQD+PDRD DLRLAQHI+YVH ++  PP          A   PL M  +RRY+A+   +  P VPE+L +Y+   Y+ MR+E++A SK++ +TSAR+LLA++R+STAL+R++    V++ DV+EAIRL+E SK S+  ++ +        ++I+  IR L +   +V  ++  ++C+S GFTP Q    +D YEELN+WQVN  RTRI  V
Sbjct:    3 LKDYAIEKEKVKKFLQEFYYENELGKKQFKYGTQLVHLAHREQVALYVDLDDIAEDDPELVDSICENAKRYSRLFGDVVQELLPEYKEKEVVNKDVLDVYIEHRLMMEQRSRD-------PGAVRNPQNQYPSELMRRFELYFRGPSSSKPRVIREVRADSVGKLLTVRGIVTRVSEVKPRMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSKFVKFQEMKIQEHSDQVPVGNIPRSITVVLEGENTRIAQPGDHVSVTGIFLPVLRTGFQQMAQGLLSETYLEAHWIVKMTKSDDDVSGAGELSSE-ELKQIAEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQSPQGMKIRGNIHICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNVQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPP----------AQFEPLDMKLMRRYIAMCHER-QPTVPESLADYITAAYVEMRREARA-SKDATYTSARTLLAILRLSTALARLRMVDIVEKEDVNEAIRLMEMSKDSLLGEKGQTARTQRPADVIFATIRELVSRGRSVHFSEAEQRCISRGFTPAQFQAALDEYEELNVWQVNTSRTRITFV 719          

Query:   34 NYESDKDKFKNFIENFYEETS--------DSKKFIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIGTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPL-LNTGMRTLNRGLVTELFLDA-HFINRITK--DESDDLGETIPATEAELEKLKD----PEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXXXXT---KIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTS-ARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLL-EASKASVKSDR 2016
            N  + K+ F+ F++ F +  +        D  + +Y +Q+  I+   +  + ++ + I  F   L          Y++LI Y   E+I     A VN+  FD + D  L+ +  +R                              F A KT    S+RN+  +++  +I +  +VIR + + P M+ A + C  C   T  EI    +    +C +  C   T   + L    S +   Q I++QE  + +P G  P ++ +         VQPGD V +TG++  + +    R  N   V +  +D  H+     K     D+  E    +E  ++ LK+    P++Y  +A ++AP I+ HED+KKG+L+ + GG   D + T   K R  +NI L GDPG +KSQLL +V  L PR QYT+G+GSS  GLTA V++D  T ++ L+ G+LVL+D GICCIDEFDKM +S R+ +HEVMEQQT+SIAKAGI+  LNAR S+LAAANP   ++NP++T  +NI LP  LLSRFDL++L+ D  D   D RLA H+  ++  +E           +      L MA L+ Y+A   S   P + E     L+  Y++MR   K GS   + ++  R L +LIR++ A ++++   +V+ IDV+EA RL  EA K S    R
Sbjct:  157 NVATCKENFQRFLQCFTDPLAKEEENVGIDITQPLYMQQLGEINITGEPFLNVNCEHIKSFSKNL----------YRQLISYP-QEVIPTFDMA-VNEIFFDRYPDSILEHQIQVRP-----------------------------FNALKTK---SMRNLNPEDIDQLITISGMVIRTSQLIPEMQEAFFQCQVCAHTTRVEIDRGRIAEPCSCVH--CH--TTHSMALIHNRSFFSDKQMIKLQESPEDMPAGQTPHTIVLFAHNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVSNVKSVYKTHIDVIHYRKTDAKRLHGLDEEAEQKLFSEKRVKLLKELSRKPDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLMLDPQDEAYDRRLAHHLVSLYYQSE-----------EQVEEEFLDMAVLKDYIAYAHSTIMPRLSEEASQALIEAYVNMR---KIGSSRGMVSAYPRQLESLIRLAEAHAKVRFSNKVEAIDVEEAKRLHREALKQSATDPR 776          

Query:   28 MRNYESDKDKFKNFIENFYEETSDSKK-FIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMG-RATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIG-TAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKLKD 1023
            +++Y  +K+K K F++ FY E    KK F Y  Q+++++ +EQ A+Y+ LDDI E D EL + I +N  RY +L    + E++     +  VNK   D++I+H L +EQ  RD       P  + + + ++PSEL+RR+E YF    +SK   IR V +  +G ++ ++ +V R + VKP M +ATYTCD+CG+ET+Q I + T +PL+ C ++ C+   + GRL+LQT+GSK+VK QE++IQE SDQVP+GNIPRS+ V   G NTR+ QPGDHV +TG+FLP+L TG + + +GL++E +L+AH+I ++TK + D  G    ++E EL+++ D
Sbjct:    3 LKDYAIEKEKVKKFLQEFYYENELGKKQFKYGTQLVHLAHREQVALYVDLDDIAEDDPELVDSICENAKRYSRLFGDVVQELLPEYKEKEVVNKDVLDVYIEHRLMMEQRSRD-------PGAVRNPQNQYPSELMRRFELYFRGPSSSKPRVIREVRADSVGKLLTVRGIVTRVSEVKPRMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSKFVKFQEMKIQEHSDQVPVGNIPRSITVVLEGENTRIAQPGDHVSVTGIFLPVLRTGFQQMAQGLLSETYLEAHWIVKMTKSDDDVSGAGELSSE-ELKQIAD 329          

Query: 2047 ELIYQAIRGLAADSSTVRMADISKKCVSMGFTPDQINEVIDSYEELNIWQVNVGRTRIVLV 2229
            ++I+  IR L +   +V  ++  ++C+S GFTP Q    +D YEELN+WQVN  RTRI  V
Sbjct:  329 DVIFATIRELVSRGRSVHFSEAEQRCISRGFTPAQFQAALDEYEELNVWQVNTSRTRITFV 389          

Query:   58 FKNFIENFYEETSDSKKFIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGS---ETFQEILNKTLLPLLTCTNEVCKIGTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPL-----LNT-----------------------GMRTLN-RGLVTEL-FLDAH-------FINRITKDESDDLGETIP--ATEAELEKL----KDPEMYSLMARSIAPEIFGHEDVKKG-LLXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAG-SKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEAS 1992
            F +F+E F     + K   + E+++   + E+  + +S  D+ +F+ +L+  I++  +R    +C A+   +         K  +  F                        +DL T+                       IR + S  +G + ++   V+R   V P +   T+ C  C +   +  Q+   K   P + C N VC      R  L T  S++V  Q++RIQE   ++P G+IPRS+ V          Q GD    TG  + +     L+T                       G+R L  R L   L FL  H       F  +  +DE +   E+I    T  E EK+    +D  +Y  +  S+ P I G+++VK+G LL++  G       GT +RG +N+C++GDP  AKSQ L  VD   PR+ YT+G+ SS AGLTA+VVRD+ + E  +EAG+L+LAD G+CCIDEFDKM   D+ AIHE MEQQTISI KAG+  TLNAR SILAAANP  G Y+  ++++QNI+L A ++SRFDL +++ D+ +   D  +A+ I  +H+  E     +             S+ ++RRYL   R Q  P + +   +++V  Y  +R+   +G +K S   + R L ++IR+S +++R+ C  EV    V EA RLL  S
Sbjct:   30 FLDFLEEFQGSDGEIKYLQFAEELI---RPERNTLVVSFADLEQFNQQLSTTIQEEFYRVYPYLCRALKTFVKDRKEIPFAKDFYVAF------------------------QDLPTRH---------------------KIRELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLDCQTVIKDVEQQF--KYTQPNI-CRNPVC--ANRKRFLLDTNKSRFVDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGDRCDFTGALIVVPDVSKLSTPGARAETNSRVSGADGYETEGIRGLRALGVRDLSYRLVFLACHVAPTNPRFGGKELRDE-EQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTGEGTSLRGDINVCIVGDPSTAKSQFLKHVDEFSPRAVYTSGKASSAAGLTAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDMRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVSGHYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRIEESIDRV------------YSLDDIRRYLLFAR-QFKPKISKESEDFIVEQYKRLRQRDGSGVTKSSWRITVRQLESMIRLSESMARMHCCDEVQPKHVKEAFRLLNKS 655          

Query:   58 FKNFIENFYEETSDSKKFIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGS---ETFQEILNKTLLPLLTCTNEVCKIGTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNT----------------------------GMRTLN-RGLVTEL-FLDAH-------FINRITKDESDDLGETIP--ATEAELEKL----KDPEMYSLMARSIAPEIFGHEDVKKG-LLXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAG-SKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKS 2010
            F +F+E F     + K   + E+++   + E+  + +S  D+ +F+ +L+  I++  +R    +C A+   +         K  +  F                        +DL T+                       IR + S  +G + ++   V+R   V P +   T+ C  C +   +  Q+   K   P + C N VC      R  L T  S++V  Q++RIQE   ++P G+IPRS+ V          Q GD    TG  + + +                             G+R L  R L   L FL  H       F  +  +DE +   E+I    T  E EK+    +D  +Y  +  S+ P I G+++VK+G LL++  G       GT +RG +N+C++GDP  AKSQ L  VD   PR+ YT+G+ SS AGLTA+VVRD+ + E  +EAG+L+LAD G+CCIDEFDKM   D+ AIHE MEQQTISI KAG+  TLNAR SILAAANP  G Y+  ++++QNI+L A ++SRFDL +++ D+ +   D  +A+ I  +H+  E     +             S+ ++RRYL   R Q  P + +   +++V  Y  +R+   +G +K S   + R L ++IR+S +++R+ C  EV    V EA RLL  S   V++
Sbjct:   30 FLDFLEEFQGSDGEIKYLQFAEELI---RPERNTLVVSFADLEQFNQQLSTTIQEEFYRVYPYLCRALKTFVKDRKEIPFAKDFYVAF------------------------QDLPTRH---------------------KIRELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLDCQTVIKDVEQQF--KYTQPNI-CRNPVC--ANRKRFLLDTNKSRFVDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGDRCDFTGALIVVPDVSKLSTPGARAETNSRVSGADGYETEGIRGLRALGVRDLSYRLVFLACHVAPTNPRFGGKELRDE-EQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTGEGTSLRGDINVCIVGDPSTAKSQFLKHVDEFSPRAVYTSGKASSAAGLTAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDMRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVSGHYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRIEESIDRV------------YSLDDIRRYLLFAR-QFKPKISKESEDFIVEQYKRLRQRDGSGVTKSSWRITVRQLESMIRLSESMARMHCCDEVQPKHVKEAFRLLNKSIIRVET 661          

Query:   28 MRNYESDKDKFKNFIENFYEE-TSDSKKFIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMG-RATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIG-TAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKLKDPEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKSDRARQRTRLGYKELIYQAIRGLAADSSTVRMADISKKCVSMGFTPDQINEVIDSYEELNIWQVNVGRTRIVLV 2229
            +++Y  +KDK K F++ FY++  S  K+F Y  Q++ ++ +EQ A+Y+ LDDI E D EL + I +N  RY +L   A+ E++     R  VNK   D++I+H L +EQ  RD       P      + ++P EL+RR+E YF    ++K   IR V +  +G ++ ++ +V R + VKP M +ATYTCD+CG+ET+Q I + T +PL+ C ++ C+   + GRL+LQT+GSK++K QE+++QE SDQVP+GNIPRS+ V   G NTR+ QPGDHV +TG+FLP+L TG R + +GL++E +L+AH I +++K E D+ G     T  EL ++ + + Y  +A SIAPEI+GHEDVKK LL+++ GG      G KIRG++NICLMGDPGVAKSQLL ++DRL PRSQYT GRGSSG GLTA+V+RD ++GE+TLE G+LVLAD G+CCIDEFDKM ++DRTAIHEVMEQQTISIAKAGI+TTLNAR SILAAANPAYGRYNPRR++EQNI LPAALLSRFDLLWLIQD+PDRD DLRLAQHI+YVH ++  PP          A   PL M  +RRY+A+ R +  PAVPE+L +Y+   Y+ MR+E+ A SK++ +TSAR+LLA++R+STAL+R++    V++ DV+EAIRL+E SK S+  D+ +        ++I+  +R L ++  +VR ++  ++C+S GFTP Q    +D YEELN+WQVN  RTRI  V
Sbjct:    3 LKDYVLEKDKVKKFLQEFYQDDESGKKQFKYGNQLVQLAHREQVAMYVDLDDIAEDDPELVDSICENTKRYARLFADAVQELLPQYKEREVVNKDVLDVYIEHRLMMEQRSRD-------PGAARSPQNQYPPELMRRFELYFQGPSSNKPRVIREVRADSVGKLVTVRGIVTRVSEVKPRMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSKFIKFQEMKMQEHSDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIFLPILRTGFRQMVQGLLSETYLEAHRIVKMSKSEEDESGAG-ELTREELRQITEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPP----------AQFEPLDMKLMRRYIAMCREK-QPAVPESLADYITAAYVEMRREAWA-SKDATYTSARTLLAILRLSTALARLRMVDTVEKEDVNEAIRLMEMSKDSLLGDKGQTARTQRPADVIFATVRELVSEGQSVRFSEAEQRCISRGFTPAQFQAALDEYEELNVWQVNTARTRITFV 719          

Query:   28 MRNYESDKDKFKNFIENFYEETSDSKK-FIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEII-HGMGRATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIG-TAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKLKDPEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKSDRARQRTRLGYKELIYQAIRGLAADSSTVRMADISKKCVSMGFTPDQINEVIDSYEELNIWQVNVGRTRIVLV 2229
            +++Y  +K+K K F++ FY++    KK F Y  Q++ ++ +EQ A+Y+ LDD+ E D EL + I +N  RY KL   A+ E++     R  VNK   D++I+H L +EQ  RD       P  +   + ++P+EL+RR+E YF    ++K   IR V +  +G ++ ++ +V R + VKP M +ATYTCD+CG+ET+Q I + T +PL+ C ++ C+   + GRL+LQT+GS+++K QE+++QE SDQVP+GNIPRS+ V   G NTR+ QPGDHV +TG+FLP+L TG R + +GL++E +L+AH I ++ K E D+ G     T  EL ++ + + Y  +A SIAPEI+GHEDVKK LL+++ GG      G KIRG++NICLMGDPGVAKSQLL ++DRL PRSQYT GRGSSG GLTA+V+RD ++GE+TLE G+LVLAD G+CCIDEFDKM ++DRTAIHEVMEQQTISIAKAGI+TTLNAR SILAAANPAYGRYNPRR++EQNI LPAALLSRFDLLWLIQD+PDRD DLRLAQHI+YVH ++  PPS             PL M  +RRY+A+ R +  P VPE+L +Y+   Y+ MR+E+ A SK++ +TSAR+LLA++R+STAL+R++    V++ DV+EAIRL+E SK S+  D+ +        ++I+  +R L +   +VR ++  ++CVS GFTP Q    +D YEELN+WQVN  RTRI  V
Sbjct:    3 LKDYALEKEKVKKFLQEFYQDDELGKKQFKYGNQLVRLAHREQVALYVDLDDVAEDDPELVDSICENARRYAKLFADAVQELLPQYKEREVVNKDVLDVYIEHRLMMEQRSRD-------PGMVRSPQNQYPAELMRRFELYFQGPSSNKPRVIREVRADSVGKLVTVRGIVTRVSEVKPKMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQEHSDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIFLPILRTGFRQVVQGLLSETYLEAHRIVKMNKSEDDESGAG-ELTREELRQIAEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPSQFE----------PLDMKLMRRYIAMCREK-QPMVPESLADYITAAYVEMRREAWA-SKDATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMSKDSLLGDKGQTARTQRPADVIFATVRELVSGGRSVRFSEAEQRCVSRGFTPAQFQAALDEYEELNVWQVNASRTRITFV 719          

Query:   28 MRNYESDKDKFKNFIENFYEETSDSKK-FIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMG-RATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIG-TAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKLKDPEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKSDRARQRTRLGYKELIYQAIRGLAADSSTVRMADISKKCVSMGFTPDQINEVIDSYEELNIWQVNVGRTRIVLV 2229
            +++Y  +K+K K F++ FY E    KK F Y  Q+++++ +EQ A+Y+ LDDI E D EL + I +N  RY +L    + E++     +  VNK   D++I+H L +EQ  RD       P  + + + ++PSEL+RR+E YF    +SK   IR V +  +G ++ ++ +V R + VKP M +ATYTCD+CG+ET+Q I + T +PL+ C ++ C+   + GRL+LQT+GSK+VK QE++IQE SDQVP+GNIPRS+ V   G NTR+ QPGDHV +TG+FLP+L TG + + +GL++E +L+AH+I ++TK + D  G    ++E EL+++ + + Y  +A SIAPEI+GHEDVKK LL+++ GG      G KIRG+++ICLMGDPGVAKSQLL ++DRL PRSQYT GRGSSG GLTA+V+RD ++GE+TLE G+LVLAD G+CCIDEFDKM ++DRTAIHEVMEQQTISIAKAGI+TTLNAR SILAAANPAYGRYNPRR++EQN+ LPAALLSRFDLLWLIQD+PDRD DLRLAQHI+YVH ++  PP          A   PL M  +RRY+A+   +  P VPE+L +Y+   Y+ MR+E++A SK++ +TSAR+LLA++R+STAL+R++    V++ DV+EAIRL+E SK S+  ++ +        ++I+  IR L +   +V  ++  ++C+S GFTP Q    +D YEELN+WQVN  RTRI  V
Sbjct:    3 LKDYAIEKEKVKKFLQEFYYENELGKKQFKYGTQLVHLAHREQVALYVDLDDIAEDDPELVDSICENAKRYSRLFGDVVQELLPEYKEKEVVNKDVLDVYIEHRLMMEQRSRD-------PGAVRNPQNQYPSELMRRFELYFRGPSSSKPRVIREVRADSVGKLLTVRGIVTRVSEVKPRMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSKFVKFQEMKIQEHSDQVPVGNIPRSITVVLEGENTRIAQPGDHVSVTGIFLPVLRTGFQQMAQGLLSETYLEAHWIVKMTKSDDDVSGAGELSSE-ELKQIAEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQSPQGMKIRGNIHICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNVQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPP----------AQFEPLDMKLMRRYIAMCHER-QPTVPESLADYITAAYVEMRREARA-SKDATYTSARTLLAILRLSTALARLRMVDIVEKEDVNEAIRLMEMSKDSLLGEKGQTARTQRPADVIFATIRELVSRGRSVHFSEAEQRCISRGFTPAQFQAALDEYEELNVWQVNTSRTRITFV 719          

Query:   31 RNYESDKDKFKNFIENFYEETSDSKK-FIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMG-RATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIG-TAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKLKDPEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKSDRARQRTRLGYKELIYQAIRGLAAD--SSTVRMADISKKCVSMGFTPDQINEVIDSYEELNIWQVNVGRTRIVLV 2229
            R+Y+++K+K K F++ FY++    KK F Y  Q+ NI+ +EQ A+ I LDD+ E D EL + I +N  RY  L   A+ E++     R  V+K A D++I+H L +EQ  RD       P  + D   ++P EL+RR+E YF A  +SKA  +R+V +  +G ++ ++ +V R T VKP+M +ATYTCD+CG+ET+Q I + T +PL+ C +  C+   + GRL+LQT+GSK++K QE++IQE SDQVP+GNIPR M+V+  G NTRL QPGDHV ITGVFLP+L TG R + +GL++E +L++H + ++ K E D+LG T   +E EL ++ + + Y  +A SIAPEI+GHEDVKK LL+++ GG      G KIRG++N+CLMGDPGVAKSQLL ++DRL PRSQYT GRGSSG GLTA+V++D +TGEMTLE G+LVLAD G+CCIDEFDKM DSDRTAIHEVMEQQTISIAKAGIMTTLNAR SILAAANPAYGRYNP++T+EQNI LPAALLSRFDLLWLIQDKPDRD DLRLAQHI+YVH +++ PPS             P+ M  +RRY+ + +S+  PA+PE+L +YL   Y+ MRKE++  +K+  FTSAR+LL+++R+STAL+R++ +  V++ DV+EA+RL E SK S++ D+          ++I+  IR +  +  + +V+ ++  ++CVS GFTP Q    ++ YEELN+W VN  RT+I  V
Sbjct:    3 RDYQAEKEKCKTFLQEFYKDDEFGKKNFKYGVQLANIAHREQVALCIDLDDLAEEDPELVDAICENTRRYTNLFADAVQELLPQYKEREVVHKDALDVYIEHRLMMEQRGRD-------PNEMRDPHNQYPPELMRRFELYFKAPSSSKARVVRDVKADSIGKLVTVRGIVTRVTEVKPMMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSRECQTNRSGGRLYLQTRGSKFIKFQELKIQEHSDQVPVGNIPRCMSVYVRGENTRLAQPGDHVGITGVFLPMLRTGFRQVVQGLLSETYLESHRLVKMNKTEDDELG-TEELSEEELRQITEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDHSPRGMKIRGNINVCLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVMKDPVTGEMTLEGGALVLADQGVCCIDEFDKMMDSDRTAIHEVMEQQTISIAKAGIMTTLNARCSILAAANPAYGRYNPKKTVEQNIQLPAALLSRFDLLWLIQDKPDRDNDLRLAQHITYVHQHSKQPPSQFQ----------PMDMKLMRRYITMCKSK-QPAIPESLADYLTAAYVEMRKEART-NKDMTFTSARTLLSILRLSTALARLRLEDVVEKEDVNEAMRLTEMSKDSLQGDKGHASRTQRPADVIFSTIREMVPEKGARSVKYSEAEQRCVSKGFTPAQFEAALEEYEELNVWLVNQARTKITFV 720          

Query:   31 RNYESDKDKFKNFIENFYEETSDSKK-FIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMG-RATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIG-TAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKLKDPEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKSDRARQRTRLGYKELIYQAIRGLAAD--SSTVRMADISKKCVSMGFTPDQINEVIDSYEELNIWQVNVGRTRIVLV 2229
            R+Y+++K+K K F++ FY++    KK F Y  Q+ NI+ +EQ A+YI LDD+ E D EL + I +N  RY  L   A+ E++     R  V+K A D++I+H L +EQ  RD       P  + D + ++P EL+RR+E YF A  +SKA  +R+V +  +G ++ ++ +V R T VKP+M +ATYTCD+CG+ET+Q I + T +PL+ C +  C+   + GRL+LQT+GSK++K QE++IQE SDQVP+GNIPR M+V+  G NTRL QPGDHV ITGVFLP+L TG R + +GL++E +L+ H + ++ K E D+LG T   +E EL ++ + + Y  +A SIAPEI+GHEDVKK LL+++ GG      G KIRG++NICLMGDPGVAKSQLL ++DRL PRSQYT GRGSSG GLTA+V++D +TGEMTLE G+LVLAD G+CCIDEFDKM D+DRTAIHEVMEQQTISIAKAGIMTTLNAR SILAAANPAYGRYNP++T+EQNI LPAALLSRFD+LWLIQDKPDRD DLRLAQHI+YVH +++ PPS             PL M  +RRY+ + + +  PA+PE L +YL   Y+ MRKE++  +K+  FTSAR+LL+++R+STAL+R++ +  V++ DV+EA+RL+E SK S+  D+          ++I+  IR +  +  + +V+ ++  ++CVS GFTP Q    ++ YEELN+W VN  RT+I  V
Sbjct:    3 RDYQTEKEKCKTFLQEFYKDDEIGKKHFKYGVQLANIAHREQVALYIDLDDLAEEDPELVDAICENTRRYTNLFADAVQELLPQYKEREVVHKDALDVYIEHRLMMEQRGRD-------PNEMRDSQNQYPPELMRRFELYFKAPSSSKARVVRDVKADSIGKLVNIRGIVTRVTEVKPMMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSRECQTNRSGGRLYLQTRGSKFIKFQELKIQEHSDQVPVGNIPRCMSVYVRGENTRLAQPGDHVGITGVFLPMLRTGFRQVVQGLLSETYLECHRLVKMNKSEDDELG-TEELSEEELRQITEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDNSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVMKDPVTGEMTLEGGALVLADQGVCCIDEFDKMMDTDRTAIHEVMEQQTISIAKAGIMTTLNARCSILAAANPAYGRYNPKKTVEQNIQLPAALLSRFDVLWLIQDKPDRDNDLRLAQHITYVHQHSKQPPSQFQ----------PLDMKLMRRYITMCKRK-QPAIPEALADYLTAAYVEMRKEART-NKDMTFTSARTLLSVLRLSTALARLRLEDVVEKEDVNEAMRLMEMSKDSLLGDKGHTSRTQRPADVIFSTIREMVPEKGARSVKYSEAEQRCVSKGFTPAQFEAALEEYEELNVWLVNQARTKITFV 720          

Query:   31 RNYESDKDKFKNFIENFYE-ETSDSKKFIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRAT-VNKTAFDIFIDHCLQIEQNL---------RDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCK---IGTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLL--------NTGMRTL------NRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKLKDPEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXXXXT-KIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKSDRARQRTRLG----YKELIYQAIRGL-AADSSTVRMADISKKCVSMGFTPDQINEVIDSYEELNIWQVNVGRTRIVLV 2229
            RNY+ DK     F+  F + ++S +K F+Y EQ+ N++ +EQ A+YI++DDI+EF  ELAE +E N  RYQKL    +D+++        V +   DIFIDH +++EQ +         R +A    Q + IE++R++FP ELLRR+E YF  R   K +S+R+VL+  +G +I+++ +V RAT VKPL+ IATYTC+RCG+ET+QEI N T +PL  C    CK    G  GRLHLQT+GSK+ K QEIRIQE+SDQVP+GNIPR ++++  G NTR   PGDHV ITGVFLP L        N G RT       + GL+ E +L+AH I  ++K  +D++ ET   TE E+E+L+DPE+YSLMARS+APEI+GHEDVKK LL+++ GG  +      +IRG+LN+CLMGDPGVAKSQLLGFVDRL  RSQYT GRGSSG GLTASV++D LTGEMTLE GSLVLAD G+CCIDEFDKMT+ DRTAIHEVMEQQTISIAKAGI+TTLNAR +ILAAANPAYGRYNP RT+EQNIDLPAALLSRFDLLWLIQDKP+R+ DLRLAQHI+YVH +  AP +   T+   +      ++ ELRR + I + QP P+VP  L +YLVG Y+ MRKE++  +KE  +TSAR+LLA++R+STA +R++  TEV + D+DEA+RL+EAS+AS+ S  +    R+G    YK++IY   R L  A   T R+AD+ ++C + G+TP Q+NEV+D+YE LN+WQ NVGRTR+ +V
Sbjct:    7 RNYDEDKQSISEFLRTFNKVDSSGNKHFLYSEQLTNVANREQTAVYIAVDDISEFSEELAEAVESNASRYQKLFAECVDKLLPDFRTGDLVPQDVLDIFIDHRIRMEQRVMAEDSGEVSRSAAQSRNQNVDIEEIRSRFPPELLRRFEVYFCGRIDRKPISVRSVLAASIGRLIQVRGIVTRATEVKPLISIATYTCNRCGAETYQEITNPTFMPLSLCGTSACKNAGPGGGGRLHLQTRGSKFAKFQEIRIQELSDQVPVGNIPRGLSIYLRGENTRSAMPGDHVLITGVFLPSLKHASFSGGNQGGRTAMAVNSASGGLMAETYLEAHSIQLLSK--TDEVTETGEPTEDEVERLRDPEVYSLMARSLAPEIYGHEDVKKALLLLLVGGVELAPKAGLRIRGNLNVCLMGDPGVAKSQLLGFVDRLSTRSQYTTGRGSSGVGLTASVMKDPLTGEMTLEGGSLVLADQGVCCIDEFDKMTEFDRTAIHEVMEQQTISIAKAGILTTLNARVAILAAANPAYGRYNPNRTVEQNIDLPAALLSRFDLLWLIQDKPEREHDLRLAQHITYVHMHGSAPTTTEGTSLPGAEQQNLFTLTELRRLIQIAKMQPAPSVPAHLADYLVGAYVEMRKEARV-NKEMTYTSARTLLAIMRLSTAHARLRAATEVTKSDIDEAMRLMEASRASINSTGSGDFDRVGRPQSYKDIIYHIARELTGAGGGTARLADVMERCAARGYTPLQVNEVVDAYENLNVWQTNVGRTRLTVV 770          

Query:   28 MRNYESDKDKFKNFIENFYEETSDSKK-FIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEII--HGMGRATVNKTAFDIFIDHCLQIEQNLR---------DSANGIGQPLTIE--DLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKI---GTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLN--------TGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKLKDPEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXXXXT-KIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKSDRARQRTR---LGYKELIYQAIRG-LAADSSTVRMADISKKCVSMGFTPDQINEVIDSYEELNIWQVNVGRTRIVLV 2229
             R+YE+DK +   F++ F++   D +K F Y EQ+  ++ +++  I ISLDD+ + + EL   +E N  R+Q+L   AID++I  +  G A ++    DIFIDH +++EQ +               + QP + E  ++R KFP ELLRRYE YF AR T K +S+R VL+  +G +I+++ +V R T VKPL+++ATYTCDRCG+ET+QEI + + +PL+ C    CK    G+AG+L LQT+GSK+ K QEIRIQE+SDQVP+GNIPR + V+  G NTRLVQPGDHV ITGVFLP           + M      L+ + FLDAHFI +++K ES+ L E    TEAE+E+L+DP+MYSLMA+S+APEI+GHEDVKK LL+++ GG  I      +IRG++NICLMGDPGVAKSQLLGFV RL PRSQYT GRGSSG GLTA+V +D  TGEMTLE G+LVLAD G+CCIDEFDKM + DRTAIHEVMEQQTISIAKAGI+TTLNAR ++LAAANPAYGRYNP R++EQN+DLPAALLSRFDLLWLIQD+PDR+ D+RLAQHI+YVH++  AP +   + A   A    LS+AELRR +A+ RSQP+P VP  L +YLVG Y+ MRKE++  +KE  +TSAR+LLA++R+STA +R++  +EV + D+DEA+RL+EAS+ASV +     R R   + YK+ IY  IR  L     + R+ D+ ++C + GFTP+Q+NEV+D+YE LN+WQVN+GRTRI  V
Sbjct:    6 FRDYEADKAEITRFLKEFHKSEKDGEKYFPYLEQLSKLANRKENVIRISLDDLWDMNEELTTAVEINTTRFQRLFSEAIDDLIPDYREGEAQIHDV-LDIFIDHRIRMEQRMHTEDIGGESPPQGQAVDQPNSTEMREIRAKFPPELLRRYEVYFTARSTFKPMSVRKVLASSIGHLIQVRGIVSRTTEVKPLLRVATYTCDRCGAETYQEITSSSFMPLMLCQTPACKAAGAGSAGQLQLQTRGSKFEKFQEIRIQELSDQVPVGNIPRGLTVYTHGENTRLVQPGDHVLITGVFLPSARGTVAGRAASAMSGTTGALLADTFLDAHFIIQLSKSESN-LDEE--PTEAEIERLQDPDMYSLMAQSVAPEIYGHEDVKKALLLLLVGGVEIRPQAGLRIRGNINICLMGDPGVAKSQLLGFVYRLSPRSQYTTGRGSSGVGLTAAVTKDPFTGEMTLEGGALVLADQGVCCIDEFDKMAEFDRTAIHEVMEQQTISIAKAGILTTLNARVALLAAANPAYGRYNPHRSVEQNVDLPAALLSRFDLLWLIQDRPDRENDMRLAQHIAYVHSHGSAPTNAAASDAAGHASGRLLSLAELRRLIAVARSQPEPVVPAYLADYLVGAYVEMRKEARV-NKEMTYTSARTLLAIMRLSTARARLRVASEVTKADIDEAMRLMEASRASVSNPVGGPRDRNRPVSYKDQIYAVIRELLGMGGGSTRLTDVMERCANKGFTPNQVNEVVDAYENLNVWQVNMGRTRITAV 764          

Query:   13 MKMVFMRNYESDKDKFKNFIENFYE--ETSDSKKFIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRAT-VNKTAFDIFIDHCLQIEQNLRDSANGIG--------QPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCK---IGTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLL--------------NTGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKLKDPEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXXXXT-KIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPS----VLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKS---DRARQRTRLGYKELIYQAIRGL-AADSSTVRMADISKKCVSMGFTPDQINEVIDSYEELNIWQVNVGRTRIVLV 2229
            M +  +RNY+ DK     F+  FY   ++  +K F+Y EQ+  I+ +EQ  +Y+S+DD+ E  S+LA  IE N  RY K+    ID+++        V +   DIFIDH +++EQ +R +             +P+ + ++R++FP ELLRR+E YF  R  +K L +RNVL+  +G +I+++ VV RAT VKPL+  ATYTCDRCG+ET+QEI N T +PL  C    CK    G  GRLH+QT+GSK++K QEIRIQE+SDQVP+G+IPR++ ++  G NTR  QPGDH+ +TGVFLP +              +  + T++ GL+T+ +L+AH +  ++K  +DD+ +    +E E+E+L+D E YSLMA+S+APEI+GHEDVKK LL+++ GG  +      +IRG+LNICLMGDPGVAKSQLLGFVDRL PRSQYT GRGSSG GLTASV++D LTGEMTLE G+LVLAD G+CCIDEFDKMT+ DRTAIHEVMEQQTISIAKAGI+TTLNAR +ILAAANPAYGRYNP +++EQN+DLPAALLSRFDLLWLIQDKPDR+ DLRLAQHI++VH +  AP +    + +T++ +   L  LS+ ELRR +A+ ++QP PAVP  L +YLVG Y+ MRKE++A +KE  +TSAR+LLA++R+STA +R++  +EV + D+DEA+RL+EAS+AS+ +   D  R      YK++IY  IR L AA   T R+ADI+++C + G+TP Q+NEVI++YE+LN+WQVN+GRTRI  V
Sbjct:    1 MALSTVRNYDEDKKACDQFLR-FYSKMDSCGNKHFVYSEQLTRIANREQSVLYVSIDDVAEHSSDLANAIECNAVRYTKIFAEVIDDLLPDFRTVELVPQDVLDIFIDHRIRMEQRIRAADAETAPRAVSRDPEPVNMAEVRSRFPPELLRRFEVYFCGRSDAKPLCVRNVLASSIGHLIQVRGVVTRATEVKPLITTATYTCDRCGAETYQEINNPTFMPLTVCGTAACKNAGPGGGGRLHMQTRGSKFLKFQEIRIQELSDQVPVGHIPRALTIYLRGENTRAAQPGDHILVTGVFLPSVRGASFSGSGRTNQASVSLNTVSGGLLTDTYLEAHSVQLLSK--TDDVTDANEPSEEEIERLRDLEFYSLMAQSLAPEIYGHEDVKKALLLLLVGGVELAPKEGLRIRGNLNICLMGDPGVAKSQLLGFVDRLSPRSQYTTGRGSSGVGLTASVMKDPLTGEMTLEGGALVLADQGVCCIDEFDKMTEFDRTAIHEVMEQQTISIAKAGILTTLNARVAILAAANPAYGRYNPDKSVEQNVDLPAALLSRFDLLWLIQDKPDREHDLRLAQHITFVHMHGSAPSATDSQIDSTSSTNHQQL--LSLPELRRLIAVAKAQPAPAVPAHLADYLVGAYVEMRKEARA-NKEMTYTSARTLLAIMRLSTARARLRAASEVSKGDIDEAMRLMEASRASIITSYEDSNRSGRPQSYKDVIYHIIRELTAAGDGTARIADIAERCATKGYTPAQLNEVIEAYEDLNVWQVNIGRTRITTV 770          

Query:   13 MKMVFMRNYESDKDKFKNFIENFYE--ETSDSKKFIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRAT-VNKTAFDIFIDHCLQIEQNLRDSANGIG--------QPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCK---IGTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLL--------------NTGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKLKDPEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXXXXT-KIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPS----VLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKS---DRARQRTRLGYKELIYQAIRGL-AADSSTVRMADISKKCVSMGFTPDQINEVIDSYEELNIWQVNVGRTRIVLV 2229
            M +  +RNY+ DK     F+  FY   ++  +K F+Y EQ+  I+ +EQ  +Y+S+DD+ E  S+LA  IE N  RY K+    ID+++        V +   DIFIDH +++EQ +R +             +P+ + ++R++FP ELLRR+E YF  R  +K L +RNVL+  +G +I+++ VV RAT VKPL+  ATYTCDRCG+ET+QEI N T +PL  C    CK    G  GRLH+QT+GSK++K QEIRIQE+SDQVP+G+IPR++ ++  G NTR  QPGDH+ +TGVFLP +              +  + T++ GL+T+ +L+AH +  ++K  +DD+ +    +E E+E+L+D E YSLMA+S+APEI+GHEDVKK LL+++ GG  +      +IRG+LNICLMGDPGVAKSQLLGFVDRL PRSQYT GRGSSG GLTASV++D LTGEMTLE G+LVLAD G+CCIDEFDKMT+ DRTAIHEVMEQQTISIAKAGI+TTLNAR +ILAAANPAYGRYNP +++EQN+DLPAALLSRFDLLWLIQDKPDR+ DLRLAQHI++VH +  AP +    + +T++ +   L  LS+ ELRR +A+ ++QP PAVP  L +YLVG Y+ MRKE++A +KE  +TSAR+LLA++R+STA +R++  +EV + D+DEA+RL+EAS+AS+ +   D  R      YK++IY  +R L AA   T R+ADI+++C + G+TP Q+NEVI++YE+LN+WQVN+GRTRI  V
Sbjct:    1 MALSTVRNYDEDKKACDQFLR-FYSKMDSYGNKHFVYSEQLTRIANREQSVLYVSIDDVAEHSSDLANAIECNAVRYTKIFAEVIDDLLPDFRTVELVPQDVLDIFIDHRIRMEQRIRAADAETAPRAVSRDPEPVNMAEVRSRFPPELLRRFEVYFCGRSDAKPLCVRNVLASSIGHLIQVRGVVTRATEVKPLITTATYTCDRCGAETYQEINNPTFMPLTVCGTAACKNAGPGGGGRLHMQTRGSKFLKFQEIRIQELSDQVPVGHIPRALTIYLRGENTRAAQPGDHILVTGVFLPSVRGASFSGSGRTNQASVSLNTVSGGLLTDTYLEAHSVQLLSK--TDDVTDANEPSEEEIERLRDLEFYSLMAQSLAPEIYGHEDVKKALLLLLVGGVELAPKEGLRIRGNLNICLMGDPGVAKSQLLGFVDRLSPRSQYTTGRGSSGVGLTASVMKDPLTGEMTLEGGALVLADQGVCCIDEFDKMTEFDRTAIHEVMEQQTISIAKAGILTTLNARVAILAAANPAYGRYNPDKSVEQNVDLPAALLSRFDLLWLIQDKPDREHDLRLAQHITFVHMHGSAPSATDSQIDSTSSTNHQQL--LSLPELRRLIAVAKAQPAPAVPAHLADYLVGAYVEMRKEARA-NKEMTYTSARTLLAIMRLSTARARLRAASEVSKGDIDEAMRLMEASRASIITSYEDSNRSGRPQSYKDVIYHIVRELTAAGDGTARIADIAERCATKGYTPAQLNEVIEAYEDLNVWQVNIGRTRITTV 770          

Query:   13 MKMVFMRNYESDKDKFKNFIENFYEETSDSKK-FIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEII--HGMGRATVNKTAFDIFIDHCLQIEQNLR---------DSANGIGQPLT--IEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKI---GTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLN--------TGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKLKDPEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXXXXT-KIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAA-GDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKSDRARQRTR---LGYKELIYQAIRG-LAADSSTVRMADISKKCVSMGFTPDQINEVIDSYEELNIWQVNVGRTRIVLV 2229
            M  V  R+YESD+ +   F++ F+    D +K F Y EQ+  ++ + +  I I+LDD+ + + EL   +E N  R+QKL   AID++I  +  G A ++    DIFIDH +++EQ +                 QP    + ++R KFP ELLRRYE YF AR T K +S+R VL+  +G +I+++ VV R T VKPL+++ATYTCDRCG+ET+QEI + + +PL+ C    CK    G+AG+L LQT+GSK+ K QEIRIQE+SDQVP+GNIPR + V+  G NTRLVQPGDHV ITGVFLP           + M      L+ + FLDAH I +++K ES+ L E    +EAE+E+L+DP+MYSLMA+S+APEI+GHEDVKK LL+++ GG  I      +IRG++NICLMGDPGVAKSQLLGFV RL PRSQYT GRGSSG GLTA+V +D  TGEMTLE G+LVLAD G+CCIDEFDKM D DRTAIHEVMEQQTISIAKAGI+TTLNAR ++LAAANPAYGRYNP R++EQNIDLPAALLSRFDLLWLIQD+PDR+ D+RLAQHI+YVH++  AP +   + A G ++G L LS+ ELRR +AI R+QP+P VP  L +YLVG Y+ MRKE++  ++E  +TSAR+LLA++R+STA +R++  +EV + D+DEA+RL+EAS+ASV +     R R   + Y++ IY  IR  L +   + R+ D+ ++C + GFTPDQ+NEVID+YE LN+WQVN+ RTRI  V
Sbjct:    1 MAPVHFRDYESDRVEIIRFLKEFHRSEKDGEKYFPYLEQLSKLANRNENVIRIALDDLWDMNEELTTAVELNTNRFQKLFSEAIDDLIPEYREGEAQIHDV-LDIFIDHRIRMEQRMHTEDIGSEPTPQGQAAEQPNASDMREIRAKFPPELLRRYEVYFTARSTFKPMSVRKVLASSIGHLIQVRGVVSRTTEVKPLLRVATYTCDRCGAETYQEITSPSFMPLILCQTPACKAAGAGSAGQLQLQTRGSKFEKFQEIRIQELSDQVPVGNIPRGLTVYARGENTRLVQPGDHVLITGVFLPSARGTVASRAASAMGGSTGALLADTFLDAHSIIQLSKSESN-LDEE--PSEAEIERLQDPDMYSLMAQSVAPEIYGHEDVKKALLLLLVGGVEIRPQAGLRIRGNINICLMGDPGVAKSQLLGFVYRLSPRSQYTTGRGSSGVGLTAAVTKDPFTGEMTLEGGALVLADQGVCCIDEFDKMADFDRTAIHEVMEQQTISIAKAGILTTLNARVALLAAANPAYGRYNPHRSVEQNIDLPAALLSRFDLLWLIQDRPDRENDMRLAQHIAYVHSHGSAPANAAASGAQGHASGRL-LSLPELRRLIAIARAQPEPVVPAYLADYLVGAYVEMRKEARV-NREMTYTSARTLLAILRLSTARARLRAASEVTKADIDEAMRLMEASRASVSNPVGGPRDRNRPVSYRDQIYAVIRELLGSGGGSTRLTDVMERCANKGFTPDQVNEVIDAYENLNVWQVNMSRTRITAV 764          

Query:   31 RNYESDKDKFKNFIENFYEETSDSKK-FIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEII-HGMGRATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIG-TAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKLKDPEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLT 1692
            ++Y ++K+K K F++ FY E    KK F Y  Q++ ++ +EQ  + + LDD+ E D EL E + +N  RY  L   A+ E++     R  V K A D++I+H L +E   RD A+       + D R ++P+EL+RR+E YF    TSK   +R+V +  +G ++ ++ +V RAT VKP+M +ATYTCD+CG+ET+Q I + + +PL+ C ++ C    + GRL+LQT+GSK+VK QE+RIQE SDQVP+GNIPRSM ++  G NTRLVQPGDHV ++GVFLPLL +G R   +GL++E +L+AH +  + K E D+LG T   +E EL ++ + + Y  +A SIAPEI+GHEDVKK LL+++ GG      G KIRG++NICLMGDPGVAKSQLL ++DRL PRSQYT GRGSSG GLTA+V+RD +TGEMTLE G+LVLAD G+CCIDEFDKM D+DRTAIHEVMEQQTISIAKAGIMT+LNAR SILAAANPAYGRYNPR+TIEQNI LPAALLSRFDLLWLIQDKPD D DLRLAQHI+YVH +++ PP+  T
Sbjct:    4 KDYLAEKEKCKRFLQEFYSEDDSGKKVFKYGAQLVALAHREQVGLVVDLDDVAEEDPELVESVCENTKRYTVLFADAVHELLPEYREREVVAKDALDVYIEHRLMMETRGRDPAD-------MRDPRNQYPAELMRRFEVYFRPPSTSKPKVVRDVKADSIGKLVTVRGIVTRATEVKPMMAVATYTCDQCGAETYQPIASPSFMPLIMCPSQECVTNRSGGRLYLQTRGSKFVKFQELRIQEHSDQVPVGNIPRSMTIYARGENTRLVQPGDHVAVSGVFLPLLRSGFRQAVQGLLSETYLEAHCVTLMNKTEDDELG-TEDLSEEELRQITEEDFYEKLAGSIAPEIYGHEDVKKALLLLLVGGVEQAPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVMRDPVTGEMTLEGGALVLADLGVCCIDEFDKMADADRTAIHEVMEQQTISIAKAGIMTSLNARCSILAAANPAYGRYNPRKTIEQNIQLPAALLSRFDLLWLIQDKPDTDNDLRLAQHITYVHQHSKQPPTHFT 552          

Query:   49 KDKFKNFIENFYEETS--------DSKKFIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIGTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPL-LNTGMRTLNRGLVTELFLDA-HFINRITKDES----DDLGETIPATEAELEKLKD----PEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXXXXT---KIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTS-ARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLL-EASKASVKSDR 2016
            K+KF+ F++ F +  S        D  + +Y +++  IS      + ++   I  FD++L          Y++LI Y   E+I      +VN+  FD F D  L+ +  +R                          Y A        K  ++R++  +++  +I +  +VIR + + P M+ A + C  C   T  E+    +     C +  C   T   L L    S +   Q I++QE  + +P G  P +  V+        VQPGD V ITG++    +    R      V +  +DA HF  R T +      D+  E    TE  +  LK+    P++Y  ++ ++AP I+ HED+KKG+L+ + GG   D + T     R  +NI L GDPG +KSQLL +V  L PR QYT+G+GSS  GLTA V++D  T ++ L+ G+LVL+D GICCIDEFDKM+DS R+ +HEVMEQQT+SIAKAGI+  LNAR SILAAANP   ++NP++T  +NI LP  LLSRFDL++L+ D  D   D RLA H+  ++  +E    ++            L MA L+ Y+A  R+  +P + E     L+  Y+ MR   K GS   + ++  R L +LIR++ A ++++   +V+ IDV+EA RL  EA K S    R
Sbjct:  115 KEKFQRFLQRFIDPESREDENASLDLNEPLYLQKLDEISVVGDPVLNVNCSHIQAFDADL----------YRQLISYP-QEVIPTFD-MSVNELFFDRFPDSVLEHQIQVRP-------------------------YNAL-------KTRNMRSLNPEDIDQLITISGMVIRTSQLIPEMQEAFFRCQVCAFSTRVEVDRGRIAEPAVCRH--C--NTTHSLALVHNRSVFSDKQMIKLQESPEDMPAGQTPHTTVVYAHNDLVDKVQPGDRVNITGIYRAAPMRVNPRQSQVKSVYKTHIDAIHF--RKTDERRLHSLDEENEQKLFTEERVATLKELAAKPDVYERLSSALAPSIYEHEDIKKGILLQLFGGTRKDFSQTGRGNFRAEVNILLCGDPGTSKSQLLQYVFNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMSDSTRSVLHEVMEQQTLSIAKAGIICQLNARTSILAAANPVESQWNPKKTTIENIQLPHTLLSRFDLIFLMLDPQDEAYDRRLAHHLVALYYQSEE--QIVEEY---------LDMAVLKDYIAYARTYINPRLSEEASQALIEAYVDMR---KIGSGRGMVSAYPRQLESLIRLAEAHAKVRFSDKVETIDVEEAKRLHREALKQSATDPR 729          

Query:   58 FKNFIENFYEETSDSKKFIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQ-EILNKTLLPLLTCTNEVCKIGTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITG--VFLPLL-----------------------NTGMRTLNRGLVTEL-----FLDAH-------FINRITKDESDDLGETIP--ATEAELEKL----KDPEMYSLMARSIAPEIFGHEDVKKG-LLXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIF-TSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEAS 1992
            F+ F+E F+    + K     E+++   + E+  + +S  D+  F+ ELA  I++  +R    +C A+       G    +K  +                        + I+DL T+                       IR + +  +GS++++   V+R   V P +   T+ C  C S     E   K   P + C N VC      R  L T  SK++  Q++RIQE   ++P G+IPRSM +          Q GD     G  + +P +                       N G+R L    V EL     FL +H       F  +  +DE +   E+I    T  E EK+    +D  +Y  +  S+ P I G+++VK+G LL++  G       GT +RG +N+C++GDP  AKSQ L  V+   PR+ YT+G+ SS AGLTA+VVRD+ + E  +EAG+L+LAD G+CCIDEFDKM   D+ AIHE MEQQTISI KAG+  TLNAR SILAAANP  GRY+  ++++QN++L A ++SRFDL +++ D  +   D  +A+ I  +H+  E     + T            + E+RRYL   R Q  P + +   +++V  Y  +R+   +G  +S +  + R L ++IR+S +++R+ C  EV    V EA RLL  S
Sbjct:   27 FQAFLEEFHNSDGELKYLRDAEELI---RPERNTLLVSFTDVEGFNQELATTIQEEFYRIYPYLCRAVRNFARDRGNVPASKEFY------------------------VAIQDLPTRH---------------------KIRELTTLRIGSLVRISGQVVRTHPVHPELVSGTFLCLDCQSAIKDVEQQFKYTQPSI-CRNPVC--NNRRRFLLDTNKSKFIDFQKVRIQETQAELPRGSIPRSMEIILRAEAVESAQAGDKCDFIGCLIVVPDVSQLATSGVRAETSSRTAGTQGYENEGVRGLKALGVRELTYKLAFLASHVAPTNPRFGGKEIRDE-EQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGILLMLFGGVPKTTMEGTSLRGDINVCIVGDPSTAKSQFLKHVEEFSPRAVYTSGKASSAAGLTAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMETRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVGGRYDRSKSLKQNVNLTAPIMSRFDLFFILVDDSNEVTDYAIARRIVDLHSRIENSIDRMYT------------LDEIRRYLLFAR-QFKPKISKESEDFIVEQYKRLRQRDGSGVTKSAWRITVRQLESMIRLSESMARMHCCDEVQPKHVKEAFRLLNKS 652          

Query:   58 FKNFIENFYEETSDSKKFIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGS---ETFQEILNKTLLPLLTCTNEVCKIGTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNT----------------------------GMRTLN-RGLVTELFLDAHFIN----RITKDE---SDDLGETIP--ATEAELEKL----KDPEMYSLMARSIAPEIFGHEDVKKG-LLXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIF-TSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKS 2010
            F  F+E F ++  D    +Y  +   + + E+  + +S  +I  ++ +LA  I++  +R    +C A+       G    +K  +  F D                            FPS                    IR + +  +G+++++   V+R   V P +   T+ C  C S   +  Q+   K   P + C N VC      R  L T  S++V  Q++RIQE   ++P G+IPRS+ V          Q GD    TG  + + +                             G++ L  R L   L   A+++     R    E    D   E++    T  E EK+    +D  +Y  +  S+ P I G++++K+G LL++  G A     GT +RG +N+C++GDP  +KSQ L  V+   PR+ YT+G+ SS AGLTA+VV+D+ + E  +EAG+L+LAD G+CCIDEFDKM   D+ AIHE MEQQTISI KAG+  TLNAR SILAAANP  GRYN  ++++QN+++ A ++SRFDL +++ D+ +   D  +A+ I  +H  N    SV    A +          +++RY+   R Q  P +      ++V  Y  +R+    G+ +S +  + R L +++R+S  ++R+ C  EV    V EA RLL  S   V S
Sbjct:   25 FLEFLEEFQDKVGDP---LYLPEAQELIRPERNTLTVSFTNIEHYNQQLATTIQEEYYRVYPFLCRAVRHFARDHGNIPPSKEFYVAFSD----------------------------FPSRQ-----------------KIRELSTARIGTLLRISGQVVRTHPVHPELVSGTFLCLDCQSVIKDVEQQF--KYTQPTI-CKNPVC--ANRRRFMLDTNKSRFVDFQKVRIQETQAELPRGSIPRSVEVVLRAEAVETAQAGDRCDFTGTLIVVPDVSAMALSGTRAETSSRVTGKEGFEADGIQGLKALGVRELSYRLAFLANYVAPTNPRFGGKELRQEDQTAESVKNQMTVQEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEIKRGILLMLFGGVAKTTMEGTSLRGDINVCIIGDPSTSKSQFLKHVEDFVPRAVYTSGKASSAAGLTAAVVKDEESHEFVIEAGALMLADNGVCCIDEFDKMDLKDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPIDGRYNRSKSLKQNVNMSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHARN--IDSVERVYASE----------DIQRYILFAR-QFQPKITPEAQEFVVEQYKRLRQRDGGGTTKSAWRITVRQLESMLRLSEGMARLYCSDEVQPKHVKEAFRLLNKSIIRVDS 656          

Query:   49 KDKFKNFIENFYEETSDSK-KFIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRC-GSETFQEILNKTLLPLLT--CTNEVCKIGTAGRLHLQTKGSKY---------VKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDD-------LGETIPATEAELEKLK-DPEMYSLMARSIAPEIFGHEDVKKGL--LXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKE-----SIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEAS 1992
            K +F+ F+  F   T  +   + YR+++       +  + + ++D+  FD +L++ + K       L+  A  E+   + R                            +G+  T++D++    S+              +   SIR++ S+++  ++K+  ++I ++ V+     AT  C +C G      I N  L P L        C    AGR+        Y         V  Q +R+QE  D VP G +PR M ++C       V PG+ V I G++        +T  R     + + + ++ R+   + D         G   P  E EL  L   P +Y  +ARS+AP I+G +D+KK +  L+       +    T+ RG +N+ ++GDPG AKSQLL FV+R  P   YT+G+GSS AGLTASV+RD  T    +E G++VLADGG+ CIDEFDKM + DR AIHE MEQQTISIAKAGI TTLN+R S+LAAAN  +GR++  +  E NID    +LSRFD++++I+D+ D   D+ LA+H+  VH + +       T      G +PL  A L++Y+A  R +  P +       L   Y+ MR  ++   +E     SI  + R L A++RI+ +L+++K Q      +VDEA+RL + S
Sbjct:   34 KKRFREFLRQFRVGTDRTGFTYKYRDELKRHYTLGEYWVEVEMEDLASFDEDLSDCLYKLPTENLPLLEEAAQEVADEVTRP-------------------------RPVGEE-TVQDIQVMLKSD--------------AHPASIRSLKSEQVSRLVKIPGIIISSSAVRAK---ATRVCLQCRGCRAV--ISNIPLPPGLQGYALPRKCNTEQAGRVKCPV--DPYFIIPDRCVCVDFQTLRLQESPDAVPHGEMPRHMQLYCDRYLCDRVVPGNRVTIMGIYSIKKMATSKTKGRDKGAGVGIRSAYL-RVVGIQVDTEGAGRGATGSVSPLEEEELRALAASPAVYDSIARSLAPSIYGSDDLKKAIACLLFGGSRKRLPDGLTR-RGDINLLMLGDPGTAKSQLLKFVERCSPIGVYTSGKGSSAAGLTASVLRDPNTRGFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDDTKG-EDNIDFMPTILSRFDMIFIIKDQHDHQRDMTLARHVMNVHLSAQ-------TQTEGVEGEIPL--ATLKKYIAYARVKCGPRLSAAAAEKLKNRYVVMRSGAREHERESDRRASIPITVRQLEAVVRIAESLAKMKLQAIAGEEEVDEALRLFQVS 650          

Query:   31 RNYESDKDKFKNFIENFYEETSDSKK-FIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRA-TVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIG-TAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKLKDPEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKSDRARQRTRLGYKELIYQAIRGLAADSST---VRMADISKKCVSMGFTPDQINEVIDSYEELNIWQVNVGRTRIVLV 2229
            ++Y ++KD  K F++ FY++    KK F Y EQ+++++++EQ ++ I LDD+ E + ELAE + +N  RY  L   A+ E++    +   V K A D++I+H L + QN    A+         D + ++P EL+RR+E YF A  T K LS+R+V +  +G ++ ++ VV RAT VKP+M +ATYTCD+CG+ET+Q I + + +PL  C +  C+   + GRL+LQ++GSK+VK QE++IQE SDQVP+G IPR+M V   G NTRL QPGDH+ ITG+FLP+L  G R + +GL++E FL+AH + ++ K E ++L +    +E+EL ++ + + Y  +A SIAPEI+GHEDVKK LL+++ GG      G KIRG++NICLMGDPGVAKSQLL ++DRL PRSQYT GRGSSG GLTA+V++D LTGEMTLE G+LVLAD G+CCIDEFDKM DSDRT+IHEVMEQQTISIAK       + R  +L       G      +    I LPAALLSRFDLLWLIQDKPDRD D+RLAQHI+YVH +   PPS  T          PL M  +RRY+A+ + +  PAVP+TL +Y+   Y+ MRKE++  SK++ FTSAR+LLA++R+STAL+R++    V++ DV+EA RL+E SK S+ +DR +        ++I+  IR LA    T   VR A+   +CVS GFTP Q++  +D YEELN+W VN  RT I  V
Sbjct:    4 KDYAAEKDNCKKFLQEFYKDDGLGKKQFKYGEQLVHLAQREQVSLCIDLDDLAELEPELAERVVENARRYAALFADAVSELLPEYRQGEPVQKDALDVYIEHRLML-QNRHGDADA-------HDPKNQYPPELMRRFELYFKAPGTLKPLSVRDVKANSIGRLVTVRGVVTRATEVKPMMVVATYTCDQCGAETYQPIASTSFMPLALCPSRDCQTNKSGGRLYLQSRGSKFVKFQELKIQEHSDQVPVGCIPRAMTVCVRGENTRLAQPGDHISITGIFLPVLKQGFRAMQQGLLSETFLEAHRVVKMNKTEDNEL-DVEELSESELRQITEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDRSPRGMKIRGNINICLMGDPGVAKSQLLCYIDRLAPRSQYTTGRGSSGVGLTAAVLQDPLTGEMTLEGGALVLADHGVCCIDEFDKMADSDRTSIHEVMEQQTISIAKVTWGVGASTRTRVLQLVGYGRGGGGSCCSRWLGIKLPAALLSRFDLLWLIQDKPDRDNDIRLAQHITYVHQHCHQPPSQHT----------PLDMKLMRRYIALCQRR-QPAVPDTLADYITAAYVEMRKEARV-SKDTTFTSARTLLAILRLSTALARLRLVDVVEKEDVNEA-RLMEMSKDSLITDRGQPTRTQRPSDVIFSLIRELAPPDGTNRRVRYAEALSRCVSRGFTPAQVHTALDEYEELNVWHVNQARTAITFV 720          

Query:   31 RNYESDKDKFKNFIENFYEETSDSKK-FIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRA-TVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIG-TAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKLKDPEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKA--GIMTTLNARASILAAANPAYGRYNP-RRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKSDRARQRTRLGYKELIYQAIRGLAADSST---VRMADISKKCVSMGFTPDQINEVIDSYEELNIWQVNVGRTRIVLV 2229
            ++Y ++KD  K F++ FY++    KK F Y EQ+++++++EQ ++ I LDD+ E + ELAE + +N  RY  L   A+ E++    +   V K A D++I+H L + QN    A+         D + ++P EL+RR+E YF A  T K LS+R+V +  +G ++ ++ VV RAT VKP+M +ATYTCD+CG+ET+Q I + + +PL  C +  C+   + GRL+LQ++GSK+VK QE++IQE SDQVP+G IPR+M V   G NTRL QPGDH+ ITG+FLP+L  G R + +GL++E FL+AH + ++ K E ++L +    +E+EL ++ + + Y  +A SIAPEI+GHEDVKK LL+++ GG      G KIRG++NICLMGDPGVAKSQLL ++DRL PRSQYT GRGSSG GLTA+V++D LTGEMTLE G+LVLAD G+CCIDEFDKM DSDRT+IHEVMEQQTISIAK   G+  +  A  S       A GR +     +   + LPAALLSRFDLLWLIQDKPDRD D+RLAQHI+YVH +   PPS  T          PL M  +RRY+A+ + +  PAVP+TL +Y+   Y+ MRKE++  SK++ FTSAR+LLA++R+STAL+R++    V++ DV+E +RL+E SK S+ +DR +        ++I+  IR LA    T   VR A+   +CVS GFTP Q++  +D YEELN+W VN  RT I  V
Sbjct:    4 KDYAAEKDNCKKFLQEFYKDDGLGKKQFKYGEQLVHLAQREQVSLCIDLDDLAELEPELAERVVENARRYAALFADAVSELLPEYRQGEPVQKDALDVYIEHRLML-QNRHGDADA-------HDPKNQYPPELMRRFELYFKAPGTLKPLSVRDVKANSIGRLVTVRGVVTRATEVKPMMVVATYTCDQCGAETYQPIASTSFMPLALCPSRDCQTNKSGGRLYLQSRGSKFVKFQELKIQEHSDQVPVGCIPRAMTVCVRGENTRLAQPGDHISITGIFLPVLKQGFRAMQQGLLSETFLEAHRVVKMNKTEDNEL-DVEELSESELRQITEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDRSPRGMKIRGNINICLMGDPGVAKSQLLCYIDRLAPRSQYTTGRGSSGVGLTAAVLQDPLTGEMTLEGGALVLADHGVCCIDEFDKMADSDRTSIHEVMEQQTISIAKVTWGVGASTRALCSDGGGRTVAAGRASRIDDCVWLALMLPAALLSRFDLLWLIQDKPDRDNDIRLAQHITYVHQHCHQPPSQHT----------PLDMKLMRRYIALCQRR-QPAVPDTLADYITAAYVEMRKEARV-SKDTTFTSARTLLAILRLSTALARLRLVDVVEKEDVNE-MRLMEMSKDSLITDRGQPTRTQRPSDVIFSLIRELAPPDGTNRRVRYAEALSRCVSRGFTPAQVHTALDEYEELNVWHVNQARTAITFV 723          

Query:  715 KYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVF-LPLLNTGMRTLNRGLVTELFLDAHF-INRITKDESDDLGETI-----PATEAELEKLK-DPEMYSLMARSIAPEIFGHEDVKKGL--LXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAK-AGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKE-----SIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEAS 1992
            K V  Q +++QE  D VP G +PR M ++C       V PG+ + + G++ +    T M+   R        + +  +  IT D +D  G ++     P  E E+ +L   P +Y  +ARSIAP I+G  D+KK +  L++      +    T+ RG +N+ L+GDPG AKSQLL FV+R  P   YT+G+GSS AGLTASV+RD  T    +E G++VLADGG+ CIDEFDKM + DR AIHE MEQQTIS  +  GI TTLN+R S+LAAAN  +GR++  +  E+NID    +LSRFD++++I+D+ +   D+ LA+H+  VH N +   + +    G+      + ++ L++++A  RS+  P +       L   Y+ MR  ++   ++     SI  + R L A++RIS + ++++ Q       VDEA+RL + S
Sbjct:   28 KCVDYQTLKLQEAPDAVPHGEMPRHMQLYCDRYLCDRVVPGNRITVMGIYSIKKAFTKMQGKGRDRTGAGIRNPYLRVVGITVD-TDGAGRSMGIALHPQEEEEIRQLAASPSVYETIARSIAPSIYGFMDIKKAIASLLIGGSRKRLPDGLTR-RGDINLLLLGDPGTAKSQLLKFVERCSPIGVYTSGKGSSAAGLTASVMRDPATRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISTLRIGGITTTLNSRCSVLAAANSVFGRWDDSKG-EENIDFMPTILSRFDMIFIIKDEHNEKRDMILAKHVMNVHLNAK---TQMQAVEGE------IELSTLKKFIAYCRSKCGPRMSAEACEKLKNRYVLMRSGAREHDRDRDHRNSIPITVRQLEAIVRISESQAKMRLQPFATEAHVDEALRLFQVS 457          

Query:  430 RRYEAYFIARKTS---KALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEV-CKIGTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVF--LPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAE-------LEKLKDPEMYSLMARSIAPEIFGHEDVKKGLL-XXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVH 1659
            +++E++++  + S   + LS R + S+ +G+++ ++ +V + ++V+P +  + + C        ++  + T L     +     K   +  L  +   S Y   Q I +QE+ ++ P G +PRS +V          +PGD V + G F  LP    G  +   G    + +  + + ++ K       E +P    E         K     ++  +++S+AP I GHE +KK +L +++ G   I   G++IRG +N+ L+GDP VAKSQ+L +V    PR+  T GRGSSG GLTA+V  DQ TGE  LEAG++VL D G+ CIDEFDKMTD DRTAIHEVMEQ  ++IAKAGI   LNAR S+LAAANP YGRY+  +T  +NI L  +LLSRFDLL+++ D+ D + D  ++ H+  +H
Sbjct:   30 KQFESFYVGLEGSFGARHLSPRTLTSRFLGNMVCVEGIVTKCSLVRPKVVRSVHYCPATQKSIERKYSDLTSLDAFPSSAAYPTKDEESNPLETEYGLSIYRDHQTISLQEMPEKAPAGQLPRSADVVLDDDLVDRCKPGDRVQVIGTFRCLPGKKAGYTS---GTFRTILI-GNNVKQMNK-------EVVPTFSGEDVNKIKTFSKTHSKNIFDQLSKSLAPSIHGHEYIKKAVLCLLLGGTEKILDNGSRIRGDINVLLIGDPSVAKSQMLRYVLHTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLGDRGVVCIDEFDKMTDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPIYGRYDQYKTPMENIGLQDSLLSRFDLLFIVLDQTDPEYDREISDHVLRMH 442          

Query:  481 IRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEI-LNKTLLPL--LTCTNEVCKIGTAGRLHLQTKGSKYVKLQEIRIQEV--SDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVF-LPLLNTGMRTLNRG-LVTELFLDAHFINRITKDESDDLGE-TIP--ATEAELEKL-------KDPEMYSLMARSIAPEIFGHEDVKKGL---LXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNE----------APPSVLTTAAGDSAGLL------------------PLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKSD 2013
            ++N+ +   G ++ ++  V+R   +KPL     ++C+ CG+E    +   K  LP   + C +E C+  T    + +++ ++ V  Q I++QE+   +Q   G IPR++             PGD + +TG+  +   + G    N+   +  L++ A  ++      SD  GE T P  A +  L++L         P ++ L+  SI P I+GHE VK GL   L       G D     +RG  ++ ++GDPG+ KSQ+L  V  + PR  Y  G  ++ AGLT ++ +D  +G+  LEAG+LVL D G+CCIDEFDKM +  + A+ E MEQQ+IS+AKAG++ +L AR SI+AAANP  G YN  +T+ +N+ + +ALLSRFDL++++ D PD + D  L++H+  +H              A P +  TA+  S  +L                  P+  + LR+Y+   R    P +       L   Y+ +R++   G    I T  R L +LIR++ A +R++ +    + D D+ I +++ S +   SD
Sbjct:  211 LKNLRANCYGRLVAIRGTVVRVGNIKPLCTRLAFSCNACGTEQVLRLPYGKFTLPTKRVKCADEDCRSRTF-MPNRRSQLTETVDWQNIKVQELMHGEQREAGRIPRTVECELTHDLVDSCVPGDVITLTGIVKVASSDEGRNKSNKDKCMFLLYIQAVAVSNTKGQRSDGGGEDTAPGVALDFSLKELYAVQEIQAQPHLFRLLVHSICPTIYGHELVKAGLALALFGGVQRYGTDKNRIPVRGDPHVLIVGDPGLGKSQMLQAVCNIAPRGVYVCGNTTTTAGLTVTLSKDGPSGDYALEAGALVLGDQGLCCIDEFDKMPNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIVAAANPVCGHYNKSKTVSENLKMGSALLSRFDLVFILVDTPDEERDHVLSEHVMAMHAGKRMLAGASVSRAAAPGLKLTASSSSDDVLGGLSLSDRLKARRGEALDPVPHSLLRKYVGYARRYVRPCLSAEAAQTLQDFYLELRRQHHGGDGTPITT--RQLESLIRLTEARARLELRENATKEDADDVIDIMKHSFSDTLSD 765          

Query:  115 YREQVLNISKQEQQAIYISLDDINEFDSE----------LAEVIEKNGFRYQKLICYAIDEIIHGMGRAT----VNKTAFDIFIDH-CLQIEQNLRDSANGI----------GQPLT--------IEDLRTKFPSELLRRYEAYF------IARK------TSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIG-TAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKLKDPEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXX-XXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFT----SARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKSDRARQRTRLGYKELIYQAIRGLAADS--STVRMADISKKCVSMGFTPDQINEVIDSYEELNIWQ-VNVGRT 2214
            Y   +  ++ +E  ++ I LDDI ++ +E          L   I++N   + +L C AID   + M   T          D+ ++   L+ E+ L D  N I            P +        +ED    FP  L RRY  YF       AR+      +SK LS+R +    +G +I ++ ++ R + VKP +++  YTCD+CG E FQE+ ++T  PL  CT+E C    T G+L + T+ SK+   QE +IQE+S QVP+G+IPRS+N+H  G   R + PGD V +TG+FLP   TG + L  GL+TE +L+A F+ R  K +      T    E  +E +   ++Y+ +A+SIAPEI+G+ DVKK LL+++ GG       G KIRG +N+CLMGDPGVAKSQLL  + ++ PR  YT G+GSSG GLTA+V++D +T EM LE G+LVLAD GICCIDEFDKM +SDRTAIHEVMEQQTISI+KAGI TTLNAR SILAAANP YGRYNPR +   NI+LPAALLSRFD+L+L+ D P RD D +LA+H++YVH +N+ P    T          P+  +++R Y+A  +++  P + E + +Y+V  YI +R++SK    +S F+    + R+LL +IR+S AL++++    VD  DV+EA+RL+  SK S+  +  + +        I+  I+ +  ++  +T+   +I K     GFT  Q++  I  Y  LN+W  +N G T
Sbjct:   63 YMAMLQKVANRELNSVIIDLDDILQYQNEKFLQGTQADDLVSAIQQNANHFTELFCRAID---NNMPLPTKEIDYKDDVLDVILNQRRLRNERMLSDRTNEIRSENLMDTTMDPPSSMNDALREVVEDETELFPPNLTRRYFLYFKPLSQNCARRYRKKAISSKPLSVRQIKGDFLGQLITVRGIITRVSDVKPAVEVIAYTCDQCGYEVFQEVNSRTFTPLSECTSEECSQNQTKGQLFMSTRASKFSAFQECKIQELSQQVPVGHIPRSLNIHVNGTLVRSLSPGDIVDVTGIFLPAPYTGFKALKAGLLTETYLEAQFV-RQHKKKFASFSLTSDVEERVMELITSGDVYNRLAKSIAPEIYGNLDVKKALLLLLVGGVDKRVGDGMKIRGDINVCLMGDPGVAKSQLLKAICKISPRGVYTTGKGSSGVGLTAAVMKDPVTDEMILEGGALVLADNGICCIDEFDKMDESDRTAIHEVMEQQTISISKAGINTTLNARTSILAAANPLYGRYNPRLSPLDNINLPAALLSRFDILFLMLDIPSRDDDEKLAEHVTYVHMHNKQPDLDFT----------PVEPSKMREYIAYAKTK-RPVMSEAVNDYVVQAYIRLRQDSKR-EMDSKFSFGQATPRTLLGIIRLSQALAKLRLADMVDIDDVEEALRLVRVSKESLYQETNKSKEDESPTTKIFTIIKKMLQETGKNTLSYENIVKTVRLRGFTMLQLSNCIQEYSYLNVWHLINEGNT 800          

Query:   40 ESDKDKFKNFIENFYEETSDSKKF--IYREQVLNISKQEQQAIYISLDDIN-EFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRATVN-------------KTAFDIFIDHCLQIEQNLRDSA------NGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGS-----ETFQEILNKTLLPLLTCTNEVCKIGTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPL----------------------------LN---TGMRTLN-RGLVTEL-FLDAHFI------------------------------NRITKDESDD---LGETIPATE-AELEKL-KDPEMYSLMARSIAPEIFGHEDVKKG-LLXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAG-SKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKSD 2013
            E  ++ F+ F+E+F  +++D+ +   +YR Q+  +   +   IYI    ++   +  LA  I +  +R+   +   +  ++       +N             +   D   D  +      RDS       NG     T     +  P +  R ++  F    T     IR++ S+++GS++ +   V R + V+P +  A++TCD C +     E   +    T  P  +C N            L    S+++  Q++RIQE ++++P G++PR+++V   G +    +PGD    TGV + +                            LN   TG+R+L  R L  ++ FL  H I                              N + +D   D      ++ + E  EL+++ KD  +Y  + RSIAP +FGHE VKKG LL M+ G       G K+RG +NIC++GDP  +KSQ L +V    PRS YT+G+ SS AGLTA+VVRD+  G+ T+EAG+L+LAD GICCIDEFDKM  SD+ AIHE MEQQTISIAKAGI  TLNAR SILAAANP  GRYN + ++  N+++ A ++SRFDL ++I D  +   D  LA HI  +H               D A   P S  +LRRY+   R+   P + +   +YLV  Y  +RK+   G S+ S   + R L ++IR+S A++R  C  E+    + EA  LL  S   V  D
Sbjct:  109 EKVREAFEQFLEDFSVQSTDTGEVEKVYRAQIEFMKIYDLNTIYIDYQHLSMRENGALAMAISEQYYRFLPFLQKGLRRVVRKYAPELLNTSDSLKRSEGDEGQADEDEQQDDDMNGSSLPRDSGSSAAPGNGTSAMATRSITTSTSPEQTERVFQISFFNLPT--VHRIRDIRSEKIGSLLSISGTVTRTSEVRPELYKASFTCDMCRAIVDNVEQSFKYTEPTFCPNPSCENRAF-------WTLNVTRSRFLDWQKVRIQENANEIPTGSMPRTLDVILRGDSVERAKPGDRCKFTGVEIVVPDVTQLGLPGVKPSSTLDTRGISKTTEGLNSGVTGLRSLGVRDLTYKISFLACHVISIGSNIGASSPDANSNNRETELQMAANLQANNVYQDNERDQEVFLNSLSSDEINELKEMVKDEHIYDKLVRSIAPAVFGHEAVKKGILLQMLGGVHKSTVEGIKLRGDINICVVGDPSTSKSQFLKYVVGFAPRSVYTSGKASSAAGLTAAVVRDEEGGDYTIEAGALMLADNGICCIDEFDKMDISDQVAIHEAMEQQTISIAKAGIHATLNARTSILAAANPVGGRYNRKLSLRGNLNMTAPIMSRFDLFFVILDDCNEKIDTELASHIVDLHMKR------------DEAIEPPFSAEQLRRYIKYARTF-KPILTKEARSYLVEKYKELRKDDAQGFSRSSYRITVRQLESMIRLSEAIARANCVDEITPSFIAEAYDLLRQSIIRVDVD 841          

Query:  481 IRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIGTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVF--LPL-LNTGMRTLNRGLVTELFLDAHFINRIT------------------KDESDDLGETIPATEAELEKLKD----PEMYSLMARSIAPEIFGHEDVKKG-LLXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRK---ESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKSD 2013
            +R +   ++  +I LK +V+R+T V P MK+A + C+ C      EI    +     C    C       + L      +   Q I++QE  D VP G  P S+++          + GD + +TG F  +P+  N+  R L    + + ++D   + +++                  K + +++ E    T+ +L K+++     ++YSL+ARSIAP I+  EDVKKG LL +  G       G + RG +NI L GDP  +KSQ+L +V ++ PR  YT+G+GSS  GLTA + RD  T ++ LE+G+LVL+DGG+CCIDEFDKM+DS R+ +HEVMEQQTISIAKAGI+TTLNAR+SILA+ANP   RYNP   + +NIDLP  LLSRFDL++L+ DK D   D  LA+H++ ++   E  P  ++        +LP+    L  Y++  +    P + E     LV  Y+ MRK   +S++  K  I  + R L ++IR++ A +++K +  V+  DV EA+RL+ ++     +D
Sbjct:  314 MRELNPNDIDKLINLKGLVLRSTPVIPDMKVAFFKCNVCDHTMAVEIDRGVIQEPARCERIDC--NEPNSMSLIHNRCSFADKQVIKLQETPDFVPDGQTPHSISLCVYDELVDSCRAGDRIEVTGTFRSIPIRANSRQRVLKS--LYKTYVDVVHVKKVSDKRLDVDTSTIEQELMQNKVDHNEVEEVRQITDQDLAKIREVAAREDLYSLLARSIAPSIYELEDVKKGILLQLFGGTNKTFTKGGRYRGDINILLCGDPSTSKSQILQYVHKITPRGVYTSGKGSSAVGLTAYITRDVDTKQLVLESGALVLSDGGVCCIDEFDKMSDSTRSVLHEVMEQQTISIAKAGIITTLNARSSILASANPIGSRYNPNLPVTENIDLPPPLLSRFDLVYLVLDKVDEKNDRELAKHLTNLYL--EDKPEHIS-----QDDVLPVEF--LTMYISYAKEHIHPIITEAAKTELVRAYVGMRKMGDDSRSDEKR-ITATTRQLESMIRLAEAHAKMKLKNVVELEDVQEAVRLIRSAIKDYATD 839          

Query:   58 FKNFIENFYEETSDSKKFIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAY-FIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSET------FQEILNKTL-LP---LLTCTNEVCKIGTAGRLHLQTK-------------GSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTG-----MRTLNRGLVTELFLDAHFINRITKDESDDLGETIPAT---------EAELEKLKDPEMYSLMARSIAPEIFGHEDVKKGLL-XXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRK-----ESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKS 2010
            FKNFI  F  ++    +FIYR+Q+ N    +  ++ ++++ +  ++ ++          Y+KL     D  I  +    + + A  I       I    + + N    P   E+      S LL     +  I    +  + +R++ S+ +  +++L  ++I  +++       +  C  C   T      F  I   T+ LP   L T  +E      +      TK              SK++  Q +++QE+ + VP+G +PR++ + C    T  V PG  V I G++  + N+       R+      + + +   +I +I   +SD    +I  +         E  L+  ++P++Y ++  SIAP IFG+ED+KK ++ ++M G   I   G ++RG +N+ L+GDPG AKSQLL FV+++ P + YT+G+GSS AGLTASV RD +T E  LE G++VLADGG+ CIDEFDKM D DR AIHE MEQQTISIAKAGI T LN+R S+LAAANP YGRY+  ++   NID    +LSRFD++++++D  + + D+ +A H+  +HT N           G       +S+ +++RY+   R +  P +       L   ++++RK     E ++  + SI  + R L A+IRI+ +L++++         VDEAIRL +AS     S
Sbjct:   31 FKNFILEFRLDS----QFIYRDQLRNNILVKNYSLTVNMEHLIGYNEDI----------YKKLSDEPSD--IIPLFETAITQVAKRI------SILSRAQSANNNDKDP---ENTSMDTDSLLLNSLPTFQLILNSNANQIPLRDLDSEHVSKIVRLSGIIISTSVLSSRATYLSIMCRNCRHTTSITINNFNSITGNTVSLPRSCLSTIESESSMANESNIGDESTKKNCGPDPYIIIHESSKFIDQQFLKLQEIPELVPVGEMPRNLTMTCDRYLTNKVIPGTRVTIVGIY-SIYNSKNGAGSGRSGGGNGGSGVAIRTPYI-KILGIQSDVETSSIWNSVTMFTEEEEEEFLQLSRNPKLYEILTNSIAPSIFGNEDIKKAIVCLLMGGSKKILPDGMRLRGDINVLLLGDPGTAKSQLLKFVEKVSPIAVYTSGKGSSAAGLTASVQRDPMTREFYLEGGAMVLADGGVVCIDEFDKMRDEDRVAIHEAMEQQTISIAKAGITTVLNSRTSVLAAANPIYGRYDDLKSPGDNIDFQTTILSRFDMIFIVKDDHNEERDISIANHVINIHTGNANAMQNQQEENGSE-----ISIEKMKRYITYCRLKCAPRLSPQAAEKLSSNFVTIRKQLLINELESTERSSIPITIRQLEAIIRITESLAKLELSPIAQERHVDEAIRLFQASTMDAAS 693          

Query:  478 SIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGS---ETFQEILNKTLLPLLTCTNEVCKIGTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINR---ITKDESDDLGETIPATEAELEKLK----DPEMYSLMARSIAPEIFGHEDVKKGL-LXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLA-----QHISYVHTNNEAPPSVLTTAAGDSA---------------------------GLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRL-----LEASKASVK 2007
            S+R +    + S++++  VV R T V P +K   + C +CGS     FQ+   +  +    CTN  CK  + G   +  + + Y   Q + +QE    VP G +PR   V  +     + +PG+ V +TG++    +  +   N   V    ++A+ I R    T +E ++  +    TE E  + +    D  +   +  S+AP I+GH D+K  +   +  G          IRG +N+ L+GDPG AKSQ+L +V++   R+ +  G+G+S  GLTASV +D +T E TLE G+LVLAD G+C IDEFDKM D DRT+IHE MEQQ+ISI+KAGI+TTL AR SI+AAANP  GRYN    + QN+ L   +LSRFD+L +++D  D + D RLA      H+     N+E          G+SA                            + P+    L +Y+   R++  P + +  ++ +   Y  +R+ES   S  S   + R L +++RI+ + ++++    V   D+D AI++     ++A K SV+
Sbjct:  305 SLRELRESNLSSLVRVTGVVTRRTGVFPQLKYVKFNCLKCGSILGPFFQDSNEEIRISF--CTN--CK--SKGPFRVNGEKTVYRNYQRVTLQEAPGTVPPGRLPRHREVILLADLVDVSKPGEEVEVTGIYKNNYDGNLNAKNGFPVFATIIEANSIKRREGNTANEGEEGLDVFSWTEEEEREFRKISRDRGIIDKIISSMAPSIYGHRDIKTAVACSLFGGVPKNVNGKHSIRGDINVLLLGDPGTAKSQILKYVEKTAHRAVFATGQGASAVGLTASVRKDPITKEWTLEGGALVLADKGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTTLQARCSIIAAANPNGGRYNSTLPLAQNVSLTEPILSRFDILCVVRDLVDEEADERLATFVVDSHVRSHPENDEDREGEELKNNGESAIEQGEDEINEQLNARQRRLQRQRKKEEEISPIPQELLMKYIHYARTKIYPKLHQMDMDKVSRVYADLRRESI--STGSFPITVRHLESILRIAESFAKMRLSEFVSSYDLDRAIKVVVDSFVDAQKVSVR 854          

Query:   28 MRNYESDKDKFKNFIENFYEETSDSKKFIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMG-RATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIGTAG-RLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKLK-DPEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKSDRARQRTRLGYKELIYQAIRGLAADSSTVRMADISKKCVSMGFTPDQINEVIDSYEELNIWQVNVGRTRIVLV 2229
            M +Y+ + DK K F+  FY +  + K+F Y EQ++ I+ +EQQ + I LDDI E D +LAE +++N  RY++L   AI E++     R    K A DI+I+H L +EQ  R+  N  G  +   D RTK+P ELLRR+E  F    T K  S+RNV +  +G +  ++ +V+R T VKP++++ATYTCD+CG+E++Q I ++T +PLL C +E CK   AG RL+LQT+GSK+VK QE++IQE SDQVP+G+IPRSM +   G NTRL  PGDHV +TG+FLP++ TG R + +GL+++ FL+AH I R+ K E D++  T   ++ E+  L  + + Y  +A S+APEI+GHED+KK LL+++ GG      G KIRG++NI LMGDPGVAKSQ+L ++DRL PRSQYT GRGS+G GLTA+V++D LTGEM LE G+LVLAD G+CCIDEFDKM D DRTAIHEVMEQQT+SIAKAGIMTTLNAR SILAAANPAYGRYNP+++ EQNI LPAALLSRFDLLWLIQDKPD++ DLRLAQHI+YVH ++  PPS             PL M  +RRY+A  + +  P VP  L +Y+V  Y+ MRK+++  + ++ FTSAR+LLA++R++TAL+R++    V++ DV+EA+RL+E SKAS+  D    R  +   + IY  I+ +A D+S+V+M +  ++C+S GFTPDQ  + +  YE L++WQ+N  +TRI  V
Sbjct:    1 MPDYQEELDKAKRFLAEFYVQEDEGKEFKYGEQLIKIAHREQQELLIELDDIAEIDQDLAENVKENTRRYKRLFEDAIYEMLPEYKEREVQTKDALDIYIEHRLLLEQ--RNRQNEPGGAI---DPRTKYPPELLRRFEVNFKHLSTQKHESVRNVKADCIGKLTVVRGIVMRCTEVKPVVEVATYTCDQCGAESYQTIQSQTFMPLLMCPSEECKTNRAGGRLYLQTRGSKFVKFQELKIQEHSDQVPVGHIPRSMTIIAKGENTRLATPGDHVSVTGIFLPMMKTGFRQMTQGLLSDTFLEAHRIVRMNKTEDDEM-PTDDLSDEEIRALSTEADFYDKLASSLAPEIYGHEDIKKALLLLLVGGVDCTPHGMKIRGNINILLMGDPGVAKSQMLSYIDRLAPRSQYTTGRGSTGVGLTAAVMKDPLTGEMILEGGALVLADKGVCCIDEFDKMMDGDRTAIHEVMEQQTVSIAKAGIMTTLNARVSILAAANPAYGRYNPKKSAEQNIQLPAALLSRFDLLWLIQDKPDKENDLRLAQHITYVHQHSAHPPSHYD----------PLDMNLMRRYIAACKEK-QPIVPGELSDYIVSAYVEMRKDAR-NNHDTTFTSARTLLAVLRLATALARLRLADVVEKEDVNEAMRLMEMSKASLSDDEGTVRV-VDPVDAIYGIIKEIAGDASSVKMQEAKQRCLSKGFTPDQFQKCLQEYENLDVWQINQKQTRITFV 718          

Query:   34 NYESDKDKFKNFIENFYEETSDSKKFIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIGTAGR-------LHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVF-----LPLLNTGMRTLNRGL------VTELFLDAHFINRITKDESDDLGETIPATEAELEKLKD-PEMYSLMARSIAPEIFGHEDVKK--GLLXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKE-----SIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEAS 1992
            N  S K +FK F+  F+E T     F YR+Q+       Q  + + L+D++ FD  LA+ + KN   Y  L   A  E+   + R         I  +    ++  LR  AN    P  I +LR                              S+ M +++K+  ++I A+ ++      T  C  C   T   I  K  L       + C     GR         +     K V  Q +++QE  D VP G +PR M ++C    T  V PG+ V + G++         N     +  G+      V  +++D     R T    +      PA E E  +L   P++  ++ARSIAP I+G  D+KK    L+       +    T+ RG +N+ L+GDPG AKSQLL FV+++ P   YT+G+GSS AGLTASV+RD ++    +E G++VLADGG+ CIDEFDKM + DR AIHE MEQQTISIAKAGI TTLN+R ++LAAAN  +GR++  +  +QNID    +LSRFD +++++D+ ++  D+ LA+H+  VH N     +  TT A +      LS++ L++Y++  +S+  P + E+    L   Y+ MR  +K   ++     SI  + R L A+IRIS +L+++          VDEA+RL + S
Sbjct:   27 NRVSAKKRFKEFLREFHEGTF---AFPYRDQLKQHYNLGQYYLEVDLEDLSSFDENLADKLRKNPSEYLPLFETAAKEVADEVTRPR------PIGEEEVQDVQITLRSGAN----PFQIRELR------------------------------SEHMAALVKIPGIIISASSIRSKATNITIQCRSC-QNTISSIPLKPGLEGYAMPRK-CPTDQTGRPPCPLDPFFIMPDKCKCVDFQVLKLQESPDAVPNGEMPRHMQLYCDRYLTERVVPGNRVTVIGIYSIKKVAQKANKERDAIGVGIRKPYLRVVGIYVDTEGPGRSTGAPMN------PADEEEFRRLATRPDVADVIARSIAPSIYGSVDIKKCIACLLFGGSRKRLPDGLTR-RGDINVLLLGDPGTAKSQLLKFVEKVSPIGVYTSGKGSSAAGLTASVMRDPVSRNFVMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCAVLAAANSVFGRWDDTKG-DQNIDFMPTILSRFDTIFIVKDEHNQAKDIHLAKHVMQVHLN-----AAQTTQANEGE----LSLSFLKKYISYCKSKCGPRLSESAAEKLKNRYVLMRSGAKEHERDTEKKISIPITVRQLEAIIRISESLAKMSLSPFATETHVDEALRLFQVS 643          

Query:   52 DKFKNFIENFYEETSDSKKFIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGS---ETFQEILNKTLLPLLTCTNEVCKIGTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLN------------TGMRTLN---------RGL----VTELFLDAHFINRITK-----------DESDDLGETIPA--TEAELEKL----KDPEMYSLMARSIAPEIFGHEDVKKG-LLXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIF-TSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEAS 1992
            D+ +   ++F EE     +  Y      + + E+  + +S  D+  ++++LA +I+++ +R    +C A+       G+   NK  +  FID                                L  R++             IR + S+++GS++++   V+R   V P +  AT+TC  C +   +  Q+   K   P + C N +C+     R  L    S+YV  Q++RIQE   ++P G IPRS+ V          Q GD    TG  + + +            TG R  +         RGL    V +L     F+    +           D  D   E I    T  E +K+    +D  +Y  +  SI P I G+++VK+G LL++  G        T +RG +NIC++GDP  AKSQ L  V+    R+ YT+G+ SS AGLTA+VV+D+ + E  +EAG+++LAD G+CCIDEFDKM   D+ AIHE MEQQTIS+ KAG+  +LNAR S+LAAANP  GRY+  ++++QN+++ A ++SRFDL +++ D+ +   D  +A+ I  +H+  E   SV    A D          E++RYL   R Q  P + +   +Y+V  Y  +R+   + + +S +  + R L ++IR+S A++R+ CQ +V+   V EA RLL  S
Sbjct:   19 DRCQKLFQDFLEEFELDGEVKYLADAQELIRPERNTLVVSYQDVESYNAQLATLIQEDYYRVFPYLCQAVRNFARDRGQVPPNKEFYVSFID--------------------------------LPTRHK-------------IRELTSQKIGSLLRISGQVVRTHPVHPELVTATFTCLDCQTVIKDVEQQF--KYTQPTV-CRNPICQ--NRARFALDINKSRYVDFQKVRIQETQAELPRGCIPRSVEVILRAEAVEQAQAGDKCDFTGTLIVVPDIAQLATPGTRSETGQRQTSGEGYEAEGVRGLKALGVRDLTYRLSFLACSVQATNPRFGGKDLDGDDMTAEAIKKQMTPQEWQKIYEMSRDKNLYQNIINSIFPTIHGNDEVKRGVLLMLFGGVPKKTLEKTSLRGDINICVVGDPSTAKSQFLKHVEEFSARAVYTSGKASSAAGLTAAVVKDEESSEFVIEAGAMMLADNGVCCIDEFDKMDPRDQVAIHEAMEQQTISLTKAGVKASLNARTSVLAAANPIGGRYDRTKSLKQNLNMSAPIMSRFDLFFILVDECNEVVDYAIARRIVDLHSRREQ--SVERVYAVD----------EVQRYLTFAR-QFKPTITKEAQDYMVEQYKHLRERDGSSTTKSAWRITVRQLESMIRLSEAMARLYCQDKVEPKHVKEAYRLLNKS 649          

Query:  481 IRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIGTA------GRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKL----KDPEMYSLMARSIAPEIFGHEDVKKGL-LXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRR----------YLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLL 1983
            +R++    +  +I+   VV  +T + P + +  Y C +C            L P    +++  K G+       G   +  + + Y   Q+I+IQE   +V  G +PR  +V  +       +PGD + +TG++    ++ +   N   V    ++A+FI +      DD       T+ +++ +    KD  +   +  SI P I+GHED+K+ L L +  G A       KIRG +N+ L GDPG AKSQ L +V++  PR+ +T G+G+S  GLTA V R  +T E TLEAG+LVLAD G+C IDEFDKM D+DRT+IHE MEQQ+ISI+KAGI+T+L AR SILAAANP  GRY+P  T  +N+DL   +LSRFD+L +++D  D   D  LA+ +   H  +   P+       D    + + M  LRR          Y+   R +  P +     + +   +  +RKES A    SI  + R + ++IR++ + +++  +  V   DV+ AIR++
Sbjct:  218 LRSLRQLHVNQLIRTGGVVTSSTGIMPQLSVIKYDCPKCSF---------ILGPFFQGSDQEVKPGSCPECQSRGPFEINMEQTLYQNYQKIKIQESPSKVAAGRLPRYKDVILMADLVDSCKPGDEIELTGIYKINYDSSLNRSNGFPVFATIIEANFITK-----QDDKMAVTSLTDEDIKAINALSKDERIGERIIASIGPSIYGHEDIKRALALSLFGGVAKDPGGKHKIRGDINVLLCGDPGTAKSQFLKYVEKTAPRAVFTTGQGASAVGLTAYVQRHPVTKEWTLEAGALVLADKGMCLIDEFDKMNDADRTSIHEAMEQQSISISKAGIVTSLQARCSILAAANPIGGRYDPSLTFAENVDLTEPILSRFDILCVVRDTVDAIQDELLARFVVNSHVRHH--PNTPENEDED----MEVHMFTLRRNAIPQDLLKKYMIYARERVHPRLNNMDQDKVAKMFADLRKESMATG--SIPITVRHIESMIRMAESHAKMHLREYVMEDDVNMAIRVM 717          

Query:  418 SELLRRYEAYFIARKTS---KALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLL-TCTNEVCKIGTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVF--LPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKLKD---PEMYSLMARSIAPEIFGHEDVKKGLL-XXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVH-------TNNEAPP-----SVLTTAAGDSAGLL----------PL-------------SMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFT--SARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLL 1983
            +E  +++E +F+  + S   K ++ R++ S+ +GS++ ++ +V + ++V+P +  + + C +      ++  + T L  + T +    K      L  +     Y   Q   IQE+ ++ P G +PRS+++          +PGD V + G +  LP       +   G  +  F     +N + +  S ++     A++    K       +++ ++A+S+AP I GHE +KK +L +++ G   +   GT++RG +NI L+GDP  AKSQ+L +V    PR+  T GRGSSG GLTA+V  D  TG+  LEAG++VLAD G+ CIDEFDKM+D DRTAIHEVMEQ  ++I+KAGI   LNAR S+LAAANP +GRY+  +    NI +  +LLSRFDLL+++ D+ D D D R+++H+  +H          EA P      VL T   D               P+             SMA +++Y+ + ++   PA+ +   + +   Y  +R +   G+ ++  T  +AR+L  +IR+STA ++ +    +   D   A+ ++
Sbjct:   86 TEYGKKHEEFFVGFEGSFGSKHVTPRSLSSRYIGSMVCVEGIVTKCSLVRPKVVRSVHYCPKTKKTLIRKYTDMTSLEAVPTSSVYPTKDEDGNPLETEYGLCTYKDHQTFTIQEMPERAPAGQLPRSVDIIADNDLVDKCKPGDRVQVIGTYRCLP-------SKRSGFTSGTFRTVLIVNNV-QVMSKEVAPNFSASDISKIKKFSKSKQDVFEVLAKSLAPSIHGHEFIKKAVLCLLLGGTEKVLENGTRLRGDINILLIGDPSTAKSQMLRYVLHSAPRAIPTTGRGSSGVGLTAAVTTDPETGDRRLEAGAMVLADRGVVCIDEFDKMSDIDRTAIHEVMEQGRVTISKAGIHAKLNARCSVLAAANPVFGRYDEFKNPMDNIGMQDSLLSRFDLLFIVLDQMDPDNDRRISEHVLRIHRYRKPGEQEGEALPFGEESDVLATRDPDQEEEDEDTPVYEKHDPMLFGKQKDKKDKFVSMAFMKKYIHVAKAI-KPALTKPAADLISKAYSELRDQENIGNDKAKTTPVTARTLETMIRLSTAHAKARMSKTITEGDAQAAVDMV 645          

Query:   31 RNYESDKDKFKNFIENFYEETSDSKK-FIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMG-RATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIG-TAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKLKDPEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKSDRARQRTRLGYKELIYQAIRGLAAD--------SSTVRMADISKKCVSMGFTPDQINEVIDSYEELNIWQVNVGRTRIVLV 2229
            ++Y ++K+K K F++ FY E  + KK F Y  Q++ ++ +EQ  +++ LDD+ E D EL E I +N  RY  L   A+ E++     R  V K + D++I+H L +EQ L+DSA+         D R ++P EL+RR+E YF    TSK+  +R++ +  +G ++ ++ +V RAT VKP+M +ATYTCD+CG+ET+Q I + + +PL+ C ++ C    + GRL+LQT+GSK+VK QE+RIQE SDQVP+GNIPRSM V+  G NTRL QPGDHV ITGVFLPLL +G     +GL++E +L+AH I  + K E D+L  T   ++ EL  + +   Y  +A SIAPEI+GHEDVKK LL+++ GG      G KIRGS+NICLMGDPGVAKSQLL ++DRL PRSQYT GRGSSG GLTA+V+RD LTGEMTLE G+LVLAD G+CCIDEFDKM D+DRTAIHEVMEQQTISIAKAGIMT+LNAR SILAAANPAYGRYNPR++IE NI LPAALLSRFDLLWLIQDKPD D DLRLAQHI+YVH +   PP+  T          P+ M  +RRY+A+ + +  P VPE L +Y+   Y+ MRKE++  SK++ FTSAR+LL+++R+STAL+R++    V++ DV+EA+RL+E SK S+++D++         ++I+  +R LA +           VRMA+  ++CVS GFTP Q  E ++ YEELN+WQ+N  R+RI  V
Sbjct:    4 KDYAAEKEKCKRFLQEFYTEDGNGKKVFKYGAQLVALAHREQVGLFVELDDVAEEDPELVESISENAKRYTGLFADAVHELLPEYKERDVVAKDSLDVYIEHRLMMEQRLQDSAD-------TRDSRNQYPPELMRRFELYFKPASTSKSKVVRDIRADSIGQLVTVRGIVTRATEVKPMMAVATYTCDQCGAETYQPIQSPSFMPLIMCPSQECVTNKSGGRLYLQTRGSKFVKFQELRIQEHSDQVPVGNIPRSMTVYARGENTRLAQPGDHVAITGVFLPLLRSGYSQAIQGLLSETYLEAHNITLMNKTEDDELA-TEELSDEELRSITEEGFYEKLAGSIAPEIYGHEDVKKALLLLLVGGVEQAPKGMKIRGSINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVMRDPLTGEMTLEGGALVLADLGVCCIDEFDKMADADRTAIHEVMEQQTISIAKAGIMTSLNARCSILAAANPAYGRYNPRKSIEANIQLPAALLSRFDLLWLIQDKPDADADLRLAQHITYVHQHCRQPPTHFT----------PIDMKLMRRYIALCKKR-QPVVPEALADYITAAYVEMRKEARV-SKDTTFTSARTLLSILRLSTALARLRMMDTVEKEDVNEAMRLMEMSKDSLQADKSSATRAHRPADVIFSLVRELATESAAGRGGSGGVVRMAEAEQRCVSRGFTPAQFQEALEEYEELNVWQINQARSRITFV 727          

Query:   49 KDKFKNFIENFYEETS--------DSKKFIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIGTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPL-LNTGMRTLNRGLVTELFLDA-HFINRITKDES----DDLGETIPATEAELEKLKD----PEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXXXXT---KIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTS-ARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLL-EASKASVKSDR 2016
            K+KF+ F++ F + TS        D  + +Y +++  IS      + ++   +  FD+EL          Y++LICY   E+I     A VN+  F+ F D  L+ +  +R              L+TK                      ++RN+  +++  +I L  +VIR + + P M+ A + C  C      E+    +     C N  C       + L    S +   Q I+IQE  + +P G  P +  ++        VQPGD V ITG++  + +    R  N   V +  +DA HF  R T ++     D  GE    TE  ++ LK+    P++Y  +A ++AP I+ HED+KKG+L+ + GG   D + T     R  +NI L GDPG +KSQLL +V  L PR QYT+G+GSS  GLTA V++D  T ++ L+ G+LVL+D GICCIDEFDKM+D+ R+ +HEVMEQQT+SIAKAGI+  LNAR ++LAAANP   ++NP++T  +NI LP  LLSRFDL++L+ D  D   D RLA H+  ++  +E           +      L MA L+ Y+A  R+   P + E     L+  Y+ MR   K GS   + ++  R L +LIR++ A ++++   +V+ IDV+EA RL  EA K S    R
Sbjct:  122 KEKFQRFLQRFIDPTSTEDENAGLDLNEPLYMQKLEEISVVGDPVLNVNCRHVQSFDAEL----------YRQLICYP-QEVIPTFDMA-VNELFFERFPDSVLEYQIQVR----------PYNALKTK----------------------NMRNLNPEDIDQLITLGGMVIRTSQLIPEMQEAFFQCQVCAFSARVEVDRGRIAEPAVCRN--C--NNTHSMTLVHNRSVFSDKQMIKIQESPEDMPAGQTPHTTILYAHNDLVDKVQPGDRVNITGIYRAVPMRVHPRQSNVRSVYKTHIDAIHF--RKTDEKRLHGLDQDGEQKLFTEDRVQTLKELAAKPDVYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSQTGRGNFRAEVNILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMSDNTRSVLHEVMEQQTLSIAKAGIICQLNARTAVLAAANPVESQWNPKKTTIENIQLPHTLLSRFDLIFLMLDPQDEAYDRRLAHHLVSLYYQSE-----------EQMEEEFLDMAVLKDYIAYARTYISPRLSEEASQALIEAYVDMR---KIGSGRGMVSAYPRQLESLIRLAEAHAKVRFSEKVETIDVEEAKRLHREALKQSATDPR 736          

Query:   49 KDKFKNFIENFYEETS--------DSKKFIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIGTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPL-LNTGMRTLNRGLVTELFLDA-HFINRITKDES----DDLGETIPATEAELEKLKD----PEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXXXXT---KIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTS-ARSLLALIRISTALSRIKCQTEVDRIDVDEAIRL-LEASKASVKSDR 2016
            K+KF+ F++ F + TS        D  + +Y +++  IS      + ++   +  FD+EL          Y++LICY   E+I     A VN+  F+ F D  L+ +  +R              L+TK                      ++RN+  +++  +I L  +VIR + + P M+ A + C  C      E+    +     C N  C       + L    S +   Q I+IQE  + +P G  P +  ++        VQPGD V ITG++  + +    R  N   V +  +DA HF  R T ++     D  GE    TE  ++ LK+    P++Y  +A ++AP I+ HED+KKG+L+ + GG   D + T     R  +NI L GDPG +KSQLL +V  L PR QYT+G+GSS  GLTA V++D  T ++ L+ G+LVL+D GICCIDEFDKM+D+ R+ +HEVMEQQT+SIAKAGI+  LNAR ++LAAANP   ++NP++T  +NI LP  LLSRFDL++L+ D  D   D RLA H+  ++  +E           +      L MA L+ Y+A  R+   P + E     L+  Y+ MR   K GS   + ++  R L +LIR++ A ++++   +V+ IDV+EA RL  EA K S    R
Sbjct:  158 KEKFQRFLQRFIDPTSTEDENAGLDLNEPLYMQKLEEISVVGDPVLNVNCRHVQSFDAEL----------YRQLICYP-QEVIPTFDMA-VNELFFERFPDSVLEYQIQVR----------PYNALKTK----------------------NMRNLNPEDIDQLITLGGMVIRTSQLIPEMQEAFFQCQVCAFSARVEVDRGRIAEPAVCRN--C--NNTHSMTLVHNRSVFSDKQMIKIQESPEDMPAGQTPHTTILYAHNDLVDKVQPGDRVNITGIYRAVPMRVHPRQSNVRSVYKTHIDAIHF--RKTDEKRLHGLDQDGEQKLFTEDRVQTLKELAAKPDVYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSQTGRGNFRAEVNILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMSDNTRSVLHEVMEQQTLSIAKAGIICQLNARTAVLAAANPVESQWNPKKTTIENIQLPHTLLSRFDLIFLMLDPQDEAYDRRLAHHLVSLYYQSE-----------EQMEEEFLDMAVLKDYIAYARTYISPRLSEEASQALIEAYVDMR---KIGSGRGMVSAYPRQLESLIRLAEAHAKVRFSEKVETIDVEEAKRLHREALKQSATDPR 772          

Query:   58 FKNFIENFYEETSDSKKFIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIGTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFL----------PLLNT----------------GMRTLNRGLVTEL-----FL-------DAHFINRITKDESDDLGETIPA--TEAELEKL----KDPEMYSLMARSIAPEIFGHEDVKKG-LLXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAG--SKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKS 2010
            F+ F+E F  +T+D +    RE    + + E+  + +S  D+  F+ ELA  I++  +R    +C A+       G   + K  +                        + IEDL T+                       IR + S  +G+++K+   V+R   V P +   T+ C  C              P   C N VC      R HL T  SK++  Q++RIQE   ++P G+IPRS+ V          Q GD    TG  +          P L                  G+R L    V EL     FL       +  F  +  +DE +   E+I +  TE E EK+    +D  +Y  +  S+ P I G+++VK+G LL++  G       GT +RG +N+C++GDP  AKSQ L  V+   PR+ YT+G+ S+ AGLTA+VVRD+ + E  +EAG+L+LAD G+CCIDEFDKM   D+ AIHE MEQQTISI KAG+  TLNAR SILAAANP  GRY+  ++++QN++L A ++SRFDL +++ D  +   D  +A+ I  +H+  E     L             S+ E+RRYL   R Q  P + +    ++V  Y  +R+    G  SK +   + R L ++IR+S A++R+ C  EV    V EA RLL  S   V++
Sbjct:   27 FQAFLEEF--QTADGEVKYLREGE-ELIRPERNTLVVSFTDLEGFNQELATTIQEEYYRVYPYLCRAVRNFARDHGNVPLTKEFY------------------------VAIEDLPTRH---------------------KIRELSSMRIGTLVKISCQVVRTHPVHPELVSGTFVCMDCQMVIKDVPQQFKYSPPTICRNPVC--SNRSRFHLDTHKSKFIDFQKVRIQETQAELPRGSIPRSLEVVLRAEAVETAQAGDRCDFTGTLIVVPDVSQLSTPGLRAETSSRVGGGRQGYEAEGLRGLKALGVRELSYRLAFLACNVAPTNPRFGGKELRDE-EQTAESIKSQMTEKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGILLMLFGGVPKTTMEGTSLRGDVNVCIVGDPSTAKSQFLKHVEEFSPRAVYTSGKASTAAGLTAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDIKDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVGGRYDRSKSLKQNVNLTAPIMSRFDLFFILVDDCNEVTDYAIARRIVDLHSRVEESVDRL------------YSLDEIRRYLLFAR-QFKPKISKESEEFIVEQYKRLRQRDSTGSVSKSAWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLNKSIIRVET 660          

Query:  478 SIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLT--CTNEVCKIGTAGRLHLQTKGSKY---------VKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINRI---TKDESDDLGETIPATEAELEKLK----DPEMYSLMARSIAPEIFGHEDVKKGL--LXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKE-----SIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEAS 1992
            SIRN+ S+++  ++K+  ++I AT VK         C  C S     I N  L P L        C    AGR+  +     Y         V  Q +R+QE  D VP G +PR + ++C       V PG+ V I G++       ++   +     + + + ++  +      E    G T P +  E E+L+     P +YS +A+S+AP I+G +D+KK +  L+       +    T+ RG +N+ ++GDPG AKSQLL FV+R  P   YT+G+GSS AGLTASV+RD  T    +E G++VLADGG+ CIDEFDKM + DR AIHE MEQQTISIAKAGI TTLN+R S+LAAAN  YGR++  +  E NID    +LSRFD++++I+D  D+  D+ LA+H+  VH + +       T      G +PL  A  ++Y+A  R++  P +       L   Y+ MR  ++   +E     SI  + R L A+IRI+ +L+++K Q      +VDEA+RL + S
Sbjct:  152 SIRNLKSEQVSRLVKVHGIIISATAVKAKATKVCLQCRGCRSV----IPNIPLPPGLQGYALPRKCNSENAGRV--KCPMDPYFIIPDRCVCVDFQTLRLQESPDAVPHGEMPRHLQLYCDRYLCDRVVPGNRVTIMGIYSIKKMAAVKAKGKEKGIGVGIRSSYLRVVGIQVDTEGAGRGATGPVSAQEEEELRALSTSPNIYSSLAQSLAPSIYGSDDLKKAITCLLFGGSRKRLPDGLTR-RGDINLLMLGDPGTAKSQLLKFVERCSPIGVYTSGKGSSAAGLTASVLRDPSTRGFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVYGRWDDTKG-EDNIDFMPTILSRFDMIFIIKDHHDQQRDMTLARHVMNVHLSAQ-------TQTEGVEGEIPL--ATFKKYIAYARAKCGPRLSAAAAEKLKNRYVVMRSGAREHERESDKRPSIPITVRQLEAVIRIAESLAKMKLQAVAGEEEVDEALRLFQVS 664          

Query:   19 MVFMRNYESDKDKFKNFIENFYEETSDSKKFIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIGTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKLKDPEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKSDRARQRTRLGYKELIYQAIRGLAADSSTVRMADISKKCVSMGFTPDQINEVIDSYEELNIWQVNVGRTRIVLVN 2232
            MVFMRNYESDKDK KNFIENFYEETSDSKKFIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIGTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKLKDPEMYSLMARSIAPEIFGHEDVKKGLLIMMAGGAGIDAAGTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKSDRARQRTRLGYKELIYQAIRGLAADSSTVRMADISKKCVSMGFTPDQINEVIDSYEELNIWQVNVGRTRIVLVN
Sbjct:    1 MVFMRNYESDKDKLKNFIENFYEETSDSKKFIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIGTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKLKDPEMYSLMARSIAPEIFGHEDVKKGLLIMMAGGAGIDAAGTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKSDRARQRTRLGYKELIYQAIRGLAADSSTVRMADISKKCVSMGFTPDQINEVIDSYEELNIWQVNVGRTRIVLVN 738          

Query:   28 MRNYESDKDKFKNFIENFYEETSDSKKFIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIGTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKLKDPEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKSDRARQRTRLGYKELIYQAIRGLAADSSTVRMADISKKCVSMGFTPDQINEVIDSYEELNIWQVNVGRTRIVLVN 2232
            MRNYESDKDK KNFIENFYEETSDSKKFIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIGTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKLKDPEMYSLMARSIAPEIFGHEDVKKGLLIMMAGGAGIDAAGTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKSDRARQRTRLGYKELIYQAIRGLAADSSTVRMADISKKCVSMGFTPDQINEVIDSYEELNIWQVNVGRTRIVLVN
Sbjct:    1 MRNYESDKDKLKNFIENFYEETSDSKKFIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIGTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDDLGETIPATEAELEKLKDPEMYSLMARSIAPEIFGHEDVKKGLLIMMAGGAGIDAAGTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKASVKSDRARQRTRLGYKELIYQAIRGLAADSSTVRMADISKKCVSMGFTPDQINEVIDSYEELNIWQVNVGRTRIVLVN 735          

Query:   58 FKNFIENFYEETSDSKKFIYREQVLNISKQEQQAIYISLDDINEFDSELAEVIEKNGFRYQKLICYAIDEIIHGMGRATVNKTAFDIFIDHCLQIEQNLRDSANGIGQPLTIEDLRTKFPSELLRRYEAYFIARKTSKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLT-CTNEVCKIGTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITG--VFLP----LLNTGMRTLN----------------------RGLVTELFLDAHFINRITKD--ESDDLGE---------TIPATEAELEKL----KDPEMYSLMARSIAPEIFGHEDVKKGLLXXXXXXX-XXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMR-KESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEAS 1992
            F N +ENF  +  D  +F Y E    ++  E+  + +S  D+  +DS L++ I  N +R    +C A    I+     T N                                           R Y  +FI   T    ++RN+    +G ++K +  VIR+  V P + + T+ C  CG+   + I  + +    T C N  C      +  L  + SKYV  Q++R+QE  +++P G IPR M+V          QPGD    TG  + +P    L   G RTL                       R L   +   A+ +  +     +++D+ E             TE E+ K+    +DP +   M   + P  +G+++VK+GLL+M+ GG   +   GTK+RG +NIC++GDP  AKSQ L  +    PR+ YT+G+ SS AGLTA+VVRDQ +GE  +EAG+L+LA+ G+CCIDEFDKM   D+ AIHE MEQQTIS+ KAGI  TLNA+ S+LAAANP  GRY+  R++ QNI L A ++SRFDL +++ D+     D  +A+ I    T ++ P         + +     +  +++RY+   R   +P V E     +V  Y  MR +++ +GS+ +   + R L +L+R+S A +R++    V+  DV EA RLL  S
Sbjct:   25 FLNLLENF--KVGD--EFKYVENAKKMTSLEKMFLGVSFKDLMTYDSGLSQDIMLNFYRLYPFLCQATQIFINKQFDETENND-----------------------------------------RTYTCHFIDFPT--LTNLRNLRMGNLGKLVKFRGQVIRSHGVHPELVLGTFKCQDCGT-VVKNIEQQFIFTKPTICGNPQCM--NRLKFELIPEQSKYVDFQKVRVQETQNELPRGCIPRCMDVILRNETVENAQPGDQSEFTGSLIIIPDISQLTTPGSRTLETKQIKLSEGYDSGVTGLKELGVRDLTYRMAFLANHVATVNNKYLQTEDMNEEGELTYDSLMKKLTEQEVNKVLTMNQDPNLVKNMCDCLFPTTYGNDEVKRGLLLMLFGGVPKVTEEGTKLRGDINICIVGDPSTAKSQFLKRIAGFSPRAVYTSGKASSAAGLTAAVVRDQESGEFVIEAGALMLANNGVCCIDEFDKMEVRDQVAIHEAMEQQTISLTKAGIKATLNAKTSVLAAANPVGGRYDRSRSLRQNISLSAPIMSRFDLFFVLIDECTEQVDHEIAKRI----TESQRP------VDPEKSDTRIYNEDDIQRYITFARC-FEPRVTEEAFKLMVTEYAKMRERDAASGSRSAWRITVRQLESLVRLSEATARMRFSDFVEECDVVEANRLLSKS 654          

Query:  478 SIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRCGSETFQEILNKTLLPLLTCTNEVCKIGTAGRLHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLL---NTGMRTLNRGLVTELFLDA-HF---INRITKDESDDLG-ETIPATEAELEKLKDPEMYSLMARSIAPEIFGHEDVKKGLLXX----XXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHIS--YVHTNNEAPPSVLTTAAGDSAGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRKESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRL 1980
            ++RN+  +++  ++ +  +VIR + + P M  A + C  C + T        ++    C N+     T   +H      +++  Q +++QE  + +P G  P ++ ++C       +QPGD V +TG++       N+  R +    V + +LD  HF    NR+  +E   L  E +    A  +K   P++Y  ++ +IAP I+G+E +KKGLL+M             AG  +R ++++ L GDPG +KSQLL +V  L PR QYT+G+GSS  GLTA + +D  TG  TL++G+L L+D GICCIDEFDKMTD+ R+ +HEVMEQQ++SIAKAGI+  L+AR S+LAAANP    ++ ++TI +NI LP  LLSRFDL++LI D  D   D +LA+HI   Y   N    P  + TA              LR Y+A  +    P + E   NY+   Y+ MRK   AG K  I    R L +LIR++ A +R++   +V   D  EA RL
Sbjct:  183 NLRNLNPEDLDQLVTVNGLVIRLSEIIPEMIKAHFKCSVCNNVTKVPCERGRIIDPEFC-NQCQAKHTQQIVH---NCCEFIDKQMVKLQESPEDMPAGETPHTVVLYCYQDLVDTIQPGDRVTVTGIYRAASQRENSKQRVIK--AVFKTYLDVLHFQKSKNRLIDEEEAKLSQERVVEIRALSQK---PDLYERLSGAIAPTIYGNETIKKGLLMMLFGGRVKETKKLGAGENMRSNIHVLLCGDPGTSKSQLLQYVYNLTPRGQYTSGKGSSKVGLTAYITKDPETGSSTLQSGALALSDNGICCIDEFDKMTDTTRSVLHEVMEQQSLSIAKAGIICQLHARTSVLAAANPIGSCWDNKKTIIENIQLPPTLLSRFDLIFLILDPQDEQYDAKLARHIVGLYCGHNKTTEPGTVDTAM-------------LRDYIAYAKENIHPILSEEAENYVTEEYVEMRKVGNAG-KGQISAYPRQLESLIRLAEAHARMRLSDQVTVADCLEARRL 674          

Query:  466 SKALSIRNVLSKEMGSVIKLKAVVIRATMVKPLMKIATYTCDRC----GSETFQEILNKTLLP---LLTCTNEVCKIGTAGR------LHLQTKGSKYVKLQEIRIQEVSDQVPIGNIPRSMNVHCVGANTRLVQPGDHVFITGVFLPLLNTGMRTLNRGLVTELFLDAHFINRITKDESDDLGET------IPATEAELEKLKD----PEMYSLMARSIAPEIFGHEDVKKGL-LXXXXXXXXXXXXXTKIRGSLNICLMGDPGVAKSQLLGFVDRLCPRSQYTNGRGSSGAGLTASVVRDQLTGEMTLEAGSLVLADGGICCIDEFDKMTDSDRTAIHEVMEQQTISIAKAGIMTTLNARASILAAANPAYGRYNPRRTIEQNIDLPAALLSRFDLLWLIQDKPDRDGDLRLAQHISYVHTNNEAPPSVLTTAAGDS----AGLLPLSMAELRRYLAIIRSQPDPAVPETLLNYLVGCYISMRK-----ESKAGSKESIFTSARSLLALIRISTALSRIKCQTEVDRIDVDEAIRLLEASKAS 2001
            S   S+R + S ++  +IK+  VV+ A+ +K      T  C  C     S + +  LN  +LP   + + ++    +G   +       +++    K    Q +++QE  + VP G +PR   +           PG+ V + G+   +    M     G+        H   R+   E ++ G T      +  T+ E ++ ++    P ++ ++ARSIAP I+G+ D+KK +  ++  G       G  +RG +N+ ++GDPG AKSQLL FV++  P + YT+G+GSS AGLTASV+RD  T    +E G++VLADGG+ CIDEFDKM + DR AIHE MEQQTISIAKAGI T LN+R S+LAAAN  +G ++  +  ++NID    ++SRFD++++++D  D   D ++ +H+  VH  +     V    + DS     G++P+   +L++Y+A  R Q  P +    L  +   Y+SMR      E + G   SI  + R L A++RI+ +L++++        D  EAIRL + S  S
Sbjct:  124 SHPKSLREIKSNQISKLIKISGVVVSASGIKSKAATLTLRCKGCQQYLPSVSVKPGLNGYVLPRKCIASASSARFGVGQTAQSCPVDPYYIEPDKCKCNDFQILKLQEAPENVPHGEMPRHSQLFVDRYLCEKAVPGNRVTVVGISSIIQQDSMNMPKDGV-------KHSYIRVLNVEIENTGSTRSGISSLGVTDKEEKEFREFSLKPGVHEIIARSIAPGIYGNPDIKKAIACLLFGGSRKKMPEGVFLRGDINMMMLGDPGTAKSQLLKFVEQCAPIAVYTSGKGSSAAGLTASVIRDSATRSFVMEGGAMVLADGGVVCIDEFDKMKEDDRVAIHEAMEQQTISIAKAGITTMLNSRCSVLAAANSVFGHWDETKG-DENIDFMPTIMSRFDMIFVVKDVYDEKRDKQIVEHVMSVHMGDGQAADVNENISLDSLTAETGIMPV--LKLKKYIAFCRDQCGPRLTPEALKIITNHYVSMRSGASEYEKETGKNTSIPITIRQLEAIVRIAESLAKMRLAPFGVEADAREAIRLFQVSTLS 658