RING-type domain-containing protein

Overview
NameRING-type domain-containing protein
Smed IDSMED30030902
Length (bp)2828
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of RING-type domain-containing protein (SMED30030902) t-SNE clustered cells

Violin plots show distribution of expression levels for RING-type domain-containing protein (SMED30030902) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of RING-type domain-containing protein (SMED30030902) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for RING-type domain-containing protein (SMED30030902) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30030902

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 1

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X2 cellSMED30030902SMESG000016211.1 SmedASXL_001215SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Human
Match: ZNF598 (zinc finger protein 598 [Source:HGNC Symbol;Acc:HGNC:28079])

HSP 1 Score: 128.257 bits (321), Expect = 1.689e-29
Identity = 67/252 (26.59%), Postives = 120/252 (47.62%), Query Frame = 3 
Query:   69 CGLTDKEIDFYGFSYCNHPICGVCSIKLQKFSKDVGNDYDYSKCVICKQDISKIILASSIKPFESFDQTNLLCDTQYDLLFESTKAESYYKNVIKIKCPKCK--MPHNSMDDMILHMN-DHKMRYCDLCVTFNKCLHYELEIYSDNDYHQHR---------YKKHPKCKFCETRFYDDSHLIKHVKDKHFVCDICHRNHGCVAYKTQIELLRHYSMDHFVCEICRSSNN--INVFESEYNLKTHKVSVHSSS 782
            C L   +++      C+HP+C  CS K++          +   C +C++++ +++    +  F +     L  + +YD+ F   K  + Y+ +++ +CP+C    P +   D+  HM   H++  C LC+   +   YE + YS  D  +HR         ++ HP CKFC+ R+ D+  L+KH++  H+ C  C  +     Y     L  H+   HF+CE  R S     + F +E +LK H+ + HS S
Sbjct:   29 CVLCCGDLEATALGRCDHPVCYRCSTKMRVLC-------EQRYCAVCREELRQVVFGKKLPAFATIPIHQLQHEKKYDIYFADGKVYALYRQLLQHECPRCPELPPFSLFGDLEQHMRRQHELFCCRLCLQHLQIFTYERKWYSRKDLARHRMQGDPDDTSHRGHPLCKFCDERYLDNDELLKHLRRDHYFCHFCDSDGAQDYYSDYAYLREHFREKHFLCEEGRCSTEQFTHAFRTEIDLKAHRTACHSRS 273
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Human
Match: ZNF598 (zinc finger protein 598 [Source:HGNC Symbol;Acc:HGNC:28079])

HSP 1 Score: 117.087 bits (292), Expect = 4.558e-26
Identity = 58/209 (27.75%), Postives = 103/209 (49.28%), Query Frame = 3 
Query:  198 CVICKQDISKIILASSIKPFESFDQTNLLCDTQYDLLFESTKAESYYKNVIKIKCPKCK--MPHNSMDDMILHMN-DHKMRYCDLCVTFNKCLHYELEIYSDNDYHQHR---------YKKHPKCKFCETRFYDDSHLIKHVKDKHFVCDICHRNHGCVAYKTQIELLRHYSMDHFVCEICRSSNN--INVFESEYNLKTHKVSVHSSS 782
            C +C++++ +++    +  F +     L  + +YD+ F   K  + Y+ +++ +CP+C    P +   D+  HM   H++  C LC+   +   YE + YS  D  +HR         ++ HP CKFC+ R+ D+  L+KH++  H+ C  C  +     Y     L  H+   HF+CE  R S     + F +E +LK H+ + HS S
Sbjct:   10 CAVCREELRQVVFGKKLPAFATIPIHQLQHEKKYDIYFADGKVYALYRQLLQHECPRCPELPPFSLFGDLEQHMRRQHELFCCRLCLQHLQIFTYERKWYSRKDLARHRMQGDPDDTSHRGHPLCKFCDERYLDNDELLKHLRRDHYFCHFCDSDGAQDYYSDYAYLREHFREKHFLCEEGRCSTEQFTHAFRTEIDLKAHRTACHSRS 218
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Celegans
Match: C52E12.1 (pep chromosome:WBcel235:II:7025802:7030152:1 gene:WBGene00016888.1 transcript:C52E12.1.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:C52E12.1)

HSP 1 Score: 98.2117 bits (243), Expect = 1.463e-20
Identity = 68/277 (24.55%), Postives = 119/277 (42.96%), Query Frame = 3 
Query:   54 FDCPVCGLTDKEIDFYGFSYCNHPICGVCSIKLQKFSKDVGNDYDYSKCVICKQDISKIILASSIKPFE----SFDQTNLLCDTQYDLLFESTKAESYYKNVIKIKCPKCK------MPHNSMDDMILHM-NDHKMRYCDLCVTFNKCLHYELEIYSDNDYHQH---------RYKKHPKCKFCETRFYDDSHLIKHVKDKHFVCDICHRNHGC--VAYKTQIELLRHYSMDHFVCEICRSSNNINVFESEYNLKTHKVSVHSSSLVGEGLVTVGFG 818
             DC +C    K+ D +G   C HP+C  C I++    + +GN      C +C+ DI  +   ++         SF +T    + +YD+ F +  A + Y+  +   C  CK      +   S   +  HM + H+  YC +C         E + Y+ +   +H          +K HP+C FCE +F D+ +  +H++  HF C  C  +     V +     L +HY   H++CE          F +++ L  H+ + H+       L+ +GFG
Sbjct:   87 IDCDICC---KKNDVFGIGSCRHPVCAECVIRM----RILGNS---KTCPVCRSDIDILSFCTTDDDLANVPLSFKKTAHPDEDRYDIRFSNKIAGTKYEKYLAHVCKICKTDDGERLEFPSFMSLRQHMASRHEQSYCHICTDNLNLFSRERKTYTRDQLQRHMRSGDFDDKSFKGHPQCLFCEQKFLDEENRYRHLRKDHFFCQFCESDGTMTNVFFGKHDGLKKHYKEHHYICETEECREMGIAFANKFELDLHRANEHAER---RNLIELGFG 350
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Fly
Match: CG11414 (gene:FBgn0035024 transcript:FBtr0072307)

HSP 1 Score: 132.109 bits (331), Expect = 4.000e-31
Identity = 129/571 (22.59%), Postives = 232/571 (40.63%), Query Frame = 3 
Query:   66 VCGLTDKEIDFYGFSYCNHPICGVCSIKLQKFSKDVGNDYDYSKCVICKQDISKIILASSIKPFESFDQTNL--LCDTQYDLLFESTKAESYYKNVIKIKCPKCKMP-HNSMDDMILHM-NDHKMRYCDLCVTFNKCLHYELEIYSDNDYHQHR---------YKKHPKCKFCETRFYDDSHLIKHVKDKHFVCDICHRNHGCVAYKTQIELLRHYSMDHFVCE--ICRSSNNINVFESEYNLKTHKVSVHSSSLVGEGL-------VTVGFG----DNRDNQRYGNRRRQRDEDAFFVDSLPTAMEIPQVLPTFNCEQEFPRLGADAVASSQQLGVPSLTLDRNDARAAFIDQTETVMSEKETNKIQMTTAATSQANVGSSSNRHEKMSDNIAIMVKRSAGSLNSEDFPSLSSSLATGGNKPNMANGKSLKSVLQSSNRVPQTNPGVVEEDFPSLPACSGKSRPGQASKQSVWKPSGKSEPIKRDVVHSR---DNVVSVTAVEERPKVSVMSNQEFQ-QAKIHPIRTHQPVPDAELDFPSLAGNG----------KPSSNLSTANWARPA 1658
             C +  K ++ +    C+HP+C  CS +++   +        ++C IC+  +SK++      P+   +  N   L   +Y + F + +    +  ++   CPKC  P + + + +  H+ ++HK+ YCDLCV       +E   Y+  +   H          ++ HP C++C  R+ D   L +H++ +H+ C  C  +     Y    +L  H+  +HF+CE   C +   +  F +E   K H  +VH  SL  +         V +  G      +  Q   + R + DE   + + LP+  +    +   N E++FP L   + A S  L  P     RN +  + + +T+              T  TS     S + R  +    +A + K+              +S A  G++        L  V   S  VP+      + DFP+LP    K       +  +  PSG   P+       R   D+ VSV +     K+ ++  +E + +A+   ++   P   A  +FPSL  +           KPSS   + NW++PA
Sbjct:   47 ACVVCFKNVEIFSIGDCDHPVCYECSTRMRVLCQQ-------NECPICRHVLSKVLFTLDKLPYRELEANNRSDLYSKKYRIGFCTAEIRQQFFKLLDHPCPKCDAPPYRTFEGLRNHVRSEHKLLYCDLCVETLNIFTFERRCYTQAELQLHNTKGDPDNRSHRGHPLCEYCNKRYVDRDELFRHLRREHYFCHFCDADGCNEFYNDYADLAEHFRAEHFLCEEGKCATEQFVGAFRNEIEYKAHVANVHGKSLNKQQAKQTRTLQVEITLGPRGRSGQTEQGITSVRTRNDEHNDYQNDLPSITQRHVSIDAGN-EEQFPTLRGASTAPSVSLVRPPPPSMRNLSGTSGLARTKENFPALGGGNGGGVTGPTS----SSIAARAAQSQHPVAAVFKK-------------PTSAAGSGSRSGPPGNGMLLHVSNRSAAVPK-KAATPQVDFPALPGKGNKKNLRNLEEDML--PSGSPVPMANISAKHRSLADDYVSVASPSTFQKLQMVQKEEDEAKARQEALKKSAPKLTA-AEFPSLGPSASASSSRTTAPKPSSGSPSLNWSKPA 588
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
Match: znf598 (zinc finger protein 598 [Source:NCBI gene;Acc:407728])

HSP 1 Score: 135.961 bits (341), Expect = 4.232e-32
Identity = 68/251 (27.09%), Postives = 122/251 (48.61%), Query Frame = 3 
Query:   66 VCGLTDKEIDFYGFSYCNHPICGVCSIKLQKFSKDVGNDYDYSKCVICKQDISKIILASSIKPFESFDQTNLLCDTQYDLLFESTKAESYYKNVIKIKCPKCKMPH--NSMDDMILHMN-DHKMRYCDLCVTFNKCLHYELEIYSDNDYHQHR---------YKKHPKCKFCETRFYDDSHLIKHVKDKHFVCDICHRNHGCVAYKTQIELLRHYSMDHFVCE--ICRSSNNINVFESEYNLKTHKVSVHS 776
             C L  ++ID +    C+HP+C  CS K++     V  +  Y  C +C++ + K++     + F + +  +  C+ +YD+ F   K  + ++ ++  +CP C  P   +  +++  HM   H++  C LC+   K   YE + YS  D  +HR         ++ HP CKFC+ R+ D+  L+KH++  H+ C  C  +     Y     L  H+   H++CE   C +    + F +E + K HK + HS
Sbjct:   54 TCVLCCQDIDLFAVGKCDHPVCYRCSTKMR-----VLCEQKY--CAVCREQLDKVVFLRKPEAFATLNIHHYQCEKKYDIYFGDGKVHAQFRKILLNECPHCPEPKVFSKFEELEQHMRKQHELFCCKLCLKHLKIFSYERKWYSRKDLARHRMQGDPDDTSHRGHPLCKFCDDRYLDNDELLKHLRRDHYFCHFCDADGAQEYYSDYQYLSEHFRESHYLCEEGRCSTEQFTHAFRTEIDYKAHKAAAHS 297
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Match: znf598 (zinc finger protein 598 [Source:NCBI gene;Acc:779616])

HSP 1 Score: 134.806 bits (338), Expect = 1.422e-31
Identity = 77/251 (30.68%), Postives = 128/251 (51.00%), Query Frame = 3 
Query:   69 CGLTDKEIDFYGFSYCNHPICGVCSIKLQKFSKDVGNDYDYSKCVICKQDISKIILASSIKPFESFDQTNLLCDTQYDLLFESTKAESYYKNVIKIKCPKCK--MPHNSMDDMILHM-NDHKMRYCDLCVTFNKCLHYELEIYSDNDYHQHR---------YKKHPKCKFCETRFYDDSHLIKHVKDKHFVCDICHRNHGCVAYKTQIELLR-HYSMDHFVCEICRSSNN--INVFESEYNLKTHKVSVHS 776
            C L  +++D Y    C+HPIC  CS K++     V  +  Y  C +C++++ K++  + + PF S     L  + +YD+ FE  K  S ++ +++ +C  C    P ++  D+  HM  +H++  C LCV   K   YE   Y+  D  +HR         ++ HP CKFC+ R+ D+  L+KH++  H+ C  C  + G   Y ++   LR H+   HF+CE  R S     + F +E + K HK + HS
Sbjct:   15 CVLCCQDLDIYAVGKCDHPICYRCSTKMR-----VLCEQKY--CAVCREELDKVVFVNKLAPFTSLPLQQLQYEKKYDIYFEDGKLFSQFRKLLQHECTLCPSMRPFHAFADLEQHMRKNHELFCCKLCVRHLKNFTYERTWYTRRDLARHRIHGDPEDTSHRGHPLCKFCDERYLDNDELLKHLRRDHYFCHFCD-SEGAQEYYSEYSFLREHFRESHFLCEEGRCSTEQFTHAFPTEIDYKAHKTACHS 257
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Match: znf598 (zinc finger protein 598 [Source:NCBI gene;Acc:779616])

HSP 1 Score: 128.642 bits (322), Expect = 9.905e-30
Identity = 75/251 (29.88%), Postives = 127/251 (50.60%), Query Frame = 3 
Query:   69 CGLTDKEIDFYGFSYCNHPICGVCSIKLQKFSKDVGNDYDYSKCVICKQDISKIILASSIKPFESFDQTNLLCDTQYDLLFESTKAESYYKNVIKIKCPKCK--MPHNSMDDMILHM-NDHKMRYCDLCVTFNKCLHYELEIYSDNDYHQHR---------YKKHPKCKFCETRFYDDSHLIKHVKDKHFVCDICHRNHGCVAYKTQIELLR-HYSMDHFVCE--ICRSSNNINVFESEYNLKTHKVSVHS 776
            C L  +++D Y    C+HPIC  CS K++     V  +  Y  C +C++++ K++  + + PF S     L  + +YD+ FE  K   + + +++ +C  C    P ++  D+  HM  +H++  C LCV   K   YE   Y+  D  +HR         ++ HP CKFC+ R+ D+  L+KH++  H+ C  C  + G   Y ++   LR H+   HF+CE   C +    + F +E + K HK + HS
Sbjct:   15 CVLCCQDLDIYAVGKCDHPICYRCSTKMR-----VLCEQKY--CAVCREELDKVVFVNKLAPFTSLPLQQLQYEKKYDIYFEDGKL--FSQKLLQHECTLCPSMRPFHAFADLEQHMRKNHELFCCKLCVRHLKNFTYERTWYTRRDLARHRIHGDPEDTSHRGHPLCKFCDERYLDNDELLKHLRRDHYFCHFCD-SEGAQEYYSEYSFLREHFRESHFLCEEGRCSTEQFTHAFPTEIDYKAHKTACHS 255
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Mouse
Match: Zfp598 (zinc finger protein 598 [Source:MGI Symbol;Acc:MGI:2670965])

HSP 1 Score: 127.102 bits (318), Expect = 2.319e-29
Identity = 69/252 (27.38%), Postives = 119/252 (47.22%), Query Frame = 3 
Query:   69 CGLTDKEIDFYGFSYCNHPICGVCSIKLQKFSKDVGNDYDYSKCVICKQDISKIILASSIKPFESFDQTNLLCDTQYDLLFESTKAESYYKNVIKIKCPKCK--MPHNSMDDMILHMN-DHKMRYCDLCVTFNKCLHYELEIYSDNDYHQHR---------YKKHPKCKFCETRFYDDSHLIKHVKDKHFVCDICHRNHGCVAYKTQIELLRHYSMDHFVCEICRSSNN--INVFESEYNLKTHKVSVHSSS 782
            C L   +++      C+HP+C  CS K++          +   C +C++++ +++    +  F       L  + +YD+ F   K  + Y+ +++ +CP+C    P +   D+  HM   H++  C LC+   K   YE + YS  D  +HR         ++ HP CKFC+ R+ D+  L+KH++  H+ C  C  +     Y     L  H+   HF+CE  R S     + F +E +LK HK + HS S
Sbjct:   27 CVLCCGDLEATALGRCDHPVCYRCSTKMRVLC-------EQRYCAVCREELRQVVFGKKLPAFALIPIHQLQHEKKYDIYFADGKVFALYRQLLQHECPRCPHLPPFSLFGDLEQHMRKQHELFCCKLCLKHLKIFTYERKWYSRKDLARHRMQGDPDDTSHRGHPLCKFCDERYLDNDELLKHLRRDHYFCHFCDSDGAQDYYSDYAYLREHFREKHFLCEEGRCSTEQFTHAFRTEIDLKAHKTACHSRS 271
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Mouse
Match: Zfp598 (zinc finger protein 598 [Source:MGI Symbol;Acc:MGI:2670965])

HSP 1 Score: 127.102 bits (318), Expect = 2.434e-29
Identity = 69/252 (27.38%), Postives = 119/252 (47.22%), Query Frame = 3 
Query:   69 CGLTDKEIDFYGFSYCNHPICGVCSIKLQKFSKDVGNDYDYSKCVICKQDISKIILASSIKPFESFDQTNLLCDTQYDLLFESTKAESYYKNVIKIKCPKCK--MPHNSMDDMILHMN-DHKMRYCDLCVTFNKCLHYELEIYSDNDYHQHR---------YKKHPKCKFCETRFYDDSHLIKHVKDKHFVCDICHRNHGCVAYKTQIELLRHYSMDHFVCEICRSSNN--INVFESEYNLKTHKVSVHSSS 782
            C L   +++      C+HP+C  CS K++          +   C +C++++ +++    +  F       L  + +YD+ F   K  + Y+ +++ +CP+C    P +   D+  HM   H++  C LC+   K   YE + YS  D  +HR         ++ HP CKFC+ R+ D+  L+KH++  H+ C  C  +     Y     L  H+   HF+CE  R S     + F +E +LK HK + HS S
Sbjct:   27 CVLCCGDLEATALGRCDHPVCYRCSTKMRVLC-------EQRYCAVCREELRQVVFGKKLPAFALIPIHQLQHEKKYDIYFADGKVFALYRQLLQHECPRCPHLPPFSLFGDLEQHMRKQHELFCCKLCLKHLKIFTYERKWYSRKDLARHRMQGDPDDTSHRGHPLCKFCDERYLDNDELLKHLRRDHYFCHFCDSDGAQDYYSDYAYLREHFREKHFLCEEGRCSTEQFTHAFRTEIDLKAHKTACHSRS 271
[Close]
BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q86UK7|ZN598_HUMAN (E3 ubiquitin-protein ligase ZNF598 OS=Homo sapiens OX=9606 GN=ZNF598 PE=1 SV=1)

HSP 1 Score: 127.872 bits (320), Expect = 9.313e-29
Identity = 67/252 (26.59%), Postives = 120/252 (47.62%), Query Frame = 3 
Query:   69 CGLTDKEIDFYGFSYCNHPICGVCSIKLQKFSKDVGNDYDYSKCVICKQDISKIILASSIKPFESFDQTNLLCDTQYDLLFESTKAESYYKNVIKIKCPKCK--MPHNSMDDMILHMN-DHKMRYCDLCVTFNKCLHYELEIYSDNDYHQHR---------YKKHPKCKFCETRFYDDSHLIKHVKDKHFVCDICHRNHGCVAYKTQIELLRHYSMDHFVCEICRSSNN--INVFESEYNLKTHKVSVHSSS 782
            C L   +++      C+HP+C  CS K++          +   C +C++++ +++    +  F +     L  + +YD+ F   K  + Y+ +++ +CP+C    P +   D+  HM   H++  C LC+   +   YE + YS  D  +HR         ++ HP CKFC+ R+ D+  L+KH++  H+ C  C  +     Y     L  H+   HF+CE  R S     + F +E +LK H+ + HS S
Sbjct:   29 CVLCCGDLEATALGRCDHPVCYRCSTKMRVLC-------EQRYCAVCREELRQVVFGKKLPAFATIPIHQLQHEKKYDIYFADGKVYALYRQLLQHECPRCPELPPFSLFGDLEQHMRRQHELFCCRLCLQHLQIFTYERKWYSRKDLARHRMQGDPDDTSHRGHPLCKFCDERYLDNDELLKHLRRDHYFCHFCDSDGAQDYYSDYAYLREHFREKHFLCEEGRCSTEQFTHAFRTEIDLKAHRTACHSRS 273
[Close]
BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q80YR4|ZN598_MOUSE (E3 ubiquitin-protein ligase ZNF598 OS=Mus musculus OX=10090 GN=Znf598 PE=1 SV=1)

HSP 1 Score: 127.102 bits (318), Expect = 1.702e-28
Identity = 69/252 (27.38%), Postives = 119/252 (47.22%), Query Frame = 3 
Query:   69 CGLTDKEIDFYGFSYCNHPICGVCSIKLQKFSKDVGNDYDYSKCVICKQDISKIILASSIKPFESFDQTNLLCDTQYDLLFESTKAESYYKNVIKIKCPKCK--MPHNSMDDMILHMN-DHKMRYCDLCVTFNKCLHYELEIYSDNDYHQHR---------YKKHPKCKFCETRFYDDSHLIKHVKDKHFVCDICHRNHGCVAYKTQIELLRHYSMDHFVCEICRSSNN--INVFESEYNLKTHKVSVHSSS 782
            C L   +++      C+HP+C  CS K++          +   C +C++++ +++    +  F       L  + +YD+ F   K  + Y+ +++ +CP+C    P +   D+  HM   H++  C LC+   K   YE + YS  D  +HR         ++ HP CKFC+ R+ D+  L+KH++  H+ C  C  +     Y     L  H+   HF+CE  R S     + F +E +LK HK + HS S
Sbjct:   27 CVLCCGDLEATALGRCDHPVCYRCSTKMRVLC-------EQRYCAVCREELRQVVFGKKLPAFALIPIHQLQHEKKYDIYFADGKVFALYRQLLQHECPRCPHLPPFSLFGDLEQHMRKQHELFCCKLCLKHLKIFTYERKWYSRKDLARHRMQGDPDDTSHRGHPLCKFCDERYLDNDELLKHLRRDHYFCHFCDSDGAQDYYSDYAYLREHFREKHFLCEEGRCSTEQFTHAFRTEIDLKAHKTACHSRS 271
[Close]
BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q6PFK1|ZN598_DANRE (E3 ubiquitin-protein ligase ZNF598 OS=Danio rerio OX=7955 GN=znf598 PE=1 SV=2)

HSP 1 Score: 126.331 bits (316), Expect = 3.479e-28
Identity = 68/251 (27.09%), Postives = 122/251 (48.61%), Query Frame = 3 
Query:   66 VCGLTDKEIDFYGFSYCNHPICGVCSIKLQKFSKDVGNDYDYSKCVICKQDISKIILASSIKPFESFDQTNLLCDTQYDLLFESTKAESYYKNVIKIKCPKCKMPH--NSMDDMILHM-NDHKMRYCDLCVTFNKCLHYELEIYSDNDYHQHR---------YKKHPKCKFCETRFYDDSHLIKHVKDKHFVCDICHRNHGCVAYKTQIELLRHYSMDHFVCE--ICRSSNNINVFESEYNLKTHKVSVHS 776
             C L  ++ID +    C+HP+C  CS K++     V  +  Y  C +C++ + K++     + F + +  +  C+ +YD+ F   K  + ++ ++  +CP C  P   +  +++  HM   H++  C LC+   K   YE + YS  D  +HR         ++ HP CKFC+ R+ D+  L+KH++  H+ C  C  +     Y     L  H+   H++CE   C +    + F +E + K HK + HS
Sbjct:   56 TCVLCCQDIDLFAVGKCDHPVCYRCSTKMR-----VLCEQKY--CAVCREQLDKVVFLRKPEAFATLNIHHYQCEKKYDIYFGDGKVHAQFRKILLNECPHCPEPKVFSKFEELEQHMRKQHELFCCKLCLKHLKIFSYERKWYSRKDLARHRMQGDPDDTSHRGHPLCKFCDDRYLDNDELLKHLRRDHYFCHFCDADGAQEYYSDYQYLSEHFRESHYLCEEGRCSTEQFTHAFRTEIDYKAHKAAAHS 299
[Close]
BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q76PD2|HEL2_SCHPO (E3 ubiquitin-protein ligase hel2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPCC1223.01 PE=1 SV=2)

HSP 1 Score: 97.4413 bits (241), Expect = 2.651e-19
Identity = 71/271 (26.20%), Postives = 117/271 (43.17%), Query Frame = 3 
Query:   57 DCPVCGLTDKEIDFYGFSYCNHPICGVCSIKLQKFSKDVGNDYDYSKCVICKQDISKIILASSIK-PFESFDQTNL-LCDTQYDLLFESTKAESYYKNVIKIKCPK--CKMPHNSMDDMILHMN-DHKMRYCDLCVTFNKCLHYELEIYSDNDYHQHR-------------YKKHPKCKFCETRFYDDSHLIKHVKDKHFVCDICHRNHGCVA---YKTQIELLRHYSMDHFVC--EICRSSNNINVFESEYNLKTHKVSVHSSSLVGEGL 800
            D  +C +  + I +     CNH +C VC+++L+         Y   +C  CK +   +++    +      D   L   D +  +++    A+     +++  CP+  C +      D+ LH    H   +CDLCV   K   +E  ++S     +H              +K HPKC+FC T FYDD  L KH ++KH  C IC +  G      +K    L RH+  DH++C    C     + VF +E +LK H++  H  +     L
Sbjct:   77 DEQICFICAEGITYSCVLPCNHRMCHVCALRLRAL-------YKTKECTFCKTEWDTVLITKDHEIDIHDVDLAKLPFQDEKLGIVYSDEHAQEESNLLLQFNCPEDACDITCKGWFDLKLHAKVKHHKFFCDLCVKNKKVFTHEHTLFSKKGLTKHNEVGDQGSDLEITGFKGHPKCEFCNTHFYDDDELFKHCREKHERCYICDQVAGRPTHQYFKNYDSLERHFEKDHYICRERECLERKFV-VFGTEIDLKAHQLDEHPHNFTQREL 339
[Close]
BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q05580|HEL2_YEAST (E3 ubiquitin-protein ligase HEL2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=HEL2 PE=1 SV=1)

HSP 1 Score: 82.8037 bits (203), Expect = 6.889e-15
Identity = 65/261 (24.90%), Postives = 115/261 (44.06%), Query Frame = 3 
Query:   66 VCGLTDKEIDFYGFSYCNHPICGVCSIKLQKFSKDVGNDYDYSKCVICKQDISKIILASSIKPFESFDQTNLLCDT--QYDLLFESTKAESYYKNVIKIKCPKCKMPH----NSMDDMILHM-NDHKMRYCDLCVTFNKCLHYELEIYSDNDYHQHR-------YKKHPKCKFCE-TRFYDDSHLIKHVKDKHFVCDICHRNHGCVA--YKTQIELLRHYSMDHFVCEICRS-SNNINVFESEYNLKTHKVSVHSSSLVGE 794
            +C +  +++ +   + C+H  C +C  + +         Y+   C+IC+ +  +++    I    S D+ N  C+   +Y + F S +  +   N++K  CP  K        S      H+ ++H    C +C T       ELEI++ N    H+       +K HP C FC   RFY D  L  H++++H  C IC + +      +K   +L  H+   H+VC +     N   VF+ E  L+ H +  H + L G+
Sbjct:   63 LCVICARKLTYVSLTPCHHKTCHICGFRQRAL-------YNKKSCLICRTENEEVMFTDRIDGDIS-DKYNF-CEKNEKYGINFTSEEVATETLNLLKFFCPLSKDEQVCDFGSFKKYNEHLKSEHNRMICLICATHKHAFPCELEIFTQNQLRNHQTKGNSEGFKGHPMCAFCSGKRFYSDDELYIHMRNQHEKCHICDKMNPASPQYFKDYNQLFDHFKHSHYVCTVQTCLDNKFVVFKDELELQAHILQEHGNILKGK 314
[Close]
BLAST of RING-type domain-containing protein vs. TrEMBL
Match: A0A4S2MAB4 (RING-type domain-containing protein OS=Opisthorchis felineus OX=147828 GN=CRM22_001493 PE=4 SV=1)

HSP 1 Score: 199.904 bits (507), Expect = 1.517e-49
Identity = 139/518 (26.83%), Postives = 235/518 (45.37%), Query Frame = 3 
Query:   66 VCGLTDKEIDFYGFSYCNHPICGVCSIKLQKFSKDVGNDYDYSKCVICKQDISKIILASSIKPFESFDQTNLLCDTQYDLLFESTKAESYYKNVIKIKCPKCKMPHNSMDDMILHMN-DHKMRYCDLCVTFNKCLHYEL------EIYSDNDYHQHRYKKHPKCKFCETRFYDDSHLIKHVKDKHFVCDICHRNHGCVAYKTQIELLRHYSMDHFVCEICRSSNNINVFESEYNLKTHKVSVHSSSLVGE--GLVTVGF----------------GDNRDNQRYGNRRRQRDEDAFFVDSLPTAMEIPQVLPTFNCEQEFPRLGADAVASSQQLGVPSLTLDRNDARAAFIDQTETVMSEKETNKIQMTTAATSQANVGSSSNRHEKMSDNIAIMVKRSAGSLNSEDFPSL-SSSLATGGNKPNMANGKSL-KSVLQSSN----RVPQTNPGVVEEDFPSLPACSGKSRPGQASKQSVWKPSGKSEP--IKRDVVHSRDNVVSVTAVEERPKVSVMSN 1520
            VC +  ++IDFY +  CNHP C  C +KL+KF     ++ D+SKC  C+Q+I+K+++     PF++   + +  D QYD +F + + E +Y++++K  CP C     S+  +  H   +H++ YCDLC+ +++ L  E        +     + + R + HP C FCE RFY+   LI H++D+HF+CD+C        ++ Q ELL+HYS  H +C  CR+   I+ F +   L  H+   H + +  +    + V                  G +    R G   R  D      +     +   +V P+     +FP LGA    S+ Q    + T D +    + +  T +  + + T            A + S + R  +               L ++DFPSL  S+++   +   +   KSL +   QSSN    R  Q  P   ++DFP LPA +G++   +      W PS   +P  ++  V  S  N +   +   RP V + S+
Sbjct:   11 VCSVCHEDIDFYAYGACNHPTCTKCILKLRKFGS--ADEPDFSKCPTCRQNINKVLIMKDFVPFDNVVTSEMRHDPQYDFIFPTQEIEKHYRDMLKSYCPICGEEKMSLSALNRHTTLEHQLSYCDLCIRYSRLLPCEFVPMKPTALAEHRKWDKQRKRGHPLCDFCEERFYEMEDLISHIRDRHFLCDLCMTTGKFEVFREQWELLQHYSDAHHLCAECRAQQRISCFLTSDRLGLHRFQEHPNEVANDPNSWLPVSIQLPPREAASPRRYDSSGTHTGIDRVGGYLRASD-GTLVAEGTGAGVRFRRVNPSEWTGDDFPTLGAG--GSTNQQPAAASTRDSHSRPQSGVPVTTSASTPRPT------------ATLASVAGRGRQ-------------NQLTADDFPSLPGSNVSPKASSQPLWKAKSLSQPASQSSNTAASRTQQVKP--TQQDFPGLPA-TGRTALSRDPVSDNWGPSTHEQPSSVRLGVDQSSSNRIQQPS---RPVVPLASD 492
[Close]
BLAST of RING-type domain-containing protein vs. TrEMBL
Match: A0A4S2MAD7 (RING-type domain-containing protein OS=Opisthorchis felineus OX=147828 GN=CRM22_001493 PE=4 SV=1)

HSP 1 Score: 200.29 bits (508), Expect = 1.518e-49
Identity = 139/518 (26.83%), Postives = 235/518 (45.37%), Query Frame = 3 
Query:   66 VCGLTDKEIDFYGFSYCNHPICGVCSIKLQKFSKDVGNDYDYSKCVICKQDISKIILASSIKPFESFDQTNLLCDTQYDLLFESTKAESYYKNVIKIKCPKCKMPHNSMDDMILHMN-DHKMRYCDLCVTFNKCLHYEL------EIYSDNDYHQHRYKKHPKCKFCETRFYDDSHLIKHVKDKHFVCDICHRNHGCVAYKTQIELLRHYSMDHFVCEICRSSNNINVFESEYNLKTHKVSVHSSSLVGE--GLVTVGF----------------GDNRDNQRYGNRRRQRDEDAFFVDSLPTAMEIPQVLPTFNCEQEFPRLGADAVASSQQLGVPSLTLDRNDARAAFIDQTETVMSEKETNKIQMTTAATSQANVGSSSNRHEKMSDNIAIMVKRSAGSLNSEDFPSL-SSSLATGGNKPNMANGKSL-KSVLQSSN----RVPQTNPGVVEEDFPSLPACSGKSRPGQASKQSVWKPSGKSEP--IKRDVVHSRDNVVSVTAVEERPKVSVMSN 1520
            VC +  ++IDFY +  CNHP C  C +KL+KF     ++ D+SKC  C+Q+I+K+++     PF++   + +  D QYD +F + + E +Y++++K  CP C     S+  +  H   +H++ YCDLC+ +++ L  E        +     + + R + HP C FCE RFY+   LI H++D+HF+CD+C        ++ Q ELL+HYS  H +C  CR+   I+ F +   L  H+   H + +  +    + V                  G +    R G   R  D      +     +   +V P+     +FP LGA    S+ Q    + T D +    + +  T +  + + T            A + S + R  +               L ++DFPSL  S+++   +   +   KSL +   QSSN    R  Q  P   ++DFP LPA +G++   +      W PS   +P  ++  V  S  N +   +   RP V + S+
Sbjct:   11 VCSVCHEDIDFYAYGACNHPTCTKCILKLRKFGS--ADEPDFSKCPTCRQNINKVLIMKDFVPFDNVVTSEMRHDPQYDFIFPTQEIEKHYRDMLKSYCPICGEEKMSLSALNRHTTLEHQLSYCDLCIRYSRLLPCEFVPMKPTALAEHRKWDKQRKRGHPLCDFCEERFYEMEDLISHIRDRHFLCDLCMTTGKFEVFREQWELLQHYSDAHHLCAECRAQQRISCFLTSDRLGLHRFQEHPNEVANDPNSWLPVSIQLPPREAASPRRYDSSGTHTGIDRVGGYLRASD-GTLVAEGTGAGVRFRRVNPSEWTGDDFPTLGAG--GSTNQQPAAASTRDSHSRPQSGVPVTTSASTPRPT------------ATLASVAGRGRQ-------------NQLTADDFPSLPGSNVSPKASSQPLWKAKSLSQPASQSSNTAASRTQQVKP--TQQDFPGLPA-TGRTALSRDPVSDNWGPSTHEQPSSVRLGVDQSSSNRIQQPS---RPVVPLASD 492
[Close]
BLAST of RING-type domain-containing protein vs. TrEMBL
Match: A0A4E0RJ14 (Suppressor of SWI4 1 OS=Fasciola hepatica OX=6192 GN=D915_008194 PE=4 SV=1)

HSP 1 Score: 192.586 bits (488), Expect = 2.832e-46
Identity = 131/477 (27.46%), Postives = 219/477 (45.91%), Query Frame = 3 
Query:   60 CPVCGLTDKEIDFYGFSYCNHPICGVCSIKLQKFSKDVGNDYDYSKCVICKQDISKIILASSIKPFESFDQTNLLCDTQYDLLFESTKAESYYKNVIKIKCPKCKMPHNSMDDMILHMN-DHKMRYCDLCVTFNKCLHYEL------EIYSDNDYHQHRYKKHPKCKFCETRFYDDSHLIKHVKDKHFVCDICHRNHGCVAYKTQIELLRHYSMDHFVCEICRSSNNINVFESEYNLKTHKVSVHSSSLVG--EGLVTVGFGDNRDNQRYGNRRR---QRDED-----------AFFVDSLPTAMEIPQVLPTFNCEQEFPRLGADAVASSQQLGVPSLTLDRNDARAAFIDQTETVMSEKETNKIQMTTAATSQA-NVGSSSNRHEKMSDNIAIMVKRSAGS-LNSEDFPSLSSS----LATG---------GNKPNMANGKSLKSVLQSSNRVPQTNPGVVEEDFPSLPACSGKS 1376
            CP+C    ++IDF+ +  CNHP C  C +KL+KF     ++ D+SKC  C+++++KI++  S  PF   + + +  D +YD ++ S   E YY+++++  CP C     S+  +  H   +H++ YCDLC+ + + L  E       ++ +   +   R + HP C FC+  FY+   LI H++D HF+CD+C  +   V ++ Q ELL HY   H +C  CR    I+ F +  NL  H+   H  ++    +  + +     R++    +RRR   ++D D               +     +   +  P+     +FP L A     SQ    P+        R+A +  T+    +  T         T QA N  S+S    +    +A +  R   + L ++DFPSLS+S    +AT          G +  + NG       Q+  R  QT       DFP+LP  SG+S
Sbjct:   14 CPIC---HEDIDFFAYGACNHPTCTKCILKLRKFGS--VDEPDFSKCPTCRRNLNKIVIMESFVPFNQVNTSTMRHDAKYDFVYPSQHIERYYRDMLRSICPVCGEEKISLSALNRHTTMEHQLSYCDLCIRYARLLPCEFVPMKPADLVAHRKWDNQRKRGHPSCDFCKELFYEFEDLIHHLRDSHFLCDLCRPSGEFVVFREQCELLTHYGEAHHLCAECRQQQRISCFSTAENLGLHRFQEHPDAVNNDPDSWMPISIELARNSDIVAHRRRDPLRQDIDHVGGVLDSTDGRLVAEGTQAGVRFRRPNPSEWTGDDFPALAASGAPGSQP---PT-------ERSASVSGTQASTGDSPT---------TRQADNARSASRTAGQPGITLAALTGRGRSTRLTADDFPSLSNSGTVNVATAPTWIKTSSIGARSPVTNGTG----QQNQPRPKQTQQRPTASDFPNLPHESGRS 462
[Close]
BLAST of RING-type domain-containing protein vs. TrEMBL
Match: A0A5K4FFL7 (Uncharacterized protein OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 186.808 bits (473), Expect = 6.325e-45
Identity = 119/430 (27.67%), Postives = 200/430 (46.51%), Query Frame = 3 
Query:   60 CPVCGLTDKEIDFYGFSYCNHPICGVCSIKLQKFSKDVGNDYDYSKCVICKQDISKIILASSIKPFESFDQTNLLCDTQYDLLFESTKAESYYKNVIKIKCPKCKMPHNSMDDMILHMN-DHKMRYCDLCVTFNKCLHYELEIYSDNDYHQHR------YKKHPKCKFCETRFYDDSHLIKHVKDKHFVCDICHRNHGCVAYKTQIELLRHYSMDHFVCEICRSSNNINVFESEYNLKTHKVSVHSSSLVGE--GLVTVGFGDNRDNQRYGNRRRQRDEDAFFVDSLP-------TAMEIPQVL-----PTFNCEQEFPRLGA------DAVASSQQLGVPSLTLDRNDARAAFIDQTETVMSEKETNKIQMTTAATSQANVGSSSNRHEKMSDNIAIMVKRSAGSLNSEDFPSLSSSL-ATGGNKPNMA 1265
            CP+C     +ID+Y +  CNHP C  C +KL+KF     ++ ++S+C  C+Q+I+++ +  +  PF++ D + L  D+++D +F   + E +Y N++K  CP C     S+  +  H   +H++ YCDLC+ + + L  E  +    D  +HR       K HP C FC+ RFY+   LI H++D HF+CD+C      V ++ Q ELL HY   H +C  CR+   I+ F +E  L  H+   H + +  +    + +             RR Q   D + VD +        T+ + P V      P+    ++FP L +       + +++ +   P   + R    AA        ++E+E N    +         GS  +R       +A +   +   L SEDFPSL+ S   + GN P   
Sbjct:   12 CPICH---DDIDYYAYGSCNHPTCTKCVLKLRKFGS--ADEPEFSQCPTCRQNINRVAIMRNFVPFDNIDVSLLRHDSKFDFMFPDVEIEQHYVNMLKSICPVCGEEKKSLSALNRHTTLEHQLSYCDLCIRYARLLPCEFVLMKPADLAKHRSWDKNKKKGHPLCDFCQERFYEMEDLITHIRDLHFLCDLCMTTGKFVVFRQQCELLDHYGESHHLCSECRAQQRISCFATEDRLGLHRFQEHPNEVANDPNSWLPISIRHVTSTDSAFRRRDQIFPDVYSVDGVVDASDGRLTSQDNPSVTYRRPNPSEWTGEDFPSLQSTRPVTTSSHSTTNESSSPQAPIQRLKESAA-------SLTEREVNDTNNSVQNKRPITGGSWVSR-------VANINFTNKDRLTSEDFPSLTQSPNPSTGNPPTWV 422
[Close]
BLAST of RING-type domain-containing protein vs. TrEMBL
Match: A0A4Z2DXC2 (E3 ubiquitin-protein isoform 1 OS=Schistosoma japonicum OX=6182 GN=EWB00_010387 PE=4 SV=1)

HSP 1 Score: 181.03 bits (458), Expect = 8.739e-44
Identity = 117/446 (26.23%), Postives = 203/446 (45.52%), Query Frame = 3 
Query:   69 CGLTDKEIDFYGFSYCNHPICGVCSIKLQKFSKDVGNDYDYSKCVICKQDISKIILASSIKPFESFDQTNLLCDTQYDLLFESTKAESYYKNVIKIKCPKCKMPHNSMDDMILHM-NDHKMRYCDLCVTFNKCLHYELEIYSDNDYHQHRY------KKHPKCKFCETRFYDDSHLIKHVKDKHFVCDICHRNHGCVAYKTQIELLRHYSMDHFVCEICRSSNNINVFESEYNLKTHKVSVHSSSLVG--EGLVTVGFGDNRDNQRYGNRRRQRDEDAFFVDSLPTAMEIPQVLPTFNCEQEFPRLGADAVASSQQLGVPSLTLDRNDARAAFIDQTETVMSEKETNKIQMTTAATSQANVGSSSNRHEKMSDNIAIMVKRSAG-------SLNSEDFPSLSSSL-ATGGNKPNMANGKSLKSVLQSSNRVPQTNPGVVEEDFPSL 1355
            C +  ++ID++ +  CNHP C  C +KL+KF     ++ ++SKC  C+Q+I+++++  +  PF++ D + L  D ++D +F   + E +Y N++K  CP C     S+  +  H  ++H++ YCDLC+ + + L  E  +    D  +HR       K HP C FC+ RFY+   LI H++D HF+CD+C      V ++ Q ELL HY   H +C  CR+   I+ F +   L  H+   H + +    +  + +             RR Q   D + V  +  A    +++   N    + R              PSL   R+   ++ +   E+   +      +  T+A+++    +++N   K        V R +         L SEDFPSL+ S   + GN P      + +S+          NP      FP+L
Sbjct:   13 CSVCHEDIDYFAYGSCNHPTCTKCVLKLRKFGS--ADEPEFSKCPTCRQNINRVVIMRTFVPFDNIDVSVLRHDPRFDFMFPDKEIEQHYSNMLKSTCPVCGEEKKSLSALNRHTTSEHQLSYCDLCIRYARLLPCEFVLMKPLDLTKHRSWDKNKKKGHPLCDFCQERFYELEDLIIHIRDIHFLCDLCMTTGKFVVFRQQCELLDHYGDSHHLCSECRAQQRISCFATADRLGLHRFQEHPNEVANDPDSWLPISIRHVTTTDSAFRRRDQIFPDVYSVGGV-LAGSDGRLISEDNTNLTYRRPNPSEWTGED---FPSLQSTRSGVVSSHLTTDESNSPQTAAQSPKELTSASTERKGETTNNVQNKRPTVGGSWVSRVSNVNFTNKDRLTSEDFPSLTQSPNPSTGNPPTWVRSGASQSI---------QNPQTSNHAFPAL 443
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
Match: znf598 (zinc finger protein 598 [Source:NCBI gene;Acc:103035537])

HSP 1 Score: 127.487 bits (319), Expect = 1.679e-29
Identity = 67/253 (26.48%), Postives = 119/253 (47.04%), Query Frame = 3 
Query:   66 VCGLTDKEIDFYGFSYCNHPICGVCSIKLQKFSKDVGNDYDYSKCVICKQDISKIILASSIKPFESFDQTNLLCDTQYDLLFESTKAESYYKNVIKIKCPKCKMPH--NSMDDMILHM-NDHKMRYCDLCVTFNKCLHYELEIYSDNDYHQHR---------YKKHPKCKFCETRFYDDSHLIKHVKDKHFVCDICHRNHGCVAYKTQIELLRHYSMDHFVCE--ICRSSNNINVFESEYNLKTHKVSVHSSS 782
             C L  ++I+ +    C+HP+C  CS K++          +   C +C++++ K+I    +KPF +        + +YD+ F   K  + ++ ++  +CP C      +  +++  HM   H++  C LC    K   YE + Y+  D  +HR         ++ HP CKFC+ R+ D+  L+KH++  HF C  C  +     Y     L  H+   H++CE   C +    + F +E + K HK + HS S
Sbjct:   13 TCVLCCQDIEIFAVGKCDHPVCYRCSTKMRVLC-------EQRYCAVCREELDKVIFVRKLKPFAALPHHEYQSEKKYDIYFSDGKIFAQFRRILLFECPHCPESKVFSKFEELEQHMRKQHELFCCKLCAKHLKIFAYERKWYNRKDLARHRTQGDPDDTSHRGHPLCKFCDDRYLDNDELLKHLRRDHFFCHFCDADGAQEYYSDYQYLSEHFRESHYLCEEGRCSTEQFTHAFRTEIDYKAHKAAAHSKS 258
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Yeast
Match: HEL2 (RING finger ubiquitin ligase (E3); involved in ubiquitination and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; computational analysis suggests a role as a transcription factor [Source:SGD;Acc:S000002674])

HSP 1 Score: 82.8037 bits (203), Expect = 9.921e-17
Identity = 65/261 (24.90%), Postives = 115/261 (44.06%), Query Frame = 3 
Query:   66 VCGLTDKEIDFYGFSYCNHPICGVCSIKLQKFSKDVGNDYDYSKCVICKQDISKIILASSIKPFESFDQTNLLCDT--QYDLLFESTKAESYYKNVIKIKCPKCKMPH----NSMDDMILHM-NDHKMRYCDLCVTFNKCLHYELEIYSDNDYHQHR-------YKKHPKCKFCE-TRFYDDSHLIKHVKDKHFVCDICHRNHGCVA--YKTQIELLRHYSMDHFVCEICRS-SNNINVFESEYNLKTHKVSVHSSSLVGE 794
            +C +  +++ +   + C+H  C +C  + +         Y+   C+IC+ +  +++    I    S D+ N  C+   +Y + F S +  +   N++K  CP  K        S      H+ ++H    C +C T       ELEI++ N    H+       +K HP C FC   RFY D  L  H++++H  C IC + +      +K   +L  H+   H+VC +     N   VF+ E  L+ H +  H + L G+
Sbjct:   63 LCVICARKLTYVSLTPCHHKTCHICGFRQRAL-------YNKKSCLICRTENEEVMFTDRIDGDIS-DKYNF-CEKNEKYGINFTSEEVATETLNLLKFFCPLSKDEQVCDFGSFKKYNEHLKSEHNRMICLICATHKHAFPCELEIFTQNQLRNHQTKGNSEGFKGHPMCAFCSGKRFYSDDELYIHMRNQHEKCHICDKMNPASPQYFKDYNQLFDHFKHSHYVCTVQTCLDNKFVVFKDELELQAHILQEHGNILKGK 314
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Match: EDO40042 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S8C4])

HSP 1 Score: 109.383 bits (272), Expect = 1.887e-26
Identity = 67/257 (26.07%), Postives = 123/257 (47.86%), Query Frame = 3 
Query:   66 VCGLTDKEIDFYGFSYCNHPICGVCSIKLQKFSKDVGNDYDYSKCVICKQDISKIILASSIKPFESFDQTNL--LCDTQYDLLFESTKAESYYKNVIKIKCPKC--KMPHNSMDDMILHMND-HKMRYCDLCVTFNKCLHYELEIYSDNDYHQHR---------YKKHPKCKFCETRFYDDSHLIKHVKDKHFVCDICHRNHGCVAYKTQIELLRHYSMDHFVCE--ICRSSNNINVFESEYNLKTHKVSVHSSSLV 788
            +C +  +EI+F     C+HP+C  C ++++   ++       + C +C+ ++S + L +   P+ S  +  L  L D +Y + +E+ +     K +++ +C  C  + P  +   +  HM   H++ +C LCV       +E + Y+  D  +HR         +K HP C+FC+ RF D+  L  H++  HF C  C  +   + Y     L  H+  DH +CE   CR     NVF ++ +L+ H+ + H   L 
Sbjct:   13 LCVVCCEEIEFSAVGKCDHPVCYKCCVRMRVLKQE-------NYCTVCRSELSMVYLVAHPAPWVSMKEKALKGLSDKKYGIYYETKEIRDNVKFLLEHRCYICPEQRPFQTFKKLEDHMRQTHQLYFCALCVKHYTKFSHERKAYTRQDLARHRRIGDSDDKSHKGHPLCQFCDERFLDNDELHGHLRKNHFWCHFCETDGKQLYYNDYPNLREHFRHDHLLCEEDECRFEQFTNVFRTDIDLQAHRANKHGRKLT 262
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Medaka
Match: znf598 (zinc finger protein 598 [Source:NCBI gene;Acc:101162451])

HSP 1 Score: 129.413 bits (324), Expect = 3.729e-30
Identity = 107/474 (22.57%), Postives = 196/474 (41.35%), Query Frame = 3 
Query:   66 VCGLTDKEIDFYGFSYCNHPICGVCSIKLQKFSKDVGNDYDYSKCVICKQDISKIILASSIKPFESFDQTNLLCDTQYDLLFESTKAESYYKNVIKIKCPKCKMPHN--SMDDMILHMN-DHKMRYCDLCVTFNKCLHYELEIYSDNDYHQHR---------YKKHPKCKFCETRFYDDSHLIKHVKDKHFVCDICHRNHGCVAYKTQIELLRHYSMDHFVCE--ICRSSNNINVFESEYNLKTHKVSVHSSSLVGEGLVTVGFGDNRDNQR------YGNRRRQRDEDAFFVDSLPTAMEIPQVLPTFNCEQEFPRLGADAVASSQQLGV---PSLTLDRNDARAAFIDQTETVMSEKETNKIQMTTAATSQANVGSSS-NRHEKMS--------DNIAIM--------VKRS----AGSLNSEDFPSLSSSLATGGNKPNMANGKSLKSVLQSSNRVPQTNPGVVEEDFPSL 1355
             C L  ++++ +    C+HP+C  CS K++     V  +  Y  C +C++++ K++    ++ F+S    N  C+  YD+ F      S Y+ ++  +CP+C  P    + +++  HM   H++  C LC    K   +E + Y+  +  +HR         ++ HP CKFC+ R+ D+  L+KH++  H+ C  C  +     Y     L  H+   H++CE   C +    + F SE + K HK + HS +            + R N++      Y  R+++R+E     +      +           Q+  R   +     +Q+      S+ + R   RAA   Q  +       +++  T     +AN G  + NR    +        D   ++        VK +    A +L  E++PSLS++  +    P  +      S  Q             EEDFP+L
Sbjct:   10 TCVLCCQDVEIFALGKCDHPVCYRCSTKMR-----VLCEQKY--CAVCREELDKVVFVKKLEAFQSLSYQNFPCEKTYDIYFGDEMIYSQYRRLLFSECPRCPEPKIFCTFEELEKHMRKQHELFCCKLCTKHLKIFSHERKWYNRKELARHRAHGDTDDTSHRGHPLCKFCDDRYLDNDELLKHLRRDHYFCHFCDADGSQEYYSDYQYLSEHFRESHYLCEEGRCATEQFTHAFRSEIDYKAHKAAAHSKNR----------AEARQNRQIELQFNYATRQQRRNEGMLTGEDYEEMRQNRGGRGRPPGGQKSWRYSREREEEDRQVEAALRASMAMRRQAERAAV--QERSTPKHCREDRVDRTEPEEPKANTGHKTVNRPPVKTLKSSNPGDDEFPVLGATALIPSVKPASVGGAATLKEEEYPSLSAAAVSAPMTPAYSAQPRKTSSFQ-------------EEDFPAL 451
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Medaka
Match: znf598 (zinc finger protein 598 [Source:NCBI gene;Acc:101162451])

HSP 1 Score: 81.2629 bits (199), Expect = 3.685e-15
Identity = 84/385 (21.82%), Postives = 152/385 (39.48%), Query Frame = 3 
Query:  333 YYKNVIKIKCPKCKMPHN--SMDDMILHM-NDHKMRYCDLCVTFNKCLHYELEIYSDNDYHQHR---------YKKHPKCKFCETRFYDDSHLIKHVKDKHFVCDICHRNHGCVAYKTQIELLRHYSMDHFVCE--ICRSSNNINVFESEYNLKTHKVSVHSSSLVGEGLVTVGFGDNRDNQR------YGNRRRQRDEDAFFVDSLPTAMEIPQVLPTFNCEQEFPRLGADAVASSQQLGV---PSLTLDRNDARAAFIDQTETVMSEKETNKIQMTTAATSQANVGSSS-NRHEKMS--------DNIAIM--------VKRS----AGSLNSEDFPSLSSSLATGGNKPNMANGKSLKSVLQSSNRVPQTNPGVVEEDFPSL 1355
            + + ++  +CP+C  P    + +++  HM   H++  C LC    K   +E + Y+  +  +HR         ++ HP CKFC+ R+ D+  L+KH++  H+ C  C  +     Y     L  H+   H++CE   C +    + F SE + K HK + HS +            + R N++      Y  R+++R+E     +      +           Q+  R   +     +Q+      S+ + R   RAA   Q  +       +++  T     +AN G  + NR    +        D   ++        VK +    A +L  E++PSLS++  +    P  +      S  Q             EEDFP+L
Sbjct:  102 HSRRLLFSECPRCPEPKIFCTFEELEKHMRKQHELFCCKLCTKHLKIFSHERKWYNRKELARHRAHGDTDDTSHRGHPLCKFCDDRYLDNDELLKHLRRDHYFCHFCDADGSQEYYSDYQYLSEHFRESHYLCEEGRCATEQFTHAFRSEIDYKAHKAAAHSKNR----------AEARQNRQIELQFNYATRQQRRNEGMLTGEDYEEMRQNRGGRGRPPGGQKSWRYSREREEEDRQVEAALRASMAMRRQAERAAV--QERSTPKHCREDRVDRTEPEEPKANTGHKTVNRPPVKTLKSSNPGDDEFPVLGATALIPSVKPASVGGAATLKEEEYPSLSAAAVSAPMTPAYSAQPRKTSSFQ-------------EEDFPAL 461
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BLAST of RING-type domain-containing protein vs. Planmine SMEST
Match: SMESG000016211.1 (SMESG000016211.1)

HSP 1 Score: 1842.4 bits (4771), Expect = 0.000e+0
Identity = 895/902 (99.22%), Postives = 896/902 (99.33%), Query Frame = 3 
Query:   33 MSFSHSHFDCPVCGLTDKEIDFYGFSYCNHPICGVCSIKLQKFSKDVGNDYDYSKCVICKQDISKIILASSIKPFESFDQTNLLCDTQYDLLFESTKAESYYKNVIKIKCPKCKMPHNSMDDMILHMNDHKMRYCDLCVTFNKCLHYELEIYSDNDYHQHRYKKHPKCKFCETRFYDDSHLIKHVKDKHFVCDICHRNHGCVAYKTQIELLRHYSMDHFVCEICRSSNNINVFESEYNLKTHKVSVHSSSLVGEGLVTVGFGDNRDNQRYGNRRRQRDEDAFFVDSLPTAMEIPQVLPTFNCEQEFPRLGADAVASSQQLGVPSLTLDRNDARAAFIDQTETVMSEKETNKIQMTTAATSQANVGSSSNRHEKMSDNIAIMVKRSAGSLNSEDFPSLSSSLATGGNKPNMANGKSLKSVLQSSNRVPQTNPGVVEEDFPSLPACSGKSRPGQASKQSVWKPSGKSEPIKRDVVHSRDNVVSVTAVEERPKVSVMSNQEFQQAKIHPIRTHQPVPDAELDFPSLAGNGKPSSNLSTANWARPAPTSAPVAKQPFGNFAIESNSDFPGLSTTRCGNKHNSKSGFAKVASAAASIKQPTTASSVATHVNHASVTKAPLKSELQVVHEHVAPRTPMSLRGIDYIPSAPVKDPLIVLDSKQFSIMKQAKESSTGGVGSNFTLXXXXXXXXXXXXFPIMSNRYNGLSSTDTSVANGNKKSVNTGKVVPRFASESDFPTLAPSKSVAQKNKKPVVIKAVTEKPKPDSNKSRCPQQPVVSLMDVAMSVGQKSYTDLVDADQRNQNIFTLVTDSLNVDMATQFLQLANLYRTRKLSVHDYLDILQGDSFSGQMEFISRMLPEMCVLLPDIPLQRGLMSSMPKAWIKDLRQCTRCDQVLHKTDLALHNQKAH 2738
            MSFSHSHFDCPVCGLTDKEIDFYGFSYCNHPICGVCSIKLQKFSKDVGNDYDYSKCVICKQDISKIILASSIKPFESFDQTNLLCDTQYDLLFESTKAESYYKNVIKIKCPKCKMPHNSMDDMILHMNDHKMRYCDLCVTFNKCLHYELEIYSDNDYHQHRYKKHPKCKFCETRFYDDSHLIKHVKDKHFVCDICHRNHGCVAYKTQIELLRHYSMDHFVCEICRSSNNINVFESEYNLKTHKVSVHSSSLVGEGLVTVGFGDNRDNQRYGNRRRQRDEDAFFVDSLPTAMEIPQ LPTFNCEQEFPRLGADAVA SQQLGVPSLTLDRNDARAAFIDQTETVMSEKETNKIQMTTAATSQANVGSSSNRHEKMSDNIAIMVKRSAGSLNSEDFPSLSSSLATGGNKPNMANGKSLKSVLQSSNRVPQTNPGVVEEDFPSLPACSGKSRPGQASKQSVWKPSGKSEPIKRDVVHSRDNVV VTAVEERPKVSVMSNQEFQQAKI P+RTHQPVPDAELDFPSLAGNGKPSSNLSTANWAR APTSAPVAKQPFGNFAIESNSDFPGLSTTRCGNKHNSKSGFAKVASAAASIKQPTTASSVATHVNHASVTKAPLKSELQVVHEHVAPRTPMSLRGIDYIPSAPVKDPLIVLDSKQFSIMKQAKESSTGGVGSNFTLSEASGAQEAEEEFPIMSNRYNGLSS DTSVANGNKKSVNTGKVVPRFASESDFPTLAPSKSVAQKNKKPVVIKAVTEKPKPDSNKSRCPQQPVVSLMDVAMSVGQKSYTDLVDADQRNQNIFTLVTDSLNVDMATQFLQLANLYRTRKLSVHDYLDILQGDSFSGQMEFISRMLPEMCVLLPDIPLQRGLMSSMPKAWIKDLRQCTRCDQVLHKTDLALHNQKAH
Sbjct:    1 MSFSHSHFDCPVCGLTDKEIDFYGFSYCNHPICGVCSIKLQKFSKDVGNDYDYSKCVICKQDISKIILASSIKPFESFDQTNLLCDTQYDLLFESTKAESYYKNVIKIKCPKCKMPHNSMDDMILHMNDHKMRYCDLCVTFNKCLHYELEIYSDNDYHQHRYKKHPKCKFCETRFYDDSHLIKHVKDKHFVCDICHRNHGCVAYKTQIELLRHYSMDHFVCEICRSSNNINVFESEYNLKTHKVSVHSSSLVGEGLVTVGFGDNRDNQRYGNRRRQRDEDAFFVDSLPTAMEIPQALPTFNCEQEFPRLGADAVAGSQQLGVPSLTLDRNDARAAFIDQTETVMSEKETNKIQMTTAATSQANVGSSSNRHEKMSDNIAIMVKRSAGSLNSEDFPSLSSSLATGGNKPNMANGKSLKSVLQSSNRVPQTNPGVVEEDFPSLPACSGKSRPGQASKQSVWKPSGKSEPIKRDVVHSRDNVVRVTAVEERPKVSVMSNQEFQQAKIPPVRTHQPVPDAELDFPSLAGNGKPSSNLSTANWARAAPTSAPVAKQPFGNFAIESNSDFPGLSTTRCGNKHNSKSGFAKVASAAASIKQPTTASSVATHVNHASVTKAPLKSELQVVHEHVAPRTPMSLRGIDYIPSAPVKDPLIVLDSKQFSIMKQAKESSTGGVGSNFTLSEASGAQEAEEEFPIMSNRYNGLSSADTSVANGNKKSVNTGKVVPRFASESDFPTLAPSKSVAQKNKKPVVIKAVTEKPKPDSNKSRCPQQPVVSLMDVAMSVGQKSYTDLVDADQRNQNIFTLVTDSLNVDMATQFLQLANLYRTRKLSVHDYLDILQGDSFSGQMEFISRMLPEMCVLLPDIPLQRGLMSSMPKAWIKDLRQCTRCDQVLHKTDLALHNQKAH 902
The following BLAST results are available for this feature:
BLAST of RING-type domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 2
Match NameE-valueIdentityDescription
ZNF5981.689e-2926.59zinc finger protein 598 [Source:HGNC Symbol;Acc:HG... [more]
ZNF5984.558e-2627.75zinc finger protein 598 [Source:HGNC Symbol;Acc:HG... [more]
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BLAST of RING-type domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
C52E12.11.463e-2024.55pep chromosome:WBcel235:II:7025802:7030152:1 gene:... [more]
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BLAST of RING-type domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
CG114144.000e-3122.59gene:FBgn0035024 transcript:FBtr0072307[more]
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BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
znf5984.232e-3227.09zinc finger protein 598 [Source:NCBI gene;Acc:4077... [more]
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BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2
Match NameE-valueIdentityDescription
znf5981.422e-3130.68zinc finger protein 598 [Source:NCBI gene;Acc:7796... [more]
znf5989.905e-3029.88zinc finger protein 598 [Source:NCBI gene;Acc:7796... [more]
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BLAST of RING-type domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Zfp5982.319e-2927.38zinc finger protein 598 [Source:MGI Symbol;Acc:MGI... [more]
Zfp5982.434e-2927.38zinc finger protein 598 [Source:MGI Symbol;Acc:MGI... [more]
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BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q86UK7|ZN598_HUMAN9.313e-2926.59E3 ubiquitin-protein ligase ZNF598 OS=Homo sapiens... [more]
sp|Q80YR4|ZN598_MOUSE1.702e-2827.38E3 ubiquitin-protein ligase ZNF598 OS=Mus musculus... [more]
sp|Q6PFK1|ZN598_DANRE3.479e-2827.09E3 ubiquitin-protein ligase ZNF598 OS=Danio rerio ... [more]
sp|Q76PD2|HEL2_SCHPO2.651e-1926.20E3 ubiquitin-protein ligase hel2 OS=Schizosaccharo... [more]
sp|Q05580|HEL2_YEAST6.889e-1524.90E3 ubiquitin-protein ligase HEL2 OS=Saccharomyces ... [more]
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BLAST of RING-type domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A4S2MAB41.517e-4926.83RING-type domain-containing protein OS=Opisthorchi... [more]
A0A4S2MAD71.518e-4926.83RING-type domain-containing protein OS=Opisthorchi... [more]
A0A4E0RJ142.832e-4627.46Suppressor of SWI4 1 OS=Fasciola hepatica OX=6192 ... [more]
A0A5K4FFL76.325e-4527.67Uncharacterized protein OS=Schistosoma mansoni OX=... [more]
A0A4Z2DXC28.739e-4426.23E3 ubiquitin-protein isoform 1 OS=Schistosoma japo... [more]
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BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
znf5981.679e-2926.48zinc finger protein 598 [Source:NCBI gene;Acc:1030... [more]
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BLAST of RING-type domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of RING-type domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
HEL29.921e-1724.90RING finger ubiquitin ligase (E3); involved in ubi... [more]
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BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO400421.887e-2626.07Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of RING-type domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2
Match NameE-valueIdentityDescription
znf5983.729e-3022.57zinc finger protein 598 [Source:NCBI gene;Acc:1011... [more]
znf5983.685e-1521.82zinc finger protein 598 [Source:NCBI gene;Acc:1011... [more]
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BLAST of RING-type domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000016211.10.000e+099.22SMESG000016211.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30030902 ID=SMED30030902|Name=RING-type domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=2828bp
CGAATCCTTAATTTTATTTTATTTGACTTTACATGTCTTTTAGTCATTCT
CATTTTGATTGTCCTGTTTGTGGTCTAACAGATAAAGAAATTGACTTTTA
TGGGTTCAGTTATTGTAACCATCCAATTTGTGGAGTTTGTTCTATTAAAT
TGCAAAAATTTTCTAAGGATGTTGGCAATGACTATGATTATTCAAAATGT
GTAATTTGTAAACAAGATATTTCAAAGATTATTCTTGCATCTTCTATTAA
ACCTTTTGAATCATTCGATCAAACTAATTTATTATGTGATACTCAATATG
ATTTATTATTTGAATCTACTAAAGCTGAGTCATATTATAAAAATGTTATT
AAAATCAAATGCCCAAAATGTAAAATGCCTCACAATTCAATGGACGATAT
GATATTACATATGAATGATCATAAAATGAGATATTGTGATTTGTGTGTAA
CGTTTAATAAATGCCTTCATTATGAGCTTGAAATCTACTCTGATAATGAT
TATCATCAACATCGGTATAAGAAGCATCCGAAATGCAAGTTCTGTGAGAC
AAGGTTTTATGATGATTCTCATTTGATAAAACACGTGAAGGATAAGCATT
TCGTGTGTGATATTTGCCACCGAAACCATGGCTGCGTGGCATACAAAACC
CAGATCGAACTGTTGAGGCATTATTCCATGGATCATTTCGTTTGCGAAAT
CTGTCGCAGCAGTAACAATATCAACGTATTCGAGTCCGAATATAATTTGA
AAACTCACAAAGTTTCGGTCCATTCTTCGAGTTTGGTCGGGGAAGGCCTC
GTGACGGTTGGATTTGGGGATAACCGAGACAATCAGCGTTACGGAAATAG
GAGAAGACAACGTGACGAGGACGCATTTTTTGTCGATTCGTTACCGACGG
CCATGGAGATTCCCCAGGTGTTACCGACATTCAATTGTGAACAGGAGTTT
CCCCGATTAGGTGCTGATGCGGTCGCTAGCAGTCAGCAGTTGGGTGTCCC
GTCACTCACTCTCGACCGCAACGATGCCAGAGCGGCCTTTATCGACCAGA
CCGAAACAGTGATGAGTGAAAAAGAAACAAACAAGATACAAATGACGACA
GCAGCGACATCGCAGGCAAATGTCGGAAGCAGTAGCAATAGGCATGAGAA
AATGTCGGATAATATCGCAATAATGGTGAAGCGATCTGCAGGCAGCCTCA
ATTCCGAGGATTTCCCCTCGCTCTCATCGTCATTGGCAACCGGTGGTAAT
AAACCAAATATGGCAAACGGCAAATCATTGAAATCGGTGCTGCAGTCATC
CAATCGAGTGCCGCAAACGAATCCAGGTGTTGTAGAGGAGGATTTCCCGT
CACTGCCGGCCTGTTCGGGTAAATCGCGACCGGGACAAGCGAGTAAGCAA
TCGGTATGGAAACCCTCGGGTAAATCGGAACCTATAAAGAGGGACGTCGT
GCATTCCCGTGATAACGTTGTCAGTGTAACTGCAGTAGAGGAGCGCCCAA
AGGTATCCGTGATGAGCAATCAGGAATTCCAGCAGGCAAAGATCCACCCA
ATTAGAACGCATCAGCCTGTGCCGGACGCAGAACTCGATTTTCCCAGCTT
GGCAGGTAACGGGAAGCCTTCATCCAATCTATCAACAGCGAACTGGGCGA
GACCGGCGCCCACATCTGCACCGGTAGCCAAGCAACCGTTTGGTAACTTT
GCCATTGAAAGCAATTCAGATTTCCCAGGATTGTCTACAACTCGCTGTGG
CAACAAGCATAATTCCAAGTCAGGATTTGCCAAGGTTGCCAGTGCTGCTG
CATCAATCAAGCAGCCTACGACCGCTTCATCCGTTGCCACGCACGTCAAT
CACGCCTCCGTTACTAAGGCGCCACTCAAATCAGAGCTGCAAGTCGTGCA
CGAGCATGTGGCACCAAGGACTCCTATGTCCCTTCGGGGCATAGATTACA
TTCCGTCGGCACCCGTGAAAGATCCTCTGATTGTTTTGGATTCCAAGCAG
TTCTCAATTATGAAGCAGGCCAAGGAGTCGTCGACAGGTGGTGTAGGGTC
TAATTTCACCCTGTCGGAGGCCAGTGGTGCTCAAGAGGCAGAGGAGGAGT
TTCCAATCATGTCAAACCGATATAACGGTCTTTCTAGCACTGATACGTCT
GTAGCCAATGGAAACAAGAAATCTGTTAACACTGGCAAAGTTGTGCCTCG
ATTCGCGTCGGAATCAGATTTCCCAACTCTGGCGCCAAGTAAGTCAGTGG
CTCAGAAAAATAAAAAACCGGTCGTAATCAAAGCAGTAACCGAGAAACCG
AAACCCGATAGTAACAAGTCACGGTGTCCACAGCAACCGGTTGTCAGCTT
GATGGATGTTGCCATGAGTGTTGGTCAGAAGTCGTATACGGATCTCGTGG
ATGCCGACCAGCGAAATCAGAATATTTTCACGCTAGTCACAGACAGTCTC
AATGTTGACATGGCAACTCAATTCCTGCAGTTAGCCAATCTGTATCGCAC
GAGGAAGCTATCAGTCCATGATTATCTCGATATATTGCAAGGAGATTCAT
TTAGTGGCCAGATGGAGTTTATATCACGGATGCTGCCGGAAATGTGTGTG
TTACTGCCGGACATCCCGTTGCAGCGTGGCCTAATGAGCAGCATGCCAAA
GGCGTGGATTAAGGACCTCCGGCAATGCACTAGGTGCGACCAAGTCCTCC
ACAAGACAGATCTGGCTCTCCATAACCAGAAGGCTCACTAATTATATAAT
TTTCCGGCCCGACTTATTCAGATTTTCCTTCATTCATTCGGTTGATTTTT
CCTGAGGTTTTGCAATGAAATATATTTT
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protein sequence of SMED30030902-orf-1

>SMED30030902-orf-1 ID=SMED30030902-orf-1|Name=SMED30030902-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=903bp
MSFSHSHFDCPVCGLTDKEIDFYGFSYCNHPICGVCSIKLQKFSKDVGND
YDYSKCVICKQDISKIILASSIKPFESFDQTNLLCDTQYDLLFESTKAES
YYKNVIKIKCPKCKMPHNSMDDMILHMNDHKMRYCDLCVTFNKCLHYELE
IYSDNDYHQHRYKKHPKCKFCETRFYDDSHLIKHVKDKHFVCDICHRNHG
CVAYKTQIELLRHYSMDHFVCEICRSSNNINVFESEYNLKTHKVSVHSSS
LVGEGLVTVGFGDNRDNQRYGNRRRQRDEDAFFVDSLPTAMEIPQVLPTF
NCEQEFPRLGADAVASSQQLGVPSLTLDRNDARAAFIDQTETVMSEKETN
KIQMTTAATSQANVGSSSNRHEKMSDNIAIMVKRSAGSLNSEDFPSLSSS
LATGGNKPNMANGKSLKSVLQSSNRVPQTNPGVVEEDFPSLPACSGKSRP
GQASKQSVWKPSGKSEPIKRDVVHSRDNVVSVTAVEERPKVSVMSNQEFQ
QAKIHPIRTHQPVPDAELDFPSLAGNGKPSSNLSTANWARPAPTSAPVAK
QPFGNFAIESNSDFPGLSTTRCGNKHNSKSGFAKVASAAASIKQPTTASS
VATHVNHASVTKAPLKSELQVVHEHVAPRTPMSLRGIDYIPSAPVKDPLI
VLDSKQFSIMKQAKESSTGGVGSNFTLSEASGAQEAEEEFPIMSNRYNGL
SSTDTSVANGNKKSVNTGKVVPRFASESDFPTLAPSKSVAQKNKKPVVIK
AVTEKPKPDSNKSRCPQQPVVSLMDVAMSVGQKSYTDLVDADQRNQNIFT
LVTDSLNVDMATQFLQLANLYRTRKLSVHDYLDILQGDSFSGQMEFISRM
LPEMCVLLPDIPLQRGLMSSMPKAWIKDLRQCTRCDQVLHKTDLALHNQK
AH*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0003676nucleic acid binding
GO:0046872metal ion binding
GO:0008233peptidase activity
GO:0008270zinc ion binding
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002111X2 cell
Vocabulary: INTERPRO
TermDefinition
IPR013087Znf_C2H2_type
IPR015880Znf_C2H2-like
IPR007087Znf_C2H2
IPR006928htUSP
Vocabulary: biological process
TermDefinition
GO:0006508proteolysis
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR013087Zinc finger C2H2-typeSMARTSM00355c2h2final6coord: 219..247
e-value: 5.6
score: 15.5
coord: 108..130
e-value: 0.99
score: 18.4
coord: 166..189
e-value: 0.46
score: 19.5
coord: 880..902
e-value: 110.0
score: 4.1
coord: 190..218
e-value: 22.0
score: 10.3
IPR013087Zinc finger C2H2-typePROSITEPS00028ZINC_FINGER_C2H2_1coord: 168..189
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 442..467
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 447..461
NoneNo IPR availablePANTHERPTHR22938:SF0E3 UBIQUITIN-PROTEIN LIGASE ZNF598coord: 12..871
NoneNo IPR availablePANTHERPTHR22938ZINC FINGER PROTEIN 598coord: 12..871