RING-CH-type domain-containing protein

Overview


Name	RING-CH-type domain-containing protein
Smed ID	SMED30030835
Length (bp)	1916

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of RING-CH-type domain-containing protein (SMED30030835) t-SNE clustered cells

Violin plots show distribution of expression levels for RING-CH-type domain-containing protein (SMED30030835) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of RING-CH-type domain-containing protein (SMED30030835) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for RING-CH-type domain-containing protein (SMED30030835) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30030835

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 4

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
gut	SMED30030835	h1SMcG0001066	dd_Smed_v4_4997_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30030835	h1SMcG0001066	dd_Smed_v4_4997_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017
ovary	SMED30030835	h1SMcG0001066	SMED30030835	smed_20140614	PMID:279364
testis	SMED30030835	h1SMcG0001066	SMED30030835	smed_20140614	PMID:279364

Note: Hover over icons to view figure legend

Homology

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BLAST of RING-CH-type domain-containing protein vs. Ensembl Human
Match: MARCHF1 (membrane associated ring-CH-type finger 1 [Source:HGNC Symbol;Acc:HGNC:26077])

HSP 1 Score: 204.527 bits (519), Expect = 2.555e-60
Identity = 105/171 (61.40%), Postives = 131/171 (76.61%), Query Frame = 1

Query:  475 LSITSSNEVFCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIH----NGIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQN 972
            LS+  S +  CR C  E + ES L+TPC C+GTL+F+HQSCL +WIK  D R CELCKY+F M+   KPLR+W+KL+M+  E+RKI CSVTFH+IA+TCV+WSLYVLI+RT EEI     NG++EWP WTKL+VVAIGF GG+VFMYVQC++YV L R+   YNR   VQN
Sbjct:   70 LSVCPSTQDICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELCKYDFIMETKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGNDNGVLEWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQN 240

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Query:  475 LSITSSNEVFCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIH----NGIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQN 972
            LS+  S +  CR C  E + ES L+TPC C+GTL+F+HQSCL +WIK  D R CELCKY+F M+   KPLR+W+KL+M+  E+RKI CSVTFH+IA+TCV+WSLYVLI+RT EEI     NG++EWP WTKL+VVAIGF GG+VFMYVQC++YV L R+   YNR   VQN
Sbjct:   70 LSVCPSTQDICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELCKYDFIMETKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGNDNGVLEWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQN 240

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BLAST of RING-CH-type domain-containing protein vs. Ensembl Human
Match: MARCHF1 (membrane associated ring-CH-type finger 1 [Source:HGNC Symbol;Acc:HGNC:26077])

HSP 1 Score: 202.601 bits (514), Expect = 8.151e-60
Identity = 105/171 (61.40%), Postives = 131/171 (76.61%), Query Frame = 1

Query:  475 LSITSSNEVFCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIH----NGIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQN 972
            LS+  S +  CR C  E + ES L+TPC C+GTL+F+HQSCL +WIK  D R CELCKY+F M+   KPLR+W+KL+M+  E+RKI CSVTFH+IA+TCV+WSLYVLI+RT EEI     NG++EWP WTKL+VVAIGF GG+VFMYVQC++YV L R+   YNR   VQN
Sbjct:   53 LSVCPSTQDICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELCKYDFIMETKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGNDNGVLEWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQN 223

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BLAST of RING-CH-type domain-containing protein vs. Ensembl Human
Match: MARCHF8 (membrane associated ring-CH-type finger 8 [Source:HGNC Symbol;Acc:HGNC:23356])

HSP 1 Score: 199.519 bits (506), Expect = 2.330e-58
Identity = 104/170 (61.18%), Postives = 132/170 (77.65%), Query Frame = 1

Query:  478 SITSSNEVFCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIH----NGIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQN 972
            SIT S++  CR C  E + ES L+TPC C+G+L F+HQ+CLQ+WIK  D R CELCKYEF M+   KPLR+W+KL+M+  E+RKI+CSVTFH+IA+TCV+WSLYVLI+RT EEI      GI+EWP WTKL+VVAIGF GG++FMYVQC++YV L ++   YNR   VQN
Sbjct:   71 SITPSSQDICRICHCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDTRCCELCKYEFIMETKLKPLRKWEKLQMTSSERRKIMCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGQATGILEWPFWTKLVVVAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQN 240

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Query:  478 SITSSNEVFCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIH----NGIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQN 972
            SIT S++  CR C  E + ES L+TPC C+G+L F+HQ+CLQ+WIK  D R CELCKYEF M+   KPLR+W+KL+M+  E+RKI+CSVTFH+IA+TCV+WSLYVLI+RT EEI      GI+EWP WTKL+VVAIGF GG++FMYVQC++YV L ++   YNR   VQN
Sbjct:   71 SITPSSQDICRICHCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDTRCCELCKYEFIMETKLKPLRKWEKLQMTSSERRKIMCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGQATGILEWPFWTKLVVVAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQN 240

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BLAST of RING-CH-type domain-containing protein vs. Ensembl Celegans
Match: marc-1 (MARCH (Membrane-Associated Ring finger (C3HC4)) homolog [Source:UniProtKB/TrEMBL;Acc:B2D6L6])

HSP 1 Score: 63.5438 bits (153), Expect = 2.826e-11
Identity = 28/79 (35.44%), Postives = 48/79 (60.76%), Query Frame = 1

Query:  478 SITSSNEVFCRFCQEYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITS-KPLREWQKLEMSI 711
            S TS +   CR CQ +E   ++V PC C+GT+  +H+ CL +W+ + + + CE+CK E+       KP+++W K + S+
Sbjct:   43 STTSGSRRICRICQMHE--GDMVRPCDCAGTMGDVHEECLTKWVNMSNKKTCEICKSEYTNSGAQFKPIKQWSKPKCSL 119

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BLAST of RING-CH-type domain-containing protein vs. Ensembl Celegans
Match: marc-2 (MARCH (Membrane-Associated Ring finger (C3HC4)) homolog [Source:UniProtKB/TrEMBL;Acc:Q18997])

HSP 1 Score: 56.225 bits (134), Expect = 1.025e-8
Identity = 24/74 (32.43%), Postives = 44/74 (59.46%), Query Frame = 1

Query:  487 SSNEVFCRFCQEYEPESE-LVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEM 705
            S+  V CR C + +  S+ L+ PC CSGT+ ++H  CL++W++   N  C +C+  F  ++    L++W K+ +
Sbjct:   19 STKTVICRICFDNDTSSDSLIKPCSCSGTVAYVHNGCLEQWVRTTSNIQCTICQDMF--ELIPAGLKDWNKITL 90

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BLAST of RING-CH-type domain-containing protein vs. Ensembl Celegans
Match: marc-3 (MARCH (Membrane-Associated Ring finger (C3HC4)) homolog [Source:UniProtKB/TrEMBL;Acc:Q93227])

HSP 1 Score: 57.7658 bits (138), Expect = 1.598e-8
Identity = 27/96 (28.12%), Postives = 49/96 (51.04%), Query Frame = 1

Query:  517 QEYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREW--QKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIE 798
            Q  EP   L++PC CSGT+   H+SCL+ W+ +     CE+CK+ F++K  S+   ++  Q     +   R       F ++ L    + +++ +E
Sbjct:   29 QAGEP---LISPCKCSGTMGLFHRSCLEHWLTLTSTTNCEICKFAFKIKQKSRNFIDYIRQGGYKKLQSNRNPFIDFAFVLLILPFAFFGVFMSVE 121

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BLAST of RING-CH-type domain-containing protein vs. Ensembl Celegans
Match: marc-5 (MARCH (Membrane-Associated Ring finger (C3HC4)) homolog [Source:UniProtKB/TrEMBL;Acc:Q9XWI0])

HSP 1 Score: 57.3806 bits (137), Expect = 1.947e-8
Identity = 26/66 (39.39%), Postives = 40/66 (60.61%), Query Frame = 1

Query:  490 SNEVFCRFCQE-YEPESE--LVTPCLCSGTLKFIHQSCLQRWIKVQDNRF-----CELCKYEFRMK 663
            SNE  CR C   + P+S   L++PC CSG+L+++H SCL  W+ +   +      CELC Y++R +
Sbjct:  189 SNEPLCRICHCCWPPDSNDPLISPCRCSGSLQYVHVSCLMHWLDISSRKLHRPAICELCLYKYRRR 254

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BLAST of RING-CH-type domain-containing protein vs. Ensembl Celegans
Match: marc-4 (MARCH (Membrane-Associated Ring finger (C3HC4)) homolog [Source:UniProtKB/TrEMBL;Acc:Q9N5V7])

HSP 1 Score: 56.225 bits (134), Expect = 2.979e-8
Identity = 25/68 (36.76%), Postives = 41/68 (60.29%), Query Frame = 1

Query:  475 LSITSSNEVFCRFCQEYEP--ESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRF-----CELCKYEFR 657
            LS+ S++   CR C        + L++PC CSGTL F+H++C+ RW+++   +      CELC Y++R
Sbjct:   70 LSLQSASANMCRICHTSTSTRSNPLISPCRCSGTLLFVHKACVVRWLEMSTRKMVPSPRCELCGYDYR 137

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BLAST of RING-CH-type domain-containing protein vs. Ensembl Fly
Match: CG4080 (gene:FBgn0035983 transcript:FBtr0309506)

HSP 1 Score: 177.563 bits (449), Expect = 1.271e-47
Identity = 88/201 (43.78%), Postives = 123/201 (61.19%), Query Frame = 1

Query:  445 NSEQSNCNVNLSITSSNEV-----FCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIHNGIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQN-------ITPMELVAAQKE 1008
            NS Q   NV     SS         CR C  E +P++ L+TPC CSG+LK++HQ+CLQ+W+   +   CELCK+ F M    KP  EW+ L++S +E+R++  SV FH  A  CVIWSL VLIER  +++  G+++WP WTKL VV +G  GG+VFMY+QC+ Y+ LC +W   NR  ++QN       + P   VAA  +
Sbjct:   18 NSGQHYANVRFGSGSSQASQNSGDICRICHCESDPQNPLLTPCYCSGSLKYVHQACLQQWLTASETNSCELCKFPFIMHTKIKPFNEWRSLDISGIERRRLCYSVLFHCAAALCVIWSLCVLIERAADDVQRGLIDWPFWTKLAVVTVGLTGGIVFMYIQCKAYLHLCHRWKARNRILLIQNAPEKIHPVAPPSPVAAHHQ 218

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BLAST of RING-CH-type domain-containing protein vs. Ensembl Fly
Match: CG4080 (gene:FBgn0035983 transcript:FBtr0076494)

HSP 1 Score: 177.563 bits (449), Expect = 1.271e-47
Identity = 88/201 (43.78%), Postives = 123/201 (61.19%), Query Frame = 1

Query:  445 NSEQSNCNVNLSITSSNEV-----FCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIHNGIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQN-------ITPMELVAAQKE 1008
            NS Q   NV     SS         CR C  E +P++ L+TPC CSG+LK++HQ+CLQ+W+   +   CELCK+ F M    KP  EW+ L++S +E+R++  SV FH  A  CVIWSL VLIER  +++  G+++WP WTKL VV +G  GG+VFMY+QC+ Y+ LC +W   NR  ++QN       + P   VAA  +
Sbjct:   18 NSGQHYANVRFGSGSSQASQNSGDICRICHCESDPQNPLLTPCYCSGSLKYVHQACLQQWLTASETNSCELCKFPFIMHTKIKPFNEWRSLDISGIERRRLCYSVLFHCAAALCVIWSLCVLIERAADDVQRGLIDWPFWTKLAVVTVGLTGGIVFMYIQCKAYLHLCHRWKARNRILLIQNAPEKIHPVAPPSPVAAHHQ 218

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BLAST of RING-CH-type domain-containing protein vs. Ensembl Fly
Match: CG13442 (gene:FBgn0034546 transcript:FBtr0086240)

HSP 1 Score: 65.0846 bits (157), Expect = 8.026e-11
Identity = 44/149 (29.53%), Postives = 72/149 (48.32%), Query Frame = 1

Query:  424 ANQIDNSNSEQSNCNVNLSITSSNEVFCRFCQEYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSK-----PLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIHN-GIMEWPLWTK 852
            A Q +N N E ++   N S+ S   + CR C   +   +LV+PCLC G+L ++H  CL+ WI       CELC++++  + T +      LR W    MS    ++     +   +    +I +L V I+      H+ G+ +  LWTK
Sbjct:  143 ATQCNNLNYESAS---NESMPSVGSLVCRICHNADNPEQLVSPCLCKGSLTYVHVHCLECWISTSRCTTCELCQFQYNTEQTLRYTCLQSLRLWYSRAMSRRALQEDCQMFSLLTLVAFGIIGTLLVGIQYYALHTHSWGLSK--LWTK 286

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BLAST of RING-CH-type domain-containing protein vs. Ensembl Fly
Match: CG1317 (gene:FBgn0035333 transcript:FBtr0300773)

HSP 1 Score: 63.929 bits (154), Expect = 3.898e-10
Identity = 24/59 (40.68%), Postives = 36/59 (61.02%), Query Frame = 1

Query:  505 CRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKP 678
            CR C+ E +P+  L  PC+C+G++K+IHQ CL  W++     +CELC Y F  +    P
Sbjct:   10 CRVCRCEAQPDRPLFYPCICTGSIKYIHQDCLMLWMRYSHKEYCELCSYSFSFQPIYAP 68

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BLAST of RING-CH-type domain-containing protein vs. Ensembl Fly
Match: CG1317 (gene:FBgn0035333 transcript:FBtr0072901)

HSP 1 Score: 63.929 bits (154), Expect = 3.898e-10
Identity = 24/59 (40.68%), Postives = 36/59 (61.02%), Query Frame = 1

Query:  505 CRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKP 678
            CR C+ E +P+  L  PC+C+G++K+IHQ CL  W++     +CELC Y F  +    P
Sbjct:   10 CRVCRCEAQPDRPLFYPCICTGSIKYIHQDCLMLWMRYSHKEYCELCSYSFSFQPIYAP 68

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BLAST of RING-CH-type domain-containing protein vs. Ensembl Zebrafish
Match: march8 (membrane-associated ring finger (C3HC4) 8 [Source:ZFIN;Acc:ZDB-GENE-080204-8])

HSP 1 Score: 209.149 bits (531), Expect = 2.323e-62
Identity = 104/166 (62.65%), Postives = 133/166 (80.12%), Query Frame = 1

Query:  478 SITSSNEVFCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIHNGIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQN 972
            S+T SN+  CR C  E + ES L+TPC C+G+L+F+HQ+CLQ+WIK  D R CELCKY+F M+   KPLR+W+KL+M+  E+RKI+CSVTFH+IA+TCV+WSLYVLI+RT EEI  GI+EWP WTKL+VVAIGF GG+VFMYVQC++Y+ L R+   YNR   VQN
Sbjct:   66 SVTPSNQDICRICHCEGDDESPLITPCHCTGSLRFVHQACLQQWIKSSDTRCCELCKYDFIMETKLKPLRKWEKLQMTASERRKIMCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGILEWPFWTKLVVVAIGFTGGLVFMYVQCKVYIQLWRRLKAYNRVIYVQN 231

[Close]

BLAST of RING-CH-type domain-containing protein vs. Ensembl Zebrafish
Match: march8 (membrane-associated ring finger (C3HC4) 8 [Source:ZFIN;Acc:ZDB-GENE-080204-8])

HSP 1 Score: 195.667 bits (496), Expect = 3.045e-54
Identity = 108/202 (53.47%), Postives = 137/202 (67.82%), Query Frame = 1

Query:  433 IDNSNSEQSNCNVNLSITSSNEVFCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEI------------HNG---------IMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQN 972
            +D   S  S  N  LS  S +   CR C  E + ES L+TPC C+G+L+F+HQ+CLQ+WIK  D R CELCKY+F M+   KPLR+W+KL+M+  E+RKI+CSVTFH+IA+TCV+WSLYVLI+RT EEI            H G         I+EWP WTKL+VVAIGF GG+VFMYVQC++Y+ L R+   YNR   VQN
Sbjct:  328 LDQCTSPLSEKNAPLSPYSLSGDCCRICHCEGDDESPLITPCHCTGSLRFVHQACLQQWIKSSDTRCCELCKYDFIMETKLKPLRKWEKLQMTASERRKIMCSVTFHVIAITCVVWSLYVLIDRTAEEIKQAGRIPGGLKLHPGLAYGGSESRILEWPFWTKLVVVAIGFTGGLVFMYVQCKVYIQLWRRLKAYNRVIYVQN 529

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BLAST of RING-CH-type domain-containing protein vs. Ensembl Zebrafish
Match: march1 (membrane-associated ring finger (C3HC4) 1 [Source:ZFIN;Acc:ZDB-GENE-081112-1])

HSP 1 Score: 184.111 bits (466), Expect = 7.563e-53
Identity = 95/181 (52.49%), Postives = 126/181 (69.61%), Query Frame = 1

Query:  478 SITSSNEVFCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIHN---------------GIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQN 972
            S+T S++  CR C  E + E  L+TPC C+G+L+F+HQ CL +WIK  D R CELCKY+F M+   KPLR+W+KL MS  E+RKI CSV FH+ A+ CVIWSLYVLI+RT EEI +               G+++WP WTKLIVVA+GF GG++FMY+QC++Y+ L R+   +NR   VQN
Sbjct:   65 SVTHSSQDICRICHCEGDEECPLITPCHCTGSLRFVHQGCLHQWIKSSDTRCCELCKYDFIMETHLKPLRKWEKLHMSTSERRKIFCSVIFHLAAVVCVIWSLYVLIDRTAEEIRHSKNKALVRLSPLNAVGVLDWPFWTKLIVVAVGFTGGLIFMYIQCKVYLQLWRRLKAFNRIIFVQN 245

[Close]

BLAST of RING-CH-type domain-containing protein vs. Ensembl Zebrafish
Match: march1 (membrane-associated ring finger (C3HC4) 1 [Source:ZFIN;Acc:ZDB-GENE-081112-1])

HSP 1 Score: 181.415 bits (459), Expect = 1.415e-49
Identity = 92/173 (53.18%), Postives = 120/173 (69.36%), Query Frame = 1

Query:  502 FCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIHN---------------GIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQN 972
             CR C  E + E  L+TPC C+G+L+F+HQ CL +WIK  D R CELCKY+F M+   KPLR+W+KL MS  E+RKI CSV FH+ A+ CVIWSLYVLI+RT EEI +               G+++WP WTKLIVVA+GF GG++FMY+QC++Y+ L R+   +NR   VQN
Sbjct:  287 VCRICHCEGDEECPLITPCHCTGSLRFVHQGCLHQWIKSSDTRCCELCKYDFIMETHLKPLRKWEKLHMSTSERRKIFCSVIFHLAAVVCVIWSLYVLIDRTAEEIRHSKNKALVRLSPLNAVGVLDWPFWTKLIVVAVGFTGGLIFMYIQCKVYLQLWRRLKAFNRIIFVQN 459

[Close]

BLAST of RING-CH-type domain-containing protein vs. Ensembl Zebrafish
Match: march1 (membrane-associated ring finger (C3HC4) 1 [Source:ZFIN;Acc:ZDB-GENE-081112-1])

HSP 1 Score: 181.415 bits (459), Expect = 1.415e-49
Identity = 92/173 (53.18%), Postives = 120/173 (69.36%), Query Frame = 1

Query:  502 FCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIHN---------------GIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQN 972
             CR C  E + E  L+TPC C+G+L+F+HQ CL +WIK  D R CELCKY+F M+   KPLR+W+KL MS  E+RKI CSV FH+ A+ CVIWSLYVLI+RT EEI +               G+++WP WTKLIVVA+GF GG++FMY+QC++Y+ L R+   +NR   VQN
Sbjct:  287 VCRICHCEGDEECPLITPCHCTGSLRFVHQGCLHQWIKSSDTRCCELCKYDFIMETHLKPLRKWEKLHMSTSERRKIFCSVIFHLAAVVCVIWSLYVLIDRTAEEIRHSKNKALVRLSPLNAVGVLDWPFWTKLIVVAVGFTGGLIFMYIQCKVYLQLWRRLKAFNRIIFVQN 459

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BLAST of RING-CH-type domain-containing protein vs. Ensembl Xenopus
Match: faf1 (Fas (TNFRSF6) associated factor 1 [Source:Xenbase;Acc:XB-GENE-940895])

HSP 1 Score: 200.675 bits (509), Expect = 3.506e-59
Identity = 103/170 (60.59%), Postives = 134/170 (78.82%), Query Frame = 1

Query:  478 SITSSNEVFCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEI----HNGIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQN 972
            S+T S++  CR C  E + ES L+TPC C+G+L F+HQ+CLQ+WIK  D R CELCK+EF M+   KPLR+W+KL+M+  E+RKI+CSVTFH+IA+TCV+WSLYVLI+RT EEI    +NGI+EWP WTKL+VVAIGF GG++FMYVQC++YV L ++   YNR   VQN
Sbjct:   48 SVTPSSQDICRICHCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDTRCCELCKFEFIMETKLKPLRKWEKLQMTASERRKIMCSVTFHVIAITCVVWSLYVLIDRTAEEIKMGQNNGILEWPFWTKLVVVAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQN 217

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BLAST of RING-CH-type domain-containing protein vs. Ensembl Xenopus
Match: faf1 (Fas (TNFRSF6) associated factor 1 [Source:Xenbase;Acc:XB-GENE-940895])

HSP 1 Score: 199.904 bits (507), Expect = 7.208e-59
Identity = 103/170 (60.59%), Postives = 134/170 (78.82%), Query Frame = 1

Query:  478 SITSSNEVFCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEI----HNGIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQN 972
            S+T S++  CR C  E + ES L+TPC C+G+L F+HQ+CLQ+WIK  D R CELCK+EF M+   KPLR+W+KL+M+  E+RKI+CSVTFH+IA+TCV+WSLYVLI+RT EEI    +NGI+EWP WTKL+VVAIGF GG++FMYVQC++YV L ++   YNR   VQN
Sbjct:   46 SVTPSSQDICRICHCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDTRCCELCKFEFIMETKLKPLRKWEKLQMTASERRKIMCSVTFHVIAITCVVWSLYVLIDRTAEEIKMGQNNGILEWPFWTKLVVVAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQN 215

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BLAST of RING-CH-type domain-containing protein vs. Ensembl Xenopus
Match: faf1 (Fas (TNFRSF6) associated factor 1 [Source:Xenbase;Acc:XB-GENE-940895])

HSP 1 Score: 201.445 bits (511), Expect = 8.269e-59
Identity = 103/170 (60.59%), Postives = 134/170 (78.82%), Query Frame = 1

Query:  478 SITSSNEVFCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEI----HNGIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQN 972
            S+T S++  CR C  E + ES L+TPC C+G+L F+HQ+CLQ+WIK  D R CELCK+EF M+   KPLR+W+KL+M+  E+RKI+CSVTFH+IA+TCV+WSLYVLI+RT EEI    +NGI+EWP WTKL+VVAIGF GG++FMYVQC++YV L ++   YNR   VQN
Sbjct:   91 SVTPSSQDICRICHCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDTRCCELCKFEFIMETKLKPLRKWEKLQMTASERRKIMCSVTFHVIAITCVVWSLYVLIDRTAEEIKMGQNNGILEWPFWTKLVVVAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQN 260

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BLAST of RING-CH-type domain-containing protein vs. Ensembl Xenopus
Match: faf1 (Fas (TNFRSF6) associated factor 1 [Source:Xenbase;Acc:XB-GENE-940895])

HSP 1 Score: 201.83 bits (512), Expect = 9.122e-59
Identity = 103/170 (60.59%), Postives = 134/170 (78.82%), Query Frame = 1

Query:  478 SITSSNEVFCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEI----HNGIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQN 972
            S+T S++  CR C  E + ES L+TPC C+G+L F+HQ+CLQ+WIK  D R CELCK+EF M+   KPLR+W+KL+M+  E+RKI+CSVTFH+IA+TCV+WSLYVLI+RT EEI    +NGI+EWP WTKL+VVAIGF GG++FMYVQC++YV L ++   YNR   VQN
Sbjct:  108 SVTPSSQDICRICHCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDTRCCELCKFEFIMETKLKPLRKWEKLQMTASERRKIMCSVTFHVIAITCVVWSLYVLIDRTAEEIKMGQNNGILEWPFWTKLVVVAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQN 277

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BLAST of RING-CH-type domain-containing protein vs. Ensembl Xenopus
Match: ube2a (ubiquitin conjugating enzyme E2 A [Source:Xenbase;Acc:XB-GENE-969236])

HSP 1 Score: 200.675 bits (509), Expect = 8.764e-57
Identity = 104/173 (60.12%), Postives = 132/173 (76.30%), Query Frame = 1

Query:  469 VNLSITSSNEVFCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEI----HNGIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQN 972
            VN +  S +   CR C  E + E+ L+TPCLC+GTL+F+HQ+CL +WIK  D R CELCKY+F M+   KPLR+W+KL+M+  E+ KIICSVTFHIIALTCV+WSLYVLI+RT EEI     NG++EWP WTKL+VVAIGF GG++FMYVQC++Y+ L R+   YNR   VQN
Sbjct:  253 VNSNDVSEDLDVCRICHCEGDEENPLITPCLCTGTLRFVHQTCLHQWIKSSDTRCCELCKYDFVMETKLKPLRKWEKLQMTKSERSKIICSVTFHIIALTCVMWSLYVLIDRTAEEIKQGSENGVLEWPFWTKLVVVAIGFTGGLIFMYVQCKVYIQLWRRLKAYNRVIFVQN 425

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BLAST of RING-CH-type domain-containing protein vs. Ensembl Mouse
Match: March1 (membrane-associated ring finger (C3HC4) 1 [Source:MGI Symbol;Acc:MGI:1920175])

HSP 1 Score: 207.223 bits (526), Expect = 1.459e-61
Identity = 104/167 (62.28%), Postives = 130/167 (77.84%), Query Frame = 1

Query:  475 LSITSSNEVFCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIHNGIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQN 972
            LS+  S +  CR C  E + ES L+TPC C+GTL+F+HQSCL +WIK  D R CELCKY+F M+   KPLR+W+KL+M+  E+RKI CSVTFH+IA+TCV+WSLYVLI+RT EEI  G++EWP WTKL+VVAIGF GG+VFMYVQC++YV L R+   YNR   VQN
Sbjct:   70 LSVCPSTQDICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELCKYDFIMETKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAVTCVVWSLYVLIDRTAEEIKQGVLEWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQN 236

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Query:  475 LSITSSNEVFCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIHNGIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQN 972
            LS+  S +  CR C  E + ES L+TPC C+GTL+F+HQSCL +WIK  D R CELCKY+F M+   KPLR+W+KL+M+  E+RKI CSVTFH+IA+TCV+WSLYVLI+RT EEI  G++EWP WTKL+VVAIGF GG+VFMYVQC++YV L R+   YNR   VQN
Sbjct:   70 LSVCPSTQDICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELCKYDFIMETKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAVTCVVWSLYVLIDRTAEEIKQGVLEWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQN 236

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BLAST of RING-CH-type domain-containing protein vs. Ensembl Mouse
Match: March1 (membrane-associated ring finger (C3HC4) 1 [Source:MGI Symbol;Acc:MGI:1920175])

HSP 1 Score: 205.682 bits (522), Expect = 5.336e-61
Identity = 104/167 (62.28%), Postives = 130/167 (77.84%), Query Frame = 1

Query:  475 LSITSSNEVFCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIHNGIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQN 972
            LS+  S +  CR C  E + ES L+TPC C+GTL+F+HQSCL +WIK  D R CELCKY+F M+   KPLR+W+KL+M+  E+RKI CSVTFH+IA+TCV+WSLYVLI+RT EEI  G++EWP WTKL+VVAIGF GG+VFMYVQC++YV L R+   YNR   VQN
Sbjct:   60 LSVCPSTQDICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELCKYDFIMETKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAVTCVVWSLYVLIDRTAEEIKQGVLEWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQN 226

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BLAST of RING-CH-type domain-containing protein vs. Ensembl Mouse
Match: March1 (membrane-associated ring finger (C3HC4) 1 [Source:MGI Symbol;Acc:MGI:1920175])

HSP 1 Score: 204.527 bits (519), Expect = 1.980e-60
Identity = 105/171 (61.40%), Postives = 131/171 (76.61%), Query Frame = 1

Query:  475 LSITSSNEVFCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIH----NGIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQN 972
            LS+  S +  CR C  E + ES L+TPC C+GTL+F+HQSCL +WIK  D R CELCKY+F M+   KPLR+W+KL+M+  E+RKI CSVTFH+IA+TCV+WSLYVLI+RT EEI     NG++EWP WTKL+VVAIGF GG+VFMYVQC++YV L R+   YNR   VQN
Sbjct:   66 LSVCPSTQDICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELCKYDFIMETKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAVTCVVWSLYVLIDRTAEEIKQGNDNGVLEWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQN 236

[Close]

BLAST of RING-CH-type domain-containing protein vs. Ensembl Mouse
Match: March1 (membrane-associated ring finger (C3HC4) 1 [Source:MGI Symbol;Acc:MGI:1920175])

HSP 1 Score: 204.527 bits (519), Expect = 1.980e-60
Identity = 105/171 (61.40%), Postives = 131/171 (76.61%), Query Frame = 1

Query:  475 LSITSSNEVFCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIH----NGIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQN 972
            LS+  S +  CR C  E + ES L+TPC C+GTL+F+HQSCL +WIK  D R CELCKY+F M+   KPLR+W+KL+M+  E+RKI CSVTFH+IA+TCV+WSLYVLI+RT EEI     NG++EWP WTKL+VVAIGF GG+VFMYVQC++YV L R+   YNR   VQN
Sbjct:   66 LSVCPSTQDICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELCKYDFIMETKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAVTCVVWSLYVLIDRTAEEIKQGNDNGVLEWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQN 236

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BLAST of RING-CH-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q8TCQ1|MARH1_HUMAN (E3 ubiquitin-protein ligase MARCHF1 OS=Homo sapiens OX=9606 GN=MARCHF1 PE=1 SV=1)

HSP 1 Score: 204.527 bits (519), Expect = 1.227e-59
Identity = 105/171 (61.40%), Postives = 131/171 (76.61%), Query Frame = 1

Query:  475 LSITSSNEVFCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIH----NGIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQN 972
            LS+  S +  CR C  E + ES L+TPC C+GTL+F+HQSCL +WIK  D R CELCKY+F M+   KPLR+W+KL+M+  E+RKI CSVTFH+IA+TCV+WSLYVLI+RT EEI     NG++EWP WTKL+VVAIGF GG+VFMYVQC++YV L R+   YNR   VQN
Sbjct:   70 LSVCPSTQDICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELCKYDFIMETKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGNDNGVLEWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQN 240

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BLAST of RING-CH-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q6NZQ8|MARH1_MOUSE (E3 ubiquitin-protein ligase MARCHF1 OS=Mus musculus OX=10090 GN=Marchf1 PE=1 SV=2)

HSP 1 Score: 204.142 bits (518), Expect = 1.677e-59
Identity = 105/171 (61.40%), Postives = 131/171 (76.61%), Query Frame = 1

Query:  475 LSITSSNEVFCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIH----NGIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQN 972
            LS+  S +  CR C  E + ES L+TPC C+GTL+F+HQSCL +WIK  D R CELCKY+F M+   KPLR+W+KL+M+  E+RKI CSVTFH+IA+TCV+WSLYVLI+RT EEI     NG++EWP WTKL+VVAIGF GG+VFMYVQC++YV L R+   YNR   VQN
Sbjct:   70 LSVCPSTQDICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELCKYDFIMETKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAVTCVVWSLYVLIDRTAEEIKQGNDNGVLEWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQN 240

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BLAST of RING-CH-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q0VD59|MARH8_BOVIN (E3 ubiquitin-protein ligase MARCHF8 OS=Bos taurus OX=9913 GN=MARCHF8 PE=2 SV=1)

HSP 1 Score: 202.986 bits (515), Expect = 6.102e-59
Identity = 105/170 (61.76%), Postives = 132/170 (77.65%), Query Frame = 1

Query:  478 SITSSNEVFCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIH----NGIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQN 972
            S+T SN+  CR C  E + ES L+TPC C+G+L F+HQ+CLQ+WIK  D R CELCKYEF M+   KPLR+W+KL+M+  E+RKI+CSVTFH+IA+TCV+WSLYVLI+RT EEI      GI+EWP WTKL+VVAIGF GG++FMYVQC++YV L R+   YNR   VQN
Sbjct:   69 SVTPSNQDICRICHCEGDDESPLITPCRCTGSLHFVHQTCLQQWIKSSDTRCCELCKYEFIMETKLKPLRKWEKLQMTSSERRKIMCSVTFHVIAITCVVWSLYVLIDRTAEEIRQGQATGILEWPFWTKLVVVAIGFTGGLLFMYVQCKVYVQLWRRLKAYNRVIYVQN 238

[Close]

BLAST of RING-CH-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9DBD2|MARH8_MOUSE (E3 ubiquitin-protein ligase MARCHF8 OS=Mus musculus OX=10090 GN=Marchf8 PE=2 SV=1)

HSP 1 Score: 202.601 bits (514), Expect = 7.792e-59
Identity = 107/194 (55.15%), Postives = 138/194 (71.13%), Query Frame = 1

Query:  406 PMNQLPANQIDNSNSEQSNCNVNLSITSSNEVFCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIH----NGIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQN 972
            P N   A     S +   +     S+T SN+  CR C  E + ES L+TPC C+G+L F+HQ+CLQ+WIK  D R CELCKYEF M+   KPLR+W+KL+M+  E+RKI+CSVTFH+IA+TCV+WSLYVLI+RT EEI      GI+EWP WTKL+VVAIGF GG++FMYVQC++Y+ L ++   YNR   VQN
Sbjct:   43 PSNISKAGSSPPSTTAPVSAFSRTSVTPSNQDICRICHCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDTRCCELCKYEFIMETKLKPLRKWEKLQMTASERRKIMCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGQVTGILEWPFWTKLVVVAIGFTGGLLFMYVQCKVYLQLWKRLKAYNRVIYVQN 236

[Close]

BLAST of RING-CH-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q28IK8|MARH8_XENTR (E3 ubiquitin-protein ligase MARCHF8 OS=Xenopus tropicalis OX=8364 GN=marchf8 PE=2 SV=1)

HSP 1 Score: 200.29 bits (508), Expect = 2.250e-58
Identity = 103/170 (60.59%), Postives = 134/170 (78.82%), Query Frame = 1

Query:  478 SITSSNEVFCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEI----HNGIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQN 972
            S+T S++  CR C  E + ES L+TPC C+G+L F+HQ+CLQ+WIK  D R CELCK+EF M+   KPLR+W+KL+M+  E+RKI+CSVTFH+IA+TCV+WSLYVLI+RT EEI    +NGI+EWP WTKL+VVAIGF GG++FMYVQC++YV L ++   YNR   VQN
Sbjct:   44 SVTPSSQDICRICHCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDTRCCELCKFEFIMETKLKPLRKWEKLQMTASERRKIMCSVTFHVIAITCVVWSLYVLIDRTAEEIKMGQNNGILEWPFWTKLVVVAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQN 213

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BLAST of RING-CH-type domain-containing protein vs. TrEMBL
Match: K1RBI2 (E3 ubiquitin-protein ligase MARCH1 OS=Crassostrea gigas OX=29159 GN=CGI_10025922 PE=4 SV=1)

HSP 1 Score: 218.394 bits (555), Expect = 1.075e-62
Identity = 108/176 (61.36%), Postives = 135/176 (76.70%), Query Frame = 1

Query:  460 NCNVNLSITSSNEVFCRFCQ----EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIHNGIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQNI 975
             C  +LS+ SS +  CR CQ    E E +S L+ PCLC G++KF+HQ CLQ+WIK  D   CELCKYE++M    KP R+W++L+MS +E+RKI CSVTFH+IA+TCVIWSLYVLI+RTTEE+  G ++WP WTKLIVVAIGF GG+VFMYVQC+MYV LCRKW  YNR   V+N+
Sbjct:   51 RCETSLSMLSSGQDCCRICQCEVCEIEDDSPLIAPCLCDGSMKFVHQECLQKWIKSSDKECCELCKYEYKMTSKVKPFRKWERLQMSAVERRKITCSVTFHVIAITCVIWSLYVLIDRTTEEVEQGALDWPFWTKLIVVAIGFTGGLVFMYVQCKMYVRLCRKWKAYNRMITVENV 226

[Close]

BLAST of RING-CH-type domain-containing protein vs. TrEMBL
Match: A0A1S3IVG7 (E3 ubiquitin-protein ligase MARCH1 isoform X2 OS=Lingula unguis OX=7574 GN=LOC106167661 PE=4 SV=1)

HSP 1 Score: 217.238 bits (552), Expect = 1.560e-62
Identity = 107/183 (58.47%), Postives = 140/183 (76.50%), Query Frame = 1

Query:  436 DNSNSEQSNCNVNLSITSSNEVFCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIHNGIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQNITP 981
            ++++   + C    S   S    CR C  E E ++ L++PC+CSG+L+++HQ CLQ+WIK  D + CELC++EFRM   +KP R+W+K+EM+ ME+RKIICSVTFHIIA+TCVIWSLYVLI+RTT+EI NG++EWP WTKLIVV IGF GG+VFMYVQC+MYV LCR+W  YNR   +QN  P
Sbjct:   36 NSASPPLTECLSRPSTAGSLSEICRICHCESEVDNPLISPCVCSGSLRYVHQDCLQQWIKSADTKSCELCRFEFRMTTKTKPFRKWRKMEMTTMERRKIICSVTFHIIAITCVIWSLYVLIDRTTDEIENGMLEWPFWTKLIVVFIGFTGGLVFMYVQCKMYVQLCRRWKAYNRVIHIQNCPP 218

[Close]

BLAST of RING-CH-type domain-containing protein vs. TrEMBL
Match: A0A1S3IUR9 (E3 ubiquitin-protein ligase MARCH1 isoform X1 OS=Lingula unguis OX=7574 GN=LOC106167661 PE=4 SV=1)

HSP 1 Score: 217.624 bits (553), Expect = 1.942e-62
Identity = 109/194 (56.19%), Postives = 144/194 (74.23%), Query Frame = 1

Query:  403 VPMNQLPANQIDNSNSEQSNCNVNLSITSSNEVFCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIHNGIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQNITP 981
            +P+  +  N   +++   + C    S   S    CR C  E E ++ L++PC+CSG+L+++HQ CLQ+WIK  D + CELC++EFRM   +KP R+W+K+EM+ ME+RKIICSVTFHIIA+TCVIWSLYVLI+RTT+EI NG++EWP WTKLIVV IGF GG+VFMYVQC+MYV LCR+W  YNR   +QN  P
Sbjct:   44 IPLESIHQN---SASPPLTECLSRPSTAGSLSEICRICHCESEVDNPLISPCVCSGSLRYVHQDCLQQWIKSADTKSCELCRFEFRMTTKTKPFRKWRKMEMTTMERRKIICSVTFHIIAITCVIWSLYVLIDRTTDEIENGMLEWPFWTKLIVVFIGFTGGLVFMYVQCKMYVQLCRRWKAYNRVIHIQNCPP 234

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BLAST of RING-CH-type domain-containing protein vs. TrEMBL
Match: R7U7A4 (RING-CH-type domain-containing protein (Fragment) OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_45913 PE=4 SV=1)

HSP 1 Score: 213.001 bits (541), Expect = 9.010e-62
Identity = 105/168 (62.50%), Postives = 135/168 (80.36%), Query Frame = 1

Query:  472 NLSITSSNEVFCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIHNGIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQN 972
             +S+TSS    CR C  E E  + L++PC+C+G+LK++HQ CLQ+WIK  D + CELCK++F+M    KP R+WQKLEM+ +E+RK++CSVTFH+IA+TCVIWSLYVLI+RTTEEI  GI+EWP WTKLIVVAIGF GG+VFMYVQC+MY+ LCR+W  YNR   +QN
Sbjct:    9 TVSLTSSAGDLCRICHCEAEVGAPLISPCVCAGSLKYVHQRCLQQWIKSADTKSCELCKFDFQMTTKIKPFRKWQKLEMTTVERRKVLCSVTFHVIAITCVIWSLYVLIDRTTEEIKAGILEWPFWTKLIVVAIGFTGGLVFMYVQCKMYMQLCRRWKAYNRVIFIQN 176

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BLAST of RING-CH-type domain-containing protein vs. TrEMBL
Match: A0A1I8HE77 (RING-CH-type domain-containing protein OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 217.238 bits (552), Expect = 1.086e-61
Identity = 112/234 (47.86%), Postives = 148/234 (63.25%), Query Frame = 1

Query:  364 SVVINPKLICFQKVPMNQLPANQIDNSNSEQSNCNVNLSITSSNEVFCRFCQEYEPES-----------------ELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIHNGIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQNITPMELVAAQKEAK 1014
             VV+ P  +C   VPM        D             S   SNE+ CR C   E E+                  L++PCLCSGTLK++H+ CLQ W+K QD + CELC + F M +++KP+ EW+KL+M+ ME+RK+ICSV FH+IALTCV+WSLYVLIE+T  E+ +G +EW  WTKL+VVAIGF GG+VFMYVQCR Y  LCR+W  +NRTF++Q+ T  +L AA+   K
Sbjct:   79 GVVLTPLTLCAGAVPMPSASPAATD-------------SAADSNELICRICHSSETEAMAPASDNNSDCQTAAANPLISPCLCSGTLKYVHRDCLQYWVKSQDIKMCELCHFGFIMSVSTKPISEWRKLDMTPMERRKVICSVAFHVIALTCVVWSLYVLIEKTAMEVGSGKLEWSFWTKLVVVAIGFTGGLVFMYVQCRTYFGLCRRWRSFNRTFLIQSATEADLNAARDRVK 299

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BLAST of RING-CH-type domain-containing protein vs. Ensembl Cavefish
Match: march8 (membrane-associated ring finger (C3HC4) 8 [Source:ZFIN;Acc:ZDB-GENE-080204-8])

HSP 1 Score: 207.223 bits (526), Expect = 2.809e-60
Identity = 104/166 (62.65%), Postives = 133/166 (80.12%), Query Frame = 1

Query:  478 SITSSNEVFCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIHNGIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQN 972
            S+T SN+  CR C  E + ES L+TPC C+G+L+F+HQ+CLQ+WIK  D R CELCK+EF M+   KPLR+W+KL+M+  E+RKI+CSVTFH+IA+TCV+WSLYVLI+RT EEI  GI+EWP WTKL+VVAIGF GG+VFMYVQC++Y+ L R+   YNR   VQN
Sbjct:  178 SVTPSNQDICRICHCEGDDESPLITPCHCTGSLRFVHQACLQQWIKSSDTRCCELCKFEFIMETKLKPLRKWEKLQMTASERRKIMCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGILEWPFWTKLVVVAIGFTGGLVFMYVQCKVYIQLWRRLKAYNRVIYVQN 343

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BLAST of RING-CH-type domain-containing protein vs. Ensembl Cavefish
Match: march8 (membrane-associated ring finger (C3HC4) 8 [Source:ZFIN;Acc:ZDB-GENE-080204-8])

HSP 1 Score: 192.586 bits (488), Expect = 1.407e-52
Identity = 109/215 (50.70%), Postives = 144/215 (66.98%), Query Frame = 1

Query:  397 QKVPMNQLPAN-QIDNSNSEQSNCNVNLSITSSNEVFCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEI------------HNG---------IMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQN 972
            ++ P+  L  +  +D+ +S  S     LS  S +   CR C  E + ES L+TPC C+G+L+F+HQ+CLQ+WIK  D R CELCK+EF M+   KPLR+W+KL+M+  E+RKI+CSVTFH+IA+TCV+WSLYVLI+RT EEI            H G         I+EWP WTKL+VVAIGF GG+VFMYVQC++Y+ L R+   YNR   VQN
Sbjct:  405 RRAPLCSLEEDGDLDHCSSPVSEKTGPLSPYSLSGDCCRICHCEGDDESPLITPCHCTGSLRFVHQACLQQWIKSSDTRCCELCKFEFIMETKLKPLRKWEKLQMTASERRKIMCSVTFHVIAITCVVWSLYVLIDRTAEEIKQAGRIPGALKLHPGLTYGASKSRILEWPFWTKLVVVAIGFTGGLVFMYVQCKVYIQLWRRLKAYNRVIYVQN 619

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BLAST of RING-CH-type domain-containing protein vs. Ensembl Cavefish
Match: march1 (E3 ubiquitin-protein ligase MARCH8-like [Source:NCBI gene;Acc:103021385])

HSP 1 Score: 185.652 bits (470), Expect = 3.724e-51
Identity = 101/208 (48.56%), Postives = 135/208 (64.90%), Query Frame = 1

Query:  403 VPMNQLPANQIDNSNSEQSNCNVNLSITSSNEV-FCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIH----------------NGIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQN 972
             P  Q  AN  D + + Q  C       S +E+  CR C  E + +  L+TPC C+G+L+F+HQ+CL +WIK  D R CELCKY+F M+   KPLR+W+KL+MS  E+RKI CSVTFH++A+ CVIWSLY+LI RT EE+                  G++EWP WTKLIVVAIGF GG++FMY+QC++Y+ L R+   +NR   VQN
Sbjct:  259 APTAQKYANVADQNGTTQQAC-------SDDEMEVCRICHCEGDEDCPLITPCRCTGSLRFVHQACLHQWIKSSDTRCCELCKYDFIMETHLKPLRKWEKLQMSTSERRKIFCSVTFHLVAVVCVIWSLYILINRTAEELRLGKTNNALLRLSPLNAVGVLEWPFWTKLIVVAIGFTGGLIFMYIQCKVYLQLWRRLKAFNRVIFVQN 459

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BLAST of RING-CH-type domain-containing protein vs. Ensembl Cavefish
Match: march1 (E3 ubiquitin-protein ligase MARCH8-like [Source:NCBI gene;Acc:103021385])

HSP 1 Score: 185.652 bits (470), Expect = 5.619e-51
Identity = 101/208 (48.56%), Postives = 135/208 (64.90%), Query Frame = 1

Query:  403 VPMNQLPANQIDNSNSEQSNCNVNLSITSSNEV-FCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIH----------------NGIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQN 972
             P  Q  AN  D + + Q  C       S +E+  CR C  E + +  L+TPC C+G+L+F+HQ+CL +WIK  D R CELCKY+F M+   KPLR+W+KL+MS  E+RKI CSVTFH++A+ CVIWSLY+LI RT EE+                  G++EWP WTKLIVVAIGF GG++FMY+QC++Y+ L R+   +NR   VQN
Sbjct:  274 APTAQKYANVADQNGTTQQAC-------SDDEMEVCRICHCEGDEDCPLITPCRCTGSLRFVHQACLHQWIKSSDTRCCELCKYDFIMETHLKPLRKWEKLQMSTSERRKIFCSVTFHLVAVVCVIWSLYILINRTAEELRLGKTNNALLRLSPLNAVGVLEWPFWTKLIVVAIGFTGGLIFMYIQCKVYLQLWRRLKAFNRVIFVQN 474

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BLAST of RING-CH-type domain-containing protein vs. Ensembl Cavefish
Match: MARCHF3 (membrane associated ring-CH-type finger 3 [Source:NCBI gene;Acc:103035346])

HSP 1 Score: 78.1814 bits (191), Expect = 1.203e-15
Identity = 33/106 (31.13%), Postives = 56/106 (52.83%), Query Frame = 1

Query:  502 FCRFCQEYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIH 819
             CR C +   + EL++PC C+GTL  IH+SCL+ W+      FCELC Y+F ++  ++PL EW +      EKR +   +   ++       S ++ +    + +H
Sbjct:   85 MCRICHDGGGQEELLSPCECAGTLGTIHRSCLEHWLSASSTSFCELCHYQFSVQRKARPLLEWLRNPGLHQEKRTLFGDMVCFLLITPLATISGWLCLRGAVDHLH 190

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BLAST of RING-CH-type domain-containing protein vs. Ensembl Sea Lamprey
Match: march8 (membrane-associated ring finger (C3HC4) 8 [Source:ZFIN;Acc:ZDB-GENE-080204-8])

HSP 1 Score: 142.51 bits (358), Expect = 5.293e-39
Identity = 85/175 (48.57%), Postives = 120/175 (68.57%), Query Frame = 1

Query:  469 VNLSITSSNEVFCRF--CQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEI----HNGIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQN 972
            +++ +    ++ C F  C  E + E  L  PC C+G+L+F+HQ+CLQ+WIK      CELC Y F M+ T KPLR+W+KL+M+  + RK+  SV  H++A+ CV+WSLY+L+ RT EEI    H+G++EWP WTKL VVAIGF GG VFMYVQC++YV + R+   YNR   V++
Sbjct:    6 MSICVAIHTQLLCSFRICHCEGDEEGPLTAPCQCTGSLQFVHQACLQQWIKSSGASCCELCNYSFVMETTLKPLRKWEKLQMTARDMRKLTFSVVVHVVAIVCVVWSLYILVSRTAEEIRQAQHSGVLEWPFWTKLAVVAIGFTGGTVFMYVQCKVYVRMWRRLKAYNRIIHVRS 180

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BLAST of RING-CH-type domain-containing protein vs. Ensembl Sea Lamprey
Match: MARCHF3 (membrane associated ring-CH-type finger 3 [Source:HGNC Symbol;Acc:HGNC:28728])

HSP 1 Score: 78.1814 bits (191), Expect = 1.251e-16
Identity = 29/84 (34.52%), Postives = 50/84 (59.52%), Query Frame = 1

Query:  481 ITSSNEVFCRFCQEYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKII 732
            + S    FCR C E     EL++PC C GTL ++H++CL+RW+   +  +CELC ++F ++ T +P  +W +      E+R ++
Sbjct:   24 VASVESPFCRICHEAGSAEELLSPCECMGTLGWVHRACLERWLAASNTSYCELCHFQFLVERTPQPFSQWLRRPSPKQERRTLL 107

[Close]

BLAST of RING-CH-type domain-containing protein vs. Ensembl Sea Lamprey
Match: MARCHF3 (membrane associated ring-CH-type finger 3 [Source:HGNC Symbol;Acc:HGNC:28728])

HSP 1 Score: 77.0258 bits (188), Expect = 1.831e-16
Identity = 29/83 (34.94%), Postives = 50/83 (60.24%), Query Frame = 1

Query:  484 TSSNEVFCRFCQEYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKII 732
              S   FCR C E   + EL++PC C+GTL ++H+SCL+ W+   +  +CELC ++F ++   +PL +W +      E+R ++
Sbjct:    4 AGSESPFCRICHEGSAQEELLSPCECTGTLGWVHRSCLEHWLAASNTSYCELCHFQFLVERKPQPLTQWLRNPSPKQERRTLL 86

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BLAST of RING-CH-type domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002279.1 (pep scaffold:Pmarinus_7.0:GL492175:3127:4977:-1 gene:ENSPMAG00000002079.1 transcript:ENSPMAT00000002279.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 62.3882 bits (150), Expect = 2.972e-12
Identity = 24/51 (47.06%), Postives = 34/51 (66.67%), Query Frame = 1

Query:  505 CRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEF 654
            CR C+ E   E  L  PC+C+G++K+IHQ CL +W+K     +CELCK+ F
Sbjct:    5 CRVCRSEGTAEKPLYHPCVCTGSIKYIHQDCLLQWLKHSKKEYCELCKHRF 55

[Close]

BLAST of RING-CH-type domain-containing protein vs. Ensembl Sea Lamprey
Match: MARCHF4 (membrane associated ring-CH-type finger 4 [Source:HGNC Symbol;Acc:HGNC:29269])

HSP 1 Score: 61.6178 bits (148), Expect = 4.819e-11
Identity = 28/87 (32.18%), Postives = 52/87 (59.77%), Query Frame = 1

Query:  532 ESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMK-ITSKPLREWQKLEMSIMEK---RKIICSVTFHIIALTCVIWS 780
            + EL+ PC C+G++++ HQ CL  WI  + +  CELC Y+FR++ + +K   +WQ + +S +E+     +     F + +L  ++WS
Sbjct:    3 QGELLNPCRCNGSVRWTHQPCLLTWISERGSWSCELCYYKFRVRPVNTKHPTQWQGVSLSPIERVQAAAVSLGCLFLLASLVWLVWS 89

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BLAST of RING-CH-type domain-containing protein vs. Ensembl Nematostella
Match: EDO37870 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SEJ1])

HSP 1 Score: 193.741 bits (491), Expect = 1.994e-58
Identity = 99/174 (56.90%), Postives = 133/174 (76.44%), Query Frame = 1

Query:  478 SITSSNEVFCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIHNGIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQNITPMELVA 996
            S+ SS    CR C  E EP+  L++PC CSG+L+++HQ+CLQRWIK  D + CELC YEF M+   KP R+WQ L+M+  E+RKI+CSV+FHIIA+TCV+WSL+VLIERT +EI +G ++WP WTKL+VVAIGF GG+VFMYVQC++YV L ++   YNR  +VQ++ P +  A
Sbjct:    1 SVASSCLEICRICHCEAEPDQPLISPCHCSGSLQYVHQTCLQRWIKSSDTKKCELCNYEFIMEAKMKPFRKWQALDMTRSERRKIMCSVSFHIIAITCVVWSLWVLIERTAQEIRSGKLDWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWKRLRAYNRIIMVQDVPPAQETA 174

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BLAST of RING-CH-type domain-containing protein vs. Ensembl Nematostella
Match: EDO37249 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SGD2])

HSP 1 Score: 69.3218 bits (168), Expect = 5.907e-14
Identity = 34/90 (37.78%), Postives = 50/90 (55.56%), Query Frame = 1

Query:  505 CRFCQEYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVI 774
            CR C++     ++++PC CSGTL  +H  CL+ W+   +   CE+CKYE+ ++ T K  R+W K   S  E+R II      II    VI
Sbjct:    1 CRICRDSTAGCDVISPCHCSGTLGRVHVRCLEEWLSASNKNECEICKYEYHLQRTPKTFRQWLKNPRSRTERRYIIGDCACFIILTPLVI 90

[Close]

BLAST of RING-CH-type domain-containing protein vs. Ensembl Nematostella
Match: EDO31642 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SXB2])

HSP 1 Score: 67.0106 bits (162), Expect = 3.667e-12
Identity = 27/76 (35.53%), Postives = 47/76 (61.84%), Query Frame = 1

Query:  493 NEVFCRFCQ----EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMS 708
            +E  CR CQ        + EL+ PCLC+GTL + H+SC+++W+ + + + C +C++ F+ K   KP+ +W  L M+
Sbjct:   64 DEPMCRICQNTVQRMIGKEELIKPCLCNGTLGYAHRSCMEQWLTLTEKKKCTICEFTFKTKTVLKPITQWTWLPMT 139

[Close]

BLAST of RING-CH-type domain-containing protein vs. Ensembl Nematostella
Match: EDO43593 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RY85])

HSP 1 Score: 65.4698 bits (158), Expect = 1.357e-11
Identity = 35/99 (35.35%), Postives = 50/99 (50.51%), Query Frame = 1

Query:  412 NQLPANQIDNSNSEQSNCNVN----LSITSSNEVFCRFCQEYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITS-KPLREWQ 693
            N+   N++  +  E S CN       S + S EV CR C        L+ PC C G+ K++HQSCL  W   + ++ CELC Y+  MK    KP  +W+
Sbjct:  115 NRGLGNEVPETTLELSLCNTRSTGKASPSLSCEVICRICHGGPTTEMLIAPCRCCGSAKYVHQSCLLMWFDRKQDKTCELCLYKVEMKPKGLKPPTKWK 213

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BLAST of RING-CH-type domain-containing protein vs. Ensembl Nematostella
Match: EDO40361 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S7B1])

HSP 1 Score: 65.0846 bits (157), Expect = 1.501e-11
Identity = 30/66 (45.45%), Postives = 37/66 (56.06%), Query Frame = 1

Query:  505 CRFCQEYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLE 702
            CR C     E  LVTPC CSG+ KF+H +CL  W K      CELC+ +  +K   KP  EW+K E
Sbjct:  114 CRICHSAG-EEPLVTPCHCSGSAKFVHATCLLTWFKKAVKNTCELCRCKVAIKKKGKPFAEWRKPE 178

[Close]

BLAST of RING-CH-type domain-containing protein vs. Ensembl Medaka
Match: march8 (membrane associated ring-CH-type finger 8 [Source:NCBI gene;Acc:101161433])

HSP 1 Score: 205.682 bits (522), Expect = 4.678e-61
Identity = 102/166 (61.45%), Postives = 133/166 (80.12%), Query Frame = 1

Query:  478 SITSSNEVFCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIHNGIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQN 972
            S++ S++  CR C  E + ES L+TPC C+G+L+F+HQ CLQ+WIK  D R CELCKYEF M+   KPLR+W+KL+M+  E+RKI+CSVTFHIIA+TCV+WSLYVLI+RT +EI +GI+EWP WTKL+VVAIGF GG+VFMYVQC++Y+ L ++   YNR   VQN
Sbjct:   66 SVSPSSQDICRICHCEGDEESPLITPCHCTGSLRFVHQGCLQQWIKSSDTRCCELCKYEFIMETKFKPLRKWEKLQMTASERRKIMCSVTFHIIAITCVVWSLYVLIDRTADEIRSGILEWPFWTKLVVVAIGFTGGLVFMYVQCKVYIHLWKRLKAYNRVIYVQN 231

[Close]

BLAST of RING-CH-type domain-containing protein vs. Ensembl Medaka
Match: march8 (membrane associated ring-CH-type finger 8 [Source:NCBI gene;Acc:101161433])

HSP 1 Score: 199.519 bits (506), Expect = 9.498e-59
Identity = 102/171 (59.65%), Postives = 133/171 (77.78%), Query Frame = 1

Query:  478 SITSSNEVFCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIHN-----GIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQN 972
            S++ S++  CR C  E + ES L+TPC C+G+L+F+HQ CLQ+WIK  D R CELCKYEF M+   KPLR+W+KL+M+  E+RKI+CSVTFHIIA+TCV+WSLYVLI+RT +EI +     GI+EWP WTKL+VVAIGF GG+VFMYVQC++Y+ L ++   YNR   VQN
Sbjct:   66 SVSPSSQDICRICHCEGDEESPLITPCHCTGSLRFVHQGCLQQWIKSSDTRCCELCKYEFIMETKFKPLRKWEKLQMTASERRKIMCSVTFHIIAITCVVWSLYVLIDRTADEIRSAGRIPGILEWPFWTKLVVVAIGFTGGLVFMYVQCKVYIHLWKRLKAYNRVIYVQN 236

[Close]

BLAST of RING-CH-type domain-containing protein vs. Ensembl Medaka
Match: march8 (membrane associated ring-CH-type finger 8 [Source:NCBI gene;Acc:101161433])

HSP 1 Score: 197.978 bits (502), Expect = 1.640e-58
Identity = 102/169 (60.36%), Postives = 133/169 (78.70%), Query Frame = 1

Query:  478 SITSSNEVFCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIHNG---IMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQN 972
            S++ S++  CR C  E + ES L+TPC C+G+L+F+HQ CLQ+WIK  D R CELCKYEF M+   KPLR+W+KL+M+  E+RKI+CSVTFHIIA+TCV+WSLYVLI+RT +EI +G   I+EWP WTKL+VVAIGF GG+VFMYVQC++Y+ L ++   YNR   VQN
Sbjct:   42 SVSPSSQDICRICHCEGDEESPLITPCHCTGSLRFVHQGCLQQWIKSSDTRCCELCKYEFIMETKFKPLRKWEKLQMTASERRKIMCSVTFHIIAITCVVWSLYVLIDRTADEIRSGQHRILEWPFWTKLVVVAIGFTGGLVFMYVQCKVYIHLWKRLKAYNRVIYVQN 210

[Close]

BLAST of RING-CH-type domain-containing protein vs. Ensembl Medaka
Match: march8 (membrane associated ring-CH-type finger 8 [Source:NCBI gene;Acc:101161433])

HSP 1 Score: 197.593 bits (501), Expect = 2.635e-58
Identity = 102/171 (59.65%), Postives = 133/171 (77.78%), Query Frame = 1

Query:  478 SITSSNEVFCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIHN-----GIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQN 972
            S++ S++  CR C  E + ES L+TPC C+G+L+F+HQ CLQ+WIK  D R CELCKYEF M+   KPLR+W+KL+M+  E+RKI+CSVTFHIIA+TCV+WSLYVLI+RT +EI +     GI+EWP WTKL+VVAIGF GG+VFMYVQC++Y+ L ++   YNR   VQN
Sbjct:   44 SVSPSSQDICRICHCEGDEESPLITPCHCTGSLRFVHQGCLQQWIKSSDTRCCELCKYEFIMETKFKPLRKWEKLQMTASERRKIMCSVTFHIIAITCVVWSLYVLIDRTADEIRSAGRIPGILEWPFWTKLVVVAIGFTGGLVFMYVQCKVYIHLWKRLKAYNRVIYVQN 214

[Close]

BLAST of RING-CH-type domain-containing protein vs. Ensembl Medaka
Match: march1 (E3 ubiquitin-protein ligase MARCH1 [Source:NCBI gene;Acc:101155329])

HSP 1 Score: 178.333 bits (451), Expect = 1.464e-48
Identity = 96/194 (49.48%), Postives = 131/194 (67.53%), Query Frame = 1

Query:  454 QSNCNVNLSIT-----SSNEVFCRFCQ-EYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEI---HNGIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQNITPMELVAAQKE 1008
            Q +C VN  +       S    CR C  E + E  L+ PC C+G+L F+HQ+CL +WIK  D R CELCK++F M+   KPL +W+KL MS  E+RKI CSV FH+IA+ C++WS+Y+L++RTTEEI    NG++EWP WTKLIVVAIGF GG++FMY+QC++Y+ L R+   +NR   VQN     L  +Q +
Sbjct:  273 QKHCGVNGGLPRPCSEDSELEVCRICHCEGDDEFPLIMPCRCTGSLSFVHQACLNQWIKSSDTRCCELCKFDFIMETKLKPLNKWEKLHMSKSERRKIFCSVLFHLIAILCMLWSVYILVKRTTEEIKLGKNGVLEWPFWTKLIVVAIGFTGGLIFMYIQCKVYLQLWRRLKAFNRIITVQNCPEKNLHKSQTQ 466

[Close]

BLAST of RING-CH-type domain-containing protein vs. Planmine SMEST
Match: SMESG000056612.1 (SMESG000056612.1)

HSP 1 Score: 695.656 bits (1794), Expect = 0.000e+0
Identity = 383/383 (100.00%), Postives = 383/383 (100.00%), Query Frame = 1

Query:   73 MNRVSPLNEIXXXXXXXXXXXXXXILMTDKGDTLPDIPDISQNLNQDDLNRNSRNVIITIKDESTSDNTNKIDSTNQMSAIVKFIRSSFWSNKKKSESVVINPKLICFQKVPMNQLPANQIDNSNSEQSNCNVNLSITSSNEVFCRFCQEYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIHNGIMEWPLWTKLXXXXXXXXXXXXXMYVQCRMYVSLCRKWHIYNRTFIVQNITPMELVAAQKEAKLKCEDYQKNIQFGRTQLFGDVSIEXXXXXXXXXXXXXILGASSDEYDFTSPSETDMPNYCEKIFSSGEF 1221
            MNRVSPLNEIDLTNSLNSSSQTSDILMTDKGDTLPDIPDISQNLNQDDLNRNSRNVIITIKDESTSDNTNKIDSTNQMSAIVKFIRSSFWSNKKKSESVVINPKLICFQKVPMNQLPANQIDNSNSEQSNCNVNLSITSSNEVFCRFCQEYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIHNGIMEWPLWTKLIVVAIGFIGGVVFMYVQCRMYVSLCRKWHIYNRTFIVQNITPMELVAAQKEAKLKCEDYQKNIQFGRTQLFGDVSIETVPNVNVNVVNTPILGASSDEYDFTSPSETDMPNYCEKIFSSGEF
Sbjct:    1 MNRVSPLNEIDLTNSLNSSSQTSDILMTDKGDTLPDIPDISQNLNQDDLNRNSRNVIITIKDESTSDNTNKIDSTNQMSAIVKFIRSSFWSNKKKSESVVINPKLICFQKVPMNQLPANQIDNSNSEQSNCNVNLSITSSNEVFCRFCQEYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIHNGIMEWPLWTKLIVVAIGFIGGVVFMYVQCRMYVSLCRKWHIYNRTFIVQNITPMELVAAQKEAKLKCEDYQKNIQFGRTQLFGDVSIETVPNVNVNVVNTPILGASSDEYDFTSPSETDMPNYCEKIFSSGEF 383

[Close]

BLAST of RING-CH-type domain-containing protein vs. Planmine SMEST
Match: SMESG000044972.1 (SMESG000044972.1)

HSP 1 Score: 55.4546 bits (132), Expect = 3.485e-8
Identity = 19/62 (30.65%), Postives = 34/62 (54.84%), Query Frame = 1

Query:  505 CRFCQEYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREW 690
            CR C +     +L++PC C G++  IH++CL++W+       CE+C +EF +   +     W
Sbjct:   29 CRVCLDSCDMGDLISPCFCKGSIGVIHKNCLEKWLTAARIGQCEICGFEFFVSTNTASFSRW 90

[Close]

BLAST of RING-CH-type domain-containing protein vs. Planmine SMEST
Match: SMESG000031839.1 (SMESG000031839.1)

HSP 1 Score: 55.0694 bits (131), Expect = 4.426e-8
Identity = 19/62 (30.65%), Postives = 34/62 (54.84%), Query Frame = 1

Query:  505 CRFCQEYEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREW 690
            CR C +     +L++PC C G++  IH++CL++W+       CE+C +EF +   +     W
Sbjct:   29 CRVCLDSCDMGDLISPCFCKGSIGVIHKNCLEKWLTAARIGQCEICGFEFFVSTKTASFSRW 90

[Close]

BLAST of RING-CH-type domain-containing protein vs. Planmine SMEST
Match: SMESG000003896.1 (SMESG000003896.1)

HSP 1 Score: 55.4546 bits (132), Expect = 4.950e-8
Identity = 22/63 (34.92%), Postives = 36/63 (57.14%), Query Frame = 1

Query:  505 CRFCQEYEPESE-LVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITSKPLREW 690
            CR C + E   E L++PC C GT+  +H +CL+ WI++ +   CE+CK  + M+     +  W
Sbjct:  128 CRICLDLEKNGEKLMSPCRCKGTVGLMHSTCLEEWIRISEKEQCEICKCNYDMRKKRADMHMW 190

[Close]

BLAST of RING-CH-type domain-containing protein vs. Planmine SMEST
Match: SMESG000023151.1 (SMESG000023151.1)

HSP 1 Score: 55.8398 bits (133), Expect = 7.251e-8
Identity = 44/147 (29.93%), Postives = 76/147 (51.70%), Query Frame = 1

Query:  274 NTNKIDSTNQMSAIVKFIRSSFWSNKKKSESVVINPKL-ICF-QKVPMNQLPANQIDNSNSEQSNCN--VNLSITSSNEVF----CRFCQ-EYEPESEL-VTPCLCSGTLKFIHQSCLQRWIKVQDNR----------FCELCKYEF 654
            N N+ + T+    I+    + F +N  +S +V  N ++  CF  K+P N    N+ D+ +S   + +   + SI S+  +     CRFC      +S+L ++PC CSGTLK++HQ+CL+ W+ V   +           CELC +++
Sbjct:   92 NHNRPEKTDNDRGIIICTCNDFVNNNFRSRNVFDNFQMDKCFLPKIPPNPQSHNRQDSIDSPDKSIDDQHDNSIYSNGSILSDPMCRFCHLSKNTQSDLLISPCYCSGTLKYVHQNCLKTWLDVSKKQKSNHSGDKSPHCELCNFKY 238

The following BLAST results are available for this feature:

BLAST of RING-CH-type domain-containing protein vs. Ensembl Human
BLAST of RING-CH-type domain-containing protein vs. Ensembl Celegans
BLAST of RING-CH-type domain-containing protein vs. Ensembl Fly
BLAST of RING-CH-type domain-containing protein vs. Ensembl Zebrafish
BLAST of RING-CH-type domain-containing protein vs. Ensembl Xenopus
BLAST of RING-CH-type domain-containing protein vs. Ensembl Mouse
BLAST of RING-CH-type domain-containing protein vs. UniProt/SwissProt
BLAST of RING-CH-type domain-containing protein vs. TrEMBL
BLAST of RING-CH-type domain-containing protein vs. Ensembl Cavefish
BLAST of RING-CH-type domain-containing protein vs. Ensembl Sea Lamprey
BLAST of RING-CH-type domain-containing protein vs. Ensembl Yeast
BLAST of RING-CH-type domain-containing protein vs. Ensembl Nematostella
BLAST of RING-CH-type domain-containing protein vs. Ensembl Medaka
BLAST of RING-CH-type domain-containing protein vs. Planmine SMEST

BLAST of RING-CH-type domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
MARCHF1	2.555e-60	61.40	membrane associated ring-CH-type finger 1 [Source:...	[more]
MARCHF1	2.555e-60	61.40	membrane associated ring-CH-type finger 1 [Source:...	[more]
MARCHF1	8.151e-60	61.40	membrane associated ring-CH-type finger 1 [Source:...	[more]
MARCHF8	2.330e-58	61.18	membrane associated ring-CH-type finger 8 [Source:...	[more]
MARCHF8	2.330e-58	61.18	membrane associated ring-CH-type finger 8 [Source:...	[more]

BLAST of RING-CH-type domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
marc-1	2.826e-11	35.44	MARCH (Membrane-Associated Ring finger (C3HC4)) ho...	[more]
marc-2	1.025e-8	32.43	MARCH (Membrane-Associated Ring finger (C3HC4)) ho...	[more]
marc-3	1.598e-8	28.13	MARCH (Membrane-Associated Ring finger (C3HC4)) ho...	[more]
marc-5	1.947e-8	39.39	MARCH (Membrane-Associated Ring finger (C3HC4)) ho...	[more]
marc-4	2.979e-8	36.76	MARCH (Membrane-Associated Ring finger (C3HC4)) ho...	[more]

BLAST of RING-CH-type domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
CG4080	1.271e-47	43.78	gene:FBgn0035983 transcript:FBtr0309506	[more]
CG4080	1.271e-47	43.78	gene:FBgn0035983 transcript:FBtr0076494	[more]
CG13442	8.026e-11	29.53	gene:FBgn0034546 transcript:FBtr0086240	[more]
CG1317	3.898e-10	40.68	gene:FBgn0035333 transcript:FBtr0300773	[more]
CG1317	3.898e-10	40.68	gene:FBgn0035333 transcript:FBtr0072901	[more]

BLAST of RING-CH-type domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
march8	2.323e-62	62.65	membrane-associated ring finger (C3HC4) 8 [Source:...	[more]
march8	3.045e-54	53.47	membrane-associated ring finger (C3HC4) 8 [Source:...	[more]
march1	7.563e-53	52.49	membrane-associated ring finger (C3HC4) 1 [Source:...	[more]
march1	1.415e-49	53.18	membrane-associated ring finger (C3HC4) 1 [Source:...	[more]
march1	1.415e-49	53.18	membrane-associated ring finger (C3HC4) 1 [Source:...	[more]

BLAST of RING-CH-type domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
faf1	3.506e-59	60.59	Fas (TNFRSF6) associated factor 1 [Source:Xenbase;...	[more]
faf1	7.208e-59	60.59	Fas (TNFRSF6) associated factor 1 [Source:Xenbase;...	[more]
faf1	8.269e-59	60.59	Fas (TNFRSF6) associated factor 1 [Source:Xenbase;...	[more]
faf1	9.122e-59	60.59	Fas (TNFRSF6) associated factor 1 [Source:Xenbase;...	[more]
ube2a	8.764e-57	60.12	ubiquitin conjugating enzyme E2 A [Source:Xenbase;...	[more]

BLAST of RING-CH-type domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
March1	1.459e-61	62.28	membrane-associated ring finger (C3HC4) 1 [Source:...	[more]
March1	1.459e-61	62.28	membrane-associated ring finger (C3HC4) 1 [Source:...	[more]
March1	5.336e-61	62.28	membrane-associated ring finger (C3HC4) 1 [Source:...	[more]
March1	1.980e-60	61.40	membrane-associated ring finger (C3HC4) 1 [Source:...	[more]
March1	1.980e-60	61.40	membrane-associated ring finger (C3HC4) 1 [Source:...	[more]

BLAST of RING-CH-type domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q8TCQ1\|MARH1_HUMAN	1.227e-59	61.40	E3 ubiquitin-protein ligase MARCHF1 OS=Homo sapien...	[more]
sp\|Q6NZQ8\|MARH1_MOUSE	1.677e-59	61.40	E3 ubiquitin-protein ligase MARCHF1 OS=Mus musculu...	[more]
sp\|Q0VD59\|MARH8_BOVIN	6.102e-59	61.76	E3 ubiquitin-protein ligase MARCHF8 OS=Bos taurus ...	[more]
sp\|Q9DBD2\|MARH8_MOUSE	7.792e-59	55.15	E3 ubiquitin-protein ligase MARCHF8 OS=Mus musculu...	[more]
sp\|Q28IK8\|MARH8_XENTR	2.250e-58	60.59	E3 ubiquitin-protein ligase MARCHF8 OS=Xenopus tro...	[more]

BLAST of RING-CH-type domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
K1RBI2	1.075e-62	61.36	E3 ubiquitin-protein ligase MARCH1 OS=Crassostrea ...	[more]
A0A1S3IVG7	1.560e-62	58.47	E3 ubiquitin-protein ligase MARCH1 isoform X2 OS=L...	[more]
A0A1S3IUR9	1.942e-62	56.19	E3 ubiquitin-protein ligase MARCH1 isoform X1 OS=L...	[more]
R7U7A4	9.010e-62	62.50	RING-CH-type domain-containing protein (Fragment) ...	[more]
A0A1I8HE77	1.086e-61	47.86	RING-CH-type domain-containing protein OS=Macrosto...	[more]

BLAST of RING-CH-type domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
march8	2.809e-60	62.65	membrane-associated ring finger (C3HC4) 8 [Source:...	[more]
march8	1.407e-52	50.70	membrane-associated ring finger (C3HC4) 8 [Source:...	[more]
march1	3.724e-51	48.56	E3 ubiquitin-protein ligase MARCH8-like [Source:NC...	[more]
march1	5.619e-51	48.56	E3 ubiquitin-protein ligase MARCH8-like [Source:NC...	[more]
MARCHF3	1.203e-15	31.13	membrane associated ring-CH-type finger 3 [Source:...	[more]

BLAST of RING-CH-type domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
march8	5.293e-39	48.57	membrane-associated ring finger (C3HC4) 8 [Source:...	[more]
MARCHF3	1.251e-16	34.52	membrane associated ring-CH-type finger 3 [Source:...	[more]
MARCHF3	1.831e-16	34.94	membrane associated ring-CH-type finger 3 [Source:...	[more]
ENSPMAT00000002279.1	2.972e-12	47.06	pep scaffold:Pmarinus_7.0:GL492175:3127:4977:-1 ge...	[more]
MARCHF4	4.819e-11	32.18	membrane associated ring-CH-type finger 4 [Source:...	[more]

BLAST of RING-CH-type domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of RING-CH-type domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO37870	1.994e-58	56.90	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO37249	5.907e-14	37.78	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO31642	3.667e-12	35.53	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO43593	1.357e-11	35.35	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO40361	1.501e-11	45.45	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of RING-CH-type domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
march8	4.678e-61	61.45	membrane associated ring-CH-type finger 8 [Source:...	[more]
march8	9.498e-59	59.65	membrane associated ring-CH-type finger 8 [Source:...	[more]
march8	1.640e-58	60.36	membrane associated ring-CH-type finger 8 [Source:...	[more]
march8	2.635e-58	59.65	membrane associated ring-CH-type finger 8 [Source:...	[more]
march1	1.464e-48	49.48	E3 ubiquitin-protein ligase MARCH1 [Source:NCBI ge...	[more]

BLAST of RING-CH-type domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000056612.1	0.000e+0	100.00	SMESG000056612.1	[more]
SMESG000044972.1	3.485e-8	30.65	SMESG000044972.1	[more]
SMESG000031839.1	4.426e-8	30.65	SMESG000031839.1	[more]
SMESG000003896.1	4.950e-8	34.92	SMESG000003896.1	[more]
SMESG000023151.1	7.251e-8	29.93	SMESG000023151.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30030835 ID=SMED30030835|Name=RING-CH-type domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1916bp
ATTTTATTTTATCGATTATTTATTTCTATTGTAAATGAAAATTTATTTTT
AATTTAATAGATTTCCCATGTTATGAATCGTGTGTCACCATTAAATGAAA
TTGATCTCACCAATAGTCTAAATTCATCAAGCCAAACTTCTGATATTCTT
ATGACAGATAAAGGTGACACTTTACCAGACATTCCCGATATTTCTCAGAA
TTTAAATCAAGATGATCTCAATCGAAACTCTCGTAATGTGATAATTACAA
TAAAAGATGAATCAACAAGTGATAATACAAATAAAATCGACTCAACAAAT
CAAATGTCAGCAATTGTAAAATTTATTAGAAGCTCTTTTTGGTCAAATAA
GAAAAAATCGGAAAGTGTTGTAATTAATCCGAAATTGATTTGCTTTCAAA
AAGTACCAATGAATCAATTACCAGCCAATCAAATCGATAATTCCAATTCG
GAGCAATCCAATTGCAATGTGAATTTATCAATAACCTCCAGCAATGAAGT
GTTTTGCAGATTCTGTCAAGAATATGAGCCAGAATCGGAACTAGTGACGC
CTTGCTTGTGTTCGGGAACTTTAAAATTTATTCATCAATCCTGCCTCCAA
AGATGGATAAAAGTTCAAGACAATCGATTTTGTGAGCTATGTAAATATGA
GTTCCGAATGAAAATAACATCAAAACCACTGAGAGAGTGGCAAAAGCTCG
AAATGAGCATAATGGAAAAACGGAAAATTATTTGTTCAGTAACATTTCAT
ATCATAGCCTTAACGTGTGTTATTTGGTCACTTTATGTTCTCATTGAACG
AACGACCGAAGAAATCCACAACGGAATTATGGAATGGCCTTTGTGGACGA
AGCTTATCGTTGTAGCAATCGGATTTATAGGTGGTGTAGTGTTTATGTAT
GTTCAATGTCGAATGTACGTTTCGTTATGTCGTAAATGGCACATTTACAA
TAGGACATTTATCGTTCAAAATATCACTCCTATGGAACTTGTTGCCGCTC
AAAAAGAGGCAAAATTGAAGTGTGAAGATTATCAGAAAAATATCCAATTT
GGAAGAACACAATTATTCGGTGACGTATCGATTGAGACAGTGCCAAATGT
GAATGTCAATGTTGTTAACACGCCGATTCTCGGAGCCAGTAGTGATGAAT
ATGATTTTACTTCTCCTTCAGAAACTGACATGCCAAATTATTGTGAAAAA
ATCTTCAGCAGTGGTGAATTCAATACTAGAAACATTTCCTAATAATCAAA
TAATGTGAATGAAATTCCCAATTCCACCTCAATGCTTTCGTACCTCGGAG
AATAATTTATCAATTTTGTAGCTGTGCTCGATCCGTGCTTTAATCTTTAA
TTTCTAAATCAAGGTAAAGTATAGACTACAGTTCCTATGCTTCTATATTT
ACATATATATGATAATTATTTACTATTTTTCATTATCTAGAATGTTACTA
CAATATTTCTTTGTTATTTGAACTATTCAACAAATTCTGATGTTTTAAAT
TAATCTGATTGGACTATTTGATTGAACGATTTCACATTAAAAATATTCTG
ATTATTATATTATTTGGTAGCTATTAAATTAATAAATCAACAACATATCT
TTGAACTTCTTAGAGCGGATTCTTAGAGTGGAACTCTAGATCATCGATTC
CCAACTGGTTTTTGTTAGCATCCCAAAAGTTTGATACGAATTTCATTATT
TCAAATTATGTCAATTATGCAGTGATATCAGTGATATTTTCACTGATTTT
CTTCAAATTTAGCGTACTTTTGTAAAGAACATTTGGGAGTGAAAACGTTC
CAAACATCATGTCAACATACAAAAAAACAAAACGTCACTCGAATTGGGAA
CCCCTGATCTAGATGAATATTTTATAATATGAATATAAGTTTTACATAAA
GATTATACGGTAGCAA

protein sequence of SMED30030835-orf-1

>SMED30030835-orf-1 ID=SMED30030835-orf-1|Name=SMED30030835-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=390bp
MNRVSPLNEIDLTNSLNSSSQTSDILMTDKGDTLPDIPDISQNLNQDDLN
RNSRNVIITIKDESTSDNTNKIDSTNQMSAIVKFIRSSFWSNKKKSESVV
INPKLICFQKVPMNQLPANQIDNSNSEQSNCNVNLSITSSNEVFCRFCQE
YEPESELVTPCLCSGTLKFIHQSCLQRWIKVQDNRFCELCKYEFRMKITS
KPLREWQKLEMSIMEKRKIICSVTFHIIALTCVIWSLYVLIERTTEEIHN
GIMEWPLWTKLIVVAIGFIGGVVFMYVQCRMYVSLCRKWHIYNRTFIVQN
ITPMELVAAQKEAKLKCEDYQKNIQFGRTQLFGDVSIETVPNVNVNVVNT
PILGASSDEYDFTSPSETDMPNYCEKIFSSGEFNTRNIS*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000026	gut
PLANA:0000034	epidermis
PLANA:0000204	ovary
PLANA:0000208	testis

Vocabulary: **INTERPRO**
Term	Definition
IPR011016	Znf_RING-CH
IPR013083	Znf_RING/FYVE/PHD

Vocabulary: **molecular function**
Term	Definition
GO:0008270	zinc ion binding
GO:0004842	ubiquitin-protein transferase activity
GO:0016740	transferase activity
GO:0042289	MHC class II protein binding
GO:0046872	metal ion binding
GO:0061630	ubiquitin protein ligase activity

Vocabulary: **biological process**
Term	Definition
GO:0002250	adaptive immune response
GO:0002376	immune system process
GO:0002495	antigen processing and presentation of peptide antigen via MHC class II
GO:0016567	protein ubiquitination
GO:0045347	negative regulation of MHC class II biosynthetic process

Vocabulary: **cellular component**
Term	Definition
GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030659	cytoplasmic vesicle membrane
GO:0031410	cytoplasmic vesicle
GO:0031901	early endosome membrane

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR011016	Zinc finger, RING-CH-type	SMART	SM00744	ringv_2	coord: 144..191 e-value: 1.3E-19 score: 81.2
IPR011016	Zinc finger, RING-CH-type	PFAM	PF12906	RINGv	coord: 145..190 e-value: 9.6E-14 score: 51.2
IPR011016	Zinc finger, RING-CH-type	PROSITE	PS51292	ZF_RING_CH	coord: 137..197 score: 22.443
IPR013083	Zinc finger, RING/FYVE/PHD-type	GENE3D	G3DSA:3.30.40.10		coord: 128..204 e-value: 3.0E-22 score: 80.0
None	No IPR available	PANTHER	PTHR45981:SF4	E3 UBIQUITIN-PROTEIN LIGASE MARCH8	coord: 42..301
None	No IPR available	PANTHER	PTHR45981	FAMILY NOT NAMED	coord: 42..301
None	No IPR available	SUPERFAMILY	SSF57850	RING/U-box	coord: 139..195
None	No IPR available	TMHMM	TMhelix		coord: 256..278
None	No IPR available	TMHMM	TMhelix		coord: 219..241

Main menu

RING-CH-type domain-containing protein

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 4

Owlery

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