ENTH domain-containing protein

Overview


Name	ENTH domain-containing protein
Smed ID	SMED30030824
Length (bp)	1818

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of ENTH domain-containing protein (SMED30030824) t-SNE clustered cells

Violin plots show distribution of expression levels for ENTH domain-containing protein (SMED30030824) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of ENTH domain-containing protein (SMED30030824) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for ENTH domain-containing protein (SMED30030824) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30030824

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 16

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
protonephridia	SMED30030824	SMESG000019746.1	dd_Smed_v4_1065_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
gut	SMED30030824	SMESG000019746.1	dd_Smed_v4_1065_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30030824	SMESG000019746.1	dd_Smed_v4_1065_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30030824	SMESG000019746.1	dd_Smed_v4_1065_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30030824	SMESG000019746.1	dd_Smed_v4_1065_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
muscle cell	SMED30030824	SMESG000019746.1	dd_Smed_v4_1065_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30030824	SMESG000019746.1	Contig40019	newmark_ests	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30030824	SMESG000019746.1	Contig40019	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
testis	SMED30030824	SMESG000079803.1 SMESG000019442.1 SMESG000037000.1	Contig5397	GPL15192	PMID:28434803 Rouhana et al., 2017
oocyte	SMED30030824	SMESG000019746.1	Contig23691	newmark_ests	PMID:28434803 Rouhana et al., 2017
vitelline gland	SMED30030824	SMESG000019746.1	Contig23691	newmark_ests	PMID:28434803 Rouhana et al., 2017
oocyte	SMED30030824	SMESG000019746.1	Contig23691	uc_Smed_v2	PMID:28434803 Rouhana et al., 2017
vitelline gland	SMED30030824	SMESG000019746.1	Contig23691	uc_Smed_v2	PMID:28434803 Rouhana et al., 2017
testis	SMED30030824	SMESG000019746.1	PL06015B2F05	ncbi_smed_ests	PMID:28434803 Rouhana et al., 2017
testis	SMED30030824	SMESG000019746.1	Contig5397	GPL15192	PMID:28434803 Rouhana et al., 2017
epidermis	SMED30030824	SMESG000019746.1	dd_Smed_v4_1065_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of ENTH domain-containing protein vs. Ensembl Human
Match: CLINT1 (clathrin interactor 1 [Source:HGNC Symbol;Acc:HGNC:23186])

HSP 1 Score: 188.734 bits (478), Expect = 2.273e-51
Identity = 99/164 (60.37%), Postives = 123/164 (75.00%), Query Frame = 1

Query:  109 KELADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISGSVNGHR 600
            +EL DK TN VMNY+E+E+KVR ATNDDPWGP GQ M EIA+ T  Y+   ++M MLW RM ++ K NWRR YKSLLLL+YL+RNGSER+V S +EHIYDLR LE+Y ++DE+GKDQGINIR K KEL+   +++ +L  ERKKA  N+ KY    S SV G R
Sbjct:    8 RELVDKATNVVMNYSEIESKVREATNDDPWGPSGQLMGEIAKATFMYEQFPELMNMLWSRMLKDNKKNWRRVYKSLLLLAYLIRNGSERVVTSAREHIYDLRSLENYHFVDEHGKDQGINIRQKVKELVEFAQDDDRLREERKKAKKNKDKYVGVSSDSVGGFR 171

[Close]

BLAST of ENTH domain-containing protein vs. Ensembl Human
Match: CLINT1 (clathrin interactor 1 [Source:HGNC Symbol;Acc:HGNC:23186])

HSP 1 Score: 188.734 bits (478), Expect = 2.688e-51
Identity = 99/164 (60.37%), Postives = 123/164 (75.00%), Query Frame = 1

Query:  109 KELADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISGSVNGHR 600
            +EL DK TN VMNY+E+E+KVR ATNDDPWGP GQ M EIA+ T  Y+   ++M MLW RM ++ K NWRR YKSLLLL+YL+RNGSER+V S +EHIYDLR LE+Y ++DE+GKDQGINIR K KEL+   +++ +L  ERKKA  N+ KY    S SV G R
Sbjct:    8 RELVDKATNVVMNYSEIESKVREATNDDPWGPSGQLMGEIAKATFMYEQFPELMNMLWSRMLKDNKKNWRRVYKSLLLLAYLIRNGSERVVTSAREHIYDLRSLENYHFVDEHGKDQGINIRQKVKELVEFAQDDDRLREERKKAKKNKDKYVGVSSDSVGGFR 171

[Close]

BLAST of ENTH domain-containing protein vs. Ensembl Human
Match: CLINT1 (clathrin interactor 1 [Source:HGNC Symbol;Acc:HGNC:23186])

HSP 1 Score: 174.481 bits (441), Expect = 2.837e-46
Identity = 92/153 (60.13%), Postives = 115/153 (75.16%), Query Frame = 1

Query:  142 MNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISGSVNGHR 600
            MNY+E+E+KVR ATNDDPWGP GQ M EIA+ T  Y+   ++M MLW RM ++ K NWRR YKSLLLL+YL+RNGSER+V S +EHIYDLR LE+Y ++DE+GKDQGINIR K KEL+   +++ +L  ERKKA  N+ KY    S SV G R
Sbjct:    1 MNYSEIESKVREATNDDPWGPSGQLMGEIAKATFMYEQFPELMNMLWSRMLKDNKKNWRRVYKSLLLLAYLIRNGSERVVTSAREHIYDLRSLENYHFVDEHGKDQGINIRQKVKELVEFAQDDDRLREERKKAKKNKDKYVGVSSDSVGGFR 153

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Query:  142 MNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISGSVNGHR 600
            MNY+E+E+KVR ATNDDPWGP GQ M EIA+ T  Y+   ++M MLW RM ++ K NWRR YKSLLLL+YL+RNGSER+V S +EHIYDLR LE+Y ++DE+GKDQGINIR K KEL+   +++ +L  ERKKA  N+ KY    S SV G R
Sbjct:    1 MNYSEIESKVREATNDDPWGPSGQLMGEIAKATFMYEQFPELMNMLWSRMLKDNKKNWRRVYKSLLLLAYLIRNGSERVVTSAREHIYDLRSLENYHFVDEHGKDQGINIRQKVKELVEFAQDDDRLREERKKAKKNKDKYVGVSSDSVGGFR 153

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BLAST of ENTH domain-containing protein vs. Ensembl Human
Match: EPN3 (epsin 3 [Source:HGNC Symbol;Acc:HGNC:18235])

HSP 1 Score: 143.28 bits (360), Expect = 9.060e-39
Identity = 87/204 (42.65%), Postives = 121/204 (59.31%), Query Frame = 1

Query:  115 LADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYK-AGI---SGSVNGHRRYWNSDDMKATERSTRERSCTPPSPSVNGSSRPPAKPP 714
            L  +V N V NY+E E KVR AT++DPWGP    M EIA+ T +    T+VMGMLWRR+    K NWR  YK+L LL YLL+ GSER+   C+E++Y ++ L+ +QYID +GKDQG+N+R K K+++ LL++E +L  ER  A   + +    GI   SG +   RRY   +D   +  S    +C  P+  V G     A  P
Sbjct:    6 LRRQVKNIVHNYSEAEIKVREATSNDPWGPPSSLMSEIADLTFNTVAFTEVMGMLWRRLNDSGK-NWRHVYKALTLLDYLLKTGSERVAHQCRENLYTIQTLKDFQYIDRDGKDQGVNVREKVKQVMALLKDEERLRQERTHALKTKERMALEGIGIGSGQLGFSRRY--GEDYSRSRGSPSSYNC--PASDVRGRGTAAAAGP 204

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BLAST of ENTH domain-containing protein vs. Ensembl Celegans
Match: rsd-3 (pep chromosome:WBcel235:X:11798505:11803656:1 gene:WBGene00004682.1 transcript:C34E11.1.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:rsd-3)

HSP 1 Score: 143.665 bits (361), Expect = 9.623e-37
Identity = 75/160 (46.88%), Postives = 110/160 (68.75%), Query Frame = 1

Query:  100 EMGKELADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTK--HYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATS-NRSKYKA 570
            E  +++ + + +A+MNY +    VR ATN+DPWGP G  M++I E+T+  + +    V   L++RM +  K  WRR YKSL+LL YLL+NGSER V   +E  Y+LR LESY+YIDE GKDQGINIRH+ K+++ ++ ++  L  ER+KA S ++SKY+ 
Sbjct:   23 EYVRKVTESMNDAIMNYPKAMMDVREATNEDPWGPTGPQMKKICEYTRSRYMEDFYNVYTPLFQRMLENNKDAWRRVYKSLILLDYLLKNGSERFVQEAREKAYELRRLESYKYIDEKGKDQGINIRHRVKQILEMMNDDELLQAERQKANSDDKSKYRG 182

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BLAST of ENTH domain-containing protein vs. Ensembl Celegans
Match: epn-1 (EPsiN (Endocytic protein) homolog [Source:UniProtKB/TrEMBL;Acc:Q9BI72])

HSP 1 Score: 122.865 bits (307), Expect = 9.142e-30
Identity = 61/163 (37.42%), Postives = 104/163 (63.80%), Query Frame = 1

Query:  124 KVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISGSVNGHRRYWN 612
            +V N   N+++ + KVR AT++DPWGP    M EIA+ T +    T++M ++W+R+    K NWR  YKSL+LL +L++ G E++   C+E+++ +  L+ +Q++++N +DQG+NIR K+K++  LL ++ +L NER +    R+K+K    G V    R  N
Sbjct:    9 QVKNVAYNFSDAQVKVREATSNDPWGPSTALMSEIADLTHNPMAFTEIMSIVWKRLNDSGK-NWRHVYKSLVLLDFLIKCGHEKVAQQCRENVFTIETLKDFQHVEDN-RDQGLNIREKAKQITSLLSDDERLKNERTRFILTRNKFKQNNPGPVGAESRRSN 169

[Close]

BLAST of ENTH domain-containing protein vs. Ensembl Celegans
Match: epn-1 (EPsiN (Endocytic protein) homolog [Source:UniProtKB/TrEMBL;Acc:Q9BI72])

HSP 1 Score: 122.865 bits (307), Expect = 9.714e-30
Identity = 61/163 (37.42%), Postives = 104/163 (63.80%), Query Frame = 1

Query:  124 KVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISGSVNGHRRYWN 612
            +V N   N+++ + KVR AT++DPWGP    M EIA+ T +    T++M ++W+R+    K NWR  YKSL+LL +L++ G E++   C+E+++ +  L+ +Q++++N +DQG+NIR K+K++  LL ++ +L NER +    R+K+K    G V    R  N
Sbjct:    9 QVKNVAYNFSDAQVKVREATSNDPWGPSTALMSEIADLTHNPMAFTEIMSIVWKRLNDSGK-NWRHVYKSLVLLDFLIKCGHEKVAQQCRENVFTIETLKDFQHVEDN-RDQGLNIREKAKQITSLLSDDERLKNERTRFILTRNKFKQNNPGPVGAESRRSN 169

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BLAST of ENTH domain-containing protein vs. Ensembl Fly
Match: lqfR (gene:FBgn0261279 transcript:FBtr0299515)

HSP 1 Score: 196.438 bits (498), Expect = 2.061e-54
Identity = 104/164 (63.41%), Postives = 126/164 (76.83%), Query Frame = 1

Query:  109 KELADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISGSVNGHR 600
            +ELADKVTN VMNYTE E KVR ATNDDPWGP G  MQE+A  T  Y+T  +VM MLW+RM Q+ K+NWRRTYKSLLLL+YL+RNGSER+V S +EHIYDLR LE+Y + DE GKDQGIN+RHK +ELI  ++++ +L  ERKKA  N+ KY  G+S    G R
Sbjct:   12 RELADKVTNVVMNYTETEGKVREATNDDPWGPTGPLMQELAYSTFSYETFPEVMSMLWKRMLQDNKTNWRRTYKSLLLLNYLVRNGSERVVTSSREHIYDLRSLENYTFTDEGGKDQGINVRHKVRELIDFIQDDDRLREERKKAKKNKDKY-IGMSSDAMGMR 174

[Close]

BLAST of ENTH domain-containing protein vs. Ensembl Fly
Match: lqfR (gene:FBgn0261279 transcript:FBtr0299516)

HSP 1 Score: 194.126 bits (492), Expect = 3.932e-52
Identity = 104/164 (63.41%), Postives = 126/164 (76.83%), Query Frame = 1

Query:  109 KELADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISGSVNGHR 600
            +ELADKVTN VMNYTE E KVR ATNDDPWGP G  MQE+A  T  Y+T  +VM MLW+RM Q+ K+NWRRTYKSLLLL+YL+RNGSER+V S +EHIYDLR LE+Y + DE GKDQGIN+RHK +ELI  ++++ +L  ERKKA  N+ KY  G+S    G R
Sbjct:   12 RELADKVTNVVMNYTETEGKVREATNDDPWGPTGPLMQELAYSTFSYETFPEVMSMLWKRMLQDNKTNWRRTYKSLLLLNYLVRNGSERVVTSSREHIYDLRSLENYTFTDEGGKDQGINVRHKVRELIDFIQDDDRLREERKKAKKNKDKY-IGMSSDAMGMR 174

[Close]

BLAST of ENTH domain-containing protein vs. Ensembl Fly
Match: lqf (gene:FBgn0028582 transcript:FBtr0076796)

HSP 1 Score: 127.102 bits (318), Expect = 3.080e-30
Identity = 64/156 (41.03%), Postives = 101/156 (64.74%), Query Frame = 1

Query:  115 LADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISG 582
            L   + N   NY++ + KVR AT++DPWGP    M EIAE T +    +++M M+W+R+    K NWR  YK+L+LL YL++ GSE++   CKE+I+ ++ L  + Y +E GKDQG ++R K+K+L+ LL+++ +L NER KA   + ++    SG
Sbjct:    8 LRRNIKNLAHNYSDAQVKVREATSNDPWGPSAAIMSEIAELTYNVVAFSEIMQMIWKRLNDHGK-NWRHVYKALILLEYLIKTGSEKVAQQCKENIFAIQTLREFVYFEE-GKDQGTHVREKAKQLVTLLKDDERLKNERVKAQKAKERFAQNPSG 161

[Close]

BLAST of ENTH domain-containing protein vs. Ensembl Fly
Match: lqf (gene:FBgn0028582 transcript:FBtr0076794)

HSP 1 Score: 127.102 bits (318), Expect = 3.080e-30
Identity = 64/156 (41.03%), Postives = 101/156 (64.74%), Query Frame = 1

Query:  115 LADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISG 582
            L   + N   NY++ + KVR AT++DPWGP    M EIAE T +    +++M M+W+R+    K NWR  YK+L+LL YL++ GSE++   CKE+I+ ++ L  + Y +E GKDQG ++R K+K+L+ LL+++ +L NER KA   + ++    SG
Sbjct:    8 LRRNIKNLAHNYSDAQVKVREATSNDPWGPSAAIMSEIAELTYNVVAFSEIMQMIWKRLNDHGK-NWRHVYKALILLEYLIKTGSEKVAQQCKENIFAIQTLREFVYFEE-GKDQGTHVREKAKQLVTLLKDDERLKNERVKAQKAKERFAQNPSG 161

[Close]

BLAST of ENTH domain-containing protein vs. Ensembl Fly
Match: lqf (gene:FBgn0028582 transcript:FBtr0076798)

HSP 1 Score: 127.102 bits (318), Expect = 3.169e-30
Identity = 64/156 (41.03%), Postives = 101/156 (64.74%), Query Frame = 1

Query:  115 LADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISG 582
            L   + N   NY++ + KVR AT++DPWGP    M EIAE T +    +++M M+W+R+    K NWR  YK+L+LL YL++ GSE++   CKE+I+ ++ L  + Y +E GKDQG ++R K+K+L+ LL+++ +L NER KA   + ++    SG
Sbjct:   15 LRRNIKNLAHNYSDAQVKVREATSNDPWGPSAAIMSEIAELTYNVVAFSEIMQMIWKRLNDHGK-NWRHVYKALILLEYLIKTGSEKVAQQCKENIFAIQTLREFVYFEE-GKDQGTHVREKAKQLVTLLKDDERLKNERVKAQKAKERFAQNPSG 168

[Close]

BLAST of ENTH domain-containing protein vs. Ensembl Zebrafish
Match: clint1a (clathrin interactor 1a [Source:ZFIN;Acc:ZDB-GENE-030131-2590])

HSP 1 Score: 200.675 bits (509), Expect = 8.077e-56
Identity = 100/164 (60.98%), Postives = 122/164 (74.39%), Query Frame = 1

Query:  109 KELADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISGSVNGHR 600
            +EL DK TN VMNYTE E+KVR ATNDDPWGP GQ M EIA  T  Y+   +VM MLW RM ++ K NWRR YKSLLLL+YL+RNGSER+V S +EH+YDLR +ESY  +DENGKDQG+N+R K KELI  ++++ +L  ERKKA  NR KY    S S++G R
Sbjct:    8 RELVDKATNVVMNYTETESKVREATNDDPWGPSGQLMGEIARCTFMYEQFPEVMNMLWTRMLKDNKKNWRRVYKSLLLLAYLIRNGSERVVTSAREHLYDLRSIESYHCVDENGKDQGVNVRQKVKELIEFVQDDDRLREERKKAKKNRDKYIGVSSDSMSGFR 171

[Close]

BLAST of ENTH domain-containing protein vs. Ensembl Zebrafish
Match: clint1a (clathrin interactor 1a [Source:ZFIN;Acc:ZDB-GENE-030131-2590])

HSP 1 Score: 191.815 bits (486), Expect = 1.322e-52
Identity = 96/157 (61.15%), Postives = 117/157 (74.52%), Query Frame = 1

Query:  130 TNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISGSVNGHR 600
            TN VMNYTE E+KVR ATNDDPWGP GQ M EIA  T  Y+   +VM MLW RM ++ K NWRR YKSLLLL+YL+RNGSER+V S +EH+YDLR +ESY  +DENGKDQG+N+R K KELI  ++++ +L  ERKKA  NR KY    S S++G R
Sbjct:   26 TNVVMNYTETESKVREATNDDPWGPSGQLMGEIARCTFMYEQFPEVMNMLWTRMLKDNKKNWRRVYKSLLLLAYLIRNGSERVVTSAREHLYDLRSIESYHCVDENGKDQGVNVRQKVKELIEFVQDDDRLREERKKAKKNRDKYIGVSSDSMSGFR 182

[Close]

BLAST of ENTH domain-containing protein vs. Ensembl Zebrafish
Match: clint1b (clathrin interactor 1b [Source:ZFIN;Acc:ZDB-GENE-111011-3])

HSP 1 Score: 169.474 bits (428), Expect = 7.861e-45
Identity = 92/160 (57.50%), Postives = 119/160 (74.38%), Query Frame = 1

Query:  142 MNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISGSVNGHRRYWNSDD 621
            MNY+E+E+KVR ATNDDPWGP GQ M EIA+ T  Y+   +VM MLW RM ++ K NWRR YK+LLLL+YL+RNGSER+V S +EHIYDLR LE+Y ++DENGKDQGIN+R K KE++  ++++ +L  ERKKA  N+ KY  G+S    G  R  NS +
Sbjct:    1 MNYSEIESKVREATNDDPWGPSGQLMGEIAKSTFMYEQFPEVMNMLWTRMLKDNKKNWRRVYKALLLLAYLIRNGSERVVTSAREHIYDLRSLENYHFVDENGKDQGINVRQKVKEMVEFVQDDDRLREERKKAKKNKDKY-IGVSSDNMGSSRQSNSGE 159

[Close]

BLAST of ENTH domain-containing protein vs. Ensembl Zebrafish
Match: epn2 (epsin 2 [Source:ZFIN;Acc:ZDB-GENE-071212-1])

HSP 1 Score: 141.739 bits (356), Expect = 2.287e-35
Identity = 70/160 (43.75%), Postives = 109/160 (68.12%), Query Frame = 1

Query:  124 KVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISGSVNGHRR 603
            ++ N V NY+E E KVR AT++DPWGP    M EIA+ T +    +++M M+W+R+    K NWR  YK+L LL YL++ GSER+ + CKE+I+ ++ L+ +QYID +GKDQGIN+R KSK+L+ LL+++ +L  ER +A   + +  A ++ SV  + +
Sbjct:    9 QMKNVVNNYSEPEKKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKRLNDHGK-NWRHVYKALTLLDYLIKTGSERVALQCKENIFAIQTLKDFQYIDRDGKDQGINVREKSKQLVVLLKDDDRLKGERSQALKTKERM-AQVATSVGSNNQ 166

[Close]

BLAST of ENTH domain-containing protein vs. Ensembl Zebrafish
Match: epn2 (epsin 2 [Source:ZFIN;Acc:ZDB-GENE-071212-1])

HSP 1 Score: 140.969 bits (354), Expect = 2.480e-35
Identity = 70/160 (43.75%), Postives = 109/160 (68.12%), Query Frame = 1

Query:  124 KVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISGSVNGHRR 603
            ++ N V NY+E E KVR AT++DPWGP    M EIA+ T +    +++M M+W+R+    K NWR  YK+L LL YL++ GSER+ + CKE+I+ ++ L+ +QYID +GKDQGIN+R KSK+L+ LL+++ +L  ER +A   + +  A ++ SV  + +
Sbjct:    9 QMKNVVNNYSEPEKKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKRLNDHGK-NWRHVYKALTLLDYLIKTGSERVALQCKENIFAIQTLKDFQYIDRDGKDQGINVREKSKQLVVLLKDDDRLKGERSQALKTKERM-AQVATSVGSNNQ 166

[Close]

BLAST of ENTH domain-containing protein vs. Ensembl Xenopus
Match: cyct (cytochrome c, testis [Source:Xenbase;Acc:XB-GENE-5931974])

HSP 1 Score: 188.734 bits (478), Expect = 2.229e-51
Identity = 98/166 (59.04%), Postives = 124/166 (74.70%), Query Frame = 1

Query:  109 KELADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISGSVNGHRRY 606
            +EL DK TN VMNY+E+E+KVR ATNDDPWGP GQ M EIA+ T  Y+    +M MLW RM ++ K NWRR YKS+LLL+YL+RNGSER+V S +EHIYDLR LE+Y ++DENGKDQGINIR K KE++  ++++ +L  ERKKA  N+ KY  G+S    G  RY
Sbjct:    8 RELVDKATNVVMNYSEIESKVREATNDDPWGPSGQLMGEIAKATFMYEQFPDLMNMLWTRMLKDNKKNWRRVYKSMLLLAYLIRNGSERVVTSAREHIYDLRSLENYHFVDENGKDQGINIRQKVKEMVEFIQDDDRLREERKKAKKNKDKY-IGVSSESAGGFRY 172

[Close]

BLAST of ENTH domain-containing protein vs. Ensembl Xenopus
Match: cyct (cytochrome c, testis [Source:Xenbase;Acc:XB-GENE-5931974])

HSP 1 Score: 179.874 bits (455), Expect = 2.364e-48
Identity = 94/159 (59.12%), Postives = 119/159 (74.84%), Query Frame = 1

Query:  130 TNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISGSVNGHRRY 606
            TN VMNY+E+E+KVR ATNDDPWGP GQ M EIA+ T  Y+    +M MLW RM ++ K NWRR YKS+LLL+YL+RNGSER+V S +EHIYDLR LE+Y ++DENGKDQGINIR K KE++  ++++ +L  ERKKA  N+ KY  G+S    G  RY
Sbjct:   20 TNVVMNYSEIESKVREATNDDPWGPSGQLMGEIAKATFMYEQFPDLMNMLWTRMLKDNKKNWRRVYKSMLLLAYLIRNGSERVVTSAREHIYDLRSLENYHFVDENGKDQGINIRQKVKEMVEFIQDDDRLREERKKAKKNKDKY-IGVSSESAGGFRY 177

[Close]

BLAST of ENTH domain-containing protein vs. Ensembl Xenopus
Match: cyct (cytochrome c, testis [Source:Xenbase;Acc:XB-GENE-5931974])

HSP 1 Score: 179.874 bits (455), Expect = 3.059e-48
Identity = 94/159 (59.12%), Postives = 119/159 (74.84%), Query Frame = 1

Query:  130 TNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISGSVNGHRRY 606
            TN VMNY+E+E+KVR ATNDDPWGP GQ M EIA+ T  Y+    +M MLW RM ++ K NWRR YKS+LLL+YL+RNGSER+V S +EHIYDLR LE+Y ++DENGKDQGINIR K KE++  ++++ +L  ERKKA  N+ KY  G+S    G  RY
Sbjct:   20 TNVVMNYSEIESKVREATNDDPWGPSGQLMGEIAKATFMYEQFPDLMNMLWTRMLKDNKKNWRRVYKSMLLLAYLIRNGSERVVTSAREHIYDLRSLENYHFVDENGKDQGINIRQKVKEMVEFIQDDDRLREERKKAKKNKDKY-IGVSSESAGGFRY 177

[Close]

BLAST of ENTH domain-containing protein vs. Ensembl Xenopus
Match: uvssa (UV stimulated scaffold protein A [Source:Xenbase;Acc:XB-GENE-5833232])

HSP 1 Score: 142.124 bits (357), Expect = 3.570e-35
Identity = 65/150 (43.33%), Postives = 101/150 (67.33%), Query Frame = 1

Query:  115 LADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKY 564
            L  ++ N V NY+E E KVR AT++DPWGP    M EIA+ T +    +++M M+W+R+    K NWR  YK++ L+ YL++ GSER+   CKE+IY ++ L+ +QY+D +GKDQG+N+R K+K+L+ LL+++ +L  ER  A   + K 
Sbjct:    6 LRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKRLNDHGK-NWRHVYKAMTLMEYLIKTGSERVAQQCKENIYAIQTLKDFQYVDRDGKDQGVNVREKAKQLVSLLKDDERLKEERAHALKTKEKL 154

[Close]

BLAST of ENTH domain-containing protein vs. Ensembl Xenopus
Match: uvssa (UV stimulated scaffold protein A [Source:Xenbase;Acc:XB-GENE-5833232])

HSP 1 Score: 141.739 bits (356), Expect = 4.301e-35
Identity = 65/150 (43.33%), Postives = 101/150 (67.33%), Query Frame = 1

Query:  115 LADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKY 564
            L  ++ N V NY+E E KVR AT++DPWGP    M EIA+ T +    +++M M+W+R+    K NWR  YK++ L+ YL++ GSER+   CKE+IY ++ L+ +QY+D +GKDQG+N+R K+K+L+ LL+++ +L  ER  A   + K 
Sbjct:    6 LRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKRLNDHGK-NWRHVYKAMTLMEYLIKTGSERVAQQCKENIYAIQTLKDFQYVDRDGKDQGVNVREKAKQLVSLLKDDERLKEERAHALKTKEKL 154

[Close]

BLAST of ENTH domain-containing protein vs. Ensembl Mouse
Match: Clint1 (clathrin interactor 1 [Source:MGI Symbol;Acc:MGI:2144243])

HSP 1 Score: 187.963 bits (476), Expect = 2.542e-51
Identity = 99/164 (60.37%), Postives = 123/164 (75.00%), Query Frame = 1

Query:  109 KELADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISGSVNGHR 600
            +EL DK TN VMNY+E+E+KVR ATNDDPWGP GQ M EIA+ T  Y+   ++M MLW RM ++ K NWRR YKSLLLL+YL+RNGSER+V S +EHIYDLR LE+Y ++DE+GKDQGINIR K KEL+   +++ +L  ERKKA  N+ KY    S SV G R
Sbjct:    8 RELVDKATNVVMNYSEIESKVREATNDDPWGPSGQLMGEIAKATFMYEQFPELMNMLWSRMLKDNKKNWRRVYKSLLLLAYLIRNGSERVVTSAREHIYDLRSLENYHFVDEHGKDQGINIRQKVKELVEFAQDDDRLREERKKAKKNKDKYVGVSSDSVGGFR 171

[Close]

BLAST of ENTH domain-containing protein vs. Ensembl Mouse
Match: Clint1 (clathrin interactor 1 [Source:MGI Symbol;Acc:MGI:2144243])

HSP 1 Score: 187.963 bits (476), Expect = 3.387e-51
Identity = 99/164 (60.37%), Postives = 123/164 (75.00%), Query Frame = 1

Query:  109 KELADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISGSVNGHR 600
            +EL DK TN VMNY+E+E+KVR ATNDDPWGP GQ M EIA+ T  Y+   ++M MLW RM ++ K NWRR YKSLLLL+YL+RNGSER+V S +EHIYDLR LE+Y ++DE+GKDQGINIR K KEL+   +++ +L  ERKKA  N+ KY    S SV G R
Sbjct:    8 RELVDKATNVVMNYSEIESKVREATNDDPWGPSGQLMGEIAKATFMYEQFPELMNMLWSRMLKDNKKNWRRVYKSLLLLAYLIRNGSERVVTSAREHIYDLRSLENYHFVDEHGKDQGINIRQKVKELVEFAQDDDRLREERKKAKKNKDKYVGVSSDSVGGFR 171

[Close]

BLAST of ENTH domain-containing protein vs. Ensembl Mouse
Match: Epn3 (epsin 3 [Source:MGI Symbol;Acc:MGI:1919139])

HSP 1 Score: 142.51 bits (358), Expect = 2.268e-35
Identity = 73/164 (44.51%), Postives = 104/164 (63.41%), Query Frame = 1

Query:  115 LADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISGSVNGHRRY 606
            L  +V N V NY+E E KVR AT++DPWGP    M EIA+ T +     +VMGM+WRR+    K NWR  YK+L LL YLL+ GSER+   C+E++Y ++ L+ +QYID +GKDQG+N+R K K+++ LL++E +L  ER  A   + +      G  +G   Y
Sbjct:    6 LRRQVKNIVHNYSEAEIKVREATSNDPWGPPSSLMSEIADLTFNTVAFAEVMGMVWRRLNDSGK-NWRHVYKALTLLDYLLKTGSERVAHQCRENLYTIQTLKDFQYIDRDGKDQGVNVREKVKQVMALLKDEERLRQERTHALKTKERMALEGMGIGSGQLGY 168

[Close]

BLAST of ENTH domain-containing protein vs. Ensembl Mouse
Match: Epn2 (epsin 2 [Source:MGI Symbol;Acc:MGI:1333766])

HSP 1 Score: 140.198 bits (352), Expect = 8.883e-35
Identity = 68/153 (44.44%), Postives = 103/153 (67.32%), Query Frame = 1

Query:  124 KVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISG 582
            ++ N V NY+E E KVR AT++DPWGP    M EIA+ T +    +++M M+W+R+    K NWR  YK+L LL YL++ GSER+   C+E+I+ ++ L+ +QYID +GKDQGIN+R KSK+L+ LL++E +L  ER +A   + +     +G
Sbjct:    9 QMKNIVNNYSEAEIKVREATSNDPWGPSSSLMTEIADLTYNVVAFSEIMSMVWKRLNDHGK-NWRHVYKALTLLDYLIKTGSERVAQQCRENIFAIQTLKDFQYIDRDGKDQGINVREKSKQLVALLKDEERLKVERVQALKTKERMAQVATG 160

[Close]

BLAST of ENTH domain-containing protein vs. Ensembl Mouse
Match: Epn2 (epsin 2 [Source:MGI Symbol;Acc:MGI:1333766])

HSP 1 Score: 139.813 bits (351), Expect = 9.779e-35
Identity = 68/153 (44.44%), Postives = 103/153 (67.32%), Query Frame = 1

Query:  124 KVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISG 582
            ++ N V NY+E E KVR AT++DPWGP    M EIA+ T +    +++M M+W+R+    K NWR  YK+L LL YL++ GSER+   C+E+I+ ++ L+ +QYID +GKDQGIN+R KSK+L+ LL++E +L  ER +A   + +     +G
Sbjct:    9 QMKNIVNNYSEAEIKVREATSNDPWGPSSSLMTEIADLTYNVVAFSEIMSMVWKRLNDHGK-NWRHVYKALTLLDYLIKTGSERVAQQCRENIFAIQTLKDFQYIDRDGKDQGINVREKSKQLVALLKDEERLKVERVQALKTKERMAQVATG 160

[Close]

BLAST of ENTH domain-containing protein vs. UniProt/SwissProt
Match: sp|Q14677|EPN4_HUMAN (Clathrin interactor 1 OS=Homo sapiens OX=9606 GN=CLINT1 PE=1 SV=1)

HSP 1 Score: 188.734 bits (478), Expect = 1.091e-50
Identity = 99/164 (60.37%), Postives = 123/164 (75.00%), Query Frame = 1

Query:  109 KELADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISGSVNGHR 600
            +EL DK TN VMNY+E+E+KVR ATNDDPWGP GQ M EIA+ T  Y+   ++M MLW RM ++ K NWRR YKSLLLL+YL+RNGSER+V S +EHIYDLR LE+Y ++DE+GKDQGINIR K KEL+   +++ +L  ERKKA  N+ KY    S SV G R
Sbjct:    8 RELVDKATNVVMNYSEIESKVREATNDDPWGPSGQLMGEIAKATFMYEQFPELMNMLWSRMLKDNKKNWRRVYKSLLLLAYLIRNGSERVVTSAREHIYDLRSLENYHFVDEHGKDQGINIRQKVKELVEFAQDDDRLREERKKAKKNKDKYVGVSSDSVGGFR 171

[Close]

BLAST of ENTH domain-containing protein vs. UniProt/SwissProt
Match: sp|A7Z035|EPN4_BOVIN (Clathrin interactor 1 OS=Bos taurus OX=9913 GN=CLINT1 PE=2 SV=1)

HSP 1 Score: 188.348 bits (477), Expect = 1.559e-50
Identity = 99/164 (60.37%), Postives = 123/164 (75.00%), Query Frame = 1

Query:  109 KELADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISGSVNGHR 600
            +EL DK TN VMNY+E+E+KVR ATNDDPWGP GQ M EIA+ T  Y+   ++M MLW RM ++ K NWRR YKSLLLL+YL+RNGSER+V S +EHIYDLR LE+Y ++DE+GKDQGINIR K KEL+   +++ +L  ERKKA  N+ KY    S SV G R
Sbjct:    8 RELVDKATNVVMNYSEIESKVREATNDDPWGPSGQLMGEIAKATFMYEQFPELMNMLWSRMLKDNKKNWRRVYKSLLLLAYLIRNGSERVVTSAREHIYDLRSLENYHFVDEHGKDQGINIRQKVKELVEFAQDDDRLREERKKAKKNKDKYVGVSSDSVGGFR 171

[Close]

BLAST of ENTH domain-containing protein vs. UniProt/SwissProt
Match: sp|Q99KN9|EPN4_MOUSE (Clathrin interactor 1 OS=Mus musculus OX=10090 GN=Clint1 PE=1 SV=2)

HSP 1 Score: 179.489 bits (454), Expect = 2.450e-47
Identity = 95/157 (60.51%), Postives = 118/157 (75.16%), Query Frame = 1

Query:  130 TNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISGSVNGHR 600
            TN VMNY+E+E+KVR ATNDDPWGP GQ M EIA+ T  Y+   ++M MLW RM ++ K NWRR YKSLLLL+YL+RNGSER+V S +EHIYDLR LE+Y ++DE+GKDQGINIR K KEL+   +++ +L  ERKKA  N+ KY    S SV G R
Sbjct:   23 TNVVMNYSEIESKVREATNDDPWGPSGQLMGEIAKATFMYEQFPELMNMLWSRMLKDNKKNWRRVYKSLLLLAYLIRNGSERVVTSAREHIYDLRSLENYHFVDEHGKDQGINIRQKVKELVEFAQDDDRLREERKKAKKNKDKYVGVSSDSVGGFR 179

[Close]

BLAST of ENTH domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9H201|EPN3_HUMAN (Epsin-3 OS=Homo sapiens OX=9606 GN=EPN3 PE=2 SV=1)

HSP 1 Score: 147.517 bits (371), Expect = 3.086e-36
Identity = 79/168 (47.02%), Postives = 109/168 (64.88%), Query Frame = 1

Query:  115 LADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYK-AGI---SGSVNGHRRY 606
            L  +V N V NY+E E KVR AT++DPWGP    M EIA+ T +    T+VMGMLWRR+    K NWR  YK+L LL YLL+ GSER+   C+E++Y ++ L+ +QYID +GKDQG+N+R K K+++ LL++E +L  ER  A   + +    GI   SG +   RRY
Sbjct:    6 LRRQVKNIVHNYSEAEIKVREATSNDPWGPPSSLMSEIADLTFNTVAFTEVMGMLWRRLNDSGK-NWRHVYKALTLLDYLLKTGSERVAHQCRENLYTIQTLKDFQYIDRDGKDQGVNVREKVKQVMALLKDEERLRQERTHALKTKERMALEGIGIGSGQLGFSRRY 172

[Close]

BLAST of ENTH domain-containing protein vs. UniProt/SwissProt
Match: sp|Q91W69|EPN3_MOUSE (Epsin-3 OS=Mus musculus OX=10090 GN=Epn3 PE=1 SV=1)

HSP 1 Score: 142.51 bits (358), Expect = 1.586e-34
Identity = 73/164 (44.51%), Postives = 104/164 (63.41%), Query Frame = 1

Query:  115 LADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISGSVNGHRRY 606
            L  +V N V NY+E E KVR AT++DPWGP    M EIA+ T +     +VMGM+WRR+    K NWR  YK+L LL YLL+ GSER+   C+E++Y ++ L+ +QYID +GKDQG+N+R K K+++ LL++E +L  ER  A   + +      G  +G   Y
Sbjct:    6 LRRQVKNIVHNYSEAEIKVREATSNDPWGPPSSLMSEIADLTFNTVAFAEVMGMVWRRLNDSGK-NWRHVYKALTLLDYLLKTGSERVAHQCRENLYTIQTLKDFQYIDRDGKDQGVNVREKVKQVMALLKDEERLRQERTHALKTKERMALEGMGIGSGQLGY 168

[Close]

BLAST of ENTH domain-containing protein vs. TrEMBL
Match: A0A1I8IYT0 (ENTH domain-containing protein OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 212.616 bits (540), Expect = 6.154e-58
Identity = 103/161 (63.98%), Postives = 128/161 (79.50%), Query Frame = 1

Query:   82 MLREVFEMGKELADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKY 564
            MLREVF  GK+LA+KVTN VMNYTE+E KVR ATND+ WGPHG+ MQE+A  T  Y+   +VMGMLW+RM  + K NWRR YKSLLLL+YL+R+GSER+V S +EHIYDLR LESYQ++DE GKD+GINIRHK+ EL+  ++++ +L  ERK A  NR KY
Sbjct:    1 MLREVFSKGKDLAEKVTNVVMNYTELEGKVREATNDEAWGPHGEVMQELANATMSYEQFPEVMGMLWKRMLFDNKRNWRRVYKSLLLLTYLIRHGSERVVTSAREHIYDLRGLESYQFVDERGKDEGINIRHKAHELVEFIQDDDKLREERKAARKNRDKY 161

[Close]

BLAST of ENTH domain-containing protein vs. TrEMBL
Match: A0A3M7SRR7 (Clathrin interactor 1-like (Fragment) OS=Brachionus plicatilis OX=10195 GN=BpHYR1_041562 PE=4 SV=1)

HSP 1 Score: 204.142 bits (518), Expect = 2.248e-57
Identity = 103/162 (63.58%), Postives = 128/162 (79.01%), Query Frame = 1

Query:  109 KELADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISGSVNG 594
            KEL DKVTN VMNYTEVE KVR ATND+ WGPHG  MQEIA++T  Y+  ++VMGMLW+RMFQE K NWR  YKSLLLL+YLL+NGSE+ V S +EH+YDLR LE++ Y+DENGKDQGIN+R K KE+I L++++ ++  ERKKA  NR K+ +G S S  G
Sbjct:   14 KELKDKVTNVVMNYTEVEVKVREATNDEAWGPHGTLMQEIAQYTLTYEHYSEVMGMLWKRMFQENKENWRIAYKSLLLLTYLLKNGSEKCVTSAREHLYDLRSLETFAYVDENGKDQGINVRIKVKEIIELVQDDERIREERKKAKKNREKF-SGYSTSSMG 174

[Close]

BLAST of ENTH domain-containing protein vs. TrEMBL
Match: A0A267E6W1 (ENTH domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig034596g1 PE=4 SV=1)

HSP 1 Score: 213.386 bits (542), Expect = 2.420e-57
Identity = 103/161 (63.98%), Postives = 128/161 (79.50%), Query Frame = 1

Query:   82 MLREVFEMGKELADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKY 564
            MLREVF  GK+LA+KVTN VMNYTE+E KVR ATND+ WGPHG+ MQE+A  T  Y+   +VMGMLW+RM  + K NWRR YKSLLLL+YL+R+GSER+V S +EHIYDLR LESYQ++DE GKD+GINIRHK+ EL+  ++++ +L  ERK A  NR KY
Sbjct:    1 MLREVFSKGKDLAEKVTNVVMNYTELEGKVREATNDEAWGPHGEVMQELANATMSYEQFPEVMGMLWKRMLFDNKRNWRRVYKSLLLLTYLIRHGSERVVTSAREHIYDLRGLESYQFVDERGKDEGINIRHKAHELVEFIQDDDKLREERKAARKNRDKY 161

[Close]

BLAST of ENTH domain-containing protein vs. TrEMBL
Match: A7RIC8 (Predicted protein (Fragment) OS=Nematostella vectensis OX=45351 GN=v1g82777 PE=4 SV=1)

HSP 1 Score: 194.512 bits (493), Expect = 5.070e-55
Identity = 100/171 (58.48%), Postives = 131/171 (76.61%), Query Frame = 1

Query:  109 KELADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISGS--VNGHRRYWNS 615
            +E++DKVTN VMNY+EVEAKVR ATNDD WGPHG  MQEIA++T  Y+   +VM MLW+RM QE K  WRR YKSLLLL YLL+NGS+R+V + ++HIYD+R LE++ + DENGKDQGIN+RHK KELI L++++ ++ +ERK+A  NR KY  G+S     + H   WN+
Sbjct:    8 REISDKVTNVVMNYSEVEAKVREATNDDTWGPHGSLMQEIAKYTFTYEHFPEVMSMLWKRMLQEPKKYWRRIYKSLLLLGYLLKNGSDRVVTNARDHIYDMRQLENFHHTDENGKDQGINVRHKVKELIELVQDDDRIRSERKRAKKNRDKY-TGVSSENYRDSHYSKWNN 177

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BLAST of ENTH domain-containing protein vs. TrEMBL
Match: K1Q680 (Clathrin interactor 1 OS=Crassostrea gigas OX=29159 GN=CGI_10022178 PE=4 SV=1)

HSP 1 Score: 206.068 bits (523), Expect = 2.212e-54
Identity = 102/158 (64.56%), Postives = 125/158 (79.11%), Query Frame = 1

Query:  109 KELADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISG 582
            +E+ DKVTN VMNYTEVE KVR ATNDD WGPHGQ MQEIA +T  Y+   +VMGMLW+RM  + K NWRRTYKSLLLL+YL+RNGSE+ V SC+EH+YDLR LESY + DE GKDQG+N+R K+KEL+  ++++ +L  ERKKA  NR KY  G+SG
Sbjct:    5 REITDKVTNVVMNYTEVETKVREATNDDAWGPHGQIMQEIARYTFTYEHFPEVMGMLWKRMLHDNKKNWRRTYKSLLLLAYLVRNGSEKSVTSCREHLYDLRGLESYTFTDELGKDQGLNVRTKAKELVDFIQDDERLREERKKAKKNRDKY-IGMSG 161

[Close]

BLAST of ENTH domain-containing protein vs. Ensembl Cavefish
Match: clint1a (clathrin interactor 1a [Source:ZFIN;Acc:ZDB-GENE-030131-2590])

HSP 1 Score: 189.889 bits (481), Expect = 4.479e-52
Identity = 96/167 (57.49%), Postives = 123/167 (73.65%), Query Frame = 1

Query:  130 TNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISGSVNGHRRYWNSDDMKA 630
            TN VMNYTE+E+KVR ATNDDPWGP GQ M EIA+ T  Y+   +VM MLW RM ++ K NWRR YKSLLLL+YL+RNGSER+V S +EH+YDLR +ESY  IDENGKDQG+N+R K KE++  ++++ +L  ERKKA  NR KY  G+S    G  +Y +  D ++
Sbjct:   21 TNVVMNYTEMESKVREATNDDPWGPSGQLMGEIAKATFMYEQFPEVMNMLWYRMLKDNKKNWRRVYKSLLLLAYLIRNGSERVVTSAREHLYDLRSIESYHCIDENGKDQGVNVRQKVKEMVEFVQDDDRLREERKKAKKNRDKY-IGVSSDSMGGFKYGDKYDSRS 186

[Close]

BLAST of ENTH domain-containing protein vs. Ensembl Cavefish
Match: epn3a (epsin 3 [Source:NCBI gene;Acc:103029089])

HSP 1 Score: 147.517 bits (371), Expect = 2.866e-37
Identity = 77/158 (48.73%), Postives = 105/158 (66.46%), Query Frame = 1

Query:  115 LADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISGSV 588
            L   V N V NYTE E KVR AT++DPWGP    M EIA+ T +    T+VMGM+W+R+    K NWR  YK+L LL YLL+ GSER+   C+E+IY ++ L  +QYID +G+DQG+N+R K+K+L+ LL +E +L  ER +A   R +  AG  GS+
Sbjct:    6 LRRSVKNIVNNYTEAEIKVREATSNDPWGPPSSLMMEIADLTFNVVAFTEVMGMVWKRLNDHGK-NWRHVYKALTLLEYLLKAGSERVAQQCRENIYAIQTLRDFQYIDRDGQDQGVNVREKAKQLVSLLRDEDRLKQERSQAHKTRERM-AGAYGSL 161

[Close]

BLAST of ENTH domain-containing protein vs. Ensembl Cavefish
Match: epn3a (epsin 3 [Source:NCBI gene;Acc:103029089])

HSP 1 Score: 147.517 bits (371), Expect = 3.428e-37
Identity = 77/158 (48.73%), Postives = 105/158 (66.46%), Query Frame = 1

Query:  115 LADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISGSV 588
            L   V N V NYTE E KVR AT++DPWGP    M EIA+ T +    T+VMGM+W+R+    K NWR  YK+L LL YLL+ GSER+   C+E+IY ++ L  +QYID +G+DQG+N+R K+K+L+ LL +E +L  ER +A   R +  AG  GS+
Sbjct:    6 LRRSVKNIVNNYTEAEIKVREATSNDPWGPPSSLMMEIADLTFNVVAFTEVMGMVWKRLNDHGK-NWRHVYKALTLLEYLLKAGSERVAQQCRENIYAIQTLRDFQYIDRDGQDQGVNVREKAKQLVSLLRDEDRLKQERSQAHKTRERM-AGAYGSL 161

[Close]

Query:  115 LADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISGSV 588
            L   V N V NYTE E KVR AT++DPWGP    M EIA+ T +    T+VMGM+W+R+    K NWR  YK+L LL YLL+ GSER+   C+E+IY ++ L  +QYID +G+DQG+N+R K+K+L+ LL +E +L  ER +A   R +  AG  GS+
Sbjct:    6 LRRSVKNIVNNYTEAEIKVREATSNDPWGPPSSLMMEIADLTFNVVAFTEVMGMVWKRLNDHGK-NWRHVYKALTLLEYLLKAGSERVAQQCRENIYAIQTLRDFQYIDRDGQDQGVNVREKAKQLVSLLRDEDRLKQERSQAHKTRERM-AGAYGSL 161

[Close]

BLAST of ENTH domain-containing protein vs. Ensembl Cavefish
Match: epn2 (epsin 2 [Source:ZFIN;Acc:ZDB-GENE-071212-1])

HSP 1 Score: 141.739 bits (356), Expect = 1.216e-35
Identity = 68/160 (42.50%), Postives = 109/160 (68.12%), Query Frame = 1

Query:  124 KVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISGSVNGHRR 603
            ++ N V NY+E E KVR AT++DPWGP    M EI++ T +    +++M M+W+R+  +   NWR  YK+L LL YL++ GSER+ + CKE+I+ ++ L+ +QYID +GKDQGIN+R KSK+L+ LL+++ +L  ER +A   + +  A ++ SV  + +
Sbjct:    9 QMKNVVNNYSEAEKKVREATSNDPWGPSSSLMSEISDLTYNVVAFSEIMSMIWKRL-NDHGKNWRHVYKALTLLDYLIKTGSERVALQCKENIFAIQTLKDFQYIDRDGKDQGINVREKSKQLVVLLKDDDRLKGERSQALKTKERM-AQVATSVGSNHQ 166

[Close]

BLAST of ENTH domain-containing protein vs. Ensembl Sea Lamprey
Match: clint1a (clathrin interactor 1a [Source:ZFIN;Acc:ZDB-GENE-030131-2590])

HSP 1 Score: 188.348 bits (477), Expect = 4.248e-52
Identity = 95/170 (55.88%), Postives = 124/170 (72.94%), Query Frame = 1

Query:  109 KELADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISGSVNGHRRYWNSD 618
            K L D  TN VMNYTE+EAKVR ATND+PWGP G+ M EIA+ T  Y+   +VM MLW RM +E K+NWRR YK LLLL+YLLRNGSER+V S +EH+YDLR LE Y ++DENGKDQG+N+R K KE+I  ++++ ++  ERKKA  +R KY    S +  G+   ++S+
Sbjct:    7 KALVDLKTNIVMNYTEMEAKVREATNDEPWGPSGKLMGEIAKATFMYELFPEVMNMLWARMLRENKNNWRRAYKGLLLLTYLLRNGSERVVTSAREHLYDLRSLEDYHFVDENGKDQGVNVRQKVKEMIDFVQDDERVREERKKAKKHRDKYIGVSSDTRFGYNDRYDSE 176

[Close]

BLAST of ENTH domain-containing protein vs. Ensembl Sea Lamprey
Match: epn2 (epsin 2 [Source:ZFIN;Acc:ZDB-GENE-071212-1])

HSP 1 Score: 143.28 bits (360), Expect = 1.326e-36
Identity = 68/156 (43.59%), Postives = 104/156 (66.67%), Query Frame = 1

Query:  115 LADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISG 582
            L  ++ N V N++E E KVR AT++DPWGP    M EIA+ T +    +++M M+W+R+    K NWR  YK+L LL YL++ GSER+   CKE+I+ ++ L+ +QY+D +GKDQG+N+R KSK+L+ LL +E +L  ER+ A   + +   G +G
Sbjct:    6 LRRQMKNIVNNFSEAEVKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKRLNDHGK-NWRHVYKALTLLDYLIKTGSERVAQQCKENIFAIQTLKDFQYVDRDGKDQGVNVREKSKQLVALLRDEDRLRGEREHALKTKERLAQGATG 160

[Close]

BLAST of ENTH domain-containing protein vs. Ensembl Yeast
Match: ENT3 (Protein containing an N-terminal epsin-like domain; involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p [Source:SGD;Acc:S000003886])

HSP 1 Score: 131.724 bits (330), Expect = 8.781e-34
Identity = 70/165 (42.42%), Postives = 106/165 (64.24%), Query Frame = 1

Query:  106 GKELADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYK--AGISGSVNG 594
             K+   K  N V NYTE+E KVR ATN++PWG     M +I++ T ++    +++ M++RR  ++  S WR+ YK+L LL YL+++GSER +   +  I  +R+LE++ YID  G+DQGIN+R + K LI LL +++++  ERKKA     KYK  AG S S +G
Sbjct:   15 AKKYFRKAQNVVFNYTEMEGKVREATNNEPWGASSTLMDQISQGTYNFREREEILSMIFRRFTEKAGSEWRQIYKALQLLDYLIKHGSERFIDDTRNSINLIRILETFHYIDSQGRDQGINVRTRVKALIELLSDDNKIRAERKKARETAKKYKGVAGGSASADG 179

[Close]

BLAST of ENTH domain-containing protein vs. Ensembl Yeast
Match: ENT1 (Epsin-like protein involved in endocytosis and actin patch assembly; functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus; relocalizes from bud neck to cytoplasm upon DNA replication stress; ENT1 has a paralog, ENT2, that arose from the whole genome duplication [Source:SGD;Acc:S000002320])

HSP 1 Score: 77.0258 bits (188), Expect = 1.698e-15
Identity = 50/146 (34.25%), Postives = 85/146 (58.22%), Query Frame = 1

Query:  103 MGKELADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDT--LTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNER 534
            M K+      N V  Y+  +  VR AT++D        + E+AE  K YD+    ++M ML +R+  ++   WR   K+L ++ YL+R GSE  V+ C+E++Y ++ L+ +++ D+ G DQG  +R K+KEL  LL ++ +L+ ER
Sbjct:    1 MSKQFVRSAKNLVKGYSSTQVLVRNATSNDNHQVSKDSLIELAE--KSYDSADFFEIMDMLDKRL-NDKGKYWRHIAKALTVIDYLIRFGSENCVLWCRENLYIIKTLKEFRHEDDEGIDQGQIVRVKAKELTALLSDDERLNEER 143

[Close]

BLAST of ENTH domain-containing protein vs. Ensembl Yeast
Match: ENT2 (Epsin-like protein required for endocytosis and actin patch assembly; functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus; ENT2 has a paralog, ENT1, that arose from the whole genome duplication [Source:SGD;Acc:S000004196])

HSP 1 Score: 75.8702 bits (185), Expect = 6.019e-15
Identity = 50/146 (34.25%), Postives = 85/146 (58.22%), Query Frame = 1

Query:  103 MGKELADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLT--QVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNER 534
            M K+      N +  Y+  +  VR AT +D   P    + ++A+  + YD++   ++M ML +R+  ++   WR   KSL +L YL+R GSE  V+ C+E+ Y ++ L  +++ +E+G D+G  IR K+KEL+ LL +E +L  ER
Sbjct:    1 MSKQFVRSAKNMMKGYSSTQVLVRDATANDSRTPSIDTLDDLAQ--RSYDSVDFFEIMDMLDKRL-NDKGKYWRHVAKSLTVLDYLVRFGSENCVLWCRENFYVIKTLREFRHENESGFDEGQIIRVKAKELVSLLNDEERLREER 143

[Close]

BLAST of ENTH domain-containing protein vs. Ensembl Nematostella
Match: EDO48788 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RIC8])

HSP 1 Score: 194.512 bits (493), Expect = 6.866e-59
Identity = 100/171 (58.48%), Postives = 131/171 (76.61%), Query Frame = 1

Query:  109 KELADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISGS--VNGHRRYWNS 615
            +E++DKVTN VMNY+EVEAKVR ATNDD WGPHG  MQEIA++T  Y+   +VM MLW+RM QE K  WRR YKSLLLL YLL+NGS+R+V + ++HIYD+R LE++ + DENGKDQGIN+RHK KELI L++++ ++ +ERK+A  NR KY  G+S     + H   WN+
Sbjct:    8 REISDKVTNVVMNYSEVEAKVREATNDDTWGPHGSLMQEIAKYTFTYEHFPEVMSMLWKRMLQEPKKYWRRIYKSLLLLGYLLKNGSDRVVTNARDHIYDMRQLENFHHTDENGKDQGINVRHKVKELIELVQDDDRIRSERKRAKKNRDKY-TGVSSENYRDSHYSKWNN 177

[Close]

BLAST of ENTH domain-containing protein vs. Ensembl Nematostella
Match: EDO36992 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SH59])

HSP 1 Score: 133.65 bits (335), Expect = 1.159e-36
Identity = 63/147 (42.86%), Postives = 105/147 (71.43%), Query Frame = 1

Query:  124 KVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKY 564
            ++ N V NY+  E KVR AT++DPWGP    M EIA+ T +    +++M M+WRR+  +   NWR  YKSL+LL Y+++ GSER+   C+E+I+ ++ L+ +Q+ID++GKDQG+N+R K+K+L+ LL++E +L +ER++A   + ++
Sbjct:    6 QLKNVVNNYSNSEVKVREATSNDPWGPSSSLMSEIADATYNVVAFSEIMAMIWRRL-NDHGKNWRHVYKSLVLLDYIIKTGSERVAQQCRENIFVIQTLKDFQFIDKDGKDQGMNVREKAKQLVALLKDEERLKSERQRALKAKERF 151

[Close]

BLAST of ENTH domain-containing protein vs. Ensembl Medaka
Match: clint1a (clathrin interactor 1 [Source:NCBI gene;Acc:101169791])

HSP 1 Score: 190.66 bits (483), Expect = 1.175e-52
Identity = 98/166 (59.04%), Postives = 125/166 (75.30%), Query Frame = 1

Query:  109 KELADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISGSVNGHRRY 606
            +EL DK TN VMNY+EVE+KVR ATNDDPWGP GQ M EI+  T  Y+   +VM MLW RM ++ K NWRR YKSLLLL++L+RNGSER+V S +EH+YDLR LESY ++DENGKDQGIN+R K KE++  ++++ +L  ERKKA  N+ KY  G+S    G+R Y
Sbjct:    8 RELVDKATNVVMNYSEVESKVREATNDDPWGPSGQMMTEISRATFMYEQFPEVMNMLWARMLRDNKKNWRRVYKSLLLLAHLIRNGSERVVTSAREHLYDLRSLESYHFVDENGKDQGINVRQKVKEMVDFIQDDDRLREERKKAKKNKDKY-IGVSSDSMGYRGY 172

[Close]

BLAST of ENTH domain-containing protein vs. Ensembl Medaka
Match: CLINT1 (clathrin interactor 1 [Source:NCBI gene;Acc:101160502])

HSP 1 Score: 180.644 bits (457), Expect = 1.380e-48
Identity = 94/152 (61.84%), Postives = 119/152 (78.29%), Query Frame = 1

Query:  109 KELADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKY 564
            +EL DK TN VMNY+E+E+KVR ATNDDPWGP GQ M EIA+ T  Y+   +VM MLW RM ++ K NWRR YK+LLLL+YL+RNGSER+V S +EHIYDLR LE+Y +IDENGKDQGIN+R K KE++  ++++ +L  ERKKA  N+ KY
Sbjct:    8 RELVDKATNVVMNYSEIESKVREATNDDPWGPSGQLMGEIAKSTFMYEQFPEVMNMLWTRMLKDNKKNWRRVYKALLLLAYLIRNGSERVVTSSREHIYDLRSLENYNFIDENGKDQGINVRQKVKEMVEFIQDDDRLREERKKAKKNKDKY 159

[Close]

BLAST of ENTH domain-containing protein vs. Ensembl Medaka
Match: CLINT1 (clathrin interactor 1 [Source:NCBI gene;Acc:101160502])

HSP 1 Score: 179.874 bits (455), Expect = 1.411e-48
Identity = 94/152 (61.84%), Postives = 119/152 (78.29%), Query Frame = 1

Query:  109 KELADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKY 564
            +EL DK TN VMNY+E+E+KVR ATNDDPWGP GQ M EIA+ T  Y+   +VM MLW RM ++ K NWRR YK+LLLL+YL+RNGSER+V S +EHIYDLR LE+Y +IDENGKDQGIN+R K KE++  ++++ +L  ERKKA  N+ KY
Sbjct:    8 RELVDKATNVVMNYSEIESKVREATNDDPWGPSGQLMGEIAKSTFMYEQFPEVMNMLWTRMLKDNKKNWRRVYKALLLLAYLIRNGSERVVTSSREHIYDLRSLENYNFIDENGKDQGINVRQKVKEMVEFIQDDDRLREERKKAKKNKDKY 159

[Close]

BLAST of ENTH domain-containing protein vs. Ensembl Medaka
Match: epn2 (epsin 2 [Source:NCBI gene;Acc:101161060])

HSP 1 Score: 141.739 bits (356), Expect = 2.021e-35
Identity = 67/154 (43.51%), Postives = 105/154 (68.18%), Query Frame = 1

Query:  124 KVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISGS 585
            ++ N V NY++ E KVR AT++DPWGP    M E+A+ T +    +++M M+W+R+    K NWR  YK+L LL YL++ GSER+ + CKE+I+ ++ L+ +QY+D +GKDQGIN+R KSK+L+ LL++E +L  ER +A   + +     +GS
Sbjct:    8 QMKNMVNNYSDAEKKVREATSNDPWGPSSSLMSEVADLTYNVVAFSEIMNMIWKRLNDHGK-NWRHVYKALTLLDYLIKTGSERVALQCKENIFAIQTLKDFQYVDRDGKDQGINVREKSKQLVVLLKDEERLKAERSQALKTKERMAQVSTGS 160

[Close]

BLAST of ENTH domain-containing protein vs. Ensembl Medaka
Match: epn1 (epsin-1 [Source:NCBI gene;Acc:101167232])

HSP 1 Score: 140.969 bits (354), Expect = 4.245e-35
Identity = 67/149 (44.97%), Postives = 101/149 (67.79%), Query Frame = 1

Query:  115 LADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSK 561
            L  +V N V NY+E E KVR AT++DPWGP    M EIA+ T +    +++M M+W+R+    K NWR  YK++ L+ YL++ GSER+   C+E+IY ++ L+ +QYID +GKDQG+N+R K+K+L+ LL++E +L  ER  A   + K
Sbjct:    6 LRRQVKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMVWKRLNDHGK-NWRHVYKAMTLMEYLIKTGSERVAQQCRENIYAVQTLKDFQYIDRDGKDQGLNVREKAKQLVTLLKDEEKLREERIHALKTKEK 153

[Close]

BLAST of ENTH domain-containing protein vs. Planmine SMEST
Match: SMESG000019746.1 (SMESG000019746.1)

HSP 1 Score: 866.685 bits (2238), Expect = 0.000e+0
Identity = 473/476 (99.37%), Postives = 473/476 (99.37%), Query Frame = 1

Query:   82 MLREVFEMGKELADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISGSVNGHRRYWNSDDMKATERSTRERSCTPPSPSVNGSSRPPAKPPVDLKPVAVVSKPAEPIADLLDLNVPMADSTNLPPLNHCANNAADTSFDPFNLGNEHREFXXXXXXXXXXXXXXXXXXRYSDDFDSFVSAAPPVPLPTSNLADLDLVFGNFXXXXXXXXXXXXPVALGTTGRPTLITQTPMTPKAISVATDNGKSDKMIIGSTWSDVGGINISLDLLSNRGQKATHSVTSSKSXXXXXXXXVFNSNNDSNKIYSNSRKQPFDSPKNHPHQSRNVAANEKLSNANVSFGQVNHSSANQFVAFNDLLQ 1509
            MLREVFEMGKELADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKSLLLLSYLLRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISGSVNGHRRYWNSDDMKATERSTRERSCTPPSPSVNGSSRPPAKPPVDLKPVAVVSKPAEPIADLLDLNVPMADSTNLPPLNHCANNAADTSFDPFNLGNEHREFTVPPVPSNPTSPTSPCNPRYSDDFDSFVSAA PVPLPTSNLADLDLVFGNFIDSSSNNDISNNPVALGTTGRPTLITQTPMTP AI VATDNGKSDKMIIGSTWSDVGGINISLDLLSNRGQKATHSVTSSKSLNQLQQQNVFNSNNDSNKIYSNSRKQPFDSPKNHPHQSRNVAANEKLSNANVSFGQVNHSSANQFVAFNDLLQ
Sbjct:    1 MLREVFEMGKELADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKSLLLLSYLLRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISGSVNGHRRYWNSDDMKATERSTRERSCTPPSPSVNGSSRPPAKPPVDLKPVAVVSKPAEPIADLLDLNVPMADSTNLPPLNHCANNAADTSFDPFNLGNEHREFTVPPVPSNPTSPTSPCNPRYSDDFDSFVSAALPVPLPTSNLADLDLVFGNFIDSSSNNDISNNPVALGTTGRPTLITQTPMTPNAIPVATDNGKSDKMIIGSTWSDVGGINISLDLLSNRGQKATHSVTSSKSLNQLQQQNVFNSNNDSNKIYSNSRKQPFDSPKNHPHQSRNVAANEKLSNANVSFGQVNHSSANQFVAFNDLLQ 476

[Close]

BLAST of ENTH domain-containing protein vs. Planmine SMEST
Match: SMESG000032527.1 (SMESG000032527.1)

HSP 1 Score: 131.339 bits (329), Expect = 1.071e-32
Identity = 73/156 (46.79%), Postives = 105/156 (67.31%), Query Frame = 1

Query:   82 MLREVFEMGKELADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATS 549
            ML  V   GK++A+K+TN  +N +E+E K++ ATNDD WGP+G  M+EIA+ T     L +VM  LW R+F E+  N RRTYK L+LL+YL+ NGSE I  SC+ H+ D++ L+S  YID +G    + IR K+ ++  LL +  +LS+ERK+A S
Sbjct:    1 MLSNVINAGKDIANKLTNKFLNLSEIEVKIKTATNDDNWGPNGSLMREIADETFSTTNLQEVMTFLWYRIFTEKPPNNRRTYKGLVLLTYLIVNGSELIAASCRAHLGDIKKLQS--YIDGHGV-ADVAIRRKASDICDLLSDSQRLSDERKRAKS 153

[Close]

BLAST of ENTH domain-containing protein vs. Planmine SMEST
Match: SMESG000032527.1 (SMESG000032527.1)

HSP 1 Score: 131.339 bits (329), Expect = 1.075e-32
Identity = 73/156 (46.79%), Postives = 105/156 (67.31%), Query Frame = 1

Query:   82 MLREVFEMGKELADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATS 549
            ML  V   GK++A+K+TN  +N +E+E K++ ATNDD WGP+G  M+EIA+ T     L +VM  LW R+F E+  N RRTYK L+LL+YL+ NGSE I  SC+ H+ D++ L+S  YID +G    + IR K+ ++  LL +  +LS+ERK+A S
Sbjct:    1 MLSNVINAGKDIANKLTNKFLNLSEIEVKIKTATNDDNWGPNGSLMREIADETFSTTNLQEVMTFLWYRIFTEKPPNNRRTYKGLVLLTYLIVNGSELIAASCRAHLGDIKKLQS--YIDGHGV-ADVAIRRKASDICDLLSDSQRLSDERKRAKS 153

[Close]

BLAST of ENTH domain-containing protein vs. Planmine SMEST
Match: SMESG000042233.1 (SMESG000042233.1)

HSP 1 Score: 119.398 bits (298), Expect = 3.934e-28
Identity = 68/165 (41.21%), Postives = 102/165 (61.82%), Query Frame = 1

Query:  112 ELADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISG-SVNGHRR 603
            E+  KV N V  Y+E E  VR AT++DPWGP    M EIA+ T  Y     +M ++W+R+  ++  NWR  YKSL+LL YL++ G+ERI   C ++I+ +  L+ +QY +E+ KD G+ IR KSK L+ LL+++  L+NER K    + K++   S    + HRR
Sbjct:    2 EIRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRL-NDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFEEH-KDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRR 164

[Close]

BLAST of ENTH domain-containing protein vs. Planmine SMEST
Match: SMESG000042233.1 (SMESG000042233.1)

HSP 1 Score: 119.013 bits (297), Expect = 4.204e-28
Identity = 68/165 (41.21%), Postives = 102/165 (61.82%), Query Frame = 1

Query:  112 ELADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKXXXXXXXXXRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKYKAGISG-SVNGHRR 603
            E+  KV N V  Y+E E  VR AT++DPWGP    M EIA+ T  Y     +M ++W+R+  ++  NWR  YKSL+LL YL++ G+ERI   C ++I+ +  L+ +QY +E+ KD G+ IR KSK L+ LL+++  L+NER K    + K++   S    + HRR
Sbjct:    2 EIRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRL-NDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFEEH-KDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRR 164

The following BLAST results are available for this feature:

BLAST of ENTH domain-containing protein vs. Ensembl Human
BLAST of ENTH domain-containing protein vs. Ensembl Celegans
BLAST of ENTH domain-containing protein vs. Ensembl Fly
BLAST of ENTH domain-containing protein vs. Ensembl Zebrafish
BLAST of ENTH domain-containing protein vs. Ensembl Xenopus
BLAST of ENTH domain-containing protein vs. Ensembl Mouse
BLAST of ENTH domain-containing protein vs. UniProt/SwissProt
BLAST of ENTH domain-containing protein vs. TrEMBL
BLAST of ENTH domain-containing protein vs. Ensembl Cavefish
BLAST of ENTH domain-containing protein vs. Ensembl Sea Lamprey
BLAST of ENTH domain-containing protein vs. Ensembl Yeast
BLAST of ENTH domain-containing protein vs. Ensembl Nematostella
BLAST of ENTH domain-containing protein vs. Ensembl Medaka
BLAST of ENTH domain-containing protein vs. Planmine SMEST

BLAST of ENTH domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
CLINT1	2.273e-51	60.37	clathrin interactor 1 [Source:HGNC Symbol;Acc:HGNC...	[more]
CLINT1	2.688e-51	60.37	clathrin interactor 1 [Source:HGNC Symbol;Acc:HGNC...	[more]
CLINT1	2.837e-46	60.13	clathrin interactor 1 [Source:HGNC Symbol;Acc:HGNC...	[more]
CLINT1	2.837e-46	60.13	clathrin interactor 1 [Source:HGNC Symbol;Acc:HGNC...	[more]
EPN3	9.060e-39	42.65	epsin 3 [Source:HGNC Symbol;Acc:HGNC:18235]	[more]

BLAST of ENTH domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 3


Match Name	E-value	Identity	Description
rsd-3	9.623e-37	46.88	pep chromosome:WBcel235:X:11798505:11803656:1 gene...	[more]
epn-1	9.142e-30	37.42	EPsiN (Endocytic protein) homolog [Source:UniProt...	[more]
epn-1	9.714e-30	37.42	EPsiN (Endocytic protein) homolog [Source:UniProt...	[more]

BLAST of ENTH domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
lqfR	2.061e-54	63.41	gene:FBgn0261279 transcript:FBtr0299515	[more]
lqfR	3.932e-52	63.41	gene:FBgn0261279 transcript:FBtr0299516	[more]
lqf	3.080e-30	41.03	gene:FBgn0028582 transcript:FBtr0076796	[more]
lqf	3.080e-30	41.03	gene:FBgn0028582 transcript:FBtr0076794	[more]
lqf	3.169e-30	41.03	gene:FBgn0028582 transcript:FBtr0076798	[more]

BLAST of ENTH domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
clint1a	8.077e-56	60.98	clathrin interactor 1a [Source:ZFIN;Acc:ZDB-GENE-0...	[more]
clint1a	1.322e-52	61.15	clathrin interactor 1a [Source:ZFIN;Acc:ZDB-GENE-0...	[more]
clint1b	7.861e-45	57.50	clathrin interactor 1b [Source:ZFIN;Acc:ZDB-GENE-1...	[more]
epn2	2.287e-35	43.75	epsin 2 [Source:ZFIN;Acc:ZDB-GENE-071212-1]	[more]
epn2	2.480e-35	43.75	epsin 2 [Source:ZFIN;Acc:ZDB-GENE-071212-1]	[more]

BLAST of ENTH domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
cyct	2.229e-51	59.04	cytochrome c, testis [Source:Xenbase;Acc:XB-GENE-5...	[more]
cyct	2.364e-48	59.12	cytochrome c, testis [Source:Xenbase;Acc:XB-GENE-5...	[more]
cyct	3.059e-48	59.12	cytochrome c, testis [Source:Xenbase;Acc:XB-GENE-5...	[more]
uvssa	3.570e-35	43.33	UV stimulated scaffold protein A [Source:Xenbase;A...	[more]
uvssa	4.301e-35	43.33	UV stimulated scaffold protein A [Source:Xenbase;A...	[more]

BLAST of ENTH domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Clint1	2.542e-51	60.37	clathrin interactor 1 [Source:MGI Symbol;Acc:MGI:2...	[more]
Clint1	3.387e-51	60.37	clathrin interactor 1 [Source:MGI Symbol;Acc:MGI:2...	[more]
Epn3	2.268e-35	44.51	epsin 3 [Source:MGI Symbol;Acc:MGI:1919139]	[more]
Epn2	8.883e-35	44.44	epsin 2 [Source:MGI Symbol;Acc:MGI:1333766]	[more]
Epn2	9.779e-35	44.44	epsin 2 [Source:MGI Symbol;Acc:MGI:1333766]	[more]

BLAST of ENTH domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q14677\|EPN4_HUMAN	1.091e-50	60.37	Clathrin interactor 1 OS=Homo sapiens OX=9606 GN=C...	[more]
sp\|A7Z035\|EPN4_BOVIN	1.559e-50	60.37	Clathrin interactor 1 OS=Bos taurus OX=9913 GN=CLI...	[more]
sp\|Q99KN9\|EPN4_MOUSE	2.450e-47	60.51	Clathrin interactor 1 OS=Mus musculus OX=10090 GN=...	[more]
sp\|Q9H201\|EPN3_HUMAN	3.086e-36	47.02	Epsin-3 OS=Homo sapiens OX=9606 GN=EPN3 PE=2 SV=1	[more]
sp\|Q91W69\|EPN3_MOUSE	1.586e-34	44.51	Epsin-3 OS=Mus musculus OX=10090 GN=Epn3 PE=1 SV=1	[more]

BLAST of ENTH domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A1I8IYT0	6.154e-58	63.98	ENTH domain-containing protein OS=Macrostomum lign...	[more]
A0A3M7SRR7	2.248e-57	63.58	Clathrin interactor 1-like (Fragment) OS=Brachionu...	[more]
A0A267E6W1	2.420e-57	63.98	ENTH domain-containing protein OS=Macrostomum lign...	[more]
A7RIC8	5.070e-55	58.48	Predicted protein (Fragment) OS=Nematostella vecte...	[more]
K1Q680	2.212e-54	64.56	Clathrin interactor 1 OS=Crassostrea gigas OX=2915...	[more]

BLAST of ENTH domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
clint1a	4.479e-52	57.49	clathrin interactor 1a [Source:ZFIN;Acc:ZDB-GENE-0...	[more]
epn3a	2.866e-37	48.73	epsin 3 [Source:NCBI gene;Acc:103029089]	[more]
epn3a	3.428e-37	48.73	epsin 3 [Source:NCBI gene;Acc:103029089]	[more]
epn3a	3.428e-37	48.73	epsin 3 [Source:NCBI gene;Acc:103029089]	[more]
epn2	1.216e-35	42.50	epsin 2 [Source:ZFIN;Acc:ZDB-GENE-071212-1]	[more]

BLAST of ENTH domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2


Match Name	E-value	Identity	Description
clint1a	4.248e-52	55.88	clathrin interactor 1a [Source:ZFIN;Acc:ZDB-GENE-0...	[more]
epn2	1.326e-36	43.59	epsin 2 [Source:ZFIN;Acc:ZDB-GENE-071212-1]	[more]

BLAST of ENTH domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 3


Match Name	E-value	Identity	Description
ENT3	8.781e-34	42.42	Protein containing an N-terminal epsin-like domain...	[more]
ENT1	1.698e-15	34.25	Epsin-like protein involved in endocytosis and act...	[more]
ENT2	6.019e-15	34.25	Epsin-like protein required for endocytosis and ac...	[more]

BLAST of ENTH domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2


Match Name	E-value	Identity	Description
EDO48788	6.866e-59	58.48	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO36992	1.159e-36	42.86	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of ENTH domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
clint1a	1.175e-52	59.04	clathrin interactor 1 [Source:NCBI gene;Acc:101169...	[more]
CLINT1	1.380e-48	61.84	clathrin interactor 1 [Source:NCBI gene;Acc:101160...	[more]
CLINT1	1.411e-48	61.84	clathrin interactor 1 [Source:NCBI gene;Acc:101160...	[more]
epn2	2.021e-35	43.51	epsin 2 [Source:NCBI gene;Acc:101161060]	[more]
epn1	4.245e-35	44.97	epsin-1 [Source:NCBI gene;Acc:101167232]	[more]

BLAST of ENTH domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000019746.1	0.000e+0	99.37	SMESG000019746.1	[more]
SMESG000032527.1	1.071e-32	46.79	SMESG000032527.1	[more]
SMESG000032527.1	1.075e-32	46.79	SMESG000032527.1	[more]
SMESG000042233.1	3.934e-28	41.21	SMESG000042233.1	[more]
SMESG000042233.1	4.204e-28	41.21	SMESG000042233.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30030824 ID=SMED30030824|Name=ENTH domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1818bp
GTAAATAATTACTAAGTTTCCTTTTTGCACTATTTAATATTTTAGATTAC
ATTTTTAGTTTTTAGATAATTAGATTTATCAATGTTGCGAGAAGTCTTTG
AAATGGGAAAAGAATTAGCTGATAAAGTGACAAACGCGGTTATGAATTAC
ACGGAAGTTGAAGCAAAGGTCCGAGCAGCGACAAACGATGATCCATGGGG
TCCTCATGGCCAAGACATGCAGGAGATTGCGGAATTTACTAAGCATTATG
ACACATTGACACAAGTAATGGGAATGTTGTGGAGGAGAATGTTCCAAGAA
CAGAAAAGTAACTGGAGAAGGACATACAAGTCGCTTCTGCTGCTGTCATA
TTTGTTACGGAACGGATCCGAGAGGATTGTCATCAGCTGCAAAGAGCACA
TCTATGATTTGCGGTTGTTGGAATCATATCAATATATCGATGAAAACGGC
AAGGATCAAGGAATTAATATCAGGCACAAAAGCAAGGAGCTGATTGGATT
GCTGGAGAATGAATCCCAGCTGTCCAATGAGCGTAAGAAAGCCACATCAA
ATAGGAGCAAGTACAAGGCAGGGATAAGCGGCTCGGTAAATGGGCACCGC
CGGTATTGGAATAGTGATGACATGAAAGCAACTGAGAGATCGACACGCGA
GAGATCTTGTACCCCGCCTTCACCGTCAGTTAACGGATCCTCCAGACCCC
CAGCAAAACCTCCCGTTGACCTGAAACCGGTCGCGGTGGTTAGCAAACCG
GCGGAACCGATTGCTGACCTGCTTGATTTGAATGTGCCGATGGCAGATAG
CACCAATTTGCCGCCACTCAATCACTGTGCCAATAACGCCGCTGACACCT
CATTTGACCCGTTTAACCTTGGCAACGAGCACCGGGAGTTCACGGTTCCC
CCAGTCCCCTCCAATCCCACATCGCCCACGTCGCCATGCAATCCTCGCTA
TTCTGATGACTTTGACAGCTTTGTATCGGCTGCGCCTCCGGTACCGCTAC
CTACCTCAAATCTCGCGGACCTCGACTTGGTATTTGGGAACTTTATCGAC
AGCAGTAGCAATAACGATATCAGTAACAATCCGGTTGCCTTAGGCACCAC
CGGAAGGCCGACACTCATCACCCAGACTCCCATGACACCAAAAGCCATTT
CCGTTGCCACTGACAACGGGAAATCGGACAAAATGATCATCGGTTCCACT
TGGTCTGACGTTGGTGGCATCAATATCAGTTTGGACTTACTGAGCAACCG
AGGCCAGAAAGCCACTCACTCGGTCACCTCGTCTAAATCTCTTAATCAAC
TCCAGCAGCAAAATGTTTTCAATTCCAATAACGATTCCAATAAAATATAT
TCAAATTCCAGAAAGCAACCATTTGACTCACCAAAGAATCATCCGCATCA
AAGCAGAAATGTAGCAGCCAATGAAAAGCTTAGCAATGCAAATGTGTCAT
TCGGTCAGGTCAATCACTCCTCAGCTAATCAGTTTGTCGCATTCAATGAT
TTGCTGCAATGATTGGTTGGATTAGTTTATTGATCGGTGGTGATTGGTGG
AGATATCACCGATATTCAATAATATGATAATAATCAATAATTATAATAAT
AATCAATAATAGTAATAATAGTGATGATCATGTGCTCATTAGAATATTTT
ATCAATACCTTTGATTACCTTACCAAGTGGCTTTATTTGTTGTGACAATT
TTAATACCTGTTTATTGGTTGATTGGTTACCTTGTCAACCGTTCTGAGTT
CATTATTTATTTTGCTGCTGAATGATTATGAGTGAGTGAGTGAATGTTGC
TATGGTGTAGAAATCGGA

protein sequence of SMED30030824-orf-1

>SMED30030824-orf-1 ID=SMED30030824-orf-1|Name=SMED30030824-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=477bp
MLREVFEMGKELADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIA
EFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKSLLLLSYLLRNGSERIV
ISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNE
RKKATSNRSKYKAGISGSVNGHRRYWNSDDMKATERSTRERSCTPPSPSV
NGSSRPPAKPPVDLKPVAVVSKPAEPIADLLDLNVPMADSTNLPPLNHCA
NNAADTSFDPFNLGNEHREFTVPPVPSNPTSPTSPCNPRYSDDFDSFVSA
APPVPLPTSNLADLDLVFGNFIDSSSNNDISNNPVALGTTGRPTLITQTP
MTPKAISVATDNGKSDKMIIGSTWSDVGGINISLDLLSNRGQKATHSVTS
SKSLNQLQQQNVFNSNNDSNKIYSNSRKQPFDSPKNHPHQSRNVAANEKL
SNANVSFGQVNHSSANQFVAFNDLLQ*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **cellular component**
Term	Definition
GO:0016020	membrane
GO:0005737	cytoplasm
GO:0005770	late endosome
GO:0005794	Golgi apparatus
GO:0005856	cytoskeleton
GO:0005884	actin filament
GO:0009579	thylakoid
GO:0030136	clathrin-coated vesicle
GO:0031410	cytoplasmic vesicle

Vocabulary: **biological process**
Term	Definition
GO:0016192	vesicle-mediated transport
GO:0055114	oxidation-reduction process
GO:0006623	protein targeting to vacuole
GO:0006810	transport
GO:0015031	protein transport

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000020	protonephridia
PLANA:0000026	gut
PLANA:0000034	epidermis
PLANA:0000074	oocyte
PLANA:0000101	muscle cell
PLANA:0000208	testis
PLANA:0000231	vitelline gland
PLANA:0002032	epidermal cell
PLANA:0003116	parenchymal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR030544	CLINT1
IPR013809	ENTH
IPR008942	ENTH_VHS
IPR019774	Aromatic-AA_hydroxylase_C

Vocabulary: **molecular function**
Term	Definition
GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
GO:0002020	protease binding
GO:0005515	protein binding
GO:0030276	clathrin binding

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR013809	ENTH domain	SMART	SM00273	enth_2	coord: 24..151 e-value: 5.4E-46 score: 168.8
IPR013809	ENTH domain	PFAM	PF01417	ENTH	coord: 23..147 e-value: 2.3E-43 score: 147.2
IPR013809	ENTH domain	PROSITE	PS50942	ENTH	coord: 18..151 score: 40.371
IPR008942	ENTH/VHS	GENE3D	G3DSA:1.25.40.90		coord: 18..165 e-value: 9.6E-58 score: 196.2
IPR008942	ENTH/VHS	SUPERFAMILY	SSF48464	ENTH/VHS domain	coord: 8..151
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 173..211
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 175..189
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 145..164
None	No IPR available	PANTHER	PTHR12276	EPSIN/ENT-RELATED	coord: 10..189
None	No IPR available	CDD	cd16989	ENTH_EpsinR	coord: 26..154 e-value: 4.32893E-72 score: 222.166
IPR030544	Clathrin interactor 1	PANTHER	PTHR12276:SF83	CLATHRIN INTERACTOR 1	coord: 10..189