A-kinase anchor protein 17A

Overview


Name	A-kinase anchor protein 17A
Smed ID	SMED30030822
Length (bp)	1407

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of A-kinase anchor protein 17A (SMED30030822) t-SNE clustered cells

Violin plots show distribution of expression levels for A-kinase anchor protein 17A (SMED30030822) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of A-kinase anchor protein 17A (SMED30030822) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for A-kinase anchor protein 17A (SMED30030822) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30030822

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 16

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
Smed sexual biotype	SMED30030822	h1SMcG0007735	Contig41167	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30030822	h1SMcG0007735	Contig41167	newmark_ests	PMID:29674431 Fincher et al., 2018
protonephridia	SMED30030822	h1SMcG0007735	dd_Smed_v4_3404_1_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
nervous system	SMED30030822	h1SMcG0007735	dd_Smed_v4_3404_1_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30030822	h1SMcG0007735	dd_Smed_v4_3404_1_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30030822	h1SMcG0007735	dd_Smed_v4_3404_1_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30030822	h1SMcG0007735	dd_Smed_v4_3404_1_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30030822	h1SMcG0007735	Contig33663	newmark_ests	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30030822	h1SMcG0007735	Contig33663	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
protonephridia	SMED30030822	h1SMcG0007736	dd_Smed_v4_3404_1_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
nervous system	SMED30030822	h1SMcG0007736	dd_Smed_v4_3404_1_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30030822	h1SMcG0007736	dd_Smed_v4_3404_1_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30030822	h1SMcG0007736	dd_Smed_v4_3404_1_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30030822	h1SMcG0007736	dd_Smed_v4_3404_1_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cholinergic neuron	SMED30030822	h1SMcG0007736	dd_Smed_v6_3404_1	dd_Smed_v6	PMID:29674432 Plass et al., 2018
cholinergic neuron	SMED30030822	h1SMcG0007735	dd_Smed_v6_3404_1	dd_Smed_v6	PMID:29674432 Plass et al., 2018

Note: Hover over icons to view figure legend

Homology

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BLAST of A-kinase anchor protein 17A vs. Ensembl Human
Match: AKAP17A (A-kinase anchoring protein 17A [Source:HGNC Symbol;Acc:HGNC:18783])

HSP 1 Score: 125.561 bits (314), Expect = 2.621e-31
Identity = 75/247 (30.36%), Postives = 129/247 (52.23%), Query Frame = 1

Query:   70 LSNWELLEKIHLLVTPYSFLQLKVTLNTVDGIQLEGETETKSDCKKIVNLLQDMKFKISGIPEYFHISASIYASNITNKNEFSKKYHEARNSDPNI--DRLDTLHIKGLPTLWFSDKNAEGDFKNKPVQQIVESVFSKFGSIRNMYIPINNPLFSNTDGGFNSIVSINSSKIDAVTTILTFEAFIQYKSYKDLLNAISHLKNRKLVFK--DGKFGDSSNSFNLFNAEIVIDFDQSDCLSDYSIRKRN 798
            +SNWE++E++  +V  + F  L+++ +T+D I+ EGE E KS  K  +  L     K+SG  +   + A+ +  +   ++++   + +A++ +  +  +R DT+H++GLP  WF+ K +  +   KP + ++  VF KFG IRN+ IP+ +P      G      S            L FEA++QY+ Y   + A+S L+  KL++K  DGK              I + FD +  LSD SI+KR 
Sbjct:   46 ISNWEVMERLKGMVQNHQFSTLRISKSTMDFIRFEGEVENKSLVKSFLACLDGKTIKLSGFSDILKVRAAEFKIDFPTRHDWDSFFRDAKDMNETLPGERPDTIHLEGLPCKWFALKESGSE---KPSEDVLVKVFEKFGEIRNVDIPMLDPYREEMTGRNFHTFSFGGH--------LNFEAYVQYREYMGFIQAMSALRGMKLMYKGEDGK---------AVACNIKVSFDSTKHLSDASIKKRQ 272

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BLAST of A-kinase anchor protein 17A vs. Ensembl Human
Match: AKAP17A (A-kinase anchoring protein 17A [Source:HGNC Symbol;Acc:HGNC:18783])

HSP 1 Score: 124.405 bits (311), Expect = 1.739e-30
Identity = 75/247 (30.36%), Postives = 129/247 (52.23%), Query Frame = 1

Query:   70 LSNWELLEKIHLLVTPYSFLQLKVTLNTVDGIQLEGETETKSDCKKIVNLLQDMKFKISGIPEYFHISASIYASNITNKNEFSKKYHEARNSDPNI--DRLDTLHIKGLPTLWFSDKNAEGDFKNKPVQQIVESVFSKFGSIRNMYIPINNPLFSNTDGGFNSIVSINSSKIDAVTTILTFEAFIQYKSYKDLLNAISHLKNRKLVFK--DGKFGDSSNSFNLFNAEIVIDFDQSDCLSDYSIRKRN 798
            +SNWE++E++  +V  + F  L+++ +T+D I+ EGE E KS  K  +  L     K+SG  +   + A+ +  +   ++++   + +A++ +  +  +R DT+H++GLP  WF+ K +  +   KP + ++  VF KFG IRN+ IP+ +P      G      S            L FEA++QY+ Y   + A+S L+  KL++K  DGK              I + FD +  LSD SI+KR 
Sbjct:   46 ISNWEVMERLKGMVQNHQFSTLRISKSTMDFIRFEGEVENKSLVKSFLACLDGKTIKLSGFSDILKVRAAEFKIDFPTRHDWDSFFRDAKDMNETLPGERPDTIHLEGLPCKWFALKESGSE---KPSEDVLVKVFEKFGEIRNVDIPMLDPYREEMTGRNFHTFSFGGH--------LNFEAYVQYREYMGFIQAMSALRGMKLMYKGEDGK---------AVACNIKVSFDSTKHLSDASIKKRQ 272

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BLAST of A-kinase anchor protein 17A vs. Ensembl Human
Match: AKAP17A (A-kinase anchoring protein 17A [Source:HGNC Symbol;Acc:HGNC:18783])

HSP 1 Score: 122.865 bits (307), Expect = 2.783e-29
Identity = 75/247 (30.36%), Postives = 129/247 (52.23%), Query Frame = 1

Query:   70 LSNWELLEKIHLLVTPYSFLQLKVTLNTVDGIQLEGETETKSDCKKIVNLLQDMKFKISGIPEYFHISASIYASNITNKNEFSKKYHEARNSDPNI--DRLDTLHIKGLPTLWFSDKNAEGDFKNKPVQQIVESVFSKFGSIRNMYIPINNPLFSNTDGGFNSIVSINSSKIDAVTTILTFEAFIQYKSYKDLLNAISHLKNRKLVFK--DGKFGDSSNSFNLFNAEIVIDFDQSDCLSDYSIRKRN 798
            +SNWE++E++  +V  + F  L+++ +T+D I+ EGE E KS  K  +  L     K+SG  +   + A+ +  +   ++++   + +A++ +  +  +R DT+H++GLP  WF+ K +  +   KP + ++  VF KFG IRN+ IP+ +P      G      S            L FEA++QY+ Y   + A+S L+  KL++K  DGK              I + FD +  LSD SI+KR 
Sbjct:   46 ISNWEVMERLKGMVQNHQFSTLRISKSTMDFIRFEGEVENKSLVKSFLACLDGKTIKLSGFSDILKVRAAEFKIDFPTRHDWDSFFRDAKDMNETLPGERPDTIHLEGLPCKWFALKESGSE---KPSEDVLVKVFEKFGEIRNVDIPMLDPYREEMTGRNFHTFSFGGH--------LNFEAYVQYREYMGFIQAMSALRGMKLMYKGEDGK---------AVACNIKVSFDSTKHLSDASIKKRQ 272

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BLAST of A-kinase anchor protein 17A vs. Ensembl Celegans
Match: cux-7 (Clk-2 Upstream, human gene XE7 related [Source:UniProtKB/TrEMBL;Acc:Q95YE8])

HSP 1 Score: 98.5969 bits (244), Expect = 6.459e-22
Identity = 66/248 (26.61%), Postives = 117/248 (47.18%), Query Frame = 1

Query:   61 NEVLSNWELLEKIHLLVTPYSFLQLKVTLNTVDGIQLEGETETKSDCKKIVNLLQDMKFKISGIPEYFHISASIYASNITNKNEFSKKY--HEARNSDPNIDRLDTLHIKGLPTLWFSDKNAEGDFKNKPVQQIVESVFSKFGSIRNMYIPINNPLFSNTDGGFNSIVSINSSKIDAVTTILTFEAFIQYKSYKDLLNAISHLKNRKLVFK-DGKFGDSSNSFNLFNAEIVIDFDQSDCLSDYSIRKR 795
             + +SNW+L+E++   + P      KV  + +D +  E E  +    +K + +L     K+SG  E   +       +  +++++   +  H+     P  +R DT+++  +P  WF D      + + P ++ +      FGS+R + IPI +PL S      NS +S    K   +   + FEA++Q+  YK    A+  L+NRK   + DG+F         F A + +DFD+S  LS+  I KR
Sbjct:   46 GQSISNWDLMERLKRAIDPIQMDSCKVRESNIDSVIFEAELLSLGIMQKTMKILDGFSMKVSGFAEPLKVKTKEAKLDFPSRHDWDDWFMKHKMDEMKPG-ERPDTVYLARIPVKWFCD-----GYNDLPSERRLRVAMEAFGSVRVVDIPICDPLRSR----MNSKISGIQQKGFGLGQDVFFEAYVQFMEYKGFATAMDSLRNRKWAKRIDGRF---------FQANVKVDFDRSRHLSEVQIAKR 274

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Query:   61 NEVLSNWELLEKIHLLVTPYSFLQLKVTLNTVDGIQLEGETETKSDCKKIVNLLQDMKFKISGIPEYFHISASIYASNITNKNEFSKKY--HEARNSDPNIDRLDTLHIKGLPTLWFSDKNAEGDFKNKPVQQIVESVFSKFGSIRNMYIPINNPLFSNTDGGFNSIVSINSSKIDAVTTILTFEAFIQYKSYKDLLNAISHLKNRKLVFK-DGKFGDSSNSFNLFNAEIVIDFDQSDCLSDYSIRKR 795
             + +SNW+L+E++   + P      KV  + +D +  E E  +    +K + +L     K+SG  E   +       +  +++++   +  H+     P  +R DT+++  +P  WF D      + + P ++ +      FGS+R + IPI +PL S      NS +S    K   +   + FEA++Q+  YK    A+  L+NRK   + DG+F         F A + +DFD+S  LS+  I KR
Sbjct:   46 GQSISNWDLMERLKRAIDPIQMDSCKVRESNIDSVIFEAELLSLGIMQKTMKILDGFSMKVSGFAEPLKVKTKEAKLDFPSRHDWDDWFMKHKMDEMKPG-ERPDTVYLARIPVKWFCD-----GYNDLPSERRLRVAMEAFGSVRVVDIPICDPLRSR----MNSKISGIQQKGFGLGQDVFFEAYVQFMEYKGFATAMDSLRNRKWAKRIDGRF---------FQANVKVDFDRSRHLSEVQIAKR 274

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Query:   61 NEVLSNWELLEKIHLLVTPYSFLQLKVTLNTVDGIQLEGETETKSDCKKIVNLLQDMKFKISGIPEYFHISASIYASNITNKNEFSKKY--HEARNSDPNIDRLDTLHIKGLPTLWFSDKNAEGDFKNKPVQQIVESVFSKFGSIRNMYIPINNPLFSNTDGGFNSIVSINSSKIDAVTTILTFEAFIQYKSYKDLLNAISHLKNRKLVFK-DGKFGDSSNSFNLFNAEIVIDFDQSDCLSDYSIRKR 795
             + +SNW+L+E++   + P      KV  + +D +  E E  +    +K + +L     K+SG  E   +       +  +++++   +  H+     P  +R DT+++  +P  WF D      + + P ++ +      FGS+R + IPI +PL S      NS +S    K   +   + FEA++Q+  YK    A+  L+NRK   + DG+F         F A + +DFD+S  LS+  I KR
Sbjct:   46 GQSISNWDLMERLKRAIDPIQMDSCKVRESNIDSVIFEAELLSLGIMQKTMKILDGFSMKVSGFAEPLKVKTKEAKLDFPSRHDWDDWFMKHKMDEMKPG-ERPDTVYLARIPVKWFCD-----GYNDLPSERRLRVAMEAFGSVRVVDIPICDPLRSR----MNSKISGIQQKGFGLGQDVFFEAYVQFMEYKGFATAMDSLRNRKWAKRIDGRF---------FQANVKVDFDRSRHLSEVQIAKR 274

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BLAST of A-kinase anchor protein 17A vs. Ensembl Fly
Match: Xe7 (gene:FBgn0010772 transcript:FBtr0334952)

HSP 1 Score: 123.635 bits (309), Expect = 2.784e-31
Identity = 79/285 (27.72%), Postives = 145/285 (50.88%), Query Frame = 1

Query:   37 IPVFKIFKNEVLSNWELLEKIHLLVTPYSFLQLKVTLNTVDGIQLEGETETKSDCKKIVNLLQDMKFKISGIPEYFHISASIYASNITNKNEFSKKYHEARNSDP--NIDRLDTLHIKGLPTLWFSDKNAEGDFKNKPVQQIVESVFSKFGSIRNMYIPINNPLFSNTDGGFNSIVSINSSKIDAVTTILTFEAFIQYKSYKDLLNAISHLKNRKLVFKDGKFGDSSNSFNLFNAEIVIDFDQSDCLSDYSIRKRNKSIKEYFMRIK-----ENSLKEQKKKECD 870
            +P  K  K+  +SN E+++K+   + P  FL LKV+ +TV+ I+LE E + +   +  +  L  +  +ISG  E F +  +    +   ++++   + +ARN D     +R DT+HI  LP  WF  +++E +   KP + I + +F KFG +R + IPI +P   +     N + +       +    + FE ++Q++ Y   + A+   +  KLV    KF D + + N     I + FD+   LSD +I++R +  K++  + K        LK+Q+++E D
Sbjct:   36 LPTIKSGKS--VSNLEIMDKLGAELKPDKFLLLKVSKSTVNTIRLEAELDERKRLRAAIQRLDGISLRISGFSESFRVRCAESKDDFPTRHDWDSYFRDARNMDEMKAGERPDTIHISHLPMRWFCPRHSEHEENVKPSENIFKRIFEKFGRVRMVDIPICDPYRKSMQADINGMRTF------SFEQDVLFEGYVQFEEYSSFVRAMDEFRGNKLV---RKFVDKTQAIN-----ICVSFDKQKHLSDSNIQRRERIRKKFIAKAKAEDEEREKLKKQQEEELD 304

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BLAST of A-kinase anchor protein 17A vs. Ensembl Fly
Match: Xe7 (gene:FBgn0010772 transcript:FBtr0334951)

HSP 1 Score: 125.176 bits (313), Expect = 2.654e-30
Identity = 95/367 (25.89%), Postives = 185/367 (50.41%), Query Frame = 1

Query:    7 KMVIFIN*AKIPVFKIFKNEVLSNWELLEKIHLLVTPYSFLQLKVTLNTVDGIQLEGETETKSDCKKIVNLLQDMKFKISGIPEYFHISASIYASNITNKNEFSKKYHEARNSDP--NIDRLDTLHIKGLPTLWFSDKNAEGDFKNKPVQQIVESVFSKFGSIRNMYIPINNPLFSNTDGGFNSIVSINSSKIDAVTTILTFEAFIQYKSYKDLLNAISHLKNRKLVFKDGKFGDSSNSFNLFNAEIVIDFDQSDCLSDYSIRKRNKSIKEYFMRIK-ENSLKEQKKKECDGILNEKLKSQ---------VVXXXXXXXXXXXXEDFDENAXXXXXXXXXXXXXXXYIGQQKIESVRVLSILYDKLK 1071
            KM I ++   +P  K  K+  +SN E+++K+   + P  FL LKV+ +TV+ I+LE E + +   +  +  L  +  +ISG  E F +  +    +   ++++   + +ARN D     +R DT+HI  LP  WF  +++E +   KP + I + +F KFG +R + IPI +P   +     N + +       +    + FE ++Q++ Y   + A+   +  KLV    KF D + + N     I + FD+   LSD +I++R +  K++  + K E+  +E+ KK+ +  L+ + + Q           + +  ++ ++  +   E  +     K  ++E K  I Q+K+ES+R L  L+++++
Sbjct:   29 KMQISVS---LPTIKSGKS--VSNLEIMDKLGAELKPDKFLLLKVSKSTVNTIRLEAELDERKRLRAAIQRLDGISLRISGFSESFRVRCAESKDDFPTRHDWDSYFRDARNMDEMKAGERPDTIHISHLPMRWFCPRHSEHEENVKPSENIFKRIFEKFGRVRMVDIPICDPYRKSMQADINGMRTF------SFEQDVLFEGYVQFEEYSSFVRAMDEFRGNKLV---RKFVDKTQAIN-----ICVSFDKQKHLSDSNIQRRERIRKKFIAKAKAEDEEREKLKKQQEEELDRERQKQEELKKAEAEKQREREERRKEKHMKKIQERGQVEISQKIRIEERKLMIAQRKLESIRTLEKLFERIQ 376

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BLAST of A-kinase anchor protein 17A vs. Ensembl Fly
Match: Xe7 (gene:FBgn0010772 transcript:FBtr0078728)

HSP 1 Score: 125.176 bits (313), Expect = 2.934e-30
Identity = 95/367 (25.89%), Postives = 185/367 (50.41%), Query Frame = 1

Query:    7 KMVIFIN*AKIPVFKIFKNEVLSNWELLEKIHLLVTPYSFLQLKVTLNTVDGIQLEGETETKSDCKKIVNLLQDMKFKISGIPEYFHISASIYASNITNKNEFSKKYHEARNSDP--NIDRLDTLHIKGLPTLWFSDKNAEGDFKNKPVQQIVESVFSKFGSIRNMYIPINNPLFSNTDGGFNSIVSINSSKIDAVTTILTFEAFIQYKSYKDLLNAISHLKNRKLVFKDGKFGDSSNSFNLFNAEIVIDFDQSDCLSDYSIRKRNKSIKEYFMRIK-ENSLKEQKKKECDGILNEKLKSQ---------VVXXXXXXXXXXXXEDFDENAXXXXXXXXXXXXXXXYIGQQKIESVRVLSILYDKLK 1071
            KM I ++   +P  K  K+  +SN E+++K+   + P  FL LKV+ +TV+ I+LE E + +   +  +  L  +  +ISG  E F +  +    +   ++++   + +ARN D     +R DT+HI  LP  WF  +++E +   KP + I + +F KFG +R + IPI +P   +     N + +       +    + FE ++Q++ Y   + A+   +  KLV    KF D + + N     I + FD+   LSD +I++R +  K++  + K E+  +E+ KK+ +  L+ + + Q           + +  ++ ++  +   E  +     K  ++E K  I Q+K+ES+R L  L+++++
Sbjct:   29 KMQISVS---LPTIKSGKS--VSNLEIMDKLGAELKPDKFLLLKVSKSTVNTIRLEAELDERKRLRAAIQRLDGISLRISGFSESFRVRCAESKDDFPTRHDWDSYFRDARNMDEMKAGERPDTIHISHLPMRWFCPRHSEHEENVKPSENIFKRIFEKFGRVRMVDIPICDPYRKSMQADINGMRTF------SFEQDVLFEGYVQFEEYSSFVRAMDEFRGNKLV---RKFVDKTQAIN-----ICVSFDKQKHLSDSNIQRRERIRKKFIAKAKAEDEEREKLKKQQEEELDRERQKQEELKKAEAEKQREREERRKEKHMKKIQERGQVEISQKIRIEERKLMIAQRKLESIRTLEKLFERIQ 376

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BLAST of A-kinase anchor protein 17A vs. Ensembl Zebrafish
Match: akap17a (A kinase (PRKA) anchor protein 17A [Source:ZFIN;Acc:ZDB-GENE-040426-1460])

HSP 1 Score: 134.035 bits (336), Expect = 1.283e-33
Identity = 75/257 (29.18%), Postives = 139/257 (54.09%), Query Frame = 1

Query:   37 IPVFKIFKNEVLSNWELLEKIHLLVTPYSFLQLKVTLNTVDGIQLEGETETKSDCKKIVNLLQDMKFKISGIPEYFHISASIYASNITNKNEFSKKYHEARNSDPNI--DRLDTLHIKGLPTLWFSDKNAEGDFKNKPVQQIVESVFSKFGSIRNMYIPINNPLFSNTDGGFNSIVSINSSKIDAVTTILTFEAFIQYKSYKDLLNAISHLKNRKLVFKDGKFGDSSNSFNLFNAEIVIDFDQSDCLSDYSIRKRNK 801
            +P  K+   + +SNWE++E++  +V P  F  L+++ +T+D I+ EGE ET+S  K+I++ L+    K+SG  +   +  +    +   ++++   + +A++ +  +  +R DT+ ++GLP  WF+ K+   D   +P + ++++VF KFG IRN+ IP+ +P   +  G   S  S            L FEAF+QY  +   L A+  L+  KL+F+    GD   +       I + FD +  LS+ S++KR +
Sbjct:   34 LPHLKL-PGKSISNWEVMERLKAMVQPEQFSALRISKSTMDFIRFEGEVETRSAVKRILSRLEGKSIKLSGFTDTLKVRTAENKVDFPTRHDWDSFFRDAKDMNETVPGERPDTVRLEGLPCKWFAQKDGSPD---RPSEAVLKTVFEKFGQIRNVDIPMLDPYREDMSGNHFSTFSFGGH--------LNFEAFVQYVDHTGFLKAMEALRGMKLLFR----GDDGKA---VACSIKVTFDTTKHLSESSLKKRQQ 271

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BLAST of A-kinase anchor protein 17A vs. Ensembl Xenopus
Match: elavl3 (ELAV like neuron-specific RNA binding protein 3 [Source:Xenbase;Acc:XB-GENE-490864])

HSP 1 Score: 115.161 bits (287), Expect = 8.209e-27
Identity = 78/268 (29.10%), Postives = 138/268 (51.49%), Query Frame = 1

Query:    7 KMVIFIN*AKIPVFKIFKNEVLSNWELLEKIHLLVTPYSFLQLKVTLNTVDGIQLEGETETKSDCKKIVNLLQDMKFKISGIPEYFHISASIYASNITNKNEFSKKYHEARNSDPNI--DRLDTLHIKGLPTLWFSDKNAEGDFKNKPVQQIVESVFSKFGSIRNMYIPINNPLFSNTDGGFNSIVSINSSKIDAVTTILTFEAFIQYKSYKDLLNAISHLKNRKLVFK--DGKFGDSSNSFNLFNAEIVIDFDQSDCLSDYSIRKRN 798
            KM+I +    +P  K    + +SNWE++E++  +V  + F  L+++ +T+D I+ EGE E KS  K  +  L     K+SG  +   + A  Y  +   ++++   + +A++ + ++  +R DT+H++GLP  WF+ K++  +   KP + ++  VF+ FG IR + IP+ +P      G      S            L FEA++QYK Y   + A++ L+  KL++K  DGK              I + FD +  LS+ SI+KR 
Sbjct:   29 KMIISVA---LPQLKQ-PGKSISNWEVMERLKGMVNNHQFSTLRISKSTMDFIRFEGEVENKSLVKTFLAALDGKSIKLSGFSDILKVRAVEYKLDFPTRHDWDSFFRDAKDMNESLPGERPDTIHLEGLPCKWFALKDSGSE---KPNEDVLIKVFNLFGEIRMVDIPMLDPYREEMTGRSFHTFSFGGH--------LNFEAYVQYKEYVGFVKAMNALRGMKLMYKGEDGK---------AVACNIKVSFDSTKHLSEASIKKRQ 272

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BLAST of A-kinase anchor protein 17A vs. Ensembl Xenopus
Match: ENSXETT00000045616.1 (pep primary_assembly:Xenopus_tropicalis_v9.1:8:38410426:38411389:1 gene:ENSXETG00000002159.1 transcript:ENSXETT00000045616.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 88.1965 bits (217), Expect = 7.426e-19
Identity = 73/269 (27.14%), Postives = 124/269 (46.10%), Query Frame = 1

Query:   70 LSNWELLEKIHLLVTPYSFLQLKVTLNTVDGIQLEGETETKSDCKKIVNLLQDMKFKISGIPEYFHISASIYASNITNKNEFS----KKYHEARNSDPNIDRLDTLHIKGLPTLWFSDKNAEGDFKNKPVQQIVESVFSKFGSIRNMYIPINNPLFSNTDGGFNSIVSINSSKIDAVTTILTFEAFIQYKSYKDLLNAISHLKNRKLVFKDGKFGDSSNSFNLFNAEIVIDFDQSDCLSDYSIRKRNKSIKEYFMRIKENSLKEQKKKE 864
            + N E+LE++  LV P  F  LKV  NT + I  EGE +TK   + ++  L     +IS I +   I     + ++ ++ E      K   ++ N   N      + ++GLP  WFS  +   +   KP + ++ S F K+G + N+ IP+ +P      G  N           ++  + TF+AF+QY+     +NAI  L+  KL++       SS     F  +I +  D     S+ +I KRN        R+   +L++Q+K+E
Sbjct:   45 IQNREILEQLKNLVDPEHFSSLKVLRNTKEFILFEGEADTKILAQVLLEKLNGKMLQISSIQDLLSIDVMEVSLDLPSEEELQIFMLKPEGDSENDSENHMITPAICLEGLPCKWFSAGSVSTE---KPSEDVLRSAFEKYGKLSNLDIPMLDPYREEVVGNCNL----------SLGGLQTFKAFLQYEDISSSMNAIHALRGMKLMY-------SSEDGKCFACDIKVSIDTIH-FSEEAISKRNAE------RLHLQALEQQRKQE 286

[Close]

BLAST of A-kinase anchor protein 17A vs. Ensembl Mouse
Match: Akap17b (A kinase (PRKA) anchor protein 17B [Source:MGI Symbol;Acc:MGI:2443758])

HSP 1 Score: 101.293 bits (251), Expect = 3.400e-22
Identity = 73/249 (29.32%), Postives = 126/249 (50.60%), Query Frame = 1

Query:   70 LSNWELLEKIHLLVTPYSFLQLKVTLNTVDGIQLEGETETKSDCKKIVNLLQDMKFKISGIPEYFHISASIYASNITNKNEFSKKYHEAR----NSDPNIDR-LDTLHIKGLPTLWFSDKNAEGDFKNKPVQQIVESVFSKFGSIRNMYIPINNPLFSNTDGGFNSIVSINSSKIDAVTTILTFEAFIQYKSYKDLLNAISHLKNRKLVFKDGKFGDSSNSFNLFNAEIVIDFDQSDCLSDYSIRKRNK 801
             SNWE+L+++  L+ P  F  ++++ +T D I+ EGE ET+S  + +   L     K++G+         + A++   + E   K  EA       + + D+  D+++ +GLP  WF+ K + G+   KP ++I+  VF  FG I+N+ IP+ +P      GG  S   +N         + TFEAFIQY+   D + A+  L+  KL+ K    GD   +       I + FD +   S+ +I++RN+
Sbjct:   45 FSNWEVLDQLKSLICPDQFTTVRLSKSTKDFIRFEGEAETRSLVQILKAKLHGKIIKLNGL----KTDLKVVATDAQGEWEHFPKEKEASVIEGAEEQDHDKGPDSIYFEGLPCKWFAPKGSSGE---KPCEEILRVVFESFGKIKNVDIPMLDPYREVMTGG--SFGGLNFG-------LQTFEAFIQYQESTDFIKAMESLRGMKLMLK----GDDGKA---LACNIKVMFDTTKHFSEGAIQRRNQ 270

[Close]

BLAST of A-kinase anchor protein 17A vs. UniProt/SwissProt
Match: sp|Q02040|AK17A_HUMAN (A-kinase anchor protein 17A OS=Homo sapiens OX=9606 GN=AKAP17A PE=1 SV=2)

HSP 1 Score: 122.865 bits (307), Expect = 1.336e-28
Identity = 75/247 (30.36%), Postives = 129/247 (52.23%), Query Frame = 1

Query:   70 LSNWELLEKIHLLVTPYSFLQLKVTLNTVDGIQLEGETETKSDCKKIVNLLQDMKFKISGIPEYFHISASIYASNITNKNEFSKKYHEARNSDPNI--DRLDTLHIKGLPTLWFSDKNAEGDFKNKPVQQIVESVFSKFGSIRNMYIPINNPLFSNTDGGFNSIVSINSSKIDAVTTILTFEAFIQYKSYKDLLNAISHLKNRKLVFK--DGKFGDSSNSFNLFNAEIVIDFDQSDCLSDYSIRKRN 798
            +SNWE++E++  +V  + F  L+++ +T+D I+ EGE E KS  K  +  L     K+SG  +   + A+ +  +   ++++   + +A++ +  +  +R DT+H++GLP  WF+ K +  +   KP + ++  VF KFG IRN+ IP+ +P      G      S            L FEA++QY+ Y   + A+S L+  KL++K  DGK              I + FD +  LSD SI+KR 
Sbjct:   46 ISNWEVMERLKGMVQNHQFSTLRISKSTMDFIRFEGEVENKSLVKSFLACLDGKTIKLSGFSDILKVRAAEFKIDFPTRHDWDSFFRDAKDMNETLPGERPDTIHLEGLPCKWFALKESGSE---KPSEDVLVKVFEKFGEIRNVDIPMLDPYREEMTGRNFHTFSFGGH--------LNFEAYVQYREYMGFIQAMSALRGMKLMYKGEDGK---------AVACNIKVSFDSTKHLSDASIKKRQ 272

[Close]

BLAST of A-kinase anchor protein 17A vs. UniProt/SwissProt
Match: sp|A2A3V1|AK17B_MOUSE (A-kinase anchor protein 17B OS=Mus musculus OX=10090 GN=Akap17b PE=1 SV=2)

HSP 1 Score: 101.293 bits (251), Expect = 2.379e-21
Identity = 73/249 (29.32%), Postives = 126/249 (50.60%), Query Frame = 1

Query:   70 LSNWELLEKIHLLVTPYSFLQLKVTLNTVDGIQLEGETETKSDCKKIVNLLQDMKFKISGIPEYFHISASIYASNITNKNEFSKKYHEAR----NSDPNIDR-LDTLHIKGLPTLWFSDKNAEGDFKNKPVQQIVESVFSKFGSIRNMYIPINNPLFSNTDGGFNSIVSINSSKIDAVTTILTFEAFIQYKSYKDLLNAISHLKNRKLVFKDGKFGDSSNSFNLFNAEIVIDFDQSDCLSDYSIRKRNK 801
             SNWE+L+++  L+ P  F  ++++ +T D I+ EGE ET+S  + +   L     K++G+         + A++   + E   K  EA       + + D+  D+++ +GLP  WF+ K + G+   KP ++I+  VF  FG I+N+ IP+ +P      GG  S   +N         + TFEAFIQY+   D + A+  L+  KL+ K    GD   +       I + FD +   S+ +I++RN+
Sbjct:   45 FSNWEVLDQLKSLICPDQFTTVRLSKSTKDFIRFEGEAETRSLVQILKAKLHGKIIKLNGL----KTDLKVVATDAQGEWEHFPKEKEASVIEGAEEQDHDKGPDSIYFEGLPCKWFAPKGSSGE---KPCEEILRVVFESFGKIKNVDIPMLDPYREVMTGG--SFGGLNFG-------LQTFEAFIQYQESTDFIKAMESLRGMKLMLK----GDDGKA---LACNIKVMFDTTKHFSEGAIQRRNQ 270

[Close]

BLAST of A-kinase anchor protein 17A vs. TrEMBL
Match: R7U5K4 (Uncharacterized protein (Fragment) OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_44731 PE=4 SV=1)

HSP 1 Score: 142.124 bits (357), Expect = 4.696e-34
Identity = 84/258 (32.56%), Postives = 134/258 (51.94%), Query Frame = 1

Query:   34 KIPVFKIFKNEVLSNWELLEKIHLLVTPYSFLQLKVTLNTVDGIQLEGETETKSDCKKIVNLLQDMKFKISGIPEYFHISASIYASNITNKNEFSKKYHEARNSD---PNIDRLDTLHIKGLPTLWFSDKNAEGDFKNKPVQQIVESVFSKFGSIRNMYIPINNPLFSNTDGGFNSIVSINSSKIDAVTTILTFEAFIQYKSYKDLLNAISHLKNRKLVFKDGKFGDSSNSFNLFNAEIVIDFDQSDCLSDYSIRKRN 798
            ++P  K   ++ +SNWEL+EKI  +V P  F+ LKV  +T++ ++ EGE E K   K +V  L     K+ G P+   + A+       +++++   + +A+N +   P  +R DT+H + LP+ WF+D    GD   KP + ++  VF  FG +R + IP  +P          S  S+ S      +  L FEAF+QYK Y     A++ LK  KLVF +        +  +F A I ++FD S  LSD +I+KR 
Sbjct:   35 QLPQLKGNGSKTISNWELMEKIKKMVKPEQFITLKVAKSTLEFVRFEGEIENKIKVKNLVARLDSKTIKLGGFPDALKVRAAEAKIPFPSRHDWDSYFRDAKNMNEMKPG-ERPDTVHFRDLPSRWFADSKGGGD---KPSEAVLRKVFETFGEVRCVDIPTLDPYRKEMTMSAPSFTSVKS--FSTFSQDLVFEAFVQYKEYIGFCKAMTALKGMKLVFME-------TAERIFAASIKVEFDTSKHLSDKNIKKRR 279

[Close]

BLAST of A-kinase anchor protein 17A vs. TrEMBL
Match: C3XWC1 (Uncharacterized protein OS=Branchiostoma floridae OX=7739 GN=BRAFLDRAFT_63690 PE=4 SV=1)

HSP 1 Score: 142.51 bits (358), Expect = 1.461e-33
Identity = 87/248 (35.08%), Postives = 136/248 (54.84%), Query Frame = 1

Query:   70 LSNWELLEKIHLLVTPYSFLQLKVTLNTVDGIQLEGETETKSDCKKIVNLLQDMKFKISGIPEYFHISASIYASNITNKNEFSKKYHEARNSDPNI--DRLDTLHIKGLPTLWFSDKNAEGDFKNKPVQQIVESVFSKFGSIRNMYIPINNPLFS-NTDGGFNSIVSINSSKIDAVTTILTFEAFIQYKSYKDLLNAISHLKNRKLVFK--DGKFGDSSNSFNLFNAEIVIDFDQSDCLSDYSIRKRN 798
            +SNWE++E+I  +V P +F  LKV  +T++ I+ EGE E KS  K +V  L     K+SG  E   + A+        ++E+   + +A+  +  +  +R DT+H +GLP  WF+   A  D  +K  + +++ VF+ FG +R + IP+ +P    N  G FN+  S +S     + T LTFEA++Q+K Y   +N + HLK  KL++K  DGK            A   +DFD+S  LSD +IRKR 
Sbjct:   46 ISNWEVMERIKAMVKPDAFSLLKVVKSTLEFIRFEGEAEAKSLLKTMVARLDGKTIKLSGFSEMLKVRAAEAKVVFPTRHEWDSHFRDAKFMNETVAGERPDTVHFEGLPCKWFT---ASKD-SDKASENVLKKVFATFGEVRRVDIPMLDPYRQENKTGNFNTFSSFSS-----LGTSLTFEAYVQFKEYIGFVNCMEHLKGMKLMYKGDDGKAA---------TANFKVDFDKSGHLSDKAIRKRR 275

[Close]

BLAST of A-kinase anchor protein 17A vs. TrEMBL
Match: A0A4D5RVI9 (Putative a-kinase anchor protein 17a (Fragment) OS=Ixodes scapularis OX=6945 PE=4 SV=1)

HSP 1 Score: 139.043 bits (349), Expect = 4.513e-32
Identity = 78/247 (31.58%), Postives = 133/247 (53.85%), Query Frame = 1

Query:   70 LSNWELLEKIHLLVTPYSFLQLKVTLNTVDGIQLEGETETKSDCKKIVNLLQDMKFKISGIPEYFHISASIYASNITNKNEFSKKYHEARNSD---PNIDRLDTLHIKGLPTLWFSDKNAEGDFKNKPVQQIVESVFSKFGSIRNMYIPINNPLFSNTDGGFNSIVSINSSKIDAVTTILTFEAFIQYKSYKDLLNAISHLKNRKLVFKDGKFGDSSNSFNLFNAEIVIDFDQSDCLSDYSIRKRNK 801
            +SNWE++EK+   + P  F  LK++  T++ I+ EGE E KS  K IV+ L+    K+SG P+   I A+        ++++   + +AR+ D   P  +R DT++++GLP  WF+DK  + D   +P + +V   FS  G +R + IP+ +P   + +     I + + S+       LTF+ ++QYK Y   + A+  L+  KL++K       +     F A I +DFD+S  LS+ SI +R +
Sbjct:   46 ISNWEVMEKLRQAIRPEEFTTLKISKTTLEFIRFEGEVENKSALKTIVSRLEGSTVKLSGFPDNLRIRAAEAKVPFPTRHDWDSYFRDARDMDEMKPG-ERPDTIYVQGLPCKWFADKRRDPD---RPSELLVRQAFSSLGEVRCLDIPLLDPYQKDAEAAVGKISTFSFSQ------DLTFDVYVQYKEYIGFVKAMDSLRGMKLMYK-------TPEGRAFAANIKVDFDKSQHLSEESITRRQQ 275

[Close]

BLAST of A-kinase anchor protein 17A vs. TrEMBL
Match: G3MGK8 (Uncharacterized protein (Fragment) OS=Amblyomma maculatum OX=34609 PE=2 SV=1)

HSP 1 Score: 138.272 bits (347), Expect = 5.027e-32
Identity = 75/247 (30.36%), Postives = 134/247 (54.25%), Query Frame = 1

Query:   70 LSNWELLEKIHLLVTPYSFLQLKVTLNTVDGIQLEGETETKSDCKKIVNLLQDMKFKISGIPEYFHISASIYASNITNKNEFSKKYHEARNSD---PNIDRLDTLHIKGLPTLWFSDKNAEGDFKNKPVQQIVESVFSKFGSIRNMYIPINNPLFSNTDGGFNSIVSINSSKIDAVTTILTFEAFIQYKSYKDLLNAISHLKNRKLVFKDGKFGDSSNSFNLFNAEIVIDFDQSDCLSDYSIRKRNK 801
            +S+WE++EK+ L + P  F  LK++  T++ I+ EGE E ++  K +V  L++   K+SG PE   + A+    +   ++++   + +A+  D   P  +R DT++++GLP  WF+DK  + D   +P + +V  VFS  G +R + IP+ +P   + +     I + + S+       LTF+ ++QY  Y   + A+  L+  KL+ K       +     F A I +DFD+S  LSD SI++R +
Sbjct:   52 ISSWEVMEKLRLAIKPDEFTTLKISKTTLEFIRFEGEVENRNALKAVVARLENSTVKLSGFPENLRVRAAEAKVSFPTRHDWDSYFRDAKGMDEMKPG-ERPDTIYVQGLPCKWFADKRRDAD---RPSEHLVRQVFSGPGPVRRLDIPLLDPYQKDAEAAVGRISTFSFSQ------ELTFDVYVQYMEYMGFVKAMDSLRGMKLMLK-------TPEGRAFTANIKVDFDKSRHLSDDSIQRRQQ 281

[Close]

BLAST of A-kinase anchor protein 17A vs. TrEMBL
Match: V5HU27 (Putative a-kinase anchor protein 17a OS=Ixodes ricinus OX=34613 PE=2 SV=1)

HSP 1 Score: 139.428 bits (350), Expect = 1.188e-31
Identity = 78/247 (31.58%), Postives = 133/247 (53.85%), Query Frame = 1

Query:   70 LSNWELLEKIHLLVTPYSFLQLKVTLNTVDGIQLEGETETKSDCKKIVNLLQDMKFKISGIPEYFHISASIYASNITNKNEFSKKYHEARNSD---PNIDRLDTLHIKGLPTLWFSDKNAEGDFKNKPVQQIVESVFSKFGSIRNMYIPINNPLFSNTDGGFNSIVSINSSKIDAVTTILTFEAFIQYKSYKDLLNAISHLKNRKLVFKDGKFGDSSNSFNLFNAEIVIDFDQSDCLSDYSIRKRNK 801
            +SNWE++EK+   + P  F  LK++  T++ I+ EGE E KS  K IV+ L+    K+SG P+   I A+        ++++   + +AR+ D   P  +R DT++++GLP  WF+DK  + D   +P + +V   FS  G +R + IP+ +P   + +     I + + S+       LTF+ ++QYK Y   + A+  L+  KL++K       +     F A I +DFD+S  LS+ SI +R +
Sbjct:   46 ISNWEVMEKLRQAIRPEEFTTLKISKTTLEFIRFEGEVENKSALKTIVSRLEGSTVKLSGFPDNLRIRAAEAKVPFPTRHDWDSYFRDARDMDEMKPG-ERPDTIYVQGLPCKWFADKRRDPD---RPSELLVRQAFSSLGEVRCLDIPLLDPYQKDAEAAVGKISTFSFSQ------DLTFDVYVQYKEYIGFVKAMDSLRGMKLMYK-------TPEGRAFAANIKVDFDKSQHLSEESITRRQQ 275

[Close]

BLAST of A-kinase anchor protein 17A vs. Ensembl Cavefish
Match: akap17a (A-kinase anchoring protein 17A [Source:NCBI gene;Acc:103039535])

HSP 1 Score: 115.931 bits (289), Expect = 2.993e-27
Identity = 75/268 (27.99%), Postives = 139/268 (51.87%), Query Frame = 1

Query:    7 KMVIFIN*AKIPVFKIFKNEVLSNWELLEKIHLLVTPYSFLQLKVTLNTVDGIQLEGETETKSDCKKIVNLLQDMKFKISGIPEYFHISASIYASNITNKNEFSKKYHEARNSDPNI--DRLDTLHIKGLPTLWFSDKNAEGDFKNKPVQQIVESVFSKFGSIRNMYIPINNPLFSNTDG-GFNSIVSINSSKIDAVTTILTFEAFIQYKSYKDLLNAISHLKNRKLVFKDGKFGDSSNSFNLFNAEIVIDFDQSDCLSDYSIRKRNK 801
            KM I +    +P  K+   + +SNWE++E++  +V P  F  L+++ +T+D I+ EGE E +   K  V  L     K+SG  +   + A+    +   ++++   + +A++ +  +  +R DT+H++GLP  WF+ K++  D   +P + +++ VF  FG IRN+ IP+ +P      G  FN+          +    L FE +IQY+ +   + A+  L+  KL++K    GD   +       I ++FD +  LS+ S +KR +
Sbjct:   27 KMTISV---ALPQLKM-PGKSISNWEVMERLKNMVHPELFSSLRISKSTMDFIRFEGEVENRGIVKSFVAKLDGKSIKLSGFTDILKVRAAENKVDFPTRHDWDSFFRDAKDMNETVPGERPDTIHLEGLPCKWFALKDSSSD---RPSEAVLKIVFENFGKIRNVDIPMLDPYREEMTGKNFNTF---------SFGGHLNFEGYIQYEDHTGFVKAMDTLRGMKLMYK----GDDGKA---VACNIKVNFDTTKHLSESSQKKRQQ 271

[Close]

BLAST of A-kinase anchor protein 17A vs. Ensembl Nematostella
Match: EDO47074 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RN51])

HSP 1 Score: 105.531 bits (262), Expect = 1.636e-24
Identity = 75/247 (30.36%), Postives = 122/247 (49.39%), Query Frame = 1

Query:   70 LSNWELLEKIHLLVTPYSFLQLKVTLNTVDGIQLEGETETKSDCKKIVNLLQDMKFKISGIPEYFHISASIYASNITNKNEFSKKYHEAR--NSDPNIDRLDTLHIKGLPTLWFSDKNAEGDFKNKPVQQIVESVFSKFGSIRNMYIPINNPLFSNTDGGFNSIVSINSSKIDA--VTTILTFEAFIQYKSYKDLLNAISHLKNRKLVFKDGKFGDSSNSFNLFNAEIVIDFDQSDCLSDYSIRKRN 798
            +SNWE++EK+  +V P  F  L+V  +T++ I+ E ETETK    K ++ L     K+ G  +   + A          +E+   + +A+  N     +R DT+ IKGLP+ WF+ + + GD   KP +  V SVF  FG IR + IPI +         +   ++ N S+       + L F+ +IQ+K Y+   +A++  K  KLV         S       A I++DFD++  LS  +I  R+
Sbjct:   45 ISNWEVMEKLKAMVAPDQFAVLRVVESTLEMIRFEAETETKGVLSKFIDKLDGNVIKLGGFADPLKVRAKETKLKFPKMHEWDSFFRDAKELNECKPGERPDTITIKGLPSKWFATQQS-GD---KPCENTVISVFQHFGKIRCIDIPILD--------SYRQQITNNKSEFQTFYFGSHLHFDVYIQFKQYQGFTSAMTSFKGMKLVH-------ISEEGRAAAANIMVDFDRTSHLSAKNIEARD 272

[Close]

BLAST of A-kinase anchor protein 17A vs. Ensembl Medaka
Match: akap17a (A-kinase anchoring protein 17A [Source:NCBI gene;Acc:101163620])

HSP 1 Score: 127.872 bits (320), Expect = 2.646e-31
Identity = 83/275 (30.18%), Postives = 144/275 (52.36%), Query Frame = 1

Query:    7 KMVIFIN*AKIPVFKIFKNEVLSNWELLEKIHLLVTPYSFLQLKVTLNTVDGIQLEGETETKSDCKKIVNLLQDMKFKISGIPEYFHISASIYASNITNKNEFSKK------YHEARNSDPNI--DRLDTLHIKGLPTLWFSDKNAEGDFKNKPVQQIVESVFSKFGSIRNMYIPINNPLFSN-TDGGFNSIVSINSSKIDAVTTILTFEAFIQYKSYKDLLNAISHLKNRKLVFK--DGKFGDSSNSFNLFNAEIVIDFDQSDCLSDYSIRKRN 798
            KM + +    +P  K+   + +SNWE++E++  +V P  F  L+++ +T+D I+ EGE E K+  K +++ L     K+SG  +   + A      + NK EF  +      + +A++ +  +  +R DT+H++GLP  WFS K+++  F ++P ++++ +VF  FG +RN+ IP+ +P      D  F++          +    L FEAF+QY+ Y     A+  L+  KL+ K  DGK              I + FD S  LSD +I+KRN
Sbjct:   29 KMTVSVA---LPQLKL-PGKSISNWEVMERVKAMVAPEQFSALRISKSTMDFIRFEGEVENKTVVKGLLSRLDGKTIKLSGFTDVLKVRA------VENKVEFPTRHDWDSFFRDAKDMNETLPGERPDTIHLEGLPCRWFSQKDSQ--FPDRPSEEVLIAVFQTFGKVRNVDIPMLDPYREEMMDKNFSTF---------SFGGHLNFEAFVQYQEYGFFTKAMDTLRGMKLMLKGEDGK---------AVACNIKVTFDTSKHLSDAAIKKRN 273

[Close]

BLAST of A-kinase anchor protein 17A vs. Planmine SMEST
Match: SMESG000071776.1 (SMESG000071776.1)

HSP 1 Score: 373.629 bits (958), Expect = 3.053e-128
Identity = 215/216 (99.54%), Postives = 216/216 (100.00%), Query Frame = 1

Query:  496 MYIPINNPLFSNTDGGFNSIVSINSSKIDAVTTILTFEAFIQYKSYKDLLNAISHLKNRKLVFKDGKFGDSSNSFNLFNAEIVIDFDQSDCLSDYSIRKRNKSIKEYFMRIKENSLKEQKKKECDGILNEKLKSQVVXXXXXXXXXXXXEDFDENAXXXXXXXXXXXXXXXYIGQQKIESVRVLSILYDKLKRQEEADVAKNQELEIEEFKHHKPV 1143
            MYIPINNPLFSNTDGGFNSIVSINSSKIDAVTTILTFEAFIQYKSYKDLLNAISHLKNRKLVFKDGKFGDSSNSFNLFNAEIVIDFDQSDCLSDYSIRKRNKSIKEYFMRIKENSLKEQKKKECDGILNEKLKSQVVKRKIGKKHKQKKEDFDENAKSIKKLKKAVKEEKKYIGQQKIESVRVLSILYDKLKRQEEADVAKNQELEIEEFKHHKP+
Sbjct:    1 MYIPINNPLFSNTDGGFNSIVSINSSKIDAVTTILTFEAFIQYKSYKDLLNAISHLKNRKLVFKDGKFGDSSNSFNLFNAEIVIDFDQSDCLSDYSIRKRNKSIKEYFMRIKENSLKEQKKKECDGILNEKLKSQVVKRKIGKKHKQKKEDFDENAKSIKKLKKAVKEEKKYIGQQKIESVRVLSILYDKLKRQEEADVAKNQELEIEEFKHHKPL 216

HSP 2 Score: 92.8189 bits (229), Expect = 6.106e-21
Identity = 66/66 (100.00%), Postives = 66/66 (100.00%), Query Frame = 3

Query: 1200 LLEDISKKESVELRDPREHQKDXXXXXXXXXXXXXXXXVIKNRFRQITDDSSDKEAAERAHLSEKA 1397
            LLEDISKKESVELRDPREHQKDKLLKRELELRERLMRKVIKNRFRQITDDSSDKEAAERAHLSEKA
Sbjct:  216 LLEDISKKESVELRDPREHQKDKLLKRELELRERLMRKVIKNRFRQITDDSSDKEAAERAHLSEKA 281

The following BLAST results are available for this feature:

BLAST of A-kinase anchor protein 17A vs. Ensembl Human
BLAST of A-kinase anchor protein 17A vs. Ensembl Celegans
BLAST of A-kinase anchor protein 17A vs. Ensembl Fly
BLAST of A-kinase anchor protein 17A vs. Ensembl Zebrafish
BLAST of A-kinase anchor protein 17A vs. Ensembl Xenopus
BLAST of A-kinase anchor protein 17A vs. Ensembl Mouse
BLAST of A-kinase anchor protein 17A vs. UniProt/SwissProt
BLAST of A-kinase anchor protein 17A vs. TrEMBL
BLAST of A-kinase anchor protein 17A vs. Ensembl Cavefish
BLAST of A-kinase anchor protein 17A vs. Ensembl Sea Lamprey
BLAST of A-kinase anchor protein 17A vs. Ensembl Yeast
BLAST of A-kinase anchor protein 17A vs. Ensembl Nematostella
BLAST of A-kinase anchor protein 17A vs. Ensembl Medaka
BLAST of A-kinase anchor protein 17A vs. Planmine SMEST

BLAST of A-kinase anchor protein 17A vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 3


Match Name	E-value	Identity	Description
AKAP17A	2.621e-31	30.36	A-kinase anchoring protein 17A [Source:HGNC Symbol...	[more]
AKAP17A	1.739e-30	30.36	A-kinase anchoring protein 17A [Source:HGNC Symbol...	[more]
AKAP17A	2.783e-29	30.36	A-kinase anchoring protein 17A [Source:HGNC Symbol...	[more]

BLAST of A-kinase anchor protein 17A vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 3


Match Name	E-value	Identity	Description
cux-7	6.459e-22	26.61	Clk-2 Upstream, human gene XE7 related [Source:Un...	[more]
cux-7	6.459e-22	26.61	Clk-2 Upstream, human gene XE7 related [Source:Un...	[more]
cux-7	6.459e-22	26.61	Clk-2 Upstream, human gene XE7 related [Source:Un...	[more]

BLAST of A-kinase anchor protein 17A vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3


Match Name	E-value	Identity	Description
Xe7	2.784e-31	27.72	gene:FBgn0010772 transcript:FBtr0334952	[more]
Xe7	2.654e-30	25.89	gene:FBgn0010772 transcript:FBtr0334951	[more]
Xe7	2.934e-30	25.89	gene:FBgn0010772 transcript:FBtr0078728	[more]

BLAST of A-kinase anchor protein 17A vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1


Match Name	E-value	Identity	Description
akap17a	1.283e-33	29.18	A kinase (PRKA) anchor protein 17A [Source:ZFIN;Ac...	[more]

BLAST of A-kinase anchor protein 17A vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2


Match Name	E-value	Identity	Description
elavl3	8.209e-27	29.10	ELAV like neuron-specific RNA binding protein 3 [S...	[more]
ENSXETT00000045616.1	7.426e-19	27.14	pep primary_assembly:Xenopus_tropicalis_v9.1:8:384...	[more]

BLAST of A-kinase anchor protein 17A vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 1


Match Name	E-value	Identity	Description
Akap17b	3.400e-22	29.32	A kinase (PRKA) anchor protein 17B [Source:MGI Sym...	[more]

BLAST of A-kinase anchor protein 17A vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 2


Match Name	E-value	Identity	Description
sp\|Q02040\|AK17A_HUMAN	1.336e-28	30.36	A-kinase anchor protein 17A OS=Homo sapiens OX=960...	[more]
sp\|A2A3V1\|AK17B_MOUSE	2.379e-21	29.32	A-kinase anchor protein 17B OS=Mus musculus OX=100...	[more]

BLAST of A-kinase anchor protein 17A vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
R7U5K4	4.696e-34	32.56	Uncharacterized protein (Fragment) OS=Capitella te...	[more]
C3XWC1	1.461e-33	35.08	Uncharacterized protein OS=Branchiostoma floridae ...	[more]
A0A4D5RVI9	4.513e-32	31.58	Putative a-kinase anchor protein 17a (Fragment) OS...	[more]
G3MGK8	5.027e-32	30.36	Uncharacterized protein (Fragment) OS=Amblyomma ma...	[more]
V5HU27	1.188e-31	31.58	Putative a-kinase anchor protein 17a OS=Ixodes ric...	[more]

BLAST of A-kinase anchor protein 17A vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1


Match Name	E-value	Identity	Description
akap17a	2.993e-27	27.99	A-kinase anchoring protein 17A [Source:NCBI gene;A...	[more]

BLAST of A-kinase anchor protein 17A vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of A-kinase anchor protein 17A vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of A-kinase anchor protein 17A vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1


Match Name	E-value	Identity	Description
EDO47074	1.636e-24	30.36	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of A-kinase anchor protein 17A vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1


Match Name	E-value	Identity	Description
akap17a	2.646e-31	30.18	A-kinase anchoring protein 17A [Source:NCBI gene;A...	[more]

BLAST of A-kinase anchor protein 17A vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1


Match Name	E-value	Identity	Description
SMESG000071776.1	3.053e-128	99.54	SMESG000071776.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30030822 ID=SMED30030822|Name=A-kinase anchor protein 17A|organism=Schmidtea mediterranea sexual|type=transcript|length=1407bp
TGCAAGAAAATGGTGATTTTTATCAATTAAGCGAAAATTCCGGTATTTAA
GATTTTTAAAAATGAAGTACTTTCTAACTGGGAATTACTAGAAAAAATTC
ATTTGTTAGTTACGCCTTATTCTTTTTTACAGCTGAAAGTCACTTTAAAT
ACAGTTGATGGAATTCAACTTGAAGGGGAAACTGAAACCAAAAGTGATTG
TAAGAAAATTGTTAATTTGTTACAAGATATGAAGTTTAAAATTAGCGGTA
TTCCCGAATATTTCCATATTTCAGCATCTATTTATGCAAGTAATATCACA
AATAAGAATGAATTTAGTAAAAAATATCACGAAGCTCGTAATTCTGATCC
AAATATTGACAGGTTAGATACTTTACATATTAAAGGTTTGCCAACATTAT
GGTTTTCTGATAAAAATGCTGAAGGGGATTTTAAGAATAAGCCAGTTCAA
CAAATTGTTGAATCTGTTTTTTCTAAATTTGGTAGTATTCGTAATATGTA
TATTCCAATAAATAATCCACTTTTCTCAAATACTGACGGTGGTTTTAACT
CAATTGTATCTATTAATTCATCTAAAATTGATGCTGTAACTACAATTCTT
ACTTTTGAAGCTTTTATTCAGTATAAATCTTATAAAGACTTGTTGAATGC
AATCAGTCATTTGAAAAATAGAAAGCTTGTATTTAAAGATGGTAAATTTG
GTGACAGTTCGAATTCTTTTAACTTGTTCAATGCCGAAATTGTAATTGAT
TTTGATCAGTCAGATTGTTTGTCAGATTATTCAATAAGAAAACGAAACAA
ATCTATTAAAGAATATTTTATGAGAATAAAAGAAAACAGTTTAAAAGAGC
AAAAAAAAAAGGAGTGTGATGGAATATTAAATGAAAAATTAAAATCGCAG
GTGGTTAAACGAAAAATTGGGAAAAAACATAAACAAAAGAAAGAAGATTT
TGATGAAAATGCAAAATCAATAAAGAAGCTCAAAAAAGCAGTTAAAGAAG
AGAAAAAATATATCGGTCAACAGAAAATAGAATCTGTTCGAGTTTTGTCT
ATATTGTATGATAAGTTAAAGCGTCAGGAAGAAGCGGATGTAGCGAAAAA
TCAAGAATTAGAAATCGAAGAGTTTAAACATCATAAACCGGTGACATTTT
ATTCTTAATCTTGGCGATGCCTGTAGTGAATAGAATGGTTTTATTGTAGT
TATTGGAGGATATTTCTAAAAAAGAATCCGTAGAATTGAGAGATCCTCGC
GAGCATCAGAAAGATAAATTATTGAAAAGAGAGCTGGAATTACGCGAGCG
TTTAATGCGGAAAGTTATAAAAAATCGATTTCGACAAATTACAGACGATT
CCAGCGACAAGGAGGCTGCGGAGAGGGCTCATTTGTCAGAAAAGGCAGAT
CGGAAGA

protein sequence of SMED30030822-orf-1

>SMED30030822-orf-1 ID=SMED30030822-orf-1|Name=SMED30030822-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=310bp
MKFKISGIPEYFHISASIYASNITNKNEFSKKYHEARNSDPNIDRLDTLH
IKGLPTLWFSDKNAEGDFKNKPVQQIVESVFSKFGSIRNMYIPINNPLFS
NTDGGFNSIVSINSSKIDAVTTILTFEAFIQYKSYKDLLNAISHLKNRKL
VFKDGKFGDSSNSFNLFNAEIVIDFDQSDCLSDYSIRKRNKSIKEYFMRI
KENSLKEQKKKECDGILNEKLKSQVVKRKIGKKHKQKKEDFDENAKSIKK
LKKAVKEEKKYIGQQKIESVRVLSILYDKLKRQEEADVAKNQELEIEEFK
HHKPVTFYS*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **molecular function**
Term	Definition
GO:0016301	kinase activity
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0051018	protein kinase A binding

Vocabulary: **biological process**
Term	Definition
GO:0016310	phosphorylation
GO:0006355	regulation of transcription, DNA-templated
GO:0006397	mRNA processing
GO:0007165	signal transduction
GO:0008380	RNA splicing
GO:0042113	B cell activation
GO:0043484	regulation of RNA splicing

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000020	protonephridia
PLANA:0000099	neuron
PLANA:0000463	cholinergic neuron

Vocabulary: **INTERPRO**
Term	Definition
IPR035979	RBD_domain_sf
IPR012677	Nucleotide-bd_a/b_plait_sf

Vocabulary: **cellular component**
Term	Definition
GO:0005634	nucleus
GO:0005681	spliceosomal complex
GO:0005829	cytosol
GO:0016607	nuclear speck

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 238..258
None	No IPR available	COILS	Coil	Coil	coord: 277..297
None	No IPR available	PANTHER	PTHR12484:SF4	A KINASE (PRKA) ANCHOR PROTEIN 17A	coord: 4..295
None	No IPR available	PANTHER	PTHR12484	B-LYMPHOCYTE ANTIGEN-RELATED	coord: 4..295
IPR035979	RNA-binding domain superfamily	SUPERFAMILY	SSF54928	RNA-binding domain, RBD	coord: 75..150

Main menu

A-kinase anchor protein 17A

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 16

Owlery

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