Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial

Overview
NameMethylmalonic aciduria and homocystinuria type D-like protein, mitochondrial
Smed IDSMED30030643
Length (bp)1051
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial (SMED30030643) t-SNE clustered cells

Violin plots show distribution of expression levels for Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial (SMED30030643) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial (SMED30030643) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial (SMED30030643) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30030643

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
pharynxSMED30030643SMESG000030431.1 dd_Smed_v4_2046_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
protonephridiaSMED30030643SMESG000030431.1 dd_Smed_v4_2046_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30030643SMESG000030431.1 dd_Smed_v4_2046_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30030643SMESG000030431.1 dd_Smed_v6_2046_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. Ensembl Human
Match: MMADHC (metabolism of cobalamin associated D [Source:HGNC Symbol;Acc:HGNC:25221])

HSP 1 Score: 144.436 bits (363), Expect = 4.433e-40
Identity = 74/181 (40.88%), Postives = 102/181 (56.35%), Query Frame = 1 
Query:  370 INQFQS------EEIKYDDFSFNSGRLEYTIHSCFKPLRRDLKDLFPDRDIMSEESPLSVVCLNHHTNANMSTWDSSVAEERIALANLVVNSSIEICKSFKNCGYWADFIDPYSGAPYYGPHTNDTLFETDPRMRNFGLEIQDLGCCKVLSHPIWKENVFCGLIFTNA-PADHPMLNLLHN 891
            +N+FQ       +EI   +  F S R+E  I +C + LR+D + LFP+         L ++ +   T  +M+ W   V  ER  L    +N + EIC + +  GYWADFIDP SG  ++GP+TN+TLFETD R R+ G  + DLGCCKV+ H +W  +V  G IFTNA P  H M  L  N
Sbjct:  120 VNEFQGNDAPVEQEINSAETYFESARVECAIQTCPELLRKDFESLFPE----VANGKLMILTVTQKTKNDMTVWSEEVEIEREVLLEKFINGAKEICYALRAEGYWADFIDPSSGLAFFGPYTNNTLFETDERYRHLGFSVDDLGCCKVIRHSLWGTHVVVGSIFTNATPDSHIMKKLSGN 296
[Close]
BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. Ensembl Human
Match: MMADHC (metabolism of cobalamin associated D [Source:HGNC Symbol;Acc:HGNC:25221])

HSP 1 Score: 144.436 bits (363), Expect = 4.433e-40
Identity = 74/181 (40.88%), Postives = 102/181 (56.35%), Query Frame = 1 
Query:  370 INQFQS------EEIKYDDFSFNSGRLEYTIHSCFKPLRRDLKDLFPDRDIMSEESPLSVVCLNHHTNANMSTWDSSVAEERIALANLVVNSSIEICKSFKNCGYWADFIDPYSGAPYYGPHTNDTLFETDPRMRNFGLEIQDLGCCKVLSHPIWKENVFCGLIFTNA-PADHPMLNLLHN 891
            +N+FQ       +EI   +  F S R+E  I +C + LR+D + LFP+         L ++ +   T  +M+ W   V  ER  L    +N + EIC + +  GYWADFIDP SG  ++GP+TN+TLFETD R R+ G  + DLGCCKV+ H +W  +V  G IFTNA P  H M  L  N
Sbjct:  120 VNEFQGNDAPVEQEINSAETYFESARVECAIQTCPELLRKDFESLFPE----VANGKLMILTVTQKTKNDMTVWSEEVEIEREVLLEKFINGAKEICYALRAEGYWADFIDPSSGLAFFGPYTNNTLFETDERYRHLGFSVDDLGCCKVIRHSLWGTHVVVGSIFTNATPDSHIMKKLSGN 296
[Close]
BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. Ensembl Human
Match: MMADHC (metabolism of cobalamin associated D [Source:HGNC Symbol;Acc:HGNC:25221])

HSP 1 Score: 127.487 bits (319), Expect = 2.828e-33
Identity = 76/215 (35.35%), Postives = 104/215 (48.37%), Query Frame = 1 
Query:  370 INQFQS------EEIKYDDFSFNSGRLEYTIHSCFKPLRRDLKDLFPDRDIMSEESPLSVVCLNHHTNANMSTWDSSVAEERIAL--------------------ANLV--------------VNSSIEICKSFKNCGYWADFIDPYSGAPYYGPHTNDTLFETDPRMRNFGLEIQDLGCCKVLSHPIWKENVFCGLIFTNA-PADHPMLNLLHN 891
            +N+FQ       +EI   +  F S R+E  I +C + LR+D + LFP+         L ++ +   T  +M+ W   V  ER  L                     NL               +N + EIC + +  GYWADFIDP SG  ++GP+TN+TLFETD R R+ G  + DLGCCKV+ H +W  +V  G IFTNA P  H M  L  N
Sbjct:  120 VNEFQGNDAPVEQEINSAETYFESARVECAIQTCPELLRKDFESLFPE----VANGKLMILTVTQKTKNDMTVWSEEVEIEREVLLEKTESLSPRPECCGMISAHCNLCLPGSSNSSASASRFINGAKEICYALRAEGYWADFIDPSSGLAFFGPYTNNTLFETDERYRHLGFSVDDLGCCKVIRHSLWGTHVVVGSIFTNATPDSHIMKKLSGN 330
[Close]
BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. Ensembl Celegans
Match: Y76A2B.5 (pep chromosome:WBcel235:III:13546889:13549020:-1 gene:WBGene00013577.1 transcript:Y76A2B.5.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y76A2B.5)

HSP 1 Score: 129.413 bits (324), Expect = 6.360e-35
Identity = 64/171 (37.43%), Postives = 95/171 (55.56%), Query Frame = 1 
Query:  358 QIDVINQFQSEEIKYDDFSFNSGRLEYTIHSCFKP--LRRDLKDLFPDRDIMSEESPLSVVCLNHHTNANMSTWDSSVAEERIALANLVVNSSIEICKSFKNCGYWADFIDPYSGAPYYGPHTNDTLFETDPRMRNFGLEIQDLGCCKVLSHPIWKENVFCGLIFTNAPAD 864
            ++D  +  Q +E   ++   N+  +E  + +   P  L++++K LFP  +     + ++V  L   +  +M  W  ++ EER  L    + S+  IC +    GYWADFIDP SG PY G +TN TLFET+   +  G +I+DLGCCKVL H  W  N F G IFT+AP D
Sbjct:   97 EVDRTHLAQLKEEAMEEIQANAADVEIELSAIEAPKLLKKEMKYLFPQMETQKMNN-VTVFNLTQKSEFDMKAWSEAMEEEREKLTASFIMSANAICSTLHRFGYWADFIDPSSGRPYMGDYTNHTLFETNDAYKQMGFKIEDLGCCKVLQHACWGSNAFVGTIFTDAPVD 266
[Close]
BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. Ensembl Celegans
Match: Y76A2B.5 (pep chromosome:WBcel235:III:13546889:13549005:-1 gene:WBGene00013577.1 transcript:Y76A2B.5.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y76A2B.5)

HSP 1 Score: 129.413 bits (324), Expect = 6.360e-35
Identity = 64/171 (37.43%), Postives = 95/171 (55.56%), Query Frame = 1 
Query:  358 QIDVINQFQSEEIKYDDFSFNSGRLEYTIHSCFKP--LRRDLKDLFPDRDIMSEESPLSVVCLNHHTNANMSTWDSSVAEERIALANLVVNSSIEICKSFKNCGYWADFIDPYSGAPYYGPHTNDTLFETDPRMRNFGLEIQDLGCCKVLSHPIWKENVFCGLIFTNAPAD 864
            ++D  +  Q +E   ++   N+  +E  + +   P  L++++K LFP  +     + ++V  L   +  +M  W  ++ EER  L    + S+  IC +    GYWADFIDP SG PY G +TN TLFET+   +  G +I+DLGCCKVL H  W  N F G IFT+AP D
Sbjct:   97 EVDRTHLAQLKEEAMEEIQANAADVEIELSAIEAPKLLKKEMKYLFPQMETQKMNN-VTVFNLTQKSEFDMKAWSEAMEEEREKLTASFIMSANAICSTLHRFGYWADFIDPSSGRPYMGDYTNHTLFETNDAYKQMGFKIEDLGCCKVLQHACWGSNAFVGTIFTDAPVD 266
[Close]
BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. Ensembl Fly
Match: CG12118 (gene:FBgn0030101 transcript:FBtr0071339)

HSP 1 Score: 67.3958 bits (163), Expect = 2.023e-12
Identity = 39/144 (27.08%), Postives = 67/144 (46.53%), Query Frame = 1 
Query:  427 RLEYTIHSCFKPLRRDLKDLFPDRDIMSEESPLSVVCLNHHTNANMSTWDSSVAEERIALANLVVNSSIEICKSFKNCGYWADFIDPYSGAPYYGPHTNDTLFETDPRMRNFGLEIQDLGCCKVLSHPIWKENVFCGLIFTNAP 858
            RLE+T   C   +R  L ++FP   +  +   ++++ L+H  +  M              A   V ++ E+C    + GYWADF++P+SG P++ P     L+  D R R   + + +   C V+S        F G I++ AP
Sbjct:  135 RLEFTCCKCPLLIRVPLLEIFPVPVVAQQCINITMLVLSHEGDIEMG-------------AAKFVLAAREMCDRLLSYGYWADFMNPFSGRPFFLPREGANLYRLDSRFRGLNMRLSEQNRCTVISAEKNDSTRFSGTIYSTAP 265
[Close]
BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. Ensembl Fly
Match: CG12118 (gene:FBgn0030101 transcript:FBtr0071340)

HSP 1 Score: 67.3958 bits (163), Expect = 2.023e-12
Identity = 39/144 (27.08%), Postives = 67/144 (46.53%), Query Frame = 1 
Query:  427 RLEYTIHSCFKPLRRDLKDLFPDRDIMSEESPLSVVCLNHHTNANMSTWDSSVAEERIALANLVVNSSIEICKSFKNCGYWADFIDPYSGAPYYGPHTNDTLFETDPRMRNFGLEIQDLGCCKVLSHPIWKENVFCGLIFTNAP 858
            RLE+T   C   +R  L ++FP   +  +   ++++ L+H  +  M              A   V ++ E+C    + GYWADF++P+SG P++ P     L+  D R R   + + +   C V+S        F G I++ AP
Sbjct:  135 RLEFTCCKCPLLIRVPLLEIFPVPVVAQQCINITMLVLSHEGDIEMG-------------AAKFVLAAREMCDRLLSYGYWADFMNPFSGRPFFLPREGANLYRLDSRFRGLNMRLSEQNRCTVISAEKNDSTRFSGTIYSTAP 265
[Close]
BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. Ensembl Zebrafish
Match: mmadhc (metabolism of cobalamin associated D [Source:ZFIN;Acc:ZDB-GENE-040704-50])

HSP 1 Score: 141.739 bits (356), Expect = 3.245e-39
Identity = 64/160 (40.00%), Postives = 97/160 (60.62%), Query Frame = 1 
Query:  415 FNSGRLEYTIHSCFKPLRRDLKDLFPDRDIMSEESPLSVVCLNHHTNANMSTWDSSVAEERIALANLVVNSSIEICKSFKNCGYWADFIDPYSGAPYYGPHTNDTLFETDPRMRNFGLEIQDLGCCKVLSHPIWKENVFCGLIFTNAPADHPMLNLLHND 894
            F+   +E  I SC + L+RD + +FP+    +  + + VV +   T  +M+ W   V +ER  L    +  + EIC + +N G+WADFIDP SG  Y+G +TN+TLFETD R R+ G +I+DLGCCKV+ H +W  + F G +FT+AP +  ++  L  D
Sbjct:  140 FDHSSVECAIQSCPELLKRDFESMFPE----APSTGMMVVTVTQRTQNDMTAWTEQVDQEREELLAKFIEGAKEICHALRNEGFWADFIDPSSGLAYFGSYTNNTLFETDDRYRHLGFQIEDLGCCKVIRHVMWGTHAFVGTLFTSAPPNSQIMKKLQGD 295
[Close]
BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. Ensembl Zebrafish
Match: zgc:92335 (zgc:92335 [Source:ZFIN;Acc:ZDB-GENE-040718-152])

HSP 1 Score: 73.1738 bits (178), Expect = 2.216e-14
Identity = 48/181 (26.52%), Postives = 90/181 (49.72%), Query Frame = 1 
Query:  370 INQFQSEE-------IKYDDFSFNSGRLEYTIHSCFKPLRRDLKDLFPDRDIMSEESPLSVVCLNHHTNANMSTWDSSVAEERIALANLVVNSSIEICKSFKNCGYWADFIDPYSGAPYYGPHTNDTLFETDPRMRNFGLEIQDLGCCKVLSHPIWKENVFCGLIFTNAPADHPMLNLLHN 891
            IN+FQ +E       +   +  F+   +E ++ SC + L+++L+  FP    +   SP++VV +           +  +  ++  L +  V+ + EIC +    GYWADFI+P SG  ++   T D++ + D +  + G  I+DL  C V+ H +  +  F   + TNAP++  ++  L  
Sbjct:  100 INEFQGKEASVAVQRVSKAELYFSQSDVECSMRSCPELLKKELELFFP----VLPTSPITVVTVMQK--------NQELTRDQEELLDNFVSGAKEICFTLWRGGYWADFINPLSGKAFFAVQTPDSILQQDVQ-HHAGFHIEDLASCTVIRHVL--KGTFVLTLITNAPSNSLIMEKLQG 265
[Close]
BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. Ensembl Zebrafish
Match: zgc:92335 (zgc:92335 [Source:ZFIN;Acc:ZDB-GENE-040718-152])

HSP 1 Score: 73.559 bits (179), Expect = 2.368e-14
Identity = 48/181 (26.52%), Postives = 90/181 (49.72%), Query Frame = 1 
Query:  370 INQFQSEE-------IKYDDFSFNSGRLEYTIHSCFKPLRRDLKDLFPDRDIMSEESPLSVVCLNHHTNANMSTWDSSVAEERIALANLVVNSSIEICKSFKNCGYWADFIDPYSGAPYYGPHTNDTLFETDPRMRNFGLEIQDLGCCKVLSHPIWKENVFCGLIFTNAPADHPMLNLLHN 891
            IN+FQ +E       +   +  F+   +E ++ SC + L+++L+  FP    +   SP++VV +           +  +  ++  L +  V+ + EIC +    GYWADFI+P SG  ++   T D++ + D +  + G  I+DL  C V+ H +  +  F   + TNAP++  ++  L  
Sbjct:  120 INEFQGKEASVAVQRVSKAELYFSQSDVECSMRSCPELLKKELELFFP----VLPTSPITVVTVMQK--------NQELTRDQEELLDNFVSGAKEICFTLWRGGYWADFINPLSGKAFFAVQTPDSILQQDVQ-HHAGFHIEDLASCTVIRHVL--KGTFVLTLITNAPSNSLIMEKLQG 285
[Close]
BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. Ensembl Xenopus
Match: ccdc172 (coiled-coil domain containing 172 [Source:Xenbase;Acc:XB-GENE-6460356])

HSP 1 Score: 146.362 bits (368), Expect = 8.484e-41
Identity = 71/179 (39.66%), Postives = 106/179 (59.22%), Query Frame = 1 
Query:  370 INQFQSEEIKYD-------DFSFNSGRLEYTIHSCFKPLRRDLKDLFPDRDIMSEESPLSVVCLNHHTNANMSTWDSSVAEERIALANLVVNSSIEICKSFKNCGYWADFIDPYSGAPYYGPHTNDTLFETDPRMRNFGLEIQDLGCCKVLSHPIWKENVFCGLIFTNAPADHPMLNLL 885
            + +FQ  E+  +       +  F + ++E  + SC   L++D   +FP+  I S    L V+ +   T+ +M+ W   V  ER  L    +N + EIC + +  GYWADFIDP SG  Y+GP+TN+TLFETD R R+ G +++DLGCCKV+ H +W  +V  G IFTNAP+D P++  L
Sbjct:  120 VTEFQGSEVSLEPQELNTMESYFENAKVECAMQSCPDLLKKDFASMFPE--IPSNN--LMVLTVTQRTHNDMTIWSQEVENEREMLIEKFMNGAKEICYALRTEGYWADFIDPLSGLAYFGPYTNNTLFETDERYRHLGFKVEDLGCCKVIRHNVWGTHVVVGSIFTNAPSDSPIMKKL 294
[Close]
BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. Ensembl Mouse
Match: Mmadhc (methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria [Source:MGI Symbol;Acc:MGI:1923786])

HSP 1 Score: 139.043 bits (349), Expect = 4.031e-38
Identity = 72/181 (39.78%), Postives = 104/181 (57.46%), Query Frame = 1 
Query:  370 INQFQ------SEEIKYDDFSFNSGRLEYTIHSCFKPLRRDLKDLFPDRDIMSEESPLSVVCLNHHTNANMSTWDSSVAEERIALANLVVNSSIEICKSFKNCGYWADFIDPYSGAPYYGPHTNDTLFETDPRMRNFGLEIQDLGCCKVLSHPIWKENVFCGLIFTNAPADHPMLNLLHND 894
            +N+FQ       +EI   +  F S ++E  I +C + LRRD + LFP+       S L ++ +   T  +M+ W   V  ER  L    ++ + EIC + +  GYWADFIDP SG  ++GP+TN+TLFETD R R+ G  + DLGCCKV+ H +W  +V  G IFTNA AD  ++  L  +
Sbjct:  120 VNEFQDSDAPVEQEINSAETYFESAKVECAIQTCPELLRRDFESLFPE----VANSKLMILTVTQKTENDMTVWSEEVEVEREVLLEKFISGAKEICYALRAEGYWADFIDPSSGVAFFGPYTNNTLFETDERYRHLGFSVDDLGCCKVIRHSLWGTHVVVGSIFTNATADSSIMRKLSGN 296
[Close]
BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. UniProt/SwissProt
Match: sp|Q6AYQ6|MMAD_RAT (Methylmalonic aciduria and homocystinuria type D homolog, mitochondrial OS=Rattus norvegicus OX=10116 GN=Mmadhc PE=2 SV=1)

HSP 1 Score: 152.91 bits (385), Expect = 1.497e-42
Identity = 76/181 (41.99%), Postives = 105/181 (58.01%), Query Frame = 1 
Query:  370 INQFQ------SEEIKYDDFSFNSGRLEYTIHSCFKPLRRDLKDLFPDRDIMSEESPLSVVCLNHHTNANMSTWDSSVAEERIALANLVVNSSIEICKSFKNCGYWADFIDPYSGAPYYGPHTNDTLFETDPRMRNFGLEIQDLGCCKVLSHPIWKENVFCGLIFTNAPADHPMLNLLHND 894
            +N+FQ       +EI   +  F S R+E  I +C + LRRD + LFP+       S L ++ +   T  +M+ W   V  ER AL    +N + EIC + +  GYWADFIDP SG  ++GP+TN+TLFETD R R+ G  + DLGCCKV+ H +W  +V  G IFTNA AD  ++  L  D
Sbjct:  120 VNEFQDSNAPVEQEISSAETYFESARVECAIQTCPELLRRDFESLFPE----VANSKLMILTVTQKTEHDMTVWSEEVEVEREALLEKFINGAKEICYALRAEGYWADFIDPSSGLAFFGPYTNNTLFETDERYRHLGFSVDDLGCCKVIRHGLWGTHVVVGSIFTNATADSHIMRKLSGD 296
[Close]
BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. UniProt/SwissProt
Match: sp|Q9H3L0|MMAD_HUMAN (Methylmalonic aciduria and homocystinuria type D protein, mitochondrial OS=Homo sapiens OX=9606 GN=MMADHC PE=1 SV=2)

HSP 1 Score: 144.436 bits (363), Expect = 2.129e-39
Identity = 74/181 (40.88%), Postives = 102/181 (56.35%), Query Frame = 1 
Query:  370 INQFQS------EEIKYDDFSFNSGRLEYTIHSCFKPLRRDLKDLFPDRDIMSEESPLSVVCLNHHTNANMSTWDSSVAEERIALANLVVNSSIEICKSFKNCGYWADFIDPYSGAPYYGPHTNDTLFETDPRMRNFGLEIQDLGCCKVLSHPIWKENVFCGLIFTNA-PADHPMLNLLHN 891
            +N+FQ       +EI   +  F S R+E  I +C + LR+D + LFP+         L ++ +   T  +M+ W   V  ER  L    +N + EIC + +  GYWADFIDP SG  ++GP+TN+TLFETD R R+ G  + DLGCCKV+ H +W  +V  G IFTNA P  H M  L  N
Sbjct:  120 VNEFQGNDAPVEQEINSAETYFESARVECAIQTCPELLRKDFESLFPE----VANGKLMILTVTQKTKNDMTVWSEEVEIEREVLLEKFINGAKEICYALRAEGYWADFIDPSSGLAFFGPYTNNTLFETDERYRHLGFSVDDLGCCKVIRHSLWGTHVVVGSIFTNATPDSHIMKKLSGN 296
[Close]
BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. UniProt/SwissProt
Match: sp|Q5ZKP2|MMAD_CHICK (Methylmalonic aciduria and homocystinuria type D homolog, mitochondrial OS=Gallus gallus OX=9031 GN=MMADHC PE=2 SV=1)

HSP 1 Score: 144.436 bits (363), Expect = 2.416e-39
Identity = 70/181 (38.67%), Postives = 108/181 (59.67%), Query Frame = 1 
Query:  370 INQFQS------EEIKYDDFSFNSGRLEYTIHSCFKPLRRDLKDLFPDRDIMSEESPLSVVCLNHHTNANMSTWDSSVAEERIALANLVVNSSIEICKSFKNCGYWADFIDPYSGAPYYGPHTNDTLFETDPRMRNFGLEIQDLGCCKVLSHPIWKENVFCGLIFTNAPADHPMLNLLHND 894
            IN+FQ       +++   +  F + ++E  + +C + LR+D + +FP+ +     + L+V+ +   T  +M+ W   V +ER  L    +N + EIC +  + GYWADFIDP SG  ++GP+TN+TLFETD R R+FG  + DLGCCKV+ H IW  +V  G IFTNA  D P++  L  +
Sbjct:  120 INEFQGSDVPQKQQVNNAETYFENAKVECAVQACPELLRKDFESMFPEVNA----NHLTVLTVTQKTKNDMTVWSQEVEDEREMLLENFINGAKEICYAICSEGYWADFIDPSSGLAFFGPYTNNTLFETDERYRHFGFSVDDLGCCKVIRHNIWGTHVVVGSIFTNAEPDSPIMRKLSGN 296
[Close]
BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. UniProt/SwissProt
Match: sp|Q99LS1|MMAD_MOUSE (Methylmalonic aciduria and homocystinuria type D homolog, mitochondrial OS=Mus musculus OX=10090 GN=Mmadhc PE=1 SV=1)

HSP 1 Score: 139.043 bits (349), Expect = 2.820e-37
Identity = 72/181 (39.78%), Postives = 104/181 (57.46%), Query Frame = 1 
Query:  370 INQFQ------SEEIKYDDFSFNSGRLEYTIHSCFKPLRRDLKDLFPDRDIMSEESPLSVVCLNHHTNANMSTWDSSVAEERIALANLVVNSSIEICKSFKNCGYWADFIDPYSGAPYYGPHTNDTLFETDPRMRNFGLEIQDLGCCKVLSHPIWKENVFCGLIFTNAPADHPMLNLLHND 894
            +N+FQ       +EI   +  F S ++E  I +C + LRRD + LFP+       S L ++ +   T  +M+ W   V  ER  L    ++ + EIC + +  GYWADFIDP SG  ++GP+TN+TLFETD R R+ G  + DLGCCKV+ H +W  +V  G IFTNA AD  ++  L  +
Sbjct:  120 VNEFQDSDAPVEQEINSAETYFESAKVECAIQTCPELLRRDFESLFPE----VANSKLMILTVTQKTENDMTVWSEEVEVEREVLLEKFISGAKEICYALRAEGYWADFIDPSSGVAFFGPYTNNTLFETDERYRHLGFSVDDLGCCKVIRHSLWGTHVVVGSIFTNATADSSIMRKLSGN 296
[Close]
BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. TrEMBL
Match: A0A2C9KY12 (Uncharacterized protein OS=Biomphalaria glabrata OX=6526 GN=106052291 PE=4 SV=1)

HSP 1 Score: 176.407 bits (446), Expect = 4.197e-49
Identity = 89/198 (44.95%), Postives = 125/198 (63.13%), Query Frame = 1 
Query:  325 LDELLNDR-YQQQIDVINQFQS--EEIKYD------DFSFNSGRLEYTIHSCFKPLRRDLKDLFPDRDIMSEESPLSVVCLNHHTNANMSTWDSSVAEERIALANLVVNSSIEICKSFKNCGYWADFIDPYSGAPYYGPHTNDTLFETDPRMRNFGLEIQDLGCCKVLSHPIWKENVFCGLIFTNAPADHPMLNLLHN 891
            +D LL +  +Q+  D+  QF +  +EI  D          +S RLEY  HSC   LR++ K+LFP R+IM  E  L+V+ ++  T  +M+ W S V +ER  L  + V S++ IC++F   G+WADFIDP SG P+   HTN TLFETD R R FG +I+DLGCCKV+SHP+W  + F G +FT AP +HP++  L+N
Sbjct:   99 VDSLLPEGPFQRHCDITEQFLTSIDEIDLDFIDKEISVPASSDRLEYRAHSCPTLLRKEFKELFPQRNIM--EGDLTVIIISMKTENDMTKWSSEVEQEREELLEMFVQSAVAICQAFDGSGHWADFIDPSSGKPFKSAHTNFTLFETDERYRKFGFDIRDLGCCKVISHPVWGTHSFIGSLFTTAPLNHPLVVNLNN 294
[Close]
BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. TrEMBL
Match: R7UJS2 (Uncharacterized protein OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_158712 PE=4 SV=1)

HSP 1 Score: 170.629 bits (431), Expect = 1.092e-47
Identity = 91/213 (42.72%), Postives = 122/213 (57.28%), Query Frame = 1 
Query:  247 FYKSFESQSTILNAMKFKPAPIVKSKLDELLNDRYQQQIDVINQFQSEEIKYDDFSFNSGRLEYTIHSCFKPLRRDLKDLFPDRDIMSEESPLSVVCLNHHTNANMSTWDSSVAEERIALANLVVNSSIEICKSFKNCGYWADFIDPYSGAPYYGPHTNDTLFETDPRMRNFGLEIQDLGCCKVLSHPIWKENVFCGLIFTNAPADHPMLNLL 885
            F K  + QST    +  +P P       E   D  QQ +D+    +  ++  + F      LE       + LR+D +DLFP++D  S    L+V+ L+ HT  NM+ W   V EER  +    V S+ +IC S +  GYWADFIDP SG PY GPHTN TLFETD R R+FG EI DLGCCKV+SH +W  + + G +FTNAP DHP+++ L
Sbjct:   31 FMKEEKVQSTAEPDVLTEPMPA------ERRGDLLQQYMDMA---EKSDVSPEMFEAAKLGLECVAQELPELLRKDFQDLFPEQDFRSRN--LTVITLSQHTENNMTMWSPEVEEEREVMLENFVCSASDICTSLQAAGYWADFIDPSSGKPYLGPHTNSTLFETDERFRHFGFEINDLGCCKVISHQLWGSHSYVGCLFTNAPLDHPVISQL 232
[Close]
BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. TrEMBL
Match: A0A5J4NS53 (Uncharacterized protein (Fragment) OS=Paragonimus westermani OX=34504 GN=DEA37_0008630 PE=4 SV=1)

HSP 1 Score: 172.17 bits (435), Expect = 2.636e-47
Identity = 80/152 (52.63%), Postives = 101/152 (66.45%), Query Frame = 1 
Query:  421 SGRLEYTIHSCFKPLRRDLKDLFPDRDIMSEESPLSVVCLNHHTNANMSTWDSSVAEERIALANLVVNSSIEICKSFKNCGYWADFIDPYSGAPYYGPHTNDTLFETDPRMRNFGLEIQDLGCCKVLSHPIWKENVFCGLIFTNAPADHPML 876
            S +LE TI++C   +++DL  +FP R    E +PL+ V L+H T   +S W    A ER ALA     S+I+IC S K  GYWADFI+PY+G PY G H   +L ETD +MR+FG EI D+ CCKVL HP WK NVF GLIFT+AP DHP+L
Sbjct:  163 SDQLECTIYTCPTLIKQDLVSIFPSRKF--EAAPLTAVVLSHRTTEGLSEWSELAASEREALAETFTKSAIDICASLKELGYWADFINPYTGTPYLGAHGEASLSETDDKMRHFGFEIDDVRCCKVLRHPRWKHNVFAGLIFTDAPKDHPVL 312
[Close]
BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. TrEMBL
Match: A0A4S2MMW6 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_000241 PE=4 SV=1)

HSP 1 Score: 171.014 bits (432), Expect = 2.886e-47
Identity = 87/201 (43.28%), Postives = 114/201 (56.72%), Query Frame = 1 
Query:  283 NAMKFKPAPIVKSKLDELLNDRYQQQIDVINQFQSEEIKYDDFSF---NSGRLEYTIHSCFKPLRRDLKDLFPDRDIMSEESPLSVVCLNHHTNANMSTWDSSVAEERIALANLVVNSSIEICKSFKNCGYWADFIDPYSGAPYYGPHTNDTLFETDPRMRNFGLEIQDLGCCKVLSHPIWKENVFCGLIFTNAPADHPML 876
            N +K +P P + + L             +I  + S E+     S     S  LE TIH+C   +++DL  +FP R    E S L+ + L+H T   +S W    A ER A+A     S+I+IC S K  GYWADFI+PY+G PY G H    L ETD +M++FG EI D+ CCKVL HP WK NVF GLIFT+AP DHP+L
Sbjct:   79 NDVKQQPKPFIPATLTLPPAREENYASALIETYNSTELNDGHVSLIPQKSENLECTIHTCPTLIKQDLAAIFPSRRF--ETSQLTAIVLSHRTTEGLSEWSELAANEREAIAETFTRSAIDICASLKELGYWADFINPYTGTPYLGAHGEAVLSETDEKMKHFGFEIDDVRCCKVLRHPRWKHNVFAGLIFTDAPKDHPVL 277
[Close]
BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. TrEMBL
Match: A0A0B7B8R0 (Uncharacterized protein OS=Arion vulgaris OX=1028688 GN=ORF170054 PE=4 SV=1)

HSP 1 Score: 169.859 bits (429), Expect = 1.094e-46
Identity = 87/184 (47.28%), Postives = 120/184 (65.22%), Query Frame = 1 
Query:  352 QQQIDVINQFQS--EEIKYD--DFSFNS----GRLEYTIHSCFKPLRRDLKDLFPDRDIMSEESPLSVVCLNHHTNANMSTWDSSVAEERIALANLVVNSSIEICKSFKNCGYWADFIDPYSGAPYYGPHTNDTLFETDPRMRNFGLEIQDLGCCKVLSHPIWKENVFCGLIFTNAPADHPMLN 879
            QQQ D+  QF    +EI  D  D + +S     ++EY  HSC   LR++ ++LFPDR+IM  E  L+VV ++  T  +M+ W S V  ER  +  + +  S+EIC++F++ GYWADFIDP SG P+ GPHTN TLFETD R R  G EIQDLGCCKV+SHP+W    + G +FT+A  D+P++ 
Sbjct:  109 QQQADIAEQFLDSLDEIDVDFMDTTISSPTASDKMEYRAHSCPTLLRKEFRELFPDRNIM--EGDLTVVTISLKTVNDMTLWSSEVEREREEMLEIFIQGSLEICQAFEDSGYWADFIDPGSGKPFKGPHTNFTLFETDERYRKLGFEIQDLGCCKVISHPVWGTRSYIGCLFTSASIDNPLVT 290
[Close]
BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. Ensembl Cavefish
Match: mmadhc (metabolism of cobalamin associated D [Source:NCBI gene;Acc:103036767])

HSP 1 Score: 145.591 bits (366), Expect = 7.304e-41
Identity = 72/201 (35.82%), Postives = 117/201 (58.21%), Query Frame = 1 
Query:  298 KPAPIVKSKLDELLNDRYQQQID-VINQFQSE-EIKYDDFSFNSGRLEYTIHSCFKPLRRDLKDLFPDRDIMSEESPLSVVCLNHHTNANMSTWDSSVAEERIALANLVVNSSIEICKSFKNCGYWADFIDPYSGAPYYGPHTNDTLFETDPRMRNFGLEIQDLGCCKVLSHPIWKENVFCGLIFTNAPADHPMLNLLHND 894
            K AP  K+  D L      ++ + ++ QF ++  +   +  F+  ++E  I SC + L++D + +FP+    +  + + VV +   T  +M+ W   V +ER  L    ++ + EIC + +  G+WADFIDP SG  ++G +TN+TLFETD R RN G +I+DLGCCKV+ H +W  +VF G +FTNAP +  ++  L  D
Sbjct:   87 KSAPTHKTVPDVLTAPSSSERHEFILAQFVTDFHVSISNHYFDHSKVECAIQSCPELLKKDFESMFPE----APSNGMMVVTVTQKTKNDMTAWSEEVDQEREELLEKFISGAKEICLALRTEGFWADFIDPSSGLAFFGSYTNNTLFETDERYRNLGFQIEDLGCCKVIRHTLWGTHVFVGTVFTNAPTNSLIMKKLQGD 283
[Close]
BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. Ensembl Cavefish
Match: mmadhc (metabolism of cobalamin associated D [Source:NCBI gene;Acc:103036767])

HSP 1 Score: 145.206 bits (365), Expect = 1.132e-40
Identity = 66/170 (38.82%), Postives = 102/170 (60.00%), Query Frame = 1 
Query:  385 SEEIKYDDFSFNSGRLEYTIHSCFKPLRRDLKDLFPDRDIMSEESPLSVVCLNHHTNANMSTWDSSVAEERIALANLVVNSSIEICKSFKNCGYWADFIDPYSGAPYYGPHTNDTLFETDPRMRNFGLEIQDLGCCKVLSHPIWKENVFCGLIFTNAPADHPMLNLLHND 894
            S  +   D  F+  ++E  I SC + L++D + +FP+    +  + + VV +   T  +M+ W   V +ER  L    ++ + EIC + +  G+WADFIDP SG  ++G +TN+TLFETD R RN G +I+DLGCCKV+ H +W  +VF G +FTNAP +  ++  L  D
Sbjct:  128 SSSVSSPDHYFDHSKVECAIQSCPELLKKDFESMFPE----APSNGMMVVTVTQKTKNDMTAWSEEVDQEREELLEKFISGAKEICLALRTEGFWADFIDPSSGLAFFGSYTNNTLFETDERYRNLGFQIEDLGCCKVIRHTLWGTHVFVGTVFTNAPTNSLIMKKLQGD 293
[Close]
BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. Ensembl Cavefish
Match: mmadhc (metabolism of cobalamin associated D [Source:NCBI gene;Acc:103036767])

HSP 1 Score: 144.05 bits (362), Expect = 7.050e-40
Identity = 66/170 (38.82%), Postives = 102/170 (60.00%), Query Frame = 1 
Query:  385 SEEIKYDDFSFNSGRLEYTIHSCFKPLRRDLKDLFPDRDIMSEESPLSVVCLNHHTNANMSTWDSSVAEERIALANLVVNSSIEICKSFKNCGYWADFIDPYSGAPYYGPHTNDTLFETDPRMRNFGLEIQDLGCCKVLSHPIWKENVFCGLIFTNAPADHPMLNLLHND 894
            S  +   D  F+  ++E  I SC + L++D + +FP+    +  + + VV +   T  +M+ W   V +ER  L    ++ + EIC + +  G+WADFIDP SG  ++G +TN+TLFETD R RN G +I+DLGCCKV+ H +W  +VF G +FTNAP +  ++  L  D
Sbjct:  160 SSSVSSPDHYFDHSKVECAIQSCPELLKKDFESMFPE----APSNGMMVVTVTQKTKNDMTAWSEEVDQEREELLEKFISGAKEICLALRTEGFWADFIDPSSGLAFFGSYTNNTLFETDERYRNLGFQIEDLGCCKVIRHTLWGTHVFVGTVFTNAPTNSLIMKKLQGD 325
[Close]
BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. Ensembl Cavefish
Match: zgc:92335 (methylmalonic aciduria and homocystinuria type D protein, mitochondrial-like [Source:NCBI gene;Acc:103022258])

HSP 1 Score: 86.2705 bits (212), Expect = 8.097e-19
Identity = 55/185 (29.73%), Postives = 91/185 (49.19%), Query Frame = 1 
Query:  370 INQFQSEEI--------KYDDFSFNSGRLEYTIHSCFKPLRRDLKDLFPDRDIMSEESPLSVVCLNHHTNANMSTWDSSVAEERIALANLVVNSSIEICKSFKNCGYWADFIDPYSGAPYYGPHTNDTLFETDPRMRNF-GLEIQDLGCCKVLSHPIWKENVFCGLIFTNAPADHPMLNLLHNDS 897
            IN++QS+E+        K + + F+   +E ++HSC + L+++L+  FP        S ++VV +           D      R  L N  V+ + EIC      GYWADFIDP SG  ++G   +D++ + + + R   G  I+DL  C V+ H +     F G + TNAP++  ++  L   S
Sbjct:  112 INEYQSKEVSLWLQRVSKAEQY-FHHSDVECSMHSCPQLLKQELESFFP----TLPASAITVVTVVQKPATEAEELD------REQLLNKFVSGAKEICFMLWREGYWADFIDPLSGNAFFGAKLSDSILQPEQQQRGHSGFHIEDLASCMVIRHILKDTPTFVGTLITNAPSNSRIMTRLKGQS 285
[Close]
BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002104.1 (pep scaffold:Pmarinus_7.0:GL485642:9237:10716:-1 gene:ENSPMAG00000001911.1 transcript:ENSPMAT00000002104.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 106.686 bits (265), Expect = 6.815e-29
Identity = 42/86 (48.84%), Postives = 57/86 (66.28%), Query Frame = 1 
Query:  619 VNSSIEICKSFKNCGYWADFIDPYSGAPYYGPHTNDTLFETDPRMRNFGLEIQDLGCCKVLSHPIWKENVFCGLIFTNAPADHPML 876
            V  + EIC + +  GYWADF+DP SG P++GP+TN  LFETD R R  G +++DLGCCKV+ H  W  +V  G + T+AP    +L
Sbjct:    6 VEGAKEICFALRAEGYWADFVDPSSGMPFFGPYTNSPLFETDGRYRQLGFQVEDLGCCKVIRHRTWGSHVLVGSLLTDAPTSSSLL 91
[Close]
BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. Ensembl Nematostella
Match: EDO44830 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RUY2])

HSP 1 Score: 145.976 bits (367), Expect = 5.827e-42
Identity = 70/151 (46.36%), Postives = 96/151 (63.58%), Query Frame = 1 
Query:  439 TIHSCFKPLRRDLKDLFPDRDIMSEESPLSVVCLNHHTNANMSTWDSSVAEERIALANLVVNSSIEICKSFKNCGYWADFIDPYSGAPYYGPHTNDTLFETDPRMRNFGLEIQDLGCCKVLSHPIWKENVFCGLIFTNAPADHPML-NLLH 888
            ++ +C   L R   +LFPD+ +  +   L+V+ ++ H+  +MS W+  V EER  L +  V S+ EIC +    GYWADFIDP SG  Y+GPHTN TLFETD R  + G  + DLGCCKV+SH +W    F G +FTNAPAD  +L ++LH
Sbjct:   93 SVQTCPSFLHRGFMELFPDKSL--QPGDLTVISISQHSKNDMSLWNVDVEEEREQLMSNFVESAKEICNNLMAAGYWADFIDPSSGTSYFGPHTNTTLFETDERFNHLGFNVMDLGCCKVISHHLWGTYAFIGSLFTNAPADCDILSDVLH 241
[Close]
BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. Ensembl Medaka
Match: zgc:92335 (metabolism of cobalamin associated D [Source:NCBI gene;Acc:101167432])

HSP 1 Score: 78.1814 bits (191), Expect = 4.874e-16
Identity = 55/216 (25.46%), Postives = 100/216 (46.30%), Query Frame = 1 
Query:  280 LNAMKFKPAPIVKSKLDELL----NDRYQQQI--DVINQFQ------SEEIKYDDFSFNSGRLEYTIHSCFKPLRRDLKDLFPDRDIMSEESPLSVVCLNHHTNANMSTWDSSVAEERIALANLVVNSSIEICKSFKNCGYWADFIDPYSGAPYYGPHTNDTLFETDPRMRNFGLEIQDLGCCKVLSHPIWKENVFCGLIFTNAPADHPMLNLLHN 891
            L  M  +P   V   + ++L    +   QQ I    +N+FQ      S  +   +  FN    + +I+SC + LR++L+ LFP     S    ++VV +    +   +       E  +   +  V+ + E+C +    GYWADFI+P +GA ++   ++ +    D ++R+ G  I+  G C V+ H +    +F G +FT+AP +   +  L  
Sbjct:   84 LEGMGNRPKTPVHKTVPDILTAPSSAERQQFILAQFVNEFQGKLGPISGRVHKAEQYFNQADADCSINSCPELLRKELEQLFPSAPAAS----ITVVTVAQKDSRRFAETPDLDQEHVL---HKFVSGAKEMCFALWTAGYWADFINPTTGAAFFASPSSTSTLRPDEQLRHLGFRIEVSGSCTVIRHVLNGSPLFVGTVFTSAPTNSAAIARLQG 292
[Close]
BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. Planmine SMEST
Match: SMESG000030431.1 (SMESG000030431.1)

HSP 1 Score: 540.421 bits (1391), Expect = 0.000e+0
Identity = 257/261 (98.47%), Postives = 258/261 (98.85%), Query Frame = 1 
Query:  115 MRALIQYKNSNLSWCALLKHFRRYASLQNTTTKTLVVNERICDNFYKSFESQSTILNAMKFKPAPIVKSKLDELLNDRYQQQIDVINQFQSEEIKYDDFSFNSGRLEYTIHSCFKPLRRDLKDLFPDRDIMSEESPLSVVCLNHHTNANMSTWDSSVAEERIALANLVVNSSIEICKSFKNCGYWADFIDPYSGAPYYGPHTNDTLFETDPRMRNFGLEIQDLGCCKVLSHPIWKENVFCGLIFTNAPADHPMLNLLHNDS 897
            MRALIQYKNSNLSWCALLKHFRRYASLQNTTTKTLVVNERICDNFYKSFESQSTILNAMKFKPAPIVKSKLDELLNDRYQQQIDVINQFQSEEIKYD  SFN GRLEYTIHSCFKPLRRDLKDLFPDRDIMSEESPLSV+CLNHHTNANMSTWDSSVAEERIALANLVVNSSIEICKSFKNCGYWADFIDPYSGAPYYGPHTNDTLFETDPRMRNFGLEIQDLGCCKVLSHPIWKENVFCGLIFTNAPADHPMLNLLHNDS
Sbjct:    1 MRALIQYKNSNLSWCALLKHFRRYASLQNTTTKTLVVNERICDNFYKSFESQSTILNAMKFKPAPIVKSKLDELLNDRYQQQIDVINQFQSEEIKYDGVSFNLGRLEYTIHSCFKPLRRDLKDLFPDRDIMSEESPLSVICLNHHTNANMSTWDSSVAEERIALANLVVNSSIEICKSFKNCGYWADFIDPYSGAPYYGPHTNDTLFETDPRMRNFGLEIQDLGCCKVLSHPIWKENVFCGLIFTNAPADHPMLNLLHNDS 261
The following BLAST results are available for this feature:
BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 3
Match NameE-valueIdentityDescription
MMADHC4.433e-4040.88metabolism of cobalamin associated D [Source:HGNC ... [more]
MMADHC4.433e-4040.88metabolism of cobalamin associated D [Source:HGNC ... [more]
MMADHC2.828e-3335.35metabolism of cobalamin associated D [Source:HGNC ... [more]
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BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Y76A2B.56.360e-3537.43pep chromosome:WBcel235:III:13546889:13549020:-1 g... [more]
Y76A2B.56.360e-3537.43pep chromosome:WBcel235:III:13546889:13549005:-1 g... [more]
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BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2
Match NameE-valueIdentityDescription
CG121182.023e-1227.08gene:FBgn0030101 transcript:FBtr0071339[more]
CG121182.023e-1227.08gene:FBgn0030101 transcript:FBtr0071340[more]
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BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 3
Match NameE-valueIdentityDescription
mmadhc3.245e-3940.00metabolism of cobalamin associated D [Source:ZFIN;... [more]
zgc:923352.216e-1426.52zgc:92335 [Source:ZFIN;Acc:ZDB-GENE-040718-152][more]
zgc:923352.368e-1426.52zgc:92335 [Source:ZFIN;Acc:ZDB-GENE-040718-152][more]
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BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ccdc1728.484e-4139.66coiled-coil domain containing 172 [Source:Xenbase;... [more]
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BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 1
Match NameE-valueIdentityDescription
Mmadhc4.031e-3839.78methylmalonic aciduria (cobalamin deficiency) cblD... [more]
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BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 4
Match NameE-valueIdentityDescription
sp|Q6AYQ6|MMAD_RAT1.497e-4241.99Methylmalonic aciduria and homocystinuria type D h... [more]
sp|Q9H3L0|MMAD_HUMAN2.129e-3940.88Methylmalonic aciduria and homocystinuria type D p... [more]
sp|Q5ZKP2|MMAD_CHICK2.416e-3938.67Methylmalonic aciduria and homocystinuria type D h... [more]
sp|Q99LS1|MMAD_MOUSE2.820e-3739.78Methylmalonic aciduria and homocystinuria type D h... [more]
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BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A2C9KY124.197e-4944.95Uncharacterized protein OS=Biomphalaria glabrata O... [more]
R7UJS21.092e-4742.72Uncharacterized protein OS=Capitella teleta OX=283... [more]
A0A5J4NS532.636e-4752.63Uncharacterized protein (Fragment) OS=Paragonimus ... [more]
A0A4S2MMW62.886e-4743.28Uncharacterized protein OS=Opisthorchis felineus O... [more]
A0A0B7B8R01.094e-4647.28Uncharacterized protein OS=Arion vulgaris OX=10286... [more]
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BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 4
Match NameE-valueIdentityDescription
mmadhc7.304e-4135.82metabolism of cobalamin associated D [Source:NCBI ... [more]
mmadhc1.132e-4038.82metabolism of cobalamin associated D [Source:NCBI ... [more]
mmadhc7.050e-4038.82metabolism of cobalamin associated D [Source:NCBI ... [more]
zgc:923358.097e-1929.73methylmalonic aciduria and homocystinuria type D p... [more]
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BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ENSPMAT00000002104.16.815e-2948.84pep scaffold:Pmarinus_7.0:GL485642:9237:10716:-1 g... [more]
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BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO448305.827e-4246.36Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
zgc:923354.874e-1625.46metabolism of cobalamin associated D [Source:NCBI ... [more]
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BLAST of Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000030431.10.000e+098.47SMESG000030431.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30030643 ID=SMED30030643|Name=Methylmalonic aciduria and homocystinuria type D-like protein, mitochondrial|organism=Schmidtea mediterranea sexual|type=transcript|length=1051bp
CAAACATAAGTTTAAATAGACTAAATTCGTCTTTTCACAATTGTTATTTC
AAAATTAATTTTTCGCACGTAATTACTATAATTGATTTCATTAAAGTTAT
CTGTATTTTTCACAATGAGAGCATTAATTCAGTATAAGAATTCGAATCTT
AGTTGGTGTGCTCTTCTCAAACATTTTAGAAGATATGCATCACTTCAAAA
TACTACTACCAAAACTCTAGTTGTAAATGAAAGAATTTGTGATAATTTCT
ATAAATCTTTTGAATCACAATCGACAATTCTAAATGCGATGAAATTCAAA
CCAGCTCCTATTGTCAAAAGTAAATTAGATGAATTGCTCAATGATAGATA
CCAACAACAAATTGATGTTATAAATCAATTTCAATCGGAAGAAATTAAAT
ATGACGACTTCAGTTTTAATTCGGGACGGCTTGAATATACAATTCATAGT
TGTTTTAAGCCTTTAAGGCGAGATCTGAAAGATTTATTTCCCGATCGTGA
CATAATGTCAGAGGAATCTCCTTTGTCCGTGGTTTGTTTGAATCATCATA
CTAACGCAAATATGTCCACTTGGGATTCTTCGGTTGCCGAAGAAAGGATC
GCACTAGCAAATTTGGTCGTAAATTCATCAATTGAAATTTGTAAATCATT
TAAGAACTGTGGGTATTGGGCCGATTTTATCGACCCATACAGTGGAGCGC
CGTATTACGGACCGCATACGAATGATACTCTTTTCGAAACCGATCCACGA
ATGAGAAATTTCGGTCTGGAAATTCAAGATCTAGGTTGCTGCAAGGTTCT
TTCTCATCCGATTTGGAAGGAAAACGTTTTTTGCGGACTGATTTTCACAA
ATGCTCCTGCTGATCATCCAATGCTGAATCTTCTTCACAATGACTCTTGA
TTGAATGCTCATTTTCATTTTGTTCACCTCATATATCCCTCTCTCTGTTA
TCTGCAATGCTGCAGTGCTTCTGTCATCTGTGGCCGTTGATAGTCATGAT
TTTCACAACATTAGTCATTAGAAATATATCTCTGCTTTTGTTTAAAAAAA
A
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protein sequence of SMED30030643-orf-1

>SMED30030643-orf-1 ID=SMED30030643-orf-1|Name=SMED30030643-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=262bp
MRALIQYKNSNLSWCALLKHFRRYASLQNTTTKTLVVNERICDNFYKSFE
SQSTILNAMKFKPAPIVKSKLDELLNDRYQQQIDVINQFQSEEIKYDDFS
FNSGRLEYTIHSCFKPLRRDLKDLFPDRDIMSEESPLSVVCLNHHTNANM
STWDSSVAEERIALANLVVNSSIEICKSFKNCGYWADFIDPYSGAPYYGP
HTNDTLFETDPRMRNFGLEIQDLGCCKVLSHPIWKENVFCGLIFTNAPAD
HPMLNLLHNDS*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000020protonephridia
PLANA:0000101muscle cell
PLANA:0000418head
Vocabulary: INTERPRO
TermDefinition
IPR019362MMADHC
Vocabulary: biological process
TermDefinition
GO:0009235cobalamin metabolic process
GO:0009108coenzyme biosynthetic process
Vocabulary: cellular component
TermDefinition
GO:0005737cytoplasm
GO:0005739mitochondrion
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR019362Methylmalonic aciduria and homocystinuria type D proteinPFAMPF10229MMADHCcoord: 83..255
e-value: 3.8E-50
score: 171.2
IPR019362Methylmalonic aciduria and homocystinuria type D proteinPANTHERPTHR13192MY011 PROTEINcoord: 87..255
NoneNo IPR availablePANTHERPTHR13192:SF3METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE D PROTEIN, MITOCHONDRIALcoord: 87..255