Cytochrome P450 2C3

Query:  108 PPGPIGWPVFGSTPERLYW-YLTGREYSQSKC---------------YSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXX-XXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNIQVIGQDGNVNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFD--NPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEI-KANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAP 1505
            PPGP  WP+ G+    L   +L  R +  S+                 + +   YG+++S  + H   +V + +  + E+LV Q   FS+RP+ +P++  V+K+ G++    G  W+  RK +   +   G+  L++E K+++E + +  E+ K    P     + S  V NIIC L   + F+Y + +F  ++      G +  +N    + +I   W++   F   +     L ++EK + S L    +      D  NP   ++ YL L  ++E    S+  + +  +     D++ AG DTTT+ L WC L + L PD Q ++  EI +   +N A +        + +A + E  R   V+  A+ H   +    +G+ +    L++ +  ++ +DP IW+ PE+F P RF+D+   L K  +  I FGIGKR CMGE LA+ EL ++ +S++Q+F   L +++ +    +++G  GL  AP
Sbjct:   60 PPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGIDPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPR-VPLISIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGEDPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKML-GFMSRGLEICLNSQVLLVNICP-WLYYLPFGPFK----ELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYL-LHMEEERKNNSNSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQLIK-KETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALPEDSKKP---LLTGRFGLTLAP 534          

Query:   36 MFIGILCFLIALLFLYHYYQRQKD-PPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDD---QKFINVIKNIQVIGQDGNVNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEI-KANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAPLEHEIIYIP 1532
            + +G + FL+A  FL    +R K+ PPGP   P  G+      ++L   E S  +    +K KYG L+S +L  I  ++     LI E+L+     F NRP   P+ +++ KK G+I   G+ WK  R+ TL  +   G+   ++E+++ +E++ L + I +   +P       +  V NIIC +     FEY D   Q+ + ++  +  +       L          WI +      +    N ++L+ +V   +D   + +NP        ++ YL    +   N  SS  + +  +I +  D++ AG +TT+  L W  L + L P+ Q +++ EI +        +    +S  +  A + E  R   +I   V   V       G+HL    +++ +   + +DP  W  P+ F+P  F++  +  +K  +  + F IGKR+C+GE LAR EL I   S++Q F  +   N      L +    G+  +P+ H +  +P
Sbjct:   21 LLLGTVAFLLAADFLKR--RRPKNYPPGPWRLPFLGN------FFLVDFEQSHLEVQLFVK-KYGNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVT-PMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFP-----WIMKFLPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPA--ETRDFIDAYLKEMSKHTGNPTSS--FHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLENGQ--FKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNE----KLSLKFRMGITISPVSHRLCAVP 500          

Query:   48 ILCFLIALLFLY--HYYQRQKDPPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIK----NIQVIGQDGNVNLLFFMRSIINFWIFRETF--------KSVRIYMDNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEIK-ANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMMDFKT-MSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAPLEHEIIYIPI 1535
            +LC    LLF       +R+K PPGP   P+ G+        L        K ++   + YG +++        +VF  YE + E+L+  G +FS R  + PI   ++K  GII   GK WK  R+ +L  +   GM   +IED+V +E+  L++E+ K+   P     +      N+IC ++  + F+Y DQ F+ ++K    N +++          +++   NF +  + F        K+V +    + E  K  ++ LD          +NP   ++ +L+  +Q++ N +S   ++   ++    D++ AG +TT+  L +  L+L   P+   +++ EI      + +          +  A + E  RY  ++   V HAV     F+ + L+P+   +M   T +  D   + +P  FDP  F+D+  + +K + + + F  GKR C GE LAR EL + L +I+QNF +K + + L+N+N   + T+G++  P  ++I +IP+
Sbjct:    8 VLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGN-------MLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGR-GNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSP-------WIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDV---------NNPRDFIDCFLIKMEQEKDNQKSE--FNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNY-LIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGN-FKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLK-SVDDLKNLN-TTAVTKGIVSLPPSYQICFIPV 490          

Query:  198 CYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVS----XXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNIQVIGQDGNVNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFD---NPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEI--------KANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAPLEHEIIYIP 1532
            C+ +++ ++G ++S +L     +V      + E+LV  G   ++RP  +PI   +      +G  +   G  W+  R+ ++  +  LG+   ++E  V +E+  L       + +P + + L  K V N+I  L   R FEYDD +F+ ++     + Q+G      F+R ++N          +      +   +K   +QLD    +    +D    P  + E +L   ++ + N ESS  ++   +     D++ AG+ TT+  L W  L++ L PD Q R++ EI        +    + A    TT   H       E  R+  ++   V H   + I+ +GF +     L+ +  ++ KD  +W+ P  F P  F+D   H  KP   L  F  G+R+C+GE LAR EL +   S++Q+F   +        +    G    +  P  +E+  +P
Sbjct:   57 CFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPP-VPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLD----LAQEGLKEESGFLREVLNAV---PVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESS--FNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIH-------EVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFL-PFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSH---HGVFAFLVTPSPYELCAVP 496          

Query:  198 CYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVS----XXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNIQVIGQDGNVNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFD---NPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEI--------KANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAPLEHEIIYIP 1532
            C+ +++ ++G ++S +L     +V      + E+LV  G   ++RP  +PI   +      +G  +   G  W+  R+ ++  +  LG+   ++E  V +E+  L       + +P + + L  K V N+I  L   R FEYDD +F+ ++     + Q+G      F+R ++N          +      +   +K   +QLD    +    +D    P  + E +L   ++ + N ESS  ++   +     D++ AG+ TT+  L W  L++ L PD Q R++ EI        +    + A    TT   H       E  R+  ++   V H   + I+ +GF +     L+ +  ++ KD  +W+ P  F P  F+D   H  KP   L  F  G+R+C+GE LAR EL +   S++Q+F   +        +    G    + +P  +E+  +P
Sbjct:   57 CFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPP-VPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLD----LAQEGLKEESGFLREVLNAV---PVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESS--FNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIH-------EVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFL-PFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSH---HGVFAFLVSPSPYELCAVP 496          

Query:   36 MFIGILCFLIALLFLYHYYQRQKDPPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEI----FKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNIQVIGQDGNVNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKW-VESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEI-KANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQ-RAVHAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAPLEHEIIYIPI 1535
            + I +L    A+   Y + + Q+ P GP   P+ G+  + +Y+ +  +  S    Y E ++ YG +++  +  +  +  + Y++ +ES + +   FS R       +Y+ +  GII   G +W+ HR+  L  +   G+    +E+K+++E    + +      K+    + +   +   V +II QL+++  FE  DQ+F  +  ++ +  ++  +  +FF  +I++  + +   K +    D + E+ K  +  +++A     +   D     ++ Y +L+ Q++ N  +   ++   +I + FD++ AG +TT+  L W    L   P+   ++R E+ K    N  +  N      +  A  +E  R   ++       +E+  +  G  L    ++      +  D +++K+P EF P RF++         K LI FGIGKRSC GE+LAR EL +IL ++I + EI+   +  +   ++ S   GL+  P  ++I + P+
Sbjct:    2 LIILLLVTFFAVATAYQWRKCQRLPKGPTPLPLIGNFHQFIYYGI--KLGSAVAVYHEFEKTYGKVFTIWMGPLPSVYISDYDVAHESHIKRANIFSTRFAH-GTTNYIREGRGIIAANGDFWQDHRRFALTTLRNFGLGRNLMEEKIMEEYNYRISDYKRTHLKNGAIEIHAGTFFDLLVGSIINQLLISERFEQGDQEFEKIKTSLALSLENFGIIDIFFPTAILDSPLMKWRQKKIFEPFDFIYEVSKRNLTKRMEAVKSGDHVIEDGGRDFVDAY-ILKIQKDENSGAPSTFNLETMIIDVFDLWQAGQETTSTTLTWAFCCLLNHPNVVKKLRAELMKLTGGNRHVGLNDRADTPYLNAVCNEVQRIASILNINLFRKIEQDTEIAGQPLASGCVVTTQMSMLHTDVEVYKNPTEFRPERFLENN----TLEKKLIPFGIGKRSCPGESLARAELYLILSNVILDVEIEAVGSIPK---ILTSNPFGLLRRPPSYDIRFKPL 497          

Query:   42 IGILCFLIALLFLYHYY--QRQKDPPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSN-----------RPKDLPIMDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSK---PVMNIICQLMLNRSFE----YDDQKFINVIKN-IQVIGQDGNVNLLFFMRSIINFWIFRETFKSVRIYMDNLEE----LEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEIKANKSNSA--MNFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENI 1463
            I I   L  L FL H Y  +R+  PPGP   P+FG+      + L+G E      + + K++YG +++  +  +  +V   Y+ I E+++  G  +++           R  +  IMD    +          WK HRK  +  + +LG+    +E K++ E+E+L++++ K+A    +   L S+    V ++I Q +    F+    ++  +   ++ N ++ +G+   V L F    I +F         V++ +  +EE    L +++  Q+D    + N E ++    +E YL  + Q+E   +  D Y   Q+   CFDI+ AG DT T+ + +        P+ Q  I  EI    ++ +  +      +  +F AF +E  R   ++   + HA+ + +  KG+HL     ++     +  D  I+K  + FDP RF+DE   L K  + L  F +GKR C+GE LAR E+ ++  ++   FE     + L ++
Sbjct:    2 ILIFFALCTLFFLIHQYLWRRRGLPPGPTPIPIFGNL-----FQLSGSEAPGISIFQKWKDQYGPIFTFYMGPVPFVVLTDYQDIKETVIKDGDTYADKYLSPEFNKYFRGGEYGIMDISGDR----------WKEHRKFAVLQLRELGVGKPLMESKILIEAEELIKKL-KTAEILNEDFLLQSELDVAVGSVINQFLFGYRFDRSKLFEFTRIKTLVNNFMEEVGKPLGV-LAFTCHGIPSFL--------VKLMVSGIEEQKRELFRFLRKQIDGAKSQINYEEEHNEDFVEAYLRKKFQREQKNDF-DSYCDSQLENVCFDIWAAGFDTLTNTVGFLIAYAINYPEMQMLIHQEIDNYLAHHSRLLTLADKNALVYFNAFANEAQRVSNILPMNLPHALTRDVKLKGYHLKKGTGVIHQIANVMTDETIFKDSQRFDPNRFIDENGKL-KKIEELCPFSMGKRQCIGEGLARMEIFLLAANLFNYFEFLPASDGLPSL 476          

Query:   48 ILCFLIALLFLYHYYQRQKD-PPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMD-YVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFIN---VIKNIQVIGQDGNVNLL------FFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEIKANKSNS-AMNFNTTKSFHFFKAFLDECFR---YFPV--IQRAVHAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIIS 1478
            ++  +I +LFL  +  + +  PPGP  WP  G+T           E       +E K+KYG +++  L     IV   Y+++  ++V  G  FS RP D  IMD  V    G+ F+   +WKA R+ T  I   LG+     +D +   +  L+++I    +KP++   L    V N+I + +   + E+++ + ++    I ++          LL       ++   ++  I R T  +  I + NLE+     ++ ++   E        PS  ++ +L   K + +     D +++ Q+I   +D+Y AG++T   +L +  L L   P+ Q RI  E+  N      +  +  K   +  AFL E +R     PV  ++  +  VE   D +G+ L     ++  F+++  D   +  PE F+P RF++ +R  Y  +  +  F +GKRSC+GENLAR E+ +   +++QNFE          I++I S
Sbjct:    7 VILVIIVMLFLCRFANKLRGLPPGPTPWPFIGNT-------FQVPEDRIDLIINEFKKKYGGIFTLWL-PFPTIVICDYDMLKRNIVKNGESFSGRP-DTFIMDMLVQGNYGLFFMENNWWKAQRRFTTHIFRSLGVGQAGTQDTIASLASGLVEKIDGQKDKPIELRPLLVHVVGNVIHKHLFGFTREWNETEILDFHVAINDVLEHFTSPKTQLLDAWPWLAYLDKPLSLGIPRTTRANDAI-IQNLEQALAKHKTGINYDEE--------PSSYMDAFLKEMKIRAAENALEDGFTEKQLIVAIYDLYSAGMETIIIVLRFAFLYLVNNPETQKRIHEELDRNVGRERQVVMDDQKHLPYTCAFLQEVYRLGYVLPVNFLRCTLTDVE---DCEGYRLNAGTRVIAQFQSVHVDKKHFPDPEHFNPDRFLN-SRGEYIRDDRVNPFSMGKRSCLGENLARMEVFLYFCTLMQNFEWHTDGPYAPPIDVITS 478          

Query:   36 MFIGILCFLIALLFLYHYYQRQKD-PPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNIQVIGQDGNVNLLFFMRSIINFWI-----------FRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFDNPSCI--LEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEIKANKSNSAMNFNTTKS-FHFFKAFLDECFRYFPVIQ-RAVHAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEI 1433
            M + ++   I L F YH++ ++++ PPGP   P  G+    L     G E      +S  K++YG +++  + +   ++ ASYE + E+ V  G  + ++       + + +  G++   G  WK HR+ TL  +  LG+    +++K++ E E+L +E+     + +   KL  + V N+I   + N+ F+ D +     +K++     DG  N+    R +I + +             E  ++ R      EEL+ +  SQ+D    + +  FDN   +  +E YL  QK++E +G+     +K Q+    FD++ AG+ TTT  + W        P+ Q +IR E+     N  +     K+   + +AF+ E  R   +I    +H   +     GF +     ++    T+  D  ++  P +F P RF++  +  +K    +I F IGKR C+GE LAR EL +   +I   +++
Sbjct:    1 MLLLLIFSSIFLYFFYHFHWKRRNLPPGPRPLPFLGNLLS-LKTLKPGYE-----AFSNWKKEYGPIFTFWMANKPFVIIASYEKMKETFVKDGDTYVDKQLTHTEKERLGENYGVLDTNGHMWKEHRRFTLTQLRDLGLGKDLMQEKILMEVEELFKELDAHGGEEIDLPKLIDRSVGNVINLTLFNKRFDMDKRDEFAHLKSL----IDGMRNVTSQFRYLIQYLVPWTSTVLPGPTLSEKVRAKR------EELDDFFYSQIDEHRNEID--FDNTENLDFVEAYLKEQKKREEDGDFKTFCNK-QLCAMLFDLWIAGLMTTTMTMTWGLSYYLYNPEVQRKIREELDKVIGNDRLISTADKNDLPYLQAFVTETQRTANIIPLNLIHMTTRDTVIDGFPIQKGTGVIAQISTVMYDEKVFPEPYKFKPERFIENGK--FKKVDEVIPFSIGKRQCLGEGLARIELFLFFANIFNRYDV 461          

Query:   36 MFIGILCFLIALLFLYHYYQRQKDPPGPIGWPVFGSTPERLY--WYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQES----EKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNIQVIGQDGNVNLLFFMRSIINFWIFRETFKSVR----------IYMDNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEI-KANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIK 1436
            +FI IL   + +L +  +   +K P GP+  P+ G+  +  Y  W   G      +   EMK++YG +++  +  +  +    Y++ YE+ V +   F NR       +Y+ +  GII   G +W  HR+  L      G+    IE K+++E     E   +  FK+    V +   +   V +II QL+++  FE DD++F  +   + +  ++ ++     +  ++  W+ +  F   R          IY    + +++ V + ++      + E D+         +++ +++S  E    ++   +  + FD++ AG +TT+  LCW  + L   P+   ++RNE+ +      +++     S  +  A ++E  R   ++   +   +E+     G  +            M  D + +K+ +EF+P RFM E  +L    K LI FGIGKRSC GE+LAR EL +I+ +I+  +EI+
Sbjct:    2 LFILILTATVLILTVNIWRAWRKLPNGPLPIPLIGNFHQLFYYAWRFGG----IVEGIKEMKKQYGKVFTLWMGPLPMVNICDYDIAYETHVKRANIFVNRYIH-GATEYIREGRGIIGSNGDFWLEHRRFALTTFRNFGIGRNIIEGKIMEEYNYRFEDFHETHFKNGAIQVSASMFFDLLVGSIINQLLVSERFEQDDKEFEELKTKLTMALENSSI-----IEGVMPLWLLKSKFMKWRTKTTFAPFDFIYEVGQKGIQRRV-AAIENGTHVLSEEGDD----FVDAFIIKIEKDSKEEVESTFTLETLAVDLFDLWVAGQETTSTTLCWAFVCLMNYPEVVEKLRNELTEVTGGMRSVSLADRSSTLYLNATINEIQRIASILNVNLPRVLEEDALIDGVLVPAGTAFATQLSAMHTDDETFKNHKEFNPERFM-ENNNL---EKKLIPFGIGKRSCPGESLARAELYLIIANIVMEYEIE 467          

Query:   75 FLYHYYQRQKDPPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXYWKAHRK---DTLKI--MHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFIN----VIKNIQVIGQDGNVNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYS----KHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEIKANKSNSAMNFNTTKSFHFF---KAFLDECFRYFPVIQRA-VHAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQN 1448
             + +Y + +K PPGP G PV G      Y    G E  +   + E+ ++YG+L+S +L     +V + Y++I E    +  +F+ RP D P M  ++  G I   G   WK  R+   D L+   M  +G     ++ +++ E  + +  +  S  +PV    + S  V N+IC LM++  F  DD KF      + + +++ G+   V+ +  M+   +    +           N  E++++ +  +D     F+P  +N   +++ YL   ++ ++ G  ++L+     + Q+++   D++ AG++T    L W  + +   P    R+++E+  ++        T +   +    ++ + E  R   ++  A  H+  + ++  G+ +     ++    ++  DP++W+ PEEF P RF+D    + KP ++ I FG+G+R C+G+ LAR EL +   S +  F+I L + 
Sbjct:   43 LVRNYRELRKLPPGPWGLPVIG------YLLFMGSE--KHTRFMELAKQYGSLFSTRLGSQLTVVMSDYKMIRECF--RREEFTGRP-DTPFMQTLNGYGIINSTGK-LWKDQRRFLHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDPKFRRFNFLIEEGMRLFGEIHTVDYIPTMQCFPSISTAKNKIAQ------NRAEMQRFYQDVIDDHKRSFDP--NNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWINVFMLRNPKEMRRVQDEL--DQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKP-EYFIPFGVGRRMCLGDVLARMELFLFFASFMHCFDIALPEG 494          

Query:   75 FLYHYYQRQKDPPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXYWKAHRK---DTLKI--MHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFIN----VIKNIQVIGQDGNVNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYS----KHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEIKANKSNSAMNFNTTKSFHFF---KAFLDECFRYFPVIQRA-VHAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQN 1448
             + +Y + +K PPGP G PV G      Y    G E  +   + E+ ++YG+L+S +L     +V + Y++I E    +  +F+ RP D P M  ++  G I   G   WK  R+   D L+   M  +G     ++ +++ E  + +  +  S  +PV    + S  V N+IC LM++  F  DD KF      + + +++ G+   V+ +  M+   +    +           N  E++++ +  +D     F+P  +N   +++ YL   ++ ++ G  ++L+     + Q+++   D++ AG++T    L W  + +   P    R+++E+  ++        T +   +    ++ + E  R   ++  A  H+  + ++  G+ +     ++    ++  DP++W+ PEEF P RF+D    + KP ++ I FG+G+R C+G+ LAR EL +   S +  F+I L + 
Sbjct:   43 LVRNYRELRKLPPGPWGLPVIG------YLLFMGSE--KHTRFMELAKQYGSLFSTRLGSQLTVVMSDYKMIRECF--RREEFTGRP-DTPFMQTLNGYGIINSTGK-LWKDQRRFLHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDPKFRRFNFLIEEGMRLFGEIHTVDYIPTMQCFPSISTAKNKIAQ------NRAEMQRFYQDVIDDHKRSFDP--NNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWINVFMLRNPKEMRRVQDEL--DQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKP-EYFIPFGVGRRMCLGDVLARMELFLFFASFMHCFDIALPEG 494          

Query:  402 WKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNII-CQLMLNRSFEYDDQKFINVI-------KNIQVIGQDGNVNLLFFMRSI----INFWIFRETFKSV-RIYMDNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEIKANKSNSAMN----FNTTKSFHFFKAFLDECFRYFPVI-----QRAVHAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAPLEHEIIYI 1529
            W  HR   +K M  +G     +E  +  E+E+LL ++ ++  +P++     ++ V+N++ C +   R    +D     ++       K   + G  G +    ++R +      + + ++    +   +MD +EE  + +           +P     S ++  YL   K + + GESS  +++ Q++    D + AG  TT++ +    ++L ++PD Q ++ +++ A+ + ++ +     +  ++F +  AF+ E  R+F +      +RA+ A +      G+ +     +++  +++  D + WK P EF P RF+D     +K +++ + FG+G+R C+G+ LAR  +   L+ I+Q+F + L      ++ L+     G+   P  +++ ++
Sbjct:  126 WYEHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLWCLIAGKRIARQEDGTLRRLLDLMNRRSKLFDICG--GLLAQFPWLRHVAPDRTGYNLIQQLNTELYGFFMDTIEEHRRQLAK---------DPS-PAESDLIYAYLQEMKDRSAGGESST-FNETQLVMTILDFFIAGSQTTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIMEVQRFFHITPITGPRRALWATK----LGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGKCFK-DEYFMPFGMGRRRCLGDALARACIFSFLVRIVQHFSVVLPAGESPSMVLL----PGITLTPKPYKVQFV 501          

Query:   33 FMFIGILCFLIALLFLYHYYQRQKDPPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQ-----------FSNRPKDLPI-MDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQE----IFKSANKPVKSD--KLYSKPVMNIICQLMLNRSFEYDD-------QKFINVIKNIQVIGQD-GNVNLL-FFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEIKA----------NKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAVHAVEKPIDFKGFHLVPRDLLMMD-FKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEI 1433
            +  I I C  +  +      + ++ PPGP  +P+ GS            + SQ +C   M  K   +++R+  ++    F   ++  + +VI  T               RP  +   +   + + G++   G+ W   R+  L+ +   G     + D V  E+  LLQ+    + KS  K  + +   L S  V+N +  ++  R +E          + F  + KNI ++G    +  LL F   +   +  F E+ +S+  +M    EL +                +D P  +++ YL  + Q E N E   ++S   ++  C D++ AG +TT   L +C + L L+P+ Q R   EIK           ++  + + +    +    + F+      F +  RAV          G+  +P+D +++  F+ M  +P  +  PE F+P R++ +  HL  P +    FG G+  CMG+ L R  L +   +++QNF++
Sbjct:    3 YTVIWIFCATLLAILFGGVRKPKRFPPGPAWYPIVGSA----------LQVSQLRCRLGMFCKVIDVFARQ--YVNPYGFYGLKIGKDKVVIAYTNDAISEMMTNEDIDGRPDGIFYRLRTFNSRLGVLLTDGEMWVEQRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVLNTLWCMLSGRRYEPGSPEITQLLETFFELFKNIDMVGALFSHFPLLRFIAPNFSGYNGFVESHRSLYTFMSKEIELHRLTYKN-----------YDEPRDLMDSYL--RAQDEGNDEKG-MFSDQSLLAICLDMFLAGSETTNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFM---LHTFGIPHRAVCDTR----LSGYE-IPKDTMVIACFRGMLINPVDFPDPESFNPDRYLFDG-HLKLP-EAFNPFGFGRHRCMGDLLGRQNLFMFTTTVLQNFKM 471          

Query:   33 FMFIGILCFLIALLFLYHYYQRQKDPPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQ-----------FSNRPKDLPI-MDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQE----IFKSANKPVKSD--KLYSKPVMNIICQLMLNRSFEYDD-------QKFINVIKNIQVIGQD-GNVNLL-FFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEIKA----------NKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAVHAVEKPIDFKGFHLVPRDLLMMD-FKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEI 1433
            +  I I C  +  +      + ++ PPGP  +P+ GS            + SQ +C   M  K   +++R+  ++    F   ++  + +VI  T               RP  +   +   + + G++   G+ W   R+  L+ +   G     + D V  E+  LLQ+    + KS  K  + +   L S  V+N +  ++  R +E          + F  + KNI ++G    +  LL F   +   +  F E+ +S+  +M    EL +                +D P  +++ YL  + Q E N E   ++S   ++  C D++ AG +TT   L +C + L L+P+ Q R   EIK           ++  + + +    +    + F+      F +  RAV          G+  +P+D +++  F+ M  +P  +  PE F+P R++ +  HL  P +    FG G+  CMG+ L R  L +   +++QNF++
Sbjct:    3 YTVIWIFCATLLAILFGGVRKPKRFPPGPAWYPIVGSA----------LQVSQLRCRLGMFCKVIDVFARQ--YVNPYGFYGLKIGKDKVVIAYTNDAISEMMTNEDIDGRPDGIFYRLRTFNSRLGVLLTDGEMWVEQRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVLNTLWCMLSGRRYEPGSPEITQLLETFFELFKNIDMVGALFSHFPLLRFIAPNFSGYNGFVESHRSLYTFMSKEIELHRLTYKN-----------YDEPRDLMDSYL--RAQDEGNDEKG-MFSDQSLLAICLDMFLAGSETTNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFM---LHTFGIPHRAVCDTR----LSGYE-IPKDTMVIACFRGMLINPVDFPDPESFNPDRYLFDG-HLKLP-EAFNPFGFGRHRCMGDLLGRQNLFMFTTTVLQNFKM 471          

Query:   36 MFIGILCFLIALLFLYHYYQRQKDPPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXY-WKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNI-QVIGQDGN-VNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEI-KANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKL-TQNTLENINLIIS 1478
            +F+G++  ++  +F    Y   + PPGP   P  G+ P  L           S  +     +YG + +  L     +V  + ++I E++V  GT  S RP  +PI+ ++++  GI+     + W+  R+  L  +   G+   ++E++V +ES  L+ E+ K   KP          V NIIC ++    FEYD+++F  +++ I + I Q G+ +  +F +  II  +         +IY  N EEL+ ++     +  E  +P  D+P   ++ YL+  ++Q+S+ +SS  + +  ++ +  D++ AG DTT   + W  + L   PD Q R   EI +    +     +      +  A + E  R   ++  +V H   +P+  +G+ +     ++++   +  + + WKHP+ F+P  F+D+  H Y+P   L  F +G R C+GE LA+ EL + + S++Q       T     N++ I+S
Sbjct:   17 LFLGLIFLVVFEIFRIRSYS-GRFPPGPTPLPFVGTIPHFL---------KDSMGFIRSLSQYGEMTTVYLGRKPAMVLNTLQVIKEAIVQNGTSSSGRPS-IPILTWITEGYGIVLATFGHSWRQQRRFALHTLRNFGLGKKSVEERVTEESGYLVPEMLKLEGKPFDPQHAIQNAVSNIICSIVFGDRFEYDNKRFEYLLEIIKENINQAGSLIGQVFNLIPIIKHF----PGPHQKIY-QNAEELKSFIRESTKSHRETLDP--DSPRDFIDAYLLEMEKQKSSQDSS--FHEDNMVMSVADLFLAGSDTTATTIRWGLIYLTQNPDVQERCHEEIVRVLGYDRLPCMDDRDRLPYTLATVHELQRCGNIVPSSVPHETTQPMKLRGYDIPQGTQMLINLSDILANKEHWKHPDTFNPENFLDDKGHFYRPEAFL-PFSLGPRVCLGETLAKTELFLFITSLLQRIRFSWPTGEKWPNMDGIVS 482          

Query:   36 MFIGILCFLIALLFLYHYYQRQKDPPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXY-WKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNI-QVIGQDGN-VNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEI-KANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKL-TQNTLENINLIIS 1478
            +F+G++  ++  +F    Y   + PPGP   P  G+ P  L           S  +     +YG + +  L     +V  + ++I E++V  GT  S RP  +PI+ ++++  GI+     + W+  R+  L  +   G+   ++E++V +ES  L+ E+ K   KP          V NIIC ++    FEYD+++F  +++ I + I Q G+ +  +F +  II  +         +IY  N EEL+ ++     +  E  +P  D+P   ++ YL+  ++Q+S+ +SS  + +  ++ +  D++ AG DTT   + W  + L   PD Q R   EI +    +     +      +  A + E  R   ++  +V H   +P+  +G+ +     ++++   +  + + WKHP+ F+P  F+D+  H Y+P   L  F +G R C+GE LA+ EL + + S++Q       T     N++ I+S
Sbjct:   17 LFLGLIFLVVFEIFRIRSYS-GRFPPGPTPLPFVGTIPHFL---------KDSMGFIRSLSQYGEMTTVYLGRKPAMVLNTLQVIKEAIVQNGTSSSGRPS-IPILTWITEGYGIVLATFGHSWRQQRRFALHTLRNFGLGKKSVEERVTEESGYLVPEMLKLEGKPFDPQHAIQNAVSNIICSIVFGDRFEYDNKRFEYLLEIIKENINQAGSLIGQVFNLIPIIKHF----PGPHQKIY-QNAEELKSFIRESTKSHRETLDP--DSPRDFIDAYLLEMEKQKSSQDSS--FHEDNMVMSVADLFLAGSDTTATTIRWGLIYLTQNPDVQERCHEEIVRVLGYDRLPCMDDRDRLPYTLATVHELQRCGNIVPSSVPHETTQPMKLRGYDIPQGTQMLINLSDILANKEHWKHPDTFNPENFLDDKGHFYRPEAFL-PFSLGPRVCLGETLAKTELFLFITSLLQRIRFSWPTGEKWPNMDGIVS 482          

Query:   36 MFIGILCFLIALLFLYHYYQRQKDPPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXY-WKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKF---INVIK-NIQVIGQDGN--VNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEI-KANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKL-TQNTLENINLIIS 1478
            +F+G+ C  +  +     Y + + PPGP   P  G+ P  L              +     +YG + +  L     I+  + +L+ E+ V  G+ FS RP  +P++ +V++  GII     + W+  R+  L  +   G+   ++E++V +ES  L+ E+ +   KP            NIIC ++    F+YD++ F   + +IK N+ + G      VNL+  ++++             +IY  N EE + ++   + A  E  +P  D+P   ++ YL+  ++Q+S  +S+  + +  ++ +  D++ AG DTT   + W  L L   PD Q R  +EI +    +   + +      +  A + E  R   V    V H   KPI  +G+ +     ++++   +  + + WKHP+ F+P  F+D+  H +KP   L  F +G R+C+GE LA+ EL + + S++Q       T     ++N I+S
Sbjct:   17 LFLGLFCLALFEICRIRIY-KGRYPPGPTPLPFVGTIPHFL---------KNPMGFIRSLSQYGEMTTVYLGRKPAIILNALQLMKEAFVQNGSSFSGRPP-VPVLTWVNQGYGIIMAMDGHSWRQQRRFALHTLRNFGLGKKSVEERVTEESGYLISELLRVEGKPFNPQHAIHNAAANIICSIVFGDRFDYDNKSFTYLLEIIKENLDLAGSFAGQMVNLVPIIKNLPG--------PHQKIY-QNGEEFKSFIRESVKAHRETLDP--DSPRDFIDAYLLEMEKQKSTQDST--FHEDNMVMSVGDLFFAGTDTTATTIRWGLLYLTQNPDVQERCHDEIVQVLGFDCFPSMDDRDQLPYTLATVHEIQRCANVAPSGVPHQTTKPIKLRGYDIPQGTQILINLMGILANKEHWKHPDTFNPENFLDDKGHFFKPEAFL-PFSLGPRACLGETLAKTELFLFVTSLLQRIRFSWPTGEKWPDMNRILS 482          

Query:   36 MFIGILCFLIALLFLYHYYQRQKDPPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXY-WKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIK----NIQVIGQDGN--VNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEI-KANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAVHAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAPLEHEII 1523
            +F+G L FL+       Y  + + PPGP   P  G+ P  L              +     +YG L +  +     I   + +L  E+LV     FS RP  LPI D++S   GII +   + W+  R+  L  +   G+   T+ED+V++ES+ L+ E+ K   K +         V NIIC ++    FEYD+++F  ++K    NI + G       NL+ F++       F    + ++    N ++L  ++  +     +  +P  D+P   ++ YL+  ++Q+ N +S+  + +  ++ +  D++ AG DTT   + W  + L   PD Q R   EI +    +   + +      +  A + E  RY  +  + +H   +     G+ +     ++ +F  M  D ++WKHP+ F+P  F+DE     KP ++   F +G R+C+GE LAR EL + + S++Q        N      + + G  G++ +P    II
Sbjct:   17 LFLG-LIFLVLFEIFRIYSYKGRFPPGPTPLPFVGNLPHLL---------KNPMGFKRSLSEYGGLATVFIGRKPAISINTIQLAKEALV--QDVFSGRPA-LPIFDWISHGLGIIMVTFNHSWRQQRRFALHTLRNFGLGKKTVEDRVLEESQYLIAEMLKDEGKSMNPQHALQNAVSNIICSIVFGDRFEYDNKRFEYLLKILNENIMLTGSAAGQIYNLVPFIKH------FPGPHQKIK---QNADDLFNFIRDEAKEHKQTLDP--DSPRDFIDAYLLEIEKQKFNKDST--FHEEHLVVSTSDLFLAGTDTTETTIRWGLIYLIQNPDVQERCHEEIVQVLGYDRLPSMDDRDKLPYTLATVHEIQRYGNIAPKLLHETIRRTKLHGYDIPQGTTIIANFTAMFSDKELWKHPDAFNPENFLDENGQFSKP-EYFFPFSLGPRACLGETLARTELFLFITSLLQRIRFSWPPNAKP---IDMDGIVGIVRSPEPFNII 490          

Query:   36 MFIGILCFLIALLFLYHYYQRQKDPPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXY-WKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNI-QVIGQDGNVNLLFFMRSIINFWIFRETFKSVRIYM-DNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEI-KANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAVHAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAPLEHEII 1523
            +F+G++  ++  +F  H Y+R + PPGP   P  G+ P  L              +     +YG + +  L     I   + +L  E+LV Q T FS +P  LP+++++SK  GI  +   + W+  R+  L  +   G+   ++ED+V++ES  L+ E+ K   KPV         V NIIC ++    FEY++++F  ++K + + I   G+ +       I N   F + F      +  N ++L  ++  +++   +  +P   +P   ++ YL+  ++Q+ N +S+  + +  ++ +  D++ AG DTT   + W  L L   PD Q R   EI +    +   + +      +  A + E  RY  +I   +H    P   +G+ +     ++ + + +    D WKHP+ F+P  F+ E RH  KP +  I F +G RSC+GE LAR EL + + S++Q        +  + I++   G  GL+++P    +I
Sbjct:   17 LFLGLIILVLFEIFRIHSYKR-RTPPGPTPLPFVGTIPHFL---------KNPLGFIRSMSQYGDMSTMYLGRKPAIFLNTIQLAKETLV-QDT-FSGKPY-LPVIEWISKGFGIAMVTFNHSWRQQRRFALHTLKNFGLGKKSVEDRVLEESRYLIAEMLKDEGKPVDPHHPIQNAVSNIICSIVFGDRFEYNNKRFEYLLKMLNETIMLAGSAS-----GRIFNLVPFIKHFPGPHQKIKKNTDDLLIFLGDEVEEHRKTLDP--GSPRDFIDAYLLEIEKQKFNKDST--FHEGNLLASAGDLFMAGTDTTETTIRWGLLFLIQNPDVQERCHEEIVQVLGYDRLPSMDDRDRLPYTLATVHEIQRYGNIIPILIHETILPTKLQGYSIPQGTTIVTNIQAIFSSKDHWKHPDSFNPENFL-EDRHFIKP-ESFIMFSLGPRSCLGEILARTELFLFITSLLQRIHFSWPPDA-KPIDM--DGIFGLVHSPQAFNVI 489          

Query:   54 CFLIALLFLYHYYQRQKDPPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIK----NIQVIGQDGNVNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEIKANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAPLEHEIIYIP 1532
            C  +  +F       Q  PPGP   P+ G+    L+     + +     + E  +KYG ++S +L   + IV    + + ++L+  G +FS RPK +P+ D +SK  G++F  G+ WK  R+  L  +   GM   TIED +V+ES  L++       KP  +  + +  V NII  ++LN  FEY D   I +IK    N+++ G    + +L+     I  WI      S +   +N ++L  +++       ++   + ++   +++ +LV  KQQE    S   +    +     D++ AG++TT+  L W  LM+   PD Q ++++EI     ++       K   +  A + E  R+  ++   + H++ + + F+G+ L     ++    ++ +D D ++ PEEF P  F+D   +  K N+  + F +GKRSC+GE LA+ EL +    ++QNF    T      + + ++  + L   PL+H+I  +P
Sbjct:   13 CIFLYKVFYGGKGASQNFPPGPKPLPLIGN----LHMMNMKKPHL---TFMEFSKKYGPVFSIQLGLNKAIVLCGADAVKDALINHGDEFSGRPK-IPVFDQISKGYGVVFADGENWKVMRRFALSTLRDFGMGRKTIEDTIVEESGCLVETFKSHEAKPFDNTLILNAAVANIIVHILLNHRFEYQDPTLIKLIKSVSENVKIAGSP--IVMLYNTYPSIMGWI----PGSHKTVFENFQKLSNFLKETFTKRRDQL--DVNDQRDLIDAFLV--KQQEEKSSSKKFFHDENLKVLLGDLFAAGMETTSTTLRWGILMMMKYPDIQKKVQDEIDRVIGSAEPRLEHRKQIPYTDAVIHEIQRFANLVPIVLPHSITEDVTFRGYFLPKGTQVIPLLISVMQDKDYFQKPEEFYPEHFLDSKGNFVK-NEAFLPFSVGKRSCVGETLAKMELFLFFTKLLQNF----TFQPPPGVEVQLTCGDALTSIPLDHQICALP 487          

Query:   39 FIGILCFLIALLFLYHYY-----QRQKDPPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKS-ANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQ---KFINVI-KNIQVIGQDGNVNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEIKANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAVHAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAPLEHEIIYIP 1532
             + +L  ++  +FLY  +     + Q  PPGP   P+ G+      +++   +      + E+ +KYG+++S +L   + +V    + + ++LV    +FS RP  +P+ D  SK  G+ F  G+ WK  R+ TL  +   GM   TIED++ +ES+  L E FKS   KP  +  + +  V NII  ++LN  F+Y D    K IN++ +NI +  +   + LL+     I  W+   T KSV    +N+ +L  ++      T  +   + ++   +++ +LV  KQQE    S+  ++   +     D++GAG++TT+  L W  L +   PD Q ++++EI     ++       K   +  A + E  R   +     H     + F+G+ +     +++   ++ +D D +K PEEF P  F+D   +  K N+  + F  G+R C+GE LA+ EL +    ++QNF    T      + + ++  + +   PLEH+I  +P
Sbjct:    3 LVSVLLSVVICIFLYKVFYGGEKESQNFPPGPKPLPIIGN------FHMINMKKPHL-TFMELAKKYGSVFSIQLGPEKLVVVCGADAVKDALVNHADEFSARPT-IPVFDKTSKGHGVFFANGENWKVMRRFTLSTLRDFGMGKKTIEDRICEESD-FLMETFKSYKGKPFDNTMIMNAAVANIIVHILLNHRFDYQDPTLLKLINIVSENISIAAKP--IVLLYNAYPSIMEWV-PGTHKSV---AENMLKLYNFLRETF--TQHRDQLDVNDQRDLIDVFLV--KQQEEKPSSTKFFNDQNLTVLLADLFGAGMETTSTTLRWGLLFIMKYPDIQKKVQDEIDKVIGSAQPRLEHRKKMPYTDAVIHEIQRLGNLAPNVGHETTTDVTFRGYFIPKGTQVIILLTSVLQDKDYFKKPEEFYPEHFLDSEGNFVK-NEAFLPFSAGRRICVGETLAKMELFLFFTKLLQNF----TFQPPPGVEVDLTCADAITSKPLEHQICALP 486          

Query:   48 ILCFLIALLFLYHYYQRQKD----PPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKS-ANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIK----NIQVIGQDGNVNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEIKANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAPLEHEIIYIP 1532
            +L   + +  L  +Y  + D    PPGP   P+ G+        L          + E+ EKYG+++S  L   + +V    + + E+L+    +FS RPK +PI + VSK  G+IF  G+ WK  R+ TL  +   GM   TIE+++ +ES+ L+ E FKS   KP ++  + +  V NII  ++L   F+Y D   + +IK    N++++G    + +L+     +  W+  +     +   +N  +L K++E       ++   + ++   +++ +LV  KQQE    SS  +    +     +++GAG++TT+  L W  L++   PD Q ++++EI     ++       K   +  A + E  R+  +    + HA    + F+G+ +     ++    ++ +D + +K PEEF P  F+D   H  K N+  + F  G+RSC GE LA+ EL +    ++QNF    T      + + ++  EG   +PL+H I  +P
Sbjct:    7 LLSIAVCVFLLNLFYGGKGDSKMFPPGPKPLPLIGN-------LLIMNMKKPHLTFMELAEKYGSVFSVHLGTEKVVVLCGTDAVKEALINHADEFSERPK-IPIFEDVSKGYGLIFSHGENWKVMRRFTLTTLRDFGMGKKTIEERICEESDCLV-EAFKSYKGKPFENTLIMNAAVANIIVSILLGHRFDYQDTALLKLIKIINENVRLMGSP--MVMLYNTYPSVMQWLPGKH----KTVAENTLKLFKFLEETFTKHRDQL--DVNDQRDLVDTFLV--KQQEEKPSSSKFFHDQNLTLLVSNLFGAGMETTSTTLRWGLLLMMKYPDIQKKVQDEIDKVIGSAEPQTEHRKLMPYTDAVIHEIQRFANIAPSNLPHATTTDVTFRGYFIPKGTQVIPLLTSVLQDKNYFKKPEEFYPEHFLDSEGHFMK-NEAFLPFSAGRRSCAGETLAKMELFLFFTKLLQNF----TFQPPPGVEVQLTSGEGFTSSPLQHNICALP 487          

Query:   21 LNF*FMFIGILCFLIALLFLYHYYQRQKD---PPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVI----KNIQVIGQDGNVNLLFFMRSIINFWIFRETFKSVRIYMD-NLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEIKANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAPLEHEIIYIP 1532
            ++F F     L  ++ +L++   ++R+     PPGP GWP+ G+         +       + Y E+ +KYG ++S ++   + ++   YE + ++LV    +F  R   +P+   + K  GI F  G+ WKA R+ T+  +   GM   TIE+ +  E   L+Q       KP  +  + S  V NII  ++     EY+D  F+ ++    + ++++G          M +I N +            ++ NL+EL  +V        +    +  +    ++ +L  QK++  + E+   +    ++R   +++ AG++TT+  L W  L++   PD Q ++ +EI     ++   ++      F  A + E  R+  ++  +V H   + + FKG+ +     ++    ++ KD   +  PEEF+P  F+D   +  K  +  + F  G+R+C GE LAR EL I   S++Q F    +   + NINL  S   G    PLE  I  IP
Sbjct:    1 MDFTFSLATYLVLVVTVLYILSNWKRKALNNFPPGPKGWPLVGNV-------FSIDLKKPQRTYIELSKKYGPVFSVQMGRKKMVILVGYETVKDALVTHAEEFGGR-ASIPVNKNLEKGLGITFSNGENWKAMRRFTITTLKDFGMGKSTIEETIAHECSYLVQYFASFKGKPFDNSTILSTSVANIIAPILFGHRMEYEDPVFLRLVNLNSEYVKLLGSP--------MVTIYNMFPALGFLPGCHKTIEKNLKELYAFVRRTFVEHQKHL--DIHDQRSFIDVFLARQKEEAKHPETKSYFHNENLVRLVRNVFSAGMETTSTSLRWALLLMIKYPDIQEKVHDEISRVIGSAHPTYSHRTQMPFTNAVIHEILRFADIVPLSVPHETTRDVHFKGYFIPKGTYIIPLLSSVLKDKTQFDAPEEFNPNHFLDSEGNFLK-KEAFMPFSAGRRACPGEILARMELFIFFTSLLQKFSFH-SPPGVTNINL--SSDVGFTSVPLEGMICAIP 491          

Query:   54 CFLIALLFLYHYYQRQKDPPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNIQVIGQDGNVNLLFFMR---SIINFWI---FRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEIKANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAPLEHEI 1520
            C  +  +F     + Q  PPGP   P+ G+    L+     + Y     + E+ +KYG ++S +L   + +V    + + ++L+    +FS RPK  P+ +  SK  GIIF  G+ WK  R+ TL  +   GM   TIED++ +ES+ L++       KP  +  + +  V NII  ++LN  F+Y D  F+ +IK++    ++G   ++       SII  WI    +  F S + + + L+E+    + QLD   ++          +++ +LV  KQQE    S+  +    +     +++GAG++TT+  L W  L++   P+ Q ++++EI     ++       K   +  A + E  R+  ++   V HA    + F+G+ L     +     ++ +D   +K P+EF P  F+D   +  K N+  + F  GKR C GE LA+ EL +    ++QNF    T      + + ++  E +   PL+H+I
Sbjct:   13 CIFLFKVFFGGEKESQNFPPGPKPLPLIGN----LHIMNMKKPYL---TFMELAKKYGPVFSVQLGTKKTVVLCGTDAVKDALINYADEFSGRPK-TPLSEQASKGNGIIFANGENWKVMRRFTLSTLRDFGMGKKTIEDRISEESDCLVETFKSHKGKPFDNTLILNAAVANIIVHILLNHRFDYQDPTFLKLIKSVNDNVRNGARPIIVLYNAFPSIIR-WIPGTHKRIFASSQNFFNFLKEIFMKRKDQLDVNDQR---------DLVDAFLV--KQQEEKSSSTKFFHDENLKVLIGNLFGAGMETTSTTLRWGILLMMKYPEIQKKVQDEIDRVMGSTEPRPEHRKQMPYTDAVIHEIQRFADLVPNGVPHATTTDVTFRGYFLPKGTQVFPLLTSVLRDKAYFKKPDEFYPEHFLDSEGNFLK-NEAFLPFSAGKRICAGETLAKMELFLFFTKLLQNF----TFQPPPGVEVQLTRGEAITSIPLDHQI 483          

Query:   87 YYQRQKD---PPGPIGWPVFGS-----TPERL---YWYLTGRE---YSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXX-XXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNIQVIGQDGNVNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFD--NPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEI-KANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAP 1505
            + +RQ+    PPGP   P+ G+      P  L   +W  +G +     Q    + M   YG ++S  + H   +V + +  + E+LV Q   FS+RP+ +P++  ++K+ GI+    G  WK  R+ +   +   G+  L++E ++++E   + + + K    P     + S  V NIIC L   + F+Y +++F  V+ +    G +  ++   F+ +I   W +   F   +     L ++E+ +   L     +     D  NP   ++ YL L  ++E        + +  +     D++ AG DTTT+ L WC L + L PD Q ++  EI +    + A +        + +A + E  R   V+  A+ H   +    +GF +    +++++  ++ +DP IW+ P++F P RF+D+   L K  +  I FGIGKR CMGE LA+ EL ++ +S++Q F   L + + +    +++G  GL  AP
Sbjct:   41 WLRRQRACGIPPGPKPRPLVGNFGHLLVPRFLRPQFWLGSGSQTDTVGQHVYLARMARVYGNIFSFFIGHRLVVVLSDFHSVREALVQQAEVFSDRPR-MPLISIMTKEKGIVFAHYGPIWKQQRRFSHSTLRHFGLGKLSLEPRIIEEFAYVKEAMQKHGEAPFSPFPIISNAVSNIICSLCFGQRFDYTNKEFKKVL-DFMSRGLEICLHSQLFLINICP-WFYYLPFGPFK----ELRQIERDISCFLKNIIREHQESLDASNPQDFIDMYL-LHMEEEQGASRRSSFDEDYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQKKVHEEIERVIGCDRAPSLTDKAQMPYTEATIMEVQRLSMVVPLAIPHMTSEKTVLQGFTIPKGTVVLINLWSVHRDPAIWEKPDDFCPHRFLDDQGQLLK-RETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQTFTFALPEGSEKP---VMTGRFGLTLAP 520          

Query:   87 YYQRQKD---PPGPIGWPVFGS-----TPERL---YWYLTGRE---YSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXX-XXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNIQVIGQDGNVNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFD--NPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEI-KANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAP 1505
            + +RQ+    PPGP   P+ G+      P  L   +W  +G +     Q    + M   YG ++S  + H   +V + +  + E+LV Q   FS+RP+ +P++  ++K+ GI+    G  WK  R+ +   +   G+  L++E ++++E   + + + K    P     + S  V NIIC L   + F+Y +++F  V+ +    G +  ++   F+ +I   W +   F   +     L ++E+ +   L     +     D  NP   ++ YL L  ++E        + +  +     D++ AG DTTT+ L WC L + L PD Q ++  EI +    + A +        + +A + E  R   V+  A+ H   +    +GF +    +++++  ++ +DP IW+ P++F P RF+D+   L K  +  I FGIGKR CMGE LA+ EL ++ +S++Q F   L + + +    +++G  GL  AP
Sbjct:   41 WLRRQRACGIPPGPKPRPLVGNFGHLLVPRFLRPQFWLGSGSQTDTVGQHVYLARMARVYGNIFSFFIGHRLVVVLSDFHSVREALVQQAEVFSDRPR-MPLISIMTKEKGIVFAHYGPIWKQQRRFSHSTLRHFGLGKLSLEPRIIEEFAYVKEAMQKHGEAPFSPFPIISNAVSNIICSLCFGQRFDYTNKEFKKVL-DFMSRGLEICLHSQLFLINICP-WFYYLPFGPFK----ELRQIERDISCFLKNIIREHQESLDASNPQDFIDMYL-LHMEEEQGASRRSSFDEDYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQKKVHEEIERVIGCDRAPSLTDKAQMPYTEATIMEVQRLSMVVPLAIPHMTSEKTVLQGFTIPKGTVVLINLWSVHRDPAIWEKPDDFCPHRFLDDQGQLLK-RETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQTFTFALPEGSEKP---VMTGRFGLTLAP 520          

Query:   93 QRQKDPPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNIQVIGQDGNVNLLF--FMRSIINFWIFRE-----------TFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEIK--ANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAPLEHEIIYIPI 1535
            +R + PPGP  +P+ G+     +  +  + ++QS   +   + YG +++  L     +V   YE + E+L+  G +FS R +++P+ + ++   GI F  G  WK  R+ TL  +  LGM    IED+V +E++ L++E+ K+   P     + S    N+IC ++    F+Y D+ F+ ++K +     + NV +L   +++   NF +  +            FK +R Y+  LE++++  ES LD T         NP   ++++L+  KQ+++N      YS   ++    +++ AG +TT+  L +  L+L   PD   +++ EI     +  S    + ++   +  A + E  R+  ++   + HAV   I F+ + +     ++    ++  D   + +PE FDP  F+D   + +K + + + F  GKR C GE LAR EL +IL +I+QNF++K   +  ++I++ I    GLI  P  +++ +IP+
Sbjct:   25 RRGRLPPGPTPFPIIGN-----FLQIDVKNFNQS--LTNFSKTYGPVFTLYLGSRPIVVLHGYEAVKEALIDHGEEFSGR-ENIPMSEKINNGLGITFSNGNSWKETRRFTLMTLRNLGMGKRNIEDRVREEAQCLVEELRKTKGSPCDPTFILSCAPCNVICSIIFQDRFDYKDKDFLMLMKKL-----NENVKILSSPWLQVCNNFPLLIDYCPGSHHKVLKNFKYIRSYL--LEKVKEHQES-LDVT---------NPRDFIDYFLI--KQKQANHIEQAEYSLENLVCTINNLFAAGTETTSTTLRYALLLLMKYPDVTAKVQEEIDHVVGRHRSPCMQDRSR-MPYTDAMIHEVQRFINLVPNNLPHAVTCDIKFRNYIIPKGTTVVTSLTSVLHDSKEFPNPEMFDPGHFLDANGN-FKKSDYFMTFSAGKRVCAGEGLARMELFLILTTILQNFKLKSLVHP-KDIDM-IPFVNGLITLPPHYQLCFIPL 490          

Query:   48 ILCFLIALLFLYHYYQRQKD---PPGPIGWPVFGSTPERLYWYLTGREYSQSK-CYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNIQVIGQDGNVNLLFFMRSIIN------FWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEI-KANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAPLEHEIIYIP 1532
            +L   +  L L  Y++ ++    PPGP G P  G+        +   ++ Q       + +KYG ++S  L  I  +V     LI E+L        NRP  + + + +S K G+IF  G+ WK  R+  L  +   G+   ++E+++ +E+  L++ I +   KP       +  V NIIC +     F+Y D +F  +++ +  +        ++   ++I+       WI +    S +    N E+L+ +V   +D   + +NP  D P   ++ +L   K+     E +  +++  +I +  D++ AG +TT+  L W  L + L P+ Q +++ EI +      A      +S  +  A + E  R   +I   V   V    +  GFHL    +++ +   + +DP  W  P+ F+P  F++  +  +K  +  + F +GKR+C+GE LAR EL I   S++Q F    T N   N  L      GL  +P+ H I  +P
Sbjct:   21 LLVAAVTFLLLADYFKNRRPKNYPPGPWGLPFVGN--------IFQLDFGQPHLSIQPLVKKYGNIFSLNLGDITSVVITGLPLIKEALTQMEQNIMNRPLSV-MQERISNKNGLIFSSGQIWKEQRRFALMTLRNFGLGKKSLEERMQEEASHLVEAIREEEGKPFNPHFSINNAVSNIICSVTFGERFDYHDSRFQEMLRLLDEV--------MYLETTMISQLYNIFPWIMKYIPGSHQKVFRNWEKLKLFVSCMIDDHRKDWNP--DEPRDFIDAFL---KEMTKYPEKTTSFNEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEVQEKVQAEIDRVIGQKRAARLADRESMPYTNAVIHEVQRMGNIIPLNVPREVAMDTNLNGFHLPKGTMVLTNLTALHRDPKEWATPDVFNPEHFLENGQ--FKKRESFLPFSMGKRACLGEQLARSELFIFFTSLMQKF----TFNPPINEKLSPKFRNGLTLSPVSHRICAVP 499          

Query:   33 FMFIGILCFLIALLFLYHYYQ-RQKDPPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKN----IQVIGQD-----GNVNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEIK-ANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQ-RAVHAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAPLEHEIIYIPI 1535
            F+F+GI       LFL++ ++ R K PPGP   P+ G+        L     + SK    + +KYG +++  L     +V   Y+ + E+L+ QG +FS++  D  ++   S+  GI+F  G+ WK  R+ +L ++  +GM   TIED++ +E   +L  + K+   P     L +    N+I  ++    F+Y+DQ F + ++N    I+++            +L+++  I N ++   T +   I    LEE+ +  +S           +  NP   ++++L+  ++++ N +S   ++   ++ +  D++GAG +TT+  + +  L+L   P+   +I+ EI      +            +  A L E  RY   +   +     + ++F+G+H+     +M    ++  D   + +PE+FDP  F+DE  + +K + + +AF  G+R+C+GE LAR E+ +IL +I+Q+F +K      E+I+     T GL++ P   E+ +IP+
Sbjct:    4 FIFLGIWLSCFLFLFLWNQHRGRGKLPPGPTPLPIVGNI-------LQVDVKNISKSMGMLAKKYGPVFTVYLGMKPTVVLHGYKAMKEALIDQGDEFSDK-TDSSLLSRTSQGLGIVFSNGETWKQTRRFSLMVLRSMGMGKKTIEDRIQEEILYMLDALRKTNGSPCDPSFLLACVPCNVISTVIFQHRFDYNDQTFQDFMENFHRKIEILASPWSQLCSAYPILYYLPGIHNRFLKDVTQQKKFI----LEEINRHQKSL----------DLSNPQDFIDYFLIKMEKEKHNQKSE--FTMDNLVVSIGDLFGAGTETTSSTVKYGLLLLLKYPEVTAKIQEEIAHVIGRHRRPTMQDRNHMPYTDAVLHEIQRYIDFVPIPSPRKTTQDVEFRGYHIPKGTSVMACLTSVLNDDKEFPNPEKFDPGHFLDEKGN-FKKSDYFVAFSAGRRACIGEGLARMEMFLILTNILQHFTLKPLVKP-EDIDTKPVQT-GLLHVPPPFELCFIPV 489          

Query:  108 PPGPIGWPVFGSTPERLYW-YLTGREYSQSKC---------------YSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXX-XXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNIQVIGQDGNVNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFD--NPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEI-KANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAP 1505
            PPGP  WP+ G+    L   +L  R +  S+                 + +   YG+++S  + H   +V + +  + E+LV Q   FS+RP+ +P++  V+K+ G++    G  W+  RK +   +   G+  L++E K+++E + +  E+ K    P     + S  V NIIC L   + F+Y + +F  ++      G +  +N    + +I   W++   F   +     L ++EK + S L    +      D  NP   ++ YL L  ++E    S+  + +  +     D++ AG DTTT+ L WC L + L PD Q ++  EI +   +N A +        + +A + E  R   V+  A+ H   +    +G+ +    L++ +  ++ +DP IW+ PE+F P RF+D+   L K  +  I FGIGKR CMGE LA+ EL ++ +S++Q+F   L +++ +    +++G  GL  AP
Sbjct:   60 PPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGIDPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPR-VPLISIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGEDPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKML-GFMSRGLEICLNSQVLLVNICP-WLYYLPFGPFK----ELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYL-LHMEEERKNNSNSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQLIK-KETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALPEDSKKP---LLTGRFGLTLAP 534          

Query:   90 YQRQKDPPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNIQVIGQDGNVNLLFFMRSIINF---WI-FRETFKSVRIYMDNLEELEKWVESQLDATCEKFNP-----EFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEI-KANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDL-LMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAPLEHEIIYIPI 1535
            Y R+K PPGP  +P+ G+        L     + SK  S + ++YG +++        +V   YE + E+LV  G +FS R   +P+ D  ++  G+    G+ WK  R+ TL ++  +GM   TIED++ +E+  L++ + ++   P     L      N+IC ++    FEY+DQ F  ++K+              F+ SI  F   W+    TF  +     +  EL K    Q+    EK        + +NP   +++ L+  ++++ N +S   ++ H ++   +D++ AG  TT+  + +  L+L   P+   +++ EI +    + +          +  A + E  RY  ++   V HAV + I F+G+ L+P+   ++    ++  D   + +PE+FDP  F+D + + +K + + + F IGKR+C GE LAR EL ++L +I+Q+F +K   +  +     +    G +  P  +E+ ++P+
Sbjct:   24 YARRKLPPGPTAFPLVGNV-------LQLDRKNISKSISMLAKEYGPVFTVYFGTKPSVVLHGYEAVKEALVDHGEEFSGR-VTVPVFDRYAQGAGLFASQGELWKETRRFTLTVLRNMGMGKKTIEDRIQEEASCLVKALKETNASPCDPSSLLFCVPCNVICSIIFQNRFEYNDQTFQTLVKH--------------FLDSIRLFNTPWMQLYNTFPILHYLPGSHHELFKVFNDQMKFFSEKIREHQESLDHNNPRDFIDYLLIKMEKEKHNKQSQ--FTMHHLLVTIWDVFDAGSQTTSSTMQFGLLLLMKHPEIAAKVQEEIERVIGRDRSPCMQDRSCMPYTDAVIHEIQRYIDMVPNNVPHAVTQDIQFRGY-LIPKGTHILPSLTSVLYDEKEFPNPEKFDPGHFLDASGN-FKKSDYFLPFSIGKRACAGEGLARMELFLVLTTILQHFTLKPLVDPKDIDPTPVDN--GFLSVPPSYELCFVPV 489          

Query:   33 FMFIGILCFLIALLFLYH-YYQRQKDPPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIK----NIQVIG----QDGNVNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEIK--ANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDL-LMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIK-------LTQNTLENINLIISGTEGLIYAPLEHEIIYIPI 1535
             + +GI    + LL L+   + + K PPGP   PV G+        L       +K  S + ++YG++++        +V   YE + E+L+ +G +FS R    P+ D V+K  GI+F  G+ WK  R+ +L ++  LGM   TIE+++ +E+  L+Q + K+   P     L      N+IC ++    F+YDD+KF  +IK    N +++G    Q  N+  +       +  +F+     ++  ++ ++E ++ ++S             +NP   ++H+L+  ++++   +S   ++   +I   +D++ AG DTT++ L +  L+L   P+   +++ EI+    +  S    + T+   +  A + E  RY  ++  ++ HAV + I+F G+ L+P+   ++    ++  D   + +PE+FDP  F+DE+ + +K + + + F  GKR+C+GE LAR EL ++L +I+Q+F +K       +    +EN         G +  P  +E+ ++P+
Sbjct:    4 LIILGICLSCVVLLSLWKKTHGKGKLPPGPTPLPVVGN-------LLQLETKDINKSLSMLAKEYGSIFTLYFGMKPAVVLYGYEGVIEALIDRGEEFSGR-GIFPVFDRVTKGLGIVFSSGEKWKETRRFSLTVLRNLGMGKKTIEERIQEEALCLIQALRKTNASPCDPTFLLFCVPCNVICSVIFQNRFDYDDEKFKTLIKYFHENFELLGTPWIQLYNIFPILHYLPGSHRQLFKNIDGQIKFILEKVQEHQESLDS-------------NNPRDFVDHFLIKMEKEKHKKQSE--FTMDNLITTIWDVFSAGTDTTSNTLKFALLLLLKHPEITAKVQEEIEHVIGRHRSPCMQDRTR-MPYTDAVMHEIQRYVDLVPTSLPHAVTQDIEFNGY-LIPKGTDIIPSLTSVLYDDKEFPNPEKFDPGHFLDESGN-FKKSDYFMPFSAGKRACVGEGLARMELFLLLTTILQHFTLKPLVDPKDIDPTPVEN---------GFVSVPPSYELCFVPV 489          

Query:  108 PPGPIGWPVFGSTP--------ERLYW-YLTGREYSQSKC-------YSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXX-XXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNIQVIGQDGNVNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFD--NPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEI-KANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAPLEHEII 1523
            PPGP  WPV G+           R  W Y   R    +          +++   YG ++S  + H   +V   +  + E+LV Q   FS+RP+ +P+   ++K  GI+    G  W+  RK +   +   G+  L++E K+++E   + +E+ K  + P     + +  V NIIC L   R F+Y + +F  ++ N      +  +N    + +I + W++   F   +     L ++EK +   L    +      D  NP   ++ YL L  ++E    S+  + +  +     D++ AG DTTT+ L WC L + L P+ Q +I  EI +   ++ A +        + +A + E  R   V+  ++ H   +    +GF +    +++ +  ++ +DP IW+ P +F P RF+D+   L K  +  I FGIGKR CMGE LA+ EL ++ +S++Q+F   L +++      I++G  GL  AP    II
Sbjct:   60 PPGPAPWPVVGNFGFVLLPRFLRRKSWPYRRARNGGMNASGQGVQLLLADLGRVYGNIFSFLIGHYLVVVLNDFHSVREALVQQAEVFSDRPR-VPLTSIMTKGKGIVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFRYVKEEMQKHGDAPFNPFPIVNNAVSNIICSLCFGRRFDYTNSEFKQML-NFMSRALEVCLNTQLLLVNICS-WLYYLPFGPFK----ELRQIEKDLTLFLKKIIKDHRESLDVENPQDFIDMYL-LHVEEEKKNNSNSGFDEDYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLHPNIQEKIHEEIARVIGADRAPSLTDKAQMPYTEATIMEVQRLSTVVPLSIPHMTSEKTVLQGFTIPKGTIILPNLWSVHRDPAIWEKPNDFYPDRFLDDQGQLIK-KETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFTFVLPKDS----KPILTGKYGLTLAPHPFNII 539          

Query:   87 YYQRQKD---PPGPIGWPVFGS-----TPERL---YWYLTGRE---YSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXX-XXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNIQVIGQDGNVNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFD--NPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEI-KANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAP 1505
            + +RQ+    PPGP   P+ G+      P  L   +W  +G +     Q    + M   YG ++S  + H   +V + +  + E+LV Q   FS+RP+ +P++  ++K+ GI+    G  WK  R+ +   +   G+  L++E ++++E   + + + K    P     + S  V NIIC L   + F+Y +++F  V+ +    G +  ++   F+ +I   W +   F   +     L ++E+ +   L     +     D  NP   ++ YL L  ++E        + +  +     D++ AG DTTT+ L WC L + L PD Q ++  EI +    + A +        + +A + E  R   V+  A+ H   +    +GF +    +++++  ++ +DP IW+ P++F P RF+D+   L K  +  I FGIGKR CMGE LA+ EL ++ +S++Q F   L + + +    +++G  GL  AP
Sbjct:   41 WLRRQRACGIPPGPKPRPLVGNFGHLLVPRFLRPQFWLGSGSQTDTVGQHVYLARMARVYGNIFSFFIGHRLVVVLSDFHSVREALVQQAEVFSDRPR-MPLISIMTKEKGIVFAHYGPIWKQQRRFSHSTLRHFGLGKLSLEPRIIEEFAYVKEAMQKHGEAPFSPFPIISNAVSNIICSLCFGQRFDYTNKEFKKVL-DFMSRGLEICLHSQLFLINICP-WFYYLPFGPFK----ELRQIERDISCFLKNIIREHQESLDASNPQDFIDMYL-LHMEEEQGASRRSSFDEDYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQKKVHEEIERVIGCDRAPSLTDKAQMPYTEATIMEVQRLSMVVPLAIPHMTSEKTVLQGFTIPKGTVVLINLWSVHRDPAIWEKPDDFCPHRFLDDQGQLLK-RETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQTFTFALPEGSEKP---VMTGRFGLTLAP 520          

Query:   84 HYYQRQKDPPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNIQVIGQDGNVNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFDN---PSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEIKANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAPLEHEII 1523
            H +QR +   GPIG PV GS P  LY       +   +  +EM+  YG + S  L     I+ + Y+ I  +LV +  QFS RP   P+   +++  G++   G  W  HR+ TL+++   G+     E ++  E+++L  ++   + +    +   +K ++N+I  L+  +   Y+D K  N + + + + Q G    L F    +  W+      + R Y+ +    EKW+        +  +  +D    PSC +E YL  Q+ ++++G     +   Q++R   D+Y AG +TT   L W  L     P++Q     EI A+     ++    +  H  +AFLDE  R   ++  +V H V + ++  G  + P  L++ +  ++  DP+++  P EF P RF+D     YK +++LI F +GKR+C+GE LAR EL I  ++++Q F  + T++     + I+ G +G++ AP +H ++
Sbjct:   19 HLFQRLRRR-GPIGLPVLGSLPYMLYRAFVEPGFRWYRFLNEMRAAYGDVISVVLGTQEFILISGYQQIKAALVGRADQFSQRPNQ-PLYQVMAQGRGLLLSEGALWLEHRRFTLRVLRDFGLGRSLSEQQIQTEAQELAAKLSDLSGQETDLNVHITKAIVNVIGSLVFAQRSGYEDPKLDNFLHHTKALTQAGLDTELMFFFPQLPAWLTALAPSTGR-YLQS----EKWIMDHCREKIQAIDRNYDESSEPSCFVEAYLQEQRLRQASGGVGS-FDNLQLVRTVLDLYLAGSETTATTLRWALLYCSFHPEYQEACHAEIAASIGLREVSMKDKRGLHKVQAFLDETQRIANLVPMSVEHRVSEAVELDGLPISPDSLVLPNLYSVHMDPELFPEPHEFKPDRFIDPETGTYKASEYLIPFSLGKRACLGETLARMELFIFFVTLLQKFRFEPTEDCRLRRDEILLGPDGVVRAPGDHSLV 494          

Query:   36 MFIGILCFLIALLFLYHYYQRQKDPPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNIQVIGQDG--NVNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFDN---PSCILEHYLVLQKQQESNGESS-DLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEIKANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAPLEHEII 1523
            + I ++  L+A L   H  +R K   GPIG P+ GS P  +Y  +T R++       EM++ YG + S  +     +V + Y  I  + V +   FS RP   P    V++  G++F  G  W+  R+  L+++   G+     E ++  E+++L + +     +        +K V+N+I  L+  +   Y+D K    +++ + + Q G   V ++FF +  I       +  S+    + + + E+WV        +  +  +D    P C +E YL  Q+ ++++GE     +   Q+IR   D+Y AG DTT   L W  L     P+ Q     EI     +  ++    +S H  +AFLDE  R   ++  +V H   K +DF G  + P  +++ +  ++  D +++  P EF+P RF+D     YKP+++LI F +GKRSC+GE LAR EL +  ++++Q F  +  ++       I+ G +G++ AP +H ++
Sbjct:    3 LVITVIVGLLAALLGRHLIRRLKRR-GPIGLPILGSLPYMMYRAVTDRQFRWYLFVDEMRKAYGEVISLVIGTQEFVVISGYNKIKAAFVDRADVFSQRPNH-PFYQIVAEGRGLLFSEGPLWQDQRRFALRVLRDFGLGRSLSEQQIQTEAQELARHLSDYNGQETDVKSHITKAVVNVIAGLVFAQRSGYEDPKLEEFLEHTKALTQAGLDTVLMVFFPQMPI-------SLTSLSPSSNRILQSERWVMDYCWDKIQDISRNYDESSEPICFVEAYLREQRMRQASGEGDVGSFDNRQLIRTVSDLYVAGSDTTATTLRWALLYCCFHPELQEACHTEISTVIGDREVSMKDKRSLHKVQAFLDETQRMANLVPMSVEHRAAKEVDFDGLPVSPDSIVLPNLYSVHMDQELFPEPHEFNPNRFLDLETGTYKPSEYLIPFSVGKRSCLGETLARMELFLFFVTLLQKFRFEPNEDCKLKREDILLGHDGIVRAPADHRLV 496          

Query:   36 MFIGILCFLIALLFLYHYYQRQKDPPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNIQVIGQDG--NVNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFDN---PSCILEHYLVLQKQQESNGESS-DLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEIKANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAPLEHEII 1523
            + I ++  L+A L   H  +R K   GPIG P+ GS P  +Y  +T R++       EM++ YG + S  +     +V + Y  I  S V +   FS RP   P    V++  G++F  G  W+  R+  L+++   G+     E ++  E+++L + +     +        +K V+N+I  L+      Y+D K    +++ + + Q G   V ++FF +  I       +  S+    + + + E+WV        +  +  +D    P C +E YL  Q+ ++++GE     +   Q+IR   D+Y AG DTT   L W  L     P+ Q     EI     +  ++    +S H  +AFLDE  R   ++  +V H   K +DF G  + P  +++ +  ++  DP+++  P EF+  RF+D     YKP+++LI F +GKRSC+GE LAR EL +  + ++Q F  +  ++       I+ G +G++ AP +H ++
Sbjct:    3 LVITVIVGLLAALLSRHLIRRLKRR-GPIGLPILGSLPYMMYRAVTDRQFRWYLFVDEMRKAYGEVISLVIGTQEFVVISGYNKIKASFVDRADMFSQRPNH-PFYQIVAEGRGLLFSEGPLWQDQRRFALRVLRDFGLGRSLSEQQIQTEAQELARHLSDYNGQETDVKSHITKAVVNVIAGLVFAERSGYEDPKLEEFLEHTKALTQAGLDTVLMVFFPQLPI-------SLTSLSPSSNRILQSERWVMDYCWDKIQDISRNYDKSSEPICFVEAYLREQRMRQASGEGDVGSFDNRQLIRTVSDLYVAGSDTTATTLRWALLYCCFHPELQEACHIEISTVIGDREVSMKDKRSLHKVQAFLDETQRMANLVPMSVEHRAAKEVDFDGLPVSPDSIVLPNLYSVHMDPELFPEPHEFNINRFLDLETGTYKPSEYLIPFSVGKRSCLGETLARMELFLFFVPLLQKFRFEPNEDCKLKREDILLGHDGIVRAPADHRLV 496          

Query:   36 MFIGILCFLIALLFLYHYYQRQKDPPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNIQVIGQDG--NVNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFDN---PSCILEHYLVLQKQQESNGESS-DLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEIKANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAPLEHEII 1523
            + I ++  L+A L   H  +R K   GPIG P+ GS P  +Y  +T R++       EM++ YG + S  +     +V + Y  I  + V +   FS RP   P    V++  G++F  G  W+  R+  L+++   G+     E ++  E+++L + +     +        +K V+N+I  L+      Y+D K    +++ + + Q G   V ++FF +  I       +  S+    + + + E+WV        +  +  +D    P C +E YL  Q+ ++++GE     +   Q+IR   D+Y AG DTT   L W  L     P+ Q     EI     +  ++    +S H  +AFLDE  R   ++  +V H   K +DF G  + P  +++ +  ++  DP+++  P EF+  RF+D     YKP+++LI F +GKRSC+GE LAR EL +  + ++Q F  +  ++       I+ G +G++ AP +H ++
Sbjct:    3 LVITVIVGLLAALLSRHLIRRLKRR-GPIGLPILGSLPYMMYRAVTDRQFRWYLFVDEMRKAYGEVISLVIGTQEFVVISGYNKIKAAFVDRADMFSQRPNH-PFYQIVAEGRGLLFSEGPLWQDQRRFALRVLRDFGLGRSLSEQQIQTEAQELARHLSDYNGQETDVKSHITKAVVNVIAGLVFAERSGYEDPKLEEFLEHTKALTQAGLDTVLMVFFPQLPI-------SLTSLSPSSNRILQSERWVMDYCWDKIQDISRNYDKSSEPICFVEAYLREQRMRQASGEGDVGSFDNRQLIRTVSDLYVAGSDTTATTLRWALLYCCFHPELQEACHIEISTVIGDREVSMKDKRSLHKVQAFLDETQRMANLVPMSVEHRAAKEVDFDGLPVSPDSIVLPNLYSVHMDPELFPEPHEFNINRFLDLETGTYKPSEYLIPFSVGKRSCLGETLARMELFLFFVPLLQKFRFEPNEDCKLKREDILLGHDGIVRAPADHRLV 496          

Query:   42 IGILCFLIALLFLYHYYQRQKDPPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNIQVIGQDGNVNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEK--WVESQLDATCEKFNPEF--DN-PSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEIKANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAPLEHEI 1520
            +  +  LI   + Y      K PPGP+G P FG  P  ++   T + +       E++ KYG L S  L     ++ + YE + E   +   +F+ RP       ++ K  GII   G  W+ HR+  L+++   G      E ++ +E+ +L++ +     + V +     K V N++ + + +    Y+D  F   +KN+  +     V L      I  F+ F     ++ +   N ++ +   W+E       E+    +  DN PS  +E YL   ++Q   G     ++  Q+++  +++Y AG+DTT++ LCW  +   L P+ Q R   EI A       +    K  H+ +AFLDEC R   ++  +V H      +F+G+ +    ++ ++   +  D   +  P+ FDP RF+      YKP+++L  FG+GKRSC+GE LAR E+ +  ++ +Q+F  +    T E    I+ GTEG I+  +EH +
Sbjct:   18 VAAVVGLIVCTYAYAKRALSKSPPGPVGIPGFGLLPLVMWRTATNKRHRFYLLMQEIQRKYGDLASFPLGTQELVLVSGYETMREMFAMNTDKFNGRPTT-NFHKFMFKDAGIIGSEGALWQEHRRFALRVLKDFGFGRNASELQIQEEAGQLVKFLSSKDGQLVDTRDFIGKAVANVVSRFIFSNFSSYEDSNFNEFLKNLGGVTNQNVVGL------ITAFYRFMPVETALALSPTNRKQFDAITWIEDLSQQKVEEIRSTYNVDNEPSNYVEAYL---QEQHRRGVDLGTFTDFQLVKTIWELYIAGVDTTSNTLCWSLIYAALNPELQDRCHAEIMAKIGKRQASLKDKKELHYCQAFLDECQRISTLVPMSVDHRAIGDTEFRGYKISSGSIIFVNLYGLHHDERYFPKPDMFDPDRFLTPDGQ-YKPSEYLNQFGVGKRSCLGEVLARMEVFLFFVTFMQHFRFEADSWTAEQREQILLGTEGGIHGTIEHRL 505          

Query:   96 RQKDPPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXX-XXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNIQVIGQDGNVNLLFF---MRSIINFWIFRETFKSVRIYM-DNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLV-LQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEI-KANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRA-VHAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAPLEHEII 1523
            R + PPGP      G+ P+ +              Y     KYG + S  L     IV  S ++  E+ V  G  FS RP  LP++ +++K  GI+    G  W+  R+  L  +   G+   ++E++V +E+  L++E+ K   KP          V NIIC ++    FEYDD++F  +++ I       N N+ F    +  I N   F +     +  +  NL+ L K++  +++   +  +PE  NP   ++ YLV ++KQQ SN +S+  + ++ ++R+  D++GAG +TT + L W  + +   PD Q R   EI +    +   + +      +  A + E  RY  ++    VH   +P   +G+H+     +M +   +  D D WK+P  F+P  F+DE     K N   + F +G R C+GE LAR EL I   S+IQ  +            L + G  G++ A L    I
Sbjct:   36 RSQSPPGPKPMLFVGNLPQFM---------KDKMGYIRSMPKYGEMCSMYLGRKPTIVLNSVQIAKEAFVQNGAVFSGRP-SLPLIRWINKGYGIVMATYGNSWRQQRRFALHTLRDFGLGKKSVEERVAEEARYLIKEMLKQEGKPFYPIHPIMNAVSNIICSIVFGDRFEYDDRRFAELLEII-------NENIRFSGSPVAQIFNLVPFIKHLPGPQQKIRQNLDSLNKFIFDEIEEHRKTLDPE--NPRDFIDSYLVEMKKQQGSNEDST--FHENNMVRSTIDLFGAGTETTANTLRWGLIYMMEHPDVQERCHEEIVRVLGFDCFPSMDDRAQLPYTLATVHEIQRYANIVPLGVVHQTTQPTKLRGYHIPAGTNIMSNLTAIMADKDHWKYPNTFNPENFLDEKGQFCK-NDSFLPFSLGPRVCLGETLARTELFIFFTSLIQQLKFSWPPGAPP---LNMDGIVGVVRANLPFNTI 494          

Query:   39 FIGILCFLIALLFLYHYYQRQKDPPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXX-XXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVI----KNIQVIGQDGNVNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEI-KANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRA-VHAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNT 1451
             +G L  L+ L  L     R + PPGP      G+ P+ +              +     KYG + S  L     I+  + ++  E+ V  GT FS RP  LP++ +V+K  GI+    G  W+  R+  L  +   G+   ++E++V +E+  L++E+ K   K           V NIIC ++    FEYDD++F  ++    +NI+  G    V  +F +  II +  F    + +     NL+ L K++  +++   +  +PE  N    ++ YLV   +QESN +S+  + +  ++R+  D++ AG +TT + L W  + +   PD Q R   EI +    +   + +      +  A + E  RY  ++    VH   +P   +G+H+     +M +   +  D D WK+P+ F+P  F+DE     K N   + F +G R C+GE LAR EL I   S+IQ  +    Q  
Sbjct:   17 LVGGLVSLVLLEILRLNSSRSRSPPGPKPLLFVGNMPQFI---------KDKMGFIRSMPKYGEISSLYLGRKPTIILNTMQVAKEAFVQNGTIFSGRP-SLPLVRWVNKGYGIVMATYGNSWRQQRRFALHTLRDFGLGKKSVEERVAEEAHFLIKEMLKQEGKAFYPIHPIMNSVSNIICSIVFGDRFEYDDRRFAKLLEIINENIRFSGSP--VAQIFNLVPIIKY--FPGPHQKI---WHNLQSLRKFMSEEVEKHRKSLDPE--NLRDFIDAYLVEMNKQESNEDST--FHEENMLRSTTDLFIAGTETTANTLRWGLIYMMEHPDVQERCHEEIVRVLGFDRFPSMDDRAQLPYTHATVHEIQRYANIVPLGVVHQTTQPTKLRGYHIPAGTNIMSNLTAILTDKDHWKYPDTFNPENFLDEKGQFCK-NDSFLPFSLGPRVCLGETLARTELFIFFTSLIQQLKFSWPQGA 472          

Query:   36 MFIGILCFLIALLFLYHYYQRQKDPPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXX-XXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVI----KNIQVIGQDGNVNLLFFMRSIINFWIFRETFKSVRIYM-DNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEI-KANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQ 1421
            + +G+L   +  +F  +   R + PPGP   P  G+ P+ +   +T         Y     KYG L S  L     IV  + ++  E+ V  G  FS RP  +P+  +++K  GI+       W+  R+  L  +   G+   T+E++V +E+  L++E+ K   KP          V NIIC ++    F+YDD++F  ++     N++++G          +  I N   F + F      + +N   L++++   ++   +  + E  N    ++ YLV   +QESN +S+  + K  ++R+  D++GAG +TT + L W  + +   PD Q R   EI +    +   + N      +  A + E  R   +    V H   +P   +GFH+     ++ +   +  D + WK+P+ F+P  F+DE     K N   +AF +G R C+GE LAR EL I   S++Q
Sbjct:   17 LVVGLLSLFVLEIFRMNS-SRNQSPPGPKPLPFLGNLPQFIKDPMT---------YIRSMPKYGELCSMYLGRNPTIVLNTMQIAKEAFVQNGAVFSGRPS-MPLTRWLNKGYGIVMAPYSNSWRQQRRFALHTLRDFGLGKKTVEERVAEEARYLIKEMLKEEGKPFYPSHPIMNAVSNIICSIIFGDRFDYDDKRFAKLLDILNDNVRLVGSP--------LAQIFNLLPFMKHFPGPHQKVWENDVALKEFIFEVVEEHRKTLDQE--NLRDFIDAYLVEMMKQESNEDST--FHKENMLRSITDLFGAGTETTANTLRWGLIYMMDNPDVQERCHEEIVRVLGFDRFPSTNDRSHLPYTYATVHEIQRNANIAPLGVMHTTTQPTQLQGFHIPAGTDIVPNLTAILNDQEHWKYPDMFNPENFLDEKGQFCK-NDSFLAFSLGPRVCLGETLARTELFIFFTSLLQ 462          

Query:   36 MFIGILCFLIALLFLYHYYQRQKDPPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXX-XXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVI----KNIQVIGQDGN--VNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEI-KANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAVHAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQN-TLENINLIISGTEGLIYAPLEHEII 1523
            +  G+L   +  +F  +  +RQ +PPGP   P  G+ P+             +  +     KYG L    L +   IV  S  ++ E+ V  G  F+ R   +PI+D+V+   GII    G  WK  R+  L  +   G+    +E++V +E++ L++E+     K           V NIIC ++    FEYDD++F  ++    +NIQ+ G      V ++ F+R       F    + V     N++ L++++   ++   +  +PE  NP   ++ YLV   +Q+SN +S+  +++  +I +  D++ AG DTT   L W  + +   PD Q R   EI +    + +   +      + +A + E  R   +I  A+H   +P     +H      +M +      D   WKHP+ F+P  F+DE     K +++ + + +G R C+GE LA+ EL I   S+IQ  +          N+N I+S    ++ +P  +  I
Sbjct:   17 LLAGVLSLFLLEIFRLNSSRRQ-NPPGPKPLPFVGNLPQL---------KKDAMAFVRSMAKYGDLSCLYLANKPVIVVNSLPMVKETFVQNGGAFAGR-SPVPILDFVTNGYGIIMAPYGISWKQQRRFALHTLRNFGLGKRNVEERVAEEAQYLIRELLTHEGKSFCPIHKIMNAVSNIICSIVFGDRFEYDDKRFSKLLEIINENIQLSGAPATRMVYVVPFIRH------FPGPHQKV---WQNVKSLKEFIREAVEEHRKTLHPE--NPRDFIDAYLVEMSKQQSNEDST--FNEENMIMSTSDLFLAGTDTTASTLKWGLIYMMDHPDVQERCHEEIVRVLGFDRSPCMDDRAKLPYTQATIHEIQRCADIIPMAIHETTQPTQLGEYHFPKGTKIMPNLAIFLADRKHWKHPDTFNPENFLDEKGQSCK-SEYFLPYSLGPRMCVGETLAKAELFIFFTSLIQRLKFSWPPGEPRPNMNGILS----IVRSPFPYNTI 492          

Query:  102 KDPPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVI----KNIQVIGQDGNVNLLFFMRSIINFWIFRETFKSVR-IYMDNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEI-KANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFE 1430
            + PPGP      G+ P+ +       +   +   S+M  KYG + S  L     IV  S ++  E+ V  G  FS RP  LP++ +++K   I    G  W+  R+  L  +   G+   ++E++V +E+  L++E+ K   KP          V NIIC ++    F+YDD+ F  ++    +NI++ G         F+  I N   F + F   +  +  NL+ L K++  +++   +  +PE  N    ++ YLV   +QE+N +S+  + ++ ++R+  D++GAG +TT + L W  + +   PD Q R   EI +    +   + +      +  A + E  RY  ++   V H   +P   +G+H+     +M +   +  D D WK P  F+P  F+DE     K N   + F +  R C+GE LAR EL I   S+IQ  +
Sbjct:   38 RSPPGPKPMLFVGNLPQFM-------KEKMAYIRSQMP-KYGEMCSMYLGRKPTIVLNSVQIAKEAFVQNGAVFSGRP-SLPLIRWINKGYIIGATYGHSWRQQRRFALHTLRDFGLGKKSVEERVAEEARYLIKEMLKQ-EKPFYPIHPIMNSVSNIICSIVFGDRFDYDDKYFAELLAILNENIRLAGS--------FIGQIFNLVPFIKHFPGPQQKFKQNLDSLNKFIFDEVEKHRKTLDPE--NLRDFIDAYLVEMNKQEANEDST--FHENNMVRSTIDLFGAGTETTANTLRWGLIYMMEYPDVQERCHEEIVRVLGFDRFPSMDDRAQLPYTLATVHEIQRYANIVPLGVIHETTQPTKLRGYHIPAGTNIMANLTAIMADKDHWKFPNTFNPENFLDEKGQFCK-NDSFLPFSL-PRVCLGETLARTELFIFFTSLIQQLK 463          

Query:   39 FIGILCFLIALLFLYHYYQRQKD-------PPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXX-XXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFIN----VIKNIQVIGQDGNVNLLFFMRSIINFWIFRETFKSVR-IYMDNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEI-KANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQ-RAVHAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFE 1430
             I +  F I  L L    Q  K        PPGP   P  G+    L+               E+ ++YG + S  +  I  +  + Y+ + E LV QG +F++RP + P    V+   GII    GKYW  HR+ TL  +   G+   +IE + +Q     L E FK            +  V NIIC ++  + +EY D++F +    V  N+Q+  Q G       + ++ N + F   F   + I   ++ + ++++   +       +P    P C+++ YL  Q ++E N  SS  +S+  +I    D++ AG +TT+  L W  L + + P+ Q +   EI K   S+         S  +  A + E  R+  ++   A HA    + F+ + +    ++M++ K++  D + WK P EF P  F+DE     KP+  L  F  G R C+GENLA+ EL +   S++Q+FE
Sbjct:   24 LISLAIFCIIFLVLRAILQEVKATKRPLDFPPGPKVIPFLGNV--SLF-------KKPDVALDEVTKQYGEVCSVMVGKISMVFVSGYQAVKEVLVHQGHEFADRP-NTPFNKKVNGGLGIIFAPYGKYWMQHRRFTLSTLRNFGLGKSSIE-QTIQAEVGFLIEAFKQKGSAFDPHYDLNSAVGNIICSMVKGKRYEYSDKQFQDFLHLVENNLQL--QSG------LLGTLCNIFPFLMDFPGPQQIIFKSMAKSKQFIRDIISERHATRDP--IKPMCLIDAYLS-QLEKEDNPNSS--FSEQSLIMLALDLFIAGAETTSTTLRWGLLYMMMHPEIQAQCHEEIDKIVGSDRLPCMEDRHSLPYLDAVIHEIQRFSNIVPFGAPHATTADVKFRQYLIPKGTIIMVNMKSVLSDENHWKTPYEFSPENFLDEDGKFVKPDAFL-PFSAGPRVCLGENLAKMELFLFFASLLQHFE 477          

Query:  111 PGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPK--DLPIMDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMN-------NLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYS--KPVMNIICQLMLNRSFEYDDQKFINVI----KNIQVIGQDGNVNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEIKAN-KSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRD-LLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIA----FGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNT 1451
            PGP+ WP+ G+  +   W     + ++      M ++YG ++   L  +  +V +  E I  +LV  G  F+ RP    L ++                WKAH++     +                +E+ V +E+E+LL        +P   D + S    V N++C L+  + + + D  F+ ++    +  Q+ G    V+   F+R + N  +      S R+    L  +E  ++    +  +    +      I +  + +  +QE       L S  +++    DI+GAG DT    L WC L L + PD Q +++ EI      +    F    +    +AFL E FR+   +   + H+  + +   G   +PRD  + ++   ++ DP +W  PE FDP RF+       + NK ++     FG+GKR C+G+ +AR EL ++L++++Q    ++   T
Sbjct:   59 PGPVRWPIVGNILQ--LWPDPHLKLTR------MCDRYGDVFRVHLGSVPVVVLSGLETIKRALVKNGDAFAGRPPFYSLSLVGN-GDTLTFTRAYDGCWKAHKRLARSALRNFCAAPARREGYACLLEECVCEEAERLLLACKGGGAQPGGFDPVPSITCAVANVMCALVFGKRYPHGDPTFLQIVGFNEEASQLSGAGNLVDFFPFLRHVPNAQLRALKVLSARL----LAFMEGHIKEHYSSYQKGHVRD------ITDALIAMCAEQEHALREVGL-SDERVVATALDIFGAGFDTIITGLTWCLLYLCIHPDVQHKLQREIDETIGRDRTPRFEDRANLRRVEAFLTEMFRHSAFVPFTIPHSTTQDVVLNGM-FIPRDTCVFVNLHQVNHDPTVWSDPERFDPDRFLSHDGK--EVNKEMVEKVQIFGLGKRRCLGDMVARQELFVVLVTLLQGLSFRVPPGT 504          

Query:   48 ILCFLIALLFLY--HYYQRQKD---PPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFIN----VIKNIQVIGQDGNVNLLFFMRSIINFW-----------IFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEI-KANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAPLEHEIIYI 1529
            +L  ++A+LFL+   ++ R++    PPGP G P+ G+      + L  +    S    ++ E YG ++S  L   R +V    E+I E+LV Q   F +RP+       +    G++   G  W+A R+ TL ++   GM   +IE+K+ +E+E L++ I     KP  +    +K   N+IC +     ++++++ F+     + +N+++ G D   + +F    ++ ++           +    F   RI   ++  ++      LDA  +K   +  NP                       +S   +I    +++ AG +TT+  L W  L++   P  Q +++ EI +   SN            +  A + E  RY  ++  A  HA       +G+ L     ++    +  ++  +W+ PE+F+P  F+D   + Y  N  +    +G R C+G+NLAR E+ +   +++Q F     Q    +    ++   G+++ P  +E+  I
Sbjct:   16 VLLRVVAVLFLWLGFWWLRREQRGFPPGPRGLPLVGN-----LFQLDLKALPAS--LDKLSETYGPIYSVSLGQTRVVVLVGNEIIKEALVTQAEMFIDRPEIPVFKKSLGNYEGLLLSHGWQWRARRRFTLMMLRNFGMGTKSIEEKIAEEAEFLVRAIENKQEKPFDAHSEINKSAANVICSITFGDRYDWNNKTFVKLMDIITENVELSGNDW--SQIFNSFPVLKYFPGPHQRINKNKVVLNAFIQARIEEHDMARIQGEPRDYLDAFIDKRIEDSMNPDTA--------------------FSDIALINTTANLFVAGSETTSATLKWGILLMLTYPKVQEQVQEEIDRVVGSNRRPACADRACMPYTNATVHEIQRYANILPMAFPHATTCDTKLRGYFLPKGTQVIALIHSALREKSLWEAPEQFNPGHFLDIDGNFYNRNDFMAFSAVGPRICLGKNLARMEVFLFFTALLQRFSF---QGQPGHPMPDLTPKSGIVWNPFRYEVCAI 499          

Query:  207 EMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNIQVIGQDGNVNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEI-KANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFE 1430
            E+ +KYG + +  L     ++ + YE + E LV +G +F++RP            G  +   G  WK  R+  L  +   G    TI DK+  E++ L+ E FK            +  + NIIC L+    ++YD+++F  +   ++ + Q     L+               ++ V      L+ L   + S+  AT ++ NP       +++ YL    +++ N  SS  ++   +I+   +++  G++TT++ L W  L + + PD Q R   EI +   S         +S  +  A + E  R+  V+   V HA  K + F  +       +M++  +   D   WK P +F+P  F+D+     + +  L  F  G R C+GE+LA+ E+ +   S++Q+FE
Sbjct:   65 ELAKKYGEVCTIMLGSTPVVLVSGYEAVKEVLVNRGHEFADRPITPIFTKLTQNIGIALAPYGDPWKQQRRFALSTLRNFGFGKATIADKISIEAKYLI-ETFKQETSAFDPHLNLNNALGNIICCLLNRNRYDYDNEQFQKLTHLLEYLVQLQAEPLVILCNVFPFLLKLPGPWQKVFHIHSKLQCLLNDIVSEHRATKDQHNPRD-----LIDSYLAQIDKEKDNPNSS--FTHQSLIQILIELFIGGLETTSNTLRWGLLFMMMNPDIQARCHGEIDRVVGSERPPCMTDRRSLPYLDAVIHEIQRFGNVLPLGVLHATSKDVQFNDYLFPKGTHVMVNLMSALHDDIHWKTPNKFNPDHFLDKDGQCIQSDAFL-PFSAGPRVCLGESLAKMEIFLFFTSLLQHFE 465          

Query:  207 EMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNIQVIGQDGNVNLLFFMRSIINFWI-FRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEI-KANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFE 1430
            E+ +KYG + +  L     ++ + Y+ + E LV +G +F++RP            G  +   G  WK  R   L  +   G    TI DK+  E+  L+ E FK          + +  V NIIC L+    ++Y++++F  +   ++ + Q      L  + ++  F I     ++ V      L+ L K + S+  AT ++ NP       +++ YL    +++ N   S  ++   +I    +++  G++TT++ LCW  L + + PD Q R   EI K   S         +S  +  A + E  R+  ++   V H   K + F  +       +M++  +   D   WK P +F+P  F+D+     K +  L  F  G   C GE+LA+ EL +   S++Q+FE
Sbjct:   61 ELAKKYGEVCTIMLGSTPVVLVSGYQAVKEVLVNRGHEFADRPITPLFTKLTHNIGIALAPYGDTWKQQRGFALSTLRNFGFGKATITDKISIEARYLI-ETFKQETSEFDPKFILNSAVGNIICSLLNGIRYDYNNEQFQKLTHLLEHLVQL-QAEPLVILCNVFPFLIKLPGPWQKVFHIHTKLQCLLKDIVSEHRATKDQHNPRD-----LIDSYLAHIDKEKDNPNRS--FTDQTLILLLIELFIGGMETTSNTLCWGLLFMMMNPDIQARCHEEIDKVVGSQRPPCMKDRRSLPYLDAVIHEIQRFGNILPFGVLHPTSKDVQFNEYVFPKGTHVMVNLMSAFYDDIHWKTPHKFNPDNFLDKDGQCIKSDAFL-PFPAGPCVCFGESLAKMELFLFFTSLLQHFE 461          

Query:  834 PSCILEHYL-VLQKQQESNGESSDLYSKH----QIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNE---IKANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAVHAVEKPIDFKGFHLVPRD-LLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIIL 1406
            P C+++ +  ++   + SN + S +Y +     +I    F    A  D ++ + CW   ++  +PD   +IR E   ++ N  ++ +N +  +   +    + E  RY P +    + V+K       +  P+  +L+        DP+++++P+EF P R+++ ++   +  K+ + FG G   C+G+         +L
Sbjct:  292 PVCVMDAWCKLMHDAKNSNDDDSRIYHREFTNKEISEAVFTFLFASQDASSSLACWLFQIVADRPDVLAKIREEQLAVRNNDMSTELNLDLIEKMKYTNMVIKETLRYRPPVLMVPYVVKKNFPVSPNYTAPKGAMLIPTLYPALHDPEVYENPDEFIPERWVEGSK-ASEAKKNWLVFGCGPHVCLGQTYVMITFAALL 490          

Query:  198 CYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRP-------------KDLPIMDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIK---NIQVIGQDGNV--NLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPE--FDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEIKANKSNSAM-NFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKP-NKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFE 1430
             ++E+++ YG ++   L H   IV  S + I E+LV Q   F+ RP               L +MDY              WK  RK     +   G N L  +D +  E  +L   +  SA KP    +     V N+IC  +    ++ DD +F+ V +    +  IG  GN+  N+   + SI+ F   +     ++I  +  E LE+  +  +    + F+PE   D    +L+       +QE       L     I+     ++ AG +TT+  L W  + L   PD Q R+  EI       A    +  K     +AF  E  R   +   A+ H   +    +GF +     +  +  ++  DP +WK P  F+  RF+DE      P     + FG G R C+GE LAR EL + L  ++Q FE
Sbjct:   50 SFTELEKTYGKVYRLYLGHKLAIVL-SGDAIKEALVRQPRNFAGRPVLNPQLKSALNRGPGLTVMDYGET-----------WKLFRKLGHSTIKVYGENRL--QDVIKDEVLELCNRLESSAGKPFDITQQSGIAVTNVICTKLFGTRYQIDDPEFLRVYEIHDKLSRIGFGGNLVTNIFPSLASILPFSEKQRDL--IQIGQERYEILERKYQEHV----KTFDPENIRDYTDALLKAKQ--DAEQEDKSSKEHLQESTIIMAGLATLFIAGSETTSTTLGWAVIYLLHNPDVQERLHKEIDDVIGRDAFPQLSKRKELPVLEAFTAETLRLANLAPLAIPHKARERSTLQGFEIPEGTTVFANLWSLHHDPTVWKDPFTFNLDRFLDEEGKFKAPVGGTFLPFGAGPRVCLGEVLARSELFLFLSRMLQRFE 461          

Query:   36 MFIGILCFLIALLFLYHY---YQRQKDPPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTI------EDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFI-------NVIKNIQVIGQDGNVNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFD--NPSCILEH--YLVLQKQQESNGESSD---LYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEI-KANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMD-ETRHLYKPNKHLIAFGIGKRSCMGENLARCE 1391
            M I     L  +L +YH+   Y+    PPGP  WP+ G+ P+       G++  +S     +   YG ++   L H   +V      I E+L +Q  +F  RP        VS    +       ++ + +  +K+  K+G   L +      +  ++QE+E+L + I  S+++     K +   +MNIIC  +    ++ ++++F+       N+ +   V GQ   V++  F+R+I+  +              + +EL++  +        K+    D  + S I ++   L+L KQ+     ++D   L +K+ I+     ++ AG +TT   LCW  L L   P  Q +I   + K N           K     +AF+ E  R   ++   V H        +G+ +     ++ +  ++  +  +W++PE+F+P RF+D E    +    +L+ FG G R CMGENLAR E
Sbjct:    1 MIIESALALFLILTIYHFFFEYKHNNLPPGPHAWPLIGNIPQ------IGKQLHRS--LHSLSLIYGEVYRLYLGHTLVVVLTG-RAIKEALALQPVEFGGRPWT------VSFDLALRGERPLVFEDYGRH-VKLHRKMGHRALKVYSQKKYQQVIIQEAEELCKRIADSSDRIFDVKKEFGLCIMNIICTKIFGSRYQVNNKEFLEILNIHDNLFRLTTVTGQS-LVDIFPFLRNILPIY-------------GHTKELQETHDEWQKILWRKYKQHLDSFDVSNIRDYTDALLLAKQEAGVENTTDQKYLENKY-IVSAISTVFIAGSETTATSLCWAILYLIHFPKIQDQIYASVGKLNLQERQSFVEMRKMCPILEAFIAEVLRIITLLPLGVPHKTLCETILRGYTIPKGTTVLANLWSLHHNVSLWENPEDFNPERFLDKEGNFSHSMTDNLLPFGAGPRICMGENLARTE 447          

Query:   48 ILCFLIALLFLYHYYQR-QKDPPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNIQVIGQDGNVNLLFFMRSIINFWIFRETFKSVRIYMDNLE--ELEKWVESQLDATCEKF--NPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEIKANKSNSAM-NFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMM-DFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFE 1430
            +   LI+L  +Y +Y R ++ PPGP  WP+ G+        L  R+ +  K ++ +  KYG ++ R     + +V  + + IY+SL  Q + F+ RP   P +D+       +   G  WK ++K     +   G + L   + +  E +++ + +     +PV   K +     N+IC  +    ++  D +F+ + +    I +     ++   RS+ + + F      V I  ++ E  EL + ++ +      K+  + +   P  I ++  +L   + S   S  L     I       + AG +TT   L W  + L    D Q RI NE+        +   +  K     +AF  E  R   +    + H   +    +G H +P+   ++ +  ++  D   WK P +FD  RF+++       N   + F  G R C+GE LAR EL + L  ++Q F+
Sbjct:    6 VPALLISLALIYIFYSRKERLPPGPAPWPIIGNLD------LLIRKEALYKTFTNLSHKYGGVF-RLYLGSKPVVVLNGKAIYDSLARQPSVFAGRPTLPPSLDFGMDPDYGVLDYGPLWKFYKKLGHSAVRVHGTDRLN--EAIRVEVDEVCRRLDSLDGQPVDISKEFGIATTNVICARLFGSRYDVHDPEFLRIYEIHNKISR-----VVMSSRSLSDVFPFL-----VNILPESKERRELRELLQERYTIIWRKYKEHEQTFTPGVIRDYTDLLIDAKLSEKNSHKLTENGIISTGLASQFLAGSETTASTLSWSVVYLLNDSDVQERIHNELDDVIGKGQLPQLSHKKKLPVLEAFTAETLRLSCIGPLGMPHKTTRDTFLRG-HAIPKGTTVVPNLWSLHHDSTEWKDPFKFDINRFLEDGVFRAPANDAYLPFSAGPRVCLGEELARSELFLFLARLLQKFD 454          

Query:   45 GILCFLIALLFLYHYYQR----------QKDPPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQ-FSNRPKDLPIMDYV--SXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNI-----QVIGQDGNVNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEIKANKSNSAM-NFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNK--HLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAPLEHEII 1523
             +  F ++LL L+ +  +           + PPGP G+PV G+      + L  + +     + EM   YG ++S  L   R +V  +   + E+L  + ++ F+ RPK L  M+       G I     + WK  RK  +  +HK       +E  + + +  L+Q +   A  P            ++I  ++     E  D   +  I        + +G    V+ + +M    NF I +   + V++  D    L+   E    +   +     D    + E +  +    +  GE +DL     +++   D+ GAG DT++  L W        P  Q RI +EI        +   +  K   +  A L E  R   +   AV H+  + +DF+G+ +    ++  +  ++ ++ + W++P+ FDP RF+DE   L  PN     + FG G R C G  LA  EL   + +I+Q F       T ++  + ++G  GL   P ++ +I
Sbjct:   23 ALALFFVSLLALFVFAAKIKIRTPRFLVSRLPPGPWGFPVIGAA-----FRLGPKSHLD---FLEMSRNYGQVFSMYLGS-RLVVVLNGMALQEALTGKLSRVFAGRPK-LYTMERCRNGGDGLINAPYCRKWKLMRKTAITAIHKYIATQDVLESILGKVAHGLVQRLDACAETPHNVMPELKFATASVILGILFG---ENHDASHVESILGTSDDFRKCVGCGLAVDFMPWME---NFPIPKVN-RMVKLTSDMNAVLKNLYEENKTSYSGRIRNLADAVIKVSEEHSQIDDDSDPKGEMADL----DVVQTIVDLVGAGFDTSSLTLYWAIAYFVKYPQVQRRIHHEIDTVIGRDRIPTLDDVKHLPYTHACLYELLRVTCLAPTAVPHSTLEEVDFRGYTIPKDTVIFANIWSLLRNEEYWQNPDVFDPMRFLDEEGRLLNPNSWPTFLPFGAGIRKCTGRELAIAELMFFITAIMQKFRFSEEGLTADHPPIDLTGEAGLTLKPADYHVI 516          

Query:   48 ILCFLIALLFLYHYYQRQKDPPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYG-ALWSRKLFHIREIVFASYELIYESLVIQ-GTQFSNRPKDLPIMDYVSXX--XXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNIQVIGQDGNV-NLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFN-PEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEIKANKSNSAMNFNT------TKSFHFFKAFLDECFRYFPVIQRAVHAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKL 1439
            IL  + +L  L+ + Q +  PPGP  +P  G+ P+       G    +S   + + ++YG  ++  +L   R ++  + +L  + L+ + G   ++R     ++D +S+     I       WK  R+     +   G     +E  ++QE + L      S   PV +    +  VMN+IC L+  + +  DD +F +++   + + +  +  N L +M      W+     + V+   + +   ++ ++ ++    E +   E  + +  L   L   KQ+++N  S  L ++  ++    D++ AG +TTT  L W  L +   P+ Q RI  E+     +  ++F         KS  + +A + E  R  PV         K ++  G+ +     + ++   +  D   W  P +F P RF++ T         ++ FG G R C+GE+LA+ EL + +  ++  F++ L
Sbjct:    9 ILIAIASLTSLHIWRQDKNAPPGPPLYPFVGNFPQ------IGPVLHKS--LTSLGKQYGRGVFQVQLLGKRFVIIDNIKLARQVLLKKNGRDVADRTSAY-VIDAISRNGCSVIFGKYSPTWKLQRRVVHSALRMYGSGVRILEALILQEVDNLCDIFANSQGAPVDTKLPLTLSVMNVICALVFGKRYGLDDAEFTDIVATTESMAKLASPENPLIYMP-----WLRFFPLQVVKKMKETVTARDRLIQRKITEHRETYKEGEIRDLTDALLKSLEDAKQEDNNAMS--LLTEDHLLIAINDVFMAGFETTTTALRWIFLYVAAYPEVQARIHQEL-----DDVISFGRDPLIADRKSLPYLEATILEVLRISPVFPLIRRKARKQLNIGGYCIPEETFVYVNLWAIHHDEAEWVDPYKFRPSRFLEGTNS--ASAYSMLPFGAGVRVCVGESLAKMELFLFVSRLLHRFKLNL 461          

Query:   36 MFIGI----LCFLIALLFLYHYYQRQKDPPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNIQVIGQDGNVNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEI-KANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFE 1430
            MF+ I    LCF   +LF +  ++ +  PPGP+  PV G+    L+  L          + +MKE YG ++S  +     +V    + + E+++I+ T FS RP+D+ + D   +KG I+   G  W+ HR+  L  +   G+  +++E+++ +E +  + ++ ++  K +    ++     NIIC+++ N  ++Y+D K   +++    + Q  N        +      F   F      M+N   L K + ++      K +     P   ++ YL    + E N +    +S+ Q++R  FD+Y AG DTT++ +    L L + P  Q + + EI +  +    ++F       + +A + E  R+  ++  +V H   K  +  G+ +    L++ +  ++ ++   WK P EF+P  F+++     KP +  + F  G R C+GE LAR EL II++++++ F+
Sbjct:    1 MFVSIFLLWLCFFF-ILFQFKLWRPKNFPPGPLSLPVLGNL---LHLNLKNPLVD----FEKMKESYGNVYSFFIGSRPAVVVNGLQAMKEAIMIKATDFSGRPQDMFVSDLTQRKGVILVDYGSVWRDHRRFALMTLRNFGLGKISMEERIHEEIQFTISKLEENIGKTLSPKFMFHNAASNIICKVLFNTRYDYEDGKISEIVQGFVEMLQIANGPWAMMYDAFPWIRSFPLPFNKAFRNMENFLNLAKRLVNE-----HKMSRVAGEPRDFVDSYL---DELEKNKKD---FSEQQLLRMTFDLYIAGTDTTSNTMLAGFLYLMVYPHIQEKCQREIDQMLERKDRVSFEDRHKMPYMQAVIHEVQRFANIVPLSVFHCTTKDSELSGYTIPKGTLIIQNMVSVLREEGQWKFPHEFNPENFLNDQGEFIKP-EAFMPFSAGPRMCLGEGLARMELFIIMVTLLRKFK 451          

Query:   39 FIGILCFLIALL---FLYHYYQRQKDPPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVI----KNIQVIGQDGNVNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEIKANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQN-TLENINLIISGTEGLIYAPLEHEIIYIP 1532
             +GIL  L+      F+++  Q  ++PPGP   P+ G+    L      R Y   K   E  + YG +++      + +V A Y+ +  +LV    +F  R    PI+  ++K  G+++  G  W+  R+  L  +   GM     EDK+ +E + LL+   K       + K  +  V NIIC ++    FEYDD KF +++    +NIQ+ G              +  W+F+    S R   +      K  +S      E  NP+       ++ +LV  +  E +G ++  ++   ++     ++ AG +TT+  L W  L++   P  Q ++++E++    +  +  +  K+  F  A + E  R   ++  A+ H   K + F+G+ +     +     ++  D + W+ P  F P  F+D+     K  +  I F  G+R C+GE+LAR EL +   +++QNF        + E ++L   G  G+   P+ H++  +P
Sbjct:   15 LVGILAVLVLYFISQFIFNSEQHGQEPPGPRPLPIIGN----LMQIDLKRPY---KTLEEFSKTYGPVFTVFFGGEKVVVLAGYKTVKNALVNHDEEFGERAIP-PIIQELNKGLGVLWSNGDIWRDIRRFALTNLRDFGMGKKACEDKITEECQYLLEVFKKFKGNAFDTTKPLNYAVSNIICSMVYGSRFEYDDPKFTSMVDRTNRNIQLSGSPT------LQAYNMVPWLFKWV-ASRREVHECAAANRKQNQSIFSHLKETLNPQMCR--GFVDAFLVKGQTLEKSGVTNSAFNDENLLMTVIHLFAAGTETTSTTLRWGLLLMAKYPKIQDQVQDELRRVIGDRMVQVSDRKNLPFTDAVIHEIQRLASIVPTALPHKTSKDVTFQGYFIKKGTTVFPLLTSVLHDANEWEKPHTFYPAHFLDKDGKFVK-REAFIPFSAGRRICLGESLARMELFMFFTTLLQNFCFTPPPGVSKEELSLTPCG--GITVGPVPHKLCAVP 501          

Query:  108 PPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRP-KDLPIMDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNI-QVIGQDGNV-NLLF-----FMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLV-LQKQQESNGESSDLYSKHQIIRNC-FDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEI-KANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQ-RAVHAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAPLEHEI 1520
            PPGP+G P  G+       +LT         +S+M E YG ++S +L     +  + Y+++ E+LV Q   F +RP  ++    Y     G+ F  G+ WK  R+  L  +   G+   T+E  + +E   L Q+I      P     L++  V NIICQL++ + F+YDD  F  ++K I + +  +G++  +L+      M+ +       + F++ +I  D L +  K  +  LD          +NP   ++ +++ ++K Q     +SDL      +  C  D++ AG +TT+  L W  + L   PD Q +++ EI +    N   +     +  +  A + E  R   ++    +    K     G+ +     LM    ++  D   W+ P+ F+P  F+D      K  +  + F  GKR C+GE LAR EL + L+ ++Q F   +     E + L   G  G    P  +++
Sbjct:   38 PPGPLGLPFVGN-------FLTIDGKHPHIYFSKMAESYGNVFSVRLGSQATVFVSGYKMVKEALVTQAENFVDRPFSEIGGRFYEGNSNGLFFSNGEKWKKQRRFALSTLRTFGLGKNTMEQSICEEIRHLQQQIENEKGGPFSPAGLFNNAVSNIICQLVMGKRFDYDDNNFQVMMKYISEAVQLEGSIWGILYESFPGLMKHLPG--SHNKIFRNYKIVQDFLAQEIKIHKQDLDP---------NNPRDYIDSFIIEMEKHQ-----NSDLGFNDANLAFCSLDLFVAGTETTSTTLMWALIYLIKHPDVQVKVQQEIDRVIGQNRLPSMADRPNLPYTDAVVHEIQRIGNIVPLNGLRVAAKDTTLGGYFIPKGTALMPMLTSVLFDKTEWETPDTFNPEHFLDADGKFVK-KEAFLPFSAGKRVCLGEGLARMELFLFLVGLLQKFSFSVP----EGVELSTEGITGTTRVPHPYKV 492          

Query:   87 YYQRQKD-----PPGPIGWPVFGS-----TPERLYWYLTGREYSQS----KCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXX-XXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFK----SANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNIQ-----VIGQDGNVNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFD--NPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEIKANKSNSAMNFNTTK-SFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAPLEHEIIYIP 1532
            +YQ+Q+      PPGP  WPV G+      P  +   + G+  S +    +   +    +G + S  +     +V   + LI ++L+ Q   FS+RP D+P++  ++K+ GI+    G  W+  RK     +   G+  L++E  + +    +  E+ +      +  V    L    V N+IC L+L + F + D +F  +I+ ++      I     +  +F +   + F +F+E           L ++E+ + + L     K     D  NP  + + YL+    Q++ G     ++   +     D++ AG DTTT+ + W  L + L PD Q + + EI        +   T K S  F +A + E  R   V+  A+ H   +   F+G+ +    ++  +  ++ +DP +W+  + F+P RF+D   +L +  ++ I FGIG+R CMGE LA+ EL + + +++Q F+ +  +    N    +    GL  AP    +   P
Sbjct:   34 FYQKQRTIYKNIPPGPKPWPVVGNFGNFFVPPSVRTKIAGQPNSTNAIEIEALRQQATVFGNIHSLFIGGQLIVVLHGFHLIRDALLNQPEVFSDRP-DIPLVTILTKRKGIVFAPYGPVWRKQRKFCHTTLRSFGLGKLSLEPCIQRGLAGVKAELLRLNEERGSAGVDPATLIGNSVSNVICSLILGQCFHHHDVEFRTMIRLMEHGLKICINSPAVLINIFPLLYYLPFGVFKE-----------LRQVERDITAFLKRIIAKHRDTLDPDNPRDLTDMYLIEMLTQQAAGVEDSSFTDDYLFYVIGDLFIAGTDTTTNSILWFLLYMILHPDVQDKAQAEIDGVVGKHRVPSVTDKGSLPFTEATIMEVQRLHSVVPLAIPHMTSETTVFRGYTIPKGTVIFPNLWSVHRDPTLWEDADSFNPSRFLDNEGNLLR-KEYFIPFGIGRRVCMGEQLAKMELFLTVTTLLQAFKFRHPEG---NPPPTVKERFGLTMAPCPFSVCVTP 527          

Query:   33 FMFIGILCFLIALLFLYHYYQRQKD-PPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNIQVIGQDGNVNLLFFMRSIINF----WIFRETFKSVRIYMDNLEEL-EKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEI-KANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAV-HAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLE 1457
            F+ + +L   I +LFL    +R K+ PPGP   P+ G+    L+  L     +  K +  ++  YG ++S  L     ++   ++ + E++VI+ T F+ RP+DL + D   +KG I+   G+ W+ HR+  L  +   G+   ++E+++ +E +  ++ +  +  K      ++     NIICQ++  + FEYDD+    +++      +  N        SI         FRE FK+  I +D    L  +  E+++      F        C L+       + E  G+ S  +S+ Q+I    D++ AG DTT++ L      L   P  Q + + EI +  +    + F    +  + +A + E  R    +  +V H+  K  +  G+ +    +++ +  ++ ++   WK P +F+P  F++E     KP +  + F  G R C+GE LAR EL II++++++ F+    ++  E
Sbjct:    2 FVSLILLWLCICILFLQLKPRRPKNFPPGPPVLPMLGNL---LHLSLD----NPLKDFDRLRNSYGNVYSLFLGPKPAVIINGFKAMKEAMVIKATDFAGRPQDLFVNDVSKRKGVILADYGESWRDHRRFALMTLRNFGLGKKSMEERISEEIQHTIKTLENNIGKLFSPQIMFHNAASNIICQVLFGKRFEYDDEIIKTIVQCFTRNSKIANGPWAMIYDSIPLIRKLPLPFREAFKNAEICVDVGTHLVNEHKETRIPGKPRDFV------DCYLD-------EMEKRGDDSS-FSEDQLIIYALDLHFAGTDTTSNTLLTGFFYLINYPHIQDKCQQEIDRVLEEKQQVTFEDRHNMPYMQAVIHEVQRIANTVPLSVFHSTTKETELMGYTIPKGTMIIQNMGSVLREDGQWKFPHDFNPENFLNEKGEFVKP-EAFMPFSAGPRMCLGEGLARMELFIIMVTLLRKFKFTWPEDAGE 462          

Query:   36 MFIGILCFLIALLFLYHYYQRQKDPPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNIQVIGQDGNVNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEIKANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAVHAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAPLEHEIIYIPI 1535
            MFI +LCFLI LLFLYHYYQRQKDPPGPIGWPVFGSTPERLYWYLTGR+YSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSKKGGIIFIGGKYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNIQVIGQDGNVNLLFFMRSIINFWIFRETFKSVRIYMDNLEELE+WVESQLDAT EKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEIKANKSNS MNFNTTKSFHFFKAFLDECFRYFPVIQRAVHAVEKPIDFKGFHLVPRDLLMMDFKT+SKDPDIWK PEEFDPFRFMDETRHLY PNKHLIAFGIGKRSCMGENLARCELTIILLSIIQ FEIKLTQNTLENINLIISGTEGLIYAPLEHEIIYIPI
Sbjct:    1 MFIEVLCFLIVLLFLYHYYQRQKDPPGPIGWPVFGSTPERLYWYLTGRKYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSKKGGIIFIGGKYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNIQVIGQDGNVNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEEWVESQLDATSEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEIKANKSNSPMNFNTTKSFHFFKAFLDECFRYFPVIQRAVHAVEKPIDFKGFHLVPRDLLMMDFKTLSKDPDIWKDPEEFDPFRFMDETRHLYNPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQTFEIKLTQNTLENINLIISGTEGLIYAPLEHEIIYIPI 500          

Query:   36 MFIGILCFLIALLFLYHYYQRQKDPPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNIQVIGQDGNVNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEIKANKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAVHAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAPLEHEIIYIPI 1535
            MFI +LCFLI LLFLYHYYQRQKDPPGPIGWPVFGSTPERLYWYLTGR+YSQSKCYSEMKEKYGALWSRKLFHI+EIVFASYELIYESLVI GTQFSNRPKDLPI+DYVSKKGGIIFIGGKYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPV+SDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNIQVIGQDGNV+ LF+MRSIINFWIFRETFKSVRI+MDNLEELE+WVESQLDAT EKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIY AGIDTTTHMLCWCTLMLGLKPDFQTRIRNEIKANKSNS MNFNTTKSFHFFKAFLDECFRYFPVI R  HAVEKPIDFKGFHLVPRDLLMMDFK MSKDPDIWK PEEFDPFRFMDETRHL+KPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAPLEHEIIYIPI
Sbjct:    1 MFIEVLCFLIVLLFLYHYYQRQKDPPGPIGWPVFGSTPERLYWYLTGRKYSQSKCYSEMKEKYGALWSRKLFHIKEIVFASYELIYESLVIHGTQFSNRPKDLPILDYVSKKGGIIFIGGKYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVESDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNIQVIGQDGNVHFLFYMRSIINFWIFRETFKSVRIFMDNLEELEEWVESQLDATSEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYSAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEIKANKSNSPMNFNTTKSFHFFKAFLDECFRYFPVIPRIAHAVEKPIDFKGFHLVPRDLLMMDFKAMSKDPDIWKDPEEFDPFRFMDETRHLHKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAPLEHEIIYIPI 500          

Query:   69 LLFLYHYYQRQKDPPGPIGWPVFGSTPERLYWYLTGR---EYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNIQVIGQDGNVNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEIKANKSNS-AMNFNTTKSFHFFKAFLDECFRYFPVIQRAVHAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAPLEHEIIY 1526
            LLFL H+Y+R+  PPGP+G+P+FG  P  +   +  +     S+ + + +M++KYG +WS +    R I  AS+++++E+ V  G  FS   ++  +M+    + GI+F  G  WK +R   +K +   GM   T+E  + ++++ L++EI + +   +   K++ K + NII  +  N     +D KF   +  +  I      +++F   S     + R  F  V  Y++ +    + V  +  +  + FN   D   C+ ++    +   E   + S       +I+   D+  AG +TT ++L +C L+LG  P+ Q  +RNE++    +S  +  +         +F+DE  R+  ++ ++ H V K   F+GF   P D++  D+  +  D + + +P++FDP+RF+DETR  Y P+K+LI FG+G+R+C+GENL+  E+ + L  I+  F I L   T+E+   I+ G  G+I++ L HE+I+
Sbjct:   13 LLFLRHFYKRKSHPPGPLGFPIFGIFPYSITQIIFSKFMTNVSECEYFKQMRQKYGNIWSIETVGQRTITLASFDIVHEAFVENGMLFSGCAQN-SLMELFGNRHGILFADGIIWKRNRHLAMKGLRYFGMGTSTMEKLICEQADCLIKEIKQKSGIQIDPSKIFVKNISNIINIVNFNEPNNENDPKFEKYVSCLDKISNSHIKHIIFIWPSFFLSKLGRFLFPKVEEYVNAIYNNRRLVADKCMSRLKVFNQSSD-LKCMFDYIWRNEDFIEDLNDQSYDVKLFNVIQIMTDLQNAGTETTYNLLRFCCLLLGRYPEVQDDLRNELQNLVEDSIQITLSLKNKCPKLLSFIDEVHRFCNLVPKSDHRVMKKCFFRGFDFYPSDMVFADYNAIMFDENHFDNPQKFDPYRFLDETRTEYTPSKYLIPFGMGRRTCIGENLSNMEIFLFLSRILYEFHISLLNETVEHFTEILKGETGIIHSCLNHELIF 500          

Query:   69 LLFLYHYYQRQKDPPGPIGWPVFGSTPERLYWYLTGR---EYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNIQVIGQDGNVNLLFFMRSIINFWIFRETFKSVRIYMDNLEELEKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEIKANKSNSA-MNFNTTKSFHFFKAFLDECFRYFPVIQRAVHAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMDETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAPLEHEIIY 1526
            LLFL H+Y+R+  PPGP+G+P+FG  P  +   +  +     S+ + + +M++KYG++WS +    R I  AS+++++E+ V  G  FS   ++  +++    K GI+F+ G  WK +R   +K +  +GM    +E    ++++ L++EI + +   +   K + K + NII  +  N     +D KF   +  ++        +++F   S     + R  F  V  Y++ +    + V  +  +  + FN   D   C+ ++    +   E   + S       +I+   D+  AG +TT ++L +C L+LG  P+ Q  +RNE++    +S  +  N         +F+ E  R+  ++ +  H V K   F+GF     D++  DF ++  D + + +P++FDP+RF+DETR  Y P++HLI FGIG+R+C+GE+LA  E+  +L  II  F+I L+  T+E+   I  G  G++   L HE+++
Sbjct:   13 LLFLRHFYKRKSHPPGPLGFPIFGIFPYSITQIIFSKFMTNVSECEYFKQMRQKYGSIWSIETVGQRIITLASFDIVHEAFVENGMLFSGCAQN-SLVELYGGKRGILFVDGAIWKQNRHLAIKALTTMGMGTSALEKLNCEQADCLIKEIKQKSGIQIDPRKEFVKAIANIINIVNFNEPNNENDPKFEKYMLCLEKFANSHIKHIIFIWPSFFLSKLGRFLFPKVEEYVNAIYNNRRLVADKCMSRLKVFNQSSD-LKCVFDYIWKNEDFIEDLNDQSFNVKIFNVIQIMTDLQNAGTETTYNLLRFCCLLLGRYPEVQDDLRNELQNLVEDSTQITLNLKNKCPKLLSFIGEVHRFCNLVPKVGHRVMKKFIFRGFEFDTSDMVFADFNSIMFDENHFDNPQKFDPYRFLDETRTKYIPSQHLIGFGIGRRTCIGESLANMEIFFLLSRIIFEFQISLSNETVEHFAKIFEGEIGIMRTSLYHELVF 500          

Query:  102 KDPPGPIGWPVFGSTPERLYWYLTGREYSQSKCYSEMKEKYGALWSRKLFHIREIVFASYELIYESLVIQGTQFSNRPKDLPIMDYVSXXXXXXXXXXXYWKAHRKDTLKIMHKLGMNNLTIEDKVVQESEKLLQEIFKSANKPVKSDKLYSKPVMNIICQLMLNRSFEYDDQKFINVIKNIQVIGQDGNVNLLFFMRSIINFWIFRETFKSV---RIYMDNLEEL--EKWVESQLDATCEKFNPEFDNPSCILEHYLVLQKQQESNGESSDLYSKHQIIRNCFDIYGAGIDTTTHMLCWCTLMLGLKPDFQTRIRNEIKA---NKSNSAMNFNTTKSFHFFKAFLDECFRYFPVIQRAVHAVEKPIDFKGFHLVPRDLLMMDFKTMSKDPDIWKHPEEFDPFRFMD----ETRHLYKPNKHLIAFGIGKRSCMGENLARCELTIILLSIIQNFEIKLTQNTLENINLIISGTEGLIYAPLEHEI 1520
            KDPPGPIG P  G  P  L+  L   + +++K + EM + YG +WS ++ + R +V  + EL  E+    G   S RP    +  YVSK+ G++   G+ W  +RK T K +H++       ED V+ E+ KLL          +++  L+    + II +++ N   ++DD+K    IKN+Q+I    N+     +  + N  + +    SV   +  MDN   +  E W ES+    CE    E    S I E YL   +  +   E     +    IRN  DI GAG DT    L WC L+L  +   Q ++R+EI      KS    +++      +  +F++E  RYF +I R VH   K + F G+ L+  D+++ D  T + + DIW + ++F   RF++    + +HL    ++   FG GKR+C+GE+LAR E+ + L+++I +++I+LT  +  N   I++G  GL++AP  H +
Sbjct:   24 KDPPGPIGIPFIGIFPVVLFKKLFRIKSNENKFFMEMHKIYGNIWSFRIINQRYVVLGAPELQTEAFKHSGMTLSGRPLT-ELYKYVSKRRGVLSSDGQIWVLYRKLTTKALHEISHKTRGFED-VITENIKLLLNYIDRNPDSIRTSNLFHSMTLTIIFKIVFNIDTDFDDEKIKKYIKNVQII-TSSNLTFSNAVFPLTNVPLLKYCVPSVLRIKKAMDNNVNILTELWKESK--ENCETNELE---SSSIGEFYLKQLQLTKVYEEEHQHLNDMNFIRNFSDIVGAGSDTVAATLAWCCLLLADRVKIQNKLRSEINEFVEVKSVIFFSYSDKSQLPYLCSFIEEVHRYFTIIPRTVHRPMKNLIFHGYKLLENDIILGDSYTSNHNADIWPNADKFIFDRFVENKEEKIKHL---QENFYPFGTGKRNCIGESLARKEVLLTLVALICHYKIELTNESKLNFEEILNGENGLVFAPFCHNL 497