HPO
|
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30030624 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 5
Homology
BLAST of HPO vs. Ensembl Human
Match: STK4 (serine/threonine kinase 4 [Source:HGNC Symbol;Acc:HGNC:11408]) HSP 1 Score: 463.381 bits (1191), Expect = 7.531e-159 Identity = 242/472 (51.27%), Postives = 328/472 (69.49%), Query Frame = 3
Query: 18 MEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIRENRQH-EEDTIQSRGSVTEEERTTDNGTMVRCSGD------TATSLSSESSMIVRDSLSSSVEAPTMLINATDDDSEAGGDTLTEQPHKSNKSPSQFAHQKKLQENGVKESAAQSPCGPLNPNAFVNVEE--IYRNLETKSYNELQQLLSRIDSDLQAELNNLEIRYLHKRQPILDAISEKSK 1406
++KL +D L K+P EVF + KLG+GSYGSVYKA HK+ G VA K VPV+S+L +I+KEISIMQQC S ++V+YYGS++ + DLWIVMEYCGAGSVSDI+RLRNKT E+EIA ILQ +LKGLEY+H ++KIHRDIKAGNILL EG+AKLADFGVAGQL+DT+AKRNTVIGTP+WMAPEVIQEIGY+ ADIWSLGITAIEMA+GKPPYADIHPMRA+FMIP+ PPPT P +WS +F +F+ QCLVK+P+QR +A+QLL + F+ +A L I +A +++ RQ ++ + EE D+GTMVR GD A++++ ++ ++ + + TM+INA D++ E E + S ++ QK+ +EN + S +S GPL ++ + + Y L++ + +LQ+ L +D ++ E+ + +Y KRQPILDAI K +
Sbjct: 14 LKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQH-PFVRSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKE-KENQIN-SFGKSVPGPLKNSSDWKIPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAKKR 482
BLAST of HPO vs. Ensembl Human
Match: STK3 (serine/threonine kinase 3 [Source:HGNC Symbol;Acc:HGNC:11406]) HSP 1 Score: 454.136 bits (1167), Expect = 3.326e-155 Identity = 245/477 (51.36%), Postives = 321/477 (67.30%), Query Frame = 3
Query: 18 MEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIRENRQHEEDTIQSRGSVTEEERTTDNGTMVRCSGDT-----ATSLSSES--SMIVRDSLSSSVEAPTMLINATDDDSEAGGDTLTEQPHKSNKSPSQFAHQKKLQENGVKESAAQS--PCGPLNPNAFVNVEEI-----YRNLETKSYNELQQLLSRIDSDLQAELNNLEIRYLHKRQPILDAISEKSK 1406
++KL +D L K+P EVF + KLG+GSYGSV+KA HK++G VA K VPV+S+L +I+KEISIMQQC S Y+V+YYGS++ + DLWIVMEYCGAGSVSDI+RLRNKT E+EIA IL+ +LKGLEY+H ++KIHRDIKAGNILL EG+AKLADFGVAGQL+DT+AKRNTVIGTP+WMAPEVIQEIGY+ ADIWSLGIT+IEMA+GKPPYADIHPMRA+FMIP+ PPPT P +WS F +F+ +CLVKNP+QR +A+QLL + FI NA L I +A EI+ R E+ +E D+ TMV+ S ++ ATS SE +MI +S + TM+IN+ D++ E G + + K+ +N E+ Q+ P++ N F + ++ + L+ S ELQ L +D ++ E+ L RY KRQPILDA+ K +
Sbjct: 11 LKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQH-PFIKNAKPVSILRDLITEAMEIKAKRHEEQQRELEEEEENSDEDELDSHTMVKTSVESVGTMRATSTMSEGAQTMIEHNSTMLESDLGTMVINSEDEEEEDGTMKRNATSPQVQRPSFMDYFDKQDFKNKSHENCNQNMHEPFPMSKNVFPDNWKVPQDGDFDFLKNLSLEELQMRLKALDPMMEREIEELRQRYTAKRQPILDAMDAKKR 486
BLAST of HPO vs. Ensembl Human
Match: STK3 (serine/threonine kinase 3 [Source:HGNC Symbol;Acc:HGNC:11406]) HSP 1 Score: 454.521 bits (1168), Expect = 5.691e-155 Identity = 245/477 (51.36%), Postives = 321/477 (67.30%), Query Frame = 3
Query: 18 MEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIRENRQHEEDTIQSRGSVTEEERTTDNGTMVRCSGDT-----ATSLSSES--SMIVRDSLSSSVEAPTMLINATDDDSEAGGDTLTEQPHKSNKSPSQFAHQKKLQENGVKESAAQS--PCGPLNPNAFVNVEEI-----YRNLETKSYNELQQLLSRIDSDLQAELNNLEIRYLHKRQPILDAISEKSK 1406
++KL +D L K+P EVF + KLG+GSYGSV+KA HK++G VA K VPV+S+L +I+KEISIMQQC S Y+V+YYGS++ + DLWIVMEYCGAGSVSDI+RLRNKT E+EIA IL+ +LKGLEY+H ++KIHRDIKAGNILL EG+AKLADFGVAGQL+DT+AKRNTVIGTP+WMAPEVIQEIGY+ ADIWSLGIT+IEMA+GKPPYADIHPMRA+FMIP+ PPPT P +WS F +F+ +CLVKNP+QR +A+QLL + FI NA L I +A EI+ R E+ +E D+ TMV+ S ++ ATS SE +MI +S + TM+IN+ D++ E G + + K+ +N E+ Q+ P++ N F + ++ + L+ S ELQ L +D ++ E+ L RY KRQPILDA+ K +
Sbjct: 39 LKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQH-PFIKNAKPVSILRDLITEAMEIKAKRHEEQQRELEEEEENSDEDELDSHTMVKTSVESVGTMRATSTMSEGAQTMIEHNSTMLESDLGTMVINSEDEEEEDGTMKRNATSPQVQRPSFMDYFDKQDFKNKSHENCNQNMHEPFPMSKNVFPDNWKVPQDGDFDFLKNLSLEELQMRLKALDPMMEREIEELRQRYTAKRQPILDAMDAKKR 514
BLAST of HPO vs. Ensembl Human
Match: STK4 (serine/threonine kinase 4 [Source:HGNC Symbol;Acc:HGNC:11408]) HSP 1 Score: 437.187 bits (1123), Expect = 6.666e-149 Identity = 224/409 (54.77%), Postives = 294/409 (71.88%), Query Frame = 3
Query: 18 MEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIRENRQH-EEDTIQSRGSVTEEERTTDNGTMVRCSGD------TATSLSSESSMIVRDSLSSSVEAPTMLINATDDDSEAGGDTLTEQPHKSNKSPSQFAHQKKLQENGVKESAAQSPCGPL 1223
++KL +D L K+P EVF + KLG+GSYGSVYKA HK+ G VA K VPV+S+L +I+KEISIMQQC S ++V+YYGS++ + DLWIVMEYCGAGSVSDI+RLRNKT E+EIA ILQ +LKGLEY+H ++KIHRDIKAGNILL EG+AKLADFGVAGQL+DT+AKRNTVIGTP+WMAPEVIQEIGY+ ADIWSLGITAIEMA+GKPPYADIHPMRA+FMIP+ PPPT P +WS +F +F+ QCLVK+P+QR +A+QLL + F+ +A L I +A +++ RQ ++ + EE D+GTMVR GD A++++ ++ ++ + + TM+INA D++ E E + S ++ QK+ +EN + S +S GPL
Sbjct: 14 LKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQH-PFVRSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKE-KENQIN-SFGKSVPGPL 419
BLAST of HPO vs. Ensembl Human
Match: STK4 (serine/threonine kinase 4 [Source:HGNC Symbol;Acc:HGNC:11408]) HSP 1 Score: 315.079 bits (806), Expect = 1.156e-101 Identity = 187/472 (39.62%), Postives = 269/472 (56.99%), Query Frame = 3
Query: 18 MEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIRENRQH-EEDTIQSRGSVTEEERTTDNGTMVRCSGD------TATSLSSESSMIVRDSLSSSVEAPTMLINATDDDSEAGGDTLTEQPHKSNKSPSQFAHQKKLQENGVKESAAQSPCGPLNPNAFVNVEE--IYRNLETKSYNELQQLLSRIDSDLQAELNNLEIRYLHKRQPILDAISEKSK 1406
++KL +D L K+P EVF + KLG+GSYGSVYKA HK+ G VA K VPV+S+L +I+KEISIMQQC S ++V+YYGS++ + DLWIV +EY G ++D +DT+AKRNTVIGTP+WMAPEVIQEIGY+ ADIWSLGITAIEMA+GKPPYADIHPMRA+FMIP+ PPPT P +WS +F +F+ QCLVK+P+QR +A+QLL + F+ +A L I +A +++ RQ ++ + EE D+GTMVR GD A++++ ++ ++ + + TM+INA D++ E E + S ++ QK+ +EN + S +S GPL ++ + + Y L++ + +LQ+ L +D ++ E+ + +Y KRQPILDAI K +
Sbjct: 14 LKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIV-----------------------------------MEYC--------------------GAGSVSDIIRLRNKTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQH-PFVRSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKE-KENQIN-SFGKSVPGPLKNSSDWKIPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAKKR 427
BLAST of HPO vs. Ensembl Celegans
Match: cst-1 (Serine/threonine-protein kinase cst-1 Serine/threonine-protein kinase cst-1 37kDa subunit Serine/threonine-protein kinase cst-1 18kDa subunit [Source:UniProtKB/Swiss-Prot;Acc:Q9NB31]) HSP 1 Score: 410.223 bits (1053), Expect = 2.011e-138 Identity = 231/497 (46.48%), Postives = 300/497 (60.36%), Query Frame = 3
Query: 24 KLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCE--FIINASSPDHLIATIKQANEIRENRQHEEDTIQSRGSVTEEERTTDNGTMVRCSGDTATSLSSESSMIVRDSLSSSVEAPTMLINATDDDSEAGGDTLTEQPHKSNKSPSQFAHQKKLQENGVKESA---------AQSPCGP---LNPNA---------FVNVEEIYRN-------------LETKSYNELQQLLSRIDSDLQAELNNLEIRYLHKRQPILDAISEKSK 1406
KL L K P EVF I KLG+GSYGSV+KA H+++G +A K VPVD++L +I+KEISIMQQCKS Y+V+YYGS++ DLWIVMEYCGAGS+SDIMR R K +E+EI+ +L+ +LKGL+Y+H LKKIHRDIKAGNILL +G AKLADFGVAGQL+DT+AKRNTVIGTP+WMAPEVI+EIGY ADIWSLGITAIEMA+G+PPY+DIHPMRA+FMIP++PPPT P WS F +FI CL+K P++R +A +L CE FI NA D + I+ A +E+ M SG+ AT LS S ++ S+ V+ + A S+ + + KS S S+ + ++Q G SA AQ GP L + +N E Y N L + +EL + +DS+++ E+ L+ RY KRQPILD I K +
Sbjct: 21 KLDSSALNKPPEEVFDIVGKLGEGSYGSVHKAIHRESGHVLAIKKVPVDTDLQEIIKEISIMQQCKSKYVVKYYGSYFKHSDLWIVMEYCGAGSISDIMRARRKPLSEQEISAVLRDTLKGLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDTKADIWSLGITAIEMAEGRPPYSDIHPMRAIFMIPTKPPPTFKKPEEWSSEFNDFIRSCLIKKPEERKTALRL---CEHTFIKNAPGCDIMQLMIQDA---------------------QEKAILGQAPMAASSGNDATLLSEGMSTMIDGGESTLVQHKDNYVTAQSLRSQMESLRIGGEIPKSAYSSSKNGNSPRVQPPGHTASASDPSKNQPFAQDGTGPNFQLGTSESSYKDASYNMMNTEAEYENRFQRAVVDGDFEFLRNITLDELIRRKESLDSEMEEEIRELQRRYKTKRQPILDVIEIKKR 493
BLAST of HPO vs. Ensembl Celegans
Match: cst-1 (Serine/threonine-protein kinase cst-1 Serine/threonine-protein kinase cst-1 37kDa subunit Serine/threonine-protein kinase cst-1 18kDa subunit [Source:UniProtKB/Swiss-Prot;Acc:Q9NB31]) HSP 1 Score: 407.142 bits (1045), Expect = 3.868e-137 Identity = 233/489 (47.65%), Postives = 304/489 (62.17%), Query Frame = 3
Query: 24 KLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCE--FIINASSPDHLIATIKQANEIRENRQH-------EEDTIQSRGSVTEEERTTDNG--TMVRCSGDTATSLSSESSMIVRDSLSSSVEAPTMLINATDDDSEAGGDTLTEQPHKSNKSPSQFAHQKKLQENGV----KESAAQSPCGPLNPNAFVNVEEIYRN-------------LETKSYNELQQLLSRIDSDLQAELNNLEIRYLHKRQPILDAISEKSK 1406
KL L K P EVF I KLG+GSYGSV+KA H+++G +A K VPVD++L +I+KEISIMQQCKS Y+V+YYGS++ DLWIVMEYCGAGS+SDIMR R K +E+EI+ +L+ +LKGL+Y+H LKKIHRDIKAGNILL +G AKLADFGVAGQL+DT+AKRNTVIGTP+WMAPEVI+EIGY ADIWSLGITAIEMA+G+PPY+DIHPMRA+FMIP++PPPT P WS F +FI CL+K P++R +A +L CE FI NA D + I+ A E Q + T+ S G T D G T+V+ + T+ S S M +SL E P +A S G++ QP S S + + ++G + ++S + N +N E Y N L + +EL + +DS+++ E+ L+ RY KRQPILD I K +
Sbjct: 21 KLDSSALNKPPEEVFDIVGKLGEGSYGSVHKAIHRESGHVLAIKKVPVDTDLQEIIKEISIMQQCKSKYVVKYYGSYFKHSDLWIVMEYCGAGSISDIMRARRKPLSEQEISAVLRDTLKGLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDTKADIWSLGITAIEMAEGRPPYSDIHPMRAIFMIPTKPPPTFKKPEEWSSEFNDFIRSCLIKKPEERKTALRL---CEHTFIKNAPGCDIMQLMIQDAQEKAILGQAPMAASSGNDATLLSEGMST----MIDGGESTLVQHKDNYVTAQSLRSQM---ESLRIGGEIPK---SAYIPGSSKNGNSPRVQPPGHTASASDPSKNQPFAQDGTGPNFQLGTSESSYKDASYN-MMNTEAEYENRFQRAVVDGDFEFLRNITLDELIRRKESLDSEMEEEIRELQRRYKTKRQPILDVIEIKKR 495
BLAST of HPO vs. Ensembl Celegans
Match: cst-2 (Caenorhabditis STE20-like kinase [Source:UniProtKB/TrEMBL;Acc:Q304D8]) HSP 1 Score: 390.578 bits (1002), Expect = 1.112e-131 Identity = 204/395 (51.65%), Postives = 262/395 (66.33%), Query Frame = 3
Query: 24 KLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCE--FIINASSPDHLIATIKQANEIRENRQHEEDTIQSRGSVTEEERTTDNGTMVRCSGDTATSLSSESSMIVRDSLSSSVEAPTMLINATDDDSEAGGDTLTEQPHKSNKSPSQFAHQKKLQENGVKESAA 1202
KL L K P EVF I KLG+GSYGSV+KA H+++G +A K VPVD++L +I+KEISIMQQCKS Y+V+YYGS++ DLWIVMEYCGAGS+SDIMR R K +E+EI+ +L+ +LKGL+Y+H LKKIHRDIKAGNILL +G AKLADFGVAGQL+DT+AKRNTVIGTP+WMAPEVI+EIGY ADIWSLGITAIEMA+G+PPY+DIHPMRA+FMIP++PPPT P WS F +FI CL+K P++R +A +L CE FI NA D + I+ A +E+ M SG+ AT LS S ++ S+ V+ + A S+ + + KS S S+ + ++Q G SA+
Sbjct: 21 KLDSSALNKPPEEVFDIVGKLGEGSYGSVHKAIHRESGHVLAIKKVPVDTDLQEIIKEISIMQQCKSKYVVKYYGSYFKHSDLWIVMEYCGAGSISDIMRARRKPLSEQEISAVLRDTLKGLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDTKADIWSLGITAIEMAEGRPPYSDIHPMRAIFMIPTKPPPTFKKPEEWSSEFNDFIRSCLIKKPEERKTALRL---CEHTFIKNAPGCDIMQLMIQDA---------------------QEKAILGQAPMAASSGNDATLLSEGMSTMIDGGESTLVQHKDNYVTAQSLRSQMESLRIGGEIPKSAYSSSKNGNSPRVQPPGHTASAS 391
BLAST of HPO vs. Ensembl Celegans
Match: gck-1 (Germinal center kinase 1 [Source:UniProtKB/Swiss-Prot;Acc:H2L099]) HSP 1 Score: 294.278 bits (752), Expect = 8.920e-92 Identity = 137/281 (48.75%), Postives = 195/281 (69.40%), Query Frame = 3
Query: 51 EPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDS---ELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIR 884
+P +F + ++G+GS+G VYK + G VA K++ ++ E+ DI +EI ++ QC S Y+ +Y+GSF LWI+MEY G GS D+ + + +E IA+IL+ LKGLEY+H +KIHRDIKA N+L++E G+ K+ADFGVAGQL++T+ KR T +G+P+WMAPE+I++ Y Y ADIWSLGITAIE+A+G+PP++D+HPMR LF+IP PPP +L S WS F F+ CL K+P+ RPSAS LL + +FI A L+ I++A E R
Sbjct: 9 DPEVIFTKQERIGRGSFGEVYKGIDNRTGRVVAIKIIDLEQAEDEIEDIQQEIQVLSQCDSQYVTKYFGSFLKGSKLWIIMEYLGGGSALDLTK--SGKLDESHIAVILREILKGLEYLHSERKIHRDIKAANVLVSEHGDVKVADFGVAGQLTETVKKRITFVGSPFWMAPELIKQSSYDYKADIWSLGITAIELANGEPPHSDLHPMRVLFLIPKNPPP-VLQGSQWSKPFKEFVEMCLNKDPENRPSASTLLKH-QFIKRAKKNSILVDLIERAAEYR 285
BLAST of HPO vs. Ensembl Celegans
Match: gck-1 (Germinal center kinase 1 [Source:UniProtKB/Swiss-Prot;Acc:H2L099]) HSP 1 Score: 294.278 bits (752), Expect = 9.553e-92 Identity = 137/281 (48.75%), Postives = 195/281 (69.40%), Query Frame = 3
Query: 51 EPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDS---ELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIR 884
+P +F + ++G+GS+G VYK + G VA K++ ++ E+ DI +EI ++ QC S Y+ +Y+GSF LWI+MEY G GS D+ + + +E IA+IL+ LKGLEY+H +KIHRDIKA N+L++E G+ K+ADFGVAGQL++T+ KR T +G+P+WMAPE+I++ Y Y ADIWSLGITAIE+A+G+PP++D+HPMR LF+IP PPP +L S WS F F+ CL K+P+ RPSAS LL + +FI A L+ I++A E R
Sbjct: 14 DPEVIFTKQERIGRGSFGEVYKGIDNRTGRVVAIKIIDLEQAEDEIEDIQQEIQVLSQCDSQYVTKYFGSFLKGSKLWIIMEYLGGGSALDLTK--SGKLDESHIAVILREILKGLEYLHSERKIHRDIKAANVLVSEHGDVKVADFGVAGQLTETVKKRITFVGSPFWMAPELIKQSSYDYKADIWSLGITAIELANGEPPHSDLHPMRVLFLIPKNPPP-VLQGSQWSKPFKEFVEMCLNKDPENRPSASTLLKH-QFIKRAKKNSILVDLIERAAEYR 290
BLAST of HPO vs. Ensembl Fly
Match: hpo (gene:FBgn0261456 transcript:FBtr0331920) HSP 1 Score: 395.201 bits (1014), Expect = 4.657e-130 Identity = 198/353 (56.09%), Postives = 255/353 (72.24%), Query Frame = 3
Query: 18 MEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIRENRQHEED------TIQSRGSVTEE----ERTTDN------GTMV-RCSGDTATSLSSESSMIV 1025
++KL ++ L + P +VF I KLG+GSYGSVYKA HK++ VA KLVPV+S+L +I+KEISIMQQC S Y+V+YYGS++ +DLWI MEYCGAGSVSDIMRLR KT E+EIA IL +L+GL Y+H +KIHRDIKA NILL EG AKLADFGVAGQL+DT+AKRNTVIGTP+WMAPEVI+EIGY ADIWSLGITA+EMA+GKPPY +IHPMRA+FMIP +PPP+ P WS F++F+++CLVK PD R +A++LL + EFI NA L +++ IRE ++ Q++ T+E + TDN GT+V G+ S +S+++MI
Sbjct: 26 LKKLSEESLLQPPEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVESDLHEIIKEISIMQQCDSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDCVADIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRATATELLEH-EFIRNAKHRSILKPMLEETCAIREQQRANRSFGGVLAASQAKSLATQENGMQQHITDNAFMEDPGTLVPEKFGEYQQSSASDATMIA 377
BLAST of HPO vs. Ensembl Fly
Match: hpo (gene:FBgn0261456 transcript:FBtr0086500) HSP 1 Score: 395.201 bits (1014), Expect = 4.657e-130 Identity = 198/353 (56.09%), Postives = 255/353 (72.24%), Query Frame = 3
Query: 18 MEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIRENRQHEED------TIQSRGSVTEE----ERTTDN------GTMV-RCSGDTATSLSSESSMIV 1025
++KL ++ L + P +VF I KLG+GSYGSVYKA HK++ VA KLVPV+S+L +I+KEISIMQQC S Y+V+YYGS++ +DLWI MEYCGAGSVSDIMRLR KT E+EIA IL +L+GL Y+H +KIHRDIKA NILL EG AKLADFGVAGQL+DT+AKRNTVIGTP+WMAPEVI+EIGY ADIWSLGITA+EMA+GKPPY +IHPMRA+FMIP +PPP+ P WS F++F+++CLVK PD R +A++LL + EFI NA L +++ IRE ++ Q++ T+E + TDN GT+V G+ S +S+++MI
Sbjct: 26 LKKLSEESLLQPPEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVESDLHEIIKEISIMQQCDSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDCVADIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRATATELLEH-EFIRNAKHRSILKPMLEETCAIREQQRANRSFGGVLAASQAKSLATQENGMQQHITDNAFMEDPGTLVPEKFGEYQQSSASDATMIA 377
BLAST of HPO vs. Ensembl Fly
Match: GckIII (gene:FBgn0266465 transcript:FBtr0083399) HSP 1 Score: 278.87 bits (712), Expect = 1.303e-85 Identity = 134/290 (46.21%), Postives = 193/290 (66.55%), Query Frame = 3
Query: 51 EPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVD---SELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIRENRQHEEDT 911
+P +F + ++GKGS+G V+K + VA K++ ++ E+ DI +EI ++ QC S Y+ +YYGSF LWI+MEY G GS D+M+ + E I IIL+ LKGL+Y+H +K+HRDIKA N+LL+E+G+ KLADFGVAGQL++T +KRNT +GTP+WMAPEVI++ Y ADIWSLGITAIE+A G+PP +++HPMR LF+IP PP L ++ SF +F+ CL K+P+ RP+A + LL FI A +LI I + + + ++ E +T
Sbjct: 8 DPELIFTKQERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIDDIQQEIMVLSQCDSPYVTKYYGSFLKGTKLWIIMEYLGGGSALDLMKA--GSFEEMHIGIILREVLKGLDYLHSERKLHRDIKAANVLLSEQGDVKLADFGVAGQLTNTTSKRNTFVGTPFWMAPEVIKQSQYDAKADIWSLGITAIELAKGEPPNSELHPMRVLFLIPKNNPPQLTGS--YTKSFKDFVEACLNKDPENRPTAKE-LLKYPFIKKAKKNAYLIDLIDRFKKWKVSKGDESET 292
BLAST of HPO vs. Ensembl Fly
Match: hppy (gene:FBgn0263395 transcript:FBtr0340456) HSP 1 Score: 246.514 bits (628), Expect = 1.887e-71 Identity = 126/282 (44.68%), Postives = 184/282 (65.25%), Query Frame = 3
Query: 27 LLDDDL-QKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVD--SELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVI---QEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQ--PPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLL----LNCEFIINAS 836
+L D+ ++ P + +++ K+G G+YG VYKAK ++ A K++ ++ ++ I +EI +M+ C+ I+ YYGS+ LWI ME+CG GS+ DI ++ E +IA + + +LKGLEY+H + K+HRDIK NILLTE G+ KLADFGV+ Q++ T+ KR + IGTPYWMAPEV ++ GY+ DIW+ GITAIE+A+ +PP D+HPMRALF++ PPTL N WSP+F NFI L KNP +RP+A +LL + CE + +
Sbjct: 12 MLSSDISRRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDIQIIQQEIIMMRDCRHPNIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQVTGPL-TEVQIAYMCRETLKGLEYLHSMGKMHRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKRPTAERLLQHPFVQCEMSLRVA 292
BLAST of HPO vs. Ensembl Fly
Match: hppy (gene:FBgn0263395 transcript:FBtr0086503) HSP 1 Score: 246.514 bits (628), Expect = 2.212e-71 Identity = 126/282 (44.68%), Postives = 184/282 (65.25%), Query Frame = 3
Query: 27 LLDDDL-QKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVD--SELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVI---QEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQ--PPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLL----LNCEFIINAS 836
+L D+ ++ P + +++ K+G G+YG VYKAK ++ A K++ ++ ++ I +EI +M+ C+ I+ YYGS+ LWI ME+CG GS+ DI ++ E +IA + + +LKGLEY+H + K+HRDIK NILLTE G+ KLADFGV+ Q++ T+ KR + IGTPYWMAPEV ++ GY+ DIW+ GITAIE+A+ +PP D+HPMRALF++ PPTL N WSP+F NFI L KNP +RP+A +LL + CE + +
Sbjct: 12 MLSSDISRRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDIQIIQQEIIMMRDCRHPNIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQVTGPL-TEVQIAYMCRETLKGLEYLHSMGKMHRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKRPTAERLLQHPFVQCEMSLRVA 292
BLAST of HPO vs. Ensembl Zebrafish
Match: stk3 (serine/threonine kinase 3 (STE20 homolog, yeast) [Source:NCBI gene;Acc:324125]) HSP 1 Score: 439.499 bits (1129), Expect = 1.202e-149 Identity = 239/482 (49.59%), Postives = 327/482 (67.84%), Query Frame = 3
Query: 18 MEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIR-ENRQHEEDTIQSRGSVTEEERTTDNGTMVRCSGDTATSLSSESSMIVRDSLSSSVE---------APTMLINATDDDSEAGGDTLTEQPHKSN-KSPSQFAHQKKLQENGVKESA---AQSPCGPLNPNAFVNVEEI-----YRNLETKSYNELQQLLSRIDSDLQAELNNLEIRYLHKRQPILDAISEKSK 1406
++KL +D L K+P EVF + KLG+GSYGSV+KA HK++G VA K VPV+S+L +I+KEISIMQQC S Y+V+YYGS++ + DLWIVMEYCGAGSVSDI+RLRNKT E+EIA +L+ +LKGLEY+H ++KIHRDIKAGNILL EG+AKLADFGVAGQL+DT+AKRNTVIGTP+WMAPEVIQEIGY+ ADIWSLGIT+IEMA+GKPPYADIHPMRA+FMIP+ PPPT P WS F +F+ +CLVKNP+QR +A+QLL + FI+ A L I +A +++ + +Q ++ ++ +EEE D+ TMV+ ++A ++ + +M D + +E TM+IN+ D++ E ++ P + PS + K N +E Q PC ++ AF + ++ + L+ + ELQ L+ +D ++ E+ L RY KRQPILDA+ K +
Sbjct: 10 LKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATVLKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPEHWSDDFTDFVKKCLVKNPEQRATATQLLQH-PFIVGAKPVSILRDLITEAMDMKAKRQQEQQRELEEDDENSEEEVEVDSHTMVKSGSESAGTMRATGTM--SDGAQTMIEHGSTMLESNLGTMVINSDDEEEEEDLGSMRRNPTSQQIQRPSFMDYFDKQDSNKAQEGFNHNQQDPC-LISKTAFPDNWKVPQDGDFDFLKNLDFEELQMRLTALDPMMEREIEELRQRYTAKRQPILDAMDAKKR 487
BLAST of HPO vs. Ensembl Zebrafish
Match: stk3 (serine/threonine kinase 3 (STE20 homolog, yeast) [Source:NCBI gene;Acc:324125]) HSP 1 Score: 439.499 bits (1129), Expect = 1.202e-149 Identity = 239/482 (49.59%), Postives = 327/482 (67.84%), Query Frame = 3
Query: 18 MEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIR-ENRQHEEDTIQSRGSVTEEERTTDNGTMVRCSGDTATSLSSESSMIVRDSLSSSVE---------APTMLINATDDDSEAGGDTLTEQPHKSN-KSPSQFAHQKKLQENGVKESA---AQSPCGPLNPNAFVNVEEI-----YRNLETKSYNELQQLLSRIDSDLQAELNNLEIRYLHKRQPILDAISEKSK 1406
++KL +D L K+P EVF + KLG+GSYGSV+KA HK++G VA K VPV+S+L +I+KEISIMQQC S Y+V+YYGS++ + DLWIVMEYCGAGSVSDI+RLRNKT E+EIA +L+ +LKGLEY+H ++KIHRDIKAGNILL EG+AKLADFGVAGQL+DT+AKRNTVIGTP+WMAPEVIQEIGY+ ADIWSLGIT+IEMA+GKPPYADIHPMRA+FMIP+ PPPT P WS F +F+ +CLVKNP+QR +A+QLL + FI+ A L I +A +++ + +Q ++ ++ +EEE D+ TMV+ ++A ++ + +M D + +E TM+IN+ D++ E ++ P + PS + K N +E Q PC ++ AF + ++ + L+ + ELQ L+ +D ++ E+ L RY KRQPILDA+ K +
Sbjct: 10 LKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATVLKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPEHWSDDFTDFVKKCLVKNPEQRATATQLLQH-PFIVGAKPVSILRDLITEAMDMKAKRQQEQQRELEEDDENSEEEVEVDSHTMVKSGSESAGTMRATGTM--SDGAQTMIEHGSTMLESNLGTMVINSDDEEEEEDLGSMRRNPTSQQIQRPSFMDYFDKQDSNKAQEGFNHNQQDPC-LISKTAFPDNWKVPQDGDFDFLKNLDFEELQMRLTALDPMMEREIEELRQRYTAKRQPILDAMDAKKR 487
BLAST of HPO vs. Ensembl Zebrafish
Match: stk25b (serine/threonine kinase 25b [Source:ZFIN;Acc:ZDB-GENE-040426-2537]) HSP 1 Score: 269.626 bits (688), Expect = 1.651e-84 Identity = 130/255 (50.98%), Postives = 175/255 (68.63%), Query Frame = 3
Query: 51 EPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIV---KEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLL 806
+P E F + ++GKGS+G VYK + + VA K++ ++ +I +EI+++ QC S Y+ +YYGS+ LWI+MEY G GS D+ L+ E IA IL+ LKGLEY+H +KIHRDIKA N+LL+E+G+ KLADFGVAGQL+DT KRNT +GTP+WMAPEVI++ Y + ADIWSLGITAIE+A G+PP +D+HPMR LF+IP PPTL +S F F+ CL K+P RP+A +LL
Sbjct: 15 DPEEYFTKQERIGKGSFGEVYKGINNRTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKGTKLWIIMEYLGGGSALDL--LKPGPLEETYIATILREILKGLEYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNTPPTL--EGSYSKPFKEFVEACLNKDPRFRPTAKELL 265
BLAST of HPO vs. Ensembl Zebrafish
Match: stk25a (serine/threonine kinase 25a [Source:ZFIN;Acc:ZDB-GENE-041010-92]) HSP 1 Score: 269.24 bits (687), Expect = 2.063e-84 Identity = 131/254 (51.57%), Postives = 173/254 (68.11%), Query Frame = 3
Query: 54 PSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIV---KEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLL 806
P E F ++GKGS+G VYK + + VA K++ ++ +I +EI+++ QC S Y+ +YYGS+ LWI+MEY G GS D+ LR T E IA IL+ LKGL+Y+H +KIHRDIKA N+LL+E G KLADFGVAGQL+DT KRNT +GTP+WMAPEVI++ Y + ADIWSLGITAIE+A G+PP A++HPMR LF+IP PPTL +S +F +F+ CL K P RP+A +LL
Sbjct: 16 PEEYFTKLERIGKGSFGEVYKGINNRTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLTGSKLWIIMEYLGGGSALDL--LRPGTLEEVYIATILREILKGLDYLHSERKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNAELHPMRVLFLIPKNNPPTL--EGSYSKAFKDFVEACLNKEPRFRPTAKELL 265
BLAST of HPO vs. Ensembl Zebrafish
Match: stk24a (serine/threonine kinase 24a (STE20 homolog, yeast) [Source:ZFIN;Acc:ZDB-GENE-070424-52]) HSP 1 Score: 267.7 bits (683), Expect = 9.061e-84 Identity = 127/259 (49.03%), Postives = 181/259 (69.88%), Query Frame = 3
Query: 39 DLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVD---SELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLL 806
+L+ +P ++F ++GKGS+G V+K + VA K++ ++ E+ DI +EI+++ QC S +I +Y+GS+ LWI+MEY G GS D+ L +E IA IL+ LKGL+Y+H KKIHRDIKA N+LL+E+G+ KLADFGVAGQL+DT KRNT +GTP+WMAPEVI++ Y ADIWSLGITAIE+A G+PP++D+HPM+ LF+IP + PPTL ++ + F+ CL K+P+ RP+A +LL
Sbjct: 8 NLKLDPEKLFTKLERIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEVEDIQQEITVLSQCDSLFITKYFGSYLKDTKLWIIMEYLGGGSALDL--LGPGALDETHIATILREILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSEYDSKADIWSLGITAIELAKGEPPHSDLHPMKVLFLIPKENPPTL--EGNYNKALKEFVDACLNKDPNFRPTAKELL 262
BLAST of HPO vs. Ensembl Xenopus
Match: elp4 (elongator acetyltransferase complex subunit 4 [Source:Xenbase;Acc:XB-GENE-991975]) HSP 1 Score: 444.121 bits (1141), Expect = 2.323e-151 Identity = 243/484 (50.21%), Postives = 324/484 (66.94%), Query Frame = 3
Query: 15 MMEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIRENRQHEEDTIQSRGSVTEEERTTDNGTMVRCSGDTATSLSSES-------SMIVRDSLSSSVEAPTMLINATDDDSEAGGDTLTEQPHKSNKSPS-QFAHQKKLQENGVKESAAQSPCGP-------LNPNAFVNVEEI-----YRNLETKSYNELQQLLSRIDSDLQAELNNLEIRYLHKRQPILDAISEKSK 1406
+++KL +D L K+P EVF + KLG+GSYGSV+KA HK++G VA K VPV+S+L +I+KEISIMQQC S Y+V+YYGS++ + DLWIVMEYCGAGSVSDI+RLRNKT EEEIA IL+ +LKGLEY+H ++KIHRDIKAGNILL EG+AKLADFGVAGQL+DT+AKRNTVIGTP+WMAPEVIQEIGY+ ADIWSLGIT+IEMA+GKPPYADIHPMRA+FMIP+ PPPT P +WS F +F+ +CLVKNP+QR +A+QLL + FI NA L I +A +I+ R E+ EE D+ TMV+ + ++A ++ + S +MI +S + TM+IN+ D++ E D ++ S + P F Q++ +S C ++ N F + ++ + L+ S+ ELQ L +D ++ E+ L RY KRQPILDA+ K +
Sbjct: 6 LLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSHYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEEEIATILRSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDEFTDFVKKCLVKNPEQRATATQLLQH-PFIKNAKPVSILRDLITEAMDIKAKRHEEQQRELEEEDENSEEDELDSHTMVKTNSESAGTMRAASTMSEGAQTMIEHNSTMLESDLGTMVINSDDEEEEEEEDGTMKRNATSPQVPRPSFMDYFDKQDS---KSKPHDNCNQNLHEQYHISKNVFPDNWKVPPDGDFDFLKNLSFEELQMRLKALDPMMEREIEELRQRYNAKRQPILDAMDAKKR 485
BLAST of HPO vs. Ensembl Xenopus
Match: elp4 (elongator acetyltransferase complex subunit 4 [Source:Xenbase;Acc:XB-GENE-991975]) HSP 1 Score: 444.121 bits (1141), Expect = 2.805e-151 Identity = 243/483 (50.31%), Postives = 323/483 (66.87%), Query Frame = 3
Query: 18 MEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIRENRQHEEDTIQSRGSVTEEERTTDNGTMVRCSGDTATSLSSES-------SMIVRDSLSSSVEAPTMLINATDDDSEAGGDTLTEQPHKSNKSPS-QFAHQKKLQENGVKESAAQSPCGP-------LNPNAFVNVEEI-----YRNLETKSYNELQQLLSRIDSDLQAELNNLEIRYLHKRQPILDAISEKSK 1406
++KL +D L K+P EVF + KLG+GSYGSV+KA HK++G VA K VPV+S+L +I+KEISIMQQC S Y+V+YYGS++ + DLWIVMEYCGAGSVSDI+RLRNKT EEEIA IL+ +LKGLEY+H ++KIHRDIKAGNILL EG+AKLADFGVAGQL+DT+AKRNTVIGTP+WMAPEVIQEIGY+ ADIWSLGIT+IEMA+GKPPYADIHPMRA+FMIP+ PPPT P +WS F +F+ +CLVKNP+QR +A+QLL + FI NA L I +A +I+ R E+ EE D+ TMV+ + ++A ++ + S +MI +S + TM+IN+ D++ E D ++ S + P F Q++ +S C ++ N F + ++ + L+ S+ ELQ L +D ++ E+ L RY KRQPILDA+ K +
Sbjct: 15 LKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSHYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEEEIATILRSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDEFTDFVKKCLVKNPEQRATATQLLQH-PFIKNAKPVSILRDLITEAMDIKAKRHEEQQRELEEEDENSEEDELDSHTMVKTNSESAGTMRAASTMSEGAQTMIEHNSTMLESDLGTMVINSDDEEEEEEEDGTMKRNATSPQVPRPSFMDYFDKQDS---KSKPHDNCNQNLHEQYHISKNVFPDNWKVPPDGDFDFLKNLSFEELQMRLKALDPMMEREIEELRQRYNAKRQPILDAMDAKKR 493
BLAST of HPO vs. Ensembl Xenopus
Match: elp4 (elongator acetyltransferase complex subunit 4 [Source:Xenbase;Acc:XB-GENE-991975]) HSP 1 Score: 444.121 bits (1141), Expect = 2.888e-151 Identity = 243/484 (50.21%), Postives = 324/484 (66.94%), Query Frame = 3
Query: 15 MMEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIRENRQHEEDTIQSRGSVTEEERTTDNGTMVRCSGDTATSLSSES-------SMIVRDSLSSSVEAPTMLINATDDDSEAGGDTLTEQPHKSNKSPS-QFAHQKKLQENGVKESAAQSPCGP-------LNPNAFVNVEEI-----YRNLETKSYNELQQLLSRIDSDLQAELNNLEIRYLHKRQPILDAISEKSK 1406
+++KL +D L K+P EVF + KLG+GSYGSV+KA HK++G VA K VPV+S+L +I+KEISIMQQC S Y+V+YYGS++ + DLWIVMEYCGAGSVSDI+RLRNKT EEEIA IL+ +LKGLEY+H ++KIHRDIKAGNILL EG+AKLADFGVAGQL+DT+AKRNTVIGTP+WMAPEVIQEIGY+ ADIWSLGIT+IEMA+GKPPYADIHPMRA+FMIP+ PPPT P +WS F +F+ +CLVKNP+QR +A+QLL + FI NA L I +A +I+ R E+ EE D+ TMV+ + ++A ++ + S +MI +S + TM+IN+ D++ E D ++ S + P F Q++ +S C ++ N F + ++ + L+ S+ ELQ L +D ++ E+ L RY KRQPILDA+ K +
Sbjct: 7 VLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSHYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEEEIATILRSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDEFTDFVKKCLVKNPEQRATATQLLQH-PFIKNAKPVSILRDLITEAMDIKAKRHEEQQRELEEEDENSEEDELDSHTMVKTNSESAGTMRAASTMSEGAQTMIEHNSTMLESDLGTMVINSDDEEEEEEEDGTMKRNATSPQVPRPSFMDYFDKQDS---KSKPHDNCNQNLHEQYHISKNVFPDNWKVPPDGDFDFLKNLSFEELQMRLKALDPMMEREIEELRQRYNAKRQPILDAMDAKKR 486
BLAST of HPO vs. Ensembl Xenopus
Match: elp4 (elongator acetyltransferase complex subunit 4 [Source:Xenbase;Acc:XB-GENE-991975]) HSP 1 Score: 443.736 bits (1140), Expect = 3.751e-151 Identity = 243/483 (50.31%), Postives = 323/483 (66.87%), Query Frame = 3
Query: 18 MEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIRENRQHEEDTIQSRGSVTEEERTTDNGTMVRCSGDTATSLSSES-------SMIVRDSLSSSVEAPTMLINATDDDSEAGGDTLTEQPHKSNKSPS-QFAHQKKLQENGVKESAAQSPCGP-------LNPNAFVNVEEI-----YRNLETKSYNELQQLLSRIDSDLQAELNNLEIRYLHKRQPILDAISEKSK 1406
++KL +D L K+P EVF + KLG+GSYGSV+KA HK++G VA K VPV+S+L +I+KEISIMQQC S Y+V+YYGS++ + DLWIVMEYCGAGSVSDI+RLRNKT EEEIA IL+ +LKGLEY+H ++KIHRDIKAGNILL EG+AKLADFGVAGQL+DT+AKRNTVIGTP+WMAPEVIQEIGY+ ADIWSLGIT+IEMA+GKPPYADIHPMRA+FMIP+ PPPT P +WS F +F+ +CLVKNP+QR +A+QLL + FI NA L I +A +I+ R E+ EE D+ TMV+ + ++A ++ + S +MI +S + TM+IN+ D++ E D ++ S + P F Q++ +S C ++ N F + ++ + L+ S+ ELQ L +D ++ E+ L RY KRQPILDA+ K +
Sbjct: 10 LKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSHYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEEEIATILRSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDEFTDFVKKCLVKNPEQRATATQLLQH-PFIKNAKPVSILRDLITEAMDIKAKRHEEQQRELEEEDENSEEDELDSHTMVKTNSESAGTMRAASTMSEGAQTMIEHNSTMLESDLGTMVINSDDEEEEEEEDGTMKRNATSPQVPRPSFMDYFDKQDS---KSKPHDNCNQNLHEQYHISKNVFPDNWKVPPDGDFDFLKNLSFEELQMRLKALDPMMEREIEELRQRYNAKRQPILDAMDAKKR 488
BLAST of HPO vs. Ensembl Xenopus
Match: elp4 (elongator acetyltransferase complex subunit 4 [Source:Xenbase;Acc:XB-GENE-991975]) HSP 1 Score: 441.039 bits (1133), Expect = 9.455e-151 Identity = 236/464 (50.86%), Postives = 307/464 (66.16%), Query Frame = 3
Query: 18 MEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIRENRQHEEDTIQSRGSVTEEERTTDNGTMVRCSGDTATSLSSESSMIVRDSLSSSVEAPTML-INATDDDSEAGGDTLTEQPHKSNKSPSQFAHQKKLQENGVKESAAQSPCGPLNPNAFVNVEEIYRNLETKSYNELQQLLSRIDSDLQAELNNLEIRYLHKRQPILDAISEKSK 1406
++KL +D L K+P EVF + KLG+GSYGSV+KA HK++G VA K VPV+S+L +I+KEISIMQQC S Y+V+YYGS++ + DLWIVMEYCGAGSVSDI+RLRNKT EEEIA IL+ +LKGLEY+H ++KIHRDIKAGNILL EG+AKLADFGVAGQL+DT+AKRNTVIGTP+WMAPEVIQEIGY+ ADIWSLGIT+IEMA+GKPPYADIHPMRA+FMIP+ PPPT P +WS F +F+ +CLVKNP+QR +A+QLL + FI NA L I +A +I+ R E+ EE D+ TMV+ + ++A ++ + S+M S A TM+ N+T +S+ G + N E + G + F ++ + + ELQ L +D ++ E+ L RY KRQPILDA+ K +
Sbjct: 12 LKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSHYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEEEIATILRSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDEFTDFVKKCLVKNPEQRATATQLLQH-PFIKNAKPVSILRDLITEAMDIKAKRHEEQQRELEEEDENSEEDELDSHTMVKTNSESAGTMRAASTM--------SEGAQTMIEHNSTMLESDLGTMVI----------------------NSDDEEEEEEEDGTMKSRFFW----LFHSPLLFLFEELQMRLKALDPMMEREIEELRQRYNAKRQPILDAMDAKKR 440
BLAST of HPO vs. Ensembl Mouse
Match: Stk4 (serine/threonine kinase 4 [Source:MGI Symbol;Acc:MGI:1929004]) HSP 1 Score: 460.685 bits (1184), Expect = 5.013e-158 Identity = 240/472 (50.85%), Postives = 328/472 (69.49%), Query Frame = 3
Query: 18 MEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIRENRQH-EEDTIQSRGSVTEEERTTDNGTMVRCSGD------TATSLSSESSMIVRDSLSSSVEAPTMLINATDDDSEAGGDTLTEQPHKSNKSPSQFAHQKKLQENGVKESAAQSPCGPLNPNAFVNVEE--IYRNLETKSYNELQQLLSRIDSDLQAELNNLEIRYLHKRQPILDAISEKSK 1406
++KL +D L K+P EVF + KLG+GSYGSVYKA HK+ G VA K VPV+S+L +I+KEISIMQQC S ++V+YYGS++ + DLWIVMEYCGAGSVSDI+RLRNKT E+EIA ILQ +LKGLEY+H ++KIHRDIKAGNILL EG+AKLADFGVAGQL+DT+AKRNTVIGTP+WMAPEVIQEIGY+ ADIWSLGITAIEMA+GKPPYADIHPMRA+FMIP+ PPPT P +WS +F++F+ QCLVK+P+QR +A+QLL + F+ +A L I +A +++ RQ ++ + EE D+GTMVR +GD A+++S ++ ++ + + TM+IN D++ E E + S ++ QK+ +EN + S ++ G L ++ + + Y L++ + +LQ+ L +D ++ E+ + +Y KRQPILDAI K +
Sbjct: 14 LKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFMDFVKQCLVKSPEQRATATQLLQH-PFVKSAKGVSILRDLINEAMDVKLKRQEAQQREVDQDDEENSEEDEMDSGTMVRAAGDEMGTVRVASTMSGGANTMIEHGDTLPSQLGTMVINTEDEEEEGTMKRRDETMQPAKPSFLEYFEQKE-KENQIN-SFGKNVSGSLKNSSDWKIPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEMEEIRQKYRSKRQPILDAIEAKKR 482
BLAST of HPO vs. Ensembl Mouse
Match: Stk3 (serine/threonine kinase 3 [Source:MGI Symbol;Acc:MGI:1928487]) HSP 1 Score: 446.432 bits (1147), Expect = 2.785e-152 Identity = 246/483 (50.93%), Postives = 324/483 (67.08%), Query Frame = 3
Query: 18 MEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIRENRQHEEDTIQSRGSVTEEERTTDNGTMVRCSGDT-----ATSLSSES--SMIVRDSLSSSVEAPTMLINATDDDSEAGGDTLTEQPHKSNKSPS----QFA--HQKKLQENGVKESAAQS--PCGPLNPNAFVNVEEI-----YRNLETKSYNELQQLLSRIDSDLQAELNNLEIRYLHKRQPILDAISEKSK 1406
++KL +D L K+P EVF + KLG+GSYGSV+KA HK++G VA K VPV+S+L +I+KEISIMQQC S Y+V+YYGS++ + DLWIVMEYCGAGSVSDI+RLRNKT E+EIA IL+ +LKGLEY+H ++KIHRDIKAGNILL EG+AKLADFGVAGQL+DT+AKRNTVIGTP+WMAPEVIQEIGY+ ADIWSLGIT+IEMA+GKPPYADIHPMRA+FMIP+ PPPT P +WS F +F+ +CLVK+P+QR +A+QLL + FI NA L I +A EI+ R E+ +E D+ TMV+ S ++ ATS SE +MI +S + TM+IN+ +++ E + ++ SP F K+ +N E+ QS GP++ + F + + + L+ S ELQ L +D ++ E+ L RY KRQPILDA+ K +
Sbjct: 9 LKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKSPEQRATATQLLQH-PFIKNAKPVSILRDLIAEAMEIKAKRHEEQQRELEEEEENSDEDELDSHTMVKTSSESVGTMRATSTMSEGAQTMIEHNSTMLESDLGTMVINSEEEEEEEEEEEEDGTMKRNATSPQVQRPSFMDYFDKQDFKNKSHENCDQSMREPGPMSNSVFPDNWRVPQDGDFDFLKNLSLEELQMRLKALDPMMEREIEELHQRYSAKRQPILDAMDAKKR 490
BLAST of HPO vs. Ensembl Mouse
Match: Stk3 (serine/threonine kinase 3 [Source:MGI Symbol;Acc:MGI:1928487]) HSP 1 Score: 446.432 bits (1147), Expect = 2.943e-152 Identity = 246/483 (50.93%), Postives = 324/483 (67.08%), Query Frame = 3
Query: 18 MEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIRENRQHEEDTIQSRGSVTEEERTTDNGTMVRCSGDT-----ATSLSSES--SMIVRDSLSSSVEAPTMLINATDDDSEAGGDTLTEQPHKSNKSPS----QFA--HQKKLQENGVKESAAQS--PCGPLNPNAFVNVEEI-----YRNLETKSYNELQQLLSRIDSDLQAELNNLEIRYLHKRQPILDAISEKSK 1406
++KL +D L K+P EVF + KLG+GSYGSV+KA HK++G VA K VPV+S+L +I+KEISIMQQC S Y+V+YYGS++ + DLWIVMEYCGAGSVSDI+RLRNKT E+EIA IL+ +LKGLEY+H ++KIHRDIKAGNILL EG+AKLADFGVAGQL+DT+AKRNTVIGTP+WMAPEVIQEIGY+ ADIWSLGIT+IEMA+GKPPYADIHPMRA+FMIP+ PPPT P +WS F +F+ +CLVK+P+QR +A+QLL + FI NA L I +A EI+ R E+ +E D+ TMV+ S ++ ATS SE +MI +S + TM+IN+ +++ E + ++ SP F K+ +N E+ QS GP++ + F + + + L+ S ELQ L +D ++ E+ L RY KRQPILDA+ K +
Sbjct: 11 LKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKSPEQRATATQLLQH-PFIKNAKPVSILRDLIAEAMEIKAKRHEEQQRELEEEEENSDEDELDSHTMVKTSSESVGTMRATSTMSEGAQTMIEHNSTMLESDLGTMVINSEEEEEEEEEEEEDGTMKRNATSPQVQRPSFMDYFDKQDFKNKSHENCDQSMREPGPMSNSVFPDNWRVPQDGDFDFLKNLSLEELQMRLKALDPMMEREIEELHQRYSAKRQPILDAMDAKKR 492
BLAST of HPO vs. Ensembl Mouse
Match: Stk3 (serine/threonine kinase 3 [Source:MGI Symbol;Acc:MGI:1928487]) HSP 1 Score: 365.155 bits (936), Expect = 1.811e-121 Identity = 206/416 (49.52%), Postives = 271/416 (65.14%), Query Frame = 3
Query: 219 KSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIRENRQHEEDTIQSRGSVTEEERTTDNGTMVRCSGDT-----ATSLSSES--SMIVRDSLSSSVEAPTMLINATDDDSEAGGDTLTEQPHKSNKSPS----QFA--HQKKLQENGVKESAAQS--PCGPLNPNAFVNVEEI-----YRNLETKSYNELQQLLSRIDSDLQAELNNLEIRYLHKRQPILDAISEKSK 1406
KS Y+V+YYGS++ + DLWIVMEYCGAGSVSDI+RLRNKT E+EIA IL+ +LKGLEY+H ++KIHRDIKAGNILL EG+AKLADFGVAGQL+DT+AKRNTVIGTP+WMAPEVIQEIGY+ ADIWSLGIT+IEMA+GKPPYADIHPMRA+FMIP+ PPPT P +WS F +F+ +CLVK+P+QR +A+QLL + FI NA L I +A EI+ R E+ +E D+ TMV+ S ++ ATS SE +MI +S + TM+IN+ +++ E + ++ SP F K+ +N E+ QS GP++ + F + + + L+ S ELQ L +D ++ E+ L RY KRQPILDA+ K +
Sbjct: 8 KSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKSPEQRATATQLLQH-PFIKNAKPVSILRDLIAEAMEIKAKRHEEQQRELEEEEENSDEDELDSHTMVKTSSESVGTMRATSTMSEGAQTMIEHNSTMLESDLGTMVINSEEEEEEEEEEEEDGTMKRNATSPQVQRPSFMDYFDKQDFKNKSHENCDQSMREPGPMSNSVFPDNWRVPQDGDFDFLKNLSLEELQMRLKALDPMMEREIEELHQRYSAKRQPILDAMDAKKR 422
BLAST of HPO vs. Ensembl Mouse
Match: Stk26 (serine/threonine kinase 26 [Source:MGI Symbol;Acc:MGI:1917665]) HSP 1 Score: 272.322 bits (695), Expect = 5.952e-86 Identity = 134/274 (48.91%), Postives = 184/274 (67.15%), Query Frame = 3
Query: 51 EPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIV---KEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATI 863
+P E+F ++GKGS+G V+K + VA K++ ++ +I +EI+++ QC S Y+ +YYGS+ LWI+MEY G GS D+ LR +E +IA +L+ LKGL+Y+H KKIHRDIKA N+LL+E+G+ KLADFGVAGQL+DT KRNT +GTP+WMAPEVIQ+ Y ADIWSLGITAIE+A G+PP +D+HPMR LF+IP PPTL+ ++ SF FI CL K+P RP+A +LL + + N+ +L I
Sbjct: 19 DPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDL--LRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLIGD--FTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELI 288
BLAST of HPO vs. UniProt/SwissProt
Match: sp|A4K2S1|STK4_LEMCA (Serine/threonine-protein kinase 4 OS=Lemur catta OX=9447 GN=STK4 PE=3 SV=1) HSP 1 Score: 470.7 bits (1210), Expect = 3.960e-161 Identity = 247/472 (52.33%), Postives = 330/472 (69.92%), Query Frame = 3
Query: 18 MEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIRENRQH-EEDTIQSRGSVTEEERTTDNGTMVRCSGD------TATSLSSESSMIVRDSLSSSVEAPTMLINATDDDSEAGGDTLTEQPHKSNKSPSQFAHQKKLQENGVKESAAQSPCGPLNPNAFVNVEE--IYRNLETKSYNELQQLLSRIDSDLQAELNNLEIRYLHKRQPILDAISEKSK 1406
++KL +D L K+P EVF + KLG+GSYGSVYKA HK+ G VA K VPV+S+L +I+KEISIMQQC S ++V+YYGS++ + DLWIVMEYCGAGSVSDI+RLRNKT E+EIA ILQ +LKGLEY+H ++KIHRDIKAGNILL EG+AKLADFGVAGQL+DT+AKRNTVIGTP+WMAPEVIQEIGY+ ADIWSLGITAIEMA+GKPPYADIHPMRA+FMIP+ PPPT P +WS +F++F+ QCLVK+PDQR +A+QLL + F+ +A L I +A +++ RQ ++ + EE D+GTMVR GD A+++S E++ ++ + + TM+INA D++ E E + S ++ QK+ +EN + S +S GPL +A V + Y L++ + +LQ+ L +D ++ E+ + +Y KRQPILDAI K +
Sbjct: 14 LKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFMDFVRQCLVKSPDQRATATQLLQH-PFVKSAKGVSILRDLINEAMDVKLKRQEAQQREVDQDDEENSEEDELDSGTMVRAVGDDMGTVRVASTMSDEANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKE-KENQIS-SFGKSVPGPLKNSADWKVPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAKKR 482
BLAST of HPO vs. UniProt/SwissProt
Match: sp|Q5E9L6|STK4_BOVIN (Serine/threonine-protein kinase 4 OS=Bos taurus OX=9913 GN=STK4 PE=2 SV=1) HSP 1 Score: 469.159 bits (1206), Expect = 2.046e-160 Identity = 245/472 (51.91%), Postives = 329/472 (69.70%), Query Frame = 3
Query: 18 MEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIRENRQH-EEDTIQSRGSVTEEERTTDNGTMVRCSGD------TATSLSSESSMIVRDSLSSSVEAPTMLINATDDDSEAGGDTLTEQPHKSNKSPSQFAHQKKLQENGVKESAAQSPCGPLNPNAFVNVEE--IYRNLETKSYNELQQLLSRIDSDLQAELNNLEIRYLHKRQPILDAISEKSK 1406
++KL +D L K+P EVF + KLG+GSYGSVYKA HK+ G VA K VPV+S+L +I+KEISIMQQC S ++V+YYGS++ + DLWIVMEYCGAGSVSDI+RLRNKT E+EIA ILQ +LKGLEY+H ++KIHRDIKAGNILL EG+AKLADFGVAGQL+DT+AKRNTVIGTP+WMAPEVIQEIGY+ ADIWSLGITAIEMA+GKPPYADIHPMRA+FMIP+ PPPT P +WS SF++F+ QCLVK+P+QR +A+QLL + F+ +A L I +A +++ RQ ++ + EE D+GTMVR +GD A+S+S ++ ++ + + TM+IN D++ E E + S ++ QK+ +EN + S +S GPL ++ V + Y L++ + +LQ+ L +D ++ E+ + +Y KRQPILDAI K +
Sbjct: 14 LKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDSFMDFVKQCLVKSPEQRATATQLLQH-PFVKSAKGVSILRDLINEAMDVKLKRQEAQQREVDQEEEENSEEDELDSGTMVRAAGDEMGTVRVASSMSDGANTMIEHDDTLPSQLGTMVINTEDEEEEGTMKRRDETMQPARPSFLEYFEQKE-KENQIN-SFGKSVPGPLQNSSDWKVPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAKKR 482
BLAST of HPO vs. UniProt/SwissProt
Match: sp|A4K2Q5|STK4_OTOGA (Serine/threonine-protein kinase 4 OS=Otolemur garnettii OX=30611 GN=STK4 PE=3 SV=1) HSP 1 Score: 466.077 bits (1198), Expect = 3.308e-159 Identity = 245/472 (51.91%), Postives = 328/472 (69.49%), Query Frame = 3
Query: 18 MEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIRENRQH-EEDTIQSRGSVTEEERTTDNGTMVRCSGD------TATSLSSESSMIVRDSLSSSVEAPTMLINATDDDSEAGGDTLTEQPHKSNKSPSQFAHQKKLQENGVKESAAQSPCGPLNPNAFVNVEE--IYRNLETKSYNELQQLLSRIDSDLQAELNNLEIRYLHKRQPILDAISEKSK 1406
++KL +D L K+P EVF + KLG+GSYGSVYKA HK+ G VA K VPV+S+L +I+KEISIMQQC S ++V+YYGS++ + DLWIVMEYCGAGSVSDI+RLRNKT E+EIA ILQ +LKGLEY+H ++KIHRDIKAGNILL EG+AKLADFGVAGQL+DT+AKRNTVIGTP+WMAPEVIQEIGY+ ADIWSLGITAIEMA+GKPPYADIHPMRA+FMIP+ PPPT P +WS +F +F+ QCLVK+PDQR +A+QLL + F+ +A L I +A +++ RQ ++ + EE D+GTMVR GD A+++S ++ ++ + + TM+INA D++ E E + S ++ QK+ +EN + S +S GPL ++ V + Y L++ + +LQ+ L +D ++ E+ + +Y KRQPILDAI K +
Sbjct: 14 LKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVRQCLVKSPDQRATATQLLQH-PFVKSAKGVSILRDLINEAMDVKLKRQEAQQREVDQDDEENSEEDELDSGTMVRAVGDEMGTVRVASTMSDGANTMIEHDDTLPSQLGTMVINADDEEEEGTMKRRDETMQPAKPSFLEYFEQKE-KENQIN-SFGKSVPGPLKNSSDWKVPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAKKR 482
BLAST of HPO vs. UniProt/SwissProt
Match: sp|Q802A6|STK4_SQUAC (Serine/threonine-protein kinase 3/4 OS=Squalus acanthias OX=7797 GN=STK4 PE=2 SV=1) HSP 1 Score: 465.307 bits (1196), Expect = 6.040e-159 Identity = 244/473 (51.59%), Postives = 325/473 (68.71%), Query Frame = 3
Query: 18 MEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIRENRQHEEDT-IQSRGSVTEEERTTDNGTMVRCSGDTATSLSSES-------SMIVRDSLSSSVEAPTMLINATDDDSEAGGDTLTEQPHKSNKSPSQFAHQKKLQENGVKESAAQSPCGPLNP--NAFVNVEEIYRNLETKSYNELQQLLSRIDSDLQAELNNLEIRYLHKRQPILDAISEKSK 1406
++KL +D L K+P EVF + KLG+GSYGSV+KA HK++G VA K VPV+S+L +I+KEISIMQQC S ++V+YYGS++ + DLWIVMEYCGAGSVSD++R+RNKT E+EIA ILQ +LKGLEY+H ++KIHRDIKAGNILL EG+AKLADFGVAGQL+DT+AKRNTVIGTP+WMAPEVIQEIGY+ ADIWSLGI+AIEMA+GKPPYADIHPMRA+FMIP+ PPPT P +W+ F +F+ QCLVKNP+QR +A+QLL + FI NA L I EI+ RQ E+ + EE D+GTMVR S + ++ + S +MI DS + + TM+IN+ +D+ + E +S S ++ QK+ +EN + ++ N N V + + +L++ S ELQ+ L+ +D ++ E+ + RY KRQPILDAI K +
Sbjct: 16 LKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDLIRIRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNNEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGISAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWTDEFTDFVKQCLVKNPEQRAAATQLLQH-PFIKNAKPVSILRDLITDMMEIKLKRQEEQQRDLDQDDEENSEEDDMDSGTMVRASAEDTGTMRAASTLSDGARTMIEHDSSTLDSQMGTMVINSGEDEEDGTMKRKEETIQQSKPSFLEYFEQKE-KENQANSHSNRNAQALQNSSDNWKVPQDGDFESLKSWSVEELQRRLASLDPTMEQEIEEIRQRYQAKRQPILDAIDAKKR 486
BLAST of HPO vs. UniProt/SwissProt
Match: sp|A4K2W5|STK4_AOTNA (Serine/threonine-protein kinase 4 OS=Aotus nancymaae OX=37293 GN=STK4 PE=3 SV=1) HSP 1 Score: 463.766 bits (1192), Expect = 2.055e-158 Identity = 243/472 (51.48%), Postives = 328/472 (69.49%), Query Frame = 3
Query: 18 MEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIRENRQH-EEDTIQSRGSVTEEERTTDNGTMVRCSGD------TATSLSSESSMIVRDSLSSSVEAPTMLINATDDDSEAGGDTLTEQPHKSNKSPSQFAHQKKLQENGVKESAAQSPCGPLNPNAFVNVEE--IYRNLETKSYNELQQLLSRIDSDLQAELNNLEIRYLHKRQPILDAISEKSK 1406
++KL +D L K+P EVF + KLG+GSYGSVYKA HK+ G VA K VPV+S+L +I+KEISIMQQC S ++V+YYGS++ + DLWIVMEYCGAGSVSDI+RLRNKT E+EIA ILQ +LKGLEY+H ++KIHRDIKAGNILL EG+AKLADFGVAGQL+DT+AKRNTVIGTP+WMAPEVIQEIGY+ ADIWSLGITAIEMA+GKPPYADIHPMRA+FMIP+ PPPT P +WS +F +F+ QCLVK+P+QR +A+QLL + F+ +A L I +A +++ RQ ++ + EE D+GTMVR GD A++++ ++ ++ + + TM+INA D++ E E + S ++ QK+ +EN + S +S GPL ++ V + Y L++ + +LQ+ L +D ++ E+ + +Y KRQPILDAI K +
Sbjct: 14 LKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSHHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQH-PFVKSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKE-KENQIN-SFGKSIPGPLQNSSDWKVPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAKKR 482
BLAST of HPO vs. TrEMBL
Match: W8E711 (HPO OS=Schmidtea mediterranea OX=79327 GN=hpo PE=2 SV=1) HSP 1 Score: 980.319 bits (2533), Expect = 0.000e+0 Identity = 472/472 (100.00%), Postives = 472/472 (100.00%), Query Frame = 3
Query: 18 MEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIRENRQHEEDTIQSRGSVTEEERTTDNGTMVRCSGDTATSLSSESSMIVRDSLSSSVEAPTMLINATDDDSEAGGDTLTEQPHKSNKSPSQFAHQKKLQENGVKESAAQSPCGPLNPNAFVNVEEIYRNLETKSYNELQQLLSRIDSDLQAELNNLEIRYLHKRQPILDAISEKSKPIAASVNSK 1433
MEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIRENRQHEEDTIQSRGSVTEEERTTDNGTMVRCSGDTATSLSSESSMIVRDSLSSSVEAPTMLINATDDDSEAGGDTLTEQPHKSNKSPSQFAHQKKLQENGVKESAAQSPCGPLNPNAFVNVEEIYRNLETKSYNELQQLLSRIDSDLQAELNNLEIRYLHKRQPILDAISEKSKPIAASVNSK
Sbjct: 1 MEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIRENRQHEEDTIQSRGSVTEEERTTDNGTMVRCSGDTATSLSSESSMIVRDSLSSSVEAPTMLINATDDDSEAGGDTLTEQPHKSNKSPSQFAHQKKLQENGVKESAAQSPCGPLNPNAFVNVEEIYRNLETKSYNELQQLLSRIDSDLQAELNNLEIRYLHKRQPILDAISEKSKPIAASVNSK 472
BLAST of HPO vs. TrEMBL
Match: W5P3R1 (Serine/threonine kinase 4 OS=Ovis aries OX=9940 GN=STK4 PE=4 SV=1) HSP 1 Score: 472.241 bits (1214), Expect = 3.018e-159 Identity = 246/472 (52.12%), Postives = 328/472 (69.49%), Query Frame = 3
Query: 18 MEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIRENRQH-EEDTIQSRGSVTEEERTTDNGTMVRCSGD------TATSLSSESSMIVRDSLSSSVEAPTMLINATDDDSEAGGDTLTEQPHKSNKSPSQFAHQKKLQENGVKESAAQSPCGPLNPNAFVNVEE--IYRNLETKSYNELQQLLSRIDSDLQAELNNLEIRYLHKRQPILDAISEKSK 1406
++KL +D L K+P EVF + KLG+GSYGSVYKA HK+ G VA K VPV+S+L +I+KEISIMQQC S ++V+YYGS++ + DLWIVMEYCGAGSVSDI+RLRNKT E+EIA ILQ +LKGLEY+H ++KIHRDIKAGNILL EG+AKLADFGVAGQL+DT+AKRNTVIGTP+WMAPEVIQEIGY+ ADIWSLGITAIEMA+GKPPYADIHPMRA+FMIP+ PPPT P +WS SF++F+ QCLVK+P+QR +A+QLL F+ NA L I +A +++ RQ ++ + EE D+GTMVR +GD A+S+S ++ ++ + + TM+IN D++ E E + S ++ QK+ +EN + S +S GPL ++ V + Y L++ + +LQ+ L +D ++ E+ + +Y KRQPILDAI K +
Sbjct: 14 LKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDSFMDFVKQCLVKSPEQRATATQLLQKHPFVKNAKGVSILRDLINEAMDVKLKRQEAQQREVDQDEEENSEEDELDSGTMVRAAGDEMGTVRVASSMSDGANTMIEHDDTLPSQLGTMVINTEDEEEEGTMKRRDETMQPARPSFLEYFEQKE-KENQIN-SFGKSVPGPLQNSSDWKVPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAKKR 483
BLAST of HPO vs. TrEMBL
Match: L8I5Z4 (Serine/threonine-protein kinase 4 (Fragment) OS=Bos mutus OX=72004 GN=M91_07783 PE=4 SV=1) HSP 1 Score: 469.159 bits (1206), Expect = 3.400e-158 Identity = 245/472 (51.91%), Postives = 329/472 (69.70%), Query Frame = 3
Query: 18 MEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIRENRQH-EEDTIQSRGSVTEEERTTDNGTMVRCSGD------TATSLSSESSMIVRDSLSSSVEAPTMLINATDDDSEAGGDTLTEQPHKSNKSPSQFAHQKKLQENGVKESAAQSPCGPLNPNAFVNVEE--IYRNLETKSYNELQQLLSRIDSDLQAELNNLEIRYLHKRQPILDAISEKSK 1406
++KL +D L K+P EVF + KLG+GSYGSVYKA HK+ G VA K VPV+S+L +I+KEISIMQQC S ++V+YYGS++ + DLWIVMEYCGAGSVSDI+RLRNKT E+EIA ILQ +LKGLEY+H ++KIHRDIKAGNILL EG+AKLADFGVAGQL+DT+AKRNTVIGTP+WMAPEVIQEIGY+ ADIWSLGITAIEMA+GKPPYADIHPMRA+FMIP+ PPPT P +WS SF++F+ QCLVK+P+QR +A+QLL + F+ +A L I +A +++ RQ ++ + EE D+GTMVR +GD A+S+S ++ ++ + + TM+IN D++ E E + S ++ QK+ +EN + S +S GPL ++ V + Y L++ + +LQ+ L +D ++ E+ + +Y KRQPILDAI K +
Sbjct: 3 LKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDSFMDFVKQCLVKSPEQRATATQLLQH-PFVKSAKGVSILRDLINEAMDVKLKRQEAQQREVDQEEEENSEEDELDSGTMVRAAGDEMGTVRVASSMSDGANTMIEHDDTLPSQLGTMVINTEDEEEEGTMKRRDETMQPARPSFLEYFEQKE-KENQIN-SFGKSVPGPLQNSSDWKVPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAKKR 471
BLAST of HPO vs. TrEMBL
Match: A0A452VNN2 (Serine/threonine kinase 4 OS=Ursus maritimus OX=29073 GN=STK4 PE=4 SV=1) HSP 1 Score: 469.544 bits (1207), Expect = 3.581e-158 Identity = 246/473 (52.01%), Postives = 331/473 (69.98%), Query Frame = 3
Query: 15 MMEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIRENRQH-EEDTIQSRGSVTEEERTTDNGTMVRCSGD------TATSLSSESSMIVRDSLSSSVEAPTMLINATDDDSEAGGDTLTEQPHKSNKSPSQFAHQKKLQENGVKESAAQSPCGPLNPNAFVNVEE--IYRNLETKSYNELQQLLSRIDSDLQAELNNLEIRYLHKRQPILDAISEKSK 1406
+++KL +D L K+P EVF + KLG+GSYGSVYKA HK+ G VA K VPV+S+L +I+KEISIMQQC S ++V+YYGS++ + DLWIVMEYCGAGSVSDI+RLRNKT E+EIA ILQ +LKGLEY+H ++KIHRDIKAGNILL EG+AKLADFGVAGQL+DT+AKRNTVIGTP+WMAPEVIQEIGY+ ADIWSLGITAIEMA+GKPPYADIHPMRA+FMIP+ PPPT P +WS +F++F+ QCLVK+P+QR +A+QLL + F+ +A L I +A +++ RQ ++ + EE D+GTMVR +GD A+++S +S ++ + + TM+INA D++ E E + S ++ QK+ +EN + S QS GPL ++ V + Y L++ + +LQ+ L +D ++ E+ + +Y KRQPILDAI K +
Sbjct: 9 ILKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFMDFVKQCLVKSPEQRATATQLLQH-PFVKSAKGVSILRDLINEAMDVKLKRQEAQQREVDQDDEENSEEDEMDSGTMVRAAGDEMGTVRVASTVSDGASTMIEHGDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKE-KENQIN-SFGQSVPGPLRNSSDWKVPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAKKR 478
BLAST of HPO vs. TrEMBL
Match: A0A2Y9GZS1 (serine/threonine-protein kinase 4 OS=Neomonachus schauinslandi OX=29088 GN=STK4 PE=4 SV=1) HSP 1 Score: 469.544 bits (1207), Expect = 3.597e-158 Identity = 246/472 (52.12%), Postives = 330/472 (69.92%), Query Frame = 3
Query: 18 MEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIRENRQH-EEDTIQSRGSVTEEERTTDNGTMVRCSGD------TATSLSSESSMIVRDSLSSSVEAPTMLINATDDDSEAGGDTLTEQPHKSNKSPSQFAHQKKLQENGVKESAAQSPCGPLNPNAFVNVEE--IYRNLETKSYNELQQLLSRIDSDLQAELNNLEIRYLHKRQPILDAISEKSK 1406
++KL +D L K+P EVF + KLG+GSYGSVYKA HK+ G VA K VPV+S+L +I+KEISIMQQC S ++V+YYGS++ + DLWIVMEYCGAGSVSDI+RLRNKT E+EIA ILQ +LKGLEY+H ++KIHRDIKAGNILL EG+AKLADFGVAGQL+DT+AKRNTVIGTP+WMAPEVIQEIGY+ ADIWSLGITAIEMA+GKPPYADIHPMRA+FMIP+ PPPT P +WS +F++F+ QCLVK+P+QR +A+QLL + F+ +A L I +A +++ RQ ++ + EE D+GTMVR +GD A+++S +S ++ + + TM+INA D++ E E + S ++ QK+ +EN + S QS GPL ++ V + Y L++ + +LQ+ L +D ++ E+ + +Y KRQPILDAI K +
Sbjct: 14 LKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFMDFVKQCLVKSPEQRATATQLLQH-PFVKSAKGVSILRDLINEAMDVKLKRQEAQQREVDQDDEENSEEDEMDSGTMVRAAGDEMGTVRVASTVSDGASTMIEHGDTLPSQLGTMVINAEDEEEEGTMKRREETMQPAKPSFLEYFEQKE-KENQIN-SFGQSVPGPLRSSSDWKVPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAKKR 482
BLAST of HPO vs. Ensembl Cavefish
Match: stk3 (serine/threonine kinase 3 [Source:NCBI gene;Acc:103027492]) HSP 1 Score: 444.121 bits (1141), Expect = 1.875e-151 Identity = 239/480 (49.79%), Postives = 320/480 (66.67%), Query Frame = 3
Query: 18 MEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIRENRQHEEDTIQSRGSVTEEERTTDNG--TMVRCSGDTATSLSSES-------SMIVRDSLSSSVEAPTMLINATDDDSEAGGDTLTEQPHKSN-KSPSQFAHQKKLQENGVKESAAQSPCGP--LNPNAFVNVEEI-----YRNLETKSYNELQQLLSRIDSDLQAELNNLEIRYLHKRQPILDAISEKSK 1406
++KL +D L K+P EVF + KLG+GSYGSV+KA HK++G VA K VPV+S+L +I+KEISIMQQC S Y+V+YYGS++ + DLWIVMEYCGAGSVSDI+RLRNKT E+EIA IL+ +LKGLEY+H ++KIHRDIKAGNILL EG+AKLADFGVAGQL+DT+AKRNTVIGTP+WMAPEVIQEIGY+ ADIWSLGIT+IEMA+GKPPYADIHPMRA+FMIP+ PPPT P +WS F +F+ +CLVKNP+QR +A+QLL + FI +A L I +A +++ RQ E+ E + TMV+ ++A ++ + +MI S + TM+IN+ D+D + ++ P + PS + K N +ES + P ++ AF + ++ + L+ + ELQ LS +D ++ E+ L RY KRQPILDA+ K +
Sbjct: 10 LKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQH-PFITSAKPVSILRDLITEAMDMKAKRQQEQQRELEEEDENSVEEEVEVDSHTMVKSGSESAGTMRATGTMSDGAQTMIEHGSTMLESDLGTMVINSDDEDEDEDVGSMRRNPTAPQAQRPSFMDYFDKQDSNKAQESYNHNQQDPYLIHKTAFPDNWKVPQDGDFDFLKNLEFEELQMRLSALDPMMEREIEELRQRYTAKRQPILDAMDAKKR 488
BLAST of HPO vs. Ensembl Cavefish
Match: STK4 (serine/threonine kinase 4 [Source:HGNC Symbol;Acc:HGNC:11408]) HSP 1 Score: 438.343 bits (1126), Expect = 9.282e-150 Identity = 236/467 (50.54%), Postives = 305/467 (65.31%), Query Frame = 3
Query: 18 MEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASS----PDHLIATIKQANEIRENRQHEEDTIQSRGSVTEEERTTDNGTMVRCSGDTATSLSSESSMIVRDSLSSSVEAPTMLINATDDDSEAGGDTLTEQPHKSNKSPSQFAHQKKLQENGVKESAAQSPCGPLNPNAFVNVEEIYRNLETKSYNELQQLLSRIDSDLQAELNNLEIRYLHKRQPILDAISEKSK 1406
++KL +D L K+P EVF + KLG+GSYGSV+KA +K+ G VA K VPV+S+L +I+KEISIMQQC S ++V+YYGS++ + DLWIVMEYCGAGSVSDI+R RNKT E+EIA ILQ +LKGLEY+H ++KIHRDIKAGNILL EG AKLADFGVAGQL+DT+AKRNTVIGTP+WMAPEVIQEIGY+ ADIWSLGITAIEMA+GKPPYADIHPMRA+FMIP+ PPPT NP WS F +F++QCLVKNP+ R +A+QLL F+ I+ + Q +R +D GT VR G S+ +MI D S + TM+IN+ D+D AG T + H+ P++ + + ++ KE A N N+ E + + S EL++ L+ +D ++ E+ + RY KRQPILDAI K +
Sbjct: 17 LKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAHYKETGEIVAIKQVPVESDLQEIIKEISIMQQCNSPHVVRYYGSYFKNSDLWIVMEYCGAGSVSDIIRQRNKTLAEDEIAAILQSTLKGLEYLHFMRKIHRDIKAGNILLNSEGQAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRNPDQWSEPFRDFVSQCLVKNPENRATATQLLQVFIFVYFGLYLYLFLHFCISYMDQGTMVRAG-------------------ASDMGT-VRAVGLLG---STSGTMIEHDGTMES-QLGTMVINSDDEDETAG----TMKHHEETMQPAKPSFLEYFEQ---KEKEANKNSD--NDNSKAPAEADMELMRSWSVEELKRRLASLDPQMEQEIEEIRQRYQTKRQPILDAIEAKKR 450
BLAST of HPO vs. Ensembl Cavefish
Match: stk25b (serine/threonine-protein kinase 25-like [Source:NCBI gene;Acc:103039280]) HSP 1 Score: 273.478 bits (698), Expect = 3.338e-86 Identity = 132/263 (50.19%), Postives = 179/263 (68.06%), Query Frame = 3
Query: 27 LLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIV---KEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLL 806
L + + +P E F + ++GKGS+G VYK + + VA K++ ++ +I +EI+++ QC S ++ +YYGS+ LWI+MEY G GS D+ LR E IA IL+ LKGLEY+H +KIHRDIKA N+LL+E+G+ KLADFGVAGQL+DT KRNT +GTP+WMAPEVI++ Y + ADIWSLGITAIE+A G+PP +D+HPMR LF+IP PPPTL +S F F+ CL K+P RP+A +LL
Sbjct: 11 LFSTNARLDPEEYFTKQERIGKGSFGEVYKGINNRTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPFVTKYYGSYLKGTKLWIIMEYLGGGSALDL--LRPGPLEETYIATILREILKGLEYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNPPPTL--EGSYSKPFKEFVEACLNKDPRFRPTAKELL 269
BLAST of HPO vs. Ensembl Cavefish
Match: stk25b (serine/threonine-protein kinase 25-like [Source:NCBI gene;Acc:103039280]) HSP 1 Score: 273.478 bits (698), Expect = 6.050e-86 Identity = 131/255 (51.37%), Postives = 176/255 (69.02%), Query Frame = 3
Query: 51 EPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIV---KEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLL 806
+P E F + ++GKGS+G VYK + + VA K++ ++ +I +EI+++ QC S ++ +YYGS+ LWI+MEY G GS D+ LR E IA IL+ LKGLEY+H +KIHRDIKA N+LL+E+G+ KLADFGVAGQL+DT KRNT +GTP+WMAPEVI++ Y + ADIWSLGITAIE+A G+PP +D+HPMR LF+IP PPPTL +S F F+ CL K+P RP+A +LL
Sbjct: 15 DPEEYFTKQERIGKGSFGEVYKGINNRTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPFVTKYYGSYLKGTKLWIIMEYLGGGSALDL--LRPGPLEETYIATILREILKGLEYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNPPPTL--EGSYSKPFKEFVEACLNKDPRFRPTAKELL 265
BLAST of HPO vs. Ensembl Cavefish
Match: stk26 (serine/threonine kinase 26 [Source:NCBI gene;Acc:103024322]) HSP 1 Score: 265.003 bits (676), Expect = 5.757e-83 Identity = 133/274 (48.54%), Postives = 179/274 (65.33%), Query Frame = 3
Query: 51 EPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIV---KEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATI 863
+P E+F ++GKGS+G V+K ++ VA K + ++ +I +EI+++ QC S ++ +YYGS+ LWI+MEY G GS D+ LR +E +IA +L+ LKGL+Y+H KKIHRDIKA N+LL+E G KLADFGVAGQL+DT KR T +GTP+WMAPEVIQ+ Y ADIWSLGITAIE+A G+PP +D+HPMR LF IP PPTL +S SF F+ CL K+P RP+A +LL + + NA +L I
Sbjct: 19 DPEELFTKLERIGKGSFGEVFKGIDRRTQNVVAIKTIDLEEAEDEIEDIQQEITVLSQCDSPHVTKYYGSYLKGSKLWIIMEYLGGGSALDL--LRAGPFDECQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSESGEVKLADFGVAGQLTDTQIKRETFVGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFHIPKNTPPTLNGD--FSKSFKEFVDSCLNKDPTFRPTAKELLKHKFIVKNAKKTSYLTELI 288
BLAST of HPO vs. Ensembl Sea Lamprey
Match: stk25a (serine/threonine kinase 25a [Source:ZFIN;Acc:ZDB-GENE-041010-92]) HSP 1 Score: 259.996 bits (663), Expect = 2.158e-81 Identity = 125/257 (48.64%), Postives = 176/257 (68.48%), Query Frame = 3
Query: 51 EPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIV---KEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIK--AGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLL 806
+P E+F + ++GKGS+G V+K + VA K++ ++ +I +EI+++ QC S Y+ Y+GS+ LWI+MEY G GS D+ ++ E +IA IL+ LKGL+Y+H +KIHRDIK A N+LL+E+G+ KLADFGVAGQL+DT KRNT +GTP+WMAPEVI++ Y + ADIWSLGITAIE+A G+PP +++HPMR LF+IP PPTL +S +F F+ CL K+P RP+A +LL
Sbjct: 21 DPEELFTKQERIGKGSFGEVFKGIDNRTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTHYFGSYLKGTKLWIIMEYLGGGSALDL--IKPGPLEEHQIATILREILKGLDYLHSERKIHRDIKGPAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSELHPMRVLFLIPKNNPPTL--EGNYSKAFKEFVDSCLNKDPQFRPTAKELL 273
BLAST of HPO vs. Ensembl Sea Lamprey
Match: MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6865]) HSP 1 Score: 250.751 bits (639), Expect = 5.539e-74 Identity = 120/256 (46.88%), Postives = 174/256 (67.97%), Query Frame = 3
Query: 60 EVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVD--SELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVI---QEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQ--PPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLL 806
E F++ +LG G+YG V+KA++ + G VA K++ ++ + S I +EI +M++CK IV YYGS+ LWI ME+CG GS+ DI + E +IA + + +L+GL Y+H K+HRDIK NILLT++G+ KLADFGV+ Q++ T+AKR + IGTPYWMAPEV ++ GY++ D+W++GITAIE+A+ +PP D+HPMRALF++ PP L + WSP F NFI L KNP +RP+A ++L
Sbjct: 12 EDFELAERLGSGTYGDVHKARNVQTGELVAIKIIKLEPGDDFSVIQQEIVMMKECKHTNIVAYYGSYLRHDKLWICMEHCGGGSLQDIYHVTGPL-TERQIAYVTRETLQGLAYLHSEGKMHRDIKGANILLTDDGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNHQCDVWAVGITAIELAELQPPMFDLHPMRALFLMSKSGFQPPKLRDKQKWSPVFHNFIKMALTKNPKKRPTAEKML 266
BLAST of HPO vs. Ensembl Sea Lamprey
Match: myo3a (myosin IIIA [Source:ZFIN;Acc:ZDB-GENE-041026-4]) HSP 1 Score: 248.054 bits (632), Expect = 1.112e-71 Identity = 131/286 (45.80%), Postives = 182/286 (63.64%), Query Frame = 3
Query: 15 MMEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAK-LVPVDS-ELS------DIVKEISIMQQC-KSDYIVQYYGSFY-----DSHDLWIVMEYCGAGSVSDIMR---LRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVI---QEIGYHY--SADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLL 806
M KL+ + K+PS+ +++ +GKG+YG VYKA +K+G A K L PV++ E S +I E SI+ + IV+++G +Y + LWIV+E C GSV+D+++ R + + IA IL+G+L GL ++H IHRDIK NILLT +G +L DFGV+ Q+S T +RNT +GTP+WMAPEVI Q++ Y Y D+WS+GITAIE+ DG PP ++HPMRALF IP PPPTL P +W P F FI QCLVK+ ++R + SQLL
Sbjct: 7 MSTKLIKFEQLKDPSDTWELVETIGKGTYGKVYKATSRKDGSKAAVKTLDPVNNLETSNQDIDEEIEAEYSILTSLPEHPNIVRFFGMYYQKDGVNGDQLWIVLELCNGGSVTDLVKGQLKRGERMDVMLIAYILRGALLGLNHLHSHNIIHRDIKGNNILLTTDGGIRLVDFGVSAQVSKTRVERNTAVGTPFWMAPEVIACEQQLDYMYDRRCDVWSMGITAIELGDGDPPLYELHPMRALFKIPRNPPPTLKQPELWPPLFNEFIAQCLVKDFERRATVSQLL 292
BLAST of HPO vs. Ensembl Sea Lamprey
Match: slka (STE20-like kinase a [Source:ZFIN;Acc:ZDB-GENE-050411-66]) HSP 1 Score: 242.276 bits (617), Expect = 8.112e-70 Identity = 122/282 (43.26%), Postives = 176/282 (62.41%), Query Frame = 3
Query: 51 EPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSE--LSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVI-----QEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQAN 875
+P+E++ + +LG G++G VYKA++K++G AAK++ SE L D + EI I+ C IV +FY + LWI +E+C G+V IM + E +I ++ + L+ L Y+H + IHRD+KAGNILLT EG+ KLADFGV+ + + TL +R++ IGTPYWMAPEV+ ++ Y Y ADIWSLGIT IE+A +PP +++PMR + I PP+L PS WS F +F+ +CL KNP+ R +A QLL + FI S L I +A
Sbjct: 28 DPAELWSVIGELGDGAFGKVYKAQNKESGVLAAAKVIETKSEEELEDYMVEIEILALCDHPNIVGLLNAFYYENKLWIFIEFCPGGAVDAIMLELERGLAEPQIRVVCKQMLEALNYLHTHRIIHRDLKAGNILLTFEGDVKLADFGVSAKNTRTLQRRDSFIGTPYWMAPEVVMCETMKDAPYDYKADIWSLGITLIELAQMEPPNHELNPMRVMLKIAKNDPPSLSFPSKWSAEFTDFLKKCLDKNPETRWNALQLLQHS-FISGVDSNKPLRELIAEAK 308
BLAST of HPO vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010511.1 (pep scaffold:Pmarinus_7.0:GL476756:358747:414819:1 gene:ENSPMAG00000009510.1 transcript:ENSPMAT00000010511.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 225.328 bits (573), Expect = 9.557e-65 Identity = 121/275 (44.00%), Postives = 175/275 (63.64%), Query Frame = 3
Query: 111 YKAKHKKNGFTVAAKLVPVDS--ELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVI---QEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQ--PPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFII---NASSPDHLIATIKQANEIRENRQHEE 905
++A++ ++G A K++ ++S + + I +EI +MQ+C+ IV Y+GS+ LWI MEYCG GS+ DI + +E +IA + + +LKGL Y+H K+HRDIK NILLT+ G KLADFGV+ Q++ T+AKR + IGTPYWMAPEV ++ GY+ D+W++GITAIE+A+ +PP D+HPMRALF++ PP L + WS F NFI Q L+KNP +RP+A +LL + F+I N S L+ +K R EE
Sbjct: 1 FQARNVQSGALSAIKVIKLESGDDFTVIQQEIIMMQECQHINIVAYFGSYLRWDKLWICMEYCGGGSLQDIYHVTGPL-SERQIAYVSRETLKGLAYLHSKCKMHRDIKGANILLTDHGEVKLADFGVSAQITATIAKRMSFIGTPYWMAPEVAAVERKGGYNQQCDVWAVGITAIELAELQPPMFDLHPMRALFLMSKSNFQPPRLKDKVKWSGIFHNFIKQSLIKNPKKRPTADKLLQD-PFVIQPLNRSLATELLDQMKSPAPPRNFYDDEE 273
BLAST of HPO vs. Ensembl Yeast
Match: SPS1 (Putative protein serine/threonine kinase; localizes to the nucleus and cytoplasm; required for efficient spore packaging, prospore membrane development and closure and localization of enzymes involved in spore wall synthesis; interacts with and required for Ssp1p phosphorylation and turnover; member of the GCKIII subfamily of STE20 kinases; multiply phosphorylated on S/T residues; interacts with 14-3-3 proteins, Bmh1p and Bmh2p; expressed at the end of meiosis [Source:SGD;Acc:S000002931]) HSP 1 Score: 223.402 bits (568), Expect = 5.051e-67 Identity = 117/267 (43.82%), Postives = 167/267 (62.55%), Query Frame = 3
Query: 54 PSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPV---DSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIM-RLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVI--QEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINAS 836
PS+++ I+S +G+G++G VYKA + VA K+V + D ++ + +EI + + KS I Y + + +WIVMEYCG GS SD++ R EE+++ I+ GL+Y+H+ +KIHRDIKA NILL EEG KL DFGV+G + TL KR+T +GTPYWMAPEV+ + GY+ ADIWSLGIT E+ G PP + PM+ + +P + PP L P +S + +F+ CLVK P RPSA LL+ EF+ N +
Sbjct: 14 PSKLYSIQSCIGRGNFGDVYKAVDRVTQEIVAIKVVNLEHSDEDIELLAQEIFFLAELKSPLITNYIATMLEDVSMWIVMEYCGGGSCSDLLKRSYVNGLPEEKVSFIIHEVTLGLKYLHEQRKIHRDIKAANILLNEEGMVKLGDFGVSGHIRSTL-KRDTFVGTPYWMAPEVVCCEVDGYNEKADIWSLGITTYELLKGLPPLSKYDPMKVMTNLPKRKPPKLQGP--FSDAAKDFVAGCLVKTPADRPSAYN-LLSFEFVKNIT 276
BLAST of HPO vs. Ensembl Yeast
Match: KIC1 (Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis [Source:SGD;Acc:S000001144]) HSP 1 Score: 211.075 bits (536), Expect = 2.520e-59 Identity = 114/261 (43.68%), Postives = 158/261 (60.54%), Query Frame = 3
Query: 57 SEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDS---ELSDIVKEISIMQQCKS-DYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQE-IGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFI 824
S +F+ +G+G +G VYK + K G A K++ +DS E+ D+ +EI + K I +YYGS+ LWI+ME+C GS+ + LR +E+ I +I++ L L+ IH+ IHRDIKA N+L+T EGN KL DFGVA Q++ T +R T+ GTPYWMAPEVI E + Y DIWSLGIT E+A G PPY D+ +RA+ +I PP L + S +S S FI CL ++P +R SA LL +FI
Sbjct: 20 SSLFKRTEVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQFLASLKQISNITRYYGSYLKDTSLWIIMEHCAGGSLRSL--LRPGKIDEKYIGVIMRELLVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAAQVNQTSLRRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSLGITTYEIATGNPPYCDVEALRAMQLIIKSKPPRLEDRS-YSTSLKEFIALCLDEDPKERLSADD-LLKSKFI 276
BLAST of HPO vs. Ensembl Yeast
Match: STE20 (Cdc42p-activated signal transducing kinase; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p; member of the PAK (p21-activated kinase) family [Source:SGD;Acc:S000000999]) HSP 1 Score: 195.282 bits (495), Expect = 4.018e-54 Identity = 100/254 (39.37%), Postives = 149/254 (58.66%), Query Frame = 3
Query: 51 EPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSD--IVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLL 806
+PS + K+G+G+ G VY A +VA K + ++ + I+ EI +M+ K IV + S+ DLW++MEY GS++D+ + + E +I + + +L GLE++H +HRDIK+ NILL+ EG+ KL DFG Q+++ KR T++GTPYWMAPEV+ Y DIWSLGI IEM +G+PPY + P+RAL++I + P L P S S F+ CL P+ R SA++LL
Sbjct: 615 DPSTKYANLVKIGQGASGGVYTAYEIGTNVSVAIKQMNLEKQPKKELIINEILVMKGSKHPNIVNFIDSYVLKGDLWVIMEYMEGGSLTDV--VTHCILTEGQIGAVCRETLSGLEFLHSKGVLHRDIKSDNILLSMEGDIKLTDFGFCAQINELNLKRTTMVGTPYWMAPEVVSRKEYGPKVDIWSLGIMIIEMIEGEPPYLNETPLRALYLIATNGTPKLKEPENLSSSLKKFLDWCLCVEPEDRASATELL 866
BLAST of HPO vs. Ensembl Yeast
Match: SKM1 (Member of the PAK family of serine/threonine protein kinases; similar to Ste20p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth; SKM1 has a paralog, CLA4, that arose from the whole genome duplication [Source:SGD;Acc:S000005473]) HSP 1 Score: 189.119 bits (479), Expect = 6.215e-53 Identity = 105/299 (35.12%), Postives = 167/299 (55.85%), Query Frame = 3
Query: 54 PSEVFQIESKLGKGSYGSVYKAK-----------------HKKNGFTVAAKLVPVDSELSD--IVKEISIMQQCKSDYIVQYYGSFY-DSHDLWIVMEYCGAGSVSDIMRL--RNKT------CNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIK 866
P FQ+ K G+G+ G+VY +K H+ G VA K + + + I+ E+ +M + + IV + ++ D +LW++MEY G ++DI+ R+ T NE ++A I++ + +GL+++H K IHRDIK+ NILL +G K+ DFG +L++ +KR T++GTPYWMAPE++ + GY D+WSLGI IEM +G+PPY + P++AL++I + P L +P S F+ CL N + R S + LL EF+ A SP+ L ++K
Sbjct: 356 PRPYFQLVEKAGQGASGAVYLSKRIKLPQENDPRFLKSHCHRVVGERVAIKQIRLSEQPKKQLIMNELLVMNDSRQENIVNFLEAYIIDDEELWVIMEYMEGGCLTDILDAVARSNTGEHSSPLNENQMAYIVKETCQGLKFLHNKKIIHRDIKSDNILLNSQGLVKITDFGFCVELTEKRSKRATMVGTPYWMAPEIVNQKGYDEKVDVWSLGIMLIEMIEGEPPYLNEDPLKALYLIANNGSPKLRHPESVSKQTKQFLDACLQVNVESRASVRK-LLTFEFLSMACSPEQLKVSLK 653
BLAST of HPO vs. Ensembl Yeast
Match: CLA4 (Cdc42p-activated signal transducing kinase; member of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p; CLA4 has a paralog, SKM1, that arose from the whole genome duplication [Source:SGD;Acc:S000005242]) HSP 1 Score: 174.866 bits (442), Expect = 2.739e-47 Identity = 99/299 (33.11%), Postives = 158/299 (52.84%), Query Frame = 3
Query: 15 MMEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAK---------------------HKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHD-LWIVMEYCGAGSVSDIMRLRNKTCN--------EEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEF 821
+M KL + +PS+ F++ K G+G+ GSVY A+ H + + ++ IV EI +M+ + IV + ++ + D LW+VME+ GS++DI + N N E +IA I++ + +GL+++H IHRDIK+ N+LL K+ DFG +L+D +KR T++GTPYWMAPEV+++ Y D+WSLGI IEM +G+PPY + P++AL++I + P L +P S F++ CL + R S +LL + F
Sbjct: 529 IMSKLKKVTVNADPSQCFKVIEKAGQGASGSVYLAERTHIPTESNMIELINNDIDEPHVGDKVAIKQMVLSKQPRKELIVNEILVMKDSRHKNIVNFLEAYLRTDDDLWVVMEFMEGGSLTDI--IENSPTNDNSHSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRARVKITDFGFCARLTDKRSKRATMVGTPYWMAPEVVKQREYDEKIDVWSLGIMTIEMLEGEPPYLNEDPLKALYLIATNGTPKLKHPESLSLEIKRFLSVCLCVDVRYRASTEELLHHGFF 825
BLAST of HPO vs. Ensembl Nematostella
Match: EDO42845 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S0A9]) HSP 1 Score: 404.06 bits (1037), Expect = 8.941e-139 Identity = 187/299 (62.54%), Postives = 239/299 (79.93%), Query Frame = 3
Query: 18 MEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIRENRQHEEDTI 914
+ KL ++ L + P EVF + KLG+GSYGSV+KA HK++G VA K VPVD++L +I+KEIS+MQQC S Y+V+YYGS++ + DLWIVMEYCGAGSVSD+M++RNKT EEEI +L+ +LKGLEY+H +KIHRDIKAGNILL EG+AKLADFGVAGQL+DT+AKRNTVIGTP+WMAPEVIQE+GY ADIWSLGITA+EMA+GKPPYADIHPMRA+FMIP++PPPT +P WS F +F+++CLVKNP++R +A++LL + FI A L + I++A I E +D I
Sbjct: 8 LRKLSEESLTRPPEEVFDVLEKLGEGSYGSVFKAMHKESGQVVAIKQVPVDTDLQEIIKEISMMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDLMKIRNKTLTEEEIKCVLKYTLKGLEYLHLRRKIHRDIKAGNILLNSEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEVGYDCLADIWSLGITAMEMAEGKPPYADIHPMRAIFMIPTKPPPTFRDPGQWSEDFKDFVSKCLVKNPEERATATELLQH-SFIQGAKQISILSSMIQEALTIMEEENARDDEI 305
BLAST of HPO vs. Ensembl Nematostella
Match: EDO31934 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SWI4]) HSP 1 Score: 267.7 bits (683), Expect = 1.222e-84 Identity = 131/285 (45.96%), Postives = 191/285 (67.02%), Query Frame = 3
Query: 42 LQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIV---KEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIRE 887
++ +P ++F ++GKGS+G V+K + VA K++ ++ +I +EI+++ QC S Y+ +Y+GS+ LWI+MEY G GS D+M+ N E IA IL+ LKGL+Y+H KK+HRDIKA N+L++E G+ KLADFGVAGQL+DTL KRNT +GTP+WMAPEVI++ Y ADIWSLGITAIE+A G+PP +D+HPMR LF+IP PP L +S +F F++ CL K+P+ RP+A +LL + FI A +L+ I++ + ++
Sbjct: 3 MKADPEKLFSKLERIGKGSFGEVFKGIDNRTNEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSLYVTKYHGSYLKGTKLWIIMEYLGGGSALDLMKAGN--IEEFYIATILREVLKGLDYLHTEKKLHRDIKAANVLMSETGDVKLADFGVAGQLTDTLNKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNNPPELTGN--FSKAFKEFVSLCLNKDPNDRPTAKELLKH-RFIKTAKKNAYLVELIERHKKWKQ 282
BLAST of HPO vs. Ensembl Nematostella
Match: EDO49047 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RHW1]) HSP 1 Score: 240.35 bits (612), Expect = 4.059e-75 Identity = 126/303 (41.58%), Postives = 182/303 (60.07%), Query Frame = 3
Query: 54 PSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVD--SELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPE---VIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQP--PPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIRENRQHEEDTIQSRGSVTEE 941
P +VF + K+G G+YG V+KA+ G A K+V V+ + I +EI++MQQC+ + I+ Y G++ LWI MEYCG GS+ D+ + C+E +I+ + +LKGL Y+H+ +HRDIK NILLT G KLADFG++ ++++T+ KR + IGTPYWMAPE V + GY DIW++GITAIEMA+ +PP D+HPMRAL++I + PPTL WS +FI L+KNP +RPSA ++L + HL + Q R R+ +E +Q S E+
Sbjct: 14 PDKVFDLIEKVGGGTYGDVFKARVIATGDLAAVKVVKVEPGDDFELIQQEIAMMQQCRHNNIINYIGAYMRRDKLWIGMEYCGGGSIQDVYCVTG-PCSETQISFVTVETLKGLAYLHEKSLMHRDIKGANILLTTNGEVKLADFGISARITETMKKRKSFIGTPYWMAPEMAAVERTGGYDLKCDIWAVGITAIEMAELQPPMFDLHPMRALYIIGKKSFIPPTLKEKDKWSNEMHHFIKVALIKNPKKRPSADKML------THPFCCRHLTKAVLQDLLDRYRRKSQEKNLQPDDSDDEQ 309
BLAST of HPO vs. Ensembl Nematostella
Match: EDO48741 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RIM4]) HSP 1 Score: 253.447 bits (646), Expect = 2.113e-74 Identity = 118/275 (42.91%), Postives = 174/275 (63.27%), Query Frame = 3
Query: 51 EPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPV--DSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVI-----QEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLN---CEFIINASSPD 845
+P+ +++ +LG GS+G VYKA+HK AAK++ V ++EL D + EI I+ +CK +V + +F LW+++E+C G++ D+M + NE EI + + +GL+++H K IHRD+KAGN+LL +GN K+ADFGV+ + TL KR+T IGTPYWMAPEV+ ++ Y Y ADIWS GIT IE+A PP ++HPMR LF IP PPT NP+ WS +F+ C+VKNPD R SA++++ + +F N + D
Sbjct: 17 DPNSNWELVGELGDGSFGKVYKAQHKTESSLSAAKIIIVNDENELEDFMVEIDILSECKHKNLVGLFETFLHDGKLWMMLEFCSGGALDDLMLELERGLNEPEIRAVTRQLFEGLQFLHNHKVIHRDLKAGNLLLASDGNVKMADFGVSAKNKKTLQKRSTFIGTPYWMAPEVVVTETYKDDPYDYKADIWSAGITLIELAQMVPPNHNMHPMRVLFKIPKSDPPTFDNPNKWSNDLNDFLASCVVKNPDMRASATEMIKHPFIADFTDNKALKD 291
BLAST of HPO vs. Ensembl Nematostella
Match: EDO40961 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S5T6]) HSP 1 Score: 236.884 bits (603), Expect = 9.356e-74 Identity = 130/292 (44.52%), Postives = 182/292 (62.33%), Query Frame = 3
Query: 30 LDD-DLQ--KEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVK-EISIMQQCKSDY-IVQYYGSFYDS------HDLWIVMEYCGAGSVSDIMRL-RNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQ-----EIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLI 854
LDD DL K+P+ +F + +G G+YG V+K +HK+ G A K++ V + + +K EI+++++ + I YYG+F LW+VME+CGAGSV+D+++ RNK EE I+ I + L G+ ++H IHRDIK N+LLTE KL DFGV+ QL T+ +RNT IGTPYWMAPEVI + Y D+WS+GITAIEMA+ +PP D+HPMRALF+IP PP L + WS F +F+ CL+K+ RP+A QLL + EFI + S + I
Sbjct: 5 LDDIDLAALKDPAGIFDLVEVVGNGTYGQVHKGRHKRTGQLTAIKIMDVTEDEEEEIKLEINVLRKFSNHRNIATYYGAFIKKSLQGQDDQLWLVMEFCGAGSVTDLVKTARNKALKEEWISYICREVLNGVSHLHMNHVIHRDIKGQNVLLTESAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACDEQPDATYDNRCDMWSIGITAIEMAESQPPLCDMHPMRALFLIPRSDPPKLKSKKSWSKRFHHFVNTCLIKDYQHRPTADQLLQH-EFIKDVRSSERKI 295
BLAST of HPO vs. Ensembl Medaka
Match: ENSORLT00000024938.2 (serine/threonine-protein kinase 4 [Source:NCBI gene;Acc:101175466]) HSP 1 Score: 451.825 bits (1161), Expect = 1.768e-154 Identity = 241/485 (49.69%), Postives = 323/485 (66.60%), Query Frame = 3
Query: 18 MEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIRENRQHE--------------EDTIQSRGSVTEEERTTDNGTMVRCSGDTATSLSSESSMIV--RDSLSSSVEAPTMLINATDDDSEAGGDTLTEQPHKSNKSPS--QFAHQKKLQENGVKESAAQSPCGPLNPNAFVN----VEEIYRNLETKSYNELQQLLSRIDSDLQAELNNLEIRYLHKRQPILDAISEKSK 1406
++KL +D L K+P EVF + KLG+GSYG V+KA +K+ G VA K VPV+S+L +I+KEISIMQQC S ++V+YYGS++ + DLWIVMEYCGAGSVSDI+R+RNKT +EEEIA ++ +LKGLEY+H ++KIHRDIKAGNILL EG AKLADFGVAGQL+DT+AKRNTVIGTP+WMAPEVIQEIGY+ ADIWSLGITAIEMA+GKPPYADIHPMRA+FMIP+ PPPT NP +WS +F +F++QCLVKNP+ R +A+QLL + FI +A L + I A EI+ +Q E ++ +G++ T D+GT +R +G A SLS ++ D+ + + TM+IN+ ++D E G PS ++ QK+ KE+ Q+ G N N ++ + T S EL++ L+ +D ++ E+ + RY KRQPILDAI K +
Sbjct: 17 LKKLSEDSLTKQPEEVFDVLEKLGEGSYGCVFKANYKETGEIVAIKQVPVESDLQEIIKEISIMQQCNSPHVVRYYGSYFKNSDLWIVMEYCGAGSVSDIIRIRNKTLSEEEIATVVHSTLKGLEYLHFMRKIHRDIKAGNILLNAEGQAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRNPDLWSENFRDFVSQCLVKNPENRATATQLLQH-PFIKSAKPNSVLKSMITDAMEIKLKKQEEALQREQEAEDEDNSDEDEVDQGTMV-RAGTGDSGT-IRAAGSLARSLSDTCRTMIEHEDTGTMQSQLGTMVINSDEEDEEECGTMKRRDETMQPVKPSFLEYFEQKE------KEANIQNDGGRKGENHADNRKLPLDGDLEGVMTWSVEELRKRLASLDPQMEQEIEEIRQRYQAKRQPILDAIQAKKR 492
BLAST of HPO vs. Ensembl Medaka
Match: stk3 (serine/threonine-protein kinase 3 [Source:NCBI gene;Acc:101155570]) HSP 1 Score: 441.039 bits (1133), Expect = 3.213e-150 Identity = 236/485 (48.66%), Postives = 321/485 (66.19%), Query Frame = 3
Query: 18 MEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIR-ENRQHEEDTIQSRGSVTEEERTTDNGTMVRCSGDTATSLSSESSM------IVRDSLSSSVEAPTMLINATDDDSEAGGDTLTEQPHKSNKSPSQF--------AHQKKLQENGVKESAAQSPCG--PLNPNAFVNVEEI-----YRNLETKSYNELQQLLSRIDSDLQAELNNLEIRYLHKRQPILDAISEKSK 1406
++KL +D L K+P EVF + KLG+GSYGSV+KA HK++G VA K VPV+S+L +I+KEISIMQQC S Y+V+YYGS++ + DLWIVMEYCGAGSVSDI+RLRNKT E+EIA IL+ +LKGLEY+H ++KIHRDIKAGNILL EG+AKLADFGVAGQL+DT+AKRNTVIGTP+WMAPEVIQEIGY+ ADIWSLGIT+IEMA+GKPPYADIHPMRA+FMIP+ PPPT P +WS F +F+ +CLVKNP+QR +A+QLL + FI A L I +A E++ + +Q ++ ++ +EEE D+ TMV+ + A ++ + +M ++ + + TM+IN D + ++ P F +++ Q+ + Q P G + N F + ++ + L+ + ELQ LS +D ++ E+ L RY KRQPILDA+ K +
Sbjct: 11 LKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQH-PFISQAKPVTILRDLITEAMEMKAKRQQEQQRELEEEEDNSEEETEVDSHTMVKSGSEGAGTMRATGTMSDGAQTMIEHGTTILDDLGTMVINTDDKEEHEDHGSMRRNPTAQQPIRPAFMDYFDKQDSNKATQQQENYNHNQLQEPSGYHIQSKNVFPDNWKVPQDGDFDFLKNLDFEELQLRLSALDPMMEREIEELRQRYTAKRQPILDAMDAKKR 494
BLAST of HPO vs. Ensembl Medaka
Match: stk3 (serine/threonine-protein kinase 3 [Source:NCBI gene;Acc:101155570]) HSP 1 Score: 436.417 bits (1121), Expect = 2.416e-148 Identity = 234/480 (48.75%), Postives = 317/480 (66.04%), Query Frame = 3
Query: 33 DDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIR-ENRQHEEDTIQSRGSVTEEERTTDNGTMVRCSGDTATSLSSESSM------IVRDSLSSSVEAPTMLINATDDDSEAGGDTLTEQPHKSNKSPSQF--------AHQKKLQENGVKESAAQSPCG--PLNPNAFVNVEEI-----YRNLETKSYNELQQLLSRIDSDLQAELNNLEIRYLHKRQPILDAISEKSK 1406
+D L K+P EVF + KLG+GSYGSV+KA HK++G VA K VPV+S+L +I+KEISIMQQC S Y+V+YYGS++ + DLWIVMEYCGAGSVSDI+RLRNKT E+EIA IL+ +LKGLEY+H ++KIHRDIKAGNILL EG+AKLADFGVAGQL+DT+AKRNTVIGTP+WMAPEVIQEIGY+ ADIWSLGIT+IEMA+GKPPYADIHPMRA+FMIP+ PPPT P +WS F +F+ +CLVKNP+QR +A+QLL + FI A L I +A E++ + +Q ++ ++ +EEE D+ TMV+ + A ++ + +M ++ + + TM+IN D + ++ P F +++ Q+ + Q P G + N F + ++ + L+ + ELQ LS +D ++ E+ L RY KRQPILDA+ K +
Sbjct: 19 EDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQH-PFISQAKPVTILRDLITEAMEMKAKRQQEQQRELEEEEDNSEEETEVDSHTMVKSGSEGAGTMRATGTMSDGAQTMIEHGTTILDDLGTMVINTDDKEEHEDHGSMRRNPTAQQPIRPAFMDYFDKQDSNKATQQQENYNHNQLQEPSGYHIQSKNVFPDNWKVPQDGDFDFLKNLDFEELQLRLSALDPMMEREIEELRQRYTAKRQPILDAMDAKKR 497
BLAST of HPO vs. Ensembl Medaka
Match: ENSORLT00000044704.1 (serine/threonine-protein kinase 4 [Source:NCBI gene;Acc:101175466]) HSP 1 Score: 426.787 bits (1096), Expect = 5.348e-145 Identity = 212/378 (56.08%), Postives = 277/378 (73.28%), Query Frame = 3
Query: 18 MEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIRENRQHE--------------EDTIQSRGSVTEEERTTDNGTMVRCSGDTATSLSSESSMIV--RDSLSSSVEAPTMLINATDDDSEAGG 1103
++KL +D L K+P EVF + KLG+GSYG V+KA +K+ G VA K VPV+S+L +I+KEISIMQQC S ++V+YYGS++ + DLWIVMEYCGAGSVSDI+R+RNKT +EEEIA ++ +LKGLEY+H ++KIHRDIKAGNILL EG AKLADFGVAGQL+DT+AKRNTVIGTP+WMAPEVIQEIGY+ ADIWSLGITAIEMA+GKPPYADIHPMRA+FMIP+ PPPT NP +WS +F +F++QCLVKNP+ R +A+QLL + FI +A L + I A EI+ +Q E ++ +G++ T D+GT +R +G A SLS ++ D+ + + TM+IN+ ++D E G
Sbjct: 17 LKKLSEDSLTKQPEEVFDVLEKLGEGSYGCVFKANYKETGEIVAIKQVPVESDLQEIIKEISIMQQCNSPHVVRYYGSYFKNSDLWIVMEYCGAGSVSDIIRIRNKTLSEEEIATVVHSTLKGLEYLHFMRKIHRDIKAGNILLNAEGQAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRNPDLWSENFRDFVSQCLVKNPENRATATQLLQH-PFIKSAKPNSVLKSMITDAMEIKLKKQEEALQREQEAEDEDNSDEDEVDQGTMV-RAGTGDSGT-IRAAGSLARSLSDTCRTMIEHEDTGTMQSQLGTMVINSDEEDEEECG 391
BLAST of HPO vs. Ensembl Medaka
Match: stk3 (serine/threonine-protein kinase 3 [Source:NCBI gene;Acc:101155570]) HSP 1 Score: 341.273 bits (874), Expect = 2.922e-111 Identity = 202/486 (41.56%), Postives = 278/486 (57.20%), Query Frame = 3
Query: 180 SDIVKEISIMQQCK---------SDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIR-ENRQHEEDTIQSRGSVTEEERTTDNGTMVRCSGDTATSLSSESSM------IVRDSLSSSVEAPTMLINATDDDSEAGGDTLTEQPHKSNKSPSQF--------AHQKKLQENGVKESAAQSPCG-------------------------------PLNPNAF-VNVEEIYRNLETK-SY------------NELQQL--------LSRIDSDLQAELNNLEIRYLHKRQPILDAISEKSK 1406
SD+ + S+ + K S Y+V+YYGS++ + DLWIVMEYCGAGSVSDI+RLRNKT E+EIA IL+ +LKGLEY+H ++KIHRDIKAGNILL EG+AKLADFGVAGQL+DT+AKRNTVIGTP+WMAPEVIQEIGY+ ADIWSLGIT+IEMA+GKPPYADIHPMRA+FMIP+ PPPT P +WS F +F+ +CLVKNP+QR +A+QLL + FI A L I +A E++ + +Q ++ ++ +EEE D+ TMV+ + A ++ + +M ++ + + TM+IN D + ++ P F +++ Q+ + Q P G P+ N + + + R + K SY N+L+ L LS +D ++ E+ L RY KRQPILDA+ K +
Sbjct: 17 SDVCRNTSLFLRFKYKLCSEPLSSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQH-PFISQAKPVTILRDLITEAMEMKAKRQQEQQRELEEEEDNSEEETEVDSHTMVKSGSEGAGTMRATGTMSDGAQTMIEHGTTILDDLGTMVINTDDKEEHEDHGSMRRNPTAQQPIRPAFMDYFDKQDSNKATQQQENYNHNQLQEPSGYHIQSKNVFPDNWKVPQDGDFDFVSFSGVLFPIKKNLINIGLHDFKRAQQVKCSYSLLLFFCFVFLVNQLKNLDFEELQLRLSALDPMMEREIEELRQRYTAKRQPILDAMDAKKR 501
BLAST of HPO vs. Planmine SMEST
Match: SMESG000018196.1 (SMESG000018196.1) HSP 1 Score: 978.778 bits (2529), Expect = 0.000e+0 Identity = 471/472 (99.79%), Postives = 472/472 (100.00%), Query Frame = 3
Query: 18 MEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIRENRQHEEDTIQSRGSVTEEERTTDNGTMVRCSGDTATSLSSESSMIVRDSLSSSVEAPTMLINATDDDSEAGGDTLTEQPHKSNKSPSQFAHQKKLQENGVKESAAQSPCGPLNPNAFVNVEEIYRNLETKSYNELQQLLSRIDSDLQAELNNLEIRYLHKRQPILDAISEKSKPIAASVNSK 1433
MEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTE+GNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIRENRQHEEDTIQSRGSVTEEERTTDNGTMVRCSGDTATSLSSESSMIVRDSLSSSVEAPTMLINATDDDSEAGGDTLTEQPHKSNKSPSQFAHQKKLQENGVKESAAQSPCGPLNPNAFVNVEEIYRNLETKSYNELQQLLSRIDSDLQAELNNLEIRYLHKRQPILDAISEKSKPIAASVNSK
Sbjct: 1 MEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEDGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQANEIRENRQHEEDTIQSRGSVTEEERTTDNGTMVRCSGDTATSLSSESSMIVRDSLSSSVEAPTMLINATDDDSEAGGDTLTEQPHKSNKSPSQFAHQKKLQENGVKESAAQSPCGPLNPNAFVNVEEIYRNLETKSYNELQQLLSRIDSDLQAELNNLEIRYLHKRQPILDAISEKSKPIAASVNSK 472
BLAST of HPO vs. Planmine SMEST
Match: SMESG000010489.1 (SMESG000010489.1) HSP 1 Score: 263.848 bits (673), Expect = 2.810e-81 Identity = 127/255 (49.80%), Postives = 177/255 (69.41%), Query Frame = 3
Query: 51 EPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVDSELSDIV---KEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVIQEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLL 806
+P V+ + ++GKGS+G V+K +K + VA K++ ++ +I +EI+++ QC S Y+ +Y+GS+ LWI+MEY G GS D+M+ NE IAIIL+ LKGL+Y+H KK+HRDIKA N+LL+E G+ KLADFGVAGQL++T KR T +GTP+WMAPEVI++ Y + ADIWSLGITAIE+A G+PP++++HPMR LF+IP P P L +S F +F+ CL K PD RPSA +LL
Sbjct: 13 DPETVYDVLERIGKGSFGEVHKGVNKIDKTIVAIKIIDLEEAEDEIEDIQQEINVLSQCDSPYVTKYFGSYLKVTKLWIIMEYLGGGSAMDLMK--PGPLNETYIAIILREILKGLDYLHSQKKLHRDIKAANVLLSENGDVKLADFGVAGQLTNTTNKRVTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPHSNLHPMRVLFLIPKNPSPQL--DGSFSKLFRDFVDCCLNKEPDNRPSARELL 263
BLAST of HPO vs. Planmine SMEST
Match: SMESG000041176.1 (SMESG000041176.1) HSP 1 Score: 241.506 bits (615), Expect = 5.181e-70 Identity = 123/281 (43.77%), Postives = 182/281 (64.77%), Query Frame = 3
Query: 54 PSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVD--SELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVI----QEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQ--PPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQA 872
P + +++ S++G G+YG VYKA H K+ VA K++ +D +++ I +EI +++CK D IVQ++GS+ + LWI MEYCG S+ DI + E+ IA I + +LKGL+Y+H+ +IHRDIK NILLT+ G+ K+ADFG+A +LS T+AKR T+IGTPYWMAPEV + GY D+W++GITAIE A+ +PP D+HPM+AL ++ + PP L IWS F +F+ L KN +RP +L + +F+ + +HL T+ QA
Sbjct: 18 PKDEYKLISEIGSGTYGDVYKAMHVKSQNYVAIKIMKIDLKDDVTAICQEIHTLRECKHDNIVQFFGSYLQASKLWICMEYCGGQSMQDIYLNLRRPIIEDCIAFITRETLKGLDYMHKRGRIHRDIKGANILLTDLGDVKIADFGIAAKLSSTVAKRTTLIGTPYWMAPEVAAVNNRTGGYDERCDVWAVGITAIEYAELQPPLFDLHPMKALQILAQRTYTPPKLQKKEIWSAKFHSFLRFALAKNEKKRPYCETMLTH-DFV----TQEHLSITLTQA 293
BLAST of HPO vs. Planmine SMEST
Match: SMESG000041176.1 (SMESG000041176.1) HSP 1 Score: 241.121 bits (614), Expect = 5.922e-70 Identity = 123/281 (43.77%), Postives = 182/281 (64.77%), Query Frame = 3
Query: 54 PSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVD--SELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVI----QEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQ--PPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQA 872
P + +++ S++G G+YG VYKA H K+ VA K++ +D +++ I +EI +++CK D IVQ++GS+ + LWI MEYCG S+ DI + E+ IA I + +LKGL+Y+H+ +IHRDIK NILLT+ G+ K+ADFG+A +LS T+AKR T+IGTPYWMAPEV + GY D+W++GITAIE A+ +PP D+HPM+AL ++ + PP L IWS F +F+ L KN +RP +L + +F+ + +HL T+ QA
Sbjct: 18 PKDEYKLISEIGSGTYGDVYKAMHVKSQNYVAIKIMKIDLKDDVTAICQEIHTLRECKHDNIVQFFGSYLQASKLWICMEYCGGQSMQDIYLNLRRPIIEDCIAFITRETLKGLDYMHKRGRIHRDIKGANILLTDLGDVKIADFGIAAKLSSTVAKRTTLIGTPYWMAPEVAAVNNRTGGYDERCDVWAVGITAIEYAELQPPLFDLHPMKALQILAQRTYTPPKLQKKEIWSAKFHSFLRFALAKNEKKRPYCETMLTH-DFV----TQEHLSITLTQA 293
BLAST of HPO vs. Planmine SMEST
Match: SMESG000041176.1 (SMESG000041176.1) HSP 1 Score: 240.736 bits (613), Expect = 6.405e-70 Identity = 123/281 (43.77%), Postives = 182/281 (64.77%), Query Frame = 3
Query: 54 PSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPVD--SELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMRLRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEEGNAKLADFGVAGQLSDTLAKRNTVIGTPYWMAPEVI----QEIGYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQ--PPPTLLNPSIWSPSFVNFITQCLVKNPDQRPSASQLLLNCEFIINASSPDHLIATIKQA 872
P + +++ S++G G+YG VYKA H K+ VA K++ +D +++ I +EI +++CK D IVQ++GS+ + LWI MEYCG S+ DI + E+ IA I + +LKGL+Y+H+ +IHRDIK NILLT+ G+ K+ADFG+A +LS T+AKR T+IGTPYWMAPEV + GY D+W++GITAIE A+ +PP D+HPM+AL ++ + PP L IWS F +F+ L KN +RP +L + +F+ + +HL T+ QA
Sbjct: 18 PKDEYKLISEIGSGTYGDVYKAMHVKSQNYVAIKIMKIDLKDDVTAICQEIHTLRECKHDNIVQFFGSYLQASKLWICMEYCGGQSMQDIYLNLRRPIIEDCIAFITRETLKGLDYMHKRGRIHRDIKGANILLTDLGDVKIADFGIAAKLSSTVAKRTTLIGTPYWMAPEVAAVNNRTGGYDERCDVWAVGITAIEYAELQPPLFDLHPMKALQILAQRTYTPPKLQKKEIWSAKFHSFLRFALAKNEKKRPYCETMLTH-DFV----TQEHLSITLTQA 293 The following BLAST results are available for this feature:
BLAST of HPO vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of HPO vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of HPO vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of HPO vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of HPO vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of HPO vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of HPO vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of HPO vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of HPO vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of HPO vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of HPO vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of HPO vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of HPO vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of HPO vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Cross References
External references for this transcript
Sequences
The following sequences are available for this feature:
transcript sequence >SMED30030624 ID=SMED30030624|Name=HPO|organism=Schmidtea mediterranea sexual|type=transcript|length=1645bpback to top protein sequence of SMED30030624-orf-1 >SMED30030624-orf-1 ID=SMED30030624-orf-1|Name=SMED30030624-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=474bp MMEKLLDDDLQKEPSEVFQIESKLGKGSYGSVYKAKHKKNGFTVAAKLVPback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
|
