Mitogen-activated protein kinase kinase kinase 4

Overview
NameMitogen-activated protein kinase kinase kinase 4
Smed IDSMED30030550
Length (bp)5221
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Mitogen-activated protein kinase kinase kinase 4 (SMED30030550) t-SNE clustered cells

Violin plots show distribution of expression levels for Mitogen-activated protein kinase kinase kinase 4 (SMED30030550) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Mitogen-activated protein kinase kinase kinase 4 (SMED30030550) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Mitogen-activated protein kinase kinase kinase 4 (SMED30030550) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30030550

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 9

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
protonephridiaSMED30030550SMESG000054074.1 dd_Smed_v4_3368_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30030550SMESG000054074.1 dd_Smed_v4_3368_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30030550SMESG000054074.1 dd_Smed_v4_3368_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30030550SMESG000054074.1 dd_Smed_v4_3368_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30030550SMESG000054074.1 Contig42890newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30030550SMESG000054074.1 Contig42890uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30030550SMESG000029377.1 Contig43796newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30030550SMESG000029377.1 Contig43796uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
parenchymal cellSMED30030550SMESG000054074.1 dd_Smed_v6_3368_0dd_Smed_v6PMID:29674432
Plass et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Human
Match: MAP3K4 (mitogen-activated protein kinase kinase kinase 4 [Source:HGNC Symbol;Acc:HGNC:6856])

HSP 1 Score: 267.7 bits (683), Expect = 1.364e-71
Identity = 260/1066 (24.39%), Postives = 460/1066 (43.15%), Query Frame = 3 
Query: 1923 LSLPPLLPHYLFLVKFPIKLMHCCIRKILGSPDISKISELSVITIKQRIIDFKDALQFTMRARQFLFDYTFGINFQINKFLASNSKDFAPKQDVDLSDFLSSSMKEIDGDLSSLLRHYIDCXXXXXXXXXXXXXXXXFEYGEPRKLLEEEWTFVKTYCHNIKQEEEIVASSFCNLAEYLFDLLQSRIESDYKLXXXXXXXXXXXXXXXXAEEDILSVSSINNRRMSKCCQTYNNKCKMIQSQLKQAADFSKMLRSDLEISIQLELNLNYSMNDLLSFLSLTKHKMIDLCSSDEQSSINPIDLTLIIPE---ESSSFIKELLDPLITGFSIHPKDDTVRTTLLNSSSSKPRCIKSREYILIINKKSKINWPGEKIKFIYQLDIGNLKQRIESSNIVFLARRPDELTEQLSHLLEFKIPSKHHNIQFKNVIQSCSEGQVEACHYNSK------RTLNALKSKAIEIGQVLHNFFMYDKNDSFSVSELNKIQEET--------VRNSIKNSYSIIFEFYRDLIKLCTGDAFKTVLKNTIVGLLEKWFEFSRKFEPSEKGTVPRWANDGLNFLLQLCQSRVVMTMTKKEWHDFKKSIDNFVEFIVGKSNRH----HXXXXXXXXXXXXXXXXXRSWLVTPKPDVIRGCENNASNSKKIENWDIKCDNRTLRSAFSEPSRMISSDQNSFPNQLDRHIDMKTPGNFNEISFTRSITVAEQGLEHSRDAPNSNKSTDGSSNEDHKDRKRVTLKQAIVELENQLNEKRRQNNLMGFVRDS--NSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVI----NEPFSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLK----DIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQH-LAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKL 5024
            + LP   P +L L +  + ++H C++  L   +     E S+++IKQ + + K+ L+  +  +Q+             +F+     +   K D ++  F        + DL  +L  Y D ++  ++   +   +        + LLEEEW F K   H I+  E      FC++A  L     S +E  + L          +   S ++E   SV  I     S+  +   ++ +    +  +A  F+KMLR DLEI+   E  L+  + DLL  L   ++  + +   +        +L + +P+   E  S I +LL+           DD +    L  +    R   S +        S   W  + +K + Q++  +  + ++  N++ +                  + S H  IQ K   QS  EG +  C   +       + L  LK+ A+E+   + N    D+ D    SE +   +E+         R ++   Y+  FE+++++++L +G+ F+  + +  +    KW  +      S +GT PRWA  G +FL Q  +   +  + + ++   +  ++  +  ++GK +      H  +                 L+ P P+  RG  ++   + ++ +   +   R+L S  S P+     D+ ++P               +    TR        +  S+D  +     +              +++++   E +   + R+ N++G V D+  + DN     ++K  F+W +   IG+G  G V+   ++DT E+MAMKEI      ++   +   E  +   + H +L++Y GV++    M IF EYC+ G+L +VS L + E  +R ++KQI  AI  LH H IVHRD+K  NIFL     T+    KLGDFG +  L N+   +        GT  YMAPEV            G+    DIWSLGC+V+ M+TGK PW EY+H   I Y +GM   P IP      R++ E +DF+  CL+ +P  R  A  LL+ +FVK+
Sbjct:  607 MDLPSFEPAFLVLCRVLLNVIHECLKLRL---EQRPAGEPSLLSIKQLVRECKEVLKGGLLMKQYY------------QFMLQEVLEDLEKPDCNIDAF--------EEDLHKMLMVYFDYMRSWIQMLQQLPQASH----SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLE--FGLQESCAEFWTSADDSSASDEIRRSVIEI-----SRALKELFHEAR---ERASKALGFAKMLRKDLEIAA--EFRLSAPVRDLLDVLKSKQYVKVQIPGLE--------NLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAYLLLTKHGDRARDSED--------SWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVV-----------------MQSAHLTIQRKAFQQSI-EGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAI--DRVDHMFTSEFDAEVDESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGE-FRQKIGDKYISFARKWMNYVLTKCESGRGTRPRWATQGFDFL-QAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFRG--SSVPENDRLASIAAELQFRSL-SRHSSPTE--ERDEPAYPRG-------------DSSGSTRRSWELRTLISQSKDTASKLGPIEA-------------IQKSVRLFEEKRYREMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFL-----TSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVIT-----RAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIP-----ERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKV 1549
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Human
Match: MAP3K4 (mitogen-activated protein kinase kinase kinase 4 [Source:HGNC Symbol;Acc:HGNC:6856])

HSP 1 Score: 265.774 bits (678), Expect = 5.225e-71
Identity = 260/1070 (24.30%), Postives = 460/1070 (42.99%), Query Frame = 3 
Query: 1923 LSLPPLLPHYLFLVKFPIKLMHCCIRKILGSPDISKISELSVITIKQRIIDFKDALQFTMRARQFLFDYTFGINFQINKFLASNSKDFAPKQDVDLSDFLSSSMKEIDGDLSSLLRHYIDCXXXXXXXXXXXXXXXXFEYGEPRKLLEEEWTFVKTYCHNIKQEEEIVASSFCNLAEYLFDLLQSRIESDYKLXXXXXXXXXXXXXXXXAEEDILSVSSINNRRMSKCCQTYNNKCKMIQSQLKQAADFSKMLRSDLEISIQLELNLNYSMNDLLSFLSLTKHKMIDLCSSDEQSSINPIDLTLIIPE---ESSSFIKELLDPLITGFSIHPKDDTVRTTLLNSSSSKPRCIKSREYILIINKKSKINWPGEKIKFIYQLDIGNLKQRIESSNIVFLARRPDELTEQLSHLLEFKIPSKHHNIQFKNVIQSCSEGQVEACHYNSK------RTLNALKSKAIEIGQVLHNFFMYDKNDSFSVSELNKIQEET--------VRNSIKNSYSIIFEFYRDLIKLCTGDAFKTVLKNTIVGLLEKWFEFSRKFEPSEKGTVPRWANDGLNFLLQLCQSRVVMTMTKKEWHDFKKSIDNFVEFIVGKSNRH--------HXXXXXXXXXXXXXXXXXRSWLVTPKPDVIRGCENNASNSKKIENWDIKCDNRTLRSAFSEPSRMISSDQNSFPNQLDRHIDMKTPGNFNEISFTRSITVAEQGLEHSRDAPNSNKSTDGSSNEDHKDRKRVTLKQAIVELENQLNEKRRQNNLMGFVRDS--NSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVI----NEPFSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLK----DIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQH-LAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKL 5024
            + LP   P +L L +  + ++H C++  L   +     E S+++IKQ + + K+ L+  +  +Q+             +F+     +   K D ++  F        + DL  +L  Y D ++  ++   +   +        + LLEEEW F K   H I+  E      FC++A  L     S +E  + L          +   S ++E   SV  I     S+  +   ++ +    +  +A  F+KMLR DLEI+   E  L+  + DLL  L   ++  + +   +        +L + +P+   E  S I +LL+           DD +    L  +    R   S +        S   W  + +K + Q++  +  + ++  N++ +                  + S H  IQ K   QS  EG +  C   +       + L  LK+ A+E+   + N    D+ D    SE +   +E+         R ++   Y+  FE+++++++L +G+ F+  + +  +    KW  +      S +GT PRWA  G +FL Q  +   +  + + ++   +  ++  +  ++GK +          H  +                 L+ P P+  RG  ++   + ++ +   +   R+L S  S P+     D+ ++P               +    TR        +  S+D  +     +              +++++   E +   + R+ N++G V D+  + DN     ++K  F+W +   IG+G  G V+   ++DT E+MAMKEI      ++   +   E  +   + H +L++Y GV++    M IF EYC+ G+L +VS L + E  +R ++KQI  AI  LH H IVHRD+K  NIFL     T+    KLGDFG +  L N+   +        GT  YMAPEV            G+    DIWSLGC+V+ M+TGK PW EY+H   I Y +GM   P IP      R++ E +DF+  CL+ +P  R  A  LL+ +FVK+
Sbjct:  607 MDLPSFEPAFLVLCRVLLNVIHECLKLRL---EQRPAGEPSLLSIKQLVRECKEVLKGGLLMKQYY------------QFMLQEVLEDLEKPDCNIDAF--------EEDLHKMLMVYFDYMRSWIQMLQQLPQASH----SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLE--FGLQESCAEFWTSADDSSASDEIRRSVIEI-----SRALKELFHEAR---ERASKALGFAKMLRKDLEIAA--EFRLSAPVRDLLDVLKSKQYVKVQIPGLE--------NLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAYLLLTKHGDRARDSED--------SWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVV-----------------MQSAHLTIQRKAFQQSI-EGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAI--DRVDHMFTSEFDAEVDESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGE-FRQKIGDKYISFARKWMNYVLTKCESGRGTRPRWATQGFDFL-QAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGLYLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFRG--SSVPENDRLASIAAELQFRSL-SRHSSPTE--ERDEPAYPRG-------------DSSGSTRRSWELRTLISQSKDTASKLGPIEA-------------IQKSVRLFEEKRYREMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFL-----TSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVIT-----RAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIP-----ERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKV 1553
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Human
Match: MAP3K4 (mitogen-activated protein kinase kinase kinase 4 [Source:HGNC Symbol;Acc:HGNC:6856])

HSP 1 Score: 263.462 bits (672), Expect = 2.618e-70
Identity = 269/1089 (24.70%), Postives = 464/1089 (42.61%), Query Frame = 3 
Query: 1923 LSLPPLLPHYLFLVKFPIKLMHCCIRKILGSPDISKISELSVITIKQRIIDFKDALQFTMRARQFLFDYTFGINFQINKFLASNSKDFAPKQDVDLSDFLSSSMKEIDGDLSSLLRHYIDCXXXXXXXXXXXXXXXXFEYGEPRKLLEEEWTFVKTYCHNIKQEEEIVASSFCNLAEYLFDLLQSRIESDYKLXXXXXXXXXXXXXXXXAEEDILSVSSINNRRMSKCCQTYNNKCKMIQSQLKQAADFSKMLRSDLEISIQLELNLNYSMNDLLSFLSLTKHKMIDLCSSDEQSSINPIDLTLIIPE---ESSSFIKELLDPLITGFSIHPKDDTVRTTLLNSSSSKPRCIKSREYILIINKKSKINWPGEKIKFIYQLDIGNLKQRIESSNIVFLARRPDELTEQLSHLLEFKIPSKHHNIQFKNVIQSCSEGQVEACHYNS------KRTLNALKSKAIEIGQVLHNFFMYDKNDSFSVSELNKIQEET--------VRNSIKNSYSIIFEFYRDLIKLCTGDAFKTVLKNTIVGLLEKWFEFSRKFEPSEKGTVPRWANDGLNFLLQLCQSRVVMTMTKKEWHDFKKSIDNFVEFIVGKSNRH----HXXXXXXXXXXXXXXXXXRSWLVTPKPDVIRGCENNASNSKKIENWDIKCDNRTLRSAFSEPSRMISSDQNSFPNQLDRHIDMK---TPGN------FNEISFTRSITVAEQGLEHSRDAPNSNKSTDGSSNEDHKDRKRVTLK----------QAIVELENQLNEKR----RQNNLMGFVRDS--NSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVI----NEPFSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLK----DIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQH-LAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKL 5024
            + LP   P +L L +  + ++H C++  L   +     E S+++IKQ + + K+ L+  +  +Q+             +F+     +   K D ++  F        + DL  +L  Y D ++  ++   +   +        + LLEEEW F K   H I+  E      FC++A  L     S +E  + L          +   S ++E   SV  I     S+  +   ++ +    +  +A  F+KMLR DLEI+   E  L+  + DLL  L   ++  + +   +        +L + +P+   E  S I +LL+           DD +    L  +    R   S +        S   W  + +K + Q++  +  + ++  N++ +                  + S H  IQ K   QS  EG +  C   +       + L  LK+ A+E+   + N    D+ D    SE +   +E+         R ++   Y+  FE+++++++L +G+ F+  + +  +    KW  +      S +GT PRWA  G +F LQ  +   +  + + ++   +  ++  +  ++GK +      H  +                 L+ P P+      +  S+++   +            A S PS   S   +  P  +    D +    P N        E+ F RS++      E   +       + GS+    + R  ++            +AI +      EKR    R+ N++G V D+  + DN     ++K  F+W +   IG+G  G V+   ++DT E+MAMKEI      ++   +   E  +   + H +L++Y GV++    M IF EYC+ G+L +VS L + E  +R ++KQI  AI  LH H IVHRD+K  NIFL     T+    KLGDFG +  L N+   +        GT  YMAPEV            G+    DIWSLGC+V+ M+TGK PW EY+H   I Y +GM   P IP      R++ E +DF+  CL+ +P  R  A  LL+ +FVK+
Sbjct:  607 MDLPSFEPAFLVLCRVLLNVIHECLKLRL---EQRPAGEPSLLSIKQLVRECKEVLKGGLLMKQYY------------QFMLQEVLEDLEKPDCNIDAF--------EEDLHKMLMVYFDYMRSWIQMLQQLPQASH----SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLE--FGLQESCAEFWTSADDSSASDEIRRSVIEI-----SRALKELFHEAR---ERASKALGFAKMLRKDLEIAA--EFRLSAPVRDLLDVLKSKQYVKVQIPGLE--------NLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAYLLLTKHGDRARDSED--------SWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVV-----------------MQSAHLTIQRKAFQQSI-EGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAI--DRVDHMFTSEFDAEVDESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGE-FRQKIGDKYISFARKWMNYVLTKCESGRGTRPRWATQGFDF-LQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGF-STRSMPSDARSHGSPAAAAAAAAAAVAASRPS--PSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQF-RSLSRHSSPTEERDEPAYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFL-----TSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVIT-----RAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIP-----ERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKV 1599
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Human
Match: MAP3K4 (mitogen-activated protein kinase kinase kinase 4 [Source:HGNC Symbol;Acc:HGNC:6856])

HSP 1 Score: 200.29 bits (508), Expect = 9.459e-51
Identity = 118/323 (36.53%), Postives = 176/323 (54.49%), Query Frame = 3 
Query: 4089 TLKQAIVELENQLNEKRRQNNLMGFVRDS--NSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVI----NEPFSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLK----DIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQH-LAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKL 5024
             +++++   E +   + R+ N++G V D+  + DN     ++K  F+W +   IG+G  G V+   ++DT E+MAMKEI      ++   +   E  +   + H +L++Y GV++    M IF EYC+ G+L +VS L + E  +R ++KQI  AI  LH H IVHRD+K  NIFL     T+    KLGDFG +  L N+   +        GT  YMAPEV            G+    DIWSLGC+V+ M+TGK PW EY+H   I Y +GM   P IP      R++ E +DF+  CL+ +P  R  A  LL+ +FVK+
Sbjct: 1296 AIQKSVRLFEEKRYREMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFL-----TSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVIT-----RAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIP-----ERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKV 1603

HSP 2 Score: 93.5893 bits (231), Expect = 2.939e-18
Identity = 125/605 (20.66%), Postives = 247/605 (40.83%), Query Frame = 3 
Query: 1923 LSLPPLLPHYLFLVKFPIKLMHCCIRKILGSPDISKISELSVITIKQRIIDFKDALQFTMRARQFLFDYTFGINFQINKFLASNSKDFAPKQDVDLSDFLSSSMKEIDGDLSSLLRHYIDCXXXXXXXXXXXXXXXXFEYGEPRKLLEEEWTFVKTYCHNIKQEEEIVASSFCNLAEYLFDLLQSRIESDYKLXXXXXXXXXXXXXXXXAEEDILSVSSINNRRMSKCCQTYNNKCKMIQSQLKQAADFSKMLRSDLEISIQLELNLNYSMNDLLSFLSLTKHKMIDLCSSDEQSSINPIDLTLIIPE---ESSSFIKELLDPLITGFSIHPKDDTVRTTLLNSSSSKPRCIKSREYILIINKKSKINWPGEKIKFIYQLDIGNLKQRIESSNIVFLARRPDELTEQLSHLLEFKIPSKHHNIQFKNVIQSCSEGQVEACHYNS------KRTLNALKSKAIEIGQVLHNFFMYDKNDSFSVSELNKIQEET--------VRNSIKNSYSIIFEFYRDLIKLCTGDAFKTVLKNTIVGLLEKWFEFSRKFEPSEKGTVPRWANDGLNFLLQLCQSRVVMTMTKKEWHDFKKSIDNFVEFIVGKSN 3686
            + LP   P +L L +  + ++H C++  L   +     E S+++IKQ + + K+ L+  +  +Q+             +F+     +   K D ++  F        + DL  +L  Y D ++  ++   +   +        + LLEEEW F K   H I+  E      FC++A  L     S +E  + L          +   S ++E   SV  I     S+  +   ++ +    +  +A  F+KMLR DLEI+   E  L+  + DLL  L   ++  + +   +        +L + +P+   E  S I +LL+           DD +    L  +    R   S +        S   W  + +K + Q++  +  + ++  N++ +                  + S H  IQ K   QS  EG +  C   +       + L  LK+ A+E+   + N    D+ D    SE +   +E+         R ++   Y+  FE+++++++L +G+ F+  + +  +    KW  +      S +GT PRWA  G +F LQ  +   +  + + ++   +  ++  +  ++GK +
Sbjct:  607 MDLPSFEPAFLVLCRVLLNVIHECLKLRL---EQRPAGEPSLLSIKQLVRECKEVLKGGLLMKQYY------------QFMLQEVLEDLEKPDCNIDAF--------EEDLHKMLMVYFDYMRSWIQMLQQLPQASH----SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLE--FGLQESCAEFWTSADDSSASDEIRRSVIEI-----SRALKELFHEAR---ERASKALGFAKMLRKDLEIAA--EFRLSAPVRDLLDVLKSKQYVKVQIPGLE--------NLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAYLLLTKHGDRARDSED--------SWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVV-----------------MQSAHLTIQRKAFQQSI-EGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAI--DRVDHMFTSEFDAEVDESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGE-FRQKIGDKYISFARKWMNYVLTKCESGRGTRPRWATQGFDF-LQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPH 1134
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855])

HSP 1 Score: 150.984 bits (380), Expect = 7.820e-37
Identity = 103/311 (33.12%), Postives = 163/311 (52.41%), Query Frame = 3 
Query: 4158 GFVRDSNSDNTSSCYIK-------KAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDL------IECD--LLCKLNHASLLKYHGV--DISLSHMRIFTEYCEGGSLSQV--SILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVN---HLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKL 5024
            G +R ++S+N  S   +        AP  W +  L+GQG  G V+   ++DT   +A K++  + P S +       +EC+  LL  L H  +++Y+G   D +   + IF EY  GGS+     +   + E   R++T+QILE + +LHS+ IVHRD+K  NI L++  G    + KLGDFG +K L        G++ + GT  +M+PEV         S  GY  K D+WSLGC V+ M+T KPPW EY+ +A  + +  +  P  P + S   +++  RDF+     +   +R  A +LL  +F +L
Sbjct:  329 GRLRSADSENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFD-PDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANI-LRDSAG----NVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVI--------SGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQ--PTNPQLPS--HISEHGRDFLRRIF-VEARQRPSAEELLTHHFAQL 620
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Celegans
Match: mtk-1 (MTK1/MEKK4 homolog [Source:UniProtKB/TrEMBL;Acc:O01837])

HSP 1 Score: 157.147 bits (396), Expect = 4.937e-38
Identity = 107/331 (32.33%), Postives = 163/331 (49.24%), Query Frame = 3 
Query: 4062 EDHKDRKRVTLKQAIVELENQLNEKRRQNNLMG-FVRDSNSDN----TSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDL-IECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHA-KLGDFGVAKCLVNH---LDGLKDIKGTVMYMAPEVAVVDS--EQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFV 5018
            E+HK  ++      + ELE++ N     N  +G  + D N  N    T      KAPFQW     I  G  G+V +  ++D+  ++A K + I     + +  E ++  +L H +L+KY+GV +  S + IF EYC  G+L ++    +    +RQ+T  +L A+ +LHSHKI+HRD+KP NIFL      ++C   KLGDFG +  LV         +   GT  +MAPE+       E   S  GY   VDIW+LG  V+ M+TGK P++      I + L  +K    P     A    + + F   C +  P++R  A +LL   F 
Sbjct: 1066 ENHKRTRKENQMLKLQELEDKRNRIDYDNLQIGKVITDDNRRNFVLATDKKITTKAPFQWALLDHIASGSFGSVHRAMDIDSHRVIAAKVMRIQRENHKAIESEINIFRQLIHENLVKYYGVQVEDSDVIIFMEYCSQGTLERICHGKMDLKMVRQYTNSLLRAVQYLHSHKIIHRDIKPANIFL------DKCTVLKLGDFGCSSRLVESSTVYGEFQTTAGTPQFMAPEIYSYGEKDETTGSYSGYGRSVDIWALGATVVNMMTGKVPFEGQTRHQIAFALCFRKQK--PTYPDIADKRPDVKRFFDNCFEFLPNDRPTAAELLQTTFA 1388
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Celegans
Match: mtk-1 (MTK1/MEKK4 homolog [Source:UniProtKB/TrEMBL;Acc:O01837])

HSP 1 Score: 157.147 bits (396), Expect = 4.944e-38
Identity = 107/331 (32.33%), Postives = 163/331 (49.24%), Query Frame = 3 
Query: 4062 EDHKDRKRVTLKQAIVELENQLNEKRRQNNLMG-FVRDSNSDN----TSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDL-IECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHA-KLGDFGVAKCLVNH---LDGLKDIKGTVMYMAPEVAVVDS--EQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFV 5018
            E+HK  ++      + ELE++ N     N  +G  + D N  N    T      KAPFQW     I  G  G+V +  ++D+  ++A K + I     + +  E ++  +L H +L+KY+GV +  S + IF EYC  G+L ++    +    +RQ+T  +L A+ +LHSHKI+HRD+KP NIFL      ++C   KLGDFG +  LV         +   GT  +MAPE+       E   S  GY   VDIW+LG  V+ M+TGK P++      I + L  +K    P     A    + + F   C +  P++R  A +LL   F 
Sbjct: 1066 ENHKRTRKENQMLKLQELEDKRNRIDYDNLQIGKVITDDNRRNFVLATDKKITTKAPFQWALLDHIASGSFGSVHRAMDIDSHRVIAAKVMRIQRENHKAIESEINIFRQLIHENLVKYYGVQVEDSDVIIFMEYCSQGTLERICHGKMDLKMVRQYTNSLLRAVQYLHSHKIIHRDIKPANIFL------DKCTVLKLGDFGCSSRLVESSTVYGEFQTTAGTPQFMAPEIYSYGEKDETTGSYSGYGRSVDIWALGATVVNMMTGKVPFEGQTRHQIAFALCFRKQK--PTYPDIADKRPDVKRFFDNCFEFLPNDRPTAAELLQTTFA 1388
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Celegans
Match: nsy-1 (Mitogen-activated protein kinase kinase kinase nsy-1 [Source:UniProtKB/Swiss-Prot;Acc:Q21029])

HSP 1 Score: 139.813 bits (351), Expect = 9.536e-33
Identity = 97/282 (34.40%), Postives = 144/282 (51.06%), Query Frame = 3 
Query: 4230 KKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVI--NEPFSQDLIECDLLCKLNHASLLKYHGVDI-----SLSHMRIFTEYCEGGSLSQVSIL-----DIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQH-LAIYYNLGM-KKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKLRNH 5033
            ++ ++G+G  GTV+   ++DT   + +KEI +  +E     + E  L   L HA++++Y G D+     S  H  IF E+  GGSLS  S+L      + E  +  + KQILE + +LH  KIVHRD+K DN+ +    G      K+ DFG  K L       +   GT+ YMAPEV       +  + GY    DIWS GC ++ M TG+PP+ E Q+  A  + +GM K  P IP       +T++ R+FI  C      +R  A DLL   F+   +H
Sbjct:  666 ERVVLGKGTYGTVYAARDMDTQRQIVVKEIEVKYDEEVQPLMEEISLHSTLCHANIVQYLGCDLVGKDGSNDHFLIFMEHVPGGSLS--SLLRSKWGPMNENAMNYYGKQILEGLKYLHELKIVHRDIKGDNVLVNTYSGV----CKISDFGTCKRLAGLNPVTETFTGTLQYMAPEVI------DHGQRGYGAPADIWSFGCTMVEMATGRPPFVEMQNPQAAMFRVGMFKTHPPIP-----TEITEKCRNFIKSCFLPEACDRPSAKDLLQDPFIYHNHH 930
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Celegans
Match: nsy-1 (Mitogen-activated protein kinase kinase kinase nsy-1 [Source:UniProtKB/Swiss-Prot;Acc:Q21029])

HSP 1 Score: 139.428 bits (350), Expect = 1.139e-32
Identity = 97/282 (34.40%), Postives = 144/282 (51.06%), Query Frame = 3 
Query: 4230 KKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVI--NEPFSQDLIECDLLCKLNHASLLKYHGVDI-----SLSHMRIFTEYCEGGSLSQVSIL-----DIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQH-LAIYYNLGM-KKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKLRNH 5033
            ++ ++G+G  GTV+   ++DT   + +KEI +  +E     + E  L   L HA++++Y G D+     S  H  IF E+  GGSLS  S+L      + E  +  + KQILE + +LH  KIVHRD+K DN+ +    G      K+ DFG  K L       +   GT+ YMAPEV       +  + GY    DIWS GC ++ M TG+PP+ E Q+  A  + +GM K  P IP       +T++ R+FI  C      +R  A DLL   F+   +H
Sbjct:  652 ERVVLGKGTYGTVYAARDMDTQRQIVVKEIEVKYDEEVQPLMEEISLHSTLCHANIVQYLGCDLVGKDGSNDHFLIFMEHVPGGSLS--SLLRSKWGPMNENAMNYYGKQILEGLKYLHELKIVHRDIKGDNVLVNTYSGV----CKISDFGTCKRLAGLNPVTETFTGTLQYMAPEVI------DHGQRGYGAPADIWSFGCTMVEMATGRPPFVEMQNPQAAMFRVGMFKTHPPIP-----TEITEKCRNFIKSCFLPEACDRPSAKDLLQDPFIYHNHH 916
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Celegans
Match: cst-1 (Serine/threonine-protein kinase cst-1 Serine/threonine-protein kinase cst-1 37kDa subunit Serine/threonine-protein kinase cst-1 18kDa subunit [Source:UniProtKB/Swiss-Prot;Acc:Q9NB31])

HSP 1 Score: 126.331 bits (316), Expect = 7.030e-30
Identity = 79/265 (29.81%), Postives = 128/265 (48.30%), Query Frame = 3 
Query: 4236 GLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSIL---DIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVK 5021
            G +G+G  G+V K  + ++  ++A+K++ ++    + + E  ++ +     ++KY+G     S + I  EYC  GS+S +       + E  +    +  L+ + +LH  K +HRD+K  NI L N +G     AKL DFGVA  L + +     + GT  +MAPEV          + GY+ K DIWSLG   + M  G+PP+ +   +   + +  K     P        + E  DFI  CL   P+ER  AL L    F+K
Sbjct:   39 GKLGEGSYGSVHKAIHRESGHVLAIKKVPVDTDLQEIIKEISIMQQCKSKYVVKYYGSYFKHSDLWIVMEYCGAGSISDIMRARRKPLSEQEISAVLRDTLKGLQYLHDLKKIHRDIKAGNILL-NTDGI----AKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI--------EEIGYDTKADIWSLGITAIEMAEGRPPYSDIHPMRAIFMIPTKP---PPTFKKPEEWSSEFNDFIRSCLIKKPEERKTALRLCEHTFIK 287
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Fly
Match: Mekk1 (gene:FBgn0024329 transcript:FBtr0083684)

HSP 1 Score: 185.652 bits (470), Expect = 1.206e-46
Identity = 117/327 (35.78%), Postives = 179/327 (54.74%), Query Frame = 3 
Query: 4071 KDRKRVTLKQAIVELENQLNEKRRQNNLMGFVRDSNSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDLI----ECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSIL--DIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLD---GLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEY-QHLAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVK 5021
            ++R R  + +  ++LE+ L E+R    L+G V+  NS +      +   F+W +   IGQG  G V+   N +T E+MAMKEI I    ++ L     E  +L  + H +L++Y+G+++    + IF E C  G+L  +  L  ++PE   R++T Q+L  +  LH H IVHRD+K  NIFL  ++G+N    KLGDFG A  +  H      L+   GT  YMAPEV    ++ N   HG     DIWS+GC+V+ M +GK PW ++  +  I + +GM + P  P       +++E  DFI  CL+ +P  RL A++LL  NF K
Sbjct: 1235 QERVRDAVNRLDMDLEDGLRERR----LIGQVKSLNSSDKVHIRARSVHFRWHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRALKNVAEELKILEGIKHKNLVRYYGIEVHREELLIFMELCSEGTLESLVELTGNLPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIFL--VDGSNSL--KLGDFGSAVKIQAHTTVPGELQGYVGTQAYMAPEVF---TKTNSDGHG--RAADIWSVGCVVVEMASGKRPWAQFDSNFQIMFKVGMGEKPQAP-----ESLSQEGHDFIDHCLQHDPKRRLTAVELLEHNFCK 1543
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Fly
Match: Mekk1 (gene:FBgn0024329 transcript:FBtr0331353)

HSP 1 Score: 185.267 bits (469), Expect = 1.455e-46
Identity = 117/327 (35.78%), Postives = 179/327 (54.74%), Query Frame = 3 
Query: 4071 KDRKRVTLKQAIVELENQLNEKRRQNNLMGFVRDSNSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDLI----ECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSIL--DIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHL---DGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEY-QHLAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVK 5021
            ++R R  + +  ++LE+ L E+R    L+G V+  NS +      +   F+W +   IGQG  G V+   N +T E+MAMKEI I    ++ L     E  +L  + H +L++Y+G+++    + IF E C  G+L  +  L  ++PE   R++T Q+L  +  LH H IVHRD+K  NIFL  ++G+N    KLGDFG A  +  H      L+   GT  YMAPEV    ++ N   HG     DIWS+GC+V+ M +GK PW ++  +  I + +GM + P  P       +++E  DFI  CL+ +P  RL A++LL  NF K
Sbjct: 1142 QERVRDAVNRLDMDLEDGLRERR----LIGQVKSLNSSDKVHIRARSVHFRWHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRALKNVAEELKILEGIKHKNLVRYYGIEVHREELLIFMELCSEGTLESLVELTGNLPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIFL--VDGSNSL--KLGDFGSAVKIQAHTTVPGELQGYVGTQAYMAPEVF---TKTNSDGHG--RAADIWSVGCVVVEMASGKRPWAQFDSNFQIMFKVGMGEKPQAP-----ESLSQEGHDFIDHCLQHDPKRRLTAVELLEHNFCK 1450
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Fly
Match: hpo (gene:FBgn0261456 transcript:FBtr0331920)

HSP 1 Score: 128.257 bits (321), Expect = 1.197e-29
Identity = 81/267 (30.34%), Postives = 131/267 (49.06%), Query Frame = 3 
Query: 4242 IGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSIL---DIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKLRNH 5033
            +G+G  G+V+K  + ++  I+A+K + +     + + E  ++ + +   +++Y+G       + I  EYC  GS+S +  L    + E  +       L+ +++LH  + +HRD+K  NI L N EG    +AKL DFGVA  L + +     + GT  +MAPEV          + GY+   DIWSLG   L M  GKPP+ E   +   + +  K  P     D   R + E  DF+  CL   PD+R  A +LL   F++   H
Sbjct:   48 LGEGSYGSVYKAVHKESSSIVAIKLVPVESDLHEIIKEISIMQQCDSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDIKAANILL-NTEG----YAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI--------EEIGYDCVADIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPD---RWSTEFIDFVSKCLVKEPDDRATATELLEHEFIRNAKH 298
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Fly
Match: hpo (gene:FBgn0261456 transcript:FBtr0086500)

HSP 1 Score: 128.257 bits (321), Expect = 1.197e-29
Identity = 81/267 (30.34%), Postives = 131/267 (49.06%), Query Frame = 3 
Query: 4242 IGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSIL---DIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKLRNH 5033
            +G+G  G+V+K  + ++  I+A+K + +     + + E  ++ + +   +++Y+G       + I  EYC  GS+S +  L    + E  +       L+ +++LH  + +HRD+K  NI L N EG    +AKL DFGVA  L + +     + GT  +MAPEV          + GY+   DIWSLG   L M  GKPP+ E   +   + +  K  P     D   R + E  DF+  CL   PD+R  A +LL   F++   H
Sbjct:   48 LGEGSYGSVYKAVHKESSSIVAIKLVPVESDLHEIIKEISIMQQCDSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDIKAANILL-NTEG----YAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI--------EEIGYDCVADIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPD---RWSTEFIDFVSKCLVKEPDDRATATELLEHEFIRNAKH 298
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Fly
Match: Ask1 (gene:FBgn0014006 transcript:FBtr0300256)

HSP 1 Score: 129.413 bits (324), Expect = 1.697e-29
Identity = 92/275 (33.45%), Postives = 136/275 (49.45%), Query Frame = 3 
Query: 4230 KKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDLI----ECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQV-----SILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEY--QHLAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVK 5021
            +K ++G+G  GTV+   +  T   +A+KE+   E  SQD+     E  L  +L H ++++Y G        +IF E   GGSLS +       L   E  +  ++KQILE + +LH   IVHRD+K DN+ +    G      K+ DFG +K L       +   GT+ YMAPEV       ++   GY    DIWS GC  + M TGKPP+ E    H A++     KK P IP       ++  A++FI+ C  I+  +R  A  LL   F++
Sbjct:  587 RKMVLGKGTYGTVYAARDKQTQVRIAIKEV--PEKNSQDVQPLHEEIKLHSQLRHRNIVRYLGSCSENGFFKIFMEQVPGGSLSDLLETKWGPLKDNESTMAFYSKQILEGLKYLHEQDIVHRDIKGDNVLVNTYSGV----VKISDFGTSKRLARINPMTETFTGTLQYMAPEVI------DQGVRGYGPAADIWSFGCTNVEMATGKPPFIELGSAHAAMFKVGFYKKHPNIP-----EELSANAKNFILRCFAISVMDRPSASQLLEDPFLQ 844
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Zebrafish
Match: map3k4 (mitogen-activated protein kinase kinase kinase 4 [Source:ZFIN;Acc:ZDB-GENE-990603-4])

HSP 1 Score: 253.062 bits (645), Expect = 2.778e-67
Identity = 267/1094 (24.41%), Postives = 470/1094 (42.96%), Query Frame = 3 
Query: 1923 LSLPPLLPHYLFLVKFPIKLMHCCIRKILGSPDISKISELSVITIKQRIIDFKDALQFTMRARQFLFDYTFGINFQINKFLASNSKDFAPKQDVDLSDFLSSSMKEIDGDLSSLLRHYIDCXXXXXXXXXXXXXXXXFEYGEPRKLLEEEWTFVKTYCHNIKQEEEIVASSFCNLAEYLFDLLQSRIESDYKLXXXXXXXXXXXXXXXXAEEDILSVSSINNRRMSKCCQTYNNKCKMIQSQLKQAADFSKMLRSDLEISIQLELNLNYSMNDLLSFLSLTKHKMIDLCSSDEQSSINPIDLTLIIPEESSSFIKELLDPLITGFSIHPKDDTVRTTLLNSSSSKPRCIKSREYILIINK---------KSKINWPGEKIKFIYQLDIGNLKQRIESSNIVFLARRPDELTEQLSHLLEFKIPSKHHNIQFKNVIQSCSEGQVEACHYNSKR-----TLNALKSKAIEIGQVLHN-------FFMYDKNDSFSVSELNKIQEETVRNSIKNSYSIIFEFYRDLIKLCTGDAFKTVLKNTIVGLLEKWFEFSRKFEPSEKGTVPRWANDGLNFLLQLCQSRVVMTMTKKEWHDFKKSIDNFVEFIVGKSNRHHXXXXXXXXXXXXXXXXXRSWLVTPKPDVIRGCENNASN------SKKIENWD---IKCDNRTLRSAFSEPSRMISSDQNSFPNQLDRHIDMKTPGNFNEISFTRSITVAEQGLEHS-----RDAPNSNKSTDGSSNE----------DHKDRKRVTLKQAIVELENQLNEKR----RQNNLMGFVRDS--NSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVI----NEPFSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLK----DIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQH-LAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKL 5024
            + LP   P +L L +  + ++H C++  L   +     E S+++IKQ + + K+ L+  +  +Q+   Y F +     + + ++ +      ++D          E + DL  +L  Y D ++  ++   +   +        + LLEEEW F K     I+  E      FC++A  L       +++  +         + +     AEE   + S    R + +  ++        + +  +A  F+KMLR DLEI+   E +L   ++ LL  L    +  + +   +E     P DLT     E    I +LL+      +   KD           S  P  I   E  L+++K          +   W G  +K + Q++  +  + ++  N++ +                  + S H   Q K   QS  E    +    S +      L  LK++A+++   +++        FM +       +E   +Q+   R ++   Y+  FE+++++++L +G+ F+  +    +    KW  F      S +GT PRWA  G +FL Q  ++  +  + + ++   +  ++  +  ++GK +         S  +S      R+   +P+P  +  C ++  N      S + E +    + CD   LR+    P     + ++   N+    I + T    + +S   +    +    HS     R+ P+  K+   SS              KD  R +  +A+       +EK     RQ N++G V ++  + DN     ++K  F+W +   IG+G  G V+   N+DT E+MAMKEI      ++   +   E  +   + H +L++Y GV++    M IF EYC+ G+L +VS L + E  +R ++KQI  AI  LH H IVHRD+K  NIFL     T+    KLGDFG +  L N+   +        GT  YMAPEV            G+    DIWSLGC+++ M+TGK PW EY+H   I Y +GM   P IP      +++ E +DF+  CL+  P  R  A  LL+  FVK+
Sbjct:  551 MDLPSFRPAFLVLCRVLLNVIHECLKLRL---EQRPAGEPSLLSIKQLVRECKEVLKGGLLMKQY---YQFML-----RGVVTDHQGLQTNANID----------EFEEDLHKMLEVYFDYMRSWIQMLQQLPQASH----SLKNLLEEEWNFTKVITPYIRGGEAQSGKLFCDIAGMLLKSTGEFLDAGLQ--------KSGNEFWECAEES--TASDEIRRSVIETSRSLKELFHEARERASKALGFAKMLRKDLEIAA--EFSLTSGVSSLLQALKNKNYVKVQIPGLEELQVFVPCDLT-----EQRLVILQLLN------AAAGKD----------CSKDPDEIPENEGYLLMSKHGVGDSNADGAWAEWDGTVLKLVPQMETVDTLRAMKVDNLLLVV-----------------MQSAHLVTQRKAFQQSMEELLSLSREQTSSQPLIVCALEQLKNEALQLCIKINDAIDRVEYMFMSEFEAEVEEAEKATLQQ-YYREAMIQGYNFAFEYHKEVVRLMSGE-FRRRIGERYIAFARKWMNFVLTKCESGRGTRPRWATQGFDFL-QAIEAAFISALPEDDFVSLQALMNECIGHVIGKPH---------SPVSSMYFAGPRN---SPRPVKVPRCHSDPPNPYLFIPSTQAEGFSSRSLPCD---LRTQLCVPGPR-PTGEHGHANKPSNDIRVSTGHENDRLSSVAAELQFKSLSRHSSPTEDREEPSYPKADPSSSARRSWELRNFISQSKDTARQSPLEAVRRSIQTFDEKHYALMRQRNIIGQVCNTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCINVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIRLYSKQITTAINVLHEHGIVHRDIKGANIFL-----TSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVIT-----RAKGEGHGRAADIWSLGCVLIEMVTGKRPWHEYEHNFQIMYRVGMGHKPPIP-----EKLSTEGKDFLAHCLESEPKRRWTASALLDHPFVKV 1535
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Zebrafish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:ZFIN;Acc:ZDB-GENE-070910-1])

HSP 1 Score: 146.362 bits (368), Expect = 1.647e-35
Identity = 98/286 (34.27%), Postives = 155/286 (54.20%), Query Frame = 3 
Query: 4212 APFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDL------IECD--LLCKLNHASLLKYHGV--DISLSHMRIFTEYCEGGSLS-QVSILDIPEINL-RQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVN---HLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKL 5024
            AP  W +  L+GQG  G V+   ++DT   +A K++  + P S +       +EC+  LL  L+H  +++Y+G   D +   + IF EY  GGS+  Q+        N+ R++T+QILE + +LHS+ IVHRD+K  NI L++  G    + KLGDFG +K L        G++ + GT  +M+PEV         S  GY  K D+WSLGC V+ M+T KPPW E++ +A  + +  +  P  P + S   +++  RDF+  C+ +    R  A +LL   F ++
Sbjct:  358 APVTWRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVHFD-PASPETSKEVSALECEIQLLKNLHHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANI-LRDSAG----NVKLGDFGASKRLQTICMSSTGVRSVTGTPYWMSPEVI--------SGEGYGRKADVWSLGCTVVEMLTEKPPWAEFEAMAAIFKIATQ--PTNPQLPS--HISEHTRDFLR-CIFVEAKYRPSAEELLRHPFSQI 624
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Zebrafish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:ZFIN;Acc:ZDB-GENE-070910-1])

HSP 1 Score: 145.976 bits (367), Expect = 1.710e-35
Identity = 98/286 (34.27%), Postives = 155/286 (54.20%), Query Frame = 3 
Query: 4212 APFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDL------IECD--LLCKLNHASLLKYHGV--DISLSHMRIFTEYCEGGSLS-QVSILDIPEINL-RQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVN---HLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKL 5024
            AP  W +  L+GQG  G V+   ++DT   +A K++  + P S +       +EC+  LL  L+H  +++Y+G   D +   + IF EY  GGS+  Q+        N+ R++T+QILE + +LHS+ IVHRD+K  NI L++  G    + KLGDFG +K L        G++ + GT  +M+PEV         S  GY  K D+WSLGC V+ M+T KPPW E++ +A  + +  +  P  P + S   +++  RDF+  C+ +    R  A +LL   F ++
Sbjct:  352 APVTWRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVHFD-PASPETSKEVSALECEIQLLKNLHHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANI-LRDSAG----NVKLGDFGASKRLQTICMSSTGVRSVTGTPYWMSPEVI--------SGEGYGRKADVWSLGCTVVEMLTEKPPWAEFEAMAAIFKIATQ--PTNPQLPS--HISEHTRDFLR-CIFVEAKYRPSAEELLRHPFSQI 618
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Zebrafish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:ZFIN;Acc:ZDB-GENE-070910-1])

HSP 1 Score: 145.206 bits (365), Expect = 3.106e-35
Identity = 98/288 (34.03%), Postives = 157/288 (54.51%), Query Frame = 3 
Query: 4212 APFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDL------IECD--LLCKLNHASLLKYHGV--DISLSHMRIFTEYCEGGSLS-QVSILDIPEINL-RQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAK-----CLVNHLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKL 5024
            AP  W +  L+GQG  G V+   ++DT   +A K++  + P S +       +EC+  LL  L+H  +++Y+G   D +   + IF EY  GGS+  Q+        N+ R++T+QILE + +LHS+ IVHRD+K  NI L++  G    + KLGDFG +K     C+ +   G++ + GT  +M+PEV         S  GY  K D+WSLGC V+ M+T KPPW E++ +A  + +  +  P  P + S   +++  RDF+  C+ +    R  A +LL   F ++
Sbjct:  340 APVTWRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVHFD-PASPETSKEVSALECEIQLLKNLHHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANI-LRDSAG----NVKLGDFGASKRLQTICMSS--TGVRSVTGTPYWMSPEVI--------SGEGYGRKADVWSLGCTVVEMLTEKPPWAEFEAMAAIFKIATQ--PTNPQLPS--HISEHTRDFLR-CIFVEAKYRPSAEELLRHPFSQI 606
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Zebrafish
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:ZFIN;Acc:ZDB-GENE-120215-96])

HSP 1 Score: 143.28 bits (360), Expect = 1.325e-34
Identity = 99/288 (34.38%), Postives = 149/288 (51.74%), Query Frame = 3 
Query: 4209 KAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDL------IECD--LLCKLNHASLLKYHGV--DISLSHMRIFTEYCEGGSLSQV--SILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAK-----CLVNHLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKKL-PFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFV 5018
            +AP  W    L+GQG  G VF   + DT   +A+K++  + P S +       +EC+  LL  L H  +++Y+G   D     + IF EY  GGS+     S   + E   R++T+QILE + +LHS+ IVHRD+K  NI L++  G    + KLGDFG ++     CL     G+K + GT  +M+PEV         S  GY  K DIWS+GC V+ M+T +PPW E++ +A  + +  +   P +P       ++   RDF+     +   +R  A DLL   FV
Sbjct:  357 RAPTNWRLGKLLGQGAFGRVFLCYDADTGRELAVKQVQFD-PDSPETSKEVSALECEIQLLKNLFHERIVQYYGCLRDTHEKTLSIFMEYMPGGSIKDQLKSYGALTENVTRKYTRQILEGVCYLHSNMIVHRDIKGANI-LRDSAG----NVKLGDFGASRRLQTICLSG--TGIKSVTGTPYWMSPEVI--------SGEGYGRKADIWSIGCTVVEMLTQRPPWAEFEAMAAIFKIATQPTNPTLP-----PHVSDHCRDFLKRIF-VETKQRPAAEDLLRHTFV 622
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Xenopus
Match: ephb1 (EPH receptor B1 [Source:Xenbase;Acc:XB-GENE-488626])

HSP 1 Score: 256.144 bits (653), Expect = 4.245e-68
Identity = 264/1085 (24.33%), Postives = 458/1085 (42.21%), Query Frame = 3 
Query: 1923 LSLPPLLPHYLFLVKFPIKLMHCCIRKILGSPDISKISELSVITIKQRIIDFKDALQFTMRARQFLFDYTFGINFQINKFLASNSKDFAPKQDVDLSDFLSSSMKEIDGDLSSLLRHYIDCXXXXXXXXXXXXXXXXFEYGEPRKLLEEEWTFVKTYCHNIKQEEEIVASSFCNLAEYLFDLLQSRIESDYKLXXXXXXXXXXXXXXXXAEEDILSVSSINNRRMSKCCQTYNNKCKMIQSQLKQAADFSKMLRSDLEISIQLELNLNYSMNDLLSFLSLTKHKMIDLCSSDEQSSINPIDLTLIIPEESSS---FIKELLDPLITGFSIHPKDDTVRTTLLNSSSSKPRCIKSREYILIINKKSKI-------NWPGEKIKFIYQLDIGNLKQRIESSNIVFLARRPDELTEQLSHLLEFKIPSKHHNIQFKNVIQSCSEG------QVEACHYNSKRTLNALKSKAIEIGQVLHN-------FFMYDKNDSFSVSELNKIQEETVRNSIKNSYSIIFEFYRDLIKLCTGDAFKTVLKNTIVGLLEKWFEFSRKFEPSEKGTVPRWANDGLNFLLQLCQSRVVMTMTKKEWHDFKKSIDNFVEFIVGKSNR----HHXXXXXXXXXXXXXXXXXRSWLVTPKPDVIR------GCENNASNSKKIENWDIKCDNRTLRSAFSEPSRMISSDQNSFPNQLDRHI----DMKTPG--NFNEISFTRSITVAEQGLEHSRDAPNSNKSTDGSSNEDHKDRKRVTLKQAIVELENQLNEKRRQNNLMGFVRDS--NSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDLI-----ECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGL----KDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQH-LAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKL 5024
            + LP  LP +L L +  + ++H C++  L   +     E S+++IKQ + + K+ L+  +  +Q+             +F+     D   K D D+  F        + DL  +L  Y D ++  ++   +   +        + LLEEEW F K     I+  E      FC++A  L       ++S             DS     A  D  S+S    R + +  +         + +  +A  F+KMLR DLEI+   E     ++ +LL+FL    +  + + S +        +L + IP   S     +++LL    T   I    D                +   +++L+     K        +W G  IK +  ++  +  + +++ N++ +  +   L  Q                  +   Q  +EG      +  + H      L  LKS+A+++   + +        F  +       SE + +Q+   R ++   Y+  FE+++++++L +G+ F+    +  +    KW  F      S +GT PRWA  G ++L Q  +   +  + + ++   +  ++  +  ++GK +      H  +                 L+TP P+  R      G      + +K+     +C N  L S+  E  R+ S         L RH     D + P          TR     +  +  +RD    ++  +              +++++ + E++   + R  N++G V D+  + DN     ++K  F+W +   IG+G  G V+   ++DT E+MAMKEI   +P     I     E  +   + H +L++Y GV++    M IF EYC+ G+L +VS L + E  +R +TKQI  AI  LH H IVHRD+K  NIFL     T+    KLGDFG +  L N+   +        GT  YMAPEV      Q K + G+    DIWSLGC+++ M+TGK PW EY+H   I Y +GM   P IP      R++ E +DF+  C + +P  R  A  LL+  FVK+
Sbjct:  564 MDLPSFLPAFLVLCRVLLNVIHECLKLRL---EQRPAGEPSLLSIKQLVRECKEVLKGGLLMKQYY------------QFMLREVLDDLQKLDCDIDSF--------EDDLHKMLMVYFDYMRSWIQMLQQLPQASH----SLKNLLEEEWNFTKEITPLIRGGEAQAGKLFCDIAGMLLKSTGKFLDSGL----------LDSCDEFWASTDDSSISDEIRRSVIETSRALKELFHEARERASKALGFAKMLRKDLEIAA--EFTFASTILELLAFLKAKDYAKVLIPSVE--------NLHVFIPGNLSREKIIVQQLLG---TAAGIDCSKDC-------------EDMAYDQFLLMTKHIDKDKPQEDWNSWDGCCIKSMPPVETADTLRSMQTDNLLLVVMQSAHLQSQ------------------RKAFQHSTEGLLSLRLEQTSSHPMIAEALFQLKSEALQLCNEISSAIDRVDKMFTNESEAEIDESESSTLQQ-YYREAMIQGYNFGFEYHKEVVRLMSGE-FRQKTGDKYINFARKWMNFVLTKCESGRGTRPRWATQGFDYL-QAIEPVFISALPEDDFLSLQALMNECIGHVIGKPHSPVTATHRNSPRPVKVPRCHSDPPNPNLITPTPEGFRYKPFDAGFAQAEISHRKLSTLPQRCVNAALGSSVPENDRLASVASELQFRSLSRHSSPTEDREEPSYPKGELWGSTRRSWELQTFISQTRDIAARHRPMNA-------------IQESVKQFEDERYRQMRNKNIVGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISIDTGELMAMKEIRF-QPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIRLYTKQITIAINVLHEHGIVHRDIKGANIFL-----TSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVIT----QAKGE-GHGRAADIWSLGCVLIEMVTGKRPWHEYEHNFQIMYRVGMGHKPPIP-----DRLSPEGKDFLSHCQESDPKMRWTASQLLDHAFVKV 1535
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Xenopus
Match: ephb1 (EPH receptor B1 [Source:Xenbase;Acc:XB-GENE-488626])

HSP 1 Score: 249.595 bits (636), Expect = 3.957e-66
Identity = 258/1074 (24.02%), Postives = 457/1074 (42.55%), Query Frame = 3 
Query: 1923 LSLPPLLPHYLFLVKFPIKLMHCCIRKILGSPDISKISELSVITIKQRIIDFKDALQFTMRARQFLFDYTFGINFQINKFLASNSKDFAPKQDVDLSDFLSSSMKEIDGDLSSLLRHYIDCXXXXXXXXXXXXXXXXFEYGEPRKLLEEEWTFVKTYCHNIKQEEEIVASSFCNLAEYLFDLLQSRIESDYKLXXXXXXXXXXXXXXXXAEEDILSVSSINNRRMSKCCQTYNNKCKMIQSQLKQAADFSKMLRSDLEISIQLELNLNYSMNDLLSFLSLTKHKMIDLCSSDEQSSINPIDLTLIIPEESSSFIKELLDPLITGFSIHPKDDTVRTTLLNSSSSKPRCIKSREYILIINKKSKI-------NWPGEKIKFIYQLDIGNLKQRIESSNIVFLARRPDELTEQLSHLLEFKIPSKHHNIQFKNVIQSCSEG------QVEACHYNSKRTLNALKSKAIEIGQVLHN-------FFMYDKNDSFSVSELNKIQEETVRNSIKNSYSIIFEFYRDLIKLCTGDAFKTVLKNTIVGLLEKWFEFSRKFEPSEKGTVPRWANDGLNFLLQLCQSRVVMTMTKKEWHDFKKSIDNFVEFIVGKSNR----HHXXXXXXXXXXXXXXXXXRSWLVTPKPDVIRGCENNASNSKKIENWDIKCDNRTLRSAFSEPSRMISSDQNSFP-----NQLDRHIDMKTPGNFNEISFTRSITVAEQGLEHSRDAPNSNKSTDGSSNEDHKDRKRVTLKQAIVELENQLNEKRRQNNLMGFVRDS--NSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVI----NEPFSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGL----KDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQH-LAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKL 5024
            + LP  LP +L L +  + ++H C++  L   +     E S+++IKQ + + K+ L+  +  +Q+             +F+     D   K D D+  F        + DL  +L  Y D ++  ++   +   +        + LLEEEW F K     I+  E      FC++A  L       ++S             DS     A  D  S+S    R + +  +         + +  +A  F+KMLR DLEI+   E     ++ +LL+FL    +  + + S +      P +L+          +++LL    T   I    D                +   +++L+     K        +W G  IK +  ++  +  + +++ N++ +  +   L  Q                  +   Q  +EG      +  + H      L  LKS+A+++   + +        F  +       SE + +Q+   R ++   Y+  FE+++++++L +G+ F+    +  +    KW  F      S +GT PRWA  G ++L Q  +   +  + + ++   +  ++  +  ++GK +      H  +                 L+TP P+  RG  ++   + ++ +   +   R+L S  S P+     ++ S+P         R  +++T      IS TR I                            + R    +++++ + E++   + R  N++G V D+  + DN     ++K  F+W +   IG+G  G V+   ++DT E+MAMKEI      ++   +   E  +   + H +L++Y GV++    M IF EYC+ G+L +VS L + E  +R +TKQI  AI  LH H IVHRD+K  NIFL     T+    KLGDFG +  L N+   +        GT  YMAPEV      Q K + G+    DIWSLGC+++ M+TGK PW EY+H   I Y +GM   P IP      R++ E +DF+  C + +P  R  A  LL+  FVK+
Sbjct:  488 MDLPSFLPAFLVLCRVLLNVIHECLKLRL---EQRPAGEPSLLSIKQLVRECKEVLKGGLLMKQYY------------QFMLREVLDDLQKLDCDIDSF--------EDDLHKMLMVYFDYMRSWIQMLQQLPQASH----SLKNLLEEEWNFTKEITPLIRGGEAQAGKLFCDIAGMLLKSTGKFLDSGL----------LDSCDEFWASTDDSSISDEIRRSVIETSRALKELFHEARERASKALGFAKMLRKDLEIAA--EFTFASTILELLAFLKAKDYAKVLIPSVENLHVFIPGNLS-----REKIIVQQLLG---TAAGIDCSKDC-------------EDMAYDQFLLMTKHIDKDKPQEDWNSWDGCCIKSMPPVETADTLRSMQTDNLLLVVMQSAHLQSQ------------------RKAFQHSTEGLLSLRLEQTSSHPMIAEALFQLKSEALQLCNEISSAIDRVDKMFTNESEAEIDESESSTLQQ-YYREAMIQGYNFGFEYHKEVVRLMSGE-FRQKTGDKYINFARKWMNFVLTKCESGRGTRPRWATQGFDYL-QAIEPVFISALPEDDFLSLQALMNECIGHVIGKPHSPVTATHRNSPRPVKVPRCHSDPPNPNLITPTPEGFRG--SSVPENDRLASVASELQFRSL-SRHSSPTE--DREEPSYPKGELWGSTRRSWELQT-----FISQTRDIAA--------------------------RHRPMNAIQESVKQFEDERYRQMRNKNIVGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISIDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIRLYTKQITIAINVLHEHGIVHRDIKGANIFL-----TSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVIT----QAKGE-GHGRAADIWSLGCVLIEMVTGKRPWHEYEHNFQIMYRVGMGHKPPIP-----DRLSPEGKDFLSHCQESDPKMRWTASQLLDHAFVKV 1429
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Xenopus
Match: ephb1 (EPH receptor B1 [Source:Xenbase;Acc:XB-GENE-488626])

HSP 1 Score: 225.713 bits (574), Expect = 7.863e-59
Identity = 212/834 (25.42%), Postives = 367/834 (44.00%), Query Frame = 3 
Query: 2655 QAADFSKMLRSDLEISIQLELNLNYSMNDLLSFLSLTKHKMIDLCSSDEQSSINPIDLTLIIPEESSS---FIKELLDPLITGFSIHPKDDTVRTTLLNSSSSKPRCIKSREYILIINKKSKI-------NWPGEKIKFIYQLDIGNLKQRIESSNIVFLARRPDELTEQLSHLLEFKIPSKHHNIQFKNVIQSCSEG------QVEACHYNSKRTLNALKSKAIEIGQVLHN-------FFMYDKNDSFSVSELNKIQEETVRNSIKNSYSIIFEFYRDLIKLCTGDAFKTVLKNTIVGLLEKWFEFSRKFEPSEKGTVPRWANDGLNFLLQLCQSRVVMTMTKKEWHDFKKSIDNFVEFIVGKSNR----HHXXXXXXXXXXXXXXXXXRSWLVTPKPDVIRGCENNASNSKKIENWDIKCDNRTLRSAFSEPSRMISSDQNSFP-----NQLDRHIDMKTPGNFNEISFTRSITVAEQGLEHSRDAPNSNKSTDGSSNEDHKDRKRVTLKQAIVELENQLNEKRRQNNLMGFVRDS--NSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDLI-----ECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLK----DIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQH-LAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKL 5024
            +A  F+KMLR DLEI+   E     ++ +LL+FL    +  + + S +        +L + IP   S     +++LL    T   I    D                +   +++L+     K        +W G  IK +  ++  +  + +++ N++ +  +   L  Q                  +   Q  +EG      +  + H      L  LKS+A+++   + +        F  +       SE + +Q+   R ++   Y+  FE+++++++L +G+ F+    +  +    KW  F      S +GT PRWA  G ++L Q  +   +  + + ++   +  ++  +  ++GK +      H  +                 L+TP P+  RG  ++   + ++ +   +   R+L S  S P+     ++ S+P         R  +++T      IS TR I                            + R    +++++ + E++   + R  N++G V D+  + DN     ++K  F+W +   IG+G  G V+   ++DT E+MAMKEI   +P     I     E  +   + H +L++Y GV++    M IF EYC+ G+L +VS L + E  +R +TKQI  AI  LH H IVHRD+K  NIFL     T+    KLGDFG +  L N+   +        GT  YMAPEV      Q K + G+    DIWSLGC+++ M+TGK PW EY+H   I Y +GM   P IP      R++ E +DF+  C + +P  R  A  LL+  FVK+
Sbjct:  654 KALGFAKMLRKDLEIAA--EFTFASTILELLAFLKAKDYAKVLIPSVE--------NLHVFIPGNLSREKIIVQQLLG---TAAGIDCSKDC-------------EDMAYDQFLLMTKHIDKDKPQEDWNSWDGCCIKSMPPVETADTLRSMQTDNLLLVVMQSAHLQSQ------------------RKAFQHSTEGLLSLRLEQTSSHPMIAEALFQLKSEALQLCNEISSAIDRVDKMFTNESEAEIDESESSTLQQ-YYREAMIQGYNFGFEYHKEVVRLMSGE-FRQKTGDKYINFARKWMNFVLTKCESGRGTRPRWATQGFDYL-QAIEPVFISALPEDDFLSLQALMNECIGHVIGKPHSPVTATHRNSPRPVKVPRCHSDPPNPNLITPTPEGFRG--SSVPENDRLASVASELQFRSL-SRHSSPTE--DREEPSYPKGELWGSTRRSWELQT-----FISQTRDIAA--------------------------RHRPMNAIQESVKQFEDERYRQMRNKNIVGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISIDTGELMAMKEIRF-QPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIRLYTKQITIAINVLHEHGIVHRDIKGANIFL-----TSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVIT----QAKGE-GHGRAADIWSLGCVLIEMVTGKRPWHEYEHNFQIMYRVGMGHKPPIP-----DRLSPEGKDFLSHCQESDPKMRWTASQLLDHAFVKV 1388
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Xenopus
Match: ephb1 (EPH receptor B1 [Source:Xenbase;Acc:XB-GENE-488626])

HSP 1 Score: 206.068 bits (523), Expect = 1.168e-52
Identity = 163/549 (29.69%), Postives = 255/549 (46.45%), Query Frame = 3 
Query: 3480 VGLLEKWFEFSRKFEPSEKGTVPRWANDGLNFLLQLCQSRVVMTMTKKEWHDFKKSIDNFVEFIVGKSNR--------HHXXXXXXXXXXXXXXXXXRSWLVTPKPDVIRGCENNASNSKKIENWDIKCDNRTLRSAFSEPSRMISSDQNSFPNQLDRHIDMKTPGNFNEISFTRSITVAEQGLEHSRDAPNSNKS-------------TDGSSNEDHKDRKRV--TLKQAIVELENQLNEKRRQNNLMGFVRDS--NSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVI----NEPFSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLK----DIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQH-LAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKL 5024
            +    KW  F      S +GT PRWA  G ++L Q  +   +  + + ++   +  ++  +  ++GK +          H  +                 L+TP P+  R    +A  ++       +  +R L S   +P+   SS  +S P   DR   + +   F  +S   S T         R+ P+  K              T  S   D   R R    +++++ + E++   + R  N++G V D+  + DN     ++K  F+W +   IG+G  G V+   ++DT E+MAMKEI      ++   +   E  +   + H +L++Y GV++    M IF EYC+ G+L +VS L + E  +R +TKQI  AI  LH H IVHRD+K  NIFL     T+    KLGDFG +  L N+   +        GT  YMAPEV      Q K + G+    DIWSLGC+++ M+TGK PW EY+H   I Y +GM   P IP      R++ E +DF+  C + +P  R  A  LL+  FVK+
Sbjct: 1022 INFARKWMNFVLTKCESGRGTRPRWATQGFDYL-QAIEPVFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGLYIATHRNSPRPVKVPRCHSDPPNPNLITPTPEGFRYKPFDAGFAQA------EISHRKL-STLPQPT---SSRGSSVPEN-DRLASVASELQFRSLSRHSSPT-------EDREEPSYPKGELWGSTRRSWELQTFISQTRDIAARHRPMNAIQESVKQFEDERYRQMRNKNIVGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISIDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIRLYTKQITIAINVLHEHGIVHRDIKGANIFL-----TSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVIT----QAKGE-GHGRAADIWSLGCVLIEMVTGKRPWHEYEHNFQIMYRVGMGHKPPIP-----DRLSPEGKDFLSHCQESDPKMRWTASQLLDHAFVKV 1536
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Xenopus
Match: ephb1 (EPH receptor B1 [Source:Xenbase;Acc:XB-GENE-488626])

HSP 1 Score: 204.912 bits (520), Expect = 2.415e-52
Identity = 161/551 (29.22%), Postives = 255/551 (46.28%), Query Frame = 3 
Query: 3480 VGLLEKWFEFSRKFEPSEKGTVPRWANDGLNFLLQLCQSRVVMTMTKKEWHDFKKSIDNFVEFIVGKSNR--------HHXXXXXXXXXXXXXXXXXRSWLVTPKPDVIRGCENNASNSKKIENWDIKCDNRTLRSAFSEP--SRMISSDQNSFPNQLDRHIDMKTPGNFNEISFTRSITVAEQGLEHSRDAPNSNKS-------------TDGSSNEDHKDRKRV--TLKQAIVELENQLNEKRRQNNLMGFVRDS--NSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVI----NEPFSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLK----DIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQH-LAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKL 5024
            +    KW  F      S +GT PRWA  G ++L Q  +   +  + + ++   +  ++  +  ++GK +          H  +                 L+TP P+  R    +A   +        C++ +++   S+P  SR+      S   + DR   + +   F  +S   S T         R+ P+  K              T  S   D   R R    +++++ + E++   + R  N++G V D+  + DN     ++K  F+W +   IG+G  G V+   ++DT E+MAMKEI      ++   +   E  +   + H +L++Y GV++    M IF EYC+ G+L +VS L + E  +R +TKQI  AI  LH H IVHRD+K  NIFL     T+    KLGDFG +  L N+   +        GT  YMAPEV      Q K + G+    DIWSLGC+++ M+TGK PW EY+H   I Y +GM   P IP      R++ E +DF+  C + +P  R  A  LL+  FVK+
Sbjct: 1018 INFARKWMNFVLTKCESGRGTRPRWATQGFDYL-QAIEPVFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGLYIATHRNSPRPVKVPRCHSDPPNPNLITPTPEGFRYKPFDAGFPQATH-----CNSCSVK-GLSQPTSSRLAVVSVGSSVPENDRLASVASELQFRSLSRHSSPT-------EDREEPSYPKGELWGSTRRSWELQTFISQTRDIAARHRPMNAIQESVKQFEDERYRQMRNKNIVGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISIDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIRLYTKQITIAINVLHEHGIVHRDIKGANIFL-----TSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVIT----QAKGE-GHGRAADIWSLGCVLIEMVTGKRPWHEYEHNFQIMYRVGMGHKPPIP-----DRLSPEGKDFLSHCQESDPKMRWTASQLLDHAFVKV 1539
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Mouse
Match: Map3k4 (mitogen-activated protein kinase kinase kinase 4 [Source:MGI Symbol;Acc:MGI:1346875])

HSP 1 Score: 241.121 bits (614), Expect = 1.543e-63
Identity = 233/924 (25.22%), Postives = 400/924 (43.29%), Query Frame = 3 
Query: 2352 RKLLEEEWTFVKTYCHNIKQEEEIVASSFCNLAEYLFDLLQSRIESDYKLXXXXXXXXXXXXXXXXAEEDILSVSSINNRRMSKCCQTYNNKCKMIQSQLKQAADFSKMLRSDLEISIQLELNLNYSMNDLLSFLSLTKHKMIDLCSSDEQSSINPIDLTLIIPE---ESSSFIKELLDPLITGFSIHPKDDTVRTTLLNSSSSKPRCIKSREYILIINKKSKINWPGEKIKFIYQLDIGNLKQRIESSNIVFLARRPDELTEQLSHLLEFKIPSKHHNIQFKNVIQSCSEGQVEACHYNS------KRTLNALKSKAIEIGQVLHNFFMYDKNDSFSVSELNKIQEET--------VRNSIKNSYSIIFEFYRDLIKLCTGDAFKTVLKNTIVGLLEKWFEFSRKFEPSEKGTVPRWANDGLNFLLQLCQSRVVMTMTKKEWHDFKKSIDNFVEFIVGKSNRH----HXXXXXXXXXXXXXXXXXRSWLVTPKPDVIRGCENNASNSKKIENWDIKCDNRTLRSAFSEPSRMISSDQNSFPNQLDRHIDMKTPGNFNEISFTRSITVAEQGLEHSRDAPNSNKSTDGSSNEDHKDRKRVTLKQAIVELENQLNEKRRQNNLMGFVRDS--NSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDLI-----ECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLK----DIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQH-LAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKL 5024
            + LLEEEW F K   H I+  E      FC++A  L     S +ES   L          +     A+E   SV  I     S+  +   ++ +    +  +A  F+KMLR DLEI+   E  L+ S  +LL  L   ++  + +   +        +L + +P+   E    I +LL+           DD      L  +    R   S +            W    +K + Q++  +  + ++  N++ +                  + S H  +Q K   QS  EG +   H  +       + L  LK+ A+E+   + +    D+ D     E +   EE+         R ++   Y+  FE+++++++L +G+ F+  + +  +   +KW  +      S +GT PRWA  G +FL Q  +   +  + + ++   +  ++  +  ++GK +      H  +                 L+ P P+  RG  ++   + ++ +   +   R+L S  S P+     D+ ++P          + G+       R++      +  ++D+ +     +              +++++   E +   + R+ N++G V D+  + DN     ++K  F+W +   IG+G  G V+   ++DT E+MAMKEI   +P     I     E  +   + H +L++Y GV++    M IF EYC+ G+L +VS L + E  +R +TKQI  AI  LH H IVHRD+K  NIFL     T+    KLGDFG +  L N+   +        GT  YMAPEV            G+    DIWSLGC+V+ M+TGK PW EY+H   I Y +GM   P IP      R++ E + F+  CL+ +P  R  A  LL+  FVK+
Sbjct:  714 KNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLESG--LQESCAELWTSADDNGAADELRRSVIEI-----SRALKELFHEAR---ERASKALGFAKMLRKDLEIAA--EFVLSASARELLDALKAKQYVKVQIPGLE--------NLHVFVPDSLAEEKKIILQLLNAATGKDCSKDPDDVFMDAFLLLTKHGDRARDSED--------GWGTWEARAVKIVPQVETVDTLRSMQVDNLLLVV-----------------MESAHLVLQRKAFQQSI-EGLMTVRHEQTSSQPIIAKGLQQLKNDALELCNRISDAI--DRVDHMFTLEFDAEVEESESATLQQYYREAMIQGYNFGFEYHKEVVRLMSGE-FRQKIGDKYISFAQKWMNYVLTKCESGRGTRPRWATQGFDFL-QAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTAIHRNSPRPVKVPRCHSDPPNPHLIIPTPEGFRG--SSVPENDRLASIAAELQFRSL-SRHSSPTE--ERDEPAYPRS-------DSSGSTRRSWELRTL------ISQTKDSASKQGPIEA-------------IQKSVRLFEERRYREMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRF-QPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIRLYTKQITVAINVLHEHGIVHRDIKGANIFL-----TSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVIT-----RAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIP-----ERLSPEGKAFLSHCLESDPKIRWTASQLLDHAFVKV 1540
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Mouse
Match: Map3k4 (mitogen-activated protein kinase kinase kinase 4 [Source:MGI Symbol;Acc:MGI:1346875])

HSP 1 Score: 193.741 bits (491), Expect = 5.761e-49
Identity = 118/304 (38.82%), Postives = 164/304 (53.95%), Query Frame = 3 
Query: 4149 NLMGFVRDS--NSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDLI-----ECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLK----DIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQH-LAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKL 5024
            N++G V D+  + DN     ++K  F+W +   IG+G  G V+   ++DT E+MAMKEI   +P     I     E  +   + H +L++Y GV++    M IF EYC+ G+L +VS L + E  +R +TKQI  AI  LH H IVHRD+K  NIFL     T+    KLGDFG +  L N+   +        GT  YMAPEV            G+    DIWSLGC+V+ M+TGK PW EY+H   I Y +GM   P IP      R++ E + F+  CL+ +P  R  A  LL+  FVK+
Sbjct: 1305 NIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRF-QPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIRLYTKQITVAINVLHEHGIVHRDIKGANIFL-----TSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVIT-----RAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIP-----ERLSPEGKAFLSHCLESDPKIRWTASQLLDHAFVKV 1592

HSP 2 Score: 75.0998 bits (183), Expect = 9.990e-13
Identity = 97/462 (21.00%), Postives = 185/462 (40.04%), Query Frame = 3 
Query: 2352 RKLLEEEWTFVKTYCHNIKQEEEIVASSFCNLAEYLFDLLQSRIESDYKLXXXXXXXXXXXXXXXXAEEDILSVSSINNRRMSKCCQTYNNKCKMIQSQLKQAADFSKMLRSDLEISIQLELNLNYSMNDLLSFLSLTKHKMIDLCSSDEQSSINPIDLTLIIPE---ESSSFIKELLDPLITGFSIHPKDDTVRTTLLNSSSSKPRCIKSREYILIINKKSKINWPGEKIKFIYQLDIGNLKQRIESSNIVFLARRPDELTEQLSHLLEFKIPSKHHNIQFKNVIQSCSEGQVEACHYNS------KRTLNALKSKAIEIGQVLHNFFMYDKNDSFSVSELNKIQEET--------VRNSIKNSYSIIFEFYRDLIKLCTGDAFKTVLKNTIVGLLEKWFEFSRKFEPSEKGTVPRWANDGLNFLLQLCQSRVVMTMTKKEWHDFKKSIDNFVEFIVGKSN 3686
            + LLEEEW F K   H I+  E      FC++A  L     S +ES   L          +     A+E   SV  I     S+  +   ++ +    +  +A  F+KMLR DLEI+   E  L+ S  +LL  L   ++  + +   +        +L + +P+   E    I +LL+           DD      L  +    R   S +            W    +K + Q++  +  + ++  N++ +                  + S H  +Q K   QS  EG +   H  +       + L  LK+ A+E+   + +    D+ D     E +   EE+         R ++   Y+  FE+++++++L +G+ F+  + +  +   +KW  +      S +GT PRWA  G +F LQ  +   +  + + ++   +  ++  +  ++GK +
Sbjct:  714 KNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLESG--LQESCAELWTSADDNGAADELRRSVIEI-----SRALKELFHEAR---ERASKALGFAKMLRKDLEIAA--EFVLSASARELLDALKAKQYVKVQIPGLE--------NLHVFVPDSLAEEKKIILQLLNAATGKDCSKDPDDVFMDAFLLLTKHGDRARDSED--------GWGTWEARAVKIVPQVETVDTLRSMQVDNLLLVV-----------------MESAHLVLQRKAFQQSI-EGLMTVRHEQTSSQPIIAKGLQQLKNDALELCNRISDAI--DRVDHMFTLEFDAEVEESESATLQQYYREAMIQGYNFGFEYHKEVVRLMSGE-FRQKIGDKYISFAQKWMNYVLTKCESGRGTRPRWATQGFDF-LQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPH 1125
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Mouse
Match: Map3k19 (mitogen-activated protein kinase kinase kinase 19 [Source:MGI Symbol;Acc:MGI:1203481])

HSP 1 Score: 150.599 bits (379), Expect = 1.443e-37
Identity = 95/285 (33.33%), Postives = 152/285 (53.33%), Query Frame = 3 
Query: 4224 WIKKGLIGQGHAGTVFKVCNLDTM-EIMAMKEIVIN--------EPFSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQV--SILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLV------NHLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKK--LPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVK 5021
            W K  ++G+G  GTV+  C L ++ +++A+K++ ++        + + +   E DLL  L H +++ Y G  +  + + IF E+  GGS+S +      +PE+   ++T+QIL+ + +LH + +VHRD+K +N+ L           KL DFG AK L        H D LK ++GT  +MAPEV         ++ GY  K DIWS+GC V  M TGKPP      +A  + +G  +  +P +P     AR ++ A DF+  CL  +  ER  AL LL  +F+K
Sbjct:  248 WTKGEILGRGAYGTVY--CGLTSLGQLIAVKQVALDTSDKLATEKEYRKLQEEVDLLKALKHVNIVAYLGTCLEENTLSIFMEFVPGGSISSIINRFGPLPEMVFCKYTRQILQGVAYLHDNCVVHRDIKGNNVMLMPTG-----IIKLIDFGCAKRLAWAGLNGTHSDMLKSMRGTPYWMAPEVI--------NESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLP-----ARFSEPAADFVRLCLTRDQHERPSALQLLKHSFLK 512
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Mouse
Match: Map3k19 (mitogen-activated protein kinase kinase kinase 19 [Source:MGI Symbol;Acc:MGI:1203481])

HSP 1 Score: 152.91 bits (385), Expect = 1.349e-36
Identity = 95/285 (33.33%), Postives = 152/285 (53.33%), Query Frame = 3 
Query: 4224 WIKKGLIGQGHAGTVFKVCNLDTM-EIMAMKEIVIN--------EPFSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQV--SILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLV------NHLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKK--LPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVK 5021
            W K  ++G+G  GTV+  C L ++ +++A+K++ ++        + + +   E DLL  L H +++ Y G  +  + + IF E+  GGS+S +      +PE+   ++T+QIL+ + +LH + +VHRD+K +N+ L           KL DFG AK L        H D LK ++GT  +MAPEV         ++ GY  K DIWS+GC V  M TGKPP      +A  + +G  +  +P +P     AR ++ A DF+  CL  +  ER  AL LL  +F+K
Sbjct: 1044 WTKGEILGRGAYGTVY--CGLTSLGQLIAVKQVALDTSDKLATEKEYRKLQEEVDLLKALKHVNIVAYLGTCLEENTLSIFMEFVPGGSISSIINRFGPLPEMVFCKYTRQILQGVAYLHDNCVVHRDIKGNNVMLMPT-----GIIKLIDFGCAKRLAWAGLNGTHSDMLKSMRGTPYWMAPEVI--------NESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLP-----ARFSEPAADFVRLCLTRDQHERPSALQLLKHSFLK 1308
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Mouse
Match: Map3k19 (mitogen-activated protein kinase kinase kinase 19 [Source:MGI Symbol;Acc:MGI:1203481])

HSP 1 Score: 152.525 bits (384), Expect = 1.693e-36
Identity = 95/285 (33.33%), Postives = 152/285 (53.33%), Query Frame = 3 
Query: 4224 WIKKGLIGQGHAGTVFKVCNLDTM-EIMAMKEIVIN--------EPFSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQV--SILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLV------NHLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKK--LPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVK 5021
            W K  ++G+G  GTV+  C L ++ +++A+K++ ++        + + +   E DLL  L H +++ Y G  +  + + IF E+  GGS+S +      +PE+   ++T+QIL+ + +LH + +VHRD+K +N+ L           KL DFG AK L        H D LK ++GT  +MAPEV         ++ GY  K DIWS+GC V  M TGKPP      +A  + +G  +  +P +P     AR ++ A DF+  CL  +  ER  AL LL  +F+K
Sbjct:  944 WTKGEILGRGAYGTVY--CGLTSLGQLIAVKQVALDTSDKLATEKEYRKLQEEVDLLKALKHVNIVAYLGTCLEENTLSIFMEFVPGGSISSIINRFGPLPEMVFCKYTRQILQGVAYLHDNCVVHRDIKGNNVMLMPT-----GIIKLIDFGCAKRLAWAGLNGTHSDMLKSMRGTPYWMAPEVI--------NESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLP-----ARFSEPAADFVRLCLTRDQHERPSALQLLKHSFLK 1208
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. UniProt/SwissProt
Match: sp|Q9Y6R4|M3K4_HUMAN (Mitogen-activated protein kinase kinase kinase 4 OS=Homo sapiens OX=9606 GN=MAP3K4 PE=1 SV=2)

HSP 1 Score: 200.29 bits (508), Expect = 4.543e-50
Identity = 118/323 (36.53%), Postives = 176/323 (54.49%), Query Frame = 3 
Query: 4089 TLKQAIVELENQLNEKRRQNNLMGFVRDS--NSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVI----NEPFSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLK----DIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQH-LAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKL 5024
             +++++   E +   + R+ N++G V D+  + DN     ++K  F+W +   IG+G  G V+   ++DT E+MAMKEI      ++   +   E  +   + H +L++Y GV++    M IF EYC+ G+L +VS L + E  +R ++KQI  AI  LH H IVHRD+K  NIFL     T+    KLGDFG +  L N+   +        GT  YMAPEV            G+    DIWSLGC+V+ M+TGK PW EY+H   I Y +GM   P IP      R++ E +DF+  CL+ +P  R  A  LL+ +FVK+
Sbjct: 1296 AIQKSVRLFEEKRYREMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFL-----TSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVIT-----RAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIP-----ERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKV 1603

HSP 2 Score: 93.5893 bits (231), Expect = 1.411e-17
Identity = 125/605 (20.66%), Postives = 247/605 (40.83%), Query Frame = 3 
Query: 1923 LSLPPLLPHYLFLVKFPIKLMHCCIRKILGSPDISKISELSVITIKQRIIDFKDALQFTMRARQFLFDYTFGINFQINKFLASNSKDFAPKQDVDLSDFLSSSMKEIDGDLSSLLRHYIDCXXXXXXXXXXXXXXXXFEYGEPRKLLEEEWTFVKTYCHNIKQEEEIVASSFCNLAEYLFDLLQSRIESDYKLXXXXXXXXXXXXXXXXAEEDILSVSSINNRRMSKCCQTYNNKCKMIQSQLKQAADFSKMLRSDLEISIQLELNLNYSMNDLLSFLSLTKHKMIDLCSSDEQSSINPIDLTLIIPE---ESSSFIKELLDPLITGFSIHPKDDTVRTTLLNSSSSKPRCIKSREYILIINKKSKINWPGEKIKFIYQLDIGNLKQRIESSNIVFLARRPDELTEQLSHLLEFKIPSKHHNIQFKNVIQSCSEGQVEACHYNS------KRTLNALKSKAIEIGQVLHNFFMYDKNDSFSVSELNKIQEET--------VRNSIKNSYSIIFEFYRDLIKLCTGDAFKTVLKNTIVGLLEKWFEFSRKFEPSEKGTVPRWANDGLNFLLQLCQSRVVMTMTKKEWHDFKKSIDNFVEFIVGKSN 3686
            + LP   P +L L +  + ++H C++  L   +     E S+++IKQ + + K+ L+  +  +Q+             +F+     +   K D ++  F        + DL  +L  Y D ++  ++   +   +        + LLEEEW F K   H I+  E      FC++A  L     S +E  + L          +   S ++E   SV  I     S+  +   ++ +    +  +A  F+KMLR DLEI+   E  L+  + DLL  L   ++  + +   +        +L + +P+   E  S I +LL+           DD +    L  +    R   S +        S   W  + +K + Q++  +  + ++  N++ +                  + S H  IQ K   QS  EG +  C   +       + L  LK+ A+E+   + N    D+ D    SE +   +E+         R ++   Y+  FE+++++++L +G+ F+  + +  +    KW  +      S +GT PRWA  G +F LQ  +   +  + + ++   +  ++  +  ++GK +
Sbjct:  607 MDLPSFEPAFLVLCRVLLNVIHECLKLRL---EQRPAGEPSLLSIKQLVRECKEVLKGGLLMKQYY------------QFMLQEVLEDLEKPDCNIDAF--------EEDLHKMLMVYFDYMRSWIQMLQQLPQASH----SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLE--FGLQESCAEFWTSADDSSASDEIRRSVIEI-----SRALKELFHEAR---ERASKALGFAKMLRKDLEIAA--EFRLSAPVRDLLDVLKSKQYVKVQIPGLE--------NLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAYLLLTKHGDRARDSED--------SWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVV-----------------MQSAHLTIQRKAFQQSI-EGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAI--DRVDHMFTSEFDAEVDESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGE-FRQKIGDKYISFARKWMNYVLTKCESGRGTRPRWATQGFDF-LQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPH 1134
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. UniProt/SwissProt
Match: sp|O08648|M3K4_MOUSE (Mitogen-activated protein kinase kinase kinase 4 OS=Mus musculus OX=10090 GN=Map3k4 PE=1 SV=2)

HSP 1 Score: 193.741 bits (491), Expect = 4.030e-48
Identity = 118/304 (38.82%), Postives = 164/304 (53.95%), Query Frame = 3 
Query: 4149 NLMGFVRDS--NSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDLI-----ECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLK----DIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQH-LAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKL 5024
            N++G V D+  + DN     ++K  F+W +   IG+G  G V+   ++DT E+MAMKEI   +P     I     E  +   + H +L++Y GV++    M IF EYC+ G+L +VS L + E  +R +TKQI  AI  LH H IVHRD+K  NIFL     T+    KLGDFG +  L N+   +        GT  YMAPEV            G+    DIWSLGC+V+ M+TGK PW EY+H   I Y +GM   P IP      R++ E + F+  CL+ +P  R  A  LL+  FVK+
Sbjct: 1305 NIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRF-QPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIRLYTKQITVAINVLHEHGIVHRDIKGANIFL-----TSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVIT-----RAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIP-----ERLSPEGKAFLSHCLESDPKIRWTASQLLDHAFVKV 1592

HSP 2 Score: 75.0998 bits (183), Expect = 6.988e-12
Identity = 97/462 (21.00%), Postives = 185/462 (40.04%), Query Frame = 3 
Query: 2352 RKLLEEEWTFVKTYCHNIKQEEEIVASSFCNLAEYLFDLLQSRIESDYKLXXXXXXXXXXXXXXXXAEEDILSVSSINNRRMSKCCQTYNNKCKMIQSQLKQAADFSKMLRSDLEISIQLELNLNYSMNDLLSFLSLTKHKMIDLCSSDEQSSINPIDLTLIIPE---ESSSFIKELLDPLITGFSIHPKDDTVRTTLLNSSSSKPRCIKSREYILIINKKSKINWPGEKIKFIYQLDIGNLKQRIESSNIVFLARRPDELTEQLSHLLEFKIPSKHHNIQFKNVIQSCSEGQVEACHYNS------KRTLNALKSKAIEIGQVLHNFFMYDKNDSFSVSELNKIQEET--------VRNSIKNSYSIIFEFYRDLIKLCTGDAFKTVLKNTIVGLLEKWFEFSRKFEPSEKGTVPRWANDGLNFLLQLCQSRVVMTMTKKEWHDFKKSIDNFVEFIVGKSN 3686
            + LLEEEW F K   H I+  E      FC++A  L     S +ES   L          +     A+E   SV  I     S+  +   ++ +    +  +A  F+KMLR DLEI+   E  L+ S  +LL  L   ++  + +   +        +L + +P+   E    I +LL+           DD      L  +    R   S +            W    +K + Q++  +  + ++  N++ +                  + S H  +Q K   QS  EG +   H  +       + L  LK+ A+E+   + +    D+ D     E +   EE+         R ++   Y+  FE+++++++L +G+ F+  + +  +   +KW  +      S +GT PRWA  G +F LQ  +   +  + + ++   +  ++  +  ++GK +
Sbjct:  714 KNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLESG--LQESCAELWTSADDNGAADELRRSVIEI-----SRALKELFHEAR---ERASKALGFAKMLRKDLEIAA--EFVLSASARELLDALKAKQYVKVQIPGLE--------NLHVFVPDSLAEEKKIILQLLNAATGKDCSKDPDDVFMDAFLLLTKHGDRARDSED--------GWGTWEARAVKIVPQVETVDTLRSMQVDNLLLVV-----------------MESAHLVLQRKAFQQSI-EGLMTVRHEQTSSQPIIAKGLQQLKNDALELCNRISDAI--DRVDHMFTLEFDAEVEESESATLQQYYREAMIQGYNFGFEYHKEVVRLMSGE-FRQKIGDKYISFAQKWMNYVLTKCESGRGTRPRWATQGFDF-LQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPH 1125
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. UniProt/SwissProt
Match: sp|Q9FZ36|M3K2_ARATH (Mitogen-activated protein kinase kinase kinase 2 OS=Arabidopsis thaliana OX=3702 GN=ANP2 PE=2 SV=1)

HSP 1 Score: 164.081 bits (414), Expect = 2.319e-40
Identity = 106/306 (34.64%), Postives = 167/306 (54.58%), Query Frame = 3 
Query: 4155 MGFVRDSNSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVI---------NEPFSQDL-IECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILD----IPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVN--HLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWD-EYQHLAIYYNLGMKKL-PFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFV 5018
            M F +  +  N S+  IK  P +W K  LIG+G  GTV+   NLD+ E++A+K+++I          +   Q+L  E  LL  L+H ++++Y G       + I  E+  GGS+S  S+L+     PE  +R +T Q+L  + +LH+H I+HRD+K  NI +      N+   KL DFG +K +     + G K +KGT  +MAPEV +        + G++   DIWS+GC V+ M+TGK PW  +Y+ +A  +++G  K  P IP       ++ +A DF++ CL+  P+ R  A +LL   FV
Sbjct:   46 MVFAKSQSPPNNSTVQIK-PPIRWRKGQLIGRGAFGTVYMGMNLDSGELLAVKQVLITSNCASKEKTQAHIQELEEEVKLLKNLSHPNIVRYLGTVREDETLNILLEFVPGGSIS--SLLEKFGAFPESVVRTYTNQLLLGLEYLHNHAIMHRDIKGANILVD-----NQGCIKLADFGASKQVAELATISGAKSMKGTPYWMAPEVIL--------QTGHSFSADIWSVGCTVIEMVTGKAPWSQQYKEIAAIFHIGTTKSHPPIP-----DNISSDANDFLLKCLQQEPNLRPTASELLKHPFV 330
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. UniProt/SwissProt
Match: sp|O22040|ANP1_ARATH (Mitogen-activated protein kinase kinase kinase ANP1 OS=Arabidopsis thaliana OX=3702 GN=ANP1 PE=1 SV=2)

HSP 1 Score: 160.229 bits (404), Expect = 4.877e-39
Identity = 106/305 (34.75%), Postives = 167/305 (54.75%), Query Frame = 3 
Query: 4161 FVRDSNSDNTSSCYIKKAP-FQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFS---------QDLIE-CDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILD----IPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVN--HLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWD-EYQHLAIYYNLGMKKL-PFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFV 5018
            F++ S S    +  +  AP   W K  LIG+G  GTV+   NLD+ E++A+K+++I   F+         Q+L E   LL  L+H ++++Y G       + I  E+  GGS+S  S+L+     PE  +R +T+Q+L  + +LH+H I+HRD+K  NI + N      C  KL DFG +K +     + G K +KGT  +MAPEV +        + G++   DIWS+GC V+ M+TGK PW  +Y+ +A  + +G  K  P IP       ++ +A+DF++ CL+  P+ R  A +LL   FV
Sbjct:   47 FIKPSFSPPPPANTVDMAPPISWRKGQLIGRGAFGTVYMGMNLDSGELLAVKQVLIAANFASKEKTQAHIQELEEEVKLLKNLSHPNIVRYLGTVREDDTLNILLEFVPGGSIS--SLLEKFGPFPESVVRTYTRQLLLGLEYLHNHAIMHRDIKGANILVDN----KGC-IKLADFGASKQVAELATMTGAKSMKGTPYWMAPEVIL--------QTGHSFSADIWSVGCTVIEMVTGKAPWSQQYKEVAAIFFIGTTKSHPPIPDT-----LSSDAKDFLLKCLQEVPNLRPTASELLKHPFV 331
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. UniProt/SwissProt
Match: sp|P25390|SSK22_YEAST (Serine/threonine-protein kinase SSK22 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=SSK22 PE=1 SV=2)

HSP 1 Score: 163.696 bits (413), Expect = 5.165e-39
Identity = 119/371 (32.08%), Postives = 185/371 (49.87%), Query Frame = 3 
Query: 3987 TVAEQGLEHSRDAPNSNKSTDGSSNEDHKDRKRVTLKQAIVELENQLNEKRRQNNLMGFVRDSNSDNTS-----SCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDLI------ECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILD----IPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVN----------------HLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQH-LAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLL 5003
            T AE G++ +R   ++ ++ D  +  +   R R+   +AI  LE  +    RQ   MG V D+           +  +     +W K+  IG G  G V+   NL+  EI+A+KEI I++  +   I      E  +L  LNH ++++Y+GV++    + IF EYCEGGSL+  S+LD      E+  + +T ++LE + +LH   +VHRD+KP+NI L +  G      K  DFG A+ +V                     L ++ GT MYMAPE   +     K K G +   D+W+LGC+VL M TG+ PW    +  AI Y++   ++P +P  D    MT   R F+  CL  +P  R  A++LL
Sbjct:  956 TEAENGMQQARLNIDTEENIDEEATLEINSRLRL---EAIKTLEKTMKRNPRQ---MGKVLDATDQGNKYLLSLASSLSNVSMRWQKRSFIGGGTFGQVYSAINLENGEILAVKEIKIHDTTTMKKIFPLIKEEMTVLEMLNHPNIVQYYGVEVHRDKVNIFMEYCEGGSLA--SLLDHGRIEDEMVTQVYTFELLEGLAYLHQSGVVHRDIKPENILL-DFNGI----IKYVDFGTARTVVGSRTRTVRNAAVQDFGVETKSLNEMMGTPMYMAPE--TISGSAVKGKLGAD---DVWALGCVVLEMATGRRPWSNLDNEWAIMYHVAAGRIPQLPNRD---EMTAAGRAFLERCLVQDPTMRATAVELL 1305
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. TrEMBL
Match: A0A2K5DZD7 (Mitogen-activated protein kinase kinase kinase 4 OS=Aotus nancymaae OX=37293 GN=MAP3K4 PE=4 SV=1)

HSP 1 Score: 272.322 bits (695), Expect = 7.476e-70
Identity = 261/1067 (24.46%), Postives = 455/1067 (42.64%), Query Frame = 3 
Query: 1923 LSLPPLLPHYLFLVKFPIKLMHCCIRKILGSPDISKISELSVITIKQRIIDFKDALQFTMRARQFLFDYTFGINFQINKFLASNSKDFAPKQDVDLSDFLSSSMKEIDGDLSSLLRHYIDCXXXXXXXXXXXXXXXXFEYGEPRKLLEEEWTFVKTYCHNIKQEEEIVASSFCNLAEYLFDLLQSRIESDYKLXXXXXXXXXXXXXXXXAEEDILSVSSINNRRMSKCCQTYNNKCKMIQSQLKQAADFSKMLRSDLEISIQLELNLNYSMNDLLSFLSLTKHKMIDLCSSDEQSSINPIDLTLIIPEESSSFIKELLDPLITGFSIHPKDDTVRTTLLNSSSSKPRCIKSREYILIINKKSKINWPGEKIKFIYQLDIGNLKQRIESSNIVFLARRPDELTEQLSHLLEFKIPSKHHNIQFKNVIQSCSEGQVEACHYNS------KRTLNALKSKAIEIGQVLHNFFMYDKNDSFSVSELNKIQEET--------VRNSIKNSYSIIFEFYRDLIKLCTGDAFKTVLKNTIVGLLEKWFEFSRKFEPSEKGTVPRWANDGLNFLLQLCQSRVVMTMTKKEWHDFKKSIDNFVEFIVGKSNRH--------HXXXXXXXXXXXXXXXXXRSWLVTPKPDVIRGCENNASNSKKIENWDIKCDNRTLRSAFSEPSRMISSDQNSFPNQLDRHIDMKTPGNFNEISFTRSITVAEQGLEHSRDAPNSNKSTDGSSNEDHKDRKRVTLKQAIVELENQLNEKRRQNNLMGFVRDS--NSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVI----NEPFSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLK----DIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQH-LAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKL 5024
            + LP   P +L L +  + ++H C++  L   +     E S+++IKQ + + K+ L+  +  +Q+             +F+     +   K D ++  F        + DL  +L  Y D ++  ++   +   +        + LLEEEW F K   H I+  E      FC++A  L     S +E   +          +S +      D  S S    R + +  +         + +  +A  F+KMLR DLEI+   E  L+  + DLL  L   ++  + +   +      P  L      E  S I +LL+           DD +  T L  +    R   S +        S   W  + +K + Q++  +  + ++  N++ +  +                 S H  IQ K   QS  EG +  C   +       + L  LK+ A+E+   + N    D+ D    SE +   +E+         R ++   Y+  FE+++++++L +G+ F+  + +  +    KW  +      S +GT PRWA  G +FL Q  +   +  + + ++   +  ++  +  ++GK +          H  +                 L+ P P+  RG  ++   + ++ +   +   R+L S  S P+     D+ ++P               +   FTR        +  S+D  +     +             T+++++   E +   + R+ N++G V D+  + DN     ++K  F+W +   IG+G  G V+   ++DT E+MAMKEI      ++   +   E  +   + H +L++Y GV++    M IF EYC+ G+L +VS L + E  +R ++KQI  AI  LH H IVHRD+K  NIFL     T+    KLGDFG +  L N+   +        GT  YMAPEV            G+    DIWSLGC+V+ M+TGK PW EY+H   I Y +GM   P IP      R++ E +DF+  CL+ +P  R  A  LL+ +FVK+
Sbjct:  603 MDLPSFEPAFLVLCRVLLNVIHECLKLRL---EQRPAGEPSLLSIKQLVRECKEVLKGGLLMKQYY------------QFMLQEVLEDLEKPDCNIDAF--------EEDLHKMLMVYFDYMRSWIQMLQQLPQASH----SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEVGLE----------ESCAEFWTSADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAA--EFRLSAPVRDLLGVLKSKQYVKVQIPGLENLQVFVPNTLA-----EEKSIILQLLNAAAGKDCSKDSDDVLIDTYLLLTKHSDRARDSED--------SWGTWKAQPVKVVPQVETVDTLRNMQVDNLLLVVTQ-----------------SAHLTIQRKAFQQSI-EGLITLCQEQTSSQPVIAKALQQLKNDALELCNRISNAI--DRVDHMFTSEFDAEVDESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGE-FRQKIGDKYISFARKWMNYVLTKCESGRGTRPRWATQGFDFL-QAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGLYLAIHRNSPRPVKVPRCHSDPPNPHLIIPTPEGFRG--SSVPENDRLASIAAELQFRSL-SRHSSPTE--ERDEPAYPRG-------------DSSGFTRRSWELRTLINQSKDTASKLGPIE-------------TIQKSVRLFEEKRYREMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIRLYSKQITIAINVLHDHGIVHRDIKGANIFL-----TSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVIT-----RAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIP-----ERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKV 1549
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. TrEMBL
Match: A0A2K5R486 (Mitogen-activated protein kinase kinase kinase 4 OS=Cebus capucinus imitator OX=1737458 GN=MAP3K4 PE=4 SV=1)

HSP 1 Score: 271.937 bits (694), Expect = 7.606e-70
Identity = 261/1070 (24.39%), Postives = 459/1070 (42.90%), Query Frame = 3 
Query: 1923 LSLPPLLPHYLFLVKFPIKLMHCCIRKILGSPDISKISELSVITIKQRIIDFKDALQFTMRARQFLFDYTFGINFQINKFLASNSKDFAPKQDVDLSDFLSSSMKEIDGDLSSLLRHYIDCXXXXXXXXXXXXXXXXFEYGEPRKLLEEEWTFVKTYCHNIKQEEEIVASSFCNLAEYLFDLLQSRIESDYKLXXXXXXXXXXXXXXXXAEEDILSVSSINNRRMSKCCQTYNNKCKMIQSQLKQAADFSKMLRSDLEISIQLELNLNYSMNDLLSFLSLTKHKMIDLCSSDEQSSINPIDLTLIIPE---ESSSFIKELLDPLITGFSIHPKDDTVRTTLLNSSSSKPRCIKSREYILIINKKSKINWPGEKIKFIYQLDIGNLKQRIESSNIVFLARRPDELTEQLSHLLEFKIPSKHHNIQFKNVIQSCSEGQVEACHYNS------KRTLNALKSKAIEIGQVLHNFFMYDKNDSFSVSELNKIQEET--------VRNSIKNSYSIIFEFYRDLIKLCTGDAFKTVLKNTIVGLLEKWFEFSRKFEPSEKGTVPRWANDGLNFLLQLCQSRVVMTMTKKEWHDFKKSIDNFVEFIVGKSNRH--------HXXXXXXXXXXXXXXXXXRSWLVTPKPDVIRGCENNASNSKKIENWDIKCDNRTLRSAFSEPSRMISSDQNSFPNQLDRHIDMKTPGNFNEISFTRSITVAEQGLEHSRDAPNSNKSTDGSSNEDHKDRKRVTLKQAIVELENQLNEKRRQNNLMGFVRDS--NSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVI----NEPFSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLK----DIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQH-LAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKL 5024
            + LP   P +L L +  + ++H C++  L   +     E S+++IKQ + + K+ L+  +  +Q+             +F+     +   K D ++  F        + DL  +L  Y D ++  ++   +   +        + LLEEEW F K   H I+  E      FC++A  L     S +E   +          +S +      D  S S    R + +  +         + +  +A  F+KMLR DLEI+   E  L+  + DLL  L   ++  + +   +        +L + +P+   E  S I +LL+           DD +  T L  +    R   S +        S   W  + +K + Q++  +  + ++  N++ +  +                 S H  IQ K   QS  EG +  C   +       + L  LK+ A+E+   + N    D+ D    SE +   +E+         R ++   Y+  FE+++++++L +G+ F+  + +  +    KW  +      S +GT PRWA  G +FL Q  +   +  + + ++   +  ++  +  ++GK +          H  +                 L+ P P+  RG  ++   + ++ +   +   R+L S  S P+     D+ ++P               +   FTR        +  S+D  +     +             T+++++   E +   + R+ N++G V D+  + DN     ++K  F+W +   IG+G  G V+   ++DT E+MAMKEI      ++   +   E  +   + H +L++Y GV++    M IF EYC+ G+L +VS L + E  +R ++KQI  AI  LH H IVHRD+K  NIFL     T+    KLGDFG +  L N+   +        GT  YMAPEV            G+    DIWSLGC+V+ M+TGK PW EY+H   I Y +GM   P IP      R++ E +DF+  CL+ +P  R  A  LL+ +FVK+
Sbjct:  603 MDLPSFEPAFLVLCRVLLNVIHECLKLRL---EQRPAGEPSLLSIKQLVRECKEVLKGGLLMKQYY------------QFMLQEVLEDLEKPDCNIDAF--------EEDLHKMLMVYFDYMRSWIQMLQQLPQASH----SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEVGLE----------ESCAEFWTSADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAA--EFRLSAPVRDLLGVLKSKQYVKVQIPGLE--------NLQVFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDTYLLLTKHSDRARDSED--------SWGTWKAQPVKVVPQVETVDTLRNMQVDNLLLVVTQ-----------------SAHLTIQRKAFQQSI-EGLITLCQEQTSSQPVIAKALQQLKNDALELCNRISNAI--DRVDHMFTSEFDAEVDESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGE-FRQKIGDKYINFARKWMNYVLTKCESGRGTRPRWATQGFDFL-QAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGLYLAIHRNSPRPVKVPRCHSDPPNPHLIIPTPEGFRG--SSVPENDRLASIAAELQFRSL-SRHSSPTE--ERDEPAYPRG-------------DSSGFTRRSWELRTLISQSKDTASKLGPIE-------------TIQKSVRLFEEKRYREMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIRLYSKQITIAINVLHDHGIVHRDIKGANIFL-----TSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVIT-----RAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIP-----ERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKV 1549
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. TrEMBL
Match: U3D4H1 (Mitogen-activated protein kinase kinase kinase 4 isoform b OS=Callithrix jacchus OX=9483 GN=MAP3K4 PE=2 SV=1)

HSP 1 Score: 271.166 bits (692), Expect = 1.419e-69
Identity = 262/1068 (24.53%), Postives = 459/1068 (42.98%), Query Frame = 3 
Query: 1923 LSLPPLLPHYLFLVKFPIKLMHCCIRKILGSPDISKISELSVITIKQRIIDFKDALQFTMRARQFLFDYTFGINFQINKFLASNSKDFAPKQDVDLSDFLSSSMKEIDGDLSSLLRHYIDCXXXXXXXXXXXXXXXXFEYGEPRKLLEEEWTFVKTYCHNIKQEEEIVASSFCNLAEYLFDLLQSRIESDYKLXXXXXXXXXXXXXXXXAEEDILSVSSINNRRMSKCCQTYNNKCKMIQSQLKQAADFSKMLRSDLEISIQLELNLNYSMNDLLSFLSLTKHKMIDLCSSDEQSSINPIDLTLIIPE---ESSSFIKELLDPLITGFSIHPKDDTVRTT--LLNSSSSKPRCIKSREYILIINKKSKINWPGEKIKFIYQLDIGNLKQRIESSNIVFLARRPDELTEQLSHLLEFKIPSKHHNIQFKNVIQSCSEGQVEACHYNS------KRTLNALKSKAIEIGQVLHNFFMYDKNDSFSVSELNKIQEET--------VRNSIKNSYSIIFEFYRDLIKLCTGDAFKTVLKNTIVGLLEKWFEFSRKFEPSEKGTVPRWANDGLNFLLQLCQSRVVMTMTKKEWHDFKKSIDNFVEFIVGKSNRH----HXXXXXXXXXXXXXXXXXRSWLVTPKPDVIRGCENNASNSKKIENWDIKCDNRTLRSAFSEPSRMISSDQNSFPNQLDRHIDMKTPGNFNEISFTRSITVAEQGLEHSRDAPNSNKSTDGSSNEDHKDRKRVTLKQAIVELENQLNEKRRQNNLMGFVRDS--NSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVI----NEPFSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLK----DIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQH-LAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKL 5024
            + LP   P +L L +  + ++H C++  L   +     E S+++IKQ + + K+ L+  +  +Q+             +F+     +   K D ++  F        + DL  +L  Y D ++  ++   +   +        + LLEEEW F K   H I+  E      FC++A  L     S +E   +          +S +      D  S S    R + +  +         + +  +A  F+KMLR DLEI+   E  L+  + DLL  L   ++  + +   +        +L + IP+   E  S I +LL+           DD +  T  LL   S   R           ++     W  + +K + Q++  +  + ++  N++ +  +                 S H  IQ K   QS  EG +  C   +       + L  LK+ A+E+   + N    D+ D    SE +   +E+         R ++   Y+  FE+++++++L +G+ F+  + +  +    KW  +      S +GT PRWA  G +FL Q  +   +  + + ++   +  ++  +  ++GK +      H  +                 L+ P P+  RG  ++   + ++ +   +   R+L S  S P+     D+ ++P               +   FTR        +  S+D  +     +             T+++++   E +   + R+ N++G V D+  + DN     ++K  F+W +   IG+G  G V+   ++DT E+MAMKEI      ++   +   E  +   + H +L++Y GV++    M IF EYC+ G+L +VS L + E  +R ++KQI  AI  LH H IVHRD+K  NIFL     T+    KLGDFG +  L N+   +        GT  YMAPEV            G+    DIWSLGC+V+ M+TGK PW EY+H   I Y +GM   P IP      R++ E +DF+  CL+ +P  R  A  LL+ +FVK+
Sbjct:  601 MDLPSFEPAFLVLCRVLLNVIHECLKLRL---EQRPAGEPSLLSIKQLVRECKEVLKGGLLMKQYY------------QFMLQEVLEDLEKPDCNIDAF--------EEDLHKMLMVYFDYMRSWIQMLQQLPQASH----SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEVGLE----------ESCAEFWTSADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAA--EFRLSAPVRDLLCVLKSKQYVKVQIPGLE--------NLQVFIPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDTYLLLTKHSDGAR----------DSEDGWGTWKAQPVKVVPQVETVDTLRNMQVDNLLLVVTQ-----------------SAHLTIQRKAFQQSI-EGLITLCQEQTSSQPVIAKALQQLKNDALELCNRISNAI--DRVDHMFTSEFDAEVDESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGE-FRQKIGDKYISFARKWMNYVLTKCESGRGTRPRWATQGFDFL-QAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTAIHRNSPRPVKVPRCHSDPPNPHLIIPTPEGFRG--SSVPENDRLASVAAELQFRSL-SRHSSPTE--ERDEPAYPRG-------------DSSGFTRRSWELRTLISQSKDTASKLGPIE-------------TIQKSVRLFEEKRYREMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIRLYSKQITIAINVLHDHGIVHRDIKGANIFL-----TSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVIT-----RAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIP-----ERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKV 1543
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. TrEMBL
Match: A0A2K6SYH2 (Mitogen-activated protein kinase kinase kinase 4 OS=Saimiri boliviensis boliviensis OX=39432 GN=MAP3K4 PE=4 SV=1)

HSP 1 Score: 270.396 bits (690), Expect = 1.944e-69
Identity = 264/1072 (24.63%), Postives = 462/1072 (43.10%), Query Frame = 3 
Query: 1923 LSLPPLLPHYLFLVKFPIKLMHCCIRKILGSPDISKISELSVITIKQRIIDFKDALQFTMRARQFLFDYTFGINFQINKFLASNSKDFAPKQDVDLSDFLSSSMKEIDGDLSSLLRHYIDCXXXXXXXXXXXXXXXXFEYGEPRKLLEEEWTFVKTYCHNIKQEEEIVASSFCNLAEYLFDLLQSRIESDYKLXXXXXXXXXXXXXXXXAEEDILSVSSINNRRMSKCCQTYNNKCKMIQSQLKQAADFSKMLRSDLEISIQLELNLNYSMNDLLSFLSLTKHKMIDLCSSDEQSSINPIDLTLIIPE---ESSSFIKELLDPLITGFSIHPKDDTVRTT--LLNSSSSKPRCIKSREYILIINKKSKINWPGEKIKFIYQLDIGNLKQRIESSNIVFLARRPDELTEQLSHLLEFKIPSKHHNIQFKNVIQSCSEGQVEACHYNSK------RTLNALKSKAIEIGQVLHNFFMYDKNDSFSVSELNKIQEET--------VRNSIKNSYSIIFEFYRDLIKLCTGDAFKTVLKNTIVGLLEKWFEFSRKFEPSEKGTVPRWANDGLNFLLQLCQSRVVMTMTKKEWHDFKKSIDNFVEFIVGKSNRH--------HXXXXXXXXXXXXXXXXXRSWLVTPKPDVIRGCENNASNSKKIENWDIKCDNRTLRSAFSEPSRMISSDQNSFPNQLDRHIDMKTPGNFNEISFTRSITVAEQGLEHSRDAPNSNKSTDGSSNEDHKDRKRVTLKQAIVELENQLNEKRRQNNLMGFVRDS--NSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVI----NEPFSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLK----DIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQH-LAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKL 5024
            + LP   P +L L +  + ++H C++  L   +     E S+++IKQ + + K+ L+  +  +Q+             +F+     +   K D ++  F        + DL  +L  Y D ++  ++   +   +        + LLEEEW F K   H I+  E      FC++A  L     S +E   +          +S +      D  S S    R + +  +         + +  +A  F+KMLR DLEI+   E  L+  + DLL  L   ++  + +   +        +L + +P+   E  S I +LL+           DD +  T  LL   S   R           ++ S   W  + +K + Q++  +  + ++  N++ +      +TE           S H  IQ K   QS  EG +  C   +       + L  LK+ A+E+   + N    D+ D    SE +   +E+         R ++   Y+  FE+++++++L +G+ F+  + +  +    KW  +      S +GT PRWA  G +FL Q  +   +  + + ++   +  ++  +  ++GK +          H  +                 L+ P P+  RG  ++   + ++ +   +   R+L S  S P+     D+ ++P               +   FTR        +  S+D  +     +             T+++++   E +   + R+ N++G V D+  + DN     ++K  F+W +   IG+G  G V+   ++DT E+MAMKEI      ++   +   E  +   + H +L++Y GV++    M IF EYC+ G+L +VS L + E  +R ++KQI  AI  LH H IVHRD+K  NIFL     T+    KLGDFG +  L N+   +        GT  YMAPEV            G+    DIWSLGC+V+ M+TGK PW EY+H   I Y +GM   P IP      R++ E +DF+  CL+ +P  R  A  LL+ +FVK+
Sbjct:  516 MDLPSFEPAFLVLCRVLLNVIHECLKLRL---EQRPAGEPSLLSIKQLVRECKEVLKGGLLMKQYY------------QFMLQEVLEDLEKPDCNIDAF--------EEDLHKMLMVYFDYMRSWIQMLQQLPQASH----SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEVGLE----------ESCAEFWTSADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAA--EFRLSAPVRDLLGVLKSKQYVKVQIPGLE--------NLQVFVPDTLAEEKSVILQLLNAAAGKDCSKDSDDVLIDTYLLLTKHSDGAR----------DSEDSWGTWKAQPVKVVPQVETVDTLRNMQVDNLLLV------VTE-----------SAHLTIQRKAFQQSI-EGLITLCQEQTSSQPVVAKALQQLKNDALELCNRISNAI--DRVDHMFTSEFDAEVDESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGE-FRQKIGDKYISFARKWMNYVLTKCESGRGTRPRWATQGFDFL-QAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGLYLAIHRNSPRPVKVPRCHSDPPNPHLIIPTPEGFRG--SSVPENDRLASIAAELQFRSL-SRHSSPTE--ERDEPAYPRG-------------DSSGFTRRSWELRTLISQSKDTASKLGPIE-------------TIQKSVRLFEEKRYREMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIRLYSKQITIAINVLHDHGIVHRDIKGANIFL-----TSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVIT-----RAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIP-----ERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKV 1462
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. TrEMBL
Match: A0A2K6RD71 (Mitogen-activated protein kinase kinase kinase 4 OS=Rhinopithecus roxellana OX=61622 GN=MAP3K4 PE=4 SV=1)

HSP 1 Score: 270.781 bits (691), Expect = 2.080e-69
Identity = 262/1066 (24.58%), Postives = 461/1066 (43.25%), Query Frame = 3 
Query: 1923 LSLPPLLPHYLFLVKFPIKLMHCCIRKILGSPDISKISELSVITIKQRIIDFKDALQFTMRARQFLFDYTFGINFQINKFLASNSKDFAPKQDVDLSDFLSSSMKEIDGDLSSLLRHYIDCXXXXXXXXXXXXXXXXFEYGEPRKLLEEEWTFVKTYCHNIKQEEEIVASSFCNLAEYLFDLLQSRIESDYKLXXXXXXXXXXXXXXXXAEEDILSVSSINNRRMSKCCQTYNNKCKMIQSQLKQAADFSKMLRSDLEISIQLELNLNYSMNDLLSFLSLTKHKMIDLCSSDEQSSINPIDLTLIIPE---ESSSFIKELLDPLITGFSIHPKDDTVRTTLLNSSSSKPRCIKSREYILIINKKSKINWPGEKIKFIYQLDIGNLKQRIESSNIVFLARRPDELTEQLSHLLEFKIPSKHHNIQFKNVIQSCSEGQVEACHYNS------KRTLNALKSKAIEIGQVLHNFFMYDKNDSFSVSELNKIQEET--------VRNSIKNSYSIIFEFYRDLIKLCTGDAFKTVLKNTIVGLLEKWFEFSRKFEPSEKGTVPRWANDGLNFLLQLCQSRVVMTMTKKEWHDFKKSIDNFVEFIVGKSNRH----HXXXXXXXXXXXXXXXXXRSWLVTPKPDVIRGCENNASNSKKIENWDIKCDNRTLRSAFSEPSRMISSDQNSFPNQLDRHIDMKTPGNFNEISFTRSITVAEQGLEHSRDAPNSNKSTDGSSNEDHKDRKRVTLKQAIVELENQLNEKRRQNNLMGFVRDS--NSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVI----NEPFSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLK----DIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQH-LAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKL 5024
            + LP   P +L L +  + ++H C++  L   +     E S+++IKQ + + K+ L+  +  +Q+             +F+     +   K D ++  F        + DL  +L  Y D ++  ++   +   +        + LLEEEW F K   H I+  E      FC++A  L     S +E  + L          +   S ++E   SV  I     S+  +   ++ +    +  +A  F+KMLR DLEI+   E  L+  + DLL  L L ++  + +   +        +L + +P+   E  S I +LL+           DD +    L  +    R   S +        S   W  + +K + Q++  +  + ++  N++ +                  + S H  IQ K   QS  EG +  C   +       + L  LKS A+E+   + N    D+ D    SE +   +E+         R ++   Y+  FE+++++++L +G+ F+  + +  +    KW  +      S +GT PRWA  G +FL Q  +   +  + + ++   +  ++  +  ++GK +      H  +                 L+ P P+  RG  ++   + ++ +   +   R+L S  S P+     D+ ++P               +    TR        +  S+D  +     +              +++++   E +   + R+ N++G V D+  + DN     ++K  F+W +   IG+G  G V+   ++DT E+MAMKEI      ++   +   E  +   + H +L++Y GV++    M IF EYC+ G+L +VS L + E  +R ++KQI  AI  LH H IVHRD+K  NIFL     T+    KLGDFG +  L N+   +        GT  YMAPEV            G+    DIWSLGC+V+ M+TGK PW EY+H   I Y +GM   P IP      R++ E +DF+  CL+ +P  R  A  LL+ +FVK+
Sbjct:  606 MDLPSFEPAFLVLCRVLLNVIHECLKLRL---EQRPAGEPSLLSIKQLVRECKEVLKGGLLMKQYY------------QFMLQEVLEDLEKPDCNIDAF--------EEDLHKMLMVYFDYMRSWIQMLQQLPQASH----SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLE--FGLQESCAEFWTSADDSSASDEIRRSVIEI-----SRALKELFHEAR---ERASKALGFAKMLRKDLEIAA--EFRLSAPVRDLLDVLKLKQYVKVQIPGLE--------NLQVFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAYLLLTKHGDRARDSED--------SWGTWETQPVKVVPQVETVDTLRSMQVDNLLLVV-----------------MQSAHLTIQRKAFQQSI-EGLMTLCQEQTSSQPVIAKALQQLKSDALELCNRISNAI--DRVDHMFTSEFDAEVDESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGE-FRQKIGDKYISFARKWMNYVLTKCESGRGTRPRWATQGFDFL-QAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFRG--SSVPENDRLASIAAELQFRSL-SRHSSPTE--ERDEPAYPRG-------------DSSGSTRRSWELRTLISQSKDTASKLGPIEA-------------IQKSVRLFEEKRYREMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIRLYSKQITVAINVLHEHGIVHRDIKGANIFL-----TSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVIT-----RAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIP-----ERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKV 1548
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Cavefish
Match: map3k4 (mitogen-activated protein kinase kinase kinase 4 [Source:ZFIN;Acc:ZDB-GENE-990603-4])

HSP 1 Score: 223.787 bits (569), Expect = 2.491e-58
Identity = 169/569 (29.70%), Postives = 279/569 (49.03%), Query Frame = 3 
Query: 3363 EETVRNSIKNSYSIIFEFYRDLIKLCTGDAFKTVLKNTIVGLLEKWFEFSRKFEPSEKGTVPRWANDGLNFLLQLCQSRVVMTMTKKEWHDFKKSIDNFVEFIVGKSNRHHXXXXXXXXXXXXXXXXXRSWLVTPKPDVIRGCENNASN-SKKIENWDIKC--DNRTLRSAFSEPSRMISSDQNSFPNQLDRHIDMKTPGNFNEISFTRSITVAEQGLEHSRDAPNS-NKSTDGSSNEDHKDRKRVTLKQAIVELENQLNEKRRQNNLMGFVRDS--NSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVI----NEPFSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLK----DIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQH-LAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKL 5024
            ++  R ++   Y+  FE+++++++L +G+ F+  +    +    KW  +      S +GT PRWA  G +FL Q  +   +  + + ++   +  ++  +  ++GK +                 VT R+   +P+P  +  C ++  N S  I N +     +N  L S  +E  +  S  ++S P + DR           E S+ +S   A   +  S +  N  ++S D ++ +D  +     +++AI   E++     RQ N++G V ++  + DN     ++K  F+W +   IG+G  G V+   N+DT E+MAMKEI      ++   +   E  +   + H +L++Y GV++    M IF EYC+ G+L +VS L + E  +R + KQI  AI  LH H IVHRD+K  NIFL     T+    KLGDFG +  L N+   +        GT  YMAPEV            G+    DIWSLGC+++ M+TGK PW EY+H   I Y +GM   P IP      +++ E +DF+  CL+  P  R  A  LL+  FVK+
Sbjct:  953 QQYYREAMVQGYNFAFEYHKEVVRLMSGE-FRQRIGERYISFARKWMNYVLTKCESGRGTRPRWATQGFDFL-QAIEPVFISALPEDDFLSLQALMNECIGHVIGKPH---------------SPVTPRN---SPRPVKVPRCHSDPPNPSLFIPNAEGTSVHENDRLSSVAAE-LQFRSLSRHSSPTE-DR----------EEPSYPKSDHAA--AVRRSWELRNFISQSKDTAARQDPME----AVQRAIRSFEDKRYAALRQRNVIGQVCNTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCINVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIRLYCKQITTAINVLHEHGIVHRDIKGANIFL-----TSSGLIKLGDFGCSVKLKNNAHTMPGEVNSTLGTAAYMAPEVIT-----RAKGEGHGRAADIWSLGCVLIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIP-----EKLSTEGKDFLSHCLESEPKRRWTASALLDHPFVKV 1468
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Cavefish
Match: map3k19 (mitogen-activated protein kinase kinase kinase 19 [Source:ZFIN;Acc:ZDB-GENE-081104-140])

HSP 1 Score: 140.198 bits (352), Expect = 3.276e-36
Identity = 94/282 (33.33%), Postives = 151/282 (53.55%), Query Frame = 3 
Query: 4224 WIKKGLIGQGHAGTVFKVCNLDTM-EIMAMKEIVIN--------EPFSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQV--SILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCL--VNHLDG----LKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFV 5018
            W K  ++G+G  GTV+  C L +  +++A+K+++++        + +S+   E DLL  L H +++ + G  ++ + + IF EY  GGS+S V      +PE     +T+Q+LE + +LH ++++HRD+K +N+ L           KL DFG A+ L  + H  G    LK + GT  +MAPEV       N++ HG   K D+WS+GC V  M TGKPP      +A  + +G +K    P  D     ++EA+ F+  CL IN  +R  A DLL   F+
Sbjct:   16 WAKGEVLGRGAYGTVY--CGLTSQGQLIAVKQVLLDVSTSETAEKEYSRLEREVDLLKNLEHPNIVGFLGTALTDNVISIFMEYVPGGSISSVLNRFGPLPEKVFALYTRQVLEGVAYLHENRVIHRDLKGNNLML-----MPTGVVKLIDFGCARRLNRLTHSGGNSDLLKSVHGTPYWMAPEVI------NETGHG--KKSDVWSIGCTVFEMATGKPPLAHMGKMAALFYIGARKGLMPPLPDD---FSEEAKSFVKACL-INQKQRPSAADLLRHPFI 278
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Cavefish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:103034596])

HSP 1 Score: 146.747 bits (369), Expect = 8.747e-36
Identity = 98/287 (34.15%), Postives = 153/287 (53.31%), Query Frame = 3 
Query: 4212 APFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDL------IECD--LLCKLNHASLLKYHGV--DISLSHMRIFTEYCEGGSLS-QVSILDIPEINL-RQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVN---HLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKKL-PFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKL 5024
            AP  W +  L+GQG  G V+   ++DT   +A K++  + P S +       +EC+  LL  L+H  +++Y+G   D +   + IF EY  GGS+  Q+        N+ R++T+QILE + +LHS+ IVHRD+K  NI L++  G    + KLGDFG +K L        G++ + GT  +M+PEV   D        GY  K D+WSLGC V+ M+T KPPW EY+ +A  + +  +   P +P     +  +++ RDFI     +    R  A +LL   F ++
Sbjct:  352 APVTWRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVQFD-PASPETSKEVSTLECEIQLLKNLHHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANI-LRDSAG----NVKLGDFGASKRLQTICMSSTGVRSVTGTPYWMSPEVISGD--------GYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPILP-----SHTSEQTRDFIRRIF-VEAKHRPSAEELLRHPFSQI 618
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Cavefish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:103034596])

HSP 1 Score: 146.747 bits (369), Expect = 8.747e-36
Identity = 98/287 (34.15%), Postives = 153/287 (53.31%), Query Frame = 3 
Query: 4212 APFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDL------IECD--LLCKLNHASLLKYHGV--DISLSHMRIFTEYCEGGSLS-QVSILDIPEINL-RQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVN---HLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKKL-PFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKL 5024
            AP  W +  L+GQG  G V+   ++DT   +A K++  + P S +       +EC+  LL  L+H  +++Y+G   D +   + IF EY  GGS+  Q+        N+ R++T+QILE + +LHS+ IVHRD+K  NI L++  G    + KLGDFG +K L        G++ + GT  +M+PEV   D        GY  K D+WSLGC V+ M+T KPPW EY+ +A  + +  +   P +P     +  +++ RDFI     +    R  A +LL   F ++
Sbjct:  352 APVTWRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVQFD-PASPETSKEVSTLECEIQLLKNLHHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANI-LRDSAG----NVKLGDFGASKRLQTICMSSTGVRSVTGTPYWMSPEVISGD--------GYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPILP-----SHTSEQTRDFIRRIF-VEAKHRPSAEELLRHPFSQI 618
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Cavefish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:103034596])

HSP 1 Score: 146.747 bits (369), Expect = 8.747e-36
Identity = 98/287 (34.15%), Postives = 153/287 (53.31%), Query Frame = 3 
Query: 4212 APFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDL------IECD--LLCKLNHASLLKYHGV--DISLSHMRIFTEYCEGGSLS-QVSILDIPEINL-RQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVN---HLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKKL-PFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKL 5024
            AP  W +  L+GQG  G V+   ++DT   +A K++  + P S +       +EC+  LL  L+H  +++Y+G   D +   + IF EY  GGS+  Q+        N+ R++T+QILE + +LHS+ IVHRD+K  NI L++  G    + KLGDFG +K L        G++ + GT  +M+PEV   D        GY  K D+WSLGC V+ M+T KPPW EY+ +A  + +  +   P +P     +  +++ RDFI     +    R  A +LL   F ++
Sbjct:  352 APVTWRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVQFD-PASPETSKEVSTLECEIQLLKNLHHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANI-LRDSAG----NVKLGDFGASKRLQTICMSSTGVRSVTGTPYWMSPEVISGD--------GYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPILP-----SHTSEQTRDFIRRIF-VEAKHRPSAEELLRHPFSQI 618
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Sea Lamprey
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:ZFIN;Acc:ZDB-GENE-120215-96])

HSP 1 Score: 137.117 bits (344), Expect = 2.215e-33
Identity = 102/320 (31.87%), Postives = 158/320 (49.38%), Query Frame = 3 
Query: 4104 IVELENQLNEKRRQNNLMGFVRDSNSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQD------LIECD--LLCKLNHASLLKYHGV--DISLSHMRIFTEYCEGGSLSQV--SILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAK---CLVNHLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFV 5018
            I   E      RR    +G     N+D +      +AP  W +  L+GQG  G V+   + DT   +A+K++  + P S +       +EC+  LL  L H  +++Y G   D     + IF EY  GGS+     +   + E   R++T+QILE +  LH + IVHRD+K  NI L++  G    + KLGDFG +K    + +    ++ + GT  +M+PEV  ++ E      GY  K DIWS+GC V+ M+T KPPW E++ +A  + +  +  P  P +   A  ++ ARD +     +    R  A DLL   FV
Sbjct:  319 IFTPEPDEGRARRLAGGVGGELAENADVSPPSRSPRAPTNWQRGKLLGQGAFGRVYLCYDADTGRELAVKQVQFD-PGSVETSKEVNALECEIQLLKNLQHERIVQYFGCLRDPQQKTLSIFMEYMPGGSIKDQLRAYGALTENVTRKYTRQILEGVSFLHGNMIVHRDIKGANI-LRDSTG----NVKLGDFGASKRLQTICSQGTAMRSVTGTPYWMSPEV--INGE------GYGRKADIWSVGCTVVEMLTEKPPWAEFEAMAAIFKIATQ--PTDPRLPLHA--SEHARDLLRRIF-VEAKLRPSAEDLLRHPFV 619
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Sea Lamprey
Match: slka (STE20-like kinase a [Source:ZFIN;Acc:ZDB-GENE-050411-66])

HSP 1 Score: 126.331 bits (316), Expect = 3.053e-29
Identity = 82/270 (30.37%), Postives = 136/270 (50.37%), Query Frame = 3 
Query: 4224 WIKKGLIGQGHAGTVFKVCNLDTMEIMAMK--EIVINEPFSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSI---LDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFV 5018
            W   G +G G  G V+K  N ++  + A K  E    E     ++E ++L   +H +++         + + IF E+C GG++  + +     + E  +R   KQ+LEA+ +LH+H+I+HRD+K  NI L     T E   KL DFGV+      L       GT  +MAPEV + ++ ++     Y++K DIWSLG  ++ +   +PP  E   + +   +  K  P  P++   ++ + E  DF+  CL  NP+ R  AL LL  +F+
Sbjct:   33 WSVIGELGDGAFGKVYKAQNKESGVLAAAKVIETKSEEELEDYMVEIEILALCDHPNIVGLLNAFYYENKLWIFIEFCPGGAVDAIMLELERGLAEPQIRVVCKQMLEALNYLHTHRIIHRDLKAGNILL-----TFEGDVKLADFGVSAKNTRTLQRRDSFIGTPYWMAPEVVMCETMKDAP---YDYKADIWSLGITLIELAQMEPPNHELNPMRVMLKIA-KNDP--PSLSFPSKWSAEFTDFLKKCLDKNPETRWNALQLLQHSFI 291
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000046.1 (pep scaffold:Pmarinus_7.0:GL478035:171:2549:1 gene:ENSPMAG00000000044.1 transcript:ENSPMAT00000000046.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 114.39 bits (285), Expect = 3.455e-29
Identity = 68/164 (41.46%), Postives = 93/164 (56.71%), Query Frame = 3 
Query: 4353 ECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFL-KNIEGTNECHAKLGDFGVAKCLVN---HLDG-LKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGK 4829
            E  +   +NH++L++Y+GV++    M IF EYC+ G+L +VS L + E  +R +TKQI  AI  LH   IVHRD+K    +L  NI  T+  H KLGDFG +  L N    + G +    GT  YMAPEV            G+    DIWSLGC+++ M TGK
Sbjct:   17 EIKIFEGINHSNLVRYYGVELHREEMYIFMEYCDEGTLEEVSRLGLQEPVIRHYTKQICTAITELHERGIVHRDIKVSPPWLGANIFLTSTGHIKLGDFGCSVKLKNISQTMPGEVNSTLGTAAYMAPEVIT-----RARGEGHGRAADIWSLGCVLIEMATGK 175
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Sea Lamprey
Match: map3k19 (mitogen-activated protein kinase kinase kinase 19 [Source:ZFIN;Acc:ZDB-GENE-081104-140])

HSP 1 Score: 111.694 bits (278), Expect = 4.297e-27
Identity = 80/290 (27.59%), Postives = 141/290 (48.62%), Query Frame = 3 
Query: 4224 WIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFS----------------QDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQV--SILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLD-----GLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKK--LPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFV 5018
            WIK   +G+G  GTVF +   +  +++A+KE+ + +  S                QD  E +LL  L+H ++++Y G ++  +   IF E+  GG++++       + E   R +  Q+   + +LH H ++H DVK  N  +     T     KL DFG A+ +   L      GL  + GT  +MAPEV         +  GY  + D+WSLGC +  M  G+PP+ +   +A   ++G++   +P +P        +KEA++F+  C   +  +R  + +LL+  F+
Sbjct:   15 WIKGNRLGKGAFGTVF-LGLTNQGKLIAVKELELRDAQSANGNQGGQKQSELQKLQD--EVELLTTLHHPNVVEYLGTEMEGNRFSIFMEFVPGGTVAETVRGFGPLGESVCRSYIAQMTRGLAYLHGHGVMHGDVKGSNAVI-----TPAGVVKLIDFGCAQRVALALSCHENGGLHSVHGTAYWMAPEVI--------NGTGYARRADVWSLGCTLHEMAVGRPPFADMAPMAALLHIGIRNGIMPGLPQA-----FSKEAQEFVEQCFIRDKLKRPSSQELLSHPFI 283
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Sea Lamprey
Match: MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6865])

HSP 1 Score: 110.538 bits (275), Expect = 1.578e-24
Identity = 82/267 (30.71%), Postives = 135/267 (50.56%), Query Frame = 3 
Query: 4242 IGQGHAGTVFKVCNLDTMEIMAMKEIVINEP---FSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIP--EINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPP-WDEYQHLAIYYNLGMKKLPFIPA-VDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVK 5021
            +G G  G V K  N+ T E++A+K I+  EP   FS    E  ++ +  H +++ Y+G  +    + I  E+C GGSL  +  +  P  E  +   T++ L+ + +LHS   +HRD+K  NI L     T++   KL DFGV+  +   +   K   GT  +MAPEVA V+      K GYNH+ D+W++G   + +   +PP +D +   A++    M K  F P  +    + +    +FI   L  NP +R  A  +L  ++V+
Sbjct:   20 LGSGTYGDVHKARNVQTGELVAIK-IIKLEPGDDFSVIQQEIVMMKECKHTNIVAYYGSYLRHDKLWICMEHCGGGSLQDIYHVTGPLTERQIAYVTRETLQGLAYLHSEGKMHRDIKGANILL-----TDDGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVE-----RKGGYNHQCDVWAVGITAIELAELQPPMFDLHPMRALFL---MSKSGFQPPKLRDKQKWSPVFHNFIKMALTKNPKKRPTAEKMLTHSYVQ 272
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Yeast
Match: SSK22 (MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway; functionally redundant with Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p; SSK22 has a paralog, SSK2, that arose from the whole genome duplication [Source:SGD;Acc:S000000669])

HSP 1 Score: 163.696 bits (413), Expect = 7.439e-41
Identity = 119/371 (32.08%), Postives = 185/371 (49.87%), Query Frame = 3 
Query: 3987 TVAEQGLEHSRDAPNSNKSTDGSSNEDHKDRKRVTLKQAIVELENQLNEKRRQNNLMGFVRDSNSDNTS-----SCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDLI------ECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILD----IPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVN----------------HLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQH-LAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLL 5003
            T AE G++ +R   ++ ++ D  +  +   R R+   +AI  LE  +    RQ   MG V D+           +  +     +W K+  IG G  G V+   NL+  EI+A+KEI I++  +   I      E  +L  LNH ++++Y+GV++    + IF EYCEGGSL+  S+LD      E+  + +T ++LE + +LH   +VHRD+KP+NI L +  G      K  DFG A+ +V                     L ++ GT MYMAPE   +     K K G +   D+W+LGC+VL M TG+ PW    +  AI Y++   ++P +P  D    MT   R F+  CL  +P  R  A++LL
Sbjct:  956 TEAENGMQQARLNIDTEENIDEEATLEINSRLRL---EAIKTLEKTMKRNPRQ---MGKVLDATDQGNKYLLSLASSLSNVSMRWQKRSFIGGGTFGQVYSAINLENGEILAVKEIKIHDTTTMKKIFPLIKEEMTVLEMLNHPNIVQYYGVEVHRDKVNIFMEYCEGGSLA--SLLDHGRIEDEMVTQVYTFELLEGLAYLHQSGVVHRDIKPENILL-DFNGI----IKYVDFGTARTVVGSRTRTVRNAAVQDFGVETKSLNEMMGTPMYMAPE--TISGSAVKGKLGAD---DVWALGCVVLEMATGRRPWSNLDNEWAIMYHVAAGRIPQLPNRD---EMTAAGRAFLERCLVQDPTMRATAVELL 1305
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Yeast
Match: SSK2 (MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress; a HOG-independent function of Ssk2p mediates the calcium-sensitive phenotype of the ptp2 msg5 double disruptant; SSK2 has a paralog, SSK22, that arose from the whole genome duplication [Source:SGD;Acc:S000005314])

HSP 1 Score: 159.458 bits (402), Expect = 1.756e-39
Identity = 114/344 (33.14%), Postives = 168/344 (48.84%), Query Frame = 3 
Query: 4098 QAIVELENQLNEKRRQNNLMGFVRDSNSDN----TSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDLI------ECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQV----SILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFL---------------------------KNIEGTNECHAKLGDFGVAKCLVNHLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQH-LAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLL 5003
            Q+I+ELE ++  KR  +     + DS+  N    + +  I     +W K+  IG G  G V+   +LD  EI+A+KEI I +  S   I      E  +L  LNH +++ Y+GV++    + IF EYCEGGSL+ +     I D  E+  + +T Q+LE + +LH   IVHRDVKP+NI L                             IE  +  H  +     +K + N+ + L D+ GT MYMAPE   +     K K G +   D+WSLGC+VL MITG+ PW    +  AI Y++     P  P  D    ++     F+  CL  NP +R  A++LL
Sbjct: 1222 QSIMELEERI--KRNPHQTGKVIDDSDKGNKYLVSLASSISNVSMRWQKRNFIGGGTFGRVYSAVDLDNGEILAVKEINIQDSKSMQKIFPLIKEEMSVLEILNHPNIVSYYGVEVHRDKVNIFMEYCEGGSLAALLEHGRIED--EMVTQVYTLQLLEGLAYLHESGIVHRDVKPENILLDFNGVIKYVDFGAAKKIANNGTRLASMNKIENADGEHEDVTHVSDSKAVKNNENALLDMMGTPMYMAPE--SITGSTTKGKLGAD---DVWSLGCVVLEMITGRRPWANLDNEWAIMYHVAAGHTPQFPTKD---EVSSAGMKFLERCLIQNPSKRASAVELL 1553
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Yeast
Match: BCK1 (MAPKKK acting in the protein kinase C signaling pathway; the kinase C signaling pathway controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p; MAPKKK is an acronym for mitogen-activated protein (MAP) kinase kinase kinase [Source:SGD;Acc:S000003631])

HSP 1 Score: 154.451 bits (389), Expect = 6.022e-38
Identity = 95/285 (33.33%), Postives = 158/285 (55.44%), Query Frame = 3 
Query: 4218 FQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDLI----------ECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQV----SILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVN-HLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLG-MKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKL 5024
            F W+K  +IG+G  G V+   N+ T E+MA+K++ + +  SQ+            E   L  L+H ++++Y G +   +   +F EY  GGS+  +       D P I  +  T Q+L+ + +LHS  I+HRD+K DN+ L       +   K+ DFG+++   + + +    ++GTV +MAPE+  VD++Q     GY+ KVDIWSLGC+VL M  GK PW   + +A  + +G  K  P IP  D+   +++  R+F+  C +INP++R  A +LL+  F ++
Sbjct: 1173 FAWMKGEMIGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKDLDHLNIVQYLGFENKNNIYSLFLEYVAGGSVGSLIRMYGRFDEPLI--KHLTTQVLKGLAYLHSKGILHRDMKADNLLLDQ-----DGICKISDFGISRKSKDIYSNSDMTMRGTVFWMAPEM--VDTKQ-----GYSAKVDIWSLGCIVLEMFAGKRPWSNLEVVAAMFKIGKSKSAPPIPE-DTLPLISQIGRNFLDACFEINPEKRPTANELLSHPFSEV 1442
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Yeast
Match: SPS1 (Putative protein serine/threonine kinase; localizes to the nucleus and cytoplasm; required for efficient spore packaging, prospore membrane development and closure and localization of enzymes involved in spore wall synthesis; interacts with and required for Ssp1p phosphorylation and turnover; member of the GCKIII subfamily of STE20 kinases; multiply phosphorylated on S/T residues; interacts with 14-3-3 proteins, Bmh1p and Bmh2p; expressed at the end of meiosis [Source:SGD;Acc:S000002931])

HSP 1 Score: 127.487 bits (319), Expect = 5.760e-31
Identity = 92/269 (34.20%), Postives = 132/269 (49.07%), Query Frame = 3 
Query: 4242 IGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDLIEC-----DLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGS----LSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVK 5021
            IG+G+ G V+K  +  T EI+A+K  V+N   S + IE        L +L    +  Y    +    M I  EYC GGS    L +  +  +PE  +     ++   + +LH  + +HRD+K  NI L N EG      KLGDFGV+  + + L       GT  +MAPEV   + +      GYN K DIWSLG     ++ G PP  +Y  + +  NL  +K P +    S A     A+DF+ GCL   P +R  A +LL+F FVK
Sbjct:   24 IGRGNFGDVYKAVDRVTQEIVAIK--VVNLEHSDEDIELLAQEIFFLAELKSPLITNYIATMLEDVSMWIVMEYCGGGSCSDLLKRSYVNGLPEEKVSFIIHEVTLGLKYLHEQRKIHRDIKAANILL-NEEGM----VKLGDFGVSGHIRSTLKR-DTFVGTPYWMAPEVVCCEVD------GYNEKADIWSLGITTYELLKGLPPLSKYDPMKVMTNLPKRKPPKLQGPFSDA-----AKDFVAGCLVKTPADRPSAYNLLSFEFVK 273
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Yeast
Match: RAD53 (DNA damage response protein kinase; required for cell-cycle arrest, regulation of copper genes in response to DNA damage; phosphorylates nuclear pores to counteract gene gating, preventing aberrant transitions at forks approaching transcribed genes; activates downstream kinase Dun1p; differentially senses mtDNA depletion, mitochondrial ROS; relocalizes to cytosol under hypoxia; human homolog CHEK2 implicated in breast cancer can complement yeast null mutant [Source:SGD;Acc:S000006074])

HSP 1 Score: 123.25 bits (308), Expect = 1.078e-28
Identity = 87/272 (31.99%), Postives = 137/272 (50.37%), Query Frame = 3 
Query: 4239 LIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQ-DLI--ECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSIL--DIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLKDIKGTVMYMAPEV-----AVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKL 5024
            ++GQG   TV K     T +  A+K I   +     D +  E ++L KLNH  +++  G         +  E+  GG L         + E   R+ ++QIL AI ++HS  I HRD+KPDNI    IE  +    K+ DFG+AK   N    +K   GT+ Y+APEV       V  ++ + ++ Y+  VD+WS+GC+V  ++TG  P+       +Y  +G       P  D   R+++EARDFI   L+++P+ R  A   LN  ++K+
Sbjct:  203 VVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNIL---IEQDDPVLVKITDFGLAKVQGNG-SFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKD--FRISEEARDFIDSLLQVDPNNRSTAAKALNHPWIKM 468
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Nematostella
Match: EDO41410 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4G7])

HSP 1 Score: 144.821 bits (364), Expect = 2.614e-38
Identity = 92/278 (33.09%), Postives = 155/278 (55.76%), Query Frame = 3 
Query: 4224 WIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEI---VINEPFSQDLI----ECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSL----SQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCL--VNHLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFV 5018
            W K  L+G G  G V+   +LDT   +A+K+I    +N     ++     E + +    +  +++Y+G++    H+ IF EY  GGS+     Q   L+  E   R++++QILE I++LH+++IVHRD+K  NI L+++ G    + KL DFG +K L  +    G + + GT  +MAPEV  ++ E      GY  K D+WS+GC V+ M+T KPPW +++ +A  + +  +  P  P + S   ++ +A +F+   L++N   R  A +LL F+FV
Sbjct:    4 WRKGKLLGAGAFGQVYMCHDLDTGRELAVKQIETGQLNSSTKNEVKALEGEIEFMKAFRNERIVQYYGIETDDLHIYIFMEYLPGGSIHEHIKQHGALN--ESLTRKYSRQILEGILYLHTNRIVHRDIKGANI-LRDLYG----NVKLADFGASKRLQTIRSKTGFRSVHGTPYWMAPEV--INGE------GYGRKADVWSVGCTVVEMLTTKPPWADFEPMAALFKIATQ--PTEPELPSD--LSVDAVEFVRSTLRMNSKSRPSADELLRFSFV 262
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Nematostella
Match: EDO47821 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RL88])

HSP 1 Score: 128.642 bits (322), Expect = 1.027e-32
Identity = 92/287 (32.06%), Postives = 151/287 (52.61%), Query Frame = 3 
Query: 4218 FQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDLIE---------CDLLCKLNHASLLKYHG--VDISLSHMRIFTEYCEGGSLSQV--SILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAK--CLVN-HLDG---LKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVK 5021
             +W K  ++G+G  GTVF +  ++T E++A+K++ ++ P + D  E           LL  L H ++++Y G  +D S   + IF E+  GGS++Q         E   R++T+QIL+ + +LH++ ++HRD+K  NI L           KL DFG AK  C+V  H+     L+ ++GT  +MAPEV          + G+  K DIWS+GC V  M TG+PPW     L+  + +G      +P +D +   +  A DF+  C+  + D R  A +LL  +F++
Sbjct:    3 IEWQKGNVLGKGAFGTVF-LGLVNTGELIAVKQVELH-PNNVDAAERQYEKLQEEVGLLKSLKHKNIVQYIGTCMDDSQCTINIFMEFVPGGSIAQALKRFGAFVEPVFRRYTRQILDGVSYLHNNNVIHRDIKGGNIML-----MPNGVIKLIDFGCAKKICMVGAHVSKSNILRSMRGTPYWMAPEVI--------RETGHGRKSDIWSIGCTVFEMATGQPPWSNVPPLSAIFAIGNGSP--VPRLDES--FSAAAIDFVTSCMTRDQDTRPSADELLRHDFLQ 270
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Nematostella
Match: EDO42845 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S0A9])

HSP 1 Score: 129.413 bits (324), Expect = 1.594e-32
Identity = 78/263 (29.66%), Postives = 138/263 (52.47%), Query Frame = 3 
Query: 4242 IGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSIL---DIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVK 5021
            +G+G  G+VFK  + ++ +++A+K++ ++    + + E  ++ + +   ++KY+G     + + I  EYC  GS+S +  +    + E  ++   K  L+ + +LH  + +HRD+K  NI L N EG    HAKL DFGVA  L + +     + GT  +MAPEV          + GY+   DIWSLG   + M  GKPP+ +   +   + +  K     P      + +++ +DF+  CL  NP+ER  A +LL  +F++
Sbjct:   30 LGEGSYGSVFKAMHKESGQVVAIKQVPVDTDLQEIIKEISMMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDLMKIRNKTLTEEEIKCVLKYTLKGLEYLHLRRKIHRDIKAGNILL-NSEG----HAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI--------QEVGYDCLADIWSLGITAMEMAEGKPPYADIHPMRAIFMIPTKPP---PTFRDPGQWSEDFKDFVSKCLVKNPEERATATELLQHSFIQ 276
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Nematostella
Match: EDO36150 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SJF2])

HSP 1 Score: 132.109 bits (331), Expect = 5.070e-31
Identity = 88/293 (30.03%), Postives = 146/293 (49.83%), Query Frame = 3 
Query: 4179 SDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVI--NEPFSQDLI------ECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIP--EINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLKDIKG----TVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQ---HLAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLN 5006
            + NT   Y++     W K  L+G G   + +   ++ T  +MA+K++    N    QD +      E  +L +L H  L+K  G      H  IF E+  GGS+S +     P  E  L ++ +QIL+ + +LH +++VHRD+K  NI    ++ T +   ++ DFG A  L   + G  + +G    T+ +MAPEV   +S        Y    D+WS+GC+++ M TGKPPW+ ++   HLA+ + +     P     D    +    RD ++ CL+  P++R  A+DLL 
Sbjct:  564 AANTKHLYLEN--VHWKKGELLGTGAFSSCYGARDVMTGSLMAVKQVSFCRNSKSEQDKVCQTIMDEIAILARLKHPHLIKCLGATRHTGHFNIFLEWMAGGSISMLLSKYGPFEEAILIRYLRQILQGVSYLHENQVVHRDIKGANIL---VDSTGQ-DIRIADFGAAARLATQITGAGEFQGQLLGTIAFMAPEVLRGES--------YGRSCDVWSVGCVLIEMATGKPPWNAHEHSNHLALIFKIACAIGP----PDIPEHLNPGVRDVVLRCLESKPEDRPAAVDLLQ 838
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Nematostella
Match: EDO37069 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SGU2])

HSP 1 Score: 115.931 bits (289), Expect = 1.831e-28
Identity = 86/271 (31.73%), Postives = 132/271 (48.71%), Query Frame = 3 
Query: 4242 IGQGHAGTVFKVCNLDT-MEIMAMKEIVINEPFSQDLI----ECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLS------QVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLKDIKGTVMYMAPEVAVVDSEQNKSKH-GYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFV 5018
            +G G  GTVF V +L    E   +KEI + E    + +    E  LL KLNH +++K+    +   +  I TEYCEGG L       + S     E  +  W  QI+ A+ H+H  +I+HRD+K  NIFLKN         KLGDFG+++ L+   D      GT  YM+PEV          KH GYNHK DIWSLG ++  +   +  +     + + Y +   +LP +     + + + + + F    +  +P  R  A ++L  +F+
Sbjct:   12 LGSGSFGTVFLVEDLKANGERKVLKEIYVGELQPDETVDAMREAKLLSKLNHPNIVKFMDSFMDREYFCIVTEYCEGGDLDDKISAWRKSGKKFDESLILAWFIQIVLAVQHMHEMRILHRDLKTRNIFLKN------NIVKLGDFGISRILMGTSDMATTFTGTPYYMSPEVL---------KHEGYNHKSDIWSLGVVLYELCNLQHAFQGQSLMGVMYKIVEGELPAL-----SDKYSSQLQAFYSRLMDKDPKLRPSANEILKHHFI 262
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Medaka
Match: map3k4 (mitogen-activated protein kinase kinase kinase 4 [Source:NCBI gene;Acc:101174856])

HSP 1 Score: 228.794 bits (582), Expect = 6.448e-60
Identity = 211/851 (24.79%), Postives = 359/851 (42.19%), Query Frame = 3 
Query: 2655 QAADFSKMLRSDLEISIQLELNLNYSMNDLLSFLSLTKHKMIDLCSSDEQSSINPIDLTLIIPEESSSFIKELLDPLITGFSIHPKDDTVRTTLLNSSSSKPRCIKSREYILIINKKSK---------INWPGEKIKFIYQLDIGNLKQRIESSNIVFLARRPDELTEQLSHLLEFKIPSKHHNIQFKNVIQSCSEGQVEACHYNSKRTLNALKSKA----IEIGQVLHN--FFMYDKNDSFSVSELNKIQEETVRNSIKNSYSIIFEFYRDLIKLCTGDAFKTVLKNTIVGLLEKWFEFSRKFEPSEKGTVPRWANDGLNFLLQLCQSRVVMTMTKKEWHDFKKSIDNFVEFIVGKSNRHHXX---XXXXXXXXXXXXXXXRSWLVTPKPDVIRGCENNASNSKKIENWDIKCDNRTLRSAFSEPSRMISSDQNSFPNQLDRHIDMKTPGN---------FNEISFTRSITVAEQGL-EHSRDAPNSNKSTDGSSNEDHKDRKRVTLKQAIVELE----------------NQLNEKR----RQNNLMGFV--RDSNSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDLI-----ECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLK----DIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQH-LAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKLR 5027
            +A  F+KMLR DLE++   + ++   +  LL  L    +  + +   +E     P  L      +    I +LL+                    N  S +   I   +  L+++K              W GE +K + Q++  +  + I+  N++ +  +   L  Q           K      ++V+  C E         S   L  LK+KA    I+I   +    +    + ++      +    +  R ++   Y+  FE+++++++L +G+ F+  +    +    KW  +      S +GT PRWA  G +FL Q  +   +  + + ++ + +  ++  +  ++GK +   +        S          R +   P P+          N +   +  + CD R         ++++ S     P     H + K PGN          +E     S+    + L  HS    +  + +    + ++  R+   L+  I +L+                ++  EKR    +Q N++G V     + DN     ++K  F+W +   IG+G  G V+   N+DT E+MAMKEI   +P     I     E  +   + H +L++Y GV++    M IF EYC+ G+L +VS L + E  +R ++KQI  AI  LH H IVHRD+K  NIFL     T+    KLGDFG +  L N+   +        GT  YMAPEV            G+    DIWSLGC+++ M+TGK PW EY+H   I Y +GM   P IP      +++ E +DF+  CL+  P  R  A  LL+  FVK+R
Sbjct:  678 KALGFAKMLRKDLEVAA--DFSITSGVTCLLEALKKRNYVKVQIPGLEELQVFVPCGLL-----DQRPLILQLLN----------------AAAGNDCSKEHDEITEDDAYLLMSKHGAGDFSSDSEWAQWNGEVLKLVPQMETVDTLRAIKVENMLLVVMQSAHLVAQ----------RKAFQQSMEDVLTLCREQTSSQPLIAS--ALEDLKNKALQLCIKISMAIDRVEYMFTTEFEAEVEESESATLHQYYREAMIQGYNFAFEYHKEVVRLMSGE-FRQRIGERYIAFARKWMTYVLTKCESGRGTKPRWATQGFDFL-QAIEPAFISALPEDDFLNLQALMNECIGHVIGKPHSPVTALYNAPRNSPRPVKVPAPVRCYSDPPNPNSF------IPNPESFSSRSLPCDLR---------NQLLPSGPRPVPQGPGEHGNAKPPGNSPSDVRISSLHENDRLSSVAAEFRSLSRHSSPTEDREEPSYPKIDPNNASRRSWELRNYIAQLKGIAAQQNPMESVRCSIHKFEEKRYAMMKQRNIIGQVCHTPKSFDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCINVDTGELMAMKEIRF-QPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSKLGLQEHVIRLYSKQITTAINVLHEHGIVHRDIKGANIFL-----TSSGLIKLGDFGCSVKLRNNTHTMPGEVNSTLGTAAYMAPEVIT-----RAKGEGHGRAADIWSLGCVLIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIP-----EKLSTEGKDFLCHCLESEPKRRWTASMLLDHPFVKVR 1460
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Medaka
Match: map3k4 (mitogen-activated protein kinase kinase kinase 4 [Source:NCBI gene;Acc:101174856])

HSP 1 Score: 226.483 bits (576), Expect = 3.080e-59
Identity = 210/850 (24.71%), Postives = 358/850 (42.12%), Query Frame = 3 
Query: 2655 QAADFSKMLRSDLEISIQLELNLNYSMNDLLSFLSLTKHKMIDLCSSDEQSSINPIDLTLIIPEESSSFIKELLDPLITGFSIHPKDDTVRTTLLNSSSSKPRCIKSREYILIINKKSK---------INWPGEKIKFIYQLDIGNLKQRIESSNIVFLARRPDELTEQLSHLLEFKIPSKHHNIQFKNVIQSCSEGQVEACHYNSKRTLNALKSKA----IEIGQVLHN--FFMYDKNDSFSVSELNKIQEETVRNSIKNSYSIIFEFYRDLIKLCTGDAFKTVLKNTIVGLLEKWFEFSRKFEPSEKGTVPRWANDGLNFLLQLCQSRVVMTMTKKEWHDFKKSIDNFVEFIVGKSNRHHXX---XXXXXXXXXXXXXXXRSWLVTPKPDVIRGCENNASNSKKIENWDIKCDNRTLRSAFSEPSRMISSDQNSFPNQLDRHIDMKTPGN---------FNEISFTRSITVAEQGL-EHSRDAPNSNKSTDGSSNEDHKDRKRVTLKQAIVELE----------------NQLNEKR----RQNNLMGFV--RDSNSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDLI-----ECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLK----DIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQH-LAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKL 5024
            +A  F+KMLR DLE++   + ++   +  LL  L    +  + +   +E     P  L      +    I +LL+                    N  S +   I   +  L+++K              W GE +K + Q++  +  + I+  N++ +  +   L  Q           K      ++V+  C E         S   L  LK+KA    I+I   +    +    + ++      +    +  R ++   Y+  FE+++++++L +G+ F+  +    +    KW  +      S +GT PRWA  G +FL Q  +   +  + + ++ + +  ++  +  ++GK +   +        S          R +   P P+          N +   +  + CD R         ++++ S     P     H + K PGN          +E     S+    + L  HS    +  + +    + ++  R+   L+  I +L+                ++  EKR    +Q N++G V     + DN     ++K  F+W +   IG+G  G V+   N+DT E+MAMKEI   +P     I     E  +   + H +L++Y GV++    M IF EYC+ G+L +VS L + E  +R ++KQI  AI  LH H IVHRD+K  NIFL     T+    KLGDFG +  L N+   +        GT  YMAPEV            G+    DIWSLGC+++ M+TGK PW EY+H   I Y +GM   P IP      +++ E +DF+  CL+  P  R  A  LL+  FVK+
Sbjct:  678 KALGFAKMLRKDLEVAA--DFSITSGVTCLLEALKKRNYVKVQIPGLEELQVFVPCGLL-----DQRPLILQLLN----------------AAAGNDCSKEHDEITEDDAYLLMSKHGAGDFSSDSEWAQWNGEVLKLVPQMETVDTLRAIKVENMLLVVMQSAHLVAQ----------RKAFQQSMEDVLTLCREQTSSQPLIAS--ALEDLKNKALQLCIKISMAIDRVEYMFTTEFEAEVEESESATLHQYYREAMIQGYNFAFEYHKEVVRLMSGE-FRQRIGERYIAFARKWMTYVLTKCESGRGTKPRWATQGFDFL-QAIEPAFISALPEDDFLNLQALMNECIGHVIGKPHSPVTALYNAPRNSPRPVKVPAPVRCYSDPPNPNSF------IPNPESFSSRSLPCDLR---------NQLLPSGPRPVPQGPGEHGNAKPPGNSPSDVRISSLHENDRLSSVAAEFRSLSRHSSPTEDREEPSYPKIDPNNASRRSWELRNYIAQLKGIAAQQNPMESVRCSIHKFEEKRYAMMKQRNIIGQVCHTPKSFDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCINVDTGELMAMKEIRF-QPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSKLGLQEHVIRLYSKQITTAINVLHEHGIVHRDIKGANIFL-----TSSGLIKLGDFGCSVKLRNNTHTMPGEVNSTLGTAAYMAPEVIT-----RAKGEGHGRAADIWSLGCVLIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIP-----EKLSTEGKDFLCHCLESEPKRRWTASMLLDHPFVKV 1459
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Medaka
Match: map3k4 (mitogen-activated protein kinase kinase kinase 4 [Source:NCBI gene;Acc:101174856])

HSP 1 Score: 196.052 bits (497), Expect = 8.752e-50
Identity = 121/319 (37.93%), Postives = 170/319 (53.29%), Query Frame = 3 
Query: 4119 NQLNEKR----RQNNLMGFV--RDSNSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDLI-----ECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLK----DIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQH-LAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKLR 5027
            ++  EKR    +Q N++G V     + DN     ++K  F+W +   IG+G  G V+   N+DT E+MAMKEI   +P     I     E  +   + H +L++Y GV++    M IF EYC+ G+L +VS L + E  +R ++KQI  AI  LH H IVHRD+K  NIFL     T+    KLGDFG +  L N+   +        GT  YMAPEV            G+    DIWSLGC+++ M+TGK PW EY+H   I Y +GM   P IP      +++ E +DF+  CL+  P  R  A  LL+  FVK+R
Sbjct: 1239 HKFEEKRYAMMKQRNIIGQVCHTPKSFDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCINVDTGELMAMKEIRF-QPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSKLGLQEHVIRLYSKQITTAINVLHEHGIVHRDIKGANIFL-----TSSGLIKLGDFGCSVKLRNNTHTMPGEVNSTLGTAAYMAPEVIT-----RAKGEGHGRAADIWSLGCVLIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIP-----EKLSTEGKDFLCHCLESEPKRRWTASMLLDHPFVKVR 1541

HSP 2 Score: 51.9878 bits (123), Expect = 7.889e-6
Identity = 66/359 (18.38%), Postives = 141/359 (39.28%), Query Frame = 3 
Query: 2655 QAADFSKMLRSDLEISIQLELNLNYSMNDLLSFLSLTKHKMIDLCSSDEQSSINPIDLTLIIPEESSSFIKELLDPLITGFSIHPKDDTVRTTLLNSSSSKPRCIKSREYILIINKKSK---------INWPGEKIKFIYQLDIGNLKQRIESSNIVFLARRPDELTEQLSHLLEFKIPSKHHNIQFKNVIQSCSEGQVEACHYNSKRTLNALKSKA----IEIGQVLHN--FFMYDKNDSFSVSELNKIQEETVRNSIKNSYSIIFEFYRDLIKLCTGDAFKTVLKNTIVGLLEKWFEFSRKFEPSEKGTVPRWANDGLNFLLQLCQSRVVMTMTKKEWHDFKKSIDNFVEFIVGKSN 3686
            +A  F+KMLR DLE++   + ++   +  LL  L    +  + +   +E     P  L      +    I +LL+                    N  S +   I   +  L+++K              W GE +K + Q++  +  + I+  N++ +  +   L  Q           K      ++V+  C E         S   L  LK+KA    I+I   +    +    + ++      +    +  R ++   Y+  FE+++++++L +G+ F+  +    +    KW  +      S +GT PRWA  G +F LQ  +   +  + + ++ + +  ++  +  ++GK +
Sbjct:  800 KALGFAKMLRKDLEVAA--DFSITSGVTCLLEALKKRNYVKVQIPGLEELQVFVPCGLL-----DQRPLILQLLN----------------AAAGNDCSKEHDEITEDDAYLLMSKHGAGDFSSDSEWAQWNGEVLKLVPQMETVDTLRAIKVENMLLVVMQSAHLVAQ----------RKAFQQSMEDVLTLCREQTSSQPLIAS--ALEDLKNKALQLCIKISMAIDRVEYMFTTEFEAEVEESESATLHQYYREAMIQGYNFAFEYHKEVVRLMSGE-FRQRIGERYIAFARKWMTYVLTKCESGRGTKPRWATQGFDF-LQAIEPAFISALPEDDFLNLQALMNECIGHVIGKPH 1121
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Medaka
Match: map3k4 (mitogen-activated protein kinase kinase kinase 4 [Source:NCBI gene;Acc:101174856])

HSP 1 Score: 195.667 bits (496), Expect = 1.033e-49
Identity = 119/318 (37.42%), Postives = 170/318 (53.46%), Query Frame = 3 
Query: 4119 NQLNEKR----RQNNLMGFV--RDSNSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVI----NEPFSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLK----DIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQH-LAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKLR 5027
            ++  EKR    +Q N++G V     + DN     ++K  F+W +   IG+G  G V+   N+DT E+MAMKEI      ++   +   E  +   + H +L++Y GV++    M IF EYC+ G+L +VS L + E  +R ++KQI  AI  LH H IVHRD+K  NIFL     T+    KLGDFG +  L N+   +        GT  YMAPEV            G+    DIWSLGC+++ M+TGK PW EY+H   I Y +GM   P IP      +++ E +DF+  CL+  P  R  A  LL+  FVK+R
Sbjct: 1115 HKFEEKRYAMMKQRNIIGQVCHTPKSFDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCINVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSKLGLQEHVIRLYSKQITTAINVLHEHGIVHRDIKGANIFL-----TSSGLIKLGDFGCSVKLRNNTHTMPGEVNSTLGTAAYMAPEVIT-----RAKGEGHGRAADIWSLGCVLIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIP-----EKLSTEGKDFLCHCLESEPKRRWTASMLLDHPFVKVR 1417

HSP 2 Score: 52.373 bits (124), Expect = 5.828e-6
Identity = 66/352 (18.75%), Postives = 138/352 (39.20%), Query Frame = 3 
Query: 2655 QAADFSKMLRSDLEISIQLELNLNYSMNDLLSFLSLTKHKMIDLCSSDEQSSINPIDLTLIIPEESSSFIKELLDPLITGFSIHPKDDTVR--TTLLNSSSSKPRCIKSREYILIINKKSKINWPGEKIKFIYQLDIGNLKQRIESSNIVFLARRPDELTEQLSHLLEFKIPSKHHNIQFKNVIQSCSEGQVEACHYNSKRTLNALKSKA----IEIGQVLHN--FFMYDKNDSFSVSELNKIQEETVRNSIKNSYSIIFEFYRDLIKLCTGDAFKTVLKNTIVGLLEKWFEFSRKFEPSEKGTVPRWANDGLNFLLQLCQSRVVMTMTKKEWHDFKKSIDNFVEFIVGKSN 3686
            +A  F+KMLR DLE++   + ++   +  LL  L    +  + +   +E     P  L      +    I +LL+           D+       LL S           E+           W GE +K + Q++  +  + I+  N++ +  +   L  Q           K      ++V+  C E         S   L  LK+KA    I+I   +    +    + ++      +    +  R ++   Y+  FE+++++++L +G+ F+  +    +    KW  +      S +GT PRWA  G +F LQ  +   +  + + ++ + +  ++  +  ++GK +
Sbjct:  676 KALGFAKMLRKDLEVAA--DFSITSGVTCLLEALKKRNYVKVQIPGLEELQVFVPCGLL-----DQRPLILQLLNAAAGNDCSKEHDEITEDDAYLLMSKHGAGDFSSDSEWA---------QWNGEVLKLVPQMETVDTLRAIKVENMLLVVMQSAHLVAQ----------RKAFQQSMEDVLTLCREQTSSQPLIAS--ALEDLKNKALQLCIKISMAIDRVEYMFTTEFEAEVEESESATLHQYYREAMIQGYNFAFEYHKEVVRLMSGE-FRQRIGERYIAFARKWMTYVLTKCESGRGTKPRWATQGFDF-LQAIEPAFISALPEDDFLNLQALMNECIGHVIGKPH 997
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Medaka
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:101169290])

HSP 1 Score: 152.14 bits (383), Expect = 1.662e-37
Identity = 101/289 (34.95%), Postives = 156/289 (53.98%), Query Frame = 3 
Query: 4212 APFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDL------IECD--LLCKLNHASLLKYHGV--DISLSHMRIFTEYCEGGSLS-QVSILDIPEINL-RQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAK-----CLVNHLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKKL-PFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKL 5024
            AP  W +  L+GQG  G V+   ++DT   +A K++  + P S +       +EC+  LL  L+H  +++Y+G   D S   + IF EY  GGS+  Q+        N+ R++T+QILE + +LHS+ IVHRD+K  NI L++  G    + KLGDFG +K     C+     G++ + GT  +M+PEV         S  GY  K D+WSLGC V+ M+T KPPW EY+ +A  + +  +   P +P     +  + +ARDFI  C+ +    R  A +LL   F ++
Sbjct:  349 APVTWRRGKLLGQGAFGLVYLCYDVDTGRELAAKQVQFD-PDSPETSKEVSALECEIQLLKNLHHERIVQYYGCLRDHSEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANI-LRDSAG----NVKLGDFGASKRLQTICMSG--TGIRSVTGTPYWMSPEVI--------SGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPLLP-----SHTSDQARDFI-HCIFVEAKHRPSAEELLRHPFSQI 615
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Planmine SMEST
Match: SMESG000054074.1 (SMESG000054074.1)

HSP 1 Score: 2967.95 bits (7693), Expect = 0.000e+0
Identity = 1560/1563 (99.81%), Postives = 1560/1563 (99.81%), Query Frame = 3 
Query:  345 DSNEQLLNNDLPTXXXXXXXXXXXXXXXXXXXXSVASNLTSEINKISKDGATDSDDSDKNERVKYIKLLSKLIDLNMPSKIESNRSNEAYTRRQCFLEKRRYNSDKIESCYPLFCREAFWLELQHRVXXXXXXXXXXXXXXTVSILKELMQFKVEDVDVEDCELPKEKIYAISKPYLTKIKNAHKQLSDLMGRYYYYLSFWSTTATMRNSIIDENPNYIEYYQTITENIDTMQAWQNCCQWLNWKTRQICQLVGIYGNALNNFVIIGHHQNNSSNITVDNTEFNFEEKFSNSTECGDTNCESRNHSADKYRLRSHSLNMAMDYINSTNIVTXXXXXXXXXXXXXXXKFETYADINRRRYGMEKVCSSAINSVSEMLDKYKNLFSITKDENTLPLMHSYAEAVKDGINCPTCINTQNGKQLIYTENLSEASNSSYQTAKPVFDDNQEFPTIQSLRPCNIXXXXXXXXXXXXXXXHIVQEDIPDASDETIMDLLRKKFEMESINYPREPDTFRESKGLFGLRNQVAARLSLPPLLPHYLFLVKFPIKLMHCCIRKILGSPDISKISELSVITIKQRIIDFKDALQFTMRARQFLFDYTFGINFQINKFLASNSKDFAPKQDVDLSDFLSSSMKEIDGDLSSLLRHYIDCXXXXXXXXXXXXXXXXFEYGEPRKLLEEEWTFVKTYCHNIKQEEEIVASSFCNLAEYLFDLLQSRIESDYKLXXXXXXXXXXXXXXXXAEEDILSVSSINNRRMSKCCQTYNNKCKMIQSQLKQAADFSKMLRSDLEISIQLELNLNYSMNDLLSFLSLTKHKMIDLCSSDEQSSINPIDLTLIIPEESSSFIKELLDPLITGFSIHPKDDTVRTTLLNSSSSKPRCIKSREYILIINKKSKINWPGEKIKFIYQLDIGNLKQRIESSNIVFLARRPDELTEQLSHLLEFKIPSKHHNIQFKNVIQSCSEGQVEACHYNSKRTLNALKSKAIEIGQVLHNFFMYDKNDSFSVSELNKIQEETVRNSIKNSYSIIFEFYRDLIKLCTGDAFKTVLKNTIVGLLEKWFEFSRKFEPSEKGTVPRWANDGLNFLLQLCQSRVVMTMTKKEWHDFKKSIDNFVEFIVGKSNRHHXXXXXXXXXXXXXXXXXRSWLVTPKPDVIRGCENNASNSKKIENWDIKCDNRTLRSAFSEPSRMISSDQNSFPNQLDRHIDMKTPGNFNEISFTRSITVAEQGLEHSRDAPNSNKSTDGSSNEDHKDRKRVTLKQAIVELENQLNEKRRQNNLMGFVRDSNSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKLRNH 5033
            DSNEQLLNNDLPTININADLLNLNLNDNFNENASVASNLTSEINKISKDGATDSDDSDKNERVKYIKLLSKLIDLNMPSKIESNRSNEAYTRRQCFLEKRRYNSDK ESCYPLFCREAFWLELQHRVKSRKDDRIKKMKDKTVSILKELMQFKVEDVDVEDCELPKEKIYAISKPYLTKIKNAHKQLSDLMGRYYYYLSFWSTTATMRNSIID NPNYIEYYQTITENIDTMQAWQNCCQWLNWKTRQIC LVGIYGNALNNFVIIGHHQNNSSNITVDNTEFNFEEKFSNSTECGDTNCESRNHSADKYRLRSHSLNMAMDYINSTNIVTSDSSLENLSDSDYESKFETYADINRRRYGMEKVCSSAINSVSEMLDKYKNLFSITKDENTLPLMHSYAEAVKDGINCPTCINTQNGKQLIYTENLSEASNSSYQTAKPVFDDNQEFPTIQSLRPCNISLFSSPSLSSNPSMSHIVQEDIPDASDETIMDLLRKKFEMESINYPREPDTFRESKGLFGLRNQVAARLSLPPLLPHYLFLVKFPIKLMHCCIRKILGSPDISKISELSVITIKQRIIDFKDALQFTMRARQFLFDYTFGINFQINKFLASNSKDFAPKQDVDLSDFLSSSMKEIDGDLSSLLRHYIDCLKELLKKWSKSSTSCKFEYGEPRKLLEEEWTFVKTYCHNIKQEEEIVASSFCNLAEYLFDLLQSRIESDYKLNIDVDNSPNDSPSLSNAEEDILSVSSINNRRMSKCCQTYNNKCKMIQSQLKQAADFSKMLRSDLEISIQLELNLNYSMNDLLSFLSLTKHKMIDLCSSDEQSSINPIDLTLIIPEESSSFIKELLDPLITGFSIHPKDDTVRTTLLNSSSSKPRCIKSREYILIINKKSKINWPGEKIKFIYQLDIGNLKQRIESSNIVFLARRPDELTEQLSHLLEFKIPSKHHNIQFKNVIQSCSEGQVEACHYNSKRTLNALKSKAIEIGQVLHNFFMYDKNDSFSVSELNKIQEETVRNSIKNSYSIIFEFYRDLIKLCTGDAFKTVLKNTIVGLLEKWFEFSRKFEPSEKGTVPRWANDGLNFLLQLCQSRVVMTMTKKEWHDFKKSIDNFVEFIVGKSNRHHSTTSGKSTTNSSKVVTGRSWLVTPKPDVIRGCENNASNSKKIENWDIKCDNRTLRSAFSEPSRMISSDQNSFPNQLDRHIDMKTPGNFNEISFTRSITVAEQGLEHSRDAPNSNKSTDGSSNEDHKDRKRVTLKQAIVELENQLNEKRRQNNLMGFVRDSNSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKLRNH
Sbjct:   96 DSNEQLLNNDLPTININADLLNLNLNDNFNENASVASNLTSEINKISKDGATDSDDSDKNERVKYIKLLSKLIDLNMPSKIESNRSNEAYTRRQCFLEKRRYNSDKTESCYPLFCREAFWLELQHRVKSRKDDRIKKMKDKTVSILKELMQFKVEDVDVEDCELPKEKIYAISKPYLTKIKNAHKQLSDLMGRYYYYLSFWSTTATMRNSIIDANPNYIEYYQTITENIDTMQAWQNCCQWLNWKTRQICLLVGIYGNALNNFVIIGHHQNNSSNITVDNTEFNFEEKFSNSTECGDTNCESRNHSADKYRLRSHSLNMAMDYINSTNIVTSDSSLENLSDSDYESKFETYADINRRRYGMEKVCSSAINSVSEMLDKYKNLFSITKDENTLPLMHSYAEAVKDGINCPTCINTQNGKQLIYTENLSEASNSSYQTAKPVFDDNQEFPTIQSLRPCNISLFSSPSLSSNPSMSHIVQEDIPDASDETIMDLLRKKFEMESINYPREPDTFRESKGLFGLRNQVAARLSLPPLLPHYLFLVKFPIKLMHCCIRKILGSPDISKISELSVITIKQRIIDFKDALQFTMRARQFLFDYTFGINFQINKFLASNSKDFAPKQDVDLSDFLSSSMKEIDGDLSSLLRHYIDCLKELLKKWSKSSTSCKFEYGEPRKLLEEEWTFVKTYCHNIKQEEEIVASSFCNLAEYLFDLLQSRIESDYKLNIDVDNSPNDSPSLSNAEEDILSVSSINNRRMSKCCQTYNNKCKMIQSQLKQAADFSKMLRSDLEISIQLELNLNYSMNDLLSFLSLTKHKMIDLCSSDEQSSINPIDLTLIIPEESSSFIKELLDPLITGFSIHPKDDTVRTTLLNSSSSKPRCIKSREYILIINKKSKINWPGEKIKFIYQLDIGNLKQRIESSNIVFLARRPDELTEQLSHLLEFKIPSKHHNIQFKNVIQSCSEGQVEACHYNSKRTLNALKSKAIEIGQVLHNFFMYDKNDSFSVSELNKIQEETVRNSIKNSYSIIFEFYRDLIKLCTGDAFKTVLKNTIVGLLEKWFEFSRKFEPSEKGTVPRWANDGLNFLLQLCQSRVVMTMTKKEWHDFKKSIDNFVEFIVGKSNRHHSTTSGKSTTNSSKVVTGRSWLVTPKPDVIRGCENNASNSKKIENWDIKCDNRTLRSAFSEPSRMISSDQNSFPNQLDRHIDMKTPGNFNEISFTRSITVAEQGLEHSRDAPNSNKSTDGSSNEDHKDRKRVTLKQAIVELENQLNEKRRQNNLMGFVRDSNSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKLRNH 1658
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Planmine SMEST
Match: SMESG000054074.1 (SMESG000054074.1)

HSP 1 Score: 2911.71 bits (7547), Expect = 0.000e+0
Identity = 1539/1563 (98.46%), Postives = 1539/1563 (98.46%), Query Frame = 3 
Query:  345 DSNEQLLNNDLPTXXXXXXXXXXXXXXXXXXXXSVASNLTSEINKISKDGATDSDDSDKNERVKYIKLLSKLIDLNMPSKIESNRSNEAYTRRQCFLEKRRYNSDKIESCYPLFCREAFWLELQHRVXXXXXXXXXXXXXXTVSILKELMQFKVEDVDVEDCELPKEKIYAISKPYLTKIKNAHKQLSDLMGRYYYYLSFWSTTATMRNSIIDENPNYIEYYQTITENIDTMQAWQNCCQWLNWKTRQICQLVGIYGNALNNFVIIGHHQNNSSNITVDNTEFNFEEKFSNSTECGDTNCESRNHSADKYRLRSHSLNMAMDYINSTNIVTXXXXXXXXXXXXXXXKFETYADINRRRYGMEKVCSSAINSVSEMLDKYKNLFSITKDENTLPLMHSYAEAVKDGINCPTCINTQNGKQLIYTENLSEASNSSYQTAKPVFDDNQEFPTIQSLRPCNIXXXXXXXXXXXXXXXHIVQEDIPDASDETIMDLLRKKFEMESINYPREPDTFRESKGLFGLRNQVAARLSLPPLLPHYLFLVKFPIKLMHCCIRKILGSPDISKISELSVITIKQRIIDFKDALQFTMRARQFLFDYTFGINFQINKFLASNSKDFAPKQDVDLSDFLSSSMKEIDGDLSSLLRHYIDCXXXXXXXXXXXXXXXXFEYGEPRKLLEEEWTFVKTYCHNIKQEEEIVASSFCNLAEYLFDLLQSRIESDYKLXXXXXXXXXXXXXXXXAEEDILSVSSINNRRMSKCCQTYNNKCKMIQSQLKQAADFSKMLRSDLEISIQLELNLNYSMNDLLSFLSLTKHKMIDLCSSDEQSSINPIDLTLIIPEESSSFIKELLDPLITGFSIHPKDDTVRTTLLNSSSSKPRCIKSREYILIINKKSKINWPGEKIKFIYQLDIGNLKQRIESSNIVFLARRPDELTEQLSHLLEFKIPSKHHNIQFKNVIQSCSEGQVEACHYNSKRTLNALKSKAIEIGQVLHNFFMYDKNDSFSVSELNKIQEETVRNSIKNSYSIIFEFYRDLIKLCTGDAFKTVLKNTIVGLLEKWFEFSRKFEPSEKGTVPRWANDGLNFLLQLCQSRVVMTMTKKEWHDFKKSIDNFVEFIVGKSNRHHXXXXXXXXXXXXXXXXXRSWLVTPKPDVIRGCENNASNSKKIENWDIKCDNRTLRSAFSEPSRMISSDQNSFPNQLDRHIDMKTPGNFNEISFTRSITVAEQGLEHSRDAPNSNKSTDGSSNEDHKDRKRVTLKQAIVELENQLNEKRRQNNLMGFVRDSNSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKLRNH 5033
            DSNEQLLNNDLPTININADLLNLNLNDNFNENASVASNLTSEINKISKDGATDSDDSDKNERVKYIKLLSKLIDLNMPSKIESNRSNEAYTRRQCFLEKRRYNSDK ESCYPLFCREAFWLELQHRVKSRKDDRIKKMKDKTVSILKELMQFKVEDVDVEDCELPKEKIYAISKPYLTKIKNAHKQLSDLMGRYYYYLSFWSTTATMRNSIID NPNYIEYYQTITENIDTMQAWQNCCQWLNWKTRQIC LVGIYGNALNNFVIIGHHQNNSSNITVDNTEFNFEEKFSNSTECGDTNCESRNHSADKYRLRSHSLNMAMDYINSTNIVTSDSSLENLSDSDYESKFETYADINRRRYGMEKVCSSAINSVSEMLDKYKNLFSITKDENTLPLMHSYAEAVKDGINCPTCINTQNGKQLIYTENLSEASNSSYQTAKPVFDDNQEFPTIQSLRPCNISLFSSPSLSSNPSMSHIVQEDIPDASDETIMDLLRKKFEMESINYPREPDTFRESKGLFGLRNQVAARLSLPPLLPHYLFLVKFPIKLMHCCIRKILGSPDISKISELSVITIKQRIIDFKDALQFTMRARQFLFDYTFGINFQINKFLASNSKDFAPKQDVDLSDFLSSSMKEIDGDLSSLLRHYIDCLKELLKKWSKSSTSCKFEYGEPRKLLEEEWTFVKTYCHNIKQEEEIVASSFCNLAEYLFDLLQSRIESDYKLNIDVDNSPNDSPSLSNAEEDILSVSSINNRRMSKCCQTYNNKCKMIQSQLKQAADFSKMLRSDLEISIQLELNLNYSMNDLLSFLSLTKHKMIDLCSSDEQSSINPIDLTLIIPEESSSFIKELLDPLITGFSIHPKDDTVRTTLLNSSSSKPRCIKSREYILIINKKSKINWPGEKIKFIYQLDIGNLKQRIESSNIVFLARRPDELTEQLSHLLEFKIPSKHHNIQFKNVIQSCSEGQVEACHYNSKRTLNALKSKAIEIGQVLHNFFMYDKNDSFSVSELNKIQEETVRNSIKNSYSIIFEFYRDLIKLCTGDAFKTVLKNTIVGLLEKWFEFSRKFEPSEKGTVPRWANDGLNFLLQLCQSRVVMTMTKKEWHDFKKSIDNFVEFIVGKSNRHHSTTSGKSTTNSSKVVTGRSWLVTPKPDVIRGCENNASNSKKIENWDIKCDNRTLRSAFSEPSRMISSDQ                     ISFTRSITVAEQGLEHSRDAPNSNKSTDGSSNEDHKDRKRVTLKQAIVELENQLNEKRRQNNLMGFVRDSNSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKLRNH
Sbjct:   96 DSNEQLLNNDLPTININADLLNLNLNDNFNENASVASNLTSEINKISKDGATDSDDSDKNERVKYIKLLSKLIDLNMPSKIESNRSNEAYTRRQCFLEKRRYNSDKTESCYPLFCREAFWLELQHRVKSRKDDRIKKMKDKTVSILKELMQFKVEDVDVEDCELPKEKIYAISKPYLTKIKNAHKQLSDLMGRYYYYLSFWSTTATMRNSIIDANPNYIEYYQTITENIDTMQAWQNCCQWLNWKTRQICLLVGIYGNALNNFVIIGHHQNNSSNITVDNTEFNFEEKFSNSTECGDTNCESRNHSADKYRLRSHSLNMAMDYINSTNIVTSDSSLENLSDSDYESKFETYADINRRRYGMEKVCSSAINSVSEMLDKYKNLFSITKDENTLPLMHSYAEAVKDGINCPTCINTQNGKQLIYTENLSEASNSSYQTAKPVFDDNQEFPTIQSLRPCNISLFSSPSLSSNPSMSHIVQEDIPDASDETIMDLLRKKFEMESINYPREPDTFRESKGLFGLRNQVAARLSLPPLLPHYLFLVKFPIKLMHCCIRKILGSPDISKISELSVITIKQRIIDFKDALQFTMRARQFLFDYTFGINFQINKFLASNSKDFAPKQDVDLSDFLSSSMKEIDGDLSSLLRHYIDCLKELLKKWSKSSTSCKFEYGEPRKLLEEEWTFVKTYCHNIKQEEEIVASSFCNLAEYLFDLLQSRIESDYKLNIDVDNSPNDSPSLSNAEEDILSVSSINNRRMSKCCQTYNNKCKMIQSQLKQAADFSKMLRSDLEISIQLELNLNYSMNDLLSFLSLTKHKMIDLCSSDEQSSINPIDLTLIIPEESSSFIKELLDPLITGFSIHPKDDTVRTTLLNSSSSKPRCIKSREYILIINKKSKINWPGEKIKFIYQLDIGNLKQRIESSNIVFLARRPDELTEQLSHLLEFKIPSKHHNIQFKNVIQSCSEGQVEACHYNSKRTLNALKSKAIEIGQVLHNFFMYDKNDSFSVSELNKIQEETVRNSIKNSYSIIFEFYRDLIKLCTGDAFKTVLKNTIVGLLEKWFEFSRKFEPSEKGTVPRWANDGLNFLLQLCQSRVVMTMTKKEWHDFKKSIDNFVEFIVGKSNRHHSTTSGKSTTNSSKVVTGRSWLVTPKPDVIRGCENNASNSKKIENWDIKCDNRTLRSAFSEPSRMISSDQ---------------------ISFTRSITVAEQGLEHSRDAPNSNKSTDGSSNEDHKDRKRVTLKQAIVELENQLNEKRRQNNLMGFVRDSNSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKLRNH 1637
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Planmine SMEST
Match: SMESG000054074.1 (SMESG000054074.1)

HSP 1 Score: 1788.85 bits (4632), Expect = 0.000e+0
Identity = 900/900 (100.00%), Postives = 900/900 (100.00%), Query Frame = 3 
Query: 2334 FEYGEPRKLLEEEWTFVKTYCHNIKQEEEIVASSFCNLAEYLFDLLQSRIESDYKLXXXXXXXXXXXXXXXXAEEDILSVSSINNRRMSKCCQTYNNKCKMIQSQLKQAADFSKMLRSDLEISIQLELNLNYSMNDLLSFLSLTKHKMIDLCSSDEQSSINPIDLTLIIPEESSSFIKELLDPLITGFSIHPKDDTVRTTLLNSSSSKPRCIKSREYILIINKKSKINWPGEKIKFIYQLDIGNLKQRIESSNIVFLARRPDELTEQLSHLLEFKIPSKHHNIQFKNVIQSCSEGQVEACHYNSKRTLNALKSKAIEIGQVLHNFFMYDKNDSFSVSELNKIQEETVRNSIKNSYSIIFEFYRDLIKLCTGDAFKTVLKNTIVGLLEKWFEFSRKFEPSEKGTVPRWANDGLNFLLQLCQSRVVMTMTKKEWHDFKKSIDNFVEFIVGKSNRHHXXXXXXXXXXXXXXXXXRSWLVTPKPDVIRGCENNASNSKKIENWDIKCDNRTLRSAFSEPSRMISSDQNSFPNQLDRHIDMKTPGNFNEISFTRSITVAEQGLEHSRDAPNSNKSTDGSSNEDHKDRKRVTLKQAIVELENQLNEKRRQNNLMGFVRDSNSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKLRNH 5033
            FEYGEPRKLLEEEWTFVKTYCHNIKQEEEIVASSFCNLAEYLFDLLQSRIESDYKLNIDVDNSPNDSPSLSNAEEDILSVSSINNRRMSKCCQTYNNKCKMIQSQLKQAADFSKMLRSDLEISIQLELNLNYSMNDLLSFLSLTKHKMIDLCSSDEQSSINPIDLTLIIPEESSSFIKELLDPLITGFSIHPKDDTVRTTLLNSSSSKPRCIKSREYILIINKKSKINWPGEKIKFIYQLDIGNLKQRIESSNIVFLARRPDELTEQLSHLLEFKIPSKHHNIQFKNVIQSCSEGQVEACHYNSKRTLNALKSKAIEIGQVLHNFFMYDKNDSFSVSELNKIQEETVRNSIKNSYSIIFEFYRDLIKLCTGDAFKTVLKNTIVGLLEKWFEFSRKFEPSEKGTVPRWANDGLNFLLQLCQSRVVMTMTKKEWHDFKKSIDNFVEFIVGKSNRHHSTTSGKSTTNSSKVVTGRSWLVTPKPDVIRGCENNASNSKKIENWDIKCDNRTLRSAFSEPSRMISSDQNSFPNQLDRHIDMKTPGNFNEISFTRSITVAEQGLEHSRDAPNSNKSTDGSSNEDHKDRKRVTLKQAIVELENQLNEKRRQNNLMGFVRDSNSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKLRNH
Sbjct:   10 FEYGEPRKLLEEEWTFVKTYCHNIKQEEEIVASSFCNLAEYLFDLLQSRIESDYKLNIDVDNSPNDSPSLSNAEEDILSVSSINNRRMSKCCQTYNNKCKMIQSQLKQAADFSKMLRSDLEISIQLELNLNYSMNDLLSFLSLTKHKMIDLCSSDEQSSINPIDLTLIIPEESSSFIKELLDPLITGFSIHPKDDTVRTTLLNSSSSKPRCIKSREYILIINKKSKINWPGEKIKFIYQLDIGNLKQRIESSNIVFLARRPDELTEQLSHLLEFKIPSKHHNIQFKNVIQSCSEGQVEACHYNSKRTLNALKSKAIEIGQVLHNFFMYDKNDSFSVSELNKIQEETVRNSIKNSYSIIFEFYRDLIKLCTGDAFKTVLKNTIVGLLEKWFEFSRKFEPSEKGTVPRWANDGLNFLLQLCQSRVVMTMTKKEWHDFKKSIDNFVEFIVGKSNRHHSTTSGKSTTNSSKVVTGRSWLVTPKPDVIRGCENNASNSKKIENWDIKCDNRTLRSAFSEPSRMISSDQNSFPNQLDRHIDMKTPGNFNEISFTRSITVAEQGLEHSRDAPNSNKSTDGSSNEDHKDRKRVTLKQAIVELENQLNEKRRQNNLMGFVRDSNSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKLRNH 909
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Planmine SMEST
Match: SMESG000054074.1 (SMESG000054074.1)

HSP 1 Score: 1729.53 bits (4478), Expect = 0.000e+0
Identity = 879/900 (97.67%), Postives = 879/900 (97.67%), Query Frame = 3 
Query: 2334 FEYGEPRKLLEEEWTFVKTYCHNIKQEEEIVASSFCNLAEYLFDLLQSRIESDYKLXXXXXXXXXXXXXXXXAEEDILSVSSINNRRMSKCCQTYNNKCKMIQSQLKQAADFSKMLRSDLEISIQLELNLNYSMNDLLSFLSLTKHKMIDLCSSDEQSSINPIDLTLIIPEESSSFIKELLDPLITGFSIHPKDDTVRTTLLNSSSSKPRCIKSREYILIINKKSKINWPGEKIKFIYQLDIGNLKQRIESSNIVFLARRPDELTEQLSHLLEFKIPSKHHNIQFKNVIQSCSEGQVEACHYNSKRTLNALKSKAIEIGQVLHNFFMYDKNDSFSVSELNKIQEETVRNSIKNSYSIIFEFYRDLIKLCTGDAFKTVLKNTIVGLLEKWFEFSRKFEPSEKGTVPRWANDGLNFLLQLCQSRVVMTMTKKEWHDFKKSIDNFVEFIVGKSNRHHXXXXXXXXXXXXXXXXXRSWLVTPKPDVIRGCENNASNSKKIENWDIKCDNRTLRSAFSEPSRMISSDQNSFPNQLDRHIDMKTPGNFNEISFTRSITVAEQGLEHSRDAPNSNKSTDGSSNEDHKDRKRVTLKQAIVELENQLNEKRRQNNLMGFVRDSNSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKLRNH 5033
            FEYGEPRKLLEEEWTFVKTYCHNIKQEEEIVASSFCNLAEYLFDLLQSRIESDYKLNIDVDNSPNDSPSLSNAEEDILSVSSINNRRMSKCCQTYNNKCKMIQSQLKQAADFSKMLRSDLEISIQLELNLNYSMNDLLSFLSLTKHKMIDLCSSDEQSSINPIDLTLIIPEESSSFIKELLDPLITGFSIHPKDDTVRTTLLNSSSSKPRCIKSREYILIINKKSKINWPGEKIKFIYQLDIGNLKQRIESSNIVFLARRPDELTEQLSHLLEFKIPSKHHNIQFKNVIQSCSEGQVEACHYNSKRTLNALKSKAIEIGQVLHNFFMYDKNDSFSVSELNKIQEETVRNSIKNSYSIIFEFYRDLIKLCTGDAFKTVLKNTIVGLLEKWFEFSRKFEPSEKGTVPRWANDGLNFLLQLCQSRVVMTMTKKEWHDFKKSIDNFVEFIVGKSNRHHSTTSGKSTTNSSKVVTGRSWLVTPKPDVIRGCENNASNSKKIENWDIKCDNRTLRSAFSEPSRMISSDQ                     ISFTRSITVAEQGLEHSRDAPNSNKSTDGSSNEDHKDRKRVTLKQAIVELENQLNEKRRQNNLMGFVRDSNSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKLRNH
Sbjct:   30 FEYGEPRKLLEEEWTFVKTYCHNIKQEEEIVASSFCNLAEYLFDLLQSRIESDYKLNIDVDNSPNDSPSLSNAEEDILSVSSINNRRMSKCCQTYNNKCKMIQSQLKQAADFSKMLRSDLEISIQLELNLNYSMNDLLSFLSLTKHKMIDLCSSDEQSSINPIDLTLIIPEESSSFIKELLDPLITGFSIHPKDDTVRTTLLNSSSSKPRCIKSREYILIINKKSKINWPGEKIKFIYQLDIGNLKQRIESSNIVFLARRPDELTEQLSHLLEFKIPSKHHNIQFKNVIQSCSEGQVEACHYNSKRTLNALKSKAIEIGQVLHNFFMYDKNDSFSVSELNKIQEETVRNSIKNSYSIIFEFYRDLIKLCTGDAFKTVLKNTIVGLLEKWFEFSRKFEPSEKGTVPRWANDGLNFLLQLCQSRVVMTMTKKEWHDFKKSIDNFVEFIVGKSNRHHSTTSGKSTTNSSKVVTGRSWLVTPKPDVIRGCENNASNSKKIENWDIKCDNRTLRSAFSEPSRMISSDQ---------------------ISFTRSITVAEQGLEHSRDAPNSNKSTDGSSNEDHKDRKRVTLKQAIVELENQLNEKRRQNNLMGFVRDSNSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIVINEPFSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQVSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNECHAKLGDFGVAKCLVNHLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYNHKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKKLPFIPAVDSTARMTKEARDFIVGCLKINPDERLEALDLLNFNFVKLRNH 908
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Planmine SMEST
Match: SMESG000054074.1 (SMESG000054074.1)

HSP 1 Score: 1184.47 bits (3063), Expect = 0.000e+0
Identity = 644/647 (99.54%), Postives = 644/647 (99.54%), Query Frame = 3 
Query:  345 DSNEQLLNNDLPTXXXXXXXXXXXXXXXXXXXXSVASNLTSEINKISKDGATDSDDSDKNERVKYIKLLSKLIDLNMPSKIESNRSNEAYTRRQCFLEKRRYNSDKIESCYPLFCREAFWLELQHRVXXXXXXXXXXXXXXTVSILKELMQFKVEDVDVEDCELPKEKIYAISKPYLTKIKNAHKQLSDLMGRYYYYLSFWSTTATMRNSIIDENPNYIEYYQTITENIDTMQAWQNCCQWLNWKTRQICQLVGIYGNALNNFVIIGHHQNNSSNITVDNTEFNFEEKFSNSTECGDTNCESRNHSADKYRLRSHSLNMAMDYINSTNIVTXXXXXXXXXXXXXXXKFETYADINRRRYGMEKVCSSAINSVSEMLDKYKNLFSITKDENTLPLMHSYAEAVKDGINCPTCINTQNGKQLIYTENLSEASNSSYQTAKPVFDDNQEFPTIQSLRPCNIXXXXXXXXXXXXXXXHIVQEDIPDASDETIMDLLRKKFEMESINYPREPDTFRESKGLFGLRNQVAARLSLPPLLPHYLFLVKFPIKLMHCCIRKILGSPDISKISELSVITIKQRIIDFKDALQFTMRARQFLFDYTFGINFQINKFLASNSKDFAPKQDVDLSDFLSSSMKEIDGDLSSLLRHYIDC 2285
            DSNEQLLNNDLPTININADLLNLNLNDNFNENASVASNLTSEINKISKDGATDSDDSDKNERVKYIKLLSKLIDLNMPSKIESNRSNEAYTRRQCFLEKRRYNSDK ESCYPLFCREAFWLELQHRVKSRKDDRIKKMKDKTVSILKELMQFKVEDVDVEDCELPKEKIYAISKPYLTKIKNAHKQLSDLMGRYYYYLSFWSTTATMRNSIID NPNYIEYYQTITENIDTMQAWQNCCQWLNWKTRQIC LVGIYGNALNNFVIIGHHQNNSSNITVDNTEFNFEEKFSNSTECGDTNCESRNHSADKYRLRSHSLNMAMDYINSTNIVTSDSSLENLSDSDYESKFETYADINRRRYGMEKVCSSAINSVSEMLDKYKNLFSITKDENTLPLMHSYAEAVKDGINCPTCINTQNGKQLIYTENLSEASNSSYQTAKPVFDDNQEFPTIQSLRPCNISLFSSPSLSSNPSMSHIVQEDIPDASDETIMDLLRKKFEMESINYPREPDTFRESKGLFGLRNQVAARLSLPPLLPHYLFLVKFPIKLMHCCIRKILGSPDISKISELSVITIKQRIIDFKDALQFTMRARQFLFDYTFGINFQINKFLASNSKDFAPKQDVDLSDFLSSSMKEIDGDLSSLLRHYIDC
Sbjct:   96 DSNEQLLNNDLPTININADLLNLNLNDNFNENASVASNLTSEINKISKDGATDSDDSDKNERVKYIKLLSKLIDLNMPSKIESNRSNEAYTRRQCFLEKRRYNSDKTESCYPLFCREAFWLELQHRVKSRKDDRIKKMKDKTVSILKELMQFKVEDVDVEDCELPKEKIYAISKPYLTKIKNAHKQLSDLMGRYYYYLSFWSTTATMRNSIIDANPNYIEYYQTITENIDTMQAWQNCCQWLNWKTRQICLLVGIYGNALNNFVIIGHHQNNSSNITVDNTEFNFEEKFSNSTECGDTNCESRNHSADKYRLRSHSLNMAMDYINSTNIVTSDSSLENLSDSDYESKFETYADINRRRYGMEKVCSSAINSVSEMLDKYKNLFSITKDENTLPLMHSYAEAVKDGINCPTCINTQNGKQLIYTENLSEASNSSYQTAKPVFDDNQEFPTIQSLRPCNISLFSSPSLSSNPSMSHIVQEDIPDASDETIMDLLRKKFEMESINYPREPDTFRESKGLFGLRNQVAARLSLPPLLPHYLFLVKFPIKLMHCCIRKILGSPDISKISELSVITIKQRIIDFKDALQFTMRARQFLFDYTFGINFQINKFLASNSKDFAPKQDVDLSDFLSSSMKEIDGDLSSLLRHYIDC 742
The following BLAST results are available for this feature:
BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
MAP3K41.364e-7124.39mitogen-activated protein kinase kinase kinase 4 [... [more]
MAP3K45.225e-7124.30mitogen-activated protein kinase kinase kinase 4 [... [more]
MAP3K42.618e-7024.70mitogen-activated protein kinase kinase kinase 4 [... [more]
MAP3K49.459e-5136.53mitogen-activated protein kinase kinase kinase 4 [... [more]
MAP3K37.820e-3733.12mitogen-activated protein kinase kinase kinase 3 [... [more]
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BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
mtk-14.937e-3832.33MTK1/MEKK4 homolog [Source:UniProtKB/TrEMBL;Acc:O... [more]
mtk-14.944e-3832.33MTK1/MEKK4 homolog [Source:UniProtKB/TrEMBL;Acc:O... [more]
nsy-19.536e-3334.40Mitogen-activated protein kinase kinase kinase nsy... [more]
nsy-11.139e-3234.40Mitogen-activated protein kinase kinase kinase nsy... [more]
cst-17.030e-3029.81Serine/threonine-protein kinase cst-1 Serine/threo... [more]
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BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Mekk11.206e-4635.78gene:FBgn0024329 transcript:FBtr0083684[more]
Mekk11.455e-4635.78gene:FBgn0024329 transcript:FBtr0331353[more]
hpo1.197e-2930.34gene:FBgn0261456 transcript:FBtr0331920[more]
hpo1.197e-2930.34gene:FBgn0261456 transcript:FBtr0086500[more]
Ask11.697e-2933.45gene:FBgn0014006 transcript:FBtr0300256[more]
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BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
map3k42.778e-6724.41mitogen-activated protein kinase kinase kinase 4 [... [more]
map3k31.647e-3534.27mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k31.710e-3534.27mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k33.106e-3534.03mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k21.325e-3434.38mitogen-activated protein kinase kinase kinase 2 [... [more]
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BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ephb14.245e-6824.33EPH receptor B1 [Source:Xenbase;Acc:XB-GENE-488626... [more]
ephb13.957e-6624.02EPH receptor B1 [Source:Xenbase;Acc:XB-GENE-488626... [more]
ephb17.863e-5925.42EPH receptor B1 [Source:Xenbase;Acc:XB-GENE-488626... [more]
ephb11.168e-5229.69EPH receptor B1 [Source:Xenbase;Acc:XB-GENE-488626... [more]
ephb12.415e-5229.22EPH receptor B1 [Source:Xenbase;Acc:XB-GENE-488626... [more]
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BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Map3k41.543e-6325.22mitogen-activated protein kinase kinase kinase 4 [... [more]
Map3k45.761e-4938.82mitogen-activated protein kinase kinase kinase 4 [... [more]
Map3k191.443e-3733.33mitogen-activated protein kinase kinase kinase 19 ... [more]
Map3k191.349e-3633.33mitogen-activated protein kinase kinase kinase 19 ... [more]
Map3k191.693e-3633.33mitogen-activated protein kinase kinase kinase 19 ... [more]
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BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q9Y6R4|M3K4_HUMAN4.543e-5036.53Mitogen-activated protein kinase kinase kinase 4 O... [more]
sp|O08648|M3K4_MOUSE4.030e-4838.82Mitogen-activated protein kinase kinase kinase 4 O... [more]
sp|Q9FZ36|M3K2_ARATH2.319e-4034.64Mitogen-activated protein kinase kinase kinase 2 O... [more]
sp|O22040|ANP1_ARATH4.877e-3934.75Mitogen-activated protein kinase kinase kinase ANP... [more]
sp|P25390|SSK22_YEAST5.165e-3932.08Serine/threonine-protein kinase SSK22 OS=Saccharom... [more]
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BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A2K5DZD77.476e-7024.46Mitogen-activated protein kinase kinase kinase 4 O... [more]
A0A2K5R4867.606e-7024.39Mitogen-activated protein kinase kinase kinase 4 O... [more]
U3D4H11.419e-6924.53Mitogen-activated protein kinase kinase kinase 4 i... [more]
A0A2K6SYH21.944e-6924.63Mitogen-activated protein kinase kinase kinase 4 O... [more]
A0A2K6RD712.080e-6924.58Mitogen-activated protein kinase kinase kinase 4 O... [more]
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BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
map3k42.491e-5829.70mitogen-activated protein kinase kinase kinase 4 [... [more]
map3k193.276e-3633.33mitogen-activated protein kinase kinase kinase 19 ... [more]
map3k38.747e-3634.15mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k38.747e-3634.15mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k38.747e-3634.15mitogen-activated protein kinase kinase kinase 3 [... [more]
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BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
map3k22.215e-3331.88mitogen-activated protein kinase kinase kinase 2 [... [more]
slka3.053e-2930.37STE20-like kinase a [Source:ZFIN;Acc:ZDB-GENE-0504... [more]
ENSPMAT00000000046.13.455e-2941.46pep scaffold:Pmarinus_7.0:GL478035:171:2549:1 gene... [more]
map3k194.297e-2727.59mitogen-activated protein kinase kinase kinase 19 ... [more]
MAP4K31.578e-2430.71mitogen-activated protein kinase kinase kinase kin... [more]
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BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5
Match NameE-valueIdentityDescription
SSK227.439e-4132.08MAP kinase kinase kinase of HOG1 mitogen-activated... [more]
SSK21.756e-3933.14MAP kinase kinase kinase of HOG1 mitogen-activated... [more]
BCK16.022e-3833.33MAPKKK acting in the protein kinase C signaling pa... [more]
SPS15.760e-3134.20Putative protein serine/threonine kinase; localize... [more]
RAD531.078e-2831.99DNA damage response protein kinase; required for c... [more]
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BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO414102.614e-3833.09Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO478211.027e-3232.06Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO428451.594e-3229.66Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO361505.070e-3130.03Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO370691.831e-2831.73Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
map3k46.448e-6024.79mitogen-activated protein kinase kinase kinase 4 [... [more]
map3k43.080e-5924.71mitogen-activated protein kinase kinase kinase 4 [... [more]
map3k48.752e-5037.93mitogen-activated protein kinase kinase kinase 4 [... [more]
map3k41.033e-4937.42mitogen-activated protein kinase kinase kinase 4 [... [more]
map3k31.662e-3734.95mitogen-activated protein kinase kinase kinase 3 [... [more]
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BLAST of Mitogen-activated protein kinase kinase kinase 4 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000054074.10.000e+099.81SMESG000054074.1[more]
SMESG000054074.10.000e+098.46SMESG000054074.1[more]
SMESG000054074.10.000e+0100.00SMESG000054074.1[more]
SMESG000054074.10.000e+097.67SMESG000054074.1[more]
SMESG000054074.10.000e+099.54SMESG000054074.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30030550 ID=SMED30030550|Name=Mitogen-activated protein kinase kinase kinase 4|organism=Schmidtea mediterranea sexual|type=transcript|length=5221bp
GTGGAATTCTCCAATCAAATCATTGCTATCAAAAGCCAAGCGGATAACAA
ATGTCCAATGTTTGATTTTCTTTTCATTACTTCATTGCGCCAAATTAAAT
TATCCACAACTTGCGGTGGTGAAATCGGGCAAGTAAATAGAACAATTAAA
TTATTTAATCACGCCAAATTTATTTACGATGCAAAAGGTTTGATTGATAC
GCAAACTCAAATTAGAATGAGCTTGATAATAACCAATCCAGATCAAAATG
TTTGTACAGATTCAGCAGCGTCAACACTGTCAGGGTACTGGTGGATCGTG
ATCCCAATAATAATATTAATAATAATAATAATAACCAAAATATTGATAGT
AATGAACAGTTATTAAACAATGATTTACCAACGATAAATATAAATGCCGA
TTTATTAAATTTAAATCTAAATGATAATTTCAATGAAAATGCCTCAGTTG
CTAGTAATTTAACAAGTGAAATTAACAAAATTTCAAAAGACGGAGCGACA
GATTCCGACGATTCTGATAAAAATGAGCGGGTTAAGTACATTAAATTACT
CAGTAAACTTATCGACTTAAATATGCCATCAAAAATCGAGTCCAATCGCA
GCAATGAAGCGTATACAAGGCGGCAATGTTTCCTTGAAAAACGGCGATAT
AATTCCGATAAAATTGAGAGCTGTTATCCGTTATTCTGCAGAGAGGCGTT
CTGGTTGGAGCTCCAACATCGGGTAAAGAGCCGAAAGGATGATCGAATTA
AAAAAATGAAAGATAAAACTGTGTCGATTTTAAAGGAGTTAATGCAGTTT
AAGGTCGAAGATGTTGATGTTGAGGATTGTGAATTGCCAAAAGAAAAAAT
CTATGCAATATCGAAGCCATATTTGACAAAAATCAAAAATGCCCACAAAC
AATTGTCGGATCTGATGGGAAGATATTACTATTATCTCTCGTTCTGGTCG
ACAACAGCTACGATGAGAAACTCGATCATTGATGAAAATCCAAATTACAT
AGAATATTATCAAACAATCACTGAGAATATCGATACAATGCAAGCATGGC
AGAACTGTTGCCAATGGCTAAATTGGAAGACTCGACAAATATGTCAATTA
GTTGGCATTTACGGAAATGCATTAAACAACTTTGTCATCATCGGGCATCA
CCAAAATAACTCCAGCAATATCACTGTTGACAACACTGAATTCAATTTTG
AGGAGAAATTCAGTAATAGCACTGAGTGCGGCGATACGAATTGTGAATCC
AGGAATCATTCCGCTGATAAGTACAGACTGCGAAGCCACTCATTAAACAT
GGCTATGGATTACATAAATTCCACTAATATCGTCACAAGCGACTCAAGTC
TTGAGAATCTTTCTGACAGTGATTATGAATCAAAATTCGAAACATATGCC
GACATTAATCGACGCCGATATGGAATGGAAAAGGTCTGTTCTTCTGCTAT
CAACAGTGTTTCTGAAATGCTAGACAAATACAAAAATCTGTTCTCTATAA
CGAAGGATGAAAATACTTTGCCATTAATGCACAGTTATGCTGAAGCCGTT
AAAGATGGAATAAACTGCCCTACTTGCATTAACACCCAAAACGGAAAACA
ATTAATATATACAGAAAATCTAAGTGAAGCAAGCAATTCCAGTTACCAAA
CGGCAAAACCGGTTTTCGATGATAACCAAGAATTTCCGACAATTCAGTCT
TTGCGCCCTTGTAACATCTCTTTATTCTCATCTCCATCACTGTCTTCCAA
TCCCTCAATGTCACATATTGTCCAAGAAGATATTCCCGATGCTTCCGATG
AAACGATAATGGATTTATTACGAAAGAAATTCGAAATGGAATCGATTAAT
TACCCCCGGGAGCCGGACACCTTTCGAGAATCGAAAGGTCTATTTGGATT
GAGGAACCAAGTCGCCGCCAGATTGTCTTTGCCGCCGTTGCTACCTCACT
ATTTATTTTTGGTGAAATTCCCCATCAAATTAATGCATTGCTGTATTCGG
AAAATATTGGGCTCCCCAGATATATCAAAGATTTCCGAGCTGTCAGTGAT
AACGATCAAACAGAGAATTATCGACTTCAAAGATGCTTTGCAATTCACAA
TGAGAGCCAGACAGTTTCTATTTGACTACACATTCGGTATCAATTTCCAA
ATAAACAAATTTTTGGCATCCAATTCCAAAGACTTCGCTCCCAAGCAAGA
TGTTGACCTTTCTGATTTTTTGAGTTCAAGTATGAAAGAAATAGATGGAG
ATTTGTCTAGTTTACTCAGGCATTATATCGATTGTCTGAAAGAATTGCTC
AAGAAATGGAGCAAATCTTCAACATCGTGTAAATTTGAATATGGAGAACC
TAGGAAATTGCTAGAAGAGGAATGGACTTTTGTCAAGACTTATTGCCACA
ATATTAAGCAAGAAGAAGAAATTGTAGCCAGCTCATTTTGTAATTTAGCC
GAATATTTATTCGACTTGCTCCAGTCTAGAATTGAATCCGATTATAAATT
AAATATCGATGTTGACAATAGTCCCAATGACAGTCCGTCTCTGTCAAATG
CCGAAGAAGATATTCTGTCTGTCTCTAGTATCAATAACCGACGCATGTCA
AAATGTTGTCAAACGTATAACAATAAATGCAAAATGATCCAATCTCAACT
TAAGCAAGCGGCAGATTTCTCCAAAATGCTGCGAAGTGACCTGGAGATTA
GCATCCAATTGGAGTTGAATCTCAACTATTCTATGAACGACTTGCTATCA
TTCCTCAGTCTCACAAAGCACAAAATGATTGATTTGTGCTCATCAGATGA
ACAGTCGTCGATTAATCCAATTGATCTTACATTAATCATCCCAGAAGAAA
GCAGCTCTTTTATAAAGGAGCTTCTTGATCCATTAATTACAGGGTTCTCA
ATTCATCCAAAAGATGACACAGTAAGAACGACATTATTGAATTCGTCCTC
ATCTAAACCTCGTTGCATAAAGTCTCGAGAATATATTCTTATCATAAACA
AAAAATCTAAAATCAATTGGCCAGGAGAAAAAATCAAATTTATCTATCAA
TTAGACATTGGTAACCTAAAGCAGAGAATTGAAAGTTCCAATATTGTGTT
TCTCGCTCGTCGACCTGATGAATTGACGGAACAATTGTCGCATTTGTTGG
AATTCAAAATCCCCTCAAAGCATCACAATATTCAATTCAAAAATGTCATA
CAAAGTTGCTCTGAAGGTCAGGTTGAGGCTTGTCACTATAATTCCAAAAG
AACTTTAAATGCTCTCAAAAGCAAAGCCATCGAAATTGGTCAAGTTTTGC
ATAACTTTTTCATGTACGATAAAAATGACTCGTTTTCGGTGTCGGAATTG
AACAAAATCCAAGAAGAAACCGTTAGAAATTCTATTAAGAATTCTTATTC
GATAATTTTTGAATTTTATCGAGACCTTATCAAACTCTGTACAGGTGATG
CCTTTAAGACCGTTCTAAAGAATACAATTGTCGGATTGTTGGAGAAATGG
TTTGAATTTAGCAGAAAATTCGAGCCGAGTGAAAAAGGCACTGTACCCAG
ATGGGCTAATGATGGACTGAATTTTTTGTTACAGCTATGCCAGAGTCGAG
TCGTAATGACAATGACGAAAAAAGAGTGGCACGATTTTAAAAAGAGTATT
GATAATTTTGTGGAATTCATTGTTGGTAAATCAAACCGCCACCACAGTAC
GACAAGTGGCAAATCCACCACAAACAGCAGCAAGGTTGTCACTGGCCGGT
CTTGGCTAGTCACCCCAAAACCAGACGTGATTCGCGGCTGTGAAAACAAT
GCTTCAAACAGTAAAAAAATTGAAAATTGGGATATAAAATGCGATAACCG
AACTCTACGATCAGCATTTAGTGAACCAAGTCGGATGATCAGTTCAGATC
AAAATTCATTCCCCAATCAACTTGATCGCCATATAGATATGAAAACTCCG
GGAAACTTTAATGAAATTTCATTCACTCGCTCTATCACAGTGGCGGAACA
GGGCCTAGAACATTCACGGGATGCGCCGAATAGTAACAAATCGACAGACG
GAAGCAGTAACGAAGATCACAAAGACAGGAAACGAGTCACTTTAAAACAA
GCGATAGTTGAATTAGAGAATCAGTTAAACGAAAAACGTCGACAAAACAA
TTTAATGGGTTTCGTTCGTGATTCCAATAGTGACAATACCAGCTCCTGCT
ACATTAAGAAAGCTCCGTTTCAATGGATTAAAAAAGGTTTGATTGGACAA
GGCCACGCGGGAACGGTTTTCAAGGTCTGCAATTTGGATACAATGGAAAT
TATGGCTATGAAGGAAATAGTCATAAATGAGCCATTTTCACAGGATTTGA
TTGAATGCGATCTCCTGTGTAAACTTAACCATGCTTCTTTGCTTAAATAT
CATGGAGTCGATATCAGCCTCAGCCATATGCGAATTTTCACCGAATATTG
TGAAGGGGGGTCCTTATCACAGGTGTCAATATTAGATATCCCGGAAATCA
ATTTGAGACAGTGGACAAAACAGATTCTAGAAGCCATCATGCATTTACAC
AGTCATAAAATAGTTCACAGAGATGTCAAACCTGATAATATTTTTCTAAA
AAACATAGAAGGAACAAATGAATGTCATGCTAAATTAGGAGACTTTGGGG
TGGCCAAATGCCTTGTCAACCATCTAGATGGACTTAAAGATATCAAGGGC
ACCGTAATGTACATGGCTCCAGAAGTGGCTGTGGTAGATAGTGAGCAAAA
TAAATCAAAACATGGATATAATCATAAAGTCGACATTTGGTCTTTGGGTT
GCATGGTGCTCTACATGATTACTGGGAAGCCGCCGTGGGACGAGTATCAG
CATTTGGCCATCTACTACAATTTGGGAATGAAAAAGTTGCCATTTATTCC
TGCGGTAGACTCGACAGCCAGAATGACTAAAGAAGCGCGAGATTTCATAG
TTGGTTGCCTGAAAATCAATCCGGATGAACGATTAGAAGCCCTAGATTTA
TTGAATTTCAACTTCGTGAAATTGCGCAATCACTGAGTCGGAGGGAGGGG
TGCGAGGGATGTGCCATCGTGGCTACTCTGTAGGTTTCCCGCACTAGACT
AATCATATTTATTTTTTGTTTTCTTGTAAATTTTTCCCAATGAATTAAAT
GGGATTATGAATATGTCTTTGTACATTTTTATATTTCTATGTAAATAAAT
TTTTTGGCATTTCAAAAAAAA
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protein sequence of SMED30030550-orf-1

>SMED30030550-orf-1 ID=SMED30030550-orf-1|Name=SMED30030550-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=122bp
VEFSNQIIAIKSQADNKCPMFDFLFITSLRQIKLSTTCGGEIGQVNRTIK
LFNHAKFIYDAKGLIDTQTQIRMSLIITNPDQNVCTDSAASTLSGYWWIV
IPIIILIIIIITKILIVMNSY*
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protein sequence of SMED30030550-orf-2

>SMED30030550-orf-2 ID=SMED30030550-orf-2|Name=SMED30030550-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1488bp
MPSKIESNRSNEAYTRRQCFLEKRRYNSDKIESCYPLFCREAFWLELQHR
VKSRKDDRIKKMKDKTVSILKELMQFKVEDVDVEDCELPKEKIYAISKPY
LTKIKNAHKQLSDLMGRYYYYLSFWSTTATMRNSIIDENPNYIEYYQTIT
ENIDTMQAWQNCCQWLNWKTRQICQLVGIYGNALNNFVIIGHHQNNSSNI
TVDNTEFNFEEKFSNSTECGDTNCESRNHSADKYRLRSHSLNMAMDYINS
TNIVTSDSSLENLSDSDYESKFETYADINRRRYGMEKVCSSAINSVSEML
DKYKNLFSITKDENTLPLMHSYAEAVKDGINCPTCINTQNGKQLIYTENL
SEASNSSYQTAKPVFDDNQEFPTIQSLRPCNISLFSSPSLSSNPSMSHIV
QEDIPDASDETIMDLLRKKFEMESINYPREPDTFRESKGLFGLRNQVAAR
LSLPPLLPHYLFLVKFPIKLMHCCIRKILGSPDISKISELSVITIKQRII
DFKDALQFTMRARQFLFDYTFGINFQINKFLASNSKDFAPKQDVDLSDFL
SSSMKEIDGDLSSLLRHYIDCLKELLKKWSKSSTSCKFEYGEPRKLLEEE
WTFVKTYCHNIKQEEEIVASSFCNLAEYLFDLLQSRIESDYKLNIDVDNS
PNDSPSLSNAEEDILSVSSINNRRMSKCCQTYNNKCKMIQSQLKQAADFS
KMLRSDLEISIQLELNLNYSMNDLLSFLSLTKHKMIDLCSSDEQSSINPI
DLTLIIPEESSSFIKELLDPLITGFSIHPKDDTVRTTLLNSSSSKPRCIK
SREYILIINKKSKINWPGEKIKFIYQLDIGNLKQRIESSNIVFLARRPDE
LTEQLSHLLEFKIPSKHHNIQFKNVIQSCSEGQVEACHYNSKRTLNALKS
KAIEIGQVLHNFFMYDKNDSFSVSELNKIQEETVRNSIKNSYSIIFEFYR
DLIKLCTGDAFKTVLKNTIVGLLEKWFEFSRKFEPSEKGTVPRWANDGLN
FLLQLCQSRVVMTMTKKEWHDFKKSIDNFVEFIVGKSNRHHSTTSGKSTT
NSSKVVTGRSWLVTPKPDVIRGCENNASNSKKIENWDIKCDNRTLRSAFS
EPSRMISSDQNSFPNQLDRHIDMKTPGNFNEISFTRSITVAEQGLEHSRD
APNSNKSTDGSSNEDHKDRKRVTLKQAIVELENQLNEKRRQNNLMGFVRD
SNSDNTSSCYIKKAPFQWIKKGLIGQGHAGTVFKVCNLDTMEIMAMKEIV
INEPFSQDLIECDLLCKLNHASLLKYHGVDISLSHMRIFTEYCEGGSLSQ
VSILDIPEINLRQWTKQILEAIMHLHSHKIVHRDVKPDNIFLKNIEGTNE
CHAKLGDFGVAKCLVNHLDGLKDIKGTVMYMAPEVAVVDSEQNKSKHGYN
HKVDIWSLGCMVLYMITGKPPWDEYQHLAIYYNLGMKKLPFIPAVDSTAR
MTKEARDFIVGCLKINPDERLEALDLLNFNFVKLRNH*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0003116parenchymal cell
Vocabulary: molecular function
TermDefinition
GO:0004672protein kinase activity
GO:0005524ATP binding
GO:0016301kinase activity
Vocabulary: INTERPRO
TermDefinition
IPR000719Prot_kinase_dom
IPR008271Ser/Thr_kinase_AS
IPR011009Kinase-like_dom_sf
Vocabulary: biological process
TermDefinition
GO:0006468protein phosphorylation
GO:0016310phosphorylation
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 1259..1282
NoneNo IPR availableGENE3DG3DSA:1.10.510.10coord: 1304..1575
e-value: 1.2E-63
score: 216.9
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 1233..1247
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 1233..1258
NoneNo IPR availablePANTHERPTHR24348:SF44SERINE/THREONINE-PROTEIN KINASE DDB_G0278901-RELATEDcoord: 1234..1571
NoneNo IPR availablePANTHERPTHR24348SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATEDcoord: 1234..1571
IPR000719Protein kinase domainSMARTSM00220serkin_6coord: 1306..1570
e-value: 2.6E-71
score: 252.9
IPR000719Protein kinase domainPFAMPF00069Pkinasecoord: 1308..1569
e-value: 1.1E-53
score: 182.3
IPR000719Protein kinase domainPROSITEPS50011PROTEIN_KINASE_DOMcoord: 1306..1575
score: 41.672
IPR008271Serine/threonine-protein kinase, active sitePROSITEPS00108PROTEIN_KINASE_STcoord: 1418..1430
IPR011009Protein kinase-like domain superfamilySUPERFAMILYSSF56112Protein kinase-like (PK-like)coord: 1305..1571