Iroquois-class homeodomain protein IRX-4

Overview
NameIroquois-class homeodomain protein IRX-4
Smed IDSMED30030504
Length (bp)1469
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Iroquois-class homeodomain protein IRX-4 (SMED30030504) t-SNE clustered cells

Violin plots show distribution of expression levels for Iroquois-class homeodomain protein IRX-4 (SMED30030504) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Iroquois-class homeodomain protein IRX-4 (SMED30030504) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Iroquois-class homeodomain protein IRX-4 (SMED30030504) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30030504

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 8

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
parapharyngeal regionSMED30030504h1SMcG0018696 SmedASXL_009974SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
pharynxSMED30030504h1SMcG0018696 dd_Smed_v4_17352_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30030504h1SMcG0018696 dd_Smed_v4_17352_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30030504h1SMcG0018696 dd_Smed_v4_17352_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30030504h1SMcG0018696 dd_Smed_v4_17352_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30030504h1SMcG0018696 dd_Smed_v6_17352_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
whole organismSMED30030504h1SMcG0018696 Contig53130newmark_estsPMID:27612384
Roberts-Galbraith et al., 2016		whole organism asexual adult colorimetric in situ hybridization evidence
whole organismSMED30030504h1SMcG0018696 Contig53130uc_Smed_v2PMID:27612384
Roberts-Galbraith et al., 2016		whole organism asexual adult colorimetric in situ hybridization evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Human
Match: IRX6 (iroquois homeobox 6 [Source:HGNC Symbol;Acc:HGNC:14675])

HSP 1 Score: 147.902 bits (372), Expect = 8.852e-39
Identity = 95/218 (43.58%), Postives = 119/218 (54.59%), Query Frame = 2 
Query:  224 PLMCSFPSDTNLMQVSSTPSNASMFPMNGL----RSNLNHFNGLINQSINLYAPPGVAGCPTMNPYFLESMDHLQLLTNSQKSPMS----SRVLHVPNHSE-NFMEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDE---------------ADDLEDTDSSDIRS-RLQD 802
            P +C  P D+ L+  S+ P   +   + G      +    + G +  S     PP + G   +NP + E  +     T+S   P +     R L    +     +E++   RRKNATRETTS LKAWLNEH+KNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTW+P  K  +E               AD  E T S + R  RL D
Sbjct:   45 PALCCAPYDSRLLG-SARPELGAALGIYGAPYAAAAAAQSYPGYLPYSPE---PPSLYG--ALNPQY-EFKEAAGSFTSSLAQPGAYYPYERTLGQYQYERYGAVELSGAGRRKNATRETTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPKNKGGEERKAEGGEEDSLGCLTADTKEVTASQEARGLRLSD 255
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Human
Match: IRX4 (iroquois homeobox 4 [Source:HGNC Symbol;Acc:HGNC:6129])

HSP 1 Score: 144.821 bits (364), Expect = 3.558e-37
Identity = 66/83 (79.52%), Postives = 71/83 (85.54%), Query Frame = 2 
Query:  500 ENFMEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDE 748
            + +  M+S  RRKNATRETTS LKAWL EH+KNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTW P  K  DE
Sbjct:  135 DRYGTMDSGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCADE 217
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Human
Match: IRX4 (iroquois homeobox 4 [Source:HGNC Symbol;Acc:HGNC:6129])

HSP 1 Score: 144.821 bits (364), Expect = 3.558e-37
Identity = 66/83 (79.52%), Postives = 71/83 (85.54%), Query Frame = 2 
Query:  500 ENFMEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDE 748
            + +  M+S  RRKNATRETTS LKAWL EH+KNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTW P  K  DE
Sbjct:  135 DRYGTMDSGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCADE 217
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Human
Match: IRX4 (iroquois homeobox 4 [Source:HGNC Symbol;Acc:HGNC:6129])

HSP 1 Score: 144.821 bits (364), Expect = 3.558e-37
Identity = 66/83 (79.52%), Postives = 71/83 (85.54%), Query Frame = 2 
Query:  500 ENFMEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDE 748
            + +  M+S  RRKNATRETTS LKAWL EH+KNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTW P  K  DE
Sbjct:  135 DRYGTMDSGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCADE 217
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Human
Match: IRX4 (iroquois homeobox 4 [Source:HGNC Symbol;Acc:HGNC:6129])

HSP 1 Score: 144.436 bits (363), Expect = 6.264e-37
Identity = 66/81 (81.48%), Postives = 70/81 (86.42%), Query Frame = 2 
Query:  506 FMEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDE 748
            +  M+S  RRKNATRETTS LKAWL EH+KNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTW P  K  DE
Sbjct:  163 YGTMDSGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCADE 243
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Celegans
Match: irx-1 (Putative iroquois-class homeodomain protein irx-1 [Source:UniProtKB/Swiss-Prot;Acc:Q93348])

HSP 1 Score: 124.405 bits (311), Expect = 2.926e-31
Identity = 77/161 (47.83%), Postives = 98/161 (60.87%), Query Frame = 2 
Query:  530 RRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDEADDLEDTDSSDIRSRLQDDPASLTKNYSKELKNEFLSK-------LSAINNLSADISNPK-------INSNVTSKSTKPKIWSIADIT 970
            +++NATRE T+ LK WL+ H+KNPYP+K +K+MLAV T MTLTQVSTWFANARRRLKKENKMTWSP  +  D  DD ED D  D+     + P+S T   S+        K        S  +  S +++ PK        N +  S   KPK+WSIAD+T
Sbjct:  118 KKRNATREATAPLKDWLHSHRKNPYPSKADKVMLAVGTGMTLTQVSTWFANARRRLKKENKMTWSPQNRRGDGCDDDEDDDDDDM-----NRPSSSTSINSERKGESLFGKPHLASPTPSGGSGGSDELTTPKKELVSPIPNDDSESPKRKPKMWSIADVT 273
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Celegans
Match: ceh-60 (C. Elegans Homeobox [Source:UniProtKB/TrEMBL;Acc:Q45EK2])

HSP 1 Score: 58.5362 bits (140), Expect = 3.939e-9
Identity = 24/59 (40.68%), Postives = 39/59 (66.10%), Query Frame = 2 
Query:  530 RRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKE 706
            +R+N  + TT IL+ W ++H++NPYP+  EK  LA    + ++QV+ WF N R R K++
Sbjct:  183 KRRNFDKNTTDILQNWFHDHRQNPYPSDQEKAELAKQCNIKISQVNNWFGNQRIRTKQQ 241
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Celegans
Match: ceh-20 (Homeobox protein ceh-20 [Source:UniProtKB/Swiss-Prot;Acc:P41779])

HSP 1 Score: 52.373 bits (124), Expect = 3.951e-7
Identity = 23/63 (36.51%), Postives = 38/63 (60.32%), Query Frame = 2 
Query:  515 MNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKK 703
            +++  +R+N +++ T +L  +   H  NPYP++  K  LA    +T++QVS WF N R R KK
Sbjct:  186 LDARRKRRNFSKQATEVLNEYFYGHLSNPYPSEEAKEDLARQCNITVSQVSNWFGNKRIRYKK 248
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Celegans
Match: unc-62 (Homeobox protein unc-62 [Source:UniProtKB/Swiss-Prot;Acc:Q9N5D6])

HSP 1 Score: 51.2174 bits (121), Expect = 1.127e-6
Identity = 34/117 (29.06%), Postives = 56/117 (47.86%), Query Frame = 2 
Query:  545 TRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRL-----------KKENKMTWSPNQ---KSEDEADDLEDTDSSDIRSRLQDDPASLTKNYSKELKNEF 853
            ++E  +  +AWL  +  +PYP++ +K  LA  T +T+ QV+ WF NARRR+            +  +M    N+   +SE       D+  SD  +    DP+SL  + +     EF
Sbjct:  363 SKEAITKFRAWLFHNLTHPYPSEEQKKQLAKETGLTILQVNNWFINARRRIVQPMIDQNNRAGRSGQMNVCKNRRRNRSEQSPGPSPDS-GSDSGANYSPDPSSLAASTAMPYPAEF 478
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Celegans
Match: unc-62 (Homeobox protein unc-62 [Source:UniProtKB/Swiss-Prot;Acc:Q9N5D6])

HSP 1 Score: 51.2174 bits (121), Expect = 1.127e-6
Identity = 34/117 (29.06%), Postives = 56/117 (47.86%), Query Frame = 2 
Query:  545 TRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRL-----------KKENKMTWSPNQ---KSEDEADDLEDTDSSDIRSRLQDDPASLTKNYSKELKNEF 853
            ++E  +  +AWL  +  +PYP++ +K  LA  T +T+ QV+ WF NARRR+            +  +M    N+   +SE       D+  SD  +    DP+SL  + +     EF
Sbjct:  363 SKEAITKFRAWLFHNLTHPYPSEEQKKQLAKETGLTILQVNNWFINARRRIVQPMIDQNNRAGRSGQMNVCKNRRRNRSEQSPGPSPDS-GSDSGANYSPDPSSLAASTAMPYPAEF 478
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Fly
Match: mirr (gene:FBgn0014343 transcript:FBtr0075911)

HSP 1 Score: 140.198 bits (352), Expect = 2.086e-35
Identity = 65/76 (85.53%), Postives = 69/76 (90.79%), Query Frame = 2 
Query:  509 MEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQK 736
            M++N   RRKNATRETTS LKAWLNEHKKNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTW P  +
Sbjct:  221 MDLNGA-RRKNATRETTSTLKAWLNEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWEPRNR 295
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Fly
Match: mirr (gene:FBgn0014343 transcript:FBtr0075912)

HSP 1 Score: 140.198 bits (352), Expect = 2.086e-35
Identity = 65/76 (85.53%), Postives = 69/76 (90.79%), Query Frame = 2 
Query:  509 MEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQK 736
            M++N   RRKNATRETTS LKAWLNEHKKNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTW P  +
Sbjct:  221 MDLNGA-RRKNATRETTSTLKAWLNEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWEPRNR 295
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Fly
Match: mirr (gene:FBgn0014343 transcript:FBtr0330077)

HSP 1 Score: 140.198 bits (352), Expect = 2.637e-35
Identity = 65/76 (85.53%), Postives = 69/76 (90.79%), Query Frame = 2 
Query:  509 MEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQK 736
            M++N   RRKNATRETTS LKAWLNEHKKNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTW P  +
Sbjct:  221 MDLNGA-RRKNATRETTSTLKAWLNEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWEPRNR 295
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Fly
Match: ara (gene:FBgn0015904 transcript:FBtr0300551)

HSP 1 Score: 139.428 bits (350), Expect = 4.835e-35
Identity = 76/153 (49.67%), Postives = 93/153 (60.78%), Query Frame = 2 
Query:  392 PTMNPYFLESMD---HLQLLTNSQKSPMSSRVLHVPNHSENF-MEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKS-----------EDEADDLEDTDSSDIRSRLQDD 805
            P  NPY L+       +   T++   P +    + P  +  +    +   RRKNATRE+T+ LKAWLNEHKKNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTW P  ++           E + +DLE +  S     L  D
Sbjct:  200 PLSNPYGLKDTGAGPEMGAWTSAGLQPTTGYYSYDPMSAYGYGASYDLAARRKNATRESTATLKAWLNEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWEPKNRTDDDDDALVSDDEKDKEDLEPSKGSQGSVSLAKD 352
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Fly
Match: caup (gene:FBgn0015919 transcript:FBtr0075909)

HSP 1 Score: 139.428 bits (350), Expect = 5.520e-35
Identity = 62/71 (87.32%), Postives = 67/71 (94.37%), Query Frame = 2 
Query:  530 RRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSE 742
            RRKNATRE+T+ LKAWL+EHKKNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTW P  K+E
Sbjct:  229 RRKNATRESTATLKAWLSEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWEPKNKTE 299
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Zebrafish
Match: irx3b (iroquois homeobox 3b [Source:ZFIN;Acc:ZDB-GENE-030131-525])

HSP 1 Score: 149.058 bits (375), Expect = 3.155e-40
Identity = 87/173 (50.29%), Postives = 106/173 (61.27%), Query Frame = 2 
Query:  530 RRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSP------------------NQKSEDEADDLEDTDSSDIRSR----LQDDPASLTKNYSKELKNEFLSKLSAINNLSADISNPKIN---SNVTSKSTKPKIWSIADITS 973
            R KNATRE+TS LKAWL+EH+KNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTW P                   ++ EDE  DLE+ D+ DI  +     QDD  S  K    E  ++  ++   I +      +P      SN  S + KPKIWS+A+I +
Sbjct:  104 RPKNATRESTSTLKAWLSEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWVPKTRTDEDGNVYTSDNEDAEKRDEDEEIDLENIDTEDIEDKQDCDYQDDDKSTPKGSDSEEYDDARAEKRIIEDEEQIKKSPAEEQEPSNNISPALKPKIWSLAEIAT 276
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Zebrafish
Match: irx4b (iroquois homeobox 4b [Source:ZFIN;Acc:ZDB-GENE-040712-4])

HSP 1 Score: 147.902 bits (372), Expect = 5.524e-39
Identity = 88/194 (45.36%), Postives = 110/194 (56.70%), Query Frame = 2 
Query:  344 INQSINLYAPPGVAGCP--TMNPYFLESMDHLQLLTNSQKSPMSSRVLHVPNHSENFMEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDEA---DDLEDTDSSDIRSRLQDDP----ASLTKNYSKELKNEFLSKLSAINNLSADIS 898
            +  S + Y P   A  P   +N        H ++  +S   P    +         +  ++   RRKNATRETTS LKAWL EHKKNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTWSP  K+ DE    DD ED D +      Q++P         N+ K+  ++  S L   + + +D S
Sbjct:   78 VYDSCSTYGPDSAACYPLGKLNEKDGVQTGHSRVTQSSAYYPYDYPIGQYSYDRYGYGSVDVGTRRKNATRETTSTLKAWLQEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWSPRNKNSDEKECDDDQEDLDEA------QEEPIKTEQDFNDNHGKDDTDQLHSDLDDFDLVESDGS 265
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Zebrafish
Match: irx4b (iroquois homeobox 4b [Source:ZFIN;Acc:ZDB-GENE-040712-4])

HSP 1 Score: 147.902 bits (372), Expect = 5.524e-39
Identity = 88/194 (45.36%), Postives = 110/194 (56.70%), Query Frame = 2 
Query:  344 INQSINLYAPPGVAGCP--TMNPYFLESMDHLQLLTNSQKSPMSSRVLHVPNHSENFMEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDEA---DDLEDTDSSDIRSRLQDDP----ASLTKNYSKELKNEFLSKLSAINNLSADIS 898
            +  S + Y P   A  P   +N        H ++  +S   P    +         +  ++   RRKNATRETTS LKAWL EHKKNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTWSP  K+ DE    DD ED D +      Q++P         N+ K+  ++  S L   + + +D S
Sbjct:   78 VYDSCSTYGPDSAACYPLGKLNEKDGVQTGHSRVTQSSAYYPYDYPIGQYSYDRYGYGSVDVGTRRKNATRETTSTLKAWLQEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWSPRNKNSDEKECDDDQEDLDEA------QEEPIKTEQDFNDNHGKDDTDQLHSDLDDFDLVESDGS 265
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Zebrafish
Match: irx4b (iroquois homeobox 4b [Source:ZFIN;Acc:ZDB-GENE-040712-4])

HSP 1 Score: 147.902 bits (372), Expect = 5.524e-39
Identity = 88/194 (45.36%), Postives = 110/194 (56.70%), Query Frame = 2 
Query:  344 INQSINLYAPPGVAGCP--TMNPYFLESMDHLQLLTNSQKSPMSSRVLHVPNHSENFMEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDEA---DDLEDTDSSDIRSRLQDDP----ASLTKNYSKELKNEFLSKLSAINNLSADIS 898
            +  S + Y P   A  P   +N        H ++  +S   P    +         +  ++   RRKNATRETTS LKAWL EHKKNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTWSP  K+ DE    DD ED D +      Q++P         N+ K+  ++  S L   + + +D S
Sbjct:   78 VYDSCSTYGPDSAACYPLGKLNEKDGVQTGHSRVTQSSAYYPYDYPIGQYSYDRYGYGSVDVGTRRKNATRETTSTLKAWLQEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWSPRNKNSDEKECDDDQEDLDEA------QEEPIKTEQDFNDNHGKDDTDQLHSDLDDFDLVESDGS 265
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Zebrafish
Match: irx4b (iroquois homeobox 4b [Source:ZFIN;Acc:ZDB-GENE-040712-4])

HSP 1 Score: 147.902 bits (372), Expect = 5.524e-39
Identity = 88/194 (45.36%), Postives = 110/194 (56.70%), Query Frame = 2 
Query:  344 INQSINLYAPPGVAGCP--TMNPYFLESMDHLQLLTNSQKSPMSSRVLHVPNHSENFMEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDEA---DDLEDTDSSDIRSRLQDDP----ASLTKNYSKELKNEFLSKLSAINNLSADIS 898
            +  S + Y P   A  P   +N        H ++  +S   P    +         +  ++   RRKNATRETTS LKAWL EHKKNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTWSP  K+ DE    DD ED D +      Q++P         N+ K+  ++  S L   + + +D S
Sbjct:   78 VYDSCSTYGPDSAACYPLGKLNEKDGVQTGHSRVTQSSAYYPYDYPIGQYSYDRYGYGSVDVGTRRKNATRETTSTLKAWLQEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWSPRNKNSDEKECDDDQEDLDEA------QEEPIKTEQDFNDNHGKDDTDQLHSDLDDFDLVESDGS 265
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Xenopus
Match: lypla1 (lysophospholipase 1 [Source:Xenbase;Acc:XB-GENE-942736])

HSP 1 Score: 142.895 bits (359), Expect = 2.822e-37
Identity = 86/180 (47.78%), Postives = 109/180 (60.56%), Query Frame = 2 
Query:  509 MEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDEADDLEDTDSSDIRSRLQDDPASLTKNYSKELKNEFLSKLSAIN----NLSADISNPKINSN-----------------VTSKST-KPKIWSIADITSDNV 982
            ++++   RRKNATRE TS LK WL EH+KNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTWSP  K+ DE    +D    D  S  +D   S TK    ++ N + S+ S  N    + S D+   + N+                  VT  +T KP+IWS+A   + ++
Sbjct:  138 VDISCSSRRKNATRENTSTLKTWLYEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWSPKNKAMDEK---KDEKQEDYNSGCEDQ-GSGTK---PKVSNSYRSRSSECNLTPSDTSYDLYCNEANAEDYSGFEKNTLQENSDHLVTYGTTGKPRIWSLAHTAASSI 310
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Xenopus
Match: irx4 (iroquois homeobox 4 [Source:NCBI gene;Acc:100038068])

HSP 1 Score: 141.739 bits (356), Expect = 2.900e-36
Identity = 65/83 (78.31%), Postives = 70/83 (84.34%), Query Frame = 2 
Query:  500 ENFMEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDE 748
            + +  M+   RRKNATRETTS LKAWL EH+KNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTW P  K  DE
Sbjct:  134 DRYGTMDGSTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCSDE 216
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Xenopus
Match: ndufaf5 (NADH:ubiquinone oxidoreductase complex assembly factor 5 [Source:Xenbase;Acc:XB-GENE-975960])

HSP 1 Score: 139.043 bits (349), Expect = 1.263e-35
Identity = 71/111 (63.96%), Postives = 83/111 (74.77%), Query Frame = 2 
Query:  530 RRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDEAD-----------------DLEDTDSSDIRSRLQ-DDP 808
            R KNATRE+TS LKAWLNEH+KNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTW+P  ++++E +                 DLE+ D+ DI S+   DDP
Sbjct:  111 RPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPRSRTDEEGNAYGSDHEEDKHEDDEEIDLENIDTEDIESKEDLDDP 221
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Xenopus
Match: fancm (FA complementation group M [Source:Xenbase;Acc:XB-GENE-994655])

HSP 1 Score: 134.035 bits (336), Expect = 8.248e-34
Identity = 63/93 (67.74%), Postives = 74/93 (79.57%), Query Frame = 2 
Query:  464 MSSRVLHVPNHSENF-MEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKS 739
            M+  + + P  S  +  ++N    RKNATR+ T+ LKAWL EH+KNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTW+P  KS
Sbjct:   90 MTGALSYHPYGSAAYPYQLNDPAYRKNATRDATATLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPRNKS 182
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Xenopus
Match: slc9a5 (solute carrier family 9 member A5 [Source:Xenbase;Acc:XB-GENE-484916])

HSP 1 Score: 134.42 bits (337), Expect = 1.048e-33
Identity = 68/89 (76.40%), Postives = 75/89 (84.27%), Query Frame = 2 
Query:  533 RKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDEAD----DLEDTDSSDIR 787
            RKNATR+ T+ LKAWLNEH+KNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTW+P  +SEDE D    DLE  +  D R
Sbjct:  117 RKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWTPRNRSEDEEDDENIDLEKNEEDDPR 205
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Mouse
Match: Irx6 (Iroquois homeobox 6 [Source:MGI Symbol;Acc:MGI:1927642])

HSP 1 Score: 145.976 bits (367), Expect = 2.636e-38
Identity = 68/89 (76.40%), Postives = 78/89 (87.64%), Query Frame = 2 
Query:  509 MEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDE--ADDLEDT 769
            +E++S  RRKNATRE+TS LKAWL+EH+KNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTW+P  K  +E  AD  ED+
Sbjct:  139 VELSSAGRRKNATRESTSALKAWLHEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPKNKGGEERKADSGEDS 227
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Mouse
Match: Irx6 (Iroquois homeobox 6 [Source:MGI Symbol;Acc:MGI:1927642])

HSP 1 Score: 145.976 bits (367), Expect = 2.644e-38
Identity = 68/89 (76.40%), Postives = 78/89 (87.64%), Query Frame = 2 
Query:  509 MEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDE--ADDLEDT 769
            +E++S  RRKNATRE+TS LKAWL+EH+KNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTW+P  K  +E  AD  ED+
Sbjct:  139 VELSSAGRRKNATRESTSALKAWLHEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPKNKGGEERKADSGEDS 227
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Mouse
Match: Irx2 (Iroquois homeobox 2 [Source:MGI Symbol;Acc:MGI:1197526])

HSP 1 Score: 132.88 bits (333), Expect = 3.828e-37
Identity = 64/93 (68.82%), Postives = 75/93 (80.65%), Query Frame = 2 
Query:  464 MSSRVLHVPNHSENF-MEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKS 739
            M+  + + P  S  +  ++N    RKNATR+ T+ LKAWLNEH+KNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTW+P  KS
Sbjct:    1 MTGAISYHPYGSAAYPYQLNDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPRNKS 93
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Mouse
Match: Irx4 (Iroquois homeobox 4 [Source:MGI Symbol;Acc:MGI:1355275])

HSP 1 Score: 142.895 bits (359), Expect = 1.027e-36
Identity = 65/83 (78.31%), Postives = 71/83 (85.54%), Query Frame = 2 
Query:  500 ENFMEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDE 748
            + +  ++S  RRKNATRETTS LKAWL EH+KNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTW P  K  DE
Sbjct:  136 DRYGTVDSGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCADE 218
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Mouse
Match: Irx4 (Iroquois homeobox 4 [Source:MGI Symbol;Acc:MGI:1355275])

HSP 1 Score: 142.895 bits (359), Expect = 1.027e-36
Identity = 65/83 (78.31%), Postives = 71/83 (85.54%), Query Frame = 2 
Query:  500 ENFMEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDE 748
            + +  ++S  RRKNATRETTS LKAWL EH+KNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTW P  K  DE
Sbjct:  136 DRYGTVDSGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCADE 218
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. UniProt/SwissProt
Match: sp|P78412|IRX6_HUMAN (Iroquois-class homeodomain protein IRX-6 OS=Homo sapiens OX=9606 GN=IRX6 PE=1 SV=3)

HSP 1 Score: 147.902 bits (372), Expect = 4.251e-38
Identity = 95/218 (43.58%), Postives = 119/218 (54.59%), Query Frame = 2 
Query:  224 PLMCSFPSDTNLMQVSSTPSNASMFPMNGL----RSNLNHFNGLINQSINLYAPPGVAGCPTMNPYFLESMDHLQLLTNSQKSPMS----SRVLHVPNHSE-NFMEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDE---------------ADDLEDTDSSDIRS-RLQD 802
            P +C  P D+ L+  S+ P   +   + G      +    + G +  S     PP + G   +NP + E  +     T+S   P +     R L    +     +E++   RRKNATRETTS LKAWLNEH+KNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTW+P  K  +E               AD  E T S + R  RL D
Sbjct:   45 PALCCAPYDSRLLG-SARPELGAALGIYGAPYAAAAAAQSYPGYLPYSPE---PPSLYG--ALNPQY-EFKEAAGSFTSSLAQPGAYYPYERTLGQYQYERYGAVELSGAGRRKNATRETTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPKNKGGEERKAEGGEEDSLGCLTADTKEVTASQEARGLRLSD 255
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. UniProt/SwissProt
Match: sp|Q9ER75|IRX6_MOUSE (Iroquois-class homeodomain protein IRX-6 OS=Mus musculus OX=10090 GN=Irx6 PE=2 SV=2)

HSP 1 Score: 145.976 bits (367), Expect = 1.849e-37
Identity = 68/89 (76.40%), Postives = 78/89 (87.64%), Query Frame = 2 
Query:  509 MEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDE--ADDLEDT 769
            +E++S  RRKNATRE+TS LKAWL+EH+KNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTW+P  K  +E  AD  ED+
Sbjct:  139 VELSSAGRRKNATRESTSALKAWLHEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPKNKGGEERKADSGEDS 227
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. UniProt/SwissProt
Match: sp|P78413|IRX4_HUMAN (Iroquois-class homeodomain protein IRX-4 OS=Homo sapiens OX=9606 GN=IRX4 PE=1 SV=2)

HSP 1 Score: 144.821 bits (364), Expect = 1.709e-36
Identity = 66/83 (79.52%), Postives = 71/83 (85.54%), Query Frame = 2 
Query:  500 ENFMEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDE 748
            + +  M+S  RRKNATRETTS LKAWL EH+KNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTW P  K  DE
Sbjct:  135 DRYGTMDSGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCADE 217
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. UniProt/SwissProt
Match: sp|Q9QY61|IRX4_MOUSE (Iroquois-class homeodomain protein IRX-4 OS=Mus musculus OX=10090 GN=Irx4 PE=2 SV=1)

HSP 1 Score: 142.895 bits (359), Expect = 7.185e-36
Identity = 65/83 (78.31%), Postives = 71/83 (85.54%), Query Frame = 2 
Query:  500 ENFMEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDE 748
            + +  ++S  RRKNATRETTS LKAWL EH+KNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTW P  K  DE
Sbjct:  136 DRYGTVDSGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCADE 218
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. UniProt/SwissProt
Match: sp|Q9YGS0|IRX4_CHICK (Iroquois-class homeodomain protein IRX-4 OS=Gallus gallus OX=9031 GN=IRX4 PE=2 SV=1)

HSP 1 Score: 142.124 bits (357), Expect = 8.915e-36
Identity = 65/83 (78.31%), Postives = 70/83 (84.34%), Query Frame = 2 
Query:  500 ENFMEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDE 748
            + +  M+   RRKNATRETTS LKAWL EH+KNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTW P  K  DE
Sbjct:  134 DRYGAMDGGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCSDE 216
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. TrEMBL
Match: U3FCE7 (Iroquois protein 2 OS=Micrurus fulvius OX=8637 PE=2 SV=1)

HSP 1 Score: 155.606 bits (392), Expect = 4.012e-38
Identity = 73/111 (65.77%), Postives = 87/111 (78.38%), Query Frame = 2 
Query:  464 MSSRVLHVPNHSENF-MEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDEADDLEDTDSSDIRSR 793
            MS  + + P  S  +  ++N    RKNATR+ T+ LKAWL EH+KNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTW+P  KSEDE +DLE  +S  +RS+
Sbjct:   92 MSGAISYHPYGSPAYPYQLNDPAYRKNATRDATATLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPRNKSEDEDEDLEGGESGGMRSK 202
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. TrEMBL
Match: Q4S1Q0 (Chromosome 5 SCAF14766, whole genome shotgun sequence (Fragment) OS=Tetraodon nigroviridis OX=99883 GN=GSTENG00025448001 PE=4 SV=1)

HSP 1 Score: 144.05 bits (362), Expect = 7.914e-38
Identity = 69/85 (81.18%), Postives = 74/85 (87.06%), Query Frame = 2 
Query:  509 MEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSP-NQKSEDEADDL 760
            ++ NS  RRKNATRETTS LK WL EH+KNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTWSP N+  ED  DDL
Sbjct:   26 VDFNSTARRKNATRETTSTLKTWLYEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWSPKNKAGEDRKDDL 110
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. TrEMBL
Match: A1YGI2 (IRX6 (Fragment) OS=Pan paniscus OX=9597 GN=IRX6 PE=4 SV=1)

HSP 1 Score: 147.517 bits (371), Expect = 1.380e-37
Identity = 86/184 (46.74%), Postives = 109/184 (59.24%), Query Frame = 2 
Query:  224 PLMCSFPSDTNLMQVSSTPSNASMFPMNGL----RSNLNHFNGLINQSINLYAPPGVAGCPTMNPYFLESMDHLQLLTNSQKSPMS----SRVLHVPNHSE-NFMEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDE 748
            P +C  P D+ L+  S+ P   +   + G      +    + G +  S     PP + G   +NP + E  +     T+S   P +     R L    +     +E++   RRKNATRETTS LKAWLNEH+KNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTW+P  K  +E
Sbjct:   30 PALCCTPYDSRLLG-SARPELGATLGIYGAPYAAAAAAQSYPGYLPYSPE---PPSLYG--ALNPQY-EFKEAAGSFTSSLAQPGAYYPYERTLGQYQYERYGAVELSGAGRRKNATRETTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPKNKGGEE 206
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. TrEMBL
Match: A0A3B3DHN0 (Iroquois homeobox 4b OS=Oryzias melastigma OX=30732 PE=4 SV=1)

HSP 1 Score: 151.369 bits (381), Expect = 1.594e-37
Identity = 92/186 (49.46%), Postives = 114/186 (61.29%), Query Frame = 2 
Query:  530 RRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSP-------NQKSEDEAD----------------------DLED-----TDSSDIRSRLQDDPASLTKNYSKELKNEFLSKLSAINNLSADISNPKINSNVTSKSTKPKIWSIADITSDNVE 985
            RRKNATRETTS LKAWL EH+KNPYPTKGEKIMLA+IT+MTLTQVSTWFANARRRLKKENK+TWSP       ++  ED++D                      DLED     +D+SD   +LQ  P        ++   E  S+LSA+   S+      +N  + + +TKPKIWSIA  T+ +VE
Sbjct:  108 RRKNATRETTSTLKAWLQEHQKNPYPTKGEKIMLAIITRMTLTQVSTWFANARRRLKKENKVTWSPRACKSSDDRGCEDDSDEAERPLKSDNDLPDPPCADLQSDLEDFDLLESDASDGDGKLQFQPDVDINPPHRQPPKERPSELSAVEPRSSSF---YVNEELKNSTTKPKIWSIAH-TARSVE 289
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. TrEMBL
Match: A0A194Q503 (Iroquois-class homeodomain protein IRX-5 OS=Papilio xuthus OX=66420 GN=RR46_07208 PE=4 SV=1)

HSP 1 Score: 148.288 bits (373), Expect = 1.803e-37
Identity = 89/184 (48.37%), Postives = 105/184 (57.07%), Query Frame = 2 
Query:  509 MEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPN--------------QKSEDEADDLEDTDSSDIRSRLQDDPASLTKNYSKELKNEFLSKLSAINNLSADISNPKINS-----------NVTSKSTKPKIWSIADITSDNVE 985
            M++N   RRKNATRETTS LKAWLNEHKKNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTW P                KS D  D L+  DS    S   + P        +  ++E+    +     S +     I+              TS S KP+IWS+AD+ S + E
Sbjct:    1 MDLNGA-RRKNATRETTSTLKAWLNEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWEPRNRVDDDDNNNDDDDHKSNDGKDALDGKDSGTGSSEDGERPPQRLDLLGQRTESEWSESRADSGPESPEPYERPIHPAYQHLPSRAPPGSTSASAKPRIWSLADMASKDGE 183
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Cavefish
Match: irx4a (iroquois-class homeodomain protein irx-4 [Source:NCBI gene;Acc:103025323])

HSP 1 Score: 149.828 bits (377), Expect = 1.582e-39
Identity = 78/140 (55.71%), Postives = 96/140 (68.57%), Query Frame = 2 
Query:  500 ENFMEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDE---ADDLEDTDSSDIRSRLQDDPASLTKNYSKELKNEFLSKLSAINNLSADISNPKI 910
            + +  M+   RRKNATRETTS LKAWL EH+KNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTW P  K  DE    +D E +    I+S   DD     ++ S+E K+  LS L   + + ++ S  ++
Sbjct:  127 DRYGSMDGGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCSDEKRYGEDEEGSQEDQIKSETNDD-----ESRSREDKDLQLSDLDDFDAIESESSECEL 261
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Cavefish
Match: irx4b (iroquois-class homeodomain protein irx-4-B [Source:NCBI gene;Acc:103030452])

HSP 1 Score: 148.673 bits (374), Expect = 2.598e-39
Identity = 71/107 (66.36%), Postives = 82/107 (76.64%), Query Frame = 2 
Query:  503 NFMEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDE------ADDLEDTDSSDIRSRLQDD 805
             +  M+   RRKNATRETTS LKAWL EHK+NPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTWSP  K+ DE      +DD+E +    ++S  + D
Sbjct:  128 GYSSMDVSTRRKNATRETTSTLKAWLQEHKRNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWSPRNKASDEKGCDEDSDDVEGSQEETMKSEKESD 234
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Cavefish
Match: irx4b (iroquois-class homeodomain protein irx-4-B [Source:NCBI gene;Acc:103030452])

HSP 1 Score: 148.673 bits (374), Expect = 3.195e-39
Identity = 69/90 (76.67%), Postives = 75/90 (83.33%), Query Frame = 2 
Query:  503 NFMEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDEADDLEDTD 772
             +  M+   RRKNATRETTS LKAWL EHK+NPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTWSP  K+ DE    ED+D
Sbjct:  136 GYSSMDVSTRRKNATRETTSTLKAWLQEHKRNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWSPRNKASDEKGCDEDSD 225
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Cavefish
Match: irx3b (iroquois homeobox 3 [Source:NCBI gene;Acc:103035229])

HSP 1 Score: 134.806 bits (338), Expect = 5.392e-35
Identity = 61/91 (67.03%), Postives = 74/91 (81.32%), Query Frame = 2 
Query:  482 HVPNHSENFMEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDEAD 754
            H P       ++    R KNATRE+TS LKAWL+EH+KNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTW+P  +++++ +
Sbjct:   83 HAPFFPYGHYQLGDPSRPKNATRESTSTLKAWLSEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPKTRTDEDGN 173
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Cavefish
Match: irx1a (iroquois homeobox 1 [Source:NCBI gene;Acc:103024684])

HSP 1 Score: 132.494 bits (332), Expect = 1.329e-33
Identity = 63/81 (77.78%), Postives = 70/81 (86.42%), Query Frame = 2 
Query:  530 RRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDEADDLEDTD 772
            R KNATRE+TS LKAWLNEH+KNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENK+TW    K EDE  ++  +D
Sbjct:  115 RPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKVTWGARSK-EDEEGNIFGSD 194
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002620.1 (pep scaffold:Pmarinus_7.0:GL484724:8057:10194:-1 gene:ENSPMAG00000002391.1 transcript:ENSPMAT00000002620.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 126.716 bits (317), Expect = 6.590e-35
Identity = 57/69 (82.61%), Postives = 63/69 (91.30%), Query Frame = 2 
Query:  533 RKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKS 739
            RKNATR+ T+ LKAWLNEH+KNPYPTKGEKIMLA+IT+MTLTQVSTWFANARRRLKKENKMTW    +S
Sbjct:   41 RKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITRMTLTQVSTWFANARRRLKKENKMTWVTKARS 109
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Sea Lamprey
Match: mkxb (mohawk homeobox b [Source:ZFIN;Acc:ZDB-GENE-080513-2])

HSP 1 Score: 74.7146 bits (182), Expect = 2.049e-15
Identity = 34/67 (50.75%), Postives = 49/67 (73.13%), Query Frame = 2 
Query:  533 RKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLK---KENKMTWS 724
            ++ A ++    LK WL +H+ NPYPTK EKI+LA+ + MTL QVS WFANARRRLK   ++ +++W+
Sbjct:    5 KRQALQDMARPLKHWLYKHRHNPYPTKTEKILLALGSHMTLVQVSNWFANARRRLKNTVRQPELSWA 71
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Sea Lamprey
Match: pknox2 (pbx/knotted 1 homeobox 2 [Source:ZFIN;Acc:ZDB-GENE-031118-112])

HSP 1 Score: 56.6102 bits (135), Expect = 4.548e-9
Identity = 24/56 (42.86%), Postives = 38/56 (67.86%), Query Frame = 2 
Query:  530 RRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRL 697
            +R    +  T+++++WL +H  +PYPT+ EK  +A  T +TL QV+ WF NARRR+
Sbjct:  261 KRGVLPKHATTVMRSWLFQHIVHPYPTEDEKRQIANQTNLTLLQVNNWFINARRRI 316
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Sea Lamprey
Match: pknox2 (pbx/knotted 1 homeobox 2 [Source:ZFIN;Acc:ZDB-GENE-031118-112])

HSP 1 Score: 46.595 bits (109), Expect = 7.218e-6
Identity = 25/71 (35.21%), Postives = 37/71 (52.11%), Query Frame = 2 
Query:  476 VLHVPNHSENFMEMNSHPRRKNATR-----ETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTW 673
            V+ VPN         S  R+  + R       T I+++WL +H  +PYPT+ EK  +A  T +TL QV+ W
Sbjct:  232 VIQVPNTQAECDLSESDDRKMKSKRGVLPKHATGIMRSWLFQHIVHPYPTEDEKRQIAAQTNLTLLQVNNW 302
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Yeast
Match: TOS8 (Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication [Source:SGD;Acc:S000003064])

HSP 1 Score: 63.5438 bits (153), Expect = 1.099e-11
Identity = 30/58 (51.72%), Postives = 36/58 (62.07%), Query Frame = 2 
Query:  521 SHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRR 694
            +H +R N  + T SIL  WL+EH  NPYPT  EK  L   T +T  Q+S WF NARRR
Sbjct:  194 AHGKRSNLPKATVSILNKWLHEHVNNPYPTVQEKRELLAKTGLTKLQISNWFINARRR 251
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Yeast
Match: CUP9 (Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000006098])

HSP 1 Score: 59.3066 bits (142), Expect = 3.085e-10
Identity = 28/55 (50.91%), Postives = 33/55 (60.00%), Query Frame = 2 
Query:  530 RRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRR 694
            RR N  +ET  IL  WL  H  NPYPT+ EK  L + T +T  Q+S WF N RRR
Sbjct:  165 RRSNLPKETVQILNTWLLNHLNNPYPTQQEKRELLIKTGLTKIQLSNWFINVRRR 219
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Nematostella
Match: EDO41982 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S2T4])

HSP 1 Score: 129.798 bits (325), Expect = 6.187e-37
Identity = 61/69 (88.41%), Postives = 65/69 (94.20%), Query Frame = 2 
Query:  530 RRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQK 736
            RRKNATRETTS LKAWL EH+KNPYPTKGEKIMLA++TKMTLTQVSTWFANARRRLKKENKMTWSP  +
Sbjct:    2 RRKNATRETTSTLKAWLFEHRKNPYPTKGEKIMLAILTKMTLTQVSTWFANARRRLKKENKMTWSPRNR 70
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Nematostella
Match: EDO39375 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SAC9])

HSP 1 Score: 60.077 bits (144), Expect = 4.951e-10
Identity = 33/86 (38.37%), Postives = 47/86 (54.65%), Query Frame = 2 
Query:  440 LTNSQKSPMSSRVLHVPNHSENFMEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRL 697
            +   Q SPMS    + P  S          +R    ++ TSI+K WL +H  +PYPT+ EK  +A  T +T+ QV+ WF NARRR+
Sbjct:  179 VQQQQASPMS----YTPQQSATVKS-----KRGVLPKQATSIMKTWLFQHIMHPYPTEDEKRSIAQQTNLTILQVNNWFINARRRI 255
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Nematostella
Match: EDO41178 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S544])

HSP 1 Score: 55.0694 bits (131), Expect = 8.889e-10
Identity = 23/56 (41.07%), Postives = 37/56 (66.07%), Query Frame = 2 
Query:  530 RRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRL 697
            RR N  +++ ++L+ WL EH+ N YP++ EK  L+    +++ QV  WF NARRR+
Sbjct:   19 RRGNLPKDSVNVLRLWLWEHRFNAYPSEAEKQYLSKAANLSVLQVCNWFINARRRI 74
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Nematostella
Match: EDO36439 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SIN3])

HSP 1 Score: 57.3806 bits (137), Expect = 3.555e-9
Identity = 26/59 (44.07%), Postives = 39/59 (66.10%), Query Frame = 2 
Query:  521 SHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRL 697
            S  +R    +  T+I+KAWL +H  +PYP++ +K  LA  T +T+ QV+ WF NARRR+
Sbjct:  238 SQKKRGIFPKAATNIMKAWLFQHLTHPYPSEEQKRSLAQETGLTILQVNNWFINARRRI 296
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Nematostella
Match: EDO43361 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RYQ8])

HSP 1 Score: 50.0618 bits (118), Expect = 1.036e-6
Identity = 22/63 (34.92%), Postives = 37/63 (58.73%), Query Frame = 2 
Query:  515 MNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKK 703
            +++  +R+N +++ T IL  +   H  NPYP++  K  LA    +++ Q+S WF N R R KK
Sbjct:  196 LDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELARKCNISVAQISNWFGNKRIRYKK 258
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Medaka
Match: irx4b (iroquois-class homeodomain protein irx-4-like [Source:NCBI gene;Acc:101157469])

HSP 1 Score: 149.828 bits (377), Expect = 3.963e-40
Identity = 104/263 (39.54%), Postives = 132/263 (50.19%), Query Frame = 2 
Query:  326 NHFNGLINQSINLYA----------PPGVAGCPTMNPYFLESMDHLQLLTNSQKSPMSSRVLHVPNHSENFMEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSP-------NQKSEDEAD----------------------DLED-----TDSSDIRSRLQDDPASLTKNYSKELKN-------EFLSKLSAINNLSADISNPKINSNVTSKSTKPKIWSIA 961
            N++N     +  +YA          P G    PT  PY  E M                   H P        ++S  RRKNATRETTS LKAWL EH+KNPYPTKGEKIMLA+IT+MTLTQVSTWFANARRRLKKENK+TWSP       ++  ED++D                      DLED     +D+SD  ++LQ  P    +N +  L +       E LS     + +    S+  +N  + S ++KPKIWSIA
Sbjct:   56 NYYNTCSGDASTVYARGPIDPKEAAPVGTTQTPTYYPY--EYM-----------------FGHHPCERYGHSCLDSSSRRKNATRETTSTLKAWLQEHQKNPYPTKGEKIMLAIITRMTLTQVSTWFANARRRLKKENKVTWSPRACKSSDDRGYEDDSDEAERPLKRDEDLPDQPCADLQSDLEDFDLLESDASDGDAKLQFQPDVDKRNPNTNLPHKQLVPLKERLSDCPEFSTVKHRSSSFYVNEELESTTSKPKIWSIA 299
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Medaka
Match: irx6a (iroquois homeobox 6 [Source:NCBI gene;Acc:101173209])

HSP 1 Score: 147.517 bits (371), Expect = 1.274e-38
Identity = 69/89 (77.53%), Postives = 76/89 (85.39%), Query Frame = 2 
Query:  509 MEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSP-NQKSEDEADDLEDTD 772
            ++ N   RRKNATRETTS LK WL EH+KNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTWSP N+ S+D  DDL  +D
Sbjct:  134 VDFNGTARRKNATRETTSTLKTWLYEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWSPKNKTSDDRKDDLSKSD 222
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Medaka
Match: irx6a (iroquois homeobox 6 [Source:NCBI gene;Acc:101173209])

HSP 1 Score: 147.132 bits (370), Expect = 1.299e-38
Identity = 69/89 (77.53%), Postives = 76/89 (85.39%), Query Frame = 2 
Query:  509 MEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSP-NQKSEDEADDLEDTD 772
            ++ N   RRKNATRETTS LK WL EH+KNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTWSP N+ S+D  DDL  +D
Sbjct:  120 VDFNGTARRKNATRETTSTLKTWLYEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWSPKNKTSDDRKDDLSKSD 208
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Medaka
Match: irx4a (iroquois-class homeodomain protein irx-4-like [Source:NCBI gene;Acc:101159378])

HSP 1 Score: 144.436 bits (363), Expect = 1.133e-37
Identity = 70/105 (66.67%), Postives = 79/105 (75.24%), Query Frame = 2 
Query:  500 ENFMEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDEA---DDLEDTDSSDIRSRLQDD 805
            + +  M+   RRKNATRETTS LKAWL EH+KNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTW P  K  +E    DD + +    I+S   DD
Sbjct:  134 DRYGSMDGGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWPPRNKGSEEKRYDDDEDGSQEEQIKSENNDD 238
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Medaka
Match: irx3a (iroquois homeobox 3 [Source:NCBI gene;Acc:101162111])

HSP 1 Score: 134.806 bits (338), Expect = 1.517e-34
Identity = 60/75 (80.00%), Postives = 70/75 (93.33%), Query Frame = 2 
Query:  530 RRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDEAD 754
            R KNATRE+TS LKAWL+EH+KNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTW+P  ++++E +
Sbjct:  110 RPKNATRESTSTLKAWLSEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPRNRTDEEGN 184
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Planmine SMEST
Match: SMESG000026100.1 (SMESG000026100.1)

HSP 1 Score: 712.605 bits (1838), Expect = 0.000e+0
Identity = 381/381 (100.00%), Postives = 381/381 (100.00%), Query Frame = 2 
Query:   98 MSTDQLIKDXXXXXXXXXXXXXXXLLRDGNLHFSEEQLKRNFPLMCSFPSDTNLMQVSSTPSNASMFPMNGLRSNLNHFNGLINQSINLYAPPGVAGCPTMNPYFLESMDHLQLLTNSQKSPMSSRVLHVPNHSENFMEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDEADDLEDTDSSDIRSRLQDDPASLTKNYSKELKNEFLSKLSAINNLSADISNPKINSNVTSKSTKPKIWSIADITSDNVEFXXXXXXXXXXXXXNEKDCQIYSSDPLKNITTQNPAVQFLLWKHKEIYQNPIPSLFMKSPRLPFDFNHLKNRLSLDTNQLNGISK 1240
            MSTDQLIKDSISFNMSMNNSKFSSLLRDGNLHFSEEQLKRNFPLMCSFPSDTNLMQVSSTPSNASMFPMNGLRSNLNHFNGLINQSINLYAPPGVAGCPTMNPYFLESMDHLQLLTNSQKSPMSSRVLHVPNHSENFMEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDEADDLEDTDSSDIRSRLQDDPASLTKNYSKELKNEFLSKLSAINNLSADISNPKINSNVTSKSTKPKIWSIADITSDNVEFSQDKSSSNSLASSNEKDCQIYSSDPLKNITTQNPAVQFLLWKHKEIYQNPIPSLFMKSPRLPFDFNHLKNRLSLDTNQLNGISK
Sbjct:    1 MSTDQLIKDSISFNMSMNNSKFSSLLRDGNLHFSEEQLKRNFPLMCSFPSDTNLMQVSSTPSNASMFPMNGLRSNLNHFNGLINQSINLYAPPGVAGCPTMNPYFLESMDHLQLLTNSQKSPMSSRVLHVPNHSENFMEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDEADDLEDTDSSDIRSRLQDDPASLTKNYSKELKNEFLSKLSAINNLSADISNPKINSNVTSKSTKPKIWSIADITSDNVEFSQDKSSSNSLASSNEKDCQIYSSDPLKNITTQNPAVQFLLWKHKEIYQNPIPSLFMKSPRLPFDFNHLKNRLSLDTNQLNGISK 381
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Planmine SMEST
Match: SMESG000026100.1 (SMESG000026100.1)

HSP 1 Score: 705.286 bits (1819), Expect = 0.000e+0
Identity = 357/357 (100.00%), Postives = 357/357 (100.00%), Query Frame = 2 
Query:  170 LLRDGNLHFSEEQLKRNFPLMCSFPSDTNLMQVSSTPSNASMFPMNGLRSNLNHFNGLINQSINLYAPPGVAGCPTMNPYFLESMDHLQLLTNSQKSPMSSRVLHVPNHSENFMEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDEADDLEDTDSSDIRSRLQDDPASLTKNYSKELKNEFLSKLSAINNLSADISNPKINSNVTSKSTKPKIWSIADITSDNVEFXXXXXXXXXXXXXNEKDCQIYSSDPLKNITTQNPAVQFLLWKHKEIYQNPIPSLFMKSPRLPFDFNHLKNRLSLDTNQLNGISK 1240
            LLRDGNLHFSEEQLKRNFPLMCSFPSDTNLMQVSSTPSNASMFPMNGLRSNLNHFNGLINQSINLYAPPGVAGCPTMNPYFLESMDHLQLLTNSQKSPMSSRVLHVPNHSENFMEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDEADDLEDTDSSDIRSRLQDDPASLTKNYSKELKNEFLSKLSAINNLSADISNPKINSNVTSKSTKPKIWSIADITSDNVEFSQDKSSSNSLASSNEKDCQIYSSDPLKNITTQNPAVQFLLWKHKEIYQNPIPSLFMKSPRLPFDFNHLKNRLSLDTNQLNGISK
Sbjct:   11 LLRDGNLHFSEEQLKRNFPLMCSFPSDTNLMQVSSTPSNASMFPMNGLRSNLNHFNGLINQSINLYAPPGVAGCPTMNPYFLESMDHLQLLTNSQKSPMSSRVLHVPNHSENFMEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDEADDLEDTDSSDIRSRLQDDPASLTKNYSKELKNEFLSKLSAINNLSADISNPKINSNVTSKSTKPKIWSIADITSDNVEFSQDKSSSNSLASSNEKDCQIYSSDPLKNITTQNPAVQFLLWKHKEIYQNPIPSLFMKSPRLPFDFNHLKNRLSLDTNQLNGISK 367
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Planmine SMEST
Match: SMESG000061184.1 (SMESG000061184.1)

HSP 1 Score: 145.591 bits (366), Expect = 9.229e-39
Identity = 83/157 (52.87%), Postives = 103/157 (65.61%), Query Frame = 2 
Query:  509 MEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDEADDLEDTDS----SDIRSRLQDDPA--SLTKNYSKELKNEFLSKLSAINNLSADISNPKINSNVTSKSTKPKIWSIA 961
            +++NS  RRKNATRE+TS LKAWL EH KNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTWSP  +S+D  +  ++TD+    +D    L+ D    +L+      +K+ F SKL+ +                     KPKIWS+A
Sbjct:  167 LDLNS-ARRKNATRESTSTLKAWLQEHIKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWSPKNRSDDATNSDQETDTKCKETDSDDGLKTDCQLDTLSDQDDLAMKSSFPSKLNDV---------------------KPKIWSLA 301
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Planmine SMEST
Match: SMESG000015279.1 (SMESG000015279.1)

HSP 1 Score: 141.354 bits (355), Expect = 7.357e-37
Identity = 94/157 (59.87%), Postives = 110/157 (70.06%), Query Frame = 2 
Query:  527 PRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDEADDLEDTDSSDIRSRLQDDPASLTKNYSK---ELK---NEFLSKLSAINNLSADISNPKINSNVTSKSTKPKIWSIADITSDN 979
            PRRKNATRETTSILKAWLN+HKKNPYPTKGEKIMLA+ITKMTLTQVSTWFANARRRLKKENKMTW+   + ED+ D+  D D  D      ++   ++K+ S+   EL+     FLSK S  ++ SAD          TSKS   KIWSIA+I  DN
Sbjct:  161 PRRKNATRETTSILKAWLNQHKKNPYPTKGEKIMLALITKMTLTQVSTWFANARRRLKKENKMTWTARTRHEDDIDETGDDDEDDDDEEDNENDDDISKSDSRFESELRKNDESFLSK-SEKSDTSAD---------ETSKSN--KIWSIAEIADDN 305
[Close]
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Planmine SMEST
Match: SMESG000022899.1 (SMESG000022899.1)

HSP 1 Score: 124.79 bits (312), Expect = 6.813e-33
Identity = 65/118 (55.08%), Postives = 85/118 (72.03%), Query Frame = 2 
Query:  461 PMSSRVLHVPNHSENFMEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDEADDLEDTDSSDIRSRLQDDPAS 814
            P++   LH  NH++    +N    +KNATRE +S LKAWL EHK NPYP+KGEKI+LA++T+M+LTQVSTWFANARRRLKKENK+ W  N KS D  D   D++ S++ +R  + P S
Sbjct:   75 PITLAHLHTINHAD----VNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKS-DNPDSTSDSELSELFTREYEKPNS 187
The following BLAST results are available for this feature:
BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
IRX68.852e-3943.58iroquois homeobox 6 [Source:HGNC Symbol;Acc:HGNC:1... [more]
IRX43.558e-3779.52iroquois homeobox 4 [Source:HGNC Symbol;Acc:HGNC:6... [more]
IRX43.558e-3779.52iroquois homeobox 4 [Source:HGNC Symbol;Acc:HGNC:6... [more]
IRX43.558e-3779.52iroquois homeobox 4 [Source:HGNC Symbol;Acc:HGNC:6... [more]
IRX46.264e-3781.48iroquois homeobox 4 [Source:HGNC Symbol;Acc:HGNC:6... [more]
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BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
irx-12.926e-3147.83Putative iroquois-class homeodomain protein irx-1 ... [more]
ceh-603.939e-940.68C. Elegans Homeobox [Source:UniProtKB/TrEMBL;Acc:... [more]
ceh-203.951e-736.51Homeobox protein ceh-20 [Source:UniProtKB/Swiss-P... [more]
unc-621.127e-629.06Homeobox protein unc-62 [Source:UniProtKB/Swiss-P... [more]
unc-621.127e-629.06Homeobox protein unc-62 [Source:UniProtKB/Swiss-P... [more]
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BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
mirr2.086e-3585.53gene:FBgn0014343 transcript:FBtr0075911[more]
mirr2.086e-3585.53gene:FBgn0014343 transcript:FBtr0075912[more]
mirr2.637e-3585.53gene:FBgn0014343 transcript:FBtr0330077[more]
ara4.835e-3549.67gene:FBgn0015904 transcript:FBtr0300551[more]
caup5.520e-3587.32gene:FBgn0015919 transcript:FBtr0075909[more]
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BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
irx3b3.155e-4050.29iroquois homeobox 3b [Source:ZFIN;Acc:ZDB-GENE-030... [more]
irx4b5.524e-3945.36iroquois homeobox 4b [Source:ZFIN;Acc:ZDB-GENE-040... [more]
irx4b5.524e-3945.36iroquois homeobox 4b [Source:ZFIN;Acc:ZDB-GENE-040... [more]
irx4b5.524e-3945.36iroquois homeobox 4b [Source:ZFIN;Acc:ZDB-GENE-040... [more]
irx4b5.524e-3945.36iroquois homeobox 4b [Source:ZFIN;Acc:ZDB-GENE-040... [more]
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BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
lypla12.822e-3747.78lysophospholipase 1 [Source:Xenbase;Acc:XB-GENE-94... [more]
irx42.900e-3678.31iroquois homeobox 4 [Source:NCBI gene;Acc:10003806... [more]
ndufaf51.263e-3563.96NADH:ubiquinone oxidoreductase complex assembly fa... [more]
fancm8.248e-3467.74FA complementation group M [Source:Xenbase;Acc:XB-... [more]
slc9a51.048e-3376.40solute carrier family 9 member A5 [Source:Xenbase;... [more]
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BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Irx62.636e-3876.40Iroquois homeobox 6 [Source:MGI Symbol;Acc:MGI:192... [more]
Irx62.644e-3876.40Iroquois homeobox 6 [Source:MGI Symbol;Acc:MGI:192... [more]
Irx23.828e-3768.82Iroquois homeobox 2 [Source:MGI Symbol;Acc:MGI:119... [more]
Irx41.027e-3678.31Iroquois homeobox 4 [Source:MGI Symbol;Acc:MGI:135... [more]
Irx41.027e-3678.31Iroquois homeobox 4 [Source:MGI Symbol;Acc:MGI:135... [more]
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BLAST of Iroquois-class homeodomain protein IRX-4 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P78412|IRX6_HUMAN4.251e-3843.58Iroquois-class homeodomain protein IRX-6 OS=Homo s... [more]
sp|Q9ER75|IRX6_MOUSE1.849e-3776.40Iroquois-class homeodomain protein IRX-6 OS=Mus mu... [more]
sp|P78413|IRX4_HUMAN1.709e-3679.52Iroquois-class homeodomain protein IRX-4 OS=Homo s... [more]
sp|Q9QY61|IRX4_MOUSE7.185e-3678.31Iroquois-class homeodomain protein IRX-4 OS=Mus mu... [more]
sp|Q9YGS0|IRX4_CHICK8.915e-3678.31Iroquois-class homeodomain protein IRX-4 OS=Gallus... [more]
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BLAST of Iroquois-class homeodomain protein IRX-4 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
U3FCE74.012e-3865.77Iroquois protein 2 OS=Micrurus fulvius OX=8637 PE=... [more]
Q4S1Q07.914e-3881.18Chromosome 5 SCAF14766, whole genome shotgun seque... [more]
A1YGI21.380e-3746.74IRX6 (Fragment) OS=Pan paniscus OX=9597 GN=IRX6 PE... [more]
A0A3B3DHN01.594e-3749.46Iroquois homeobox 4b OS=Oryzias melastigma OX=3073... [more]
A0A194Q5031.803e-3748.37Iroquois-class homeodomain protein IRX-5 OS=Papili... [more]
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BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
irx4a1.582e-3955.71iroquois-class homeodomain protein irx-4 [Source:N... [more]
irx4b2.598e-3966.36iroquois-class homeodomain protein irx-4-B [Source... [more]
irx4b3.195e-3976.67iroquois-class homeodomain protein irx-4-B [Source... [more]
irx3b5.392e-3567.03iroquois homeobox 3 [Source:NCBI gene;Acc:10303522... [more]
irx1a1.329e-3377.78iroquois homeobox 1 [Source:NCBI gene;Acc:10302468... [more]
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BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 4
Match NameE-valueIdentityDescription
ENSPMAT00000002620.16.590e-3582.61pep scaffold:Pmarinus_7.0:GL484724:8057:10194:-1 g... [more]
mkxb2.049e-1550.75mohawk homeobox b [Source:ZFIN;Acc:ZDB-GENE-080513... [more]
pknox24.548e-942.86pbx/knotted 1 homeobox 2 [Source:ZFIN;Acc:ZDB-GENE... [more]
pknox27.218e-635.21pbx/knotted 1 homeobox 2 [Source:ZFIN;Acc:ZDB-GENE... [more]
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BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 2
Match NameE-valueIdentityDescription
TOS81.099e-1151.72Homeodomain-containing protein and putative transc... [more]
CUP93.085e-1050.91Homeodomain-containing transcriptional repressor; ... [more]
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BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO419826.187e-3788.41Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO393754.951e-1038.37Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO411788.889e-1041.07Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO364393.555e-944.07Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO433611.036e-634.92Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Iroquois-class homeodomain protein IRX-4 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
irx4b3.963e-4039.54iroquois-class homeodomain protein irx-4-like [Sou... [more]
irx6a1.274e-3877.53iroquois homeobox 6 [Source:NCBI gene;Acc:10117320... [more]
irx6a1.299e-3877.53iroquois homeobox 6 [Source:NCBI gene;Acc:10117320... [more]
irx4a1.133e-3766.67iroquois-class homeodomain protein irx-4-like [Sou... [more]
irx3a1.517e-3480.00iroquois homeobox 3 [Source:NCBI gene;Acc:10116211... [more]
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BLAST of Iroquois-class homeodomain protein IRX-4 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000026100.10.000e+0100.00SMESG000026100.1[more]
SMESG000026100.10.000e+0100.00SMESG000026100.1[more]
SMESG000061184.19.229e-3952.87SMESG000061184.1[more]
SMESG000015279.17.357e-3759.87SMESG000015279.1[more]
SMESG000022899.16.813e-3355.08SMESG000022899.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30030504 ID=SMED30030504|Name=Iroquois-class homeodomain protein IRX-4|organism=Schmidtea mediterranea sexual|type=transcript|length=1469bp
GATTGATGCGACATTTTCAAGCAAACGAGCCAATCAAATCATTTGAAATC
TGACCAATGAAAATAAATACCAAATTAACGAATTTCAATTAATAAAAATG
TCAACTGACCAATTAATAAAAGATTCTATTTCCTTTAACATGTCAATGAA
TAATTCAAAATTCTCCTCATTGTTGCGAGATGGAAATTTGCATTTTTCGG
AAGAACAACTGAAACGAAATTTCCCATTGATGTGTTCATTTCCTTCTGAT
ACGAATTTGATGCAGGTTTCGTCAACTCCGTCTAATGCGTCGATGTTTCC
TATGAATGGGCTTCGGTCGAATTTGAATCACTTTAATGGGTTAATTAATC
AATCTATTAATCTTTATGCTCCTCCTGGAGTCGCCGGATGTCCAACAATG
AATCCATATTTTTTAGAATCAATGGACCATTTACAACTATTAACAAATTC
CCAAAAATCTCCCATGAGTTCGAGAGTTCTTCATGTTCCCAATCATTCAG
AAAATTTCATGGAAATGAATTCTCACCCTAGAAGAAAAAATGCAACTCGA
GAAACGACTAGTATTTTAAAGGCGTGGCTAAATGAACACAAAAAAAATCC
ATATCCGACAAAAGGAGAAAAGATAATGTTAGCAGTCATTACAAAAATGA
CCCTGACCCAAGTTAGTACTTGGTTTGCTAATGCTCGTAGACGACTAAAA
AAGGAAAACAAAATGACTTGGTCTCCAAATCAGAAGTCTGAAGATGAAGC
CGATGATTTAGAAGACACTGATTCTTCGGATATCCGATCGAGATTGCAAG
ATGATCCAGCATCTCTTACGAAAAACTATTCCAAAGAATTGAAAAATGAA
TTTCTATCCAAATTGTCTGCTATAAACAATCTCTCAGCCGACATATCAAA
TCCAAAAATCAACTCAAATGTCACTTCAAAATCGACAAAACCGAAAATCT
GGTCAATTGCTGACATTACTTCCGATAATGTTGAATTCAGTCAAGATAAA
TCCTCCTCAAATTCTCTCGCATCCTCTAACGAAAAAGACTGTCAGATTTA
TTCTTCAGATCCGTTGAAAAATATCACAACGCAAAATCCCGCTGTCCAAT
TCCTGTTGTGGAAACACAAAGAGATCTATCAAAATCCCATTCCCAGTCTA
TTCATGAAATCTCCGAGGTTGCCATTCGATTTCAATCATTTAAAAAATCG
ACTTTCCCTCGATACAAATCAATTAAATGGAATATCGAAATAATTGGAAT
GGCAGAATTTGTAGACTAACTGCAGAAAGCACTTATTTCACATCTATGAT
ACCTCAGGTTTATTGAAGAAACACAAACATATTTGACAGTTCTTTGTACA
TTTATCCCAGTCTTCAATTTTGGTCTGTAAAAATGTGGCAGTTTTCTCTA
AATTTTGAACGATTTTCTATTTTCATTGAAAATGATTCTTCATCGGTATT
GACATCATTTTATAAATAA
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protein sequence of SMED30030504-orf-1

>SMED30030504-orf-1 ID=SMED30030504-orf-1|Name=SMED30030504-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=382bp
MSTDQLIKDSISFNMSMNNSKFSSLLRDGNLHFSEEQLKRNFPLMCSFPS
DTNLMQVSSTPSNASMFPMNGLRSNLNHFNGLINQSINLYAPPGVAGCPT
MNPYFLESMDHLQLLTNSQKSPMSSRVLHVPNHSENFMEMNSHPRRKNAT
RETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRL
KKENKMTWSPNQKSEDEADDLEDTDSSDIRSRLQDDPASLTKNYSKELKN
EFLSKLSAINNLSADISNPKINSNVTSKSTKPKIWSIADITSDNVEFSQD
KSSSNSLASSNEKDCQIYSSDPLKNITTQNPAVQFLLWKHKEIYQNPIPS
LFMKSPRLPFDFNHLKNRLSLDTNQLNGISK*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000136whole organism
PLANA:0000418head
PLANA:0000420parapharyngeal region
Vocabulary: INTERPRO
TermDefinition
IPR003893Iroquois_homeo
IPR001356Homeobox_dom
IPR008422Homeobox_KN_domain
IPR009057Homeobox-like_sf
IPR017970Homeobox_CS
IPR011528NERD
Vocabulary: molecular function
TermDefinition
GO:0003677DNA binding
GO:0043565sequence-specific DNA binding
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
GO:0005737cytoplasm
Vocabulary: biological process
TermDefinition
GO:0006355regulation of transcription, DNA-templated
GO:0006351transcription, DNA-templated
GO:0007275multicellular organism development
GO:0007399nervous system development
GO:0007420brain development
GO:0008406gonad development
GO:0009953dorsal/ventral pattern formation
GO:0009954proximal/distal pattern formation
GO:0030154cell differentiation
GO:0048701embryonic cranial skeleton morphogenesis
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR003893Iroquois-class homeodomain proteinSMARTSM00548irx_3coord: 277..294
e-value: 0.0031
score: 26.7
IPR001356Homeobox domainSMARTSM00389HOX_1coord: 142..207
e-value: 9.4E-13
score: 58.4
IPR001356Homeobox domainPROSITEPS50071HOMEOBOX_2coord: 140..203
score: 13.2
IPR001356Homeobox domainCDDcd00086homeodomaincoord: 145..204
e-value: 2.07662E-12
score: 59.5645
IPR008422Homeobox KN domainPFAMPF05920Homeobox_KNcoord: 160..199
e-value: 3.4E-15
score: 55.7
NoneNo IPR availableGENE3DG3DSA:1.10.10.60coord: 141..203
e-value: 6.5E-26
score: 91.9
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 204..238
NoneNo IPR availablePANTHERPTHR11211IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRXcoord: 84..316
IPR017970Homeobox, conserved sitePROSITEPS00027HOMEOBOX_1coord: 178..201
IPR009057Homeobox-like domain superfamilySUPERFAMILYSSF46689Homeodomain-likecoord: 144..210